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Sample records for system mps development

  1. Space Station Mission Planning System (MPS) development study. Volume 1: Executive summary

    Klus, W. J.

    1987-01-01

    The basic objective of the Space Station (SS) Mission Planning System (MPS) Development Study was to define a baseline Space Station mission plan and the associated hardware and software requirements for the system. A detailed definition of the Spacelab (SL) payload mission planning process and SL Mission Integration Planning System (MIPS) software was derived. A baseline concept was developed for performing SS manned base payload mission planning, and it was consistent with current Space Station design/operations concepts and philosophies. The SS MPS software requirements were defined. Also, requirements for new software include candidate programs for the application of artificial intelligence techniques to capture and make more effective use of mission planning expertise. A SS MPS Software Development Plan was developed which phases efforts for the development software to implement the SS mission planning concept.

  2. MPS II drift chamber system

    The MPS II detectors are narrow drift space chambers designed for high position resolution in a magnetic field and in a very high particle flux environment. Central to this implementation was the development of 3 multi-channel custom IC's and one multi-channel hybrid. The system is deadtimeless and requires no corrections on an anode-to-anode basis. Operational experience and relevance to ISABELLE detectors is discussed

  3. Space Station Mission Planning System (MPS) development study. Volume 2

    Klus, W. J.

    1987-01-01

    The process and existing software used for Spacelab payload mission planning were studied. A complete baseline definition of the Spacelab payload mission planning process was established, along with a definition of existing software capabilities for potential extrapolation to the Space Station. This information was used as a basis for defining system requirements to support Space Station mission planning. The Space Station mission planning concept was reviewed for the purpose of identifying areas where artificial intelligence concepts might offer substantially improved capability. Three specific artificial intelligence concepts were to be investigated for applicability: natural language interfaces; expert systems; and automatic programming. The advantages and disadvantages of interfacing an artificial intelligence language with existing FORTRAN programs or of converting totally to a new programming language were identified.

  4. MPS Data Acquisition System

    A description is given of the data acquisition system used with the multiparticle spectrometer facility at Brookhaven. Detailed information is provided on that part of the system which connects the detectors to the data handler; namely, the detector electronics, device controller, and device port optical isolator

  5. The APS machine protection system (MPS)

    The machine protection system (MPS) that protects the APS storage ring vacuum chamber from x-ray beams, is active. There are over 650 sensors monitored and networked through the MPS system. About the same number of other process variables are monitored by the much slower EPICS control system, which also has an input to the rf abort chain. The MPS network is still growing with the beam position limits detection system coming on-line. The network configuration, along with a limited description of individual subsystems, is presented

  6. The APS machine protection system (MPS)

    The machine protection system (MPS) that protects the APS storage ring vacuum chamber from x-ray beams, is active. There are over 650 sensors monitored and networked through the MPS system. About the same number of other process variables are monitored by the much slower EPICS control system, which also has an input to the rf abort chain. The MPS network is still growing with the beam position limits detection system coming on-line. The network configuration, along with a limited description of individual subsystems, is presented. copyright 1997 American Institute of Physics

  7. Development of J-PARC LINAC/RCS MPS sub system

    To decrease the heat damage and the radiation damage because of the beam collision extremely, MPS of J-PARC was set up. Actually, high speed (All processes from the beam loss detection to the beam complete stop around 5μ second: measurement) that almost meets a first specification and high reliability (The malfunction rate not to understand the cause is almost 0%) have been achieved though it becomes 1 and a half years by being operated in J-PARC Linac. However, it is understood that there is a demand that should be satisfied because the beam is stopped at high speed when an actual beam driving as facilities for research is considered. Then, we produced 'Logic controller', 'MWPM unit', 'Pulse pipe bend unit', and 'Trigger the checker' to satisfy these demands, and mounted it. (author)

  8. Space Station Mission Planning Study (MPS) development study. Volume 3: Software development plan

    Klus, W. L.

    1987-01-01

    A software development plan is presented for the definition, design, and implementation of the Space Station (SS) Payload Mission Planning System (MPS). This plan is an evolving document and must be updated periodically as the SS design and operations concepts as well as the SS MPS concept evolve. The major segments of this plan are as follows: an overview of the SS MPS and a description of its required capabilities including the computer programs identified as configurable items with an explanation of the place and function of each within the system; an overview of the project plan and a detailed description of each development project activity breaking each into lower level tasks where applicable; identification of the resources required and recommendations for the manner in which they should be utilized including recommended schedules and estimated manpower requirements; and a description of the practices, standards, and techniques recommended for the SS MPS Software (SW) development.

  9. MPS [Multiparticle Spectrometer] data acquisition software system

    A description of the software for a FASTBUS based data acquisition system in use at the Brookhaven National Laboratory Multiparticle Spectrometer is presented. Data reading and formatting is done by the SLAC Scanner Processors (SSP's) resident in the FASTBUS system. A multiprocess software system on VAX computers is used to communicate with the SSP's, record the data, and monitor on-line the progress of high energy and heavy ion experiments. The structure and the performance of this system are discussed. 4 refs., 1 fig

  10. 3D simulation of eutectic interaction of Pb–Sn system using Moving Particle Semi-implicit (MPS) method

    Highlights: • Development of MPS eutectic model for solid–solid interaction. • Analysis of experiments dealing with eutectic behavior of Pb–Sn by MPS simulation. • The analysis has revealed the mechanism of eutectic melting due to eutectic reaction. - Abstract: The eutectic reaction phenomenon was analyzed based on the Moving Particle Semi-implicit (MPS) method. The improved MPS code was applied to three-dimensional Pb–Sn system experiments conducted at Central Research Institute of Electric Power Industry (CRIEPI). The experiments dealt with solid–solid contact materials at 225 and 205 °C. The mass diffusion process was modeled based on Fick’s second law. The criterion of eutectic reaction was modeled based on binary phase diagram. The calculated penetration rates, i.e. height reduction rates, were compared with the experimental measurements. The results obtained by the MPS simulations exhibit good agreement with the experiments carried out at 205 and 225 °C. MPS simulation predicted that Sn particle will liquefy earlier than Pb particle

  11. Neonatal Systemic AAV Induces Tolerance to CNS Gene Therapy in MPS I Dogs and Nonhuman Primates.

    Hinderer, Christian; Bell, Peter; Louboutin, Jean-Pierre; Zhu, Yanqing; Yu, Hongwei; Lin, Gloria; Choa, Ruth; Gurda, Brittney L; Bagel, Jessica; O'Donnell, Patricia; Sikora, Tracey; Ruane, Therese; Wang, Ping; Tarantal, Alice F; Casal, Margret L; Haskins, Mark E; Wilson, James M

    2015-08-01

    The potential host immune response to a nonself protein poses a fundamental challenge for gene therapies targeting recessive diseases. We demonstrate in both dogs and nonhuman primates that liver-directed gene transfer using an adeno-associated virus (AAV) vector in neonates induces a persistent state of immunological tolerance to the transgene product, substantially improving the efficacy of subsequent vector administration targeting the central nervous system (CNS). We applied this approach to a canine model of mucopolysaccharidosis type I (MPS I), a progressive neuropathic lysosomal storage disease caused by deficient activity of the enzyme α-l-iduronidase (IDUA). MPS I dogs treated systemically in the first week of life with a vector expressing canine IDUA did not develop antibodies against the enzyme and exhibited robust expression in the CNS upon intrathecal AAV delivery at 1 month of age, resulting in complete correction of brain storage lesions. Newborn rhesus monkeys treated systemically with AAV vector expressing human IDUA developed tolerance to the transgene, resulting in high cerebrospinal fluid (CSF) IDUA expression and no antibody induction after subsequent CNS gene therapy. These findings suggest that inducing tolerance to the transgene product during a critical period in immunological development can improve the efficacy and safety of gene therapy. PMID:26022732

  12. DET/MPS - THE GSFC ENERGY BALANCE PROGRAM, DIRECT ENERGY TRANSFER/MULTIMISSION SPACECRAFT MODULAR POWER SYSTEM (UNIX VERSION)

    Jagielski, J. M.

    1994-01-01

    The DET/MPS programs model and simulate the Direct Energy Transfer and Multimission Spacecraft Modular Power System in order to aid both in design and in analysis of orbital energy balance. Typically, the DET power system has the solar array directly to the spacecraft bus, and the central building block of MPS is the Standard Power Regulator Unit. DET/MPS allows a minute-by-minute simulation of the power system's performance as it responds to various orbital parameters, focusing its output on solar array output and battery characteristics. While this package is limited in terms of orbital mechanics, it is sufficient to calculate eclipse and solar array data for circular or non-circular orbits. DET/MPS can be adjusted to run one or sequential orbits up to about one week, simulated time. These programs have been used on a variety of Goddard Space Flight Center spacecraft projects. DET/MPS is written in FORTRAN 77 with some VAX-type extensions. Any FORTRAN 77 compiler that includes VAX extensions should be able to compile and run the program with little or no modifications. The compiler must at least support free-form (or tab-delineated) source format and 'do do-while end-do' control structures. DET/MPS is available for three platforms: GSC-13374, for DEC VAX series computers running VMS, is available in DEC VAX Backup format on a 9-track 1600 BPI tape (standard distribution) or TK50 tape cartridge; GSC-13443, for UNIX-based computers, is available on a .25 inch streaming magnetic tape cartridge in UNIX tar format; and GSC-13444, for Macintosh computers running AU/X with either the NKR FORTRAN or AbSoft MacFORTRAN II compilers, is available on a 3.5 inch 800K Macintosh format diskette. Source code and test data are supplied. The UNIX version of DET requires 90K of main memory for execution. DET/MPS was developed in 1990. A/UX and Macintosh are registered trademarks of Apple Computer, Inc. VMS, DEC VAX and TK50 are trademarks of Digital Equipment Corporation. UNIX is a registered trademark of AT&T Bell Laboratories.

  13. Marrow stromal cells from patients affected by MPS I differentially support haematopoietic progenitor cell development.

    Baxter, M A; Wynn, R F; Schyma, L; Holmes, D K; Wraith, J E; Fairbairn, L J; Bellantuono, I

    2005-01-01

    Bone marrow transplantation is the therapy of choice in patients affected by MPS I (Hurler syndrome), but a high incidence of rejection limits the success of this treatment. The deficiency of alpha-L-iduronidase (EC 1.2.3.76), one of the enzymes responsible for the degradation of glycosaminoglycans, results in accumulation of heparan and dermatan sulphate in these patients. Heparan sulphate and dermatan sulphate are known to be important components of the bone marrow microenvironment and critical for haematopoietic cell development. In this study we compared the ability of marrow stromal cells from MPS I patients and healthy donors to support normal haematopoiesis in Dexter-type long term culture. We found an inverse stroma/supernatant ratio in the number of clonogenic progenitors, particularly the colony-forming unit granulocyte-machrophage in MPS I cultures when compared to normal controls. No alteration in the adhesion of haematopoietic cells to the stroma of MPS I patients was found, suggesting that the altered distribution in the number of clonogenic progenitors is probably the result of an accelerated process of differentiation and maturation. The use of alpha-L-iduronidase gene-corrected marrow stromal cells re-established normal haematopoiesis in culture, suggesting that correction of the bone marrow microenvironment with competent enzyme prior to transplantation might help establishment of donor haematopoiesis. PMID:16435198

  14. FEDERAL USERS CONFERENCE PRODUCT LINE TOOL SET (PLTS) MAP PRODUCTION SYSTEM (MPS) ATLAS CUSTOM GRIDS [Rev 0 was draft

    Maps, and more importantly Atlases, are assisting the user community in managing a large land area with complex issues, the most complex of which is the management of nuclear waste. The techniques and experiences discussed herein were gained while developing several atlases for use at the US Department of Energy's Hanford Site. The user community requires the ability to locate not only waste sites, but other features as well. Finding a specific waste site on a map and in the field is a difficult task at a site the size of Hanford. To find a specific waste site, the user begins by locating the item or object in an index, then locating the feature on the corresponding map within an atlas. Locating features requires a method for indexing them. The location index and how to place it on a map or atlas is the central theme presented in this article. The user requirements for atlases forced the design team to develop new and innovative solutions for requirements that Product Line Tool Set (PLTS) Map Production System (MPS)-Atlas was not designed to handle. The layout of the most complex atlases includes custom reference grids, multiple data frames, multiple map series, and up to 250 maps. All of these functional requirements are at the extreme edge of the capabilities of PLTS MPS-Atlas. This document outlines the setup of an atlas using PLTS MPS-Atlas to meet these requirements

  15. The characteristics and limitations of the MPS/MMS battery charging system

    Ford, F. E.; Palandati, C. F.; Davis, J. F.; Tasevoli, C. M.

    1980-01-01

    A series of tests was conducted on two 12 ampere hour nickel cadmium batteries under a simulated cycle regime using the multiple voltage versus temperature levels designed into the modular power system (MPS). These tests included: battery recharge as a function of voltage control level; temperature imbalance between two parallel batteries; a shorted or partially shorted cell in one of the two parallel batteries; impedance imbalance of one of the parallel battery circuits; and disabling and enabling one of the batteries from the bus at various charge and discharge states. The results demonstrate that the eight commandable voltage versus temperature levels designed into the MPS provide a very flexible system that not only can accommodate a wide range of normal power system operation, but also provides a high degree of flexibility in responding to abnormal operating conditions.

  16. DET/MPS - THE GSFC ENERGY BALANCE PROGRAM, DIRECT ENERGY TRANSFER/MULTIMISSION SPACECRAFT MODULAR POWER SYSTEM (MACINTOSH A/UX VERSION)

    Jagielski, J. M.

    1994-01-01

    The DET/MPS programs model and simulate the Direct Energy Transfer and Multimission Spacecraft Modular Power System in order to aid both in design and in analysis of orbital energy balance. Typically, the DET power system has the solar array directly to the spacecraft bus, and the central building block of MPS is the Standard Power Regulator Unit. DET/MPS allows a minute-by-minute simulation of the power system's performance as it responds to various orbital parameters, focusing its output on solar array output and battery characteristics. While this package is limited in terms of orbital mechanics, it is sufficient to calculate eclipse and solar array data for circular or non-circular orbits. DET/MPS can be adjusted to run one or sequential orbits up to about one week, simulated time. These programs have been used on a variety of Goddard Space Flight Center spacecraft projects. DET/MPS is written in FORTRAN 77 with some VAX-type extensions. Any FORTRAN 77 compiler that includes VAX extensions should be able to compile and run the program with little or no modifications. The compiler must at least support free-form (or tab-delineated) source format and 'do do-while end-do' control structures. DET/MPS is available for three platforms: GSC-13374, for DEC VAX series computers running VMS, is available in DEC VAX Backup format on a 9-track 1600 BPI tape (standard distribution) or TK50 tape cartridge; GSC-13443, for UNIX-based computers, is available on a .25 inch streaming magnetic tape cartridge in UNIX tar format; and GSC-13444, for Macintosh computers running AU/X with either the NKR FORTRAN or AbSoft MacFORTRAN II compilers, is available on a 3.5 inch 800K Macintosh format diskette. Source code and test data are supplied. The UNIX version of DET requires 90K of main memory for execution. DET/MPS was developed in 1990. A/UX and Macintosh are registered trademarks of Apple Computer, Inc. VMS, DEC VAX and TK50 are trademarks of Digital Equipment Corporation. UNIX is a registered trademark of AT&T Bell Laboratories.

  17. Search for all d-MPs for all d levels in multistate two-terminal networks

    A general method for reliability evaluation of multistate network is using minimal path vectors. A minimal path (MP) vector to system state d is called a d-MP. Most reported works on generating d-MPs are for a particular d value. However, if all d-MPs for all possible integer d values are required, we need to call such methods multiple times with respect to all d values. A more efficient method is desirable to generate all d-MPs. In this paper, we develop a recursive algorithm based on breadth-first search to search for all the d-MPs for all possible d values. The relationships among d-MPs for different d levels are revealed. Each d-MP candidate can be generated by a combination of one (d-1)-MP and the vector form of one binary minimal path. Thus, we can use binary MPs as building blocks to generate 2-MP candidates, and use 2-MPs and binary MPs as building blocks to generate 3-MP candidates … and so forth. When the d-MPs with respect to the maximum d value have been found, all the d-MPs for all possible d values are obtained. A heuristic for pre-processing the MPs is proposed to improve the efficiency of the algorithm. Through computational experiments, it is found that the proposed algorithm is more efficient than existing algorithms for finding all d-MPs for all possible d values. In addition, we show that the proposed algorithm can also be used to generate a subset of d-MPs for all or some d values given a subset of MPs. The generated subset of d-MPs can be used for lower reliability bound evaluation. - Highlights: • The relationships among d-MPs for different d levels are revealed. • An efficient algorithm is developed to search for all d-MPs for all d levels. • A heuristic for pre-processing the MPs is proposed to improve the efficiency. • The computational efficiency of the algorithm is investigated. • A method to search for subsets of d-MPs is proposed for reliability bounding

  18. Can operations put the MPS into an unsafe state?

    Ponce, L

    2011-01-01

    During the 2010 run, the MPS have been additionally stressed by the commissioning of operational procedures and systems tests. As requested by the MPS external review committee, human factors have to be further minimized and discipline reinforced when increasing the stored beam energies towards and beyond the 2010 target of 30 MJ. This talk will present a synthesis of the Evian discussion on MPS and human factors, with an emphasis on the tools and procedures to be put in place for the 2011 run in order to ensure the machine safety during standard beam operation and after periods of machine developments or technical stops.

  19. Multipurpose satellite bus (MPS)

    1991-01-01

    The Naval Postgraduate School Advanced Design Project sponsored by the Universities Space Research Association Advanced Design Program is a multipurpose satellite bus (MPS). The design was initiated from a Statement of Work (SOW) developed by the Defense Advanced Research Projects Agency (DARPA). The SOW called for a 'proposal to design a small, low-cost, lightweight, general purpose spacecraft bus capable of accommodating any of a variety of mission payloads. Typical payloads envisioned include those associated with meteorological, communication, surveillance and tracking, target location, and navigation mission areas.' The design project investigates two dissimilar missions, a meteorological payload and a communications payload, mated with a single spacecraft bus with minimal modifications. The MPS is designed for launch aboard the Pegasus Air Launched Vehicle (ALV) or the Taurus Standard Small Launch Vehicle (SSLV).

  20. Replacement of heavy components of the Main Primary System (MPS). Recent innovations made by Framatome ANP

    The replacement of heavy components is the result of widespread stress corrosion of Inconel 600 (and alloys 82/182) in the primary system. Following the corrosion of steam generator tubes, which led to the first steam generator replacement (SGR) operations, work has begun on reactor vessel head replacements (RVHR) and pressurizer replacements, pending treatment of the dissimilar butt welds (DBW). The replacement of sections of the Main Primary System is one way of optimizing plant lifetime besides preventing stress corrosion in primary components and combating phenomena as thermal fatigue or certain metallurgical weaknesses. The increase in the number of major operations carried out in the reactor building on PWR and BWR reactor geometries has called for major technical innovations. AREVA, has over the past twenty years carried out more than forty SGRs throughout the world, including the supply of 115 steam generators of all types. This equates to over 60% of all SGR operations performed in Europe and the USA. Today, most SGR operations are performed in the USA, though some still continue in Europe and Asia. Operations have been planned until 2015. The first RVHR operations were carried out in France in 1993, and have been widespread in Europe since 1996 (Spain and Belgium), and in the USA since 2002 (Davis Besse). Since 1993 AREVA, through its subsidiaries Framatome ANP, Jeumont SA and SGT, has performed 72 RVHRs, i.e. most of those carried out in Europe and the USA. Today, RVHR operations take place throughout the world and have been planned until 2014. The first pressurizer replacement took place in the fall of 2005 in Saint Lucie, USA. Others are to follow (Fort Calhoun, Millestone). A significant number of partial or complete pressurizer replacements are now being scheduled. Special focus must be given to this new operation, as a decision is required between the following types of replacements, taking into account the number of pressurizer heaters and the condition of the various penetrations (lateral or from above, for instrumentation, unloading, spraying, etc.): - Complete replacement of the component (including dissimilar metal welds, thermal sleeves and even a section of the surge line if necessary); - Bottom replacement; - Replacement of faulty penetrations only. Along with the regular replacement of molded Main Primary System elbows (SGR operations), the following actions have also been carried out: - Replacement of a half crossover leg (SGR-GR4, 2000); - Replacement of a cold leg section (RCLS) with a chemical and volume control system (CVCS) nozzle (SGR-FH1, 2002). In the future we predict work will be carried out on the pressurizer surge line (potentially carried out as part of a pressurizer changeover or as a stand-alone operation). This presentation will focus on the major innovations developed by Framatome ANP, aided by its international customers in order to carry out these primary component replacement operations as well and as quickly as possible. These innovations concern the following domains: - Hoisting and handling; - Metrology and topo-metry; - Machining and welding; - Automated operations in piping; - Operation management. In conclusion one stresses that to increase the lifetime of their nuclear plants, optimize outages and sometimes increase thermal and electrical power it is necessary to optimize the replacement of heavy primary components. To meet the operator needs, suppliers must in turn enhance their capacity and skills in terms of: - Providing near-turnkey services (supplies and work); - Orchestrating these operations (i.e. by performing the duties of an engineering department); - Providing services in a range of fields, from concrete to instrumentation and control, and even performance testing; - Being technically innovative in all of these areas. Since the 1990's, with the assistance of its worldwide customer base, Framatome ANP has been carrying out this approach thanks to its experience as a vendor and manufacturer (OEM), bolstered by the capacities of its Engineering Departments and R and D Centers

  1. Molten uranium eutectic interaction on iron-alloy by MPS method

    Highlights: • Development of MPS development on eutectic model. • Binary phase diagram of Fe–U system development by THERMOCALC with NUCL10 dataset. • Eutectic behavior of TREAT experiment analysis by MPS simulation. - Abstract: Development of moving particle semi-implicit (MPS) method for predicting the eutectic reaction during severe accident, especially at the lower head, in nuclear power plants is important. In this study, solid–liquid system of eutectic interaction was developed. Mass diffusion theory was used for mass transfer between particles. Binary phase diagram was used for developing criteria of transforming into liquid/eutectic particle. THERMOCALC with NUCL10 dataset was utilized to obtain binary phase diagram. Based on the developed MPS model, the TREAT experiments were analyzed. For penetration rates of molten uranium into steel test section, the two-dimensional MPS simulations predicted agreeable values with the experiments for temperature above 1233 and 1187 °C for Armco iron and SS304, respectively. As for SS430, MPS simulation predicted agreeable result at 1244 °C

  2. Space Shuttle Program (SSP) Orbiter Main Propulsion System (MPS) Gaseous Hydrogen (GH2) Flow Control Valve (FCV) Poppet Eddy Current (EC) Inspection Probability of Detection (POD) Study. Volume 2; Appendices

    Piascik, Robert S.; Prosser, William H.

    2011-01-01

    The Director of the NASA Engineering and Safety Center (NESC), requested an independent assessment of the anomalous gaseous hydrogen (GH2) flow incident on the Space Shuttle Program (SSP) Orbiter Vehicle (OV)-105 during the Space Transportation System (STS)-126 mission. The main propulsion system (MPS) engine #2 GH2 flow control valve (FCV) LV-57 transition from low towards high flow position without being commanded. Post-flight examination revealed that the FCV LV-57 poppet had experienced a fatigue failure that liberated a section of the poppet flange. The NESC assessment provided a peer review of the computational fluid dynamics (CFD), stress analysis, and impact testing. A probability of detection (POD) study was requested by the SSP Orbiter Project for the eddy current (EC) nondestructive evaluation (NDE) techniques that were developed to inspect the flight FCV poppets. This report contains the Appendices to the main report.

  3. Space Shuttle Program (SSP) Orbiter Main Propulsion System (MPS) Gaseous Hydrogen (GH2) Flow Control Valve (FCV) Poppet Eddy Current (EC) Inspection Probability of Detection (POD) Study. Volume 1

    Piascik, Robert S.; Prosser, William H.

    2011-01-01

    The Director of the NASA Engineering and Safety Center (NESC), requested an independent assessment of the anomalous gaseous hydrogen (GH2) flow incident on the Space Shuttle Program (SSP) Orbiter Vehicle (OV)-105 during the Space Transportation System (STS)-126 mission. The main propulsion system (MPS) engine #2 GH2 flow control valve (FCV) LV-57 transition from low towards high flow position without being commanded. Post-flight examination revealed that the FCV LV-57 poppet had experienced a fatigue failure that liberated a section of the poppet flange. The NESC assessment provided a peer review of the computational fluid dynamics (CFD), stress analysis, and impact testing. A probability of detection (POD) study was requested by the SSP Orbiter Project for the eddy current (EC) nondestructive evaluation (NDE) techniques that were developed to inspect the flight FCV poppets. This report contains the findings and recommendations from the NESC assessment.

  4. Development of a fluorometric microtiter plate-based enzyme assay for arylsulfatase B (MPS VI using dried blood spots

    Anirudh J. Ullal

    2014-01-01

    Full Text Available Mucopolysaccharidosis type VI or Maroteaux–Lamy syndrome is an autosomal recessive lysosomal storage disorder caused by deficiency of arylsulfatase B (ARS-B enzyme activity. It results in mild to severe multi-organ system failure from accumulation of undigested glycosaminoglycans (GAGs; dermatan sulfate and chondroitin-4-sulfate. We have developed a single-step enzyme assay using a fluorescent substrate and dried blood spots to measure ARS-B activity to identify disease patients. This assay is robust, reproducible, specific and convenient to perform.

  5. OLiMPS. OpenFlow Link-layer MultiPath Switching

    Newman, Harvey B. [California Institute of Technology, Pasadena, CA (United States); Barczyk, Artur [California Institute of Technology, Pasadena, CA (United States); Bredel, Michael [California Institute of Technology, Pasadena, CA (United States)

    2014-11-17

    The OLiMPS project’s goal was the development of an OpenFlow controller application allowing load balancing over multiple switched paths across a complex network topology. The second goal was to integrate the controller with Dynamic Circuit Network systems such as ESnet’s OSCARS. Both goals were achieved successfully, as laid out in this report.

  6. MPS beam control software architecture

    The new Machine Protection System (MPS) now being tested at SLAC has a beam control subsystem resident in processors located close to the beam monitoring devices within the machine. There are two types of beam control micros: Algorithm Processors (AP's) which collect and evaluate data from monitoring devices, and a Supervisor (SUPE) which collects and evaluates data from all the AP's. The SUPE also receives the global machine beamcode indicating beam presence, and passes it on to the AP's. The SUPE receives the beamcode pattern from the Master Pattern Generator (MPG) via a shared-memory communication link. MIL-1553 serial communication is used between the SUPE and the AP's, and between the AP's and the monitoring devices. Multitasking software is used to allow high priority handling of data evaluation and low priority handling of host/user interfacing and event reporting. Pipelining of data between acquisition and evaluation and reporting is used to accommodate the processing capacity, while still supporting full processing at the 36OHz broadcast rate of the beamcode pattern

  7. MPS beam control software architecture

    The new Machine Protection System (MPS) now being tested at SLAC has a beam control subsystem resident in processors located close to the beam monitoring devices within the machine. There are two types of beam control micros: Algorithm Processors (AP's) which collect and evaluate data from monitoring devices, and a Supervisor (SUPE) which collects and evaluates data from all the AP's. The SUPE also receives the global machine beamcode indicating beam presence, and passes it on to the AP's. The SUPE receives the beamcode pattern from the Master Pattern Generator (MPG) via a shared-memory communication link. MIL-1553 serial communication is used between the SUPE and the AP's, and between the AP's and the monitoring devices. Multitasking software is used to allow high priority handling of data evaluation and low priority handling of host/user interfacing and event reporting. Pipelining of data between acquisition and evaluation and reporting is used to accomodate the processing capacity, while still supporting full processing at the 360Hz broadcast rate of the beamcode pattern

  8. Local Government Finance in Ghana: Disbursement and Utilisation of the MPs share of the District Assemblies Common Fund

    Nana Nimo Appiah-Agyekum

    2013-05-01

    Full Text Available The establishment of the District Assembly Common Fund (DACF in 1993 and concomitant percentage set aside for Members of Parliament (MPs in 2004 aims to support local governments and legislators in pro-poor development activities in their communities and constituencies. In spite of the importance of the MPs’ share of the District Assemblies Common Fund (MPsCF in financing local level development in Ghana, very little is known about monitoring systems and procedures on the disbursement and utilization of the funds. The study therefore assessed qualitative data derived from interviews with officials from selected Local Government Authorities (LGAs as well as other key stakeholders in the disbursement and utilization of the fund. The study findings point to the absence of legislative instrument on the management of the MPsCF. Further, monitoring of the fund was a responsibility shared by the LGAs and other external stakeholders. Finally, the effectiveness of monitoring the disbursement and utilization of the MPsCF was strongly influenced by the relationship between the Chief Executive of the Local Government Authority (LGCE and MPs in the local government area.

  9. Microcontroller Programming and Interfacing TI MPS433

    Barrett, Steven

    2011-01-01

    This book provides a thorough introduction to the Texas Instruments MPS430 microcontroller. The MPS430 is a 16-bit reduced instruction set (RISC) processor that features ultra low power consumption and integrated digital and analog hardware. Variants of the MPS430 microcontroller have been in production since 1993. This provides for a host of MPS430 products including evaluation boards, compilers, and documentation. A thorough introduction to the MPS430 line of microcontrollers, programming techniques, and interface concepts are provided along with considerable tutorial information with many i

  10. MPS VAX monitor and control software architecture

    The new Machine Protection System (MPS) now being tested at the SLAC Linear Collider (SLC) includes monitoring and controlling facilities integrated into the existing VAX control system. The actual machine protection is performed by VME micros which control the beam repetition rate on a pulse-by-pulse basis based on measurements from fault detectors. The VAX is used to control and configure the VME micros, configure custom CAMAC modules providing the fault detector inputs, monitor and report faults and system errors, update the SLC database, and interface with the user. The design goals of the VAX software include a database-driven system to allow configuration changes without code changes, use of a standard TCP/IP-based message service for communication, use of existing SLCNET micros for CAMAC configuration, security and verification features to prevent unauthorized access, error and alarm logging and display updates as quickly as possible, and use of touch panels and X-windows displays for the user interface

  11. MPS Vax monitor and control software architecture

    The new Machine Protection System (MPS) now being tested at the SLAC Linear Collider (SLC) includes monitoring and controlling facilities integrated into the existing VAX control system. The actual machine protection is performed by VME micros which control the beam repetition rate on a pulse-by-pulse basis based on measurements from fault detectors. The VAX is used to control and configure the VME micros, configure custom CAMAC modules providing the fault detector inputs, monitor and report faults and system errors, update the SLC database, and interface with the user. The design goals of the VAX software include a database-driven system to allow configuration changes without code changes, use of a standard TCP/IP-based message service for communication, use of existing SLCNET micros for CAMAC configuration, security and verification features to prevent unauthorized access, error and alarm logging and display updates as quickly as possible, and use of touch panels and X-windows displays for the user interface

  12. Development of d.c. power supply for gyrotron with energy recovery system

    A new type of power supply system for a gyrotron with collector potential depression (CPD) to enhance gyrotron efficiency was developed. The power supply system is composed of a main power supply (MPS) and an acceleration power supply (APS). The APS which provides the stable high field to the magnetron injection gun (MIG) of the gyrotron is the key point of the system. The DC-DC converter technique is applied to the APS and it can output 100 kV of maximum voltage within 0.5% stability and 300 mA of maximum current. The CPD gyrotron operation was successfully achieved with an efficiency of 48% and power of 350 kW for 5 s at 110 GHz. The stable gyrotron operation, without regulation of MPS, which provides the d.c. input power to the gyrotron, has been demonstrated by the combination of the APS and MPS. (orig.)

  13. SOD1 nanozyme with reduced toxicity and MPS accumulation.

    Jiang, Yuhang; Arounleut, Phonepasong; Rheiner, Steven; Bae, Younsoo; Kabanov, Alexander V; Milligan, Carol; Manickam, Devika S

    2016-06-10

    We previously developed a "cage"-like nano-formulation (nanozyme) for copper/Zinc superoxide dismutase (SOD1) by polyion condensation with a conventional block copolymer poly(ethylene glycol)-b-poly(L-lysine) (PEG-PLL) followed by chemical cross-linking. Herein we report a new SOD1 nanozyme based on PEG-b-poly(aspartate diethyltriamine) (PEG-PAsp(DET), or PEG-DET for short) engineered for chronic dosing. This new nanozyme was spherical (Rg/Rh=0.785), and hollow (60% water composition) nanoparticles with colloidal properties similar to PLL-based nanozyme. It was better tolerated by brain microvessel endothelial/neuronal cells, and accumulated less in the liver and spleen. This formulation reduced the infarct volumes by more than 50% in a mouse model of ischemic stroke. However, it was not effective at preventing neuromuscular junction denervation in a mutant SOD1(G93A) mouse model of amyotrophic lateral sclerosis (ALS). To our knowledge, this work is the first report of using PEG-DET for protein delivery and a direct comparison between two cationic block copolymers demonstrating the effect of polymer structure in modulating the mononuclear phagocyte system (MPS) accumulation of polyion complexes. PMID:26928528

  14. Seed-mediated synthesis and structural analysis of hierarchical silver microparticles (HiAgMPs) with highly nanotextured surfaces

    Highlights: Hierarchical silver microparticles (HiAgMPs) were synthesized by the seed-mediated method using silver nanoplates as seeds. The growth of HiAgMPs under various synthetic conditions was analyzed by time-dependent scanning electron microscopy. The internal structure of HiAgMPs was thoroughly investigated by direct electron microscopic observation and N2 isotherm. - Abstract: We developed a novel method to synthesize hierarchical silver microparticles (HiAgMPs) with highly nanotextured surfaces based on the seed-mediated synthesis by using silver nanoplates as seeds. The synthetic conditions for the resultant HiAgMPs were intensively investigated with various types and concentrations of nanoparticle seeds at different Ag+ concentrations. The growth mechanism of the HiAgMPs was studied by monitoring the morphological evolution at different growth phases. Importantly, we, for the first time, analyzed the internal structure of the HiAgMPs, which are composed of a packed core surrounded by a grooved shell. The catalytic properties of the HiAgMPs were investigated and determined to be highly active for the reduction of 4-nitrophenol

  15. Fully-automated field mapping of a dipole magnet of a multi-passage spectrometer (MPS)

    Meissner, Robert; Thirolf, Peter; Weber, Christine [Fakultaet fuer Physik, LMU - Muenchen (Germany)

    2013-07-01

    MLLTRAP is a Penning-trap mass-spectrometer facility, which is currently being commissioned at the Maier-Leibnitz Laboratory in Garching. Here, atomic mass values are determined by measuring cyclotron frequencies of stored ions in a strong magnetic field. In the future, highly-charged ions should be utilized for an improvement in the achievable mass accuracy. For this purpose, singly-charged ions will have to be injected into a charge-breeding device, such as an EBIT, and transferred back towards the Penning traps, while being q/A selected. To fulfill these tasks a multi-passage-spectrometer (MPS) is being built. It consists of a fast-ramping, round-pole dipole magnet with an electrostatic mirror system. A basic requirement for building the MPS is a detailed knowledge on the magnetic field produced by the magnet. It is necessary to simulate the trajectories of the ions and gain knowledge on the design and geometry of the electrostatic mirror system and the vacuum chamber. For this purpose, a robot was designed, which - powered by three step motors - measures the magnetic field fully automated. The robot moves a Hall probe within three dimensions with a resolution of 1 mm and an uncertainty of 0.5 mm. In this presentation, the development of the robot, its control and data acquisition via LabView and the results are presented.

  16. Fully-automated field mapping of a dipole magnet of a multi-passage spectrometer (MPS)

    MLLTRAP is a Penning-trap mass-spectrometer facility, which is currently being commissioned at the Maier-Leibnitz Laboratory in Garching. Here, atomic mass values are determined by measuring cyclotron frequencies of stored ions in a strong magnetic field. In the future, highly-charged ions should be utilized for an improvement in the achievable mass accuracy. For this purpose, singly-charged ions will have to be injected into a charge-breeding device, such as an EBIT, and transferred back towards the Penning traps, while being q/A selected. To fulfill these tasks a multi-passage-spectrometer (MPS) is being built. It consists of a fast-ramping, round-pole dipole magnet with an electrostatic mirror system. A basic requirement for building the MPS is a detailed knowledge on the magnetic field produced by the magnet. It is necessary to simulate the trajectories of the ions and gain knowledge on the design and geometry of the electrostatic mirror system and the vacuum chamber. For this purpose, a robot was designed, which - powered by three step motors - measures the magnetic field fully automated. The robot moves a Hall probe within three dimensions with a resolution of 1 mm and an uncertainty of 0.5 mm. In this presentation, the development of the robot, its control and data acquisition via LabView and the results are presented.

  17. BNL multiparticle spectrometer (MPS) program

    The design and operation of the BNL multiparticle spectrometer are described. Also a formation experiment anti pp → n/sub c/ → final state was studied at 3.7 to 4.2 GeV/c tuning the total cm energy of the anti pp system to lie near the just below the J mass to search for the existence of a narrow peak (J/sup PC/ = O/sup -+ /GAMMAν several MeV). No outstanding peak is seen, but an approximate cross section limit is given in the region of a few microbarns. There is a clear K0 signal. Also a plot of the effective mass and missing mass for events with two neutral K's produced by 8.7-GeV/c π- on hydrogen is given

  18. Develop and Evaluate the Effects of Multimodal Presentation System on Elementary ESL Students

    Kuo, Fang-O; Yu, Pao-Ta; Hsiao, Wei-Hung

    2013-01-01

    The purpose of this study is to develop and evaluate the effects of multimodal presentation system (MPS), a multimodal presentation software integrated with interactive whiteboard (IWB), on student learning in the elementary English as second language (ESL) course. It focuses primarily on techniques and tools to enhance the students' ESL…

  19. Reservoir Modeling by Data Integration via Intermediate Spaces and Artificial Intelligence Tools in MPS Simulation Frameworks

    Ahmadi, Rouhollah, E-mail: rouhollahahmadi@yahoo.com [Amirkabir University of Technology, PhD Student at Reservoir Engineering, Department of Petroleum Engineering (Iran, Islamic Republic of); Khamehchi, Ehsan [Amirkabir University of Technology, Faculty of Petroleum Engineering (Iran, Islamic Republic of)

    2013-12-15

    Conditioning stochastic simulations are very important in many geostatistical applications that call for the introduction of nonlinear and multiple-point data in reservoir modeling. Here, a new methodology is proposed for the incorporation of different data types into multiple-point statistics (MPS) simulation frameworks. Unlike the previous techniques that call for an approximate forward model (filter) for integration of secondary data into geologically constructed models, the proposed approach develops an intermediate space where all the primary and secondary data are easily mapped onto. Definition of the intermediate space, as may be achieved via application of artificial intelligence tools like neural networks and fuzzy inference systems, eliminates the need for using filters as in previous techniques. The applicability of the proposed approach in conditioning MPS simulations to static and geologic data is verified by modeling a real example of discrete fracture networks using conventional well-log data. The training patterns are well reproduced in the realizations, while the model is also consistent with the map of secondary data.

  20. Reservoir Modeling by Data Integration via Intermediate Spaces and Artificial Intelligence Tools in MPS Simulation Frameworks

    Conditioning stochastic simulations are very important in many geostatistical applications that call for the introduction of nonlinear and multiple-point data in reservoir modeling. Here, a new methodology is proposed for the incorporation of different data types into multiple-point statistics (MPS) simulation frameworks. Unlike the previous techniques that call for an approximate forward model (filter) for integration of secondary data into geologically constructed models, the proposed approach develops an intermediate space where all the primary and secondary data are easily mapped onto. Definition of the intermediate space, as may be achieved via application of artificial intelligence tools like neural networks and fuzzy inference systems, eliminates the need for using filters as in previous techniques. The applicability of the proposed approach in conditioning MPS simulations to static and geologic data is verified by modeling a real example of discrete fracture networks using conventional well-log data. The training patterns are well reproduced in the realizations, while the model is also consistent with the map of secondary data

  1. Fuzzy Multi-Objective Linear Programming and Simulation Approach to the Development of Valid and Realistic Master Production Schedule

    Supriyanto, Ilham; Noche, Bernd

    2011-01-01

    Master production schedule (MPS) plays an important role in an integrated production planning system. It converts the strategic planning defined in a production plan into the tactical operation execution. The MPS is also known as a tool for top management to control over manufacture resources and becomes input of the downstream planning levels such as material requirement planning (MRP) and capacity requirement planning (CRP). Hence, inappropriate decision on the MPS development may lead to i...

  2. Numerical analysis of fuel-coolant interactions in coolant injection mode using MPS

    The numerical method used in this study is the Moving Particle Semi-implicit (MPS) method which is based on moving particles and their interactions. Grids are not necessary, so that large fluid deformation can be calculated without numerical diffusion. Boiling and solidification models are developed for the MPS method. Melt injection is calculated considering boiling and solidification. Clusters of melt particles appear due to solidification. To understand the fundamental physics of the jet penetration, water jet injection into a pool of a denser fluid under non-boiling and isothermal conditions are calculated using the MPS method. The density ratio of the denser fluid to water is 1.88 (fluorinert) or 9.4 (anatomical alloy). The calculation results are compared with experiments, which were conducted in the ALPHA/MUSE facility at JAERI. In the calculation, air entrainment is observed as the experiments due to the jet penetration. However, the maximum jet penetration depth is shallower than the experiments. (author)

  3. Mps1 (Monopolar Spindle 1) Protein Inhibition Affects Cellular Growth and Pro-Embryogenic Masses Morphology in Embryogenic Cultures of Araucaria angustifolia (Araucariaceae)

    Douétts-Peres, Jackellinne C.; Cruz, Marco Antônio L.; Reis, Ricardo S.; Heringer, Angelo S.; de Oliveira, Eduardo A. G.; Elbl, Paula M.; Floh, Eny I. S.; Silveira, Vanildo

    2016-01-01

    Somatic embryogenesis has been shown to be an efficient tool for studying processes based on cell growth and development. The fine regulation of the cell cycle is essential for proper embryo formation during the process of somatic embryogenesis. The aims of the present work were to identify and perform a structural and functional characterization of Mps1 and to analyze the effects of the inhibition of this protein on cellular growth and pro-embryogenic mass (PEM) morphology in embryogenic cultures of A. angustifolia. A single-copy Mps1 gene named AaMps1 was retrieved from the A. angustifolia transcriptome database, and through a mass spectrometry approach, AaMps1 was identified and quantified in embryogenic cultures. The Mps1 inhibitor SP600125 (10 μM) inhibited cellular growth and changed PEMs, and these effects were accompanied by a reduction in AaMps1 protein levels in embryogenic cultures. Our work has identified the Mps1 protein in a gymnosperm species for the first time, and we have shown that inhibiting Mps1 affects cellular growth and PEM differentiation during A. angustifolia somatic embryogenesis. These data will be useful for better understanding cell cycle control during somatic embryogenesis in plants. PMID:27064899

  4. Mps1 promotes rapid centromere accumulation of Aurora B

    Vleugel, Mathijs; van der Waal, Maike S.; Vromans, Martijn J. M.; Lens, Susanne M.A.; Medema, Rene H.; Kops, Geert J. P. L.; Wurzenberger, Claudia; Gerlich, Daniel W; Saurin, Adrian T.

    2012-01-01

    Mps1 is shown to stimulate Aurora B centromere recruitment through the Bub1H2A phosphorylation-Shugoshin pathway. This recruitment circuitry ensures rapid accumulation of Aurora B at the onset of mitosis and proper chromosome biorientation.

  5. Nano-WO3 film modified macro-porous silicon (MPS) gas sensor

    Peng, Sun; Ming, Hu; Mingda, Li; Shuangyun, Ma

    2012-05-01

    We prepared macro-porous silicon (MPS) by electrochemical corrosion in a double-tank cell on the surface of single-crystalline P-type silicon. Then, nano-WO3 films were deposited on MPS layers by DC facing target reactive magnetron sputtering. The morphologies of the MPS and WO3/MPS samples were investigated by using a field emission scanning electron microscope. The crystallization of WO3 and the valence of the W in the WO3/MPS sample were characterized by X-ray diffraction and X-ray photoelectron spectroscopy, respectively. The gas sensing properties of MPS and WO3/MPS gas sensors were thoroughly measured at room temperature. It can be concluded that: the WO3/MPS gas sensor shows the gas sensing properties of a P-type semiconductor gas sensor. The WO3/MPS gas sensor exhibits good recovery characteristics and repeatability to 1 ppm NO2. The addition of WO3 can enhance the sensitivity of MPS to NO2. The long-term stability of a WO3/MPS gas sensor is better than that of an MPS gas sensor. The sensitivity of the WO3/MPS gas sensor to NO2 is higher than that to NH3 and C2H5OH. The selectivity of the MPS to NO2 is modified by deposited nano-WO3 film.

  6. Nano-WO3 film modified macro-porous silicon (MPS) gas sensor

    We prepared macro-porous silicon (MPS) by electrochemical corrosion in a double-tank cell on the surface of single-crystalline P-type silicon. Then, nano-WO3 films were deposited on MPS layers by DC facing target reactive magnetron sputtering. The morphologies of the MPS and WO3/MPS samples were investigated by using a field emission scanning electron microscope. The crystallization of WO3 and the valence of the W in the WO3/MPS sample were characterized by X-ray diffraction and X-ray photoelectron spectroscopy, respectively. The gas sensing properties of MPS and WO3/MPS gas sensors were thoroughly measured at room temperature. It can be concluded that: the WO3/MPS gas sensor shows the gas sensing properties of a P-type semiconductor gas sensor. The WO3/MPS gas sensor exhibits good recovery characteristics and repeatability to 1 ppm NO2. The addition of WO3 can enhance the sensitivity of MPS to NO2. The long-term stability of a WO3/MPS gas sensor is better than that of an MPS gas sensor. The sensitivity of the WO3/MPS gas sensor to NO2 is higher than that to NH3 and C2H5OH. The selectivity of the MPS to NO2 is modified by deposited nano-WO3 film. (semiconductor devices)

  7. CONDENSED MATTER: ELECTRONIC STRUCTURE, ELECTRICAL, MAGNETIC, AND OPTICAL PROPERTIES: Analytical model for reverse characteristics of 4H-SiC merged PN-Schottky (MPS) diodes

    Song, Qing-Wen; Zhang, Yu-Ming; Zhang, Yi-Men; Lü, Hong-Liang; Chen, Feng-Ping; Zheng, Qing-Li

    2009-12-01

    A new analytical model for reverse characteristics of 4H-SiC merged PN-Schottky diodes (MPS or JBS) is developed. To accurately calculate the reverse characteristics of the 4H-SiC MPS diode, the relationship between the electric field at the Schottky contact and the reverse bias is analytically established by solving the cylindrical Poisson equation after the channel has pinched off. The reverse current density calculated from the Wentzel-Kramers-Brillouin (WKB) theory is verified by comparing it with the experimental result, showing that they are in good agreement with each other. Moreover, the effects of P-region spacing (S) and P-junction depth (Xj) on the characteristics of 4H-SiC MPS are analysed, and are particularly useful for optimizing the design of the high voltage MPS diodes.

  8. A preliminary design proposal for a maritime patrol strike aircraft: MPS-2000 Condor

    1994-01-01

    The four member graduate design team assembled to submit a proposal for the 1993/1994 RFP at the University of Kansas has designed a four seat, variable swept wing, twin turbofan aircraft with STOL capabilities. The aircraft is named the MPS-2000 Condor and is capable of carrying air-to-surface or air-to-air weapon systems along with attack and surveillance radar and IRF systems. The aircraft has a cruise range of 800 nautical miles, a loiter of 4 hours, and a dash speed of 500 kts.

  9. Mutations in ARSB in MPS VI patients in India

    Juby Mathew

    2015-09-01

    Full Text Available Mucopolysaccharidosis VI (MPS VI is an autosomal recessive inborn error of metabolism caused by mutations in the arylsulfatase B gene (ARSB and consequent deficient activity of ARSB, a lysosomal enzyme. We present here the results of a study undertaken to identify the mutations in ARSB in MPS VI patients in India. Around 160 ARSB mutations, of which just 4 are from India, have been reported in the literature. Our study covered nine MPS VI patients from eight families. Both familial mutations were found in seven families, and only one mutation was found in one family. Seven mutations were found four novel (p.G38_G40del3, p.C91R, p.L98R and p.R315P, two previously reported from India (p.D53N and p.W450C, and one reported from outside India (p.R160Q. One mutation, p.W450C, was present in two families, and the other six mutations were present in one family each. Analysis of the molecular structure of the enzyme revealed that most of these mutations either cause loss of an active site residue or destabilize the structure of the enzyme. The only previous study on mutations in ARSB in Indian MPS VI patients, by Kantaputra et al. 2014 [1], reported four novel mutations of which two (p.D53N and p.W450C were found in our study as well. Till date, nine mutations have been reported from India, through our study and the Kantaputra study. Eight out of these nine mutations have been found only in India. This suggests that the population studied by us might have its own typical set of mutations, with other populations equally likely to have their own set of mutations.

  10. Neonatal Bone Marrow Transplantation in MPS IIIA Mice

    Adeline A. Lau; Shamsani, N Jannah; Winner, Leanne K; Hassiotis, Sofia; King, Barbara M.; Hopwood, John J; Hemsley, Kim M.

    2012-01-01

    Patients with some neurological lysosomal storage disorders (LSD) exhibit improved clinical signs following bone marrow transplantation (BMT). The failure of mucopolysaccharidosis (MPS) type IIIA patients and adult mice with the condition to respond to this treatment may relate to factors such as impaired migration of donor-derived cells into the brain, insufficient enzyme production and/or secretion by the donor-derived microglial cells, or the age at which treatment is initiated. To explore...

  11. OA@MPS - a colourful view

    Romary, L.

    2007-01-01

    The open access agenda of the Max Planck Society, initiator of the Berlin Declaration, envisions the support of both the green way and the golden way to open access. For the implementation of the green way the Max Planck Society through its newly established unit (Max Planck Digital Library) follows the idea of providing a centralized technical platform for publications and a local support for editorial issues. With regard to the golden way, the Max Planck Society fosters the development of o...

  12. MPS on the Hunt for Planets

    Rhie, S H

    1999-01-01

    Planetary systems toward the Galactic Bulge can be detected through microlensing measurements. The microlensing planet search technique has some unique merits: low-mass planets can be detected from the ground; the Galactic family of planetary systems can be sampled unbiased; the time scale for the completion of each event is relatively short. The unambiguity of the underlying low-multiplicity point lenses is an indispensable element that allows robust interpretaion of the events. We have found the first circumbinary planet in the microlensing event MACHO-97-BLG-41. We have found evidence of a low mass planet (few Earths to Neptune mass) in a very high magnification event MACHO-98-BLG-35. We emphasize the necessity for coherent searches of microlensing planets with a network of instruments in the southern hemisphere. The network can also be vitally instrumental for follow-up observations of SN1a's and GRB's which share with microlensing planets the transiency as well as the clues to our quest of the origins.

  13. Numerical analysis of molten core-concrete interaction using MPS method

    Moving particle semi-implicit (MPS) method uses particles for discretization of fluids. Governing equations are transformed to particle interactions. Grids are not necessary. This enables us to analyze multi-fluid and multi-phase flows with large deformation of interfaces. In the present study, a two-dimensional code is developed for molten core-concrete interaction (MCCI) based on the MPS method. Heat transfer is calculated without any specific correlations. Solid is simply represented by fixed particles. A particle can be changed to a moving (fluid) or fixed (solid) particle corresponding to its enthalpy. The developed code is applied to SWISS-2 experiment. The calculation geometry is x-y two dimensions though the experiment was r-z two dimensions. Nucleate boiling and radiation heat transfers are considered between the melt and the water pool. Only heat conduction is assumed among the melt pool, concrete and MgO (side wills). Natural convection in the melt pool is considered using Boussinesq's approximation. Gas release and volume contraction accompanied by the concrete ablation are ignored. Calculated heat flux to the water pool agrees well with the experiment, though the ablation speed in the concrete is a little slower. A stable crust is formed in a short time after water is poured in and the heat flux to the water pool rapidly decreases. The shape of the crust is like a bridge due to the natural convection in the melt pool. (author)

  14. A simple electrochemical biosensor based on AuNPs/MPS/Au electrode sensing layer for monitoring carbamate pesticides in real samples.

    Song, Yonghai; Chen, Jingyi; Sun, Min; Gong, Coucong; Shen, Yuan; Song, Yonggui; Wang, Li

    2016-03-01

    A simple electrochemical biosensor for quantitative determination of carbamate pesticide was developed based on a sensing interface of citrate-capped gold nanoparticles (AuNPs)/(3-mercaptopropyl)-trimethoxysilane (MPS)/gold electrode (Au). The biosensor was fabricated by firstly assembling three-dimensional (3D) MPS networks on Au electrode and subsequently assembling citrate-capped AuNPs on 3D MPS network via AuS bond. The interface of AuNPs/MPS/Au was negatively charged originating from the citrate coated on AuNPs that would repulse the negatively charged ferricyanide ([Fe(CN)6](3-/4-)) to produce a negative response. In the presence of acetylcholinesterase (AChE) and acetylthiocholine (ATCl), the AChE catalyzes the hydrolysis of ATCl into positively charged thiocholine which would replace the citrate on AuNPs through the strong AuS bond and convert the negative charged surface to be positively charged. The resulted positively charged AuNPs/MPS/Au then attracted the [Fe(CN)6](3-/4-) to produce a positive response. Based on the inhibition of carbamate pesticides on the activity of AChE, the pesticide could be quantitatively determined at a very low potential. The linear range was from 0.003 to 2.00?M. The sensing platform was also proved to be suitable for carbamate pesticides detection in practical sample. PMID:26547618

  15. MRI morphometric characterisation of the paediatric cervical spine and spinal cord in children with MPS IVA (Morquio-Brailsford syndrome)

    Solanki, Guirish A; Lo, William B; Christian J. Hendriksz

    2013-01-01

    Nearly all children with MPS IVA develop skeletal deformities affecting the spine. At the atlanto-axial spine, odontoid hypoplasia occurs. GAG deposition around the dens, leads to peri-odontoid infiltration. Transverse/alar ligament incompetence causes instability. Atlanto-axial instability is associated with cord compression and myelopathy, leading to major morbidity and mortality. Intervention is often required. Does the presence of widened bullet shaped vertebra in platyspondily encroach o...

  16. The relevance and potential roles of microphysiological systems in biology and medicine

    Wikswo, John P.

    2014-01-01

    Microphysiological systems (MPS), consisting of interacting organs-on-chips or tissue-engineered, 3D organ constructs that use human cells, present an opportunity to bring new tools to biology, medicine, pharmacology, physiology, and toxicology. This issue of Experimental Biology and Medicine describes the ongoing development of MPS that can serve as in vitro models for bone and cartilage, brain, gastrointestinal tract, lung, liver, microvasculature, reproductive tract, skeletal muscle, and s...

  17. Evaluation of enzyme dose and dose-frequency in ameliorating substrate accumulation in MPS IIIA Huntaway dog brain.

    King, Barbara; Marshall, Neil; Beard, Helen; Hassiotis, Sofia; Trim, Paul J; Snel, Marten F; Rozaklis, Tina; Jolly, Robert D; Hopwood, John J; Hemsley, Kim M

    2015-03-01

    Intracerebrospinal fluid (CSF) infusion of replacement enzyme is under evaluation for amelioration of disease-related symptoms and biomarker changes in patients with the lysosomal storage disorder mucopolysaccharidosis type IIIA (MPS IIIA; www.clinicaltrials.gov ; NCT#01155778; #01299727). Determining the optimal dose/dose-frequency is important, given the invasive method for chronically supplying recombinant protein to the brain, the main site of symptom generation. To examine these variables, we utilised MPS IIIA Huntaway dogs, providing recombinant human sulphamidase (rhSGSH) to young pre-symptomatic dogs from an age when MPS IIIA dog brain exhibits significant accumulation of primary (heparan sulphate) and secondary (glycolipid) substrates. Enzyme was infused into CSF via the cisterna magna at one of two doses (3 mg or 15 mg/infusion), with the higher dose supplied at two different intervals; fortnightly or monthly. Euthanasia was carried out 24 h after the final injection. Dose- and frequency-dependent reductions in heparan sulphate were observed in CSF and deeper layers of cerebral cortex. When we examined the amount of immunostaining of the general endo/lysosomal marker, LIMP-2, or quantified activated microglia, the higher fortnightly dose resulted in superior outcomes in affected dogs. Secondary lesions such as accumulation of GM3 ganglioside and development of GAD-reactive axonal spheroids were treated to a similar degree by both rhSGSH doses and dose frequencies. Our findings indicate that the lower fortnightly dose is sub-optimal for ameliorating existing and preventing further development of disease-related pathology in young MPS IIIA dog brain; however, increasing the dose fivefold but halving the frequency of administration enabled near normalisation of disease-related biomarkers. PMID:25421091

  18. Dicodon monitoring of protein synthesis (DiCoMPS) reveals levels of synthesis of a viral protein in single cells.

    Barhoom, Sima; Farrell, Ian; Shai, Ben; Dahary, Dvir; Cooperman, Barry S; Smilansky, Zeev; Elroy-Stein, Orna; Ehrlich, Marcelo

    2013-10-01

    The current report represents a further advancement of our previously reported technology termed Fluorescent transfer RNA (tRNA) for Translation Monitoring (FtTM), for monitoring of active global protein synthesis sites in single live cells. FtTM measures Förster resonance energy transfer (FRET) signals, generated when fluorescent tRNAs (fl-tRNAs), separately labeled as a FRET pair, occupy adjacent sites on the ribosome. The current technology, termed DiCodon Monitoring of Protein Synthesis (DiCoMPS), was developed for monitoring active synthesis of a specific protein. In DiCoMPS, specific fl-tRNA pair combinations are selected for transfection, based on the degree of enrichment of a dicodon sequence to which they bind in the mRNA of interest, relative to the background transcriptome of the cell in which the assay is performed. In this study, we used cells infected with the Epizootic Hemorrhagic Disease Virus 2-Ibaraki and measured, through DiCoMPS, the synthesis of the viral non-structural protein 3 (NS3), which is enriched in the AUA:AUA dicodon. fl-tRNA(Ile)UAU-generated FRET signals were specifically enhanced in infected cells, increased in the course of infection and were diminished on siRNA-mediated knockdown of NS3. Our results establish an experimental approach for the single-cell measurement of the levels of synthesis of a specific viral protein. PMID:23965304

  19. Centriole assembly and the role of Mps1: defensible or dispensable?

    Fisk Harold A

    2011-04-01

    Full Text Available Abstract The Mps1 protein kinase is an intriguing and controversial player in centriole assembly. Originally shown to control duplication of the budding yeast spindle pole body, Mps1 is present in eukaryotes from yeast to humans, the nematode C. elegans being a notable exception, and has also been shown to regulate the spindle checkpoint and an increasing number of cellular functions relating to genomic stability. While its function in the spindle checkpoint appears to be both universally conserved and essential in most organisms, conservation of its originally described function in spindle pole duplication has proven controversial, and it is less clear whether Mps1 is essential for centrosome duplication outside of budding yeast. Recent studies of Mps1 have identified at least two distinct functions for Mps1 in centriole assembly, while simultaneously supporting the notion that Mps1 is dispensable for the process. However, the fact that at least one centrosomal substrate of Mps1 is conserved from yeast to humans down to the phosphorylation site, combined with evidence demonstrating the exquisite control exerted over centrosomal Mps1 levels suggest that the notion of being essential may not be the most important of distinctions.

