WorldWideScience
 
 
1

Rheology and BIA  

Science.gov (United States)

Is it possible to link erythrosedimentation to a global monofrequency of 50KHz bio impedance analysis parameters? Two populations, Control (N=20, average age of 38 ± 18 years, 55% female predominance) versus neopathology undergoing chemotherapy treatment (N=10, average age of 51 ± 10 years, 70% female predominance) were exposed to two simple tests: Blood composition and erythrosedimentation and global Bio Impedance mono frequency (50 KHz) assessment analysis. The Results of simple statistical tests (average, anova) show that the two populations were significantly different (1%), using both biological bood tests or BIA. Only the neopathological group showed a significant correlation between the erythrosedimentation the bio impedance parameters such as Phase angle or Xc (ratio - 0.93 and - 0.93)

Piquemal, M.; Zanotti, J. C.

2012-12-01

2

Rheology and BIA  

International Nuclear Information System (INIS)

Is it possible to link erythrosedimentation to a global monofrequency of 50KHz bio impedance analysis parameters? Two populations, Control (N=20, average age of 38 ± 18 years, 55% female predominance) versus neopathology undergoing chemotherapy treatment (N=10, average age of 51 ± 10 years, 70% female predominance) were exposed to two simple tests: Blood composition and erythrosedimentation and global Bio Impedance mono frequency (50 KHz) assessment analysis. The Results of simple statistical tests (average, anova) show that the two populations were significantly different (1%), using both biological bood tests or BIA. Only the neopathological group showed a significant correlation between the erythrosedimentation the bio impedance parameters such as Phase angle or Xc (ratio ? 0.93 and ? 0.93)

2012-12-20

3

BIA National Geospatial Resource Center  

Science.gov (United States)

The National Geospatial Resource Center (NGRC) provides GIS training to BIA offices and employees of Federally Recognized Tribal Entities. There is no tuition cost for this training. Expenses for transportation, hotel accommodations, and meals are the responsibility of the participant. Training courses are available at the National Indian Programs Training Center (NIPTC) in Albuquerque, New Mexico and various field locations. Training dates and availability are subject to change at the discretion of NGRC.

2011-02-28

4

On the Balmer discontinuity of BIa supergiants  

International Nuclear Information System (INIS)

We show that the disagreement between the observed Balmer discontinuities of BIa supergiants and those predicted by the classical models of stellar atmospheres, is a function of the effective temperature. Some attempts at explaining to this disagreement are briefly discussed. There exists an abridged english version in the french text.

1987-01-01

5

On the Balmer discontinuity of BIa supergiants  

Energy Technology Data Exchange (ETDEWEB)

We show that the disagreement between the observed Balmer discontinuities of BIa supergiants and those predicted by the classical models of stellar atmospheres, is a function of the effective temperature. Some attempts at explaining to this disagreement are briefly discussed. There exists an abridged english version in the french text.

Zorec, J.; Mercado-Ibanez, R.

1987-11-21

6

Dinitro and mononitrobenzo(ghi)perylenes and mononitrocoronene are highly mutagenic in the Ames Salmonella assay  

Energy Technology Data Exchange (ETDEWEB)

Benzo(ghi)perylene (B(ghi)Per, (191-24-2)) and coronene (Cor, (191-07-1)) are major constituents of the polycyclic aromatic hydrocarbons (PAH) found in automobile exhaust and polluted air. Nitration of these PAH by NO/sub 2/ and traces of HNO/sub 3/, which are also formed in automobile exhaust, seems highly probable. To identify the presence of these nitroarenes in environmental samples and to examine their mutagenic potencies the authors synthesized and characterized nitro derivatives of both PAH. 5-NO/sub 2/B(ghi)Per(81316-87-2) and 1-NO/sub 2/Cor(81316-84-9) produced 405 and 340 reverants/nmole, respectively, in TA98 in the presence of 0.6 mg of microsomal enzymes (S-9) per plate in the Ames test. 5,8-diNO/sub 2/B(ghi)Per (83292-25-5) and 5,10-diNO/sub 2/B(ghi)Per (83292-26-6) produced 21,500 and 4000 revertants/nmole in TA98NR without microsomal activation. Mutagenicity for the dinitrobenzo(ghi)perylenes was also high in TA98NR and TA97 but was reduced by 97% in TA98-1,8DNP. There is close similarity in the orientation and distances between reactive sites (nitronium ion and carbocation) on the dinitrobenzo(ghi)perylenes and 1,6 dinitropyrene (42397-64-8) and 1,8-dinitropyrene (42397-65-9).

Vance, W.A.; Chan, R.

1983-01-01

7

Genotoxicity-Related Chemistry of Human Metabolites of Benzo[ghi]perylene (B[ghi]P) Investigated using Electro-Optical Arrays and DNA/Microsome Biocolloid Reactors with LC-MS/MS.  

UK PubMed Central (United Kingdom)

There is limited and sometimes contradictory information about the genotoxicity of the polycyclic aromatic hydrocarbon benzo[ghi]perylene (B[ghi]P). Using recently developed metabolic toxicity screening arrays and a biocolloid reactor-LC-MS/MS approach, both featuring films of DNA and human metabolic enzymes, we demonstrated the relatively low reactivity of metabolically activated B[ghi]P toward DNA. Electro-optical toxicity screening arrays showed that B[ghi]P metabolites damage DNA at a 3-fold lower rate than benzo[a]pyrene (B[a]P), whose metabolites have a strong and well-understood propensity for DNA damage. Metabolic studies using magnetic bead biocolloid reactors coated with microsomal enzymes in 96-well plates showed that cyt P450s 1A1 and 1B1 provide high activity for B[ghi]P and B[a]P conversion. Consistent with published results, the major metabolism of B[ghi]P involved oxidations at 3,4 and 11,12 positions, leading to the formation of B[ghi]P 3,4-oxide and B[ghi]P 3,4,11,12-bisoxide. B[ghi]P 3,4-oxide was synthesized and reacted with deoxyadenosine at N6 and N7 positions and with deoxyguanosine at the N2 position. B[ghi]P 3,4-oxide is hydrolytically unstable and transforms into the 3,4-diol or converts to 3- or 4-hydroxy B[ghi]P. LC-MS/MS of reaction products from the magnetic biocolloid reactor particles coated with DNA and human enzymes revealed for the first time that a major DNA adduct results from the reaction between B[ghi]P 3,4,11,12-bisoxide and deoxyguanosine. Results also demonstrated 5-fold lower formation rates of the major DNA adduct for B[ghi]P metabolites compared to B[a]P. Overall, results from both the electro-optical array and biocolloid reactor-LC-MS/MS consistently suggest a lower human genotoxicity profile of B[ghi]P than B[a]P.

Pan S; Li D; Zhao L; Schenkman JB; Rusling JF

2013-08-01

8

Resistivity and phase in localized BIA  

Science.gov (United States)

We describe a system for highly reproducible non-invasive rf impedance measurements as a function of position along body segments such as the thigh. Results are reported for mainly healthy male and female subjects ranging in age from 19 to 65 and in body-mass index from 15 to 40. A principal conclusion is that the phase of the impedance falls monotonically with increasing distance from the knee, with average values substantially above what is found using standard, whole-body bioelectrical impedance analysis (BIA). To compensate for thigh shape, the data are further analysed using an anatomical model based on reasonable approximations for the distributions of muscle, fat and bone, yielding values of the effective resistivity for current flow parallel to the muscle fibres. The phase and resistivity results are discussed with reference to the whole-body BIA study of maintenance haemodialysis patients by Chertow et al, and in regard to possible physiological correlations observed in this work.

Shiffman, C. A.; Aaron, R.; Amoss, V.; Therrien, J.; Coomler, K.

1999-10-01

9

76 FR 4369 - Interim Deputation Agreements; Interim BIA Adult Detention Facility Guidelines  

Science.gov (United States)

...Interim Deputation Agreements; Interim BIA Adult Detention Facility Guidelines AGENCY...announces the online publication of the Interim BIA Adult Detention Facility Guidelines and...Affairs Web site. DATES: These Interim BIA Adult Detention Facility Guidelines...

2011-01-25

10

BIA-MS-MS: biomolecular interaction analysis for functional proteomics.  

UK PubMed Central (United Kingdom)

One of the experimental processes of functional proteomics is the analysis of protein interaction. Here, we review a new analytical platform, BIA-MS, for protein interaction analysis. BIA-MS is an integration of a surface plasmon resonance biosensor for real-time interaction analysis and mass spectrometry for the subsequent identification of interacting molecules.

Natsume T; Nakayama H; Isobe T

2001-10-01

11

DOCKING OF STRUCTURALLY RELATED DIOLEPOXIDES OF BENZO(GHI)FLUORANTHENE WITH DNA  

Science.gov (United States)

Docking of structurally-related diolepoxides of benzo{ghi}fluoranthene and benzo{c}phenanthrene with DNA Polycyclic aromatic hydrocarbons are a class of chemicals found in the environment. Some class members are potent carcinogens while others with similar structures show litt...

12

Use of electrocardiogram (ECG) electrodes for Bioelectrical Impedance Analysis (BIA)  

Science.gov (United States)

BIA is a safe, noninvasive, portable and relatively inexpensive method of estimating body composition that is practical and suitable for individual use and large-scale studies. However, the cost of the electrodes recommended by some BIA manufacturers is too high for developing countries; where very often the long and complicated process of importation reduces the time they can be used. The purpose of this study was to evaluate the use of two types of ECG electrodes (2290 and 2228 by 3M®) in BIA measurements to decrease the costs of the test. The results showed that the 2228 ECG electrodes can be used in BIA measurements for adult's body composition assessment. These electrodes are available in the domestic market and their costs are 92% lower than the electrodes recommended by manufacturer. The results show a new cost-benefit relation for BIA method and make this a more accessible tool for individual tests, large-scale researches and studies in the community.

Caicedo-Eraso, J. C.; González-Correa, C. H.; González-Correa, C. A.

2012-12-01

13

Characterisation of a functional intronic polymorphism in the human growth hormone (GHI) gene  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract The +1169A allele of the A/T single nucleotide polymorphism (SNP; rs2665802), located within intron 4 of the human growth hormone I (GHI) gene, has been associated with reduced levels of circulating GH and insulin-like growth factor I, a reduced risk of colorectal cancer and a predisposition to osteoporosis. Whether this intronic SNP is itself the functional polymorphism responsible for exerting a direct effect on GHI gene expression, however, or whether it is instead in linkage disequilibrium with the functional SNP, has been an open question. The evolutionary conservation of the +1169T allele (and the surrounding intronic sequence) in the bovine genome, as well as in primate genomes, is, however, suggestive of its functionality. Although a potential alternative splice site spans the location of the +1169 SNP, polymerase chain reaction-based assays failed to yield any evidence for alternative splicing associated with either allele. To determine whether the +1169 SNP, in different allelic combinations with SNPs at -278 (G/T), -57 (T/G) and +2103 (C/T), exerts a direct effect on gene expression and/or GH secretion, we performed a series of transfections of various GHI haplotype-expressing constructs into rat GC (somatotroph) cells. The results obtained provided evidence to support the contention that the +1169A allele contributes directly to the observed reduction in both GHI gene expression and GH secretion. Part of the apparent influence of the +1169A-bearing allele on GHI gene expression and GH secretion may still, however, be attributable to alleles of additional SNPs in cis to +1169A and located within either the promoter or the 3'-flanking region.

Millar David S; Horan Martin; Chuzhanova Nadia A; Cooper David N

2010-01-01

14

Wielokierunkowa bro? wirusa HBV – bia?ko X  

Directory of Open Access Journals (Sweden)

Full Text Available W materiale genetycznym wirusa HBV, oprócz bia?ek strukturalnych oraz polimerazy DNA, zakodowane jest równie? niestrukturalne bia?ko X (HBx). Jest to bia?ko wielofunkcyjne, które sprzyja rozwojowi przewlek?ego wirusowego zapalenia w?troby typu B poprzez podtrzymywanie replikacji i ekspresji genów wirusa oraz modyfikowanie mechanizmów komórkowych, tworz?c ?rodowisko korzystne dla przetrwania wirusa. Z?o?ony wp?yw HBx na przemiany komórki w?trobowej obejmuje: modulacj? ekspresji genów i transkrypcji komórkowej, zmiany transdukcji sygna?ów wewn?trzkomórkowych, modyfikacj? cyklu komórkowego, wp?yw na czynno?? mitochondriów, degradacj? bia?ek i procesy apoptozy, aktywacj? komórek gwia?dzistych. HBx odgrywa tak?e rol? w patogenezie pierwotnego raka w?troby, przyczyniaj?c si? do transformacji nowotworowej hepatocytów. (Gastroenterol. Pol., 2010, Vol. 17, No. 5, p. 371-373)

Joanna Koz?owska; Joanna Jab?o?ska; Alicja Wierci?ska-Drapa?o

2010-01-01

15

25 CFR 171.110 - How does BIA administer its irrigation facilities?  

Science.gov (United States)

... false How does BIA administer its irrigation facilities? 171.110 Section 171...DEPARTMENT OF THE INTERIOR LAND AND WATER IRRIGATION OPERATION AND MAINTENANCE General...110 How does BIA administer its irrigation facilities? (a) We administer...

2009-04-01

16

25 CFR 166.901 - How will the BIA select an agriculture intern?  

Science.gov (United States)

... false How will the BIA select an agriculture intern? 166.901 Section 166... LAND AND WATER GRAZING PERMITS Agriculture Education, Education Assistance...166.901 How will the BIA select an agriculture intern? (a) The purpose...

2009-04-01

17

25 CFR 162.210 - When can BIA grant a permit covering agricultural land?  

Science.gov (United States)

...can BIA grant a permit covering agricultural land? 162.210 Section 162...can BIA grant a permit covering agricultural land? (a) We may grant a permit covering agricultural land in the same manner as we...

2010-04-01

18

Use of electrocardiogram (ECG) electrodes for Bioelectrical Impedance Analysis (BIA)  

International Nuclear Information System (INIS)

[en] BIA is a safe, noninvasive, portable and relatively inexpensive method of estimating body composition that is practical and suitable for individual use and large-scale studies. However, the cost of the electrodes recommended by some BIA manufacturers is too high for developing countries; where very often the long and complicated process of importation reduces the time they can be used. The purpose of this study was to evaluate the use of two types of ECG electrodes (2290 and 2228 by 3M®) in BIA measurements to decrease the costs of the test. The results showed that the 2228 ECG electrodes can be used in BIA measurements for adult's body composition assessment. These electrodes are available in the domestic market and their costs are 92% lower than the electrodes recommended by manufacturer. The results show a new cost-benefit relation for BIA method and make this a more accessible tool for individual tests, large-scale researches and studies in the community.

2012-12-20

19

Die Bedeutung der bioelektrischen Impedanzanalyse (BIA) im geriatrischen Bereich  

Directory of Open Access Journals (Sweden)

Full Text Available Die bioelektrische Impedanzanalyse (BIA) wird seit ca. 20 Jahren als schnelle und nichtinvasive Methode zur Bestimmung der Körperzusammensetzung eingesetzt. Nach Anlegen von je zwei Meßelektroden an Hand und Fuß des Probanden werden im hochfrequenten Wechselstromfeld (meist 50 kHz) bei konstanter Stromstärke die Widerstände Resistanz (Rz, Ohmscher Widerstand) und Reaktanz (Xc, kapazitiver Widerstand) gemessen. Die physikalischen Grundlagen zur Auswertung der Meßergebnisse sind seit langem bekannt und folgen dem Ohmschen Gesetz. Der menschliche Körper wird modellhaft als System elektrischer Leiter betrachtet, wobei parallel und seriell verknüpfte Gewebe die Leiterbahnen darstellen. Für die Auswertung ist entscheidend, daß verschiedene Gewebe- und Zellarten den Strom unterschiedlich gut leiten. Das Skelett und die Fettmasse leiten den Strom so schlecht, daß sie bei der Widerstandsmessung mittels BIA nicht erfaßt werden. Das Muskelgewebe und die Extrazellulärräume leiten den Strom wesentlich besser und machen den Hauptanteil der Widerstandsmessung mit BIA aus.

Edlinger E

2002-01-01

20

Bioaccumulation of cyclopenta[cd]pyrene and benzo[ghi]fluoranthene by mussels transplanted in a coastal lagoon.  

Science.gov (United States)

The bioaccumulation of two isomeric non-alternant non-priority polycyclic aromatic hydrocarbons (PAHs), namely cyclopenta[cd]pyrene and benzo[ghi]fluoranthene, was investigated in caged mussels (Mytilus galloprovincialis) exposed for 30 days in three sites of a coastal lagoon (Pialassa Baiona, Ravenna, Italy) contaminated by pyrogenic PAHs. The concentration of cyclopenta[cd]pyrene and benzo[ghi]fluoranthene increased from undetectable levels in reference mussels withdrawn from the Adriatic sea to 10-30 ng g(-1) dry weight in transplanted mussels. Other contaminants bioaccumulated by caged mussels included pyrene, fluoranthene and mercury. Whilst the isomer concentration ratio pyrene/fluoranthene in biota was comparable to that observed in sediments, the cyclopenta[cd]pyrene/benzo[ghi]fluoranthene ratio was much lower in mussels than in sediments. The lower sediment biota accumulation factor of cyclopenta[cd]pyrene with respect to that of benzo[ghi]fluoranthene was tentatively attributed to the greater biological activity of the former compound, which contains a reactive olefinic bond in the cyclopenta fused ring moiety. Given the higher mutagenic activity of cyclopenta[cd]pyrene with respect to other priority PAHs, its bioaccumulation from contaminated sediments may rise considerably the overall toxicity of PAH residues in exposed biota. PMID:16423379

Fabbri, Daniele; Baravelli, Valentina; Giannotti, Katia; Donnini, Filippo; Fabbri, Elena

2006-01-19

 
 
 
 
21

Bioaccumulation of cyclopenta[cd]pyrene and benzo[ghi]fluoranthene by mussels transplanted in a coastal lagoon.  

UK PubMed Central (United Kingdom)

The bioaccumulation of two isomeric non-alternant non-priority polycyclic aromatic hydrocarbons (PAHs), namely cyclopenta[cd]pyrene and benzo[ghi]fluoranthene, was investigated in caged mussels (Mytilus galloprovincialis) exposed for 30 days in three sites of a coastal lagoon (Pialassa Baiona, Ravenna, Italy) contaminated by pyrogenic PAHs. The concentration of cyclopenta[cd]pyrene and benzo[ghi]fluoranthene increased from undetectable levels in reference mussels withdrawn from the Adriatic sea to 10-30 ng g(-1) dry weight in transplanted mussels. Other contaminants bioaccumulated by caged mussels included pyrene, fluoranthene and mercury. Whilst the isomer concentration ratio pyrene/fluoranthene in biota was comparable to that observed in sediments, the cyclopenta[cd]pyrene/benzo[ghi]fluoranthene ratio was much lower in mussels than in sediments. The lower sediment biota accumulation factor of cyclopenta[cd]pyrene with respect to that of benzo[ghi]fluoranthene was tentatively attributed to the greater biological activity of the former compound, which contains a reactive olefinic bond in the cyclopenta fused ring moiety. Given the higher mutagenic activity of cyclopenta[cd]pyrene with respect to other priority PAHs, its bioaccumulation from contaminated sediments may rise considerably the overall toxicity of PAH residues in exposed biota.

Fabbri D; Baravelli V; Giannotti K; Donnini F; Fabbri E

2006-08-01

22

The hemes of Escherichia coli nitrate reductase A (NarGHI): potentiometric effects of inhibitor binding to narI.  

Science.gov (United States)

We have potentiometrically characterized the two hemes of Escherichia coli nitrate reductase A (NarGHI) using EPR and optical spectroscopy. NarGHI contains two hemes, a low-potential heme b(L) (E(m,7) = 20 mV; g(z)() = 3.36) and a high-potential heme b(H) (E(m, 7) = 120 mV; g(z)() = 3.76). Potentiometric analyses of the g(z)() features of the heme EPR spectra indicate that the E(m,7) values of both hemes are sensitive to the menaquinol analogue 2-n-heptyl-4-hydroxyquinoline N-oxide (HOQNO). This inhibitor causes a potential-inversion of the two hemes (for heme b(L), E(m,7) = 120 mV; for heme b(H), E(m,7) = 60 mV). This effect is corroborated by optical spectroscopy of a heme b(H)-deficient mutant (NarGHI(H56R)) in which the heme b(L) undergoes a DeltaE(m,7) of 70 mV in the presence of HOQNO. Another potent inhibitor of NarGHI, stigmatellin, elicits a moderate heme b(L) DeltaE(m,7) of 30 mV, but has no detectable effect on heme b(H). No effect is elicited by either inhibitor on the line shape or the E(m,7) values of the [3Fe-4S] cluster coordinated by NarH. When NarI is expressed in the absence of NarGH [NarI(DeltaGH)], two hemes are detected in potentiometric titrations with E(m,7) values of 37 mV (heme b(L); g(z)() = 3.15) and -178 mV (heme b(H); g(z)() = 2.92), suggesting that heme b(H) may be exposed to the aqueous milieu in the absence of NarGH. The identity of these hemes was confirmed by recording EPR spectra of NarI(DeltaGH)(H56R). HOQNO binding titrations followed by fluorescence spectroscopy suggest that in both NarGHI and NarI(DeltaGH), this inhibitor binds to a single high-affinity site with a K(d) of approximately 0.2 microM. These data support a functional model for NarGHI in which a single dissociable quinol binding site is associated with heme b(L) and is located toward the periplasmic side of NarI. PMID:10504245

Rothery, R A; Blasco, F; Magalon, A; Asso, M; Weiner, J H

1999-09-28

23

[Abdomen specific bioelectrical impedance analysis (BIA) methods for evaluation of abdominal fat distribution].  

UK PubMed Central (United Kingdom)

Two novel bioelectrical impedance analysis (BIA) methods have been developed recently for evaluation of intra-abdominal fat accumulation. Both methods use electrodes that are placed on abdominal wall and allow evaluation of intra-abdominal fat area (IAFA) easily without radiation exposure. Of these, "abdominal BIA" method measures impedance distribution along abdominal anterior-posterior axis, and IAFA by BIA method(BIA-IAFA) is calculated from waist circumference and the voltage occurring at the flank. Dual BIA method measures impedance of trunk and body surface at the abdominal level and calculates BIA-IAFA from transverse and antero-posterior diameters of the abdomen and the impedance of trunk and abdominal surface. BIA-IAFA by these two BIA methods correlated well with IAFA measured by abdominal CT (CT-IAFA) with correlatipn coefficient of 0.88 (n = 91, p < 0.0001) for the former, and 0.861 (n = 469, p < 0.01) for the latter. These new BIA methods are useful for evaluating abdominal adiposity in clinical study and routine clinical practice of metabolic syndrome and obesity.

Ida M; Hirata M; Hosoda K; Nakao K

2013-02-01

24

Zmiany skórne jako objaw prodromalny nawrotu przewlek?ej bia?aczki szpikowej - opis przypadku  

Directory of Open Access Journals (Sweden)

Full Text Available Zmiany skórne mog? by? jednym ze znamiennych objawów nowotworów uk?adu krwiotwórczego. Wykwity skórne mog? poprzedza? wyst?pienie bia?aczki, pojawi? si? w czasie przebiegu choroby lub by? jednym z objawów prodromalnych jej nawrotu. Zmiany skórne w przebiegu bia?aczek s? specyficzne (leu-kemia cutis, leukemic vasculitis) lub niespecyficzne (leukemidy). Bia?aczka przebiegaj?ca z wykwitami w obr?bie skóry (leukemia cutis) oraz bia?aczkowe zapalenie naczy? (leukemic vasculitis) wyst?puj? rzadko, ale ?wiadcz? o du?ej z?o?liwo?ci choroby. Niespecyficzne wykwity skórne w przebiegu bia?aczek mog? sprawia? du?e trudno?ci diagnostyczne, ze wzgl?du na du?? ró?norodno??. Wielopostaciowe, niespecyficzne zmiany skórne, cz?sto przebiegaj?ce ze ?wi?dem, szczególnie u osób starszych, nale?y zawsze ró?nicowa? z bia?aczk?. Praca przedstawia przypadek pacjenta z przewlek?? bia?aczk? mielobla-styczn? (chronic myeloblastic leukemia, CML) w wywiadzie, przyj?tego na oddzia? dermatologiczny z podejrzeniem polekowego zapalenia skóry. Obserwowane u chorego niespecyficzne zmiany skórne okaza?y si? znamiennym objawem prodromalnym nawrotu przewlek?ej bia?aczki mieloblastycznej.

Anna Rosi?ska; Zygmunt Adamski

2008-01-01

25

Bioelectrical impedance analysis (BIA) equations validation against hydrodensitometry in a Colombian population  

Science.gov (United States)

Several studies have shown that the accuracy of BIA results depends of ethnicity, age, gender, hormonal and genetic variations and, so far, there are not specific equations for Colombian population. The purpose was to evaluate reported BIA equations to determine their usefulness in body composition assessment in young females from Colombia using hydrodensitometry as the reference method. A sample of 30 young females was evaluated. Inclusion and exclusion criteria were defined to minimize the variability of BIA. Height, weight, multi-frequency BIA, residual lung volume (RV) and underwater weight (UWW) were measured. Five BIA equations met the inclusion criteria of this study. Three equations overestimated and two equations underestimated body fat (BF). Paired Student t-test and Bland and Altman analysis (pBIA equations. However, all standard error of estimate (SEE) to BF was greater than 2.7 kg. This study showed that the five selected BIA equations are not valid for estimation of body composition in young females from Colombia. It is recommended to develop BIA equations to improve BF fat assessment in our population.

Caicedo-Eraso, J. C.; Gonzalez-Correa, C. A.; Gonzalez-Correa, C. H.

2013-04-01

26

Carotenoids in certain lichens of Bia?owie?a Forest  

Directory of Open Access Journals (Sweden)

Full Text Available Column-, and thin-layer chromatography revealed the presence of the following carotenoids in the thalli of 29 lichen species from Bia?owie?a Forest: ?-carotene, ?-carotene, ?-cryptoxanthin, ?-cryptoxanthin, lutein, 3'-epilutein, zeaxanthin, ?-carotene monoepoxide, lutein epoxide, antheraxanthin, 3'-hydroxyechinenone, ?-doradexanthin, canthaxanthin, astaxanthin, neoxani thin, violaxanthin and mutatoxanthin. The total content of carotenoids ranged from 16.83 (Cladonia rangiferina) to 92.98 µg g dry wt (Xanthoria parietina). There were differences in carotenoid composition, concentration of each carotenoid, and in the total content in the thalli of four species collected from niches with different insolation.

Bazyli Czeczuga

1994-01-01

27

What makes a BIA equation unique? Validity of eight-electrode multifrequency BIA to estimate body composition in a healthy adult population.  

UK PubMed Central (United Kingdom)

BACKGROUND/OBJECTIVES: The validity of bioelectrical impedance analysis (BIA) for body composition analysis is limited by assumptions relating to body shape. Improvement in BIA technology could overcome these limitations and reduce the population specificity of the BIA algorithm. SUBJECTS/METHODS: BIA equations for the prediction of fat-free mass (FFM), total body water (TBW) and extracellular water (ECW) were generated from data obtained on 124 Caucasians (body mass index 18.5-35 kg/m(2)) using a four-compartment model and dilution techniques as references. The algorithms were validated in an independent multiethnic population (n=130). The validity of BIA results was compared (i) between ethnic groups and (ii) with results from the four-compartment model and two-compartment methods (air-displacement plethysmography, dual-energy X-ray absorptiometry and deuterium dilution). RESULTS: Indices were developed from segmental R and Xc values to represent the relative contribution of trunk and limbs to total body conductivity. The coefficient of determination for all prediction equations was high (R(2): 0.94 for ECW, 0.98 for FFM and 0.98 for TBW) and root mean square error was low (1.9 kg for FFM, 0.8 l for ECW and 1.3 kg for TBW). The bias between BIA results and different reference methods was not statistically different between Afro-American, Hispanic, Asian or Caucasian populations and showed a similar difference (-0.2-0.2 kg FFM) when compared with the bias between different two-compartment reference methods (-0.2-0.3 kg FFM). CONCLUSIONS: An eight-electrode, segmental multifrequency BIA is a valid tool to estimate body composition in healthy euvolemic adults compared with the validity and precision of other two-compartment reference methods. Population specificity is of minor importance when compared with discrepancies between different reference methods.

Bosy-Westphal A; Schautz B; Later W; Kehayias JJ; Gallagher D; Müller MJ

2013-01-01

28

Body composition changes by DXA, BIA and skinfolds during exercise training in women.  

UK PubMed Central (United Kingdom)

PURPOSE: Few studies have examined responsiveness of bioimpedance (BIA) to detect changes over time in body composition using a longitudinal design. Accuracy of BIA and skinfold thickness in estimating body composition among 39-64 year-old women was investigated using dual-energy X-ray absorptiometry (DXA) as a criterion method both cross-sectionally and during a training intervention. METHODS: 97 women had percentage of fat assessed using DXA, skinfolds and eight-polar BIA using multi-frequency current. Fat mass and lean mass were estimated by DXA and BIA. Measurements were performed before and after the 21-week training intervention. RESULTS: At baseline relative to DXA, BIA under predicted percentage of fat (-6.50 %) and fat mass (-3.42 kg) and overestimated lean mass (3.18 kg) considerably. Also skinfold measurement under predicted percentage of fat compared to DXA, but the difference was smaller (-1.69 % units). Skinfold measurement overestimated percentage of fat at low values and underestimated at high values (r (2) = 0.535). A significant bias was detected between DXA and BIA's estimate of change in percentage of fat, fat mass and lean mass. Compared to DXA, BIA and skinfolds underestimated the training-induced positive changes in body composition. CONCLUSIONS: BIA and skinfold methods compared to DXA are not interchangeable to quantify the percentage of fat, fat mass and lean mass at the cross-sectional design in middle-aged women. Moreover, exercise training-induced small changes in body composition cannot be detected with BIA or skinfold method, even though DXA was able to measure statistically significant within-group changes in body composition after training.

Sillanpää E; Häkkinen A; Häkkinen K

2013-09-01

29

Czynniki determinuj?ce i modyfikuj?ce warto?? od?ywcz? bia?ka  

Directory of Open Access Journals (Sweden)

Full Text Available W pracy, która jest obszernym streszczeniem referatu wyg?oszonego na Sympozjum „Znaczenie bia?ka w?y-wieniu niemowl?t i ma?ych dzieci", omówiono wp?yw sk?adu aminokwasowego oraz niektórych procesów technologicznych i kulinarnych na jako?? bia?ka po?ywienia. Wskazano na mo?liwo?? oceny jako?ci bia?ka na podstawie wska?ników okre?lonych po jego analizie chemicznej (AAS, EAAI) lub w badaniach na szczurach (PER, NPU).

Edward Jab?o?ski

2000-01-01

30

25 CFR 171.400 - Who is responsible for structures on a BIA irrigation project?  

Science.gov (United States)

...Who is responsible for structures on a BIA irrigation project? 171.400 Section 171.400...DEPARTMENT OF THE INTERIOR LAND AND WATER IRRIGATION OPERATION AND MAINTENANCE Irrigation Facilities § 171.400 Who is...

2009-04-01

31

Bia?ka szoku termicznego w reumatoidalnym zapaleniu stawów: przyjaciel czy wróg?  

Directory of Open Access Journals (Sweden)

Full Text Available Reumatoidalne zapalenie stawów (RZS) jest jedn? z najcz??ciej wyst?puj?cych chorób reumatycznych na ?wiecie. RZS to uci??liwa, progresywna oraz wci?? nieuleczalna uk?adowa choroba tkanki ??cznej o pod?o?u autoimmunizacyjnym. Liczne doniesienia wskazuj?, i? silnie zachowane w ewolucji bia?ka szoku termicznego (HSP) oddzia?uj? z uk?adem immunologicznym. Ostatnie prace badawcze dowodz?, ?e bia?ka HSP pe?ni? istotn? rol? w regulacji chronicznej reakcji zapalnej w RZS, przy czym najwi?cej informacji dotyczy roli bia?ek opieku?czych nale??cych do klasy HSP70, HSP60 i HSP40. Praca omawia doniesienia naukowe z ostatnich lat dotycz?ce roli bia?ek HSP w rozwoju chorób reumatycznych oraz potencjalne mo?liwo?ci zastosowania HSP w immunoterapii pacjentów cierpi?cych na RZS.

Stefan Tukaj; Barbara Lipi?ska

2011-01-01

32

25 CFR 171.310 - Can I use water delivered by BIA for livestock purposes?  

Science.gov (United States)

...MAINTENANCE Water Use § 171.310 Can I use water delivered by BIA for livestock purposes? Yes...jeopardize our facilities; (c) Adversely affect the water rights or water supply; or (d) Cause additional costs to us that...

2013-04-01

33

Rola wybranych bia?ek reguluj?cych proces apoptozy w raku trzustki  

Directory of Open Access Journals (Sweden)

Full Text Available Badania ostatnich lat wskazuj? na istotn? rol? wieloetapowej sekwencji mutacji protoonkogenów i genów supresorowych, w tym tak?e genów reguluj?cych apoptoz? w karcynogenezie trzustki. Apoptoza – programowana ?mier? komórki – jest z?o?onym procesem regulowanym przez wiele czynników zewn?trz- i wewn?trzkomórkowych. Przyczyn? zaburze? apoptozy w komórkach nowotworowych s? mutacje genów supresorowych reguluj?cych apoptoz? (p53, BRCA-1), genów koduj?cych bia?ka nale??ce do rodziny bcl-2 oraz genów koduj?cych kaspazy. Spo?ród bia?ek nale??cych do rodziny Bcl-2 najwa?niejszymi bia?kami proapoptycznymi s? Bax, Bcl-xS, Bak, Bad, Bid, za? bia?kami antyapoptycznymi Bcl-2, Bcl-xL oraz Bcl-w. W komórkach nowotworowych, niepohamowany wzrost komórek jest – mi?dzy innymi – uwarunkowany wzrostem ich oporno?ci na czynniki indukuj?ce apoptoz?. Jest to jedn? z przyczyn niepowodze? terapeutycznych w leczeniu nowotworów. W raku trzustki (RT) najlepiej udokumentowana jest wysoka cz?sto?? wyst?powania mutacji genu p53 i genów rodziny bcl-2. Prognostyczna rola bia?ek kodowanych przez te geny pozostaje niejasna, a publikowane doniesienia sprzeczne. Prawdopodobnie rokowniczo korzystna jest wzmo?ona ekspresja bia?ka Bax, w przeciwie?stwie do ekspresji bia?ka Bcl-xL, które zwi?zane jest z krótszym czasem prze?ycia chorych na raka trzustki. Mo?liwo?ci ewentualnego wykorzystania klinicznego obserwowanych zaburze? w terapii chorób nowotworowych wymagaj? dalszych bada?.

Renata Talar-Wojnarowska; Ewa Ma?ecka-Panas

2004-01-01

34

Transient kinetic studies of heme reduction in Escherichia coli nitrate reductase A (NarGHI) by menaquinol.  

Science.gov (United States)

We have studied the transient kinetics of quinol-dependent heme reduction in Escherichia coli nitrate reductase A (NarGHI) by the menaquinol analogue menadiol using the stopped-flow method. Four kinetic phases are observed in the reduction of the hemes. A transient species, likely to be associated with a semiquinone radical anion, is observed with kinetics that correlates with one of the phases. The decay of the transient species and the formation of the second reduction phase of the hemes can be fitted to a double-exponential equation giving similar rate constants, k(1) = 9.24 +/- 0.9 s(-1) and k(2) = 0.22 +/- 0.02 s(-1) for the decay of the transient species, and k(1) = 9.23 +/- 0.9 s(-1) and k(2) = 0.22 +/- 0.02 s(-1) for the formation of the reduction phase. The quinol-binding-site inhibitors 2-n-heptyl-4-hydroxyquinoline-N-oxide (HOQNO) and stigmatellin have significant and different inhibitory effects on the reduction kinetics. The kinetics of heme reduction in NarI expressed in the absence of the NarGH catalytic dimer (NarI(DeltaGH) exhibits only two kinetic phases, and the decay of the transient species also correlates kinetically with the second reduction phase of the hemes. We have also studied nitrate-dependent heme reoxidation following quinol-dependent heme reduction using a sequential stopped-flow method. HOQNO elicits a much stronger inhibitory effect than stigmatellin on the reoxidation of the hemes. On the basis of our results, we propose schemes for the mechanism of NarGHI reduction by menaquinol and reoxidation by nitrate. PMID:12731882

Zhao, Zhongwei; Rothery, Richard A; Weiner, Joel H

2003-05-13

35

Bioelectrical impedance analysis (BIA): a proposal for standardization of the classical method in adults  

International Nuclear Information System (INIS)

The accuracy of BIA measurements is limited by different sources of error such as physical model, cross sectional area, ethnicity, body hydration, age and level of body fat among other variables. Equation for each population is required as they can produce overestimation when manufacturer's equations are used. The classical measurements hand to foot has shown better correlation against hydrodensitometry than foot to foot or hand to hand. However there is a lack for an accepted standard of BIA procedures. This is compounded when there is not a good report of the BIA study's methodology; hence the comparability between the results is poor and reduces the reliability of the method. Perhaps, standardization of methods would be the first step for BIA studies to move forward and subsequently improve its accuracy. Standardized procedures could also minimize the impact of these variables on studies results. The aim of this study was to propose a protocol as a checklist to standardize BIA procedures and produce comparable results from future studies performed with the classic hand-foot configuration in adults.

2012-12-20

36

Bioelectrical impedance analysis (BIA): a proposal for standardization of the classical method in adults  

Science.gov (United States)

The accuracy of BIA measurements is limited by different sources of error such as physical model, cross sectional area, ethnicity, body hydration, age and level of body fat among other variables. Equation for each population is required as they can produce overestimation when manufacturer's equations are used. The classical measurements hand to foot has shown better correlation against hydrodensitometry than foot to foot or hand to hand. However there is a lack for an accepted standard of BIA procedures. This is compounded when there is not a good report of the BIA study's methodology; hence the comparability between the results is poor and reduces the reliability of the method. Perhaps, standardization of methods would be the first step for BIA studies to move forward and subsequently improve its accuracy. Standardized procedures could also minimize the impact of these variables on studies results. The aim of this study was to propose a protocol as a checklist to standardize BIA procedures and produce comparable results from future studies performed with the classic hand-foot configuration in adults.

González-Correa, C. H.; Caicedo-Eraso, J. C.

2012-12-01

37

A chiral liquid chromatography method for the simultaneous determination of oxcarbazepine, eslicarbazepine, R-licarbazepine and other new chemical derivatives BIA 2-024, BIA 2-059 and BIA 2-265, in mouse plasma and brain.  

UK PubMed Central (United Kingdom)

Recently, in silico models have been developed to predict drug pharmacokinetics. However, before application, they must be validated and, for that, information about structurally similar reference compounds is required. A chiral liquid chromatography method with ultraviolet detection (LC-UV) was developed and validated for the simultaneous quantification of BIA 2-024, BIA 2-059, BIA 2-265, oxcarbazepine, eslicarbazepine (S-licarbazepine) and R-licarbazepine in mouse plasma and brain. Compounds were extracted by a selective solid-phase extraction procedure and their chromatographic separation was achieved on a LiChroCART 250-4 ChiraDex column using a mobile phase of water-methanol (92:8, v/v) pumped at 0.7?mL/min. The UV detector was set at 235?nm. Calibration curves were linear (r(2) ???0.996) over the concentration ranges of 0.2-30?µg/mL for oxcarbazepine, eslicarbazepine and R-licarbazepine; 0.2-60?µg/mL for the remaining compounds in plasma; and 0.06-15?µg/mL for all the analytes in brain homogenate. Taking into account all analytes at these concentration ranges in both matrices, the overall precision did not exceed 9.09%, and the accuracy was within ±14.3%. This LC-UV method is suitable for carrying out pharmacokinetic studies with these compounds in mouse in order to obtain a better picture of their metabolic pathways and biodistribution.

Fortuna A; Alves G; Almeida A; Lopes B; Falcão A; Soares-da-Silva P

2012-03-01

38

Determinação rápida de hidroquinona usando análise por injeção em batelada (BIA) com detecção amperométrica/ Fast determination of hydroquinone by batch injection analysis (BIA) with amperometric detection  

Scientific Electronic Library Online (English)

Full Text Available Abstract in english A fast analytical method for determination of hydroquinone in pharmaceutical formulations employing batch injection analysis (BIA) with amperometric detection using a boron-doped diamond electrode is described. The supporting electrolyte was a 0.1 mol L-1 H2SO4 solution (the single reagent used for analysis). The method showed good repeatability (RSD of 0.45%, n=20), wide linear range (from 10 to 2000 µmol L-1, R=0.9999), low detection limit (0.016 µmol L-1) and satisfa (more) ctory recovery values (91-96%). Accuracy of the method was evaluated by comparative analyses using high-performance liquid-chromatography. The ability to replace the electronic pipette by disposable syringes (injection procedure) in BIA systems was also shown.

Cunha, Rafael Rodrigues; Tormin, Thiago Faria; Richter, Eduardo Mathias; Munoz, Rodrigo Alejandro Abarza

2013-01-01

39

Ci??ka posta? alergii na bia?ka mleka krowiego - przypadek kliniczny  

Directory of Open Access Journals (Sweden)

Full Text Available Alergia na bia?ka mleka krowiego dotyczy nawet 5% niemowl?t i jest jednym z g?ównych problemów dla rodziców i pediatrów. Dost?pne krajowe i mi?dzynarodowe wytyczne definiuj? zasady jej rozpoznania i leczenia. Zdarzaj? si? jednak dzieci, które wymagaj? zindywidualizowanego podej?cia. Jeden z takich przypadków zaprezentowano poni?ej.

?ukasz Dembi?ski; Maria Kotowska; Piotr Albrecht

2012-01-01

40

Evaluation of fluid balance and dry weight with BIA in patients with maintenance hemodialysis  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Objective: To evaluate the fluid balance and dry weight with whole body bioelectrical impedance analysis (BIA) in patients with maintenance hemodialysis (MHD). Methods: Twenty patients in stable condition with MHD for more than one year were selected (MHD group). Extra-cellular water (ECW) and intra...

Lu, W; Ji, G; Chen, SJ; Wu, GF; Jiang, GR

 
 
 
 
41

Skeletal muscle mass in hospitalized elderly patients: Comparison of measurements by single-frequency BIA and DXA.  

UK PubMed Central (United Kingdom)

BACKGROUND & AIMS: There is increasing interest in estimating skeletal muscle mass (SMM) in clinical practice. We aimed to validate a bioelectrical impedance analysis (BIA) prediction equation for SMM, developed in a different healthy elderly population, in a population of hospital patients aged 70 and over, by comparison with dual-energy X-ray absorptiometry (DXA) SMM estimates. Comparison was also made with two other previously published BIA muscle prediction equations. METHODS: Muscle measurements by BIA and DXA were compared in 117 patients with a range of clinical conditions (45 female, 72 male, mean age 75 years). RESULTS: The BIA equation used yielded an accurate estimate of DXA-derived SMM. Mean (SD) difference was 0.26(1.79) kg (ns). The two other BIA equations over-estimated SMM compared to DXA (both p < 0.001), but all equations were highly correlated. CONCLUSIONS: The BIA equation used, developed in a different healthy elderly population, gave an accurate estimate of DXA-derived SMM in a population with various clinical disorders. BIA appears potentially capable to estimate SMM in clinical disorders, but the optimal approach to its use for this purpose requires further investigation.

Bosaeus I; Wilcox G; Rothenberg E; Strauss BJ

2013-06-01

42

Pharmacokinetics and pharmacodynamics of BIA 3-202, a novel COMT inhibitor, during first administration to humans.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To determine the tolerability, pharmacodynamics and pharmacokinetics of single oral doses of BIA 3-202, a novel catechol-O-methyltransferase (COMT) inhibitor, in healthy male volunteers. METHODS: Single increasing oral doses of BIA 3-202 (10, 30, 50, 100, 200, 400 and 800mg) were administered under fasting conditions to seven sequential groups of nine subjects, under a double-blind, randomised, placebo-controlled design. In an additional group of eight subjects (group 8), a single dose of BIA 3-202 400mg was administered on two occasions, once under fasting conditions and once with a high-fat meal, under an open-label, two-way crossover design. RESULTS: BIA 3-202 was well tolerated at all doses tested. Most adverse events were mild in severity and their incidence was similar between BIA 3-202 and placebo. Maximum plasma concentrations (C(max)) of BIA 3-202 were attained at 0.5-2.5h (t(max)) and thereafter declined with an apparent terminal half-life (t(1/2)) of 1.5-5h. Over the dose range of 10-800mg, there was an approximately dose-proportional increase in the area under the plasma concentration-time curve (AUC) values of BIA 3-202: for a dose level increase in the ratio 3.0:1.7:2.0:2.0:2.0:2.0, AUC increased in the ratio 3.1:1.7:1.9:2.2:2.1:1.7. Plasma concentrations of the O-methylated derivative, BIA 3-270, increased markedly less than predicted from a proportional relationship: for a dose level increase in the ratio 1:80, AUC(0-t )increased in the ratio 1:5. In most subjects, the t(max) of BIA 3-270 was attained at the last sampling time and, therefore, t(1/2 )could not be estimated. Urine assays showed that less than 1% of the total dose administered was excreted in urine as BIA 3-202. Urine concentrations of BIA 3-270 were below the limit of quantification. In group 8, the rate and extent of systemic availability (t(max), AUC and C(max)) of BIA 3-202 and BIA 3-270 after a high-fat meal were similar to those under fasting conditions. Inhibition of COMT activity in erythrocytes reached maximum levels at 2-2.5h post dose, with sustained inhibition up to approximately 4-6 hours, returning to baseline by about 16 hours. CONCLUSION: BIA 3-202 was well tolerated at single 10-800mg oral doses and presented dose-proportional kinetics. It effectively inhibited COMT activity and the presence of food did not affect its pharmacokinetics or COMT inhibitory activity. The results provide a basis for further clinical studies with BIA 3-202.

Almeida L; Soares-da-Silva P

2003-01-01

43

Czynniki ryzyka, epidemiologia i klinika grzybic w ostrych bia?aczkach  

Directory of Open Access Journals (Sweden)

Full Text Available Chorzy na ostre bia?aczki s? predysponowani do rozwoju infekcji grzybiczych w wyniku ilo?ciowego i jako?ciowego uszkodzenia granulocytów i mono-cytów, pog??biaj?ce si? w toku choroby i leczenia. Uszkodzone ?luzówki s? wrotami infekcji, stanowi? ognisko zaka?enia i miejsce wyj?cia systemowej inwazji. Diagnostyczne i terapeutyczne procedury (np. cewniki naczyniowe) zwi?kszaj? równie? ryzyko zaka?enia. Mimo i? najcz?stszym patoge-nem grzybiczym jest Candida albicans, wzrasta liczba infekcji wywo?anych przez inne szczepy Candida. Rodzaj Aspergillus jest drugim co do cz?sto?ci wyst?powania patogenem grzybiczym, cechuj?cym si? inwazj? naczy? z wytworzeniem w nich zakrzepów, podobnie jak w rzadziej wyst?puj?cym zaka?eniu Mucor. Znajomo?? obrazu klinicznego grzybic i identyfikacja patogenu s? potrzebne do podj?cia w?a?ciwego rozpoznania i leczenia grzybic w ostrych bia?aczkach.

Jadwiga Nowicka

2003-01-01

44

Design and Development of a Portable WiFi enabled BIA device  

Science.gov (United States)

A bioimpedance device (BIA) for evaluation of sarcopenia - age related muscle mass loss - is designed, developed and evaluated. The requirements were based on lightweight design, flexible and user enabled incorporation of measurement protocols and WiFi protocol for remote device control, full internet integration and fast development and usage of measurement protocols. The current design is based on usage of a microcontroller with integrated AD/DA converters. The prototype system was assembled and the operation and connectivity to different handheld devices and laptop computers was successfully tested. The designed BIA device can be accessed using TCP sockets and once the connection is established the data transfer runs successfully at the specified speed. The accuracy of currently developed prototype is about 5% for the impedance modulus and 5 deg. for the phase for the frequencies below 20 kHz with an unfiltered excitation signal and no additional amplifiers employed.

Križaj, D.; Baloh, M.; Brajkovi?, R.; Žagar, T.

2013-04-01

45

Inwazyjne zaka?enia grzybicze o trudnym przebiegu w trakcie leczenia ostrej bia?aczki limfoblastycznej  

Directory of Open Access Journals (Sweden)

Full Text Available Inwazyjne zaka?enia grzybicze (IZG) u dzieci z rozpoznan? ostr? bia?aczk? limfoblastyczn? (ALL) stanowi? trudny problem diagnostyczny i terapeutyczny. W niniejszej pracy przed stawiono 2 pacjentki z ALL oraz zlokalizowanym inwazyjnym zaka?eniem grzybiczym zdiagnozowanym typowo, podczas przebiegu gor?czki neutropenicznej. Mimo wczesnej terapii przeciwgrzybiczej, jedna z pacjentek, 3-letnia dziewczynka,zmar?a z powodu progresji IZG.

Gra?yna Sobol; Katarzyna Musio?; Agnieszka Mizia-Malarz; Weronika Stolpa; Ma?gorzata Krupa; Anna Szyszka; El?bieta Kuleta; Ewa Walczak; Ludwik Sto?tny; Halina Wo?

2009-01-01

46

Bioelectrical impedance analysis in clinical practice: implications for hepatitis C therapy BIA and hepatitis C  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Body composition analysis using phase angle (PA), determined by bioelectrical impedance analysis (BIA), reflects tissue electrical properties and has prognostic value in liver cirrhosis. Objective of this prospective study was to investigate clinical use and prognostic value of BIA-derived phase angle and alterations in body composition for hepatitis C infection (HCV) following antiviral therapy. Methods 37 consecutive patients with HCV infection were enrolled, BIA was performed, and PA was calculated from each pair of measurements. 22 HCV genotype 3 patients treated for 24 weeks and 15 genotype 1 patients treated for 48 weeks, were examined before and after antiviral treatment and compared to 10 untreated HCV patients at 0, 24, and 48 weeks. Basic laboratory data were correlated to body composition alterations. Results Significant reduction in body fat (BF: 24.2 ± 6.7 kg vs. 19.9 ± 6.6 kg, genotype1; 15.4 ± 10.9 kg vs. 13.2 ± 12.1 kg, genotype 3) and body cell mass (BCM: 27.3 ± 6.8 kg vs. 24.3 ± 7.2 kg, genotype1; 27.7 ± 8.8 kg vs. 24.6 ± 7.6 kg, genotype 3) was found following treatment. PA in genotype 3 patients was significantly lowered after antiviral treatment compared to initial measurements (5.9 ± 0.7° vs. 5.4 ± 0.8°). Total body water (TBW) was significantly decreased in treated patients with genotype 1 (41.4 ± 7.9 l vs. 40.8 ± 9.5 l). PA reduction was accompanied by flu-like syndromes, whereas TBW decline was more frequently associated with fatigue and cephalgia. Discussion BIA offers a sophisticated analysis of body composition including BF, BCM, and TBW for HCV patients following antiviral regimens. PA reduction was associated with increased adverse effects of the antiviral therapy allowing a more dynamic therapy application.

Kahraman Alisan; Hilsenbeck Johannes; Nyga Monika; Ertle Judith; Wree Alexander; Plauth Mathias; Gerken Guido; Canbay Ali E

2010-01-01

47

Rozsiana fuzarioza u pacjentki z ostr? bia?aczk? limfoblastyczn? grupy wysokiego ryzyka  

Directory of Open Access Journals (Sweden)

Full Text Available Rozsiana fuzarioza (RF) jest ci??kim i zagra?aj?cym ?yciu powik?aniem infekcyjnym wyst?puj?cym przede wszystkim u pacjentów z g??bokimi deficytami odporno?ci. Opisano przypadek 14-letniej dziewczynki z ostr? bia?aczk? limfoblastyczn? grupy wysokiego ryzyka, u której bezpo?rednio po bloku HR-1 programu ALLIC BFM 2002 rozpoznano rozsian? fuzarioz? (skóra, p?uca, przewód pokarmowy). Dzi?ki intensywnemu leczeniu przeciwgrzybiczemu (skojarzona terapia worykonazolem i kaspofungin?) uzyskano zdecydowan? popraw? stanu dziecka. W 45. dobie od momentu rozpoznania zaka?enia grzybiczego rozpoznano wznow? ostrej bia?aczki. Rozpocz?to leczenie cytostatyczne, prowadz?c jednocze?nie leczenie przeciwgrzybicze. Mimo intensywnej terapii dosz?o do rozwoju zaka?enia uogólnionego i zgonu dziecka w przebiegu niewydolno?ci wielonarz?dowej. Fuzarioza jest rzadkim rodzajem zaka?enia u dzieci z ostr? bia?aczk?, musi by? jednak brana pod uwag?, szczególnie u pacjentów z grup wysokiego ryzyka. Worykonazol i kaspofungina podawane razem wydaj? si? skutecznymi lekami w leczeniu fuzariozy u dzieci.

Tomasz Ociepa; Eliza Maloney; Karolina Zielezi?ska; Tomasz Urasi?ski

2009-01-01

48

Functionalization of amorphous SiO? and 6H-SiC(0001) surfaces with benzo[ghi]perylene-1,2-dicarboxylic anhydride via an APTES linker.  

Science.gov (United States)

The successful covalent functionalization of quartz and n-type 6H-SiC with organosilanes and benzo[ghi]perylene-1,2-dicarboxylic dye is demonstrated. In particular, wet-chemically processed self-assembled layers of aminopropyltriethoxysilane (APTES) and benzo[ghi]perylene-1,2-dicarboxylic anhydride are investigated. The structural and chemical properties of these layers are studied by contact angle measurements, attenuated total reflection infrared (ATR-IR) spectroscopy, and X-ray photoelectron spectroscopy (XPS). The optical properties are measured by confocal microscopy. The wetting angles observed for the organic layers are ? = 68° for the APTES-functionalized surface, while angles of ? = 85° and 78° are determined for dye-functionalized quartz and 6H-SiC surfaces, respectively. However, not all amino groups of the APTES-functionalized surfaces react to bind dye molecules. Further dye functionalization is not uniform throughout the surface, showing different island sizes of the dye and including different chemical environments. The quartz surface exhibits a higher packing density of dyes than the 6H-SiC surface. The fluorescence lifetimes of the surface-attached dye show double exponential decays of about 1.4 and 4.2 ns, largely independent of the substrates. PMID:22262648

Bhowmick, Deb Kumar; Linden, Steffen; Devaux, André; De Cola, Luisa; Zacharias, Helmut

2012-01-19

49

Functionalization of amorphous SiO? and 6H-SiC(0001) surfaces with benzo[ghi]perylene-1,2-dicarboxylic anhydride via an APTES linker.  

UK PubMed Central (United Kingdom)

The successful covalent functionalization of quartz and n-type 6H-SiC with organosilanes and benzo[ghi]perylene-1,2-dicarboxylic dye is demonstrated. In particular, wet-chemically processed self-assembled layers of aminopropyltriethoxysilane (APTES) and benzo[ghi]perylene-1,2-dicarboxylic anhydride are investigated. The structural and chemical properties of these layers are studied by contact angle measurements, attenuated total reflection infrared (ATR-IR) spectroscopy, and X-ray photoelectron spectroscopy (XPS). The optical properties are measured by confocal microscopy. The wetting angles observed for the organic layers are ? = 68° for the APTES-functionalized surface, while angles of ? = 85° and 78° are determined for dye-functionalized quartz and 6H-SiC surfaces, respectively. However, not all amino groups of the APTES-functionalized surfaces react to bind dye molecules. Further dye functionalization is not uniform throughout the surface, showing different island sizes of the dye and including different chemical environments. The quartz surface exhibits a higher packing density of dyes than the 6H-SiC surface. The fluorescence lifetimes of the surface-attached dye show double exponential decays of about 1.4 and 4.2 ns, largely independent of the substrates.

Bhowmick DK; Linden S; Devaux A; De Cola L; Zacharias H

2012-02-01

50

Validation of bioelectrical impedance analysis (BIA) for estimation of body composition in Black, White and Hispanic adolescent girls.  

UK PubMed Central (United Kingdom)

AIM: Equations for estimating % fat mass (%BF) and fat-free mass (FFM) from bioelectrical impedance analysis (BIA) that work in adolescent girls from different racial/ethnic backgrounds are not available. We investigated whether race/ethnicity influences estimation of body composition in adolescent girls. PRINCIPAL PROCEDURES: Prediction equations were developed for estimating FFM and %BF from BIA in 166 girls, 10-15 years old, consisting of 51 Black (B), 45 non-Black Hispanic (H), 55 non-Hispanic White (W) and 15 mixed (M) race/ethnicity girls, using dual energy x-ray absorptiometry (DXA) as the criterion method. FINDINGS: Black girls had similar %BF compared to other groups, yet were heavier per unit of height according to body mass index (BMI: kg.m(-2)) due to significantly greater FFM. BIA resistance index, age, weight and race/ethnicity were all significant predictors of FFM (R(2) = 0.92, SEE = 1.81 kg). Standardized regression coefficients showed resistance index (0.63) and weight (0.34) were the most important predictors of FFM. Errors in %BF (~2%) and FFM (~1.0 kg) were greater when race/ethnicity was not included in the equation, particularly in Black girls. We conclude the BIA-composition relationship in adolescent girls is influenced by race, and consequently have developed new BIA equations for adolescent girls for predicting FFM and %BF.

Going S; Nichols J; Loftin M; Stewart D; Lohman T; Tuuri G; Ring K; Pickrel J; Blew R; J Stevens

2006-01-01

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Systemy ekspresyjne bia?ek cytochromu P450 w badaniach in vitro metabolizmu leków  

Directory of Open Access Journals (Sweden)

Full Text Available Bia?ka cytochromu P450 to najwa?niejsze enzymy bior?ce udzia? w metabolizmie wi?kszo?ci stosowanych w klinice leków, odpowiedzialne za ich aktywacj? lub detoksykacj?. Niektóre z dróg metabolizmu leku mog? by? jednak odpowiedzialne za jego podwy?szon? toksyczno??. Nowe systemy ekspresyjne bia?ek cytochromu P450 w komórkach ssaków, w tym cz?owieka, projektowane s? w celu poznania roli metabolizmu w mechanizmie dzia?ania potencjalnych, jak i stosowanych w klinice leków, zarówno na poziomie molekularnym, jak i komórkowym. Mog? te? s?u?y? do badania wp?ywu badanych zwi?zków na aktywno?? i ekspresj? enzymów metabolizuj?cych. Szczególne znaczenie, zw?aszcza w badaniach potencjalnych chemioterapeutyków, maj? ludzkie nowotworowe linie komórkowe wykazuj?ce nadekspresj? izoenzymów cytochromu P450. W badaniach nad metabolizmem i toksyczno?ci? leków najcz??ciej stosowan? lini? komórkow? jest ludzka linia HepG2 wyprowadzona z nowotworu w?troby. Ze wzgl?du jednak na niski poziom enzymów metabolizuj?cych w tych komórkach, opracowano lini? komórkow? Hep3A4, która charakteryzowa?a si? podwy?szon? ekspresj? izoenzymu CYP3A4. Stabiln? nadekspresj? izoenzy­mów cytochromu P450 uzyskano równie? w komórkach kolejnej linii wyprowadzonej z ludzkiego nowotworu w?troby, HepaRG oraz w komórkach linii IGROV-1, wywodz?cych si? z nowotworu jajnika, a tak?e dwóch linii wyprowadzonych z nowotworu okr??nicy: Caco-2 i LS180. W pracy przedstawiono dotychczas opracowane systemy ekspresyjne bia?ek cytochromu P450 – modele: bakteryjny, dro?d?owy, owadzi i ssaczy, w tym ludzki, z uwzgl?dnieniem ich zalet i wad pod k?tem przydatno?ci do bada? podstawowych, jak i wykorzystania na skal? komercyjn?.

Monika Paw?owska; Ewa Augustin

2011-01-01

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Coproscopical investigations of the European otter (Lutra lutra) from Bia?owieza Primeval Forest.  

Science.gov (United States)

The parasitofauna of the European otter (Lutra lutra) remains poorly known in Poland. In the presented study 106 fecal samples from otters living in the Bia?owieza Primeval Forest were examined, using standard flotation and sedimentation methods. We found that the overall prevalence of parasitic infections was 30.1%. Eggs of Alaria alata (0.9%), Opistorchis or Metorchis sp. (5.7%), Diphyllobothrium latum (1.9%) and Aonchotheca putori (1.9%) were identified, but in other cases the species of parasite could not be reliably determined. Parasitological dissections should give better results in future studies. PMID:20707304

Górski, Pawe?; Zalewski, Andrzej; Kazimierczak, Katarzyna; Kotomski, Grzegorz

2010-01-01

53

Evidence for an EPR-detectable semiquinone intermediate stabilized in the membrane-bound subunit NarI of nitrate reductase A (NarGHI) from Escherichia coli.  

Science.gov (United States)

Nitrate reductase A (NRA, NarGHI) is expressed in Escherichia coli by growing the bacterium in anaerobic conditions in the presence of nitrate. This enzyme reduces nitrate to nitrite and uses menaquinol (or ubiquinol) as the electron donor. The location of quinones in the enzyme, their number, and their role in the electron transfer mechanism are still controversial. In this work, we have investigated the spectroscopic and thermodynamic properties of a semiquinone (SQ) in membrane samples of overexpressed E. coli nitrate reductase poised in appropriate redox conditions. This semiquinone is highly stabilized with respect to free semiquinone. The g-values determined from the numerical simulation of its Q-band (35 GHz) EPR spectrum are equal to 2.0061, 2.0051, 2.0023. The midpoint potential of the Q/QH(2) couple is about -100 mV, and the SQ stability constant is about 100 at pH 7.5. The semiquinone EPR signal disappears completely upon addition of the quinol binding site inhibitor 2-n-nonyl-4-hydroxyquinoline N-oxide (NQNO). A semiquinone radical could also be stabilized in preparations where only the NarI membrane subunit is overexpressed in the absence of the NarGH catalytic dimer. Its thermodynamic and spectroscopic properties show only slight variations with those of the wild-type enzyme. The X-band continuous wave (cw) electron nuclear double resonance (ENDOR) spectra of the radicals display similar proton hyperfine coupling patterns in NarGHI and in NarI, showing that they arise from the same semiquinone species bound to a single site located in the NarI membrane subunit. These results are discussed with regard to the location and the potential function of quinones in the enzyme. PMID:15667223

Grimaldi, Stéphane; Lanciano, Pascal; Bertrand, Patrick; Blasco, Francis; Guigliarelli, Bruno

2005-02-01

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Rola alergii na bia?ka mleka krowiego w etiopatogenezie przewlek?ych bólów brzucha u dzieci  

Directory of Open Access Journals (Sweden)

Full Text Available Wprowadzenie: W ostatnich latach pojawi?y si? doniesienia i? alergia pokarmowa mo?e by? jednym z czynników wywo?uj?cych nawracaj?ce bóle brzucha u dzieci. Cel: Celem pracy by?a ocena udzia?u alergii na bia?ka mleka krowiego w patogenezie nawracaj?cych bólów brzucha u dzieci powy?ej 7 r.?. Metody: Badaniami obj?to 87 dzieci, ?rednia wieku 11,9 lat, od 7 do 18 lat, przyj?tych do kliniki z powodu nawracaj?cych bólów brzucha. U badanych oznaczono st??enie IgE ca?kowitej, IgE specyficznej dla bia?ek mleka krowiego, przeprowadzono testy skórne z mlekiem krowim, a nast?pnie wykonano prowokacj? pokarmow? z zastosowaniem podwójnie ?lepej próby kontrolowanej placebo. Wyniki: IgE ca?kowite by?o podwy?szone u 17 (19,5%) badanych. U ?adnego pacjenta nie stwierdzono IgE specyficznych dla bia?ek mleka krowiego, testy skórne z mlekiem krowim by?y ujemne u wszystkich badanych dzieci. Prowokacja pokarmowa mlekiem wypad?a dodatnio u 8 dzieci. Wnioski: IgE-niezale?na alergia na bia?ka mleka krowiego mo?e by? przyczyn? nawracaj?cych bólów brzucha u dzieci starszych.

El?bieta Jarocka-Cyrta; Miros?awa U?cinowicz; Jolanta Wasilewska; Maciej Kaczmarski

2002-01-01

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25 CFR 115.601 - Under what circumstances may the BIA restrict your IIM account through supervision or an...  

Science.gov (United States)

...account through supervision if the BIA: (1) Receives an order from a court of competent jurisdiction that you are non-compos mentis; or (2) Receives an order or judgment from a court of competent jurisdiction that you are an adult in need of...

2009-04-01

56

Evaluation of bioelectrical impedance analysis (BIA) to measure condition and energy allocated to reproduction in marine fishes  

Science.gov (United States)

Reliable estimates of fish energy density at specific times prior to spawning may provide suitable proxies for egg production, and thereby help to explain some of the observed annual variation in recruits per spawner. Our goal is to develop and test modifications of BIA technology to measure energy allocation to reproduction for a variety of marine fishes. To date, a newly developed measuring board and probe system stabilized readings, which was demonstrated by a significant reduction in the coefficients of variation for impedance measures. Total body water, wet and dry weights could be predicted with very good precision (r2 = 0.92-0.99) using BIA measures of reactance or resistance for a number of finfish species. While constituent relationships (e.g. body water- body mass functions) did not differ seasonally, we did find that BIA measures are sensitive to body composition changes related to the seasonal spawning cycle. In an examination of monthly samples of tilefish, phase angle decreased below 15° in post-spawning (regressed) females. Such a monthly trend, which suggests available energy had decreased following the spawning season, was not evident from other, more traditional measures of condition including body-muscle water content, Fulton's K or ordinal measures of fat deposition (such as mesenteric fat). These preliminary results show that BIA technology is a promising application for tracking and efficiently predicting energetic condition of marine fishes.

Fitzhugh, G. R.; Wuenschel, M. J.; McBride, R. S.

2010-04-01

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St??enia bia?ek ostrej fazy u dzieci z wrzodziej?cym zapaleniem jelita grubego  

Directory of Open Access Journals (Sweden)

Full Text Available Wrzodziej?ce zapalenie jelita grubego (w.z.j.g.) jest nieswoistym, przewlek?ym i nawracaj?cym zapaleniem jelita, którego przyczyna nie zosta?a ustalona. Aktywno?? choroby najcz??ciej jest oceniana na podstawie objawów klinicznych oraz wyników wybranych bada? dodatkowych. Powszechnie stosowane metody diagnostyki laboratoryjnej nie pozwalaj? na monitorowanie przebiegu choroby w trakcie leczenia. Celem pracy by?a ocena dynamiki st??e? wybranych bia?ek ostrej fazy u dzieci z w.z.j.g. w ostrym rzucie choroby przed rozpocz?ciem leczenia, podczas jego stosowania i w trakcie remisji oraz okre?lenie przydatno?ci oznaczania bia?ek ostrej fazy w ocenie ci??ko?ci rzutu choroby. Badaniom poddano 36 dzieci (16 dziewcz?t i 20 ch?opców) w wieku 10-16 lat hospitalizowanych w II Klinice Chorób Dzieci Katedry Pediatrii WAM w ?odzi, u których rozpoznano wrzodziej?ce zapalenie jelita grubego. Dzieci, w zale?no?ci od ci??ko?ci rzutu choroby, podzielono na trzy grupy: do I grupy zaliczono 7 dzieci z ci??k? postaci? wrzodziej?cego zapalenia jelita grubego, do grupy II – 17 dzieci ze ?rednioci??k? postaci? choroby, a do grupy III – 12 dzieci z lekk? postaci? w.z.j.g. Grup? porównawcz? stanowi?o 30 zdrowych dzieci (14 dziewcz?t i 16 ch?opców) w tym samym wieku. W ostrym rzucie choroby oznaczenia wykonano przed leczeniem, w 4., 7., 14. i 21. dniu po jego zastosowaniu oraz w czasie remisji. U badanych dzieci w surowicy krwi oznaczano st??enie bia?ka C-reaktywnego (CRP), a1-antytrypsyny (AAT), a1-kwa?nej glikoproteiny (AAG) oraz bia?ka ca?kowitego i jego frakcji. Oznaczenia st??e? bia?ek ostrej fazy wykonano wed?ug immunochemicznej metody nefelometrii kinetycznej za pomoc? nefelometru firmy Behring, bia?ka ca?kowitego – wed?ug metody biuretowej z u?yciem aparatu typu Monarch, za? frakcji bia?kowych – wed?ug metody elektroforezy na 1-proc. ?elu agarozowym przy u?yciu systemu Paragon firmy Beckman. U dzieci, w zale?no?ci od ci??ko?ci rzutu choroby, stwierdzono statystycznie znamienny wzrost st??e? CRP, AAT i AAG, jak równie? obni?enie st??enia bia?ka ca?kowitego oraz albumin i podwy?szenie warto?ci st??e? a1-, a2- i b-globulin. Najwy?sze ?rednie st??enia oznaczanych bia?ek wyst?powa?y przed leczeniem, po czym nast?powa? stopniowy ich spadek do warto?ci prawid?owych podczas remisji. Ustalono, ?e zró?nicowana dynamika st??e? ocenianych bia?ek mo?e by? wykorzystana w monitorowaniu przebiegu choroby. Warto?ci dyskryminacyjne natomiast wyznaczone dla st??e? CRP, AAT i AAG wskazuj? na ich przydatno?? w ró?nicowaniu ci??ko?ci rzutu choroby.

Jolanta Lukamowicz; Krystyna Grzybowska; Bogus?awa Ujma-Kubasiewicz; Izabela P?aneta-Ma?ecka; Marek Paradowski; Agnieszka Skotnicka; Micha? Przybyszewski

1998-01-01

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Investigação de baixa estatura: aspectos clínicos, laboratoriais e moleculares da insensibilidade ao hormônio de crescimento Short stature investigation: clinical, laboratorial and genetic aspects concerning the trowth hormone insensitivity (GHI)  

Directory of Open Access Journals (Sweden)

Full Text Available Neste artigo são descritos os aspectos clínicos, laboratoriais e genéticos da investigação da baixa estatura, dando ênfase para o diagnóstico da insensibilidade ao hormônio de crescimento (IGH). O paciente apresentado possuía características clínicas típicas de pacientes com IGH e em idade pré-púbere seus achados laboratoriais eram compatíveis com este diagnóstico (IGF-1 e IGFBP3 baixos, GH basal e pós-estímulo elevados). No entanto, quando avaliado durante a puberdade, as dosagens de IGF-1 e IGFBP-3 foram normais, dificultando o diagnóstico. O estudo molecular identificou mutação no exon 7 do gene do receptor do hormônio de crescimento (S226I). Discutiram-se os passos realizados para identificar a mutação e demonstrar que ela é responsável pelo fenótipo observado no paciente. Também será feita revisão dos casos de IGH descritos no Brasil e dos novos defeitos moleculares descritos nesta doença.It is reported in this study the clinical, laboratory and genetic aspects of short stature investigation with emphasis to the diagnostic approach of growth hormone insensitivity (GHI). This patient in case presented typical clinical features of GHI and his laboratory findings at prepubertal age were typical of those observed in GHI patients (low IGF-1 and IGFBP-3 levels, with high basal and stimulated GH levels). However, during the puberty, he presented normal IGFBP-3 and IGF-1 levels that hindered the diagnosis. The molecular study disclosed a mutation in exon 7 of growth hormone receptor gene (S226I). The steps that demonstrated the causative effect of this mutation are shown here, and also a review of Brazilian GHI cases is given and new molecular defects in this field are discussed as well.

Alexander Augusto de Lima Jorge; Maria Adelaide Albergaria Pereira

2008-01-01

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Investigação de baixa estatura: aspectos clínicos, laboratoriais e moleculares da insensibilidade ao hormônio de crescimento/ Short stature investigation: clinical, laboratorial and genetic aspects concerning the trowth hormone insensitivity (GHI)  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese Neste artigo são descritos os aspectos clínicos, laboratoriais e genéticos da investigação da baixa estatura, dando ênfase para o diagnóstico da insensibilidade ao hormônio de crescimento (IGH). O paciente apresentado possuía características clínicas típicas de pacientes com IGH e em idade pré-púbere seus achados laboratoriais eram compatíveis com este diagnóstico (IGF-1 e IGFBP3 baixos, GH basal e pós-estímulo elevados). No entanto, quando avaliado dura (more) nte a puberdade, as dosagens de IGF-1 e IGFBP-3 foram normais, dificultando o diagnóstico. O estudo molecular identificou mutação no exon 7 do gene do receptor do hormônio de crescimento (S226I). Discutiram-se os passos realizados para identificar a mutação e demonstrar que ela é responsável pelo fenótipo observado no paciente. Também será feita revisão dos casos de IGH descritos no Brasil e dos novos defeitos moleculares descritos nesta doença. Abstract in english It is reported in this study the clinical, laboratory and genetic aspects of short stature investigation with emphasis to the diagnostic approach of growth hormone insensitivity (GHI). This patient in case presented typical clinical features of GHI and his laboratory findings at prepubertal age were typical of those observed in GHI patients (low IGF-1 and IGFBP-3 levels, with high basal and stimulated GH levels). However, during the puberty, he presented normal IGFBP-3 an (more) d IGF-1 levels that hindered the diagnosis. The molecular study disclosed a mutation in exon 7 of growth hormone receptor gene (S226I). The steps that demonstrated the causative effect of this mutation are shown here, and also a review of Brazilian GHI cases is given and new molecular defects in this field are discussed as well.

Jorge, Alexander Augusto de Lima; Pereira, Maria Adelaide Albergaria

2008-08-01

60

Problem diagnostyki mikologicznej u chorych z ostr? bia?aczk? oraz poddawanych przeszczepom szpiku  

Directory of Open Access Journals (Sweden)

Full Text Available Celem pracy by?o okre?lenie cz?sto?ci wyst?powania markerów zaka?enia grzybiczego: mannanu Candida, galaktomannanu Aspergillus, swoistych przeciwcia? anty-Aspergillus i anty-Candida w surowicach dzieci i doros?ych z ostr? bia?aczk? poddanych terapii przeciwnowotworowej oraz okre?lenie korelacji mi?dzy wyst?powaniem poszczególnych markerów a obecno?ci? klinicznych objawów zaka?enia. Grup? badan? stanowi?o 111 pacjentów -40 dzieci i 71 doros?ych. Antygeny oznaczano metod? lateksow? i testami ELISA, a przeciwcia?a hemaglutynacj? po?redni? {Aspergillus) i ELISA (Candida). Testem na obecno?? galaktomannanu Aspergillus zdiagnozowano inwazyjn? aspergiloz? (IA) u 1 dziecka po przeszczepie szpiku i u 2 doros?ych osób. U 4 osób (2 dzieci i 2 doros?ych), uzyskano wyniki fa?szywie dodatnie, a u 2 pacjentów, u których aspergiloz? potwierdzono badaniami hodowlanymi i mikroskopowymi, testy na obecno?? galaktomannanu pozostawa?y ujemne. Obecno?? mannanu stwierdzono u 10 chorych, wysokie (20 AU/ml) miana przeciwcia? anty-mannnan u 8 doros?ych chorych, przy czym u 5 z nich potwierdzono kandydoz? p?uc, a u pozosta?ych kandydoz? b?on ?luzowych. Uzyskane wyniki potwierdzaj?, ?e testy na obecno?? galaktomannanu s? u cz??ci chorych (zarówno dzieci jak i doros?ych) jedynym markerem umo?liwiaj?cym prze?yciowe ustalenie etiologii zaka?enia. W diagnostyce kandydozy u doros?ych pacjentów z ostr? bia?aczk? oprócz bada? na obecno?? mannanu nale?y uwzgl?dni? równie? badania poziomu przeciwcia? anty-mannan. Postawienie diagnozy grzybicy inwazyjnej (IFI) wymaga analizy stanu klinicznego, wyników bada? radiologicznych oraz mikologicznych z uwzgl?dnieniem testów serologicznych.

Urszula Nawrot; Jadwiga Nowicka; Katarzyna Juszczyk; Barbara Gusin

2003-01-01

 
 
 
 
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St??enie i mikroheterogenno?? bia?ek ostrej fazy u chorych z twardzin? uk?adow?  

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Full Text Available St??enie i mikroheterogenno?? bia?ek ostrej fazy (BOF) ulegazmianom w ostrych i przewlek?ych stanach zapalnych. Zmianyjako?ciowe niektórych bia?ek ostrej fazy s? okre?lane jako mikroheterogenno??g?ówna. Elektroforeza dwóch kierunków powinowactwaz konkanawalin? A (ConA) jako ligandem jest z powodzeniemstosowana do oceny mikroheterogenno?ci glikoproteinostrej fazy. Okre?lenie st??enia i mikroheterogenno?ci BOF mo?eby? u?yteczne we wczesnej diagnostyce i prognozowaniu przewlek?ychprocesów zapalnych, w tym twardziny uk?adowej (TU).Do badania zakwalifikowano 45 pacjentów z TU w ?rednim wieku46,2 roku. Wszyscy chorzy spe?niali kryteria klasyfikacyjne ARA dlarozpoznania twardziny uk?adowej. Grup? kontroln? stanowi?o15 zdrowych ochotników (?redni wiek 42,3 roku).St??enia kwa?nej glikoproteiny (AGP), antychymotrypsyny (ACT),ceruloplazminy (CP) by?y okre?lane w surowicy metod? elektroimmunoforezyz u?yciem przeciwcia? anty-AGP, anty-ACT, anty-CP.St??enie bia?ka C-reaktywnego (C-reactive protein – CRP) by?ookre?lane metod? radialnej immunodyfuzji z u?yciem przeciwcia?anty-CRP. Mikroheterogenno?? BOF oceniono metod? elektroforezydwóch kierunków z ConA na ?elu agarazowym, jak opisywa?Bo/g-Hansen. W grupie chorych z TU obserwowano zwi?kszeniest??enia kilku z badanych bia?ek ostrej fazy (AGP, CRP, CP). Umiarkowanezwi?kszenie st??enia CRP, AGP, CP obserwowano u 50%chorych z twardzin? uk?adow?, u których stwierdzono zapaleniestawów oraz owrzodzenia skóry. Bardzo du?e zwi?kszenie st??eniabia?ek ostrej fazy wyst?powa?o w grupie pacjentów z zaj?ciemserca i p?uc. Mikroheterogenno?? BOF by?a zmieniona u badanychchorych i wykazywa?a zmienne, niejednoznaczne obrazy. Wynikipotwierdzaj? obecno?? zmian w odpowiedzi ostrej fazy u chorychz twardzin? uk?adow?.

Izabela Domys?awska; Piotr A. Klimiuk; Agnieszka Sulik; Stanis?aw Sierakowski

2010-01-01

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Ropie? jamy brzusznej o etiologii Cryptococcus neoformans jako powik?anie leczenia ostrej bia?aczki promielocytarnej - opis przypadku  

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Full Text Available W pracy przedstawiono przebieg zaka?enia Cryptococcus neoformans zlokalizowanego w jelicie grubym u dziewczynki leczonej z powodu ostrej bia?aczki promielocytarnej (AML-M3), po perforacji wrzodu dwunastnicy i udarze niedokrwiennym mózgu. 10-tygodniowe leczenie lekami przeciwgrzybi-czymi by?o skuteczne. Dziecko do 2 lat pozostaje w ca?kowitej remisji choroby nowotworowej i bez objawów zaka?enia grzybiczego.

Barbara Sikorska-Fic; Agnieszka Bieja?

2004-01-01

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Density, degeneracy, delocalization-based index of aromaticity (D3BIA)  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese A aromaticidade tem sido exaustivamente discutida e continua sendo um tema misterioso. Nesse trabalho é proposto um novo índice de aromaticidade chamado índice baseado na densidade-degenerescência-deslocalização ou, simplesmente, D3BIA, numa tentativa de lançar nova introspecção sobre esse tema. Esse índice é baseado na teoria de átomos em moléculas (AIM) e, de certa forma, é suportado pela teoria dos spins acoplandos (SC). A aromaticidade diminui com o núm (more) ero de heteroátomos na molécula aromática, pois a degenerescência diminui, e diminui com o aumento do tamanho do anel do composto aromático porque desfavorece a sobreposição dos estados monoeletrônicos. A relação entre planaridade do anel, sua densidade eletrônica e aromaticidade é também observada. A interação atrativa da ressonância de 6 elétrons pi no diânion ciclobutadieno compensa sua interação repulsiva carbono-carbono enquanto no seu parente dicatiônico a ressonância de 2 elétrons pi é insuficiente para contrabalancear sua interação repulsiva e adota uma estrutura não-plana. Abstract in english Aromaticity has been exhaustedly discussed for several years and it remains as a misterious issue. In this work it is proposed a new index of aromaticity named density, degeneracy and delocalization-based index of aromaticity or simply D3BIA in an attempt to cast new insight and perspective over this theme. This index is based on AIM (atoms in molecules) theory and it is somewhat supported by SC (spin-coupled) theory. Aromaticity decreases as the number of heteroatoms in (more) the aromatic molecule increases since degeneracy decreases and it decreases as the ring size of an aromatic compound increases because it disfavors overlap of single-electron states. The relation between planar structures, electron density and aromaticity is also observed. The attractive interaction of 6pi-electron resonance in cyclobutadiene dianion compensate its carbon-to-carbon repulsive interaction while in its dicationic parent the 2pi-electron resonance is insufficient to counterbalance its carbon-to-carbon repulsive interaction and it adopts a puckered structure.

Firme, Caio L.; Galembeck, Sergio E.; Antunes, O. A. C.; Esteves, Pierre M.

2007-01-01

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Bioelectrical impedance analysis (BIA) for sarcopenic obesity (SO) diagnosis in young female subjects  

Science.gov (United States)

Sarcopenia is defined as a loss of muscle mass depending of ageing and affecting physical function (definition A). A new definition considers excluding mass reduction criterion (definition B). Obesity is pandemic and occurs at all ages. Sarcopenic obesity (SO) implies both processes. The purpose of this study was to compare the results obtained after applying these 2 definitions in 66 aged 22 ± 2.8 years overweight or obese young college women. Percentage body fat (%BF) and skeletal mass index (SMI) were estimated by BIA, muscle function by handgrip strength test (HGS) and physical performance by Harvard step test (HST). There were 9.1% and 90.9% overweight or obese subjects. Twenty nine subjects (43.9%) had decreased HGS and 22 (33.3%) had impaired physical performance. One obese subject (1.5%) met the criteria for sarcopenic obesity by definition A and 9 (13.6%) by definition B. Although a linear regression (? HGS, HST and SMI deterioration when %BF increases. However, other confounding factors must be investigated. Probably as the population gets more obese, the problematic of SO will be found earlier in life.

González-Correa, C. H.; Caicedo-Eraso, J. C.; S, Villada-Gomez J.

2013-04-01

65

Effect of food on the pharmacokinetic profile of etamicastat (BIA 5-453).  

UK PubMed Central (United Kingdom)

BACKGROUND: Etamicastat is a novel, potent, and reversible peripheral dopamine-?-hydroxylase inhibitor that has been administered orally at doses up to 600?mg once daily for 10 days to male healthy volunteers and appears to be well tolerated. OBJECTIVE: The aim of this study was to investigate the effect of food on the pharmacokinetics of etamicastat. MATERIAL AND METHODS: A single-center, open-label, randomized, two-way crossover study in 12 healthy male subjects was performed. Subjects were administered a single dose of etamicastat 200?mg following either a standard high-fat and high-calorie content meal (test) or 10 hours of fasting (reference). The statistical method for testing the effect of food on the pharmacokinetic parameters of interest was based upon the 90% confidence interval (CI) for the test/reference geometric mean ratio (GMR). The parameters of interest were maximum plasma concentration (C(max)), area under the plasma concentration-time curve (AUC) from time zero to the last measurable concentration (AUC(last)), and AUC from time zero to infinity (AUC(?)). Bioequivalence was assumed when the 90% CI fell within the recommended acceptance interval (80, 125). RESULTS: Etamicastat C(max), AUC(last), and AUC(?) were 229?ng/mL, 1856?ng?·?h/mL, and 2238?ng?·?h/mL, respectively, following etamicastat in the fasting, and 166?ng/mL, 1737?ng?·?h/mL, and 2119?ng?·?h/mL, respectively, following etamicastat in the fed condition. Etamicastat test/reference GMR was 72.27% (90% CI 64.98, 80.38) for C(max), 93.59% (90% CI 89.28, 98.11) for AUC(last), and 96.47% (90% CI 91.67, 101.53) for AUC(?). Time to C(max) was prolonged by the presence of food (p?BIA 5-961 were 275?ng/mL, 1827?ng?·?h/mL, and 2009?ng?·?h/mL, respectively, in the fasting, and 172?ng/mL, 1450?ng?·?h/mL, and 1677?ng?·?h/mL, respectively, in the fed condition. BIA 5-961 test/reference GMR was 62.42% (90% CI 56.77, 68.63) for C(max), 79.41% (90% CI 56.77, 68.63) for AUC(last), and 83.47% (90% CI 76.62, 90.93) for AUC(?). A total of six mild to moderate unspecific adverse events were reported by four subjects. There was no clinically significant abnormality in laboratory assessments. CONCLUSION: Etamicastat was well tolerated. The C(max) of etamicastat decreased 28% following oral administration of etamicastat in the presence of food, while AUC remained within the pre-defined acceptance interval. The delay in absorption and decrease in peak exposure of etamicastat is not clinically significant, and therefore etamicastat could be administered without regard to meals. Trial Registration: EudraCT No. 2007-006530-33.

Vaz-da-Silva M; Nunes T; Rocha JF; Falcão A; Almeida L; Soares-da-Silva P

2011-01-01

66

Ró?nice w obrazie klinicznym jelitowej ucieczki bia?ka oraz u?yteczno?? alfal-antytrypsyny w diagnostyce i monitorowaniu leczenia  

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Full Text Available Jelitowa ucieczka bia?ka (protein-losing enteropathy - PLE) jest objawem wielu chorób, zarówno przewodu pokarmowego, jak i chorób ogólnoustrojowych. Przedstawiamy grup? 6 dzieci z jelitow? ucieczk? bia?ka na pod?o?u ró?nych chorób: wrodzonego zespo?u naczynia-kowato?ci limfatycznej, choroby Le?niowskiego-Crohna oraz po operacji kardiochirurgicznej. Jelitowa ucieczka bia?ka zosta?a rozpoznana na podstawie oznaczenia alfal-antytrypsyny (alfa1-AT) w kale. Przedmiotowo objawia?a si? ona obrz?kami o ró?nej lokalizacji i nasileniu, a w badaniach laboratoryjnych hipoproteinemi?z hipoalbuminemi?, a tak?e hipokalcemi?. W badanej grupie chorych zaobserwowano korelacj? mi?dzy nasileniem zmian chorobowych a poziomem alfal-antytrypsyny w kale oraz u?yteczno?? jej oznaczania w monitorowaniu leczenia.

Piotr Socha; Grzegorz Oraczy Ma?gorzata Kowalska; Anna Rybak; Józef Ry?ko; Jerzy Socha

2005-01-01

67

Kinaza bia?ka p38 aktywowana przez mitogen - nowy molekularny sposób terapii przeciwzapalnej w chorobie Crohna  

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Full Text Available Badanie choroby zapalnej jelit (IBD) przez mi?dzykomórkow? transdukcjÍ sygna?u ze specyficzn? regulacj? genu stworzy?o szerokie pole dla nowych zwi?zków terapeutycznych. Kinazy bia?ka aktywowane przez mitogen (MAPK) odgrywaj? kluczow? rol? w wielu procesach fizjologicznych, w tym w ró?nicowaniu, przemieszczaniu, podziale i obumieraniu komórek. U ssaków MAPK s? g?ównymi mediatorami mi?dzykomórkowej transdukcji sygna?u od bod?ców pozakomórkowych do transkrypcji genów w komórkach zapalnych. W tym artykule podsumowujemy ostatnie osi?gni?cia w zrozumieniu roli MAPK w chorobie zapalnej jelit i omawiamy nowe metody leczenia.

Elke Hollenbach; Michael Naumann; Peter Malfertheiner

2003-01-01

68

Metody badania autofagii oparte na przemianach bia?ek MAP1LC3 i p62/SQSTM1   

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Full Text Available Autofagia jest procesem katabolicznym o fundamentalnym znaczeniu dla przetrwania okresów niedoborów sk?adników od?ywczych i w recyklingu organelli komórkowych. W ostatnim czasie obserwuje si? bardzo znacz?cy wzrost zainteresowania badaniem autofagii, a zaburzenia w jej przebiegu towarzysz? wielu chorobom. Niestety, warsztat jakim dysponujemy w badaniu autofagii pozostaje stosunkowo ma?o znany i ubogi. W pracy omówiono najcz??ciej stosowane metody badania autofagii. Oprócz mikroskopii elektronowej przedstawiono metody (fluorescencyjnei Western blotting) oparte na obserwacji przemian bia?ek MAP1LC3 i p62/SQSTM – nale??cych do podstawowych markerów autofagii.

Edyta Wysoki?ska,; Wojciech Ka?as

2013-01-01

69

An HPLC-DAD method for the simultaneous quantification of opicapone (BIA 9-1067) and its active metabolite in human plasma.  

Science.gov (United States)

Opicapone (BIA 9-1067) is a novel catechol-O-methyltransferase inhibitor presently under clinical development as an adjuvant in the pharmacotherapy of Parkinson's disease. This report describes the development and validation of a bioanalytical assay for the simultaneous quantification of opicapone and its active metabolite (BIA 9-1079) in human plasma. The method herein reported is based on high-performance liquid chromatography coupled with diode-array detection (HPLC-DAD) and the sample preparation consists of a plasma protein precipitation step followed by liquid-liquid extraction. Chromatographic separation of the analytes (opicapone and BIA 9-1079) and the internal standard (tamoxifen) was achieved in less than 10 min on a reversed-phase C18 column at 25 °C by applying a gradient elution program using a mobile phase composed of 0.05 M monosodium phosphate solution adjusted to pH 2.45 (A) and acetonitrile (B) pumped at 0.8 mL min(-1). Opicapone and the internal standard were monitored at 271 nm while BIA 9-1079 was assessed at 257 nm. Calibration curves of both analytes were linear (r(2) ? 0.997) in the concentration range of 25-3000 ng mL(-1) and their limits of quantification were established to be 25 ng mL(-1). The overall precision did not exceed 13.2% and the accuracy was within ±11.1%. Several drugs potentially co-administered with opicapone were tested and they did not interfere at the retention times of the analytes (opicapone and BIA 9-1079) and internal standard. The method was then successfully applied for quantifying opicapone and its active metabolite (BIA 9-1079) in plasma samples obtained from a healthy subject enrolled in a clinical trial. PMID:23476919

Gonçalves, Daniela; Alves, Gilberto; Fortuna, Ana; Soares-da-Silva, Patrício; Falcão, Amílcar

2013-04-21

70

An HPLC-DAD method for the simultaneous quantification of opicapone (BIA 9-1067) and its active metabolite in human plasma.  

UK PubMed Central (United Kingdom)

Opicapone (BIA 9-1067) is a novel catechol-O-methyltransferase inhibitor presently under clinical development as an adjuvant in the pharmacotherapy of Parkinson's disease. This report describes the development and validation of a bioanalytical assay for the simultaneous quantification of opicapone and its active metabolite (BIA 9-1079) in human plasma. The method herein reported is based on high-performance liquid chromatography coupled with diode-array detection (HPLC-DAD) and the sample preparation consists of a plasma protein precipitation step followed by liquid-liquid extraction. Chromatographic separation of the analytes (opicapone and BIA 9-1079) and the internal standard (tamoxifen) was achieved in less than 10 min on a reversed-phase C18 column at 25 °C by applying a gradient elution program using a mobile phase composed of 0.05 M monosodium phosphate solution adjusted to pH 2.45 (A) and acetonitrile (B) pumped at 0.8 mL min(-1). Opicapone and the internal standard were monitored at 271 nm while BIA 9-1079 was assessed at 257 nm. Calibration curves of both analytes were linear (r(2) ? 0.997) in the concentration range of 25-3000 ng mL(-1) and their limits of quantification were established to be 25 ng mL(-1). The overall precision did not exceed 13.2% and the accuracy was within ±11.1%. Several drugs potentially co-administered with opicapone were tested and they did not interfere at the retention times of the analytes (opicapone and BIA 9-1079) and internal standard. The method was then successfully applied for quantifying opicapone and its active metabolite (BIA 9-1079) in plasma samples obtained from a healthy subject enrolled in a clinical trial.

Gonçalves D; Alves G; Fortuna A; Soares-da-Silva P; Falcão A

2013-04-01

71

Ekspresja bia?ka zmutowanego genu p53 w rakach p?askonab?onkowych rozwijaj?cych si? w oparzonych prze?ykach  

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Full Text Available Wst?p: Rak p?askonab?onkowy prze?yku rozwija si? 22-krotnie cz??ciej w oparzonym prze?yku. Mutacja genu supresorowego p53 z nast?pow? akumulacj? patologicznego bia?ka jest w nowotworach najcz??ciej spotykan? patologi? dotycz?c? pojedynczego genu. Jest mo?liwe, ?e ró?ne czynniki mutagenne powoduj? ró?n? ilo?? mutacji w zakresie genu 53 i ró?nice w ekspresji bia?ka mutanta p53 w rakach rozwijaj?cych si? w prze?ykach oparzonych i nie oparzonych.Cel pracy: Autorzy porównali ekspresj? patologicznego bia?ka p53 w rakach p?askonab?onkowych prze?yku, rozwijaj?cych si? w prze?ykach oparzonych oraz w prze?ykach bez poprzedzaj?cych zmian patologicznych. Materia? i metody: Badania immunohistochemiczne akumulacji patologicznego bia?ka p53 z zastosowaniem techniki ABC przeprowadzono na skrawkach pochodz?cych od 7 chorych z rakiem p?askonab?onkowym rozwijaj?cym si? w oparzonym prze?yku. Grup? kontroln? stanowi?o 21 pacjentów z p?askonab?onkowym rakiem rozwijaj?cym si? w prze?yku bez wcze?niejszych zmian anatomicznych.Wyniki: W raku p?askonab?onkowym rozwijaj?cym si? w prze?yku oparzonym stwierdzono w 4 spo?ród 7 przypadków raka ?rednio zró?nicowanego, a w 3 przypadkach raka wysoko dojrza?ego. Wysok? ekspresj? patologicznego bia?ka p53 stwierdzono w 9 na 13 przypadków ?rednio zró?nicowanego raka w prze?yku nie oparzonym i we wszystkich 4 przypadkach raka w prze?ykach zbliznowacia?ych po oparzeniu. W wysoko dojrza?ym raku prze?yku ujawniono s?ab? b?d? ?redni? ekspresj? p53 w 3 spo?ród 5 przypadków raka w prze?ykach grupy kontrolnej oraz w jednym z 3 przypadków raka w prze?yku oparzonym. W badaniu immunohistochemicznym ujawniono umiarkowan? ekspresj? bia?ka p53 w jednym z 3 przypadków raka p?askonab?onkowego o niskim stopniu zró?nicowania rozwijaj?cego si? w nie oparzonym prze?yku. Wnioski: Akumulacja bia?ka mutanta genu supresorowego p53 wyst?puje w podobnym nat??eniu w rakach p?askonab?onkowych rozwijaj?cych si? w prze?ykach bliznowato zw??onych po oparzeniu i bez tej patologii. Najwy?szy stopie? ekspresji patologicznego bia?ka p53 stwierdzono w obu badanych grupach w rakach o ?rednim stopniu zró?nicowania.

Jerzy Rabczy?ski; Krzysztof Grabowski; Agata Kochman; Jerzy B?aszczuk

1998-01-01

72

PHYSICAL ACTIVITY AND LEISURE TIME AMONG 13-15-YEAR-OLD TEENAGERS LIVING IN BIA?A PODLASKA  

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Full Text Available The aim of the research was to get information about physical activity and forms of spending leisure time by teenagers between 13 and 15 years old, who live in Bia?a Podlaska. The research included 229 pupils from three Grammar Schools (115 girls and 114 boys). The range of respondents’ age is from 13 to 15 years old. The research tool was anonymous questionnaire consisting of questions concerning healthy lifestyle, physical activity and forms of spending leisure time. In total, the questionnaire consisted of 17 both open and close questions. On the basis of the questionnaire, it was proved that pupils’ knowledge on physical education and health is low (37-47% of correct answers). Young people more and more often choose passive forms of activity. Boys much more often take up active forms of exercise than girls. Teenagers devote most time to physical activity, the development of interests and taking care of one’s own appearance.

Grad Rafa?

2013-01-01

73

Molecular Dynamics of Spin Crossover: the (P,T) phase diagram of [Fe(PM-BIA)2(NCS)2  

CERN Document Server

The spin crossover properties and the domains of existence of the different phases for the [Fe(PM-BIA)2(NCS)2] complex are obtained from combining DFT and classical molecular dynamics (MD). The potential energy surfaces expressed in the Morse form for Fe-N interactions are deduced from molecular DFT calculations and they allow producing Infra Red and Raman frequencies. These Fe-N potentials inserted in a classical force field lead from MD calculations to the relative energies of the high spin and low spin configurations of the orthorhombic structure. The MD investigations have also allowed assessing the experimental (P, T) phase diagram by showing the monoclinic polymorph in its two spin- states, and generating two triple points.

Marbeuf, A; Matar, S F; Kabalan, L; Létard, J F; Guionneau, P

2013-01-01

74

Coprological study on helminth fauna in Eurasian lynx (Lynx lynx) from the Bia?owieza Primeval Forest in eastern Poland.  

Science.gov (United States)

One hundred fecal samples were collected during research on Eurasian lynx ecology and food habits in the Polish part of the Bia?owieza Primeval Forest (BPF) from 2001 to 2006. Seventy-three percent of samples contained eggs or larvae of helminths. A total of 10 species of helminths was identified, including 3 Cestoda (Diphyllobothrium latum, Spirometra janickii, and unidentified species of Taeniidae), 1 Trematoda (Alaria alata), and 6 Nematoda (Aelurostrongylus abstrusus, Ancylostoma tubaeforme, Eucoleus aerophilus, Metastrongylus sp., Nematodirus sp., and Toxocara cati). Alaria alata has not been reported previously in lynx. A statistical comparison of the 2 techniques used to isolate eggs, i.e., flotation and sedimentation, indicates that sedimentation was more effective. PMID:18576790

Szczesna, J; Popio?ek, M; Schmidt, K; Kowalczyk, R

2008-08-01

75

Porównanie przydatno?ci diagnostycznej prokalcytoniny i bia?ka C-reaktywnego w biegunkach o ró?nej etiologii  

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Full Text Available Wprowadzenie: Prokalcytonina (PCT) i bia?ko C-reaktywne (CRP) s? parametrami ostrej fazy o odmiennych cechach klinicznych. Cel pracy: Celem pracy by?o porównanie przydatno?ci diagnostycznej PCT i CRP u dzieci z biegunk? i gor?czk?. Materia? i metodyka: Badaniami obj?to 108 dzieci, które zakwalifikowano do jednej z 4 grup: A - biegunka b?d?ca jednym z objawów uogólnionego zaka?enia bakteryjnego (posocznicy/zapalenia opon mózgowo-rdzeniowych) (n=35); B - biegunka bakteryjna (n=28); C - biegunka rotawirusowa (n=35); D - nieswoiste zapalenie jelit (IBD) (n=10). Dla porównania przedstawiono tak?e wyniki bada? 30 zdrowych dzieci - grupa kontrolna. St??enie PCT oraz CRP oznaczono w surowicy krwi w chwili przyj?cia dzieci do szpitala. Wyniki: Najwy?sze st??enia PCT (19,1 ±3,4 ng/ml) i CRP(11,7±1,6 mg/dl) odnotowano w grupie A. W grupie B st??enie PCT przekracza?o 0,5 ng/ml u 15 dzieci, a poziom CRP by? wy?szy ni? 0,5 mg/dl w 21 przypadkach. Zaledwie u dwójki dzieci z grupy C i u dwojga z grupy D poziom PCT nieznacznie przekracza? górn? granic? normy. CRP by?o podwy?szone u 16 dzieci z grupy C i 8 z grupy D. Wniosek: PCT jest bardziej specyficznym markerem zaka?e? bakteryjnych ni? CRP.

Bartosz Korczowski; Waldemar Szybist; Wrzes?aw Roma?czuk; Jerzy Sieklucki; Józef Rusin

2002-01-01

76

Bia?ko kationowe eozynofilów (ECP) jako marker nadwra?liwo?ci oskrzeli u dzieci do lat 4  

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Full Text Available Pomiary st??enia ECP w surowicy i innych p?ynach ustrojowych wydaj? si? racjonalnym sposobem rozpoznawania alergicznych reakcji zapalnych i kontrolowania ich aktywno?ci oraz oceny stosowania odpowiedniego leczenia przeciwzapalnego. Celem niniejszej pracy by?a ocena przydatno?ci oznaczania kationowego bia?ka eozynofilów (ECP) jako markera zapalenia i nadwra?liwo?ci oskrzeli u niemowl?t i ma?ych dzieci ztzw. obturacyjnym zapaleniem oskrzeli. Badania obj??y 49 niemowl?t i ma?ych dzieci z pierwszym lub kolejnym incydentem obturacji oskrzeli. Oznaczono st??enie ECP, ca?kowity poziom IgE i IgE swoistych oraz eozynofili? bezwzgl?dn? we krwi obwodowej. Przeprowadzone badania wykaza?y, ?e warto?ci ECP, niezale?nie od obecno?ci klinicznych i laboratoryjnych wyk?adników atopii, nie koreluj? z ostr? faz? choroby. D?ugotrwa?e utrzymywanie si? podwy?szonych warto?ci ECP w stosunku do wyj?ciowych u 28 dzieci (57,1 %) mo?e wskazywa? na przetrwa?? w okresie bezo-bjawowym nadwra?liwo?? oskrzeli i by? wyk?adnikiem pomocnym w kwalifikowaniu dzieci do grupy nadzoru specjalistycznego.

Krystyna W?sowska-Królikowska; Jaros?aw Dynowski; Monika Tomaszewska; Ewa Kowalska

2001-01-01

77

Fagocytoza blastopor Candida albicans i lateksu przez granulocyty krwi obwodowej chorych na ostr? bia?aczk? (AL)  

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Full Text Available Podj?to badanie fagocytozy Candida albicans i lateksu przez granulocyty chorych na ostr? bia?aczk? (AL) przed leczeniem (AL/b.t) i w ca?kowitej remisji (AL/CR). Przebadano 32 chorych na AL/b.t. i 21 osób w CR oraz 21 osób zdrowych (grupa kontrolna - Control). W badanych grupach oznaczono odsetek fagocytuj?cych granulocytów (PG) i wska?nik fagocytozy (Pl). Jako czynnika opsonizuj?cego u?yto autologicznej surowicy. ?rednia PG Candida albicans (33,1%±23,6) i ?rednia Pl (1,74±0,79) AL/b.t. by?y istotnie statystycznie ni?sze w porównaniu ze ?rednimi AL/CR (odp. 75,1%±10,4, 2,65±0,54). ?rednia PG lateksu (53,9%±21,3) i ?rednia Pl (9,43±4,15) grupy AL/b.t. by?a statystycznie istotnie ni?sza w porównaniu ze ?rednimi grupy w CR (odp. 87%±9, 18,58±4,12). ?rednie grupy kontrolnej - PG lateks (94,2%±3,52) i ?rednia Pl (19,34+1,98) by?y istotnie statystycznie wy?sze w porównaniu z AL/CR. Badania wskazuj?, ?e upo?ledzenie aktywno?ci fagocytarnej u chorych na AL, dodatkowo do granulocytopenii wynikaj?cej z choroby, jest jednym z czynników odpowiedzialnych za wysokie wyst?powanie grzybiczych i bakteryjnych infekcji u tych chorych.

Jadwiga Nowicka

2003-01-01

78

The potential health hazard due to elevated radioactivity in old uranium mines in Dolina Bia?ego, Tatra Mountains, Poland.  

Science.gov (United States)

Natural radioactivity is one of the essential components of the environment. Unlike the Sudety mountains area in Poland, the Tatra Mountains were not the subject of wide survey as regards the levels of natural radioactivity. Especially, the concentrations of radon (natural radioactive gas) have not been investigated there in terms of their possible negative health impact. Within the frame of bilateral cooperation between the Institute of Nuclear Physics in Kraków, Poland, and the Jožef Stefan Institute in Ljubljana, Slovenia, the measurements of natural radioactive elements in old uranium mines in the Tatra National Park were performed in June 2010. The investigated sites were located in Dolina Bia?ego (The Valley of the White). One of the mines is situated near the tourist path. The paper presents the results of complex measurements of natural radioactivity in both uranium drifts. The concentration of radon gas inside the mining drifts exceeded 28,000 Bq m(-3). Also, very high gamma dose rates were observed (up to 5600 nSv h(-1)). The maximum concentrations of natural radioactive elements (potassium (40)K, radium (226)Ra, thorium (232)Th) in rock samples amounted to 535, 2137, and 18 Bq kg(-1), respectively. The effective dose rates due to radon and thoron inhalation have been assessed as 0.013 mSv h(-1) (for the lowest concentration) and 0.121 mSv h(-1) (for the highest concentration). PMID:23639059

Kozak, Krzysztof; Mazur, Jadwiga; Vaupoti?, Janja; Grz?dziel, Dominik; Kobal, Ivan; Omran, Khaled M H

2013-05-03

79

Analiza zaka?e? grzybiczych u chorych na ostre bia?aczki (AL). Cz??? I. Charakterystyka materia?u chorych i metody bada?. Wyniki bada? hematologicznych i mikologicznych  

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Full Text Available Wprowadzenie: Zaka?enia stanowi? g?ówn? przyczyn? niepowodze? leczenia w ostrych bia?aczkach. Wzrasta znaczenie zaka?e? grzybiczych w tych chorobach. Cel pracy: Ustalenie, jakie zaka?enia wyst?puj? najcz??ciej przy rozpoznaniu ostrej bia?aczki, jaki jest udzia? zmian grzybiczych, jak narasta kolonizacja uk?adu oddechowego i moczowego przez patogeny grzybicze, jakie grzyby hodowane s? z krwi chorych oraz które z nich wykazuj? immunogenny wp?yw na chorych (badanie obecno?ci w surowicy dodatnich reakcji immunoprecypitacji metod? wolnej dyfuzji wg Ouchterlony). Materia? i metody: Materia? badany stanowi?o 140 chorych na ostr? bia?aczk?, podzielonych wg FAB (M0-11, M1-22, M2-25, M3-3, M4-22, M5-8, L1-20, L2-22, L3-1) w wieku 16-70 lat, 70 kobiet i 70 m??czyzn. W czasie indukcji remisji stosowano profilaktyk? doustnymi lekami przeciwgrzybiczymi. Metody analizy obejmowa?y anamnez?, badanie fizyczne, ocen? stanu wg Karnofsky'ego, badania hematologiczne morfologii krwi i szpiku, badania mitologiczne materia?u od chorych na pocz?tku i w czasie trwania choroby. Wyniki: Przy rozpoznaniu ostrej bia?aczki do najcz??ciej wyst?puj?cych objawów nale?a?a infekcja górnych dróg oddechowych. Zaka?enia grzybicze na pocz?tku choroby stwierdzono u 12% chorych - by?a to grzybica ?luzówek jamy ustnej i gard?a u 13 osób i zmiany skórne o charakterze pityriasis versicolor u 4 osób. Analiza bada? hematologicznych wykaza?a obecno?? agranulocytozy u 35% chorych przed leczeniem cytostatycznym. W szpiku wysoki by? odsetek komórek blastycznych (w AML 76%, w ALL 82%), natomiast niski - odsetek dojrzewaj?cych i dojrza?ych form uk?adu granulocy-towego (w AML 4,67%, w ALL 3,51%). Analiza bada? mikologicznych w trakcie choroby wskazywa?a na narastanie kolonizacji uk?adu oddechowego (zw?aszcza przez Candida albicans) u 45% chorych przy rozpoznaniu do 80% w przebiegu choroby. Z krwi najcz??ciej hodowano Penicillium. Metod? wolnej dyfuzji wg Ouchterlony u chorych wykazano istotnie statystycznie cz?stsze reakcje z antygenami ró?nego rodzaju Aspergillus w porównaniu z najcz??ciej hodowanym z materia?u od chorych Candida albicans. Reakcje te wyst?powa?y istotnie statystycznie cz??ciej w porównaniu z grup? kontroln? osób zdrowych. Wnioski: Pierwsze objawy ostrej bia?aczki to zazwyczaj stany zapalne, w zakresie górnych dróg oddechowych u po?owy chorych. Najcz?stszym patoge-nem by? Candida albicans. Kolonizacja uk?adu oddechowego wzros?a w czasie trwania choroby. Wykazano znacz?cy wp?yw immunogenny grzybów z rodzaju Aspergillus na surowic? u chorych na ostr? bia?aczk?.

Jadwiga Nowicka

2004-01-01

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Occurrence of fungi and fungus-like organisms in the Horodnianka River in the vicinity of Bia?ystok, Poland.  

Science.gov (United States)

Studies of fungi and fungus- like organisms in the northeastern Poland have mainly concentrated on running waters in the vicinity of Bia?ystok, including the Horodnianka River. The main objective was to investigate biodiversity of fungi and fungus-like organisms which take part in decomposition of organic matter commonly found in inland waters. To obtain a complete picture of species composition of fungi and fungus-like organisms in running waters we decided to explore representative sites of the Horodnianka River such as Olmonty, Hryniewicze and Horodniany with close localization of landfill. Fungal species were isolated using baiting technique. Baits of onion skin (Alium cepa), hemp-seeds (Cannabis sativa), impregnated cellophane and snake skin (Natrix natrix) were applied to isolate fungi from water of the Horodnianka River. The fungal community consists of 26 species, 10 species of fungi belonging to class Chytridiomycetes (3), anamorphic fungi (6), and Zygomycetes (1). 16 species belong to fungus-like organisms from class Oomycetes. Most of the recognized species have already been found in other running waters. From all the examined habitats the fungi belonging to 26 species of 18 genera Achlya, Alternaria, Aphanomyces, Aspergillus, Catenophlyctis, Dictyuchus, Fusarium, Karlingia, Lagenidium, Leptomitus, Olpidiopsis, Penicillium, Phlyctochytrium, Pythium, Saprolegnia, Scoliognia, Thraustotheca and Zoophagus were obtained. Certain fungal species like Aphanomyces laevis, Fusarium aqueductum, F. moniliforme, F. oxysporum, Leptomitus lacteus, Saprolegnia feax and S. parasitica were found at all the study sites. Among fungi potentially pathogenic and allergogenic for humans the genera Alternaria, Aspergillus, Fusarium, Lagenidium and Penicillium have already been described. However, the species Lagenidium giganteum and Achlya androgyna are new in the fungal biota of Poland. The greatest number of fungal species occurred in Olmonty (24), the smallest in Horodniany (13). Presence of fungi such as Leptomitus lacteus, Fusarium aqueductum in the water of the Horodnianka River offers the possibility of using them as indicators of water quality. PMID:22165737

Kiziewicz, Bozena; Zdrojkowska, Ewa; Gajo, Bernadetta; Godlewska, Anna; Muszy?ska, Elzbieta; Mazalska, Bozenna

2011-01-01

 
 
 
 
81

Rola bia?ka AS160/TBC1D4 w transporcie glukozy do wn?trza miocytów[i][/i  

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Full Text Available Mi??nie szkieletowe to jedne z najwa?niejszych tkanek uczestnicz?cych w utrzymaniu homeostazy glukozy ca?ego organizmu. Glukoza przenika do komórek mi??niowych na zasadzie dyfuzji u?atwionej, zachodz?cej z udzia?em transporterów glukozy (GLUT). Stymulacja insulinowego (zwi?zanego z aktywacj? 3-kinazy fosfatydyloinozytolu – PI3K) b?d? te? niezale?nego od insuliny (zwi?zanego z aktywacj? kinazy zale?nej od AMP – AMPK) szlaku przeka?nictwa sygna?u uruchamia kaskad? reakcji prowadz?c? do translokacji GLUT-4 do b?ony komórkowej, a w konsekwencji do wzrostu wychwytu glukozy w miocytach. W prowadzonych ostatnio badaniach wykazano, ?e bezpo?rednio w proces translokacji GLUT-4 jest zaanga?owane bia?ko sygna?owe okre?lane jako AS160 – substrat Akt o masie cz?steczkowej 160 kDa. Bia?ko to prawdopodobnie jest ogniwem ??cz?cym szlak insulinowy ze szlakiem zale?nym od aktywacji kinazy AMPK. Badania potwierdzaj?, i? fosforylacja AS160 ulega wzmo?eniu zarówno pod wp?ywem stymulacji insulin?, jak te? podczas wysi?ku fizycznego, co wskazuje na ich addytywn? zale?no??. W mi??niach szkieletowych osób z oporno?ci? na insulin? i/lub cukrzyc? typu 2 dochodzi do znacznego obni?enia zale?nej od insuliny fosforylacji bia?ka AS160 i spadku translokacji do b?ony GLUT-4. St?d te? zmniejszony poziom insulinozale?nej fosforylacji AS160 mo?e odgrywa? istotn? rol? w oporno?ci na insulin?[i] in vivo[/i].

Agnieszka Mik?osz; Karolina Konstantynowicz; Tomasz Stepek; Adrian Chabowski

2011-01-01

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Ekspresja kinazy Jak3 i aktywacja bia?ka Stat3 u chorych na reumatoidalne zapalenie stawów i spondyloartropatie zapalne  

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Full Text Available Wst?p: Uk?ad przeka?nikowy Jak/Stat (kinaza tyrozynowaJanus/sygna? transdukcji i aktywacji transkrypcji) jest wykorzystywanyprzez wiele cytokin, czynników wzrostu i hormonów reguluj?cychmechanizmy transkrypcji genów oraz aktywacji, proliferacji,ró?nicowania i apoptozy komórek. Wyniki dotychczasowych bada?wskazuj?, ?e kinaza Jak3 odgrywa istotn? rol? w patogeneziereumatoidalnego zapalenia stawów (RZS). Cel pracy: Ocena ekspresji Jak3 oraz aktywacji Stat3 w leukocytachkrwi obwodowej (LKO) i komórkach p?ynu stawowego (KPS)u chorych na RZS i spondyloartropatie zapalne (SpaZ) oraz analizazwi?zku badanych parametrów ze wska?nikami aktywno?ci chorobyu?ywanymi w praktyce klinicznej. Ponadto analizie poddanozale?no?ci mi?dzy ekspresj? Jak3 a aktywacj? Stat3. Materia? i metody: Do badania zakwalifikowano 19 chorych na RZSoraz 22 chorych na SpaZ (zesztywniaj?ce zapalenie stawów, ?uszczycowezapalenie stawów, spondyloartropatia niezró?nico wana).Grup? kontroln? stanowi?y 23 zdrowe osoby. W badanych grupachw LKO metod? immunocytochemiczn? oznaczono ekspresj? kinazyJak3 i aktywacj? bia?ka Stat3. T? sam? metod? oznaczono ekspresj?Jak3 i aktywacj? Stat3 u 11 chorych na RZS i u 12 chorych na SpaZw KPS. U chorych zosta?y oznaczone warto ?ci parametrów stanuzapalnego oraz wska?ników aktywno?ci choroby DAS28 i BASDAI.Wykonano rentgenogramy stawów zaj?tych procesem chorobowym. Wyniki: Ekspresja Jak3 oraz aktywacja Stat3 by?y znacz?co wy?szeu chorych na RZS i SpaZ w porównaniu z grup? kontroln?. War to -?ci te by?y wy?sze w KPS ni? w LKO. U chorych na RZS zaobserwowanododatni? korelacj? mi?dzy aktywno?ci? Stat3 w KPSa warto?ci? CRP. Nie wykazano korelacji mi?dzy ekspresj? Jak3a aktywacj? Stat3. Wnioski: Funkcja Jak3 i Stat3 jest zwi?zana z procesem immunolo -gicznym w przebiegu RZS i SpaZ. Wydaje si?, ?e zablokowanie ichfunkcji mo?e stanowi? cel terapeutyczny w obydwu grupach chorych.

Joanna Krywejko; Dagmara Pokorna-Ka?wak; Anna Czarny; Ewa Zaczy?ska; Magdalena Szmyrka-Kaczmarek; Piotr Wiland; Andrzej Steciwko

2010-01-01

83

Równoczesna ocena st??enia eozynofilowego bia?ka kationowego i eozynofili krwi obwodowej w czasie dodatnich prób prowokacji pokarmowych  

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Full Text Available Wprowadzenie: U dzieci z IgE-zale?n? alergi? pokarmow? w czasie dodatnich DBPCFC w miejscu reakcji alergicznej dochodzi do akumulacji i aktywacji eozynofilów. Cel pracy: Sprawdzenie, czy zjawiska te mo?na ?ledzi? poprzez pomiar w surowicy krwi eozynofilii krwi obwodowej, EOS (marker wzrostu syntezy eozynofilów) i eozynofilowego bia?ka kationowego, ECP (marker aktywacji eozynofilów). Materia? i metodyka: Oznaczenia wykonano w czasie 18 DBPCFC (pszenica -16, ?yto - 1, kukurydza - 1), które przeprowadzono u 18 dzieci z IgE-zale?n? alergi? na ziarna zbó? (5 dziewczynek, 13 ch?opców w wieku 2,5-14 lat, ?rednio 5 lat). Reakcje niepo??dane wyst?puj?ce w DBPCFC obejmowa?y objawy z przewodu pokarmowego i skóry; wjednym przypadku wstrz?s anafilaktyczny. St??enie ECP i wielko?? EOS oznaczano w czasie 0 h, 2 h, 24 h, 48 h, 14 dni. Rozpoznanie IgE-zale?nej alergii pokarmowej postawiono na podstawie dodatniej natychmiastowej DBPCFC u dzieci z dodatnimi markerami atopii (sIgE>0,7kU/L oznaczane w systemie CAP, Pharmacia). St??enie ECP oznaczano metod? FEIA (Pharmacia), EOS metodami rutynowymi. Istotno?? ró?nic pomi?dzy badanymi parametrami oceniano testem Ko?mogorova-Smirnova. Wyniki: Przed prowokacj? mediana st??enia ECP wynosi?a 7,3 ug/L (2,3-20,9 ug/L), a liczba EOS: 338,5x106/L (87,0-643,0x106/L). W 2 h po dodatniej DBPCFC liczba EOS by?a istotnie ni?sza (p<0,001), a ECP istotnie wy?sza (p<0,001) w stosunku do warto?ci sprzed prowokacji. Po 24 h od prowokacji liczba EOS by?a wy?sza od warto?ci sprzed prowokacji (p<0,001); nie zmienia?a si? przez 14 dni. W 24 h godzinie od prowokacji st??enie ECP by?o istotnie ni?sze ni? w 2 h (p<0,001), ale istotnie wy?sze ni? przed prowokacj? (p<0,001). Wniosek: Pomiar w surowicy krwi st??enia ECP i liczby EOS jest przydatny w ocenie wzrostu syntezy i aktywacji eozynofilów w czasie dodatniej DBPCFC.

Gra?yna Czaja-Bulsa; Gra?yna Ma?ecka

2002-01-01

84

Eslicarbazepine acetate (BIA 2-093) : relative bioavailability and bioequivalence of 50 mg/mL oral suspension and 200mg and 800mg tablet formulations.  

UK PubMed Central (United Kingdom)

PURPOSE: To investigate the bioavailability and bioequivalence of three different formulations of eslicarbazepine acetate (BIA 2-093): 50 mg/mL oral suspension (test 1), 200mg tablets (test 2) and 800mg tablets (reference). DESIGN, SUBJECTS AND METHODS: Single-centre, open-label, randomised, three-way crossover study in 18 healthy subjects. The study consisted of three consecutive periods separated by a washout period of 7 days or more. Each subject received a single dose of eslicarbazepine acetate 800mg on three different occasions: 16mL of oral 50 mg/mL suspension, four 200mg tablets or one 800mg tablet. RESULTS: Eslicarbazepine acetate was rapidly and extensively metabolised to BIA 2-005. Maximum BIA 2-005 plasma concentrations (Cmax) and area under the plasma concentration-time curve from time 0 to infinity (AUCinfinity) were, respectively (arithmetic mean +/- SD), 18.0 +/- 4.6 microg/mL and 325.7 +/- 64.9 microg x h/mL for test 1, 16.0 +/- 4.0 microg/mL and 304.2 +/- 66.0 microg x h/mL for test 2, and 17.0 +/- 4.1 microg/mL and 301.1 +/- 60.0 microg x h/mL for the reference formulation. Point estimate (PE) and 90% confidence intervals (CIs) for AUCinfinity test 1/reference geometric mean ratio were 1.09 and 1.01, 1.15; for Cmax ratio, PE and 90% CI were 1.07 and 0.97, 1.15. When test 2 and the reference formulations were compared, the PE and 90% CI were 0.99 and 0.94, 1.07 for the AUCinfinity ratio, and 0.94 and 0.86, 1.02 for the Cmax ratio. Bioequivalence of test versus reference formulations is thus accepted for both AUCinfinity and Cmax because the 90% CIs lie within the acceptance range of 0.80-1.25. CONCLUSION: The pharmacokinetic profiles of eslicarbazepine acetate oral 50 mg/mL suspension, 200mg tablet and 800mg tablet formulations were essentially similar, and the formulations can be considered bioequivalent.

Fontes-Ribeiro C; Nunes T; Falcão A; Neta C; Lima R; Tavares S; Almeida L; Macedo T; Soares-da-Silva P

2005-01-01

85

Analiza zaka?e? grzybiczych u chorych na ostre bia?aczki (AL). Cz??? II. Lokalizacja narz?dowa zmian zapalnych z uwzgl?dnieniem zmian grzybiczych. Cz?sto?? infekcji grzybiczych w zale?no?ci od rodzaju ostrej bia?aczki wg klasyfikacji FAB. Przyczyny zgonu  

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Full Text Available Wprowadzenie: Grzybica wyst?puje ?rednio u 25% zmar?ych na ostr? bia?aczk?. Cel pracy: Celem pracy by?o ustalenie: 1) jaka jest lokalizacja narz?dowa zmian zapalnych, w tym grzybiczych, 2) która z grup ostrej bia?aczki wg FAB jest najbardziej podatna na zaka?enie grzybicze oraz 3) jaki jest udzia? zaka?e? grzybiczych w przyczynie zgonu chorych. Materia? i metody: Materia? badany stanowi?o 140 chorych na ostr? bia?aczk? (70 kobiet i 70 m??czyzn) w wieku 16-70 lat, podzielonych wg FAB (M0-11, M1-22, M2-25, M3-3, M4-22, M5-8, L1-20, L2-22, L3-1). U chorych w czasie indukcji remisji stosowano profilaktycznie doustne leki przeciw-grzybicze. W czasie trwania choroby analizowano lokalizacj? i etiologi? stanu zapalnego w oparciu o badania mikologiczne i bakteriologiczne. U 123 zmar?ych przyczyn? zgonu ustalono na podstawie objawów klinicznych przed zgonem i na podstawie badania patomorfologicznego. Wyniki: Na podstawie obserwacji klinicznej oraz bada? mikologicznych i bakteriologicznych stwierdzono, i? w trakcie choroby zmiany zapalne najcz??ciej dotyczy?y uk?adu pokarmowego, uk?adu oddechowego i moczowego. Zaobserwowano, ?e na pocz?tku choroby przewa?a?y zaka?enia górnych dróg oddechowych, a w przebiegu choroby wzros?a liczba zapale? p?uc. Infekcje w zakresie uk?adu moczowego cechowa?y si? brakiem znamiennej dla osób zdrowych leukocyturii. Na podstawie wyst?powania zaka?e? grzybiczych nie stwierdzono, by grupy ró?ni?y si? liczb? infekcji grzybiczych. Dopiero przy u?yciu metody Poissona, ujawniono, i? najwi?ksz? cz?sto?? wyst?powania infekcji grzybiczych wykazuje grupa M5, M1 i M4 wg FAB. Zgon u 2/3 osób dotyczy? chorych w agranulocytozie. U 12% zmar?ych wykazano udzia? infekcji grzybiczej (10 osób z kandydoz? i 1 z aspergiloz?). Wnioski: Lokalizacja zmian grzybiczych najcz??ciej dotyczy?a uk?adu pokarmowego i oddechowego. Funguria mo?e by? wynikiem zmian zapalnych w uk?adzie moczowym lub zmian zapalnych w innych narz?dach i stanowi form? eliminacji grzybów z ustroju, zw?aszcza w agranulocytozie; nie przebiega z leukocyturi?. Cz?sto?? wyst?powania infekcji grzybiczych jest najwi?ksza w bia?aczkach M5.

Jadwiga Nowicka

2004-01-01

86

A temporal-omic study of Propionibacterium freudenreichii CIRM-BIA1 adaptation strategies in conditions mimicking cheese ripening in the cold.  

UK PubMed Central (United Kingdom)

Propionibacterium freudenreichii is used as a ripening culture in Swiss cheese manufacture. It grows when cheeses are ripened in a warm room (about 24°C). Cheeses with an acceptable eye formation level are transferred to a cold room (about 4°C), inducing a marked slowdown of propionic fermentation, but P. freudenreichii remains active in the cold. To investigate the P. freudenreichii strategies of adaptation and survival in the cold, we performed the first global gene expression profile for this species. The time-course transcriptomic response of P. freudenreichii CIRM-BIA1(T) strain was analyzed at five times of incubation, during growth at 30°C then for 9 days at 4°C, under conditions preventing nutrient starvation. Gene expression was also confirmed by RT-qPCR for 28 genes. In addition, proteomic experiments were carried out and the main metabolites were quantified. Microarray analysis revealed that 565 genes (25% of the protein-coding sequences of P. freudenreichii genome) were differentially expressed during transition from 30°C to 4°C (P<0.05 and |fold change|>1). At 4°C, a general slowing down was observed for genes implicated in the cell machinery. On the contrary, P. freudenreichii CIRM-BIA1(T) strain over-expressed genes involved in lactate, alanine and serine conversion to pyruvate, in gluconeogenesis, and in glycogen synthesis. Interestingly, the expression of different genes involved in the formation of important cheese flavor compounds, remained unchanged at 4°C. This could explain the contribution of P. freudenreichii to cheese ripening even in the cold. In conclusion, P. freudenreichii remains metabolically active at 4°C and induces pathways to maintain its long-term survival.

Dalmasso M; Aubert J; Briard-Bion V; Chuat V; Deutsch SM; Even S; Falentin H; Jan G; Jardin J; Maillard MB; Parayre S; Piot M; Tanskanen J; Thierry A

2012-01-01

87

Participation and Protected Areas Governance: the Impact of Changing Influence of Local Authorities on the Conservation of the Bia?owie?a Primeval Forest, Poland  

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Full Text Available According to the new conservation paradigm, protected areas should contribute to the socioeconomic development of host communities, and the latter ought to be included in participatory decision making concerning these areas. However, the understanding of participation is ambiguous and there are at least three major approaches, which may have different impacts on the governance of protected areas. We examine the case of the Bia?owie?a Primeval Forest in order to trace the effectiveness of changing modes of participation as well as to discuss the limitations and problems of public participation. Between 1918 and 2010, the role of local authorities changed from no influence to limited control over decision making regarding designation and enlargement of the Bia?owie?a National Park (BNP). As a result of these changes, attempts to enlarge the BNP over the whole forest were undermined. The evidence shows that power relations and instrumental reasons constituted the main drivers of the changing participation pattern with deliberative rationale lacking. As a result, the conservation goals were only partially achieved. We argue that when interests are clearly conflicting and win–win solutions are difficult to reach, room for constructive participation may be limited. In these circumstances, public involvement may turn into yet another venue for a power play between actors with vested interests, without bringing gains in legitimacy or new policy options. This is especially the case for countries with a relatively short democratic record where the government lacks the consistency and capacity to steer the process over the longer term.

Krzysztof Niedzia?kowski; Jouni Paavola; Bogumi?a J?drzejewska

2012-01-01

88

Analiza ekspresji wewn?trzkomórkowych proapoptotycznych (Bax, Bak) i antyapoptotycznych (Bcl-2, Bcl-XL) bia?ek w tyreocytach u m?odocianych pacjentów ze schorzeniami immunologicznymi i nieimmunologicznymi gruczo?u tarczowego  

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Full Text Available Apoptoza to jedna z postaci programowanej ?mierci komórek, która jest zjawiskiem fizjologicznym, niezb?dnym do prawid?owego funkcjonowania ka?dego organizmu. Jest to proces aktywny, przebiegaj?cy z udzia?em metabolizmu komórkowego obejmuj?cego aktywacj? genów i syntez? bia?ek. Sygna? do apoptozy mo?e by? uruchomiony praktycznie w ka?dej komórce naszego organizmu. Zaburzenia regulacji apoptozy stanowi? istotne ogniwo patogenezy wielu chorób, w tym chorób autoimmunologicznych tarczycy. Celem pracy by?a ocena ekspresji bia?ek proapoptotycznych i antyapoptotycznych w tkance gruczo?u tarczowego u 12 pacjentów z chorob? Gravesa-Basedowa (GB), u 10 pacjentów z wolem guzkowym nietoksycznym (NTNG) oraz u 10 osób z wolem guzkowym toksycznym (TNG). Kryteria kwalifikacji pacjentów z chorob? GB: wole II°, obecno?? oftalmopatii, TRAb >5 U/L, dodatnie miana przeciwcia? anty-TPO i anty-TG oraz utrzymuj?ce si? ponad 2-3 miesi?ce od pocz?tku rozpoznania TSH ?0.45 µIU/mL. Oznaczenie ekspresji bia?ek apoptozy w komórkach p?cherzykowych tarczycy przeprowadzono w oparciu o metod? Western Blot. Analiz? uzupe?niono badaniem immunohistochemicznym przy u?yciu przeciwcia? monoklonalnych z wizualizacj? DAB-em i barwieniem hematoksylin? Mayera. Identyfikacja bia?ek antyapoptotycznych Bcl-2 i Bcl-XL wykaza?a ich znamienn? ekspresj? w komórkach tarczycy u pacjentów z chorob? GB (+++; ++) w porównaniu do ekspresji w grupie z NTNG (++/+; +) i TNG (++; +). Analiza ekspresji bia?ek proapoptotycznyh w badanych grupach wykaza?a przede wszystkim ich obecno?? w tkance tarczycy pacjentów z GB (Bak ++/+ ; Bax +), przy ?ladowej ekspresji Bax w NTNG (0/+) i TNG (0/+). Podsumowuj?c mo?na stwierdzi?, i? w schorzeniach tarczycy wieku rozwojowego dochodzi do zaburze? przebiegu apoptozy w komórkach p?cherzykowych tarczycy, doprowadzaj?cych do przewagi procesu proliferacji nad ?mierci? komórek, co w efekcie powoduje powi?kszenia gruczo?u tarczowego. Dodatkowo zmiany ekspresji bia?ek pro- i antyapoptotycznych w tyreocytach wskazuj? na udzia? apoptozy w patogenezie choroby Gravesa-Basedowa.