  20. Surveys of MPs and Senators in the Parlament of the Czech Republic between 1993 and 2005

    Linek, Lukáš

    2005-01-01

    Roč. 41, č. 3 (2005), s. 487-498. ISSN 0038-0288 R&D Projects: GA MPS(CZ) 1J004/04-DP1 Keywords : parliamentary party groups * surveys of MPs * legislative behaviour Subject RIV: AO - Sociology, Demography Impact factor: 0.113, year: 2005

  1. Human swallowing simulation based on videofluorography images using Hamiltonian MPS method

    Kikuchi, Takahiro; Michiwaki, Yukihiro; Kamiya, Tetsu; Toyama, Yoshio; Tamai, Tasuku; Koshizuka, Seiichi

    2015-09-01

    In developed nations, swallowing disorders and aspiration pneumonia have become serious problems. We developed a method to simulate the behavior of the organs involved in swallowing to clarify the mechanisms of swallowing and aspiration. The shape model is based on anatomically realistic geometry, and the motion model utilizes forced displacements based on realistic dynamic images to reflect the mechanisms of human swallowing. The soft tissue organs are modeled as nonlinear elastic material using the Hamiltonian MPS method. This method allows for stable simulation of the complex swallowing movement. A penalty method using metaballs is employed to simulate contact between organ walls and smooth sliding along the walls. We performed four numerical simulations under different analysis conditions to represent four cases of swallowing, including a healthy volunteer and a patient with a swallowing disorder. The simulation results were compared to examine the epiglottic downfolding mechanism, which strongly influences the risk of aspiration.

  2. S-system-based analysis of the robust properties common to many biochemical network models.

    Matsuoka, Yu; Jahan, Nusrat; Kurata, Hiroyuki

    2016-05-01

    Robustness is a key feature to characterize the adaptation of organisms to changes in their internal and external environments. A broad range of kinetic or dynamic models of biochemical systems have been developed. Robustness analyses are attractive for exploring some common properties of many biochemical models. To reveal such features, we transform different types of mathematical equations into a standard or intelligible formula and use the multiple parameter sensitivity (MPS) to identify some factors critically responsible for the total robustness to many perturbations. The MPS would be determined by the top quarter of the highly sensitive parameters rather than the single parameter with the maximum sensitivity. The MPS did not show any correlation to the network size. The MPS is closely related to the standard deviation of the sensitivity profile. A decrease in the standard deviation enhanced the total robustness, which shows the hallmark of distributed robustness that many factors (pathways) involve the total robustness. PMID:26861555

  3. Heterologous Expression and Purification Systems for Structural Proteomics of Mammalian Membrane Proteins

    Isabelle Mus-Veteau

    2006-04-01

    Full Text Available Membrane proteins (MPs are responsible for the interface between the exterior and the interior of the cell. These proteins are implicated in numerous diseases, such as cancer, cystic fibrosis, epilepsy, hyperinsulinism, heart failure, hypertension and Alzheimer's disease. However, studies on these disorders are hampered by a lack of structural information about the proteins involved. Structural analysis requires large quantities of pure and active proteins. The majority of medically and pharmaceutically relevant MPs are present in tissues at very low concentration, which makes heterologous expression in large-scale production-adapted cells a prerequisite for structural studies. Obtaining mammalian MP structural data depends on the development of methods that allow the production of large quantities of MPs. This review focuses on the different heterologous expression systems, and the purification strategies, used to produce large amounts of pure mammalian MPs for structural proteomics.

  4. A new single-station wMPS measurement method with distance measurement

    Xie, Yu; Lin, Jiarui; Yang, Linghui; Guo, Yin; Zhao, Ziyue

    2015-10-01

    Multi-task and real-time measurement of relative displacement is widely needed in the present industrial field. Existing measuring methods require complex preparation and data processing, or are unable meet the requirement of automation, multi-task and real-time. The instruments used to measure absolute coordinates are inefficiency because of the measured target is relative displacement. A new single-station wMPS (Workspace Measuring Position System) measurement method combined distance measurement is presented in this paper. It learns from measuring principle of total station, measures angle based on rotating scanning laser plane measuring method, and measures distance based on optoelectronic scanning multi-angle intersection location principle, uses the angle-length resection measuring method, builds a new mathematical model to measure the relative displacement of the target. The result of experiment proves that it increases measuring efficiency and achieves multi-task and real-time measurement of relative displacement.

  5. The safety of anginine in patients undergoing myocardial perfusion scintigraphy (MPS)- a nurses' perspective

    Full text: Anginine-augmented MPS improves detection rate of myocardial viability and reversible ischaemia. However, anginine can cause significant hypotension. The aims of this study were to determine i) safety of anginine in patients with an intermediate to high risk of myocardial ischaemia undergoing MPS; ii) frequency and degree of fall in systolic blood pressure (SBP); iii) BP monitoring requirements; and iv) type of patient(s) prone to side effects. 63 patients (33M, 30F, mean age-67.2y) were included. Each was cannulated, drank two glasses of water, and lay supine prior to administration of anginine (1 x puff sublingually). 99Tcm-MIBI was administered 3-5 minutes later. BP measurements were obtained every five minutes for 20 minutes. SBP fell in 46/63 patients (range 5 - 40mmHg, mean 1 6mmHg, in 14 fall >20mmHg), and rose in 14/63. Maximal fall occurred 5-15 minutes post-administration of anginine (14 at 5min, 15 at 10min, 17 at 15min), returning toward baseline by 20 minutes in all patients. Seven patients developed a headache and two light-headedness; in all SBP fell >10mmHg. The quality of the scans was unaffected. There were 22(35%) abnormal studies - 14 reversible defects, two fixed defects, six cardiomyopathy (mean SBP tall 8.1mmHg, 8.6mmHg with normal study). LVEF was obtained in 33 patients; SBP fell in 24 (mean LVEF 57.8%), and rose in nine (mean LVEF 56.8%). The frequency and extent of hypotension in relation to age, sex, LVEF, or scan findings was not statistically significant. Anginine is sate to administer to patients undergoing MPS. Careful monitoring of the BP is recommended during the initial 20 minutes post-administration. No particular patient type was identified at higher risk. Copyright (2000) The Australian and New Zealand Society of Nuclear Medicine Inc

  6. Residual glycosaminoglycan accumulation in mitral and aortic valves of a patient with attenuated MPS I (Scheie syndrome after 6 years of enzyme replacement therapy: Implications for early diagnosis and therapy

    Yohei Sato

    2015-12-01

    Full Text Available Mucopolysaccharidosis (MPS is an inherited metabolic disease caused by deficiency of the enzymes needed for glycosaminoglycan (GAG degradation. MPS type I is caused by the deficiency of the lysosomal enzyme alpha-l-iduronidase and is classified into Hurler syndrome, Scheie syndrome, and Hurler–Scheie syndrome based on disease severity and onset. Cardiac complications such as left ventricular hypertrophy, cardiac valve disease, and coronary artery disease are often observed in MPS type I. Enzyme replacement therapy (ERT has been available for MPS type I, but the efficacy of this treatment for cardiac valve disease is unknown. We report on a 56-year-old female patient with attenuated MPS I (Scheie syndrome who developed aortic and mitral stenosis and coronary artery narrowing. The cardiac valve disease progressed despite ERT and she finally underwent double valve replacement and coronary artery bypass grafting. The pathology of the cardiac valves revealed GAG accumulation and lysosomal enlargement in both the mitral and aortic valves. Zebra body formation was also confirmed using electron microscopy. Our results suggest that ERT had limited efficacy in previously established cardiac valve disease. Early diagnosis and initiation of ERT is crucial to avoid further cardiac complications in MPS type I.

  7. X-34 Main Propulsion System Design and Operation

    Champion, R. J., Jr.; Darrow, R. J., Jr.

    1998-01-01

    The X-34 program is a joint industry/government program to develop, test, and operate a small, fully-reusable hypersonic flight vehicle, utilizing technologies and operating concepts applicable to future Reusable Launch Vehicle (RLV) systems. The vehicle will be capable of Mach 8 flight to 250,000 feet altitude and will demonstrate an all composite structure, composite RP-1 tank, the Marshall Space Flight Center (MSFC) developed Fastrac engine, and the operability of an advanced thermal protection systems. The vehicle will also be capable of carrying flight experiments. MSFC is supporting the X-34 program in three ways: Program Management, the Fastrac engine as Government Furnished Equipment (GFE), and the design of the Main Propulsion System (MPS). The MPS Product Development Team (PDT) at MSFC is responsible for supplying the MPS design, analysis, and drawings to Orbital. The MPS consists of the LOX and RP-1 Fill, Drain, Feed, Vent, & Dump systems and the Helium & Nitrogen Purge, Pressurization, and Pneumatics systems. The Reaction Control System (RCS) design was done by Orbital. Orbital is the prime contractor and has responsibility for integration, procurement, and construction of all subsystems. The paper also discusses the design, operation, management, requirements, trades studies, schedule, and lessons learning with the MPS and RCS designs.

  8. Development of a machine protection system for the Superconducting Beam Test Facility at Fermilab

    Warner, A; Church, M; Neswold, R

    2012-01-01

    Fermilab's Superconducting RF Beam Test Facility currently under construction will produce electron beams capable of damaging the acceleration structures and the beam line vacuum chambers in the event of an aberrant accelerator pulse. The accelerator is being designed with the capability to operate with up to 3000 bunches per macro-pulse, 5Hz repetition rate and 1.5 GeV beam energy. It will be able to sustain an average beam power of 72 KW at the bunch charge of 3.2 nC. Operation at full intensity will deposit enough energy in niobium material to approach the melting point of 2500 {\\deg}C. In the early phase with only 3 cryomodules installed the facility will be capable of generating electron beam energies of 810 MeV and an average beam power that approaches 40 KW. In either case a robust Machine Protection System (MPS) is required to mitigate effects due to such large damage potentials. This paper will describe the MPS system being developed, the system requirements and the controls issues under consideratio...

  9. Cascade Distillation System Development

    Callahan, Michael R.; Sargushingh, Miriam; Shull, Sarah

    2014-01-01

    NASA's Advanced Exploration Systems (AES) Life Support System (LSS) Project is chartered with de-veloping advanced life support systems that will ena-ble NASA human exploration beyond low Earth orbit (LEO). The goal of AES is to increase the affordabil-ity of long-duration life support missions, and to re-duce the risk associated with integrating and infusing new enabling technologies required to ensure mission success. Because of the robust nature of distillation systems, the AES LSS Project is pursuing develop-ment of the Cascade Distillation Subsystem (CDS) as part of its technology portfolio. Currently, the system is being developed into a flight forward Generation 2.0 design.

  10. Industrialized Information Systems Development

    Havn, Erling; Bansler, Jørgen P.

    1996-01-01

    The production of application software is rapidly being industrialized. Computer manufacturers and software houses produce a rapidly growing number of generic software applications and systems, and more and more user companies choose to build their computer-based information systems with such...... generic products, instead of custom made software. We discuss how the move away from traditional in-house development and the increasing use of generic software is likely to transform IS development in the near future. We conclude that these developments will make new demands on the information systems...

  11. Mobile systems development

    Pedersen, Ole; Kristiansen, Martin Lund; Kammersgaard, Marc N.; Hosbond, Jens Henrik

    development teams in the mobile software industry. By taking a process view on development of mobile systems we seek to explore the strengths and limitations of eXtreme Programming (XP) in the context of mobile software development. Following an experimental approach a mobile systems development project...... components whenever possible. Test regularly oil real devices, since the difference between emulators and real devices are significant. Take advantage of spikes. Do not use pair programming when spiking, and remember to write unit tests for production code that was initially created during spikes. Monitor...

  12. Human Mps1 Kinase is required for the Mitotic Spindle Checkpoint, but not for Centrosome Duplication

    Stucke, Volker Matthias

    2003-01-01

    Die Familie der Mps1-Proteinkinasen (Monopolar spindle 1) hat mehrere wichtige Aufgaben im Zellzyklus. Mps1p wurde zuerst in S. cerevisiae gefunden und näher charakterisiert. Mps1p ist zum einen an der Verdoppelung des Spindel-Polkörperchens beteiligt und zum anderen ist die Kinase eine Komponente im mitotischen Spindelkontrollpunkt. Das Spindel-Polkörperchen ist das Centrosomäquivalent in Hefezellen und somit das Mikrotubuli-Organisationszentrum (MTOC) in Zellen. Zu Beginn der Mitose dient d...

  13. Doing Systems Development

    Koch, Christian; Mathiasen, John Bang

    2014-01-01

    Systems development of wind turbine control is competitive with respect to innovation, time and cost. So how can learning possibly occur under such circumstances? Dewey’s pragmatist approach to learning is adopted, emphasising reciprocity between the systems developer’s individual experience and...

  14. Evolutionary Information System Development

    Kristensen, Jan

    This paper offers advice to companies and professionals that implement e-commerce systems in business organizations. Implementing e-commerce systems is different from traditional IT implementation and thus requires a new set of tools and skills. The need for a novel approach is illustrated and...... business priorities. On a more theoretical level this suggests that we must revise our current understanding of systems development to cope....

  15. Numerical simulation on inertia controlled steam bubble condensation using MPS

    Chong, Daotong; Ishiwatari, Yuki; Oka, Yoshiaki; Yan, Junjie; Liu, Jiping

    2013-07-01

    Bubble dynamics is quite complicated in the field of two-phase hydrodynamics because the interfacial heat and mass transfer is comprehensively affected by various influencing factors. Bubble condensation can be either thermally controlled or inertia controlled. Inertia controlled bubble condensation indicates that considerable pressure difference exists between the steam bubble and ambient liquid. In this paper, the inertia controlled steam bubble condensation was simulated using moving particle semi-implicit (MPS) method. The spherical bubble is located in the center of the cylindrical pool which makes the possibility of 2-D axisymmetric computation. The lateral and bottom wall are set to be rigid insulated boundaries and the top is free surface boundary. The pool volume must be large enough to eliminate the effects by pool wall. The initial bubble pressure ranges from 0.48 MPa to 3.98 MPa, and the initial bubble diameter ranges from 2 mm to 5 mm, and the ambient water pressure and temperature is 0.1 MPa and 70 C, respectively. The bubble dynamics during condensation was investigated and the influences of initial bubble pressure and diameter were obtained. The bubble deformation during condensation is shown in figure 1, and the variations of bubble diameters and pressures during condensation are shown in figures 2 and 3, respectively.

  16. A generic expert system for materials processing in space

    Andersen, Kristinn; Cook, George E.; Strauss, Alvin M.

    1988-01-01

    A generic expert system is described for inspecting materials processed in space (MPS). The system may be applied, with the appropriate knowledge base, to any of the nondestructive testing methods (NDT) which are appropriate to MPS. Regardless of the method being used, the inspection process consists of three tasks: (1) signal or image processing of the NDT output and feature extraction, (2) interpretation of features in terms of MPS discontinuities, and (3) evaluation of the quality of the MPS based upon industry standards. In contrast to rule based systems, this system represents its knowledge as multidimensional vectors and appropriate functions on them. Currently, the expert system accepts manual input of observed features. Once the expert system has been tested and compared to human expert inspectors, a vision front-end will be developed to complete automation of the expert MPS inspection system, based on visual discontuities. Then the data base will be extended to include a variety of other NDT methods. In addition to functional performance, ease of use was established through menu window driven input as well as flexibility in building, using and modifying data bases for different applications.

  17. Power Systems Development Facility

    Southern Company Services

    2009-01-31

    In support of technology development to utilize coal for efficient, affordable, and environmentally clean power generation, the Power Systems Development Facility (PSDF), located in Wilsonville, Alabama, has routinely demonstrated gasification technologies using various types of coals. The PSDF is an engineering scale demonstration of key features of advanced coal-fired power systems, including a Transport Gasifier, a hot gas particulate control device, advanced syngas cleanup systems, and high-pressure solids handling systems. This final report summarizes the results of the technology development work conducted at the PSDF through January 31, 2009. Twenty-one major gasification test campaigns were completed, for a total of more than 11,000 hours of gasification operation. This operational experience has led to significant advancements in gasification technologies.

  18. A unique hinge binder of extremely selective aminopyridine-based Mps1 (TTK) kinase inhibitors with cellular activity.

    Kusakabe, Ken-ichi; Ide, Nobuyuki; Daigo, Yataro; Itoh, Takeshi; Yamamoto, Takahiko; Kojima, Eiichi; Mitsuoka, Yasunori; Tadano, Genta; Tagashira, Sachie; Higashino, Kenichi; Okano, Yousuke; Sato, Yuji; Inoue, Makiko; Iguchi, Motofumi; Kanazawa, Takayuki; Ishioka, Yukichi; Dohi, Keiji; Kido, Yasuto; Sakamoto, Shingo; Ando, Shigeru; Maeda, Masahiro; Higaki, Masayo; Yoshizawa, Hidenori; Murai, Hitoshi; Nakamura, Yusuke

    2015-05-01

    Mps1, also known as TTK, is a dual-specificity kinase that regulates the spindle assembly check point. Increased expression levels of Mps1 are observed in cancer cells, and the expression levels correlate well with tumor grade. Such evidence points to selective inhibition of Mps1 as an attractive strategy for cancer therapeutics. Starting from an aminopyridine-based lead 3a that binds to a flipped-peptide conformation at the hinge region in Mps1, elaboration of the aminopyridine scaffold at the 2- and 6-positions led to the discovery of 19c that exhibited no significant inhibition for 287 kinases as well as improved cellular Mps1 and antiproliferative activities in A549 lung carcinoma cells (cellular Mps1 IC₅₀=5.3 nM, A549 IC₅₀=26 nM). A clear correlation between cellular Mps1 and antiproliferative IC₅₀ values indicated that the antiproliferative activity observed in A549 cells would be responsible for the cellular inhibition of Mps1. The X-ray structure of 19c in complex with Mps1 revealed that this compound retains the ability to bind to the peptide flip conformation. Finally, comparative analysis of the X-ray structures of 19c, a deamino analogue 33, and a known Mps1 inhibitor bound to Mps1 provided insights into the unique binding mode at the hinge region. PMID:25801152

  19. On the Kinematic Motion Primitives (kMPs - Theory and Application

    Federico Lorenzo Moro

    2012-10-01

    Experimental tests with the COmpliant huMANoid (COMAN were performed to show that the kMPs extracted from human subjects can be used to transfer the features of human locomotion to the gait of a robot.

  20. Development of heating system

    The detailed designs and development of components of NBI, RF, ECH, and LHCD heating and current drive system have been performed. The prototype ion source for the KSTAR NBI system and the beam line components such as calorimeter, neutralizer, bending magnet, and ion dump had been developed. The power supplies for the stable beam of 120 kV and 65 A including acceleration power supply, deceleration power supply, arc power supply, and filament power supply have been developed. Finally a KSATR NB test facility has been completed at KAERI to test and upgrade the ion source and the beam line components. The RF system is under development. Antenna has been fabricated and tested. Transmission components (vacuum feedthrough, impedance matching and water-cooled transmission line) for transmitting MW level of power have been developed. For transmitter, we optimized performance of 100kW transmitter and completed the fabrication of 300 kW transmitter. We will finalize the procurement specification of 2 MW transmitter system in the third phase. The detailed design of a 500 kW, 84 GHz ECH system has been completed. The gyrotron has been fabricated and successfully tested at Communications and Power Industries(CPI), USA. It is delivered to POSTECH, and under short pulse conditioning test with a pulse modulator operated at 20 μs with 60 Hz repetition rate and a acceleration power supply (APS). The ECH transmission line components are being purchased from General Atomics (GA), USA. The LH frequency of the 2.0 MW LHCD system is chosen to 5.0 GHz for extending the density limit condition. The LHCD system is under design process. The basic design of the 5.0 GHz LHCD launcher (coupler) has been finished using the HFSS and ANSYS programs.

  1. Development of Production Systems

    Christiansen, Thomas Bøhm

    This paper presents the initial considerations related to a Ph.D. study initiated at IPV, DTU in February 1997, concerning the research subject "Development of Production Systems". The content and aim of this paper is to 1) to introduce the study by......This paper presents the initial considerations related to a Ph.D. study initiated at IPV, DTU in February 1997, concerning the research subject "Development of Production Systems". The content and aim of this paper is to 1) to introduce the study by...

  2. RSMASS system model development

    RSMASS system mass models have been used for more than a decade to make rapid estimates of space reactor power system masses. This paper reviews the evolution of the RSMASS models and summarizes present capabilities. RSMASS has evolved from a simple model used to make rough estimates of space reactor and shield masses to a versatile space reactor power system model. RSMASS uses unique reactor and shield models that permit rapid mass optimization calculations for a variety of space reactor power and propulsion systems. The RSMASS-D upgrade of the original model includes algorithms for the balance of the power system, a number of reactor and shield modeling improvements, and an automatic mass optimization scheme. The RSMASS-D suite of codes cover a very broad range of reactor and power conversion system options as well as propulsion and bimodal reactor systems. Reactor choices include in-core and ex-core thermionic reactors, liquid metal cooled reactors, particle bed reactors, and prismatic configuration reactors. Power conversion options include thermoelectric, thermionic, Stirling, Brayton, and Rankine approaches. Program output includes all major component masses and dimensions, efficiencies, and a description of the design parameters for a mass optimized system. In the past, RSMASS has been used as an aid to identify and select promising concepts for space power applications. The RSMASS modeling approach has been demonstrated to be a valuable tool for guiding optimization of the power system design; consequently, the model is useful during system design and development as well as during the selection process. An improved in-core thermionic reactor system model RSMASS-T is now under development. The current development of the RSMASS-T code represents the next evolutionary stage of the RSMASS models. RSMASS-T includes many modeling improvements and is planned to be more user-friendly. RSMASS-T will be released as a fully documented, certified code at the end of 1998. A radioisotope space power system model RISMASS is also under development. RISMASS will optimize and predict system masses for radioisotope power sources coupled with close-spaced thermionic diodes. Although RSMASS-D models have been developed for a broad variety of space nuclear power and propulsion systems, only a few concepts will be included in the releasable RSMASS-T computer code. A follow-on effort is recommended to incorporate all previous models as well as solar power system models into one general code. The proposed Space Power and propulsion system MASS (SPMASS) code would provide a consistent analysis tool for comparing a very broad range of alternative power and propulsion systems for any required power level and operating conditions. As for RSMASS-T the SPMASS model should be a certified, fully documented computer code available for general use. The proposed computer program would provide space mission planners with the capability to quickly and cost effectively explore power system options for any space mission. The code should be applicable for power requirements from as low as a few milliwatts (solar and isotopic system options) to many megawatts for reactor power and propulsion systems

  3. An MPS-BNS mixed strategy based on game theory for wireless mesh networks.

    Huang, S Q; Wang, G C; Zhen, H H; Zhang, Z

    2013-01-01

    To achieve a valid effect of wireless mesh networks against selfish nodes and selfish behaviors in the packets forwarding, an approach named mixed MPS-BNS strategy is proposed in this paper. The proposed strategy is based on the Maximum Payoff Strategy (MPS) and the Best Neighbor Strategy (BNS). In this strategy, every node plays a packet forwarding game with its neighbors and records the total payoff of the game. After one round of play, each player chooses the MPS or BNS strategy for certain probabilities and updates the strategy accordingly. In MPS strategy, each node chooses a strategy that will get the maximum payoff according to its neighbor's strategy. In BNS strategy, each node follows the strategy of its neighbor with the maximum total payoff and then enters the next round of play. The simulation analysis has shown that MPS-BNS strategy is able to evolve to the maximum expected level of average payoff with faster speed than the pure BNS strategy, especially in the packets forwarding beginning with a low cooperation level. It is concluded that MPS-BNS strategy is effective in fighting against selfishness in different levels and can achieve a preferable performance. PMID:23401672

  4. Experiments and MPS analysis of stratification behavior of two immiscible fluids

    Highlights: • Improving numerical stability of MPS method. • Implicitly calculating viscous term in momentum equation for highly viscous fluids. • Validation of the enhanced MPS method by analyzing dam break problem. • Various stratification behavior analysis by experiments and simulations. • Sensitivity analysis of the effects of the fluid viscosity and density difference. - Abstract: Stratification behavior is of great significance in the late in-vessel stage of core melt severe accident of a nuclear reactor. Conventional numerical methods have difficulties in analyzing stratification process accompanying with free surface without depending on empirical correlations. The Moving Particle Semi-implicit (MPS) method, which calculates free surface and multiphase flow without empirical equations, is applicable for analyzing the stratification behavior of fluids. In the present study, the original MPS method was improved to simulate the stratification behavior of two immiscible fluids. The improved MPS method was validated through simulating classical dam break problem. Then, the stratification processes of two fluid columns and injected fluid were investigated through experiments and simulations, using silicone oil and salt water as the simulant materials. The effects of fluid viscosity and density difference on stratification behavior were also sensitively investigated by simulations. Typical fluid configurations at various parametric and geometrical conditions were observed and well predicted by improved MPS method

  5. A DSP-Based Beam Current Monitoring System for Machine Protection Using Adaptive Filtering

    The CEBAF accelerator at Jefferson Lab is currently using an analog beam current monitoring (BCM) system for its machine protection system (MPS), which has a loss accuracy of 2 micro-amps. Recent burn-through simulations predict catastrophic beam line component failures below 1 micro-amp of loss, resulting in a blind spot for the MPS. Revised MPS requirements target an ultimate beam loss accuracy of 250 nA. A new beam current monitoring system has been developed which utilizes modern digital receiver technology and digital signal processing concepts. The receiver employs a direct-digital down converter integrated circuit, mated with a Jefferson Lab digital signal processor VME card. Adaptive filtering is used to take advantage of current-dependent burn-through rates. Benefits of such a system include elimination of DC offsets, generic algorithm development, extensive filter options, and interfaces to UNIX-based control systems

  6. Myocardial Perfusion Tomoscintigraphy With 99mTc MIBI (SPECT MPS 99mTc MIBI) In The Assessment Of Myocardial Viability

    Prognosis of the patients with severe coronary artery disease is highly dependent on the degree of left ventricular dysfunction. Impaired contractile performance at rest is not necessarily due to Irreversible tissue damage but may relate to the 'hibernating' myocardium which has been defined as potentially reversible, chronic contractile dysfunction during prolonged, painless ischemia. Recovery of function may occur after successful revascularization only in the presence of substantial amount of viable myocardium. The development of highly precise and predictable diagnostic methods for the identification of viable myocardium and postoperative functional improvement is crucial for reasonable preoperative selection of the patients. Detection of hibernated myocardium Is a real diagnostic challenge when FDG-Fl8 PET, as the most accurate method for myocardial viability assessment is not available and Tl 201, as already established myocardial viability marker is not routinely used. Interest for the 99mTc labeled complexes, most often 99mTc MIBI, as proved myocardial perfusion but not yet viability tracer is constantly increasing, supported by the widespread availability of this radioisotope, its better imaging and radio dosimetric properties when compared to Ti 201. The aim of this study was to evaluate the diagnostic value of different SPECT MIBI Tc99m myocardial perfusion scintigraphy (MPS) modalities performed at rest and after nitrate administration, in the detection of myocardial viability (MV) arid to compare it with rest-redistribution TI 201 MPS (R-Red) and with the control SPECT MPS Tc99m MIBI study after revascularization. In a prospective study, 176 patients (34-77yrs, 25 female, 151 male), with angiographically proved coronary artery disease, most of them with previous myocardial infarction (143/176p (81%),>6 months) and LV dysfunction (110/176p (62%), EFG-MPS 41+/-16%) underwent ECG Gated SPECT MPS Tc 99m MIBI at rest and after s.l. administration of 0,5 mg Nitroglycerin (NTG). 20/176 p were examined also by TI 201 R-Red study and 20/176p were reevaluated after revascularization. Qualitative and quantitative analysis of rest, post-NTG and TI 201 Rest-Redistribution perfusion images (QL,QN) and functional analysis of rest and post-NTG Gated study (G) was done, using 17 segment model, grouped also according to vascular territories and 5-point scoring system for assessment of perfusion (0-normal, 1-mild,2-moderate,3-severe hypoperfusion, 4-absent perfusion) and wall motion (0-normal,l-mild,2-severe hypo kinetic, 3-akinetic,4-dyskinetic). A segment was predeterminated to be viable if the segment score was ?2 by perfusion (>50% photon activity by circumferential profiles) and ?2 by C-CG qated SPECT analysis (wall motion +/-, wall thickening-). Summed segment viability scores, total and separate for particular territory were. calculated and used to predict overall and territory viability. In a group of 176 pts, from a total of 2992 analyzed myocardial segments, 47% were nonviable by QL-Rest analysis, 31% by QN-Rest (p2) 25% by G-Rest (p2), 36% by QL-Rest-Red (p=0.3 vs. QL-Rest, ?2), 18% by QN-Rest-Red (p=04 vs. QN-Rest, ?2),), 33% by QL-NTG (p2), 19% by QN-NTG (p2), 16% by G-NTG (p=0.08 vs. QN-NTG, ?2), 28% by QL-NTG-Red (P=0.33 vs. QL-NTG, ?2), and 17% by QN-NTG-Red (p=0.4 vs. QN- NTG, ?2). Similar relation among different modalities was also observed during the assessment of total viability score: 26+/-9.1 by QN-Rest, 21.8+/-8.9 by G-Rest (p<0.01 vs. QN-Rest), 20.2+/-9.9 by QN-NTG (p<0.0l vs. G-Rest) and 16.7+/-9.4 by NTG-G (p<0.001 vs QN-NTG). Compared with TI 201 R-Red the sensitivity, specificity, positive and negative predictive values and accuracy for SPECT MPS Tc99m MIBI modalities were: 73%,100%,100%,37,5%,76% for QL-Rest, 84%,96%,99%,49%,86% for QN-Rest, 93,5%,81%,97%,67% 92% for G-Rest, 86%,94%, 99%,52%,87% for QL-NTG, 97%,90%,98%,81%,96% for QN-NTG and 97%,75%,96%82%,94% for G-NTG. Compared with the study after revascularization the sensitivity, specificity, positive and negative predictive values a

  7. Requirement for human Mps1/TTK in oxidative DNA damage repair and cell survival through MDM2 phosphorylation.

    Yu, Zheng-Cheng; Huang, Yi-Fu; Shieh, Sheau-Yann

    2016-02-18

    Human Mps1 (hMps1) is a protein kinase essential for mitotic checkpoints and the DNA damage response. Here, we present new evidence that hMps1 also participates in the repair of oxidative DNA lesions and cell survival through the MDM2-H2B axis. In response to oxidative stress, hMps1 phosphorylates MDM2, which in turn promotes histone H2B ubiquitination and chromatin decompaction. These events facilitate oxidative DNA damage repair and ATR-CHK1, but not ATM-CHK2 signaling. Depletion of hMps1 or MDM2 compromised H2B ubiquitination, DNA repair and cell survival. The impairment could be rescued by re-expression of WT but not the phospho-deficient MDM2 mutant, supporting the involvement of hMps1-dependent MDM2 phosphorylation in the oxidative stress response. In line with these findings, localization of RPA and base excision repair proteins to damage foci also requires MDM2 and hMps1. Significantly, like MDM2, hMps1 is upregulated in human sarcoma, suggesting high hMps1 and MDM2 expression may be beneficial for tumors constantly challenged by an oxidative micro-environment. Our study therefore identified an hMps1-MDM2-H2B signaling axis that likely plays a relevant role in tumor progression. PMID:26531827

  8. The prognosis of myofascial pain syndrome (MPS) during a fixed orthodontic treatment.

    Tecco, Simona; Marzo, Giuseppe; Crincoli, Vito; Di Bisceglie, Beatrice; Tetè, Stefano; Festa, Felice

    2012-01-01

    Among treatments in the literature for myofascial pain syndrome (MPS), the most reliable therapies in dentistry are spray and stretch, and, although less frequently used, anesthetic injection. Adult MPS subjects are often treated using fixed orthodontic therapy for resolution of malocclusion. There is no clarity in the literature on the prognosis of MPS during orthodontic therapy. The purpose of this study was to analyze the prognosis of MPS during orthodontic treatment of subjects with malocclusion, initially diagnosed as having MPS. The analysis covered the medical records of 91 young adult Caucasians scheduled for orthodontic treatment for various malocclusions. Thirty-seven of the patients were initially diagnosed as also having MPS (T0). Thirty patients began the orthodontic treatment and were recalled for a re-evaluation of MPS after dental alignment and dental class correction was achieved (T1). A wait-and-see strategy was applied in seven subjects who were included as the control subjects. They received no treatment for MPS. At T1, a statistically significant decrease was observed in the study group in the presence of any clicking or creaking noises from the jaw joint, a significant jaw joint and jaw muscle pain reduction, and a quality of life improvement. Among patients who were depressed at the beginning of treatment, the majority felt better at the follow-up evaluation. On muscular palpation, a statistically significant decrease was found on the visual analogic scale value of the middle fibers of the temporalis muscle, temporalis tendon, clavicular and sternal division of the sternocleidomastoid muscle, masseter muscles, and posterior cervical muscles. The temporalis and the masseter muscles showed a significant decrease in the number of subjects with trigger points (TrPs) in all areas in the study group, after treatment. The digastric and sternocleidomastoid muscles also showed a significant reduction in the number of subjects with TrPs. Subjects with MPS and malocclusion were treated using a fixed orthodontic treatment. They showed improvement, although no resolution, in the signs and symptoms of MPS, compared with the untreated control group. PMID:22435177

  9. A structured light sensor measuring method based on wMPS global controlling

    Chen, Yang; Lin, Jiarui; Guo, Yin; Gao, Yang; Yang, Shourui

    2015-10-01

    In large-scale three-dimensional (3D) coordinates measurement, to solve the problem of structured light sensor's measurement data from different measurement stations unifying to the global coordinate system, a method based on workshop Measuring Position System (wMPS) global controlling is researched to concentrate the structured light sensor's measurement data to the global coordinate system automatically. According to the measurement principle, two calibration methods are proposed to calibrate the structural parameters based on a standard ball, one is transferring stations based on common points and the other is fitting ball equation. Finally, a platform for experiment is built to verify the two calibration methods. Experimental results show that the average measurement error on 10 points is 0.127 mm according to the laser tracker of the first method and the other average error is 0.101 mm, both the two calibration methods have a high precision to meet the demands of large-scale 3D coordinates measurement.

  10. Assessment of dysmyelination with RAFFn MRI: application to murine MPS I.

    Satzer, David; DiBartolomeo, Christina; Ritchie, Michael M; Storino, Christine; Liimatainen, Timo; Hakkarainen, Hanne; Idiyatullin, Djaudat; Mangia, Silvia; Michaeli, Shalom; Parr, Ann M; Low, Walter C

    2015-01-01

    Type I mucopolysaccharidosis (MPS I) is an autosomal recessive lysosomal storage disorder with neurological features. Humans and laboratory animals with MPS I exhibit various white matter abnormalities involving the corpus callosum and other regions. In this study, we first validated a novel MRI technique, entitled Relaxation Along a Fictitious Field in the rotating frame of rank n (RAFFn), as a measure of myelination and dysmyelination in mice. We then examined differences between MPS I mice and heterozygotes using RAFF5 and histology. RAFF5 (i.e., RAFFn with n = 5) relaxation time constants were highly correlated with histological myelin density (R2 = 0.68, P<0.001), and RAFF5 clearly distinguished between the hypomyelinated and dysmyelinated shiverer mouse and the wild-type mouse. Bloch-McConnell theoretical analysis revealed slower exchange correlation times and smaller exchange-induced relaxation rate constants for RAFF4 and RAFF5 compared to RAFF1-3, T1ρ, and T2ρ. These data suggest that RAFF5 may assess methylene protons in myelin lipids and proteins, though other mechanisms (e.g. detection of myelin-bound water) may also explain the sensitivity of RAFF5 to myelin. In MPS I mice, mean RAFF5 relaxation time constants were significantly larger for the striatum (P = 0.004) and internal capsule (P = 0.039), and marginally larger for the fornix (P = 0.15). Histological assessment revealed no differences between MPS I mice and heterozygotes in myelin density or corpus callosum thickness. Taken together, these findings support subtle dysmyelination in the brains of mice with MPS I. Dysmyelination may result from myelin lipid abnormalities caused by the absence of α-L-iduronidase. Our findings may help to explain locomotor and cognitive deficits seen in mice with MPS I. PMID:25680196

  11. Assessment of Dysmyelination with RAFFn MRI: Application to Murine MPS I

    Satzer, David; DiBartolomeo, Christina; Ritchie, Michael M.; Storino, Christine; Liimatainen, Timo; Hakkarainen, Hanne; Idiyatullin, Djaudat; Mangia, Silvia; Michaeli, Shalom; Parr, Ann M.; Low, Walter C.

    2015-01-01

    Type I mucopolysaccharidosis (MPS I) is an autosomal recessive lysosomal storage disorder with neurological features. Humans and laboratory animals with MPS I exhibit various white matter abnormalities involving the corpus callosum and other regions. In this study, we first validated a novel MRI technique, entitled Relaxation Along a Fictitious Field in the rotating frame of rank n (RAFFn), as a measure of myelination and dysmyelination in mice. We then examined differences between MPS I mice and heterozygotes using RAFF5 and histology. RAFF5 (i.e., RAFFn with n = 5) relaxation time constants were highly correlated with histological myelin density (R2 = 0.68, P<0.001), and RAFF5 clearly distinguished between the hypomyelinated and dysmyelinated shiverer mouse and the wild-type mouse. Bloch-McConnell theoretical analysis revealed slower exchange correlation times and smaller exchange-induced relaxation rate constants for RAFF4 and RAFF5 compared to RAFF1-3, T1ρ, and T2ρ. These data suggest that RAFF5 may assess methylene protons in myelin lipids and proteins, though other mechanisms (e.g. detection of myelin-bound water) may also explain the sensitivity of RAFF5 to myelin. In MPS I mice, mean RAFF5 relaxation time constants were significantly larger for the striatum (P = 0.004) and internal capsule (P = 0.039), and marginally larger for the fornix (P = 0.15). Histological assessment revealed no differences between MPS I mice and heterozygotes in myelin density or corpus callosum thickness. Taken together, these findings support subtle dysmyelination in the brains of mice with MPS I. Dysmyelination may result from myelin lipid abnormalities caused by the absence of α-L-iduronidase. Our findings may help to explain locomotor and cognitive deficits seen in mice with MPS I. PMID:25680196

  12. CheMPS2: a free open-source spin-adapted implementation of the density matrix renormalization group for ab initio quantum chemistry

    Wouters, Sebastian; Ayers, Paul W; Van Neck, Dimitri

    2013-01-01

    The density matrix renormalization group (DMRG) has become an indispensable numerical tool to find exact eigenstates of finite-size quantum systems with strong correlation. In the fields of condensed matter, nuclear structure and molecular electronic structure, it has significantly extended the system sizes that can be handled compared to full configuration interaction, without losing numerical accuracy. For quantum chemistry (QC), the most efficient implementations of DMRG require the incorporation of particle number, spin and point group symmetries in the underlying matrix product state (MPS) ansatz, as well as the use of so-called complementary operators. The symmetries introduce a sparse block structure in the MPS ansatz and in the intermediary contracted tensors. If a symmetry is non-abelian, the Wigner-Eckart theorem allows to factorize a tensor into a Clebsch-Gordan coefficient and a reduced tensor. In addition, the fermion signs have to be carefully tracked. Because of these challenges, implementing D...

  13. Geological disposal system development

    Kang, Chul Hyung; Kuh, J. E.; Kim, S. K. and others

    2000-04-01

    Spent fuel inventories to be disposed of finally and design base spent fuel were determined. Technical and safety criteria for a geological repository system in Korea were established. Based on the properties of spent PWR and CANDU fuels, seven repository alternatives were developed and the most promising repository option was selected by the pair-wise comparison method from the technology point of view. With this option preliminary conceptual design studies were carried out. Several module, e.g., gap module, congruent release module were developed for the overall assessment code MASCOT-K. The prominent overseas databases such as OECD/NEA FEP list were are fully reviewed and then screened to identify the feasible ones to reflect the Korean geo-hydrological conditions. In addition to this the well known scenario development methods such as PID, RES were reviewed. To confirm the radiological safety of the proposed KAERI repository concept the preliminary PA was pursued. Thermo-hydro-mechanical analysis for the near field of repository were performed to verify thermal and mechanical stability for KAERI repository system. The requirements of buffer material were analyzed, and based on the results, the quantitative functional criteria for buffer material were established. The hydraulic and swelling property, mechanical properties, and thermal conductivity, the organic carbon content, and the evolution of pore water chemistry were investigated. Based on the results, the candidate buffer material was selected.

  14. Geological disposal system development

    Spent fuel inventories to be disposed of finally and design base spent fuel were determined. Technical and safety criteria for a geological repository system in Korea were established. Based on the properties of spent PWR and CANDU fuels, seven repository alternatives were developed and the most promising repository option was selected by the pair-wise comparison method from the technology point of view. With this option preliminary conceptual design studies were carried out. Several module, e.g., gap module, congruent release module were developed for the overall assessment code MASCOT-K. The prominent overseas databases such as OECD/NEA FEP list were are fully reviewed and then screened to identify the feasible ones to reflect the Korean geo-hydrological conditions. In addition to this the well known scenario development methods such as PID, RES were reviewed. To confirm the radiological safety of the proposed KAERI repository concept the preliminary PA was pursued. Thermo-hydro-mechanical analysis for the near field of repository were performed to verify thermal and mechanical stability for KAERI repository system. The requirements of buffer material were analyzed, and based on the results, the quantitative functional criteria for buffer material were established. The hydraulic and swelling property, mechanical properties, and thermal conductivity, the organic carbon content, and the evolution of pore water chemistry were investigated. Based on the results, the candidate buffer material was selected

  15. Numerical analysis of crust formation in molten core-concrete interaction using MPS method

    A two-dimensional code is developed for molten core-concrete interaction (MCCI) based on Moving Particle Semi-implicit (MPS) method. Heat transfer is calculated without any specific correlations. A particle can be changed to a moving (fluid) or fixed (solid) particle corresponding to its enthalpy, which provide the phase change model for particles. The phase change model is verified by one-dimensional test calculations. Nucleate boiling and radiation heat transfers are considered between the core debris and the water pool. The developed code is applied to SWISS-2 experiment in which stainless steel is used as the melt material. Calculated heat flux to the water pool agrees well with the experiment, though the ablation speed in the concrete is a little slower. A stable crust is formed in a short time after water is poured in and the heat flux to the water pool rapidly decreases. MACE-M0 using corium is also analyzed. The ablation speed of concrete is slower than that of SWISS-2 because of low heat conduction in corium. An unlimited geometry is analyzed by setting the cyclic boundary condition on the sides. When the crust is broken by the decomposition gas, heat transfer to the water pool is kept high for a longer time because the crust re-formation is delayed. (author)

  16. Sepsis and development impede muscle protein synthesis in neonatal pigs by different ribosomal mechanisms

    In muscle, sepsis reduces protein synthesis (MPS) by restraining translation in neonates and adults. Even though protein accretion decreases with development as neonatal MPS rapidly declines by maturation, the changes imposed by development on the sepsis-associated decrease in MPS have not been desc...

  17. Power Systems Development Facility

    The objective of the PSDF would be to provide a modular facility which would support the development of advanced, pilot-scale, coal-based power systems and hot gas clean-up components. These pilot-scale components would be designed to be large enough so that the results can be related and projected to commercial systems. The facility would use a modular approach to enhance the flexibility and capability for testing; consequently, overall capital and operating costs when compared with stand-alone facilities would be reduced by sharing resources common to different modules. The facility would identify and resolve technical barrier, as well as-provide a structure for long-term testing and performance assessment. It is also intended that the facility would evaluate the operational and performance characteristics of the advanced power systems with both bituminous and subbituminous coals. Five technology-based experimental modules are proposed for the PSDF: (1) an advanced gasifier module, (2) a fuel cell test module, (3) a PFBC module, (4) a combustion gas turbine module, and (5) a module comprised of five hot gas cleanup particulate control devices. The final module, the PCD, would capture coal-derived ash and particles from both the PFBC and advanced gasifier gas streams to provide for overall particulate emission control, as well as to protect the combustion turbine and the fuel cell

  18. Power Systems Development Facility

    None

    2003-07-01

    This report discusses Test Campaign TC12 of the Kellogg Brown & Root, Inc. (KBR) Transport Gasifier train with a Siemens Westinghouse Power Corporation (SW) particle filter system at the Power Systems Development Facility (PSDF) located in Wilsonville, Alabama. The Transport Gasifier is an advanced circulating fluidized-bed reactor designed to operate as either a combustor or a gasifier using a particulate control device (PCD). While operating as a gasifier, either air or oxygen can be used as the oxidant. Test run TC12 began on May 16, 2003, with the startup of the main air compressor and the lighting of the gasifier start-up burner. The Transport Gasifier operated until May 24, 2003, when a scheduled outage occurred to allow maintenance crews to install the fuel cell test unit and modify the gas clean-up system. On June 18, 2003, the test run resumed when operations relit the start-up burner, and testing continued until the scheduled end of the run on July 14, 2003. TC12 had a total of 733 hours using Powder River Basin (PRB) subbituminous coal. Over the course of the entire test run, gasifier temperatures varied between 1,675 and 1,850 F at pressures from 130 to 210 psig.

  19. Advanced Dewatering Systems Development

    R.H. Yoon; G.H. Luttrell

    2008-07-31

    A new fine coal dewatering technology has been developed and tested in the present work. The work was funded by the Solid Fuels and Feedstocks Grand Challenge PRDA. The objective of this program was to 'develop innovative technical approaches to ensure a continued supply of environmentally sound solid fuels for existing and future combustion systems with minimal incremental fuel cost.' Specifically, this solicitation is aimed at developing technologies that can (i) improve the efficiency or economics of the recovery of carbon when beneficiating fine coal from both current production and existing coal slurry impoundments and (ii) assist in the greater utilization of coal fines by improving the handling characteristics of fine coal via dewatering and/or reconstitution. The results of the test work conducted during Phase I of the current project demonstrated that the new dewatering technologies can substantially reduce the moisture from fine coal, while the test work conducted during Phase II successfully demonstrated the commercial viability of this technology. It is believed that availability of such efficient and affordable dewatering technology is essential to meeting the DOE's objectives.

  20. Computational haemodynamics of small vessels using the Moving Particle Semi-implicit (MPS) method

    Gambaruto, Alberto M.

    2015-12-01

    The simulation of whole blood stands as a complex multi-body problem. The Moving Particle Semi-implicit method, a Lagrangian particle method to solve the incompressible Navier-Stokes (NS) equations, is developed to perform simulations in complex periodic domains. Red blood cells are modelled using the spring network approach, that act as body force terms in the NS equations. Detailed presentation and derivation of both the MPS method and different spring network models is given. An adaptive time step and an implicit scheme are adopted, improving the stability and overall computational efficiency. The findings from the simulations show evidence that in proximity to the vessel wall, the red blood cells expose a larger surface area by orientation and deformation, due to the presence of a high velocity gradient. The greatest membrane internal stresses occur in the core region of the flow. The intra-cell interaction is driven by a complex flow field that can be visualised in a Lagrangian framework, and highlights vortex structures in the wakes and in between the cells. The stresses the blood exerts on the vessel wall are influenced by this complex flow field and by the presence of red blood cells.

  1. ARHGEF17 is an essential spindle assembly checkpoint factor that targets Mps1 to kinetochores.

    Isokane, Mayumi; Walter, Thomas; Mahen, Robert; Nijmeijer, Bianca; Hériché, Jean-Karim; Miura, Kota; Maffini, Stefano; Ivanov, Miroslav Penchev; Kitajima, Tomoya S; Peters, Jan-Michael; Ellenberg, Jan

    2016-03-14

    To prevent genome instability, mitotic exit is delayed until all chromosomes are properly attached to the mitotic spindle by the spindle assembly checkpoint (SAC). In this study, we characterized the function of ARHGEF17, identified in a genome-wide RNA interference screen for human mitosis genes. Through a series of quantitative imaging, biochemical, and biophysical experiments, we showed that ARHGEF17 is essential for SAC activity, because it is the major targeting factor that controls localization of the checkpoint kinase Mps1 to the kinetochore. This mitotic function is mediated by direct interaction of the central domain of ARHGEF17 with Mps1, which is autoregulated by the activity of Mps1 kinase, for which ARHGEF17 is a substrate. This mitosis-specific role is independent of ARHGEF17's RhoGEF activity in interphase. Our study thus assigns a new mitotic function to ARHGEF17 and reveals the molecular mechanism for a key step in SAC establishment. PMID:26953350

  2. Power Systems Development Facility

    Southern Company Services

    2004-04-30

    This report discusses Test Campaign TC15 of the Kellogg Brown & Root, Inc. (KBR) Transport Gasifier train with a Siemens Power Generation, Inc. (SPG) particle filter system at the Power Systems Development Facility (PSDF) located in Wilsonville, Alabama. The Transport Gasifier is an advanced circulating fluidized-bed reactor designed to operate as either a combustor or gasifier using a particulate control device (PCD). While operating as a gasifier, either air or oxygen can be used as the oxidant. Test run TC15 began on April 19, 2004, with the startup of the main air compressor and the lighting of the gasifier startup burner. The Transport Gasifier was shutdown on April 29, 2004, accumulating 200 hours of operation using Powder River Basin (PRB) subbituminous coal. About 91 hours of the test run occurred during oxygen-blown operations. Another 6 hours of the test run was in enriched-air mode. The remainder of the test run, approximately 103 hours, took place during air-blown operations. The highest operating temperature in the gasifier mixing zone mostly varied from 1,800 to 1,850 F. The gasifier exit pressure ran between 200 and 230 psig during air-blown operations and between 110 and 150 psig in oxygen-enhanced air operations.

  3. POWER SYSTEMS DEVELOPMENT FACILITY

    Unknown

    2002-11-01

    This report discusses test campaign GCT4 of the Kellogg Brown & Root, Inc. (KBR) transport reactor train with a Siemens Westinghouse Power Corporation (Siemens Westinghouse) particle filter system at the Power Systems Development Facility (PSDF) located in Wilsonville, Alabama. The transport reactor is an advanced circulating fluidized-bed reactor designed to operate as either a combustor or a gasifier using one of two possible particulate control devices (PCDs). The transport reactor was operated as a pressurized gasifier during GCT4. GCT4 was planned as a 250-hour test run to continue characterization of the transport reactor using a blend of several Powder River Basin (PRB) coals and Bucyrus limestone from Ohio. The primary test objectives were: Operational Stability--Characterize reactor loop and PCD operations with short-term tests by varying coal-feed rate, air/coal ratio, riser velocity, solids-circulation rate, system pressure, and air distribution. Secondary objectives included the following: Reactor Operations--Study the devolatilization and tar cracking effects from transient conditions during transition from start-up burner to coal. Evaluate the effect of process operations on heat release, heat transfer, and accelerated fuel particle heat-up rates. Study the effect of changes in reactor conditions on transient temperature profiles, pressure balance, and product gas composition. Effects of Reactor Conditions on Synthesis Gas Composition--Evaluate the effect of air distribution, steam/coal ratio, solids-circulation rate, and reactor temperature on CO/CO{sub 2} ratio, synthesis gas Lower Heating Value (LHV), carbon conversion, and cold and hot gas efficiencies. Research Triangle Institute (RTI) Direct Sulfur Recovery Process (DSRP) Testing--Provide syngas in support of the DSRP commissioning. Loop Seal Operations--Optimize loop seal operations and investigate increases to previously achieved maximum solids-circulation rate.

  4. Decreased lysosomal storage in the adult MPS VII mouse brain in the vicinity of grafts of retroviral vector-corrected fibroblasts secreting high levels of beta-glucuronidase.

    Taylor, R M; Wolfe, J H

    1997-07-01

    A deficiency of beta-glucuronidase (GUSB) causes the multisystem progressive degenerative syndrome, mucopolysaccharidosis (MPS) type VII (Sly disease), which includes mental retardation. Animal homologues of MPS VII (ref. 3, 4) are models for testing somatic gene transfer approaches to treat the central nervous system in this and other lysosomal storage disorders. Previous attempts to correct murine MPS VII by gene therapy have successfully treated lesions in some organs but not in the brain. Other experimental modalities have forestalled some disease progression in the brain, but only if done at birth, before the onset of severe lesions, when the animals are phenotypically normal. We tested whether therapeutic amounts of GUSB could be delivered to the diseased adult brain by transplanting cells engineered to super-secrete the normal enzyme for export to surrounding neural tissues. Lysosomal distention was cleared from neurons and glial cells in the vicinity of the grafts, showing that the secreted enzyme could reach the diseased cells and reverse lesions in the severely diseased brain. The ability to correct established lesions will be important for the treatment of many lysosomal storage diseases affecting the brain, because most patients are not diagnosed until lesions are advanced enough to affect phenotype or developmental milestones in early childhood, and some forms of the diseases do not become apparent until later in life. PMID:9212105

  5. Mps1Mph1 Kinase Phosphorylates Mad3 to Inhibit Cdc20Slp1-APC/C and Maintain Spindle Checkpoint Arrests.

    Zich, Judith; May, Karen; Paraskevopoulos, Konstantinos; Sen, Onur; Syred, Heather M; van der Sar, Sjaak; Patel, Hitesh; Moresco, James J; Sarkeshik, Ali; Yates, John R; Rappsilber, Juri; Hardwick, Kevin G

    2016-02-01

    The spindle checkpoint is a mitotic surveillance system which ensures equal segregation of sister chromatids. It delays anaphase onset by inhibiting the action of the E3 ubiquitin ligase known as the anaphase promoting complex or cyclosome (APC/C). Mad3/BubR1 is a key component of the mitotic checkpoint complex (MCC) which binds and inhibits the APC/C early in mitosis. Mps1Mph1 kinase is critical for checkpoint signalling and MCC-APC/C inhibition, yet few substrates have been identified. Here we identify Mad3 as a substrate of fission yeast Mps1Mph1 kinase. We map and mutate phosphorylation sites in Mad3, producing mutants that are targeted to kinetochores and assembled into MCC, yet display reduced APC/C binding and are unable to maintain checkpoint arrests. We show biochemically that Mad3 phospho-mimics are potent APC/C inhibitors in vitro, demonstrating that Mad3p modification can directly influence Cdc20Slp1-APC/C activity. This genetic dissection of APC/C inhibition demonstrates that Mps1Mph1 kinase-dependent modifications of Mad3 and Mad2 act in a concerted manner to maintain spindle checkpoint arrests. PMID:26882497

  6. Bone marrow transplantation in patients with storage diseases: a developing country experience

    Lange Marcos C.

    2006-01-01

    Full Text Available Bone marrow transplantation (BMT is a therapeutic option for patients with genetic storage diseases. Between 1979 and 2002, eight patients, four females and four males (1 to 13 years old were submitted to this procedure in our center. Six patients had mucopolysaccharidosis (MPS I in 3; MPS III in one and MPS VI in 2, one had adrenoleukodystrophy (ALD and one had Gaucher disease. Five patients had related and three unrelated BMT donor. Three patients developed graft versus host disease (two MPS I and one MPS VI and died between 37 and 151 days after transplantation. Five patients survived 4 to 16 years after transplantation. Three patients improved (one MPS I; one MPS VI and the Gaucher disease patient, one patient had no disease progression (ALD and in one patient this procedure did not change the natural course of the disease (MPS III.

  7. Circulating microparticles and plasma levels of soluble E- and P-selectins in patients with systemic sclerosis

    Iversen, Lars; Østergaard, O; Ullman, S; Nielsen, C T; Halberg, P; Karlsmark, T; Heegaard, Niels Henrik Helweg; Jacobsen, Søren

    2013-01-01

    Microparticles (MPs) may be involved in the pathogenesis of systemic sclerosis (SSc), which includes vasculopathy, endothelial cell activation, and coagulation activation. Circulating MPs from SSc patients were characterized and their relationship with soluble markers of vascular activation inves...

  8. Development of two-dimensional position sensitive detector systems using multi-pixel photon counters for neutron experiments

    Satoh, Setsuo, E-mail: setsuo.satoh@kek.jp; Muto, Suguru

    2013-12-11

    Neutron scattering experiments are indispensable to the structural analysis of many types of condensed matter and in the development of advanced materials. A high resolution detector system and a high counting rate detector system, both utilizing a neutron scintillator and multi-pixel photon counters (MPPCs), have been developed at the High-Energy Accelerator Research Organization (KEK). These systems will be used in the BL16 and BL06 neutron scattering instruments at the Material and Life Science Facility (MLF) in the Japan Proton Accelerator Research Complex (J-PARC). The high resolution detector is an MPPC position-sensitive detector (MPS) with a 105128 mm{sup 2} detection area and has positional resolution of 1 mm. The high counting rate detector is an MPPC Pixel detector (MPIX) with a 32040 mm{sup 2} detection area. The maximum counting rate is 4 million counts per second (Mcps)

  9. Development of two-dimensional position sensitive detector systems using multi-pixel photon counters for neutron experiments

    Neutron scattering experiments are indispensable to the structural analysis of many types of condensed matter and in the development of advanced materials. A high resolution detector system and a high counting rate detector system, both utilizing a neutron scintillator and multi-pixel photon counters (MPPCs), have been developed at the High-Energy Accelerator Research Organization (KEK). These systems will be used in the BL16 and BL06 neutron scattering instruments at the Material and Life Science Facility (MLF) in the Japan Proton Accelerator Research Complex (J-PARC). The high resolution detector is an MPPC position-sensitive detector (MPS) with a 105128 mm2 detection area and has positional resolution of 1 mm. The high counting rate detector is an MPPC Pixel detector (MPIX) with a 32040 mm2 detection area. The maximum counting rate is 4 million counts per second (Mcps)

  10. POWER SYSTEMS DEVELOPMENT FACILITY

    Unknown

    2002-05-01

    This report discusses test campaign GCT3 of the Halliburton KBR transport reactor train with a Siemens Westinghouse Power Corporation (Siemens Westinghouse) particle filter system at the Power Systems Development Facility (PSDF) located in Wilsonville, Alabama. The transport reactor is an advanced circulating fluidized-bed reactor designed to operate as either a combustor or a gasifier using one of two possible particulate control devices (PCDs). The transport reactor was operated as a pressurized gasifier during GCT3. GCT3 was planned as a 250-hour test run to commission the loop seal and continue the characterization of the limits of operational parameter variations using a blend of several Powder River Basin coals and Bucyrus limestone from Ohio. The primary test objectives were: (1) Loop Seal Commissioning--Evaluate the operational stability of the loop seal with sand and limestone as a bed material at different solids circulation rates and establish a maximum solids circulation rate through the loop seal with the inert bed. (2) Loop Seal Operations--Evaluate the loop seal operational stability during coal feed operations and establish maximum solids circulation rate. Secondary objectives included the continuation of reactor characterization, including: (1) Operational Stability--Characterize the reactor loop and PCD operations with short-term tests by varying coal feed, air/coal ratio, riser velocity, solids circulation rate, system pressure, and air distribution. (2) Reactor Operations--Study the devolatilization and tar cracking effects from transient conditions during transition from start-up burner to coal. Evaluate the effect of process operations on heat release, heat transfer, and accelerated fuel particle heat-up rates. Study the effect of changes in reactor conditions on transient temperature profiles, pressure balance, and product gas composition. (3) Effects of Reactor Conditions on Syngas Composition--Evaluate the effect of air distribution, steam/coal ratio, solids circulation rate, and reactor temperature on CO/CO{sub 2} ratio, H{sub 2}/converted carbon ratio, gasification rates, carbon conversion, and cold and hot gas efficiencies. Test run GCT3 was started on December 1, 2000, with the startup of the thermal oxidizer fan, and was completed on February 1, 2001. This test was conducted in two parts; the loop seal was commissioned during the first part of this test run from December 1 through 15, which consisted of hot inert solids circulation testing. These initial tests provided preliminary data necessary to understand different parameters associated with the operation and performance of the loop seal. The loop seal was tested with coal feed during the second part of the test run and additional data was gathered to analyze reactor operations and to identify necessary modifications to improve equipment and process performance. In the second part of GCT3, the gasification portion of the test, from January 20 to February 1, 2001, the mixing zone and riser temperatures were varied between 1,675 and 1,825 F at pressures ranging from 200 to 240 psig. There were 306 hours of solid circulation and 184 hours of coal feed attained in GCT3.