Artur Bossowski; Barbara Czarnocka; Krzysztof Bardadin; Miros?awa Urban; Marek Niedziela; Jacek Dadan

2007-01-01

89

Ekspresja bia?ek apoptozy FasL i CPP-3 jako czynnik predykcyjny odpowiedzi na leczenie interferonem alfa przewlek?ych zapale? w?troby typu B  

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Full Text Available Wprowadzenie: Apoptoza hepatocytów zaka?onych HBV (ang. hepatitis B virus) zarówno tych aktywnie replikuj?cych wirusy, jak i wydzielaj?cych jedynie cccDNA (ang. covalently closed circulate DNA), jest obecnie jedyn? potencjaln? drog? skutecznej eradykacji zaka?enia HBV. Cel pracy: Próba oceny przydatno?ci oznaczania stopnia nasilenia apoptozy komórek w?troby (wyra?onej ekspresj? bia?ek apoptotycznych Fas ligandu (FasL) i kaspazy 3 (CPP-3)) w rokowaniu odpowiedzi na terapi? interferonem alfa (IFN-alfa) u pacjentów z przewlek?ym wirusowym zapaleniem w?troby typu B (pwzw B). Materia? i metody: Analizie poddano 24 osoby rasy kaukaskiej, obojga p?ci (6 kobiet - 25% i 18 m??czyzn - 75%), o ?redniej wieku 36,7±14,9 lat, z rozpoznaniem pwzw B, których poddano terapii IFN-alfa. Bia?ka CPP-3 i FasL oceniono metodami immunohistochemicznymi oraz immunopatomorfologicznymi. Wyniki: Wyró?niono grup?: "a" - badania apoptozy wykonano przed rozpocz?ciem leczenia IFN-alfa, a nast?pnie wdro?ono terapi? - 9 pacjentów, oraz grup? „p" - badania apoptozy wykonano po zako?czeniu leczenia IFN-alfa - 15 pacjentów. U chorych z odpowiedzi? wirusologiczn? i biochemiczn? na leczenie (sustained virological response - SVR) stwierdzono 2 razy wy?sz? ekspresj? CPP-3 przed leczeniem ni? w grupie, która nie odpowiedzia?a na lecznie: Me (mediana) CPP-3 = 2 vs Me CPP-3 = 1; p?0,05. W grupie, która uzyska?a SVR, stwierdzono po leczeniu 3-4 razy wy?sz? ekspresj? Fas ligandu w hepatocytach i cholangiocytach (FasLH, K): D FasL (H) = 6 vs D FasL (H) = 2; D FasL (K) = 4 vs D FasL (K) = 1; p=0,042. Wnioski: Wyniki bada? w?asnych sugeruj?, ?e wyj?ciowy stopie? nasilenia apoptozy komórek w?trobowych mia? wp?yw na efektywno?? stosowanej standardowej terapii IFN-alfa u przewlekle zaka?onych HBV. Oznacza to, ?e im bardziej by?a nasilona apoptoza hepatocytów wyj?ciowo przed leczeniem, tym wi?ksza by?a szansa uzyskania trwa?ej odpowiedzi na leczenie immunomodulacyjne i przeciwwirusowe. Mo?na te? przyj??, ?e nasilenie apoptozy hepatocytów u pacjentów w przesz?o?ci poddanych terapii IFN-alfa, po?rednio mia?o zwi?zekz pozytywnym efektem terapeutycznym.

Sylwia Serafi?ska; Krzysztof Simon; Agnieszka Ha?o?

2008-01-01

90

Single-Dose Tolerability, Pharmacokinetics, and Pharmacodynamics of Etamicastat (BIA 5-453), a New Dopamine {beta}-Hydroxylase Inhibitor, in Healthy Subjects.  

UK PubMed Central (United Kingdom)

The safety, tolerability, pharmacokinetics, and pharmacodynamics of etamicastat (BIA 5-453), a novel dopamine ?-hydroxylase (D?H) inhibitor, were investigated in 10 sequential groups of 8 healthy male subjects under a double-blind, randomized, placebo-controlled design. In each group, 6 subjects received a single dose of etamicastat (2, 10, 20, 50, 100, 200, 400, 600, 900, or 1200 mg) and 2 subjects received placebo. Etamicastat was well tolerated at all dose levels tested. Maximum plasma etamicastat concentrations occurred at 1 to 3 hours postdose. Elimination was biphasic, characterized by a first short early elimination half-life followed by a longer elimination phase of 16 to 20 hours for etamicastat doses of 100 mg and above. A high interindividual variability of pharmacokinetic parameters of etamicastat and its acetylated metabolite was observed. Pharmacogenomic data showed that N-acetyltransferase type 2 (NAT2) phenotype (rapid or slow N-acetylating ability) was a major source of variability. In NAT2 poor acetylators, the area under the plasma concentration-time curve from time zero to the last sampling time at which concentrations were at or above the limit of quantification (AUC(0-t)) of etamicastat was twice that observed in rapid acetylators. Consistent with that finding, AUC(0-t) of the acetylated metabolite was markedly higher in NAT2 rapid acetylators compared with poor acetylators. Inhibition of D?H activity was observed, reaching statistical significance for etamicastat doses of 100 mg and above.

Rocha JF; Vaz-da-Silva M; Nunes T; Igreja B; Loureiro AI; Bonifácio MJ; Wright LC; Falcão A; Almeida L; Soares-da-Silva P

2011-02-01

91

Poikilodermia jako objaw choroby przeszczep przeciw gospodarzowi u pacjenta po przeszczepie szpiku kostnego z powodu przewlek?ej bia?aczki szpikowej - opis przypadku  

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Full Text Available Choroba przeszczep przeciw gospodarzowi jest jednym z cz?stszych powik?a? po przeszczepieniu narz?dów i szpiku kostnego oraz po transfuzji krwi i jej produktów zawieraj?cych immunokompetentne limfocyty. U podstaw choroby przeszczep przeciw gospodarzowi (GVHD) le?y proliferacja limfocytów z przeszczepianych tkanek, które atakuj? narz?dy gospodarza, najcz??ciej skór?. Wyró?niamy postaæ ostr? GVHD, w której objawy pojawiaj? si? po ok. 3 tygodniach po wykonaniu transplantacji oraz postaæ przewlek?? GVHD, w przebiegu której pierwsze symptomy obserwuje si? ponad 100 dni od zabiegu. Niespecyficzne i bardzo ró?norodne zmiany skórne, zarówno w ostrej, jak i w przewlek?ej postaci choroby mog? byæ znamiennym objawem choroby przeszczep przeciw gospodarzowi. Najbardziej charakterystyczne dla GVHD s?zmiany twardzinopodobne. Objawy sugeruj?ce GVHD mog? byæ te? sprowokowane przez niektóre leki. Podkre?la si? te? liczne podobie?stwa mi?dzy GVHD a liszajem p?askim. Praca przedstawia przypadek pacjenta z poikilodermia, która mo?e byæ jednym z objawów GVHD. Pierwsze zmiany na skórze pojawi?y si? ok. 3 tygodnie po przeszczepieniu szpiku z powodu przewlek?ej bia?aczki szpikowej i by?y jedynym objawem GVHD.

Anna Rosi?ska; Agnieszka Zawirska; Iwona Grzeszczak; Zygmunt Adamski

2007-01-01

92

Water Quality from Mangrove Forest: The King’s Royally Initiated Laem Phak Bia Environmental Research and Development Project, Phetchaburi Province, Thailand  

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Full Text Available The study was aimed to study water quality treated by mangrove forest. This study has been conducted at the mangrove forest site of the King’s Royally Initiated Laem Phak Bia Environmental Research and Development Project (the Royal LERD Project), Ban Laem District, Phetchaburi Province, Thailand. The study site, where Avicennia marina is dominant plant, is divided into in 3 areas; (A) the tideland area between constructed pond and mangrove forest, 200 meters from outlet (B) area of mangrove forest, distance 201 to 900 meters from outlet and (C) sea area, started from 901 meters from outlet. Six parameters were investigated; including temperature, pH, dissolved oxygen (DO), phosphate, nitrate, and ammonia. The results showed that water quality from mangrove forest met the effluent standards for coastal aquaculture (Ministry of Natural Resources and Environment, 2004). Mangrove forest can be able to improve water quality by increasing DO by 32.39%, while reducing phosphate, ammonia, and nitrate by 88.23%, 73.77%, and 64.28% respectively. It can be used as an additional natural system to increase the efficiency of man-made wastewater treatment system.

Orathai Jitthaisong; Pricha Dhanmanonda; Kasem Chunkao; Sakhan Teejuntuk

2012-01-01

93

Badania powietrza domów pomocy spo?ecznej w Bia?ymstoku i okolicy pod wzgl?dem wyst?powania grzybów w okresie lata i jesieni  

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Full Text Available Wst?p: W okresie ostatnich lat liczba zaka?e? grzybiczych u pacjentów hospitalizowanych uleg?a podwojeniu. Cel badania: Ocena wyst?powania grzybów dro?d?opodobnych i ple?ni w powietrzu w domu pomocy spo?ecznej w Bia?ymstoku i okolicy. Materia? i metody: Zanieczyszczenie powietrza (przed budynkiem, w korytarzach, salach chorych, pokojach socjalnych, kuchniach, ?azienkach, toaletach) oceniano przy u?yciu urz?dzenia SAS SUPER 100 (Pbi International). SAS stosowany by? przez NASA oraz na pok?adzie ameryka?sko-rosyjskiej stacji orbitalnej MIR. Posiada on mi?dzynarodowy, ustalony standard pobierania próbek powietrza. Flor? grzybicz? ze ?cian, pod?óg, ?ó?ek, r?k personelu i ubra? uzyskiwano przy u?yciu aplikatora Count-Tact applicator i p?ytki Count-Tact (BioMerieux). Wymazy pobierano ze skóry i przestrzeni mi?dzypalcowych r?k i stóp, paznokci i jamy ustnej. Grzyby hodowano na pod?o?u Sabourauda, a ich identyfikacj? przeprowadzano przy u?yciu standardowych procedur. Wyniki: Badania mikrobiologiczne powietrza oraz ?cian wykaza?y istotne ró?nice w wyst?powaniu flory grzybiczej w zale?no?ci od miejsca izolacji (korytarze, sale chorych, pokoje socjalne, kuchnie, ?azienki, toalety itd.) i pory roku (lato, jesie?). Znamienny wzrost izolacji grzybów z powietrza i ?cian w domach pomocy spo?ecznej stwierdzono jesieni?. Podobny wzrost izolacji grzybów wykazano u mieszka?ców jesieni?. Grzyby dro?d?opodobne izolowane od mieszka?ców domów pomocy spo?ecznej by?y wra?liwe na leki przeciwgrzybicze oraz wykazywa?y ma?? aktywno?? enzymatyczn?. Wnioski: Stwierdzano istotny wzrost izolacji grzybów z powietrza jesieni? w domach pomocy spo?ecznej. Konieczne s? dalsze badania powietrza w celu oceny ich wyst?powania w innych porach roku (wiosna, zima).

El?bieta Krajewska-Ku?ak; Cecylia ?ukaszuk; El?bieta Oksiejczuk; Agnieszka Gniadek; Anna B. Macura; Jolanta Lewko; Wiaczes?aw Niczyporuk; Wojciech Cie?lak; Agata Wojewodko

2002-01-01

94

Wp?yw probiotycznych szczepów Lactobacillus casei i paracasei na przebieg kliniczny wyprysku atopowego u dzieci z alergi? pokarmow? na bia?ka mleka krowiego  

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Full Text Available Wst?p: Probiotyki, tj. ?ywe bakterie niepatogenne, wykazuj? korzystny wp?yw na zdrowie gospodarza. Bakterie probiotyczne mog? wspomaga? leczenie chorób alergicznych oraz wp?ywa? na rozwój procesu alergicznego u osób z predyspozycj? genetyczn?. Cel pracy: Ocena wp?ywu nowych szczepów probiotycznych z gatunku Lactobacillus casei i paracasei na przebieg kliniczny wyprysku atopowego (WA) u dzieci z alergi? pokarmow? na bia?ka mleka krowiego. Materia? i metodyka: Badaniem przeprowadzonym w sposób randomizowany, podwójnie za?lepiony, ??cznie z grup? kontroln? obj?­to 60 dzieci z WA w wieku do 24 miesi?ca ?ycia. Dzieciom podawano doustnie mieszanin? 3 szczepów: Lactobacillus casei LOCK 0900, Lactobacillus casei LOCK 0908 i Lactobacillus paracasei LOCK 0919 przez okres 3 miesi?cy w dawce dziennej 109 komórek. Grupa kontrolna otrzyma?a no?nik bakterii, tj. hydrolizat kazeiny. Stan kliniczny dzieci oceniono w skali SCORAD (ang. Scoring Atopic Dermatitis) przed rozpocz?ciem kuracji, po zako?czeniu oraz po 5-ciu miesi?cach obserwacji. Wyniki: Tylko u dzieci z WA IgE-zale?nym podanie probiotyków wp?ywa?o na znamienn? statystycznie popraw? przebiegu choroby. Poprawa stanu klinicznego po 3 miesi?cach leczenia by?a obserwowana u 93% dzieci przyjmuj?cych probiotyki, podczas gdy w grupie kontrolnej u 54% (p=0,0329). Po dalszych 5 miesi?cach obserwacji odsetek dzieci wykazuj?cych popraw? w grupie kontrolnej zwi?k­szy? si? do 85%, natomiast w grupie badanej wynosi? 93% (p=0,079). Wnioski: Nasze badania pokazuj?, ?e szczepy Lactobacullus casei i paracasei poprawiaj? stan kliniczny pacjentów z WA, ale tylko u dzieci z alergi? IgE-zale?n?.

Bo?ena Cukrowska; Aldona Ceregra; Ilona Rosiak; El?bieta Klewicka; Katarzyna Sli?ewska; Ilona Motyl; Zdzis?awa Libudzisz

2008-01-01

95

Assessment of Bcl-2 and Bcl-XL proteins expression level during the course of various types of skin ageing. Ocena stopnia ekspresji bia?ek Bcl-2 i Bcl-XL w przebiegu ró?nego typu starzenia si? skóry.  

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Full Text Available Wprowadzenie: Mi?dzy takimi procesami, jak starzenie si?, apoptoza i nowotworzenie istniej? pewne zale?no?ci. Komórka albo starzeje si? albo ulega apoptoziepo to, ?eby nie sta? si? komórk? nowotworow?. Du?? rol? w regulacji tego procesu odgrywaj? bia?ka z grupy Bcl-2.Cel pracy: Ocena stopnia ekspresji bia?ka Bcl-2 oraz Bcl-XL w przebiegu starzenia chronologicznego, menopauzalnego i fotostarzenia si? w obr?bie naskórka i skóryw?a?ciwej.Materia? i metody: Badaniem obj?to grup? 60 zdrowych kobiet z ró?nymi objawami starzenia si? skóry w wieku od 26. do 62. r.?., które wyrazi?y dobrowolniezgod? na wzi?cie udzia?u w projekcie badawczym. Wyodr?bniono 3 niezale?ne grupy, ka?da licz?ca po 20 osób. Grup? I stanowi?y kobiety z objawami menopauzalnegostarzenia si? skóry, grup? II - z objawami fotostarzenia si?, a III - z objawami starzenia si? chronologicznego. Po ocenie stanu skóry od wszystkich badanychpobierano z okolicy przedusznej wycinek do bada? immunohistochemicznych.Wyniki bada?: Analizuj?c stopie? ekspresji bia?ek bior?cych udzia? w apoptozie, nie stwierdzono istotnych statystycznie ró?nic mi?dzy stopniem ekspresji Bcl-XLw badanych grupach. Porównuj?c stopie? ekspresji bia?ka Bcl-2 w skórze w?a?ciwej wykazano istotn? ró?nic? statystyczn? mi?dzy grupami I a II oraz blisko istotno?ci statystycznej mi?dzy grupami II a III.Wnioski: Istnieje znamiennie cz?stsza i silniejsza ekspresja bia?ka Bcl-2 w przebiegu fotostarzenia si?. Nie ma charakterystycznych ró?nic w ekspresji Bcl-XL mi?dzy poszczególnymi typami starzenia si?.

Barbara Zegarska; Wojciech Jó?wicki; Waldemar Placek; Alina Grzanka

2009-01-01

96

Obraz morfologiczny b?ony ?luzowej dwunastnicy u starszych dzieci z wywiadem obci??onym alergi? na bia?ka mleka krowiego w okresie niemowl?cym. Badania immunohistochemiczne i morfometryczne  

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Full Text Available Wprowadzenie: Obserwacje kliniczne i wyniki bada? wskazuj? na to, ?e alergia pokarmowa okresu niemowl?cego mo?e przetrwa? i manifestowa? si? w pó?niejszym wieku w formie opó?nionych reakcji obejmuj?cych g?ównie przewód pokarmowy. Cel pracy: Ocena morfologiczna b?ony ?luzowej dwunastnicy u dzieci z bólami brzucha i wywiadem obci??onym alergi? na bia?ka mleka krowiego w okresie niemowl?cym. Materia? i metodyka: Badaniami obj?to 30 dzieci z bólami brzucha i z alergi? na bia?ka mleka krowiego w okresie niemowl?cym (grupa A), 56 dzieci z bólami brzucha bez cech alergii pokarmowej (grupa B) oraz 20 dzieci diagnozowanych z powodu niskiego wzrostu i nie-dokrwisto?ci (grupa C). U pacjentów przeprowadzono badania alergologiczne oraz gastroskopi? w celach diagnostycznych z pobraniem wycinków b?ony ?luzowej dwunastnicy. Przy u?yciu przeciwcia? monoklonalnych oznaczano komórki CD3+, CD8+, CD20+, komórki tuczne oraz komórki proliferuj?ce (Ki67). Pomiary d?ugo?ci kosmków jelitowych dwunastnicy przeprowadzono przy wykorzystaniu zestawu z oprogramowaniem morfometrycznym Microlmage InCD UDF Olympus. Wyniki: U wszystkich badanych wyniki testów skórnych z alergenami pokarmowymi by?y ujemne; w surowicy nie stwierdzono IgE specyficznych dla bia?ek mleka krowiego. U pacjentów obci??onych alergi? pokarmow? okresu niemowl?cego liczba limfocytów CD3+ w b?onie ?luzowej dwunastnicy by?a wy?sza w stosunku do pacjentów grupy B i C. Nie stwierdzono ró?nic w ilo?ci komórek CD8+ i mastocytów oraz odsetka proliferuj?cych enetrocytów w dwunastnicy badanych pacjentów z poszczególnych grup. Wysoko?? kosmków jelitowych, g??boko?? krypt gruczo?owych by?a zbli?ona u wszystkich pacjentów. Wnioski: U dzieci obci??onych alergi? pokarmow? okresu niemowl?cego stwierdza si? w wieku pó?niejszym wyk?adniki wzmo?onej odpowiedzi immunologicznej b?ony ?luzowej przewodu pokarmowego pod postaci? zwi?kszonej liczby limfocytów T.

El?bieta Jarocka-Cyrta; Joanna Pawlak; Magda Topczewska; Maciej Kaczmarski

2007-01-01

97

The role of land-use visions for protection of forest landscapes: the Bia?owie?a Forest (Poland) El rol de las visiones del uso del suelo en la protección de los paisajes forestales: el bosque de Bialowieza (Polonia)  

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Full Text Available The work concentrated on relations between the issues of use and protection that developed in the Polish part of the Bia?owie?a Forest last century, particularly during the post-war decades. Owing to extraordinary natural values, the area deserves very careful protection, however, negative impacts on the landscape have been widely observed. The changes involving perforation and fragmentation of forest cover caused by continuous logging are accompanied by spatial disorder in built areas and their vicinities resulting from tourism development. The aim of the research was to identify the underlying forces of negative tendencies and simultaneously, obstacles to progress in nature conservation of the area. Comparison of views and visions of land-use and management of the Forest showed that great differences in attitudes, applied perspectives and expectations to the Bia?owie?a Forest exist. The study revealed the importance of a socio-cultural dimension for a current stage of landscape evolution. This influence is connected with a steady pressure on wood exploitation and results, at least partially, from a strong position of forest administration in this area and from specific land-use visions emphasizing economic services of the forest. Noteworthy, actions undertaken across the country and numerous efforts to extend protection of the area have not succeeded so far. It is argued that underestimation of natural values expressed by local communities in addition to weaknesses of the state’s environmental law may bring serious hazards to the analysed landscape and affect the whole system of nature conservation in Poland.Esta investigación estudió las relaciones entre el uso y protección del bosque Bia?owie?a, Polonia, durante el último siglo, particularmente en las décadas de la post-guerra. Debido a los extraordinarios valores naturales, esta área necesita una protección muy especial. Sin embargo, se han observado diversos impactos negativos sobre el paisaje. Los cambios implicaron perforación y fragmentación del bosque causados por la continua tala de árboles, debido a la expansión urbana asociada al desarrollo turístico. El objetivo de esta investigación fue identificar los forzantes subyacentes de tendencia negativa y los obstáculos para el progreso de la conservación de la naturaleza en la zona. Comparación de puntos de vista, visiones de uso del suelo y manejo del bosque, evidenciaron importantes diferencias en actitudes, perspectivas y expectativas aplicadas al bosque de Bia?owie?a. El estudio reveló la importancia de la dimensión socio-cultural en el estado actual de evolución del paisaje. Esta influencia está relacionada con una presión constante sobre la explotación maderera, por lo menos parcialmente, desde una fuerte posición de la administración forestal en esta área y desde visiones específicas de uso de suelo que enfatizan los servicios económicos de los bosques. Cabe destacar, que acciones realizadas en todo el país y los numerosos esfuerzos para ampliar las áreas de protección no han tenido éxito hasta el momento. Se argumenta que la subestimación de los valores naturales expresada por las comunidades locales, además de las debilidades de la legislación ambiental del Estado, pueden traer serias amenazas para el paisaje analizado y afectar a todo el sistema de conservación de la naturaleza en Polonia.

Barbara Bo??tka

2012-01-01

98

Ocena poziomu poszczególnych komórek uk?adu bia?okrwinkowego u chorych z ostrym ?ó?ciopochodnym zapaleniem trzustki po przebytej wcze?niej cholecystektomii we wczesnym okresie choroby  

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Full Text Available Wprowadzenie: Poza kilkoma doniesieniami brak jest prac opisuj?cych przebieg ostrego zapalenia trzustki (o.z.t.) u chorych po przebytej wcze?niej cholecystektomii. Brakuje równie? informacji o sposobie leczenia takich chorych. Jedn? z metod monitorowania procesu zapalnego w o.z.t. jest pomiar poziomu poszczególnych komórek uk?adu bia?okrwinkowego. Cel pracy: Porównanie ?rednich poziomów oraz zmian w czasie poszczególnych elementów uk?adu bia?okrwinkowego w dwóch grupach chorych z lekkim ?ó?ciopochodnym o.z.t. Materia? i metody: Pierwsz? grup? stanowi?o 54 chorych z kamic? p?cherzyka ?ó?ciowego (grupa Ch), natomiast drug? grup? 15 chorych bez p?cherzyka ?ó?ciowego (chorzy po przebytej wcze?niej cholecystektomii - grupa P). Obie grupy leczone by?y w ten sam sposób i mia?y wykonan? w pierwszej dobie endoskopow? sfinkterotomi?. Wyniki: W grupie Ch obserwowane by?y nieznacznie wy?sze poziomy leukocytozy, neutrofilów i monocytów. W obu grupach obni?enie poziomów tych komórekw miar? leczenia post?powa?o podobnie. Nie zanotowano ró?nic w d?ugo?ci pobytu w szpitalu pomi?dzy grupami. Ponadto okaza?o si? ?e poziom limfocytów mierzony w pierwszym dniu leczenia koreluje z d?ugo?ci? hospitalizacji. Wnioski: Uwa?amy, ?e podwy?szony poziom leukocytozy, neutrofilów i monocytów w grupie Ch mo?e wynika? z obecno?ci p?cherzyka wype?nionego z?ogami jako ?ród?a dodatkowego ogniska zapalenia. Podobna dynamika zmian leukocytów (spadek) oraz brak ró?nic w czasie hospitalizacji w obu grupach ?wiadczy o skutecznej metodzie leczenia, która mo?e by? polecona w obu przypadkach.

Józefa Panek; Danuta Karcz; Kazimierz Rembiasz; Jakub Zasada; Marcin Strza?ka

2006-01-01

99

Wp?yw leczenia streptokinaz? na generacj? trombiny, aktywno?? sk?adników uk?adów dope?niacza i czynników kontaktu oraz st??enie bia?ka C-reaktywnego u chorych z zawa?em serca  

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Full Text Available Wprowadzenie: Streptokinaza, oprócz dominuj?cej aktywacji plazminy, wzmaga generacj? trombiny. Po jej podaniu obserwowano podwy?szony poziom sk?adowych dope?niacza C3, C4 i kompleksu uszkadzaj?cego struktur? b?ony, a tak?e aktywacj? kininogenu, bradykininy oraz czynnika XII i kalikreiny. Cel pracy: Okre?lenie dynamiki zmian markerów uk?adu trombiny, dope?niacza i kontaktu oraz bia?ka C-reaktywnego w okresie ostrym i do trzech miesi?cy od wyst?pienia zawa?u w grupie chorych leczonych streptokinaz?. Materia? i metodyka: Badaniem obj?to 45 pacjentów z pierwszym zawa?em mi??nia serca (29 m??czyzn i 16 kobiet), w wieku 60±;10 lat, hospitalizowanych 4±;2 godz. od wyst?pienia bólu. U 25 pacjentów rozpoznano zawa? ?ciany dolnej a u 20 przedniej. Próbki krwi ?ylnej pobrano przed podaniem streptokinazy, kolejne w 30, 60 i 120 min oraz 6, 24 i 48 godz. od pocz?tku wlewu, nast?pnie w 7, 14, 30 i 90 dobie od zawa?u. U wszystkich chorych oznaczono st??enie kompleksów trombina–antytrombina, fragmenty F1+2, poziom sk?adowych dope?niacza C3, C4, st??enie i aktywno?? C1-inhibitora, aktywno?? czynników XI i XII oraz st??enie bia?ka C-reaktywnego (CRP – C-reactive protein). Wyniki: St??enia TAT i F1+2 przekracza?y górne granice normy; maksymalny wzrost wyst?pi? w 60 min wlewu strepokinazy; TAT wzrós? z 12,7 do 120,3 ug/l, F1+2 z 3,2 do 22,6 nmol/l, p<0,05. Wzrost aktywno?ci uk?adu dope?niacza mia? miejsce pomi?dzy 7 a 14 dob?, odpowiednio: C3 od 1,43 do 1,79 g/l, st??enie antygenu C1 inhibitora od 0,31 do 0,37 g/l, a jego aktywno?? od 79 do 96%, p<0,05. St??enie CRP wzros?o znamiennie pomi?dzy 1 a 7 dob?, od 7,5 do maksimum 52 mg/l, p<0,05. Aktywno?ci czynników XI i XII oscylowa?y wokó? warto?ci prawid?owych i nie uleg?y istotnym zmianom. Wnioski: Zastosowanie streptokinazy w terapii zawa?u serca spowodowa?o odmienn? dynamik? zmian markerów generacji trombiny (szczyt w 60 min), bia?ka C-reaktywnego (szczyt w 48 godz.) i uk?adu dope?niacza (szczyt w 14 dobie).

Zofia Ska?uba; Tomasz Brzostek; Janusz Maciejewicz; Monika Franczyk; Marek Grzywacz; Zofia Szwalec; Jacek Musia?; Andrzej Szczeklik

2004-01-01

100

Ocena poziomu mRNA bia?ka Fragile Histidine Triad (FHIT) w b?onie ?luzowej ?o??dka u pacjentów z objawami dyspepsji niewrzodowej w zale?no?ci od na?ogu palenia tytoniu i infekcji Helicobacter pylori  

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Full Text Available Wprowadzenie: Sk?onno?ci dziedziczne i czynniki ?rodowiskowe zwi?kszaj? osobnicze ryzyko wyst?pienia raka ?o??dka, szczególnie u osób nara?onych na czynniki ?rodowiskowe takie jak infekcja Helicobacter pylori (H. pylori) i na?óg palenia papierosów. W raku ?o??dka dochodzi do obni?enia lub ca?kowitej utraty ekspresji genu proapoptycznego bia?ka FHIT (fragile Histidine Triad). Cel pracy: Odpowied? na pytanie, czy u H. pylori dodatnich i ujemnych pacjentów z dyspepsj? ekspresja genu FH/Ijest uzale?niona od na?ogu palenia papierosów. Materia? i metody: Poziom mRNA bia?ka FHIT w b?onie ?luzowej ?o??dka (po dwa bioptaty z cz??ci przedod?wiernikowej i trzonu) oznaczono metod? RT-PCR (reverse transcription polymerase chain reaction) w czasie rzeczywistym. Kolonizacj? H. pylori okre?lono za pomoc? testu ureazo-wego, badania histopatologicznego i polimerazowej reakcji ?a?cuchowej (polymerase chain reaction - PCR). Badaniami obj?to 41 pacjentów z dyspepsj? w wieku 28-61 lat (?rednia wieku 45,3 lat) podzielonych na dwie grupy: grupa I - 29 pacjentów niepal?cych (19 H. pylori+), grupa II - 12 palaczy papierosów (8 H. pylori+). Wyniki: Poziom mRNA bia?ka FHITwbioptatach pobranych z cz??ci przedod?wiernikowej od palaczy tytoniu nie zaka?onych H.py/ori jest obni?ony o 40% w stosunku do poziomu mRNA tego bia?ka w bioptatach pacjentów niepal?cych (p<0,05). Ró?nicy takiej nie zaobserwowano u pacjentów zaka?onych H. pylori w cz??ci przedod?wiernikowej oraz w trzonie ?o??dka u pacjentów obu grup, niezale?nie od infekcji bakteryjnej. Wnioski: Palenie tytoniu ma istotne znaczenie w obni?eniu poziomu ekspresji genu proapoptycznego bia?ka FHIT w cz??ci przedod?wiernikowej ?o??dka u osób z dyspepsj? bez wspó?istniej?cej infekcji H. pylori.

Krystyna Stec-Michalska; ?ukasz P?czek; Agnieszka Krakowiak; Gra?yna Klupi?ska; Jan Chojnacki; B?a?ej Michalski; Barbara Nawrót

2006-01-01

 
 
 
 
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Niedo?ywienie a uk?ad odporno?ciowy – charakterystyka fenotypowa limfocytów krwi obwodowej a zawarto?? interleukiny-12 w surowicy u dzieci z niedo?ywieniem bia?kowo-kalorycznym  

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Full Text Available Wprowadzenie: Niedo?ywienie bia?kowo-kaloryczne (NB-K) obni?a odporno?? zwi?zan? z reakcj? immunologiczn? typu komórkowego. Ogranicza bowiem procesy proliferacji i dojrzewania limfocytów. Kluczow? rol? w tych procesach odgrywa interleukina-12 (IL-12). Cel pracy: Zbadanie mechanizmów, poprzez które NB-K wp?ywa na uk?ad odporno?ciowy u dzieci. Materia? i metodyka: U 50 dzieci z NB-K przeprowadzono badanie podmiotowe i przedmiotowe. Metod? rutynow? badano morfologi? krwi a metod? cytometrii przep?ywowej – liczebno?? populacji limfocytów T (CD3+), LB (CD19+), LTh (CD4+), LTc/s (CD8+), aktywnych LT (CD3+HLA DR+) i komórek NK (CD56+). Ponadto metod? ELISA oznaczono zawarto?? w surowicy IL-12 Wyniki: Masa cia?a i wska?nik wzgl?dnej masy cia?a (BMI – body mass index) by?y obni?one poni?ej 3 centyla u 49 dzieci a mi?dzy 3 a 10 centylem u 1 dziecka. U 38% dzieci stwierdzono obni?enie ca?kowitej liczby limfocytów we krwi. Badanie cytometryczne wykaza?o redukcj? liczebno?ci populacji LB u 56% dzieci, LT u 52%, LT CD8+ u 56%, LT CD4+ u 36%, natomiast LT HLA DR+ w 74% przypadków, a komórek NK u 62% dzieci. Stwierdzono znamienn? statystycznie dodatni? korelacj? mi?dzy zawarto?ci? IL-12 w surowicy a ca?kowit? liczb? LT we krwi oraz liczebno?ci? poszczególnych subpopulacji LT (r=0,41 do 0,54, p<0,05). Wnioski: 1. U dzieci z NB-K stwierdza si? zmniejszenie liczebno?ci poszczególnych populacji limfocytów krwi obwodowej; mo?e to mie? zwi?zek z deficytem odporno?ci, zw?aszcza typu komórkowego. 2. W stanach NB-K istnieje korelacja mi?dzy zawarto?ci? IL-12 w surowicy a liczebno?ci? populacji limfocytów krwi obwodowej.

Krzysztof Marek; Andrzej Marek; Maria Korzon

2004-01-01

102

Analysis of Suitability for Development of New Mining Field in Northern Part of Kosovo Lignite Basin - Sibovc / Analiza Mo?liwo?ci Udost?pnienia Nowego Obszaru Wybierania W Pó?nocnej Cz??ci Zag??bia W?gla Brunatnego Sibovc W Kosowie  

Science.gov (United States)

This review describes the possibility of development a new lignite deposit in northern Kosovo lignite basin - Sibovc. Analysis of the initial state briefly evaluates Kosovo energy sector, geomorphological conditions and quality of lignite from Sibovc deposit. With using Dataminesoft it was created geological model and approximate calculation of lignite reserves in the deposit. The data obtained from Dataminesoft were used as starting points of the financial analysis of project. The result of the analysis is exactly describe the qualitative and quantitative characteristics of deposit Sibovc compared to other deposits in the area and creating of geological model with productive horizons deposit of lignite. Based on these data lignite deposit Sibovc was classified, according to the classification of deposits the UN, as economical. W pracy tej omówiono mo?liwo?ci udost?pnienia nowego obszaru wybierania z?o?a w?gla brunatnego (lignitu) w pó?nocnej cz??ci zag??bia w?gla brunatnego Sibovc w Kosowie. W analizie stanu pocz?tkowego krótko scharakteryzowano sektor energetyczny Kosowa, warunki geo-morfologiczne oraz parametry jako?ciowe w?gla brunatnego z zag??bia Sibovc. Przy pomocy pakietu Dataminesoft stworzono model geologiczny i przeprowadzono przybli?one obliczenia zasobów w?gla brunatnego w z?o?u. Dane uzyskane przy zastosowaniu pakietu Dataminesoft zosta?y nast?pnie wykorzystane jako dane wej?ciowe do analizy finansowej przedsi?wzi?cia. Na podstawie wyników analizy uzyskuje si? jako?ciow? i ilo?ciow? charakterystyk? z?o?a w odniesieniu do pozosta?ych z?ó? w regionie. Opracowano model geologiczny ze szczegó?owym wskazaniem poziomów wybierania lignitu. W oparciu o te dane dokonano klasyfikacji z?o?a w?gla brunatnego (lignitu) w Sibovc zgodnie z mi?dzynarodowymi zasadami klasyfikacji wykazuj?c, ?e z?o?e b?dzie ekonomiczne.

Cehlár, Michal; Rybár, Radim; Pinka, Ján; Haxhiu, Lorik; Beer, Martin

2013-06-01

103

G?ówne bia?ko zasadowe eozynofilów (eosinophil major basic protein - MBP), IL-5, elastaza neutrofilowa i IL-8 w skórze zmienionej p?cherzowo a surowicze przeciwcia?a IgG przeciwko NC16a w ludzkim pemfigoidzie p?cherzowym  

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Full Text Available Wst?p: Uwa?a si?, ?e fragment NC16a kolagenu typu XVII obejmuje najbardziej istotne autoepitopy w patogenezie pemfigoidu p?cherzowego (BP). Wi?kszo?? bada? na modelach zwierz?cych i cz??? na populacji ludzkiej sugeruje, ?e neutrofile, a nie eozynofile, s? kluczowymi komórkami w BP. Cel pracy: Porównanie znaczenia IL-5, IL-8, g?ównego bia?ka zasadowego eozynofilów (MBP) i elastazy neutrofilowej (NE) w ludzkim BP na poziomie tkanki w odniesieniu do poziomu surowiczych przeciwcia? IgG przeciwko NC16a. Materia? i metody: Badaniami obj?to 51 przypadków BP i 77 chorych kontrolnych z innymi autoimmunizacyjnymi i nieautoimmunizacyjnymi dermato-zami p?cherzowymi. MBP w skórze obejmuj?cej ?wie?y p?cherz wykrywano technik? immunohistochemiczn? streptawidyna/peroksydaza. Poziomy IL-5, IL-8, NE w p?ynie p?cherzowym oraz IL-5 i przeciwcia?a IgG anty-NC16a w surowicy badano technikami ELISA. Wyniki: MBP wykryto w p?cherzowo zmienionej skórze u 54% chorych na BP i tylko u 30% chorych kontrolnych. W grupie chorych z BP st??enie IL-5 w p?ynie p?cherzowym by?o znamiennie wi?ksze od st??enia w surowicy, a tak?e od poziomu w p?ynach kontrolnych. Poziomy IL-8 i NE w p?ynach BP nie ró?ni?y si? znamiennie od poziomów w p?ynach kontrolnych. Nie stwierdzono znamiennej zale?no?ci mi?dzy obecno?ci? MBP w wykwitach BP a poziomami IL-5 w p?ynach BP i poziomami surowiczych przeciwcia? IgG anty-NC16a, ani znamiennej zale?no?ci mi?dzy poziomem NE w p?ynach BP a poziomami IL-8 w p?ynach BP i poziomami surowiczych przeciwcia? IgG anty-NC16a, ani te? znamiennej zale?no?ci mi?dzy poziomami surowiczych przeciwcia? IgG anty-NC16a a poziomami IL-5 i IL-8 w p?ynach BP. Wnioski: W tkance u chorych na BP dzia?ania IL-5 i MBP mog? mieæ istotniejsze znaczenie od dzia?a? IL-8 i NE. Dzia?anie IL-5 wydaje si? niepowi?zane z poziomem surowiczych przeciwcia? IgG anty-NC16a i obecno?ci? MBP w wykwitach.

Gra?yna Wolnik-Trzeciak; Aleksandra Da?czak-Pazdrowska; Monika Bowszyc-Dmochowska; Marian Dmochowski

2005-01-01

104

Body composition assessment in nutrition research: value of BIA technology.  

UK PubMed Central (United Kingdom)

BACKGROUND/OBJECTIVES: There is wide variability in the shape and size of an individual and their body composition. This partly reflects inherent genetic differences, but to a large extent is determined by the extent to which their intake of energy and nutrients has adequately matched their needs over extended periods of time. SUBJECTS/METHODS: During childhood, the effective partitioning of nutrients to tissues reflects the hierarchy of demand for growth and maturation during critical periods of development. At all ages, the structural relationships at the molecular, cellular, tissue and whole-body levels are indicative of functional capability and the capacity to cope with internal and external stresses. RESULTS: Reliable measurements of body composition and their interpretation can mark health, be indicative of the risk of ill-health and be a direct cause of pathology and disease. The bioelectrical impedance of the body has been used as an indirect measure for body composition, because it is a reflection of both its structural and functional characteristics, but the specifics of the relationships between these considerations still need to be determined. CONCLUSIONS: The measurement of bioelectrical impedance is simple to carry out and is non-invasive. It could be further refined and developed to fully explore and exploit its potential utility in practice.

Jackson AA; Johnson M; Durkin K; Wootton S

2013-01-01

105

Mechanisms of Action of Carbamazepine and Its Derivatives, Oxcarbazepine, BIA 2-093, and BIA 2-024  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Carbamazepine (CBZ) has been extensively used in the treatment of epilepsy, as well as in the treatment of neuropathic pain and affective disorders. However, the mechanisms of action of this drug are not completely elucidated and are still a matter of debate. Since CBZ is not very effective in some ...

Ambrósio, António F.; Soares-da-Silva, Patrício; Carvalho, Caetana M.; Carvalho, Arsélio P.

106

Análise dos resultados do uso precoce e tardio da assistência circulatória com balão intra-aórtico (BIA) em pacientes submetidos a correção de cardiopatias com auxílio de circulação extracorpórea Analysis of the early and late use of the intra-aortic balloon pump as a method of mechanical support for the management of patients with low output syndrome, following cardiac surgery with cardiopulmonary bypass  

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Full Text Available Este estudo tem como objetivo, a análise retrospectiva do uso precoce (intra-operatório) e tardio (pós-operatório) do balão intra-aórtico. Foram estudados 130 pacientes do Texas Heart Institute, no período de janeiro a dezembro de 1987, sendo 103 do sexo masculino e 27 do sexo feminino; a idade média dos pacientes foi de 61,5 ± 10,76 (14 a 84) anos, a média de peso foi de 75,5 ± 16,6 (42 a 134) kg, a média de superfície corpórea de 1,87 ± 0,24 (1,08 a 2,60)m² e um tempo médio de circulação extracorpórea de 98 (33 a 299) minutos e de pinçamento aórtico de 49 (10 a 122) minutos. O balão intra-aórtico foi usado em todos os pacientes por baixo débito cardíaco, em 4 associado a disrritmias retratarias a tratamento clínico e 2 por parada cardiorrespiratória, por períodos que variaram de 15 minutos a 256 horas. Os pacientes foram divididos em 6 grupos; Grupo I, pacientes que receberam o balão intra-aórtico no intra-operatório (precoce), Grupo II, pacientes que receberam o balão intra-aórtico no pós-operatório (tardio), Grupo III (pacientes com idade igual ou inferior a 65 anos), Grupo IV (pacientes com idade superior a 65 anos), Grupo V (pacientes com tempo de circulação extracorpórea de até 120 minutos) e Grupo VI (pacientes com tempo de circulação extracorpórea superior a 120 minutos) e 2 subdivisões nos grupos V e VI, subgrupo 1/. (pacientes com tempo de pinçamento de aorta menor ou igual a 60 minutos) e subgrupo 2/. (pacientes com tempo de pinçamento de aorta maior que 60 minutos). Dos 130 pacientes submetidos ao BIA, 81 (62.3%) sobreviveram e 49 (37,7%) pacientes faleceram; destes, 38 (36,2%) pertenciam ao Grupo I e 11 (44%) ao Grupo II. A sobrevida foi maior no Grupo III (68,6%) e menor no Grupo IV (51%) com pThe purpose of this study was to evaluate the intra-aortic balloon pump as a method of mechanical support for the management of patients with low output syndrome, following cardiac surgery with cardiopulmonary bypass. The results with early (intra-operative) and late (post-operative) support were compared, as well as the relationship among cardiopulmonary bypass time, aortic clamp time and mortality. Pre-operative left ventricle ejection fraction, as a prognosis index, and complications rates were also analysed. One hundred and thirty patients from Texas Heart Institute, during the period of January to December 1987, were studied retrospectively; there were 103 men and 27 women, with a mean age of 61.5 ± 10.7 (14 to 84) years. The mean weight body and body surface area were 75.5 ± 16.6 (42 to 134) kilograms and 1.87 ± 0.24 (1.08 to 2.60) square meters respectively. The mean time of cardiopulmonary bypass was 98 (33 to 299) minutes and the mean time of aortic clamp was 49 (10 to 122) minutes. All the patients had low cardiac output, associated with refractary arrythmias in 4 and after cardiac arrest in the intensive care unit in 2 patients. The intra-aortic balloon pump was left for variable periods of time from 15 minutes to 256 hours. The all cohort was divided in six groups, according to the early (intra-operative) insertion of the balloon pump (Group I), the late (post-operative) insertion (Group II), patient's age equal or inferior to 65 years Group III and Group IV age superior to 65 years, Group V and VI according cardiopulmonary bypass time up to 120 or superior to 120 minutes, and both were divided according to aortic clamp time (subgroup 1, up to 60 minutes and subgroup 2, superior to 60 minutes). The outcome was successful in 81 (62.3%) and 49 (37.7%) died (36.2% from Group I and 44% from Group II). The survival rate was greater in Group III (68.6%) than in Group IV (51 %) with p<0.05 showing statistical relevance of mortality in the older group. There were no significant associations between ejection fraction, aortic clamp time versus mortality but cardiopulmonary bypass had high statistical significance with p<0.01 for times over 120 minutes. Complications were found in 6 patients (4.6%). These data suggest that intra-aortic balloon pump

Hugo de Moraes Sarmento Macruz; Oscar Howard Frazier; Denton A Cooley

1995-01-01

107

Análise dos resultados do uso precoce e tardio da assistência circulatória com balão intra-aórtico (BIA) em pacientes submetidos a correção de cardiopatias com auxílio de circulação extracorpórea/ Analysis of the early and late use of the intra-aortic balloon pump as a method of mechanical support for the management of patients with low output syndrome, following cardiac surgery with cardiopulmonary bypass  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese Este estudo tem como objetivo, a análise retrospectiva do uso precoce (intra-operatório) e tardio (pós-operatório) do balão intra-aórtico. Foram estudados 130 pacientes do Texas Heart Institute, no período de janeiro a dezembro de 1987, sendo 103 do sexo masculino e 27 do sexo feminino; a idade média dos pacientes foi de 61,5 ± 10,76 (14 a 84) anos, a média de peso foi de 75,5 ± 16,6 (42 a 134) kg, a média de superfície corpórea de 1,87 ± 0,24 (1,08 a 2,60) (more) m² e um tempo médio de circulação extracorpórea de 98 (33 a 299) minutos e de pinçamento aórtico de 49 (10 a 122) minutos. O balão intra-aórtico foi usado em todos os pacientes por baixo débito cardíaco, em 4 associado a disrritmias retratarias a tratamento clínico e 2 por parada cardiorrespiratória, por períodos que variaram de 15 minutos a 256 horas. Os pacientes foram divididos em 6 grupos; Grupo I, pacientes que receberam o balão intra-aórtico no intra-operatório (precoce), Grupo II, pacientes que receberam o balão intra-aórtico no pós-operatório (tardio), Grupo III (pacientes com idade igual ou inferior a 65 anos), Grupo IV (pacientes com idade superior a 65 anos), Grupo V (pacientes com tempo de circulação extracorpórea de até 120 minutos) e Grupo VI (pacientes com tempo de circulação extracorpórea superior a 120 minutos) e 2 subdivisões nos grupos V e VI, subgrupo 1/. (pacientes com tempo de pinçamento de aorta menor ou igual a 60 minutos) e subgrupo 2/. (pacientes com tempo de pinçamento de aorta maior que 60 minutos). Dos 130 pacientes submetidos ao BIA, 81 (62.3%) sobreviveram e 49 (37,7%) pacientes faleceram; destes, 38 (36,2%) pertenciam ao Grupo I e 11 (44%) ao Grupo II. A sobrevida foi maior no Grupo III (68,6%) e menor no Grupo IV (51%) com p Abstract in english The purpose of this study was to evaluate the intra-aortic balloon pump as a method of mechanical support for the management of patients with low output syndrome, following cardiac surgery with cardiopulmonary bypass. The results with early (intra-operative) and late (post-operative) support were compared, as well as the relationship among cardiopulmonary bypass time, aortic clamp time and mortality. Pre-operative left ventricle ejection fraction, as a prognosis index, an (more) d complications rates were also analysed. One hundred and thirty patients from Texas Heart Institute, during the period of January to December 1987, were studied retrospectively; there were 103 men and 27 women, with a mean age of 61.5 ± 10.7 (14 to 84) years. The mean weight body and body surface area were 75.5 ± 16.6 (42 to 134) kilograms and 1.87 ± 0.24 (1.08 to 2.60) square meters respectively. The mean time of cardiopulmonary bypass was 98 (33 to 299) minutes and the mean time of aortic clamp was 49 (10 to 122) minutes. All the patients had low cardiac output, associated with refractary arrythmias in 4 and after cardiac arrest in the intensive care unit in 2 patients. The intra-aortic balloon pump was left for variable periods of time from 15 minutes to 256 hours. The all cohort was divided in six groups, according to the early (intra-operative) insertion of the balloon pump (Group I), the late (post-operative) insertion (Group II), patient's age equal or inferior to 65 years Group III and Group IV age superior to 65 years, Group V and VI according cardiopulmonary bypass time up to 120 or superior to 120 minutes, and both were divided according to aortic clamp time (subgroup 1, up to 60 minutes and subgroup 2, superior to 60 minutes). The outcome was successful in 81 (62.3%) and 49 (37.7%) died (36.2% from Group I and 44% from Group II). The survival rate was greater in Group III (68.6%) than in Group IV (51 %) with p

Macruz, Hugo de Moraes Sarmento; Frazier, Oscar Howard; Cooley, Denton A

1995-12-01

108

Immunoekspresja bia?ek zwi?zanych z apoptoz? i proliferacj? w surowiczych nowotworach jajnika  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction: Ovarian cancer takes fourth place as a cause of death from all cancers and first place fromgynaecological malignancies in Poland. Recent investigations have noted the prognostic significance of proteinslinked with proliferation (Ki-67) and apoptosis (CAS – cellular apoptosis susceptibility protein).The aim of the study was to evaluate the immunoexpression of CAS and Ki-67 proteins in metastatic andnon-metastatic serous ovarian tumours, as well as to find possible relationships between this immunoexpressionand tumour proliferation activity. Material and methods: The analysis comprised 43 women diagnosed and treated for malignant epithelialovarian tumours. The immunoexpression of CAS protein was assessed semiquantitatively, whereas immunoexpressionof Ki-67 was performed using a computer image analysis system. Results: The immunoexpression of both CAS and Ki-67 proteins was significantly increased in the metastaticgroup as compared with patients without metastases. Also, a positive correlation was found between immunoexpressionof Ki-67 and CAS protein, but this correlation was not significant. Conclusions: In conclusion, our data suggest that increased immunoexpression of CAS and Ki-67 proteins inserous ovarian tumours may be helpful in identifying cases of higher metastatic potential.

Pawe? Stawerski; Ma?gorzata W?growska-Danilewicz; Olga Stasikowska; Marian Danilewicz

2010-01-01

109

Coupling IR Thermography and BIA to analyse body reaction after one acupuncture session  

Science.gov (United States)

Coupling both thermography and bio-Impedance, some biophysical acupuncture mechanisms are statically studied on a small population of 18 subjects. Results show that a possible way of understanding acupuncture, in an electrical way, should be to consider ionic flux redistribution between vascular and extra cell compartments. This is a two steps mechanism. The first one is starting with needles insertion and the second one is lasting with more intensity after removing them from skin.

Piquemal, M.

2013-04-01

110

Glukagon i bia?ka glukagonopodobne i ich rola w metabolizmie glukozy. Cz??? I  

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Full Text Available Homeostaza glukozy jest kontrolowana g?ównie przez przeciwdzia?ajace hormony, insulin? i glukagon, wydzielane w wyspach trzustki przez komorki ? i komórki ?, a tak?e komorki ?, których rola w homeostazie glukozy wymaga jeszcze wyja?nienia. Sekrecja insuliny wzrasta w odpowiedzi na wzrost st??enia glukozy dla utrzymania normoglikemii przez stymulacj? transportu glukozy w mi??niach i tkance t?uszczowej i redukcji produkcji glukozy poprzez hamowanie glukoneogenezy w w?trobie. Sekrecja glukagonu jest obni?ana przez hiperglikemi?, a stymulowana podczas hipoglikemii dla promocji produkcji glukozy w celu podwy?szenia poziomu glukozy. Sekrecja glukagonu przez komórki ? jest regulowana przez ró?ne mechanizmy w??czaj?c glikemi?, b?d?ce nerwowe i sekrecj? insuliny z s?siaduj?cych komorek ?. Glukagon, dzia?aj?c na w?trob?, pierwotnie inicjuje glikogenoliz? i glukoneogenez?, w rezultacie czego dochodzi do szybkiego wzrostu endogennej produkcji glukozy. Przy przed?u?aj?cej si? stymulacji glukagon, dzia?aj?c na w?trob? dla zaoszcz?dzenia glukozy, aktywuje oksydacj? wolnych kwasow tluszczowych i produkcj? ketonow.

Ewa Otto-Buczkowska

2011-01-01

111

Ouvindo Bia e buscando novos caminhos na formação permanente de professores de matemática  

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Full Text Available Desenvolvendo uma análise de natureza qualitativa, cujos parâmetros estão radicados na fenomenologia, apresentamos, nesse artigo, uma tentativa de buscar analisar e compreender aspectos da formação permanente (uma entre as várias denominações que, não sem polêmica, são dadas às atividades que o professor realiza depois de seu curso de graduação, conhecido como formação inicial). Nosso ponto de partida foi o estudo e a análise do depoimento de uma professora de Matemática que nos relata suas experiências de participação em cursos, seminários, workshops, e outros momentos de formação permanente, na qual estava ou esteve envolvida. Finalizamos, cotejando elementos surgidos nessa trama interpretativa com aqueles presentes na literatura atual sobre formação de professores de Matemática. Palavras-chave: Formação Permanente de Professores. Educação Matemática. Fenomenologia.

Marco Antonio Modesto

2007-01-01

112

The Educational Status of Federally Recognized Indian Students Enrolled in or Eligible for Enrollment in BIA and BIA Contract Schools, and Schools Receiving Support VIA the Johnson-O'Malley Act.  

Science.gov (United States)

Educational status of Indian students was found to be inferior to status of non-Indian students when measured by enrollment, attendance, dropout rate, and nonenrollment. The study found that Indian student enrollment had increased 2.3% from 1983 to 1984; average daily attendance was 4% less than for non-Indian students; dropout rates for Indian…

Latham, Glenn I.

113

25 CFR 170.807 - What must BIA include when it develops an IRR Transportation Facilities Maintenance Management...  

Science.gov (United States)

...Transportation Facilities Maintenance Management System? 170.807 Section 170...Transportation Facilities Maintenance Management System? (a) At a minimum, an...Information from other IRR Program management systems; (5) Future needs;...

2010-04-01

114

Phase angle from BIA as a prognostic and nutritional status tool for children and adolescents undergoing hematopoietic stem cell transplantation.  

UK PubMed Central (United Kingdom)

BACKGROUND & AIMS: The phase angle (PA) has been considered a prognostic and nutritional status indicator in several clinical situations considering its use as a body cell mass estimate value. The aim of this study was to evaluate the association between PA and other methods of nutritional assessment, as well as its prognostic value for children and adolescents undergoing hematopoietic stem cell transplantation (HSCT). METHODS: The nutritional status of 67 patients and 35 controls was assessed by bioelectric impedance analysis and anthropometric measurements. The phase angle was calculated and expressed in degrees and standardized (SPA) according to reference values. The Kaplan-Meier method was used to calculate survival and Kappa coefficient to determine the concordance between the SPA and other parameters of nutritional assessment. The correlation was established by using Pearson's correlation analysis. RESULTS: SPA progressively decreased during the treatment. The agreement between SPA and the diagnosis of malnutrition was moderate to %ideal weight, %TSF and %AMC and weak for BMI and weight/age z-score. Patients who had severe weight loss after transplantation had lower levels of SPA as compared to the group that did not lose weight (p < 0.001). Patients who developed chronic graft-versus-host disease had lower levels of SPA (p = 0.02), as well as patients who had been using corticosteroids during the post-transplant phase (p = 0.03). In this case, there was an inverse correlation between drug dose and SPA (p = 0.01). Patients with SPA ? 0 SD had a lower survival time as compared to the group of patients with SPA > 0 SD (p = 0.02) and showed an increased risk of death of 5.1as compared to the other group (95% CI: 1.41-18.94). CONCLUSION: The present study suggests that SPA could be useful as an indicator of survival and nutritional status for patients undergoing HSCT.

Farias CL; Campos DJ; Bonfin CM; Vilela RM

2013-06-01

115

Joanna Maj, Zdzis?aw Wo?niak, Rafa? Bia?ynicki-Birula, Alina Jankowska-Konsur  

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Full Text Available Wprowadzenie: Ziarniniak grzybiasty (mycosis fungoides, MF) jest najcz??ciej spotykanym pierwotnie skórnym ch?oniakiem T-komórkowym. We wczesnych stadiach charakteryzuje si? powolnym przebiegiem i obrazem klinicznym mog?cym przypomina? inne jednostki chorobowe. Przy?uszczyca plackowata wielkoogniskowa (parapsoriasis en grandes plaques, PP) nale??ca do skórnych rozrostów limfoproliferacyjnych T-komórkowych mo?e by? jednostk? chorobow? trudn? do ró?nicowania z wczesnymi postaciami MF. Cel pracy: Celem pracy by?a ocena ekspresji markerów proliferacji w populacjach komórek limfoidalnych wykwitów skórnych w przebiegu PP i MF. Materia? i metody: W badaniu wykorzystano bioptaty skórne pobrane od 11 chorych ze zdiagnozowan? PP, 23 chorych z wczesn? postaci? MF (stadium IA-IIA) oraz 22 pacjentów z zaawansowan? postaci? MF (IIB-IV). W badaniach immunohistochemicznych okre?lono poziom proliferacji komórkowej ocenia¬j?c ekspresj? Ki-67 i AgNORs. Analiz? statystyczn? przeprowadzono przy u?yciu testu t-Studenta. Wyniki: Nie stwierdzono statystycznie istotnych ró?nic (p>0,005) poziomu proliferacji komórkowej mierzonej obydwoma metodami mi?dzy grup? pacjentów z PP a grup? chorych z wczesn? postaci? MF. Wykazano natomiast statystycznie znacz?ce ró?nice dotycz?ce poziomu proliferacji komórkowej mi?dzy grup? z zaawansowanym MF a grup? z wczesn? postaci? MF i grup? z PP (p<0,005) w badaniach przeprowadzonych przy u?yciu obu markerów - Ki-67 i AgNORs. Wnioski: Badane czynniki Ki-67 i AgNORs s? u?ytecznymi markerami okre?laj?cymi rokowanie i stopie? zaawansowania MF. ?aden z nich nie umo?liwia ró?nicowania PP z wczesn? postaci? MF.

Joanna Maj; Zdzis?aw Wo?niak; Rafa? Bia?ynicki-Birula; Alina Jankowska-Konsur

2008-01-01

116

25 CFR 162.209 - When can BIA grant an agricultural lease on behalf of an Indian landowner?  

Science.gov (United States)

...an Indian landowner? (a) We may grant an agricultural lease on behalf of: (1) Individuals who are found to be non compos mentis by a court of competent jurisdiction; (2) Orphaned minors; (3) The undetermined heirs and devisees of...

2009-04-01

117

25 CFR 166.205 - When can the BIA grant a permit on behalf of Indian landowners?  

Science.gov (United States)

...behalf of Indian landowners? (a) We may grant a permit on behalf of: (1) An individual who is adjudicated to be non compos mentis by a court of competent jurisdiction; (2) An orphaned minor; (3) An Indian landowner who has granted us...

2009-04-01

118

Políticas Nacionales y Desarrollo Tecnológico en el sector del VIS. La calidad de Oferta VIS en Colom bia  

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Full Text Available Este documento presenta reflexiones que buscan articular y estructurar, en una visión de conjunto, observaciones que, acerca de la dimensión tecnológica de la actividad en el Sector de la Vivienda de Interés Social (VIS), se pueden sintetizar en estos hechos relevantes:

Fique Pinto Luis Fernando

2011-01-01

119

78 FR 45266 - Notice of Intent To Prepare a Resource Management Plan for the Oklahoma, Kansas, and Texas...  

Science.gov (United States)

...will also analyze Bureau of Indian Affairs (BIA) management decisions for lands and minerals managed by the BIA in the three states. DATES: This notice...Indian mineral interests administered by the BIA Eastern Oklahoma and Southern Plains...

2013-07-26

120

78 FR 15039 - Extending Scoping Period To Prepare a Programmatic Environmental Impact Statement (EIS) for the...  

Science.gov (United States)

...SUMMARY: The Bureau of Indian Affairs (BIA) is extending the public scoping period to prepare...928) 283-2210; email: renee.benally@bia.gov. SUPPLEMENTARY INFORMATION: The BIA published a Notice of Intent in the Federal...

2013-03-08

 
 
 
 
121

78 FR 2685 - Notice of Intent To Prepare a Programmatic Environmental Impact Statement (EIS) for the Navajo...  

Science.gov (United States)

...public that the Bureau of Indian Affairs (BIA) as lead Agency, with the Navajo Nation...283-2210; email: renee.benally@bia.gov. FOR FURTHER INFORMATION CONTACT...283-2210; email: renee.benally@bia.gov. SUPPLEMENTARY INFORMATION:...

2013-01-14

122

76 FR 43702 - Renewal of Agency Information Collection for Tribal Probate Codes  

Science.gov (United States)

...SUMMARY: The Bureau of Indian Affairs (BIA) is proposing to submit the information...Affairs, Director, Special Projects, BIA Division of Probate Services, 2600 N Central...AZ 85004; e-mail: Charlene.Toldeo@bia.gov. FOR FURTHER INFORMATION...

2011-07-21

123

Body Composition Tests  

Science.gov (United States)

... ARE BODY COMPOSITION TESTS? ANTHROPOMETRY BIOELECTRICAL IMPEDANCE ANALYSIS (BIA) BODY MASS INDEX (BMI) COMPUTERIZED TOMOGRAPHY (CT OR ... associated with greater health risk. Bioelectrical Impedance Analysis (BIA) In BIA, a person is weighed. Age, height, ...

124

76 FR 43702 - Renewal of Agency Information Collection for Probate of Indian Estates  

Science.gov (United States)

...SUMMARY: The Bureau of Indian Affairs (BIA) is proposing to submit the information...Affairs, Director, Special Projects, BIA Division of Probate Services, 2600 N Central...AZ 85004; e-mail: Charlene.Toldeo@bia.gov. FOR FURTHER INFORMATION...

2011-07-21

125

78 FR 7804 - Privacy Act of 1974; as amended; Notice to Amend an Existing System of Records  

Science.gov (United States)

...Management System (NIIMS), Interior, BIA-34,'' to update the system location...or emailing comments to Willie.Chism@bia.gov. FOR FURTHER INFORMATION CONTACT...Background The Bureau of Indian Affairs (BIA) maintains the ``National...

2013-02-04

126

Education in the Bureau of Indian Affairs. Research and Evaluation Report Series No. 52.  

Science.gov (United States)

Providing tabular, graphic, and narrative data, this report on American Indian education programs within the Bureau of Indian Affairs (BIA) details past, present, and future BIA educational concerns. Specifically, this report addresses: the BIA background; the contemporary scope of BIA education (Federal school operations, higher education and…

Benham, William J., Jr.

127

Assessment of body composition using dry mass index and ratio of total body water to estimated volume based on bioelectrical impedance analysis in chronic kidney disease patients.  

UK PubMed Central (United Kingdom)

OBJECTIVE: Body mass index (BMI) is commonly used for assessment of nutritional status. However, changes in BMI in chronic kidney disease (CKD) patients are affected not only by muscle and fat but also by fluid volume. The ratio of extracellular water (ECW(BIA)) to total body water (TBW(BIA)) in multifrequency bioelectrical impedance analysis is commonly used for assessing abnormal fluid status. This study reexamines ECW(BIA)/TBW(BIA) and evaluates the reliability of TBW(BIA)/TBW(watson) and dry mass index (DMI) in the assessment of fluid and nutritional status. DESIGN, SETTING, AND SUBJECTS: TBW(BIA), intracellular water (ICW(BIA)), and ECW(BIA) were measured in 45 randomly selected CKD patients. Participants were surveyed for age, gender, BMI, blood pressure, serum albumin, estimated glomerular filtration rate, and proteinuria. DMI was calculated by the formula ([weight--TBW(BIA)]/height(2)) and TBW(BIA)/TBW(watson) using an anthropometric formula (Watson). Fluid and nutritional status were assessed using ECW(BIA)/TBW(BIA), TBW(BIA)/TBW(watson), and DMI. RESULTS: TBW(BIA)/TBW(watson) positively correlated with weight, BMI, and diastolic blood pressure and negatively correlated with age and serum albumin level. In contrast, ECW(BIA)/TBW(BIA) correlated with ICW deficit, aging, and body weight loss. On the basis of DMI and TBW(BIA)/TBW(watson), participants were categorized as follows: 1 obese patient with hypovolemia and 2 with euvolemia; 17 overweight patients with hypovolemia (n = 6), euvolemia (n = 8), or hypervolemia (n = 3); 24 patients of optimal weight with hypovolemia (n = 10), euvolemia (n = 9), or hypervolemia (n = 5); and 1 underweight patient with euvolemia. CONCLUSIONS: A combination of DMI, BMI, and TBW(BIA)/TBW(watson) makes it possible to include assessment of fluid volume to the physique index. In addition, ECW(BIA)/TBW(BIA) is not a reliable marker of edematous state in CKD patients.

Ohashi Y; Otani T; Tai R; Tanaka Y; Sakai K; Aikawa A

2013-01-01

128

Apophyllite from the Mi?dzyrzecze sillnear Bielsko-Bia?a, the type of area of the teschenite-picrite association  

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Full Text Available Fluorapophyllite crystals from complex veins crosscutting a small pectolite skarn bodyat the top of the Miêdzyrzecze sill were studied by means of chemical analysis, X-ray diffraction, thermalanalysis and both infrared and Raman spectroscopy. The apophyllite from Miêdzyrzecze, lacking abnormaloptical properties, is tetragonal with lattice parameters: a = 8.974(2) Å, c = 15.798(6) Å. DTA curves exhibittwo endothermic peaks centred at about 330 and 430C. The dehydration behaviour of apophyllite resultsfrom the development on the outer parts of grains of an amorphous layer. It forms a diffusion barrier thatmoderates H2O migration and originates in the second endothermic peak. IR investigations showed a newstretching vibration (OH), not previously recognized in apophyllite. This new band at 3627 cm–1 can beattributed to (OH) of the hydroxyl group which substitutes for F– in the apophyllite structure. Selectiveleaching of phlogopite probably released the elements necessary for apophyllite precipitation in open spacesof the fissures in the upper part of the picrite sill.

Roman W?odyka; Roman Wrzalik

2004-01-01

129

Ekspresja bia?ek Id1, epidermalnego czynnika wzrostu (EGF) i jego receptora (EGF-R) w nowotworach z?o?liwych jajnika  

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Full Text Available Introduction: Inhibitors of DNA binding/inhibitors of differentiation (Id) protein family (Id1, Id2, Id3 and Id4)may play an important role in various cancer angiogenesis stimulation through interactions with strongmitogenic and angiogenic factors such as EGF and EGFR.Aim of the study: Our aim was to assess if the expression of Id1 protein with EGF and EGF-R serumconcentration assessment is associated with selected epidemiological, clinical and histological features ofmalignant ovarian tumours.Material and methods: The study group included 95 women operated because of ovarian tumours. In thisgroup, 83 masses proved to be malignant. The findings were correlated with the tumour type, histologicalgrading and tumour FIGO stage. Tumour Id1 protein was assessed by immunohistochemistry and EGF with EGF-Rserum concentrations were examined by ELISA.Results: The mean age of the patients was 52.6 ±15.1 years and 43 (45.2%) of women in this group werepremenopausal. Histological examination revealed that in the malignant group there were 38 serous ovariancancers, 23 mucinous cancers, 7 endometrioid cancers and 13 other malignant tumours including 6 metastaticto the ovary. Significant differences were found between concentrations of EGF and EGF-R depending on thepatient's menopausal status (p = 0.01 and p = 0.002, respectively). Histological grade was significantlycorrelated with EGF concentrations in women with malignant ovarian tumours (p = 0.01). FIGO stage was alsosignificantly correlated with Id1 expression (p = 0.09) and EGF concentration (p = 0.01). Also, significantcorrelations were found between Id1 expression, and histological grade and tumour FIGO stage (both p = 0.005). EGF and EGF-R concentrations were significantly correlated with each other (p = 0.008). Moreover, both EGF andEGF-R concentrations were correlated with Id1 expression (p = 0.0005 and p = 0.004, respectively).Conclusion: Our results indicate that Id1 protein and EGF with EGF-R concentration assessment may beused as additional prognostic markers in women with various types of malignant ovarian tumours.

Artur Czekierdowski; Sylwia Czekierdowska; Jaros?aw Dani?o?; Andrzej Nowakowski; Norbert Stachowicz

2010-01-01

130

G?ówne bia?ko zasadowe eozynofilów (eosinophil major basic protein - MBP) a przeciwcia?a IgA przeciwko naskórkowej transglutaminazie w opryszczkowatym zapaleniu skóry  

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Full Text Available Wst?p: W opryszczkowatym zapaleniu skóry (dermatitis herpetiformis - DH) w szczytach brodawek skórnych wyst?puj? mikroropnie z?o?one g?ównie z neutrofilów. Neutrofilom przypisuje si? istotn? rol? w niszczeniu po??czenia skórno-naskórkowego. Poniewa? eozynofile tak?e s? tam obecne, wi?c nie mo?na wykluczyæ ich udzia?u w patogenezie zmian skórnych. Cel pracy: Celem pracy by?a numeryczna analiza nasilenia skórnych z?ogów MBP u pacjentów z DH w porównaniu z chorymi z pemfigoidem p?cherzowym (bullous pemphigoid - BP) oraz zbadanie korelacji mi?dzy poziomem przeciwcia? kr???cych IgA przeciwko naskórkowej transglutaminazie (IgA eTG) a nasileniem skórnych z?ogów MBP w DH. Materia? i metody: Badaniami obj?to 18 chorych na DH i 15 na BP. MBP w skórze obejmuj?cej ?wie?y p?cherz wykrywano technik? immuno-histochemiczn? streptawidyna/peroksydaza. Nasilenie z?ogów MBP analizowano numerycznie w p?aszczy?nie i w przestrzeni przy u?yciu programu komputerowego Analizator 4D. Poziom surowiczych przeciwcia? IgA eTG badano technik? ELISA. Wyniki: Nasilenie z?ogów MBP w grupie BP analizowane zarówno w p?aszczy?nie, jak i przestrzennie by?o znamiennie wy?sze od nasilenia z?ogów wDH. Nie stwierdzono znamiennej zale?no?ci mi?dzy poziomem kr???cych przeciwcia? IgA eTG a nasileniem skórnych z?ogów MBP w DH. Wnioski: Wydaje si?, ?e pobudzenie eozynofilów skórnych w DH oceniane uwalnianiem MBP jest mniej intensywne od pobudzenia eozynofilów skórnych w BP. Kr???ce przeciwcia?a IgA eTG nie wp?ywaj? znacz?co na uwalnianie MBP w DH.

Gra?yna Wolnik-Trzeciak; Monika Bowszyc-Dmochowska; Agnieszka Górna; Edyta Nieruchalska; El?bieta Kaczmarek; Marian Dmochowski

2005-01-01

131

Report on the soil-zoological expeditions to Ecuador and Colom­bia between 1986-1993. I. list of localities and habitats of "Berlese" samples.  

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Full Text Available Complete lists of the sampling localities and habitats of the Hungarian soil zoological expeditions to Ecuador and Colombia between 1986 and 1993 are presented. The lists are organized according to the expedition’s dates and apart from the locality some data on the biotopes and sampled substrates are also given.

Zicsi, A.

2008-01-01

132

Indian Issues: BIA's Efforts to Impose Time Frames and Collect Better Data Should Improve the Processing of Land in Trust Applications.  

Science.gov (United States)

In 1980, the Department of the Interior (Interior) established regulations to provide a uniform approach for taking land in trust. Trust status means the government holds title to the land in trust for tribes and individual Indians. Trust land is exempt f...

2006-01-01

133

Effects of site-directed mutations on heme reduction in Escherichia coli nitrate reductase A by menaquinol: a stopped-flow study.  

Science.gov (United States)

We have studied the effects of site-directed mutations in Escherichia coli nitrate reductase A (NarGHI) on heme reduction by a menaquinol analogue (menadiol) using the stopped-flow method. For NarGHI(H66Y) and NarGHI(H187Y), both lacking heme b(L) but having heme b(H), the heme reduction by menadiol is abolished. For NarGHI(H56R) and NarGHI(H205Y), both without heme b(H) but with heme b(L), a smaller and slower heme reduction compared to that of the wild-type enzyme is observed. These results indicate that electrons from menadiol oxidation are transferred initially to heme b(L). A transient species, likely to be associated with a semiquinone radical anion, was generated not only on reduction of the wild-type enzyme as observed previously (1) but also on reduction of NarGHI(H56R) and NarGHI(H205Y). The inhibitors 2-n-heptyl-4-hydroxyquinoline-N-oxide and stigmatellin both have significant effects on the reduction kinetics of NarGHI(H56R) and NarGHI(H205Y). We have also investigated the reoxidation of menadiol-reduced heme by nitrate in the mutants. Compared to the wild type, no significant heme reoxidation is observed for NarGHI(H56R) and NarGHI(H205Y). This result indicates that a single mutation removing heme b(H) blocks the electron-transfer pathway from the subunit NarI to the catalytic dimer NarGH. PMID:14640690

Zhao, Zhongwei; Rothery, Richard A; Weiner, Joel H

2003-12-01

134

Draft Genome Sequences of Five Strains of Lactobacillus acidophilus, Strain CIP 76.13T, Isolated from Humans, Strains CIRM-BIA 442 and CIRM-BIA 445, Isolated from Dairy Products, and Strains DSM 20242 and DSM 9126 of Unknown Origin.  

Science.gov (United States)

Lactobacillus acidophilus is a natural inhabitant of mammalian gastrointestinal systems and is used in dairy and pharmaceutical products. Five draft genome sequences, covering 1,995,790 nucleotides (nt) on average, are divided into 19 to 34 scaffolds covering 1,995 to 2,053 genes. The draft genome sequences were compared to the sequence of the L. acidophilus NCFM dairy strain. PMID:23969059

Falentin, Hélène; Cousin, Sylvie; Clermont, Dominique; Creno, Sophie; Ma, Laurence; Chuat, Victoria; Loux, Valentin; Rüdiger, Pukall; Bizet, Chantal; Bouchier, Christiane

2013-08-22

135

Draft Genome Sequences of Five Strains of Lactobacillus acidophilus, Strain CIP 76.13T, Isolated from Humans, Strains CIRM-BIA 442 and CIRM-BIA 445, Isolated from Dairy Products, and Strains DSM 20242 and DSM 9126 of Unknown Origin.  

UK PubMed Central (United Kingdom)

Lactobacillus acidophilus is a natural inhabitant of mammalian gastrointestinal systems and is used in dairy and pharmaceutical products. Five draft genome sequences, covering 1,995,790 nucleotides (nt) on average, are divided into 19 to 34 scaffolds covering 1,995 to 2,053 genes. The draft genome sequences were compared to the sequence of the L. acidophilus NCFM dairy strain.

Falentin H; Cousin S; Clermont D; Creno S; Ma L; Chuat V; Loux V; Rüdiger P; Bizet C; Bouchier C

2013-01-01

136

78 FR 23782 - Renewal of Agency Information Collection for Appointed Counsel in Involuntary Indian Child...  

Science.gov (United States)

...of 1995, the Bureau of Indian Affairs (BIA) is seeking comments on the renewal of...208-2648, or email: Sue.Settles@bia.gov. FOR FURTHER INFORMATION CONTACT...Abstract The Bureau of Indian Affairs (BIA) is seeking comments on the...

2013-04-22

137

78 FR 49120 - Courts of Indian Offenses  

Science.gov (United States)

...Bureau of Indian Affairs 25 CFR Part 11 [BIA-2013-0001; 134/A0J351010.999900...SUMMARY: The Bureau of Indian Affairs (BIA) is confirming the interim final rule published...March 3, 2013, publication stated that the BIA would review comments on the interim...

2013-08-13

138

78 FR 32273 - Renewal of Agency Information Collection for Navajo Partitioned Lands Grazing Permits  

Science.gov (United States)

...of 1995, the Bureau of Indian Affairs (BIA) is seeking comments on the renewal of...219-0006; email: David.Edington@bia.gov. FOR FURTHER INFORMATION CONTACT...SUPPLEMENTARY INFORMATION: I. Abstract BIA is seeking renewal of the approval for...

2013-05-29

139

78 FR 15040 - Extending the Review Period for the Final Environmental Impact Statement (FEIS) for the Proposed...  

Science.gov (United States)

...SUMMARY: The Bureau of Indian Affairs (BIA) is extending the review period for the...related to the FEIS must be received by the BIA by May 1, 2013. The Record of Decision...231-6749. SUPPLEMENTARY INFORMATION: The BIA published a Notice of Availability for...

2013-03-08

140

78 FR 15036 - Renewal of Agency Information Collection for Navajo Partitioned Lands Grazing Permits  

Science.gov (United States)

...of 1995, the Bureau of Indian Affairs (BIA) is seeking comments on the renewal of...219-0006; email: David.Edington@bia.gov. FOR FURTHER INFORMATION CONTACT...SUPPLEMENTARY INFORMATION: I. Abstract BIA is seeking renewal of the approval for...

2013-03-08

 
 
 
 
141

78 FR 4164 - Draft Environmental Impact Statement for the Proposed Point Molate Resort and Casino for the...  

Science.gov (United States)

...announces that the Bureau of Indian Affairs (BIA), as lead agency, intends to cancel all...Environmental Impact Statement (EIS) for the BIA Federal action of approving the fee-to...95825. SUPPLEMENTARY INFORMATION: The BIA is canceling work on the EIS because...

2013-01-18

142

77 FR 60041 - Heating, Cooling, and Lighting Standards for Bureau-Funded Dormitory Facilities  

Science.gov (United States)

...Indian Affairs 25 CFR Part 36 [Docket ID BIA-2012-0001] RIN 1076-AF10 Heating...SUMMARY: The Bureau of Indian Affairs (BIA) is confirming the interim final rule published...24, 2012, publication stated that the BIA would review comments on the interim...

2012-10-02

143

78 FR 49990 - Land Acquisitions: Appeals of Land Acquisition Decisions  

Science.gov (United States)

...134D0102DR-DS5A300000-DR.5A311.IA000113; Docket ID: BIA-2013-0005] RIN 1076-AF15 Land Acquisitions...In May, the Bureau of Indian Affairs (BIA) published a proposed rule revising a section...The rule has been assigned Docket ID: BIA-2013-0005. --Email:...

2013-08-16

144

78 FR 15035 - Extension, Without Changes of Agency Information Collection for Indian Self-Determination and...  

Science.gov (United States)

...projects, the Bureau of Indian Affairs (BIA) and the Indian Health Service (IHS...cooperative agreements (contracts) for award by BIA and IHS, as authorized by the Indian Self-Determination...You may submit comments regarding the BIA information collection activities...

2013-03-08

145

78 FR 32272 - Renewal of Agency Information Collection for Indian Self-Determination and Education Assistance...  

Science.gov (United States)

...of 1995, the Bureau of Indian Affairs (BIA) is submitting to the Office of Management...Chief, Division of Self-Determination, BIA Office of Indian Services, 1849 C Street...or send via email to Terrence.Parks@bia.gov. FOR FURTHER INFORMATION...

2013-05-29

146

76 FR 30961 - Renewal of Agency Information Collection for Certificate of Degree of Indian or Alaska Native...  

Science.gov (United States)

...of 1995, the Bureau of Indian Affairs (BIA) is seeking comments on renewal of the...Washington, DC 20240; Kevin.bearquiver@bia.gov. FOR FURTHER INFORMATION CONTACT...SUPPLEMENTARY INFORMATION: I. Abstract BIA is seeking renewal of the approval for...

2011-05-27

147

78 FR 4164 - Renewal of Agency Information Collection for Appointed Counsel in Involuntary Indian Child...  

Science.gov (United States)

...of 1995, the Bureau of Indian Affairs (BIA) is seeking comments on the renewal of...208-5113; email: Linda.Ketcher@bia.gov. FOR FURTHER INFORMATION CONTACT...Abstract The Bureau of Indian Affairs (BIA) is seeking comments on the...

2013-01-18

148

77 FR 60139 - Draft Environmental Impact Statement for the Proposed Pueblo of Jemez 70.277-Acre Fee-to-Trust...  

Science.gov (United States)

...announces that the Bureau of Indian Affairs (BIA) as lead agency, in cooperation with the...Environmental Impact Statement (EIS) for the BIA Federal action of approving a 70.277 acre...87104. SUPPLEMENTARY INFORMATION: The BIA is canceling work on the EIS because...

2012-10-02

149

75 FR 8731 - Renewal of Agency Information Collection for Grazing Permits  

Science.gov (United States)

...SUMMARY: The Bureau of Indian Affairs (BIA) is seeking comments on renewal of Office...submit certain information for review by the BIA. DATES: Interested persons are invited...219-0006, or e-mail David.Edington@bia.gov. FOR FURTHER INFORMATION...

2010-02-25

150

77 FR 58860 - Renewal of Agency Information Collection for the Tribal Reassumption of Jurisdiction Over Child...  

Science.gov (United States)

...of 1995, the Bureau of Indian Affairs (BIA) is submitting to the Office of Management...208-2648, or email: Sue.Settles@bia.gov. FOR FURTHER INFORMATION CONTACT...C. 1918. II. Request for Comments The BIA requests your comments on this...

2012-09-24

151

76 FR 6493 - Notice of Intent to Prepare an Environmental Impact Statement for the Proposed K Road/Moapa Band...  

Science.gov (United States)

...public that the Bureau of Indian Affairs (BIA), as lead agency, with the Moapa Band...Regional Environmental Protection Officer, BIA Western Regional Office Branch of Environmental...379-3833; e-mail: amy.heuslein@bia.gov; or Mr. Paul Schlafly,...

2011-02-04

152

78 FR 37164 - Land Acquisitions: Appeals of Land Acquisition Decisions  

Science.gov (United States)

...134D0102DR-DS5A300000-DR.5A311.IA000113; Docket ID: BIA-2013-0005] RIN 1076-AF15 Land Acquisitions...SUMMARY: The Bureau of Indian Affairs (BIA) published a proposed rule in the Federal...202) 273-4680; elizabeth.appel@bia.gov. SUPPLEMENTARY INFORMATION:...

2013-06-20

153

78 FR 7448 - Final Environmental Impact Statement for the Proposed Spokane Tribe of Indians West Plains Casino...  

Science.gov (United States)

...public that the Bureau of Indian Affairs (BIA) as lead agency, with the Spokane Tribe...indirect and growth inducing effects. The BIA serves as the Lead Agency for compliance...Environmental Policy Act (NEPA). The BIA has afforded other government agencies...

2013-02-01

154

[STAT5B deficiency: a new growth hormone insensitivity syndrome associated to immunological dysfunction].  

UK PubMed Central (United Kingdom)

A new presentation of growth hormone insensitivity (GHI) caused by homozygous mutations in STAT5B (signal transducer and activator of transcription 5B) gene has been characterized in the last years. Its particularity is the association with severe immune dysfunction, especially with lymphocytic interstitial pneumonitis. This may mislead physicians into considering short stature as secondary to chronic immunological disease and consequently into underdiagnosing this form of GHI. The objective of this review is to propagate current knowledge about this rare pathology, facilitating the diagnosis of patients with GHI due to STAT5B mutations in endocrinology and other specialties clinics.

Scalco RC; Pugliese-Pires PN; Jorge AA

2013-07-01

155

[STAT5B deficiency: a new growth hormone insensitivity syndrome associated to immunological dysfunction].  

Science.gov (United States)

A new presentation of growth hormone insensitivity (GHI) caused by homozygous mutations in STAT5B (signal transducer and activator of transcription 5B) gene has been characterized in the last years. Its particularity is the association with severe immune dysfunction, especially with lymphocytic interstitial pneumonitis. This may mislead physicians into considering short stature as secondary to chronic immunological disease and consequently into underdiagnosing this form of GHI. The objective of this review is to propagate current knowledge about this rare pathology, facilitating the diagnosis of patients with GHI due to STAT5B mutations in endocrinology and other specialties clinics. PMID:23896798

Scalco, Renata C; Pugliese-Pires, Patrícia N; Jorge, Alexander A L

2013-07-01

156

Periodontal status evaluation in patients with diagnosed IBD: Crohn's disease and ulcerative colitis Ocena stanu przyz?bia u pacjentów z rozpoznanym NZJ: chorob? Le?niowskiego-Crohna i wrzodziej?cym zapaleniem jelita grubego  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction: Non-specific inflammatory bowel diseases (IBD) and periodontitis are multifactorial diseases. The immune response plays a significant role in their onset and course. The aim of the study was to asses the periodontium in a group of patients diagnosed with non-specific IBD, including Crohn's disease and colitis ulcerosa (CU).Materials and methods: 75 patients hospitalized due to IBD were examined using a periodontal probeand a dental mirror; periodontal indexes including plaque index (PI) and bleeding on probing (BOP)pocket depths (PD) and clinical attachment loss (CAL) were measured. CAL was used for diagnosis of periodontitis. Additionally, the activity of a periodontal disease was assessed using the Offenbacher scale.Results: The average plaque index was 50.15%, average BOP 9.7%, average PD: 1.55 mm, average CAL: 0.45 mm. Chronic periodontitis was diagnosed in 96% of patients (72 individuals), of whom 27%had a generalized form of periodontitis, which occurred more often in the Crohn's disease group thanin the CU group. In 69% of patients a localized form was diagnosed. Three people were diagnosed ashealthy. The assessment of periodontium was performed with reference to gastroenterological diagnosis and applied immunotherapy.Conclusions: Periodontitis and gingivitis were more often present in the Crohn's disease group thanin the CU group. Compared to available research, the study group of patients demonstrated a higherplaque index but lower PD and BOP indexes.

Agata Gieorgijewska; Monika Adamczyk-Mo?cicka; Magdalena Pawlik; Jaros?aw Krajewski; Renata Górska; Gra?yna Rydzewska; Edward Franek

2011-01-01

157

Periodontal status evaluation in patients with diagnosed IBD: Crohn's disease and ulcerative colitis Ocena stanu przyz?bia u pacjentów z rozpoznanym NZJ: chorob? Le?niowskiego-Crohna i wrzodziej?cym zapaleniem jelita grubego  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Introduction: Non-specific inflammatory bowel diseases (IBD) and periodontitis are multifactorial diseases. The immune response plays a significant role in their onset and course. The aim of the study was to asses the periodontium in a group of patients diagnosed with non-specific IBD, including Cro...

Agata Gieorgijewska; Monika Adamczyk-Mo?cicka; Magdalena Pawlik; Jaros?aw Krajewski; Renata Górska; Gra?yna Rydzewska

158

Comparing physical properties of aminoglycoside antibiotics' binding sites in RNA and proteins Analiza porównawcza w?asno?ci fizycznych miejsc wi?zania antybiotyków aminoglikozydowych w RNA i bia?kach  

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Aminoglycoside antibiotics have been in use for more than 60 years, helping combat severe bacterial infections. Due to this long time of usage, more and more bacteria become resistant to one or several drugs from this group. This spread of resistant species is alarming and additionally, there is lit...

Romanowska, Julia

159

IgA antibodies against fusion protein containing modified nonapeptide of gliadin in dermatitis herpetiformis. Przeciwcia?a IgA przeciwko bia?ku fuzyjnemu zawieraj?cemu zmodyfikowany nonapeptyd gliadyny w opryszczkowatym zapaleniu skóry.  

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Full Text Available Introduction: Dermatitis herpetiformis (DH) is a chronic, intensely itchy, blistering skin manifestation of gluten sensitive enteropathy, commonly known as celiac disease. Epidermal transglutaminase and closely related tissue transglutaminase are considered to be autoantigens in DH. Direct immunofluorescence test (DIF) of nonlesional skin remains definitive laboratory test for diagnosing this disease. Aim of the study: The aim of this work was to assess the level of serum IgA antibodies to fusion modified protein containing nonapeptide of gliadin in patients with DH and evaluate usefulness of ELISA measuring those antibodies in dealing with DH patients. Material and methods: Sera from 26 patients with DH were examined. All patients had typical IgA deposits detected with DIF. IgA antibodies against fusion protein containing modified nonapeptide of gliadin were detected using ELISA. Epicutaneous patch tests were also performed in 9 of 26 DH patients. Results: IgA antibodies against fusion protein containing nonapeptide of gliadin were found in 85% of DH sera. At blood taking 92% of patients had cutaneous lesions, 32% had intestinal symptoms, 9% had been on a gluten-free diet, and 14% were treated with dapsone. The male to female ratio was 1.36:1. None of tested patients was allergic to nickel. Conclusions: Our data suggests that testing for IgA antibodies to fusion protein containing modified nonapeptide of gliadin is a useful adjunct in diagnosing DH.

Justyna Gornowicz; Monika Bowszyc-Dmochowska; Marian Dmochowski

2010-01-01

160

Przypuszczalna rola bia?ka CagA w hamowaniu aktywno?ci limfocytów na drodze apoptozy w zaka?eniach wywo?anych przez pa?eczki Helicobacter pylori  

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Full Text Available Poprzednio sugerowano, ?e produkty genów cagA i vacA Helicobacter pylori mog? stymulowa? lub hamowa? proliferacj? limfocytów T zdrowych dawców niewytwarzaj?cych przeciwcia? przeciwko H. pylori. Obecnie potwierdzono przeciwproliferacyjne dzia?anie CagA, wykazuj?c ca?kowite hamowanie transformacji komórek T w obecno?ci fitohemaglutyniny (PHA) przez frakcj? cytoplazmatyczn? (CF) rodzicielskiego szczepu H. pylori G27 CagA+VacA+ i brak wp?ywu na odpowied? blastyczn? CF izogenicznego mutanta H. pylori G27 CagA-VacA+. W komórkach hodowanych w obecno?ci CF szczepów H. pylori CagA+ wykazano wczesne, odwracalne zmiany apoptotyczne. Immunosupresyjne dzia?anie CagA H. pylori mo?e by? przyczyn? przewlek?ych zaka?e? wywo?ywanych przez te bakterie.

Beata Paziak-Doma?ska; Magdalena Chmiela; Agnieszka Jarosi?ska; Lech Pokoca; Krzysztof Zeman; Wies?awa Rudnicka

2000-01-01

 
 
 
 
161

Growth is a remarkable and multifaceted biological ...  

Science.gov (United States)

Text Version... factor 1; GHR, growth hormone receptor; GHBP, growth hormone binding protein; GHI, growth hormone insensitivity; GHRE, GATA.l hormone ... More results from www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation

162

No apparent progress in bioelectrical impedance accuracy: validation against metabolic risk and DXA.  

Science.gov (United States)

Bioelectrical impedance (BIA) is quick, easy, and safe when quantifying fat and lean tissue. New BIA models (Tanita BC-418 MA, abbreviated BIA(8)) can perform segmental body composition analysis, e.g., estimate %trunkal fatness (%TF). It is not known, however, whether new BIA models can detect metabolic risk factors (MRFs) better than older models (Tanita TBF-300, abbreviated BIA(4)). We therefore tested the correlation between MRF and percentage whole-body fat (%BF) from BIA(4) and BIA(8) and compared these with the correlation between MRF and dual-energy X-ray absorptiometry (DXA, used as gold standard), BMI and waist circumference (WC). The sample consisted of 136 abdominally obese (WC >or= 88 cm), middle-aged (30-60 years) women. MRF included fasting blood glucose and insulin; high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides; high sensitive C-reactive protein, plasminogen activator inhibitor-1 (PAI-1), and fibrinogen; and alanine transaminase (ALT) liver enzyme. We found that similar to DXA, but in contrast to BMI, neither %BF BIA(4) nor %BF BIA(8) correlated with blood lipids or ALT. In the segmental analysis of %TF, BIA(8) only correlated with inflammatory markers, but not insulin, blood lipids, or ALT liver enzyme (in contrast to WC and %TF DXA). %TF DXA was associated with homeostatic model assessment insulin resistance (HOMA-IR) independently of WC (P = 0.03), whereas %TF BIA(8) was not (P = 0.53). Receiver-operating characteristic (ROC) curves confirmed that %TF BIA(8) did not differ from chance in the detection of insulin resistance (P = 0.26). BIA estimates of fatness were, at best, weakly correlated with obesity-related risk factors in abdominally obese women, even the new eight-electrode model. Our data support the continued use of WC and BMI. PMID:18997678

Hemmingsson, Erik; Uddén, Joanna; Neovius, Martin

2008-11-06

163

No apparent progress in bioelectrical impedance accuracy: validation against metabolic risk and DXA.  

UK PubMed Central (United Kingdom)

Bioelectrical impedance (BIA) is quick, easy, and safe when quantifying fat and lean tissue. New BIA models (Tanita BC-418 MA, abbreviated BIA(8)) can perform segmental body composition analysis, e.g., estimate %trunkal fatness (%TF). It is not known, however, whether new BIA models can detect metabolic risk factors (MRFs) better than older models (Tanita TBF-300, abbreviated BIA(4)). We therefore tested the correlation between MRF and percentage whole-body fat (%BF) from BIA(4) and BIA(8) and compared these with the correlation between MRF and dual-energy X-ray absorptiometry (DXA, used as gold standard), BMI and waist circumference (WC). The sample consisted of 136 abdominally obese (WC >or= 88 cm), middle-aged (30-60 years) women. MRF included fasting blood glucose and insulin; high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides; high sensitive C-reactive protein, plasminogen activator inhibitor-1 (PAI-1), and fibrinogen; and alanine transaminase (ALT) liver enzyme. We found that similar to DXA, but in contrast to BMI, neither %BF BIA(4) nor %BF BIA(8) correlated with blood lipids or ALT. In the segmental analysis of %TF, BIA(8) only correlated with inflammatory markers, but not insulin, blood lipids, or ALT liver enzyme (in contrast to WC and %TF DXA). %TF DXA was associated with homeostatic model assessment insulin resistance (HOMA-IR) independently of WC (P = 0.03), whereas %TF BIA(8) was not (P = 0.53). Receiver-operating characteristic (ROC) curves confirmed that %TF BIA(8) did not differ from chance in the detection of insulin resistance (P = 0.26). BIA estimates of fatness were, at best, weakly correlated with obesity-related risk factors in abdominally obese women, even the new eight-electrode model. Our data support the continued use of WC and BMI.

Hemmingsson E; Uddén J; Neovius M

2009-01-01

164

Validation of bioelectrical-impedance analysis as a measurement of change in body composition in obesity  

International Nuclear Information System (INIS)

[en] The bioelectrical-impedance-analysis (BIA) method accurately measures body composition in weight-stable subjects. This study validates the use of BIA to measure change in body composition. Twelve obese females underwent weight loss at a mean rate of 1.16 kg/wk. Body composition was measured by deuterium oxide dilution (D2O), BIA, and skinfold anthropometry (SFA) at baseline and at 5% decrements in weight. Highly significant correlations were obtained between D2O and BIA (r = 0.971) and between D2O and SFA (r = 0.932). Overall, BIA predicted change in fat-free mass with greater accuracy (to 0.4 kg) and precision (+/- 1.28 kg) than did anthropometry (to 0.8 kg and +/- 2.58 kg, respectively). We conclude that BIA is a useful clinical method for measuring change in body composition

1990-01-01

165

25 CFR 170.806 - What is an IRR Transportation Facilities Maintenance Management System?  

Science.gov (United States)

...Transportation Facilities Maintenance Management System? 170.806 Section 170...Transportation Facilities Maintenance Management System? An IRR Transportation Facilities Maintenance Management System (TFMMS) is a tool BIA and...

2009-04-01

166

Obesity and Its Diagnostic Methods in Turkish Children  

Directory of Open Access Journals (Sweden)

Full Text Available Objective: The application of body mass index (BMI) for obesity classification in all population studies has been questioned by the scientific community. It has been found that the bioelectrical impedance analysis (BIA) is an accurate method for screening obesity. This study was conducted to evaluate the accuracies of BMI, skinfold thickness (SFT), leptin and BIA measurements in obesity classification and to find correlations between BIA and the other indicators for obesity. Materials and Methods: This case-control study included 178 children of whom 90 were in the obese group and 88 in the control group. The study measured BMI, SFT, leptin level and BIA-mediated body fat percentage (BIA BFP) in each child. Results: The BMIs, leptin levels, SFTs and BIA BFPs of children in the obese group were found to be higher than those in the control group (p<0.001). The measurement of BIA BFP strongly correlated with BMI, SFT and waist circumference, whereas BIA BFP measurement showed weak-moderate correlation with leptin level. Conclusion: Bioelectrical impedance analysis was found to be an accurate measure of BFP in obesity. In addition, BIA may prevent the incorrect diagnosis of obesity as determined by BMI alone, especially in boys during the pubertal period.

Dilek Yilmaz; Gulten Inan; Sacide Karakas; Aslihan Buyukozturk-Karul; Ferah Sonmez

2012-01-01

167

Early changes of abdominal adiposity detected with weekly dual bioelectrical impedance analysis during calorie restriction.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To elucidate early change of intra-abdominal fat in response to calorie restriction in patients with obesity by weekly evaluation using a dual bioelectrical impedance analysis (Dual BIA) instrument. RESEARCH DESIGN AND METHODS: For 67 Japanese patients with obesity, diabetes, or metabolic syndrome, intra-abdominal fat area (IAFA), initially with both Dual BIA and computed tomography (CT), and in subsequent weeks of calorie restriction, with Dual BIA were measured. RESULTS: IAFA by Dual BIA (Dual BIA-IAFA) correlated well with IAFA by CT (CT-IAFA) in obese patients (r = 0.821, P < .0001, n = 67). Ten males and 9 females (age 49.0 ± 14.4 years, BMI 33.2 ± 7.3 kg/m(2) ) lost more than 5% of baseline body weight (BW) in 3 weeks, and their Dual BIA-IAFA, BW, and WC decreased by 18.9%, 5.3%, and 3.8%, respectively (P < .05, ANCOVA). CONCLUSION: Dual BIA instrument could detect the weekly change of Dual BIA-IAFA under calorie restriction in obese patients and demonstrated a substantially larger change of IAFA compared with changes of BW and WC in early weeks. This observation corroborates the significance of evaluating IAFA as a biomarker for obesity, and indicates the clinical usefulness of the Dual BIA instrument.

Ida M; Hirata M; Odori S; Mori E; Kondo E; Fujikura J; Kusakabe T; Ebihara K; Hosoda K; Nakao K

2013-01-01

168

Evaluación de la composición corporal en niñas usando impedanciometría bioeléctrica y pliegues subcutáneos Assessment of body composition in girls by bioelectrical impedance and skinfold anthropometry  

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Full Text Available La estimación de los pliegues subcutáneos (PS) para evaluar composición corporal ha sido utilizada durante años, sin embargo, su uso tiene limitaciones. La impedanciometría bioeléctrica (BIA) es un nuevo método cuyo uso ha sido recomendado en adultos. Objetivos: evaluar si la BIA para estimar grasa corporal (GC) tiene una precisión comparable a la obtenida usando PS en pediatría. Material y métodos: Se determinó % GC usando las ecuaciones de Slaughter para PS y Deurenberg, Houtkooper, Schaefer y Cordain para BIA en 50 niñas, entre 9 y 11,6 años. Resultados: El nivel de concordancia, evaluado por el método de Bland y Altman, entre % GC derivado de las ecuaciones de BIA y PS, fue pobre, con una diferencia promedio de 5% ± 2DE (-5,5 a 15,5). Conclusiones: En la determinación de GC la BIA no arroja cifras concordantes con las obtenidas por PS, por lo cual no es adecuado recomendar su uso en pediatríaSkinfold anthropometry (SKF) has been used to estimate body composition for many years but it has several limitations. Bioelectrical impedance (BIA) is a new method recently recommended to be used in adults. Aim: To determine the level of agreement for body fat mass (BF) measurement by BIA and SKF. Subjects and methods: BF was calculated using the following algorithms: Slaughter for SKF, Deurenberg, Houtkooper, Schafer and Cordain for BIA in 50 girls aged between 9 and 11,6 years. Results: Level of agreement determined using Bland and Altman method was poor, with an average difference (SKF-BIA) of 5% ± 2 DS (-5.5 to 15.5). Conclusions: Measurements of BF determined by BIA gave poor agreement with SKF, thus the use of BIA is not recommended in pediatrics clinical practice

Pascuala Urrejola N.; María Isabel Hodgson B.; María Gloria Icaza N.

2001-01-01

169

Evaluación de la composición corporal en niñas usando impedanciometría bioeléctrica y pliegues subcutáneos/ Assessment of body composition in girls by bioelectrical impedance and skinfold anthropometry  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish La estimación de los pliegues subcutáneos (PS) para evaluar composición corporal ha sido utilizada durante años, sin embargo, su uso tiene limitaciones. La impedanciometría bioeléctrica (BIA) es un nuevo método cuyo uso ha sido recomendado en adultos. Objetivos: evaluar si la BIA para estimar grasa corporal (GC) tiene una precisión comparable a la obtenida usando PS en pediatría. Material y métodos: Se determinó % GC usando las ecuaciones de Slaughter para PS y (more) Deurenberg, Houtkooper, Schaefer y Cordain para BIA en 50 niñas, entre 9 y 11,6 años. Resultados: El nivel de concordancia, evaluado por el método de Bland y Altman, entre % GC derivado de las ecuaciones de BIA y PS, fue pobre, con una diferencia promedio de 5% ± 2DE (-5,5 a 15,5). Conclusiones: En la determinación de GC la BIA no arroja cifras concordantes con las obtenidas por PS, por lo cual no es adecuado recomendar su uso en pediatría Abstract in english Skinfold anthropometry (SKF) has been used to estimate body composition for many years but it has several limitations. Bioelectrical impedance (BIA) is a new method recently recommended to be used in adults. Aim: To determine the level of agreement for body fat mass (BF) measurement by BIA and SKF. Subjects and methods: BF was calculated using the following algorithms: Slaughter for SKF, Deurenberg, Houtkooper, Schafer and Cordain for BIA in 50 girls aged between 9 and 11 (more) ,6 years. Results: Level of agreement determined using Bland and Altman method was poor, with an average difference (SKF-BIA) of 5% ± 2 DS (-5.5 to 15.5). Conclusions: Measurements of BF determined by BIA gave poor agreement with SKF, thus the use of BIA is not recommended in pediatrics clinical practice

Urrejola N., Pascuala; Hodgson B., María Isabel; Icaza N., María Gloria

2001-01-01

170

Indian Education--Oversight; Part II: School Construction--Johnson-O'Malley. Hearings Before the Subcommittee on Elementary, Secondary, and Vocational Education of the Committee on Education and Labor, House of Representatives, 95th Congress, 1st Session (September 21 and October 6, 1977).  

Science.gov (United States)

Oversight hearing held on two days in September and October of 1977 focused on school design and construction by the Bureau of Indian Affairs (BIA) and on the supplemental and basic support offered to Indian education by the Johnson O'Malley program. On both days Dr. William Demmert, Jr., Director of the Office of Indian Education Programs, BIA,…

Congress of the U.S., Washington, DC. House Committee on Education and Labor.

171

A practical guide to bioelectrical impedance analysis using the example of chronic obstructive pulmonary disease  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Bioelectrical impedance analysis (BIA) is a simple, inexpensive, quick and non-invasive technique for measuring body composition. The clinical benefit of BIA can be further enhanced by combining it with bioelectrical impedance vector analysis (BIVA). However, there is a substantial lack of information on the practical aspects of BIA/BIVA for those primarily interested in learning how to use and interpret this method in practice. The purpose of this article is to provide some guidance on the use of BIA/BIVA with special attention to practical considerations. This report reflects the authors' practical experience with the use of single-frequency BIA in combination with BIVA, particularly in COPD patients. First, the method and principles of BIA/BIVA are briefly described. Then, a practice-oriented approach to the interpretation and analysis of characteristic examples of altered nutritional and fluid status as seen with BIA/BIVA in COPD patients (e.g. malnutrition in obese and underweight patients with COPD, water retention) is presented. As our examples show BIA/BIVA is an attractive and easy-to-learn tool for quick nutritional assessment and is therefore of great clinical benefit in daily practice.

Walter-Kroker Anja; Kroker Axel; Mattiucci-Guehlke Muriel; Glaab Thomas

2011-01-01

172

[Body composition by simple anthropometry, bioimpedance and DXA in preschool children: interrelationships among methods].  

UK PubMed Central (United Kingdom)

OBJECTIVE: To examine the interrelationships of body composition variables derived from simple anthropometry, bioelectrical impedance (BIA) and dualenergy X-ray absorptiometry (DXA). POPULATION, MATERIAL AND METHODS: A total of 230 healthy preschool children (118 males and 112 females) age 4-6 years, attending a day care center, were examined to determine body mass index (BMI) and waist circumference (WC). Percentage of body fat content (%BF) was predicted by BIA (Maltron BF- 900) and DXA (Lunar DPX-L, pediatric software). RESULTS: BMI and WC did not show significant differences among sex, while %BF by BIA or DXA did. BIA measures were lower than DXA s (p <0.0001). Correlation between BIA vs. anthropometric methods and WC vs. DXA were moderate (Pearson r= 0.43 to 0.53), whereas the other correlations were strong (r= 0.71 to 0.83). However Bland Altman comparison showed wide limits of agreement between BIA and DXA; BIA significantly underestimated %BF as determined by DXA (p <0.0001). CONCLUSION: The methods used to estimate body composition in healthy preschool children highly correlated. However, the Bland Altman procedure suggests that BIA and DXA should not be used interchangeably.

Rodríguez PN; Bermúdez EF; Rodríguez GS; Spina MA; Zeni SN; Friedman SM; Exeni RA

2008-04-01

173

76 FR 80403 - Agency Information Collection Activities; Proposed collection; Comments Request: Alien's Change...  

Science.gov (United States)

...Proposed collection; Comments Request: Alien's Change of Address Form: 33/BIA Board...2) Title of the Form/Collection: Alien's Change of Address Forms 33/BIA Board...administrative action or of any decisions in an alien's case. (5) An estimate of the...

2011-12-23

174

76 FR 64377 - Agency Information Collection Activities: Proposed Collection; Comments Requested: Alien's Change...  

Science.gov (United States)

...Proposed Collection; Comments Requested: Alien's Change of Address Forms: 33/BIA...2) Title of the Form/Collection: Alien's Change of Address Forms: 33/BIA...administrative action or of any decisions in an alien's case. (5) An estimate of the...

2011-10-18

175

Practical issues in handling data input and uncertainty in a budget impact analysis  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The objective of this paper was to address the importance of dealing systematically and comprehensively with uncertainty in a budget impact analysis (BIA) in more detail. The handling of uncertainty in health economics was used as a point of reference for addressing the uncertainty in a BIA. This ov...

Nuijten, M.J.C.; Mittendorf, T.; Persson, U.

176

Sub-Hour Solar Data for Power System Modeling From Static Spatial Variability Analysis: Preprint  

Energy Technology Data Exchange (ETDEWEB)

High penetration renewable integration studies need high quality solar power data with spatial-temporal correlations that are representative of a real system. This paper will summarize the research relating sequential point-source sub-hour global horizontal irradiance (GHI) values to static, spatially distributed GHI values. This research led to the development of an algorithm for generating coherent sub-hour datasets that span distances ranging from 10 km to 4,000 km. The algorithm, in brief, generates synthetic GHI values at an interval of one-minute, for a specific location, using SUNY/Clean Power Research, satellite-derived, hourly irradiance values for the nearest grid cell to that location and grid cells within 40 km.

Hummon, M.; Ibanez, E.; Brinkman, G.; Lew, D.

2012-12-01

177

Body composition measures of obese adolescents by the deuterium oxide dilution method and by bioelectrical impedance  

Scientific Electronic Library Online (English)

Full Text Available Abstract in english The objectives of the present study were to describe and compare the body composition variables determined by bioelectrical impedance (BIA) and the deuterium dilution method (DDM), to identify possible correlations and agreement between the two methods, and to construct a linear regression model including anthropometric measures. Obese adolescents were evaluated by anthropometric measures, and body composition was assessed by BIA and DDM. Forty obese adolescents were incl (more) uded in the study. Comparison of the mean values for the following variables: fat body mass (FM; kg), fat-free mass (FFM; kg), and total body water (TBW; %) determined by DDM and by BIA revealed significant differences. BIA overestimated FFM and TBW and underestimated FM. When compared with data provided by DDM, the BIA data presented a significant correlation with FFM (r = 0.89; P

Resende, C.M.M.; Camelo Júnior, J.S.; Vieira, M.N.C.M.; Ferriolli, E.; Pfrimer, K.; Perdoná, G.S.C.; Monteiro, J.P.

2011-11-01

178

Novel nonsense mutation (p.Y113X) in the human growth hormone receptor gene in a Brazilian patient with Laron syndrome Nova mutação nonsense (p.Y113X) no gene do receptor do hormônio do crescimento em um paciente brasileiro com síndrome de Laron  

Directory of Open Access Journals (Sweden)

Full Text Available BACKGROUND: To date, about sixty different mutations within GH receptor (GHR) gene have been described in patients with GH insensitivity syndrome (GHI). In this report, we described a novel nonsense mutation of GHR. METHODS: The patient was evaluated at the age of 6 yr, for short stature associated to clinical phenotype of GHI. GH, IGF-1, and GHBP levels were determined. The PCR products from exons 2-10 were sequenced. RESULTS: The patient had high GH (26 µg/L), low IGF-1 (22.5 ng/ml) and undetectable GHBP levels. The sequencing of GHR exon 5 disclosed adenine duplication at nucleotide 338 of GHR coding sequence (c.338dupA) in homozygous state. CONCLUSION: We described a novel mutation that causes a truncated GHR and a loss of receptor function due to the lack of amino acids comprising the transmembrane and intracellular regions of GHR protein, leading to GHI.INTRODUÇÃO: Até o momento, aproximadamente 60 diferentes mutações envolvendo o gene do receptor do GH (GHR) foram descritas em pacientes com a síndrome de insensibilidade ao GH (GHI). Neste artigo, descrevemos uma nova mutação nonsense do GHR. MÉTODOS: O paciente foi avaliado aos 6 anos de idade para baixa estatura associada ao fenótipo clínico da GHI. Níveis de GH, IGF-1 e GHBP foram determinados. Os produtos de PCR dos éxons 2-10 foram seqüenciados. RESULTADOS: O paciente apresentou níveis elevados de GH (26 µg/L), baixos de IGF-1 (22.5 ng/ml) e indetectáveis de GHBP. O seqüenciamento do éxon 5 do GHR revelou uma duplicação da adenina no nucleotídeo 338 da sequência de codificação do GHR (c.338dupA) em homozigose. CONCLUSÃO: Descrevemos uma nova mutação que causa um GHR truncado e uma perda da função do receptor devido à perda de aminoácidos compreendendo as regiões transmembrana e intracelular do receptor, levando a GHI.

Erik Trovão Diniz; Alexander A. L. Jorge; Ivo J. P. Arnhold; Arlan L. Rosenbloom; Francisco Bandeira

2008-01-01

179

Novel nonsense mutation (p.Y113X) in the human growth hormone receptor gene in a Brazilian patient with Laron syndrome/ Nova mutação nonsense (p.Y113X) no gene do receptor do hormônio do crescimento em um paciente brasileiro com síndrome de Laron  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese INTRODUÇÃO: Até o momento, aproximadamente 60 diferentes mutações envolvendo o gene do receptor do GH (GHR) foram descritas em pacientes com a síndrome de insensibilidade ao GH (GHI). Neste artigo, descrevemos uma nova mutação nonsense do GHR. MÉTODOS: O paciente foi avaliado aos 6 anos de idade para baixa estatura associada ao fenótipo clínico da GHI. Níveis de GH, IGF-1 e GHBP foram determinados. Os produtos de PCR dos éxons 2-10 foram seqüenciados. RESULT (more) ADOS: O paciente apresentou níveis elevados de GH (26 µg/L), baixos de IGF-1 (22.5 ng/ml) e indetectáveis de GHBP. O seqüenciamento do éxon 5 do GHR revelou uma duplicação da adenina no nucleotídeo 338 da sequência de codificação do GHR (c.338dupA) em homozigose. CONCLUSÃO: Descrevemos uma nova mutação que causa um GHR truncado e uma perda da função do receptor devido à perda de aminoácidos compreendendo as regiões transmembrana e intracelular do receptor, levando a GHI. Abstract in english BACKGROUND: To date, about sixty different mutations within GH receptor (GHR) gene have been described in patients with GH insensitivity syndrome (GHI). In this report, we described a novel nonsense mutation of GHR. METHODS: The patient was evaluated at the age of 6 yr, for short stature associated to clinical phenotype of GHI. GH, IGF-1, and GHBP levels were determined. The PCR products from exons 2-10 were sequenced. RESULTS: The patient had high GH (26 µg/L), low IGF- (more) 1 (22.5 ng/ml) and undetectable GHBP levels. The sequencing of GHR exon 5 disclosed adenine duplication at nucleotide 338 of GHR coding sequence (c.338dupA) in homozygous state. CONCLUSION: We described a novel mutation that causes a truncated GHR and a loss of receptor function due to the lack of amino acids comprising the transmembrane and intracellular regions of GHR protein, leading to GHI.

Diniz, Erik Trovão; Jorge, Alexander A. L.; Arnhold, Ivo J. P.; Rosenbloom, Arlan L.; Bandeira, Francisco

2008-11-01

180

Development and Reliability Testing of the FEDS System for Classifying Glenohumeral Instability  

Science.gov (United States)

Background Classification systems for glenohumeral instability (GHI) are opinion based, not validated, and poorly defined. This study is designed to methodologically develop and test a GHI classification system. Methods: Classification System Development A systematic literature review identified 18 systems for classifying GHI. The frequency characteristics used was recorded. Additionally 31 members of the American Shoulder and Elbow Surgeons responded to a survey to identify features important to characterize GHI. Frequency, Etiology, Direction, and Severity (FEDS), were found to be most important. Frequency was defined as solitary (one episode), occasional (2–5x/year), or frequent (>5x/year). Etiology was defined as traumatic or atraumatic. Direction referred to the primary direction of instability (anterior, posterior, or inferior). Severity was defined as either subluxation or dislocation. Methods: Reliability Testing Fifty GHI patients completed a questionnaire at their initial visit. One of six sports medicine fellowship trained physicians completed a similar questionnaire after examining the patient. Patients returned after two weeks and were examined by the original physician and two other physicians. Inter- and intra-rater agreement for the FEDS classification system was calculated. Results Agreement between patients and physicians was lowest for frequency (39%; k=0.130) and highest for direction (82%; k=0.636). Physician intra-rater agreement was 84– 97% for the individual FEDS characteristics (k=0.69 to 0.87)). Physician inter-rater agreement ranged from 82–90% (k=0.44 to 0.76). Conclusions The FEDS system has content validity and is highly reliable for classifying GHI. Physical examination using provocative testing to determine the primary direction of instability produces very high levels of inter- and intra-rater agreement. Level of evidence Level II, Development of Diagnostic Criteria with Consecutive Series of Patients, Diagnosis Study.

Kuhn, John E.; Helmer, Tara T.; Dunn, Warren R.; Throckmorton V, Thomas W.

2010-01-01

 
 
 
 
181

Body composition measures of obese adolescents by the deuterium oxide dilution method and by bioelectrical impedance  

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Full Text Available The objectives of the present study were to describe and compare the body composition variables determined by bioelectrical impedance (BIA) and the deuterium dilution method (DDM), to identify possible correlations and agreement between the two methods, and to construct a linear regression model including anthropometric measures. Obese adolescents were evaluated by anthropometric measures, and body composition was assessed by BIA and DDM. Forty obese adolescents were included in the study. Comparison of the mean values for the following variables: fat body mass (FM; kg), fat-free mass (FFM; kg), and total body water (TBW; %) determined by DDM and by BIA revealed significant differences. BIA overestimated FFM and TBW and underestimated FM. When compared with data provided by DDM, the BIA data presented a significant correlation with FFM (r = 0.89; P < 0.001), FM (r = 0.93; P < 0.001) and TBW (r = 0.62; P < 0.001). The Bland-Altman plot showed no agreement for FFM, FM or TBW between data provided by BIA and DDM. The linear regression models proposed in our study with respect to FFM, FM, and TBW were well adjusted. FFM obtained by DDM = 0.842 x FFM obtained by BIA. FM obtained by DDM = 0.855 x FM obtained by BIA + 0.152 x weight (kg). TBW obtained by DDM = 0.813 x TBW obtained by BIA. The body composition results of obese adolescents determined by DDM can be predicted by using the measures provided by BIA through a regression equation.

C.M.M. Resende; J.S. Camelo Júnior; M.N.C.M. Vieira; E. Ferriolli; K. Pfrimer; G.S.C. Perdoná; J.P. Monteiro

2011-01-01

182

The use of bioelectrical impedance analysis for body composition in epidemiological studies.  

UK PubMed Central (United Kingdom)

BACKGROUND/OBJECTIVES: Bioelectrical impedance analysis (BIA) is a relatively simple, inexpensive and non-invasive technique to measure body composition and is therefore suitable in field studies and larger surveys. SUBJECTS/METHODS: We performed an overview of BIA-derived body fat percentages (BF%) from 55 published studies of healthy populations aged 6-80 years. In addition, the relationship between body mass index (BMI) and body composition is documented in the context of BIA as a good alternative to closely differentiate which composition of the body better relates to the risk of cardiovascular diseases (CVDs)and all-cause mortality. RESULTS AND CONCLUSIONS: BIA-estimated percentage of BF varies greatly with population and age. BIA-estimated BF% is directly and closely related to various health outcomes such as CVDs, which is in contrast to BMI where both high and low BMIs are associated with increased risk of developing chronic diseases. Studies, among others using BIA, suggest that low BMI may reflect low muscle and high BMI fat mass (FM). BIA-derived lean and FM is directly associated with morbidity and mortality. To the contrary, BMI is rather of limited use for measuring BF% in epidemiological studies.

Böhm A; Heitmann BL

2013-01-01

183

Body composition in athletes and sports nutrition: an examination of the bioimpedance analysis technique.  

UK PubMed Central (United Kingdom)

BACKGROUND/OBJECTIVES: The purpose of the current review was to evaluate how body composition can be utilised in athletes, paying particular attention to the bioelectrical impedance analysis (BIA) technique. SUBJECTS/METHODS: Various body composition methods are discussed, as well as the unique characteristics of athletes that can lead to large errors when predicting fat mass (FM) and fat-free mass (FFM). Basic principles of BIA are discussed, and past uses of the BIA technique in athletes are explored. Single-prediction validation studies and studies tracking changes in FM and FFM are discussed with applications for athletes. RESULTS: Although extensive research in the area of BIA and athletes has been conducted, there remains a large gap in the literature pertaining to a single generalised athlete equation developed using a multiple-compartment model that includes total body water (TBW). CONCLUSIONS: Until a generalised athlete-specific BIA equation developed from a multiple-compartment is published, it is recommended that generalised equations such as those published by Lukaski and Bolonchuk and Lohman be used in athletes. However, BIA equations developed for specific athletes may also produce acceptable values and are still acceptable for use until more research is conducted. The use of a valid BIA equation/device should produce values similar to those of hydrostatic weighing and dual-energy X-ray absorptiometry. However, researchers and practitioners need to understand the individual variability associated with BIA estimations for both single assessments and repeated measurements. Although the BIA method shows promise for estimating body composition in athletes, future research should focus on the development of general athlete-specific equations using a TBW-based three- or four-compartment model.

Moon JR

2013-01-01

184

Cardiac hemodynamics and proinflammatory cytokines during biatrial and right atrial appendage pacing in patients with interatrial block.  

UK PubMed Central (United Kingdom)

PURPOSE: Interatrial block (IAB) frequently coexists with sinus node disease and is considered a risk factor of left atrial dysfunction, atrial arrhythmias, and heart failure development. Conventional right atrial appendage (RAA) pacing impairs intra- and interatrial conductions and consequently prolongs P wave duration. Biatrial (BiA) pacing helps correct IAB, but its advantageous influence remains controversial. The aim of the study was to compare the effects of BiA and RAA pacing on cardiac hemodynamics and serum concentrations of inflammatory markers and neuropeptides. METHODS: Twenty-eight patients with IAB and preserved atrio-ventricular conduction treated with BiA pacing were studied. Standard invasive hemodynamic measurements were performed during BiA and RAA pacings. Furthermore, the influence of 1 week of BiA and RAA pacing on neuropeptides: atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) and markers of inflammation: high sensitivity C-reactive protein (hs-CRP), interleukin 6 (IL-6), and neopterin was examined. RESULTS: BiA pacing resulted in significant increase of cardiac output (CO) and reduction of pulmonary capillary wedge pressure. We demonstrated significantly lower concentrations of ANP, hs-CRP, IL-6, and neopterin after 1 week of BiA in comparison to RAA pacing. BNP levels remained unchanged. CONCLUSIONS: BiA pacing in comparison to RAA pacing improves hemodynamic performance in patients with IAB and preserved atrio-ventricular conduction. BiA pacing is associated with reduction of ANP and markers of inflammation (hs-CRP, IL-6, and neopterin).

Rubaj A; Rucinski P; Kutarski A; Dabrowska-Kugacka A; Oleszczak K; Zimon B; Trojnar M; Zapolski T; Drozd J; Tarkowski A; Wysokinski A

2013-08-01

185

Accuracy of quantitative magnetic resonance and eight-electrode bioelectrical impedance analysis in normal weight and obese women.  

UK PubMed Central (United Kingdom)

BACKGROUND & AIMS: Quantitative magnetic resonance (QMR) has previously been shown to both overestimate and underestimate average fat mass (FM) in humans. Eight-electrode bioelectrical impedance analysis (BIA) has previously been found biased as well as successfully validated. We report cross-sectional accuracy of QMR and eight-electrode BIA evaluated with air displacement plethysmography (ADP) as reference method. METHODS: Fat mass and fat free mass (FFM) by QMR and eight-electrode BIA were evaluated against ADP as reference in 38 normal weight and 30 obese women. Total body water estimates by QMR and eight-electrode BIA were compared. RESULTS: Fat mass was overestimated by QMR (1 ± 2 kg, p < 0.001) and was underestimated by eight-electrode BIA (1 ± 3 kg, p = 0.03, Bonferroni adjusted p = 0.29) in normal weight women. Fat mass was underestimated by both QMR (2 ± 2 kg, p < 0.001) and eight-electrode BIA (9 ± 3 kg, p < 0.001) in obese women. Fat free mass biases were of similar magnitude but in opposite direction to FM biases. Total body water estimates were larger by eight-electrode BIA compared to QMR (1-10 kg). CONCLUSIONS: Fat mass and FFM by QMR were both biased but in opposite directions in both normal weight and obese women. Eight-electrode BIA FM and FFM estimates were imprecise and biased in obese women. Thus, QMR is more precise and more accurate than eight-electrode BIA for estimating body composition in women, but is not accurate enough to be used for individual single assessment of body composition.

Bosaeus M; Karlsson T; Holmäng A; Ellegård L

2013-07-01

186

Bioimpedância elétrica e gordura visceral: uma comparação com a tomografia computadorizada em adultos e idosos/ Bioelectrical impedance and visceral fat: a comparison with computed tomography in adults and elderly  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese OBJETIVO: Avaliar a associação entre bioimpedância elétrica (BIA) e gordura visceral (GV) em adultos e idosos. SUJEITOS E MÉTODOS: Estudo transversal, 191 indivíduos (52% mulheres, 49% idosos), estratificados por sexo, grupo etário e massa corporal. Obtiveram-se dados sobre tomografia computadorizada (área de GV) e BIA (percentual de gordura corporal total (%GCT-BIA), ângulo de fase, reactância e resistência). Análise estatística: Coeficiente de Correlação (more) de Pearson, Anova, Qui-quadrado de Pearson, Curva ROC. RESULTADOS: Áreas de GV > 130 cm² foram mais observadas em idosos e em homens. Entre as mulheres adultas, mostrou-se correlação mais forte entre GV e %GCT-BIA. Os demais grupos apresentaram resultados semelhantes e correlações estatisticamente significantes. As correlações entre GV e ângulo de fase foram fracas e sem significância estatística. As análises da Curva ROC indicaram os seguintes %GCT-BIA que identificaram excesso de GV: homens: 21,5% (adultos), 24,25% (idosos); mulheres: 35,05% (adultas), 38,45% (idosas), com sensibilidade de 78,6%, 82,1%, 83,3%, 66,7% e especificidade de 70,6%, 62,5%, 79,1%, 69%, respectivamente. CONCLUSÃO: BIA apresentou satisfatória sensibilidade e especificidade para predizer GV, entretanto, outros aparelhos e técnicas devem ser investigados para melhorar essa predição. Abstract in english OBJECTIVE: To evaluate the association between electrical bioimpedance analysis (BIA) and visceral fat (VF) in adult and elderly patients. SUBJECTS AND METHODS: This was a cross-sectional study, with a sample of 191 subjects (52% women, 49% elderly) stratified by sex, age and body mass. Computerized tomography (VF area) and BIA (percentage of total body fat (%TBF-BIA), phase angle, reactance and resistance) data were generated. Statistical analysis was based on Pearson's (more) Correlation Coefficient, Anova, Pearson's Chi-square, and ROC curves. RESULTS: VF areas > 130 cm² were more prevalent among the elderly and among men. Adult females showed a stronger correlation between GV and %TBF-BIA. The other groups showed similar results and statistically significant correlations. Correlations between GV and phase angle were weak and not statistically significant. ROC Curves analyzes showed the following %TBF-BIA, which identified excess VF: for male subjects: 21.5% (adults) and 24.25% (elderly); for female subjects: 35.05% (adults) and 38.45% (elderly) with sensitivity of 78.6%, 82.1%, 83.3%, and 66.7%, and specificity of 70.6%, 62.5%, 79.1%, and 69%, respectively. CONCLUSION: BIA was found to have satisfactory sensitivity and specificity to predict VF; however, other devices and other techniques should be investigated to improve VF prediction.

Eickemberg, Michaela; Oliveira, Carolina Cunha de; Roriz, Anna Karla Carneiro; Fontes, Gardênia Abreu Vieira; Mello, Adriana Lima; Sampaio, Lílian Ramos

2013-02-01

187

Determination of acetylsalicylic acid in tablets with salicylate ion selective electrode in a Batch Injection Analysis system  

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Full Text Available The feasibility of the use of a Batch Injection Analysis (BIA) system for potentiometric determination of acetylsalicylic acid in tablets, with a membrane ion selective electrode, was investigated. There is no significant difference between the results obtained by the proposed method and those obtained by the Standard British Pharmacopaeia method12 at the 95% confidence level. Values of 4% and 2.5% for R.S.D. were obtained by the application of the BIA-potentiometric method and for the injections respectively. About 90 determinations per hour can be performed with the proposed BIA potentiometric method.

Fernandes Julio Cesar B.; Garcia Carlos Alexandre B.; Grandin Luciane A.; Oliveira Neto Graciliano de; Godinho Oswaldo E.S.

1998-01-01

188

Bioimpedância elétrica e gordura visceral: uma comparação com a tomografia computadorizada em adultos e idosos Bioelectrical impedance and visceral fat: a comparison with computed tomography in adults and elderly  

Directory of Open Access Journals (Sweden)

Full Text Available OBJETIVO: Avaliar a associação entre bioimpedância elétrica (BIA) e gordura visceral (GV) em adultos e idosos. SUJEITOS E MÉTODOS: Estudo transversal, 191 indivíduos (52% mulheres, 49% idosos), estratificados por sexo, grupo etário e massa corporal. Obtiveram-se dados sobre tomografia computadorizada (área de GV) e BIA (percentual de gordura corporal total (%GCT-BIA), ângulo de fase, reactância e resistência). Análise estatística: Coeficiente de Correlação de Pearson, Anova, Qui-quadrado de Pearson, Curva ROC. RESULTADOS: Áreas de GV > 130 cm² foram mais observadas em idosos e em homens. Entre as mulheres adultas, mostrou-se correlação mais forte entre GV e %GCT-BIA. Os demais grupos apresentaram resultados semelhantes e correlações estatisticamente significantes. As correlações entre GV e ângulo de fase foram fracas e sem significância estatística. As análises da Curva ROC indicaram os seguintes %GCT-BIA que identificaram excesso de GV: homens: 21,5% (adultos), 24,25% (idosos); mulheres: 35,05% (adultas), 38,45% (idosas), com sensibilidade de 78,6%, 82,1%, 83,3%, 66,7% e especificidade de 70,6%, 62,5%, 79,1%, 69%, respectivamente. CONCLUSÃO: BIA apresentou satisfatória sensibilidade e especificidade para predizer GV, entretanto, outros aparelhos e técnicas devem ser investigados para melhorar essa predição.OBJECTIVE: To evaluate the association between electrical bioimpedance analysis (BIA) and visceral fat (VF) in adult and elderly patients. SUBJECTS AND METHODS: This was a cross-sectional study, with a sample of 191 subjects (52% women, 49% elderly) stratified by sex, age and body mass. Computerized tomography (VF area) and BIA (percentage of total body fat (%TBF-BIA), phase angle, reactance and resistance) data were generated. Statistical analysis was based on Pearson's Correlation Coefficient, Anova, Pearson's Chi-square, and ROC curves. RESULTS: VF areas > 130 cm² were more prevalent among the elderly and among men. Adult females showed a stronger correlation between GV and %TBF-BIA. The other groups showed similar results and statistically significant correlations. Correlations between GV and phase angle were weak and not statistically significant. ROC Curves analyzes showed the following %TBF-BIA, which identified excess VF: for male subjects: 21.5% (adults) and 24.25% (elderly); for female subjects: 35.05% (adults) and 38.45% (elderly) with sensitivity of 78.6%, 82.1%, 83.3%, and 66.7%, and specificity of 70.6%, 62.5%, 79.1%, and 69%, respectively. CONCLUSION: BIA was found to have satisfactory sensitivity and specificity to predict VF; however, other devices and other techniques should be investigated to improve VF prediction.

Michaela Eickemberg; Carolina Cunha de Oliveira; Anna Karla Carneiro Roriz; Gardênia Abreu Vieira Fontes; Adriana Lima Mello; Lílian Ramos Sampaio

2013-01-01

189

Whole-body versus Segmental Bioelectrical Impedance Analysis in Patients with Edema of the Upper Limb After Breast Cancer Treatment.  

UK PubMed Central (United Kingdom)

UNLABELLED: Aim: The purpose of this study was to compare whole-body (50 kHz alternating current) and segmental (5 kHz alternating current) bioelectrical impedance analysis (BIA) in the assessment of manifested edema of the upper limbs. PATIENTS AND METHODS: Whole-body and segmental BIA were performed in 30 patients with edema of the upper limb following breast cancer treatment. RESULTS: Pearson correlation coefficient comparing both measurements was 0.8891 (p-value <0.0001) with corresponding least squares (r(2)) of 0.7904. CONCLUSION: Whole-body BIA seems to be a suitable method in the assessment of manifested edema of the upper limbs.

Berlit S; Brade J; Tuschy B; Földi E; Walz-Eschenlohr U; Leweling H; Sütterlin M

2013-08-01

190

Binary interaction approximation to N-body problems  

International Nuclear Information System (INIS)

The binary interaction approximation (BIA) to N-body problems is proposed. The BIA conserves total linear momenta in principle. Other invariants, such as the total angular momentum and total energy, are conserved to at least 12 effective digits for a two-dimensional hydrogen plasma of T=10 keV and n=1020 m-3. For such a plasma, the total CPU time of the BIA is found to scale as approximately N1.9, while the conventional direct integration method scales as approximately N3. (author)

2010-01-01

191

Efficiency of resource use in small-scale white shrimp (Penaeus vannamei) production in Lamongan Regency, East Java Province, Indonesia Wydajno?? wykorzystania zasobów w produkcji bia?ej krewetki (Penaeus vannamei) na ma?? skal? w regencji Lamongan, prowincji Wschodnia Jawa w Indonezji  

Digital Repository Infrastructure Vision for European Research (DRIVER)

This study carried out to determine the efficiency of recourses used in white shrimp (Pe-naeus Vannamei) production in Lamongan Regency, East Java Province, Indonesia. The simple random sampling technique used to select 125 small-scale white shrimp farmers from six-study areas in Lamongan Regency. T...