  11. Identifying the need for a multidisciplinary approach for early recognition of mucopolysaccharidosis VI (MPS VI).

    Choy, Yew Sing; Bhattacharya, Kaustuv; Balasubramaniam, Shanti; Fietz, Michael; Fu, Antony; Inwood, Anita; Jin, Dong-Kyu; Kim, Ok-Hwa; Kosuga, Motomichi; Kwun, Young Hee; Lin, Hsiang-Yu; Lin, Shuan-Pei; Mendelsohn, Nancy J; Okuyama, Torayuki; Samion, Hasri; Tan, Adeline; Tanaka, Akemi; Thamkunanon, Verasak; Thong, Meow-Keong; Toh, Teck-Hock; Yang, Albert D; McGill, Jim

    2015-05-01

    Mucopolysaccharidosis VI (MPS VI, Maroteaux-Lamy syndrome) is caused by deficient activity of the enzyme, N-acetylgalactosamine-4-sulfatase, resulting in impaired degradation of the glycosaminoglycan dermatan sulfate. Patients experience a range of manifestations including joint contractures, short stature, dysostosis multiplex, coarse facial features, decreased pulmonary function, cardiac abnormalities, corneal clouding and shortened life span. Recently, clinicians from institutions in the Asia-Pacific region met to discuss the occurrence and implications of delayed diagnosis and misdiagnosis of MPS VI in the patients they have managed. Eighteen patients (44% female) were diagnosed. The most common sign presented by the patients was bone deformities in 11 patients (65%). Delays to diagnosis occurred due to the lack of or distance to diagnostic facilities for four patients (31%), alternative diagnoses for two patients (15%), and misleading symptoms experienced by two patients (15%). Several patients experienced manifestations that were subtler than would be expected and were subsequently overlooked. Several cases highlighted the unique challenges associated with diagnosing MPS VI from the perspective of different specialties and provide insights into how these patients initially present, which may help to elucidate strategies to improve the diagnosis of MPS VI. PMID:25892708

  12. Numerical analysis of isothermal JET injection into a denser liquid pool using RD-MPS Method

    Park, S. [KEPCO Nuclear Fuel, Daejeon (Korea, Republic of); Park, H. S. [POSTECH, Pohang (Korea, Republic of); Jeun, G. [Hanyang Univ., Seoul (Korea, Republic of)

    2012-03-15

    In this study, the rigid body dynamics coupled moving particle semi-implicit (RD-MPS) method was used to simulate a plunging liquid jet penetrating into a denser liquid pool. The phenomenon is related to fuel-coolant interactions (FCI) during severe accidents in nuclear power plants when coolant water is forcedly injected into a melt pool. A numerical particle method like MPS enables to simulate the complex multiphase flow in that significant deformation of fluids occurs due to its inherent grid less algorithm. However, the MPS method alone cannot continue the calculation for a long time as shown in the Ikea's work due to the large deformation of fluid surfaces and the difference in both liquid densities. In the RD-MPS method, the rigid body dynamics was coupled with the moving particle semi-implicit method to increase the overall stability of calculations and to calculate the multi-phase behavior of fluids. We performed two and three dimensional calculations to simulate jet penetration behaviors in a denser liquid pool, and the result was in good agreement with that of experiment. The simulation results suggested that the coupled model be useful in simulating dynamic interactions of multi-phase incompressible fluids as well as that the 3-D simulation for the plunging jet in a confined geometry predicted better agreement with experimental results than the 2-D simulation did.

  13. Numerical analysis of isothermal JET injection into a denser liquid pool using RD-MPS Method

    In this study, the rigid body dynamics coupled moving particle semi-implicit (RD-MPS) method was used to simulate a plunging liquid jet penetrating into a denser liquid pool. The phenomenon is related to fuel-coolant interactions (FCI) during severe accidents in nuclear power plants when coolant water is forcedly injected into a melt pool. A numerical particle method like MPS enables to simulate the complex multiphase flow in that significant deformation of fluids occurs due to its inherent grid less algorithm. However, the MPS method alone cannot continue the calculation for a long time as shown in the Ikea's work due to the large deformation of fluid surfaces and the difference in both liquid densities. In the RD-MPS method, the rigid body dynamics was coupled with the moving particle semi-implicit method to increase the overall stability of calculations and to calculate the multi-phase behavior of fluids. We performed two and three dimensional calculations to simulate jet penetration behaviors in a denser liquid pool, and the result was in good agreement with that of experiment. The simulation results suggested that the coupled model be useful in simulating dynamic interactions of multi-phase incompressible fluids as well as that the 3-D simulation for the plunging jet in a confined geometry predicted better agreement with experimental results than the 2-D simulation did

  14. Career Development: A Systems Approach.

    Slavenski, Lynn

    1987-01-01

    The author describes a comprehensive career development system implemented by Coca-Cola USA. The system's objectives are (1) to promote from within, (2) to develop talent for the future, (3) to make managers responsible for development efforts, and (4) to make individuals ultimately responsible for their development. (CH)

  15. Simulation of the QUEOS Experiment using Rigid Dynamic-Moving Particle Semi-Implicit (RD-MPS) Method

    Particle dissipation and mixing in liquid are common multiphase phenomena not only in nature and but also in industrial processes. Also, It is one of important phenomena in nuclear safety analysis on severe accidents associated with the coolability of the corium debris bed, in which the characteristics of the porous corium debris bed such as local porosity distribution, debris bed configuration, debris size distribution, porous structure etc., determined by the corium jet breakup, precipitation, and mixing processes are considered to be of importance. Therefore, we developed a new computational tool, called ADDA (Analysis of Debris Dynamics and Agglomeration), based on an enhanced MPS (Moving Particle Semi-implicit) algorithm (Park, 2011) to understand the complex debris dissipation and mixing phenomena and identify the roles of the debris characteristics in the process and verified against the QUEOS experiment (Meyer, 1996; 1997) performed at FzK in Germany

  16. Framework for control system development

    Control systems being developed for the present generation of accelerators will need to adapt to changing machine and operating state conditions. Such systems must also be capable of evolving over the life of the accelerator operation. In this paper we present a framework for the development of adaptive control systems

  17. Developing Temporal Systems

    Weist Richard M.

    2014-08-01

    Full Text Available This paper reviews a body of research that reveals how children acquire the capacity to express the temporal location of episodes that they remember and those they anticipate for the future. The paper shows how the childs knowledge of language structure provides a window on the conceptual development of memory processes and the capacity for conceptual time travel away from the conversational context of the speech act.

  18. Liferay Portal Systems Development

    Yuan, Jonas X

    2012-01-01

    This book focuses on teaching by example. Every chapter provides an overview, and then dives right into hands-on examples so you can see and play with the solution in your own environment. This book is for Java developers who don't need any prior experience with Liferay portal. Although Liferay portal makes heavy use of open source frameworks, no prior experience of using these is assumed.

  19. Geodyn systems development

    Putney, B. H.

    1984-01-01

    The purpose of the GEODYN Orbit Determination and Parameter Estimation, the SOLVE and ERODYN Programs is to recover geodetic and geophysical parameters from satellite and other data in a state-of-the-art manner. Continued solutions for gravity field, pole positions, Earth rotation, GM, and baselines were made as part of the Crustal Dynamics Project. Some tidal parameters were recovered as well. The eight digit station identification number was incorporated in the software and new techniques for constraining monthly station parameters to each other are being developed. This is allowing the analysts even more flexibility in the shaping of solutions from monthly sets of normal equations and right-hand sides.

  20. Master Pump Shutdown MPS Software Quality Assurance Plan (SQAP)

    The MPSS Software Quality Assurance (SQAP) describes the tools and strategy used in the development of the MPSS software. The document also describes the methodology for controlling and managing changes to the software

  1. Evaluation of possible failure of the mononuclear phagocyte system after total splenectomy in rats

    Marques Ruy Garcia

    2004-01-01

    Full Text Available Young and adult Wistar rats were submitted to total splenectomy and compared to animals not submitted to any surgical manipulation in order to evaluate the phagocytic function of spleen. The animals were infected with Escherichia coli labeled with technetium-99m and killed 20 minutes later. Liver, lung, spleen and a blood clot sample were taken. No significant differences were found in the percentage of bacterial radioactivity uptake in mononuclear phagocyte system (MPS organs in young and adult splenectomized rats. However, phagocytosis index by macrophages of MPS organs was smaller in splenectomized animals than in control group. Splenectomized rats were associated with a higher blood bacterial radioactivity uptake than animals of the control group (p<0.0001 due to a larger bacterial remnant in the bloodstream. This finding suggested that some failure in the MPS occurred in the absence of the spleen, demonstrating the need to develop alternative surgical techniques for total splenectomy.

  2. HLW Disposal System Development

    A KRS is suggested through design requirement analysis of the buffer and the canister which are the constituent of disposal system engineered barrier and HLW management plans are proposed. In the aspect of radionuclide retention capacity, the thickness of the buffer is determined 0.5m, the shape to be disc and ring and the dry density to be 1.6 g/cm3. The maximum temperature of the buffer is below 100 .deg. which meets the design requirement. And bentonite blocks with 5 wt% of graphite showed more than 1.0 W/mK of thermal conductivity without the addition of sand. The result of the thermal analysis for proposed double-layered buffer shows that decrease of 7 .deg. C in maximum temperature of the buffer. For the disposal canister, the copper for the outer shell material and cast iron for the inner structure material is recommended considering the results analyzed in terms of performance of the canisters and manufacturability and the geochemical properties of deep groundwater sampled from the research area with granite, salt water intrusion, and the heavy weight of the canister. The results of safety analysis for the canister shows that the criticality for the normal case including uncertainty is the value of 0.816 which meets subcritical condition. Considering nation's 'Basic Plan for Electric Power Demand and Supply' and based on the scenario of disposing CANDU spent fuels in the first phase, the disposal system that the repository will be excavated in eight phases with the construction of the Underground Research Laboratory (URL) beginning in 2020 and commissioning in 2040 until the closure of the repository is proposed. Since there is close correlation between domestic HLW management plans and front-end/back-end fuel cycle plans causing such a great sensitivity of international environment factor, items related to assuring the non-proliferation and observing the international standard are showed to be the influential factor and acceptability of HLW management plans to be the influential factor of making decision for social acceptability of nuclear power

  3. HLW Disposal System Development

    Choi, J. W.; Choi, H. J.; Lee, J. Y. (and others)

    2007-06-15

    A KRS is suggested through design requirement analysis of the buffer and the canister which are the constituent of disposal system engineered barrier and HLW management plans are proposed. In the aspect of radionuclide retention capacity, the thickness of the buffer is determined 0.5m, the shape to be disc and ring and the dry density to be 1.6 g/cm{sup 3}. The maximum temperature of the buffer is below 100 .deg. which meets the design requirement. And bentonite blocks with 5 wt% of graphite showed more than 1.0 W/mK of thermal conductivity without the addition of sand. The result of the thermal analysis for proposed double-layered buffer shows that decrease of 7 .deg. C in maximum temperature of the buffer. For the disposal canister, the copper for the outer shell material and cast iron for the inner structure material is recommended considering the results analyzed in terms of performance of the canisters and manufacturability and the geochemical properties of deep groundwater sampled from the research area with granite, salt water intrusion, and the heavy weight of the canister. The results of safety analysis for the canister shows that the criticality for the normal case including uncertainty is the value of 0.816 which meets subcritical condition. Considering nation's 'Basic Plan for Electric Power Demand and Supply' and based on the scenario of disposing CANDU spent fuels in the first phase, the disposal system that the repository will be excavated in eight phases with the construction of the Underground Research Laboratory (URL) beginning in 2020 and commissioning in 2040 until the closure of the repository is proposed. Since there is close correlation between domestic HLW management plans and front-end/back-end fuel cycle plans causing such a great sensitivity of international environment factor, items related to assuring the non-proliferation and observing the international standard are showed to be the influential factor and acceptability of HLW management plans to be the influential factor of making decision for social acceptability of nuclear power.

  4. Numerical analysis of jet injection mechanism of fuel-coolant interactions using MPS

    The numerical method used in this study is Moving Particle Semi-implicit (MPS) method which is based on moving particles and their interactions. Grids are not necessary, so that large fluid deformation can be calculated without numerical diffusion. To understand the fundamental physics of the jet penetration, water jet injection into a pool of a denser fluid under non-boiling and isothermal conditions is calculated using the MPS method. The density ratio of the denser fluid (Fluorinert) to water is 1.88. The calculation results are compared with experiments which were conducted in the ALPHA/MUSE facility at JAERI. In three-dimensional calculation, the penetration behavior agrees with the experiment. It is found that the jet penetration process is divided to two stages and, at the first stage, the coolant jet can penetrate deeper than existing correlations of breakup length. (author)

  5. Explicitly represented polygon wall boundary model for the explicit MPS method

    Mitsume, Naoto; Yoshimura, Shinobu; Murotani, Kohei; Yamada, Tomonori

    2015-05-01

    This study presents an accurate and robust boundary model, the explicitly represented polygon (ERP) wall boundary model, to treat arbitrarily shaped wall boundaries in the explicit moving particle simulation (E-MPS) method, which is a mesh-free particle method for strong form partial differential equations. The ERP model expresses wall boundaries as polygons, which are explicitly represented without using the distance function. These are derived so that for viscous fluids, and with less computational cost, they satisfy the Neumann boundary condition for the pressure and the slip/no-slip condition on the wall surface. The proposed model is verified and validated by comparing computed results with the theoretical solution, results obtained by other models, and experimental results. Two simulations with complex boundary movements are conducted to demonstrate the applicability of the E-MPS method to the ERP model.

  6. A new MPS {sup trademark} mill for the Veltheim Power Station

    Baumeister, W. [Gemeinschaftskraftwerk Weser GmbH, Veltheim (Germany); Bischoff, W.; Pannen, H. [BBP Energy GmbH, Oberhausen (Germany)

    2002-07-01

    Extensive tests in the coal grinding test field and in the flow laboratory, form together with the advanced CFD calculations as well as operating experience with over 2000 operating MPS ring and roller mills, the basis for the design of a new mill. In this the well-known principle of the MPS type ring and roller mill as best representative for hard coal pulverising worldwide has been retained. Tests at the size reduction model have shown that there is further potential for a higher output capacity. By means of new design and operating parameters the capacity was increased by more than 30%. It was necessary to verify these results at a test mill in a power plant. (orig.)

  7. Enzyme replacement therapy for Mucopolysaccharidosis Type I among patients followed within the MPS Brazil Network.

    Dornelles, Alícia Dorneles; de Camargo Pinto, Louise Lapagesse; de Paula, Ana Carolina; Steiner, Carlos Eduardo; Lourenço, Charles Marques; Kim, Chong Ae; Horovitz, Dafne Dain Gandelman; Ribeiro, Erlane Marques; Valadares, Eugênia Ribeiro; Goulart, Isabela; Neves de Souza, Isabel C; da Costa Neri, João Ivanildo; Santana-da-Silva, Luiz Carlos; Silva, Luiz Roberto; Ribeiro, Márcia; de Oliveira Sobrinho, Ruy Pires; Giugliani, Roberto; Schwartz, Ida Vanessa Doederlein

    2014-03-01

    Mucopolysaccharidosis type I (MPS I) is a rare lysosomal disorder caused by deficiency of alpha-L-iduronidase. Few clinical trials have assessed the effect of enzyme replacement therapy (ERT) for this condition. We conducted an exploratory, open-label, non-randomized, multicenter cohort study of patients with MPS I. Data were collected from questionnaires completed by attending physicians at the time of diagnosis (T1; n = 34) and at a median time of 2.5 years later (T2; n = 24/34). The 24 patients for whom data were available at T2 were allocated into groups: A, no ERT (9 patients; median age at T1 = 36 months; 6 with severe phenotype); B, on ERT (15 patients; median age at T1 = 33 months; 4 with severe phenotype). For all variables in which there was no between-group difference at baseline, a delta of ≥ ± 20% was considered clinically relevant. The following clinically relevant differences were identified in group B in T2: lower rates of mortality and reported hospitalization for respiratory infection; lower frequency of hepatosplenomegaly; increased reported rates of obstructive sleep apnea syndrome and hearing loss; and stabilization of gibbus deformity. These changes could be due to the effect of ERT or of other therapies which have also been found more frequently in group B. Our findings suggest MPS I patients on ERT also receive a better overall care. ERT may have a positive effect on respiratory morbidity and overall mortality in patients with MPS I. Additional studies focusing on these outcomes and on other therapies should be performed. PMID:24688287

  8. The Guided System Development Framework

    Carvalho Quaresma, Jose Nuno; Probst, Christian W.; Nielson, Flemming

    The Service-Oriented Computing paradigm has had significant influence on the Internet. With the emergence of this paradigm, it is important to provide tools that help developers designing and verifying such systems. In this article, we present the Guided System Development (GSD) Framework that ai...

  9. Molecular profiling of MPS1 gene silencing in U251 glioma cell line

    Uma Shankavaram

    2015-12-01

    Full Text Available Aneuploidy has been recognized as a common characteristic of cancers. Aneuploidy frequently results from errors of the mitotic checkpoint, the major cell cycle control mechanism that acts to prevent chromosome missegregation. Mutation of the genes that control chromosome segregation during mitosis may explain the high rate of chromosomal instability and aneuploidy, a characteristic of most solid tumors, including glioblastoma (GBM (Gordon et al., 2012 [1]; Singh et al., 2012 [2]. Monopolar spindle 1 (MPS1 is an essential spindle assembly checkpoint kinase that is overexpressed in several human cancers (Kilpinen et al., 2010 [3]; Mills et al., 1992 [4]; Yuan et al., 2006 [5]. In our previous publication, we have shown the role of MPS1 kinase in DNA repair and enhanced radiosensitivity in GBM (Maachani et al., 2015 [6]. Here, we provide methodological and analytical details of that study, to compare mRNA expression profile of siMPS1-silenced U251 cells with untransfected control, and siRNA control (siNeg at 6, 24, and 48 h after transfection. The raw data of this study is deposited in Gene Expression Omnibus under the accession number GSE57091.

  10. MPS Internships in Public Science Education: Sensing the Radio Sky

    Blake, Melvin; Castelaz, M. W.; Moffett, D.; Walsh, L.; LaFratta, M.

    2006-12-01

    The intent of the “Sensing the Radio Sky” program is to teach high school students the concepts and relevance of radio astronomy through presentations in STARLAB portable planetariums. The two year program began in the summer of 2004 and was completed in December 2006. The program involved a team of 12 undergraduate physics and multimedia majors and four faculty mentors from Furman University, University of North Carolina-Asheville and Pisgah Astronomical Research Institute (PARI). One component of the program is the development and production of a projection cylinder for the portable STARLAB planetariums. The cylinder gives a thorough view of the Milky Way and of several other celestial sources in radio wavelengths, yet these images are difficult to perceive without prior knowledge of radio astronomy. Consequently, the Radio Sky team created a multimedia presentation to accompany the cylinder. This multimedia component contains six informative lessons on radio astronomy assembled by the physics interns and numerous illustrations and animations created by the multimedia interns. The cylinder and multimedia components complement each other and provide a unique, thorough, and highly intelligible perspective on radio astronomy. The final draft is complete and will be sent to Learning Technologies, Inc., for marketing to owners of STARLAB planetariums throughout the world. We acknowledge support from the NSF Internship in Public Science Education Program grant number 0324729.

  11. Incremental value of 24-hour delayed imaging in 201Tl stress myocardial perfusion studies (MPS) with an 'early rest reinjection' protocol

    Full text: One hundred patients (pts) undergoing stress MPS had 24 h imaging for fixed defects at 4 h delayed imaging. 53 had prior myocardial infarction (MI) and 71 were males. Stress employed isotonic exercise with dipyridamole (0.56 mg kg-1) infusion in 57 pts, exercise alone in 33 and dipyridamole alone in 10. All pts with stress defects had rest-reinjection of 40 MBq of 201Tl after stress imaging had been completed, and most had sublingual nitrate therapy 10 min before reinjection. MPS from the 100 pts (15% of total) were read without clinical data, using a 20 segment scoring system. 51 pts showed -2 segments improvement between 4 and 24 h scores, but 22 pts had shown reversibility between stress and 4 h imaging and the further change did not alter interpretation. The other 29 pts (group A) showed clinically important change in 24 h scores, leaving 71 pts without clinical change (group B). Segmental improvement between 4 and 24 h in group A was 4.62 2.18 and 1.18 1.48 in group B (P = 0.02). Group A stress defect scores were not greater (10.90 3.60) or more severe (3.72 3.06) than in group B (8.92 4.34 and 2.79 3.11); 18 group A pts had MI compared with 38 group B pts. No significant correlation was found between improved 4-24 h scores and parameters of stress-LV dysfunction. There is benefit from 24 h, 201TI MPS in patients with persisting 4 h defects, despite early rest-reinjection and acute nitrate therapy

  12. Information system development activities and inquiring systems

    Carugati, Andrea

    2008-01-01

    This article presents a framework that maps information system development (ISD) activities on systems for the creation of knowledge. This work addresses the relevant and persisting problem of improving the chances of ISD success. The article builds upon previous research on knowledge aspects of...... ISD, abandoning the idea of a monolithic approach to knowledge and presenting a pluralistic approach based on the idea that different inquiring systems can support micro-level ISD activities. The article is divided into two parts. The first part presents the theoretical development of the framework...... based on ISD literature and on Churchman's (1971) inquiring systems. The second part presents the use of the framework in an ISD project. The case is used to show the applicability of the framework and to highlight the advantages of this approach. The main theoretical implication is that the framework...

  13. Firmware Development Improves System Efficiency

    Chern, E. James; Butler, David W.

    1993-01-01

    Most manufacturing processes require physical pointwise positioning of the components or tools from one location to another. Typical mechanical systems utilize either stop-and-go or fixed feed-rate procession to accomplish the task. The first approach achieves positional accuracy but prolongs overall time and increases wear on the mechanical system. The second approach sustains the throughput but compromises positional accuracy. A computer firmware approach has been developed to optimize this point wise mechanism by utilizing programmable interrupt controls to synchronize engineering processes 'on the fly'. This principle has been implemented in an eddy current imaging system to demonstrate the improvement. Software programs were developed that enable a mechanical controller card to transmit interrupts to a system controller as a trigger signal to initiate an eddy current data acquisition routine. The advantages are: (1) optimized manufacturing processes, (2) increased throughput of the system, (3) improved positional accuracy, and (4) reduced wear and tear on the mechanical system.

  14. The Impact of the Structure of the Education System on the Development of Educational Inequalities in the Czech Republic

    Straková, Jana

    2007-01-01

    Roč. 43, č. 3 (2007), s. 589-609. ISSN 0038-0288 R&D Projects: GA MPS 1J/005/04-DP2 Institutional research plan: CEZ:AV0Z70280505 Keywords : student achievement * socioeconomic status * selectivity of education system Subject RIV: AO - Sociology, Demography Impact factor: 0.169, year: 2007

  15. Developing web blog system for developer`s Helsinki Oy

    Akyereko, Prince

    2011-01-01

    This Bachelor’s thesis project is about web blogs and developing one with MySQL and PHP. The blogging system was built for Developer’s Helsinki Oy. Gathering the user requirements was done through reading of the documentation accompanying the project, reading the manuals of the older blog system and interaction with other developers and owners of the project. The goal was to build a web blog system for the users to send, read and comment on posts. The blog was built with PHP, CSS, MyS...

  16. Development of waste management system

    For implementation of disposal of the radioactive waste generated from Japan Atomic Energy Agency (JAEA), “Waste Management System” which manages all of the waste data has been developed. We surveyed the kinds of data needed for the waste management at each site, and we set the standard waste management data items. We developed conceptual design for the waste management system and established the system for major sites, Nuclear Science Research Institute, Ningyo-toge Environmental Engineering Center, Fugen Decommissioning Engineering Center, Oarai Research and Development Center, Nuclear Fuel Cycle Engineering Laboratories. For other small sites, we accumulate waste data to the common waste storage database. Therefore, we have developed the system which manages the quality assurance waste data depending on waste treatment situation in JAEA. (author)

  17. Exercise tolerance test (ett) or myocardial perfusion scan (mps) - what to choose in patients of ischaemic heart disease (ihd)

    Objective: To evaluate the validity of exercise tolerance test (ETT) with treadmill exercise in the diagnosis and follow-up of ischaemic heart disease (IHD), taking myocardial perfusion scan (MPS) as standard. Study Design: Retrospective, validation study. Place and Duration of Study: Nuclear Medical Centre (NMC) Armed Forces Institute of Pathology (AFIP), Rawalpindi, Pakistan, from 1 January to 31 December 2009. Patients and Methods: One hundred and nineteen patients (88 males, 31 females), referred for MPS; were selected through non-probability, consecutive sampling. Patients of all ages and gender, fit to undertake treadmill exercise, were included. Patients with contraindications to ETT, like unstable angina, conduction abnormalities, etc., or those who had taken a beta blocker within the preceding 24 hours, were excluded. ETT through treadmill exercise was done, followed by MPS with single photon emission computed tomography (SPECT) technique, using Thallium-201 or Technetium-99 m 2-methoxy-isobutyl-isonitrile (MIBI). ETT was interpreted as positive or negative for ischaemia, with borderline changes considered positive. MPS was interpreted as positive or negative for ischaemia. Validity of ETT was evaluated in terms of sensitivity (Sn), specificity (Sp), and positive and negative predictive value (PPV and NPV), taking MPS as standard. Results: Sensitivity of ETT was found to be 77.5% and specificity was 43.6%. PPV was 73.8% and NPV was 48.6%. Out of a total (n) of 119 patients, true positive (TP) cases were 62, true negative (TN) 17, false positive (FP) 22 and false negative (FN) 18. Conclusions: ETT is an acceptably sensitive but non-specific test for evaluating myocardial ischaemia, with adequate PPV but low NPV, when validating it against MPS. Replacing the MPS with ETT, in the diagnosis and follow-up of IHD, is thus, not prudent. ETT can be useful as a screening test. (author)

  18. Overview of the control system for the IFMIF/EVEDA accelerator

    The accelerator for Engineering Validation and Engineering Design Activity (EVEDA) of International Fusion Materials Irradiation Facility (IFMIF) will produce 9 MeV/125 mA CW beam. The IFMIF/EVEDA accelerator consists of Injector, RFQ, the first section of SC HWR Linac, etc. The control system for the IFMIF/EVEDA accelerator consists of Personnel Protection System (PPS), Machine Protection System (MPS), Central Control System (CCS), Local Area Network (LAN), Timing System (TS) and Local Control System (LCS). The PPS, MPS, CCS, LAN and TS have been developed by JAEA, and the LCS has been charged by EU. For these JAEA tasks, the design scenario taking into account of radio-activation, the development status and the development schedule for each accelerator components (Injector, RFQ, SC HWR linac, RF system, etc.) are presented in details. (author)

  19. Development of maintenance engineering system

    Department of JMTR project has developed the Maintenance Engineering System which evaluates the aging tendency of the facilities. The system is used for the repair plan and the replace period of parts, components, equipments or facilities. The system has the data-base which consists of the check data, the inspection data, the trouble data and the repair data at the JMTR since the virgin criticality. The system is utilized maintenance works and concludes the maintenance procedures for the failure components, equipments and facilities. This system has the following characteristics. (1) Anybody can operate the system as easily as word processor. (2) Data are put into by man-machine-interface. (3) The data sheets are with light color and the recognizable arrangements. (4) The system is cost-efficient using commercial personal computers and applications. The research card and the layouts of the input data sheet had been formatted. Data has been begun to be put into the system and to check its functions. The result demonstrates that the system is available for preventive maintenance at the JMTR. (author)

  20. DEVELOPMENT OF AN INSTRUCTIONAL SYSTEM.

    MELARAGNO, RALPH J.; NEWMARK, GERALD

    THE DEVELOPMENT OF AN INSTRUCTIONAL SYSTEM TO IMPROVE CLASSROOM INSTRUCTION IN READING FOR MEXICAN-AMERICAN STUDENTS IS DESCRIBED. AN EVALUATION-REVISION STRATEGY WAS UTILIZED TO INVESTIGATE THE EXTENT OF INTERACTIONS AMONG STUDENTS, MATERIALS, AND THE TEACHER. FOUR ELEMENTARY SCHOOLS IN LOS ANGELES PARTICIPATED IN THIS PROGRAM FOR 1 1/2 YEARS.…

  1. Charged particle detector system for high rate experiments

    A charged particle detector system under development at BNL for use at the Multiparticle Spectrometer (MPS) and eventually at ISABELLE is described. The object is to take full advantage of the position accuracy, resolving time and instantaneous rate capabilities of narrow anode spacing drift-proportional chambers. The system will have position resolution sigma approximately equal to 100?, time resolution approximately equal to 8 ns, detector sensitive time approximately equal to 50 ns, and consecutive particle resolving power of 40 ns per wire. It is planned to implement this system in a large system of 30,000 wires at the MPS and greater than 100,000 wires in ISABELLE experiments. Central to the development of this detector system is the production of two custom integrated circuits

  2. Development of safeguards system simulator

    Due to a large plutonium (Pu) throughput and high burn-up fuel in an advanced reprocessing plant, we have the responsibility to undertake the inevitable burden of nuclear material accountancy (NMA) to meet the International Atomic Energy Agency (IAEA) safeguards criteria. A large amount of sampling analysis and inspectors' activities result in a great cost in facility operation to verify no concealment and undeclared use of Pu. In addition to NMA, containment and surveillance (C/S), process monitoring (PM), and curium (Cm) balance have been used for the safeguards activities to complement NMA. However, except for NMA, any mathematical or regulatory formalism in the safeguards measures have not been presented so far, therefore it is difficult to evaluate the cost-effective performance of the safeguards system. In order to design an advanced safeguards system for the fast reactor fuel cycle, the JAEA has started to develop a safeguards system simulator. A NMA core in the simulator is composed of a near-real-time accounting (NRTA) code which had been already developed and applied to investigate the NMA characteristics of JAEA facilities. A 'multivariate and multi-scale core' is based on a multivariate mathematical analysis combined with a multi-scale statistical process analysis making use of a wavelet decomposition forms safeguards envelope, which provides a control and monitoring system logic. Multi-scale principle component analysis of the core had been applied to 'material unaccounted for' (MUF). A concept of multiple optimization core is proposed as the safeguards formalism, with probabilistic risk analysis and cost-performance characteristics of the safeguards system, is discussed in the presentation. Flow meter and non-destructive analysis can be more broadly applied to the system in a cost-effective manner. A virtual design and objective-driven model will be developed in the simulator in the future to support an effective safeguards design and to develop a walk-through' virtual plant model. (author)

  3. Mps1 and Ipl1/Aurora B act sequentially to correctly orient chromosomes on the meiotic spindle of budding yeast.

    Meyer, Régis E; Kim, Seoyoung; Obeso, David; Straight, Paul D; Winey, Mark; Dawson, Dean S

    2013-03-01

    The conserved kinases Mps1 and Ipl1/Aurora B are critical for enabling chromosomes to attach to microtubules so that partner chromosomes will be segregated correctly from each other, but the precise roles of these kinases have been unclear. We imaged live yeast cells to elucidate the stages of chromosome-microtubule interactions and their regulation by Ipl1 and Mps1 through meiosis I. Ipl1 was found to release kinetochore-microtubule (kMT) associations after meiotic entry, liberating chromosomes to begin homologous pairing. Surprisingly, most chromosome pairs began their spindle interactions with incorrect kMT attachments. Ipl1 released these improper connections, whereas Mps1 triggered the formation of new force-generating microtubule attachments. This microtubule release and reattachment cycle could prevent catastrophic chromosome segregation errors in meiosis. PMID:23371552

  4. Networking systems design and development

    Chao, Lee

    2009-01-01

    Effectively integrating theory and hands-on practice, Networking Systems Design and Development provides students and IT professionals with the knowledge and skills needed to design, implement, and manage fully functioning network systems using readily available Linux networking tools. Recognizing that most students are beginners in the field of networking, the text provides step-by-step instruction for setting up a virtual lab environment at home. Grounded in real-world applications, this book provides the ideal blend of conceptual instruction and lab work to give students and IT professional

  5. Implementation of alarm system for vibration monitoring of KOMAC facility

    Kim, Jae-Ha; Ahn, Tae-Sung; Song, Young-Gi; Kwon, Hyeok-Jung; Cho, Yong-Sub [KOMAC, Gyeongju (Korea, Republic of)

    2015-05-15

    For operating 100 MeV linac, Devices have to be operated in certain order. Thus malfunction of a device cause damage to linac and related devices. To protect linac, machine protect system (MPS) has been developed. The MPS protects the components by monitoring hardwired signals. When values of operating parameters go beyond or below limit, alarm will be generated and interlock system which stops related devices in certain sequence will run. Other factor, giving damage to linac is disaster. A strong vibration such as earthquake causes malfunction of devices and damage to linac. Against disaster, the monitoring system based on Experimental Physics and Industrial Control System (EPICS) was implemented. Configuration and Implementation of the monitoring system are presented and some preliminary results are reported. KOMAC implemented alarm system for a strong vibration and fire. Alarm is generated in unusual situation. Coping rapidly with situation, damages for Linac and related devices can be reduced.

  6. Implementation of alarm system for vibration monitoring of KOMAC facility

    For operating 100 MeV linac, Devices have to be operated in certain order. Thus malfunction of a device cause damage to linac and related devices. To protect linac, machine protect system (MPS) has been developed. The MPS protects the components by monitoring hardwired signals. When values of operating parameters go beyond or below limit, alarm will be generated and interlock system which stops related devices in certain sequence will run. Other factor, giving damage to linac is disaster. A strong vibration such as earthquake causes malfunction of devices and damage to linac. Against disaster, the monitoring system based on Experimental Physics and Industrial Control System (EPICS) was implemented. Configuration and Implementation of the monitoring system are presented and some preliminary results are reported. KOMAC implemented alarm system for a strong vibration and fire. Alarm is generated in unusual situation. Coping rapidly with situation, damages for Linac and related devices can be reduced

  7. Managing Sustainable Information Systems Development

    Kautz, Karlheinz

    . This paper is about a prerequisite for such products, namely, a sustainable ISD process, a process which exhibits reasonable and responsible stewardship and utilisation of the existing resources for ISD—people and information in the context of scope, time/schedule, budget/cost, quality and risk.......Sustainable information systems development (ISD) in the context of this paper is not about products that support sustainability at large with its environmental, economic and social dimensions and little about the development of sustainable products, which are both without doubt important topics...

  8. A Study on the Management of Micropollutants in Water System Considering Climate Change and other Potential Effects

    In this study, the management polices of micropollutants (MPs) were reviewed and the future management strategy was discussed considering climate change and etc. In Korea, the investigation of drinking water has been actively carried out for the priority contaminants as well as MPs. Recently river and lake waters have been also examined for MPs. However, the coverage and depth of the investigation is limited. Moreover, climate change is likely to increase air, water temperature and it will affect the hydrological cycle. Such changes may increase the residual concentrations of MPs in water system. As water reuse increases, the residual MPs of the recycled water may create public concerns. Thus, in a viewpoint of the precautionary principle, more stringent management of MPs is recommended for the drinking water and the body-contact water use. For the surface water, more studies are necessary to understand the ecological risk by MPs

  9. Development of pipe layout system

    In the plant design carried out so far, the process up to final drawings has been the repetition of the correction of drawings. This is because the space as the object of design is finite, and it is difficult to lay many pipes efficiently. Especially in nuclear power plants, the quantity of materials required for ensuring the safety and quality control is enormous, and only the skilled engineers having rich experience have become unable to deal with it. The model engineering using plastic models has been adopted, but still there are problems. In order to solve this problem, the development of the system for unitarily managing the various design information of plants with a computer, checking up various design with this information, automatically outputting design drawings and management data, and heightening the quality of design, synchronizing the progress, increasing the speed and saving the labor of design was carried out. This system is versatile and can be used for all plants. The emphasis in the development was placed on compact data structure, rapid picture processing and easy operation. The present status of design and the automation, the basic design of the system, the function of the system, the internal expression of models, the method of picture processing, and the results of application are reported. (Kako, I.)

  10. Remote Arrhythmia Monitoring System Developed

    York, David W.; Mackin, Michael A.; Liszka, Kathy J.; Lichter, Michael J.

    2004-01-01

    Telemedicine is taking a step forward with the efforts of team members from the NASA Glenn Research Center, the MetroHealth campus of Case Western University, and the University of Akron. The Arrhythmia Monitoring System is a completed, working test bed developed at Glenn that collects real-time electrocardiogram (ECG) signals from a mobile or homebound patient, combines these signals with global positioning system (GPS) location data, and transmits them to a remote station for display and monitoring. Approximately 300,000 Americans die every year from sudden heart attacks, which are arrhythmia cases. However, not all patients identified at risk for arrhythmias can be monitored continuously because of technological and economical limitations. Such patients, who are at moderate risk of arrhythmias, would benefit from technology that would permit long-term continuous monitoring of electrical cardiac rhythms outside the hospital environment. Embedded Web Technology developed at Glenn to remotely command and collect data from embedded systems using Web technology is the catalyst for this new telemetry system (ref. 1). In the end-to-end system architecture, ECG signals are collected from a patient using an event recorder and are transmitted to a handheld personal digital assistant (PDA) using Bluetooth, a short-range wireless technology. The PDA concurrently tracks the patient's location via a connection to a GPS receiver. A long distance link is established via a standard Internet connection over a 2.5-generation Global System for Mobile Communications/General Packet Radio Service (GSM/GPRS)1 cellular, wireless infrastructure. Then, the digital signal is transmitted to a call center for monitoring by medical professionals.

  11. ITER Plasma Control System Development

    Snipes, Joseph; ITER PCS Design Team

    2015-11-01

    The development of the ITER Plasma Control System (PCS) continues with the preliminary design phase for 1st plasma and early plasma operation in H/He up to Ip = 15 MA in L-mode. The design is being developed through a contract between the ITER Organization and a consortium of plasma control experts from EU and US fusion laboratories, which is expected to be completed in time for a design review at the end of 2016. This design phase concentrates on breakdown including early ECH power and magnetic control of the poloidal field null, plasma current, shape, and position. Basic kinetic control of the heating (ECH, ICH, NBI) and fueling systems is also included. Disruption prediction, mitigation, and maintaining stable operation are also included because of the high magnetic and kinetic stored energy present already for early plasma operation. Support functions for error field topology and equilibrium reconstruction are also required. All of the control functions also must be integrated into an architecture that will be capable of the required complexity of all ITER scenarios. A database is also being developed to collect and manage PCS functional requirements from operational scenarios that were defined in the Conceptual Design with links to proposed event handling strategies and control algorithms for initial basic control functions. A brief status of the PCS development will be presented together with a proposed schedule for design phases up to DT operation.

  12. Development of logistics information systems

    Milan Ž. Dronjak

    2012-10-01

    Full Text Available An adequate logistics information system provides real time automated data processing, distribution and of information according to Terrain Commander's requirements, which leads to timely fulfillment of logistic demands of units. SAP ERP The SAP ERP application is the integrated (ERP software capable of working with complex organisational structures, personnel, equipment, and finance. It enables planning and combining forces for every type of operations. The system also enables the determination of the readiness status of modelled forces. ISL The Information System for Logistics (ISL is a comprehensive information system of the Ministry of Defence (MoD and the Army of the Czech Republic that covers many areas: acquisition, supply, ammunition and equipment maintenance, logistics, etc. The ISL provides support for military logistics in all important areas of consumer and acquisition logistics, satisfaying all kinds of Defence Forces needs in the country and abroad. LOGFAS The information system LOGFAS comprises Logistics Database (LOGBASE, Movement and Transportation software (M&T, Allied Command Europe Resource Optimisation Software System (ACROSS and Logistic Reporting System (LOGREP. The Logistics Database LOGBASE represents a logistics information source and also a database related to assets, forces, geography, infrastructure, targets, supplies, movements and medical data. The main software tools which rely on the LOGBASE are M&T, ACROSS and LOGREP. GCSS-Army The original impetus to create the SALE came in the mid-90s when the United States Department of Defense (DoD started a logistics modernisation programme. One of tasks was to build The Single Army Logistics Enterprise (SALE for the purpose of covering the whole organisational structure of the DoD. There are three components of the SALE: GCSS-Army, PLM+ and LMP. Each of them uses the commercial Enterprise Resource Planning SAP Software with a Web access. The main component, GCSS-Army (Global Combat Support System-Army Field/Tactical, is intended for the tactical level and it will replace 14 tactical logistics information systems and connect them with the rest of the information environment. Tendencies in the development of logistics information systems In line with the presented information solutions, it is possible to extract relevant conclusions about tendencies in the development of these types of systems all around the world. These conclusions should be implemented, through adequate principles, into domestic software development. Three main tendencies are visible in modern solutions: using centralised databases, integration of existing separated software solutions, and connecting previously autonomus systems. Conclusion In accordance with present time requirements, logistic support should be realised as close as possible to the origin of a logistic need, in real time and adequately. Information systems enable real time delivery of information needed for a quality logistic support in all phases of operations as well as for a faster generation of all types of documents.

  13. Reciprocating Feed System Development Status

    Trewek, Mary (Technical Monitor); Blackmon, James B.; Eddleman, David E.

    2005-01-01

    The reciprocating feed system (RFS) is an alternative means of providing high pressure propellant flow at low cost and system mass, with high fail-operational reliability. The RFS functions by storing the liquid propellants in large, low-pressure tanks and then expelling each propellant through two or three small, high-pressure tanks. Each RFS tank is sequentially filled, pressurized, expelled, vented, and refilled so as to provide a constant, or variable, mass flow rate to the engine. This type of system is much lighter than a conventional pressure fed system in part due to the greatly reduced amount of inert tank weight. The delivered payload for an RFS is superior to that of conventional pressure fed systems for conditions of high total impulse and it is competitive with turbopump systems, up to approximately 2000 psi. An advanced version of the RFS uses autogenous pressurization and thrust augmentation to achieve higher performance. In this version, the pressurization gases are combusted in a small engine, thus making the pressurization system, in effect, part of the propulsion system. The RFS appears to be much less expensive than a turbopump system, due to reduced research and development cost and hardware cost, since it is basically composed of small high- pressure tanks, a pressurization system, and control valves. A major benefit is the high reliability fail-operational mode; in the event of a failure in one of the three tank-systems, it can operate on the two remaining tanks. Other benefits include variable pressure and flow rates, ease of engine restart in micro-gravity, and enhanced propellant acquisition and control under adverse acceleration conditions. We present a system mass analysis tool that accepts user inputs for various design and mission parameters and calculates such output values payload and vehicle weights for the conventional pressure fed system, the RFS, the Autogenous Pressurization Thrust Augmentation (APTA) RFS, and turbopump systems. Using this tool, a preliminary design of a representative crew exploration vehicle (CEV) has been considered. The design parameters selected for a representative system were modeled after the orbital maneuvering system (OMS) on the Shuttle Orbiter, with an increase of roughly a factor of ten in the delta- V capability and a greater thrust (30,000 lbs, vs. 12,000 lbs). Both storable and cryogenic propellants were considered. Results show that a RFS is a low mass alternative to conventional pressure fed systems, with a substantial increase in payload capability and that it is weight-competitive with turbopump systems at low engine pressure (a few hundred psi); at high engine pressures, the APTA RFS appears to offer the highest payload. We also present the status of the RFS test bed fabrication, assembly, and checkout. This test bed is designed to provide flow rates appropriate for engines in the roughly 10,000 to 30,000 lb thrust range.

  14. Bone mineral density in MPS IV A (Morquio syndrome type A).

    Kecskemethy, Heidi H; Kubaski, Francyne; Harcke, H T; Tomatsu, Shunji

    2016-02-01

    Mucopolysaccharidosis IV A (MPS IV A), Morquio A, is caused by deficiency in lysosomal enzyme N-acetylgalactosamine-6-sulfate sulfatase (GALNS), which is responsible for the catabolism of the glycosaminoglycans (GAGs) keratan sulfate (KS) and chondroitin 6-sulfate (C6S). Accumulation of GAGs results in disrupted cartilage formation and skeletal dysplasia. In this prospective cross-sectional study, bone mineral density (BMD) of the whole body (WB), lumbar spine (LS), and lateral distal femur (LDF) was acquired by dual-energy X-ray absorptiometry (DXA) on patients with MPS IV A. Functional abilities, medical history, Tanner score, and laboratory results were reviewed. Age and sex-matched norms were used to calculate Z-scores. Participants included 18 patients (13 females; 16 were unrelated) with a mean age of 21.4years (3.3 to 40.8years). While every patient was able to bear weight, 9 were full-time ambulators. Whole-body DXA could be obtained on only 6 patients (5 full-time ambulators) because of respiratory compromise caused by the position, presence of hardware, or positioning difficulties. Mean WB Z-score was -2.0 (range-0.3 to -4.1). Technical issues invalidating LS DXA in 8 patients included kyphosis at the thoracolumbar junction resulting in overlap of vertebrae in the posterior-anterior view. Mean LS BMD Z-score in full-time ambulators was -3.4 (range-1.6 to -5.0) and in the non-/partial ambulator was -4.0 (-3.7 to -4.2). Lateral distal femur BMD was acquired on every patient, and average Z-scores were -2 or less at all sites; full-time ambulators exhibited higher BMD. In conclusion, the LDF proved to be the most feasible site to measure in patients with MPS IV A. The higher LDF values in ambulators suggest this should be a consideration in promoting bone health for this group. PMID:26670863

  15. Development of Flood Warning System

    Joy J. Labo,

    2016-01-01

    Full Text Available Community-based early warning systems (CBEWS is a “people-centered” system and empowers individuals and communities threatened by hazards to act on sufficient time and in an appropriate manner to reduce the possibility of personal injury, loss of life, damage to property, environment and loss of livelihood. These things lead to the development of the device necessary for the protection of the community against flood hazards as it allows people to get prepared with sufficient time. An alarm system was developed to monitor the water level on Salog River that overflows during heavy rains. The water level sensors were submerged in a canal of water to test the functionality of the device before its installation. Computer programs were created to enhance the monitoring of water level: the River Monitor Software and the Water Level Monitor. The LED arrays emit light according to water level; green for low, orange for medium, and red for high. A siren also alarms with different intervals (30 seconds for low, 15 seconds for medium, and a continuous alarm for high. Automatic emergency lighting was integrated in the design and lights up during power outages powered by rechargeable sealed battery that charges when ac power is supplied to the device. Levels were established based on available data; low water level means awareness; medium water level means preparedness and high water level means immediate response is necessary.

  16. KSTAR RF heating system development

    Kwak, J. G.; Kim, S. K.; Hwang, C. K. (and others)

    2007-10-15

    Design, high-voltage test, and installation of 6 MW ICRF heating system for KSTAR is completed. The antenna demonstrated satisfactory standoff at high voltages up to 41 kV for 300 sec. The result indicates good power handling capabilities of the antenna as high as 10 MW/m2. This power density is equivalent to RF power coupling of 6 MW into a 4 {omega}/m target plasma, and is typical of advanced tokamak heating scenarios. In addition, vacuum feed through, DC break, and liquid stub developed for 300 sec operation are installed, as well as a 2 MW, 30-60MHz transmitter. The transmitter successfully produced output powers of 600 kW continuously, 1.5{approx}1.8 MW for 300 sec, and 2 MW for 100 msec or shorter pulses. A realtime control system based on DSP and EPICS is developed, installed, and tested on the ICRF system. Initial results from feasibility study indicate that the present antenna and the transmission lines could allow load-resilient operation on KSTAR. Until the KSTAR tokamak start to produce plasmas in 2008, however, hands-on operational experiences are obtained from participating in ICRF heating experiments at ASDEX and DIII-D tokamaks arranged through international cooperation.

  17. Expert system development (ESD) shell

    An Expert System Development (ESD) Shell design implementation is desribed in detail. The shell provides high-level generic facilities for Knowledge Representation (KR) and inferencing and tools for developing user interfaces. Powerful set of tools in the shell relieves much of the programming burden in the ES development. The shell is written in PROLOG under IBM PC/AT. KR facilities are based on two very powerful formalisms namely, frames and rules. Inference Engine (IE) draws most of its power from unification and backward reasoning strategy in PROLOG. This basic mechanism is enhanced further by incorporating both forward and backward chaining of rules and frame-based inferencing. Overall programming style integrates multiple paradigms including logic, object oriented, access-oriented and imperative programming. This permits ES designer a lot of flexibility in organizing inference control. Creation and maintainance of knowledge base is a major activity. The shell, therefore, provides number of facilities to simplify these tasks. Shell design also takes note of the fact that final success of any system depends on end-user satisfaction and hence provides features to build use-friendly interfaces. The shell also provides a set of interfacing predicates so that it can be embedded within any PROLOG program to incorporate functionalilty of the shell in the user program. (author). 10 refs., 8 figs

  18. Development of insulin delivery systems.

    Siddiqui, N I; Siddiqui, Ni; Rahman, S; Nessa, A

    2008-01-01

    Delivery system of insulin is vital for its acceptance and adherence to therapy for achieving the glycemic targets. Enormous developments have occurred in the delivery system of insulin during the last twenty years and each improvement was aimed at two common goals: patients convenience and better glycemic control. Till to date, the various insulin delivery systems are: syringes/vials, injection aids, jet injectors, transmucosal delivery, transdermal delivery, external insulin infusion pump, implantable insulin pumps, insulin pens and insulin inhalers. Syringe/vial is the oldest and conventional method, still widely used and relatively cheaper. Modern plastic syringes are disposable, light weight with microfine needle for patients convenience and comfort. Oral route could be the most acceptable and viable, if the barriers can be overcome and under extensive trial. Insulin pen device is an important milestone in the delivery system of insulin as it is convenient, discrete, painless, attractive, portable with flexible life style and improved quality of life. More than 80% of European diabetic patients are using insulin pen. Future digital pen will have better memory option, blood glucose monitoring system, insulin dose calculator etc. Insulin infusion pump is a good option for the children, busy patients with flexible lifestyle and those who want to avoid multiple daily injections. Pulmonary route of insulin delivery is a promising, effective, non-invasive and acceptable alternative method. Exubera, the world first insulin inhaler was approved by FDA in 28 January 2006. But due to certain limitations, it has been withdrawn from the market in October 2007. The main concern of inhaled insulin are: long term pulmonary safety issues, cost effectiveness and user friendly device. In future, more acceptable and cost effective insulin inhaler will be introduced. Newer avenues are under extensive trial for better future insulin delivery systems. PMID:18285745

  19. Compact Microscope Imaging System Developed

    McDowell, Mark

    2001-01-01

    The Compact Microscope Imaging System (CMIS) is a diagnostic tool with intelligent controls for use in space, industrial, medical, and security applications. The CMIS can be used in situ with a minimum amount of user intervention. This system, which was developed at the NASA Glenn Research Center, can scan, find areas of interest, focus, and acquire images automatically. Large numbers of multiple cell experiments require microscopy for in situ observations; this is only feasible with compact microscope systems. CMIS is a miniature machine vision system that combines intelligent image processing with remote control capabilities. The software also has a user-friendly interface that can be used independently of the hardware for post-experiment analysis. CMIS has potential commercial uses in the automated online inspection of precision parts, medical imaging, security industry (examination of currency in automated teller machines and fingerprint identification in secure entry locks), environmental industry (automated examination of soil/water samples), biomedical field (automated blood/cell analysis), and microscopy community. CMIS will improve research in several ways: It will expand the capabilities of MSD experiments utilizing microscope technology. It may be used in lunar and Martian experiments (Rover Robot). Because of its reduced size, it will enable experiments that were not feasible previously. It may be incorporated into existing shuttle orbiter and space station experiments, including glove-box-sized experiments as well as ground-based experiments.

  20. Social networks, politics and Commitment 2.0: Spanish MPs on Facebook

    José Sixto, B.A.

    2011-01-01

    Full Text Available In a technologically and sociologically advanced society, the organizations that do not use the new media and the cyber communication techniques are probably doomed to failure. In this virtual sphere the social networks constitute a suitable resource and channel for the implementation of political marketing 2.0, as it provides a scenario where the interaction with users is possible. From this perspective, we verified their presence of the 350 members of the Spanish Congress on Facebook, the country’s most popular social network, in order to establish the predominant typologies, updating frequency, contents, resources, and the types of information posted in this spaces.This article also examines the interactivity of MPs in what we have termed Commitment 2.0: political communication in personal contexts such as social networks requires going from the participatory attitude to the participatory action; that is, to accept the interaction 2.0 as the correct behaviour on the network.

  1. Development of targeted radiotherapy systems

    Conventional or external beam radiotherapy, has been a viable alternative for cancer treatment. Although this technique is effective, its use is limited if the patient has multiple malignant lesions (metastases). An alternative approach is based on the design of radiopharmaceuticals that, to be administered in the patient, are directed specifically toward the target cell producing a selective radiation delivery. This treatment is known as targeted radiotherapy. We have summarized and discussed some results related to our investigations on the development of targeted radiotherapy systems, including aspects of internal dosimetry

  2. Computer aided training system development

    The first three phases of Training System Development (TSD) -- job and task analysis, curriculum design, and training material development -- are time consuming and labor intensive. The use of personal computers with a combination of commercial and custom-designed software resulted in a significant reduction in the man-hours required to complete these phases for a Health Physics Technician Training Program at a nuclear power station. This paper reports that each step in the training program project involved the use of personal computers: job survey data were compiled with a statistical package, task analysis was performed with custom software designed to interface with a commercial database management program. Job Performance Measures (tests) were generated by a custom program from data in the task analysis database, and training materials were drafted, edited, and produced using commercial word processing software

  3. ADASAGE, ADA Application Development System

    1 - Description of program or function: ADASAGE is an application development system designed to facilitate rapid and professional construction of applications written in Ada on microcomputers. ADASAGE applications may vary in size from small to large multi-program systems. ADASAGE consists of a collection of re-usable libraries for database management and form and report processing utilities having the following capabilities: basic universal type and function definitions; sequential file input/output; terminal and file input/output; DOS system command execution; data movement and fill; string manipulation; math libraries; bit manipulation; a relational database utility; data validation; menu form and window procedures; report generation; sort/merge, time, and date functions; sound production; editing; and index rebuilding. Each of the capabilities is integrated to allow the development of an efficient system. As an application is designed and developed, the desired ADASAGE capabilities are chosen and included along with any requirements unique to that application. 2 - Method of solution: All ADASAGE applications which use the database, forms (windows, menus, etc.), or reporting functions require a file with a suffix of .DFL. This file contains the database schema, the various forms and windows, and report definitions. The THOR editor is used to create and maintain the .DFL file. This editor operates on a file with the suffix .SRC and creates and edits schemes, forms, and report formats and compile the .SRC file into the .DFL file used by the application. The application will have unique requirements not satisfied by the selected utilities of ADASAGE. The code for these along with the code necessary to import and use the selected ADASAGE utilities constitutes the programmed application. The completed application system will contain the .DFL file produced by the THOR editor, the required ADASAGE utilities, and the programmed application. During the course of normal database development and use, restructuring and/or rebuilding of database files may be required if the schema for a record is modified (new fields are added, changed, or deleted and new keys selected, etc.), or if the index file for a relation becomes damaged or is destroyed. Program REBUILD performs this task. The rebuilding process is invoked by supplying both an old .DFL file name identifying the schema definition under which the current data was written and a current .DFL file name identifying the new schema definition to which the current database must be changed. REBUILD compares the old and current schema definitions for a relation, adjusts the database files accordingly, and re-tags the database files with the new version so that access with the new schema is allowed. The index file for the relation is then rebuilt, and any unused space within the database files removed. 3 - Restrictions on the complexity of the problem: Maxima for each ADASAGE database are: 4,294,967,000 records (tuples) per record size; 32,000 bytes record (tuple) size; 32,000 fixed-length field (attribute size); 4,294,967,000 variable-length field (attribute) size; 1,000 relations (flat files); 1,000 joined relations; 1,000 views; 500 fields (attributes) per relation; 500 keyed fields per relation; 6,550 forms (windows); 55 significant digits in a number. The user's operating system or hardware may have more stringent limits than these

  4. Space Launch System Development Status

    Lyles, Garry

    2014-01-01

    Development of NASA's Space Launch System (SLS) heavy lift rocket is shifting from the formulation phase into the implementation phase in 2014, a little more than three years after formal program approval. Current development is focused on delivering a vehicle capable of launching 70 metric tons (t) into low Earth orbit. This "Block 1" configuration will launch the Orion Multi-Purpose Crew Vehicle (MPCV) on its first autonomous flight beyond the Moon and back in December 2017, followed by its first crewed flight in 2021. SLS can evolve to a130-t lift capability and serve as a baseline for numerous robotic and human missions ranging from a Mars sample return to delivering the first astronauts to explore another planet. Benefits associated with its unprecedented mass and volume include reduced trip times and simplified payload design. Every SLS element achieved significant, tangible progress over the past year. Among the Program's many accomplishments are: manufacture of Core Stage test panels; testing of Solid Rocket Booster development hardware including thrust vector controls and avionics; planning for testing the RS-25 Core Stage engine; and more than 4,000 wind tunnel runs to refine vehicle configuration, trajectory, and guidance. The Program shipped its first flight hardware - the Multi-Purpose Crew Vehicle Stage Adapter (MSA) - to the United Launch Alliance for integration with the Delta IV heavy rocket that will launch an Orion test article in 2014 from NASA's Kennedy Space Center. Objectives of this Earth-orbit flight include validating the performance of Orion's heat shield and the MSA design, which will be manufactured again for SLS missions to deep space. The Program successfully completed Preliminary Design Review in 2013 and Key Decision Point C in early 2014. NASA has authorized the Program to move forward to Critical Design Review, scheduled for 2015 and a December 2017 first launch. The Program's success to date is due to prudent use of proven technology, infrastructure, and workforce from the Saturn and Space Shuttle programs, a streamlined management approach, and judicious use of new technologies. The result is a safe, affordable, sustainable, and evolutionary path to development of an unprecedented capability for future missions across the solar system. In an environment of economic challenges, the nationwide SLS team continues to meet ambitious budget and schedule targets. This paper will discuss SLS program and technical accomplishments over the past year and provide a look at the milestones and challenges ahead.