Riski A. Lestariadi; Sutonya Thongrak; Ratya Anindita

192

Quantitative digital morphometry reveals low expression of desmoglein 3 protein in basal cell carcinomas: relevance to pemphigus vulgaris pathogenesis' Zmniejszona ekspresja bia?ka desmogleiny 3, ujawniona ilo?ciow? morfometri? cyfrow?, w rakach podstawnokomórkowych a patogeneza p?cherzycy zwyk?ej.  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction: Basal cell carcinoma (BCC) is the most common type of skin cancer and its incidence appears to be increasing. Objective: Reasons to undertake the study of desmoglein 3 protein (DSG3) expression in BCC were twofold: (i) DSG3-linked pemphigus vulgaris (PV), a life-threatening autoimmune blistering dermatosis, can coexist with malignancy, (ii) hair follicles, which physiologically express DSG3, apparently are involved in both PV pathogenesis (mature follicular cells) and BCC pathogenesis (stem cells of the bulge region of hair follicle). Material and methods: DSG3 expression was evaluated in BCC-affected areas in patients with BCC (22 specimens; BCC tumor), in non-BCC-affected epidermis in patients with BCC (21 specimens; control 1) and in more benign tumors than BCC (12 seborrheic keratosis specimens and 10 keratosis senilis specimens; control 2). The immunohistochemical staining on frozen sections was performed using monoclonal murine anti-DSG3 antibody. The digital microscopic image analysis with quantitative morphometric software was then used to measure the intensity of positive immunostaining signals of the DSG3 in the area of interest (tumor-affected, tumor-free). Results: There was significantly lower expression of DSG3 in BCC tumor compared to both control 1 and control 2. There was no significant difference of DSG3 expression in control 1 and control 2. Conclusions: Thus, it seems that DSG3 might have some role in BCC pathogenesis as its decreased expression in BCC-affected epidermis might reflect just locally invasive behavior of that tumor. Apparently, factors independent from DSG3 are capable to keep BCC cells in clusters, but are incapable to do the same as far as keratinocytes in PV are concerned.

Justyna Gornowicz; Monika Bowszyc-Dmochowska; Agnieszka Seraszek; El?bieta Kaczmarek; Marian Dmochowski

2009-01-01

193

Efficiency of resource use in small-scale white shrimp (Penaeus vannamei) production in Lamongan Regency, East Java Province, Indonesia Wydajno?? wykorzystania zasobów w produkcji bia?ej krewetki (Penaeus vannamei) na ma?? skal? w regencji Lamongan, prowincji Wschodnia Jawa w Indonezji  

Directory of Open Access Journals (Sweden)

Full Text Available This study carried out to determine the efficiency of recourses used in white shrimp (Pe-naeus Vannamei) production in Lamongan Regency, East Java Province, Indonesia. The simple random sampling technique used to select 125 small-scale white shrimp farmers from six-study areas in Lamongan Regency. The white shrimp production function was es-timated using Ordinary Least Square (OLS) technique. The results indicated that Double Log production function had the best fit in explaining the relationship between output of white shrimp and inputs used. The coefficient of determination (R2 = 0.846) indicated that the eighty-four point six percent of variation in output of white shrimp was explained by the independent variables in the model. Findings showed that labor, fertilizer, feed and stocking density are significant determinants of production inputs. Moreover, the estimates of the ra-tio of the value of marginal product (VMP) to marginal factor cost (MFC) revealed that the non-optimal combination of inputs among the white shrimp farmers, it showed that the aq-uaculture farms resources were inefficiently utilized for labor, feed and stocking density by 1.94, 1.93 and 171.4 respectively, while fertilizer showed otherwise by 0.11 or over uti-lized.

Riski A. Lestariadi; Sutonya Thongrak; Ratya Anindita

2012-01-01

194

Acute and long-term genotoxicity of deltamethrin to insulin-like growth factors and growth hormone in rainbow trout.  

UK PubMed Central (United Kingdom)

We report here the acute and long-term influences of deltamethrin on the expression of IGF-I, IGF-II and GH-I in rainbow trout muscles. We treated rainbow trouts with different concentrations of deltamethrin (0.25 microg/L, 1 microg/L and 2.5 microg/L) and observed the alterations in mRNA expression levels of IGF-I, IGF-II and GH-I at different time intervals (at 6th, 12th, 24th, 48th, 72nd hours and 30th day). The mRNA levels significantly decreased with increasing deltamethrin concentrations for acute administration. Interestingly, a significant recovery in GH-I expression was seen after the 72nd hour up to 30th day while no significant differences were observed for IGF-I and IGF-II between the same time intervals. Here we demonstrate that deltamethrin exposure decreases the expression of IGF-I, IGF-II and GH-I in rainbow trout which might cause undesirable outcomes not only in growth, but also in development and reproduction.

Aksakal E; Ceyhun SB; Erdo?an O; Ekinci D

2010-11-01

195

Influence of Cadmium and Mercury on Activities of Ligninolytic Enzymes and Degradation of Polycyclic Aromatic Hydrocarbons by Pleurotus ostreatus in Soil  

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The white-rot fungus Pleurotus ostreatus was able to degrade the polycyclic aromatic hydrocarbons (PAHs) benzo[a]anthracene, chrysene, benzo[b]fluoranthene, benzo[k]fluoranthene, benzo[a]pyrene, dibenzo[a,h]anthracene, and benzo[ghi]perylene in nonsterile soil both in the presence and in the absence...

Baldrian, Petr; in der Wiesche, Carsten; Gabriel, Ji?í; Nerud, František; Zadražil, František

196

An adaptive method to derive direct irradiance from global irradiance  

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Observations and estimations of solar radiation at ground level deal most frequently with global horizontal irradiance (GHI) while direct irradiance is crucial notably for Concentrated Solar Technology (CST) such as solar energy conversion systems: parabolic through, solar towers, parabolic dish or ...

Oumbe, Armel; Qu, Zhipeng; Blanc, Philippe; Bru, Hélène; Wald, Lucien

197

Organochlorine pesticides and PCBs in human tissues from Dutch citizens (1968-1983) Organochloorverbindingen en PCB's in humane weefsels van de Nederlandse bevolking (1968-1983)  

Digital Repository Infrastructure Vision for European Research (DRIVER)

In dit rapport zijn de onderzoekingen samengevat die sinds 1968 door het RIV(M) zijn uitgevoerd in opdracht van de HIL en/of GHI m.b.t. het voorkomen van de organochloorverbindingen hexachloorbenzeen (HCB), HCH-isomeren, heptachloorepoxide, dieldrin, DDT-complex en PCB's in humane weefsels....

Greve; P.A.

198

U.S.-MEXICO BORDER PROGRAM ARIZONA BORDER STUDY--QA ANALYTICAL RESULTS FOR PAHS IN BLANK SAMPLES  

Science.gov (United States)

The PAHs in Blanks data set contains the analytical results for measurements of up to 26 polynuclear aromatic hydrocarbons (PAHs) in 27 blank samples of indoor air, outdoor air, and food. The PAHs of interest include Anthracene (CAS # 120-12-7), Benzo(ghi)pyrelene (CAS# 191-24-2...

199

XYLH encodes a xylose/H(+) symporter from the highly related yeast species Debaryomyces fabryi and Debaryomyces hansenii.  

UK PubMed Central (United Kingdom)

The closely related yeasts Debaryomyces fabryi and Debaryomyces hansenii are excellent xylose consumers. We previously described the activity of a high affinity xylose/H(+) symport from an industrial strain of D. hansenii subsequently re-classified as D. fabryi. We now report the identification of the gene encoding this permease, AY347871.2. This was retrieved from D. fabryi gDNA using a degenerate primer-PCR strategy, based on conserved regions from the amino acid sequences of three well-characterised bacterial xylose/H(+) symporters. This sequence is 86% identical to another, DEHA2C11374p from D. hansenii type strain. DEHA2C11374p was conceptually ascribed to the Major Facilitator Superfamily. The putative amino acid sequence of AY347871.2 and DEHA2C11374p presented a hydrophobicity pattern compatible with plasma membrane proteins. The last was functionally expressed in Saccharomyces cerevisiae. The sensitivity of transport activity to a protonophore, confirmed its dependence on proton motive force, as expected from a symporter. We named D. fabryi AY347871.2 and D. hansenii DEHA2C11374p as XYLH from Xylose/H(+) symport. Based on the very high similarity, we suggested that Scheffersomyces stipitis Xut3 and Aspergilus nidulans AN8400.2 may also encode xylose high affinity permeases. This article is protected by copyright. All rights reserved.

Ferreira D; Nobre A; Silva ML; Tulha J; Faria-Oliveira F; Ferreira C; Lucas C

2013-06-01

200

Group and Individual Agreement between Field and Dual X-Ray Absorptiometry-Based Body Composition Techniques in Children from Standard Schools and a Sports Academy.  

UK PubMed Central (United Kingdom)

Percentage fat (%FM) and fat-free mass (FFM) were measured in 37 children from a sports academy and in 71 children from standard schools with dual x-ray absorptiometry (DXA) and bioelectrical impedance analysis (BIA) using the manufacturer's equation (Tanita) and an ethnic-specific prediction equation (Haroun). In the standard school, BIA overestimated FFM and underestimated %FM by a mean of 2.5 kg and 5.2%, respectively, using the Tanita equation. In girls from the sports academy, the Tanita equation underestimated FFM and overestimated %FM compared with DXA (mean difference BIA-DXA; FFM: -1.3 kg; %FM: 1.8%). The Haroun equation improved mean agreement between BIA and DXA in children (11 to 15 years) from the sports academy and for boys from standard schools, but reduced accuracy on individual assessments. These results have important practice implications for dietetics practitioners specializing in sports nutrition and exercise trainers.

Gerasimidis K; Shepherd S; Rashid R; Edwards CA; Ahmed F

2013-09-01

 
 
 
 
201

76 FR 26759 - Rate Adjustments for Indian Irrigation Projects  

Science.gov (United States)

...Affairs Rate Adjustments for Indian Irrigation Projects AGENCY: Bureau of Indian Affairs...BIA) owns, or has an interest in, irrigation projects located on or associated with...States. We are required to establish irrigation assessment rates to recover the...

2011-05-09

202

76 FR 58293 - Rate Adjustments for Indian Irrigation Projects  

Science.gov (United States)

...Affairs Rate Adjustments for Indian Irrigation Projects AGENCY: Bureau of Indian Affairs...BIA) owns or has an interest in, irrigation projects located on or associated with...States. We are required to establish irrigation assessment rates to recover the...

2011-09-20

203

75 FR 29577 - Rate Adjustments for Indian Irrigation Projects  

Science.gov (United States)

...Affairs Rate Adjustments for Indian Irrigation Projects AGENCY: Bureau of Indian Affairs...BIA) owns, or has an interest in, irrigation projects located on or associated with...States. We are required to establish irrigation assessment rates to recover the...

2010-05-26

204

75 FR 67095 - Rate Adjustments for Indian Irrigation Projects  

Science.gov (United States)

...Affairs Rate Adjustments for Indian Irrigation Projects AGENCY: Bureau of Indian Affairs...Affairs (BIA) owns or has an interest in irrigation projects located on or associated with...States. We are required to establish irrigation assessment rates to recover...

2010-11-01

205

77 FR 41168 - Endangered and Threatened Species; Take of Anadromous Fish  

Science.gov (United States)

...basin involving Snake River fall Chinook salmon. The permit applicants are the Washington Department of Fish and Wildlife (WDFW), Idaho Department of Fish and Game, and the Bureau of Indian Affairs (BIA) on behalf of the Nez Perce Tribe (NPT)....

2012-07-12

206

Health Consultation: Hopi Sheep Dip Vats, Hopi Indian Reservation, Arizona.  

Science.gov (United States)

The Bureau of Indian Affairs (BIA) requested the Agency for Toxic Substances and Disease Registry (ATSDR) to review the results of soil and groundwater samples obtained from the Hopi Reservation, and provide a public health opinion regarding exposures to ...

2006-01-01

207

Inhibition action of benzimidazole and benzitriazole on 12Kh18N10T steel corrosion in sulfuric acid  

International Nuclear Information System (INIS)

Rate of 12Kh18N10T steel corrosion in working solutions is determined and protection action of benzimidazole (BIA) and benzotriazole (BTA) heteroaromatic additions is calculated. Stainless steel does not practically corrode in 5% H2SO4 and protection action of BIA and BTA does not manifest itself. In pure 20% acid R=3.5 g/(m2?h), while with additions of BIA and BTA - 2.5 and 0.008 g/(m2?h) that corresponds to protection degree equal to 31.25 and 99.44% at 5% concentration of BIA the rate of corrosion is equal to 07006 g/(m2?h).

1992-01-01

208

78 FR 54669 - Draft Environmental Impact Statement for the Proposed RES Americas Moapa Solar Energy Center...  

Science.gov (United States)

...the Proposed RES Americas Moapa Solar Energy Center, Clark County, Nevada...the proposed RES Americas Moapa Solar Energy Center on the Moapa River Indian...action is the BIA approval of a solar energy ground lease and agreements...

2013-09-05

209

Navajo Legal Services and Friends of the Earth Sue Six Federal Agencies Over Alleged Careless Uranium Mining Policies.  

Science.gov (United States)

The BIA (Bureau of Indian Affairs) and the USGS (United States Geological Survey) as well as other federal agencies are the target of a lawsuit wanting more information and consideration for the plaintiffs' unique lifestyle. (RTS)

Barry, Tom

1979-01-01

210

Genetic evidence for the reduction of brassinosteroid levels by a BAHD acyltransferase-like protein in Arabidopsis.  

UK PubMed Central (United Kingdom)

Brassinosteroids (BRs) are a group of steroidal hormones involved in plant development. Although the BR biosynthesis pathways are well characterized, the BR inactivation process, which contributes to BR homeostasis, is less understood. Here, we show that a member of the BAHD (for benzylalcohol O-acetyltransferase, anthocyanin O-hydroxycinnamoyltransferase, anthranilate N-hydroxycinnamoyl/benzoyltransferase, and deacetylvindoline 4-O-acetyltransferase) acyltransferase family may play a role in BR homeostasis in Arabidopsis (Arabidopsis thaliana). We isolated two gain-of-function mutants, brassinosteroid inactivator1-1Dominant (bia1-1D) and bia1-2D, in which a novel BAHD acyltransferase-like protein was transcriptionally activated. Both mutants exhibited dwarfism, reduced male fertility, and deetiolation in darkness, which are typical phenotypes of plants defective in BR biosynthesis. Exogenous BR treatment rescued the phenotypes of the bia1-1D mutant. Endogenous levels of BRs were reduced in the bia1-1D mutant, demonstrating that BIA1 regulates endogenous BR levels. When grown in darkness, the bia1 loss-of-function mutant showed a longer hypocotyl phenotype and was more responsive to exogenous BR treatment than the wild-type plant. BIA1 expression was predominantly observed in the root, where low levels of BRs were detected. These results indicate that the BAHD acyltransferase family member encoded by BIA1 plays a role in controlling BR levels, particularly in the root and hypocotyl in darkness. Taken together, our study provides new insights into a mechanism that maintains BR homeostasis in Arabidopsis, likely via acyl conjugation of BRs.

Roh H; Jeong CW; Fujioka S; Kim YK; Lee S; Ahn JH; Choi YD; Lee JS

2012-06-01

211

Predicting abdominal adipose tissue among women with familial partial lipodystrophy.  

Science.gov (United States)

The objective of the study was to determine correlations between magnetic resonance imaging (MRI) measures of truncal adiposity (trunk fat percentage [TrF %(MRI)], visceral adipose tissue [VAT], and subcutaneous abdominal adipose tissue [SAT]), simple clinical measures (body mass index [BMI], waist circumference [WC], and waist-to-hip ratio [WHR]), and bioelectrical impedance analysis (BIA)-derived measures (total fat percentage [TF %] and TrF %(BIA)) in female patients with familial partial lipodystrophy (FPLD). Our secondary aim was to generate and cross-validate predictive equations for VAT and SAT using these simple clinical and BIA-derived variables. Measures of truncal adiposity were measured using 1.5-T MRI (VAT, SAT, and TrF %(MRI)) and Tanita (Tokyo, Japan) 8-electrode body composition analyzer BC-418 (TrF %(BIA)) in 13 female FPLD patients. Pearson correlation coefficients were determined among the various adiposity parameters (BMI, WC, WHR, SAT, VAT, TrF %(MRI), TrF %(BIA), and TF %). Equations to estimate VAT and SAT were determined among 6 of the 13 FPLD subjects using multilinear regression analysis, and the best equations were then cross-validated in the remaining 7 subjects. Variables entered into the model included age, BMI, WC, WHR, TrF %(BIA), and TF %. The TrF %(MRI) showed moderate correlation (r = 0.647, P = .02) with the TrF %(BIA), but the discrepancy between the 2 variables increased with increasing truncal adiposity. The strongest correlate for TrF %(MRI) was BMI (r = 0.886, P FPLD patients, (1) no simple clinical anthropometric measure correlates well with VAT, whereas BMI correlates well with SAT; (2) BIA measure of TF % most strongly correlated with both VAT and SAT; and (3) based on the cross-validation study, VAT but not SAT could be more reliably estimated using the regression equations derived. PMID:19375764

Joy, Tisha; Kennedy, Brooke A; Al-Attar, Salam; Rutt, Brian K; Hegele, Robert A

2009-06-01

212

Underestimation of percentage fat mass measured by bioelectrical impedance analysis compared to dual energy X-ray absorptiometry method in obese children.  

UK PubMed Central (United Kingdom)

OBJECTIVE: The aim of the study was to investigate whether there is a difference between body fat mass percentage measured by BIA and DXA method. DESIGN: Transversal study, randomized. SETTING: Lipid and Obesity Outpatient Clinic, Department of Pediatrics, University of Vienna, Austria. SUBJECTS: Twenty-seven children and adolescents from the Lipid and Obesity Outpatient Clinic, Department of Pediatrics, University of Vienna, were included in the study (14 boys and 13 girls between 6 and 18 y; mean age 12.6 and 13.1 y). METHODS: The body fat percentage was measured with BIA (bioelectrical impedance analyzer BIA 2000-M) and DXA (dual energy X-ray absorptiometry) methods on the same day. RESULTS: The mean difference between the body fat mass percentage measured by BIA and DXA was 4.48 with a standard deviation of 2.93. The results measured by BIA were almost always lower than that by DXA by about 12%. The lower and upper limit of the difference in 95% confidence interval was -5.64 and -3.32. By paired t-test, these results were significantly different (P<0.001). The correlation between the two measurements was 0.826. The mean percentage of body fat mass measured by BIA was 34.86+/-7.08% and by DXA 39.75+/-5.63%. The differences were not changed by age and body fat percentage but they were by sex. CONCLUSIONS: The results of the study show that the body fat percentages measured by BIA and DXA method were significantly different. This is very important because BIA technique is a routine technique for clinical purposes. Adjustments to the formula used for calculating the total fat mass in obese children and adolescence are necessary. Underestimation of body fat percentage measured by bioelectrical impedance analysis compared to dual X-ray absorptiometry method in obese children is three times higher with boys than with girls.

Eisenkölbl J; Kartasurya M; Widhalm K

2001-06-01

213

Comparação da gordura corporal de mulheres idosas segundo antropometria, bioimpedância e DEXA  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese Verificar a concordância e comparar o percentual de gordura corporal (%GC) através das medidas de dobras cutâneas (DC), bioimpedância (BIA) e DEXA. Foram avaliadas vinte mulheres voluntárias (62 a 79 anos), utilizando-se duas equações distintas para DC (19, 20) e BIA (23) e avaliação por DEXA. As estimativas do %GC foram comparadas através de análise de variância para medidas repetidas (ANOVA- Bonferroni), a correlação foi verificada pelo coef. de Pearson e (more) a concordância pelo procedimento de Bland & Altman (25). O %GC obtido pela BIA apresentou baixa correlação (r0,05) entre os métodos e/ou equações de BIA(RJL-CompCorp) vs. DC-Jackson (19). Para todas as outras comparações, as diferenças foram significativas (p Abstract in english Comparison of body fat using anthropometry, bioelectrical impedance and DEXA in elderly women. Verify correspondence and compare percentage body fat (%BF) estimates by skinfold thickness (SKT), bioelectrical impedance analysis (BIA) and DEXA. Twenty voluntaries women (aged 62 - 79 yr) were assessed. The body fat was estimated using two different equations of SKT(Jackson (19); Durning and Womersley, (20)), BIA using two-predictions formulas (23) and DEXA. To compare mean v (more) alues of %BF was used analysis of variance for repeated measures (ANOVA _ Bonferroni), the correlation of the inter-method was verified by Pearson correlation coefficients (r), and correspondence between prediction formulas was tested by using the approach by Bland and Altman (25). The %BF assessed by BIA (23) shown poor correlation (r0,05) between methods and/or equations by BIA (RJL-CompCorp) vs. DC-Jackson (19). There were observed significant differences (p

Rodrigues Barbosa, Aline; Santarém, José Maria; Filho, Wilson Jacob; Souza Meirelles, Eduardo; Nunes Marucci, Maria de Fátima

2001-03-01

214

Agreement of bioelectrical impedance with dual-energy X-ray absorptiometry and MRI to estimate changes in body fat, skeletal muscle and visceral fat during a 12-month weight loss intervention.  

UK PubMed Central (United Kingdom)

The aim of the present study was to analyse the agreement of bioelectrical impedance analysis (BIA) compared with dual-energy X-ray absorptiometry (DXA) and MRI in estimating body fat, skeletal muscle and visceral fat during a 12-month weight loss intervention. A total of nineteen obese adults (twelve females, seven males) aged 20·2-48·6 years, mean BMI 34·6 (SE 0·6) kg/m², participated in the study. Body fat, skeletal muscle and visceral fat index were measured by BIA (Omron BF-500; Omron Medizintechnik) and compared with DXA (body fat and skeletal muscle) at baseline, 5 and 12 months, and with MRI (visceral fat) at baseline and 5 months. The subjects lost 8·9 (SE 1·8) kg (9·0 (SE 1·7) %) of body weight during the 12-month intervention. BIA, as compared to DXA, accurately assessed loss of fat (7·0 (SE 1·5) v. 7·0 (SE 1·4) kg, P= 0·94) and muscle (1·0 (SE 0·2) v. 1·4 (SE 0·3) kg, P= 0·18). While body fat was similar by the two methods, skeletal muscle was underestimated by 1-2 kg using BIA at each time point. Compared to MRI, BIA overestimated visceral fat, especially in males. BIA and DXA showed high correlations for kg fat, both cross-sectionally and longitudinally (r 0·91-0·99). BIA, compared with DXA and MRI, detected kg muscle and visceral fat more accurately cross-sectionally (r 0·77-0·87 and r 0·40-0·78, respectively) than their changes longitudinally (r 0·24-0·61 and r 0·46, respectively). BIA is at its best when assessing the amount or changes in fat mass. It is a useful method for measuring skeletal muscle, but limited in its ability to measure visceral fat.

Pietiläinen KH; Kaye S; Karmi A; Suojanen L; Rissanen A; Virtanen KA

2013-05-01

215

Tracking fat-free mass changes in elderly men and women using single-frequency bioimpedance and dual-energy X-ray absorptiometry: a four-compartment model comparison.  

UK PubMed Central (United Kingdom)

BACKGROUND/OBJECTIVES: To compare single estimations of fat-free mass (FFM) and to track FFM using single-frequency bioelectrical impedance analysis (BIA) and dual-energy X-ray absorptiometry (DXA) compared with a four-compartment (4C) model in healthy elderly Americans. SUBJECTS/METHODS: Thirty-four men and thirty-eight women (Caucasian, ? 65 years) were included in the study. Subjects participated in either the control group or the exercise group. All testing and training took place during the 21-week investigation. Body composition assessments using nine BIA equations, DXA and a 4C model were performed during weeks 1, 12 and 24 of the study. RESULTS: Single estimations for DXA and BIA produced high r values (0.79-0.95) and low standard error of estimate values (1.62-3.3 kg), producing subjective ratings of 'ideal' for men and 'excellent' for women. Both DXA and two BIA equations revealed the same significance when comparing groups and times with the 4C model. Individual accuracy for tracking changes was similar among BIA equations and DXA compared with the 4C model, with a total agreement of 25% for BIA and 27% for DXA compared with the 4C model. CONCLUSIONS: The current data in combination with the reliability errors for both BIA and DXA FFM estimations suggest that individual results should be interpreted with caution if FFM changes are <5 kg. However, DXA and BIA are both valid methods that can be used interchangeably to estimate FFM at a single time point or for tracking changes in FFM in small groups (15-22) of healthy American older adults.

Moon JR; Stout JR; Smith-Ryan AE; Kendall KL; Fukuda DH; Cramer JT; Moon SE

2013-01-01

216

Errors in estimating peritoneal fluid by bioelectrical impedance analysis and total body electrical conductivity.  

Science.gov (United States)

Whole-body bioelectrical impedance analysis (BIA) and total body electrical conductivity (TOBEC) have been used to estimate body composition and generalized changes in total body water (TBW). The sensitivity of these methods to measure small, rapid, localized changes in body water has not been fully evaluated. We compared the prediction of TBW by whole-body and segmental BIA and TOBEC with deuterium oxide dilution (D2O) in 10 control subjects and 7 renal failure patients receiving continuous ambulatory peritoneal dialysis (CAPD) prior to and after dialysate infusion. Using D2O as the reference method, there was no significant mean residual error between TBW predicted by BIA and TOBEC in controls (-1.2 +/- 1.5 and -0.9 +/- 1.0 kg) and CAPD patients pre-infusion (-1.0 +/- 2.0 and 0.29 +/- 2.01 kg). After infusing 1.9 +/- 0.18 kg dialysate, the mean residual error between change in body weight and the three methods was -0.44 +/- 0.53 kg for D2O (p < 0.1), -1.7 +/- 0.25 kg for BIA (p < 0.0001), and 1.2 +/- 0.4 kg for TOBEC (p < 0.001). Segmental BIA detected a 7.6% reduction in trunkal resistance with no significant change across the limbs, consistent with abdominal fluid accumulation. It is concluded that whole-body BIA underpredicts and TOBEC overpredicts small changes in peritoneal fluids. PMID:8382711

Rallison, L R; Kushner, R F; Penn, D; Schoeller, D A

1993-02-01

217

Errors in estimating peritoneal fluid by bioelectrical impedance analysis and total body electrical conductivity.  

UK PubMed Central (United Kingdom)

Whole-body bioelectrical impedance analysis (BIA) and total body electrical conductivity (TOBEC) have been used to estimate body composition and generalized changes in total body water (TBW). The sensitivity of these methods to measure small, rapid, localized changes in body water has not been fully evaluated. We compared the prediction of TBW by whole-body and segmental BIA and TOBEC with deuterium oxide dilution (D2O) in 10 control subjects and 7 renal failure patients receiving continuous ambulatory peritoneal dialysis (CAPD) prior to and after dialysate infusion. Using D2O as the reference method, there was no significant mean residual error between TBW predicted by BIA and TOBEC in controls (-1.2 +/- 1.5 and -0.9 +/- 1.0 kg) and CAPD patients pre-infusion (-1.0 +/- 2.0 and 0.29 +/- 2.01 kg). After infusing 1.9 +/- 0.18 kg dialysate, the mean residual error between change in body weight and the three methods was -0.44 +/- 0.53 kg for D2O (p < 0.1), -1.7 +/- 0.25 kg for BIA (p < 0.0001), and 1.2 +/- 0.4 kg for TOBEC (p < 0.001). Segmental BIA detected a 7.6% reduction in trunkal resistance with no significant change across the limbs, consistent with abdominal fluid accumulation. It is concluded that whole-body BIA underpredicts and TOBEC overpredicts small changes in peritoneal fluids.

Rallison LR; Kushner RF; Penn D; Schoeller DA

1993-02-01

218

Validity of leg-to-leg bioelectrical impedance measurement in males.  

UK PubMed Central (United Kingdom)

BACKGROUND: This study determined the validity of the leg-to-leg bioelectrical impedance analysis (BIA) system (Tanita Body Fat Analyzer, TBF 105, Tanita Corporation of America, Inc., Arlington Heights, IL) in estimating body composition in males. METHODS: EXPERIMENTAL DESIGN: Fat-free mass (FFM) was estimated using BIA and underwater weighing, and compared. SETTING: Subjects were recruited from the community. PARTICIPANTS: Heterogeneous group of males (N=192) was recruited, with a mean+/-SD age of 39.0+/-16.8 yrs; body mass index, 26.0+/-4.0 kg/m2, percent body fat, 18.1+/-8.9 percent. MEASURES: Prior to BIA testing, subjects were required to adhere to standard BIA testing guidelines, and bioelectrical impedance was measured in subjects standing erect with bare feet on the analyzer's footpads, and wearing a swimsuit. Underwater weighing was conducted using standard procedures, with direct measurement of residual volume. RESULTS: A Bland-Altman plot of difference between FFM measured by underwater weighing and BIA versus average FFM by the two methods showed no systematic difference (mean difference, 0.07+/-3.5 kg). FFM was estimated at 66.3+/-8.6 kg with underwater weighing, and 66.2+/-7.7 kg with BIA (r=0.92, p<0.001; SEE 3.5 kg). CONCLUSIONS: These data indicate that the leg-to-leg bioelectrical impedance system accurately assesses FFM in a heterogenous group of males when compared to underwater weighing.

Cable A; Nieman DC; Austin M; Hogen E; Utter AC

2001-09-01

219

Fat-free mass in chronic illness: comparison of bioelectrical impedance and dual-energy x-ray absorptiometry in 480 chronically ill and healthy subjects.  

UK PubMed Central (United Kingdom)

Assessment of fat-free mass (FFM) and fat mass in ambulatory and hospitalized patients permits optimal adaptation of nutrition support. Recent methods for the determination of FFM are dual-energy x-ray absorptiometry (DXA) and bioelectrical impedance analysis (BIA). The purpose of this study was to determine if the BIA-determined FFM as estimated by the formula by Kotler et al. and the Geneva formula could be validated when compared to DXA-determined FFM in subjects with various diagnoses. Body composition was measured by BIA and DXA in 480 subjects including healthy young men and women, elite female runners, and patients with various pathologies (including chronic obstructive and restrictive pulmonary disease patients; cystic fibrosis patients; lung, heart, and liver transplantation patients [both pre- and post-], and hemiplegic and AIDS patients). The present results suggest that BIA is relevant in the clinical assessment of body composition, but BIA formulas appropriate to the subject pool must be used for evaluation of FFM and fat mass. The BIA formula by Kotler et al. is appropriate for healthy subjects and patients with AIDS, cystic fibrosis, and pre- or postliver transplantation. The Geneva formula is more appropriate in pulmonary diseases and hemiplegic subjects with normal weight.

Pichard C; Kyle UG; Slosman DO

1999-09-01

220

Bioelectrical impedance and visceral fat: a comparison with computed tomography in adults and elderly  

International Nuclear Information System (INIS)

Objective: To evaluate the association between electrical bioimpedance analysis (BIA) and visceral fat (VF) in adult and elderly patients. Subjects and methods: This was a cross-sectional study, with a sample of 191 subjects (52% women, 49% elderly) stratified by sex, age and body mass. Computerized tomography (VF area) and BIA (percentage of total body fat (%TBF-BIA), phase angle, reactance and resistance) data were generated. Statistical analysis was based on Pearson's Correlation Coefficient, Anova, Pearson's Chi-square, and ROC curves. Results: VF areas ? 130 cm2 were more prevalent among the elderly and among men. Adult females showed a stronger correlation between GV and %TBF-BIA. The other groups showed similar results and statistically significant correlations. Correlations between GV and phase angle were weak and not statistically significant. ROC Curves analyzes showed the following %TBF-BIA, which identified excess VF: for male subjects: 21.5% (adults) and 24.25% (elderly); for female subjects: 35.05% (adults) and 38.45% (elderly) with sensitivity of 78.6%, 82.1%, 83.3%, and 66.7%, and specificity of 70.6%, 62.5%, 79.1%, and 69%, respectively. Conclusion: BIA was found to have satisfactory sensitivity and specificity to predict VF; however, other devices and other techniques should be investigated to improve VF prediction. (author)

2013-01-01

 
 
 
 
221

[Bioelectrical impedance and visceral fat: a comparison with computed tomography in adults and elderly].  

UK PubMed Central (United Kingdom)

OBJECTIVE: To evaluate the association between electrical bioimpedance analysis (BIA) and visceral fat (VF) in adult and elderly patients. SUBJECTS AND METHODS: This was a cross-sectional study, with a sample of 191 subjects (52% women, 49% elderly) stratified by sex, age and body mass. Computerized tomography (VF area) and BIA (percentage of total body fat (%TBF-BIA), phase angle, reactance and resistance) data were generated. Statistical analysis was based on Pearson's Correlation Coefficient, Anova, Pearson's Chi-square, and ROC curves. RESULTS: VF areas > 130 cm² were more prevalent among the elderly and among men. Adult females showed a stronger correlation between GV and %TBF-BIA. The other groups showed similar results and statistically significant correlations. Correlations between GV and phase angle were weak and not statistically significant. ROC Curves analyzes showed the following %TBF-BIA, which identified excess VF: for male subjects: 21.5% (adults) and 24.25% (elderly); for female subjects: 35.05% (adults) and 38.45% (elderly) with sensitivity of 78.6%, 82.1%, 83.3%, and 66.7%, and specificity of 70.6%, 62.5%, 79.1%, and 69%, respectively. CONCLUSION: BIA was found to have satisfactory sensitivity and specificity to predict VF; however, other devices and other techniques should be investigated to improve VF prediction.

Eickemberg M; Oliveira CC; Roriz AK; Fontes GA; Mello AL; Sampaio LR

2013-02-01

222

Is bioelectrical impedance accurate for use in large epidemiological studies?  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Percentage of body fat is strongly associated with the risk of several chronic diseases but its accurate measurement is difficult. Bioelectrical impedance analysis (BIA) is a relatively simple, quick and non-invasive technique, to measure body composition. It measures body fat accurately in controlled clinical conditions but its performance in the field is inconsistent. In large epidemiologic studies simpler surrogate techniques such as body mass index (BMI), waist circumference, and waist-hip ratio are frequently used instead of BIA to measure body fatness. We reviewed the rationale, theory, and technique of recently developed systems such as foot (or hand)-to-foot BIA measurement, and the elements that could influence its results in large epidemiologic studies. BIA results are influenced by factors such as the environment, ethnicity, phase of menstrual cycle, and underlying medical conditions. We concluded that BIA measurements validated for specific ethnic groups, populations and conditions can accurately measure body fat in those populations, but not others and suggest that for large epdiemiological studies with diverse populations BIA may not be the appropriate choice for body composition measurement unless specific calibration equations are developed for different groups participating in the study.

Dehghan Mahshid; Merchant Anwar T

2008-01-01

223

Seasonal and geographical variation of Linke turbidity factor and its effect on global horizontal irradiance estimation: UAE case study  

Science.gov (United States)

In a clear-sky condition, solar radiation travelling through the Earth's atmosphere encounters atmospheric attenuation caused by several factors. Scattering of solar radiation is mainly caused by air molecules, water vapor, water droplets and dust. On the other hand, the absorption of solar radiation is usually related to the presence of O3, water vapor and CO2 layers in the upper atmosphere. Linke turbidity factor (TL) is commonly used to model the attenuation of solar radiation in the atmosphere. TL is the key parameter used in the Heliosat model, which is developed to estimate the global horizontal irradiance (GHI) at the surface of the earth. TL is calculated by the following equation: T_L=?/?_R where ? is the optical thickness of the whole atmosphere, and ?R is the optical thickness of the Rayleigh atmosphere, i.e. the clear and dry atmosphere. The problem with TL is its dependence on the air mass (m). Therefore, TL is normalized to an air mass of 2 in order to reduce the daily variance. In this study, the monthly TL(m=2) is computed over 7 ground-based stations available in the UAE (figure 1). Spatial and temporal analysis was performed to assess the seasonal and the geographical distribution of TL over the UAE. The computed TL(m=2) values are then applied in the Heliosat model to compare between the measured and modeled GHI values. The model treats the atmospheric and cloud transmittances separately. First, clear-sky direct normal irradiance (DNI) and diffused horizontal irradiance (DHI) values are computed using TL(m=2), solar zenith angle, air mass, sun-earth distance correction, solar constant and the Rayleigh optical depth, from that the clear-sky GHI is determined. Next, the cloud index is derived from the HRV channel available from the SEVIRI instrument, and from that the cloud transmission is computed. The product of the cloud transmission and the clear-sky GHI produces the modeled GHI. The comparison between TL calculated over the seven stations show higher turbidity for the 4 inland stations (stations 4-7) in the summer compared to coastal and near-coastal stations (stations 1-3). This difference could be explained by the high dust generation in desert areas surrounding inland stations, in summer dry and hot weather. A preliminary comparison has been performed between the modeled and the measured GHI values over four inland stations (stations 4-7). The obtained results show RMSE and r2 values ranging between 16.7-18% and 0.95-0.96, respectively.

Eissa, Y. A.; Ghedira, H.

2011-12-01

224

A comparison of fat mass and skeletal muscle mass estimation in male ultra-endurance athletes using bioelectrical impedance analysis and different anthropometric methods Comparación de la masa grasa y muscular estimada en atletas varones de ultra-resistencia utilizando la bioimpedancia eléctrica y diferentes métodos antropométricos  

Directory of Open Access Journals (Sweden)

Full Text Available Two hundred and fifty seven male Caucasian ultraendurance athletes were recruited, pre-race, before different swimming, cycling, running and triathlon races. Fat mass and skeletal muscle mass were estimated using bioelectrical impedance analysis (BIA) and anthropometric methods in order to investigate whether the use of BIA or anthropometry would be useful under field conditions. Total body fat estimated using BIA was significantly high (P Se reclutaron a 257 hombres caucasianos que eran atletas de alto rendimiento, antes de competir en diferentes pruebas triatlón de natación, ciclismo y carrera. Se estimaron la masa grasa y la masa de músculo esquelético utilizando un análisis de impedancia bioeléctrica (BIA) y métodos antropométricos con el fin de investigar si el uso de BIA o de la antropometría sería útil en tales condiciones de campo. La grasa corporal total estimada por BIA fue significativamente mayor en comparación con la antropometría (P < 0,001). Cuando se compararon los resultados entre BIA y antropometría, se encontraron niveles de concordancia bajos a moderados. Estos resultados concuerdan con las diferencias halladas con el análisis Bland-Altman, lo que indica que la ecuación antropométrica de Ball et al. posee el mayor grado de concordancia (desviación = -3,0 ± 5,8 kg) con BIA, con Stewart et al. (desviación = -6,4 ± 6,3 kg), Faulkner (desviación = -4,7 ± 5,8 kg) y Wilmore-Siri (desviación = -4,8 ± 6,2 kg). La estimación de la masa de músculo esquelético fue significativamente superior con BIAS que con antropometría (P < 0,001). Los resultados de la ICC y del método Bland-Altman muestran que la ecuación antropométrica de Lee et al. (desviación = -5,4 ± 5,3 kg) produjo el mayor grado de concordancia. El método combinado de Janssen et al. entre antropometría y BIA mostró el menor grado de concordancia (desviación = -12,5 ± 5,7 kg). Hubo una diferencia estadísticamente significativa entre los resultados derivados de la ecuación de Lee et al. y de la de Janssen et al. (P < 0,001). En resumen, la determinación de la composición corporal en atletas de alto rendimiento utilizando BIA produjo valores significativamente mayores de masa grasa y músculo esquelético en comparación con las ecuaciones antropométricas.

B. Knechtle; A. Wirth; P. Knechtle; T. Rosemann; C. A. Rüst; R. Bescós

2011-01-01

225

Utilização da impedância bioelétrica para estimativa da massa muscular esquelética em homens idosos/ Use of bioelectrical impedance for the estimation of skeletal muscle mass in elderly men  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese O presente estudo tem como objetivos: a) verificar a concordância entre os métodos da impedância bioelétrica (BIA) e da absortometria radiológica de dupla energia (DEXA), para a estimativa da massa muscular esquelética (MME); b) analisar o poder preditivo das variáveis antropométricas e de BIA para predição da MME em idosos. Foram avaliados 60 homens idosos (61 a 80 anos), residentes na região Sul do Brasil. Mensuraram-se as variáveis antropométricas (massa c (more) orporal e estatura), as variáveis de resistência e hidratação dos tecidos livres de gordura foram medidas pela técnica da BIA tetrapolar (Biodinamics - BF-310), realizou-se também um scan de corpo inteiro através da DEXA (LUNAR PRODIGY DF + 14319 Radiation e software 7.52.002 DPX-L). A diferença entre os métodos foi verificada pelo teste ?t?, análise dos resíduos e o coeficiente de correlação. O valor preditivo das variáveis antropométricas e de BIA foi verificado pela regressão Linear Múltipla. Observou-se que a BIA superestimou em média 0,6 kg (dp= 1,59) a MME, quando comparada com a DEXA, contudo não houve diferença estatística (p Abstract in english The aim of the present study was twofold: a) to determine the agreement between bioelectrical impedance analysis (BIA) and dual energy X-ray absorptiometry (DEXA) for the estimation of skeletal muscle mass (SMM), and b) to analyze the predictive power of anthropometric variables and BIA for the prediction of SMM in the elderly. Sixty elderly men (61 to 80 years) from the southern region of Brazil were studied. Anthropometric variables (body weight and height) were measure (more) d, the resistance and hydration of fat-free tissues variables were determined by tetrapolar BIA (BF-310, Biodynamics). A whole body DEXA scan was also performed (Lunar Prodigy DF + 14319 Radiation and 7.52.002 DPX-L software). Differences between methods were analyzed using the t-test, analysis of residues and correlation coefficient. The predictive value of the anthropometric variables and BIA was evaluated by multiple linear regression. BIA overestimated SMM on average by 0.60 kg (sd=1.59) when compared to DEXA, however, no statistical difference was observed (p>0.05). There was a strong correlation between methods (r=0.90; p

Augustemak de Lima, Luiz Rodrigo; Rech, Cassiano Ricardo; Petroski, Edio Luiz

2008-12-01

226

Composición corporal en niños preescolares: comparación entre métodos antropométricos simples, bioimpedancia y absorciometría de doble haz de rayos X/ Body composition by simple anthropometry, bioimpedance and DXA in preschool children: interrelationships among methods  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Objetivo. Comparar la composición corporal estimada por dos métodos antropométricos simples y por impedanciometría (BIA, por sus siglas en inglés) y absorciometría de doble haz de rayos X (DXA, por sus siglas en inglés) y estudiar las correlaciones existentes entre ellos, en una población preescolar de Argentina. Población, material y métodos. Se estudió transversalmente una población clínicamente sana, de edad comprendida entre 4 y 6 años, de 230 niños (11 (more) 8 varones y 112 niñas), que concurrían a Jardines Integrales de La Matanza, Argentina. Se determinó el índice de masa corporal (IMC), la circunferencia de cintura (Cci) y el contenido de grasa corporal, expresado como porcentaje, por BIA (Maltron BF- 900) y por DXA (densitómetro Lunar DPX-L, software pediátrico). Resultados. En IMC y Cci no se observaron diferencias estadísticamente significativas entre ambos sexos, pero sí en el porcentaje de grasa corporal por BIA o DXA. La correlación entre BIA y ambos métodos antropométricos fue moderada (r de Pearson= 0,43-0,53), al igual que entre DXA y Cci (r= 0,66), mientras que las demás correlaciones fueron fuertes (r= 0,71-0,83). Las medidas obtenidas por BIA y DXA no concordaron (prueba de Bland Altman); sin embargo, las diferencias se distribuyeron en forma homogénea a lo largo del eje horizontal e independientemente de las medias. BIA reprodujo valores más bajos de porcentaje de grasa corporal que DXA (p Abstract in english Objective. To examine the interrelationships of body composition variables derived from simple anthropometry, bioelectrical impedance (BIA) and dualenergy X-ray absorptiometry (DXA). Population, material and methods. A total of 230 healthy preschool children (118 males and 112 females) age 4-6 years, attending a day care center, were examined to determine body mass index (BMI) and waist circumference (WC). Percentage of body fat content (%BF) was predicted by BIA (Maltron (more) BF- 900) and DXA (Lunar DPX-L, pediatric software). Results. BMI and WC did not show significant differences among sex, while %BF by BIA or DXA did. BIA measures were lower than DXA´s (p

Rodríguez, Patricia N; Bermúdez, Enrique F; Rodríguez, Gabriela S; Spina, María A; Zeni, Susana N; Friedman, Silvia M; Exeni, Ramón A

2008-04-01

227

Comparison of body adiposity index (BAI) and bmi with estimations of % body fat in clinically severe obese women.  

UK PubMed Central (United Kingdom)

OBJECTIVE: Body adiposity index (BAI), a new surrogate measure of body fat (hip circumference/(height(1.5) - 18)), has been proposed as an alternative to body mass index (BMI). We compared BAI with BMI, and each of them with laboratory measures of body fat-derived from bioimpedance analysis (BIA), air displacement plethysmography (ADP), and dual-energy X-ray absorptiometry (DXA) in clinically severe obese (CSO) participants. DESIGN AND METHODS: Nineteen prebariatric surgery CSO, nondiabetic women were recruited (age = 32.6 ± 7.7 SD; BMI = 46.5 ± 9.0 kg/m(2) ). Anthropometrics and body fat percentage (% fat) were determined from BIA, ADP, and DXA. Scatter plots with lines of equality and Bland-Altman plots were used to compare BAI and BMI with % fat derived from BIA, ADP, and DXA. BAI and BMI correlated highly with each other (r = 0.90, P < 0.001). RESULTS: Both BAI and BMI correlated significantly with % fat from BIA and ADP. BAI, however, did not correlate significantly with % fat from DXA (r = 0.42, P = 0.08) whereas BMI did (r = 0.65, P = 0.003). BMI was also the single best predictor of % fat from both BIA (r(2) = 0.80, P < 0.001) and ADP (r(2) = 0.65, P < 0.001). The regression analysis showed that the standard error of the estimate (SEE), or residual error around the regression lines, was greater for BAI comparisons than for BMI comparisons with BIA, ADP, and DXA. Consistent with this, the Bland and Altman plots indicated wider 95% confidence intervals for BAI difference comparisons than for BMI difference comparisons for their respective means for BIA, ADP, and DXA. CONCLUSIONS: Thus, BAI does not appear to be an appropriate proxy for BMI in CSO women.

Geliebter A; Atalayer D; Flancbaum L; Gibson CD

2013-03-01

228

Agreement between different methods and predictive equations for resting energy expenditure in overweight and obese Brazilian men.  

UK PubMed Central (United Kingdom)

Predictive equations and methods tend to overestimate or underestimate resting energy expenditure (REE) compared with indirect calorimetry (IC). This cross-sectional study aimed to evaluate the agreement between methods and equations for REE estimation of overweight and obese Brazilian men. Data from 48 healthy volunteers, ages 20 to 43 years and with body mass index ranging from 26.4 to 35.2, were collected between October 2008 and October 2009. REE was measured by IC, using Deltatrac (IC1) and KORR-MetaCheck (IC2) devices. It was estimated by bioelectrical impedance analysis (BIA) using tetrapolar (BIA1) and bipolar (BIA2) devices, and by the equations of Mifflin, World Health Organization/Food and Agriculture Organization/United Nations University, Fleisch, Horie-Waitzberg and Gonzalez, and Ireton-Jones. The association and agreement among the methods and equations were assessed by the interclass correlation coefficient, Bland-Altman analysis, and by the percentage of the difference between values obtained from the standard method and alternative methods and equations. Most methods showed high agreement with IC1. The highest agreements were found for Mifflin (-2.14%), Fleisch (-3.05%), Horie-Waitzberg and Gonzalez (4.41%), and BIA2 (5.25%). Similar results were shown by the Bland-Altman analyses. BIA2, followed by BIA1, Ireton-Jones, Mifflin, and Fleisch, showed the highest association with IC1. Thus, the Mifflin, Fleisch, Horie-Waitzberg and Gonzalez equations, and BIA2, were the most accurate methods for REE estimation in this study. However, because those equations have shown considerable variability, they should be used cautiously. In addition, the IC2 was not found to be an accurate method for REE estimation in overweight and obese men included in this study.

de Oliveira FC; Alves RD; Zuconi CP; Ribeiro AQ; Bressan J

2012-09-01

229

Global solar radiation: Multiple on-site assessments in Abu Dhabi, UAE  

International Nuclear Information System (INIS)

Renewable energy technology and in particular solar energy is being considered worldwide due to the fluctuations in oil prices, global warming and the growing demand for energy supply. This paper investigates the climate conditions available in the United Arab Emirates (UAE) in particular Abu Dhabi to implement Photovoltaic (PV) technology. Measured solar radiation was analyzed for five different geographical locations to ensure the suitability of this region. Hourly, daily and monthly global horizontal irradiation (GHI) were collected and processed. Statistical methods were used to evaluate the computed GHI and showed high values especially during the summer period. Moreover, clearness index was calculated to investigate the frequency of cloudy sky days and results have shown a high percentage of clear days during the year. This paper highlights a promising future for Abu Dhabi in the solar energy sector and in particular Photovoltaic (PV) technology. (author)

2010-01-01

230

Greenbelt Homes Pilot Energy Efficiency Program Phase 1 Summary: Existing Conditions and Baseline Energy Use  

Energy Technology Data Exchange (ETDEWEB)

A multi-year pilot energy efficiency retrofit project has been undertaken by Greenbelt Homes, Inc, (GHI) a 1,566 co-operative of circa 1930 and '40 homes. The three predominate construction methods of the townhomes in the community are materials common to the area and climate zone including 8" CMU block, wood frame with brick veneer and wood frame with vinyl siding. GHI has established a pilot project that will serve as a basis for decision making for the roll out of a decade-long community upgrade program that will incorporate energy efficiency to the building envelope and equipment with the modernization of other systems like plumbing, mechanical equipment, and cladding.

Wiehagen, J.; Del Bianco, M.; Wood, A.

2013-02-01

231

Health workforce responses to global health initiatives funding: a comparison of Malawi and Zambia  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Shortages of health workers are obstacles to utilising global health initiative (GHI) funds effectively in Africa. This paper reports and analyses two countries' health workforce responses during a period of large increases in GHI funds. Methods Health facility record reviews were conducted in 52 facilities in Malawi and 39 facilities in Zambia in 2006/07 and 2008; quarterly totals from the last quarter of 2005 to the first quarter of 2008 inclusive in Malawi; and annual totals for 2004 to 2007 inclusive in Zambia. Topic-guided interviews were conducted with facility and district managers in both countries, and with health workers in Malawi. Results Facility data confirm significant scale-up in HIV/AIDS service delivery in both countries. In Malawi, this was supported by a large increase in lower trained cadres and only a modest increase in clinical staff numbers. Routine outpatient workload fell in urban facilities, in rural health centres and in facilities not providing antiretroviral treatment (ART), while it increased at district hospitals and in facilities providing ART. In Zambia, total staff and clinical staff numbers stagnated between 2004 and 2007. In rural areas, outpatient workload, which was higher than at urban facilities, increased further. Key informants described the effects of increased workloads in both countries and attributed staff migration from public health facilities to non-government facilities in Zambia to PEPFAR. Conclusions Malawi, which received large levels of GHI funding from only the Global Fund, managed to increase facility staff across all levels of the health system: urban, district and rural health facilities, supported by task-shifting to lower trained staff. The more complex GHI arena in Zambia, where both Global Fund and PEPFAR provided large levels of support, may have undermined a coordinated national workforce response to addressing health worker shortages, leading to a less effective response in rural areas.

Brugha Ruairí; Kadzandira John; Simbaya Joseph; Dicker Patrick; Mwapasa Victor; Walsh Aisling

2010-01-01

232

Electron-transporting PAHs with dual perylenediimides: syntheses and semiconductive characterizations.  

UK PubMed Central (United Kingdom)

An effective method was developed to prepare triphenyleno[1,2,3,4-ghi]perylenediimide derivatives, via ICl-induced annulation, dehalogenation, followed by photocyclization. A perylenediimide (PDI) dimer featuring a terphenyl bisethynylene linker was thereby transformed into a benzo[k]tetraphene fused with two benzoperylenediimides. These PDI derivatives exhibited electron mobility up to 0.079 cm(2) V(-1) s(-1) in solution-processed thin film transistors.

Zhang Z; Lei T; Yan Q; Pei J; Zhao D

2013-04-01

233

Electron-transporting PAHs with dual perylenediimides: syntheses and semiconductive characterizations.  

Science.gov (United States)

An effective method was developed to prepare triphenyleno[1,2,3,4-ghi]perylenediimide derivatives, via ICl-induced annulation, dehalogenation, followed by photocyclization. A perylenediimide (PDI) dimer featuring a terphenyl bisethynylene linker was thereby transformed into a benzo[k]tetraphene fused with two benzoperylenediimides. These PDI derivatives exhibited electron mobility up to 0.079 cm(2) V(-1) s(-1) in solution-processed thin film transistors. PMID:23446458

Zhang, Zhuoran; Lei, Ting; Yan, Qifan; Pei, Jian; Zhao, Dahui

2013-04-11

234

Predicting abdominal adipose tissue among women with familial partial lipodystrophy.  

UK PubMed Central (United Kingdom)

The objective of the study was to determine correlations between magnetic resonance imaging (MRI) measures of truncal adiposity (trunk fat percentage [TrF %(MRI)], visceral adipose tissue [VAT], and subcutaneous abdominal adipose tissue [SAT]), simple clinical measures (body mass index [BMI], waist circumference [WC], and waist-to-hip ratio [WHR]), and bioelectrical impedance analysis (BIA)-derived measures (total fat percentage [TF %] and TrF %(BIA)) in female patients with familial partial lipodystrophy (FPLD). Our secondary aim was to generate and cross-validate predictive equations for VAT and SAT using these simple clinical and BIA-derived variables. Measures of truncal adiposity were measured using 1.5-T MRI (VAT, SAT, and TrF %(MRI)) and Tanita (Tokyo, Japan) 8-electrode body composition analyzer BC-418 (TrF %(BIA)) in 13 female FPLD patients. Pearson correlation coefficients were determined among the various adiposity parameters (BMI, WC, WHR, SAT, VAT, TrF %(MRI), TrF %(BIA), and TF %). Equations to estimate VAT and SAT were determined among 6 of the 13 FPLD subjects using multilinear regression analysis, and the best equations were then cross-validated in the remaining 7 subjects. Variables entered into the model included age, BMI, WC, WHR, TrF %(BIA), and TF %. The TrF %(MRI) showed moderate correlation (r = 0.647, P = .02) with the TrF %(BIA), but the discrepancy between the 2 variables increased with increasing truncal adiposity. The strongest correlate for TrF %(MRI) was BMI (r = 0.886, P < .0001). Visceral adipose tissue was poorly associated with simple clinical measures of BMI, WC, and WHR, but was inversely correlated with TF %, TrF %(BIA), and SAT. The TF % was the strongest correlate for both SAT and VAT. Thus, the best regression equation for VAT included age, BMI, WC, and TF % (R(2) = 1.0), whereas that for SAT only included TF % (R(2) = 0.75). The corresponding standard error of the estimate for the predictive equations was approximately 0.03 % and 18.5 % of the mean value of VAT and SAT, respectively. In the cross-validation study, differences between predicted and observed values of SAT were larger than those of VAT. We conclude that, among female FPLD patients, (1) no simple clinical anthropometric measure correlates well with VAT, whereas BMI correlates well with SAT; (2) BIA measure of TF % most strongly correlated with both VAT and SAT; and (3) based on the cross-validation study, VAT but not SAT could be more reliably estimated using the regression equations derived.

Joy T; Kennedy BA; Al-Attar S; Rutt BK; Hegele RA

2009-06-01

235

Estimativa da gordura corporal através de equipamentos de bioimpedância, dobras cutâneas e pesagem hidrostática/ Comparison of body fat estimation by bioelectric impedance, skinfold thickness, and underwater weighing  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese A estimativa do percentual de gordura (%G) pela bioimpedância (BIA) tem como vantagem a simplicidade da medida. Contudo, a confiabilidade da BIA tem sofrido críticas. O objetivo deste estudo foi comparar a estimativa do %G através das técnicas de bioimpedância (RJL-101; Byodinamics A-310, Maltron BF-900 e BF-906), de dobras cutâneas (DC) e da pesagem hidrostática (PH). Observaram-se 25 indivíduos, homogeneizados segundo raça (branca), gênero (masculino) e idade (more) (18 a 36 anos). Para a medida de BIA foi utilizada a padronização proposta por Lukaski et al. (1985, 1986). Para as DC foram utilizadas as equações de å 3 DC e å 7 DC (Jackson, Pollock, 1978). Os valores de %G e de volume residual para PH foram preditos, respectivamente, pelas equações de Siri (1961) e Goldman e Becklake (1959). A análise estatística compreendeu: a) comparação entre os métodos através da ANOVA com medidas repetidas seguida de testes post-hoc de Tukey; b) correlação de Pearson (r); e c) cálculo do erro padrão de estimativa (SEE) das técnicas em relação à PH. Os resultados indicaram que: a) as medidas de BIA não diferiram significativamente, entre si, para o %G estimado; b) As medidas dos aparelhos A-310 e BF-906 não coincidiram com a PH (p Abstract in english The main advantage of the bioelectric impedance method (BIA) in the determination of body fat (%BF) is the simplicity of the procedure. However, its accuracy and reliability have been criticized. The purpose of this study was to compare the %BF obtained by BIA (RJL-101; Biodynamics A-310, Maltron BF-900 e BF-906), by skinfold thickness (ST), and by underwater weighing (UW). Twenty-five subjects, divided in homogenous groups according to age (18 to 36 years), sex (men), an (more) d race (white) participated in the study. BIA measures were taken using the Lukaski et al. standardization (1985,1986). ST was taken by using the equation of 3 and 7 skinfolds (Jackson, Pollock, 1978). The values of %BF and residual volume for the UW were estimated by the Siri (1961) and Goldman and Becklake (1959) equations. Statistical analysis was calculated by: a) repeated measures ANOVA followed by the Tukey post-hoc test; b) Pearson (r) correlation; c) standard error of estimate (SEE) of the BIA and ST compared to UW. The results indicated that: a) there were no significant differences for %BF measures obtained by the BIA devices; b) the %BF obtained by the A-310 and BF-906 devices did not match with the UW measures (p

Rodrigues, Maurício Nunes; Silva, Sidney Cavalcante da; Monteiro, Walace David; Farinatti, Paulo de Tarso Veras

2001-08-01

236

Estimativa da massa muscular esquelética em mulheres idosas: validade da impedância bioelétrica/ Validity of bioelectrical impedance analysis for the estimation of skeletal muscle mass in elderly women  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese O presente estudo tem como objetivos: a) verificar a concordância entre os métodos da impedância bioelétrica (BIA) e da absortometria radiológica de dupla energia (DXA) para a estimativa da massa muscular esquelética (MME); e b) analisar o poder preditivo de variáveis antropométricas e da BIA para a predição da MME em idosas. Foram avaliadas 120 mulheres (60 a 81 anos), residentes na região Sul do Brasil. Mensuraram-se as variáveis antropométricas (massa corp (more) oral e estatura); a resistência e hidratação dos tecidos livres de gordura foram medidas pela técnica da BIA tetrapolar (Biodinamics - BF-310), e pela DXA de corpo inteiro (Lunar Prodigy DF + 14319 Radiation e software 7.52.002 DPX-L). A diferença entre os métodos foi verificada pelo teste t pareado, análise dos resíduos e o coeficiente de correlação. O valor preditivo das variáveis antropométricas e de BIA foi verificado pela regressão linear múltipla, adotando nível de significância de p 0,01). Observou-se que a BIA subestimou em média 0,8kg (IC95%: -3,7; 2,0kg) a MME, quando comparada com a DXA. Foi observada alta correlação entre os métodos (r² = 0,75; p Abstract in english The objectives of the present study were: a) to determine the agreement between bioelectrical impedance analysis (BIA) and dual-energy X-ray absorptiometry (DXA) for the estimation of skeletal muscle mass (SMM), and b) to analyze the predictive power of anthropometric variables and BIA for the prediction of SMM in elderly women. A total of 120 women (60 to 81 years), living in the southern region of Brazil, were studied. Anthropometric variables (body weight and height) w (more) ere measured. Resistance and hydration of fat-free tissues were measured by tetrapolar BIA (Biodynamics, BF-310) and by whole-body DXA (Lunar Prodigy DF + 14319 Radiation and DPX-L software, version 7.52.002). Differences between methods were determined using the paired t-test, analysis of residuals and correlation coefficient. The predictive value of the anthropometric variables and BIA was evaluated by multiple linear regression, adopting a level of significance of p

Rech, Cassiano Ricardo; Salomons, Eline; Lima, Luiz Rodrigo Augustemak de; Petroski, Edio Luiz; Glaner, Maria Fátima

2010-04-01

237

Evolutionary Divergence of Duplicate Copies of the Growth Hormone Gene in Suckers (Actinopterygii: Catostomidae)  

Directory of Open Access Journals (Sweden)

Full Text Available Catostomid fishes (suckers) have duplicate copies of the growth hormone gene and other nuclear genes, due to a genome duplication event early in the group’s history. Yet, paralogs of GH in suckers are more than 90% conserved in nucleotide (nt) and amino acid (aa) sequence. Within paralogs across species, variation in nt and aa sequence averages 3.33% and 4.46% for GHI, and 3.22% and 2.43% for GHII, respectively. Selection tests suggest that the two GH paralogs are under strong purifying selection. Consensus trees from phylogenetic analysis of GH coding region data for 23 species of suckers, other cypriniform fishes and outgroups resolved cypriniform relationships and relationships among GHI sequences of suckers more or less consistently with analyses based on other molecular data. However, the analysis failed to resolve all sucker GHI and GHII sequences as monophyletic sister groups. This unexpected topology did not differ significantly from topologies constrained to make all GH sequences monophyletic. We attribute this result either to limitations in our GHII data set or convergent adaptive changes in GHII of tribe Catostomini.

Henry L. Bart Jr.; Paulette C. Reneau; Michael H. Doosey; Charles D. Bell

2010-01-01

238

Cis association of leukocyte Ig-like receptor 1 with MHC class I modulates accessibility to antibodies and HCMV UL18.  

UK PubMed Central (United Kingdom)

Leukocyte Ig-like receptor (LIR) 1 (CD85j/ILT2/LILRB1) is an inhibitory receptor with broad specificity for MHC class I (MHC-I) and the human CMV MHC-I homologue UL18. LIR-1 can inhibit NK cells through the conventional interaction with MHC-I expressed on a target cell (in trans) but the nature and the effects of LIR-1 interactions with MHC-I in cis are not well understood. Here we show that MHC-I expressed in cis has an impact on the detection of LIR-1 with various antibodies. We found the cis interaction alters recognition by only one of two antibodies known to block functional trans recognition by LIR-1 on NK cells. Specifically, we observed an enhancement of recognition with GHI/75 in the presence of various MHC-I alleles on 721.221 cells. We found that blocking the LIR-1 contact site with anti-MHC-I antibodies decreased detection of LIR-1 with GHI/75. We also observed a decrease in GHI/75 following acid denaturation of MHC-I. Finally, disruption of LIR-1 cis interactions with MHC-I significantly enhanced UL18-Fc binding to NK92 cells and enhanced the relative inhibition of NK92 cells by HLA-G. These results have implications for LIR-1 function in scenarios such as infection when MHC-I levels on effector cells may be increased by IFNs.

Li NL; Fu L; Uchtenhagen H; Achour A; Burshtyn DN

2013-04-01

239

Abundances of PAHs in the ISM: Confronting Observations with Experimental Results  

CERN Multimedia

We present recent UV laboratory spectra of various polycyclic aromatic hydrocarbons (PAHs) and explore the potential of these molecules as carriers of the DIBs. From a detailed comparison of gas-phase and Ne-matrix absorption spectra of anthracene, phenanthrene, pyrene, 2,3-benzofluorene, benzo[ghi]perylene, and hexabenzocoronene with new interstellar spectra, we infer upper limits in the abundance of these PAHs in the interstellar medium. Upper limits in the column densities of anthracene of $0.8 - 2.8 \\times 10^{12}$\\ cm$^{-2}$ and of pyrene and 2,3-benzofluorene ranging from $2 - 8 \\times 10^{12}$\\ cm$^{-2}$ are inferred. Upper limits in the column densities of benzo[ghi]perylene are $0.9 - 2.4 \\times 10^{13}$ and $10^{14}$ cm$^{-2}$ for phenanthrene. The measurements indicate fractional abundances of anthracene, pyrene, and 2,3-benzofluorene of a few times $10^{-10}$. Upper limits in the fractional abundance of benzo[ghi]perylene of a few times $10^{-9}$ and of phenanthrene of few times $10^{-8}$ are infe...

Gredel, R; Rouille, G; Steglich, M; Huisken, F; Henning, Th

2011-01-01

240

Modeling the cumulative effects of social exposures on health: moving beyond disease-specific models.  

UK PubMed Central (United Kingdom)

The traditional explanatory models used in epidemiology are "disease specific", identifying risk factors for specific health conditions. Yet social exposures lead to a generalized, cumulative health impact which may not be specific to one illness. Disease-specific models may therefore misestimate social factors' effects on health. Using data from the Canadian Community Health Survey and Canada 2001 Census we construct and compare "disease-specific" and "generalized health impact" (GHI) models to gauge the negative health effects of one social exposure: socioeconomic position (SEP). We use logistic and multinomial multilevel modeling with neighbourhood-level material deprivation, individual-level education and household income to compare and contrast the two approaches. In disease-specific models, the social determinants under study were each associated with the health conditions of interest. However, larger effect sizes were apparent when outcomes were modeled as compound health problems (0, 1, 2, or 3+ conditions) using the GHI approach. To more accurately estimate social exposures' impacts on population health, researchers should consider a GHI framework.

White HL; O'Campo P; Moineddin R; Matheson FI

2013-04-01

 
 
 
 
241

Cardiolipin-based respiratory complex activation in bacteria.  