  5. Matrix-Product-State Algorithm for Finite Fractional Quantum Hall Systems

    Liu, Zhao; Bhatt, R. N.

    2015-09-01

    Exact diagonalization is a powerful tool to study fractional quantum Hall (FQH) systems. However, its capability is limited by the exponentially increasing computational cost. In order to overcome this difficulty, density-matrix-renormalization-group (DMRG) algorithms were developed for much larger system sizes. Very recently, it was realized that some model FQH states have exact matrix-product-state (MPS) representation. Motivated by this, here we report a MPS code, which is closely related to, but different from traditional DMRG language, for finite FQH systems on the cylinder geometry. By representing the many-body Hamiltonian as a matrix-product-operator (MPO) and using single-site update and density matrix correction, we show that our code can efficiently search the ground state of various FQH systems. We also compare the performance of our code with traditional DMRG. The possible generalization of our code to infinite FQH systems and other physical systems is also discussed.

  6. StaMPS Improvement for Deformation Analysis in Mountainous Regions: Implications for the Damavand Volcano and Mosha Fault in Alborz

    Sanaz Vajedian

    2015-06-01

    Full Text Available Interferometric Synthetic Aperture Radar (InSAR capability to detect slow deformation over terrain areas is limited by temporal decorrelation, geometric decorrelation and atmospheric artefacts. Multitemporal InSAR methods such as Persistent Scatterer (PS-InSAR and Small Baseline Subset (SBAS have been developed to deal with various aspects of decorrelation and atmospheric problems affecting InSAR observations. Nevertheless, the applicability of both PS-InSAR and SBAS in mountainous regions is still challenging. Correct phase unwrapping in both methods is hampered due to geometric decorrelation in particular when using C-band SAR data for deformation analysis. In this paper, we build upon the SBAS method implemented in StaMPS software and improved the technique, here called ISBAS, to assess tectonic and volcanic deformation in the center of the Alborz Mountains in Iran using both Envisat and ALOS SAR data. We modify several aspects within the chain of the processing including: filtering prior to phase unwrapping, topographic correction within three-dimensional phase unwrapping, reducing the atmospheric noise with the help of additional GPS data, and removing the ramp caused by ionosphere turbulence and/or orbit errors to better estimate crustal deformation in this tectonically active region. Topographic correction is done within the three-dimensional unwrapping in order to improve the phase unwrapping process, which is in contrast to previous methods in which DEM error is estimated before/after phase unwrapping. Our experiments show that our improved SBAS approach is able to better characterize the tectonic and volcanic deformation in the center of the Alborz region than the classical SBAS. In particular, Damavand volcano shows an average uplift rate of about 3 mm/year in the year 2003–2010. The Mosha fault illustrates left-lateral motion that could be explained with a fault that is locked up to 17–18 km depths and slips with 2–4 mm/year below that depth.

  7. The Simulator of the Timing and Magnitude of Pollen Season (STaMPS model: a pollen production model for regional emission and transport modeling

    T. R. Duhl

    2013-04-01

    Full Text Available A pollen model that simulates the timing and production of wind-dispersed allergenic pollen by terrestrial, temperate vegetation has been developed to quantify how pollen occurrence may be affected by climate change and to investigate how pollen can interact with anthropogenic pollutants to affect human health. The Simulator of the Timing and Magnitude of Pollen Season (STaMPS model is driven by local meteorological conditions and is designed to be sensitive to climate shifts, as well as flexible with respect to the vegetation species and plant functional types (trees, grasses, etc. represented and the climate zones simulated. The initial focus for the model is the simulation of the pollen emission potential of important allergenic tree and grass species that typically flower between March–June in Southern California (S. CA, which is characterized by moderate Mediterranean and oceanic climate zones as well as regions of arid desert and arid steppe. Vegetation cover and species composition data are obtained from numerous datasets and a database of allergenic vegetation species, their pollen production potential and relative allergenicities has been developed. For the selected allergenic species and spring-early summer simulation period, temperature is the main driver controlling the timing of pollen release, while precipitation (and temperature, for some species controls the magnitude of pollen produced. The model provides species-specific pollen potential maps for each day of the simulation period; these are then used by a pollen transport model to simulate ambient pollen concentrations as described in a companion paper (Zhang et al., 2013a, which also presents model evaluation results for the S. CA model domain. The STaMPS model was also used to quantify the possible impact of climate change on pollen season under the IPCC SRES A1B scenario as simulated by the ECHAM5 global climate model. Current (1995–2004 and future (2045–2054 meteorological conditions downscaled using the Weather Research and Forecasting (WRF model were used to drive STaMPS and generate estimates of the relative magnitude and timing of pollen season for important allergenic tree and grass species that bloom from March through June in a larger domain that covers all of CA and Nevada. Differences in the simulated timing and magnitude of pollen season for the selected allergenic species under current and future climate scenarios are presented. The results suggest that across all of the simulated species, pollen season starts an average of 5–6 days earlier under predicted future climatic conditions with an associated average annual domain-wide temperature increase of about 1°C compared to simulated current conditions. Differences in the amount of pollen produced under the two scenarios vary by species and are affected by the selected simulation period (1 March–30 June. Uncertainties associated with the STaMPS model and future model development plans are also discussed.

  8. Systems biology study of mucopolysaccharidosis using a human metabolic reconstruction network.

    Salazar, Diego A; Rodríguez-López, Alexander; Herreño, Angélica; Barbosa, Hector; Herrera, Juliana; Ardila, Andrea; Barreto, George E; González, Janneth; Alméciga-Díaz, Carlos J

    2016-02-01

    Mucopolysaccharidosis (MPS) is a group of lysosomal storage diseases (LSD), characterized by the deficiency of a lysosomal enzyme responsible for the degradation of glycosaminoglycans (GAG). This deficiency leads to the lysosomal accumulation of partially degraded GAG. Nevertheless, deficiency of a single lysosomal enzyme has been associated with impairment in other cell mechanism, such as apoptosis and redox balance. Although GAG analysis represents the main biomarker for MPS diagnosis, it has several limitations that can lead to a misdiagnosis, whereby the identification of new biomarkers represents an important issue for MPS. In this study, we used a system biology approach, through the use of a genome-scale human metabolic reconstruction to understand the effect of metabolism alterations in cell homeostasis and to identify potential new biomarkers in MPS. In-silico MPS models were generated by silencing of MPS-related enzymes, and were analyzed through a flux balance and variability analysis. We found that MPS models used approximately 2286 reactions to satisfy the objective function. Impaired reactions were mainly involved in cellular respiration, mitochondrial process, amino acid and lipid metabolism, and ion exchange. Metabolic changes were similar for MPS I and II, and MPS III A to C; while the remaining MPS showed unique metabolic profiles. Eight and thirteen potential high-confidence biomarkers were identified for MPS IVB and VII, respectively, which were associated with the secondary pathologic process of LSD. In vivo evaluation of predicted intermediate confidence biomarkers (β-hexosaminidase and β-glucoronidase) for MPS IVA and VI correlated with the in-silico prediction. These results show the potential of a computational human metabolic reconstruction to understand the molecular mechanisms this group of diseases, which can be used to identify new biomarkers for MPS. PMID:26276570

  9. Project management for information system development

    Zhang, Yang

    2011-01-01

    Nowadays, with the development of the information and communication technology, information systems have been developing rapidly. More and more software companies choose to develop the information system to be their main business. They want to increase their business profits by developing the information system. However, the failure rate of developing information system has been high during these years. The purpose of the thesis is to discover how to use project management knowledge to improv...

  10. Development of readout systems for neutron detectors

    Satoh, S. E-mail: setsuo.satoh@kek.jp; Ino, T.; Furusaka, M.; Kiyanagi, Y.; Sakamoto, N.; Sakai, K

    2004-08-21

    A readout electronics system for linear position sensitive {sup 3}He gas detectors has been developed. It is widely used for neutron scattering instruments at KEK Neutron Science Laboratory (KENS). The basic structure of the system is quite versatile, and can be used for various imaging-systems. Several versatile readout systems have been developed at KENS. As one of such examples, a 2-dimensional imaging-system for a wavelength shifting fiber based scintillation counter system has been developed.

  11. Characterization of the MPS I-H knock-in mouse reveals increased femoral biomechanical integrity with compromised material strength and altered bone geometry

    Arin K. Oestreich

    2015-12-01

    Full Text Available Mucopolysaccharidosis type I (MPS I, is an autosomal recessive lysosomal storage disorder caused by a deficiency in the α-L-iduronidase enzyme, resulting in decreased enzymatic activity and accumulation of glycosaminoglycans. The disorder phenotypically manifests with increased urine glycosaminoglycan excretion, facial dysmorphology, neuropathology, cardiac manifestations, and bone deformities. While the development of new treatment strategies have shown promise in attenuating many symptoms associated with the disorder, the bone phenotype remains unresponsive. The aim of this study was to investigate and further characterize the skeletal manifestations of the Idua-W392X knock-in mouse model, which carries a nonsense mutation corresponding to the IDUA-W402X mutation found in Hurler syndrome (MPS I-H patients. μCT analysis of the microarchitecture demonstrated increased cortical thickness, trabecular number, and trabecular connectivity along with decreased trabecular separation in the tibiae of female homozygous Idua-W392X knock-in (IDUA−/− mice, and increased cortical thickness in male IDUA−/− tibiae. Cortical density, as determined by μCT, and bone mineral density distribution, as determined by quantitative backscattered microscopy, were equivalent in IDUA−/− and wildtype (Wt bone. However, tibial porosity was increased in IDUA−/− cortical bone. Raman spectroscopy results indicated that tibiae from female IDUA−/− had decreased phosphate to matrix ratios and increased carbonate to phosphate ratios compared to Wt female tibiae, whereas these ratios remained equivalent in male IDUA−/− and Wt tibiae. Femora demonstrated altered geometry and upon torsional loading to failure analysis, female IDUA−/− mouse femora exhibited increased torsional ultimate strength, with a decrease in material strength relative to Wt littermates. Taken together, these findings suggest that the IDUA−/− mutation results in increased bone torsional strength by altering the overall bone geometry and the microarchitecture which may be a compensatory response to increased porosity, reduced bone tensile strength and altered physiochemical composition.

  12. Sample preparation of membrane proteins suitable for solid-state MAS NMR and development of assignment strategies

    Hiller, Matthias

    2009-01-01

    Although the basic structure of biological membranes is provided by the lipid bilayer, most of the specific functions are carried out by membrane proteins (MPs) such as channels, ion-pumps and receptors. Additionally, it is known, that mutations in MPs are directly or indirectly involved in many diseases. Thus, structure determination of MPs is of major interest not only in structural biology but also in pharmacology, especially for drug development. Advances in structural biology of membrane...

  13. Allogeneic bone marrow transplantation and donor lymphocyte infusion in a mouse model of irradiation-induced myelodysplastic/myeloproliferation syndrome (MD/MPS): evidence for a graft-versus-MD/MPS effect

    Sprangers, Ben; Van Wijmeersch, Bart; Luyckx, Ariane; Sagaert, Xavier; De Somer, Lien; Rutgeerts, Omer; Lenaerts, Caroline; Landuyt, Willy; Boeckx, Nancy; Dubois, Bndicte; De Wolf-Peeters, Christiane; Waer, Mark; Billiau, An

    2009-01-01

    The role of graft-versus-malignancy reactivity in the effects of allogeneic hematopoietic stem cell transplantation and donor lymphocyte infusion (DLI) for myelodysplastic syndromes is as yet not well established. Clinical data are limited and animal models are scarce. Here, we report on the effects of allogeneic bone marrow transplantation (BMT) and DLI in a novel model of irradiation-induced murine myelodysplastic /myeloproliferation syndrome (MD/MPS). Total body irradiation with 8.5 Gra...

  14. Electro-Optic System Development Lab

    Federal Laboratory Consortium — The Electro-Optic System Development Lab serves as a development facility for electro-optical systems ranging from visible through long wave infrared. Capabilities...

  15. Severe phenotype in MPS II patients associated with a large deletion including contiguous genes.

    Brusius-Facchin, Ana Carolina; De Souza, Carolina Fischinger Moura; Schwartz, Ida Vanessa D; Riegel, Mariluce; Melaragno, Maria Isabel; Correia, Patrícia; Moraes, Lúcia Marques; Llerena, Juan; Giugliani, Roberto; Leistner-Segal, Sandra

    2012-05-01

    Hunter disease or mucopolysaccharidosis type II (MPS II) is an X-linked recessive lysosomal disorder caused by the deficiency of iduronate-2-sulfatase, which is involved in the catabolism of the glycosaminoglycans (GAGs) heparan and dermatan sulphate. Our aim was to analyze three patients with severe Hunter syndrome that showed a total deletion of the iduronate-2-sulphatase (IDS) gene, after exon by exon PCR. DNA was used as a template for PCR synthesis of IDS, FRAXA, FRAXE, and DXS1113 specific amplicons. The DNA analysis for all three patients demonstrated a complete deletion of IDS, FRAXA, and FRAXE contiguous genes. We further performed SNP-array to delineate the deletion breakpoints and to characterize the deletion extension in the different patients. The results indicated a ∼9.4 Mb deletion in Patient 1, a ∼3.9 Mb deletion of the Xq27.3-Xq28 and a ∼3.1 Mb duplication of the X q28 region in Patient 2 and a ∼41.8 Kb deletion in Patient 3. SNP-array was shown to be important to map for deletion breakpoints. A comprehensive molecular analysis in patients with Hunter syndrome, especially in the ones presenting the severe form, is important to the understanding of the genetic determinants of the phenotype and for the genetic counseling to be provided to the families. PMID:22492741

  16. Common N-acetylgalactosamine-6-sulfate sulfatase (GALNS exon mutations in Brazilian patients with mucopolysaccharidosis IVA (MPS IVA

    Tatiana Dieter

    2007-01-01

    Full Text Available Morquio A Syndrome (mucopolysaccharidosis IVA - MPS IVA, OMIM# 253000 is an autosomal recessive inborn error of metabolism caused by the deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS. We investigated five unrelated Brazilian MPS IVA families for mutations in exons 4, 5, 9 and 10 of the GALNS gene. Six out of the 10 mutant alleles were identified. Taken together with a previous study, which included six unrelated families, common mutations among Brazilian patients were p.N164T, p.G116S and p.G301C. Among one hundred control subjects three novel silent mutations were found (p.A107A; GCC -> GCT, p.Y108Y; TAC -> TAT, p.P357P; CCG -> CCA. Screening starting with exons 4, 5, 9, 10 and 11 may be a good strategy for genotyping of Brazilian patients since these exons include 73% of all mutations identified in the current and previous studies.

  17. Growth of MPS-capped ZnS quantum dots in self-assembled thin films: Influence of heat treatment

    Koç, Kenan; Tepehan, Fatma Zehra; Tepehan, Galip Gültekin

    2015-12-01

    The colloidal ZnS quantum dots (QDs) were prepared using 3-mercaptopropyltrimethoxysilane (MPS) molecules. Sol-gel spin coating method was used to deposit the colloidal nanoparticles on a glass substrate. Several features of the MPS were made use to produce self assembled thin films of ZnS quantum dots in a SiO2 network. Produced films were heat treated in between 225 °C and 325 °C to investigate their growth kinetics. The result showed that their size changed approximately from 3 nm to 4 nm and the first excitation peak position changed from 4.6 eV to 4.1 eV in this temperature interval. The activation energy of the nanoparticles for the Ostwald ripening process was found to be 59 kJ/mol.

  18. APPROACHING DEVELOPMENT IN LOGISTIC INFORMATION SYSTEMS

    Louis F Buys

    2012-01-01

    The introduction of technology into modern defence necessitates integrated computerized information systems to render effective and efficient logistic support. Traditional information system development does not ensure attainment of use and time scale requirements in the continuously developing environment of logistics. This paper describes current approaches to the development of logistic information systems.

  19. MEASUREMENT PROCESS OF SOFTWARE DEVELOPMENT PROJECTS FOR SUPPORTING STRATEGIC BUSINESS OBJECTIVES IN SOFTWARE DEVELOPING COMPANIES

    Sandra Lais Pedroso

    2013-08-01

    Full Text Available Software developing companies work in a competitive market and are often challenged to make business decisions with impact on competitiveness. Models accessing maturity for software development processes quality, such as CMMI and MPS-BR, comprise process measurements systems (PMS. However, these models are not necessarily suitable to support business decisions, neither to achieve strategic goals. The objective of this work is to analyze how the PMS of software development projects could support business strategies for software developing companies. Results taken from this work show that PMS results from maturity models for software processes can be suited to help evaluating operating capabilities and supporting strategic business decisions.

  20. Developing Information Systems for Competitive Intelligence Support.

    Hohhof, Bonnie

    1994-01-01

    Discusses issues connected with developing information systems for competitive intelligence support; defines the elements of an effective competitive information system; and summarizes issues affecting system design and implementation. Highlights include intelligence information; information needs; information sources; decision making; and

  1. Developing a Remote Maintenance system

    Ambaye, Michael

    2014-01-01

    Computerized Maintenance Management Systems (CMMS) is a method by which we can bust the efficiency of a company’s maintenance system. By using CMMS a company can easily predict future maintenance dates, costs and so on. For example, if a company owns a machine worth millions of dollars, then they intend to keep it working all the time. But because of accidental breakdown they could lose not only repair cost but also disappointed customers. This project was meant to address issues of monitor...

  2. First human treatment with investigational rhGUS enzyme replacement therapy in an advanced stage MPS VII patient.

    Fox, Joyce E; Volpe, Linda; Bullaro, Josephine; Kakkis, Emil D; Sly, William S

    2015-02-01

    Mucopolysaccharidosis type VII (MPS VII, Sly syndrome) is a very rare lysosomal storage disease caused by a deficiency of the enzyme β-glucuronidase (GUS), which is required for the degradation of three glycosaminoglycans (GAGs): dermatan sulfate, heparan sulfate, and chondroitin sulfate. Progressive accumulation of these GAGs in lysosomes leads to increasing dysfunction in numerous tissues and organs. Enzyme replacement therapy (ERT) has been used successfully for other MPS disorders, but there is no approved treatment for MPS VII. Here we describe the first human treatment with recombinant human GUS (rhGUS), an investigational therapy for MPS VII, in a 12-year old boy with advanced stage MPS VII. Despite a tracheostomy, nocturnal continuous positive airway pressure, and oxygen therapy, significant pulmonary restriction and obstruction led to oxygen dependence and end-tidal carbon dioxide (ETCO2) levels in the 60-80mmHg range, eventually approaching respiratory failure (ETCO2 of 100mmHg) and the need for full-time ventilation. Since no additional medical measures could improve his function, we implemented experimental ERT by infusing rhGUS at 2mg/kg over 4h every 2 weeks for 24 weeks. Safety was evaluated by standard assessments and observance for any infusion associated reactions (IARs). Urinary GAG (uGAG) levels, pulmonary function, oxygen dependence, CO2 levels, cardiac valve function, liver and spleen size, and growth velocity were assessed to evaluate response to therapy. rhGUS infusions were well tolerated. No serious adverse events (SAEs) or IARs were observed. After initiation of rhGUS infusions, the patient's uGAG excretion decreased by more than 50%. Liver and spleen size were reduced within 2 weeks of the first infusion and reached normal size by 24 weeks. Pulmonary function appeared to improve during the course of treatment based on reduced changes in ETCO2 after off-ventilator challenges and a reduced oxygen requirement. The patient regained the ability to eat orally, gained weight, and his energy and activity levels increased. Over 24 weeks, treatment with every-other-week infusions of rhGUS was well tolerated with no SAEs, IARs, or hypersensitivity reactions and was associated with measurable improvement in objective clinical measures and quality of life. PMID:25468648

  3. Developing a Management System (AMOAS).

    Morrell, James E.; Price, Bonnie B.

    To evaluate their school management personnel, the Muhlenberg (Pennsylvania) School District adopted the Administrative Management by Objectives Appraisal System (AMOAS). Administrators are evaluated on the basis of objectives that they establish in conjunction with their immediate supervisor and on everyday job performance. Above satisfactory

  4. Security alarm communication and display systems development

    Sandia National Laboratories (SNL) has, as lead Department of Energy (DOE) physical security laboratory, developed a variety of alarm communication and display systems for DOE and Department of Defense (DOD) facilities. This paper briefly describes some of the systems developed and concludes with a discussion of technology relevant to those currently designing, developing, implementing, or procuring such a system. Development activities and the rapid evolution of computers over the last decade have resulted in a broad variety of capabilities to support most security system communication and display needs. The major task in selecting a system is becoming familiar with these capabilities and finding the best match to a specific need

  5. Computer graphics for robot system development

    The role of computer graphics in the development of a robot system is described. Emphasis is placed on the use of graphics simulation and robotic system animation for software development, system monitoring, operator assistance during manual error recovery, and operator training

  6. Development of Baby-EBM Interface System

    This paper explains the works being done to develop an interface system for Baby-Electron Beam Machine (EBM). The function of the system is for the safety, controlling and monitoring the Baby-EBM. The integration for the system is using data acquisition (DAQ) hardware and LabVIEW to develop the software. (author)

  7. X2000 power system electronics development

    Carr, Greg; Deligiannis, Frank; Franco, Lauro; Jones, Loren; Lam, Barbara; Nelson, Ron; Pantaleon, Jose; Ruiz, Ian; Treichler, John; Wester, Gene; Sauers, Jim; Giampoli, Paul; Haskell, Russ; Mulvey, Jim; Repp, John

    2005-01-01

    The X2000 Power System Electronics (PSE) is a Jet Propulsion Laboratory (JPL) task to develop a new generation of power system building blocks for potential use on future deep space missions. The effort includes the development of electronic components and modules that can be used as building blocks in the design of generic spacecraft power systems.

  8. Development of NIR bioimaging systems

    Soga, K; Tsuji, T; Tashiro, F; Chiba, J [Polyscale Technology Research Center, Tokyo University of Science (Japan); Oishi, M; Yoshimoto, K; Nagasaki, Y [Tsukuba Research Center for Interdisciplinary Materials Science, University of Tsukuba (Japan); Kitano, K; Hamaguchi, S [Center for Atomic and Molecular Technologies, Osaka University (Japan)], E-mail: mail@ksoga.com

    2008-03-15

    Fluorescence bioimaging is one of the most important technologies in the biomedical field. The most serious issue concerning current fluorescence bioimaging systems is the use of short wavelength light, UV or VIS, for the excitation of phosphors such as fluorescent proteins or quantum dots. The authors propose a fluorescence bioimaging system excited by near infrared light using rare-earth doped ceramic nanophosphors. The requirements for the nanophosphors are a designed emission scheme under the near infrared excitation, a controlled size between 10 and 200 nm and surface modification of the particles with a bio-functional polymer, which prevents particle agglomeration and non-specific interaction to non-targeting substances and gives them a specific interaction for the targeted objects. The preparation of the bioimaging probe and demonstrative imaging work are reported.

  9. Development of NIR bioimaging systems

    Fluorescence bioimaging is one of the most important technologies in the biomedical field. The most serious issue concerning current fluorescence bioimaging systems is the use of short wavelength light, UV or VIS, for the excitation of phosphors such as fluorescent proteins or quantum dots. The authors propose a fluorescence bioimaging system excited by near infrared light using rare-earth doped ceramic nanophosphors. The requirements for the nanophosphors are a designed emission scheme under the near infrared excitation, a controlled size between 10 and 200 nm and surface modification of the particles with a bio-functional polymer, which prevents particle agglomeration and non-specific interaction to non-targeting substances and gives them a specific interaction for the targeted objects. The preparation of the bioimaging probe and demonstrative imaging work are reported

  10. The Development of Surveillance Systems.

    Henderson, D A

    2016-03-01

    Surveillance systems in public health practice have increased in number and sophistication with advances in data collection, analysis, and communication. When the Communicable Disease Center (now the Centers for Disease Control and Prevention) was founded some 70 years ago, surveillance referred to the close observation of individuals with suspected smallpox, plague, or cholera. Alexander Langmuir, head of the Epidemiology Branch, redefined surveillance as the epidemiology-based critical factor in infectious disease control. I joined Langmuir as assistant chief in 1955 and was appointed chief of the Surveillance Section in 1961. In this paper, I describe Langmuir's redefinition of surveillance. Langmuir asserted that its proper use in public health meant the systematic reporting of infectious diseases, the analysis and epidemiologic interpretation of data, and both prompt and widespread dissemination of results. I outline the Communicable Disease Center's first surveillance systems for malaria, poliomyelitis, and influenza. I also discuss the role of surveillance in the global smallpox eradication program, emphasizing that the establishment of systematic reporting systems and prompt action based on results were critical factors of the program. PMID:26928219

  11. Developing TRUPACT system impact resistance

    The Transportation Technology Center at Sandia National Laboratories has taken the lead in the development of the TRansUranic PACkage Transporter I (TRUPACT-I) for transporting contact-handled transuranic waste. TRUPACT-I is a Type B package designed for transport by truck and rail. One of the regulatory requirements of a Type B package is that it survive a drop onto a 15.2-cm-dia punch. This paper discusses the development of the puncture resistant panels used in TRUPACT-I. Concepts tested ranged from monolithic steel plates to laminated Kevlar fabric bonded to a steel backing plate. The TRUPACT-I wall design incorporated the laminated Kevlar and stainless steel puncture panel

  12. Product/Service-System Development

    Tan, Adrian; McAloone, Timothy Charles; Gall, Catherine

    2007-01-01

    ‘Product/service-systems’ (PSS) are innovation strategies where instead of focusing on the value of selling physical products, one focuses on the value of the utility of products and services throughout the product’s life period. This approach enables companies to provide customers with offerings...... that continuously deliver value and create a strong competitive advantage. PSS attempts to transcend the old industrial credo that value is embedded in products and the consideration of ‘cost-quality-time’ relates to the physical artefact. While there is increasing interest in PSS, limited research has...... been done in the design and development aspects of PSS. The objective of this paper is to explore how a global manufacturing company is developing an offering to their customers that is focused on the utility of their products throughout their life time. The paper describes the process of how a company...

  13. Canadian accelerator breeder system development

    A shortage of fissile material at a reasonable price is expected to occur in the early part of the twenty-first century. Converting fertile material to fissile material by electronuclar methods is an option that can extend th world's resources of fissionable material, supplying fuel for nuclear power stations. This paper presents the rationale for electronuclear breeders and describes the Canadian development program for an accelerator breeder facility that could produce 1 Mg of fissile material per year

  14. End-expiration Respiratory Gating for a High Resolution Stationary Cardiac SPECT system

    Chan, Chung; Harris, Mark; Le, Max; Biondi, James; Grobshtein, Yariv; Liu, Yi-Hwa; Sinusas, Albert J.; Liu, Chi

    2014-01-01

    Respiratory and cardiac motions can degrade myocardial perfusion SPECT (MPS) image quality and reduce defect detection and quantitative accuracy. In this study, we developed a dual-respiratory and cardiac gating system for a high resolution fully stationary cardiac SPECT scanner in order to improve the image quality and defect detection. Respiratory motion was monitored using a compressive sensor pillow connected to a dual respiratory-cardiac gating box, which sends cardiac triggers only duri...

  15. Development of a diagnostic expert system for PWR feedwater system

    The feedwater system of a PWR plays an important role in normal plant operation and safety control under transient conditions and even a minor abnormality in this system may have a significant impact on the plant's operational integrity. So, the plant operator and maintenance staff must be knowledgeable about the feedwater system and the development of an expert system to support plant staff is desirable. A diagnostic expert system for PWR feedwater systems has been developed. As a first step, prototype system software for off-line diagnosis was developed. The essential functions of this system are to identify defective components and provide specific guidance for repair when an abnormality of the feedwater system occurs during plant operation. The paper presents a system configuration, methodology for diagnosis, results of test runs and evaluation for a prototype system. (author). Poster presentation. 1 ref., 3 figs

  16. CATALYTIC COMBUSTION COMPONENT AND SYSTEM PROTOTYPE DEVELOPMENT

    The report gives results of a project to develop the components required for catalytic combustion system operation and evaluation. The systems investigated (firetube boiler, watertube boiler, and gas turbine), when integrated with the catalytic combustor, have potential for both ...

  17. The development of wireless area monitoring system

    A wireless monitoring system was developed in the Fugen nuclear power station to measure the dose rate changes of radiation working areas in the reactor building. The system provided real time information to operators during the chemical decontamination campaign performed in 1989 and 1991. The system markedly reduced occupational radiation dose with manual dose rate monitoring. Development history of the system and benefits provided are described. (author)

  18. Mobile Application Development: Component Retrieval System Project

    National Aeronautics and Space Administration — The proposed technology development concept is a software application tool developed for use on a mobile device at SSC for use in the component retrieval system...

  19. Risks in Information Systems Development Projects

    Lazar Raković; Ozren Đurković

    2009-01-01

    Risk is a part of all aspects of everyday life. Development of an informational system is a complex process, which makes it submissive to a great number of risks. Many projects do not achieve previously set goals, therefore risk management is not to be ignored in the development of informational systems. In this paper, the efficacy of IS development, as well as a number of risks influencing the project development, are considered. Also, attention is paid to the risk management methodology, si...

  20. Autonomous Systems Developments and Trends

    Kyamaky, Kyandoghere; Kacprzyk, Janusz

    2012-01-01

    The Workshops on Autonomous Systems emanated from a gathering with the doctoral students of just three chairs at Fernuniversität in Hagen, which we organise twice per year for a number of years now. Their purpose is to discuss on-going research and to create a community spirit. Furthermore, they serve as a means of structuring the students' research processes. The workshop has grown and matured in several respects. The doctoral students presenting their work do not come from a single university anymore, but from three. Besides them and their supervisors, also other scientists became interested in the event and contribute to its programme. Following the model of Advanced Study Institutes, they are available on the premises for relaxed, informal discussions outside the formal sessions. Finally, with the co-sponsorship of Gesellschaft für Informatik, the German Computer Society, and this surprisingly comprehensive volume of contributions published by Springer-Verlag the workshop turned into a visible scientifi...

  1. Safeguards -Safeguards system development support-

    This project mainly focused to technically support national safeguards inspection which is scheduled in the beginning of 1997. It includes non-destructive assay of nuclear fuels, analysis on inspection and environmental samples, remote monitoring of nuclear activities and its analysis, survey on remote sensing of satellite for safeguards application. Non-destructive assay of nuclear fuels dealt with development on verification of spent fuels with emphasis to fabrication of inspection tools with surveillance and gamma measurement on CANDU spent fuels. For sample analysis, study was carried out on process inspection sample analysis method. In addition to this, ultra low background laboratory was set up to execute environmental and swipe samples and sample treatment techniques including water, soil, plant, et al. were researched. Tritiums which were sampled around power plants were analysed. With cooperation of Satellite Technology Research Center of KAIST, use of civilian satellite imagery was surveyed. To train facility operators for safeguards, various technology on non-destructive assay was lectured to personnel of Korea Electric Power Corporation. And to enhance out capabilities, non-destructive assay training was done at Los Alamos National Lab. of U.S. through the agreement of MOST and DOE agreement, and information on DA technology was exchanged at Nuclear Material Control Center of Japan. (author). 22 tabs., 52 figs., 53 refs

  2. Elements of a successful safeguards system development

    The material control and accounting system in place in the nuclear fuel facility of the General Electric Wilmington Manufacturing Department has received national and international recognition as one of the best in the nuclear industry. Although only low enriched uranium is processed in the facility, the system has been identified as a model Material Control and Accounting tool capable of handling safeguards requirements applicable to high enriched uranium processing. The development of the system can also serve as a model for other systems, and this report is essentially a ''how to'' description of the GE experience. Important facets of the system development included actions taken to enhance input data accuracy, the diversity and depth in experience of the development team, the adequacy of the resources committed to development, and top management support of the project. Most provocative was the concept of the need for an integrated manufacturing information system rather than a safeguards system per se

  3. The MAGLEV bogie system and its development

    Seino, Hiroshi [Railway Technical Research Inst., Maglev Systems Development Dept., Vehicle Engineering Div., Tokyo (Japan); Kato, Ken-ichi [Railway Technical Research Inst., Maglev Systems Development Dept., Vehicle Engineering Div., Tokyo (Japan); Oshima, Hiroshi [Central Japan Railway Co., Tokyo (Japan). Linear Express Development Div.; Azakami, Masayoshi [Railway Technical Research Inst., Maglev Systems Development Dept., Vehicle Engineering Div., Tokyo (Japan); Yoshioka, Hiroshi [Maglev Systems Technology Lab., Tokyo (Japan)

    1995-12-31

    A new Japan Railways (JR) MAGLEV vehicle was completed in the spring of this year, and the MAGLEV system is now being assembled and prepared on the Yamanashi test line. The completed vehicle consists of the `conventional MAGLEV bogie system`, with rigidly fitted on-board superconducting magnets (SCM). Meanwhile, the new concept of the `SCM resiliently-mounting method` and its controlling system have been continued to be studied and developed for the `new MAGLEV bogie system` on the Miyazaki test track since 1989. The `resiliently mounted SCM bogie system` is being developed and studied for the purpose of riding comfort in the sidewall levitation MAGLEV system, and valuable data were obtained from running tests on the Miyazaki test track. The bogie system for the second train set on the Yamanashi test line will adopt the `SCM resiliently-mounting method`. In this paper, the development of the JR MAGLEV bogie system and its properties are reported. (orig.)

  4. Development of work management prototype system

    In order to keep high safety, availability and economy at a nuclear power station, an advanced and automatic system has been required in the field of operation and maintenance management as well as plant operation, supervision and control. As the first step in system development, the work management support prototype system was built, verified and evaluated. It has been confirmed that the system can be usefully applied to the actual field. The system function and configuration is hereinafter described. (author)

  5. Development of Architectures for Internet Telerobotics Systems

    Bambang, Riyanto

    2008-01-01

    This paper presents our experience in developing and implementing Internet telerobotics system. Internet telerobotics system refers to a robot system controlled and monitored remotely through the Internet. A robot manipulator with five degrees of freedom, called Mentor, is employed. Client-server architecture is chosen as a platform for our Internet telerobotics system. Three generations of telerobotics systems have evolved in this research. The first generation was based on CGI and two tiere...

  6. Interactive Development Environments for Information Systems

    Wasserman, Anthony I.

    1986-01-01

    Most medical information systems are interactive information systems, since they provide their users with conversational access to data. The design of an interactive information system requires attention to data design, process design, and user interface design so that the resulting system will be easy to use and reliable. This paper describes some automated tools aimed at assisting software designers and developers in creating interactive information systems, with emphasis on the Software th...

  7. A Social Ontology for Information System Development

    Kolp, Manuel; Giorgini, Palolo

    2002-01-01

    Organizations are changing at an ever-faster pace, as they try to keep up with globalization and the information revolution. Unfortunately, information systems technologies do not support system evolution well, making information systems a roadblock to i* organizational change. We propose to view information systems as social structures and define methodologies which develop and evolve seamlessly an information system within its operational environment. To this end, this paper proposes an ont...

  8. Factors Affecting the Adoption of Mobile Payment Systems: An Empirical Analysis

    İkram Daştan

    2016-02-01

    Full Text Available The world witnessed a rapid growth in the e-commerce in the recent years. Widespread use of mobile devices in the e-commerce has a role in this augmentation. Associated with growth of trading volume and the introduction of new devices, new products and solutions emerge and they diversify concerning online payments. Consumer attitudes and behaviors may change according to these developments. The purpose of this study is to investigate the factors effecting adoption of mobile payment systems by the consumer. 225 individuals were surveyed online through convenience sampling method. A research model was developed and proposed relationships were tested using structural equation modeling. The empirical findings point out that perceived trust, perceived mobility and attitudes positively affect the adoption of MPS; perceived usefulness and perceived ease of use have no effect on adoption of MPS. Furthermore perceived reputation positively related to perceived trust and finally environmental risk negatively related to perceived trust.

  9. Notes on innovation systems and economic development

    Lundvall, Bengt-Åke

    2011-01-01

    This paper gives a brief history and background for the concept 'national innovation system' and discusses its usefulness for understanding and managing economic development.......This paper gives a brief history and background for the concept 'national innovation system' and discusses its usefulness for understanding and managing economic development....

  10. The hairpin region of Ndc80 is important for the kinetochore recruitment of Mph1/MPS1 in fission yeast.

    Chmielewska, Aldona Ewa; Tang, Ngang Heok; Toda, Takashi

    2016-03-01

    The establishment of proper kinetochore-microtubule attachments facilitates faithful chromosome segregation. Incorrect attachments activate the spindle assembly checkpoint (SAC), which blocks anaphase onset via recruitment of a cohort of SAC components (Mph1/MPS1, Mad1, Mad2, Mad3/BubR1, Bub1 and Bub3) to kinetochores. KNL1, a component of the outer kinetochore KMN network (KNL1/Mis12 complex/Ndc80 complex), acts as a platform for Bub1 and Bub3 localization upon its phosphorylation by Mph1/MPS1. The Ndc80 protein, a major microtubule-binding site, is critical for MPS1 localization to the kinetochores in mammalian cells. Here we characterized the newly isolated mutant ndc80-AK01 in fission yeast, which contains a single point mutation within the hairpin region. This hairpin connects the preceding calponin-homology domain with the coiled-coil region. ndc80-AK01 was hypersensitive to microtubule depolymerizing reagents with no apparent growth defects without drugs. Subsequent analyses indicated that ndc80-AK01 is defective in SAC signaling, as mutant cells proceeded into lethal cell division in the absence of microtubules. Under mitotic arrest conditions, all SAC components (Ark1/Aurora B, Mph1, Bub1, Bub3, Mad3, Mad2 and Mad1) did not localize to the kinetochore. Further genetic analyses indicated that the Ndc80 hairpin region might act as a platform for the kinetochore recruitment of Mph1, which is one of the most upstream SAC components in the hierarchy. Intriguingly, artificial tethering of Mph1 to the kinetochore fully restored checkpoint signaling in ndc80-AK01 cells, further substantiating the notion that Ndc80 is a kinetochore platform for Mph1. The hairpin region of Ndc80, therefore, plays a critical role in kinetochore recruitment of Mph1. PMID:26900649

  11. Injecting security into information systems development

    Lapke, Michael

    2010-01-01

    This paper will attempt to reconcile the apparent developmental duality (Baskerville, 1992) between Information Systems (IS) development and IS security development. IS Development and IS Security Development each have a substantial foundation of literature on their respective approaches and methodologies. livari, Hirschheim and Klein (2001) provide a dynamic framework for classifying IS development approaches and methodologies. Besides providing a method for classification, this framework de...

  12. Testing Infrastructure for Operating System Kernel Development

    Walter, Maxwell; Karlsson, Sven

    2014-01-01

    Testing is an important part of system development, and to test effectively we require knowledge of the internal state of the system under test. Testing an operating system kernel is a challenge as it is the operating system that typically provides access to this internal state information. Multi...... obtain information about the system. We have also developed an in-kernel testing API that we can use to develop a suite of unit tests in the kernel. We are using our framework for for the development of our own multi-core research kernel.......-core kernels pose an even greater challenge due to concurrency and their shared kernel state. In this paper, we present a testing framework that addresses these challenges by running the operating system in a virtual machine, and using virtual machine introspection to both communicate with the kernel and...

  13. Development of Residential SOFC Cogeneration System

    Since 2001 Kyocera has been developing 1kW class Solid Oxide Fuel Cell (SOFC) for power generation system. We have developed a cell, stack, module and system. Since 2004, Kyocera and Osaka Gas Co., Ltd. have been developed SOFC residential co-generation system. From 2007, we took part in the 'Demonstrative Research on Solid Oxide Fuel Cells' Project conducted by New Energy Foundation (NEF). Total 57 units of 0.7kW class SOFC cogeneration systems had been installed at residential houses. In spite of residential small power demand, the actual electric efficiency was about 40%(netAC,LHV), and high CO2 reduction performance was achieved by these systems. Hereafter, new joint development, Osaka Gas, Toyota Motors, Kyocera and Aisin Seiki, aims early commercialization of residential SOFC CHP system.

  14. Development of Residential SOFC Cogeneration System

    Ono, Takashi; Miyachi, Itaru; Suzuki, Minoru; Higaki, Katsuki

    2011-06-01

    Since 2001 Kyocera has been developing 1kW class Solid Oxide Fuel Cell (SOFC) for power generation system. We have developed a cell, stack, module and system. Since 2004, Kyocera and Osaka Gas Co., Ltd. have been developed SOFC residential co-generation system. From 2007, we took part in the "Demonstrative Research on Solid Oxide Fuel Cells" Project conducted by New Energy Foundation (NEF). Total 57 units of 0.7kW class SOFC cogeneration systems had been installed at residential houses. In spite of residential small power demand, the actual electric efficiency was about 40%(netAC,LHV), and high CO2 reduction performance was achieved by these systems. Hereafter, new joint development, Osaka Gas, Toyota Motors, Kyocera and Aisin Seiki, aims early commercialization of residential SOFC CHP system.

  15. Development of sorting system control using LABVIEW

    The development of the Personnel Dosimeter Sorting System, proposed by the Secondary Standard Dosimetry Laboratory (SSDL) is to enhance the system or work flow in preparing the personnel dosimeter. The main objective of the system is to reduce stamping error, time and cost. The Personnel Dosimeter Sorting System is a semi-automatic system with an interfacing method using the Advantec 32 bit PCI interface card of 64 digital input and output. The system is integrated with the Labview version 7.1 programming language to control the sorting system and operation. (Author)

  16. Solar heating and cooling systems design and development. [prototype development

    1977-01-01

    The development of twelve prototype solar heating/cooling systems, six heating and six heating and cooling systems, two each for single family, multi-family, and commercial applications, is reported. Schedules and technical discussions, along with illustrations on the progress made from April 1, 1977 through June 30, 1977 are detailed.

  17. Enterprise ontology based development of information systems

    Antonia Albani; Jan L. G. Dietz

    2011-01-01

    For the development of enterprise information systems, the utilisation of a suitable methodology is essential, providing necessary methods and techniques for modelling the business domain and for designing the supporting information systems. Several methodologies exist and are widely applied in practice nowadays, but most of them lack a theoretical foundation. In this paper, we demonstrate an information system development methodology based on the notions of enterprise ontology and business c...

  18. Toward the Development of Expert Assessment Systems.

    Hasselbring, Ted S.

    1986-01-01

    The potential application of "expert systems" to the diagnosis and assessment of special-needs children is examined and existing prototype systems are reviewed. The future of this artificial intelligence technology is discussed in relation to emerging development tools designed for the creation of expert systems by the lay public. (Author)

  19. Recent development of cellular manufacturing systems

    P K Arora; A Haleem; M K Singh

    2013-06-01

    Cellular manufacturing system has been proved a vital approach for batch and job shop production systems. Group technology has been an essential tool for developing a cellular manufacturing system. The paper aims to discuss various cell formation techniques and highlights the significant research work done in past over the years and attempts to points out the gap in research.

  20. Developing Sustainable Life Support System Concepts

    Thomas, Evan A.

    2010-01-01

    Sustainable spacecraft life support concepts may allow the development of more reliable technologies for long duration space missions. Currently, life support technologies at different levels of development are not well evaluated against each other, and evaluation methods do not account for long term reliability and sustainability of the hardware. This paper presents point-of-departure sustainability evaluation criteria for life support systems, that may allow more robust technology development, testing and comparison. An example sustainable water recovery system concept is presented.

  1. Management Planning for Library Systems Development

    Bellomy, Fred L.

    2013-01-01

    This paper deals with the application to library systems development programs of planning techniques which long ago proved their usefulness in business, military, and aerospace developments. The significant features of PERT (Program Evaluation and Review Technique), WBS (Work Breakdown Structure), planning diagrams, statements of work, cost/time estimates, schedules, manpower loading, and cost phasing are related through an example to the management requirements of a mafor systems development...

  2. MSFC Lunar Environments Test System (LETS) System Development

    Craven, Paul; Vaughn, Jason; Schneider, Todd; Norwood, Joey; Abbas, Mian; Alexander, Reginald

    2009-01-01

    A review of the NASA MSFC Lunar Environment Test System (LETS) System Development is presented. The contents include: 1) MSFC LETS Chamber Status; 2) LETS Simulant Containment Box Development; 3) Tests Conducted in LETS To date: Simulant Dust Migration; 4) Summary; and 5) Forward Work.

  3. Testing Infrastructure for Operating System Kernel Development

    Walter, Maxwell; Karlsson, Sven

    2014-01-01

    Testing is an important part of system development, and to test effectively we require knowledge of the internal state of the system under test. Testing an operating system kernel is a challenge as it is the operating system that typically provides access to this internal state information. Multi-core kernels pose an even greater challenge due to concurrency and their shared kernel state. In this paper, we present a testing framework that addresses these challenges by running the operating sy...

  4. Psychology of developing and designing expert systems

    Tonn, B.; MacGregor, D.

    1986-01-01

    This paper discusses psychological problems relevant to developing and designing expert systems. With respect to the former, the psychological literature suggests that several cognitive biases may affect the elicitation of a valid knowledge base from the expert. The literature also suggests that common expert system inference engines may be quite inconsistent with reasoning heuristics employed by experts. With respect to expert system user interfaces, care should be taken when eliciting uncertainty estimates from users, presenting system conclusions, and ordering questions.

  5. Recent Developments on Chaos in Mechanical Systems

    Mohammad Sajid

    2013-01-01

    Recent advancements in complexity of mechanical systems have led to the application of chaos theory. In this paper, some recent developments on chaos in mechanical systems are explored. The aim is to bring together researchers from various interests of mechanical systems, exposing them to chaos theory. This exposure gives researchers from the discipline of mechanical systems to find opportunity of cross disciplinary research, which may ultimately lead to novel solutions and understanding of m...

  6. Systems Engineering Leadership Development: Advancing Systems Engineering Excellence

    Hall, Phil; Whitfield, Susan

    2011-01-01

    This slide presentation reviews the Systems Engineering Leadership Development Program, with particular emphasis on the work being done in the development of systems engineers at Marshall Space Flight Center. There exists a lack of individuals with systems engineering expertise, in particular those with strong leadership capabilities, to meet the needs of the Agency's exploration agenda. Therefore there is a emphasis on developing these programs to identify and train systems engineers. The presentation reviews the proposed MSFC program that includes course work, and developmental assignments. The formal developmental programs at the other centers are briefly reviewed, including the Point of Contact (POC)

  7. System model development for nuclear thermal propulsion

    A critical enabling technology in the evolutionary development of nuclear thermal propulsion (NTP) is the ability to predict the system performance under a variety of operating conditions. Since October 1991, US (DOE), (DOD) and NASA have initiated critical technology development efforts for NTP systems to be used on Space Exploration Initiative (SEI) missions to the Moon and Mars. This paper presents the strategy and progress of an interagency NASA/DOE/DOD team for NTP system modeling. It is the intent of the interagency team to develop several levels of computer programs to simulate various NTP systems. An interagency team was formed for this task to use the best capabilities available and to assure appropriate peer review. The vision and strategy of the interagency team for developing NTP system models will be discussed in this paper. A review of the progress on the Level 1 interagency model is also presented

  8. Development of an autonomous power system testbed

    A power system testbed has been assembled to advance the development of large autonomous electrical power systems required for the space station, spacecraft, and aircraft. The power system for this effort was designed to simulate single- or dual-bus autonomous power systems, or autonomous systems that reconfigure from a single bus to a dual bus following a severe fault. The approach taken was to provide a flexible power system design with two computer systems for control and management. One computer operates as the control system and performs basic control functions, data and command processing, charge control, and provides status to the second computer. The second computer contains expert system software for mission planning, load management, fault identification and recovery, and sends load and configuration commands to the control system

  9. Space Launch Flight Termination System initial development

    Ratkevich, B.; Brierley, S.; Lupia, D.; Leiker, T.

    This paper describes the studies, capabilities and challenges in initial development of a new digital encrypted termination system for space launch vehicles. This system is called the Space Launch Flight Termination System (SLFTS). Development of SLFTS is required to address an obsolescence issue and to improve the security of flight termination systems presently in use on the nation's space launch vehicles. SLFTS development was implemented in a four phase approach with the goal of producing a high secure, cost effective flight termination system for United Launch Alliance (ULA) and the United States Air Force (USAF) Evolved Expendable Launch Vehicle (EELV). These detailed study phases developed the requirements, design and implementation approach for a new high secure flight termination system. Studies led to a cost effective approach to replace the High Alphabet Command Receiver Decoders (HA-CRD) presently used on the EELV (Delta-IV & Atlas-V), with a common SLFTS unit. SLFTS is the next generation flight termination system for space launch vehicles, providing an assured high secure command destruct system for launch vehicles in flight. The unique capabilities and challenges to develop this technology for space launch use will be addressed in this paper in detail. This paper summarizes the current development status, design and capabilities of SLFTS for EELV.

  10. A Software Development Platform for Mechatronic Systems

    Guan, Wei

    Software has become increasingly determinative for development of mechatronic systems, which underscores the importance of demands for shortened time-to-market, increased productivity, higher quality, and improved dependability. As the complexity of systems is dramatically increasing, these demands...... present a challenge to the practitioners who adopt conventional software development approach. An effective approach towards industrial production of software for mechatronic systems is needed. This approach requires a disciplined engineering process that encompasses model-driven engineering and component......-based software engineering, whereby we enable incremental software development using component models to address the essential design issues of real-time embedded systems. To this end, this dissertation presents a software development platform that provides an incremental model-driven development process based...

  11. Development of intelligent operation control system

    Power Reactor and Nuclear Fuel Development Corp. participates in the developments of an intelligent operation control system (IOCS) and an intelligent maintenance control system (IMCS) for automatic operation and maintenance of nuclear power plant. The present situations and perspectives of these developments and researches were reviewed. In the period of 1991-1995, development of a prototype system for the assessment of the availability of IOCS ws tried and a plant diagnosis system based on a hierarchical function model and a control of plant operation according to a hierarchically operating strategy model were introduced. An object-oriented multi-agent system was applied to develop the IOCS consisting of subsystems in four levels and a man-machine interface able to display the operating conditions of those subsystems for operating managers was equipped to this system. The functions of each subsystem were evaluated by building block typed simulator. Aiming to construct some test systems we have a plan to materialize the processing algorithm and a system for each functional agent and also to establish a system to coordinate the respective agents. (M.N.)

  12. Space Shuttle Main Propulsion System Anomaly Detection: A Case Study

    National Aeronautics and Space Administration — The space shuttle main engine (SSME) is part of the Main Propnlsion System (MPS) which is an extremely complex system containing several sub-systems and components,...

  13. Development of the Digital Reactor Safety System

    Objectives of Project - Development of Digital Safety Grade PLC and Licensing - Development of Safety System(RPS) and Licensing - Development of Safety System(ESF-CCS) and Licensing Content and Result of Project - POSAFE-Q PLC : Development of PLC platform for Shin-UCN unit 1 and 2 ·Development Scope : Processor module, Power module, 3 kinds of Communication module, Bus extension module(Master and Slave), 16 kinds of Input and Output module ·PLC application software development tool(pSET) - IDiPS RPS and IDiPS ESF-CCS : Development of PPS for Sin-UCN 1 and 2 ·Development Scope - 4-channels RPS with the KNICS inherent architecture - A part of 1-channels ESF-CCS with the KNICS inherent architecture - Licensing ·optical Report Submitted and Expected to finish the licensing process until Aug. 2008

  14. Systems Biology Approach to DevelopingSystems Therapeutics”

    Maguire, Greg

    2014-01-01

    The standard drug development model uses reductionist approaches to discover small molecules targeting one pathway. Although systems biology analyzes multiple pathways, the approach is often used to develop a small molecule interacting at only one pathway in the system. Similar to that in physics where a departure from the old reductionist “Copenhagen View” of quantum physics to a new and predictive systems based, collective model has emerged yielding new breakthroughs su...

  15. Development of environment radiation database management system

    Kang, Jong Gyu; Chung, Chang Hwa; Ryu, Chan Ho; Lee, Jin Yeong; Kim, Dong Hui; Lee, Hun Sun [Daeduk College, Taejon (Korea, Republic of)

    1999-03-15

    In this development, we constructed a database for efficient data processing and operating of radiation-environment related data. Se developed the source documents retrieval system and the current status printing system that supports a radiation environment dta collection, pre-processing and analysis. And, we designed and implemented the user interfaces and DB access routines based on WWW service policies on KINS Intranet. It is expected that the developed system, which organizes the information related to environmental radiation data systematically can be utilize for the accurate interpretation, analysis and evaluation.

  16. The Development of Oromo Writing System

    Degeneh Bijiga, Teferi

    2015-01-01

    The development and use of languages for official, education, religion, etc. purposes have been a major political issue in many developing multilingual countries. A number of these countries, including China and India, have recognised the issues and developed language policies that have provided some ethnic groups with the right to develop their languages and cultures by using writing systems based on scripts suitable for these purposes. On the other hand, other countries, such as Ethiopia (a...

  17. Communication challenges in system development: involvement of system developers in small-scale IT projects.

    Petersen, Lone Stub; Bjoernes, Charlotte D; Bertelsen, Pernille

    2010-01-01

    A well-known challenge in system development is the aspect of user participation. In this paper we shift perspective from how to involve users in system development to how project managers with a clinical background, but without technical system knowledge, can involve system developers in IT projects. Using data from the development of an online patient book (an ICT application for clinical practice), we analyze challenges using the concept of language-games. We conclude that further research and development of participatory and communicative methods to involve system developers in IT projects, based in a clinical context, is needed. PMID:20543370

  18. Appendix E: Parallel Pascal development system

    1985-01-01

    The Parallel Pascal Development System enables Parallel Pascal programs to be developed and tested on a conventional computer. It consists of several system programs, including a Parallel Pascal to standard Pascal translator, and a library of Parallel Pascal subprograms. The library includes subprograms for using Parallel Pascal on a parallel system with a fixed degree of parallelism, such as the Massively Parallel Processor, to conveniently manipulate arrays which have dimensions than the hardware. Programs can be conveninetly tested with small sized arrays on the conventional computer before attempting to run on a parallel system.

  19. Development of control system for measuring system with CAMAC

    Construction of a large-scale helical device equipped with many measuring instruments is progressing in National Institute for Fusion Science. Aiming at the development of a control system using CAMAC, HIBP measuring system equipped with CHS experimental system was chosen as the object. It is necessary to operate all parts of the apparatus by remote-control. However, there are various functions necessary for the control system of those measuring equipments. Possibly, some of those functions such as those in the vacium-exhaust system can be controlled by a common system. The authors attempted to develop a control system composed of CAMAC controlled by an intelligent crate-controller, and a programmable logic one. In this report, this system, CAMAC and the latter controller are assigned to the real-time control of beam-orbital and the sequence control of the vacuum-exhaust apparatus, respectively. The real-time OS of the intelligent crate controller along with the above system is explained in this report. Further, development of an environment is which graphical user interface available for general-purpose net works is usable and also of a development of measuring control system with VME + VxWorks as well as CAMAC + VAXELN for comparison of the respective control systems are pointed out as the future problems. (M.N.)

  20. Highly reusability surface loaded metal particles magnetic catalyst microspheres (MCM-MPs) for treatment of dye-contaminated water

    Liu, Ying; Zhang, Kun; Yin, Xiaoshuang; Yang, Wenzhong; Zhu, Hongjun

    2016-04-01

    The metal-deposited magnetic catalyst microspheres (MCM-MPs) were successfully synthesized by one facile, high yield and controllable approach. Here, the bare magnetic microspheres were firstly synthesized according to the solvothermal method. Then silica shell were coated on the surface of the magnetic microspheres via sol-gel method, and subsequently with surface modifying with amino in the purpose to form SiO2-NH2 shell. Thus, metal particles were easily adsorbed into the SiO2-NH2 shell and in-situ reduced by NaBH4 solution. All the obtained products (MCM-Cu, MCM-Ag, MCM-Pd) which were monodisperse and constitutionally stable were exhibited high magnetization and excellent catalytic activity towards dyes solution reduction. The catalytic rate ratio of MCM-Pd: MCM-Cu: MCM-Ag could be 10:3:1. Besides, some special coordination compound Cu2(OH)3Br had been generated in the in-situ reduced process of MCM-Cu, which produced superior cyclical stability (>20 times) than that of MCM-Ag and MCM-Pd. In all, those highly reusability and great catalytic efficiency of MCM-MPs show promising and great potential for treatment of dye-contaminated water.

  1. Clinical Analysis about Diagnosis and Treatment of 86 Hand Paresthesia Cases Using MPS Theory and Pharmacopuncture Therapy

    Sung-Won Oh

    2007-12-01

    Full Text Available Objectives : Hand paresthesia is common syndrome and the cause is more unknown than known reason. The Purpose of this study were investigated the effects of Myofacial Pain Syndrome theory to make diagnosis and treatment by Pharmacopuncture for the patients of hand paresthesia. Method : This study was carried out to established the clinical criteria of hand parethesia. The patients who had past history of diabeics, neuropathy induced by alcohol or drug were excluded, and 86 patients who had hand paresthesia related with unknown-reason was selected by the interview process. And the effects of Pharmacopuncture theory were analyzed using VAS score before and after treatment. Results and conclusions : 56.9% of unknown-reason patients are positive at diagnosis by MPS theory. While positive group decrease from 62.81±14.27 to 25.28±15.97, negative group decrease from 55.88±10.92 to 48.28±14.01 by VAS scores. Positive group was accordingly more effective than negative group. So diagnosis and treatment for hand numbness patients by MPS theory was useful in clinical.

  2. Investigation of current transport parameters of Ti/4H-SiC MPS diode with inhomogeneous barrier

    The current transport parameters of 4H-SiC merged PiN Schottky (MPS) diode are investigated in a temperature range of 300520 K. Evaluation of the experimental currentvoltage (IV) data reveals the decrease in Schottky barrier height ?b but an increase in ideality factor n, with temperature decreasing, which suggests the presence of an inhomogeneous Schottky barrier. The current transport behaviours are analysed in detail using the Tung's model and the effective area of the low barrier patches is extracted. It is found that small low barrier patches, making only 4.3% of the total contact, may significantly influence the device electrical characteristics due to the fact that a barrier height of 0.968 eV is much lower than the average barrier height 1.39 eV. This shows that ion implantation in the Schottky contact region of MPS structure may result in a poor Ti/4H-SiC interface quality. In addition, the temperature dependence of the specific on-resistance (Ronsp), T2.14, is determined between 300 K and 520 K, which is similar to that predicted by a reduction in electron mobility. (condensed matter: electronic structure, electrical, magnetic, and optical properties)

  3. Research and Development Information System (RDIS)

    Department of Veterans Affairs — The Research and Development Information System (RDIS) is the Veterans Affairs Central Office budgetary and project data repository for managing the VA Research and...

  4. Progress in the Development of Nanotheranostic Systems

    Cui, Honggang; Wang, Jun

    2016-01-01

    This thematic issue includes both review and research articles and is intended to provide an overview on the recent progress in the development of nanostructure-based therapeutic, diagnostic, and theranostic systems. PMID:27217827

  5. On Using Materiality in Information Systems Development

    Carugati, Andrea

    This research brief presents a discussion on the use of the concept of materiality and material knowing in information systems development (ISD). The discussion addresses some of the practical problems still plaguing ISD, augmenting existing ISD methodologies with contributions from systems theory...... and in particular the idea of inquiring systems. The discussion builds on different contemporary concepts that are rooted in the inquiring systems idea: the notion of stakeholders (designer, client, user and their interchanging roles), the notion boundary object and boundary spanners, and the notion...... of materiality as scaffold of knowledge. Through the example taken from a case study of a complex and innovative systems development we outline two design principles to be embedded in modular fashion in ISD processes: (1) whenever possible start ISD efforts by developing a graphical simulator of the...

  6. Development of Architectures for Internet Telerobotics Systems

    Bambang, Riyanto

    2008-01-01

    This paper presents our experience in developing and implementing Internet telerobotics system. Internet telerobotics system refers to a robot system controlled and monitored remotely through the Internet. A robot manipulator with five degrees of freedom, called Mentor, is employed. Client-server architecture is chosen as a platform for our Internet telerobotics system. Three generations of telerobotics systems have evolved in this research. The first generation was based on CGI and two tiered architecture, where a client presents a Graphical User Interface to the user, and utilizes the user's data entry and actions to perform requests to robot server running on a different machine. The second generation was developed using Java. We also employ Java 3D for creating and manipulating 3D geometry of manipulator links and for constructing the structures used in rendering that geometry, resulting in 3D robot movement simulation presented to the users(clients) through their web browser. Recent development in our In...

  7. Usability Factors in Information Systems Development

    K. Chandra Sekharaiah

    2014-07-01

    Full Text Available Computers have become a commonplace technology for today’s man. Computer users demand more reliable and durable interfaces from information processing applications developers. Information systems (ISs research and development, over the years, has been steady so well that the arena has now grown into various subfields such as Cognitive Information Systems (CISs, Web Information Systems(WISs, Geographical Information Systems(GISs, Enterprise Information Systems (EISs, and so forth. Of late, ergonomics specialization too has begun to percolate into the field making it more cross-fertilizing with concerns for successful deployment, a win-win model of development and look-and-feel factor in terms of durable usage and usability. The paper presents a novel taxonomy of computer ergonomics.

  8. Some features of geometrical modeling system development

    Kurennov, Dmitry

    2015-11-01

    The description of data structure for the description of geometrical three-dimensional object model is presented in the paper. Use of such data structure allows to develop algorithms of models creation for complex geometrical objects. The present possibility has essential value at creation of geometrical modeling system which can form a basis for development of specialized systems of automation, for example, of design and technological preparation of production.

  9. Work values system development during adolescence

    Porfeli, Erik J.

    2007-01-01

    Work values stability, change, and development can be appreciably reduced to a living system model (Ford, 1994). This theoretical model includes discrepancy-reducing and cohesion-amplifying mechanisms that interact to govern the change in standard- and goal-oriented work values over time (Boldero & Francis, 2002). Employing longitudinal data from a sample of adolescents (n = 1010) spanning the 9th through the 12th grades, the results demonstrate that the value system develops in a theoretical...

  10. Toward a Cooperative Experimental System Development Approach

    Grønbæk, Kaj; Kyng, Morten; Mogensen, Preben Holst

    targeted object oriented design, specification, and realisation; and design for tailorability. The emerging CESD approach is based on several years of experience in applying cooperative analysis and design techniques in projects developing general, tailorable software products. The CESD approach is......This chapter represents a step towards the establishment of a new system development approach, called Cooperative Experimental System Development (CESD). CESD seeks to overcome a number of limitations in existing approaches: specification oriented methods usually assume that system design can be....../design activities of development projects. In contrast, the CESD approach is characterized by its focus on: active user involvement throughout the entire development process; prototyping experiments closely coupled to work-situations and use-scenarios; transforming results from early cooperative analysis/design to...

  11. Hydrogen storage and delivery system development: Fabrication

    Handrock, J.L.; Malinowski, M.E.; Wally, K. [Sandia National Lab., Livermore, CA (United States)

    1996-10-01

    Hydrogen storage and delivery is an important element in effective hydrogen utilization for energy applications and is an important part of the FY1994-1998 Hydrogen Program Implementation Plan. This project is part of the Field Work Proposal entitled Hydrogen Utilization in Internal Combustion Engines (ICE). The goal of the Hydrogen Storage and Delivery System Development Project is to expand the state-of-the-art of hydrogen storage and delivery system design and development. At the foundation of this activity is the development of both analytical and experimental evaluation platforms. These tools provide the basis for an integrated approach for coupling hydrogen storage and delivery technology to the operating characteristics of potential hydrogen energy use applications. Analytical models have been developed for internal combustion engine (ICE) hybrid and fuel cell driven vehicles. The dependence of hydride storage system weight and energy use efficiency on engine brake efficiency and exhaust temperature for ICE hybrid vehicle applications is examined. Results show that while storage system weight decreases with increasing engine brake efficiency energy use efficiency remains relatively unchanged. The development, capability, and use of a newly developed fuel cell vehicle hydride storage system model will also be discussed. As an example of model use power distribution and control for a simulated driving cycle is presented. An experimental test facility, the Hydride Bed Testing Laboratory (HBTL) has been designed and fabricated. The development of this facility and its use in storage system development will be reviewed. These two capabilities (analytical and experimental) form the basis of an integrated approach to storage system design and development. The initial focus of these activities has been on hydride utilization for vehicular applications.

  12. Developing a system for AMB Monitoring

    Hancock, Thomas

    2015-01-01

    A monitoring system for the Associative Memory Boards (AMBs) of the Fast Tracker (FTK) is developed and tested. This system is able to read out status register values from AMBs and publish them to the Information Service (IS). The system is designed so as to be easily extensible to other boards of FTK, and this is demonstrated through an extension of the systems to be able to monitor FTK Auxiliary cards. Future work will involve extensions to other FTK boards and providing a system to read from IS and present the user with the monitoring data.

  13. System analysis: Developing tools for the future

    De Jong, K.; clever, J.; Draper, J.V.; Davies, B.; Lonks, A.

    1996-02-01

    This report introduces and evaluates system analysis tools that were developed, or are under development, for the Robotics Technology Development Program (RTDP). Additionally, it discusses system analysis work completed using these tools aimed at completing a system analysis of the retrieval of waste from underground storage tanks on the Hanford Reservation near Richland, Washington. The tools developed and evaluated include a mixture of commercially available tools adapted to RTDP requirements, and some tools developed in house. The tools that are included in this report include: a Process Diagramming Tool, a Cost Modeling Tool, an Amortization Modeling Tool, a graphical simulation linked to the Cost Modeling Tool, a decision assistance tool, and a system thinking tool. Additionally, the importance of performance testing to the RTDP and the results of such testing executed is discussed. Further, the results of the Tank Waste Retrieval (TWR) System Diagram, the TWR Operations Cost Model, and the TWR Amortization Model are presented, and the implication of the results are discussed. Finally, the RTDP system analysis tools are assessed and some recommendations are made regarding continuing development of the tools and process.

  14. The engineering of microprocessor systems guidelines on system development

    1979-01-01

    The Engineering of Microprocessor Systems: Guidelines on System Development provides economical and technical guidance for use when incorporating microprocessors in products or production processes and assesses the alternatives that are available. This volume is part of Project 0251 undertaken by The Electrical Research Association, which aims to give managers and development engineers advice and comment on the development process and the hardware and software needed to support the engineering of microprocessor systems. The results of Phase 1 of the five-phase project are contained in this fir

  15. THE DEVELOPMENT OF TROLLEYBUS DRIVE BRAKE SYSTEMS

    A. Safonau

    2011-01-01

    Full Text Available The requirements for trolleybuses brake systems are analyzed. Some results of the studies examined, contemporary trends of developing in this direction are shows. The range of problems whose solution is aimed at creating high-performance brake systems whose increase efficiency and safety of trolleybuses determined.

  16. Work Values System Development during Adolescence

    Porfeli, Erik J.

    2007-01-01

    Work values stability, change, and development can be appreciably reduced to a living system model [Ford, D. H. (1994). "Humans as self-constructing living systems: A developmental perspective on behavior and personality" (2nd ed.). Hillsdale, NJ: Lawrence Erlbaum Associates]. This theoretical model includes discrepancy-reducing and…

  17. Developing a Mobile Distance Learning System

    Rogov, Petr; Borisov, Nikolay

    2007-01-01

    This article considers the basic problems of client-server electronic learning systems based on mobile platforms. Such questions as relational learning course model and student’s transitions prediction through the learning course items are considered. Besides, technical questions of electronic learning system “E-Learning Suite” realization and questions of developing portable applications using .NET Framework are discussed.

  18. Epigenetic Systems View of Human Development.

    Gottlieb, Gilbert

    1991-01-01

    Discusses the history of the hierarchical epigenetic systems view as applied to human development and offers examples of its implementation. Notes the agreement by many authors that the multilevel systems view is the right model for developmental psychology in both human and animal studies. (BC)

  19. Development of the Slovak energy transmission system

    In this presentation author deals with development of the Slovak energy transmission system. Impacts of Bohunice NPP V1 decommissioning as well as impacts of the Mochovce units 3,4 NPP commissioning on transmission system of the Slovak Republic is discussed.

  20. Development of diagnostic system for JT-60 ICRF heating system

    Yokokura, Kenji; Moriyama, Shinichi; Terakado, Masayuki [Japan Atomic Energy Research Inst., Naka, Ibaraki (Japan). Naka Fusion Research Establishment

    1997-09-01

    The ion cyclotron range of frequencies (ICRF) heating system has been operated for eleven years since its completion. Recently, rate of troubles caused by aged deterioration of main components in the heating system is increasing year by year. To keep high availability of the heating system under such conditions and to proceed effective ICRF experiments, a usual checking system to make its performance sure or a rapid trouble shooting when troubles occurred, are required. So we have designed and developed a the diagnostic system which can provide an easy testing of various functions of the ICRF heating system without serious downtime. It was demonstrated that the diagnostic system developed is very useful for the trouble shooting and the various tests and adjustments. (author)

  1. Development of a chemical gas sensor system

    Reichel, Patrick

    2005-01-01

    The main achievement of this work was the development of a chemical gas sensor system for two relevant environmental applications: indoor (carbon monoxide and methane) and outdoor (carbon monoxide and nitrogen dioxide) monitoring of pollutants. Towards this end, three subsequent tasks were accomplished: Firstly, the planning, design and testing of the sensor system supporting the sensing element. Secondly, the laboratory evaluation of the system performance and limitations. Thirdly, the trans...

  2. Redesigning Health Information Systems in Developing Countries

    Mengiste, Shegaw Anagaw; Kimaro, Honest; Aanestad, Margunn

    2008-01-01

    Despite widespread aims to strengthen the Health Information System (HIS) as a tool for decentralised health care, there is a strong tendency in most developing countries that the HIS continues to reflect the central level's needs and requirements. The traditional design approach with little or no...... resources for HIS will be developed at the district and sub-district levels....

  3. ASSESSING RISKS TO THE DEVELOPING IMMUNE SYSTEM

    There is no standardized laboratory animal testing approach to assess the potential toxicity of chemicals to the developing immune system. The goal of this research is to apply a panel of in vivo, ex vivo and in vitro assays to determine whether the developing (i.e., prenatal, n...

  4. The HS6000/20 development system

    In the actual control system of MEA, NIKHEF-K three color displays are in use for graphical representation of the accelerator status information. At the moment the quality of the color displays is bad. The HS6000 development system of the English company Syntel seems to offer a possible solution to replace these displays. In the development system software is developed which finally may run on a target module. The target module, consisting of a processor card with memory and RS232 port and a graphical card, takes care for the control of a color display. The institute has disposed of an experimental set up during two weeks in order to investigate the possibilities and limitations of the development system. The HS6000 development system runs under the OS-9 multi-user and multi-tasking operating system. The operating system takes care for a part of the necessary software to render a computer valuable. The OS-9 operating system disposes of about 60 utility commands. A feature of OS-9 is the application of modular software technique which are based upon memory modules. The interface between the user and the internal functions of the operating system is formed from the shell, the OS-9 command-interpreter code. The software, which has to run on the target module, is written with the help of the Mmacs screen editor, the draw program and the medit editor. The draw program and the medit editor form part of the EGOS ( Enhanced Graphical Output Software) packet. The EGOS packet is a multi-tasking graphical interface for the OS-9 operating system. (author). 1 fig

  5. Spyder: a reconfigurable processor development system

    Iseli, Christian

    1996-01-01

    The Spyder project consists of the development of a reconfigurable processor as well as its application development environment. The name Spyder is an anagram of the first letters of "REconfigurable Processor Development SYstem", where the term reconfigurable means that the hardware of the processor can be specifically tailored for each application. Augmenting the performance of a processor implies either increasing its clock frequency or modifying its architecture. In the latter case, the so...

  6. MODEL DRIVEN DEVELOPMENT OF ONLINE BANKING SYSTEMS

    Bresfelean Vasile Paul

    2011-07-01

    Full Text Available In case of online applications the cycle of software development varies from the routine. The online environment, the variety of users, the treatability of the mass of information created by them, the reusability and the accessibility from different devices are all factors of these systems complexity. The use of model drive approach brings several advantages that ease up the development process. Working prototypes that simplify client relationship and serve as the base of model tests can be easily made from models describing the system. These systems make possible for the banks clients to make their desired actions from anywhere. The user has the possibility of accessing information or making transactions.

  7. Development and Integration of Control System Models

    Kim, Young K.

    1998-01-01

    The computer simulation tool, TREETOPS, has been upgraded and used at NASA/MSFC to model various complicated mechanical systems and to perform their dynamics and control analysis with pointing control systems. A TREETOPS model of Advanced X-ray Astrophysics Facility - Imaging (AXAF-1) dynamics and control system was developed to evaluate the AXAF-I pointing performance for Normal Pointing Mode. An optical model of Shooting Star Experiment (SSE) was also developed and its optical performance analysis was done using the MACOS software.

  8. Development of the simulation monitoring system

    Large-scale simulation technique is studied at the Center for Promotion of Computational Science and Engineering for the computational science research in nuclear fields. Visualization and animation processing techniques are developed for efficient understanding of simulation results. The development of the simulation monitoring system, which is used for real-time visualization of ongoing simulations or for successive visualization of calculated results, is described in this report. The standard visualization tool AVS5 or AVS/EXPRESS is used for the simulation monitoring system, and thus, this system can be utilized in various computer environments. (author)

  9. Instructional systems development model for interactive videodisc

    Campbell, J. O.; Tuttle, D. M.; Gibbons, A. S.

    1983-12-01

    This is the third and final report on an Instructional Systems Development Model for Videodisc Training Delivery Systems with Interactive Capability. The report reviews the current state of the art, and describes two videodiscs made for the project, with lessons learned from them. Each block of the Interservice Procedures for Instructional Systems Development (IPISD) is described in terms of the new opportunities and requirements of interactive videodisc. A separate report, "Interactive Videodisc Design and Production Workshop Guide,' presents a step by step procedure for making interactive videodiscs.

  10. Identification, expression, and biochemical characterization of N-acetylgalactosamine-4-sulfatase mutations and relationship with clinical phenotype in MPS-VI patients

    Litjens, T.; Brooks, D.A.; Hopwood, J.J. [Women`s and Children`s Hospital, North Adelaide (Australia)] [and others

    1996-06-01

    Maroteaux-Lamy syndrome, or mucopolysaccharidosis type VI (MPS-VI), is a lysosomal storage disorder characterized by the defective degradation of dermatan sulfate due to the deficiency of N-acetylgalactosamine-4-sulfatase (4S). The clinical severity of MPS-VI ranges in a continuum from mildly affected to severely affected patients. Mutations in MPS-VI patient samples were identified by chemical cleavage and direct DNA sequencing of PCR products derived from patient cDNA. Five amino acid substitutions were identified (T92M, R95Q, Y210C, H393P, and L498P), individually introduced into the wild-type 4S cDNA by site-directed in vitro mutagenesis, and transfected into Chinese hamster ovary cells. Three of the five mutations (R95Q, Y210C, and H393P) were observed in > 1 of 25 unrelated MPS-VI patients; however, the mutations were not found in 20 control individuals. The residual 4S activity and protein (biochemical phenotype) were determined for each mutant in order to confirm their identity as mutations and to dissect the contribution of each mutant allele to the overall clinical phenotype of the patient. For each patient, the combined biochemical phenotypes of the two 4S mutant alleles demonstrated a good correspondence with the observed clinical phenotype (with the possible exception of a patient who was a compound heterozygote for T92M and L498P). This preliminary correspondence between genotype and the phenotype in MPS-VI may, with further refinement, contribute to the assessment of therapeutic approaches for MPS-VI patients. 30 refs., 4 tabs.

  11. Development of EPICS package for small systems

    EPICS is a control software toolkit, which was developed for large accelerators. The original EPICS assumes to use VME-bus computers and a commercial license of a real-time operating system (VxWorks). However, recent EPICS (version 3.14) can run on many operating system, such as Linux. Thus, EPICS can be introduced at a considerably lower cost than before. We are developing a customized EPICS package, miniEPICS, for small-scale accelerators and experiments. In this paper, we report on the development status of miniEPICS. (author)

  12. Development of cask and transportation system

    The major goal of this project is to establish the safe transport system and obtain the necessary data for cask development by during research work for the design and safety test of shipping cask. The analysis technique using computer code for design has been studied in the field of structure, thermal and shielding analysis in this study. And also the test and measurement technology was developed for the measuring system of drop and fire test. It is expected that research activity ensured in this job will enable us to ultilize the basic data for the cask development. (Author)

  13. development of new dosimetry system using alanine

    The application of nuclear technology in several industrial fields (food, pharmaceutical, biological,), including sterilization of para-pharmaceutical use and conservation of food irradiation, is becoming more widespread during the last decade. Alongside the development of ionization techniques, the development of dosimetry systems for simple routine use is necessary. The aim of this master project is to develop a new dosimetry system for secondary high-performance control radiation doses applied to different matrices, using the spectrophotometric technique as an alternative of the electron paramagnetic resonance spectroscopy (ESR).

  14. Modeling the Development of Organization Management System

    Boris N. Gerasimov

    2015-06-01

    Full Text Available Organization's management system consists of various structural elements. From the position of the functional approach, the structural unit of management activity is functional task management, the realization of which in the course of activities designed control technology. Functioning of many systems management processes and sub-processes is considered. A typical implementation of this act is to solve the set of specific management tasks to achieve the desired goal of a fixed initial situation. The contemporary development of organizations is determined by the necessity to respond to the current challenges and the market trends. In order to react adequately, it is important to use effective means to rebuild the systems of managing the economic systems referred to as organizations. We present a model of organization management system (OMS, and a model of development of organizational processes management system. We review the stages of the said models, including both the conceptual and the technological aspects of organization development based on reengineering. We emphasize the basic advantages of the described models. to reveal the main priorities of economic development of the region and to identify "hot spots", the industries that could be a source of risk and destabilize the economic regional security. Tver region is an example, as its main indicators of economic activity are on the average level of development. It gives the possibility of using tools to support the strategy of economic security at the regional level.

  15. PLM system support for modular product development

    Bruun, Hans Peter Lomholt; Mortensen, Niels Henrik; Harlou, Ulf; Wrsch, Michael

    2015-01-01

    (PDM) and product lifecycle management (PLM) systems offer support by automating and managing some of the operational complexity of modular design activities. PLM system tools are used for handling a variety of product definitions, to manage workflow of development activities, and to measure relational...... properties such as cost and performance. Companies often use a PLM tool for management of CAD files, documents, and drawings, but they do not take advantage of the full potential of the PLM system to support the development activities of modular product designs. The key result of this paper is the...... description of an empirical tested approach using a visual product architecture representation in combination with a PLM system to support the development of a product family of products. The results from the study encompass new PLM capabilities for handling multiple product structures, visualising multiple...

  16. Development of minimally invasive surgery systems

    This review describes the minimally invasive surgery systems developed by the Hitachi group in cooperation with some Japanese universities. Those systems are ''intelliOpe'', a micromanipulator system and ''Naviot''. intelliOpe'', which was developed in cooperation with Tokyo Women's Medical University, is an operation room system with an open MRI equipment by which the image information is available during surgery. The system started from March 2000 and was adopted for 166 brain tumor patients until May 2003. The mean and whole extirpation rates were 91% and 39% respectively, while whole extirpation rate in Japan is 8%. The micromanipulator system for the brain surgery was developed in cooperation with Shinshu University. It consists of 3 micromanipulators and an endoscope, and has been found useful after the first clinical use in August 2002. ''Naviot'' is a laparoscopic manipulator system with a five-bar linkage mechanism recently developed in cooperation with Tokyo University and Kyushu University. ''Naviot'' made it possible for the surgeons to change endoscopic sites easily and safely. As a Hitachi product, ''Naviot'' has been practically used for 51 cases in 16 hospitals until June 2003. (N.I.)

  17. System model development for nuclear thermal propulsion

    A critical enabling technology in the evolutionary development of nuclear thermal propulsion (NTP) is the ability to predict the system performance under a variety of operating conditions. This is crucial for mission analysis and for control subsystem testing as well as for the modeling of various failure modes. Performance must be accurately predicted during steady-state and transient operation, including startup, shutdown, and post operation cooling. The development and application of verified and validated system models has the potential to reduce the design, testing, and cost and time required for the technology to reach flight-ready status. Since Oct. 1991, the U.S. Department of Energy (DOE), Department of Defense (DOD), and NASA have initiated critical technology development efforts for NTP systems to be used on Space Exploration Initiative (SEI) missions to the Moon and Mars. This paper presents the strategy and progress of an interagency NASA/DOE/DOD team for NTP system modeling. It is the intent of the interagency team to develop several levels of computer programs to simulate various NTP systems. The first level will provide rapid, parameterized calculations of overall system performance. Succeeding computer programs will provide analysis of each component in sufficient detail to guide the design teams and experimental efforts. The computer programs will allow simulation of the entire system to allow prediction of the integrated performance. An interagency team was formed for this task to use the best capabilities available and to assure appropriate peer review

  18. Proximity sensor system development. CRADA final report

    Lockheed Martin Energy Research Corporation (LMERC) and Merritt Systems, Inc. (MSI) entered into a Cooperative Research and Development Agreement (CRADA) for the development and demonstration of a compact, modular proximity sensing system suitable for application to a wide class of manipulator systems operated in support of environmental restoration and waste management activities. In teleoperated modes, proximity sensing provides the manipulator operator continuous information regarding the proximity of the manipulator to objects in the workspace. In teleoperated and robotic modes, proximity sensing provides added safety through the implementation of active whole arm collision avoidance capabilities. Oak Ridge National Laboratory (ORNL), managed by LMERC for the United States Department of Energy (DOE), has developed an application specific integrated circuit (ASIC) design for the electronics required to support a modular whole arm proximity sensing system based on the use of capacitive sensors developed at Sandia National Laboratories. The use of ASIC technology greatly reduces the size of the electronics required to support the selected sensor types allowing deployment of many small sensor nodes over a large area of the manipulator surface to provide maximum sensor coverage. The ASIC design also provides a communication interface to support sensor commands from and sensor data transmission to a distributed processing system which allows modular implementation and operation of the sensor system. MSI is a commercial small business specializing in proximity sensing systems based upon infrared and acoustic sensors

  19. Development of an automatic pipeline scanning system

    Kim, Jae H.; Lee, Jae C.; Moon, Soon S.; Eom, Heung S.; Choi, Yu R

    1999-11-01

    Pressure pipe inspection in nuclear power plants is one of the mandatory regulation items. Comparing to manual ultrasonic inspection, automatic inspection has the benefits of more accurate and reliable inspection results and reduction of radiation disposal. final object of this project is to develop an automatic pipeline inspection system of pressure pipe welds in nuclear power plants. We developed a pipeline scanning robot with four magnetic wheels and 2-axis manipulator for controlling ultrasonic transducers, and developed the robot control computer which controls the robot to navigate along inspection path exactly. We expect our system can contribute to reduction of inspection time, performance enhancement, and effective management of inspection results. The system developed by this project can be practically used for inspection works after field tests. (author)

  20. Development of an automatic pipeline scanning system

    Pressure pipe inspection in nuclear power plants is one of the mandatory regulation items. Comparing to manual ultrasonic inspection, automatic inspection has the benefits of more accurate and reliable inspection results and reduction of radiation disposal. final object of this project is to develop an automatic pipeline inspection system of pressure pipe welds in nuclear power plants. We developed a pipeline scanning robot with four magnetic wheels and 2-axis manipulator for controlling ultrasonic transducers, and developed the robot control computer which controls the robot to navigate along inspection path exactly. We expect our system can contribute to reduction of inspection time, performance enhancement, and effective management of inspection results. The system developed by this project can be practically used for inspection works after field tests. (author)

  1. ???????????? Evolutional Development of Library Information Systems

    Hong-Chu Huang

    2010-06-01

    Full Text Available ???????????????????????????????,?????????,???????????????????????????,????????????????????????????????Google??????????????????????????,?????????,?????????????,????4?14??????,?????????????,?????????????????????????????????????????????????????????????????????12?????????????Library information systems are an essential tool for libraries to acquire and organize information resources to deliver services to users. With advancement of information technologies, library information systems have also evolved from card catalogue into diverse ones, such as integrated library system, elec- tronic resource management system, Amazon.com and Google Books. This article aims to review the historical development of library information systems as a basis to explore the future landscape of library information systems. Case study is adopted as research methodology to analyze fourteen library informa- tion systems. Furthermore, research findings and discussions are organized in the following points: type, granularity, boundary, organization and aggrega- tion of object, and representation of information resources, as well as software implementation, social OPAC, software design, operation model, and access.

  2. Is Convection in Developing Tropical Systems Special?

    Kerns, B. W.; Zipser, E. J.; Liu, C.; Greene, K.

    2006-12-01

    This study seeks a difference between non-developing (ND) and developing (D) tropical vorticity maxima, in the Atlantic and East Pacific basins. The vorticity maxima have been tracked manually using time filtered and spatially smoothed ERA-40 Reanalysis, giving a database of 590 ND and 110 D systems for June-October, 1998-2001. Increase in Convective Activity (ICA) events are defined in terms of a relatively large increase in the area of low IR brightness temperature over 12 hours. For June-October, 1998-2001, over 600 ICA events are found with ND systems and over 150 with D systems. In the climatological cyclogenesis regions, there are many ND and many D systems with associated ICA events. This study is motivated by the hypothesis that the nature of the convection may help determine whether a system develops or not. For example, stronger convection may imply stronger vortex stretching on the convective scale, which is then quickly absorbed into the synoptic-scale. Or, more widespread stratiform rain may lead to the production of more and/or stronger mid-level vortices, which may aid development. The position of the convection relative to the vorticity maximum may also play a role. Does the nature and location of the convection matter for cyclogenesis, or is convection playing a passive role with development dependent on the large-scale? Are the current readily-available datasets sufficient to answer this question? In this study, the change in synoptic-scale vorticity in association with ICA events is statistically quantified, for ND and D systems. The vorticity is just as likely to decrease as increase for both types of systems. This may reflect poorly on the quantitative accuracy of the Reanalysis. However, D systems qualitatively tend to both have larger vorticity before the ICA and experience a greater positive change during the ICA. There is a distinct region in the phase space wherein systems are more likely to develop than not develop. We anticipate that looking at other parameters, especially passive microwave-based proxies of convective intensity and coverage, will reveal even more differences between ICA events within developing and non- developing systems.

  3. Expert system development for probabilistic load simulation

    Ho, H.; Newell, J. F.

    1991-05-01

    A knowledge based system LDEXPT using the intelligent data base paradigm was developed for the Composite Load Spectra (CLS) project to simulate the probabilistic loads of a space propulsion system. The knowledge base approach provides a systematic framework of organizing the load information and facilitates the coupling of the numerical processing and symbolic (information) processing. It provides an incremental development environment for building generic probabilistic load models and book keeping the associated load information. A large volume of load data is stored in the data base and can be retrieved and updated by a built-in data base management system. The data base system standardizes the data storage and retrieval procedures. It helps maintain data integrity and avoid data redundancy. The intelligent data base paradigm provides ways to build expert system rules for shallow and deep reasoning and thus provides expert knowledge to help users to obtain the required probabilistic load spectra.

  4. Systems strategies for developing industrial microbial strains

    Lee, Sang Yup; Kim, Hyun Uk

    2015-01-01

    Industrial strain development requires system-wide engineering and optimization of cellular metabolism while considering industrially relevant fermentation and recovery processes. It can be conceptualized as several strategies, which may be implemented in an iterative fashion and in different...... orders. The key challenges have been the time-, cost- and labor-intensive processes of strain development owing to the difficulties in understanding complex interactions among the metabolic, gene regulatory and signaling networks at the cell level, which are collectively represented as overall system...... performance under industrial fermentation conditions. These challenges can be overcome by taking systems approaches through the use of state-of-the-art tools of systems biology, synthetic biology and evolutionary engineering in the context of industrial bioprocess. Major systems metabolic engineering...

  5. Development of a refuelling support system

    In a refuelling operation, it is essential to handle fuel assemblies precisely so as to guarantee quality, and from the standpoint of safety. In order to plan and execute efficient operations, the knowledge of experienced operators is required. Therefore, a support system based on artificial intelligence (AI) technology has been developed, and has been put into operation in actual refuelling operations performed at annual inspection and on scheduled shutdown. This system prepares an optimum refuelling plan, gives the operator step-by-step instructions for operation, and displays and prints out the history of transfer and storage of items. A network uses AI to assist operators with fuel handling facilities and operational rules acquired through operating experience. The system was applied to the real control system in February 1995 and worked successfully. The development of this system has made it possible to optimize the refuelling schedule, reduce the operator's burden and improve the reliability of refuelling

  6. Development of a change management system

    Parks, Cathy Bonifas

    1993-01-01

    The complexity and interdependence of software on a computer system can create a situation where a solution to one problem causes failures in dependent software. In the computer industry, software problems arise and are often solved with 'quick and dirty' solutions. But in implementing these solutions, documentation about the solution or user notification of changes is often overlooked, and new problems are frequently introduced because of insufficient review or testing. These problems increase when numerous heterogeneous systems are involved. Because of this situation, a change management system plays an integral part in the maintenance of any multisystem computing environment. At the NASA Ames Advanced Computational Facility (ACF), the Online Change Management System (OCMS) was designed and developed to manage the changes being applied to its multivendor computing environment. This paper documents the research, design, and modifications that went into the development of this change management system (CMS).

  7. Hydrogen storage and delivery system development

    Handrock, J.L.; Wally, K.; Raber, T.N. [Sandia National Labs., Livermore, CA (United States)

    1995-09-01

    Hydrogen storage and delivery is an important element in effective hydrogen utilization for energy applications and is an important part of the FY1994-1998 Hydrogen Program Implementation Plan. The purpose of this project is to develop a platform for the engineering evaluation of hydrogen storage and delivery systems with an added focus on lightweight hydride utilization. Hybrid vehicles represent the primary application area of interest, with secondary interests including such items as existing vehicles and stationary uses. The near term goal is the demonstration of an internal combustion engine/storage/delivery subsystem. The long term goal is optimization of storage technologies for both vehicular and industrial stationary uses. In this project an integrated approach is being used to couple system operating characteristics to hardware development. A model has been developed which integrates engine and storage material characteristics into the design of hydride storage and delivery systems. By specifying engine operating parameters, as well as a variety of storage/delivery design features, hydride bed sizing calculations are completed. The model allows engineering trade-off studies to be completed on various hydride material/delivery system configurations. A more generalized model is also being developed to allow the performance characteristics of various hydrogen storage and delivery systems to be compared (liquid, activated carbon, etc.). Many of the features of the hydride storage model are applicable to the development of this more generalized model.

  8. Development of Solar Powered Irrigation System

    Development of a solar powered irrigation system has been discussed in this paper. This system would be SCADA-based and quite useful in areas where there is plenty of sunshine but insufficient water to carry out farming activities, such as rubber plantation, strawberry plantation, or any plantation, that requires frequent watering. The system is powered by solar system as a renewable energy which uses solar panel module to convert Sunlight into electricity. The development and implementation of an automated SCADA controlled system that uses PLC as a controller is significant to agricultural, oil and gas monitoring and control purpose purposes. In addition, the system is powered by an intelligent solar system in which solar panel targets the radiation from the Sun. Other than that, the solar system has reduced energy cost as well as pollution. The system is equipped with four input sensors; two soil moisture sensors, two level detection sensors. Soil moisture sensor measures the humidity of the soil, whereas the level detection sensors detect the level of water in the tank. The output sides consist of two solenoid valves, which are controlled respectively by two moistures sensors

  9. Development of Solar Powered Irrigation System

    Abdelkerim, A. I.; Sami Eusuf, M. M. R.; Salami, M. J. E.; Aibinu, A.; Eusuf, M. A.

    2013-12-01

    Development of a solar powered irrigation system has been discussed in this paper. This system would be SCADA-based and quite useful in areas where there is plenty of sunshine but insufficient water to carry out farming activities, such as rubber plantation, strawberry plantation, or any plantation, that requires frequent watering. The system is powered by solar system as a renewable energy which uses solar panel module to convert Sunlight into electricity. The development and implementation of an automated SCADA controlled system that uses PLC as a controller is significant to agricultural, oil and gas monitoring and control purpose purposes. In addition, the system is powered by an intelligent solar system in which solar panel targets the radiation from the Sun. Other than that, the solar system has reduced energy cost as well as pollution. The system is equipped with four input sensors; two soil moisture sensors, two level detection sensors. Soil moisture sensor measures the humidity of the soil, whereas the level detection sensors detect the level of water in the tank. The output sides consist of two solenoid valves, which are controlled respectively by two moistures sensors.

  10. Statement about researches relative to the operation stability of the MPS P230 of Ariane 5; Point sur les recherches relatives a la stabilite de fonctionnement du MPS P230 d'Ariane 5

    Vuillot, F.

    1998-07-01

    This paper makes a statement about the researches carried out in the framework of the ASSM (Aerodynamics of Segmented Solid Motors) research program on the operation stability of the MPS P230 solid propellant engine of the French Ariane 5 launcher. After a brief historical recall of the works performed on this topic during the last 10 years, the present day situation is detailed. The feasibility of a numerical capture of the instability phenomenon is now achieved and 3 scenarios leading to swirl flow instabilities could be identified. These scenarios were validated using numerical simulation, simulation in cold gases, and launcher tests. However, one scenario based on a strong instability mechanism, seems to better fit with the observations made on the P230 engine and will deeply influence the scientific strategy of the research program. (J.S.)

  11. Cryogenic Propellant Feed System Analytical Tool Development

    Lusby, Brian S.; Miranda, Bruno M.; Collins, Jacob A.

    2011-01-01

    The Propulsion Systems Branch at NASA s Lyndon B. Johnson Space Center (JSC) has developed a parametric analytical tool to address the need to rapidly predict heat leak into propellant distribution lines based on insulation type, installation technique, line supports, penetrations, and instrumentation. The Propellant Feed System Analytical Tool (PFSAT) will also determine the optimum orifice diameter for an optional thermodynamic vent system (TVS) to counteract heat leak into the feed line and ensure temperature constraints at the end of the feed line are met. PFSAT was developed primarily using Fortran 90 code because of its number crunching power and the capability to directly access real fluid property subroutines in the Reference Fluid Thermodynamic and Transport Properties (REFPROP) Database developed by NIST. A Microsoft Excel front end user interface was implemented to provide convenient portability of PFSAT among a wide variety of potential users and its ability to utilize a user-friendly graphical user interface (GUI) developed in Visual Basic for Applications (VBA). The focus of PFSAT is on-orbit reaction control systems and orbital maneuvering systems, but it may be used to predict heat leak into ground-based transfer lines as well. PFSAT is expected to be used for rapid initial design of cryogenic propellant distribution lines and thermodynamic vent systems. Once validated, PFSAT will support concept trades for a variety of cryogenic fluid transfer systems on spacecraft, including planetary landers, transfer vehicles, and propellant depots, as well as surface-based transfer systems. The details of the development of PFSAT, its user interface, and the program structure will be presented.

  12. PSSD - Planning System for Sustainable Development

    PSSD - Planning System for Sustainable Development - is a part of the Baltic Sea Region's INTERREG II C program. The current report describes some theories, methods and tools developed under the PSSD project. First, the theoretical foundation of the project is described. Secondly, the role of...... indicators in sustainable development is discussed and a Web-based indicator generator is described. Thirdly, we describe a number of methods and tools, which support planning for sustainable development. Finally, some technical interface tools - especially a Web-based interface to the methods and tools, the...

  13. Development of automated blender and dispensing system

    This paper describes automated blender and dispensing system designed and developed in Nuclear Recycle Board for its reprocessing plant. Obtaining sinterable grade oxide powder from the product solution received in the heavy metal product line involves skilled manpower and time consuming, laborious manual operations. Entire treatment is carried out in a train of closed containments called as glove boxes. In view of this Automated blender and dispensing system has been developed to reduce tedious manual operations. System consists of PLC based control system to drive motorised charging mechanism, a conical ribbon blender which homogenises the product and load cell triggered, indexing dispensing mechanism. Schematic design of the system has been done in-house, while fabrication was outsourced. System has been built, tested and installed at component test facility (CTF) at Tarapur. Actual blending tests were carried out by using dummy material like calcium carbonate and barium carbonate powder, with different sets of parameter. Blended product was chemically analysed for its homogeneity. System has now been put to trial runs by operating staff. This development has circumvented tedious operations of Scooping and increased the throughput. This paper describes challenges in undertaking this developmental work. (author)

  14. Development of the Hypothalamic Melanocortin System

    SebastienGBouret

    2013-03-01

    Full Text Available The melanocortin system is a critical component of the forebrain and hindbrain regulatory systems involved in energy balance. This system is composed of pro-opiomelanocortin (POMC neurons that act, in part, through the melanocortin-4 receptor (MC4R. Although the importance of the melanocortin system in controlling feeding has been established for two decades, the understanding of the developmental substrates underlying POMC and MC4R neuron development and function has just begun to emerge. The formation of the melanocortin system involves several discrete developmental steps that include the birth and fate specification of POMC- and MC4R-containing neurons and the extension and guidance of POMC axons to their MC4R-expressing target nuclei. Each of these developmental processes appears to require specific sets of genes and developmental cues that include perinatal hormones. Recent evidence has also highlighted the importance of perinatal nutrition in controlling the ultimate architecture of the melanocortin system.

  15. Progress of the TPS control system development

    The Taiwan Photon Source (TPS) is a low-emittance 3-GeV synchrotron light source that is being built at the National Synchrotron Radiation Research Center (NSRRC) campus. Control system for the TPS is based on EPICS (Experimental Physics and Industrial Control System) framework. Standard hardware and software components have been defined. Prototypes of various subsystems are in implementation. Event based timing system has been adopted. Power supply control interface accompany with orbit feedback support are also defined. Machine protection system is in design phase. Integration with the linear accelerator system which are installed and commissioned at the temporary site for acceptance test has been already done. Interface to various system are still in negotiate stage. Development of the infrastructure of high level and low level software are on going. Progress will be summarized in the report. (authors)

  16. Development of compact CCTV surveillance system 'COSMOS'

    The Compact Surveillance Monitoring System (COSMOS) has been developed as a compact, simple, highly reliable CCTV surveillance system. The system is intended to provide a replacement for the IAEA Twin Minolta Film Camera System. The system consists of a recording unit and a set up/review unit. The recording unit consisting of a CCD camera module, a 8 mm VTR unit, a controller module and a power unit is enclosed in a tamper-indicating housing. The VTR module of very low power consumption is specially designed for COSMOS capable of battery operation. The system can be operated for three months either by battery where mains power is not readily available or by AC powers. The prototype of COSMOS was completed in 1989 and the field-evaluation model will be tested for acceptance at the IAEA from August 1990. (author)

  17. Development of integrated CAD system PV-1

    An integrated CAD system for pressure vessels, such as heat exchangers, drums, towers, jacketed vessels, and tanks, has been developed. The system is operated by MS-DOS personal computers combined in a LAN. Pressure vessel designers can work watching using the computer display because the system automatically manages design work, on a common data base. The project team members in other sections, such as production, cost control, and design, have the same data concurrently. Personal computers unite the 3D CAD system, and the generated design with detail dimensions and shapes is stored in the 3D CAD system automatically. The system has promoted higher design quality and greatly reduced design cost. (author)

  18. Groundwork for Universal Canister System Development

    Price, Laura L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Gross, Mike [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Prouty, Jeralyn L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Rigali, Mark J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Craig, Brian [Argonne National Lab. (ANL), Argonne, IL (United States); Han, Zenghu [Argonne National Lab. (ANL), Argonne, IL (United States); Lee, John Hok [Argonne National Lab. (ANL), Argonne, IL (United States); Liu, Yung [Argonne National Lab. (ANL), Argonne, IL (United States); Pope, Ron [Argonne National Lab. (ANL), Argonne, IL (United States); Connolly, Kevin [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Feldman, Matt [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Jarrell, Josh [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Radulescu, Georgeta [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Scaglione, John [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Wells, Alan [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-09-01

    The mission of the United States Department of Energy's Office of Environmental Management is to complete the safe cleanup of the environmental legacy brought about from five decades of nuclear weapons development and go vernment - sponsored nuclear energy re search. S ome of the waste s that that must be managed have be en identified as good candidates for disposal in a deep borehole in crystalline rock (SNL 2014 a). In particular, wastes that can be disposed of in a small package are good candidates for this disposal concept. A canister - based system that can be used for handling these wastes during the disposition process (i.e., storage, transfers, transportation, and disposal) could facilitate the eventual disposal of these wastes. This report provides information for a program plan for developing specifications regarding a canister - based system that facilitates small waste form packaging and disposal and that is integrated with the overall efforts of the DOE's Office of Nuclear Energy Used Fuel Dis position Camp aign's Deep Borehole Field Test . Groundwork for Universal Ca nister System Development September 2015 ii W astes to be considered as candidates for the universal canister system include capsules containing cesium and strontium currently stored in pools at the Hanford Site, cesium to be processed using elutable or nonelutable resins at the Hanford Site, and calcine waste from Idaho National Laboratory. The initial emphasis will be on disposal of the cesium and strontium capsules in a deep borehole that has been drilled into crystalline rock. Specifications for a universal canister system are derived from operational, performance, and regulatory requirements for storage, transfers, transportation, and disposal of radioactive waste. Agreements between the Department of Energy and the States of Washington and Idaho, as well as the Deep Borehole Field Test plan provide schedule requirements for development of the universal canister system . Future work includes collaboration with the Hanford Site to move the cesium and strontium capsules into dry storage, collaboration with the Deep Borehole Field Tes t to develop surface handling and emplacement techniques and to develop the waste package design requirements, developing universal canister system design options and concepts of operations, and developing system analysis tools. Areas in which f urther research and development are needed include material properties and structural integrity, in - package sorbents and fillers, waste form tolerance to heat and postweld stress relief, waste package impact limiters, sensors, cesium mobility under downhol e conditions, and the impact of high pressure and high temperature environment on seals design.

  19. A Systems Engineering Approach to Architecture Development

    Di Pietro, David A.

    2015-01-01

    Architecture development is often conducted prior to system concept design when there is a need to determine the best-value mix of systems that works collectively in specific scenarios and time frames to accomplish a set of mission area objectives. While multiple architecture frameworks exist, they often require use of unique taxonomies and data structures. In contrast, this paper characterizes architecture development using terminology widely understood within the systems engineering community. Using a notional civil space architecture example, it employs a multi-tier framework to describe the enterprise level architecture and illustrates how results of lower tier, mission area architectures integrate into the enterprise architecture. It also presents practices for conducting effective mission area architecture studies, including establishing the trade space, developing functions and metrics, evaluating the ability of potential design solutions to meet the required functions, and expediting study execution through the use of iterative design cycles

  20. Development of Constellation's Launch Control System

    Lougheed, Kirk D.; Peaden, Cary J.

    2010-01-01

    The paper focuses on the National Aeronautics and Space Administration (NASA) Constellation Program's Launch Control System (LCS) development effort at Kennedy Space Center (KSC). It provides a brief history of some preceding efforts to provide launch control and ground processing systems for other NASA programs, and some lessons learned from those experiences. It then provides high level descriptions of the LCS mission, objectives, organization, architecture, and progress. It discusses some of our development tenets, including our use of standards based design and use of off-the-shelf products whenever possible, incremental development cycles, and highly reliable, available, and supportable enterprise class system servers. It concludes with some new lessons learned and our plans for the future.

  1. Development of the data acquisition system 'MORAINE'

    This publication presents the software development of the data acquisition system 'MORAINE'. The distributed multiprocessor system is designed for the spectrometer SPHERE. The system consists of three VME processor modules, specialized FASTBUS modules, three personal computers (IBM PC) type networked with local Ethernet. The software is developed for three VME processor modules. It controls the reading of event fragments into VME processor modules and uses data block transfer via direct memory access, reconstructs the events, transfers data into the local network for on-line analysis and records data on external media for OFF-line analysis. The usage of the distributed computer system allows one to duplicate the efficiency of the spectrometer due to parallel reading event fragments. (author)

  2. Software development methodology for high consequence systems

    Baca, L.S.; Bouchard, J.F.; Collins, E.W.; Eisenhour, M.; Neidigk, D.D.; Shortencarier, M.J.; Trellue, P.A.

    1997-10-01

    This document describes a Software Development Methodology for High Consequence Systems. A High Consequence System is a system whose failure could lead to serious injury, loss of life, destruction of valuable resources, unauthorized use, damaged reputation or loss of credibility or compromise of protected information. This methodology can be scaled for use in projects of any size and complexity and does not prescribe any specific software engineering technology. Tasks are described that ensure software is developed in a controlled environment. The effort needed to complete the tasks will vary according to the size, complexity, and risks of the project. The emphasis of this methodology is on obtaining the desired attributes for each individual High Consequence System.

  3. Developing Automatic Controllers for sprinkler irrigation systems

    Playn, E.; Salvador, R.; Cavero, J.; Lpez, C.; Lecina, S.; Zapata, N.

    2012-04-01

    The application of new technologies to the control and automation of irrigation processes is quickly gaining attention. The automation of irrigation execution (through irrigation controllers) is now widespread. However, the automatic generation and execution of irrigation schedules is receiving growing attention due to the possibilities offered by the telemetry/remote control systems currently being installed in collective pressurized networks. These developments can greatly benefit from the combination of irrigation system and crop models, and from the interaction with agrometeorological databases, hydraulic models of pressurized collective distribution networks, weather forecasts and management databases for water users associations. Prospects for the development of such systems in collective sprinkler irrigation systems are analyzed in this presentation. Additionally, experimental results are presented on the application of these concepts to a hydrant irrigating a solid-set irrigated maize field.

  4. Space Station battery system design and development

    Haas, R. J.; Chawathe, A. K.; Van Ommering, G.

    1988-01-01

    The Space Station Electric Power System will rely on nickel-hydrogen batteries in its photovoltaic power subsystem for energy storage to support eclipse and contingency operations. These 81-Ah batteries will be designed for a 5-year life capability and are configured as orbital replaceable units (ORUs), permitting replacement of worn-out batteries over the anticipated 30-year Station life. This paper describes the baseline design and the development plans for the battery assemblies, the battery ORUs and the battery system. Key elements reviewed are the cells, mechanical and thermal design of the assembly, the ORU approach and interfaces, and the electrical design of the battery system. The anticipated operational approach is discussed, covering expected performance as well as the processor-controlled charge management and discharge load allocation techniques. Development plans cover verification of materials, cells, assemblies and ORUs, as well as system-level test and analyses.

  5. Reactor alarm system development and application issues

    The new hardware and software technologies, and the need in research reactors for assistance systems in operation and maintenance, have given an appropriate background to develop a computer based system named ''Reactor Alarm System'' (RAS). RAS is a software package, user oriented, with emphasis on production, experiments and maintenance goals. It is designed to run on distributed systems conformed with microcomputers under QNX operating system. RAS main features are: a) Alarm Panel Display; b) Alarm Page; c) Alarm Masking and Inhibition; d) Alarms Color and Attributes; e) Condition Classification; and f) Arrangement Presentation. RAS design allows it to be installed as a part of a computer based Supervision and Control System in new installations or retrofit existing reactor instrumentation systems. The analysis of human factors during development stage and successive user feedback from different applications, brought out several RAS improvements: a) Multiple-copy alarm summaries; b) Improved alarm handling; c) Extended dictionary; and d) Enhanced hardware availability. It has proved successful in providing new capabilities for operators, and also has shown the continuous increase of user-demands, reflecting the expectations placed today on computer-based systems. (author). 6 figs, 1 tabs

  6. Characteristics of energy systems development. - Systems for management of energy development in the USSR

    Makarova, A.S.; Smirnov, V.A.; Eskin, V.I.; Makarov, A.A. (Academy of Sciences, Moscow (USSR). Energy Research Inst. State Committee for Science and Technology, Moscow (USSR)); Tkachenko, G.E.; Shevchuk, L.M. (Academy of Sciences, Irkutsk (USSR). Siberian Energy Inst.)

    1991-12-01

    The first paper generalizes the results obtained from studies of the characteristics of energy systems development and associated principles of management and simulation. Particular attention is given to the management of system development when there is uncertainty. System dynamics, flexibility, adaptability and reliability are some of the properties studied. It is shown why guaranteed strategies are preferable for securing maximum reliability of energy systems development and most efficient distribution among energy industries of the limited resources of the national economy. In the second paper the system for centralized management of energy development in the USSR and planned methods of improvement by increasing the economic independence of power plants and making economic control links more effective are analyzed. The degree and organization of control over energy development are considered as an organized hierarchical process. The system of work (make-up, sequence and content) for controlling energy development currently in existence in the USSR is discussed. (orig.).

  7. Hydrogen storage and delivery system development: Analysis

    Handrock, J.L. [Sandia National Labs., Livermore, CA (United States)

    1996-10-01

    Hydrogen storage and delivery is an important element in effective hydrogen utilization for energy applications and is an important part of the FY1994-1998 Hydrogen Program Implementation Plan. This project is part of the Field Work Proposal entitled Hydrogen Utilization in Internal Combustion Engines (ICE). The goal of the Hydrogen Storage and Delivery System Development Project is to expand the state-of-the-art of hydrogen storage and delivery system design and development. At the foundation of this activity is the development of both analytical and experimental evaluation platforms. These tools provide the basis for an integrated approach for coupling hydrogen storage and delivery technology to the operating characteristics of potential hydrogen energy use applications. Results of the analytical model development portion of this project will be discussed. Analytical models have been developed for internal combustion engine (ICE) hybrid and fuel cell driven vehicles. The dependence of hydride storage system weight and energy use efficiency on engine brake efficiency and exhaust temperature for ICE hybrid vehicle applications is examined. Results show that while storage system weight decreases with increasing engine brake efficiency energy use efficiency remains relatively unchanged. The development, capability, and use of a recently developed fuel cell vehicle storage system model will also be discussed. As an example of model use, power distribution and control for a simulated driving cycle is presented. Model calibration results of fuel cell fluid inlet and exit temperatures at various fuel cell idle speeds, assumed fuel cell heat capacities, and ambient temperatures are presented. The model predicts general increases in temperature with fuel cell power and differences between inlet and exit temperatures, but under predicts absolute temperature values, especially at higher power levels.

  8. PLM system support for modular product development

    Bruun, Hans Peter Lomholt; Mortensen, Niels Henrik; Harlou, Ulf; Wörösch, Michael

    2015-01-01

    (PDM) and product lifecycle management (PLM) systems offer support by automating and managing some of the operational complexity of modular design activities. PLM system tools are used for handling a variety of product definitions, to manage workflow of development activities, and to measure relational...... architectural views on products, controlling interfaces, and quantifying and communicating the status and progress of product-related resources. © 2014 Elsevier B.V. All rights reserved....

  9. A Guerilla Approach to Control System Development

    Dovc, J.; Milcinski, G.; Plesko, M.

    2001-01-01

    We present our experiences in managing the development cycles of the control systems for ANKA and the ALMA Common Software. Our team consists practically only of undergraduate students. Stimulating and rewarding the students with cutting-edge technologies and travel to conferences like this and installation fieldwork are an important positive factor in raising their motivation. However, building any system with a group of inexperienced students is quite a challenging task. Many problems occur...

  10. Intrinsic Motivation Systems for Autonomous Mental Development

    Oudeyer, Pierre-Yves; Kaplan, Frederic; Hafner, Verena

    2007-01-01

    Exploratory activities seem to be intrinsically rewarding for children and crucial for their cognitive development. Can a machine be endowed with such an intrinsic motivation system? This is the question we study in this paper, presenting a number of computational systems that try to capture this drive towards novel or curious situations. After discussing related research coming from developmental psychology, neuroscience, developmental robotics, and active learning, this paper prese...

  11. Developing an Information Security Management System

    Karjalainen, Mika

    2014-01-01

    The purpose of this thesis was to study development of an information security management system and study the resources and components, which combined create a functional information security management system. To reach the target objective, the thesis first examines the international and international legislation regarding information security. Secondly, the information security related international and national standards and frameworks are analyzed and compared. Finally the outcome of the...

  12. Remote viewing system development in BNFL

    The application of imaging systems to BNFL's plants is primarily provided by the Company's Engineering Group. Many systems have been developed for active service and several new developments are currently in an advanced stage of implementation. BNFL has acquired extensive experience of remote viewing from a series of projects undertaken for the Sellafield site in West Cumbria. Applications vary in size and complexity, from simple identification of bar-codes to more complex schemes for remotely storing UO3 drums. Some are high speed and highly repetitive, whereas others are low speed but require high precision. In this paper the authors shall outline a selection of current applications. (Author)

  13. Remote viewing system development in BNFL

    The application of imaging systems to BNFL's plants is primarily provided by the Company's Engineering Group. Many systems have been developed for active service and several new developments are currently in an advanced stage of implementation. BNFL has acquired extensive experience of remote viewing from a series of projects undertaken for the Sellafield site in West Cumbria. Applications vary in size and complexity, from simple identification of bar-codes to more complex schemes for remotely storing UO3 drums. Some are high speed and highly repetitive, whereas others are low speed but require high precision. In this paper the authors outline a selection of current applications. (UK)

  14. System development and asset management under restructuring

    In many developed countries the electricity infrastructure contains ageing assets. Because of the need of a continuing operation and higher load factors on the network, the opportunities for replacement or refurbishment are limited. These must be regarded as an opportunity to review the structure of the system and to consider the design and development required to meet the new requirements, taking advantage of new available technologies: HVDC, FACTS, cables, etc. The symposium examines assets management issues and assesses strategies for overhauling existing systems, taking into account the impact on market operation, on supply security and environment

  15. Development of an integrated radiotherapy network system

    Purpose: To introduce the process of developing an integrated radiotherapy network. Methods and Materials: We developed a new radiotherapy treatment-planning system in 1987 that we named the Computed Tomography (CT) simulator. CT images were immediately transported to multiimage monitors and to a planning computer, and treatment planning could be performed with the patient lying on the CT couch. The results of planning were used to guide a laser projector, and radiation fields were projected onto the skin of the patient. Since 1991, an integrated radiotherapy network system has been developed, which consists of a picture archiving and communicating system (PACS), a radiotherapy information database, a CT simulator, and a linear accelerator with a multileaf collimator. Results: Clinical experience has been accumulated in more than 1,100 patients. Based on our 7 years of experience, we have modified several components of our original CT simulator and have developed a second generation CT simulator. A standard protocol has been developed for communication between the CT scanner, treatment planning computer, and radiotherapy apparatus using the Ethernet network. As a result, treatment planning data can be transported to the linear accelerator within 1 min after completion of treatment planning. Conclusion: This system enables us to make optimal use of CT information and to devise accurate three-dimensional (3D) treatment-planning programs. Our network also allows for the performance of fully computer-controlled dynamic arc conformal therapy

  16. Development of an automatic reactor inspection system

    Using recent technologies on a mobile robot computer science, we developed an automatic inspection system for weld lines of the reactor vessel. The ultrasonic inspection of the reactor pressure vessel is currently performed by commercialized robot manipulators. Since, however, the conventional fixed type robot manipulator is very huge, heavy and expensive, it needs long inspection time and is hard to handle and maintain. In order to resolve these problems, we developed a new automatic inspection system using a small mobile robot crawling on the vertical wall of the reactor vessel. According to our conceptual design, we developed the reactor inspection system including an underwater inspection robot, a laser position control subsystem, an ultrasonic data acquisition/analysis subsystem and a main control subsystem. We successfully carried out underwater experiments on the reactor vessel mockup, and real reactor ready for Ulchine nuclear power plant unit 6 at Dusan Heavy Industry in Korea. After this project, we have a plan to commercialize our inspection system. Using this system, we can expect much reduction of the inspection time, performance enhancement, automatic management of inspection history, etc. In the economic point of view, we can also expect import substitution more than 4 million dollars. The established essential technologies for intelligent control and automation are expected to be synthetically applied to the automation of similar systems in nuclear power plants

  17. Asian Financial System: Development and Challenges

    Park, Cyn-Young

    2011-01-01

    Postcrisis policy responses tilted in favor of strengthening the global regulatory system and financial stability have limited the attention paid to the role of finance in supporting sustained economic growth and development. This has special implications for Asia which, despite being the new engine of growth to the world economy, continues to be challenged by the persistent gap between developments in its financial and real sectors. This paper examines how Asia's financial and economic lands...