UK PubMed Central (United Kingdom)

Anionic lipids play a variety of key roles in membrane function, including functional and structural effects on respiratory complexes. However, little is known about the molecular basis of these lipid-protein interactions. In this study, NarGHI, an anaerobic respiratory complex of Escherichia coli, has been used to investigate the relations in between membrane-bound proteins with phospholipids. Activity of the NarGHI complex is enhanced by anionic phospholipids both in vivo and in vitro. The anionic cardiolipin tightly associates with the NarGHI complex and is the most effective phospholipid to restore functionality of a nearly inactive detergent-solubilized enzyme complex. A specific cardiolipin-binding site is identified on the basis of the available X-ray diffraction data and of site-directed mutagenesis experiment. One acyl chain of cardiolipin is in close proximity to the heme b(D) center and is responsible for structural adjustments of b(D) and of the adjacent quinol substrate binding site. Finally, cardiolipin binding tunes the interaction with the quinol substrate. Together, our results provide a molecular basis for the activation of a bacterial respiratory complex by cardiolipin.

Arias-Cartin R; Grimaldi S; Pommier J; Lanciano P; Schaefer C; Arnoux P; Giordano G; Guigliarelli B; Magalon A

2011-05-01

242

Modeling the Cumulative Effects of Social Exposures on Health: Moving beyond Disease-Specific Models  

Directory of Open Access Journals (Sweden)

Full Text Available The traditional explanatory models used in epidemiology are “disease specific”, identifying risk factors for specific health conditions. Yet social exposures lead to a generalized, cumulative health impact which may not be specific to one illness. Disease-specific models may therefore misestimate social factors’ effects on health. Using data from the Canadian Community Health Survey and Canada 2001 Census we construct and compare “disease-specific” and “generalized health impact” (GHI) models to gauge the negative health effects of one social exposure: socioeconomic position (SEP). We use logistic and multinomial multilevel modeling with neighbourhood-level material deprivation, individual-level education and household income to compare and contrast the two approaches. In disease-specific models, the social determinants under study were each associated with the health conditions of interest. However, larger effect sizes were apparent when outcomes were modeled as compound health problems (0, 1, 2, or 3+ conditions) using the GHI approach. To more accurately estimate social exposures’ impacts on population health, researchers should consider a GHI framework.

Heather L. White; Patricia O'Campo; Rahim Moineddin; Flora I. Matheson

2013-01-01

243

Surface Radiation from GOES: A Physical Approach; Preprint  

Energy Technology Data Exchange (ETDEWEB)

Models to compute Global Horizontal Irradiance (GHI) and Direct Normal Irradiance (DNI) have been in development over the last 3 decades. These models can be classified as empirical or physical, based on the approach. Empirical models relate ground based observations with satellite measurements and use these relations to compute surface radiation. Physical models consider the radiation received from the earth at the satellite and create retrievals to estimate surface radiation. While empirical methods have been traditionally used for computing surface radiation for the solar energy industry the advent of faster computing has made operational physical models viable. The Global Solar Insolation Project (GSIP) is an operational physical model from NOAA that computes GHI using the visible and infrared channel measurements from the GOES satellites. GSIP uses a two-stage scheme that first retrieves cloud properties and uses those properties in a radiative transfer model to calculate surface radiation. NREL, University of Wisconsin and NOAA have recently collaborated to adapt GSIP to create a 4 km GHI and DNI product every 30 minutes. This paper presents an outline of the methodology and a comprehensive validation using high quality ground based solar data from the National Oceanic and Atmospheric Administration (NOAA) Surface Radiation (SURFRAD) (http://www.srrb.noaa.gov/surfrad/sitepage.html) and Integrated Surface Insolation Study (ISIS) http://www.srrb.noaa.gov/isis/isissites.html), the Solar Radiation Research Laboratory (SRRL) at National Renewable Energy Laboratory (NREL), and Sun Spot One (SS1) stations.

Habte, A.; Sengupta, M.; Wilcox, S.

2012-09-01

244

Deficiência da STAT5B: uma nova síndrome de insensibilidade ao hormônio de crescimento associada a acometimento imunológico/ STAT5B deficiency: a new growth hormone insensitivity syndrome associated to immunological dysfunction  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese Uma nova apresentação da insensibilidade ao hormônio de crescimento (IGH), causada por mutações em homozigose no gene STAT5B (transdutor de sinal e ativador de transcrição tipo 5B), foi caracterizada nos últimos anos. Sua particularidade é a associação com quadros de disfunção imunológica grave, sendo o mais característico a pneumonite intersticial linfocítica. A presença concomitante de doenças crônicas imunológicas pode fazer com que a baixa estatura (more) seja erroneamente considerada uma consequência do quadro clínico, levando ao subdiagnóstico dessa forma de IGH. O objetivo desta revisão é divulgar o conhecimento atual sobre essa rara patologia, facilitando o reconhecimento de pacientes com IGH secundária a mutações no gene STAT5B em ambulatórios de endocrinologia e de outras especialidades. Abstract in english A new presentation of growth hormone insensitivity (GHI) caused by homozygous mutations in STAT5B (signal transducer and activator of transcription 5B) gene has been characterized in the last years. Its particularity is the association with severe immune dysfunction, especially with lymphocytic interstitial pneumonitis. This may mislead physicians into considering short stature as secondary to chronic immunological disease and consequently into underdiagnosing this form o (more) f GHI. The objective of this review is to propagate current knowledge about this rare pathology, facilitating the diagnosis of patients with GHI due to STAT5B mutations in endocrinology and other specialties clinics.

Scalco, Renata C.; Pugliese-Pires, Patrícia N.; Jorge, Alexander A. L.

2013-07-01

245

Determination of acetylsalicylic acid in tablets with salicylate ion selective electrode in a Batch Injection Analysis system  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese A possibilidade do uso do sistema de Análise por Injeção em Batelada (BIA) para a determinação potencimétrica de ácido acetilsalicílico em comprimidos, com eletrodo íon seletivo de membrana, foi investigado. Não há uma diferença significativa entre os resultados obtidos pelo método do proposto e pelo método padrão da Farmacopéia Britânica, ao nível de confiaça de 95%. Valores de 4% e 2.5% para o desvio padrão relativo foram obtidos pela aplicação do (more) método BIA- potenciométrico e para as injeções respectivamente. Cerca de 90 determinações por hora podem ser realizadas pela aplicação do método descrito. Abstract in english The feasibility of the use of a Batch Injection Analysis (BIA) system for potentiometric determination of acetylsalicylic acid in tablets, with a membrane ion selective electrode, was investigated. There is no significant difference between the results obtained by the proposed method and those obtained by the Standard British Pharmacopaeia method12 at the 95% confidence level. Values of 4% and 2.5% for R.S.D. were obtained by the application of the BIA-potentiometric meth (more) od and for the injections respectively. About 90 determinations per hour can be performed with the proposed BIA potentiometric method.

Fernandes, Julio Cesar B.; Garcia, Carlos Alexandre B.; Grandin, Luciane A.; Oliveira Neto, Graciliano de; Godinho, Oswaldo E.S.

1998-05-01

246

Localized bioimpedance to assess muscle injury.  

Science.gov (United States)

Injuries to lower limb muscles are common among football players. Localized bioimpedance analysis (BIA) utilizes electrical measurements to assess soft tissue hydration and cell membrane integrity non-invasively. This study reports the effects of the severity of muscle injury and recovery on BIA variables. We made serial tetra-polar, phase-sensitive 50 kHz localized BIA measurements of quadriceps, hamstring and calf muscles of three male football players before and after injury and during recovery until return-to-play, to determine changes in BIA variables (resistance (R), reactance (Xc) and phase angle (PA)) in different degrees of muscle injury. Compared to non-injury values, R, Xc and PA decreased with increasing muscle injury severity: grade III (23.1%, 45.1% and 27.6%), grade II (20.6%, 31.6% and 13.3%) and grade I (11.9%, 23.5% and 12.1%). These findings indicate that decreases in R reflect localized fluid accumulation, and reductions in Xc and PA highlight disruption of cellular membrane integrity and injury. Localized BIA measurements of muscle groups enable the practical detection of soft tissue injury and its severity. PMID:23354019

Nescolarde, L; Yanguas, J; Lukaski, H; Alomar, X; Rosell-Ferrer, J; Rodas, G

2013-01-28

247

Body composition in urban South Asian women; development of a bioelectrical impedance analysis prediction equation.  

UK PubMed Central (United Kingdom)

BACKGROUND: Assessment of body composition plays a significant role in combating chronic disease among South Asians. Accurate assessment of body composition by bioelectrical impedance analysis (BIA) requires population-specific equations which are currently unavailable for urban South Asian women. AIM: To assess validity of direct BIA assessment and selected equations for prediction of total body water (TBW), against Deuterium ((2)H2O) dilution and develop and validate a population-specific TBW equation for urban South Asian women. SUBJECTS AND METHOD: Data of 80 urban Sri Lankan women (30-45 years) were used for this analysis. Body composition was assessed by (2)H2O dilution (reference) and BIA. Available BIA equations were assessed for validity. A new TBW equation was generated and validated. RESULTS: Direct BIA measurements and other equations did not meet validation criteria in predicting TBW. TBW by the new equation (TBW?=?3.443?+?0.342?×?(height(2)/impedance)?+?0.176?×?weight) correlated (p?

Waidyatilaka I; Lanerolle P; de Lanerolle-Dias M; Atukorala S; de Silva A

2013-07-01

248

Role of the phloem in the biochemistry and ecophysiology of benzylisoquinoline alkaloid metabolism.  

UK PubMed Central (United Kingdom)

Benzylisoquinoline alkaloids (BIAs) are a diverse group of biologically active specialized metabolites produced mainly in four plant families. BIA metabolism is likely of monophyletic origin and involves multiple enzymes yielding structurally diverse compounds. Several BIAs possess defensive properties against pathogenic microorganisms and herbivores. Opium poppy (Papaver somniferum: Papaveraceae) has emerged as a model system to investigate the cellular localization of BIA biosynthesis. Although alkaloids accumulate in the laticifer cytoplasm (latex) of opium poppy, corresponding biosynthetic enzymes and gene transcripts are localized to proximal sieve elements and companion cells, respectively. In contrast, BIA metabolism in the non-laticiferous meadow rue (Thalictrum flavum; Ranunculaceae) occurs independent of the phloem. Evidence points toward the adoption of diverse strategies for the biosynthesis and accumulation of alkaloids as defensive compounds. Recruitment of cell types involved in BIA metabolism, both within and external to the phloem, was likely driven by selection pressures unique to different taxa. The biochemistry, cell biology, ecophysiology, and evolution of BIA metabolism are considered in this context.

Lee EJ; Hagel JM; Facchini PJ

2013-01-01

249

[Comparative analysis of body composition assessment methods in healthy men and in chronic obstructive pulmonary disease patients: anthropometry, bioelectrical impedance and dual-energy X-ray absorptiometry].  

UK PubMed Central (United Kingdom)

UNLABELLED: The aim of this study was to examine the agreement between the results of body fat (BF and BF%), fat-free mass (FFM) and FFM index (FFMI= FFM/height2) as estimated by skinfold anthropometry (ANT), bioelectrical impedance (BIA) and dual-energy X-ray absorptiometry (DXA) in two groups of men (> or = 50 y), one comprising healthy individuals (n=23) and the other, patients with chronic obstructive pulmonary disease (COPD) (n=24). Comparisons between body composition techniques were done by repeated measures ANOVA; the Bland & Altman procedure was used to analyse agreement. RESULTS AND CONCLUSIONS: 1) comparison between healthy and COPD groups showed significant differences between all studied variables; 2) in the healthy group, values for BF, BF%, FFM and FFMI were not significantly different when BIA or ANT was compared to DXA; however, in COPD, values for BF and BF% were significantly higher and for FFM and FFMI significantly lower when BIA was compared to DXA; in contrast, no differences were shown between values for these variables when ANT was compared with DXA; 3) Bland & Altman test, in both groups, showed no agreement between BIA and DXA and between ANT and DXA; it was also shown that body fat was overestimated and fat free mass underestimated by BIA in relation to DXA.

Freitas Júnior IF; Rupp de Paiva SA; de Godoy I; Smaili Santos SM; Campana AO

2005-06-01

250

Localized bioimpedance to assess muscle injury.  

UK PubMed Central (United Kingdom)

Injuries to lower limb muscles are common among football players. Localized bioimpedance analysis (BIA) utilizes electrical measurements to assess soft tissue hydration and cell membrane integrity non-invasively. This study reports the effects of the severity of muscle injury and recovery on BIA variables. We made serial tetra-polar, phase-sensitive 50 kHz localized BIA measurements of quadriceps, hamstring and calf muscles of three male football players before and after injury and during recovery until return-to-play, to determine changes in BIA variables (resistance (R), reactance (Xc) and phase angle (PA)) in different degrees of muscle injury. Compared to non-injury values, R, Xc and PA decreased with increasing muscle injury severity: grade III (23.1%, 45.1% and 27.6%), grade II (20.6%, 31.6% and 13.3%) and grade I (11.9%, 23.5% and 12.1%). These findings indicate that decreases in R reflect localized fluid accumulation, and reductions in Xc and PA highlight disruption of cellular membrane integrity and injury. Localized BIA measurements of muscle groups enable the practical detection of soft tissue injury and its severity.

Nescolarde L; Yanguas J; Lukaski H; Alomar X; Rosell-Ferrer J; Rodas G

2013-02-01

251

Adipose-derived mesenchymal stem cells markedly attenuate brain infarct size and improve neurological function in rats  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background The therapeutic effect of adipose-derived mesenchymal stem cells (ADMSCs) on brain infarction area (BIA) and neurological status in a rat model of acute ischemic stroke (IS) was investigated. Methods Adult male Sprague-Dawley (SD) rats (n = 30) were divided into IS plus intra-venous 1 mL saline (at 0, 12 and 24 h after IS induction) (control group) and IS plus intra-venous ADMSCs (2.0 × 106) (treated interval as controls) (treatment group) after occlusion of distal left internal carotid artery. The rats were sacrificed and brain tissues were harvested on day 21 after the procedure. Results The results showed that BIA was larger in control group than in treatment group (p Conclusions ADMSC therapy significantly limited BIA and improved sensorimotor dysfunction after acute IS.

Leu Steve; Lin Yu-Chun; Yuen Chun-Man; Yen Chia-Hung; Kao Ying-Hsien; Sun Cheuk-Kwan; Yip Hon-Kan

2010-01-01

252

catena-Poly[[(1,10-phenanthroline)cadmium(II)]-?-2-(1,3-benzimidazol-2-ylsulfanyl)acetato-?3N1,O:N3  

Directory of Open Access Journals (Sweden)

Full Text Available In title compound, [Cd(C9H6N2O2S)(C12H8N2)]n, the CdII atom is in a distorted tetragonal-pyramidal environment, coordinated by one chelating 1,10-phenanthroline ligand, one chelating 2-(1,3-benzimidazol-2-ylsulfanyl)acetate (bia) ligand bound through one N atom and one O atom of the carboxyl group, and one N atom from a second bia ligand. Each bia ligand acts as bridge between CdII ions, forming one-dimensional coordination polymers along [010], with a shortest Cd...Cd distance of 4.27?(2)?Å.

Lin Cheng; Yan-Yan Sun; Ya-Wen Zhang; Jian-Quan Wang

2009-01-01

253

Estimativa da gordura corporal através de equipamentos de bioimpedância, dobras cutâneas e pesagem hidrostática Comparison of body fat estimation by bioelectric impedance, skinfold thickness, and underwater weighing  

Directory of Open Access Journals (Sweden)

Full Text Available A estimativa do percentual de gordura (%G) pela bioimpedância (BIA) tem como vantagem a simplicidade da medida. Contudo, a confiabilidade da BIA tem sofrido críticas. O objetivo deste estudo foi comparar a estimativa do %G através das técnicas de bioimpedância (RJL-101; Byodinamics A-310, Maltron BF-900 e BF-906), de dobras cutâneas (DC) e da pesagem hidrostática (PH). Observaram-se 25 indivíduos, homogeneizados segundo raça (branca), gênero (masculino) e idade (18 a 36 anos). Para a medida de BIA foi utilizada a padronização proposta por Lukaski et al. (1985, 1986). Para as DC foram utilizadas as equações de å 3 DC e å 7 DC (Jackson, Pollock, 1978). Os valores de %G e de volume residual para PH foram preditos, respectivamente, pelas equações de Siri (1961) e Goldman e Becklake (1959). A análise estatística compreendeu: a) comparação entre os métodos através da ANOVA com medidas repetidas seguida de testes post-hoc de Tukey; b) correlação de Pearson (r); e c) cálculo do erro padrão de estimativa (SEE) das técnicas em relação à PH. Os resultados indicaram que: a) as medidas de BIA não diferiram significativamente, entre si, para o %G estimado; b) As medidas dos aparelhos A-310 e BF-906 não coincidiram com a PH (p The main advantage of the bioelectric impedance method (BIA) in the determination of body fat (%BF) is the simplicity of the procedure. However, its accuracy and reliability have been criticized. The purpose of this study was to compare the %BF obtained by BIA (RJL-101; Biodynamics A-310, Maltron BF-900 e BF-906), by skinfold thickness (ST), and by underwater weighing (UW). Twenty-five subjects, divided in homogenous groups according to age (18 to 36 years), sex (men), and race (white) participated in the study. BIA measures were taken using the Lukaski et al. standardization (1985,1986). ST was taken by using the equation of 3 and 7 skinfolds (Jackson, Pollock, 1978). The values of %BF and residual volume for the UW were estimated by the Siri (1961) and Goldman and Becklake (1959) equations. Statistical analysis was calculated by: a) repeated measures ANOVA followed by the Tukey post-hoc test; b) Pearson (r) correlation; c) standard error of estimate (SEE) of the BIA and ST compared to UW. The results indicated that: a) there were no significant differences for %BF measures obtained by the BIA devices; b) the %BF obtained by the A-310 and BF-906 devices did not match with the UW measures (p < 0.01); c) SEE was high for all devices, except for the RJL-101; d) the correlation coefficients were low to moderate for all devices, the BF-906 showing the higher values; e) The ST showed greater values of r and fewer SEE than the BIA. In conclusion, the findings do not allow to state that a BIA device is better than the others to assess %BF, but the ST seems to be more powerful and reliable than the BIA for %BF estimation. Notwithstanding, the results should be confirmed by more sophisticated experimental designs, with a closer control of sampling bias for type I and II errors.

Maurício Nunes Rodrigues; Sidney Cavalcante da Silva; Walace David Monteiro; Paulo de Tarso Veras Farinatti

2001-01-01

254

Bioelectric impedance overestimates the body fat in overweight and underestimates in Brazilian obese women: a comparation with Segal equation 1 Impedancia bioeléctrica sobrestima la grasa corporal con sobrepeso y subestima en mujeres brasileñas obesas: una comparación con la ecuación Segal  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction: Overweight and obesity are risk factors to appearance of cardiovascular diseases and anthropometry is important as clinical tool for planning and health policymaking at population level. Thus, aim of this work was to compare the simple body fat percentage (%BF) obtained straight by bioeletric impedance (BIA) to the one obtained by the equation of Segal et al (1988), which uses the BIA resistance value, overweight among adult women. Methods: This study conducted with 86 adult women (50.5 ± 11.0 years old). Body weight and height were measured and estimated the body mass index (BMI). %BF was assessed by BIA (Biodynamics® model 450) and Segal equation. Results: %BF derived from BIA (38.0 ± 4.6%) and Segal et al (1988) (38.7 ± 8.1%) were similar (p=0.85). However, when the women were distributed, in two groups based on their BMI, overweight (n=40; BMI= 27.3 ± 1.2 kg/m²) and obesity (n=46; BMI= 36.2 ± 5.1 kg/m²), the two methods presented results significant different (p=0.000). The %BF of overweight women was 34.6±3.6% by BIA and 30.3±2.1% when estimated by Segal equation. In obese women, the %BF was 41.0±3.0% and 46.0±2.6%, respectively. Conclusion: BIA overestimated %BF in overweight (+14.2%; +3.0 kg) and underestimated in obese (-10.9%;-4.4 kg) women.Introducción: El sobrepeso y la obesidad son factores de riesgo para la aparición de enfermedades cardiovasculares y la antropometría es importante como herramienta clínica para la planificación y la formulación de políticas de salud a nivel de la población. Así el objetivo de este trabajo fue comparar el simple porcentage de grasa corporal (%GC) derivada directamente por médio del análisis de impedância bioeléctrica (BIA) con el derivada de la Segal et al (1988) la ecuación que utiliza el valor de la resistência BIA, em lãs mujeres obesas y con sobrepeso. Métodos: Este estudio, realizado con 86 mujeres adultas (50,5 ± 11,0 años de edad). El peso corporal y la altura se mide y calcula el índice de masa corporal (IMC). %GC fue evaluado por BIA (Biodynamics® model 450) y la ecuación de Segal. Resultados: %GC derivados de BIA% (38,0 ± 4,6) y Segal et al (1988) (38,7 ± 8,1%) fue similar (p = 0,85). Sin embargo, cuando las mujeres se distribuyeron en dos grupos según su IMC, el sobrepeso (n = 40; IMC= 27,3 ± 1,2 kg/m²) y obesidad (n= 46; IMC= 36,2 ± 5,1 kg/m²), los dos métodos que se presentan los resultados de diferencias significativas (p = 0,000). El %GC de las mujeres con sobrepeso fue de 34,6 ± 3,6% por la BIA y el 30,3 ± 2,1% cuando se calcula por la ecuación Segal. En las mujeres obesas, el BF% fue 41,0 ± 3,0% y el 46,0 ± 2,6%, respectivamente. Conclusión: BIA sobrestimado %GC en sobrepeso (+14,2%; +3,0 kg) y subestimado en obesos (-10,9; -4,4 kg) las mujeres.

G. D. Pimentel; A. B. Bernhard; M. R. P. Frezza; A. E. M. Rinaldi; R. C. Burini

2010-01-01

255

DOE's Energy Savings Performance Contracts Stretch Budgets in the Bureau of Indian Affairs  

Energy Technology Data Exchange (ETDEWEB)

The U.S. Department of the Interior's Bureau of Indian Affairs has found a good way to reduce energy costs, replace inefficient lighting and aging building equipment, and install renewable energy systems-all without huge increases in the BIA budget. The agency is doing this by making use of the U.S. Department of Energy's Super Energy Savings Performance Contracts (Super ESPCs) at BIA schools and other facilities throughout the country. This two-page case study describes how one BIA facility-the Sherman Indian School in Riverside, California-is cutting its energy costs with badly needed new lighting and heating and cooling equipment, and installing a new photovoltaic energy system, under a DOE Super ESPC, in which the energy services provider pays up-front costs and is repaid out of the facility's resulting energy cost savings.

2001-10-01

256

Non-magnetic semiconductor spin transistor  

CERN Document Server

We propose a spin transistor using only non-magnetic materials that exploits the characteristics of bulk inversion asymmetry (BIA) in (110) symmetric quantum wells. We show that extremely large spin splittings due to BIA are possible in (110) InAs/GaSb/AlSb heterostructures, which together with the enhanced spin decay times in (110) quantum wells demonstrates the potential for exploitation of BIA effects in semiconductor spintronics devices. Spin injection and detection is achieved using spin-dependent resonant interband tunneling and spin transistor action is realized through control of the electron spin lifetime in an InAs lateral transport channel using an applied electric field (Rashba effect). This device may also be used as a spin valve, or a magnetic field sensor. The electronic structure and spin relaxation times for the spin transistor proposed here are calculated using a nonperturbative 14-band k.p nanostructure model.

Hall, K C; Gundogdu, K; Flatté, M E; Boggess, T F; Lau, Wayne H.; Flatte, Michael E.; Boggess, Thomas F.

2003-01-01

257

The role of NF-?B1A promoter polymorphisms on coronary artery disease risk.  

Science.gov (United States)

Coronary artery disease (CAD), which is now regarded as a chronic inflammatory disease, is the leading cause of death worldwide. Nuclear factor (NF)-?B is a transcription factor that plays an important role in the regulation of the immune system. NF-?BIA is the inhibitory version of NF-?B. This study is the first investigation of the association between CAD and NF-?BIA-297 C/T, -826 C/T, -881 A/G polymorphisms in a Turkish population using PCR-RFLP method. The study population comprised 201 cases with CAD and 201 healthy controls. There was no significant difference in NF-?B1A-297 C/T and -881 A/G in allele and genotype frequencies between case and control populations. The genotype frequency of NF-?BIA-826TT in the patients with CAD was significantly higher than that of the controls (p = 0.015, adjusted OR = 7.09, 95% CI = 1.95-25.70). The patients with CAD also had significantly higher carriage rate of NF-?BIA-826T allele than the controls (p = 0.03, OR = 1.43, 95% CI = 1.03-1.99). Linkage analysis indicated a close linkage among these three variants of NF-?BIA (for case, ?(2 ) = 85.35 and p < 0.001; for control, ?(2 ) = 21.58 p < 0.001) and TTG, TTA and TCG haplotypes were associated with CAD (adjusted OR = 2.54, 95% CI = 0.88-7.27; p = 0.001, adjusted OR = 1.61, 95% CI: 0.64-4.02; p = 0.04, adjusted OR = 0.08, 95% CI = 0.01-0.64; p < 0.001, respectively). NF-?BIA-826TT genotype may be a significant risk factor and a valuable marker for the development of CAD. PMID:23692311

Özbilüm, Nil; Arslan, Serdal; Berkan, Öcal; Yanarta?, Mehmed; Aydemir, Eylem Itir

2013-06-20

258

Reliability of non-lethal assessment methods of body composition and energetic status exemplified by applications to eel (Anguilla anguilla) and carp (Cyprinus carpio)  

DEFF Research Database (Denmark)

tNon-lethal assessments of proximate body composition of fish can help unravelling the physiologicaland condition-dependent mechanisms of individual responses to ecological challenges. Common non-lethal methods designed to index nutrient composition in fish include the relative condition factor (Kn),bioelectric impedance-based assessments of body composition (BIA), and microwave-based “fat” meters(FM). Previous studies have revealed mixed findings as to the reliability of each of these. We compared theperformance of Kn, BIA and FM at different temperatures to predict energetic status of the whole bodiesof live eel (Anguilla anguilla) and carp (Cyprinus carpio) and the dorsal white muscle of carp. Homogenizedfish flesh was used for calibration. Relative dry mass was strongly correlated with relative fat content(R2up to 96.7%) and energy density (R2up to 99.1%). Thus, calibrations were only conducted for relativedry mass as an index of energetic status of a fish. FM readings were found to predict relative dry mass ofwhole body in eel (R2= 0.707) and carp (R2= 0.676), and dorsal white muscle of carp (R2= 0.814) well. Bycontrast, BIA measurements and Knwere much less suited to identify variation in relative dry mass. BIA-based models were also temperature-dependent. As a result, a regression model calibrated at 10?C andapplied to BIA measurements at 20?C was found to underestimate energetic status of a fish. By contrast,no effects of temperature on FM calibration results were found. Based on our study, the FM approach isthe most suitable method to non-lethally estimate energetic status in both, carp and eel, whereas BIA is oflimited use for energetic measurements in the same species, in contrast to other reports in the literature

Klefoth, Thomas; Skov, Christian

2013-01-01

259

Breast implant-associated ALK-negative anaplastic large cell lymphoma: a case report and discussion of possible pathogenesis.  

UK PubMed Central (United Kingdom)

Breast implant associated anaplastic large cell lymphoma (BIA-ALCL) is a recently recognized clinical entity, with only 39 well-documented cases reported worldwide, including 3 fatalities. Because of its rarity, the clinical and pathologic features of this malignancy have yet to be fully defined. Moreover, the pathogenesis of ALCL in association with textured silicone gel breast implants is poorly understood. Here we report a case of BIA-ALCL arising in a 67-year-old woman with a mastectomy due to breast cancer followed by implantation of textured silicone gel breast prosthesis. The patient presented with breast enlargement and tenderness 8 years following reconstructive surgery. MRI revealed a fluid collection surrounding the affected breast implant. Pathologic examination confirmed the presence of malignant ALCL T cells that were CD30+, CD8+, CD15+, HLA-DR+, CD25+ ALK- and p53. A diagnosis of indolent BIA-ALCL was made since tumor cells were not found outside of the capsule. Interestingly, an extensive mixed lymphocytic infiltrate and ectopic lymphoid tissue (lymphoid neogenesis) adjacent to the fibrous implant capsule were present. The patient was treated with capsulectomy and implantation of new breast prostheses. Six months later, the patient was found to have BIA-ALCL involvement of an axillary lymph node with cytogenetic evolution of the tumor. To our knowledge, this is the sixth reported case of aggressive BIA-ALCL. Unique features of this case include the association with lymphoid neogenesis and the in vivo cytogenetic progression of the tumor. This case provides insight into the potential role of chronic inflammation and genetic instability in the pathogenesis of BIA-ALCL.

George EV; Pharm J; Houston C; Al-Quran S; Brian G; Dong H; Hai W; Reeves W; Yang LJ

2013-01-01

260

Breast implant-associated ALK-negative anaplastic large cell lymphoma: a case report and discussion of possible pathogenesis.  

Science.gov (United States)

Breast implant associated anaplastic large cell lymphoma (BIA-ALCL) is a recently recognized clinical entity, with only 39 well-documented cases reported worldwide, including 3 fatalities. Because of its rarity, the clinical and pathologic features of this malignancy have yet to be fully defined. Moreover, the pathogenesis of ALCL in association with textured silicone gel breast implants is poorly understood. Here we report a case of BIA-ALCL arising in a 67-year-old woman with a mastectomy due to breast cancer followed by implantation of textured silicone gel breast prosthesis. The patient presented with breast enlargement and tenderness 8 years following reconstructive surgery. MRI revealed a fluid collection surrounding the affected breast implant. Pathologic examination confirmed the presence of malignant ALCL T cells that were CD30+, CD8+, CD15+, HLA-DR+, CD25+ ALK- and p53. A diagnosis of indolent BIA-ALCL was made since tumor cells were not found outside of the capsule. Interestingly, an extensive mixed lymphocytic infiltrate and ectopic lymphoid tissue (lymphoid neogenesis) adjacent to the fibrous implant capsule were present. The patient was treated with capsulectomy and implantation of new breast prostheses. Six months later, the patient was found to have BIA-ALCL involvement of an axillary lymph node with cytogenetic evolution of the tumor. To our knowledge, this is the sixth reported case of aggressive BIA-ALCL. Unique features of this case include the association with lymphoid neogenesis and the in vivo cytogenetic progression of the tumor. This case provides insight into the potential role of chronic inflammation and genetic instability in the pathogenesis of BIA-ALCL. PMID:23923082

George, Eva V; Pharm, John; Houston, Courtney; Al-Quran, Semar; Brian, Grey; Dong, Huijia; Hai, Wang; Reeves, Westley; Yang, Li-Jun

2013-07-15

 
 
 
 
261

Comparison of body composition by bioelectrical impedance analysis and dual-energy X-ray absorptiometry in Hispanic diabetics.  

UK PubMed Central (United Kingdom)

OBJECTIVE: The purpose of this study was to compare Tanita tetrapolar foot-to-foot bioelectrical impedance analysis (Model TBF-310, Tanita Corporation of America, Inc, Arlington Heights, IL; Tanita-BIA) and fan beam dual-energy X-ray absorptiometry (Hologic Discovery A v12.6, Waltham, MA; DXA) in diabetic patients. METHODS: Seventy Hispanic diabetic participants (23 male, 47 female; mean age: 53.03 ± 10.32 yrs; mean weight: 81.45 ± 17.65 kg; and mean body mass index: 31.40 ± 6.80 kg/m(2)) were selected from the Loma Linda University En Balance culturally-sensitive Spanish diabetes education program using the baseline data. RESULTS: DXA vs Tanita-BIA fat mass (FM), percent fat mass (%FM), and fat-free mass (FFM) were compared using Pearson's (FM: 0.96, %FM: 0.91, and FFM: 0.95), and Spearman's rank (FM: 0.94, %FM: 0.91, and FFM: 0.93) correlation coefficients. Bland-Altman analyses were also used to compare the difference (DXA - BIA) vs average of DXA and BIA results and showed general agreement between the two methods. When Tanita-BIA was regressed onto DXA, the adjusted R(2) was: FM=0.91; %FM=0.83; FFM=0.90. Gender combined concordance correlations with 95% confidence intervals were calculated using a bootstrap re-sampling of the data and found high associations [FM: 0.93 (95% CI: 0.89, 0.96)], [%FM: 0.86 (95% CI: 0.79, 0.90)], and [FFM: 0.93 (95% CI: 0.89, 0.96)]. CONCLUSION: Tanita-BIA may provide valid measures of fat, percent body fat and fat-free mass in Hispanic diabetics, and could be a convenient and practical approach for assessment in community-based research.

Beeson WL; Batech M; Schultz E; Salto L; Firek A; Deleon M; Balcazar H; Cordero-Macintyre Z

2010-01-01

262

Comparison of two bioelectrical impedance analysis instruments for determining body composition in adolescent girls.  

UK PubMed Central (United Kingdom)

The purpose of this study was to compare fat-free mass (FFM) and percent body fat determined by two bio-electrical impedance analysis (BIA) instruments against criterion estimates determined by dual-energy x-ray absorptiometry (DXA) in a multi-racial/ethnic sample of adolescent girls. BIA was assessed in 151 girls (n=51 African-American; n=45 Hispanic; n=55 Caucasian; age 12.2 +/- 1.2 yr) using the RJL Quantum II and the American Weights and Measures Body-Comp Scale (BCS). Percent body fat determined by BIA was significantly related to that determined by DXA (R(2)=0.87, SEE=2.8% for RJL vs DXA, P<0.0001; R(2)=0.71, SEE=4.4% for BCS vs DXA, P<0.0001). The agreement between DXA and BIA for FFM was also significant (R(2)=0.91, SEE=0.03 kg for RJL, P <0.0001; R(2)=0.79, SEE=0.04 kg for BCS, P <0.0001). The BCS overestimated FFM by 2.7 kg (P<0.0001) and underestimated percent body fat by over 4% (P<0.001). There were no differences in percent body fat between DXA and the RJL, and although the RJL significantly overestimated FFM, the absolute difference was <1 kg. Within each ethnic group, the RJL instrument more closely estimated FFM and percent body fat than did the BCS. Although both BIA instruments compared favorably with DXA, the RJL had better stability and accuracy than the BCS, for both the total sample and for the three ethnic groups. Considering its relatively low cost and minimal time required for technical training, BIA is a useful and appropriate technique for assessing body composition in adolescent girls.

Nichols J; Going S; Loftin M; Stewart D; Nowicki E; Pickrel J

2006-01-01

263

Benzylisoquinoline alkaloid metabolism: a century of discovery and a brave new world.  

UK PubMed Central (United Kingdom)

Benzylisoquinoline alkaloids (BIAs) are a structurally diverse group of plant specialized metabolites with a long history of investigation. Although the ecophysiological functions of most BIAs are unknown, the medicinal properties of many compounds have been exploited for centuries. These include the narcotic analgesics codeine and morphine, the antimicrobial agents sanguinarine and berberine, and the antitussive and anticancer drug noscapine. BIA biosynthesis involves a restricted number of enzyme types that catalyze landmark coupling reactions and subsequent functional group modifications. A pathogenesis-related (PR)10/Bet v1 'Pictet-Spenglerase', several O-methyl-, N-methyl- and O-acetyltransferases, cytochromes P450, FAD-dependent oxidases, non-heme dioxygenases and NADPH-dependent reductases have been implicated in the multistep pathways leading to structurally diverse alkaloids. A small number of plant species, including opium poppy (Papaver somniferum) and other members of the Ranunculales, have emerged as model systems to study BIA metabolism. The expansion of resources to include a wider range of plant species is creating an opportunity to investigate previously uncharacterized BIA pathways. Contemporary knowledge of BIA metabolism reflects over a century of research coupled with the development of key innovations such as radioactive tracing, enzyme isolation and molecular cloning, and functional genomics approaches such as virus-induced gene silencing. Recently, the emergence of transcriptomics, proteomics and metabolomics has expedited the discovery of new BIA biosynthetic genes. The growing repository of BIA biosynthetic genes is providing the parts required to apply emerging synthetic biology platforms to the development of production systems in microbes as an alternative to plants as a commecial source of valuable BIAs.

Hagel JM; Facchini PJ

2013-05-01

264

Percentage of body fat assessment using bioelectrical impedance analysis and dual-energy X-ray absorptiometry in a weight loss program for obese or overweight Chinese adults.  

UK PubMed Central (United Kingdom)

The current study aimed to compare the estimates of body fat percentage (%BF) by performing bioelectrical impedance analysis (BIA) and dual energy X-ray absorptiometry (DXA) in a sample of obese or overweight Chinese adults who participated in a weight-loss randomized control trial stratified by gender to determine whether or not BIA is a valid measurement tool. Among 189 adults [73 males, 116 females; age = 41 to 74 years; mean body mass index (BMI) = 27.3 kg/m(2)], assessments of %BF at the baseline and six months from the baseline were conducted by performing BIA and DXA. Bland-Altman analyses and multiple regression analyses were used to assess the relationships between %BFBIA and %BFDXA. Compared with DXA, BIA underestimated %BF [in males: 4.6, -2.4 to 11.7 (mean biases, 95% limit of agreement) at the baseline, 1.4, -7.4 to 10.2 at the endpoint, and 3.2, -4.8 to 11.3 in changes; in females: 5.1, -2.4 to 12.7; 2.2, -6.1 to 10.4; and 3.0, -4.8 to 10.7, respectively]. For males and females, %BFDXA proved to be a significant predictor of the difference between DXA and BIA at the baseline, the endpoint, and in changes when BMI and age were considered (in males: p<0.01 and R (2) = 23.1%, 24.1%, 20.7%, respectively; for females: p<0.001 and R (2) = 40.4%, 48.8%, 25.4%, respectively). The current study suggests that BIA provides a relatively accurate prediction of %BF in individuals with normal weight, overweight, or obesity after the end of weight-loss program, but less accurate prediction of %BF in obese individuals at baseline or weight change during the weight-loss intervention program.

Li YC; Li CI; Lin WY; Liu CS; Hsu HS; Lee CC; Chen FN; Li TC; Lin CC

2013-01-01

265

Body composition in prepubertal, HIV-infected children: a comparison of bioelectrical impedance analysis and dual-energy X-ray absorptiometry.  

UK PubMed Central (United Kingdom)

BACKGROUND: The aim of this study was to compare bioelectrical impedance analysis (BIA) equations developed for healthy pediatric populations and for HIV-infected children using dual-energy X-ray absorptiometry (DXA) as the gold standard. MATERIALS AND METHODS: A cross-sectional study was carried out with 40 prepubertal, HIV-infected children who regularly attended the Pediatric Infectious Disease Clinic at the Universidade Federal de São Paulo, São Paulo, Brazil. The study was conducted from August to November 2008. Demographic data, clinical parameters, immunological status, and use of antiretroviral therapy were obtained from the patients' medical records. We performed anthropometric parameters and body composition analyses, analyzed body composition by BIA and DXA, and compared the results obtained from BIA through using equations for both healthy and HIV-infected populations. RESULTS: The mean ± SD age of the study population was 9.8 ± 1.2 years. Half of the population were females, and 82.5% of the children were clinically classified as B and C. Total body fat, by both absolute mass and by percentage, exhibited high homogeneity between the results obtained from BIA and DXA. However, there was no concordance in fat-free mass. The equation for healthy children showed good sensitivity and specificity when comparing the percentage of total body fat measured by DXA. CONCLUSION: BIA provides reliable data on total body fat but not fat-free mass when compared with DXA. The BIA equation developed for healthy pediatric populations can be used to determine total body fat in HIV-infected children.

Palchetti CZ; Patin RV; Machado DM; Szejnfeld VL; Succi RC; Oliveira FL

2013-04-01

266

Microcystin assimilation and detoxification by Daphnia spp. in two ecosystems of different cyanotoxin concentrations  

Directory of Open Access Journals (Sweden)

Full Text Available Microcystins (MCs), the main group of cyanotoxins, can induce oxidative stress in the cells of aquatic animals. This study evaluated the sensitivity of daphniids – from two ecosystems characterised by different trophic states and habitat levels of cyanobacteria abundance – to microcystin toxicity by analysing oxidative stress parameters and MC detoxification ability. As a study site, we chose the eutrophic Sulejow reservoir, which has regular annual toxic cyanobacterial blooms, and the mesotrophic lake Bia?e, where low abundances of cyanobacteria have only recently appeared. We found much higher accumulations of MCs in tissues of Daphnia spp. in lake Bia?e, despite low toxin concentrations in this ecosystem compared with the Sulejow reservoir. Simultaneously, high levels of lipid peroxidation (LPO) and a significant decrease in glutathione (GSH) were observed in daphniid cells in lake Bia?e, while LPO levels were generally lower and GSH concentration more stable in the Sulejow reservoir. Catalase activity, which reflects more efficient oxidative protection, was always significantly higher in the reservoir than in lake Bia?e. These results demonstrate that generations of daphniids from the Sulejow reservoir had more effective antioxidant systems protecting them against the accumulation of cyanobacterial toxins; thereby, they are less susceptible to toxic effects than the daphniids from lake Bia?e. However, the presence of conjugate forms of microcystins (MC-GSH and MC-Cys) in tissues of the studied animals indicated the ability for MC detoxification by daphniids from the Sulejow reservoir and lake Bia?e. Nevertheless, the high effectiveness of antioxidant systems in daphniids coexisting with cyanobacteria for a long time in the Sulejow reservoir indicates the importance of a selective pressure exerted by toxic cyanobacterial strains that favours the most resistant daphniid genotypes.

Adrianna Wojtal-Frankiewicz; Joanna Bernasi?ska; Tomasz Jurczak; Krzysztof Gwo?dzi?ski; Piotr Frankiewicz; Marzena Wielanek

2013-01-01

267

Safety, tolerability, and pharmacokinetics of etamicastat, a novel dopamine-?-hydroxylase inhibitor, in a rising multiple-dose study in young healthy subjects.  

UK PubMed Central (United Kingdom)

BACKGROUND: Activation of the sympathetic nervous system is an important feature in hypertension and congestive heart failure. A strategy for directly modulating sympathetic nerve function is to reduce the biosynthesis of norepinephrine (noradrenaline) via inhibition of dopamine-?-hydroxylase (D?H). OBJECTIVE: To assess the safety, tolerability, and pharmacokinetics of etamicastat (BIA 5-453), a new D?H inhibitor, following repeated dosing. METHODS: A double-blind, randomized, placebo-controlled study was conducted in healthy young male volunteers. Participants received once-daily doses of placebo or etamicastat 25, 50, 100, 200, 400, or 600?mg, for 10 days. RESULTS: Etamicastat underwent N-acetylation to its metabolite BIA 5-961. Etamicastat and BIA 5-961 maximum concentrations were achieved at 1-3 and 2-4 hours, respectively, after dosing. Elimination half-lives ranged from 18.1 to 25.7 hours for etamicastat and 6.7 to 22.5 hours for BIA 5-961. Both etamicastat and BIA 5-961 followed linear pharmacokinetics. The extent of systemic exposure to etamicastat and BIA 5-961 increased in an approximately dose-proportional manner, and steady-state plasma concentrations were attained up to 9 days of dosing. Etamicastat accumulated in plasma following repeated administration. The mean observed accumulation ratio was 1.3-1.9 for etamicastat and 1.3-1.6 for BIA 5-961. Approximately 40% of the etamicastat dose was recovered in urine in the form of parent compound and BIA 5-961. There was a high variability in pharmacokinetic parameters, attributable to different N-acetyltransferase-2 (NAT2) phenotype. Urinary excretion of norepinephrine decreased following repeated administration of etamicastat. Etamicastat was generally well tolerated. There was no serious adverse event or clinically significant abnormality in clinical laboratory tests, vital signs, or ECG parameters. CONCLUSION: Etamicastat was well tolerated. Etamicastat undergoes N-acetylation, which is markedly influenced by NAT2 phenotype. NAT2 genotyping could be a step toward personalized medicine for etamicastat. TRIAL REGISTRATION: EudraCT No. 2007-004142-33.

Nunes T; Rocha JF; Vaz-da-Silva M; Igreja B; Wright LC; Falcão A; Almeida L; Soares-da-Silva P

2010-01-01

268

Validity of bioelectrical impedance analysis to estimate body composition changes after bariatric surgery in premenopausal morbidly women.  

UK PubMed Central (United Kingdom)

In obese patients, subtle variations of the hydration of soft tissues can propagate errors in bioelectrical impedance analysis (BIA) measures of body composition. Bioelectrical impedance vector analysis (BIVA) is a useful method to evaluate tissue hydration. Laparoscopic adjustable gastric banding (LAGB) is a purely restrictive bariatric surgical procedure resulting in lower fat-free mass (FFM) loss than other malabsorptive or mixed intervention. The aim of this study was to evaluate the 6- and 12-month changes in body composition in a homogeneous group of premenopausal morbidly obese women treated by LAGB by comparing the results of conventional BIA and BIVA with dual-energy X-ray absorptiometry (DXA) method. Forty-five consecutive morbidly obese patients (mean age, 35.3 +/- 9.1 years; body mass index, 34.5-48.7 kg/m(2)) were prospectively evaluated at the Endocrinology Unit of the Department of Molecular and Clinical Endocrinology and Oncology. The LAGB device (Lap-Band System; Inamed Health, Santa Barbara, CA, USA) was inserted laparoscopically. Soft tissue hydration was evaluated by BIVA; fat mass (FM) and FFM were evaluated by BIA (BIA 101 RJL, Akern Bioresearch, Firenze, Italy) and by DXA (Hologic QDR 4500A S/N 45622; Hologic Inc., Bedford, MA, USA). Pre- and postoperative BIVA vectors indicated a normal hydration in all patients. Postoperatively, the excess of body weight loss was mainly due to a decrease in FM. The regression analysis of BIA and DXA methods at baseline and at the 6- and 12-month follow-up for FM r (2) values were 0.98, 0.94, and 0.99, respectively (p < 0.001); FM% r (2) values were 0.91, 0.89, and 0.98, respectively (p < 0.001); and FFM r (2) values were 0.87, 0.82, 0.99, respectively (p < 0.001). BIA and DXA measurements of body composition exhibit a high relative agreement in the study group of normo-hydrated obese subjects. BIA tends to overestimate FFM, but this effect is reduced along with the weight loss during the follow-up. Under the stable hydration, the BIA method may be useful as an alternative to DXA in a selected clinical setting when repeated comparisons of body composition are required.

Savastano S; Belfiore A; Di Somma C; Mauriello C; Rossi A; Pizza G; De Rosa A; Prestieri G; Angrisani L; Colao A

2010-03-01

269

m-[125I]iodoaniline: a useful reagent for radiolabeling biotin  

International Nuclear Information System (INIS)

Biotinyl-m-[125I]iodoanilide (BIA) was synthesized by coupling biotin to m-[125I]iodoaniline via a mixed anhydride reaction. m-[125I]Iodoaniline was produced from the tin precursor, which was prepared using a palladium catalyzed reaction of hexabutylditin with m-bromoaniline. The radioiodinated BIA derivative is characterized by a stable amide and/or intact ureido group on the biotin molecule, it may thus be a useful carrier for targeting radionuclides to avidin-conjugated antibodies previously localized on tumors. (author).

1992-01-01

270

Comparison of body composition methods in overweight and obese Brazilian women Comparação de métodos da composição corporal em mulheres brasileiras com sobrepeso e obesidade  

Directory of Open Access Journals (Sweden)

Full Text Available OBJECTIVE: The purpose of this study was to compare skinfold thickness (SKF) and bioelectrical impedance analysis (BIA) of body composition using three different equations against dual-energy X-ray absorptiometry (DXA) in overweight and obese Brazilian women. SUBJECTS AND METHOD: Thirty-four women (age 43.8 ± 10.9 years; body mass index [BMI] 32.1 ± 4.3 kg/m²) had percentage body fat (BF%), fat mass (FM) and fat-free mass (FFM) estimated by DXA, SKF and BIA (BIA-man: manufacturer's equation; and predictive obesity-specific equations of Segal and of Gray). Regression analysis, Bland-Altman plot analysis and intra-class correlation coefficient (ICC) were used to compare methods. RESULTS: Absolute agreement between DXA and BIA-man was poor for all measures of body composition (BF% -6.8% ± 3.7%, FM -3.1 ± 3.6 kg, FFM 5.7 ± 2.8 kg). BIA-Segal equation showed good absolute agreement with DXA for BF% (1.5% ± 1.5%), FM (1.0 ± 3.2 kg) and FFM (1.5 ± 2.6 kg), albeit the limits of agreement were wide. BIA-Gray equation showed good absolute agreement with DXA for FM (2.3 ± 4.1 kg), and smaller biases for BF% (0.05% ± 4.4%) and FFM (0.2 ± 2.9 kg), although wide limits of agreement. BIA-Gray and DXA showed the highest ICC among the pairs of methods. A good absolute agreement was observed between DXA and SKF for BF% (-2.3% ± 5.8%), FM (0.09 ± 4.7 kg), and FFM (2.4 ± 4.4 kg), although limits of agreement were wider and ICC between DXA and SKF for BF% indicated poor degree of reproducibility. CONCLUSION: These findings show that both BIA-Segal and BIA-Gray equations are suitable for BF%, FM and FFM estimations in overweight and obese women.OBJETIVO: Verificar a concordância dos métodos de impedância bioelétrica (BIA) usando três equações diferentes, e medida das pregas cutâneas (PC) com absorciometria de raios-X de dupla energia (DEXA), para análise da composição corporal de mulheres com sobrepeso e obesidade. SUJEITOS E MÉTODOS: Em 34 mulheres (43,8 ± 10.9 anos; índice de massa corporal [IMC] 32,1 ± 4,3 kg/m²) foram avaliados: percentual de gordura total (%GT), massa gorda (MG) e massa magra (MM) por DEXA, PC, BIA-Fab (equação do fabricante), BIA-Segal e BIA-Gray (equações para obesidade). Foram utilizados: análise de regressão, método de Bland-Altman e coeficiente de correlação intraclasse (CCI). RESULTADOS: A concordância absoluta entre DEXA e BIA-Fab foi fraca para todas as medidas (BF% -6,8% ± 3,7%, FM -3,1 ± 3,6 kg, FFM 5,7 ± 2,8 kg). BIA-Segal apresentou boa concordância absoluta com DEXA para %GT (1,5% ± 1,5%), MG (1,0 ± 3,2 kg) e MM (1,5 ± 2,6 kg), mas com amplos limites de concordância. BIA-Gray teve boa concordância absoluta com DEXA para MG (2,3 ± 4,1 kg) e pequenos vieses para %GT (0,05% ± 4,4%) e MM (0,2 ± 2,9 kg), mas com amplos limites de concordância. BIA-Gray e DEXA tiveram maior CCI entre métodos. Houve boa concordância absoluta entre DEXA e PC para %GT (-2,3% ± 5,8%), MG (0,09 ± 4,7 kg) e MM (2,4 ± 4,4 kg), mas com amplos limites de concordância e pouca reprodutibilidade no CCI, entre DEXA e PC para %GT. CONCLUSÃO: A BIA, utilizando equação específica para obesidade, foi o método que melhor concordou com DEXA, para estimar %GT, MG e MM em mulheres com sobrepeso e obesidade.

Valeria Bender Braulio; Valéria Cristina Soares Furtado; Maria das Graças Silveira; Maria Helena Fonseca; José Egídio Oliveira

2010-01-01

271

GESTIS-STAUB-EX - combustion and explosion characteristics of dusts on the internet; GESTIS-STAUB-EX - Brenn- und Explosionskenngroessen von Staeuben im Internet  

Energy Technology Data Exchange (ETDEWEB)

Since 1980, the Berufsgenossenschaftliches Institut fuer Arbeitssicherheit - BIA has been publishing combustion and explosion characteristics of dusts in tabular form. The data were determined by various test bodies using harmonised methods and test facilities. At the time being, combustion and explosion data for more than 4000 dusts are available. From February 2001 these data may be accessed via Internet, address: www.hvbg.de/BIA/GESTIS-STAUB-EX. To use the data correctly, it is essential to have knowledge of the different factors - e.g. fineness and humidity of the dusts - which have an effect on the characteristics, and to observe the limits of applicability. (orig.)

Beck, H. [Berufsgenossenschaftliches Inst. fuer Arbeitssicherheit, St. Augustin (Germany)

2001-03-01

272

Radiochemical investigations of chalcogenide films. VIII. Chemical state of bismuth and its preconcentration from the thermal springs at cheleken by thin-layer copper(II) sulfide  

International Nuclear Information System (INIS)

The state of bismuth in Cheleken water has been studied by thermodynamic calculations, paper electrophoresis, and a distribution method. The radioactive tracers used were 207Bi and 212Pb. It has been shown that regardless of the form of bismuth introduced into the water, the system of complexes, among which the principal species are BiA4- and Na2BiA6-, where A denotes a halide ion, is inert. The use of thin-layer copper(II) sulfide and x-ray fluorescence analysis made it possible to evaluate the concentration of bismuth in Cheleken water (n x 10-8 to n x 10-9 M).

1983-01-01

273

Accuracy of segmental multi-frequency bioelectrical impedance analysis for assessing whole-body and appendicular fat mass and lean soft tissue mass in frail women aged 75 years and older.  

UK PubMed Central (United Kingdom)

BACKGROUND/OBJECTIVE: We aimed to examine the accuracy of segmental multi-frequency bioelectrical impedance analysis (SMF-BIA) for the assessment of whole-body and appendicular fat mass (FM) and lean soft tissue mass (LM) in frail older women, using dual-energy X-ray absorptiometry (DXA) as a reference method. SUBJECTS/METHODS: All 129 community-dwelling Japanese frail older women with a mean age of 80.9 years (range, 75-89 years) from the Frailty Intervention Trial were recruited. The agreements between SMF-BIA and DXA for whole-body and appendicular body composition were assessed using simple linear regression and Bland-Altman analysis. RESULTS: High coefficients of determination (R(2)) for whole-body FM (R(2)=0.94, s.e. of estimate (SEE)=1.2 kg), whole-body LM (R(2)=0.85, SEE=1.4 kg), and appendicular FM (R(2)=0.82, SEE=1.1 kg) were observed between SMF-BIA and DXA. The R(2) coefficient for appendicular LM was moderate (R(2)=0.76, SEE=0.8 kg). Bland-Altman plots demonstrated that there was systematic (constant) bias (that is, DXA minus SMF-BIA) with overestimation of whole-body FM (bias=-1.2 kg, 95% confidence interval (CI)=-1.5 to -0.1) and underestimation of whole-body LM (bias=2.1 kg, 95% CI=1.8-2.3) by SMF-BIA. Similar, the appendicular measurements also demonstrated systematic bias with overestimation of appendicular FM (bias=-0.3 kg, 95% CI=-0.5 to -0.1) and underestimation of whole-body LM (bias=1.5 kg, 95% CI=1.4-1.7) by SMF-BIA. In addition, the individual level accuracy demonstrated a non-proportional bias for whole-body LM (r=0.08, P=0.338) and appendicular FM (r=0.07, P=0.413). CONCLUSIONS: SMF-BIA had acceptable accuracy for the estimation of whole-body and appendicular FM and LM in frail older women, although SMF-BIA underestimated LM and overestimated FM relative to DXA.

Kim M; Kim H

2013-04-01

274

LOOKING FOR A ROAD TO GET OUT OF POVERTY: IS THE CURRENT ALLOCATION OF PUBLIC SPENDING ON EDUCATION IN COLOMBIA HELPING?  

Scientific Electronic Library Online (English)

Full Text Available Abstract in english This paper presents a methodology to explore the impact on poverty of the public spending on education. The methodology consists of two approaches: Benefit Incidence Analysis (BIA) and behavioral approach. BIA considers the cost and use of the educational service, and the distribution of the benefits among groups of income. Regarding the behavioral approach, we use a Probit model of schooling attendance, in order to determine the influence of public spending on the probab (more) ility for the poor to attend the school. As a complement, a measurement of targeting errors in the allocation of public spending is included in the methodology.

ZULUAGA DÍAZ, BLANCA CECILIA; SCHOKKAERT, ERIK

2004-12-01

275

Looking for a road to get out of poverty. Is the current allocation of public spending on education in Colombia helping?  

Directory of Open Access Journals (Sweden)

Full Text Available This paper presents a methodology to explore the impact on poverty of the public spending on education. The methodology consists of two approaches: Benefit Incidence Analysis (BIA) and behavioral approach. BIA considers the cost and use of the educational service, and the distribution of the benefits among groups of income. Regarding the behavioral approach, we use a Probit model of schooling attendance, in order to determine the influence of public spending on the probability for the poor to attend the school. As a complement, a measurement of targeting errors in the allocation of public spending is included in the methodology.

Blanca Cecilia Zuluaga Díaz; Erick Schokkaert

2004-01-01

276

M-[[sup 125]I]iodoaniline: a useful reagent for radiolabeling biotin  

Energy Technology Data Exchange (ETDEWEB)

Biotinyl-m-[[sup 125]I]iodoanilide (BIA) was synthesized by coupling biotin to m-[[sup 125]I]iodoaniline via a mixed anhydride reaction. m-[[sup 125]I]Iodoaniline was produced from the tin precursor, which was prepared using a palladium catalyzed reaction of hexabutylditin with m-bromoaniline. The radioiodinated BIA derivative is characterized by a stable amide and/or intact ureido group on the biotin molecule, it may thus be a useful carrier for targeting radionuclides to avidin-conjugated antibodies previously localized on tumors. (author).

Khawli, L.A.; Kassis, A.I. (Harvard Medical School, Boston, MA (United States))

1992-04-01

277

Estimativa da massa muscular esquelética em mulheres idosas: validade da impedância bioelétrica Validity of bioelectrical impedance analysis for the estimation of skeletal muscle mass in elderly women  

Directory of Open Access Journals (Sweden)

Full Text Available O presente estudo tem como objetivos: a) verificar a concordância entre os métodos da impedância bioelétrica (BIA) e da absortometria radiológica de dupla energia (DXA) para a estimativa da massa muscular esquelética (MME); e b) analisar o poder preditivo de variáveis antropométricas e da BIA para a predição da MME em idosas. Foram avaliadas 120 mulheres (60 a 81 anos), residentes na região Sul do Brasil. Mensuraram-se as variáveis antropométricas (massa corporal e estatura); a resistência e hidratação dos tecidos livres de gordura foram medidas pela técnica da BIA tetrapolar (Biodinamics - BF-310), e pela DXA de corpo inteiro (Lunar Prodigy DF + 14319 Radiation e software 7.52.002 DPX-L). A diferença entre os métodos foi verificada pelo teste t pareado, análise dos resíduos e o coeficiente de correlação. O valor preditivo das variáveis antropométricas e de BIA foi verificado pela regressão linear múltipla, adotando nível de significância de p 0,01). Observou-se que a BIA subestimou em média 0,8kg (IC95%: -3,7; 2,0kg) a MME, quando comparada com a DXA. Foi observada alta correlação entre os métodos (r² = 0,75; p The objectives of the present study were: a) to determine the agreement between bioelectrical impedance analysis (BIA) and dual-energy X-ray absorptiometry (DXA) for the estimation of skeletal muscle mass (SMM), and b) to analyze the predictive power of anthropometric variables and BIA for the prediction of SMM in elderly women. A total of 120 women (60 to 81 years), living in the southern region of Brazil, were studied. Anthropometric variables (body weight and height) were measured. Resistance and hydration of fat-free tissues were measured by tetrapolar BIA (Biodynamics, BF-310) and by whole-body DXA (Lunar Prodigy DF + 14319 Radiation and DPX-L software, version 7.52.002). Differences between methods were determined using the paired t-test, analysis of residuals and correlation coefficient. The predictive value of the anthropometric variables and BIA was evaluated by multiple linear regression, adopting a level of significance of p < 0.05. No significant difference in the estimation of SMM was observed between methods (p < 0.01). BIA underestimated SMM in mean of 0.8 kg (95%CI: -3.7; 2.0 kg) when compared to DXA. Correlation between methods was high (r² = 0.75; p < 0.01). Regression analysis demonstrated that the ratio between the square of height and resistance (HEIGHT²/R) explained 80% of the variation in SMM when adjusted to body weight and age, regardless of body fat, lean tissue hydration or body mass index. Thus, the BIA equation tested here is a valid tool for the estimation of SMM in elderly women and its value is best predicted by the regression model including HEIGHT²/R adjusted to body weight and age.

Cassiano Ricardo Rech; Eline Salomons; Luiz Rodrigo Augustemak de Lima; Edio Luiz Petroski; Maria Fátima Glaner

2010-01-01

278

Utilização da impedância bioelétrica para estimativa da massa muscular esquelética em homens idosos Use of bioelectrical impedance for the estimation of skeletal muscle mass in elderly men  

Directory of Open Access Journals (Sweden)

Full Text Available O presente estudo tem como objetivos: a) verificar a concordância entre os métodos da impedância bioelétrica (BIA) e da absortometria radiológica de dupla energia (DEXA), para a estimativa da massa muscular esquelética (MME); b) analisar o poder preditivo das variáveis antropométricas e de BIA para predição da MME em idosos. Foram avaliados 60 homens idosos (61 a 80 anos), residentes na região Sul do Brasil. Mensuraram-se as variáveis antropométricas (massa corporal e estatura), as variáveis de resistência e hidratação dos tecidos livres de gordura foram medidas pela técnica da BIA tetrapolar (Biodinamics - BF-310), realizou-se também um scan de corpo inteiro através da DEXA (LUNAR PRODIGY DF + 14319 Radiation e software 7.52.002 DPX-L). A diferença entre os métodos foi verificada pelo teste “t”, análise dos resíduos e o coeficiente de correlação. O valor preditivo das variáveis antropométricas e de BIA foi verificado pela regressão Linear Múltipla. Observou-se que a BIA superestimou em média 0,6 kg (dp= 1,59) a MME, quando comparada com a DEXA, contudo não houve diferença estatística (pThe aim of the present study was twofold: a) to determine the agreement between bioelectrical impedance analysis (BIA) and dual energy X-ray absorptiometry (DEXA) for the estimation of skeletal muscle mass (SMM), and b) to analyze the predictive power of anthropometric variables and BIA for the prediction of SMM in the elderly. Sixty elderly men (61 to 80 years) from the southern region of Brazil were studied. Anthropometric variables (body weight and height) were measured, the resistance and hydration of fat-free tissues variables were determined by tetrapolar BIA (BF-310, Biodynamics). A whole body DEXA scan was also performed (Lunar Prodigy DF + 14319 Radiation and 7.52.002 DPX-L software). Differences between methods were analyzed using the t-test, analysis of residues and correlation coefficient. The predictive value of the anthropometric variables and BIA was evaluated by multiple linear regression. BIA overestimated SMM on average by 0.60 kg (sd=1.59) when compared to DEXA, however, no statistical difference was observed (p>0.05). There was a strong correlation between methods (r=0.90; p<0.01). Regression analysis demonstrated that the Ht²/R variable explained 86% of the variation in SMM when adjusted for body weight and age, and this relationship did not depend on body fat, hydration of fat-free tissues or BMI. Thus, BIA as tested here is a valid method for the estimation of SMM in elderly men and its values can be best predicted using the regression model proposed, which included Ht²/R adjusted for body weight and age.

Luiz Rodrigo Augustemak de Lima; Cassiano Ricardo Rech; Edio Luiz Petroski

2008-01-01

279

Análise comparativa de métodos de avaliação da composição corporal em homens sadios e em pacientes com doença pulmonar obstrutiva crônica: antropometria, impedância bioelétrica e absortiometria de raios-X de dupla energia  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese O trabalho teve, como objetivo principal, verificar se a antropometria (ANT) e a impedância bioelétrica (BIA) fornecem resultados concordantes com os obtidos pela absortiometria de raios-X de dupla energia (DXA), quanto à massa (MG) e à porcentagem de gordura (%GC), à massa livre de gordura corporal (MLG) e ao índice de MLG (IMLG= MLG/estatura²), em indivíduos adultos (³ 50 anos), do sexo masculino, sadios (n=23) e em pacientes com doença pulmonar obstrutiva cr? (more) ?nica (DPOC) (n=24). As comparações entre as técnicas de composição do corpo foram feitas utilizando ANOVA por medidas repetidas; para análise de concordância, utilizou-se o procedimento de Bland & Altman. Resultados e Conclusões: 1) valores obtidos no grupo sadio foram significantemente diferentes dos observados no grupo com DPOC; 2) não foram observadas diferenças significantes, nos indivíduos sadios, entre DXA ´ BIA e entre DXA ´ ANT; em DPOC, a comparação entre DXA ´ BIA revelou, para BIA, valores estatisticamente maiores para MG e %GC e menores para MLG e IMLG; na comparação DXA ´ ANT, não houve diferenças significantes entre as variáveis; 3) a aplicação do teste de Bland & Altman, em ambos os grupos, mostrou falta de concordância na comparação da BIA com DXA e, também, da ANT com DXA; verificou-se, também, superestimação da gordura corporal e subestimação da MLG pela BIA, em relação à DXA. Abstract in english Comparative analysis of body composition assessment methods in healthy men and in chronic obstructive pulmonary disease patients: anthropometry, bioelectrical impedance and dual-energy X-ray absorptiometry. The aim of this study was to examine the agreement between the results of body fat (BF and BF%), fat-free mass (FFM) and FFM index (FFMI= FFM/height²) as estimated by skinfold anthropometry (ANT), bioelectrical impedance (BIA) and dual-energy X-ray absorptiometry (DXA (more) ) in two groups of men (³ 50 y), one comprising healthy individuals (n=23) and the other, patients with chronic obstructive pulmonary disease (COPD) (n=24). Comparisons between body composition techniques were done by repeated measures ANOVA; the Bland & Altman procedure was used to analyse agreement. Results and Conclusions: 1) comparison between healthy and COPD groups showed significant differences between all studied variables; 2) in the healthy group, values for BF, BF% , FFM and FFMI were not significantly different when BIA or ANT was compared to DXA; however, in COPD, values for BF and BF% were significantly higher and for FFM and FFMI significantly lower when BIA was compared to DXA; in contrast, no differences were shown between values for these variables when ANT was compared with DXA; 3) Bland & Altman test, in both groups, showed no agreement between BIA and DXA and between ANT and DXA; it was also shown that body fat was overestimated and fat free mass underestimated by BIA in relation to DXA.