  18. Some problems in large superconducting system development

    The experience in developments of large superconducting magnetic systems (SMS) for investigations into controlled fusion, accumulated in the Kurchatov Institute of Atomic Energy, is analyzed. The early operating SMS of the immersion and circulation type are described. The specifications of SMS being developed are presented. The advantages of circulation-type devices over the immersion-type ones are demostrated. The prospects for use of SMS on multistrand intermetallic materials are briefly outlined

  19. Development of KSTAR Neutral Beam Heating System

    Oh, B. H.; Song, W. S.; Yoon, B. J. (and others)

    2007-10-15

    The prototype components of a neutral beam injection (NBI) system have been developed for the KSTAR, and a capability of the manufactured components has been tested. High power ion source, acceleration power supply, other ion source power supplies, neutralizer, bending magnet for ion beam separation, calorimeter, and cryo-sorption pump have been developed by using the domestic technologies and tested for a neutral beam injection of 8 MW per beamline with a pulse duration of 300 seconds. The developed components have been continuously upgraded to achieve the design requirements. The development technology of high power and long pulse neutral beam injection system has been proved with the achievement of 5.2 MW output for a short pulse length and 1.6 MW output for a pulse length of 300 seconds. Using these development technologies, the domestic NB technology has been stabilized under the development of high power ion source, NB beamline components, high voltage and current power supplies, NB diagnostics, NB system operation and control.

  20. Development of KSTAR Neutral Beam Heating System

    The prototype components of a neutral beam injection (NBI) system have been developed for the KSTAR, and a capability of the manufactured components has been tested. High power ion source, acceleration power supply, other ion source power supplies, neutralizer, bending magnet for ion beam separation, calorimeter, and cryo-sorption pump have been developed by using the domestic technologies and tested for a neutral beam injection of 8 MW per beamline with a pulse duration of 300 seconds. The developed components have been continuously upgraded to achieve the design requirements. The development technology of high power and long pulse neutral beam injection system has been proved with the achievement of 5.2 MW output for a short pulse length and 1.6 MW output for a pulse length of 300 seconds. Using these development technologies, the domestic NB technology has been stabilized under the development of high power ion source, NB beamline components, high voltage and current power supplies, NB diagnostics, NB system operation and control

  1. Development of intelligent supervisory control system

    The objective of the development of an intelligent supervisory control system for next generation plants is enhancement of the operational reliability by applying the recent outcome of artificial intelligence and computer technologies. This system consists of the supervisory control and monitoring for automatic operation, the equipment operation support for historical data management and for test scheduling, the operators' decision making support for accidental plant situations and the human-friendly interface of these support functions. The verification test results showed the validity of the functions realized by this system for the next generation control room. (author)

  2. Development of subpicosecond pulse radiolysis system

    Kozawa, T; Miki, M; Yamamoto, T; Suemine, S; Yoshida, Y; Tagawa, S

    2000-01-01

    The highest time resolution of the pulse radiolysis had remained about 30 ps since the late 1960s. To make clear the primary processes in the radiation chemistry and physics within 30 ps, we developed a stroboscopic pulse radiolysis system for the absorption spectroscopy with the time resolution of 2.0 ps (10-90% rise time). The time resolution of 2.0 ps was estimated from the time-dependent behavior of the hydrated electrons. The system consists of a subpicosecond electron linac as an irradiation source, a femtosecond laser as an analyzing light and a jitter compensation system.

  3. Development of flaw imaging system with EMAT

    The authors present a flaw imaging system for a pipe developed by using an electromagnetic acoustic transducer (EMAT). This system uses two small-sized 2 MHz SH wave EMATs as its ultrasonic probes. For signal processing, it employs a signal averaging method to reduce noise, and a synthetic aperture focusing method to obtain flaw cross-sectional images. The system was tested by probing artificial flaws on the internal surface of an austenitic stainless steel pipe. This test shows that cross-sectional image, C scopes and three-dimensional displays of flaws are possible

  4. Developing stereo image based robot control system

    Application of image processing is developed in various field and purposes. In the last decade, image based system increase rapidly with the increasing of hardware and microprocessor performance. Many fields of science and technology were used this methods especially in medicine and instrumentation. New technique on stereovision to give a 3-dimension image or movie is very interesting, but not many applications in control system. Stereo image has pixel disparity information that is not existed in single image. In this research, we proposed a new method in wheel robot control system using stereovision. The result shows robot automatically moves based on stereovision captures

  5. Developing stereo image based robot control system

    Suprijadi,; Pambudi, I. R.; Woran, M.; Naa, C. F; Srigutomo, W. [Department of Physics, FMIPA, InstitutTeknologi Bandung Jl. Ganesha No. 10. Bandung 40132, Indonesia supri@fi.itb.ac.id (Indonesia)

    2015-04-16

    Application of image processing is developed in various field and purposes. In the last decade, image based system increase rapidly with the increasing of hardware and microprocessor performance. Many fields of science and technology were used this methods especially in medicine and instrumentation. New technique on stereovision to give a 3-dimension image or movie is very interesting, but not many applications in control system. Stereo image has pixel disparity information that is not existed in single image. In this research, we proposed a new method in wheel robot control system using stereovision. The result shows robot automatically moves based on stereovision captures.

  6. Development and implementation of integrated management system

    Risk Engineering Ltd is a private Bulgarian company in the field of scientific technical consultancy and engineering services, established in 1990. The aim of this report is to present the experience of Risk Engineering Ltd. in the development, implementation and operation of an integrated management system. The process of implementation of the system was completed at the end of 2011. In January 2012, the Risk Engineering Integrated Management System was certified by Lloyd's Register for compliance with standards ISO 9001:2008, ISO 140001:2004 and BS OHSAS 18001:2007

  7. Development of nuclear safety information retrieval system

    An on-line information retrieval system for quickly analyzing safety-related informations in nuclear power plants has been developed. By analyzing and evaluating the operating experience/failure reports it is shown that the system is a convenient tool in considering to have the availability of nuclear plants increased. The system may also be used for a variety of purposes. For example, it is useful as a data base for evaluation of the component reliability or for taking measures to meet the various failure situation of the nuclear plants. (author)

  8. Developing stereo image based robot control system

    Suprijadi, Pambudi, I. R.; Woran, M.; Naa, C. F.; Srigutomo, W.

    2015-04-01

    Application of image processing is developed in various field and purposes. In the last decade, image based system increase rapidly with the increasing of hardware and microprocessor performance. Many fields of science and technology were used this methods especially in medicine and instrumentation. New technique on stereovision to give a 3-dimension image or movie is very interesting, but not many applications in control system. Stereo image has pixel disparity information that is not existed in single image. In this research, we proposed a new method in wheel robot control system using stereovision. The result shows robot automatically moves based on stereovision captures.

  9. Development of a thermoluminescent personnel monitoring system

    Thermoluminescent personnel monitoring system has been developed by the Division of Radiological Protection, Bhabha Atomic Research Centre (BARC), Bombay. The system is presently in use for estimation of personnel doses of radiation workers of BARC, other units of the Department of Atomic Energy, and Defence medical units in India. The report gives salient features of the TLD personnel monitoring system. The report discusses design considerations of thermoluminescent dosimetry (TLD) badge for measurement of X and ?;, ? personnel exposures, a filter combination to compensate for energy dependence of the TLD disc and angular dependence of the badge. The badge reader incorporates a semiautomatic mechanical arrangement wherein the TLD cards are read, raising the heater after positioning the TLD discs one by one. Various figures illustrate the mechanical layouts and electronics circuits used in the system. Periodic quality assurance check of the system which ensures a good reproducibility, is also described. (author)

  10. Recent developments in man-machine systems

    The field of man-machine systems is introduced with its subareas and a short outline of its history of 45 years. Three current lines of development in university and industrial research are emphasized. Today, the human problem solving activities are experimentally investigated and analytically described more vigorously than the control activities. Further, improved information presentations and decision support are made possible through new technologies of computer graphics and expert systems. At last, work on a general design methodology for man-machine systems is in progress. The aim is to better support human operators of dynamic technological systems as well as designers of graphics for visual display units and of dialogue styles. Thereby, safety and availability of the complete system can be increased. (orig.)

  11. Oral health care systems in developing and developed countries

    Kandelman, Daniel; Arpin, Sophie; Baez, Ramon J; Baehni, Pierre C; Petersen, Poul E

    Health care systems are essential for promoting, improving and maintaining health of the population. Through an efficient health service, patients can be advised of disease that may be present and so facilitate treatment; risks factors whose modification could reduce the incidence of disease and...... institutions or clinics may be equipped with the latest technical facilities. In developing countries, health services are mostly directed to provide emergency care only or interventions towards certain age group population. The most common diseases are dental caries and periodontal disease and frequently...... developed countries where the periodontal profile is also less than satisfactory. Despite the fact that in several developed countries there are advanced programmes oriented to periodontal disease treatments, the concern is related to the lack of preventive oriented treatments. According to data available...

  12. Development of Human System Integration at NASA

    Whitmore, Mihriban; McGuire, Kerry; Thompson, Shelby; Vos, Gordon

    2012-01-01

    Human Systems Integration seeks to design systems around the capabilities and limitations of the humans which use and interact with the system, ensuring greater efficiency of use, reduced error rates, and less rework in the design, manufacturing and operational deployment of hardware and software. One of the primary goals of HSI is to get the human factors practitioner involved early in the design process. In doing so, the aim is to reduce future budget costs and resources in redesign and training. By the preliminary design phase of a project nearly 80% of the total cost of the project is locked in. Potential design changes recommended by evaluations past this point will have little effect due to lack of funding or a huge cost in terms of resources to make changes. Three key concepts define an effective HSI program. First, systems are comprised of hardware, software, and the human, all of which operate within an environment. Too often, engineers and developers fail to consider the human capacity or requirements as part of the system. This leads to poor task allocation within the system. To promote ideal task allocation, it is critical that the human element be considered early in system development. Poor design, or designs that do not adequately consider the human component, could negatively affect physical or mental performance, as well as, social behavior. Second, successful HSI depends upon integration and collaboration of all the domains that represent acquisition efforts. Too often, these domains exist as independent disciplines due to the location of expertise within the service structure. Proper implementation of HSI through participation would help to integrate these domains and disciplines to leverage and apply their interdependencies to attain an optimal design. Via this process domain interests can be integrated to perform effective HSI through trade-offs and collaboration. This provides a common basis upon which to make knowledgeable decisions. Finally, HSI must be considered early in the requirements development phase of system design and acquisition. This will provide the best opportunity to maximize return on investment (ROI) and system performance. HSI requirements must be developed in conjunction with capability ]based requirements generation through functional. HSI requirements will drive HSI metrics and embed HSI issues within the system design. After a system is designed, implementation of HSI oversights can be very expensive. An HSI program should be included as an integral part of a total system approach to vehicle and habitat development. This would include, but not limited to, workstation design, D&C development, volumetric analysis, training, operations, and human -robotic interaction. HSI is a necessary process for Human Space Flight programs to meet the Agency Human ]System standards and thus mitigate human risks to acceptable levels. NASA has been involved in HSI planning, procedures development, process, and implementation for many years, and has been building several internal and publicly accessible products to facilitate HSI fs inclusion in the NASA Systems Engineering Lifecycle. Some of these products include: NASA STD 3001 Volumes 1 and 2, Human Integration Design Handbook, NASA HSI Implementation Plan, NASA HSI Implementation Plan Templates, NASA HSI Implementation Handbook, and a 2 ]hour short course on HSI delivered as part of the NASA Space and Life Sciences Directorate Academy. These products have been created leveraging industry best practices and lessons learned from other Federal Government agencies.

  13. Teaching Information Systems Development via Process Variants

    Tan, Wee-Kek; Tan, Chuan-Hoo

    2010-01-01

    Acquiring the knowledge to assemble an integrated Information System (IS) development process that is tailored to the specific needs of a project has become increasingly important. It is therefore necessary for educators to impart to students this crucial skill. However, Situational Method Engineering (SME) is an inherently complex process that

  14. System Transfer, Education, and Development in Mozambique

    Cossa, Jose

    2011-01-01

    In this study the author used conceptual historical method to assess the phenomenon of system transfer and the association between education and development in Mozambique. The assessment was administered through critical analysis of documents pertaining to the Salazar (1924-1966), Machel (1975-1986), and Chissano (1986-2005) administrations. The

  15. MPACT Fast Neutron Multiplicity System Prototype Development

    D.L. Chichester; S.A. Pozzi; J.L. Dolan; M.T. Kinlaw; S.J. Thompson; A.C. Kaplan; M. Flaska; A. Enqvist; J.T. Johnson; S.M. Watson

    2013-09-01

    This document serves as both an FY2103 End-of-Year and End-of-Project report on efforts that resulted in the design of a prototype fast neutron multiplicity counter leveraged upon the findings of previous project efforts. The prototype design includes 32 liquid scintillator detectors with cubic volumes 7.62 cm in dimension configured into 4 stacked rings of 8 detectors. Detector signal collection for the system is handled with a pair of Struck Innovative Systeme 16-channel digitizers controlled by in-house developed software with built-in multiplicity analysis algorithms. Initial testing and familiarization of the currently obtained prototype components is underway, however full prototype construction is required for further optimization. Monte Carlo models of the prototype system were performed to estimate die-away and efficiency values. Analysis of these models resulted in the development of a software package capable of determining the effects of nearest-neighbor rejection methods for elimination of detector cross talk. A parameter study was performed using previously developed analytical methods for the estimation of assay mass variance for use as a figure-of-merit for system performance. A software package was developed to automate these calculations and ensure accuracy. The results of the parameter study show that the prototype fast neutron multiplicity counter design is very nearly optimized under the restraints of the parameter space.

  16. Developing enzyme systems for biomass deconstruction

    The conversion of agricultural crops and residues to fermentable feedstock for the production of bioethanol represents a major source of renewable energy. The key to economically viable and effective biomass conversion includes the development of novel enzymes and enzyme systems to achieve total de...

  17. Developing a solar panel testing system

    Árpád Rácz; István A. Szabó; Lajos Harasztosi; Sándor Kökényesi

    2009-01-01

    Solar energy is increasingly used togenerate electricity for individual households. There isa wide variety of solar panel technologies, whichshould be tested at an individual level during theirlifetime. In this paper, the development of a testingstation at the University of Debrecen is presented. Thetesting system can be used for research andeducational purposes and for in field applicationsequally well.

  18. Teaching Information Systems Development via Process Variants

    Tan, Wee-Kek; Tan, Chuan-Hoo

    2010-01-01

    Acquiring the knowledge to assemble an integrated Information System (IS) development process that is tailored to the specific needs of a project has become increasingly important. It is therefore necessary for educators to impart to students this crucial skill. However, Situational Method Engineering (SME) is an inherently complex process that…

  19. Developing a solar panel testing system

    Árpád Rácz

    2009-10-01

    Full Text Available Solar energy is increasingly used togenerate electricity for individual households. There isa wide variety of solar panel technologies, whichshould be tested at an individual level during theirlifetime. In this paper, the development of a testingstation at the University of Debrecen is presented. Thetesting system can be used for research andeducational purposes and for in field applicationsequally well.

  20. Development of the Guardian environmental monitoring system

    The report describes the Guardian Environmental Monitoring System, developed jointly by the CEGB's Berkeley Nuclear Laboratories (BNL) and GEC Energy Systems Limited (ESL). The basic battery operated instrument was developed by BNL for the measurement of any nuclear facility contribution to the overall environmental dose. It uses an energy compensated Geiger counter to provide a continuous record for over a month of dose rates from 1 μR h-1 (10nGy h-1). Results are presented of initial development trials and of an intercomparison with the USA Environmental Measurement Laboratory. The Guardian system, however, was developed, not only to meet the CEGB requirements for a recording monitor, but also to meet the requirements of US Regulatory Commission Guide RG 1.97, introduced as a result of the accident at Three Mile Island. This system, by using two energy compensated Geiger counters has a range from 1μRh-1 up to 10Rh-1 (approximately equal to 100mGyh-1), and the associated electronics provides automatic range changing, including fast response to ramp exposure rate changes, alarm and test facilities and telemetry by line or radio to a central station. (author)

  1. A Systems Approach to Management Development

    Somerville, James D.

    1974-01-01

    A systems approach to management development in today's business world becomes more than a theoretical diagram of how things should work or just a training program. It is an assessment of a company's strengths and weaknesses and should be a prelude to successful business planning. (Author/DS)

  2. Developing a Package Training System for Industry

    Battersby, D. L. N.

    1974-01-01

    The hotel and catering industry is one of Great Britain's largest. A packaged training system has been developed to satisfy the needs of this industry, an ever-growing occupational field with multiple categories. The material provided in each package outlines short pieces of instruction and helps the trainer create appropriate training. (DS)

  3. The Systems Theory Framework of Career Development

    McMahon, Mary

    2011-01-01

    The Systems Theory Framework (STF; McMahon & Patton, 1995; Patton & McMahon, 2006) of career development was proposed as a metatheoretical framework that accommodates the contribution of all theories and offers an integrative and coherent framework of career influences. In this article, the author provides an overview of the STF, outlines its…

  4. Developing aircraft photonic networks for airplane systems

    White, Henry J.; Brownjohn, Nick; Baptista, João; Foucal, Vincent; Salgado, Henrique; Clausen, Anders; Pistner, Thomas; Farries, Mark; Gauchy, Stéphane; Kopacek, Ilja; Lee, Andrew; Napier, Bruce; Traversone, Massimo; Vincent, James; Zimmermann, Armin

    2013-01-01

    Achieving affordable high speed fiber optic communication networks for airplane systems has proved to be challenging. In this paper we describe a summary of the EU Framework 7 project DAPHNE (Developing Aircraft Photonic Networks). DAPHNE aimed to exploit photonic technology from terrestrial...

  5. Development of an advanced robot manipulator system

    A sophisticated manipulator system for an advanced robot was developed under the 'Advanced Robot Technology Development' Program promoted and supported by the Agency of Industrial Science and Technology of MITI. The authors have participated in the development of a fingered manipulator with force and tactile sensors applicable to a masterslave robot system. Our slave manipulator is equipped with four fingers. Though the finger needs many degrees of freedom so as to be suitable for skilful handing of an object, our fingers are designed to have minimum degree of freedom in order to reduce weight. Each finger tip was designed to be similar to a human finger which has flexibility, softness and contact feeling. The shape of the master finger manipulator was so designed that the movement of the fingers is smoother and that the constraint feeling of the operator is smaller. We were adopted to a pneumatic pressure system for transmitting the tactile feeling of the slave fingers to the master fingers. A multiple sensory bilateral control system which gives an operator a feeling of force and tactile reduces his feeling of constraint in carrying out work with a robot system. (author)

  6. Development of Arduino based wireless control system

    Sun, Zhuoxiong; Dyke, Shirley J.; Pena, Francisco; Wilbee, Alana

    2015-03-01

    Over the past few decades, considerable attention has been given to structural control systems to mitigate structural vibration under natural hazards such as earthquakes and extreme weather conditions. Traditional wired structural control systems often employ a large amount of cables for communication among sensors, controllers and actuators. In such systems, implementation of wired sensors is usually quite complicated and expensive, especially on large scale structures such as bridges and buildings. To reduce the laborious installation and maintenance cost, wireless control systems (WCSs) are considered as a novel approach for structural vibration control. In this work, a WCS is developed based on the open source Arduino platform. Low cost, low power wireless sensing and communication components are built on the Arduino platform. Structural control algorithms are embedded within the wireless sensor board for feedback control. The developed WCS is first validated through a series of tests. Next, numerical simulations are performed simulating wireless control of a 3-story shear structure equipped with a semi-active control device (MR damper). Finally, experimental studies are carried out implementing the WCS on the 3-story shear structure in the Intelligent Infrastructure Systems Lab (IISL). A hydraulic shake table is used to generate seismic ground motions. The control performance is evaluated with the impact of modeling uncertainties, measurement noises as well as time delay and data loss induced by the wireless network. The developed WCS is shown to be effective in controlling structural vibrations under several historical earthquake ground motions.

  7. Advanced Turbine Systems Program industrial system concept development

    Gates, S. [Solar Turbines Inc., San Diego, CA (United States)

    1995-10-01

    The objective of Phase II of the Advanced Turbine Systems Program is to develop conceptual designs of gas fired advanced turbine systems that can be adapted for operation on coal and biomass fuels. The technical, economic, and environmental performance operating on natural gas and in a coal fueled mode is to be assessed. Detailed designs and test work relating to critical components are to be completed and a market study is to be conducted.

  8. Advanced CIDI Emission Control System Development

    Lambert, Christine

    2006-05-31

    Ford Motor Company, with ExxonMobil and FEV, participated in the Department of Energy's (DOE) Ultra-Clean Transportation Fuels Program with the goal to develop an innovative emission control system for light-duty diesel vehicles. The focus on diesel engine emissions was a direct result of the improved volumetric fuel economy (up to 50%) and lower CO2 emissions (up to 25%) over comparable gasoline engines shown in Europe. Selective Catalytic Reduction (SCR) with aqueous urea as the NOx reductant and a Catalyzed Diesel Particulate Filter (CDPF) were chosen as the primary emission control system components. The program expected to demonstrate more than 90% durable reduction in particulate matter (PM) and NOx emissions on a light-duty truck application, based on the FTP-75 drive cycle. Very low sulfur diesel fuel (<15 ppm-wt) enabled lower PM emissions, reduced fuel economy penalty due to the emission control system and improved long-term system durability. Significant progress was made toward a durable system to meet Tier 2 Bin 5 emission standards on a 6000 lbs light-duty truck. A 40% reduction in engine-out NOx emissions was achieved with a mid-size prototype diesel engine through engine recalibration and increased exhaust gas recirculation. Use of a rapid warm-up strategy and urea SCR provided over 90% further NOx reduction while the CDPF reduced tailpipe PM to gasoline vehicle levels. Development work was conducted to separately improve urea SCR and CDPF system durability, as well as improved oxidation catalyst function. Exhaust gas NOx and ammonia sensors were also developed further. While the final emission control system did not meet Tier 2 Bin 5 NOx after 120k mi of aging on the dynamometer, it did meet the standards for HC, NMOG, and PM, and an improved SCR catalyst was shown to have potential to meet the NOx standard, assuming the DOC durability could be improved further. Models of DOC and SCR function were developed to guide the study of several key design factors for SCR systems and aid in the development of urea control strategy for maximum NOx reduction with minimum NH3 slip. A durable co-fueling system was successfully built and tested, with the help of service station nozzle and dispenser manufacturers, for simultaneous delivery of diesel fuel and aqueous urea to the vehicle. The business case for an aqueous urea infrastructure in the US for light-duty vehicles was explored.

  9. Solid oxide fuel cell power system development

    Kerr, Rick [Delphi Automotive Systems, LLC., Troy, MI (United States); Wall, Mark [Independent Energy Partners Technology, LLC., Parker, CO (United States); Sullivan, Neal [Colorado School of Mines, Golden, CO (United States)

    2015-06-26

    This report summarizes the progress made during this contractual period in achieving the goal of developing the solid oxide fuel cell (SOFC) cell and stack technology to be suitable for use in highly-efficient, economically-competitive, commercially deployed electrical power systems. Progress was made in further understanding cell and stack degradation mechanisms in order to increase stack reliability toward achieving a 4+ year lifetime, in cost reduction developments to meet the SECA stack cost target of $175/kW (in 2007 dollars), and in operating the SOFC technology in a multi-stack system in a real-world environment to understand the requirements for reliably designing and operating a large, stationary power system.

  10. Research and Development Management System (RDMS)

    Research and Development (R and D) is a main activity carried out at the Malaysian Nuclear Agency particularly in the physical science and nuclear field. The R and D activity that is carried out needs to be managed more efficiently and systematically. Until now all research management activities are carried out manually or semi electronically, beginning from filling in application forms to when the project is completed. Therefore a computerized system is needed in order to manage and monitor R and D projects. The R and D system is capable of giving access information concerning R and D projects which are carried out to users inside and outside the agency. The R and D management system (RDMS) can increase the capability of the Malaysian Nuclear Agency in managing, researching and developing, innovating and inventing technology as well as commercializing the R and D produced. (author)

  11. Development of radiation detection and measurement systems

    Moon, B. S.; Ham, C. S.; Chung, C. E. and others

    2000-03-01

    This report contains descriptions on the following six items. The first item is the result of a study on CsI(TI) crystals with their light emitting characteristics and the result of a study on plastic scintillators. The second item is the result of a study on advanced radiation detectors and includes experiments for the effect of using a Compton suppressor with an HPGe detector. For the third item, we describe the results of a design work done using EGS4 for a thickness gauge, a density gauge, and a level gauge. The fourth item contains descriptions on the prototype circuit systems developed for a level gauge, a thickness gauge, and for a survey meter. The fifth part contains the computed tomography algorithm and a prototype scanning system developed for a CT system. As the sixth and the last item, we describe the prototype high precision heat source and the prototype heat-voltage converter which we have designed and fabricated.

  12. Development of radiation detection and measurement systems

    This report contains descriptions on the following six items. The first item is the result of a study on CsI(TI) crystals with their light emitting characteristics and the result of a study on plastic scintillators. The second item is the result of a study on advanced radiation detectors and includes experiments for the effect of using a Compton suppressor with an HPGe detector. For the third item, we describe the results of a design work done using EGS4 for a thickness gauge, a density gauge, and a level gauge. The fourth item contains descriptions on the prototype circuit systems developed for a level gauge, a thickness gauge, and for a survey meter. The fifth part contains the computed tomography algorithm and a prototype scanning system developed for a CT system. As the sixth and the last item, we describe the prototype high precision heat source and the prototype heat-voltage converter which we have designed and fabricated

  13. Development of technical information processing systems

    The major goal of this project is to develop a more efficient information management system by connecting the KAREI serials database which enable the users to access from their own laboratory facilities through KAREI-NET. The importance of this project is to make the serials information of KAERI easily accessible to users as valuable resources for R and D activities. The results of the project are as follows. 1) Development of the serials database and retrieval system enabled us to access to the serials holding information through KAERI-NET. 2) The database construction establishes a foundation for the management of 1,600 serials held in KAERI. 3) The system can be applied not only to KAERI but also to similar medium-level libraries. (Author)

  14. Expert system for developing multivariate calibrations

    Aries, R. E.; Lidiard, D. P.; Spragg, R. A.

    1994-01-01

    The introduction of multivariate methods such as PCR and PLS has considerably extended the scope of quantitative FT-IR analysis. However method development is now an area for specialists who can interpret the wealth of diagnostic information generated by current chemometric software packages. Inexperienced users are faced with so much information that they simply do not know where to start. We have developed a rule-based system that uses this information in an iterative procedure to develop calibrations automatically. The main task is to identify and eliminate outliers of various types, namely spectra, variables and property values. The system is capable of generating robust calibrations from data sets containing multiple errors, using either PCR or PLS.

  15. Scaling Health Information Systems in Developing Countries

    Mengiste, Shegaw Anagaw; Neilsen, Petter

    2006-01-01

    This article addresses the issues of scaling health information system in the context of developing countries by taking a case study from Ethiopia. Concepts of information infrastructure have been used as an analytical lens to better understand scaling of Health Information systems. More......) building as an intertwined process of the evolution of the installed base and the construction activities of human agents. Overall, we argue that it is not only the adverse situation that determines how things develop, but HII builders need to navigate and take into account a wide range of issues related...... to the installed base. The relative strength between the proponents of a HIS and the installed base will vary and thus require different approaches. While the II may develop and evolve as it is out of control from time to time, this study shows that there is also room for II building activities at...

  16. Development of compact CCTV surveillance system. 'COSMOS'

    The Compact Surveillance and Monitoring System, 'COSMOS' has been developed as a compact, simple, highly reliable CCTV surveillance system. The system is intended to provide a direct replacement for the IAEA Twin Minolta film camera systems. The system consists of a recording unit and a set up/review unit. The recording unit, consisting of a CCD camera module, a 8mm VTR unit, a controller module and a power unit, is contained in a tamper indicating housing. The VTR module of very low power consumption is specially developed for COSMOS capable of battery operation. The system can be operated for three months either by battery without battery change where mains power is not readily available or by AC powers. The field-use model of COSMOS was completed in 1991. The field-evaluation test by the IAEA and JAERI was successfully completed in 1993. The IAEA accepted the COSMOS as a routine-use device in August 1993. This report describes the performance features and IAEA test result of COSMOS. (author)

  17. Development of an Integrated Distribution Management System

    Schatz, Joe E.

    2010-10-20

    This final report details the components, functionality, costs, schedule and benefits of developing an Integrated Distribution Management System (IDMS) for power distribution system operation. The Distribution Automation (DA) and Supervisory Control and Data Acquisition (SCADA) systems used by electric power companies to manage the distribution of electric power to retail energy consumers are vital components of the Nation’s critical infrastructure. Providing electricity is an essential public service and a disruption in that service, if not quickly restored, could threaten the public safety and the Nation’s economic security. Our Nation’s economic prosperity and quality of life have long depended on the essential services that utilities provide; therefore, it is necessary to ensure that electric utilities are able to conduct their operations safely and efficiently. A fully integrated technology of applications is needed to link various remote sensing, communications and control devices with other information tools that help guide Power Distribution Operations personnel. A fully implemented IDMS will provide this, a seamlessly integrated set of applications to raise electric system operating intelligence. IDMS will enhance DA and SCADA through integration of applications such as Geographic Information Systems, Outage Management Systems, Switching Management and Analysis, Operator Training Simulator, and other Advanced Applications, including unbalanced load flow and fault isolation/service restoration. These apps are capable of utilizing and obtaining information from appropriately installed DER, and by integrating disparate systems, the Distribution Operators will benefit from advanced capabilities when analyzing, controlling and operating the electric system.

  18. Development of a Universal Waste Management System

    Stapleton, Thomas J.; Baccus, Shelley; Broyan, James L., Jr.

    2013-01-01

    NASA is working with a number of commercial companies to develop the next low Earth orbit spacecraft. The hardware volume and weight constraints are similar to or greater than those of the Apollo era. This, coupled with the equally demanding cost challenge of the proposed commercial vehicles, causes much of the Environmental Control and Life Support System (ECLSS) designs to be reconsidered. The Waste Collection System (WCS) is within this group of ECLSS hardware. The development to support this new initiative is discussed within. A WCS concept - intended to be common for all the vehicle platforms currently on the drawing board - is being developed. The new concept, referred to as the Universal Waste Management System (UWMS), includes favorable features from previous designs while improving on other areas on previous Space Shuttle and the existing International Space Station (ISS) WCS hardware, as needed. The intent is to build a commode that requires less crew time, improved cleanliness, and a 75% reduction in volume and weight compared to the previous US ISS/Extended Duration Orbitor WCS developed in the 1990s. The UWMS is most similar to the ISS Development Test Objective (DTO) WCS design. It is understood that the most dramatic cost reduction opportunity occurs at the beginning of the design process. To realize this opportunity, the cost of each similar component between the UWMS and the DTO WCS was determined. The comparison outlined were the design changes that would result with the greatest impact. The changes resulted in simplifying the approach or eliminating components completely. This initial UWMS paper will describe the system layout approach and a few key features of major components. Future papers will describe the UWMS functionality, test results, and components as they are developed.

  19. J-2X Abort System Development

    Santi, Louis M.; Butas, John P.; Aguilar, Robert B.; Sowers, Thomas S.

    2008-01-01

    The J-2X is an expendable liquid hydrogen (LH2)/liquid oxygen (LOX) gas generator cycle rocket engine that is currently being designed as the primary upper stage propulsion element for the new NASA Ares vehicle family. The J-2X engine will contain abort logic that functions as an integral component of the Ares vehicle abort system. This system is responsible for detecting and responding to conditions indicative of impending Loss of Mission (LOM), Loss of Vehicle (LOV), and/or catastrophic Loss of Crew (LOC) failure events. As an earth orbit ascent phase engine, the J-2X is a high power density propulsion element with non-negligible risk of fast propagation rate failures that can quickly lead to LOM, LOV, and/or LOC events. Aggressive reliability requirements for manned Ares missions and the risk of fast propagating J-2X failures dictate the need for on-engine abort condition monitoring and autonomous response capability as well as traditional abort agents such as the vehicle computer, flight crew, and ground control not located on the engine. This paper describes the baseline J-2X abort subsystem concept of operations, as well as the development process for this subsystem. A strategy that leverages heritage system experience and responds to an evolving engine design as well as J-2X specific test data to support abort system development is described. The utilization of performance and failure simulation models to support abort system sensor selection, failure detectability and discrimination studies, decision threshold definition, and abort system performance verification and validation is outlined. The basis for abort false positive and false negative performance constraints is described. Development challenges associated with information shortfalls in the design cycle, abort condition coverage and response assessment, engine-vehicle interface definition, and abort system performance verification and validation are also discussed.

  20. EXPERT SYSTEMS - DEVELOPMENT OF AGRICULTURAL INSURANCE TOOL

    NAN Anca-Petruţa

    2013-07-01

    Full Text Available Because of the fact that specialty agricultural assistance is not always available when the farmers need it, we identified expert systems as a strong instrument with an extended potential in agriculture. This started to grow in scale recently, including all socially-economic activity fields, having the role of collecting data regarding different aspects from human experts with the purpose of assisting the user in the necessary steps for solving problems, at the performance level of the expert, making his acquired knowledge and experience available. We opted for a general presentation of the expert systems as well as their necessity, because, the solution to develop the agricultural system can come from artificial intelligence by implementing the expert systems in the field of agricultural insurance, promoting existing insurance products, farmers finding options in depending on their necessities and possibilities. The objective of this article consists of collecting data about different aspects about specific areas of interest of agricultural insurance, preparing the database, a conceptual presentation of a pilot version which will become constantly richer depending on the answers received from agricultural producers, with the clearest exposure of knowledgebase possible. We can justify picking this theme with the fact that even while agricultural insurance plays a very important role in agricultural development, the registered result got from them are modest, reason why solutions need to be found in the scope of developing the agricultural sector. The importance of this consists in the proposal of an immediate viable solution to correspond with the current necessities of agricultural producers and in the proposal of an innovative solution, namely the implementation of expert system in agricultural insurance as a way of promoting insurance products. Our research, even though it treats the subject at an conceptual level, it wants to undertake an attempt to present the necessity and importance of implementing expert systems in agricultural insurance as a solution of development of the Romanian agricultural sector since insurance play an important role in the stimulation of investments in agriculture and in the stabilization of agricultural producers incomes. The results of the study, at a conceptual level, confirms the necessity of aplying expert systems in agricultural insurance because of the benefits which would be created (informing agricultural producers about the existence and importance of agricultural insurance, the development of the insurance market which would lead to the development of agriculture, creation of new insurance products adapted to the needs of the farmers.

  1. Thermal Protection System (Heat Shield) Development - Advanced Development Project

    Kowal, T. John

    2010-01-01

    The Orion Thermal Protection System (TPS) ADP was a 3 1/2 year effort to develop ablative TPS materials for the Orion crew capsule. The ADP was motivated by the lack of available ablative TPS's. The TPS ADP pursued a competitive phased development strategy with succeeding rounds of development, testing and down selections. The Project raised the technology readiness level (TRL) of 8 different TPS materials from 5 different commercial vendors, eventual down selecting to a single material system for the Orion heat shield. In addition to providing a heat shield material and design for Orion on time and on budget, the Project accomplished the following: 1) Re-invigorated TPS industry & re-established a NASA competency to respond to future TPS needs; 2) Identified a potentially catastrophic problem with the planned MSL heat shield, and provided a viable, high TRL alternate heat shield design option; and 3) Transferred mature heat shield material and design options to the commercial space industry, including TPS technology information for the SpaceX Dragon capsule.

  2. APS storage ring vacuum system development

    The Advanced Photon Source synchrotron radiation facility, under construction at the Argonne National Laboratory, incorporates a large ring for the storage of 7 GeV positrons for the generation of photon beams for the facility's materials research program. The Storage Ring's 1104 m circumference is divided into 40 sectors which contain vacuum, beam transport, control, rf and insertion device systems. The vacuum system will operate at a pressure of 1 nTorr and is fabricated from aluminum. The system includes distributed NeG pumping, photon absorbers with lumped pumping, beam position monitors, vacuum diagnostics and valving. An overview of the vacuum system design and details of selected development program results are presented. 5 refs

  3. Developing 360 degree feedback system for KINS

    This project aims to investigate the feasibility of a 360 degree feedback systems for KINS and to design guiding rules and structures in implementing that systems. Literature survey, environmental analysis and questionnaire survey were made to ensure that 360 degree feedback is the right tool to improve performance in KINS. That review leads to conclusion that more readiness and careful feasibility review are needed before implementation of 360 degree feedback in KINS. Further the project suggests some guiding rules that can be helpful for successful implementation of that system in KINS. Those include : start with development, experiment with one department, tie it to a clear organization's goal, train everyone involve, make sure to try that system in an atmosphere of trust

  4. MPC system development a utility industry assessment

    The Department of Energy is currently pursuing development of a Multi Purpose Container System (MPCS) which would serve as a standardized packaging approach for bringing the nation's spent nuclear fuel from the utility sites into the federal spent fuel management system. Specifically, this system will enhance integration of the transportation, interim storage, and disposal components of the waste program. Such integration and standardization should result in economic and operations benefits to the Waste Disposal System. Consequently, the Nuclear Industry is very supportive of the effort. This project will clearly create extensive interface challenges which must be overcome. An ongoing cooperative effort between the utilities, the DOE, and associated contractors will be necessary to ensure an optimum design and successful deployment

  5. Development of an advanced strapdown inertial system

    Schad, V. R.; Silva, F. A. R.; Pires, C. L. G.

    Attention is given to the development of a laboratory model of an airborne computer associated with a strapdown gyro unit manufactured by an U.S. aerospace company. The considered system should satisfy the requirements for a small satellite launcher. The inertial unit includes two dry tuned-rotor gyros and two-scale digitizers. The computing system includes a 8087 numeric coprocessor and an 8086 16-bit processor. The 8087 implements with high speed and precision floating-point operations including trigonometric functions. The algorithm for the computer is discussed, taking into account the use of the quaternion method for obtaining attitude information. In an evaluation of the merits of the selected computing system it is pointed out that the availability of low cost high performance numeric processors gives the sounding rocket community the possibility of using a powerful airborne computer of standard design, with enough capability to implement a strapdown inertial reference system.

  6. Developing 360 degree feedback system for KINS

    Han, In Soo; Cheon, B. M.; Kim, T. H.; Ryu, J. H. [Chungman National Univ., Daejeon (Korea, Republic of)

    2003-12-15

    This project aims to investigate the feasibility of a 360 degree feedback systems for KINS and to design guiding rules and structures in implementing that systems. Literature survey, environmental analysis and questionnaire survey were made to ensure that 360 degree feedback is the right tool to improve performance in KINS. That review leads to conclusion that more readiness and careful feasibility review are needed before implementation of 360 degree feedback in KINS. Further the project suggests some guiding rules that can be helpful for successful implementation of that system in KINS. Those include : start with development, experiment with one department, tie it to a clear organization's goal, train everyone involve, make sure to try that system in an atmosphere of trust.

  7. Development of the real time monitor system

    Large-scale simulation technique is studied at the Center for Promotion of Computational Science and Engineering (CCSE) for the computational science research in nuclear fields. Visualization and animation processing technique are studied and developed for efficient understanding of simulation results. The real time monitor system, in which on-going simulation results are transferred from a supercomputer or workstation to a graphic workstation and are visualized and recorded, is described in this report. This system is composed of the graphic workstation and the video equipment connected to the network. The control shell programs are the job-execution shell for simulations on supercomputers, the file-transfer shell for output files for visualization, and the shell for starting visualization tools. Special image processing technique and hardware are not necessary in this system and the standard visualization tool AVS and the UNIX commands are used, so that this system can be implemented and applied in various computer environments. (author)

  8. HELIAS module development for systems codes

    In order to study and design next-step fusion devices such as DEMO, comprehensive systems codes are commonly employed. In this work HELIAS-specific models are proposed which are designed to be compatible with systems codes. The subsequently developed models include: a geometry model based on Fourier coefficients which can represent the complex 3-D plasma shape, a basic island divertor model which assumes diffusive cross-field transport and high radiation at the X-point, and a coil model which combines scaling aspects based on the HELIAS 5-B reactor design in combination with analytic inductance and field calculations. In addition, stellarator-specific plasma transport is discussed. A strategy is proposed which employs a predictive confinement time scaling derived from 1-D neoclassical and 3-D turbulence simulations. This paper reports on the progress of the development of the stellarator-specific models while an implementation and verification study within an existing systems code will be presented in a separate work. This approach is investigated to ultimately allow one to conduct stellarator system studies, develop design points of HELIAS burning plasma devices, and to facilitate a direct comparison between tokamak and stellarator DEMO and power plant designs

  9. Requirements development for a patient computing system.

    Wald, J S; Pedraza, L A; Reilly, C A; Murphy, M E; Kuperman, G J

    2001-01-01

    Critical parts of the software development life cycle are concerned with eliciting, understanding, and managing requirements. Though the literature on this subject dates back for several decades, practicing effective requirements development remains a current and challenging area. Some projects flourish with a requirements development process (RDP) that is implicit and informal, but this approach may be overly risky, particularly for large projects that involve multiple individuals, groups, and systems over time. At Partners HealthCare System in Boston, Massachusetts, we have applied a more formal approach for requirements development to the Patient Computing Project. The goal of the project is to create web-based software that connects patients electronically with their physician's offices and has the potential to improve care efficiency and quality. It is a large project, with over 500 function points. Like most technological innovation, the successful introduction of this system requires as much attention to understanding the business needs and workflow details as it does to technical design and implementation. This paper describes our RDP approach, and key business requirements discovered through this process. We believe that a formal RDP is essential, and that informatics as a field must include proficiencies in this area. PMID:11825282

  10. Offshore Wind Energy Systems Engineering Curriculum Development

    McGowan, Jon G. [Univ. of Massachusetts, Amherst, MA (United States); Manwell, James F. [Univ. of Massachusetts, Amherst, MA (United States); Lackner, Matthew A. [Univ. of Massachusetts, Amherst, MA (United States)

    2012-12-31

    Utility-scale electricity produced from offshore wind farms has the potential to contribute significantly to the energy production of the United States. In order for the U.S. to rapidly develop these abundant resources, knowledgeable scientists and engineers with sound understanding of offshore wind energy systems are critical. This report summarizes the development of an upper-level engineering course in "Offshore Wind Energy Systems Engineering." This course is designed to provide students with a comprehensive knowledge of both the technical challenges of offshore wind energy and the practical regulatory, permitting, and planning aspects of developing offshore wind farms in the U.S. This course was offered on a pilot basis in 2011 at the University of Massachusetts and the National Renewable Energy Laboratory (NREL), TU Delft, and GL Garrad Hassan have reviewed its content. As summarized in this report, the course consists of 17 separate topic areas emphasizing appropriate engineering fundamentals as well as development, planning, and regulatory issues. In addition to the course summary, the report gives the details of a public Internet site where references and related course material can be obtained. This course will fill a pressing need for the education and training of the U.S. workforce in this critically important area. Fundamentally, this course will be unique due to two attributes: an emphasis on the engineering and technical aspects of offshore wind energy systems, and a focus on offshore wind energy issues specific to the United States.

  11. Development of Carbon Dioxide Removal Systems for Advanced Exploration Systems

    Knox, James C.; Trinh, Diep; Gostowski, Rudy; King, Eric; Mattox, Emily M.; Watson, David; Thomas, John

    2012-01-01

    "NASA's Advanced Exploration Systems (AES) program is pioneering new approaches for rapidly developing prototype systems, demonstrating key capabilities, and validating operational concepts for future human missions beyond Earth orbit" (NASA 2012). These forays beyond the confines of earth's gravity will place unprecedented demands on launch systems. They must not only blast out of earth's gravity well as during the Apollo moon missions, but also launch the supplies needed to sustain a crew over longer periods for exploration missions beyond earth's moon. Thus all spacecraft systems, including those for the separation of metabolic carbon dioxide and water from a crewed vehicle, must be minimized with respect to mass, power, and volume. Emphasis is also placed on system robustness both to minimize replacement parts and ensure crew safety when a quick return to earth is not possible. Current efforts are focused on improving the current state-of-the-art systems utilizing fixed beds of sorbent pellets by seeking more robust pelletized sorbents, evaluating structured sorbents, and examining alternate bed configurations to improve system efficiency and reliability. These development efforts combine testing of sub-scale systems and multi-physics computer simulations to evaluate candidate approaches, select the best performing options, and optimize the configuration of the selected approach, which is then implemented in a full-scale integrated atmosphere revitalization test. This paper describes the carbon dioxide (CO2) removal hardware design and sorbent screening and characterization effort in support of the Atmosphere Resource Recovery and Environmental Monitoring (ARREM) project within the AES program. A companion paper discusses development of atmosphere revitalization models and simulations for this project.

  12. Development of the Medium Energy Linac Systems

    The main purpose of this project is developing 100-MeV proton linear accelerator (linac) for proton engineering frontier project (PEFP). In the first phase of the PEFP, the development of the 20-MeV linac has successfully finished. Hence the work scope of this project is designing the linac to accelerate proton beams from 20-MeV up to 100-MeV, fabricating the linac up to 45 MeV, fabricating one set of the medium energy beam transport (MEBT) tank, and developing the low level radio frequency (LLRF) system and the control system. The basic role of the new proton accelerator is accelerating 20-mA proton beams from 20 MeV up to 100 MeV. The first step of the design procedure is optimizing and determining the accelerator parameters. The beam loss is also main concern in the design stage. The drift tube (DT) and the quadrupole magnets are designed to be optimized to the new linac design. The other purpose is confirming the new design by fabricating and tuning the drift tube linac (DTL). The 20MeV proton beam divided into two directions. One is supplying the beams to user group by turning on the 45-degree bending magnet. The other is guided into the 100-MeV DTL by tuning off the dipole magnet. That is why the PEFP MEBT located after 20-MeV DTL. The MEBT is realized as two small DTL tanks with three cells and a 45-degree bending magnet. The fabrication of one MEBT tank is another purpose of this project. The other purposes of this project is developing the LLRF system to control the RF signal and control system to monitor and control the vacuum system, magnet power supply, etc

  13. Development of FBR cycle data base system

    In the 'Feasibility Study on Commercialized Fast Reactor Cycle System (F/S)'. scenario evaluations, cost-benefit evaluations and system characteristic evaluations to show significance of the Fast Breeder Reactor (FBR) cycle system introduction concretely are performed in parallel with a design study for FBR plants, reprocessing systems and fabrication systems. In these evaluations, informations such as economic prospects, prospects for supply and demand of resources and a progress of engineering development are used in addition to design information. This report explains a FBR Cycle Database in order to carry out management and search of various design information and the relating information. The prototype system of the database was completed in the 2000 fiscal year, and the problem of the user number restriction of the prototype system has been improved by Web-ization in the 2001 fiscal year. About 7,000 data are stored in this data base (as of the end of March, 2002). The expansion of user etc., and the continuation of input work of various evaluation information will be carried out, in the phase 2 of F/S. (author)

  14. Sensor Development for PEM Fuel Cell Systems

    Steve Magee; Richard Gehman

    2005-07-12

    This document reports on the work done by Honeywell Sensing and Control to investigate the feasibility of modifying low cost Commercial Sensors for use inside a PEM Fuel Cell environment. Both stationary and automotive systems were considered. The target environment is hotter (100 C) than the typical commercial sensor maximum of 70 C. It is also far more humid (100% RH condensing) than the more typical 95% RH non-condensing at 40 C (4% RH maximum at 100 C). The work focused on four types of sensors, Temperature, Pressure, Air Flow and Relative Humidity. Initial design goals were established using a market research technique called Market Driven Product Definition (MDPD). A series of interviews were conducted with various users and system designers in their facilities. The interviewing team was trained in data taking and analysis per the MDPD process. The final result was a prioritized and weighted list of both requirements and desires for each sensor. Work proceeded on concept development for the 4 types of sensors. At the same time, users were developing the actual fuel cell systems and gaining knowledge and experience in the use of sensors and controls systems. This resulted in changes to requirements and desires that were not anticipated during the MDPD process. The concepts developed met all the predicted requirements. At the completion of concept development for the Pressure Sensor, it was determined that the Fuel Cell developers were happy with off-the-shelf automotive pressure sensors. Thus, there was no incentive to bring a new Fuel Cell Specific Pressure Sensor into production. Work was therefore suspended. After the experience with the Pressure Sensor, the requirements for a Temperature Sensor were reviewed and a similar situation applied. Commercially available temperature sensors were adequate and cost effective and so the program was not continued from the Concept into the Design Phase.

  15. ARM System Developer's Guide Designing and Optimizing System Software

    Sloss, Andrew

    2004-01-01

    Over the last ten years, the ARM architecture has become one of the most pervasive architectures in the world, with more than 2 billion ARM-based processors embedded in products ranging from cell phones to automotive braking systems. A world-wide community of ARM developers in semiconductor and product design companies includes software developers, system designers and hardware engineers. To date no book has directly addressed their need to develop the system and software for an ARM-based system. This text fills that gap. This book provides a comprehensive description of the operation of the ARM core from a developer's perspective with a clear emphasis on software. It demonstrates not only how to write efficient ARM software in C and assembly but also how to optimize code. Example code throughout the book can be integrated into commercial products or used as templates to enable quick creation of productive software. The book covers both the ARM and Thumb instruction sets, covers Intel''s XScale Processors, ou...

  16. Oral health care systems in developing and developed countries

    Kandelman, Daniel; Arpin, Sophie; Baez, Ramon J; Baehni, Pierre C; Petersen, Poul E

    intervention procedures aim, at treating existing problems and restore teeth and related structure to normal function. It is unfortunate that the low priority given to oral health hinders acquisition of data and establishment of effective periodontal care programmes in developing countries but also in some......Health care systems are essential for promoting, improving and maintaining health of the population. Through an efficient health service, patients can be advised of disease that may be present and so facilitate treatment; risks factors whose modification could reduce the incidence of disease and...... institutions or clinics may be equipped with the latest technical facilities. In developing countries, health services are mostly directed to provide emergency care only or interventions towards certain age group population. The most common diseases are dental caries and periodontal disease and frequently...

  17. Equipment system for advanced nuclear fuel development

    The purpose of the settlement of equipment system for nuclear Fuel Technology Development Facility(FTDF) is to build a seismic designed facility that can accommodate handling of nuclear materials including <20% enriched Uranium and produce HANARO fuel commercially, and also to establish the advanced common research equipment essential for the research on advanced fuel development. For this purpose, this research works were performed for the settlement of radiation protection system and facility special equipment for the FTDF, and the advanced common research equipment for the fuel fabrication and research. As a result, 11 kinds of radiation protection systems such as criticality detection and alarm system, 5 kinds of facility special equipment such as environmental pollution protection system and 5 kinds of common research equipment such as electron-beam welding machine were established. By the settlement of exclusive domestic facility for the research of advanced fuel, the fabrication and supply of HANARO fuel is possible and also can export KAERI-invented centrifugal dispersion fuel materials and its technology to the nations having research reactors in operation. For the future, the utilization of the facility will be expanded to universities, industries and other research institutes

  18. Development of clean chemical mechanical polishing systems; Clean CMP system

    Tsujimura, M.; Hosokawa, M. [Ebara Corp., Tokyo (Japan)

    1998-10-20

    Described herein are clean chemical mechanical polishing (CMP) systems developed by Ebara. A CMP system needs advanced peripheral techniques, in addition to those for grinding adopted by the conventional system, in order to fully exhibit its inherent functions. An integrated design concept is essential for the CMP steps, including slurry supplying, polishing, washing, process controlling and waste fluid treatment. The Ebara has adopted a standard concept `Clean CMP, dry-in and dry-out of wafers,` and provided world`s highest grades of techniques for inter-layer insulating film, shallow trench isolation, plug and wiring. The head for the polishing module is specially designed by FEM, to improve homogeneity of wafers from the center to edges. The dresser is also specially designed, to improve pad surface topolody after dressing. A slurry dipsersing method is developed to reduce slurry consumption. Various washing modules, designed to have the same external shape, can be allocated to various functions. 10 figs.

  19. Diesel starting system monitor: Prototype development

    The US Department of Energy (DOE) effort to extend the operational lives of commercial nuclear power plants is examining methods for predicting the performance of specific equipment. This paper focuses on predictive monitoring as a means for reducing equipment surveillance, maintenance, and outages. Realizing these goals will result in nuclear plants that are more reliable, have lower maintenance costs, and have longer lives. This report describes a prognostic monitoring system that has been developed to predict starting performance in emergency diesels. A prototype system has been built and tested on an engine at Sandia National Laboratories. 6 refs., 8 figs

  20. MR imaging of central nervous system development

    This paper reports on the first in vitro MR imaging study of human developmental anatomy. Formalin-preserved embryos and fetuses of gestational ages ranging from 8 to 38 weeks were studied with MR imaging to determine normal anatomy, with emphasis on the central nervous system. In vivo MR imaging of neonates and infants up to 18 months of age was also obtained to demonstrate the normal pattern of maturation and myelination of the brain. The normal development of the brain is shown, with some additional highlights of the spinal cord, gastrointestinal and genitourinary tracts, cardiovascular structures, and respiratory system

  1. Reframing Humans in Information Systems Development

    Isomaki, Hannakaisa

    2011-01-01

    Modern society has been transformed by the digital convergence towards a future where technologies embed themselves into the fabric of everyday life. This ongoing merging of social and technological infrastructures provides and necessitates new possibilities to renovate past notions, models and methods of information systems development that accommodates humans as actors within the infrastructure. This shift introduces new possibilities for information systems designers to fulfil more and more everyday functions, and to enhance their value and worth to the user. "Reframing Humans in Infor

  2. Development and Implementation of Sepsis Alert Systems.

    Harrison, Andrew M; Gajic, Ognjen; Pickering, Brian W; Herasevich, Vitaly

    2016-06-01

    Development and implementation of sepsis alert systems is challenging, particularly outside the monitored intensive care unit (ICU) setting. Barriers to wider use of sepsis alerts include evolving clinical definitions of sepsis, information overload, and alert fatigue, due to suboptimal alert performance. Outside the ICU, barriers include differences in health care delivery models, charting behaviors, and availability of electronic data. Current evidence does not support routine use of sepsis alert systems in clinical practice. Continuous improvement in the afferent and efferent aspects will help translate theoretic advantages into measurable patient benefit. PMID:27229639

  3. Risk management in information system development

    Ristola, Teemu

    2011-01-01

    The purpose of this study is to facilitate the implementation process of the case corporation’s new information system for managing their inventory of bus tires. This study attempts to answer the questions “What were the main IT-risks in-volved with the development and implementation of the new bus tire inventory management system, what kind of effects did they have and how were they dealt with”. The study was carried out with the cooperation of the case corporation, Koiviston Auto, as a part...

  4. Development of PET systems and their applications

    Positron emission tomography (PET) is widely used in clinical field as non-invasive imaging technique, especially tumor detection using a radio tracer, fluorodeoxyglucose (FDG). While the clinical use of PET is rapidly expanding, there is a growing interest in more advanced functions such as in vivo imaging of gene expression and protein product. According to the demand for improving system performance, many efforts in PET instrumentation have been directed toward higher spatial resolution without scarifying the effective sensitivity. Various PET detectors and systems developed by Hamamatsu are introduced in this paper. (author)

  5. Development of A Plant Navigation System

    A 'Plant Navigation System (PNS)' is under development to assist nuclear power plant (NPP) operators by automatically displaying the plant situation and plant operational procedures on a CRT screen when abnormalities occur. The operation procedures given in a symptom-oriented manual are expressed in a tree - type flowchart (modified PAD). The optimum operation procedure for an NPP is selected automatically using built-in diagnostic logics based on the current status of the NPP. Concerning the plant situation, the PNS displays important information only on the current status of the NPP. A prototype PNS system is being constructed. (authors)

  6. Space Launch System Accelerated Booster Development Cycle

    Arockiam, Nicole; Whittecar, William; Edwards, Stephen

    2012-01-01

    With the retirement of the Space Shuttle, NASA is seeking to reinvigorate the national space program and recapture the public s interest in human space exploration by developing missions to the Moon, near-earth asteroids, Lagrange points, Mars, and beyond. The would-be successor to the Space Shuttle, NASA s Constellation Program, planned to take humans back to the Moon by 2020, but due to budgetary constraints was cancelled in 2010 in search of a more "affordable, sustainable, and realistic" concept2. Following a number of studies, the much anticipated Space Launch System (SLS) was unveiled in September of 2011. The SLS core architecture consists of a cryogenic first stage with five Space Shuttle Main Engines (SSMEs), and a cryogenic second stage using a new J-2X engine3. The baseline configuration employs two 5-segment solid rocket boosters to achieve a 70 metric ton payload capability, but a new, more capable booster system will be required to attain the goal of 130 metric tons to orbit. To this end, NASA s Marshall Space Flight Center recently released a NASA Research Announcement (NRA) entitled "Space Launch System (SLS) Advanced Booster Engineering Demonstration and/or Risk Reduction." The increased emphasis on affordability is evident in the language used in the NRA, which is focused on risk reduction "leading to an affordable Advanced Booster that meets the evolved capabilities of SLS" and "enabling competition" to "enhance SLS affordability. The purpose of the work presented in this paper is to perform an independent assessment of the elements that make up an affordable and realistic path forward for the SLS booster system, utilizing advanced design methods and technology evaluation techniques. The goal is to identify elements that will enable a more sustainable development program by exploring the trade space of heavy lift booster systems and focusing on affordability, operability, and reliability at the system and subsystem levels5. For this study, affordability is defined as lifecycle cost, which includes design, development, test, and engineering (DDT&E), production and operational costs (P&O). For this study, the system objectives include reducing DDT&E schedule by a factor of three, showing 99.9% reliability, flying up to four times per year, serving both crew and cargo missions, and evolving to a lift capability of 130 metric tons.3 After identifying gaps in the current system s capabilities, this study seeks to identify non-traditional and innovative technologies and processes that may improve performance in these areas and assess their impacts on booster system development. The DDT&E phase may be improved by incorporating incremental development testing and integrated demonstrations to mitigate risk. To further reduce DDT&E, this study will also consider how aspects of the booster system may have commonality with other users, such as the Department of Defense, commercial applications, or international partners; by sharing some of the risk and investment, the overall development cost may be reduced. Consideration is not limited to solid and liquid rocket boosters. A set of functional performance characteristics, such as engine thrust, specific impulse (Isp), mixture ratio, and throttle range are identified and their impacts on the system are evaluated. This study also identifies how such characteristics affect overall life cycle cost, including DDT&E and fixed and variable P&O.

  7. Development of severe accident training support system

    In order for appropriate decision-making during plant operation and management, the professional knowledge, expert's opinion, and previous experiences as well as information for current status are utilized. The operation support systems such as training simulators have been developed to assist these decision-making process, and most of them cover from normal operation to emergency operation because of the very low frequency of severe accident and of uncertaintics included in severe accident phenomena and scenarios. However, the architectures for severe accident management are being established based on severe accident management guidelines in some developed countries. Recentrly, in Korea, as teh severe accident management guideline was developed, the basis for establishing severe accident management architecture is prepared and this leads to the development of tool for systematic education and training for personnel related to severe accident management. The severe accident taining support system thus is developed to assist decision-making during execution of severe accident management guidelines by providing plant status information, prefessional knowledge for phenomena and scenarios, expected behavior for strategy execution, and so on

  8. Development of Door Sill Assembly Test System

    Nordlund, Mikko

    2013-01-01

    This study was done to a product development unit of a Finnish elevator technology company and it was focused on one of the components of the whole elevator, the door sill assembly. The study had two goals, the main goal was to introduce and to further develop a test system created for testing door sill assemblies, and the secondary goal was to create a technical documentation about the door sill assembly for training purpose. The main issue with the sill assembly is that one of the main...