Forte Freitas, Ismael; Rupp de Paiva, Sérgio Alberto; Godoy, Irma; Smaili Santos, Suhaila Mahmoud; Campana, Álvaro Oscar

2005-06-01

280

Understanding vulnerability for depression from a cognitive neuroscience perspective : a reappraisal of attentional factors and a new conceptual framework  

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We propose a framework to understand increases in vulnerability for depression after recurrent episodes that links attention processes and schema activation to negative mood states, by integrating cognitive and neurobiological findings. Depression is characterized by a mood-congruent attentional bia...

De Raedt, Rudi; Koster, Ernst

 
 
 
 
281

78 FR 31518 - Endangered and Threatened Species; Take of Anadromous Fish  

Science.gov (United States)

...Wildlife (ODFW), Washington Department of Fish and Wildlife (WDFW), and U.S. Bureau of Indian Affairs for ESA section 10...that the requirements are met, permits will be issued to ODFW, WDFW, and the BIA for the purpose of carrying out the hatchery...

2013-05-24

282

Review of Educational Activities, Bureau of Indian Affairs, Part I.  

Science.gov (United States)

The document reports an audit review made of educational activities within the Bureau of Indian Affairs (BIA) area offices in Anadarko and Muskogee, Oklahoma; Gallup, New Mexico; Juneau, Alaska; and Phonenix, Arizona. The field work, completed in 1967, was designed to (1) compile financial information to correlate with measures of output, (2)…

Department of the Interior, Washington, DC.

283

Biosensor immunoassay for the detection of eight sulfonamides in chicken serum  

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A monoclonal antibody (MAb) raised against sulfamethazine (21C7) was applied in an optical biosensor (Biacore Q) to develop a rapid biosensor immunoassay (BIA) for the detection of several sulfonamides in chicken serum. The performance of this MAb was compared with two polyclonal antibodies (PAbs) r...

Haasnoot, W.; Bienenmann-Ploum, M.; Kohen, F.

284

The Mating Type Locus (MAT) and Sexual Reproduction of Cryptococcus heveanensis: Insights into the Evolution of Sex and Sex-Determining Chromosomal Regions in Fungi  

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Mating in basidiomycetous fungi is often controlled by two unlinked, multiallelic loci encoding homeodomain transcription factors or pheromones/pheromone receptors. In contrast to this tetrapolar organization, Cryptococcus neoformans/Cryptococcus gattii have a bipolar mating system, and a single bia...

Metin, Banu; Findley, Keisha; Heitman, Joseph

285

Natural infections of small mammals with blood parasites on the borderland of boreal and temperate forest zones  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Blood parasites of small mammals living in Bia?owie?a Forest (eastern Poland) were investigated between 1996 and 2002. The following haemoparasite species were found: Trypanosoma (Herpetosoma) evotomys in bank vole Clethrionomys glareolus and root vole Microtus oeconomus; Babesia microti in root vol...

Karbowiak, Grzegorz; Rychlik, Leszek; Nowakowski, Wojciech; Wita, Irena

286

The Navajo and Hopi's History of Inequitable Mining Leases.  

Science.gov (United States)

The Council on Economic Priorities charged the BIA with violating its "moral obligations of highest responsibility and trust," because it approved coal leases with low royalty rates on the basis of weak environmental research. This article implies that tribes are more likely to receive equitable leases by negotiating directly with companies than…

Barry, Tom

1979-01-01

287

77 FR 63850 - Rate Adjustments for Indian Irrigation Projects  

Science.gov (United States)

...unless we state otherwise in writing. Assessable acre means lands designated by us to...of irrigation service. (See total assessable acres.) BIA means the Bureau of Indian...that owns or leases land within the assessable acreage of one of our irrigation...

2012-10-17

288

The comparative evaluation of patients' body dry weight under hemodialysis using two methods: Bioelectrical impedance analysis and conventional method.  

UK PubMed Central (United Kingdom)

BACKGROUND: Dry weight (DW) is an important concept related to patients undergoing hemodialysis. Conventional method seems to be time consuming and operator dependent. Bio impedance analysis (BIA) is a new and simple method reported to be an accurate way for estimating DW. In this study, we aimed to compare the conventional estimation of DW with measuring DW by BIA. MATERIALS AND METHODS: This study involved 130 uremic patients, performed in Isfahan, Iran. DW was calculated by both conventional (CDW) and BIA (BIADW) method and results were compared based on different grouping factors including sex, underlying cause of renal failure (RF) (diabetic RF and non-diabetic RF), body mass index (BMI) status, and sessions of hemodialysis. We also calculated the difference between DWs of 2 methods (DW diff = CDW-BIADW). RESULTS: The mean of BIADW was significantly lower than CDW (57.20 ± 1.82 vs 59.36 ± 1.77, P value < 0.001). After grouping cases according to the underlying cause, BMI, sex, and dialysis sessions BIADW was significantly lower than CDW. CONCLUSION: Based on the combination of problems with CDW measurement which are corrected by BIA, and more clinical reliability of CDW, we concluded that although conventional method is a time-consuming and operator-dependent way to assess DW, DW could be estimated by combining both of these methods by finding the mathematic correlation between these methods.

Alijanian N; Naini AE; Shahidi S; Liaghat L; Samani RR

2012-10-01

289

How to do (or not to do) ... a benefit incidence analysis.  

UK PubMed Central (United Kingdom)

Benefit incidence analysis (BIA) considers who (in terms of socio-economic groups) receive what benefit from using health services. While traditionally BIA has focused on only publicly funded health services, to assess whether or not public subsidies are 'pro-poor', the same methodological approach can be used to assess how well the overall health system is performing in terms of the distribution of service benefits. This is becoming increasingly important in the context of the growing emphasis on promoting universal health systems. To conduct a BIA, a household survey dataset that incorporates both information on health service utilization and some measure of socio-economic status is required. The other core data requirement is unit costs of different types of health service. When utilization rates are combined with unit costs for different health services, the distribution of benefits from using services, expressed in monetary terms, can be estimated and compared with the distribution of the need for health care. This paper aims to provide an introduction to the methods used in the 'traditional' public sector BIA, and how the same methods can be applied to undertake an assessment of the whole health system. We consider what data are required, potential sources of data, deficiencies in data frequently available in low- and middle-income countries, and how these data should be analysed.

McIntyre D; Ataguba JE

2011-03-01

290

76 FR 19772 - Environmental Impacts Statements; Notice of Availability  

Science.gov (United States)

...National Monument Management Plan Amendment, Garfield County, UT, Review Period Ends: 05/09/2011, Contact: Susan Baughman 435-865-3703. EIS No. 20110106, Draft EIS, BIA, NM, Pueblo of Jemez 70.277 Arce Fee- To- Trust Transfer and...

2011-04-08

291

Different Techniques For Body Composition Assessment  

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The inter-relationships and alter nativity of body composition variables derived from simple anthropometry [BMI and Skin Folds (SFs) prediction equations] and Bioelectrical Impedance Analysis (BIA) with dual energy x-ray (DXA) of healthy sixty nine children (37 boys and 32 girls) aged 9.24±1.73 ...

Nayera E. Hassan; Sahar A. El-Masry; Nadia L. Soliman; Mona M. EL-Batran

292

A Critical Systematic Review of Budget Impact Analyses on Drugs in the EU Countries.  

UK PubMed Central (United Kingdom)

CONCLUSIONS: Our review confirmed that the BIA is not yet a well-established technique in the literature and many published studies still fail to reach an acceptable quality. In particular, BIAs funded by pharmaceutical companies appear to be tailored to show short-term savings induced by new, highly priced products.

van de Vooren K; Duranti S; Curto A; Garattini L

2013-10-01

293

Validity of bioelectrical impedance analysis to assess fat-free mass in head and neck cancer patients: an exploratory study.  

UK PubMed Central (United Kingdom)

BACKGROUND: We aimed to validate bioelectrical impedance analysis (BIA) using the Geneva equation for fat-free mass (FFM) in head and neck cancer (HNC) patients. METHODS: In 24 HNC patients, agreement between BIA (FFMBIA ) and dual energy x-ray absorptiometry (FFMDXA ) one week before (T0 ), one month (T1 ) and four months (T2 ) after cancer treatment was analyzed. RESULTS: FFMBIA did not differ from FFMDXA (mean difference 0.71±1.9, 0.30±1.9 and 0.02±2.1 kg) at any time point. Only at T0 , mean FFM correlated to the difference between FFMDXA and FFMBIA (r=0.48, P=0.017). Limits of agreement were 3.8, 3.7 and 4.1 kg respectively. Concordance Correlation Coefficients were 0.98 at all time points. CONCLUSIONS: BIA may be used to assess FFM with reasonable validity based on mean-level comparisons, but differences between BIA and DXA may vary by about 4 kg in an individual patient. These results require confirmation in a larger sample of HNC patients. Head Neck, 2013.

Jager-Wittenaar H; Dijkstra PU; Earthman CP; Krijnen WP; Langendijk JA; van der Laan BF; Pruim J; Roodenburg JL

2013-04-01

294

Kalman-Filter-Based Orientation Determination Using Inertial/Magnetic Sensors: Observability Analysis and Performance Evaluation  

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In this paper we present a quaternion-based Extended Kalman Filter (EKF) for estimating the three-dimensional orientation of a rigid body. The EKF exploits the measurements from an Inertial Measurement Unit (IMU) that is integrated with a tri-axial magnetic sensor. Magnetic disturbances and gyro bia...

Angelo Maria Sabatini

295

A Multivariate Regression Approach to Adjust AATSR Sea Surface Temperature to In Situ Measurements  

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The Advanced Along-Track Scanning Radiometer (AATSR) onboard Envisat is designed to provide very accurate measurements of sea surface temperature (SST). Using colocated in situ drifting buoys, a dynamical matchup database (MDB) is used to assess the AATSR-derived SST products more precisely. SST bia...

Tandeo Pierre; Autret Emmanuelle; Piolle Jean-francois; Tournadre Jean; Ailliot Pierre

296

Benefit-incidence analysis: are government health expenditures more pro-rich than we think?  

Science.gov (United States)

Authors of benefit-incidence analyses (BIA) have to impute subsidies using assumptions about the relationship between unobserved subsidies 'captured' by the household and what can be observed at the household and aggregate levels. This paper shows that one of the two assumptions used in BIA studies to date will necessarily produce a more pro-rich (or less pro-poor) picture of government health spending than the other, depending on whether utilization is more pro-rich or pro-poor than fees paid to public providers. Both assumptions have their disadvantages, and the paper suggests a couple of alternatives that explicitly link fees paid to the costliness of care. It shows that in the most likely case where fees are distributed in a more pro-rich fashion than utilization, the two traditional assumptions will produce less pro-rich distributions of subsidies than the two new alternatives. Also considered are three complications that arise in BIA studies, including factoring in social health insurance. The paper's theoretical results are illustrated with an empirical BIA for Vietnam. PMID:21394820

Wagstaff, Adam

2011-03-10

297

BIOELECTRICAL IMPEDANCE VECTOR ANALYSIS IDENTIFIES SARCOPENIA IN NURSING HOME RESIDENTS  

Science.gov (United States)

Loss of muscle mass and water shifts between body compartments are contributing factors to frailty in the elderly. The body composition changes are especially pronounced in institutionalized elderly. We investigated the ability of single-frequency bioelectrical impedance analysis (BIA) to identify b...

298

ELODIE metallicity-biased search for transiting Hot Jupiters II. A very hot Jupiter transiting the bright K star HD189733  

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Among the 160 known exoplanets, mainly detected in large radial-velocity surveys, only 8 have a characterization of their actual mass and radius thanks to the two complementary methods of detection: radial velocities and photometric transit. We started in March 2004 an exoplanet-search programme bia...

Bouchy, Francois; Udry, Stephane; Mayor, Michel; Moutou, Claire; Pont, Frederic; Iribarne, Nicolas; Da Silva, Ronaldo

299

Obraz ci??kiej enteropatii wysi?kowej w przebiegu choroby Le?niowskiego-Crohna u 6-letniego ch?opca - opis przypadku  

Directory of Open Access Journals (Sweden)

Full Text Available W pracy przedstawiono trudno?ci diagnostyczne i terapeutyczne dotycz?ce przypadku 6-letniego ch?opca z chorob? Le?niowskiego-Crohna, o nag?ym, nietypowym przebiegu z zespo?em jelitowej utraty bia?ka oraz wyst?pieniem wielu powa?nych powik?a? w trakcie 5,5-miesi?cznej hospitalizacji.

El?bieta Czkwianianc; Alina Durko; Izabela P?aneta-Ma?ecka; Ewa Ma?ecka-Panas

2007-01-01

300

25 CFR 1000.403 - How can a person or group appeal a decision or contest an action related to a program operated by...  

Science.gov (United States)

A person or group who is aggrieved by an action of a Tribe/Consortium with respect to programs that are provided by the Tribe/Consortium under an AFA must follow Tribal administrative procedures. (b) Non-BIA programs. Procedures will vary depending on the...

2010-04-01

 
 
 
 
301

Studies of plasma potential with emissive probes in the low temperature plasma experiment NJORD  

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In this thesis, the concept of an emissive probe has been used to obtain the plasma potential in the low temperature plasma experiment NJORD. An emissive probe is a probe concept in which a wire is heated strong enough to emit a Richardson current. The probe is then swept through several voltage bia...

Schregel, Christian-Georg

302

Study and classification of the abdominal adiposity throughout the application of the two-dimensional predictive equation Garaulet et al., in the clinical practice/ Estudio y clasificación de la adiposidad abdominal mediante la aplicación de la ecuación predictiva bidimensional de Garaulet et al., en la práctica clínica  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Introducción: El exceso de tejido adiposo abdominal visceral es una de las mayores preocupaciones en la obesidad y su tratamiento clínico. Objetivo: Aplicar la ecuación predictiva bidimensional propuesta por Garaulet et al., para determinar la distribución de la grasa abdominal y comparar los resultados con la composición corporal obtenida mediante el análisis de impedancia bioeléctrica multi-frecuencia (M-BIA). Sujetos/métodos: Estudiamos a 230 mujeres a las que (more) se sometió a antropometría y M-BIA. Se aplicó la ecuación predicitiva. Se realizaron correlaciones lineales multivariadas y parciales controlando el IMC y el % de grasa corporal, utilizando SPSS 15.0 con significación estadística P Abstract in english Introduction: The excess of visceral abdominal adipose tissue is one of the major concerns in obesity and its clinical treatment. Objective: To apply the two-dimensional predictive equation proposed by Garaulet et al. to determine the abdominal fat distribution and to compare the results with the body composition obtained by multi-frequency bioelectrical impedance analysis (M-BIA). Subjects/methods: We studied 230 women, who underwent anthropometry and M-BIA. The predicti (more) ve equation was applied. Multivariate lineal and partial correlation analyses were performed with control for BMI and % body fat, using SPSS 15.0 with statistical significance P

Piernas Sánchez, C. M.ª; Morales Falo, E. M.ª; Zamora Navarro, S.; Garaulet Aza, M.

2010-04-01

303

Polychlorinated dibenzodioxins and -furans at the workplace. Polychlorierte Dibenzodioxine und -furane an Arbeitsplaetzen  

Energy Technology Data Exchange (ETDEWEB)

In cooperation with the Berufsgenossenschaften (accident prevention and insurance institutions in industry) and the accident insurance institutions of the communes the Berufsgenossenschaftliches Institut fuer Arbeitssicherheit - BIA carried out measurements to determine workplace exposure to polychlorinated dibenzodioxins and -furans. First results obtained in the field of garbage incineration and non-iron metal recycling are now available. (orig.)

Stockmann, R. (Berufsgenossenschaftliches Inst. fuer Arbeitssicherheit (BIA), Sankt Augustin (Germany)); Hahn, J.U. (Berufsgenossenschaftliches Inst. fuer Arbeitssicherheit (BIA), Sankt Augustin (Germany)); Lichtenstein, N. (Berufsgenossenschaftliches Inst. fuer Arbeitssicherheit (BIA), Sankt Augustin (Germany)); Neumann, H.D. (Gemeindeunfallversicherungsverband Westfalen-Lippe, Muenster (Germany)); Schick, W. (Edel- und Unedelmetall-Berufsgenossenschaft, Stuttgart (Germany))

1993-10-01

304

Biosíntesis de alcaloides bencilisoquinolínicos  

Directory of Open Access Journals (Sweden)

Full Text Available Benzylisoquinoline alkaloid biosynthesis. The benzylisoquinoline alkaloids (BIA) are specialized metabolites with an ancient phylogeneticdistribution, but still preserved in modern clades. Some of them, such as morphine, sanguinerine or berberine, are important for modernmedicine. This review discusses the highlights of the current state of the biosynthesis of BIA. There have been studies that show thebiosynthesis of 22 of these nitrogenous metabolites. In their formation there are 43 enzymes grouped into oxidoreductases, transferasesand lyases, which in some cases represent atypical examples of the manner in which the secondary metabolism diversification wasoriginated. Two of these examples are the cytochrome proteins P450 (P450), with catalytic activities for ABI route, or the norcoclaurinesynthase enzyme (NCS), which share substantial identity with defense allergenic proteins. Likewise, there are genetic advances thathave produced the characterization of 30 enzymes, allowing knowledge of regulatory processes. Another interesting aspect is thecompartmentation of the biosynthesis sites and accumulation of BIA, since in several cases they are spatially separated and in differentspecies, or in the same species several types of cells may be involved. This has suggested intra and intercellular transport of alkaloids,precursors and enzymes, and it has been documented berberine transport between the cytoplasm and the vacuoles of storage. The picturefor the biosynthesis of BIA has been constructed with exemplary studies of alkaloids with pharmacological importance.

Iván De-La-Cruz Chacón; Alma Rosa González-Esquinca; Christian Anabí Riley-Saldaña

2012-01-01

305

Blue ice areas formed by an interplay between ice velocity and SMB  

Science.gov (United States)

Blue ice areas (BIAs) cover around 1% of the East Antarctic ice sheet and are visual evidence of long-term ablation. However, the physical processes that drive the presence of these BIAs are poorly understood. Here, we combine high-resolution (5.5 km) maps of surface mass balance (SMB) and firn layer characteristics of East Antarctica, produced with the regional atmospheric climate model RACMO2, and knowledge of ice velocities, to describe the interplay between ice dynamics and SMB on the formation of blue ice. We show that blue ice typically forms in areas with small ablation such as in coastal Dronning Maud Land. In these regions, more snow is sublimated and/or eroded than is accumulated. Due to the locally low ice velocities (BIA, and the subsequent downstream build-up of the firn layer downstream of the BIA, is simulated to assess the sensitivity of these BIAs for positive feedback mechanisms. BIAs have a lower albedo, leading to higher near-surface temperatures and corresponding higher sublimation amounts. Also, a BIA surface is smoother, making it less prone for precipitating snow to stick to the surface. These mechanisms make a BIA to some extent self-sustaining.

Ligtenberg, Stefan; Lenaerts, Jan; van den Broeke, Michiel; Scambos, Ted

2013-04-01

306

Body composition in 18 to 88-year-old adults - comparison of multifrequency bioimpedance and dual-energy X-ray absorptiometry.  

UK PubMed Central (United Kingdom)

Objective: This study compared bioimpedance analysis (BIA) in the assessment of body composition with dual-energy X-ray absorptiometry (DXA) in 18-88 year-old adults. Design and Methods: Body composition of 882 adults was estimated by eight-polar BIA and DXA. In addition, estimates of lean mass, fat mass and percentage of fat were investigated across a range of age and leisure time physical activity (LTPA) groups. Results: Compared to DXA, larger lean masses (mean difference 2.9 and 1.6kg) and smaller fat masses (3.1 and 2.6kg) were estimated by BIA in both women and men, respectively. Differences between the methods' mean values were evident in all age and LTPA groups, except in the oldest men (over 70 years). Age, waist circumference, grip strength and LTPA explained 21% or less of the variance observed in the differences between methods. Conclusions: Compared to DXA, BIA provided systematically different body composition estimates throughout the adult age span with considerable amount of intraindividual variation. The differences between estimates may be related to the BIAs' algorithm or body geometry or composition of the population used in this study. Knowledge about the methodological limitations and device comparability is essential for researchers, clinicians and persons working in rehabilitation and sport centers.

Sillanpää E; Cheng S; Häkkinen K; Finni T; Walker S; Pesola A; Ahtiainen J; Stenroth L; Selänne H; Sipilä S

2013-07-01

307

Bioelectrical impedance analysis to estimate body composition in children and adolescents: a systematic review and evidence appraisal of validity, responsiveness, reliability and measurement error.  

UK PubMed Central (United Kingdom)

Bioelectrical impedance analysis (BIA) is a practical method to estimate percentage body fat (%BF). In this systematic review, we aimed to assess validity, responsiveness, reliability and measurement error of BIA methods in estimating %BF in children and adolescents.We searched for relevant studies in Pubmed, Embase and Cochrane through November 2012. Two reviewers independently screened titles and abstracts for inclusion, extracted data and rated methodological quality of the included studies. We performed a best evidence synthesis to synthesize the results, thereby excluding studies of poor quality. We included 50 published studies. Mean differences between BIA and reference methods (gold standard [criterion validity] and convergent measures of body composition [convergent validity]) were considerable and ranged from negative to positive values, resulting in conflicting evidence for criterion validity. We found strong evidence for a good reliability, i.e. (intra-class) correlations ?0.82. However, test-retest mean differences ranged from 7.5% to 13.4% of total %BF in the included study samples, indicating considerable measurement error. Our systematic review suggests that BIA is a practical method to estimate %BF in children and adolescents. However, validity and measurement error are not satisfactory.

Talma H; Chinapaw MJ; Bakker B; Hirasing RA; Terwee CB; Altenburg TM

2013-07-01

308

Effect of environmental factors on the biosynthesis of the neuro-excitatory amino acid ?-ODAP (?-N-oxalyl-L-?,?-diaminopropionic acid) in callus tissue of Lathyrus sativus.  

Science.gov (United States)

Habituated callus tissues derived from leaf explants of Lathyrus sativus L. (grass pea) were cultured under different environmental conditions such as drought, salinity and deficiency or oversupply of micronutrients. The biosynthesis of the neuro-excitatory ?-ODAP (?-N-oxalyl-L-?,?-diaminopropionic acid) was induced by feeding the precursor BIA, (?-isoxazolin-5-on-2-yl)-alanine, to those calli habituated under different stress conditions. Conversion of BIA into ?-ODAP was reduced by Zn(2+) at different levels of Fe(2+) supplements while excess of Fe(2+) enhanced it at different Zn(2+) levels in the media. The biosynthesis of ?-ODAP was increased by both oversupply and deficiency of Mn(2+) manganese while B(3+) as well as Co(2+) increased it significantly by oversupply. Al(3+) enhanced the conversion of BIA into ?-ODAP significantly in a concentration-dependent way. Cu(2+) also reduced the formation of ?-ODAP when increased in the media. Mo(6+) had no apparent effect. NaCl decreased the conversion of BIA into ?-ODAP proportionately with the increase in salinity. ?-ODAP was increased with increasing mannitol concentration till -0.23MPa while at this osmotic potential created with PEG-20,000 the formation of ?-ODAP is completely inhibited in low toxin calli. These experiments demonstrate the importance of environmental factors, especially micronutrients and salinity, on the biosynthesis of ?-ODAP. PMID:20654675

Haque, Rabiul M; Kuo, Yu-Haey; Lambein, Fernand; Hussain, Muhammed

2010-07-21

309

Effect of environmental factors on the biosynthesis of the neuro-excitatory amino acid ?-ODAP (?-N-oxalyl-L-?,?-diaminopropionic acid) in callus tissue of Lathyrus sativus.  

UK PubMed Central (United Kingdom)

Habituated callus tissues derived from leaf explants of Lathyrus sativus L. (grass pea) were cultured under different environmental conditions such as drought, salinity and deficiency or oversupply of micronutrients. The biosynthesis of the neuro-excitatory ?-ODAP (?-N-oxalyl-L-?,?-diaminopropionic acid) was induced by feeding the precursor BIA, (?-isoxazolin-5-on-2-yl)-alanine, to those calli habituated under different stress conditions. Conversion of BIA into ?-ODAP was reduced by Zn(2+) at different levels of Fe(2+) supplements while excess of Fe(2+) enhanced it at different Zn(2+) levels in the media. The biosynthesis of ?-ODAP was increased by both oversupply and deficiency of Mn(2+) manganese while B(3+) as well as Co(2+) increased it significantly by oversupply. Al(3+) enhanced the conversion of BIA into ?-ODAP significantly in a concentration-dependent way. Cu(2+) also reduced the formation of ?-ODAP when increased in the media. Mo(6+) had no apparent effect. NaCl decreased the conversion of BIA into ?-ODAP proportionately with the increase in salinity. ?-ODAP was increased with increasing mannitol concentration till -0.23MPa while at this osmotic potential created with PEG-20,000 the formation of ?-ODAP is completely inhibited in low toxin calli. These experiments demonstrate the importance of environmental factors, especially micronutrients and salinity, on the biosynthesis of ?-ODAP.

Haque RM; Kuo YH; Lambein F; Hussain M

2011-03-01

310

Percent body fat estimations in college women using field and laboratory methods: a three-compartment model approach  

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Full Text Available Abstract Background Methods used to estimate percent body fat can be classified as a laboratory or field technique. However, the validity of these methods compared to multiple-compartment models has not been fully established. This investigation sought to determine the validity of field and laboratory methods for estimating percent fat (%fat) in healthy college-age women compared to the Siri three-compartment model (3C). Methods Thirty Caucasian women (21.1 ± 1.5 yrs; 164.8 ± 4.7 cm; 61.2 ± 6.8 kg) had their %fat estimated by BIA using the BodyGram™ computer program (BIA-AK) and population-specific equation (BIA-Lohman), NIR (Futrex® 6100/XL), a quadratic (SF3JPW) and linear (SF3WB) skinfold equation, air-displacement plethysmography (BP), and hydrostatic weighing (HW). Results All methods produced acceptable total error (TE) values compared to the 3C model. Both laboratory methods produced similar TE values (HW, TE = 2.4%fat; BP, TE = 2.3%fat) when compared to the 3C model, though a significant constant error (CE) was detected for HW (1.5%fat, p ? 0.006). The field methods produced acceptable TE values ranging from 1.8 – 3.8 %fat. BIA-AK (TE = 1.8%fat) yielded the lowest TE among the field methods, while BIA-Lohman (TE = 2.1%fat) and NIR (TE = 2.7%fat) produced lower TE values than both skinfold equations (TE > 2.7%fat) compared to the 3C model. Additionally, the SF3JPW %fat estimation equation resulted in a significant CE (2.6%fat, p ? 0.007). Conclusion Data suggest that the BP and HW are valid laboratory methods when compared to the 3C model to estimate %fat in college-age Caucasian women. When the use of a laboratory method is not feasible, NIR, BIA-AK, BIA-Lohman, SF3JPW, and SF3WB are acceptable field methods to estimate %fat in this population.

Moon Jordan R; Hull Holly R; Tobkin Sarah E; Teramoto Masaru; Karabulut Murat; Roberts Michael D; Ryan Eric D; Kim So; Dalbo Vincent J; Walter Ashley A; Smith Abbie T; Cramer Joel T; Stout Jeffrey R

2007-01-01

311

Gasto energético de adultos brasileños saludables: una comparación de métodos Energy expenditure of healthy brazilian adults: a comparison of methods  

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Full Text Available Hay diversos métodos disponibles para medir el consumo de energía en el ser humano. Debido al alto costo y pequeño número de laboratorios capaces de utilizar la calorimetría directa y la técnica del agua doblemente marcada, se ha realizado un número relativamente pequeño de mediciones del gasto energético utilizándose estos métodos. Así, cada día más, los investigadores se atienen en alto grado a los métodos de calorimetría indirecta (CI) y bioimpedancia eléctrica (BIA) y los clínicos a las ecuaciones de predicción para calcular los requerimientos de energía total en sus estudios y pacientes respectivamente. Objetivo: Evaluar el Gasto Energético Basal (GEB) y el Gasto Energético Total (GET) de individuos saludables comparando los resultados de CI, BIA y ecuaciones predictivas con los de requerimiento estimado de energía (EER), Fleisch, FAO/WHO/UNU 1985 y 2001. Material y métodos: Se evaluó el gasto energético en 81 individuos de ambos sexos por CI y BIA. De estos, fueron calculados el GEB por las ecuaciones FAO/WHO/UNU 1985 y 2001 y el GET por EER, Fleisch y FAO/WHO/UNU 1985 y 2001. Los datos se analizaron con el programa Sigma Stat for Windows versión 2.03 y se utilizó eltest de Dunn's para la comparación de las medianas obtenidas por los métodos y ecuaciones (p There are many available methods to measure the human energy consumption. Due to the high cost and small number of laboratories able to perform it, the direct calorimetry and doubly labeled water technique are rarely used to measure the energy expenditure. As consequence, there is an increase use of the indirect calorimetry and bioelectrical impedance analysis methods by researchers and predictive equations by physicians to calculate the total energy requirements in research and in clinic. Objective: To evaluate the basal energy expenditure (GEB) and total energy expenditure (GET) of healthy subjects comparing results of indirect calorimetry (CI), bioelectrical impedance analysis (BIA) and predictive equations such as estimated energy requirements (EER), Fleish, FAO/WHO/UNU 1985 and 2001. Material and methods: It was evaluated the energy expenditure in 81 subjects of both gender by CI and BIA. Of these, the GEB by predictive equations FAO/WHO/UNU 1985 and 2001 and the GET by EER, Fleisch and FAO/WHO/UNU 1985 and 2001 were calculated. The data was analyzed with the software Sigma Stat for Windows version 2.03 and Dunn's test was used for comparison of mean obtained with methods and equations (p < 0.05). Results: It was verified that 60.5% of the participants were men. The majority of subjects were eutrofic. BIA showed significant differences between men and women. The differences between the values of GEB, obtained by BIA and CI, were statistically significant only for women (p < 0.05) with an underestimation of the GEB results obtained by BIA in relation to those obtained by CI. Significant difference was found between the predictive equations and CI for both sexes, also demonstrating an underestimation of the equations in relation to CI. It was observed an overestimation of GET with the predictive equations of FAO/WHO/UNU/85 and 2001 in relation to EER and Fleisch for both sexes. Conclusion: The estimation of GEB can be carried out by both BIA and CI, although BIA must be used with criteria since it underestimates in a significant way for women. In relation to the predictive equations, overestimation can develop positive energy balance in populations with risks for overweight and obesity. Thus, it is necessary comparisons to identify the limitations of each method.

F. C. Esteves de Oliveira; A. C. de Mello Cruz; C. Gonçalves Oliveira; A. C. Rodrigues Ferreira Cruz; V. Mayumi Nakajima; J. Bressan

2008-01-01

312

Three efflux pumps are required to provide efficient tolerance to toluene in Pseudomonas putida DOT-T1E.  

Science.gov (United States)

In Pseudomonas putida DOT-T1E multidrug efflux pumps of the resistance-nodulation-division family make a major contribution to solvent resistance. Two pumps have been identified: TtgABC, expressed constitutively, and TtgDEF, induced by aromatic hydrocarbons. A double mutant lacking both efflux pumps was able to survive a sudden toluene shock if and only if preinduced with small amounts of toluene supplied via the gas phase. In this article we report the identification and characterization in this strain of a third efflux pump, named TtgGHI. The ttgGHI genes form an operon that is expressed constitutively at high levels from a single promoter. In the presence of toluene the operon is expressed at an even higher level from two promoters, the constitutive one and a previously unreported one that is inducible and that partially overlaps the constitutive promoter. By site-directed mutagenesis we constructed a single ttgH mutant which was shown to be unable to survive sudden 0.3% (vol/vol) toluene shocks regardless of the preculture conditions. The mutation was transferred to single and double mutants to construct mutant strains in which two or all three pumps are knocked out. Survival analysis of induced and noninduced cells revealed that the TtgABC and TtgGHI pumps extruded toluene, styrene, m-xylene, ethylbenzene, and propylbenzene, whereas the TtgDEF pump removed only toluene and styrene. The triple mutant was hypersensitive to toluene, as shown by its inability to grow with toluene supplied via the vapor phase. PMID:11395460

Rojas, A; Duque, E; Mosqueda, G; Golden, G; Hurtado, A; Ramos, J L; Segura, A

2001-07-01

313

Analysis and Prediction of Energy Production in Concentrating Photovoltaic (CPV) Installations  

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Full Text Available A method for the prediction of Energy Production (EP) in Concentrating Photovoltaic (CPV) installations is examined in this study. It presents a new method that predicts EP by using Global Horizontal Irradiation (GHI) and the Photovoltaic Geographical Information System (PVGIS) database, instead of Direct Normal Irradiation (DNI) data, which are rarely recorded at most locations. EP at four Spanish CPV installations is analyzed: two are based on silicon solar cells and the other two on multi-junction III-V solar cells. The real EP is compared with the predicted EP. Two methods for EP prediction are presented. In the first preliminary method, a monthly Performance Ratio (PR) is used as an arbitrary constant value (75%) and an estimation of the DNI. The DNI estimation is obtained from GHI measurements and the PVGIS database. In the second method, a lineal model is proposed for the first time in this paper to obtain the predicted EP from the estimated DNI. This lineal model is the regression line that correlates the real monthly EP and the estimated DNI in 2009. This new method implies that the monthly PR is variable. Using the new method, the difference between the predicted and the real EP values is less than 2% for the annual EP and is in the range of 5.6%–16.1% for the monthly EP. The method that uses the variable monthly PR allows the prediction of the EP with reasonable accuracy. It is therefore possible to predict the CPV EP for any location, using only widely available GHI data and the PVGIS database.

Francisco J. Gómez-Gil; Xiaoting Wang; Allen Barnett

2012-01-01

314

Hydration in advanced cancer: can bioelectrical impedance analysis improve the evidence base? A systematic review of the literature.  

UK PubMed Central (United Kingdom)

CONTEXT: Decisions surrounding the administration of clinically assisted hydration to patients dying of cancer can be challenging because of the limited understanding of hydration in advanced cancer and a lack of evidence to guide health care professionals. Bioelectrical impedance analysis (BIA) has been used to assess hydration in various patient groupings, but evidence for its use in advanced cancer is limited. OBJECTIVES: To critically appraise existing methods of hydration status assessment in advanced cancer and review the potential for BIA to assess hydration in advanced cancer. METHODS: Searches were carried out in four electronic databases. A hand search of selected peer-reviewed journals and conference abstracts also was conducted. Studies reporting (de)hydration assessment (physical examination, biochemical measures, symptom assessment, and BIA) in patients with advanced cancer were included. RESULTS: The results highlight how clinical examination and biochemical tests are standard methods of assessing hydration, but limitations exist with these methods in advanced cancer. Furthermore, there is disagreement over the evidence for some commonly associated symptoms with dehydration in cancer. Although there are limitations with using BIA alone to assess hydration in advanced cancer, analysis of BIA raw measurements through the method of bioelectrical impedance vector analysis may have a role in this population. CONCLUSION: The benefits and burdens of providing clinically assisted hydration to patients dying of cancer are unclear. Bioelectrical impedance vector analysis shows promise as a hydration assessment tool but requires further study in advanced cancer. Innovative methodologies for research are required to add to the evidence base and ultimately improve the care for the dying.

Nwosu AC; Mayland CR; Mason SR; Khodabukus AF; Varro A; Ellershaw JE

2013-09-01

315

Prediction of fat-free mass using bioelectrical impedance analysis in young adults from five populations of African origin.  

UK PubMed Central (United Kingdom)

Background/objectives:Bioelectrical impedance analysis (BIA) is used in population and clinical studies as a technique for estimating body composition. Because of significant under-representation in existing literature, we sought to develop and validate predictive equation(s) for BIA for studies in populations of African origin.Subjects/methods:Among five cohorts of the Modeling the Epidemiologic Transition Study, height, weight, waist circumference and body composition, using isotope dilution, were measured in 362 adults, ages 25-45 with mean body mass indexes ranging from 24 to 32. BIA measures of resistance and reactance were measured using tetrapolar placement of electrodes and the same model of analyzer across sites (BIA 101Q, RJL Systems). Multiple linear regression analysis was used to develop equations for predicting fat-free mass (FFM), as measured by isotope dilution; covariates included sex, age, waist, reactance and height(2)/resistance, along with dummy variables for each site. Developed equations were then tested in a validation sample; FFM predicted by previously published equations were tested in the total sample.Results:A site-combined equation and site-specific equations were developed. The mean differences between FFM (reference) and FFM predicted by the study-derived equations were between 0.4 and 0.6?kg (that is, 1% difference between the actual and predicted FFM), and the measured and predicted values were highly correlated. The site-combined equation performed slightly better than the site-specific equations and the previously published equations.Conclusions:Relatively small differences exist between BIA equations to estimate FFM, whether study-derived or published equations, although the site-combined equation performed slightly better than others. The study-derived equations provide an important tool for research in these understudied populations.

Luke A; Bovet P; Forrester TE; Lambert EV; Plange-Rhule J; Dugas LR; Durazo-Arvizu RA; Kroff J; Richie WN; Schoeller DA

2013-09-01

316

Performance of bioelectrical impedance analysis in the diagnosis of metabolic syndrome.  

UK PubMed Central (United Kingdom)

OBJECTIVE: Central obesity is a prerequisite for the diagnosis of metabolic syndrome (MetS). Precise measurement of visceral fat by bioelectrical impedance analysis (BIA) has been validated. The aim of this study was to investigate the diagnostic performance of BIA in MetS and validate the best cutoff in a large adult cohort. MATERIALS AND METHODS: The study was performed on the MELEN Study cohort-a prospectively designed survey on the prevalence of cardiometabolic risk factors in Turkish adults. The final cohort consisted of 2219 participants. Weight and visceral body composition were measured without shoes in light indoor clothes using a bioimpedance analyzer (Omron BF 510; Omron Corp, Kyoto, Japan). Plasma concentrations of cholesterol, insulin, fasting triglycerides, high-density lipoprotein cholesterol, glucose, and other biochemical variables were measured. The diagnostic performance of visceral fat measurement by BIA in patients with MetS was assessed. RESULTS: Metabolic syndrome was detected in 751 participants (520 women and 231 men with a mean age of 55 [12] years; 34% of the whole study population). Total body fat and visceral fat levels were higher in subjects with MetS. Correlation analyses showed that there were significant correlations between anthropometric and BIA measurements. Receiver operating curve characteristics of visceral adiposity revealed the best cutoff values as greater than 12% for men and greater than 9% for women. The diagnostic performance was good in both sexes (the sensitivity/specificity and area-under-the-curve values were 76%/75% and 0.83 for men and 83%/67% and 0.81 for women, respectively). CONCLUSIONS: Visceral fat measured with BIA is an easily applicable and useful method for identifying people with MetS. The best cutoff values were higher than 12% for men and higher than 9% for women.

Ozhan H; Alemdar R; Caglar O; Ordu S; Kaya A; Albayrak S; Turker Y; Bulur S

2012-03-01

317

Biosynthesis of benzylisoquinoline alkaloids in Corydalis bracteata: compartmentation and seasonal dynamics.  

Science.gov (United States)

Numerous species of the genus Corydalis (Papaveraceae) produce a large spectrum of benzylisoquinoline alkaloids (BIA), some of which are of potential therapeutic value, but no information on sites of their biosynthesis and compartmentation is available. This study focuses on the biosynthesis, compartmentation and seasonal dynamics of BIA in Corydalis bracteata (Steph. ex Willd) Pers., a geophyte with a very short spring vegetation period, which for the rest of the year is represented by underground tubers with buds. It was found that all organs of C. bracteata contained high levels of BIA, the highest concentrations being detected in underground tuber buds in early autumn. Neither xylem nor phloem sap contained alkaloids throughout the year but BIA were present in the apoplastic wash fluid of the tuber. The absence of long-distance transport of alkaloids was confirmed by the experiment using an isotopically labeled tracer, [ring-(13)C6]-tyramine: when whole plants were fed with the tracer with via the roots, the alkaloids became labeled in the roots only and not in other organs. However, when detached roots, leaves, tubers and stems were exposed to [ring-(13)C6]-tyramine, the label was incorporated into alkaloids in all organs. We conclude that no long-distance translocation of alkaloids occurs between organs of C. bracteata, while in the tuber the cell-to-cell transport of alkaloids could occur via the apoplast. In contrast to other BIA-producing species, every organ of C. bracteata was found to be capable of de novo biosynthesis of the full complement of alkaloids. PMID:23664175

Khodorova, Nadezda V; Shavarda, Alexey L; Lequart-Pillon, Michelle; Laberche, Jean-Claude; Voitsekhovskaja, Olga V; Boitel-Conti, Michèle

2013-05-07

318

Biosynthesis of benzylisoquinoline alkaloids in Corydalis bracteata: compartmentation and seasonal dynamics.  

UK PubMed Central (United Kingdom)

Numerous species of the genus Corydalis (Papaveraceae) produce a large spectrum of benzylisoquinoline alkaloids (BIA), some of which are of potential therapeutic value, but no information on sites of their biosynthesis and compartmentation is available. This study focuses on the biosynthesis, compartmentation and seasonal dynamics of BIA in Corydalis bracteata (Steph. ex Willd) Pers., a geophyte with a very short spring vegetation period, which for the rest of the year is represented by underground tubers with buds. It was found that all organs of C. bracteata contained high levels of BIA, the highest concentrations being detected in underground tuber buds in early autumn. Neither xylem nor phloem sap contained alkaloids throughout the year but BIA were present in the apoplastic wash fluid of the tuber. The absence of long-distance transport of alkaloids was confirmed by the experiment using an isotopically labeled tracer, [ring-(13)C6]-tyramine: when whole plants were fed with the tracer with via the roots, the alkaloids became labeled in the roots only and not in other organs. However, when detached roots, leaves, tubers and stems were exposed to [ring-(13)C6]-tyramine, the label was incorporated into alkaloids in all organs. We conclude that no long-distance translocation of alkaloids occurs between organs of C. bracteata, while in the tuber the cell-to-cell transport of alkaloids could occur via the apoplast. In contrast to other BIA-producing species, every organ of C. bracteata was found to be capable of de novo biosynthesis of the full complement of alkaloids.

Khodorova NV; Shavarda AL; Lequart-Pillon M; Laberche JC; Voitsekhovskaja OV; Boitel-Conti M

2013-08-01

319

Rheumatoid cachexia, central obesity and malnutrition in patients with low-active rheumatoid arthritis: feasibility of anthropometry, Mini Nutritional Assessment and body composition techniques.  

UK PubMed Central (United Kingdom)

BACKGROUND AND AIMS: The concurrent decrease in fat free mass (FFM) and increase in fat mass (FM), including central obesity, in patients with rheumatoid arthritis (RA) may be related to increased cardiovascular morbidity as well as to functional decline. The objectives of this study were to evaluate body composition and nutritional status in patients with RA and the feasibility of bioelectrical impedance (BIA) to detect rheumatoid cachexia. METHODS: Eighty RA outpatients (76% women), mean age 61 (range 22-80) years and with mean disease duration of 6 (range 1-52) years, were assessed by body mass index (BMI), waist circumference (WC), whole-body dual-energy X-ray absorptiometry (DXA), BIA and the Mini Nutritional Assessment (MNA). RESULTS: Fat free mass index (FFMI; kg/m(2)) was low in 26% of the women and in 21% of the men. About every fifth patient displayed concomitant low FFMI and elevated fat mass index (FMI; kg/m(2)), i.e. rheumatoid cachexia. BMI and MNA were not able to detect this condition. Sixty-seven percent had increased WC. Reduced FFM was independently related to age (p = 0.022), disease duration (p = 0.027), ESR (p = 0.011) and function trendwise (p = 0.058). There was a good relative agreement between DXA and BIA (FM r (2) = 0.94, FFM r (2) = 0.92; both p < 0.001), but the limits of agreement were wide for each variable, i.e. for FM -3.3 to 7.8 kg; and for FFM -7.9 to 3.7 kg. CONCLUSION: Rheumatoid cachexia and central obesity were common in patients with RA. Neither BMI nor MNA could detect this properly. There was a good relative agreement between DXA and BIA, but the limits of agreement were wide, which may restrict the utility of BIA in clinical practice.

Elkan AC; Engvall IL; Cederholm T; Hafström I

2009-08-01

320

Wrodzone miopatie – choroby mi??ni szkieletowych zwi?zane z zaburzeniami struktury i funkcji filamentu aktynowego  

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Full Text Available Wrodzone miopatie s? heterogenn? pod wzgl?dem klinicznym i genetycznym grup? chorób uk?adu mi??niowego, charakteryzuj?c? si? strukturalnymi zaburzeniami w obr?bie w?ókien mi??niowych oraz os?abieniem i deformacj? ró?nych partii mi??ni. W obrazie klinicznym pacjenci prezentuj? wiele objawów – od ostrych, prowadz?cych do ?mierci we wczesnym okresie noworodkowym, do ?agodnych ujawniaj?cych si? dopiero w wieku dojrza?ym. W obrazach mikroskopowych mi??ni zmiany strukturalne przybieraj? posta? nitkowatych wtr?tów w sarkoplazmie (miopatia nemalinowa – NM) lub j?drze komórkowym (miopatia z wewn?trzj?drowymi pa?eczkami – IRM), czapeczkowatych struktur umieszczonych obwodowo w komórce (miopatia typu czapeczek – CD), akumulacji filamentów aktynowych we w?óknie mi??niowym (miopatia aktynowa – AM), zmian w wielko?ci i liczbie wolnych i szybkich w?ókien mi??niowych (wrodzona dysproporcja typów w?ókien – CFTD), nieregularnej linii Z, czy te? zmian w po?o?eniu j?der komórkowych. Za rozwój wrodzonych miopatii odpowiedzialne s? mutacje w kilku genach koduj?cych bia?ka mi??niowe. Najcz?stsze mutacje dotycz? genów koduj?cych bia?ka zwi?zane z cienkim filamentem – aktyn? ([i]ACTA1[/i]), tropomiozyn? ([i]TPM2 i TPM3[/i]), troponin? ([i]TNNT1[/i]) i [i]neb[/i]ulin? (NEB). Badania[i] in vitro [/i]i [i]in vivo [/i]wykaza?y, ?e zidentyfikowane mutacje wywo?uj? zmiany w strukturze bia?ek cienkiego filamentu, zaburzaj?ce procesy polimeryzacji i stabilizacji aktyny, jej wewn?trzkomórkowej lokalizacji oraz regulacji oddzia?ywa? aktyny z miozyn?. Wiele wyników wskazuje na „toksyczne” dzia?anie bia?ka zmienionego przez mutacj?. Niestety, nie istnieje prosta korelacja mi?dzy zmian? w funkcji bia?ek a patomorfologi? i objawami klinicznymi miopatii.

Katarzyna Robaszkiewicz; Joanna Moraczewska

2011-01-01

 
 
 
 
321

Accuracy of direct segmental multi-frequency bioimpedance analysis in the assessment of total body and segmental body composition in middle-aged adult population.  

UK PubMed Central (United Kingdom)

BACKGROUND & AIMS: Body composition measurement is a valuable tool for assessing nutritional status and physical fitness in a variety of clinical settings. Although bioimpedance analysis (BIA) can easily assess body composition, its accuracy remains unclear. We examined the accuracy of direct segmental multi-frequency BIA technique (DSM-BIA) in assessing different body composition parameters, using dual energy X-ray absorptiometry (DEXA) as a reference standard. METHODS: A total of 484 middle-aged participants from the Leiden Longevity Study were recruited. Agreements between DSM-BIA and DEXA for total and segmental body composition quantification were assessed using intraclass correlation coefficients and Bland-Altman plots. RESULTS: Excellent agreements were observed between both techniques in whole body lean mass (ICC female = 0.95, ICC men = 0.96), fat mass (ICC female = 0.97, ICC male = 0.93) and percentage body fat (ICC female = 0.93, ICC male = 0.88) measurements. Similarly, Bland-Altman plots revealed narrow limits of agreements with small biases noted for the whole body lean mass quantification but relatively wider limits for fat mass and percentage body fat quantifications. In segmental lean muscle mass quantification, excellent agreements between methods were demonstrated for the upper limbs (ICC female?0.91, ICC men?0.87) and lower limbs (ICC female?0.83, ICC male?0.85), with good agreements shown for the trunk measurements (ICC female = 0.73, ICC male = 0.70). CONCLUSIONS: DSM-BIA is a valid tool for the assessments of total body and segmental body composition in the general middle-aged population, particularly for the quantification of body lean mass.

Ling CH; de Craen AJ; Slagboom PE; Gunn DA; Stokkel MP; Westendorp RG; Maier AB

2011-10-01

322

Measures of body fat in South Asian adults.  

Science.gov (United States)

Background:South Asian people who originate from the Indian subcontinent have greater percent body fat (%BF) for the same body mass index (BMI) compared with white Caucasians. This has been implicated in their increased risk of type 2 diabetes and cardiovascular disease. There is limited information comparing different measures of body fat in this ethnic group.Objectives:The objectives of this study were: (1) to investigate the correlation of %BF measured by a foot-to-foot bioelectrical impedance analysis (FF-BIA) against the BOD POD, a method of air-displacement plethysmography, and (2) to determine the correlations of simple anthropometric measures, (that is, BMI, body adiposity index (BAI), waist circumference (WC), hip circumference (HC) and waist-to-hip ratio (WHR)) against the BOD POD measure of body fat.Methods:Eighty apparently healthy South Asian men and women were recruited from the community, and measurements of height, weight, WC, HC and body composition using Tanita FF-BIA and BOD POD were taken.Results:The mean±s.d. age of participants was 27.78±10.49 years, 42.5% were women, and the mean BMI was 22.68±3.51?kg?m(-2). The mean body fat (%BF) calculated by FF-BIA and BOD POD was 21.94±7.88% and 26.20±8.47%, respectively. The %BF calculated by FF-BIA was highly correlated with the BOD POD (Pearson's r=0.83, P21?kg?m(-2) than those with a BMI ?21?kg?m(-2).Conclusion:The FF-BIA and BAI estimates of %BF are highly correlated with that of BOD POD among people of South Asian origin, although both methods somewhat underestimate % BF. Furthermore, their correlations with % BF from BOD POD are significantly weakened among men and women with a BMI ?21?kg?m(-2). PMID:23712281

Kalra, S; Mercuri, M; Anand, S S

2013-05-27

323

Low graft function and ongoing hyperparathyroidism are closely related to post-transplantation osteoporosis.  

UK PubMed Central (United Kingdom)

INTRODUCTION: Renal transplantation (RT) is the gold standard therapy for chronic renal failure. Immunosuppressive drug choice, malnutrition, adynamic bone disease and hyperparathyroidism are important factors impacting the development of posttransplant osteoporosis. Body composition analysis with bioimpedance devices (BIA) is a useful noninvasive tool to detect malnutrition among the RT population. We investigated the effects of graft function, immunosuppressive drug regimens and biochemical characteristics on bone mineral density of RT patients as well as the reliability of BIA measurements to diagnose osteoporosis. METHODS: One hundred three recipients with a minimum of 12 months post-RT follow-up underwent body composition analysis using the Tanita Analyzer. The last 6 months of monthly biochemical parameters and glomerular filtration rates (GFR) as well as drug regimens were collected retrospectively from patient charts. Patients were divided into 2 groups, according to their femoral neck and lumbal T scores, as osteoporosis (n = 42) and control groups (n = 61). RESULTS: The mean GFR of osteoporotic patients was significantly lower (P = .04) and parathyroid hormone (PTH) levels significantly higher (P = .002). According to BIA, osteoporotic patients showed lower bone mass, fat mass, visceral fat ratio, muscle mass, waist-hip ratios, and body mass index values (P < .05). Correlation analysis revealed GFR to negatively correlate with PTH (r = -0.231, P = .010) and positively with femur t scores (r = 0.389, P = .0001) as well as with BIA findings (P = .0001). In contrast, PTH levels in negatively correlated with lumbar and femoral neck t scores (r = -0.22, -0.4 and P = .026, .0001, respectively) but not with BIA findings including bone mass. CONCLUSION: Changes in bone density after RT were affected by graft function. The rapid loss of bone mineral density emphasizes the need for prevention started in the early posttransplant period. BMD measurements provided a guide for treatment and for subsequent evaluation.

Tutal E; Uyar ME; Colak T; Bal Z; Demirci BG; Bozkurt T; Sezer S; Acar FN

2013-05-01

324

The diagnostic accuracy of multi-frequency bioelectrical impedance analysis in diagnosing dehydration after stroke.  

UK PubMed Central (United Kingdom)

BACKGROUND: Non-invasive methods for detecting water-loss dehydration following acute stroke would be clinically useful. We evaluated the diagnostic accuracy of multi-frequency bioelectrical impedance analysis (MF-BIA) against reference standards serum osmolality and osmolarity. MATERIAL AND METHODS: Patients admitted to an acute stroke unit were recruited. Blood samples for electrolytes and osmolality were taken within 20 minutes of MF-BIA. Total body water (TBW%), intracellular (ICW%) and extracellular water (ECW%), as percentages of total body weight, were calculated by MF-BIA equipment and from impedance measures using published equations for older people. These were compared to hydration status (based on serum osmolality and calculated osmolarity). The most promising Receiver Operating Characteristics curves were plotted. RESULTS: 27 stroke patients were recruited (mean age 71.3, SD10.7). Only a TBW% cut-off at 46% was consistent with current dehydration (serum osmolality >300 mOsm/kg) and TBW% at 47% impending dehydration (calculated osmolarity ?295-300 mOsm/L) with sensitivity and specificity both >60%. Even here diagnostic accuracy of MF-BIA was poor, a third of those with dehydration were wrongly classified as hydrated and a third classified as dehydrated were well hydrated. Secondary analyses assessing diagnostic accuracy of TBW% for men and women separately, and using TBW as a percentage of lean body mass showed some promise, but did not provide diagnostically accurate measures across the population. CONCLUSIONS: MF-BIA appears ineffective at diagnosing water-loss dehydration after stroke and cannot be recommended as a test for dehydration, but separating assessment by sex, and using TBW as a percentage of lean body weight may warrant further investigation.

Kafri MW; Myint PK; Doherty D; Wilson AH; Potter JF; Hooper L

2013-01-01

325

Comparison of two analytical platforms for the clinical qualification of Alzheimer's disease biomarkers in pathologically-confirmed dementia.  

UK PubMed Central (United Kingdom)

Combined analysis of the Alzheimer's disease (AD) biomarkers amyloid-?(1-42) (A?(1-42)), total tau (T-tau), and hyperphosphorylated tau (P-tau(181P)) in cerebrospinal fluid (CSF) reduces the uncertainty associated with clinical dementia diagnosis. The present study evaluated the diagnostic accuracy of the CSF biomarker concentrations obtained with a multi-analyte Luminex assay (INNO-BIA AlzBio3) in comparison to single-analyte ELISA tests (INNOTEST). Data from 66 pathologically-confirmed dementia patients (51 AD and 15 non-AD) and 95 controls were included. Cut-off values were determined for each individual biomarker determined using both methods for different diagnostic challenges (dementia-controls; AD-controls; AD-non-AD). Comparing the diagnostic accuracy of individual cut-off values between INNO-BIA and INNOTEST, no relevant differences could be identified. Logistic regression was used in addition to identify the best combination of predictor variables (biomarkers). Discrimination of dementia patients from controls using A?(1-42) and T-tau yielded a diagnostic accuracy of 0.87 and 0.90 for INNO-BIA and INNOTEST, respectively. Discriminating AD patients from controls, the diagnostic accuracy was 0.90 and 0.93 for INNO-BIA and INNOTEST, respectively. Optimal discrimination of AD and non-AD patients was achieved by combining A?(1-42) and P-tau(181P) (diagnostic accuracy = 0.86). In conclusion, which AD biomarkers or combination thereof are most informative is dependent on the differential diagnosis, but the clinical value of these markers in each of the differential diagnoses is independent of the method by which concentrations are determined. Since the clinical value of the ELISA (INNOTEST) and Luminex (INNO-BIA) tests is comparable, further research to select the most suitable analytical platform for routine CSF biomarker measurements is needed.

Le Bastard N; Coart E; Vanderstichele H; Vanmechelen E; Martin JJ; Engelborghs S

2013-01-01

326

Bioimpedance prediction of fat-free mass from dual-energy X-ray absorptiometry in a multi-ethnic group of 2-year-old children.  

UK PubMed Central (United Kingdom)

BACKGROUND/OBJECTIVES: Bioimpedance analysis (BIA) is a simple, convenient and widely used tool for the measurement of body composition in population surveys and surveillance. Prediction equations based on BIA applicable to preschool children are available but are based on total body water estimation and have not been developed across multiple ethnic groups. Our aim was to develop a BIA-based equation in a multi-ethnic sample of 2-year old using fat-free mass (FFM) from dual-energy X-ray absorptiometry (DXA) as criterion measure. SUBJECTS/METHODS: Single-frequency hand-to-foot BIA (model BIM4, Impedimed) and whole-body DXA measurements were carried out in 77 (35 boys, 42 girls; 27 European, 20 Polynesian, 30 Asian and other) healthy preschool children (age range 22-38 months). Body mass index s.d. scores were 0.41 ± 1.23 for boys and 0.61 ± 1.09 for girls. The performance of published equations applicable to this age group was assessed. The predicted residual sum of squares method was used to develop and cross-validate a multiple regression equation relating FFM to BIA measures. RESULTS: Published equations performed poorly for estimating FFM in this group of children. The prediction equation developed in all 77 children was: FFM (kg)=0.367 height(cm)(2)/resistance+0.188 weight (kg)+0.077 height (cm)+0.273 sex (male=1, female=0)-2.490, R(2)=0.89, standard error of estimate=0.50?kg. Ethnicity and age did not add significantly to the model. CONCLUSIONS: We have developed an equation that may have application for prediction of FFM in 2-3-year-old children, which does not require determination of hydration factors. Further work should be carried out using DXA scanning to extend the applicable age range.

Rush EC; Bristow S; Plank LD; Rowan J

2013-02-01

327

Study and classification of the abdominal adiposity throughout the application of the two-dimensional predictive equation Garaulet et al., in the clinical practice Estudio y clasificación de la adiposidad abdominal mediante la aplicación de la ecuación predictiva bidimensional de Garaulet et al., en la práctica clínica  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction: The excess of visceral abdominal adipose tissue is one of the major concerns in obesity and its clinical treatment. Objective: To apply the two-dimensional predictive equation proposed by Garaulet et al. to determine the abdominal fat distribution and to compare the results with the body composition obtained by multi-frequency bioelectrical impedance analysis (M-BIA). Subjects/methods: We studied 230 women, who underwent anthropometry and M-BIA. The predictive equation was applied. Multivariate lineal and partial correlation analyses were performed with control for BMI and % body fat, using SPSS 15.0 with statistical significance P Introducción: El exceso de tejido adiposo abdominal visceral es una de las mayores preocupaciones en la obesidad y su tratamiento clínico. Objetivo: Aplicar la ecuación predictiva bidimensional propuesta por Garaulet et al., para determinar la distribución de la grasa abdominal y comparar los resultados con la composición corporal obtenida mediante el análisis de impedancia bioeléctrica multi-frecuencia (M-BIA). Sujetos/métodos: Estudiamos a 230 mujeres a las que se sometió a antropometría y M-BIA. Se aplicó la ecuación predicitiva. Se realizaron correlaciones lineales multivariadas y parciales controlando el IMC y el % de grasa corporal, utilizando SPSS 15.0 con significación estadística P < 0,05. Resultados: En global, se consideró que las mujeres tenían una distribución subcutánea de la grasa abdominal. La grasa troncal, regional y la masa muscular se asociaron negativamente con VA/SApredicted, mientras que le índice visceral obtenido mediante M-BIA se correlacionó positivamente con VA/SApredicted. Discusión/conclusión: La ecuación predictiva puede ser útil en la práctica clínica para obtener una clasificación segura, barata y precisa de la obesidad abdominal.

C. M.ª Piernas Sánchez; E. M.ª Morales Falo; S. Zamora Navarro; M. Garaulet Aza

2010-01-01

328

Change in fat-free mass assessed by bioelectrical impedance, total body potassium and dual energy X-ray absorptiometry during prolonged weight loss.  

DEFF Research Database (Denmark)

A total of 16 obese women (body mass index (BMI) 30-43 kg m(-2)) participated in a weight reduction study. Before and after a weight loss of 11.7 +/- 7.4 kg (mean +/- SD), body composition was assessed by dual energy X-ray absorptiometry (DXA), and total body potassium counting (TBK). These measurements were compared with bioimpedance analysis (BIA) by applying 11 predictive BIA equations published in the literature. Predictive equations for the present study population were developed, with the use of fat-free mass (FFM) as assessed by TBK and DXA as references in multiple regression analysis. The results of the BIA equations varied widely; FFM was generally overestimated by BIA as compared with DXA and TBK before and after weight loss. During weight loss, the FFM did not change, as estimated by DXA (1.3 +/- 2.3 kg, p > 0.05) and TBK (0.9 +/- 2.9 kg, p > 0.05). The recorded change in impedance (R) was also insignificant. Three BIA equations from the literature, which were not specific for the degree of obesity in the present study group, predicted changes in FFM (from 0.5 + 3.6 to 2.4 +/- 4.4kg, p > 0.05) that were comparable with those estimated by the reference methods. Eight equations from the literature, which included equations specific for the degree of obesity in the study group, and the group specific equations developed for the present population predicted significant changes in FFM during weight loss (from 2.3 +/- 3.0 to 5.0 +/- 3.0 kg, p < 0.05). We conclude that in obesity most predictive equations are unable to predict static body composition and are not reproducible for individuals over time. However, a significant or insignificant change in R (without accompanying predictive equations) may be used to indicate whether FFM is lost or preserved in groups of obese subjects.

Hendel, H W; Gotfredsen, A

1996-01-01

329

Composição corporal em mulheres com deficiência da 21-hidroxilase: comparação dos métodos antropométricos e de impedância bioelétrica em relação a um grupo controle/ Body composition in females with 21-hydroxylase deficiency: comparison of anthropometric methods and bioelectric impedance in relation to a control group  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese OBJETIVO: Estimar a composição corporal avaliada pela espessura de dobras cutâneas (EDC) e pela impedância bioelétrica (BIA) em um grupo de mulheres com hiperplasia adrenal congênita, forma clássica por deficiência da enzima 21-hidroxilase (HAC-C-D21OH) e em relação ao um grupo controle. PACIENTES E MÉTODOS: Foram avaliadas 16 pacientes com HAC-C-D21OH e 26 controles, todas do sexo feminino, com idades de 8 a 18 anos. Foram estimadas as massas gorda (MG) e magr (more) a (MM) utilizando EDC e BIA. Os dados das MG e MM foram analisados de forma relativa (%), absoluta (kg) e em relação à estatura (IMG e IMM). RESULTADOS: Não foram encontradas diferenças significativas entre os dois métodos em cada grupo avaliado. Em relação ao grupo controle, as pacientes com HAC-C-D21OH apresentaram valores maiores de MG (%) BIA, IMG BIA e IMM EDC e menores de MM (%) BIA. Foi verificada correlação positiva e alta em todos os parâmetros analisados. CONCLUSÃO: Os resultados observados pelos métodos de EDC e BIA foram semelhantes nesta amostra de mulheres com HAC-CD21OH, porém controversos em relação ao grupo controle, sugerindo que se tenha cautela no uso desses métodos de avaliação da composição corporal nessa população. Abstract in english OBJECTIVE: To estimate body composition by evaluating skinfold thickness (ST) and electric bioimpedance (EB) in a group of women with congenital adrenal hyperplasia due to classical 21-hydroxylase deficiency (CAH-C-21OHD) in relation to a control group. SUBJECTS AND METHODS: Sixteen patients and 26 controls were evaluated, all female, with age varying from 8 to 18 years. Fat (FM) and lean (LM) masses were evaluated by ST and EB. FM and LM data were analyzed in relative (% (more) ) and absolute (kg) values, and in relation to stature (FMI and LMI). RESULTS: There were no observed significant differences between the two methods in each group. In relation to the control group, CAH-C-21OHD patients showed higher values for FM (%) EB, FMI EB and LMI ST but lower values for FM (%) EB. Positive and high correlation values were observed for all parameters analyzed. CONCLUSION: ST and EB results observed were similar in this sample of females with CAH-C-21OHD, but controversial in relation to the control group, suggesting caution when using these methods to evaluate body composition in this population.

Gonçalves, Ezequiel Moreira; Lemos-Marini, Sofia Helena Valente de; Mello, Maricilda Palandi de; Baldin, Alexandre Duarte; Carvalho, Wellington Roberto Gomes; Farias, Edson Santos; Guerra-Júnior, Gil

2010-03-01

330

Comparison of bioimpedance analysis and dual-energy X-ray absorptiometry body composition measurements in peritoneal dialysis patients according to edema.  