  9. Development of HIDEC adaptive engine control systems

    Landy, R. J.; Yonke, W. A.; Stewart, J. F.

    1986-01-01

    The purpose of NASA's Highly Integrated Digital Electronic Control (HIDEC) flight research program is the development of integrated flight propulsion control modes, and the evaluation of their benefits aboard an F-15 test aircraft. HIDEC program phases are discussed, with attention to the Adaptive Engine Control System (ADECS I); this involves the upgrading of PW1128 engines for operation at higher engine pressure ratios and the production of greater thrust. ADECS II will involve the development of a constant thrust mode which will significantly reduce turbine operating temperatures.

  10. Development of in-situ monitoring system

    Development of in-situ monitoring system using an optical fiber to measure the real time temperature variation of subsurface water for the evaluation of flow characteristics. We describe the feasibility of developing a fiber-optic temperature sensor using a thermochromic material. A sensor-tip is fabricated by mixing of a thermochromic material powder. The relationships between the temperatures and the output voltages of detectors are determined to measure the temperature of water. It is expected that the fiber-optic temperature monitoring sensor using thermochromic material can be used to measure the real time temperature variation of subsurface water

  11. Towards a Provotyping Approach in Systems Development

    Mogensen, Preben Holst

    1992-01-01

    concrete experience is developed through an investigation of prototyping and activity theory. Exploration of this notion leads to the idea of the systemdeveloper ‘provoking ’ concrete, everyday practice, by exposing current problems, calling forth what usually is taken for granted. Problems with current...... practice and a lack of mutual understanding, usually conceived of as hindrances to successful systems development, are used constructively. These ideas are compared to four related approaches: Future Workshops, Metaphorical Design, Cooperative Prototyping, and Organizational Games. The comparison serves...

  12. Development of design window evaluation and display system. 1. System development and performance confirmation

    Purpose: The work was performed to develop a design window evaluation and display system for the purpose of obtaining the effects of various design parameters on the typical thermal hydraulic issues resulting from a use of various kind of working fluid etc. easily. Method: The function of the system were 'confirmation of design margin' of the present design, 'confirmation of the affected design zone' when a designer changed some design parameter, and search for an design improvement' for design optimization. The system was developed using existing soft wares on PC and the database relating analytical results of typical thermal hydraulic issues provided by separate work. Results: (1) System design: In order to develop a design window evaluation and display system, 'numerical analysis unit', 'statistical analysis unit', 'MMI unit', 'optimization unit' were designed based on the result of selected optimization procedure and display visualization. Further, total system design was performed combining these units. Typical thermal hydraulic issues to be considered are upper plenum thermal hydraulics, thermal stratification, free surface sloshing, flow-induced vibration of a heat exchanger and thermal striping in the T-junction piping systems. (2) Development of prototype system and a functional check: A prototype system of a design window evaluation and display system was developed and the functions were confirmed as was planned. (author)

  13. A Guerilla Approach to Control System Development

    Dovc, J; Plesko, M

    2001-01-01

    We present our experiences in managing the development cycles of the control systems for ANKA and the ALMA Common Software. Our team consists practically only of undergraduate students. Stimulating and rewarding the students with cutting-edge technologies and travel to conferences like this and installation fieldwork are an important positive factor in raising their motivation. However, building any system with a group of inexperienced students is quite a challenging task. Many problems occur with planning deadlines and missing them, organizing and managing development, sources, and documentation and also when dealing with conventional program management rules. To cope with them, we use many tools: CVS for versioning and source archiving, Bugzilla for keeping our bugs in order, a to-do list for managing tasks, an activity log and also many other programs and scripts, some found on the Internet and some made by ourselves. In the end, we had to become organized like a professional company. Documentation and dem...

  14. Remote maintenance system development for ITER blankets

    In ITER, the in-vessel components such as blanket are to be maintained or replaced remotely since they will be activated by 14 MeV neutrons. For this, the remote handling equipment for blanket maintenance is required to handle a heavy payload of about 4 tonne within a positioning accuracy of 2 mm. According to the ITER R and D program, a rail-mounted vehicle manipulator system was developed and remote replacement of blanket module has been successfully demonstrated using the fabricated full-scale vehicle manipulator system. In addition, the bore tools moving inside the blanket cooling pipes were also developed, and remote welding, cutting and inspection operations for the blanket maintenance have been verified. (author)

  15. Legacy Information System Development: Problems and Issues

    Muheet Ahmed Butt

    2012-12-01

    Full Text Available The Information Communication Technology has improved the quality of services being provided by organizations beyond proportions. Another most distinguishing characteristic of ICT is the storage, retrieval, processing as well as the communication of Data. However development of Information System is always associated with many problems and issues. In fact resistance to change is a universally acknowledged fact but since the influence of ICT is felt at all levels therefore automation mostly meets multifold problems. It is because of this fact that despite distinct superiority of ICT still it is implemented in phased manner. Similarly the available technology also limits the working of the Information System. Other issues related with the development of the information are the developmental, operational besides security.

  16. Development of technical information processing system (VII)

    The goal of this project is to establish integrated environment focused on enhanced information services to researchers through the providing of acquisition information, key phrase retrieval function, journal content information linked with various subsystems already developed. The results of the project are as follows. 1. It is possible to serve information on unreceivable materials among required materials throughout the system. 2. Retrieval efficiency is increased by the adding of key phrase retrieval function. 3. Rapidity of information service is enhanced by the providing of journal contents of each issue received and work performance of contents service is become higher. 4. It is possible to acquire, store, serve technical information needed in R and D synthetically and systematically throughout the development of total system linked with various subsystems required to technical information management and service. 21 refs. (Author)

  17. Development of NMCA system and software

    Full text: Development of the NMCA system in the Institute of Atomic Energy is described. The Institute is the one of research scientific subdivisions of the National Nuclear Center of the Republic of Kazakhstan. Four nuclear facilities in the country is operating. Institute is a facility with two research reactors, located on the remote sites of the former Semipalatinsk nuclear test site. Layouts and main parameters of the reactors are attached. In additional to reactors, NM storages, on-pile stands, research labs and hot cell are located on sites. The NM storing and handling are covered by NMCA system which after USSR disintegration was in a bad condition: on-paper account, lack of personal training, normative documents, measuring system, and access control. After ratification of Safeguards Agreement all Kazakhstan's nuclear facilities became to being inspected by IAEA and State authority. Putting of the NMCA system according to international rules is started. Since 1993 a collaboration with Departments of Defense and Energy is begun, particularly with Los-Alamos, Sandia and Oak-Ridge National labs. Directions of development and needs of technical and methodical assistance were defined. In the following time a computers for account, spectrometric and weighing equipment for NDA, TID and other office equipment were delivered. Development of a number of documents concerning regulation of NM handling, IAEA inspectors cooperation, reporting was conducted under ORNL support. NMCA custodians were participants of many training courses held in Kazakhstan, NIS, LANL, NRC. The computerized NMCA system 'AIMAS' developed in ANL and delivered to the Institute was implemented successfully in 1995. During some followed years the 'AIMAS' system was modified step by step and spread to other nuclear facilities of Kazakhstan and Uzbekistan under DOE support. The important element of supporting of SSAC development in Kazakhstan is funding and providing with methodic of annual workshops-conferences for NMCA custodians from Kazakhstan and Uzbekistan. These meetings are conducted continuously on the all nuclear facilities so that the NMCA specialists have a chance to meet their progress in NMCA area. Last such meeting was conducted in August 2005 at the Institute of Atomic Energy. (author)

  18. Development of a digital videogrammetric airborne system

    Peralta-Fabi, Ricardo; Peralta, Alejandro; Prado, Jorge M.; Navarrete, Margarita; Martinez, W.

    1993-10-01

    A system to conduct airborne remote sensing campaigns by means of CCD cameras and associated navigation and positioning equipment is presented. The system is under further development at the University of Mexico, but has been tested in several missions to evaluate its functional characteristics. The paper describes the various components of the system, such as cameras, aircraft mounting, pointing subsystem, GPS, location of view axis, real time monitoring and enhancement of ground details, as well as spectral filters and bands utilized, the interaction between obtained images, attitude data and a geographic information system for mosaic reconstruction, pilot navigation aids, and test polygons. The operation of the system has been demonstrated to be highly economical, reliable and relatively simple to use. It can also be fitted to various types of aircraft and helicopters, and may be used to conduct many types of missions such as: crop discrimination and mapping, urban settlement studies, land use charts, soil erosion evaluation, forest health, urban thermal island characterization, plant disease studies, and many more. A description of the flow of information from image capture to paper map is included, together with the methodology necessary to derive, from the images obtained, a multimedia system that handles a georeferenced data base for consultation by personnel of diverse backgrounds.

  19. Development of 100Ci tritium handling system

    A new experimental system has been developed for use of pure tritium amounting to 100 Ci at a time. The system consists of two experimental chambers and other components such as tritium storage-supply, gas purification, isotope separation, and exhaust gas handling devices. These components provide a complete tritium circulation in the system, and hence tritium waste can be minimized for a variety of experimental works. One of the chambers is designed for experiments using molecular tritium, and the other hand tritium plasma generated with ECR discharge. A Zr-Ni alloy is applied for impurity removal from the exhaust gas from both of the experimental chambers and gas chromatography is used for the isotope separation of purified hydrogen isotope mixtures. Other kinds of gettering materials are used for tritium isotope-supply. The exhaust gas handling system has two different devices; one is a conventional wet device, consisting of a Pt-catalyst bed and a molecular sieve bed, the other a dry device using two getter beds. This paper describes the details of the system as well as its components and the results of system performance test using non-radioactive hydrogen isotopes. (author)

  20. Development of integrated analytical data management system

    The Analysis Subsection of Technical Service Section, Tokai Reprocessing Plant, Tokai Works, is engaged in analysis activities required for the management of processes and measurements in the plant. Currently, it has been desired to increase the reliability of analytical data and to perform analyses more rapidly to cope with the increasing number of analysis works. To meet this end, on-line data processing has been promoted and advanced analytical equipment has been introduced in order to enhance automization. In the present study, an integrated analytical data mangement system is developed which serves for improvement of reliability of analytical data as well as for rapid retrieval and automatic compilation of these data. Fabrication of a basic model of the system has been nearly completed and test operation has already been started. In selecting hardware to be used, examinations were made on easiness of system extension, Japanese language processing function for improving man-machine interface, large-capacity auxiliary memory system, and data base processing function. The existing analysis works wer reviewed in establishing the basic design of the system. According to this basic design, the system can perform such works as analysis of application slips received from clients as well as recording, sending, filing and retrieval of analysis results. (Nogami, K.)

  1. INTEGRATED HSEQ MANAGEMENT SYSTEMS: DEVELOPMENTS AND TRENDS

    Osmo Kauppila

    2015-06-01

    Full Text Available The integration of health and safety, environmental and quality (HSEQ management systems has become a current topic in the 21st century, as the need for systems thinking has grown along with the number of management system standards. This study aims to map current developments and trends in integrated HSEQ management. Three viewpoints are taken: the current state of the main HSEQ management standards, research literature on integrated management systems (IMS, and a case study of an industry-led HSEQ cluster in Northern Finland. The results demonstrate that some of the most prominent current trends are the harmonization of the high level structure of management systems by ISO, the evaluation of IMS, accounting for the supply chain in HSEQ issues, and sustainability and risk management. The results of the study can be used by practitioners to get a view of the current state of HSEQ management systems and their integration, and by researchers to seek out potential directions for HSEQ and IMS related research.

  2. Herding agent field application system development

    Buist, Ian; Belore, Randy [SL Ross Environmental Research (Canada)], email: ian@slross.com

    2011-07-01

    Chemical herding agents can be applied to deal with an oil slick. This study investigates the key system components of application systems for herding agents and shows how application systems can also be developed for operational herder usage in drift ice. These two application systems are respectively required for small boat and a helicopter operations. The factors, including the selection of flow rates, pressures and atomizing nozzle types, which give the appropriate herder droplet size distributions for small boat and aerial application systems were investigated in the initial stage of the study. In a later stage, on commercializing herders for in situ burning, further research is expected to deal with the many problems not tackled in the initial stage, such as the mounting of the nozzles, pumps and reservoirs on various aerial platforms and the provision of heating and insulation for cold-weather use. The paper presented the experiments and simulations that have been conducted as well as the basic design parameters for field application systems.

  3. DFM – Weldability analysis and system development

    Pabolu, Venkata Krishna Rao

    2015-01-01

    This thesis work is mainly focused on the processes involved in manufacturing of aircraft engine components. The processes are especially about welding and welding methods. The basics of welding and the thesis support has been taken from the GKN Aerospace Sweden AB, a global aerospace product supplier.  The basic objective of this thesis work is to improve the usability of an automation system which is developed for evaluating the weldability of a part. A long run maintainability aspect of th...

  4. Antenna development for wearable wireless sensing systems

    O'Flynn, Brendan; Gaetano, Domenico; Buckley, John

    2009-01-01

    Embedded wireless sensor network (WSN) systems have been developed and used in a wide variety of applications such as local automatic environmental monitoring; medical applications analysing aspects of fitness and health energy metering and management in the built environment as well as traffic pattern analysis and control applications. While the purpose and functions of embedded wireless sensor networks have a myriad of applications and possibilities in the future, a particular i...

  5. Development of an aircraft design expert system

    Alsina, J.

    1988-01-01

    The aircraft design process is characterised by the application of a wide range of knowledge across many disciplines based upon a certain degree of judgement and experience of the designer. A two pass approach has been taken towards the development of an aircraft design expert system based on the requirements of two conceptually different design steps namely, wing design and aircraft configuration. The current status of the work is one where an actual program for wing des...

  6. StreamingBandit: Developing Adaptive Persuasive Systems

    Kaptein, Maurits; Kruijswijk, Jules

    2016-01-01

    This paper introduces StreamingBandit, a (back-end) solution for developing adaptive and personalized persuasive systems. Creating successful persuasive applications requires a combination of design, social science, and technology. StreamingBandit contributes to the required technology by providing a platform that can be used to adapt persuasive technologies in real-time and at large scales. We first introduce the design philosophy of StreamingBandit using a running example and highlight how ...

  7. Development of an automated handwriting analysis system

    Vikram Kamath; Nikhil Ramaswamy; P. Navin Karanth; Vijay Desai; S. M. Kulkarni

    2011-01-01

    In the present study a method has been proposed for the behavioral prediction of a person through automated handwriting analysis. The present work identifies the psychological traits in the writing namely size, slant and pressure, baseline, number of breaks, margins, speed of writing and spacing between the words. The handwriting is analyzed through Image Processing in MATLAB. The behavioral pattern of the person is predicted from the above traits of the handwriting. The developed system iden...

  8. Development of JT-60 database management system

    The JT-60 experimental database management system (DBMS) has been developed in the front end processor (FEP) at the JAERI computer center. The JT-60 DBMS provides creation of the database, its user interfaces of data handling and graphic processing, and support tools of database management for physical and engineering analyses. This paper is concerned with the requirements for the DBMS and its design consideration

  9. Systems Medicine in Pharmaceutical Research and Development.

    Kuepfer, Lars; Schuppert, Andreas

    2016-01-01

    The development of new drug therapies requires substantial and ever increasing investments from the pharmaceutical company. Ten years ago, the average time from early target identification and optimization until initial market authorization of a new drug compound took more than 10 years and involved costs in the order of one billion US dollars. Recent studies indicate even a significant growth of costs in the meanwhile, mainly driven by the increasing complexity of diseases addressed by pharmaceutical research.Modeling and simulation are proven approaches to handle highly complex systems; hence, systems medicine is expected to control the spiral of complexity of diseases and increasing costs. Today, the main focus of systems medicine applications in industry is on mechanistic modeling. Biological mechanisms are represented by explicit equations enabling insight into the cooperation of all relevant mechanisms. Mechanistic modeling is widely accepted in pharmacokinetics, but prediction from cell behavior to patients is rarely possible due to lacks in our understanding of the controlling mechanisms. Data-driven modeling aims to compensate these lacks by the use of advanced statistical and machine learning methods. Future progress in pharmaceutical research and development will require integrated hybrid modeling technologies allowing realization of the benefits of both mechanistic and data-driven modeling. In this chapter, we sketch typical industrial application areas for both modeling techniques and derive the requirements for future technology development. PMID:26677181

  10. Health care system reform in developing countries

    Wei Han

    2012-10-01

    Full Text Available This article proposes a critical but non-systematic review of recent health care system reforms in developing countries. The literature reports mixed results as to whether reforms improve the financial protection of the poor or not. We discuss the reasons for these differences by comparing three representative countries: Mexico, Vietnam, and China. First, the design of the health care system reform, as well as the summary of its evaluation, is briefly described for each country. Then, the discussion is developed along two lines: policy design and evaluation methodology. The review suggests that i background differences, such as social development, poverty level, and population health should be considered when taking other countries as a model; ii although demand-side reforms can be improved, more attention should be paid to supply-side reforms; and iii the findings of empirical evaluation might be biased due to the evaluation design, the choice of outcome, data quality, and evaluation methodology, which should be borne in mind when designing health care system reforms.

  11. Radiation risks to the developing nervous system

    A symposium dealing with 'Radiation Risks to the Developing Nervous System' held at Neuherberg, June 18-20, 1985 was organised by the Radiation Protection Programme of the Commission of the European Communities and the Gesellschaft fuer Strahlen- und Umweltforschung mbH. The proceedings of this symposium present up-to-date information on the development of the nervous system and the modifications caused by prenatal radiation there upon. A large part of the proceedings is devoted to the consequences of prenatal irradiation in experimental animals with respect to alterations in morphology, biochemistry and behaviour, to the influence of dose, dose rate and radiation quality and to the question whether damage of the brain can arise from a synergistic action of radiation together with other agents. Since animal models for damage to the human central nervous system have inherent short-comings due to the differences in structure, complexity and development it is discussed how experimental studies could be applied to the human situation. The most recent data on persons exposed in utero at Hiroshima and Nagasaki are reviewed. A round table discussion, published in full, analyses all this information with a view to radiation protection, and defines the areas where future studies are needed. Separate abstracts were prepared for papers in these proceedings. (orig./MG)

  12. LSD (Landing System Development) Impact Simulation

    Ullio, R.; Riva, N.; Pellegrino, P.; Deloo, P.

    2012-07-01

    In the frame of the Exploration Programs, a soft landing on the planet surface is foreseen. To ensure a successful final landing phase, a landing system by using leg tripod design landing legs with adequate crushable damping system was selected, capable of absorbing the residual velocities (vertical, horizontal and angular) at touch- down, insuring stability. TAS-I developed a numerical non linear dynamic methodology for the landing impact simulation of the Lander system by using a commercial explicit finite element analysis code (i.e. Altair RADIOSS). In this paper the most significant FE modeling approaches and results of the analytical simulation of landing impact are reported, especially with respect to the definition of leg dimensioning loads and the design update of selected parts (if necessary).

  13. Development of an automated handwriting analysis system

    Vikram Kamath

    2011-09-01

    Full Text Available In the present study a method has been proposed for the behavioral prediction of a person through automated handwriting analysis. The present work identifies the psychological traits in the writing namely size, slant and pressure, baseline, number of breaks, margins, speed of writing and spacing between the words. The handwriting is analyzed through Image Processing in MATLAB. The behavioral pattern of the person is predicted from the above traits of the handwriting. The developed system identifies handwriting closely which may not be possible for a graphologist. It is real time and involves less image preprocessing. The proposed system is calibrated with manual analysis. The results obtained through the system are in good agreement to more than 80 percent of the cases with ideal manual analysis.

  14. Development of Sic Gas Sensor Systems

    Hunter, G. W.; Neudeck, P. G.; Okojie, R. S.; Beheim, G. M.; Thomas, V.; Chen, L.; Lukco, D.; Liu, C. C.; Ward, B.; Makel, D.

    2002-01-01

    Silicon carbide (SiC) based gas sensors have significant potential to address the gas sensing needs of aerospace applications such as emission monitoring, fuel leak detection, and fire detection. However, in order to reach that potential, a range of technical challenges must be overcome. These challenges go beyond the development of the basic sensor itself and include the need for viable enabling technologies to make a complete gas sensor system: electrical contacts, packaging, and transfer of information from the sensor to the outside world. This paper reviews the status at NASA Glenn Research Center of SiC Schottky diode gas sensor development as well as that of enabling technologies supporting SiC gas sensor system implementation. A vision of a complete high temperature microfabricated SiC gas sensor system is proposed. In the long-term, it is believed that improvements in the SiC semiconductor material itself could have a dramatic effect on the performance of SiC gas sensor systems.

  15. System Transfer, Education, and Development in Mozambique

    Jose Cossa

    2011-03-01

    Full Text Available In this study the author used conceptual historical method to assess the phenomenon of system transfer and the association between education and development in Mozambique. The assessment was administered through critical analysis of documents pertaining to the Salazar (1924-1966, Machel (1975-1986, and Chissano (1986-2005 administrations. The findings were that (a the colonial government created economic and educational systems for colonizing Mozambique, whereas the Machel and Chissano administrations adapted foreign systems of government and education (i.e., Socialism, Soviet, Democracy, Portuguese, etc., to their particular context without altering the inherent theoretical basis of the systems transferred; (b the Machel and Chissano administrations, implicitly or explicitly, perceived the relationship between education and development as circular causality rather than a unidirectional linear causality, while the Salazar administration perceived it as unidirectional linear causality; and (c while the Machel and Chissano administrations focused on primary education, literacy campaigns, and education of women and girls, they differed in the reasons for such focus.

  16. Solar Energy Forecast System Development and Implementation

    Jascourt, S. D.; Kirk-Davidoff, D. B.; Cassidy, C.

    2012-12-01

    Forecast systems for predicting real-time solar energy generation are being developed along similar lines to those of more established wind forecast systems, but the challenges and constraints are different. Clouds and aerosols play a large role, and for tilted photovoltaic panels and solar concentrating plants, the direct beam irradiance, which typically has much larger forecast errors than global horizontal irradiance, must be utilized. At MDA Information Systems, we are developing a forecast system based on first principles, with the well-validated REST2 clear sky model (Gueymard, 2008) at its backbone. In tuning the model and addressing aerosol scattering and surface albedo, etc., we relied upon the wealth of public data sources including AERONET (aerosol optical depth at different wavelengths), Suominet (GPS integrated water vapor), NREL MIDC solar monitoring stations, SURFRAD (includes upwelling shortwave), and MODIS (albedo in different wavelength bands), among others. The forecast itself utilizes a blend of NWP model output, which must be brought down to finer time resolution based on the diurnal cycle rather than simple interpolation. Many models currently do not output the direct beam irradiance, and one that does appears to have a bias relative to its global horizontal irradiance, with equally good performance attained by utilizing REST2 and the model global radiation to estimate the direct component. We will present a detailed assessment of various NWP solar energy products, evaluating forecast skill at a range of photovoltaic installations.

  17. Development of decommissioning engineering support system for fugen. Development of support system during actual dismantlement works

    The Advanced Thermal Reactor, Fugen Nuclear Power Station was permanently shut down in March 2003, and is now preparing for decommissioning. We have been developing Decommissioning Engineering Support System (DEXUS) aimed at planning optimal dismantlement process and carrying out dismantlement work safely and precisely. DEXUS consists of 'decommissioning planning support system' and 'dismantling support system'. The dismantling support system is developed aiming at using during actual dismantling work. It consists of three subsystems such as 'Worksite Visualization System', 'Dismantling Data Collection System' and 'Generated Waste Management System'. 'Worksite Visualization System' is a support system designed to provide the necessary information to workers during actual dismantlement works. And this system adopts AR (Augmented Reality) technology, overlapping calculation information into real world. 'Dismantling Data Collection System' is to collect necessary data for improving accuracy of decommissioning planning by evaluating work content and worker equipage, work time for dismantlement works. 'Generated Waste Management system' is a system recording necessary information by attaching the barcode to dismantled wastes or the containers. We can get the information of generated waste by recording generation place, generated time, treatment method and the contents. These subsystems enable to carry out reasonable and safe decommissioning of Fugen. In addition, we expect that those systems will be used for decommissioning of other nuclear facilities in the future. (authors)

  18. Advanced Gas Turbine Powertrain System Development Project

    Helms, H. E.

    1980-01-01

    A progress report on the Advanced Gas Turbine Powertrain System Development Project being performed under contract from NASA Lewis is presented. The goals and objectives of the project are described noting that funds from the DOE, Office of Transportation Programs are used to sponsor the project. Among the demonstration objectives are attaining a fuel economy of 42.5 miles per gallon in a 1985 Pontiac Phoenix, multifuel capability, and emission levels within the federal standards. Design objectives examined include competitive reliability and life as well as competitive initial and life cycle costs. Finally, it is stressed that high risk and key elements in this advanced powertrain project are the development of ceramic turbine engine components and the aerodynamic development of small size turbine components.

  19. Development of an intellectual maintenance management system. Development of trouble detection and troubleshooting evaluation system

    Many research activities are conducted to enhance cost performance and safety of nuclear power plants operation and maintenance. Concept of autonomous operating system to equal the role of operators and of maintenance personnel with artificial intelligence and autonomous robots has been developed. An intellectual maintenance management system has been developed to be equipped with decision making functions of maintenance personnel. The intellectual maintenance management system is in charge of maintenance function of an autonomous plant, which consists of plant-wide monitoring, evaluation of component integrity, and scheduling of maintenance activities. In other words, this system should be equipped with preventive maintenance and corrective maintenance functions those are currently loaded on personnel. In this report, we discussed condition monitoring maintenance in the preventive maintenance. We also reported a sensor validation system development for machinery condition monitoring and diagnosis. We adopted distributed and cooperative system construction technique, which is expected recently in applications to large-scale plants. This system has inter-agent communication function for signal transmission and reception among distributed physics models of machineries. The system has been constructed for water/steam system of the LMFBR power plant. The system has been validated to be capable of cooperative sensor validation by the distributed set of agents, with quantitative indication of sensor deviation based on a newly developed fuzzy algorithm with inter-agent cooperation. The derived reference parameter value from the inter-agent evaluations also stands for the alternative measurement to the malfunctioned sensor. (author)

  20. Development of the Medium Energy Linac Systems

    The main purposes of the proton engineering frontier project is developing a proton linac which accelerates 20 mA proton beams up to 100 MeV and supplying 20 MeV and 100 MeV proton beams to the user groups. The project 'Development of the medium energy linac systems' is aiming to design the 100 MeV proton linac, to construct an accelerating cavity, to design a MEBT system, and to develop a energy measurement system. The 100 MeV linac consists of 20 DTL tanks which are operated by five additional klystrons. The focusing lattice is FFDD as the 20 MeV DTL. However the hollow conductors are used for coils of the quadrupole magnets. The shape of the drift tubes in the new tanks is changed to compensate the reduction of the accelerating efficiency in the high energy region. For example, the face angle of drift tubes begins at 40 degrees. The bore radius is selected as 10 mm in order to eliminate beam loss in the beam line. We can obtain the 100 MeV proton beams by using these accelerating structure. We have designed some of the tanks in detail. It covers the modification of the structure by including the stem, post-coupler, and sulg-tuner effects, the error analysis, the thermal and structure analysis, the drift tube design, the magnet design, the various ports design, the support structure design, the end-plate design, etc. Now the first DTL tank is constructed by a local company. An beam extraction system is essential after 20 MeV DTL in order to supply 20 MeV proton beams. Since there are no focusing elements in the structure, the beam should be spread out. The MEBT which consists of two 3-cell DTL tanks is designed to control the beam size in the beam extraction system by magnets in the first tank and to transversely match the beam into the next DTL by magnets in the the second tank. The longitudinal matching is done by the RF in both tanks. We have also developed an energy measurement system using the time of flight method

  1. Development of Vertical Cable Seismic System (2)

    Asakawa, E.; Murakami, F.; Tsukahara, H.; Ishikawa, K.

    2012-12-01

    The vertical cable seismic is one of the reflection seismic methods. It uses hydrophone arrays vertically moored from the seafloor to record acoustic waves generated by surface, deep-towed or ocean bottom sources. Analyzing the reflections from the sub-seabed, we could look into the subsurface structure. This type of survey is generally called VCS (Vertical Cable Seismic). Because VCS is an efficient high-resolution 3D seismic survey method for a spatially-bounded area, we proposed the method for the hydrothermal deposit survey tool development program that the Ministry of Education, Culture, Sports, Science and Technology (MEXT) started in 2009. We are now developing a VCS system, including not only data acquisition hardware but data processing and analysis technique. Our first experiment of VCS surveys has been carried out in Lake Biwa, JAPAN in November 2009 for a feasibility study. Prestack depth migration is applied to the 3D VCS data to obtain a high quality 3D depth volume. Based on the results from the feasibility study, we have developed two autonomous recording VCS systems. After we carried out a trial experiment in the actual ocean at a water depth of about 400m and we carried out the second VCS survey at Iheya Knoll with a deep-towed source. In this survey, we could establish the procedures for the deployment/recovery of the system and could examine the locations and the fluctuations of the vertical cables at a water depth of around 1000m. The acquired VCS data clearly shows the reflections from the sub-seafloor. Through the experiment, we could confirm that our VCS system works well even in the severe circumstances around the locations of seafloor hydrothermal deposits. We have carried out two field surveys in 2011. One is a 3D survey with a boomer for a high-resolution surface source and the other one for an actual field survey in the Izena Cauldron an active hydrothermal area in the Okinawa Trough. Through these surveys, we have confirmed that the uncertainty in the locations of the source and of the hydrophones in water could lower the quality of subsurface image. It is, therefore, strongly necessary to develop a total survey system that assures an accurate positioning and a deployment techniques. In case of shooting on sea surface, GPS navigation system are available, but in case of deep-towed source or ocean bottom source, the accuracy of shot position with SSBL/USBL is not sufficient for the very high-resolution imaging as requested for the SMS survey. We will incorporate the accurate LBL navigation systems with VCs. The LBL navigation system has been developed by IIS of the University of Tokyo. The error is estimated less than 10cm at the water depth of 3000m. Another approach is that the shot points can be calculated using the first break of the VCS after the VCS locations are estimated by slant-ranging from the sea surface. Our VCS system has been designed as a survey tool for hydrothermal deposit, but it will be also applicable for deep water site surveys or geohazard assessment such as active faults.

  2. Development of superconducting ship propulsion system

    When we plan displacement-type monohull high speed vessels, it is difficult to get the hull form with the wave-making resistance minimum, because the stern shape is restricted by arrangement of propulsive machines and shafts. A small-sized and light-weight propulsive machines will reduce the limit to full form design. Superconducting technology will have capability of realizing the small-sized and light-weight propulsion motor. The superconducting electric propulsion system which is composed of superconducting propulsion motors and generators, seems to be an ideal propulsion system for future vehicles. We have constructed a 480 kW superconducting DC homopolar laboratory test motor for developing this propulsion system. The characteristic of this motor is that it has a superconducting field winding and a segmented armature drum. The superconducting field winding which operates in the persistent current mode, is cooled by a condensation heat exchanger and helium refigerating system built into the cryostat of the superconducting field winding. The operating parameters of this motor agreed well with the design parameters. Using the design concepts of this motor, we have conceptually designed a 150,000-200,000 PS superconducting electric propulsive system for a displacement-type monohull high speed ship. (author)

  3. Development of cost-benefit analysis system

    In order to promote the FDR development, it is necessary to see various benefits brought by introduction of FBR from multiple perspectives and have a good grasp of such benefits quantitatively and an adequate R and D investment scale which corresponds with them. In this study, the structured prototype in the previous study was improved to be able to perform cost-benefit analysis. An example of improvement made in the system is addition of subroutine used for comparison between new energy and benefits brought by introduction of FBR with special emphasis on addition of logic for analyzing externality about the new energy. Other improvement examples are modification of the Conventional Year Expense Ratio method of power generation cost to Average Durable Year Cost method, addition of database function and turning input data into database, and reviewing idea on cost by the type of waste material and price of uranium. The cost-benefit analysis system was also restructured utilizing Microsoft ACCESS so that it should have a data base function. As the result of the improvement mentioned above, we expect that the improved cost-benefit analysis system will have higher generality than the system before; therefore, great deal of benefits brought by application of the system in the future is expected. (author)

  4. Master Console System Monitoring and Control Development

    Brooks, Russell A.

    2013-01-01

    The Master Console internship during the summer of 2013 involved the development of firing room displays and support applications at the John F. Kennedy Space Center (KSC). This position was with the Master Console Product Group (MCPG) on the Launch Control System (LCS) project. This project is responsible for the System Monitoring and Control (SMC) and Record and Retrieval (R&R) of launch operations data. The Master Console is responsible for: loading the correct software into each of the remaining consoles in the firing room, connecting the proper data paths to and from the launch vehicle and all ground support equipment, and initializing the entire firing room system to begin processing. During my internship, I created control scripts using the Application Control Language (ACL) to analyze the health and status of Kennedy Ground Control System (KGCS) programmable logic controllers (PLCs). This application provides a system health and status display I created with summarized data for use by Master Console Operators (MCO) to monitor and verify the integrity of KGCS subsystems.

  5. Lunar Surface Systems Supportability Technology Development Roadmap

    Oeftering, Richard C.; Struk, Peter M.; Green, Jennifer L.; Chau, Savio N.; Curell, Philip C.; Dempsey, Cathy A.; Patterson, Linda P.; Robbins, William; Steele, Michael A.; DAnnunzio, Anthony; Meseroll, Robert; Quiter, John; Shannon, Russell; Easton, John W.; Madaras, Eric I.; BrownTaminger, Karen M.; Tabera, John T.; Tellado, Joseph; Williams, Marth K.; Zeitlin, Nancy P.

    2011-01-01

    The Lunar Surface Systems Supportability Technology Development Roadmap is a guide for developing the technologies needed to enable the supportable, sustainable, and affordable exploration of the Moon and other destinations beyond Earth. Supportability is defined in terms of space maintenance, repair, and related logistics. This report considers the supportability lessons learned from NASA and the Department of Defense. Lunar Outpost supportability needs are summarized, and a supportability technology strategy is established to make the transition from high logistics dependence to logistics independence. This strategy will enable flight crews to act effectively to respond to problems and exploit opportunities in an environment of extreme resource scarcity and isolation. The supportability roadmap defines the general technology selection criteria. Technologies are organized into three categories: diagnostics, test, and verification; maintenance and repair; and scavenge and recycle. Furthermore, "embedded technologies" and "process technologies" are used to designate distinct technology types with different development cycles. The roadmap examines the current technology readiness level and lays out a four-phase incremental development schedule with selection decision gates. The supportability technology roadmap is intended to develop technologies with the widest possible capability and utility while minimizing the impact on crew time and training and remaining within the time and cost constraints of the program.

  6. Flammability test for sunglasses: developing a system

    Magri, Renan; Ventura, Liliane

    2014-02-01

    Recent investigations show the need for certificating sunglasses to ensure the safety and health to population. The Brazilian Standard ABNT NBR 15111 regulates features to sunglasses, however, there is not a sunglasses certification office in Brazil, therefore, our lab has been developing several equipment for sunglasses testing. This work refers to one of them: the flammability test system for sunglasses in compliance with the NBR 15111. The standard provides requirements for the flammability test procedure which requires that the equipment must operate at a temperature of 650 °C +/- 20 °C the end of a steel rod of 300 mm length and 6 mm diameter should be heated and pressed over the surface of the lenses for five seconds; the flammability is checked by visual inspection. The furnace is made of ceramic. We used a power electronic circuit to control the power in the furnace using ON/OFF mode and for measuring the temperature, we used a K-type thermocouple. A stepper motor with pulley lifts the steel rod. The system reaches the working temperature in 15 minutes for a step input of 61 V in open loop system. The electronics control are under development in order to shorten the time necessary to reach the working temperature and maintain the temperature variation in the furnace within the limits imposed by the standard as next steps.

  7. New developments of the GANIL control system

    Since the first ion beam, the GANIL accelerator has been driven by a Control System built around a minicomputer MITRA 125 and a distributed intelligence consisting of Programmable Controllers and INTEL 8080-equipped autonomous CAMAC Controllers. CAMAC is the digital transmission standard adopted to interface the processors to the GANIL facilities. In order to cope with the growing needs of the accelerator operation, many developments of the Control System have been carried out during the last years or are underway. After a brief description of the GANIL Control System, this paper describes the major improvements undertaken in four main directions: a) Upgrading the Control Computer. The minicomputer MITRA 125 will be replaced by a faster one equipped with much larger memories and disk capabilities. b) Introducing more powerful local intelligence. An autonomous CAMAC Controller called DIVA 68C using the 68000 microprocessor has been developed. Also, the 68000 will be used in a general purpose CAMAC module, the first application of which is to replace the existing data link modules. c) Improving the human-machine interface with the use of color graphic terminals. d) Meeting the requirements for the coming second injector. For this purpose, a fully equipped auxiliary console is being installed near the main console for operation by summer 1985. (orig.)

  8. Development of decommissioning system engineering technology

    In the decommissioning planning stage, it is important to select the optimized decommissioning process considering the cost and safety. Especially the selection of the optimized decommissioning process is necessary because it affects to improve worker's safety and decommissioning work efficiency. The decommissioning process evaluation technology can provide the optimized decommissioning process as constructing various decommissioning scenarios and it can help to prevent the potential accidents as delivering the exact work procedures to workers and to help workers to perform decommissioning work skillfully. It's necessary to measure the radioactive contamination in the highly contaminated facilities such as hot-cells or glove-boxes to be decommissioned for decommissioning planning. These facilities are very high radiation level, so it is difficult to approach. In this case the detector system is preferable to separate the sensor and electronics, which have to locate in the facility outside to avoid the electric noise and worker's radiation exposure. In this project, we developed the remote detection system for radiation measurement and signal transmission in the high radiation area. In order to minimize worker's exposure when decommissioning highly activated nuclear facilities, it is necessary to develop the remote handling tool to perform the dismantling work remotely. Especially, since cutting, measuring, and decontamination works should be performed remotely in the highly activated area, the remote handling tool for conducting these works should be developed. Therefore, the multi-purpose dismantling machine that can measuring dose, facility cutting, and remote handling for maintenance and decommissioning of highly activated facility should be needed

  9. Development of the plutonium oxide vitrification system

    Repository disposal of plutonium in a suitable, immobilized form is being considered as one option for the disposition of surplus weapons-usable plutonium. Accelerated development efforts were completed in 1997 on two potential immobilization forms to facilitate downselection to one form for continued development. The two forms studied were a crystalline ceramic based on Synroc technology and a lanthanide borosilicate (LaBS) glass. As part of the glass development program, melter design activities and component testing were completed to demonstrate the feasibility of using glass as an immobilization medium. A prototypical melter was designed and built in 1997. The melter vessel and drain tube were constructed of a Pt/Rh alloy. Separate induction systems were used to heat the vessel and drain tube. A Pt/Rh stirrer was incorporated into the design to facilitate homogenization of the melt. Integrated powder feeding and off-gas systems completed the overall design. Concurrent with the design efforts, testing was conducted using a plutonium surrogate LaBS composition in an existing (near-scale) melter to demonstrate the feasibility of processing the LaBS glass on a production scale. Additionally, the drain tube configuration was successfully tested using a plutonium surrogate LaBS glass

  10. Advanced systems: Status and development prospects

    World reserves of coal, uranium, thorium and thermonuclear fuel (deuterium and lithium) are sufficient to provide mankind with energy for many centuries. The rate of increase in demand is unlikely to be a limiting factor, and it would seem that any ''limits to growth'' will be dictated by other, in particular ecological, factors. In the last two decades, world power production has developed a structure in which a predominant place is occupied by oil and gas; this will have to change as a result of the marked depletion of oil resources and the enhanced role played in the fuel balance by power from coal and nuclear fission, on which, it would seem, the long-term growth of world energy production will be based. The contribution of nuclear fission power towards meeting world energy needs will depend on a number of factors, the most important of which from a long-term point of view is the time and rate of introduction of advanced nuclear power systems and fuel cycles with high nuclear fuel surpluses (breeding ratios). The results of almost 30 years of development of nuclear power with thermal-neutron reactors may serve as a basis for the analysis, evaluation and forecasting of the development of advanced systems. (author)

  11. Development of the Open Items Tracking System

    The West Valley Demonstration Project, located on the site of the only commercial nuclear fuel reprocessing facility to have operated in USA, has the directed objectives of solidifying the high-level radioactive waste into a durable, solid form for shipment; decontaminating and decommissioning the tanks and facilities; and disposing of the resulting low-level and transuranic wastes. Since an escalating trend of open work items was noticed in the Fall of 1988, and there was no control mechanism for tracking and closing the open items, a Work Control System was developed for this purpose. It is self-contained system on a mainframe ARTEMIS 9000, which tracks, monitors, and closes out external commitments in a timely manner. Audits, surveillances, site appraisals, preventive maintenance, instrument calibration recall, and scheduling are covered

  12. Development of nuclear plant piping support system

    Design and construction of a nuclear power plant is characterized by its voluminous work extending for a long period on account of the increasingly stringent requirements focused on productivity to keep ''just in time'' construction schedule by paying close attention to both safety and availability of the plant. The Nuclear Plant Piping Support System has been developed in order to increase productivity with the best quality and to keep down the cost. This system selects the optimum size of structures for each support and sets this data in the central engineering data base of the main frame computer. Therefore, the data can be used for various subsystems such as design analysis, material handling and the control of production. (author)

  13. Development of industrial variant specification systems

    Hansen, Benjamin Loer

    tasks are discussed. A list of structural variables and solution components has been created. These are related to four design aspects in the holistic system design covering the aspects of process design, selection of resources (such as hardware, software and humans), the design of information...... acquisition and order fulfilment, i.e. the creation of drawings, bill-of-materials, routings, product descriptions, quote letters etc. The present thesis is rooted in the assumption that variant specification systems supporting the cross-functional processes of order acquisition and order fulfilment must be...... and the challenge of understanding the variant specification tasks and the connections between variant specification, product development, sales, manufacturing, and information technology. The present thesis seeks to meet this challenge with a procedure, concepts and tools. This is done through an...

  14. New developments of the GANIL control system

    Since its first ion beam, the GANIL accelerator has been driven by a Control System built around a minicomputer MITRA 125 and a distributed intelligence consisting of programmable Controllers and INTEL 8080 equipped autonomous CAMAC Controllers. After a brief description of the GANIL Control System, this paper will lay emphasis on the major improvements undertaken along four main directions: a) Upgrading the Control Computer. b) Introducing more powerful local intelligence. A microprocessorized autonomous CAMAC Controller called ''DIVA 68C'' using the 68000 microprocessor embedded in a VME card has been developed. Also, the 68000 will be used in a general purpose CAMAC module, the first application of which is to replace the existing data link modules. (c) Making human-machine dialog smarter with use of color graphic terminals. d) Meeting the requirements of the coming second injector. In this purpose a fully equipped auxiliary console is being installed near the main console for operation by summer 1985

  15. Development of energy and transport systems

    Economic development and the advancement of technology is presented as a process of substituting old forms of satisfying human needs by new ones or, more precisely, as a sequence of such substitutions. The examples, reconstructed from historical records, describe the quantitative, technological changes in energy and transport systems. The analysis of historical replacement of old by new technologies has shown that most of these processes can be described by simple rules that are captured in the logistic substitution model, and that technological substitution, expressed in terms of market shares, follows characteristic S-shaped curves. To illustrate the properties of the approach examples are given of how new energy forms replaced their predecessors. To further explore the method similar substitution processes in transport systems are described. 21 refs, 23 figs, 1 tab

  16. NANOTECHNOLOGY IN DEVELOPMENT OF DRUG DELIVERY SYSTEM

    Vidyavathi Maravajhala et al.

    2012-01-01

    Full Text Available Nanotechnology is science of matter and material that deal with particle size in nanometers. Nanotechnology has received a lot of attention with never-seen-before enthusiasm because of its future potential. It has provided fine lined diagnosis and focus treatment of disease at molecular level. This technology offers the advantage of protecting drugs from degradation; reduce the number of doses required. In this review, a discussion was carried out on different techniques for the preparation of nanodrug delivery systems like nanoparticles, solid lipid nanoparticles, nanocrystals, nanosuspensions, nanoemulsions. The concept of nanotechnology is widely expanded and applied to many drugs to the present. The ultimate application goal of nano drug delivery system is to develop clinically useful formulation for treating diseases in patients.

  17. Developing Information System on Lunar Crescent Observations

    T. Hidayat

    2010-03-01

    Full Text Available We present a progress report on the development of information system of lunar crescent astronomical observations which will be largely accessible for public domain. This consists of calculations of the Moon’s ephemeris as well as systematic real-time lunar crescent observations. A well suited small telescope, equipped with a simple digital detector, is connected to a server to provide information on lunar crescent observations. The system has been used and worked well. The only constraint is poor weather condition. Network of small telescopes, installed at various locations in Indonesia, are currently planned to provide plethora of data. In the long term, this will be used to help to determine the astronomical visibility criteria of lunar crescent for Islamic calendar.

  18. Development of a tunable IR lidar system

    Amoruso, S.; Amodeo, A.; Armenante, M.; Boselli, A.; Mona, L.; Pandolfi, M.; Pappalardo, G.; Velotta, R.; Spinelli, N.; Wang, X.

    2002-05-01

    A differential absorption lidar system (DIAL) based on a continuously tunable optical parametric amplifier (OPA) pumped by a Nd : YAG laser (200 mJ at ?=355 nm) operating at a maximum pulse repetition rate of 100 Hz has been developed. The system provides continuously tunable coherent radiation in the Visible-near IR range (0.4-2.5 ?m), allowing to perform DIAL measurements in a spectral region where most of atmospheric constituents and pollutants display absorption lines. The spectral width of the OPA system is line-narrowed by using a master oscillator dye laser as seeder, achieving a linewidth of 0.04 cm -1 (FWHM), a spectral purity larger than 99% and a frequency stability better than 1 pm h -1, with an output energy in the IR of 1-10 mJ. The OPA system was used to perform DIAL measurements in the lower troposphere. Preliminary results in terms of water vapor content and aerosol backscattering profiles are presented and discussed.

  19. Development of the High Energy Linac Systems

    The main purpose of this project is studying the extension plan of the proton engineering frontier project (PEFP) 100-MeV Linac. It includes three categories. One is studying operation plan of the PEFP linac and its extended accelerators, and developing a distribution system of 100-MeV proton beams with a laser striping. Other is designing superconducting RF (SRF) modules and fabricating and testing a copper cavity model. The other is designing a rapid cycling synchrotron (RCS). The operation scheme of the PEFP linac is related to the optimization in the operation of the 100-MeV linac, 200-MeV SRF, and RCS. We studied several operational method to increase the validity of the accelerators. The beam distribution system has two roles. One is supplying proton beams of 100 MeV to the user group. The laser stripping of the negative hydrogen atoms is used in this case. The other beams are directed to the next high energy accelerators. This study contributes to increase the availability of the proton beams. The SRF is one of candidates to extend the PEFP linac system. Since the accelerating gradient of the SRF is much higher than the normal conducting accelerator, a lot of institutes over the world are developing the SRF structure. Main purposes are designing an SRF module, fabricating and testing an copper model which has similar material properties as Nb of the usual SRF cavity material. The RCS is a synchrotron whose injector is the PEFP 100-MeV linac. Main purposes are determining the lattice structure, studying the fast and slow extraction system, simulating beam behavior in the designed synchrotron. The RCS will be used as the spallation neutron source and tools in the basic and applied science including medical application

  20. Wireless Power Transfer system : Development and Implementation

    Khayrudinov, Vladislav

    2015-01-01

    The goal of the project was to develop a Wireless Power Transfer (WPT) System and implement it in innovative flooring. The project was done at NextFloor Oy, a company based in Helsinki, Finland. At the moment, Wireless Power Transmission is in the forefront of electronics research, which is why this study started as an initial attempt to investigate WPT in order to keep up with the fast growing industry. The main steps of the project were to study the physics behind wireless electricity t...

  1. Development of a THz spectroscopic imaging system

    We have developed a real-time THz imaging system based on the two-dimensional (2D) electro-optic (EO) sampling technique. Employing the 2D EO-sampling technique, we can obtain THz images using a CCD camera at a video rate of up to 30 frames per second. A spatial resolution of 1.4 mm was achieved. This resolution was reasonably close to the theoretical limit determined by diffraction. We observed not only static objects but also moving ones. To acquire spectroscopic information, time-domain images were collected. By processing these images on a computer, we can obtain spectroscopic images. Spectroscopy for silicon wafers was demonstrated

  2. EU Developments of the ITER ECRH System

    The electron cyclotron (EC) heating and current drive (H (and) CD) system of ITER will deliver 20 MW/CW in the plasma at 170 GHz for H (and) CD in addition to 2.5 MW/3 s at 120 GHz for plasma start-up. The EC system is composed of power supplies (PS), up to 24 H (and) CD gyrotrons (1 to 2 MW tubes), 3 start-up gyrotrons (1 MW tubes), 24 transmission lines and two sets of launching antennas: equatorial (EL) and upper (UL) launchers. Under the present ITER procurement package the EU is responsible for one third of the H (and) CD 170 GHz gyrotrons, all PSs associated with the H (and) CD system, and the whole set (4) of upper launchers. In all areas of participation, the EU EC partnership (coordinated by the European Fusion Development Association - EFDA) aims toward advancing the technology of each of these subsystems. For example, procurement of Pulse Step Modulator (PSM) HVPS is under consideration, which might have equivalent costs to the present ITER design (thyristor HVPS and HV series switch), but with an increased flexibility in operation and variation in the EC power waveform. The EU is at the forefront in gyrotron research and is developing a 2 MW CW 170 GHz coaxial cavity gyrotron offering an increase in output power while maintaining moderate power densities in the gyrotron cavity and collector. THALESR in collaboration with its EFDA partners (FZK, CRPP, TEKES) is manufacturing a series of prototype tubes in three phases of typically 1 s, 100 s and then CW pulse capacity (∼ 2010). A 2 MW, CW gyrotron test facility is being built at CRPP that will be used to develop the 2 MW coaxial tube, in addition to testing various components required by the EC system. EFDA has undertaken a parallel development of two launcher options: front (FS) and remote (RS) steering, with the aim of providing an optimum launcher for ITER weighing EC physics aspects and operation reliability. The FS launcher (ITER reference design) offers a significant enhancement in physics performance, while the RS (backup solution) offers a remote steering mirror far from the plasma for simplified ex-vessel maintenance access. The principle role of the UL is to stabilise neoclassical tearing modes. However, an enhanced performance UL launcher is under investigation by EFDA, seeking synergy between the EL and UL that would extend the physics potential of both launchers for an enhanced ITER EC physics performance, while at the same time relax some of the engineering requirements. (author)

  3. Development techniques of computerized maintenance Management system

    Normal operation of the facility is one of the key factors in the accomplishments of research goals. As confirmed by a case study of the influence of the facility operation condition on the research results, emphasis should be put on the facility preserve management. Facilities should be maintained in solid operational condition and their malfunctions should be repaired as soon as possible. The purpose of this project is to make propositions on the development of the facility preserve management system which is to maximize the efficiency of the budget execution, manpower organization and maintenance planning, and is to minimize the duration of the operational pause due to malfunctions with the least disbursement

  4. Development of a smart multilead thermocouple system

    Smart sensors are sensors that have independent self-diagnosis, communication, and computation abilities. Such features are highly desirable in the nuclear and other industries for economical and safety concerns. These features have become possible since fast, miniature, and inexpensive microprocessors became widely available. A smart temperature measurement system (STMS) using a multilead thermocouple (MTC) has been developed and tested at the nuclear engineering department, the University of Tennessee at Knoxville. The basic concept of the design is that an MTC, which consists of several wires joined at a single junction, has the potential to provide redundant temperature measurements with a single standard-size sensor

  5. Recent development of plasma optical systems (invited)

    Goncharov, A. A., E-mail: gonchar@iop.kiev.ua [Institute of Physics, National Academy of Science, Kiev 03028 (Ukraine)

    2016-02-15

    The article devotes a brief description of the recent development and current status of an ongoing research of plasma optical systems based on the fundamental plasma optical idea magnetic electron isolation, equipotentialization magnetic field lines, and the axi-symmetric cylindrical electrostatic plasma lens (PL) configuration. The experimental, theoretical, and simulation investigations have been carried out over recent years collaboratively between IP NASU (Kiev), LBNL (Berkeley, USA), and HCEI RAS (Tomsk). The crossed electric and magnetic fields inherent the PL configuration that provides the attractive method for establishing a stable plasma discharge at low pressure. Using PL configuration, several high reliability plasma devices were developed. These devices are attractive for many high-tech applications.

  6. A proposed architecture for ambulatory systems development.

    Buffone, G J; Petermann, C A; Bobroff, R B; Moore, D M; Dargahi, R; Moreau, D R; Gilson, H S; Li, Y; Fowler, J; Beck, J R

    1995-01-01

    We have developed an architecture and application framework known as the Ambulatory Services Architecture (ASA) for computerized management of patient records for ambulatory care. Our primary design goals included the development of an architecture that will be readily adaptable to advances in technology needed to enhance computerized patient record systems (e.g., multimedia, human-computer interfaces such as voice-to-text, and a fully distributed objects, etc.) and a data model and database implementation capable of providing the flexibility and extensibility needed to support a broad spectrum of specialty medical practices. This report describes the data model, access control, and the client/server components of the Ambulatory Services Architecture. PMID:8591199

  7. Polymer Energy Rechargeable System (PERS) Development Program

    Baldwin, Richard S.; Manzo, Michelle A.; Dalton, Penni J.; Marsh, Richard A.; Surampudi, Rao

    2001-01-01

    The National Aeronautics and Space Administration (NASA) and the Air Force Research Laboratory (AFRL) have recently established a collaborative effort to support the development of polymer-based, lithium-based cell chemistries and battery technologies to address the next generation of aerospace applications and mission needs. The overall objective of this development program, which is referred to as PERS, Polymer Energy Rechargeable System, is to establish a world-class technology capability and U.S. leadership in polymer-based battery technology for aerospace applications. Programmatically, the PERS initiative will exploit both interagency collaborations to address common technology and engineering issues and the active participation of academia and private industry. The initial program phases will focus on R&D activities to address the critical technical issues and challenges at the cell level.

  8. Recent development of plasma optical systems (invited)

    Goncharov, A. A.

    2016-02-01

    The article devotes a brief description of the recent development and current status of an ongoing research of plasma optical systems based on the fundamental plasma optical idea magnetic electron isolation, equipotentialization magnetic field lines, and the axi-symmetric cylindrical electrostatic plasma lens (PL) configuration. The experimental, theoretical, and simulation investigations have been carried out over recent years collaboratively between IP NASU (Kiev), LBNL (Berkeley, USA), and HCEI RAS (Tomsk). The crossed electric and magnetic fields inherent the PL configuration that provides the attractive method for establishing a stable plasma discharge at low pressure. Using PL configuration, several high reliability plasma devices were developed. These devices are attractive for many high-tech applications.

  9. Development of an automated ultrasonic testing system

    Shuxiang, Jiao; Wong, Brian Stephen

    2005-04-01

    Non-Destructive Testing is necessary in areas where defects in structures emerge over time due to wear and tear and structural integrity is necessary to maintain its usability. However, manual testing results in many limitations: high training cost, long training procedure, and worse, the inconsistent test results. A prime objective of this project is to develop an automatic Non-Destructive testing system for a shaft of the wheel axle of a railway carriage. Various methods, such as the neural network, pattern recognition methods and knowledge-based system are used for the artificial intelligence problem. In this paper, a statistical pattern recognition approach, Classification Tree is applied. Before feature selection, a thorough study on the ultrasonic signals produced was carried out. Based on the analysis of the ultrasonic signals, three signal processing methods were developed to enhance the ultrasonic signals: Cross-Correlation, Zero-Phase filter and Averaging. The target of this step is to reduce the noise and make the signal character more distinguishable. Four features: 1. The Auto Regressive Model Coefficients. 2. Standard Deviation. 3. Pearson Correlation 4. Dispersion Uniformity Degree are selected. And then a Classification Tree is created and applied to recognize the peak positions and amplitudes. Searching local maximum is carried out before feature computing. This procedure reduces much computation time in the real-time testing. Based on this algorithm, a software package called SOFRA was developed to recognize the peaks, calibrate automatically and test a simulated shaft automatically. The automatic calibration procedure and the automatic shaft testing procedure are developed.

  10. Progress in coating development for fusion systems

    Development of effective and reliable coatings is a key to the viability of most, if not all, fusion blanket systems. The specific purpose and requirements of the coatings vary widely, depending on the blanket concept. The efforts on coating development to date have focused primarily on electrically insulating coatings for the self-cooled lithium concepts with a vanadium alloy structure, and the tritium barrier coatings for the water-cooled, Pb-Li (WCLL) breeder concepts with ferritic steel structures. Although other coating materials are under consideration, most of the effort on the electrically insulating coatings has focused on CaO and AlN coatings on V-4Cr-4Ti alloy structure. Most of the effort on the tritium barrier coating development is focused on Al2O3 coatings formed on aluminized ferritic steels. This paper presents an overview of the status of coating development for the various fusion concepts with emphasis on the materials interaction and chemistry control issues associated with the formation, stability and performance of the coatings

  11. Development of NRU reflector wall inspection system

    In 2009 May, the National Research Universal (NRU) calandria leaked. During the next year, the calandria was inspected with six new Non-Destructive Evaluation (NDE) techniques to determine the extent of the corrosion, repaired, and finally the repair was inspected with four additional new NDE techniques before the reactor was returned to service. The calandria is surrounded by a light-water reflector vessel fabricated from the same material as the calandria vessel. Concerns that the same corrosion mechanism had damaged the reflector vessel led to the development of a system to inspect the full circumference of the reflector wall for corrosion damage. The inspection region could only be accessed through 64 mm diameter ports, was 10 m below the port, and had to be inspected from the corroded surface. The ultrasonic technique was designed to produce a closely spaced wall thickness (WT) grid over an area of approximately 5 m2 on the corroded surface using a very small probe holder. This paper describes the Reflector Wall Inspection (RWI) development project and the system that resulted. (author)

  12. Development of NRU reflector wall inspection system

    Lumsden, R.H.; Luloff, B.V.; Zahn, N.; Simpson, N., E-mail: lumsdenr@aecl.ca [Atomic Energy of Canada Limited, Chalk River, Ontario (Canada)

    2013-06-15

    In 2009 May, the National Research Universal (NRU) calandria leaked. During the next year, the calandria was inspected with six new Non-Destructive Evaluation (NDE) techniques to determine the extent of the corrosion, repaired, and finally the repair was inspected with four additional new NDE techniques before the reactor was returned to service. The calandria is surrounded by a light-water reflector vessel fabricated from the same material as the calandria vessel. Concerns that the same corrosion mechanism had damaged the reflector vessel led to the development of a system to inspect the full circumference of the reflector wall for corrosion damage. The inspection region could only be accessed through 64 mm diameter ports, was 10 m below the port, and had to be inspected from the corroded surface. The ultrasonic technique was designed to produce a closely spaced wall thickness (WT) grid over an area of approximately 5 m2 on the corroded surface using a very small probe holder. This paper describes the Reflector Wall Inspection (RWI) development project and the system that resulted. (author)

  13. Development of a versatile digital readout system

    During the research and design phase of new detector electronics, development of a suitable test environment takes a significant amount of time. Most existing systems are specifically designed for certain frontend electronics and cannot be reused for future developments. Thus, our approach is to build a flexible test environment with state-of-the-art hardware, which can be reconfigured to support various frontend electronics. This is achieved by deploying a modular design concept, which is followed in both hardware and software. Key features of the hardware platform are the gigabit optical connection to the PC, the powerful FPGA (Virtex 4), and consequent separation of analog and digital parts of the readout. Via firmware updates, arbitrary communication protocols can be implemented and the external connectors of the readout board can be freely configured. This is accompanied by a modular software framework written in C++ which declares different communication layers for easy hardware access as well as a generic storage structure for simple data handling. These levels of abstraction make it easy to add support for changed or completely new devices. The implementation of the digital readout system as well as its modular firmware and software design is presented and its key features are explained in detail.

  14. Development for 972MHz LLRF system

    The large electric power (972MHz, 3MW, Pulse width: 600-700μsec, duty: 50Hz) RF is outputted to the ACS cave used by The J-PARC linear accelerator by the klystron. The klystron driver amplifier of the developed LLRF system serves as the output 40W, and a pulse reply is 25nsec. The high frequency phase control can carry out variable in resolution of 0.1 degree or less, and the phase stability of less than ±1 degree. As a protection feature of equipment, RF is intercepted by the electric power anomaly detection of a progressive wave and a reflected wave, electric discharge detection, and VSWR anomaly detection. About VSWR anomaly detection, FPGA is adopted as VSWR arithmetic processing and RF is intercepted in less than 1 microsec. It receives unusually [the electric power of a progressive wave and a reflected wave], and can intercept RF in 300nsec with a high-speed comparator. To electric discharge, a high-speed arc sensor can be developed by high sensitivity, and RF can be intercepted in about 1 microsec. As for the whole LLRF system, sequence control is performed by the PLC unit. This paper reports the design work, the manufacture and a power measurement. (author)

  15. Active Thermal Control System Development for Exploration

    Westheimer, David

    2007-01-01

    All space vehicles or habitats require thermal management to maintain a safe and operational environment for both crew and hardware. Active Thermal Control Systems (ATCS) perform the functions of acquiring heat from both crew and hardware within a vehicle, transporting that heat throughout the vehicle, and finally rejecting that energy into space. Almost all of the energy used in a space vehicle eventually turns into heat, which must be rejected in order to maintain an energy balance and temperature control of the vehicle. For crewed vehicles, Active Thermal Control Systems are pumped fluid loops that are made up of components designed to perform these functions. NASA has been actively developing technologies that will enable future missions or will provide significant improvements over the state of the art technologies. These technologies have are targeted for application on the Crew Exploration Vehicle (CEV), or Orion, and a Lunar Surface Access Module (LSAM). The technologies that have been selected and are currently under development include: fluids that enable single loop ATCS architectures, a gravity insensitive vapor compression cycle heat pump, a sublimator with reduced sensitivity to feedwater contamination, an evaporative heat sink that can operate in multiple ambient pressure environments, a compact spray evaporator, and lightweight radiators that take advantage of carbon composites and advanced optical coatings.

  16. Development of CANDU Spent Fuel Sipping System

    As the tendency is toward radioactivity zero-leakage on the reactor core for the safe operation of nuclear power plants, the importance of detecting radioactivity leaking from fuel assemblies irradiated in the core is being on the rise. Nuclear fuel, even though it is designed and fabricated in terms of excellent thermal performance and mechanical integrity, can be damaged under unexpected circumstances. An excessive hydriding on fuel rods and pellet-to-clad interaction., etc. can result in failed fuel rod. It is, thus, considered that a inspection process is prerequisite procedure to identify causes of such failed fuel rods for the safe operation of nuclear power plants. If a fuel rod failure occurs during the operation of a nuclear power plant, the coolant water becomes contaminated by leaked fission products, and the power level of the plant has to be lowered or the operation to be stopped. In addition, the spent fuel that have been stored in a spent fuel storage pool for a long time is now transferring to a dry storage. To maximize the integrity of the dry storage, all the fuels transferring to a dry storage should be examined their integrities exactly and efficiently. Therefore, the ultimate purpose of this study is to develop a system capable of judging whether the long-term stored fuel in spent fuel storage pool is failed or not. In this study, a spent fuel sipping system with wet leakage detection technology is developed to make it possible

  17. Development of tritium cleanup system for LHD

    Energy is vital for humans and we have been consuming a large amount of fossil fuel especially from the beginning of the industrial revolution. Nowadays its huge consumption has however come to threaten our life and we have to prepare nonfossil fuels, for instance solar energy, biomass energy, nuclear energy and so on. Fusion energy is an unlimited resource and one of the strongest candidates of the future energy source. At the National Institute for Fusion Science (referred to as 'NIFS' hereafter), we have constructed a new fusion experimental device called large helical device (referred to as 'LHD' hereafter) in 1998. The device will generate a small amount of tritium, as a fusion product. In order to remove it from the exhaust gas, we have designed a tritium cleanup system based on a new concept. This system is mainly composed of a palladium permeater, a decomposer and hydrogen absorbing alloys. It may perfectly recover the tritium from exhaust gas without oxidizing it. This system is applicable for the future needs at fusion power plants. In order to remove tritium discharged from fusion experimental facilities, it is usual to employ a system by which tritiated constituents, in various chemical forms, are entirely converted to a form of water vapor by catalytic oxidation. The water vapor containing tritiated form is then absorbed by molecular sieve (referred to as 'wet system' hereafter). However, in the case of LHD, it is not rational to deliberately convert the discharged tritium into the water vapor, because the tritium discharged from LHD is almost in a form of hydrogen molecules. Moreover, the tritium in the form of water vapor affects the human body 18000 times stronger than that of hydrogen molecules. In accordance with these view points, we have developed another type of tritium cleanup system based on a new concept, in which hydrogen molecules including tritiated ones (HT, DT and T2) found in the exhaust gas of LHD are directly fixed to hydrogen absorbing alloys. Other impurities such as methane and water vapor, parts of which are tritiated, will be decomposed into each elemental form by the decomposition process and hydrogen molecules, including tritiated constituents from the decomposition (referred to as 'dry system' hereafter)

  18. System Analysis in Developing an Effective Government Internal Audit System

    Maliki Heru Santosa

    2016-01-01

    Full Text Available Units of Government Internal Audit (GIA play a significant role in developing a system of good governance. They contribute to the improvement of public services delivery and the welfare of society. But some current governance issues in Indonesia, such as corruption, accountability and performance problems, raise questions concerning the effectiveness of Indonesia’s GIA units. The complexity of these issues requires cybernetic study to find holistic and effective solutions. The objective of this study is to examine the effectiveness of government internal audit systems in order to enhance the professionalism of government internal auditors and the maturity of the management processes that they audit.  This research was based on qualitative approaches with systems methodology. The instruments used during the research were regulatory analysis, survey, and in-depth interviews. The survey involved 205 Chief Audit Executives (CAE of Government Internal Supervisory Apparatus (GISA in national government and regional governments, and was conducted on-line or on paper. The survey was complemented by in-depth interview with 24 (twenty four senior stakeholders representing practitioners (the CAE of GISA units, internal users (governors, mayors, heads of regional planning agencies, external users (Indonesia’s Supreme Audit Board, SAB, regulators, and associations of professional internal auditors, both private sector (IIA and public sector (AAIPI. The research found that the effort of enhancing the role of the GIA units should be seen holistically. The improvement of the role of GIA units related to the stakeholders, including management line of the organization, the SAB, professional associations, regulators, and law enforcement officials as well as other factors. The arrangement of the internal audit system could allow the government auditors to improve their professionalism and help line management to mature their management processes. The emerging strategic issues needed to build an effective internal audit system are the improvement of independence and objectivity of the auditors, a relationship with relevant stakeholders regulation and harmonization of regulation for the internal audit system.

  19. Development of the environmental data management system

    The recent society requires business activities with environmental consideration to every enterprise. Also, Japanese laws require those activities. For example, 'Law Concerning the Promotion of Business Activities with Environmental Consideration by Specified Corporations, etc, by Facilitating Access to Environmental Information, and Other Measures' (Environmental Consideration Law) mandates publication of a report relating to the activities of environmental consideration to each enterprise above designated size. 'Act on the Rational Use of Energy' mandates the report of the results of energy consumption and the long-term plan of the rational use of energy. Moreover, 'Act on Promotion of Global Warming Countermeasures' mandates the report of the greenhouse gas emissions. In addition to those, 'Water Pollution Control Law', 'Waste Management and Public Cleaning Law' and other environmental laws as well as environmental ordinances require business activities with environmental consideration to all companies. So, it is very important for Japan Atomic Energy Agency (JAEA) to report business activities with environmental consideration in order to build up trustful relations with the nation and communities. The Environmental Data Management System has been developed as the data base of business activities with environmental consideration in JAEA and as the means to promote the activities at every site and office of JAEA. This report summarizes the structure of the Environmental Data Management System, kinds of environmental performance data treated by the system, and gathering methods of the data. (author)

  20. Development of CANDU core monitoring system

    The research was performed to develop a CANDU Core Monitoring System(CCMS) that enables operators to have efficient core management by monitoring core power distribution, burnup distribution, and the other important core variables and managing the past core history for Wolsong Nuclear Power Plant(NPP) No. 1. CCMS uses RFSP(Reactor Fueling Simulation Program) for continuous core calculation by integrating the algorithm and assumptions validated and uses the information taken from DCC(Digital Control Computer) for the purpose of producing basic input data. CCMS could be largely divided into two modules; CCMS server program and CCMS client program. CCMS server program plays the role in automatic and continuous RFSP run and management of the past output data resulting from the run using Data Base Management System(DBMS). CCMS client program enables users to monitor current and past core status with GUI(Graphic-User Interface) environment predefined. The effectiveness of CCMS was verified by comparing the data resulted from field-test of the system for about 43 hours with the data used in the field of Wolsong NPP No. 1

  1. Web-based Core Design System Development

    The selection of a loading pattern is one of core design processes in the operation of a nuclear power plant. A potential new loading pattern is identified by selecting fuels that to not exceed the major limiting factors of the design and that satisfy the core design conditions for employing fuel data from the existing loading pattern of the current operating cycle. The selection of a loading pattern is also related to the cycle plan of an operating nuclear power plant and must meet safety and economic requirements. In selecting an appropriate loading pattern, all aspects, such as input creation, code runs and result processes are processed as text forms manually by a designer, all of which may be subject to human error, such as syntax or running errors. Time-consuming results analysis and decision-making processes are the most significant inefficiencies to avoid. A web-based nuclear plant core design system was developed here to remedy the shortcomings of an existing core design system. The proposed system adopts the general methodology of OPR1000 (Korea Standard Nuclear Power Plants) and Westinghouse-type plants. Additionally, it offers a GUI (Graphic User Interface)-based core design environment with a user-friendly interface for operators. It reduces human errors related to design model creation, computation, final reload core model selection, final output confirmation, and result data validation and verification. Most significantly, it reduces the core design time by more than 75% compared to its predecessor

  2. Developments of a Targeted Ensemble Prediction System

    Hersbach, H.; Mureau, R.; Opsteegh, J. D.; Barkmeijer, J.

    2003-04-01

    Based on results presented in a previous paper, an Ensemble Prediction System, especially designed for the short-range to early-medium range for the European domain (TEPS), was further developed. Between 1 January 1999 and 27 February 2000 this system was run for two cases per week. Results were compared to the ensemble prediction system (EPS) that was operational at the European Centre for Medium-Range Weather Forecasts at the time. The focus was on weather parameters. Several configurations were tested. Besides perturbations that optimize total error growth for the European domain at 48 h, perturbations relevant for shorter forecast times were included as well. Firstly, in accordance with EPS, evolved northern hemispheric singular vectors (ETEPS) and secondly, targeted singular vectors with an optimization time of 12 h (STEPS) were added. Compared to EPS, ensemble spread was increased in the short range, having a beneficial effect on statistical properties such as reliability and the frequency of outliers. Spread-skill correlations improved as well. Best performance was found for the STEPS configuration. The impact on Brier scores, relative operating characteristic curves and cost-loss analyses was less clear. From the singular vector point of view, the positive impact of using targeted perturbations is evident. However, after integration (STEPS or ETEPS), it was difficult to find synoptic cases in which this clear impact is still present.

  3. Development of multichannel MEG system at IGCAR

    Mariyappa, N.; Parasakthi, C.; Gireesan, K.; Sengottuvel, S.; Patel, Rajesh; Janawadkar, M. P.; Radhakrishnan, T. S.; Sundar, C. S.

    2013-02-01

    We describe some of the challenging aspects in the indigenous development of the whole head multichannel magnetoencephalography (MEG) system at IGCAR, Kalpakkam. These are: i) fabrication and testing of a helmet shaped sensor array holder of a polymeric material experimentally tested to be compatible with liquid helium temperatures, ii) the design and fabrication of the PCB adapter modules, keeping in mind the inter-track cross talk considerations between the electrical leads used to provide connections from SQUID at liquid helium temperature (4.2K) to the electronics at room temperature (300K) and iii) use of high resistance manganin wires for the 86 channels (868 leads) essential to reduce the total heat leak which, however, inevitably causes an attenuation of the SQUID output signal due to voltage drop in the leads. We have presently populated 22 of the 86 channels, which include 6 reference channels to reject the common mode noise. The whole head MEG system to cover all the lobes of the brain will be progressively assembled when other three PCB adapter modules, presently under fabrication, become available. The MEG system will be used for a variety of basic and clinical studies including localization of epileptic foci during pre-surgical mapping in collaboration with neurologists.

  4. Latvian natural gas system and its development

    The data presented in the paper evidence that natural gas consumption decreased from 2.91 billion m3 in 1991 to 0.95 in 1994, while in the period 1997-1999 it was levelled at about 1.3 billion m3. It is expected that there will be a gradual increase in natural gas consumption from 1.32 billion m:3 in 2001 to 1.95 billion m3 in 2005 mainly due to to development of co-generation stations and significant growth in the industrial sector. All the gas consumed in Latvia is imported from Russia during the summer period and injected into the Incukalns Underground Gas Storage for winter needs, in particular, for Latvian consumers as well as, partly, for Estonia and North-West of Russia. Latvia processes unique geological conditions for creation of a system of natural underground gas storage in the future with an active total volume of up to 50 billion m3. By integration of the Latvian underground gas storage system in the joint Russian - European gas transmission system, Latvia could become a major seasonal regulator of natural gas for Western regions of Russia and for Baltic Sea countries: Lithuania, Estonia, Finland, and Sweden. (author)

  5. Time fractional development of quantum systems

    Ertik, Hüseyin; Demirhan, Doǧan; Şirin, Hüseyin; Büyükkılıç, Fevzi

    2010-08-01

    In this study, the effect of time fractionalization on the development of quantum systems is taken under consideration by making use of fractional calculus. In this context, a Mittag-Leffler function is introduced as an important mathematical tool in the generalization of the evolution operator. In order to investigate the time fractional evolution of the quantum (nano) systems, time fractional forms of motion are obtained for a Schrödinger equation and a Heisenberg equation. As an application of the concomitant formalism, the wave functions, energy eigenvalues, and probability densities of the potential well and harmonic oscillator are time fractionally obtained via the fractional derivative order α, which is a measure of the fractality of time. In the case α =1, where time becomes homogenous and continuous, traditional physical conclusions are recovered. Since energy and time are conjugate to each other, the fractional derivative order α is relevant to time. It is understood that the fractionalization of time gives rise to energy fluctuations of the quantum (nano) systems.

  6. Time fractional development of quantum systems

    In this study, the effect of time fractionalization on the development of quantum systems is taken under consideration by making use of fractional calculus. In this context, a Mittag-Leffler function is introduced as an important mathematical tool in the generalization of the evolution operator. In order to investigate the time fractional evolution of the quantum (nano) systems, time fractional forms of motion are obtained for a Schroedinger equation and a Heisenberg equation. As an application of the concomitant formalism, the wave functions, energy eigenvalues, and probability densities of the potential well and harmonic oscillator are time fractionally obtained via the fractional derivative order α, which is a measure of the fractality of time. In the case α=1, where time becomes homogenous and continuous, traditional physical conclusions are recovered. Since energy and time are conjugate to each other, the fractional derivative order α is relevant to time. It is understood that the fractionalization of time gives rise to energy fluctuations of the quantum (nano) systems.

  7. Development of intellectual reactor design system IRDS

    An intellectual reactor design system IRDS has been developed to support feasibility study and conceptual design of new type reactors in the fields of reactor core design including neutronics, thermal-hydraulics and fuel design. IRDS is an integrated software system in which a variety of computer codes in the different fields are installed. An integration of simulation modules are performed by the information transfer between modules through design model in which the design information of the current design work is stored. An object oriented architecture is realized in frame representation of core configuration in a design data base. The knowledge relating to design tasks to be performed are encapsulated, to support the conceptual design work. The system is constructed on an engineering workstation, and supports efficiently design work through man-machine interface adopting the advanced information processing technologies. Optimization methods for design parameters with use of the artificial intelligence technique are now under study, to reduce the parametric study work. A function to search design window in which design is feasible is realized in the fuel pin design. (orig.)

  8. Power Systems Development Facility. Environmental Assessment

    1993-06-01

    The objective of the PSDF would be to provide a modular facility which would support the development of advanced, pilot-scale, coal-based power systems and hot gas clean-up components. These pilot-scale components would be designed to be large enough so that the results can be related and projected to commercial systems. The facility would use a modular approach to enhance the flexibility and capability for testing; consequently, overall capital and operating costs when compared with stand-alone facilities would be reduced by sharing resources common to different modules. The facility would identify and resolve technical barrier, as well as-provide a structure for long-term testing and performance assessment. It is also intended that the facility would evaluate the operational and performance characteristics of the advanced power systems with both bituminous and subbituminous coals. Five technology-based experimental modules are proposed for the PSDF: (1) an advanced gasifier module, (2) a fuel cell test module, (3) a PFBC module, (4) a combustion gas turbine module, and (5) a module comprised of five hot gas cleanup particulate control devices. The final module, the PCD, would capture coal-derived ash and particles from both the PFBC and advanced gasifier gas streams to provide for overall particulate emission control, as well as to protect the combustion turbine and the fuel cell.

  9. Development of a Universal Waste Management System

    Baccus, Shelley; Broyan, James L., Jr.

    2013-01-01

    A concept for a Universal Waste Management System (UWMS) has been developed based on the knowledge gained from over 50 years of space travel. It is being designed for Commercial Orbital Transportation Services (COTS) and Multi ]Purpose Crew Vehicle (MPCV) and is based upon the Extended Duration Orbiter (EDO) commode. The UMWS was modified to enhance crew interface and reduce volume and cost. The UWMS will stow waste in fecal canisters, similar to the EDO, and urine will be stowed in bags for in orbit change out. This allows the pretreated urine to be subsequently processed and recovered as drinking water. The new design combines two fans and a rotary phase separator on a common shaft to allow operation by a single motor. This change enhances packaging by reducing the volume associated with an extra motor, associated controller, harness, and supporting structure. The separator pumps urine to either a dual bag design for COTS vehicles or directly into a water reclamation system. The commode is supported by a concentric frame, enhancing its structural integrity while further reducing the volume from the previous design. The UWMS flight concept development effort is underway and an early output of the development will be a ground based UMWS prototype for manned testing. Referred to as the Gen 3 unit, this prototype will emulate the crew interface included in the UWMS and will offer a great deal of knowledge regarding the usability of the new design, allowing the design team the opportunity to modify the UWMS flight concept based on the manned testing.

  10. Development of Shimadzu digital subtraction system

    Shimadzu has recently developed a digital subtraction system. It can perform intra-arterial digital subtraction angiography (DSA) using low concentration of contrast medium, or can visualize arteries with intravenuous injection. It can extremely reduce patient's pain in angiography. Image quality of DSA has been much improved by the development of high quality image amplifiers, improvement of signal-to-noise ratio of the x-ray television unit and the development of digital disk recorders. The peak-hold subtraction method that is now under clinical study presents images of blood vessels as the trace of the flow of contrast medium. The maximum-hold memory where the maximum value of the brightness in some period is stored for every picture element is subtracted from the minimum-hold memory where the minimum value is stored, and thus images of blood vessels can be obtained. Hardware of this method is rather simple and it is expected that the amount of contrast medium may be reduced or x-ray dose of the patient may be decreased. (author)

  11. Development of novel emission tomography system

    Fu, Geng

    In recent years, small animals, such as mice and rats, have been widely used as subjects of study in biomedical research while molecular biology and imaging techniques open new opportunities to investigate disease model. With the help of medical imaging techniques, researchers can investigate underlying mechanisms inside the small animal, which are useful for both early diagnosis and treatment monitoring. Based on tracer principle single photon emission computed tomography (SPECT) has increased popularity in small animal imaging due to its higher spatial resolution and variety of single-photon emitting radionuclides. Since the image quality strongly depends on the detector properties, both scintillation and semiconductor detectors are under active investigation for high resolution X-ray and gamma ray photon detection. The desired detector properties include high intrinsic spatial resolution, high energy resolution, and high detection efficiency. In this thesis study, we have made extensive efforts to develop novel emission tomography system, and evaluate the use of both semiconductor and ultra-high resolution scintillation detectors for small animal imaging. This thesis work includes the following three areas. Firstly, we have developed a novel energy-resolved photon counting (ERPC) detector. With the benefits of high energy resolution, high spatial resolution, flexible detection area, and a wide dynamic range of 27--200keV, ERPC detector is well-suited for small animal SPECT applications. For prototype ERPC detector excellent imaging (˜350microm) and spectroscopic performance (4keV Co-57 122keV) has been demonstrated in preliminary study. Secondly, to further improve spatial resolution to hundred-micron level, an ultra-high resolution Intensified EMCCD (I-EMCCD) detector has been designed and evaluated. This detector consists of the newly developed electron multiplying CCD (EMCCD) sensor, columnar CsI(Tl) scintillator, and an electrostatic de-magnifier (DM) tube. The detector offers the combination of an excellent intrinsic spatial resolution, a good signal-to-noise ratio (SNR), a large active area, and reasonable detection efficiency over the energy range from 27 to 140 keV. Based on I-EMCCD detector we developed a prototype dual-head single photon emission microscope (SPEM) system for mouse imaging. Both phantom and animal imaging experiments have been performed to evaluate system capabilities for ultra-high resolution SPECT imaging. In addition, we have presented a feasibility study of using emission tomography system for synchrotron X-ray fluorescence computer tomography (XFCT). Based on high resolution semiconductor detector and collimation aperture, X-ray fluorescence emission tomography (XFET) can offer more imaging information content by each detected photon and allow less scanning motion, which help to overcome the hurdle for current X-ray fluorescence computed tomography (XFCT) and improve imaging speed. CCD-based emission tomography system has been set up at the Advanced Photon Source (APS) for phantom and animal imaging. It has demonstrated that XFET is capable of acquiring 3D element distribution with a greatly improved imaging speed. Key words: SPECT, ERPC, I-EMCCD, SPEM, APS, and XFET

  12. Development and Control of a Non Linear Magnetic Levitation System

    A Sanjeevi Gandhi

    2013-06-01

    Full Text Available Nowadays, studies to develop and control non linear systems is of great significance. Magnetic Levitation System has gained considerable interests due to its great practical importance in different engineering fields In this paper an electromagnetic levitation system was developed and mathematical model for the system was derived. The developed system was controlled manually.

  13. Development of Vertical Cable Seismic System (3)

    Asakawa, E.; Murakami, F.; Tsukahara, H.; Mizohata, S.; Ishikawa, K.

    2013-12-01

    The VCS (Vertical Cable Seismic) is one of the reflection seismic methods. It uses hydrophone arrays vertically moored from the seafloor to record acoustic waves generated by surface, deep-towed or ocean bottom sources. Analyzing the reflections from the sub-seabed, we could look into the subsurface structure. Because VCS is an efficient high-resolution 3D seismic survey method for a spatially-bounded area, we proposed the method for the hydrothermal deposit survey tool development program that the Ministry of Education, Culture, Sports, Science and Technology (MEXT) started in 2009. We are now developing a VCS system, including not only data acquisition hardware but data processing and analysis technique. We carried out several VCS surveys combining with surface towed source, deep towed source and ocean bottom source. The water depths of the survey are from 100m up to 2100m. The target of the survey includes not only hydrothermal deposit but oil and gas exploration. Through these experiments, our VCS data acquisition system has been completed. But the data processing techniques are still on the way. One of the most critical issues is the positioning in the water. The uncertainty in the positions of the source and of the hydrophones in water degraded the quality of subsurface image. GPS navigation system are available on sea surface, but in case of deep-towed source or ocean bottom source, the accuracy of shot position with SSBL/USBL is not sufficient for the very high-resolution imaging. We have developed another approach to determine the positions in water using the travel time data from the source to VCS hydrophones. In the data acquisition stage, we estimate the position of VCS location with slant ranging method from the sea surface. The deep-towed source or ocean bottom source is estimated by SSBL/USBL. The water velocity profile is measured by XCTD. After the data acquisition, we pick the first break times of the VCS recorded data. The estimated positions of shot points and receiver points in the field include the errors. We use these data as initial guesses, we invert iteratively shot and receiver positions to match the travel time data. After several iterations we could finally estimate the most probable positions. Integration of the constraint of VCS hydrophone positions, such as the spacing is 10m, can accelerate the convergence of the iterative inversion and improve results. The accuracy of the estimated positions from the travel time date is enough for the VCS data processing.

  14. Geographic Information Systems and Web Page Development

    Reynolds, Justin

    2004-01-01

    The Facilities Engineering and Architectural Branch is responsible for the design and maintenance of buildings, laboratories, and civil structures. In order to improve efficiency and quality, the FEAB has dedicated itself to establishing a data infrastructure based on Geographic Information Systems, GIs. The value of GIS was explained in an article dating back to 1980 entitled "Need for a Multipurpose Cadastre which stated, "There is a critical need for a better land-information system in the United States to improve land-conveyance procedures, furnish a basis for equitable taxation, and provide much-needed information for resource management and environmental planning." Scientists and engineers both point to GIS as the solution. What is GIS? According to most text books, Geographic Information Systems is a class of software that stores, manages, and analyzes mapable features on, above, or below the surface of the earth. GIS software is basically database management software to the management of spatial data and information. Simply put, Geographic Information Systems manage, analyze, chart, graph, and map spatial information. At the outset, I was given goals and expectations from my branch and from my mentor with regards to the further implementation of GIs. Those goals are as follows: (1) Continue the development of GIS for the underground structures. (2) Extract and export annotated data from AutoCAD drawing files and construct a database (to serve as a prototype for future work). (3) Examine existing underground record drawings to determine existing and non-existing underground tanks. Once this data was collected and analyzed, I set out on the task of creating a user-friendly database that could be assessed by all members of the branch. It was important that the database be built using programs that most employees already possess, ruling out most AutoCAD-based viewers. Therefore, I set out to create an Access database that translated onto the web using Internet Explorer as the foundation. After some programming, it was possible to view AutoCAD files and other GIS-related applications on Internet Explorer, while providing the user with a variety of editing commands and setting options. I was also given the task of launching a divisional website using Macromedia Flash and other web- development programs.

  15. Development of Vertical Cable Seismic System

    Asakawa, E.; Murakami, F.; Sekino, Y.; Okamoto, T.; Ishikawa, K.; Tsukahara, H.; Shimura, T.

    2011-12-01

    In 2009, Ministry of Education, Culture, Sports, Science and Technology(MEXT) started the survey system development for Hydrothermal deposit. We proposed the Vertical Cable Seismic (VCS), the reflection seismic survey with vertical cable above seabottom. VCS has the following advantages for hydrothermal deposit survey. (1) VCS is an efficient high-resolution 3D seismic survey in limited area. (2) It achieves high-resolution image because the sensors are closely located to the target. (3) It avoids the coupling problems between sensor and seabottom that cause serious damage of seismic data quality. (4) Because of autonomous recording system on sea floor, various types of marine source are applicable with VCS such as sea-surface source (GI gun etc.) , deep-towed or ocean bottom source. Our first experiment of 2D/3D VCS surveys has been carried out in Lake Biwa, JAPAN, in November 2009. The 2D VCS data processing follows the walk-away VSP, including wave field separation and depth migration. Seismic Interferometry technique is also applied. The results give much clearer image than the conventional surface seismic. Prestack depth migration is applied to 3D data to obtain good quality 3D depth volume. Seismic Interferometry technique is applied to obtain the high resolution image in the very shallow zone. Based on the feasibility study, we have developed the autonomous recording VCS system and carried out the trial experiment in actual ocean at the water depth of about 400m to establish the procedures of deployment/recovery and to examine the VC position or fluctuation at seabottom. The result shows that the VC position is estimated with sufficient accuracy and very little fluctuation is observed. Institute of Industrial Science, the University of Tokyo took the research cruise NT11-02 on JAMSTEC R/V Natsushima in February, 2011. In the cruise NT11-02, JGI carried out the second VCS survey using the autonomous VCS recording system with the deep towed source provided by Institute of Industrial Science, the University of Tokyo. It generates high frequency acoustic waves around 1kHz. The acquired VCS data clearly shows the reflections and currently being processed for imaging the subsurface structure.

  16. NASA's Space Launch System Development Status

    Lyles, Garry

    2014-01-01

    Development of the National Aeronautics and Space Administration's (NASA's) Space Launch System (SLS) heavy lift rocket is shifting from the formulation phase into the implementation phase in 2014, a little more than 3 years after formal program establishment. Current development is focused on delivering a vehicle capable of launching 70 metric tons (t) into low Earth orbit. This "Block 1" configuration will launch the Orion Multi-Purpose Crew Vehicle (MPCV) on its first autonomous flight beyond the Moon and back in December 2017, followed by its first crewed flight in 2021. SLS can evolve to a130t lift capability and serve as a baseline for numerous robotic and human missions ranging from a Mars sample return to delivering the first astronauts to explore another planet. Benefits associated with its unprecedented mass and volume include reduced trip times and simplified payload design. Every SLS element achieved significant, tangible progress over the past year. Among the Program's many accomplishments are: manufacture of core stage test barrels and domes; testing of Solid Rocket Booster development hardware including thrust vector controls and avionics; planning for RS- 25 core stage engine testing; and more than 4,000 wind tunnel runs to refine vehicle configuration, trajectory, and guidance. The Program shipped its first flight hardware - the Multi-Purpose Crew Vehicle Stage Adapter (MSA) - to the United Launch Alliance for integration with the Delta IV heavy rocket that will launch an Orion test article in 2014 from NASA's Kennedy Space Center. The Program successfully completed Preliminary Design Review in 2013 and will complete Key Decision Point C in 2014. NASA has authorized the Program to move forward to Critical Design Review, scheduled for 2015 and a December 2017 first launch. The Program's success to date is due to prudent use of proven technology, infrastructure, and workforce from the Saturn and Space Shuttle programs, a streamlined management approach, and judicious use of new technologies. The result is a safe, affordable, sustainable, and evolutionary path to development of an unprecedented capability for future missions across the solar system. In an environment of economic challenges, the nationwide SLS team continues to meet ambitious budget and schedule targets. This paper will discuss SLS Program and technical accomplishments over the past year and provide a look at the milestones and challenges ahead.

  17. A dam-break simulation using the higher-order MPS(Moving Particle Semi-implicit) Method with a new treatment of the Neumann boundary condition

    Cheng, D.; Yamada, T.

    2014-12-01

    MPS(Moving Particle Semi-implicit) Method is a Lagrangian numerical analysis method, which does not necessary to set the lattice. Thus, it is effective for the analysis with complicated boundary such as free surface flow. On the other hand, since it is possible that particles varying their relative positions in MPS method, it courses a problem of non-uniformity in the spatial distribution of particles, thereby generating pressure fluctuation. Solving the pressure fluctuation problem has now been considered as the most important issue to improve the performance MPS method. So far there are some ways been suggested to solve the problem, but the pressure fluctuation can not be erased fundamentally by any of those. To deal with the problem, Tamai, Koshizuka had proposed a higher-order accuracy differential model that can properly take into account the spatial arrangement of particles. However, this model has just been proposed 2013 and not been well verified when applied to simulation. The present study has firstly comfirmed that compare to the old methods, Tamai, Koshizuka's new model can solve the problem more effectively. Secondly, we try to use the new differential model to do the dam-break simulation which is a classical benchmark for free-surface issues. However, we found that the new model has problems when dealing with the Neumann boundary condition. So we proposed a new way of setting the Neumann boundary condition in order to use the new differential model correctly, and finially got a very good result in the simulation.

  18. Renal Function and NODM in De Novo Renal Transplant Recipients Treated with Standard and Reduced Levels of Tacrolimus in Combination with EC-MPS

    Chan, Laurence; Andres, Amado; Bunnapradist, Suphamai; Gugliuzza, Kristene; Parasuraman, Ravi; Peddi, V. Ram; Cassuto, Elisabeth; Hart, Marquis

    2012-01-01

    Information is lacking concerning concomitant administration of enteric-coated mycophenolate sodium with tacrolimus (EC-MPS+Tac) in renal transplant recipients (RTxR). In this 6-month, prospective, open-label, multicenter study, de novo RTxR were randomized (1 : 1) to low-dose (LD) or standard-dose (SD) Tac with basiliximab, EC-MPS 720 mg bid, and steroids. Primary objective was to compare renal function at 6-month posttransplantation. Secondary objectives were to compare the incidences of biopsy-proven acute rejection (BPAR), graft loss and death, and new-onset diabetes mellitus (NODM). 292 patients (LD n = 151, SD n = 141) were included. Mean Tac levels were at the low end of the target range in standard-exposure patients (SD, n = 141) and exceeded target range in low-exposure patients (LD = 151) throughout the study. There was no significant difference in mean glomerular filtration rate (GFR) between treatments (ITT-population: 63.6 versus 61.0 mL/min). Incidence of BPAR was similar (10.6% versus 9.9%). NODM was significantly less frequent in LD Tac (17% versus 31%; P = 0.02); other adverse effects (AEs) were comparable. EC-MPS+Tac (LD/SD) was efficacious and well tolerated with well-preserved renal function. No renal function benefits were demonstrated, possibly related to poor adherence to reduced Tac exposure. PMID:23227307

  19. Effect of MPS concentration on ripening kinetics and structural properties of CdS quantum dots in self-assembled thin films

    Koc, Kenan

    2015-12-01

    The colloidal CdS quantum dots (QDs) were synthesized with various molar ratios of 3-mercaptopropyltrimethoxysilane (MPS) molecules. The results show that the smaller size of CdS QDs was obtained at the higher molar concentration of MPS. Sol-gel spin coating method was used for deposition of the colloidal nanoparticles on a glass substrate. One pot production method was used to obtain self-assembled thin films of CdS QDs in SiO2 network and the grow kinetics of QDs were investigated. The samples were heat treated at various temperatures to observe the growth of the QDs. The sizes of the QDs were obtained in the range of 2-5nm depending on the capping agent concentration and heat-treatment temperature. The activation energies for the Ostwald ripening process were found as 38.7, 56.4, 93,1 and 98.6kJ/mol for the samples containing molar ratio of MPS:Cd=0.25, 0.50, 1.00 and 2.00 respectively.

  20. Evidence for mutualism between a plant growing in a phosphate-limited desert environment and a mineral phosphate solubilizing (MPS) rhizobacterium.

    Goldstein; Braverman; Osorio

    1999-12-01

    Alkaline desert soils are high in insoluble calcium phosphates but deficient in soluble orthophosphate (Pi) essential for plant growth. In this extreme environment, one adaptive strategy could involve specific associations between plant roots and mineral phosphate solubilizing (MPS) bacteria. The most efficient MPS phenotype in Gram-negative bacteria results from extracellular oxidation of glucose to gluconic acid via the quinoprotein glucose dehydrogenase. A unique bacterial population isolated from the roots of Helianthus annus jaegeri growing at the edge of an alkaline dry lake in the Mojave Desert showed no MPS activity and no gluconic acid production. Addition of a concentrated solution containing material washed from the roots to these bacteria in culture resulted in production of high levels of gluconic acid. This effect was mimicked by addition of the essential glucose dehydrogenase redox cofactor 2,7,9-tricarboxyl-1H-pyrrolo[2,3]-quinoline-4,5-dione (PQQ) but the bioactive component was not PQQ. DNA hybridization data confirmed that this soil bacterium carried a gene with homology to the Escherichia coli quinoprotein glucose dehydrogenase. These data suggest that expression of the direct oxidation pathway in this bacterium may be regulated by signaling between the bacteria and the plant root. The resultant acidification of the rhizosphere may play a role in nutrient availability and/or other ecophysiological parameters essential for the survival of this desert plant. PMID:10568838

  1. Developing the SMF manipulator vehicle system

    After the Chernobyl accident, the experience accumulated there was incorporated in a list of specifications underlying the design and construction of a heavy-duty manipulator-vehicle, the tendering procedure for which, under the label of 'SMF', was opened in 1988. The vehicle is to be delivered to its operator in 1993 as the most powerful tool of its kind worldwide. SMF will meet the most stringent requirements with respect to dimensions, installed power, load bearing capacity, and precision. The electronic components of the control and data transmission systems in particular had to be developed from scratch. SMF is a mobile remotely controlled working tool which will be able to reach any location in and around nuclear installations and, in the process, will be able to handle with precision even the heaviest loads. (orig.)

  2. Development of Venturi System for Microbubble Generation

    This study was conducted with the aim of developing a venturi-type air supply system for a microbubble generator. In order to determine the influence of the varying geometry of the venturi tube on the flow characteristics, a computational fluid dynamics (CFD) simulation was performed using the commercial CFD software ANSYS CFX-15. Furthermore, in order to elucidate the effects of variation in major design dimensions such as the air supply hole size, position of holes, and number of holes on the air supply characteristics, two-phase multiflow CFD analysis was performed. The analysis results showed that the starting point of expansion on the venturi tube with 0.75 is the best hole position and that the air supply hole size and the number of holes are linearly proportional to the amount of air

  3. Development of nuclear data base system

    Following scope of tasks are performed to establish the nuclear data base which is the infra structure for the nuclear related research and industry. - Upgrade of Table of Nuclides web service and addition of new feature to existing ENDF plotting services. - Establishment of nuclear structures data base. Reconstruction of nuclear structure (ENSDF) data base with up-to-date data. - Establishment of nuclear reaction data base. Collection of the experimental reaction database (EXFOR). Collection of the evaluated nuclear reaction data libraries. Development of data retrieval programs. - Group constant library generation and verification. Generation of MATXS group constant library for thermal reactor application and verification against U-235 cores. Improvement of the cross section library preparation system for the MCNP code. (author). 15 refs., 8 tabs., 8 figs

  4. Development of CRD stub tube welding system

    The reactor pressure vessel (RPV) of nuclear power plants include control rod drive (CRD) stub tubes installed on the inner surface of the bottom head by welding. Weld seams are located at the root of each stub tube, to which accessibility is limited. The weld travel requires an elliptical movement with inclination along the inner bottom head surface, and furthermore the location on the bottom head of each stub tube has different angle of inclination. CRD stub tubes were installed by skilled welders using MIG welding in previous RPV construction. Recently, a CRD stub tube TIG welding system was developed for RPV construction in the near future, which can be applied to such 3 dimensional welding orbit. (author)

  5. The development of the JET electromagnetic system

    A series of enhancements of the JET apparatus is in the process of being implemented to increase the fusion parameter nsub(iD)Tsub(i)?sub(E) to values required for meaningful D-T operation. Modifications to the electromagnetic system (magnets, power supplies and plasma control) are major features of the new JET development plans, for operation with magnetic limiter up to 4MA and with material limiter up to 7MA. If the electromagnetic, thermal and mechanical assessment of the machine and power supplies, now underway, shows that the indicated extensions of the JET engineering operating space are possible, flat top currents of duration 10s and magnitude 4 and 7MA will be achieved in magnetic and material limiter configurations, respectively. (author)

  6. Reliable Software Development for Machine Protection Systems

    Anderson, D; Dragu, M; Fuchsberger, K; Garnier, JC; Gorzawski, AA; Koza, M; Krol, K; Misiowiec, K; Stamos, K; Zerlauth, M

    2014-01-01

    The Controls software for the Large Hadron Collider (LHC) at CERN, with more than 150 millions lines of code, resides amongst the largest known code bases in the world1. Industry has been applying Agile software engineering techniques for more than two decades now, and the advantages of these techniques can no longer be ignored to manage the code base for large projects within the accelerator community. Furthermore, CERN is a particular environment due to the high personnel turnover and manpower limitations, where applying Agile processes can improve both, the codebase management as well as its quality. This paper presents the successful application of the Agile software development process Scrum for machine protection systems at CERN, the quality standards and infrastructure introduced together with the Agile process as well as the challenges encountered to adapt it to the CERN environment.

  7. Design and Development of Robot Hand System

    Panchumarthy Seetharamaiah

    2011-01-01

    Full Text Available Research on robot hand design is being carried out to accommodate a variety of tasks such as grasping and manipulation of objects in the field of industrial applications, service robots and rehabilitation robots. Problem statement: To design and develop a microcontroller-based four fingered robotic hand with a simple and minimal control strategy to pick and place application with object detection by simple IR sensor logic. Approach: The methodology is based on anthropomorphic design with three fingers and an opposing thumb. Each finger has three links and three double revolute joints. Each finger is actuated by a single opposing pair of tendons. The robot hand system is interfaced to microcontroller with software control by means of 14 independent commands for the motion of joints: close and open for fore finger, middle finger, ring finger and thumb finger and wrist up and down, base clockwise and counter clockwise, pick and place and home position. The tendoning system and wireless feedback logic provide the hand with the ability to confirm to object topology and therefore providing the advantage of using a simple control structure. Results: Reliable grasping and releasing is achieved with simple control mechanisms and IR sensors/push-button switches. The hand can pick a variety of objects with different surface characteristics and shapes without having to reconstruct its surface description. Picking of the object is successfully completed as long as the object is within the workspace of the hand and placed the object at the desired position within the workspace by relevant software control using keyboard commands. Conclusion: Hardware and software development of microcontroller-based four-fingered robotic hand is addressed. Details of hand control software for mainly pick and place applications are presented. Results of the experimental work for pick and place application of different objects is enumerated.

  8. Development of portable driving simulator system

    Y. Itoh

    2008-08-01

    Full Text Available Purpose: In accordance with aging of populations in many developed countries, number of drivers who suffer from mild cognitive impairment (MCI drivers is increasing. Since it has been reported that driving skill of the MCI drivers are deteriorated, it is important to train themselves in driving situation to preserve their driving skills. The present study was conducted to develop the simple driving simulator system, and to examine the effect of training in this system.Design/methodology/approach: Nineteen university students (8 males and 11 females participated in this study. After the habituation period (approximately 5min, three trials (approximately 12 min were conducted. Experimental situation imitated the real highway course. During trials, dangerous situation that would be resulted in car accident is randomly appeared and participants were required to avoid the car accidents. To avoid the possible car accidents are considered as correct response.Findings: Mean percent of correct responses for male and female were 75.2% and 56.6% in 1st trial and 95.7% and 72.6% in 3rd trial, respectively. Two-way analysis of variance revealed that the main effect of sex(F (1, 14 = 7.84, p < .05 and trials (F (2, 34 = 10.19, p < .001. These results indicate that numbers of car accidents are dramatically decreased and the driving skills of male are superior to that of female.Practical implications: Although the present study revealed the differences in driving skills between the sexes, their driving history was not considered. Driving history of each participant should be examined in future study.Originality/value: Since the improvement of driving skills is revealed, our experimental design is expected as the tool for the preservation of driving skills in the MCI drivers.

  9. The development of KAERI management information system (II) -The development of Time Sheet Management System-

    The purpose of this report is to describe the work done for the development, operation and maintenance of Time Sheet Management System. This work is a part of the development KAERI management information system. Manpower management is essential to cope with the external circumstances promptly and to maximize the productivity of the organization. This work aims at setting up a basis for the manpower management system. It is widely recognized that neither timely decision making nor competitive edge can be secured with the traditional management technology in so a rapidly changing situations home and abroad, which can be characterized by openness and informality. The necessity of efficient and scientific man-power management by time-study has emerged on the reorganization of KAERI by expanding matrix system in order to enhance the R and D productivity. (Author)

  10. Systems approach to nuclear waste glass development

    Development of a host solid for the immobilization of nuclear waste has focused on various vitreous wasteforms. The systems approach requires that parameters affecting product performance and processing be considered simultaneously. Application of the systems approach indicates that borosilicate glasses are, overall, the most suitable glasses for the immobilization of nuclear waste. Phosphate glasses are highly durable; but the glass melts are highly corrosive and the glasses have poor thermal stability and low solubility for many waste components. High-silica glasses have good chemical durability, thermal stability, and mechanical stability, but the associated high melting temperatures increase volatilization of hazardous species in the waste. Borosilicate glasses are chemically durable and are stable both thermally and mechanically. The borosilicate melts are generally less corrosive than commercial glasses, and the melt temperature miimizes excessive volatility of hazardous species. Optimization of borosilicate waste glass formulations has led to their acceptance as the reference nuclear wasteform in the United States, United Kingdom, Belgium, Germany, France, Sweden, Switzerland, and Japan

  11. Development of clearance automatic laser inspection system

    A practical clearance level inspection system -CLALIS (Clearance Automatic Laser Inspection System) has been developed using laser shape measurement and Monte Carlo calculations in order to quantify very low activity in metal waste. CLALIS consists of four laser scanners, eight large plastic scintillation detectors at the upper and lower sides of the radiation measurement area surrounded by a 5-cm-thick lead shield. By using the digital configuration data of waste, two Monte Carlo simulations are carried out to calculate the calibration factor and the correction factor for background (BG) reduction due to the self-shielding effect of the waste during the radiation measurement. The accuracies of the calibration and BG correction were experimentally evaluated using mock metal waste of various types of shapes, numbers and sizes with radioactive sources of Co-60 and Cs-137. The detection limit of CLALIS, conservativeness and uncertainness of activity estimation were also evaluated with considering practical measurements. This report completes the study concerning practical survey tool for clearance level inspection of metal waste. (author)

  12. Information System on Occupational Exposure: Future Developments

    In response to pressures from deregulation and from ageing of the global nuclear power plant fleet, radiation protection personnel have found that occupational exposures are best managed through proper job planning, implementation and review to ensure that exposures are 'as low as reasonably achievable'(ALARA). A prerequisite for applying the principle of optimisation to occupational radiation protection is the timely exchange of data and information on dose reduction methods. To facilitate this global approach to work management, the OECD Nuclear Energy Agency (Nea) launched the Information System on Occupational Exposure (I.S.O.E.) in 1992. The objective of I.S.O.E. is to provide a forum for radiation protection experts from both utilities and national regulatory authorities to discuss, promote and coordinate international cooperative undertakings for the radiological protection of workers at nuclear power plants.The I.S.O.E. programme offers a variety of products in the occupational exposure area, such as: the world largest database on occupational exposure from nuclear power plants, a yearly analysis of dose trends and an overview of current developments, through I.S.O.E. Annual Reports, detailed studies, analyses, and information on current issues in operational radiation protection, through I.S.O.E. Information Sheets, a system for rapid communication of radiation protection-related information, such as effective dose reduction approaches and implementation of work management principles. A forum for discussing occupational exposure management issues through I.S.O.E. workshops, symposia and newsletters. (N.C.)

  13. BAE systems' SMART chip camera FPA development

    Sengupta, Louise; Auroux, Pierre-Alain; McManus, Don; Harris, D. Ahmasi; Blackwell, Richard J.; Bryant, Jeffrey; Boal, Mihir; Binkerd, Evan

    2015-06-01

    BAE Systems' SMART (Stacked Modular Architecture High-Resolution Thermal) Chip Camera provides very compact long-wave infrared (LWIR) solutions by combining a 12 μm wafer-level packaged focal plane array (FPA) with multichip-stack, application-specific integrated circuit (ASIC) and wafer-level optics. The key innovations that enabled this include a single-layer 12 μm pixel bolometer design and robust fabrication process, as well as wafer-level lid packaging. We used advanced packaging techniques to achieve an extremely small-form-factor camera, with a complete volume of 2.9 cm3 and a thermal core weight of 5.1g. The SMART Chip Camera supports up to 60 Hz frame rates, and requires less than 500 mW of power. This work has been supported by the Defense Advanced Research Projects Agency's (DARPA) Low Cost Thermal Imager - Manufacturing (LCTI-M) program, and BAE Systems' internal research and development investment.

  14. The development of the JET electromagnetic system

    A series of enhancements of the JET apparatus is in the process of being implemented to increase the fusion parameter eta/sub iD/T/sub i/tau/sub E/ to values required for meaningful D - T operation. Modifications to the electromagnetic system (magnets, power supplies and plasma control) are major features of the new JET development plans, for operation with magnetic limiter up to 4MA and with material limiter up to 7MA. Operation at these levels, well above design values, requires compensation of stray fields at breakdown, control of plasma current derivative during the early phase of the discharge, larger currents in the primary windings of the transformer (coil I) and arrangements for establishing magnetic limiter configurations. To this end coil I will be made a 10 subcoil stack (now 8), a fast rise voltage shaping circuit and a DC power supply will be added to the present JET poloidal system, and the radial field control will be modified to cater for the magnetic limiter configuration with both one and two X-points. If the electromagnetic, thermal and mechanical assessment of the machine and power supplies, now underway, shows that the indicated extensions of the JET engineering operations space are possible, flat top current s of duration 10s and magnitude 4 and 7MA will be achieved in magnetic and material limiter configurations, respectively

  15. Development of advanced reprocessing system 'FLUOREX'

    The nuclear fuel reprocessing technology 'FLUOREX' is a hybrid system that combines fluoride volatility and solvent extraction methods, where the major U in spent fuel is separated as UF6 gas efficiently by the fluoride volatility method and MOX is recovered by well-established conventional PUREX like process which, however, does not have uranium-plutonium partitioning part for strong proliferation resistance. The system can recover pure U and MOX with a decontamination factor of over 107 and can drastically reduce costs compared with the conventional one. From 2001 to 2004, we carried out the examination for the fundamental process of FLUOREX. The investigation have been continued from 2004 to 2007 from the viewpoint of the engineering of flame reactor control, the development of systems such as decladding, UF6 purification including the trace Pu recovery process using UO2F2 adsorbent, and the conversion of MOX resources, and the influence of fluorine on the dissolution and extraction processes. We concluded that from those experimental results, key processes of FLUOREX are fundamentally proved. From 2008 to 2010, we carried out the important investigation for advanced stage of UF6 purification, recovery of PuF6, conversion of fluoride FPs to oxide, and effect of fluorine on material in the solvent extraction process. The UF6 purification process was examined in the semi-engineering scale using a flame reactor and absorbent traps. We got the prospect for UF6 purification using fluoride absorbents such as NaF and MgF2. We studied recovery of PuF6 by UO2F2 absorbent in small apparatus using Pu, Np and Tc. The engineering scale test of oxide conversion demonstrated that the rotary kiln was applicable for conversion process of non-volatile fluoride FPs to oxides. Effect of fluorine on material in the solvent extraction was examined with corrosion test and electrochemical analysis. These results demonstrated the applicability of FLUOREX to new generation reprocessing. (author)

  16. Development of generation IV nuclear energy systems

    The fifth 'Generation IV International Forum (GIF), Policy Group Meetings' was held at the Zen-Nikku Hotel in Tokyo, on September 19-20, 2002, under participations of Abraham, Secretary of DOE in U.S.A., Columbani, Secretary of CEA in France, Fujiie, Chairman of CAE in Japan, Kano, Parliamental Minister of MIS in Japan, and so on. Ten nations entering GIF (Argentina, Brazil, Canada, France, Japan, Korea, South Africa, Switzerland, U.K., and U.S.A.) selected six next generation nuclear energy concepts for objects of international cooperative research and development aiming at its practice by 2030. These concepts applicable to not only power generation, but also hydrogen production, sea water purification, and so on, are sodium liquid metal cooled reactor (Japan), high temperature gas cooled reactor (France), Super-critical pressure water cooled reactor (SCWR: Canada), Lead metal cooled reactor (Switzerland), Gas cooled fast reactor (U.S.A.), and molten salts reactor. On the generation IV nuclear reactor systems aiming to further upgrade their sustainability, safety, economical efficiency, and nuclear non proliferation, the 'Plans on Technical Development' (Road-map) to decide priority of their R and Ds has been cooperatively discussed under frameworks of international research cooperation by the GIF members nations. Here were shared descriptions on nuclear fuel cycle as a remise of technical evaluation and adopted concepts by Japanese participants contributing to making up the Road-map. (G.K.)

  17. Development of shielding design analysis system

    The aim of this work is to develop insufficient auxiliary routines which manage input and output data and interface the main codes and to establish a shielding design analysis system on work stations (SUN, DEC). In shielding design analyses, one- and two- dimensional (1-D and 2-D) transport Sn codes are used mainly with some auxiliary codes which generate input data of Sn calculation and edit Sn calculation outputs. The main transport calculation codes can be obtained from the Code Center of RIST (Research Organization for Information Science and Technology). In this work, peripheral codes are developed to generate cross sections, produce Sn quadrature sets, edit calculation outputs or draw contour figures. In shielding calculations around a reactor, the boot-strapping technique is often employed to treat a large area extending from the core to the biological shield to improve the calculation accuracy. When a three-dimensional (3-D) calculation for a complex geometry with shielding defects, 2-D and 3-D coupling calculation is employed frequently. To use this coupling method conversion cods are prepared which read flux file from DORT and prepare an external boundary source file for the 2-D or the 3-D calculation codes. For further conveniences well used data such as the Sn quadrature sets, the dose rate conversion factors, the reaction cross section sets are stored as a data base and code manuals including sample inputs of typical problems are prepared which are comprehensible to beginners. (author)

  18. Development of the excretory system in a polyplacophoran mollusc: stages in metanephridial system development

    Baeumler Natalie

    2012-09-01

    Full Text Available Abstract Background Two types of excretory systems, protonephridia and metanephridial systems are common among bilaterians. The homology of protonephridia of lophotrochozoan taxa has been widely accepted. In contrast, the homology of metanephridial systems – including coelomic cavities as functional units – among taxa as well as the homology between the two excretory systems is a matter of ongoing discussion. This particularly concerns the molluscan kidneys, which are mostly regarded as being derived convergently to the metanephridia of e.g. annelids because of different ontogenetic origin. A reinvestigation of nephrogenesis in polyplacophorans, which carry many primitive traits within molluscs, could shed light on these questions. Results The metanephridial system of Lepidochitona corrugata develops rapidly in the early juvenile phase. It is formed from a coelomic anlage that soon achieves endothelial organization. The pericardium and heart are formed from the central portion of the anlage. The nephridial components are formed by outgrowth from lateral differentiations of the anlage. Simultaneously with formation of the heart, podocytes appear in the atrial wall of the pericardium. In addition, renopericardial ducts, kidneys and efferent nephroducts, all showing downstream ciliation towards the internal lumen, become differentiated (specimen length: 0.62 mm. Further development consists of elongation of the kidney and reinforcement of filtration and reabsorptive structures. Conclusions During development and in fully formed condition the metanephridial system of Lepidochitona corrugata shares many detailed traits (cellular and overall organization with the protonephridia of the same species. Accordingly, we suggest a serial homology of various cell types and between the two excretory systems and the organs as a whole. The formation of the metanephridial system varies significantly within Mollusca, thus the mode of formation cannot be used as a homology criterion. Because of similarities in overall organization, we conclude that the molluscan metanephridial system is homologous with that of the annelids not only at the cellular but also at the organ level.

  19. Development of the excretory system in a polyplacophoran mollusc: stages in metanephridial system development

    2012-01-01

    Background Two types of excretory systems, protonephridia and metanephridial systems are common among bilaterians. The homology of protonephridia of lophotrochozoan taxa has been widely accepted. In contrast, the homology of metanephridial systems – including coelomic cavities as functional units – among taxa as well as the homology between the two excretory systems is a matter of ongoing discussion. This particularly concerns the molluscan kidneys, which are mostly regarded as being derived convergently to the metanephridia of e.g. annelids because of different ontogenetic origin. A reinvestigation of nephrogenesis in polyplacophorans, which carry many primitive traits within molluscs, could shed light on these questions. Results The metanephridial system of Lepidochitona corrugata develops rapidly in the early juvenile phase. It is formed from a coelomic anlage that soon achieves endothelial organization. The pericardium and heart are formed from the central portion of the anlage. The nephridial components are formed by outgrowth from lateral differentiations of the anlage. Simultaneously with formation of the heart, podocytes appear in the atrial wall of the pericardium. In addition, renopericardial ducts, kidneys and efferent nephroducts, all showing downstream ciliation towards the internal lumen, become differentiated (specimen length: 0.62 mm). Further development consists of elongation of the kidney and reinforcement of filtration and reabsorptive structures. Conclusions During development and in fully formed condition the metanephridial system of Lepidochitona corrugata shares many detailed traits (cellular and overall organization) with the protonephridia of the same species. Accordingly, we suggest a serial homology of various cell types and between the two excretory systems and the organs as a whole. The formation of the metanephridial system varies significantly within Mollusca, thus the mode of formation cannot be used as a homology criterion. Because of similarities in overall organization, we conclude that the molluscan metanephridial system is homologous with that of the annelids not only at the cellular but also at the organ level. PMID:22973977

  20. Performance improvements of differential operators code for MPS method on GPU

    Murotani, Kohei; Masaie, Issei; Matsunaga, Takuya; Koshizuka, Seiichi; Shioya, Ryuji; Ogino, Masao; Fujisawa, Toshimitsu

    2015-09-01

    In the present study, performance improvements of the particle search and particle interaction calculation steps constituting the performance bottleneck in the moving particle simulation method are achieved by developing GPU-compatible algorithms for many core processor architectures. In the improvements of particle search, bucket loops of the cell-linked list are changed to a loop structure having fewer local variables and the linked list and the forward star of particle search algorithms within a bucket are compared. In the particle interaction calculation, the problem of the ratio of particles within the interaction domain to the neighboring particle candidates being quite low is improved. By these improvements, a performance efficiency of 24.7 % can be achieved for the first-order polynomial approximation scheme using NVIDIA Tesla K20, CUDA-6.5, and double-precision floating-point operations.