UK PubMed Central (United Kingdom)

BACKGROUND: Changes in the difference between bioimpedance analysis (BIA) and dual-energy X-ray absorptiometry (DXA) body composition measurements according to edema is an important issue for peritoneal dialysis (PD) patients. METHODS: We reviewed the medical records of patients to identify all adults who had undergone PD and composition measurements by both BIA and DXA techniques. The aim of this study was to evaluate any change in the difference between BIA and DXA body composition measurements according to edema. RESULTS: We identified 409 patients whose body compositions were measured by both techniques one or more times, for a total of 1,109 pairs of measurements. The measurements were divided into 4 quartiles on the basis of the edema index. Significant correlations and intraclass correlations were noted between the two methods for lean mass (LM), fat mass (FM), and bone mineral content. Simple linear regression analyses using DXA measurements for the prediction of body compositions by BIA showed that non-standardized-?s of total LM decreased as the grade of edema index increased (from 1.008 to 0.949), whereas non-standardized-?s of total FM increased as the grade of edema index increased (from 1.034 to 1.162). Bias for total LM changed from positive to negative, and this negative bias amplified as the grade of edema index escalated (from 0.406 kg to -2.276 kg). A positive bias was observed for total FM in the 1st quartile, and this positive bias increased with an increase in the grade of edema index (from 0.594 kg to 2.863 kg). CONCLUSION: LM measured by DXA is overestimated in PD patients with edema compared to the measurements by BIA. However, FM and bone mineral content measured by BIA are is overestimated in PD patients, compared to the measurements by DXA, especially in patients with worsening edema. The difference between the two techniques grows more prominent as the grade of edema increases. A combination of two methods will allow clinicians to conduct more accurate body composition assessments for PD patients with edema.

Kang SH; Cho KH; Park JW; Yoon KW; Do JY

2013-04-01

331

Porównanie metod pomiaru odsetka tkanki t?uszczowej u dzieci  

Directory of Open Access Journals (Sweden)

Full Text Available Wprowadzenie: W ostatnich latach wzros?a cz?sto?? wyst?powania oty?o?ci i nadwagi w populacji wieku rozwojowego. Nast?pstwa oty?o?ci, wyst?puj?ce pod postaci? chorób uk?adu sercowo naczyniowego oraz cukrzycy typu 2 i wynikaj? po?rednio z zaburze? funkcji tkanki t?uszczowej i poprzez to zwracaj? uwag? na celowo?? pomiaru odsetka tkanki t?uszczowej w organizmie w?ród dzieci i m?odzie?y. Celem pracy by?o porównanie wyników pomiaru zawarto?ci masy tkanki t?uszczowej u dzieci metod? impedancji bioelektrycznej (BIA) i badaniem antropometrycznym z metod? referencyjn? – densytometri? (DXA). Materia? i metody: Badania przeprowadzono u 56 dzieci w wieku 6-18 lat. U wszystkich wykonano pomiary antropometryczne zgodnie z przyj?tymi metodami. Pomiar odsetka tkanki t?uszczowej dokonano z zastosowaniem densytometrii, impedancji bioelektrycznej oraz metod? antropometryczn? na podstawie pomiarów fa?dów skórno-t?uszczowych wykorzystuj?c algorytm Slaughtera. Badanie densytometryczne przeprowadzono metod? absorpcjometrii promieniowania rentgenowskiego o podwójnej energii (DXA). Analizy impedancji bioelektrycznej (BIA) dokonano przy u?yciu wagi firmy Tanita z wbudowanym systemem o?mioelektrodowym. Wyniki: Wspó?czynnik r2 dla zgodno?ci mi?dzy wynikami DXA a BIA wynosi? r2=0,83, a mi?dzy DXA i metod? Slaughtera r2=0,83 (p <0,001). Wszystkie metody charakteryzowa?y si? du?? precyzj?, odnotowano jednak ró?nice mi?dzy wynikami uzyskanymi ró?nymi metodami. BIA oraz metoda Slaughtera zwykle zani?a?a procentow? zawarto?? t?uszczu w organizmie, a niedoszacowanie stawa?o si? wi?ksze wraz z wielko?ci? tej cechy. Ró?nice w pomiarach mi?dzy BIA i metod? Slaughtera a DXA negatywnie korelowa?y z warto?ci? BMI SDS i obwodem talii – SDS. Nie stwierdzono zale?no?ci od wieku pacjenta. Wnioski: Zastosowanie metody BIA lub metody Slaughtera do oceny ilo?ci t?uszczu w organizmie u dzieci pozwala na uzyskanie dok?adnych wyników, jednak zani?onych w stosunku do DXA. Z tego powodu przy monitorowaniu zmian odsetka tkanki t?uszczowej w organizmie nale?y stosowa? t? sam? metod? pomiaru.

El?bieta Jakubowska-Pietkiewicz; Alicja Prochowska; Wojciech Fendler; Agnieszka Szadkowska

2009-01-01

332

Concordancia entre los porcentajes de grasa corporal estimados mediante el área adiposa del brazo, el pliegue del tríceps y por impedanciometría brazo-brazo  

Directory of Open Access Journals (Sweden)

Full Text Available Fundamento: La valoración del estado nutricional a partir de los miembros superiores es útil a nivel clínico. El objetivo de este trabajo es analizar el grado de acuerdo entre los porcentajes de grasa corporal (%GC) estimados mediante el área adiposa del brazo (%GC BRAZO), la ecuación de Siri para el pliegue del tríceps (%GC TRÍCEPS) y por bioimpedanciometría brazo-brazo (%GC BIA), así como con la ecuación de Siri para cuatro pliegues (%GC SIRI). Métodos: Estudio descriptivo transversal. Se valoró antropométricamente y por impedanciometría (Omron BF 300©) a 145 personas (83 varones, 62 mujeres). La concordancia entre métodos se analizó mediante el coeficiente de correlación intraclase (CCI) y el método de Bland-Altman. Resultados: el CCI entre %GC BRAZO-%GC TRÍCEPS fue de 0,8322 (intervalo de confianza al 95% 0,7672-0,8791); entre %GCB RAZO-%GC BIA de 0,7337 (0,6305-0,8080) y entre %GC TRICEPS-%GC BIA de 0,9290 (0,9015; 0,9488). Con el método de Bland-Altman el intervalo de concordancia entre %GC BRAZO-%GC TRÍCEPS (-11,2; 16,96) y entre %GC BRAZO-%GC BIA (-13,04; 21,76) superó el punto de corte (±10%), pero no entre %G CTRICEPS-%GC BIA (-6,64; 9,6), %GC SIRI-%GC TRÍCEPS (-5,27; 4,52) y %GC SIRI-%GC BIA (-6,31; 8,52). El IMC no influyó en el resultado. Conclusiones: El método utilizado influye en la valoración nutricional realizada a partir de los miembros superiores. El área adiposa del brazo sobreestima el %GC con relación a la ecuación de Siri para el pliegue del tríceps o para cuatro pliegues y a la impedanciometría, y aunque este resultado sugiere que el área adiposa del brazo puede no ser un indicador válido de la adiposidad global, este extremo deberá ser confirmado frente a una técnica patrón.

Martín Moreno Vicente; Gómez Gandoy Juan Benito; Antoranz González María Jesús; Gómez de la Cámara Agustín

2003-01-01

333

Composição corporal em mulheres com deficiência da 21-hidroxilase: comparação dos métodos antropométricos e de impedância bioelétrica em relação a um grupo controle Body composition in females with 21-hydroxylase deficiency: comparison of anthropometric methods and bioelectric impedance in relation to a control group  

Directory of Open Access Journals (Sweden)

Full Text Available OBJETIVO: Estimar a composição corporal avaliada pela espessura de dobras cutâneas (EDC) e pela impedância bioelétrica (BIA) em um grupo de mulheres com hiperplasia adrenal congênita, forma clássica por deficiência da enzima 21-hidroxilase (HAC-C-D21OH) e em relação ao um grupo controle. PACIENTES E MÉTODOS: Foram avaliadas 16 pacientes com HAC-C-D21OH e 26 controles, todas do sexo feminino, com idades de 8 a 18 anos. Foram estimadas as massas gorda (MG) e magra (MM) utilizando EDC e BIA. Os dados das MG e MM foram analisados de forma relativa (%), absoluta (kg) e em relação à estatura (IMG e IMM). RESULTADOS: Não foram encontradas diferenças significativas entre os dois métodos em cada grupo avaliado. Em relação ao grupo controle, as pacientes com HAC-C-D21OH apresentaram valores maiores de MG (%) BIA, IMG BIA e IMM EDC e menores de MM (%) BIA. Foi verificada correlação positiva e alta em todos os parâmetros analisados. CONCLUSÃO: Os resultados observados pelos métodos de EDC e BIA foram semelhantes nesta amostra de mulheres com HAC-CD21OH, porém controversos em relação ao grupo controle, sugerindo que se tenha cautela no uso desses métodos de avaliação da composição corporal nessa população.OBJECTIVE: To estimate body composition by evaluating skinfold thickness (ST) and electric bioimpedance (EB) in a group of women with congenital adrenal hyperplasia due to classical 21-hydroxylase deficiency (CAH-C-21OHD) in relation to a control group. SUBJECTS AND METHODS: Sixteen patients and 26 controls were evaluated, all female, with age varying from 8 to 18 years. Fat (FM) and lean (LM) masses were evaluated by ST and EB. FM and LM data were analyzed in relative (%) and absolute (kg) values, and in relation to stature (FMI and LMI). RESULTS: There were no observed significant differences between the two methods in each group. In relation to the control group, CAH-C-21OHD patients showed higher values for FM (%) EB, FMI EB and LMI ST but lower values for FM (%) EB. Positive and high correlation values were observed for all parameters analyzed. CONCLUSION: ST and EB results observed were similar in this sample of females with CAH-C-21OHD, but controversial in relation to the control group, suggesting caution when using these methods to evaluate body composition in this population.

Ezequiel Moreira Gonçalves; Sofia Helena Valente de Lemos-Marini; Maricilda Palandi de Mello; Alexandre Duarte Baldin; Wellington Roberto Gomes Carvalho; Edson Santos Farias; Gil Guerra-Júnior

2010-01-01

334

Source Assessment and Analysis of Polycyclic Aromatic Hydrocarbon (PAH’s) in the Oblogo Waste Disposal Sites and Some Water Bodies in and around the Accra Metropolis of Ghana  

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Full Text Available The study looked at the levels of polycyclic aromatic hydrocarbons (PAHs) in leachates from a solid waste disposal site and an effluent from an oil refinery in some water bodies around Accra. Sixteen (PAHs) were extracted simultaneously by solid phase and analysis by gas chromatograph. The results of this study gener-ally demonstrated that there were elevated levels of PAHs in the water sample of the Densu River, Chemu, Korle and Kpeshi Lagoons. The average concentration of PAHs in the water ranged from 0.000 of many of the PAHs to 0.552µg/L, for Acenapththene to 11.399µg/L for Benzo (ghi) perylene of the Chemu Lagoon, 0.00µg/L for Benzo (a) Pyrene to 8.800µg/L for Benzo (ghi) perylene (Korle Lagoon) and 0.052µg/L for Pyrene to 4.703ug/L for Acenaphthylene of the Kpeshi Lagoon and 0.00µg/L for pyrene to Acenaphthylene 2.926µg/L of the Weija Dam. Concentrations ranging from below detection level to 14.587µg/L were also recorded at the Oblogo solid waste dump and it’s environ. The Weija dam supply over two million gallons of portable water daily to the people of Accra and the levels of the PAH determined is worrying, as a result, the Oblogoh disposal site ought to be re-located to avert any possible epidemic.

David Kofi ESSUMANG; Christian. Kweku ADOKOH; Joseph AFRIYIE; Esther MENSAH

2009-01-01

335

Global horizontal irradiance clear sky models : implementation and analysis.  

Energy Technology Data Exchange (ETDEWEB)

Clear sky models estimate the terrestrial solar radiation under a cloudless sky as a function of the solar elevation angle, site altitude, aerosol concentration, water vapor, and various atmospheric conditions. This report provides an overview of a number of global horizontal irradiance (GHI) clear sky models from very simple to complex. Validation of clear-sky models requires comparison of model results to measured irradiance during clear-sky periods. To facilitate validation, we present a new algorithm for automatically identifying clear-sky periods in a time series of GHI measurements. We evaluate the performance of selected clear-sky models using measured data from 30 different sites, totaling about 300 site-years of data. We analyze the variation of these errors across time and location. In terms of error averaged over all locations and times, we found that complex models that correctly account for all the atmospheric parameters are slightly more accurate than other models, but, primarily at low elevations, comparable accuracy can be obtained from some simpler models. However, simpler models often exhibit errors that vary with time of day and season, whereas the errors for complex models vary less over time.

Stein, Joshua S.; Hansen, Clifford W.; Reno, Matthew J.

2012-03-01

336

A transfer function for the prediction of gas hydrate inventories in marine sediments  

Directory of Open Access Journals (Sweden)

Full Text Available A simple prognostic tool for gas hydrate (GH) quantification in marine sediments is presented based on a diagenetic transport-reaction model approach. One of the most crucial factors for the application of diagenetic models is the accurate formulation of microbial degradation rates of particulate organic carbon (POC) and the coupled biogenic CH4 formation. Wallmann et al. (2006) suggested a kinetic formulation considering the ageing effects of POC and accumulation of reaction products (CH4, CO2) in the pore water. This model is applied to data sets of several ODP sites in order to test its general validity. Based on a thorough parameter analysis considering a wide range of environmental conditions, the POC accumulation rate (POCar in g/cm2/yr) and the thickness of the gas hydrate stability zone (GHSZ in m) were identified as the most important and independent controls for biogenic GH formation. Hence, depth-integrated GH inventories in marine sediments (GHI in g of CH4 per cm2 seafloor area) can be estimated as: GHI = a · POCar · GHSZb · exp (?GHSZc/POCar/d) + e with a = 0.00214, b = 1.234, c = ?3.339, d = 0.3148, e = ?10.265. Several tests indicate that the transfer function gives a realistic approximation of the minimum potential GH inventory of low gas flux (LGF) systems. The overall advantage of the presented function is its simplicity compared to complex numerical models: only two easily accessible parameters are needed.

M. Marquardt; C. Hensen; E. Piñero; K. Wallmann; M. Haeckel

2010-01-01

337

A transfer function for the prediction of gas hydrate inventories in marine sediments  

Science.gov (United States)

A simple prognostic tool for gas hydrate (GH) quantification in marine sediments is presented based on a diagenetic transport-reaction model approach. One of the most crucial factors for the application of diagenetic models is the accurate formulation of microbial degradation rates of particulate organic carbon (POC) and the coupled formation of biogenic methane. Wallmann et al. (2006) suggested a kinetic formulation considering the ageing effects of POC and accumulation of reaction products (CH4, CO2) in the pore water. This model is applied to data sets of several ODP sites in order to test its general validity. Based on a thorough parameter analysis considering a wide range of environmental conditions, the POC accumulation rate (POCar in g/m2/yr) and the thickness of the gas hydrate stability zone (GHSZ in m) were identified as the most important and independent controls for biogenic GH formation. Hence, depth-integrated GH inventories in marine sediments (GHI in g of CH4 per cm2 seafloor area) can be estimated as: GHI = a · POCar · GHSZb · exp (- GHSZc/POCar/d) + e with a = 0.00214, b = 1.234, c = -3.339, d = 0.3148, e = -10.265. The transfer function gives a realistic first order approximation of the minimum GH inventory in low gas flux (LGF) systems. The overall advantage of the presented function is its simplicity compared to the application of complex numerical models, because only two easily accessible parameters need to be determined.

Marquardt, M.; Hensen, C.; Piñero, E.; Wallmann, K.; Haeckel, M.

2010-09-01

338

A transfer function for the prediction of gas hydrate inventories in marine sediments  

Directory of Open Access Journals (Sweden)

Full Text Available A simple prognostic tool for gas hydrate (GH) quantification in marine sediments is presented based on a diagenetic transport-reaction model approach. One of the most crucial factors for the application of diagenetic models is the accurate formulation of microbial degradation rates of particulate organic carbon (POC) and the coupled formation of biogenic methane. Wallmann et al. (2006) suggested a kinetic formulation considering the ageing effects of POC and accumulation of reaction products (CH4, CO2) in the pore water. This model is applied to data sets of several ODP sites in order to test its general validity. Based on a thorough parameter analysis considering a wide range of environmental conditions, the POC accumulation rate (POCar in g/m2/yr) and the thickness of the gas hydrate stability zone (GHSZ in m) were identified as the most important and independent controls for biogenic GH formation. Hence, depth-integrated GH inventories in marine sediments (GHI in g of CH4 per cm2 seafloor area) can be estimated as: GHI = a · POCar · GHSZb · exp (– GHSZc/POCar/d) + e with a = 0.00214, b = 1.234, c = –3.339,         d = 0.3148, e = –10.265. The transfer function gives a realistic first order approximation of the minimum GH inventory in low gas flux (LGF) systems. The overall advantage of the presented function is its simplicity compared to the application of complex numerical models, because only two easily accessible parameters need to be determined.

M. Marquardt; C. Hensen; E. Piñero; K. Wallmann; M. Haeckel

2010-01-01

339

'Health transformation programme' in Turkey: an assessment.  

UK PubMed Central (United Kingdom)

The aim of this study is to assess the 'Health Transformation Programme' (HTP) in Turkey announced in 2003. This assessment has been made according to the ultimate performance goals of a health care system, such as improvement in health status, financial risk protection and satisfaction with health care. This study provides a brief history of health policy since 1980, when the Turkish health care system began to transform with the introduction of both structural adjustment and market-oriented reform policy. The main aim of these reforms was increasing efficiency. Reform proposals of the 1990s focused on the introduction of a general health insurance (GHI) system, decentralization, introduction of a family medicine scheme, purchaser-provider split, contracting-out, quasi-markets and improvement of management information systems. Like the reform proposals of the 1990s, HTP has eight components, the major ones being a new role for the Ministry of Health (MoH), introduction of a GHI system, reorganization of health service delivery and human resources development. No component of HTP has yet been sufficiently realized. Therefore, despite some improvements, Turkish people continue to face low health status and a low level of financial risk protection. More research needs to be done for the determination of satisfaction with health services.

Yasar GY

2011-04-01

340

'Health transformation programme' in Turkey: an assessment.  

Science.gov (United States)

The aim of this study is to assess the 'Health Transformation Programme' (HTP) in Turkey announced in 2003. This assessment has been made according to the ultimate performance goals of a health care system, such as improvement in health status, financial risk protection and satisfaction with health care. This study provides a brief history of health policy since 1980, when the Turkish health care system began to transform with the introduction of both structural adjustment and market-oriented reform policy. The main aim of these reforms was increasing efficiency. Reform proposals of the 1990s focused on the introduction of a general health insurance (GHI) system, decentralization, introduction of a family medicine scheme, purchaser-provider split, contracting-out, quasi-markets and improvement of management information systems. Like the reform proposals of the 1990s, HTP has eight components, the major ones being a new role for the Ministry of Health (MoH), introduction of a GHI system, reorganization of health service delivery and human resources development. No component of HTP has yet been sufficiently realized. Therefore, despite some improvements, Turkish people continue to face low health status and a low level of financial risk protection. More research needs to be done for the determination of satisfaction with health services. PMID:21674612

Yasar, Gulbiye Yenimahalleli

2010-10-27

 
 
 
 
341

Accuracy of field methods in assessing body fat in collegiate baseball players.  

UK PubMed Central (United Kingdom)

When assessing the fitness levels of athletes, body composition is usually estimated, as it may play a role in athletic performance. Therefore, the purpose of this study was to determine the validity of bioelectrical impedance analysis (BIA) and skinfold (SKF) methods compared with dual-energy X-ray absorptiometry (DXA) for estimating percent body fat (%BF) in Division 1 collegiate baseball players (n?=?35). The results of this study indicate that the field methods investigated were not valid compared with DXA for estimating %BF. In conclusion, this study does not support the use of the TBF-350, HBF-306, HBF-500, or SKF thickness for estimating %BF in collegiate baseball players. The reliability of these BIA devices remains unknown; therefore, it is currently uncertain if they may be used to track changes over time.

Loenneke JP; Wray ME; Wilson JM; Barnes JT; Kearney ML; Pujol TJ

2013-01-01

342

Quantitative detection for plant virus's RNA-loading by dot-blot  

International Nuclear Information System (INIS)

A new method, RNA dot blot combined with direct determination of the radioactivity by BIO-Imaging Analyzer (dRH-dBIA) was used for detecting RNA of plant virus in infected plant tissue. This method was used for the influence of RNA-loading level of tobacco mosaic virus (TMV) in tobacco leave tissues after treatment of a plant hormone relatives (n-Propyl dihydro-jasmonate, PDJ) in the concentration range of 0.001-10 ppm. The results indicate that after PDJ application onto tobacco leaves for 3 days all PDJ treatments cause increase of TMV RNA-loading level except 0.001 ppm treatment, and the higher the concentration, the more obvious increase was observed. This phenomenon was confirmed with semi-leaf lesion spot on Nicotiana glutinosa as a local lesion host. The dRH-dBIA method is applicable in quantitative determination of RNA without obvious artificial influence

2003-01-01

343

Controllable manipulation of structure inversion asymmetry (SIA) of quantum wells (QWs) by shifting the position of {delta}-doping layer  

Energy Technology Data Exchange (ETDEWEB)

We demonstrate that the growing of semiconductor QWs with various {delta}-doping layer positions accompanied by measurements of magnetogyrotropic photogalvanic effect (MGPE) allows the controle of SIA. The MPGE originates from bulk inversion asymmetry (BIA) and SIA and therefore reflects their behaviour. We show that for a proper experimental geometry, currents measured along and perpendicular to B, are proportional to BIA and SIA, respectively. Our experiments prove that shifting the {delta}-doping layer from one side of the QW to the other results in a change of sign of the SIA-caused MPGE. Our measurements show that while nominally symmetrically doped (001)-grown structures have an essential structural asymmetry, (110)-grown structures are almost symmetrical. Our results allow the growth of perfectly symmetric structures without Rashba constant and structures with equal Rashba and Dresselhaus spin splittings. Experiments were carried out at room temperature on n-type GaAs quantum wells.

Lechner, V.; Ganichev, S.D.; Olbrich, P.; Schuh, D.; Wegscheider, W.; Weiss, D.; Prettl, W. [Terahertz Center, University of Regensburg (Germany); Belkov, V.V.; Golub, L.E.; Tarasenko, S.A. [A.F. Ioffe Physico-Technical Institute, Russian Academy of Sciences, St. Petersburg (Russian Federation)

2009-07-01

344

Pharmaceutical Applications of the Benzylisoquinoline Alkaloids from Argemone mexicana L.  

UK PubMed Central (United Kingdom)

Argemone mexicana L. (Papaveraceae), accumulates benzylisoquinoline alkaloids, (BIA) derived from tyrosine. Although it was originated in the western region of the USA-Mexico border, it has spread to tropical and subtropical areas around the world. Today, it is used to treat different ailments, given to its antimicrobial, antiparasitic, antimalarial, pesticide, cytotoxic and neurological properties. These effects are related to the presence of different types of BIA's, such as benzophenanthridines (sanguinarine, chelerythrine), protoberberines (berberine) and protopines (protopine, allocryptopine). This review covers the historical medicinal uses of A. mexicana, as well as its current applications. The chemical bases of such effects are discussed in relation to the occurrence of the different types of alkaloids. The biochemical process involved in the synthesis of these types of alkaloids is also described.

Rubio-Pina J; Vazquez-Flota F

2013-01-01

345

Development of Optical Fiber Technology in Poland, International Journal of Electronics and Telecommunication, vol. 57, no 2, pp.191-197, July 2011  

CERN Multimedia

In this paper, the authors, chairmen of the 13th Conference on Optical Fibers and Their Applications OFA2011, and editors of the conference proceedings summarize the development of optical fiber technology in Poland (during the period of 2009- 2011) on the basis of papers presented there and consecutively published in this volume. The digest is thus not full but covers the periodically presented material every 18 months during the meetings on optical fibers in Bia?ystok-Bia?owie?za and Lublin- Krasnobród. OFC systems are developed for HEP experiments and accelerators. OFC systems are also developed for virtual atomic clocks. EuCARD information presentation was organized during this meeting. Keywords— optical fibers, optical communication systems, photonic sources and detectors, photonic sensors, integrated optics, photonics applications, photonic materials.

Dorosz, J

2011-01-01

346

Industrial Injuries Insurance Institutes' measuring programme of technical supervising for protection against dusts and gases at the work place  

Energy Technology Data Exchange (ETDEWEB)

Together with the Industrial Insurance Institutes the Berufsgenossenschaftliches Institut fuer Arbeitssicherheit - BIA (Occupational Safety Institute of Industrial Injuries Insurance Institutes) has built up a supervising programme for the employees' protection against noxious dusts, gases and fumes. In the course of this programme more than 65 000 measurements were taken at workplaces within nearly 10 years, especially in cases of noxious dusts involved, and more than 130 000 substance analyses were made. On the whole, 13 600 tests at workplaces could be analysed at the BIA in 1981. The development and efficiency of the supervising programme, where the Industrial Injuries Insurance Institutes takes samples of noxious substances at industrial workplaces and later analyse them, is described, and possibilities for the further development of this programme are shown.

Coenen, W.

1982-03-01

347

Bureau of Indian Affairs' participation in a proposed hydroelectric facility at Kootenai Falls, Montana  

Energy Technology Data Exchange (ETDEWEB)

In 1980 the Bureau of Indian Affairs (BIA) agreed with a group of seven electric cooperatives that it would pay up to a 10.5% share of the costs to determine the feasibility of, and obtain a construction and operation license for, a proposed hydroelectric generating facility at Kootenai Falls, Montana. This report discusses how the BIA improperly spent Flathead Indian Reservation Irrigation and Power Project revenues and did not report to congressional appropriations committees its reprogramming of irrigation and power system construction funds to pay a portion of its share of Kootenai Falls participation expenses. Also, the Flathead project's financial system was not in compliance with two of the Comptroller General's internal control standards. The Department of the Interior has initiated or plans actions to correct the problems identified in this report.

1984-07-11

348

Pharmaceutical Applications Of The Benzylisoquinoline Alkaloids From Argemone Mexicana L.  

UK PubMed Central (United Kingdom)

Argemone mexicana L. (Papaveraceae), accumulates benzylisoquinoline alkaloids, (BIA) derived from tyrosine. Although it was originated in the western region of the USA-Mexico border, it has spread to tropical and subtropical areas around the world. Today, it is used to treat different ailments, given to its antimicrobial, antiparasitic, antimalarial, pesticide, cytotoxic and neurological properties. These effects are related to the presence of different types of BIA's, such as benzophenanthridines (sanguinarine, chelerythrine), protoberberines (berberine) and protopines (protopine, allocriptopine). This review covers the historical medicinal uses of A. mexicana, as well as its current applications. The chemical bases of such effects are discussed in relation to the occurrence of the different types of alkaloids. The biochemical process involved in the synthesis of these types of alkaloids is also described.

Rubio-Piña J; Vázquez-Flota F

2013-08-01

349

Anthropometric methods for obesity screening in schoolchildren: the Ouro Preto Study Métodos de antropometría para la detección de obesidad en escolares: el estudio de Ouro Preto  

Directory of Open Access Journals (Sweden)

Full Text Available Background and aims: Childhood obesity is increasing dramatically in last decades. To evaluate the usefulness of body mass index (BMI), skinfold thickness (ST), waist circumference (WC), and foot-to-foot bioelectrical impedance (BIA-FF) for screening for obesity in mixed-race popu lation, using the tetrapolar bioelectrical impedance (BIA-T) technique as reference method. Methods and results: A cross-sectional-based population study was performed in the city of Ouro Preto, Brazil, in 2006. Schoolchildren aged 6-15 years (n = 788) was randomly selected according to age and sex stratified by the proportion of students in each schools of the city. Nonparametric receiver operating characteristic (ROC) analysis was used to define the sensitivity and specificity for each method studied using the tetrapolar method as reference. The BMI and the BIA-FF were the most suitable for adiposity screening in pre-pubertal and pubertal stages because they present a better balance between sensitivity and specificity, and smaller misclassification. For post-pubertal boys, the BF-ST-D was the best body fat assessment method. Conclusion: The results suggest that BIA-FF and BMI are choice methods for obesity screening in mixed population and that the method choice for body fat screening must be done according to sexual maturity of boys and girls. The present study demonstrates the need to perform studies in wider mixed-race population to determine anthropometric parameters and to examine the predictive ability of methods and cut-offs here elucidated in the development of obesity.Antecedentes y objetivos: La obesidad infantil está aumentando alarmantemente en las últimas décadas. Para evaluar la utilidad del índice de masa corporal (IMC), el grosor del pliegue cutáneo (GPC), la circunferencia de la cintura (CC), y la impedancia bioeléctrica pie-a-pie (BIA-PP) para el cribado de la obesidad en poblaciones con diversidad de razas utilizando una técnica de impedancia bioeléctrica tetrapolar (BIA-T) como el método de referencia. Métodos y resultados: se realizó un estudio transversal poblacional in la ciudad de Ouro Preto, Brasil, en el 2006. Se distribuyó al azar a escolares de 6-15 años (n = 788), que se seleccionaron en función de la edad y el sexo, estratificados por la proporción de estudiantes en cada colegio de la ciudad. Se utilizó un análisis no paramétrico de curvas ROC para definir la sensibilidad y la especificidad para cada método estudiado empleando el método tetrapolar como referencia. El IMC y la BIA-PP fueron los más idóneos para el cribado de la obesidad en las etapas prepuberales y puberales puesto que presentan un equilibrio mejor entre la sensibilidad y la especificidad y un menor fallo de clasificación. Para los niños prepúberes, el BF-GPC-D fue el mejor método de evaluación de la grasa corporal. Conclusión: Los resultados sugieren que la BIA-PP y el IMC son los métodos de elección para el cribado de la obesidad en poblaciones mixtas y que el método de elección para el cribado de la grasa corporal debe realizarse de acuerdo con la madurez sexual de los chicos y chicas. Este estudio demuestra la necesidad de realizar estudios en poblaciones mixtas más amplias para determinar los parámetros antropológicos y examinar la capacidad predictiva de los métodos y los puntos de corte obtenidos aquí en el desarrollo de la obesidad.

A. P. C. Cándido; J. P. S. Alosta; C. T. Oliveira; R. N. Freitas; S. N. Freitas; G. L. L. Machado-Coelho

2012-01-01

350

Znaczenie markera NGAL w diagnostyce powik?a? nerkowych w przebiegu chorób kardiologicznych  

Directory of Open Access Journals (Sweden)

Full Text Available Wprowadzenie do diagnostyki nowych biomarkerów uszkodzenia kanalików nerkowych: NGAL (neutrophil gelatinase associated lipocalin), KIM-1 (kidney injury molecule-1), bogatego w cystein? bia?ka 61, cystatyny C, interleukiny-18 i innych bia?ek (1-6) umo?liwia bardzo wczesne rozpoznanie ostrej niewydolno?ci nerek. W zwi?zku z cz?stymi powik?aniami nerkowymi, spowodowanymi np. pokontrastowym uszkodzeniem nerek, oraz ze znan? zale?no?ci? mi?dzy schorzeniami kardiologicznymi i wywo?an? przez nie dysfunkcj? nerek rozpocz?to próby zaadaptowania kilku dobrze scharakteryzowanych markerów do wczesnej diagnostyki uszkodzenia nerek u pacjentów leczonych z powodu chorób uk?adu kr??enia. Spo?ród du?ej grupy znanych markerów NGAL wykazuje si? najwy?szym znaczeniem diagnostycznym ze wzgl?du na bardzo szybki okres reakcji na uszkodzenie kanalików. Jest to szczególnie istotne z powodu nieustannego skracania pobytu pacjenta po zabiegu w szpitalu.

Grzegorz Cichosz; Micha? Kidawa

2011-01-01

351

Phenotypic variation of Epipactis helleborine x E. atrorubens hybrids in anthropogenic conditions  

Directory of Open Access Journals (Sweden)

Full Text Available Hybrid index has revealed the hybrid nature of helleborine populations growing on disturbed habitats in Bia?owie?a Forest and its western foreland. An analysis of eight traits has revealed that hybrids are morphologically more similar to E. helleborine. Hybrids differ from the typical E. helleborine first of all by: a very pubescent inflorescence axis, a considerable length of the subinflorescence internode. Also the range of phenotypical variation in these populations is shown.

Wojciech Adamowski

1995-01-01

352

The application of bioelectrical impedance analysis in live tropical hair sheep as a predictor of body composition upon slaughter.  

UK PubMed Central (United Kingdom)

Animal management for breeding and marketing can be improved by precise measurement of desirable traits. Live animal body composition analysis facilitates the selection of animals that are best suited for the intended purpose. This study was designed to assess the accuracy of bioelectrical impedance analysis (BIA) predicted live body tissue composition, as a proxy for the estimation of carcass quality in Barbados Black Belly lambs. Thirty-four Barbados Black Belly lambs were placed on an 8-week feeding regime and then slaughtered. A randomized experimental design was used to allocate diets to animals, which had been stratified into eight groups by initial live weight. The lambs were fed a basal diet of Brachiaria arrecta fresh forage ad libitum and subjected to one of four diets; NS-non-supplemented diet, TG-Trichantera gigantea-supplemented, C100-concentrate supplemented for maintenance, and C400-concentrate supplemented for growth. Diets NS, TG, C100, and C400 had 7, 9, 11, and 7 animals, respectively. The average age and weight at the time of slaughter were 206 days and 23.7 kg, respectively. A 4-terminal impedance analyzer (RJL Systems®) was used to generate BIA data from live animals immediately before slaughter. The chilled carcasses were then subject to chemical analysis for crude fat, crude protein, and dry matter. Live animal and carcass traits predicted by BIA included fat and fat-free mass, crude fat, crude protein, protein to fat ratio, and tissue distribution. Regression equations were developed from BIA data obtained from the live animal to predict all carcass composition traits measured. Bioelectrical impedance analysis generated favorable results as a practical application to carcass composition evaluation in live tropical hair sheep.

Avril DH; Lallo C; Mlambo V; Bourne G

2013-07-01

353

Skinfold Anthropometry -The Accurate Method for Fat Free Mass Measurement in COPD.  

Science.gov (United States)

Abstract Purpose: Fat free mass index (FFMI) is an independent predictor of metabolic and functional consequences in COPD. For its measurement dual energy X-ray absorptiometry (DEXA), skin-fold anthropometry (SFA), bioelectrical impedance analysis (BIA) and bioimpedance spectroscopy (BIS) are used in clinical practice. The aim of our pilot study was to analyse precisely and critically which method is most accurate and available for common use in clinical practice for measurement of FFM by assessment against relevant DEXA in patients with COPD. Methods: This was an observational cross-sectional study of consecutive COPD subjects. FFM by methods of SFA, two versions of BIA, and BIS was compared with that from clinically relevant DEXA in 41 outpatients (mean age 66.5 ± 7.7 yrs) with stable COPD, 34 men and 7 women, with mean BMI 28.2 ± 6.1 kg.m(-2). Results: All methods underestimate FFM in comparison with DEXA. In the general evaluation non-significant differences with the smallest mean bias were demonstrated for SFA (1.2 kg) and BIA (3.8 kg), but there was a difference of more than 9 kg using BIS and BIA COPD methods (p < 0.0001). The best agreement between DEXA and SFA was demonstrated via Lin's concordance coefficient and Bland-Altman test. Conclusions: SFA has been demonstrated as an accurate, available and cheap method for determination of FFM and FM with application of the Durnin Womersley equation for body density and with the Siri equation for FM in patients with COPD. SFA can be easily applied in routine clinical practice. PMID:23844827

Hronek, Miloslav; Kovarik, Miroslav; Aimova, Petra; Koblizek, Vladimir; Pavlikova, Ladislava; Salajka, Frantisek; Zadak, Zdenek

2013-07-11

354

Skinfold Anthropometry -The Accurate Method for Fat Free Mass Measurement in COPD.  

UK PubMed Central (United Kingdom)

Abstract Purpose: Fat free mass index (FFMI) is an independent predictor of metabolic and functional consequences in COPD. For its measurement dual energy X-ray absorptiometry (DEXA), skin-fold anthropometry (SFA), bioelectrical impedance analysis (BIA) and bioimpedance spectroscopy (BIS) are used in clinical practice. The aim of our pilot study was to analyse precisely and critically which method is most accurate and available for common use in clinical practice for measurement of FFM by assessment against relevant DEXA in patients with COPD. Methods: This was an observational cross-sectional study of consecutive COPD subjects. FFM by methods of SFA, two versions of BIA, and BIS was compared with that from clinically relevant DEXA in 41 outpatients (mean age 66.5 ± 7.7 yrs) with stable COPD, 34 men and 7 women, with mean BMI 28.2 ± 6.1 kg.m(-2). Results: All methods underestimate FFM in comparison with DEXA. In the general evaluation non-significant differences with the smallest mean bias were demonstrated for SFA (1.2 kg) and BIA (3.8 kg), but there was a difference of more than 9 kg using BIS and BIA COPD methods (p < 0.0001). The best agreement between DEXA and SFA was demonstrated via Lin's concordance coefficient and Bland-Altman test. Conclusions: SFA has been demonstrated as an accurate, available and cheap method for determination of FFM and FM with application of the Durnin Womersley equation for body density and with the Siri equation for FM in patients with COPD. SFA can be easily applied in routine clinical practice.

Hronek M; Kovarik M; Aimova P; Koblizek V; Pavlikova L; Salajka F; Zadak Z

2013-10-01

355

Proposed amendments to the Bankruptcy and Insolvency Act and Companies` Creditors Arrangement Act; CD-ROM ed.  

Energy Technology Data Exchange (ETDEWEB)

The proposed amendments to the Bankruptcy and Insolvency Act (BIA) and the Companies` Creditors Arrangement Act (CCAA), which would have a significant impact on creditors` rights and remedies when dealing with a petroleum industry insolvency, were explained. An explanation was presented for the structured procedures that should be followed for: (1) Directors` liability, (2) Protection given to trustees and receivers against pre-appointment corporate obligations, and (3) International insolvencies.

Robinson, L.B.

1996-04-01

356

Proposed amendments to the Bankruptcy and Insolvency Act and Companies' Creditors Arrangement Act  

International Nuclear Information System (INIS)

The proposed amendments to the Bankruptcy and Insolvency Act (BIA) and the Companies' Creditors Arrangement Act (CCAA), which would have a significant impact on creditors' rights and remedies when dealing with a petroleum industry insolvency, were explained. An explanation was presented for the structured procedures that should be followed for: (1) Directors' liability, (2) Protection given to trustees and receivers against pre-appointment corporate obligations, and (3) International insolvencies.

1996-01-01

357

Recent Electrochemical and Optical Sensors in Flow-Based Analysis  

Directory of Open Access Journals (Sweden)

Full Text Available Some recent analytical sensors based on electrochemical and optical detectioncoupled with different flow techniques have been chosen in this overview. A briefdescription of fundamental concepts and applications of each flow technique, such as flowinjection analysis (FIA), sequential injection analysis (SIA), all injection analysis (AIA),batch injection analysis (BIA), multicommutated FIA (MCFIA), multisyringe FIA(MSFIA), and multipumped FIA (MPFIA) were reviewed.

Orawon Chailapakul; Passapol Ngamukot; Alongkorn Yoosamran; Weena Siangproh; Nattakarn Wangfuengkanagul

2006-01-01

358

Comparison of the validity of anthropometric and bioelectric impedance equations to assess body composition in adolescent girls.  

UK PubMed Central (United Kingdom)

OBJECTIVE: The purpose of this study was to examine the validity of two anthropometric and four bioelectric impedance (BIA) equations to estimate body composition from dual-energy x-ray absorptiometry (DXA) in adolescent girls of various ethnicities. The rationale for this study was to develop a prediction equation for percent body fat in a multi-ethnic, representative sample of sixth to eighth grade girls. DESIGN: One-hundred and sixty-six girls (51 African-American, 45 non-Black Hispanic, 55 non-Hispanic Caucasian, 15 multi-ethnic) participated. Estimates of percent fat and fat-free mass (FFM) from six published BIA and anthropometric equations and the equation developed from this study were compared to body composition determined from DXA. An RJL Systems analyzer was used to measure BIA. Anthropometry included body weight, height, and triceps and calf skinfolds. RESULTS: Average (± SD) age, size and body composition was as follows: age, 12.1±1.2 yrs, body mass 52.7±15.9 kg, height, 154.6±8.1 cm; DXA percent fat, 27.9±10.4; fat mass (FM), 15.6±10.2 kg; and fat free mass (FFM) 35.7±6.8 kg. No ethnic differences were found in the relationships between estimated and DXA measured body composition, with the exception of the skinfold equation. The six equations explained on average 82% of the variance in percent fat, 94% of the variance in fat mass, and 88% in fat free mass. Bland-Altman analysis indicated that none of the equations performed satisfactorily in our sample. CONCLUSIONS: The BIA and anthropometric equations were significantly related to DXA body composition parameters, however none met the criteria for cross-validation.

Loftin M; Nichols J; Going S; Sothern M; Schmitz KH; Ring K; Tuuri G; Stevens J

2007-01-01

359

Body adiposity index (BAI) correlates with BMI and body fat pre- and post-bariatric surgery but is not an adequate substitute for BMI in severely obese women.  

UK PubMed Central (United Kingdom)

OBJECTIVE: Body Adiposity Index (BAI), a new surrogate measure of body fat (hip circumference/[height 1.5-18]), has been proposed as a more accurate alternative to BMI. We compared BAI with BMI and their correlations with measures of body fat, waist circumference (WC), and indirect indices of fat pre- and post-Roux-en-Y gastric bypass (RYGB). METHODS: Sixteen clinically severe obese (CSO) non-diabetic women (age = 33.9± 7.9 SD; BMI = 46.5±9.5 kg/m(2)) were assessed pre-surgery, and at 2 (n=9) and 5 mo (n=8) post-surgery. Body fat percentage (% fat) was estimated with bioimpedance analysis (BIA), air displacement plethysmography (ADP), and dual-energy x-ray absorptiometry (DXA). WC, an indicator of central fat, and both plasma leptin (ng/ml) and insulin (mU/l) concentrations were measured as indirect body fat indices. Pre- and post-surgery values were analyzed with Pearson correlations and linear regressions. RESULTS: BAI and BMI correlated significantly with each other pre-surgery and at each time point post surgery. BAI and BMI also correlated significantly with % fat from BIA and ADP; however, only BMI correlated significantly with % fat from DXA pre- and post-RYGB. BMI was the single best predictor of WC and leptin at 2 and 5 mo post-surgery and had significant longitudinal changes correlating with % fat from BIA and DXA as well as with leptin. DISCUSSION: Both BAI and BMI were good surrogates of % fat as estimated from BIA and ADP, but only BMI was a good surrogate of % fat from DXA in CSO women. Thus, BAI may not be a better alternative to BMI.

Gibson CD; Atalayer D; Flancbaum L; Geliebter A

2012-01-01

360

Body composition and body fat distribution in relation to later risk of acute myocardial infarction: a Danish follow-up study  

DEFF Research Database (Denmark)

Introduction:Obesity is a modifiable risk factor for acute myocardial infarction (MI), but lean body mass (LBM) may also be an important factor. Low LBM may increase the risk of MI and LBM may modify the effect of obesity on MI. Thus, the inability of the classical anthropometric measures to evaluate LBM may lead to misclassification of MI risk in both lean and obese persons. We investigated the associations between incident MI and bioelectrical impedance analyses (BIA) derived measures of body composition in combination with body mass index (BMI) and anthropometric measures of body fat distribution.Methods and results:From 1993 to 1997, 27¿148 men and 29¿863 women, aged 50 to 64 year, were recruited into the Danish prospective study Diet, Cancer and Health. During 11.9 years of follow-up we identified 2028 cases of incident MI (1487 men and 541 women). BMI, waist circumference (WC), hip circumference and BIA of body composition including body fat mass (BFM), body fat percentage and LBM were measured at baseline. We used Cox proportional hazard models with age as time axis and performed extensive control for confounding. Weight, BMI, classical estimates of abdominal obesity and BIA estimates of obesity showed significant positive associations with incident MI. However, BFM adjusted for WC showed no association. Low LBM was associated with a higher risk of incident MI in both genders, and high LBM was associated with a higher risk in men.Conclusion:Obesity was positively associated with MI. Estimates of obesity achieved by BIA seemed not to add additional information to classical anthropometric measures regarding MI risk. Both high and low LBM may be positively associated with MI.International Journal of Obesity advance online publication, 1 February 2011; doi:10.1038/ijo.2010.278.

Stegger, Jakob; Schmidt, E B

2011-01-01

 
 
 
 
361

Method for the determination of burning and explosion characteristics of dust  

Energy Technology Data Exchange (ETDEWEB)

For the assessment of potential dust explosion risks as well as for the selection and dimensioning of protective measures against explosions, information on burning and explosion characteristics of materials to be processed are required. The Berufsgenossenschaftliches Institut fuer Arbeitssicherheit - BIA applies different test methods for the determination of burning and explosion characteristics. The paper describes the characteristics, the test procedures and the methodology on which the tests are based. (orig.).

Beck, H.; Glienke, N.

1985-11-01

362

Criteria equivalent to the Riemann Hypothesis  

CERN Multimedia

We give a brief overview of a few criteria equivalent to the Riemann Hypothesis. Next we concentrate on the Riesz and B{\\'a}ez-Duarte criteria. We proof that they are equivalent and we provide some computer data to support them. It is not compressed to six pages version of the talk delivered by M.W. during the XXVII Workshop on Geometrical Methods in Physics, 28 June -- 6 July, 2008, Bia{\\l}owie{\\.z}a, Poland.

Cislo, J

2008-01-01

363

DXA, bioelectrical impedance, ultrasonography and biometry for the estimation of fat and lean mass in cats during weight loss  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Few equations have been developed in veterinary medicine compared to human medicine to predict body composition. The present study was done to evaluate the influence of weight loss on biometry (BIO), bioimpedance analysis (BIA) and ultrasonography (US) in cats, proposing equations to estimate fat (FM) and lean (LM) body mass, as compared to dual energy x-ray absorptiometry (DXA) as the referenced method. For this were used 16 gonadectomized obese cats (8 males and 8 females) in a weight loss program. DXA, BIO, BIA and US were performed in the obese state (T0; obese animals), after 10% of weight loss (T1) and after 20% of weight loss (T2). Stepwise regression was used to analyze the relationship between the dependent variables (FM, LM) determined by DXA and the independent variables obtained by BIO, BIA and US. The better models chosen were evaluated by a simple regression analysis and means predicted vs. determined by DXA were compared to verify the accuracy of the equations. Results The independent variables determined by BIO, BIA and US that best correlated (p?r2, 19 equations were selected (12 for FM, 7 for LM); however, only 7 equations accurately predicted FM and one LM of cats. Conclusions The equations with two variables are better to use because they are effective and will be an alternative method to estimate body composition in the clinical routine. For estimated lean mass the equations using body weight associated with biometrics measures can be proposed. For estimated fat mass the equations using body weight associated with bioimpedance analysis can be proposed.

Borges Naida C; Vasconcellos Ricardo S; Carciofi Aulus C; Gonçalves Karina N V; Paula Francisco J A; Filho Daniel E; Canola Júlio C

2012-01-01

364

Solution of electric power system problems using nonlinear programming methods; Resolucao de problemas de sistemas eletricos de potencia usando metodos de programacao nao linear  

Energy Technology Data Exchange (ETDEWEB)

In this literature, three nonlinear optimization methodologies are studied: the Lagrangian Function Method, the Penalty Function Method. Through the studies of the Langrangian Function and the Penalty Function Method, it was possible to reach the formulation of the Augmented Lagrangian Function aiming to solve nonlinear nonconvex programming problems. Numerical tests are presented for the nonconvex programming problem known as optimal power flow. (author) 6 refs., 3 figs., 3 tabs.; e-mail: bia at sel.eesc.sc.usp.br

Nascimentos, Clebea Araujo; Costa, Geraldo R.M. da [Sao Paulo Univ., Sao Carlos, SP (Brazil). Dept. de Engenharia Eletrica

1997-12-31

365

Is a single bioelectrical impedance equation valid for children of wide ranges of age, pubertal status and nutritional status? Evidence from the 4-component model.  

UK PubMed Central (United Kingdom)

BACKGROUND/OBJECTIVES: Bioelectrical impedance analysis (BIA) is widely used to predict body composition in paediatric research and clinical practice. Many equations have been published, but provide inconsistent predictions. AIMS: To test whether a single equation for lean mass (LM) estimation from BIA is appropriate across wide ranges of age, pubertal status and nutritional status, by testing whether specific groups differ in the slope or intercept of the equation. SUBJECTS/METHODS: In 547 healthy individuals aged 4-24 years (240 males), we collected data on body mass (BM) and height (HT), and lean mass (LM) using the 4-component model. Impedance (Z) was measured using TANITA BC418MA instrumentation. LM was regressed on HT(2)/Z. Multiple regression analysis was conducted to investigate whether groups based on gender, age, pubertal status or nutritional status differed in the association of LM with HT(2)/Z. RESULTS: BM ranged from 5 to 128 kg. HT(2)/Z was a strong predictor of LM (r (2)=0.953, s.e.e.=2.9 kg). There was little evidence of a sex difference in this relationship, however, children aged 4-7 years and 16-19 years differed significantly from other age groups in regression slopes and intercepts. Similar variability was encountered for pubertal stage, but not for nutritional status. CONCLUSIONS: No single BIA equation applies across the age range 4-24 years. At certain ages or pubertal stages, the slope and intercept of the equation relating LM to HT(2)/Z alters. Failure to address such age effects is likely to result in poor accuracy of BIA (errors of several kg) for longitudinal studies of change in body composition.

Montagnese C; Williams JE; Haroun D; Siervo M; Fewtrell MS; Wells JC

2013-01-01

366

Comparison of DEXA-derived body fat measurement to two race-specific bioelectrical impedance equations in healthy Indians.  

UK PubMed Central (United Kingdom)

AIM: Prevalence of obesity is increasing in Asian Indians. Reliable, precise and convenient methods to estimate body composition are required. This study aimed to test the accuracy of bioelectrical impedance analysis (BIA) estimates of body composition among Asian Indians according to two BIA equations--one developed for Asians, the other for Caucasians. METHODS: Two hundred apparently healthy Asian Indians (100 males, 100 females; mean age 36.6 ± 7.6 years; mean BMI 16.6-46.7 kg/m(2)) underwent BIA assessment of fat mass (FM), fat free mass (FFM) and percentage body fat (%BF) using Tanita Multi-Frequency Body Composition Analyzer MC-180MA (Tanita Corporation, Tokyo, Japan). One set of BIA values was automatically calculated by the analyzer (Caucasian figures), the other set by Tanita (Japanese Asian figures). Results were compared to dual X-ray absorptiometry (DEXA) as the standard measure. RESULTS: A moderate level of relative agreement was found between the DEXA-derived measurement of %BF and the estimate from both the Caucasian (r(2)=0.75; p<0.001) and Asian equation (r(2)=0.7; p<0.001). Despite this, the level of absolute agreement was poor, with large bias and wide limits of agreement. According to the Caucasian equation the mean difference between methods was -8.3 ± 3.9 (95% limits of agreement -20.10 to 9.40), for the Asian equations mean difference was -5.4 ± 4.3 (95% limits of agreement -20.63 to 11.41). INTERPRETATION AND CONCLUSIONS: When compared to DEXA, the current Asian and Caucasian Tanita formulae significantly under-estimate the %BF of Asian Indians.

Nigam P; Misra A; Colles SL

2013-04-01

367

Anthropometric methods for obesity screening in schoolchildren: the Ouro Preto Study.  

UK PubMed Central (United Kingdom)

BACKGROUND AND AIMS: Childhood obesity is increasing dramatically in last decades. To evaluate the usefulness of body mass index (BMI), skinfold thickness (ST), waist circumference (WC), and foot-to-foot bioelectrical impedance (BIA-FF) for screening for obesity in mixed-race population, using the tetrapolar bioelectrical impedance (BIA-T) technique as reference method. METHODS AND RESULTS: A cross-sectional-based population study was performed in the city of Ouro Preto, Brazil, in 2006. Schoolchildren aged 6-15 years (n = 788) was randomly selected according to age and sex stratified by the proportion of students in each schools of the city. Nonparametric receiver operating characteristic (ROC) analysis was used to define the sensitivity and specificity for each method studied using the tetrapolar method as reference. The BMI and the BIA-FF were the most suitable for adiposity screening in pre-pubertal and pubertal stages because they present a better balance between sensitivity and specificity, and smaller misclassification. For post-pubertal boys, the BF-ST-D was the best body fat assessment method. CONCLUSION: The results suggest that BIA-FF and BMI are choice methods for obesity screening in mixed population and that the method choice for body fat screening must be done according to sexual maturity of boys and girls. The present study demonstrates the need to perform studies in wider mixed-race population to determine anthropometric parameters and to examine the predictive ability of methods and cut-offs here elucidated in the development of obesity.

Cándido AP; Alosta JP; Oliveira CT; Freitas RN; Freitas SN; Machado-Coelho GL

2012-01-01

368

Parasites of carnivorous mammals in Bialowieza Primeval Forest.  

UK PubMed Central (United Kingdom)

BACKGROUND: Although the parasitofauna of wild carnivorous mammals in Poland is quite well recognized, there has been only one research carried on this issue so far in Bia?owieza Forest--the last lowland primeval forest of temperate zone in Europe. MATERIAL AND METHODS: Twelve wild and two domestic species of carnivorous mammals are living in Bia?owieza Forest. In our work faeces or intestines of all of them except ermine (Mustela erminea) have been examined and parasites or their eggs (or oocysts) recorded. In total 222 faecal probes from 13 species and 11 intestines of weasels have been investigated. RESULTS: All species of examined carnivorous mammals were infected with parasites. The most infected species has occurred red fox Vulpes vulpes (over 70% infected with parasites) meanwhile only about 30% of otters Lutra lutra were infected. We found at least three protozoan species, one trematode, one tapeworm and nine species of nematodes. Except trematode Alaria alata, all of them are reported for the first time from Bia?owieza Primeval Forest. Oocysts of coccidia have been found in faeces of nine host species, with the highest prevalence (29.4%) in badger. Six species of carnivorous mammals have been occurred infected with trematodes (highest prevalence 42.1% in wolves) and two with tapeworms (Diphyllobothrium latum with the prevalence 2.6% in otter and 31.6% in wolves). All examined host species were infected with nematodes (with prevalence from 14.7% in lynx to 72.7% in red fox). Results of our work should be treated as preliminary researches on the species composition of parasitic fauna invading carnivorous mammals in Bia?owieza Primeval Forest.

Górski P; Zalewski A; Lakomy M

2006-01-01

369

[Evaluation of nutrition and physical activity of students in Gastronomic School in Bialystok].  

UK PubMed Central (United Kingdom)

The aim of this study was to estimate nutrition and physical activity of students in Gastronomic School in Bia?ystok. Questionnaire about nutrition and physical activity took on April 2008 in 74 students. The content of energy and main nutrition values were calculated and compared to the recommended values. Students diet included normal of energy, protein, fats and carbohydrates. Only 58% girls and 61% boys had intensive physical activity. Change of nutrition and moderate in physical activity is recommended for the students.

Charkiewicz A; Charkiewicz W; Szpak A

2009-01-01

370

On the Blind Interference Alignment over Homogeneous Block Fading Channels  

CERN Multimedia

Staggered fading pattern between different users is crucial to interference alignment without CSIT, or so-called blind interference alignment (BIA). This special fading structure naturally arises from heterogeneous block fading setting, in which different users experience independent block fading with different coherent times. Jafar et al. prove that BIA can be applied in some special heterogeneous block fading channels, which are formed naturally or constructed artificially. In this paper, we show that in the context of a 2-user 2x1 broadcasting (BC) channel, staggered fading pattern can also be found in homogeneous block fading setting, in which both users experience independent fading with the same coherent time; and we propose a scheme to achieve the optimal 4/3 DoF for the homogenous setting by using BIA. Applying the proposed scheme, we further study a 2x1 BC network with K users undergoing homogeneous block fading. When K>=4, we show it is almost guaranteed that the transmitter can find two users among...

Zhou, Qing F

2012-01-01

371

Multiparametric Body Composition Analysis and Anthropometric Empirical Indicator: Obesity based South Indian Perspective.  

UK PubMed Central (United Kingdom)

Background: Obesity has emerged to be global threat to mankind. Many abnormalities such as Cardiovascular Diseases, Diabetes emerge as outcomes of obesity. Objectives: The present study aimed at bringing out a technique, which considers the combinational measurement of all essential anthropometric circumferences and BMI, so that the accurate assessment of obesity can be made. Till date, BMI has been considered to be the main adiposity index. But, the distribution of body fat was not taken into account by BMI. The contradictory outcomes by BMI pertaining to risk factor detection in various ethnicities and populations were witnessed. Also, BMI failed to gauge obesity in muscular body builders who possess small waists and large torsos Materials and Methods: The study adopted cross-sectional design in which 107 subjects from urban south India were participated. The measurements of body composition and anthropometry were manifested on the studied population. Results: The higher significant difference of ?0.001 was witnessed in male and female studied population, when AEI (BIA1), AEI (EXTERNAL) and BMI were compared against BFM (measured by both the devices BIA1 and BIA2). Conclusion: The results exhibited the prominence of AEI {Anthropometric Empirical Indicator, which is the combinational measurement of all essential anthropometric circumferences and BMI} over BMI.Also,the validity of the effective functioning of low cost,portable,simple protocol based body composition analyzer on par with the higher cost, standard body composition analyzer was demonstrated by the present study.

Kishore MK; Anburajan M

2013-04-01

372

Age and sex influence the relationship between waist circumference and abdominal fat distribution measured by bioelectrical impedance.  

UK PubMed Central (United Kingdom)

Waist circumference (WC) is a subrogate measurement of abdominal visceral fat (AVF) with a different normal threshold for men and women. However, age plays an important role in the relationship of WC with AVF. The hypothesis of the present work was that the adjustment of the WC, not only by sex but also by age, would improve WC prediction of AVF as measured by a new bioelectrical impedance (BIA) methodology. The study was carried out in 311 subjects (178 men and 133 women) with a body mass index between 18 and 35 kg/m(2). Abdominal fat composition was measured by BIA by using a new device recently developed specifically for the measurement of abdominal fat compartments (ViScan AB140;Omron Corp, Tokyo, Japan). Clinical, anthropometric, and biochemical data were also collected. There was a high correlation of WC with total abdominal fat and AVF in all age ranges and for both fat depots, which decreased with age in men but remained more stable in women. Age independently influenced the level of AVF in women and in those subjects with normal WC, increasing by 0.32 and 0.47 for each decade of age, respectively. In conclusion, age plays an important role in the association between WC and AVF with a high correlation existing in all age ranges. A specific BIA method that measures abdominal composition would be useful in women and in those subjects with normal WC as an indicator of AVF.

Mateo-Gallego R; Bea AM; Jarauta E; Perez-Ruiz MR; Civeira F

2012-06-01

373

Multiparametric Body Composition Analysis and Anthropometric Empirical Indicator: Obesity based South Indian Perspective.  

Science.gov (United States)

Background: Obesity has emerged to be global threat to mankind. Many abnormalities such as Cardiovascular Diseases, Diabetes emerge as outcomes of obesity. Objectives: The present study aimed at bringing out a technique, which considers the combinational measurement of all essential anthropometric circumferences and BMI, so that the accurate assessment of obesity can be made. Till date, BMI has been considered to be the main adiposity index. But, the distribution of body fat was not taken into account by BMI. The contradictory outcomes by BMI pertaining to risk factor detection in various ethnicities and populations were witnessed. Also, BMI failed to gauge obesity in muscular body builders who possess small waists and large torsos Materials and Methods: The study adopted cross-sectional design in which 107 subjects from urban south India were participated. The measurements of body composition and anthropometry were manifested on the studied population. Results: The higher significant difference of ?0.001 was witnessed in male and female studied population, when AEI (BIA1), AEI (EXTERNAL) and BMI were compared against BFM (measured by both the devices BIA1 and BIA2). Conclusion: The results exhibited the prominence of AEI {Anthropometric Empirical Indicator, which is the combinational measurement of all essential anthropometric circumferences and BMI} over BMI.Also,the validity of the effective functioning of low cost,portable,simple protocol based body composition analyzer on par with the higher cost, standard body composition analyzer was demonstrated by the present study. PMID:23558309

Kishore, Mohan K B; Anburajan, M

2013-04-01

374

Comparison of two bioelectrical impedance analysis devices with dual energy X-ray absorptiometry and magnetic resonance imaging in the estimation of body composition.  

Science.gov (United States)

We compared a 4-limb bioelectrical impedance analysis (BIA) system, HBF 359 (Omron), and a 2-limb foot-to-foot device, BC 532 (Tanita), with the standard dual energy X-ray absorptiometry (DXA) and magnetic resonance imaging (MRI) methods for the measurement of body fat percentage (BF), skeletal muscle mass percentage (SMM, or fat-free mass [FFM] for BC 532), and visceral fat level (VF). Body composition was measured in 200 healthy volunteers (100 men and 100 women, mean age 48 years) by HBF 359 and BC 532 and by DXA and MRI. The agreement was assessed by correlation analysis and paired t-test. The correlation coefficients between BIA and DXA or MRI ranged from 0.71 to 0.89 for BF, SMM, and VF by HBF 359 and from 0.77 to 0.90 for BF, FFM, and VF by BC 532 in all subjects and in men and women separately (p SMM, and +13.3% (p < 0.001) and -8.5% (p = 0.006), for VF. The corresponding values by BC 532 in men and women were -10.7 and -6.2% for BF, -1.4 and -2.5% for FFM, and +20.4 and -18.0% for VF. The BIA devices are accurate in the estimation of body composition, especially skeletal muscle mass or FFM. PMID:22344056

Wang, Ji-Guang; Zhang, Yi; Chen, Han-E; Li, Yan; Cheng, Xiao-Guang; Xu, Li; Guo, Zhe; Zhao, Xing-Shan; Sato, Tetsuya; Cao, Qi-Yun; Chen, Ke-Min; Li, Biao

2013-01-01

375

Southpoint power plant final environmental impact statement  

International Nuclear Information System (INIS)

This document is the Final Environmental Impact Statement (FEIS) for a proposed lease of acreage on the Fort Mojave Indian Reservation in Mohave County, Arizona for development of a natural gas fired 500 megawatt combined cycle power plant. The Bureau of Indian Affairs (BIA) serves as the federal lead agency and the Fort Mojave Indian Tribe (FMIT) and the Western Area Power Administration (WAPA) are cooperating agencies for the EIS process. The purpose of this document is to provide information to the public and to interested public agencies regarding the environmental consequences of the approval of a long-term lease for the construction and operation of the proposed Southpoint power plant. The FEIS, prepared by Hallock/Gross, Inc. under the direction of the BIA and in cooperation with the FMIT and WAPA, addresses the comparative analysis of alternatives and evaluates the environmental consequences of such alternatives on various resources and addresses public comments. A number of technical reports were used in the preparation of the Draft EIS and FEIS and are available for review as Appendices to this document under separate cover that can be reviewed at the BIA offices which are listed

1999-01-01

376

Bulk Inversion Asymmetry effects on the band structure of zincblende heterostructures in an 8-band Effective Mass Approximation model  

CERN Multimedia

We have developed an 8-band Effective Mass Approximation model that describes the zero field spin splitting in the band structure of zincblende heterostructures due to bulk inversion asymmetry (BIA). We have verified that our finite difference Hamiltonian transforms in almost all situations according to the true $D_{2d}$ or $C_{2v}$ symmetry of [001] heterostructures. This makes it a computationally efficient tool for the accurate description of the band structure of heterostructures for spintronics. We first compute the band structure for an AlSb/GaSb/AlSb quantum well (QW), which presents only BIA, and delineate its effects. We then use our model to find the band structure of an AlSb/InAs/GaSb/AlSb QW and the relative contribution of structural and bulk inversion asymmetry to the spin splitting. We clarify statements about the importance of these contributions and conclude that, even for our small gap QW, BIA needs to be taken into account for the proper description of the band structure.

Cartoixa, X; McGill, T C

2002-01-01

377

Concordancia entre los porcentajes de grasa corporal estimados mediante el área adiposa del brazo, el pliegue del tríceps y por impedanciometría brazo-brazo/ Interchangeability among the Percentages of Body Fat Estimated by Mid-Arm Adipose Area, Triceps Skinfold Thickness and Arm-to-Arm Segmental Bioimpedance Analysis  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Fundamento: La valoración del estado nutricional a partir de los miembros superiores es útil a nivel clínico. El objetivo de este trabajo es analizar el grado de acuerdo entre los porcentajes de grasa corporal (%GC) estimados mediante el área adiposa del brazo (%GC BRAZO), la ecuación de Siri para el pliegue del tríceps (%GC TRÍCEPS) y por bioimpedanciometría brazo-brazo (%GC BIA), así como con la ecuación de Siri para cuatro pliegues (%GC SIRI). Métodos: Estud (more) io descriptivo transversal. Se valoró antropométricamente y por impedanciometría (Omron BF 300©) a 145 personas (83 varones, 62 mujeres). La concordancia entre métodos se analizó mediante el coeficiente de correlación intraclase (CCI) y el método de Bland-Altman. Resultados: el CCI entre %GC BRAZO-%GC TRÍCEPS fue de 0,8322 (intervalo de confianza al 95% 0,7672-0,8791); entre %GCB RAZO-%GC BIA de 0,7337 (0,6305-0,8080) y entre %GC TRICEPS-%GC BIA de 0,9290 (0,9015; 0,9488). Con el método de Bland-Altman el intervalo de concordancia entre %GC BRAZO-%GC TRÍCEPS (-11,2; 16,96) y entre %GC BRAZO-%GC BIA (-13,04; 21,76) superó el punto de corte (±10%), pero no entre %G CTRICEPS-%GC BIA (-6,64; 9,6), %GC SIRI-%GC TRÍCEPS (-5,27; 4,52) y %GC SIRI-%GC BIA (-6,31; 8,52). El IMC no influyó en el resultado. Conclusiones: El método utilizado influye en la valoración nutricional realizada a partir de los miembros superiores. El área adiposa del brazo sobreestima el %GC con relación a la ecuación de Siri para el pliegue del tríceps o para cuatro pliegues y a la impedanciometría, y aunque este resultado sugiere que el área adiposa del brazo puede no ser un ind