WorldWideScience

Sample records for system mps development

  1. MPS II drift chamber system

    Energy Technology Data Exchange (ETDEWEB)

    Platner, E.D.

    1982-01-01

    The MPS II detectors are narrow drift space chambers designed for high position resolution in a magnetic field and in a very high particle flux environment. Central to this implementation was the development of 3 multi-channel custom IC's and one multi-channel hybrid. The system is deadtimeless and requires no corrections on an anode-to-anode basis. Operational experience and relevance to ISABELLE detectors is discussed.

  2. MPS Data Acquisition System

    International Nuclear Information System (INIS)

    A description is given of the data acquisition system used with the multiparticle spectrometer facility at Brookhaven. Detailed information is provided on that part of the system which connects the detectors to the data handler; namely, the detector electronics, device controller, and device port optical isolator

  3. Charged particle detector system for the MPS and ISABELLE spectrometers

    International Nuclear Information System (INIS)

    A detector system combining the good time resolution and low dead time to PWC's and the good space resolution of drift chambers is proposed to upgrade the MPS and for future use in Isabelle spectrometers. Central to this detector is the development of two integrated electronic circuit systems. The detectors are described with special emphasis on the electronic systems. The detector system proposed will be capable of handling particle flux rates typical of conventional PWC's yet providing a spacial resolution of 100 ?m. Another advantage is that a large area detector of such performance will become technically feasible as well as economically viable

  4. MPS data-acquisition software system

    International Nuclear Information System (INIS)

    A description of the software for a FASTBUS based data-acquisition system in use at the Brookhaven National Laboratory Multiparticle Spectrometer is presented. Data reading and formating is done by the SLAC scanner processors (SSP's) resident in the FASTBUS system. A multiprocess software system on VAX computers is used to communicate with the SSP's, record the data, and monitor on-line the progress of high energy and heavy ions experiments. The structure and the performance of this system are discussed. (orig.)

  5. DET/MPS - THE GSFC ENERGY BALANCE PROGRAM, DIRECT ENERGY TRANSFER/MULTIMISSION SPACECRAFT MODULAR POWER SYSTEM (UNIX VERSION)

    Science.gov (United States)

    Jagielski, J. M.

    1994-01-01

    The DET/MPS programs model and simulate the Direct Energy Transfer and Multimission Spacecraft Modular Power System in order to aid both in design and in analysis of orbital energy balance. Typically, the DET power system has the solar array directly to the spacecraft bus, and the central building block of MPS is the Standard Power Regulator Unit. DET/MPS allows a minute-by-minute simulation of the power system's performance as it responds to various orbital parameters, focusing its output on solar array output and battery characteristics. While this package is limited in terms of orbital mechanics, it is sufficient to calculate eclipse and solar array data for circular or non-circular orbits. DET/MPS can be adjusted to run one or sequential orbits up to about one week, simulated time. These programs have been used on a variety of Goddard Space Flight Center spacecraft projects. DET/MPS is written in FORTRAN 77 with some VAX-type extensions. Any FORTRAN 77 compiler that includes VAX extensions should be able to compile and run the program with little or no modifications. The compiler must at least support free-form (or tab-delineated) source format and 'do do-while end-do' control structures. DET/MPS is available for three platforms: GSC-13374, for DEC VAX series computers running VMS, is available in DEC VAX Backup format on a 9-track 1600 BPI tape (standard distribution) or TK50 tape cartridge; GSC-13443, for UNIX-based computers, is available on a .25 inch streaming magnetic tape cartridge in UNIX tar format; and GSC-13444, for Macintosh computers running AU/X with either the NKR FORTRAN or AbSoft MacFORTRAN II compilers, is available on a 3.5 inch 800K Macintosh format diskette. Source code and test data are supplied. The UNIX version of DET requires 90K of main memory for execution. DET/MPS was developed in 1990. A/UX and Macintosh are registered trademarks of Apple Computer, Inc. VMS, DEC VAX and TK50 are trademarks of Digital Equipment Corporation. UNIX is a registered trademark of AT&T Bell Laboratories.

  6. Development of a Lagrangian Meshless Flow Solver based on the Moving Particle Semi-implicit (MPS) Method

    International Nuclear Information System (INIS)

    This paper discusses on the development of a meshless flow solver based on the Lagrangian particle method. The differential operators are discretised by using the particle interaction models proposed in the numerical framework of the Moving Particle Semi-implicit (MPS) technique. The MPS method is attractive from the viewpoint of no mesh is required and fluid is purely represented by points (the virtue of meshless algorithm). Some flow applications attempted by the current meshless solver will be shown and results are compared with the published experimental data.

  7. Development of a Lagrangian Meshless Flow Solver based on the Moving Particle Semi-implicit (MPS) Method

    Science.gov (United States)

    Ng, K. C.; Ng, Y. L.; Yusoff, M. Z.

    2013-06-01

    This paper discusses on the development of a meshless flow solver based on the Lagrangian particle method. The differential operators are discretised by using the particle interaction models proposed in the numerical framework of the Moving Particle Semi-implicit (MPS) technique. The MPS method is attractive from the viewpoint of no mesh is required and fluid is purely represented by points (the virtue of meshless algorithm). Some flow applications attempted by the current meshless solver will be shown and results are compared with the published experimental data.

  8. DET/MPS - THE GSFC ENERGY BALANCE PROGRAM, DIRECT ENERGY TRANSFER/MULTIMISSION SPACECRAFT MODULAR POWER SYSTEM (MACINTOSH A/UX VERSION)

    Science.gov (United States)

    Jagielski, J. M.

    1994-01-01

    The DET/MPS programs model and simulate the Direct Energy Transfer and Multimission Spacecraft Modular Power System in order to aid both in design and in analysis of orbital energy balance. Typically, the DET power system has the solar array directly to the spacecraft bus, and the central building block of MPS is the Standard Power Regulator Unit. DET/MPS allows a minute-by-minute simulation of the power system's performance as it responds to various orbital parameters, focusing its output on solar array output and battery characteristics. While this package is limited in terms of orbital mechanics, it is sufficient to calculate eclipse and solar array data for circular or non-circular orbits. DET/MPS can be adjusted to run one or sequential orbits up to about one week, simulated time. These programs have been used on a variety of Goddard Space Flight Center spacecraft projects. DET/MPS is written in FORTRAN 77 with some VAX-type extensions. Any FORTRAN 77 compiler that includes VAX extensions should be able to compile and run the program with little or no modifications. The compiler must at least support free-form (or tab-delineated) source format and 'do do-while end-do' control structures. DET/MPS is available for three platforms: GSC-13374, for DEC VAX series computers running VMS, is available in DEC VAX Backup format on a 9-track 1600 BPI tape (standard distribution) or TK50 tape cartridge; GSC-13443, for UNIX-based computers, is available on a .25 inch streaming magnetic tape cartridge in UNIX tar format; and GSC-13444, for Macintosh computers running AU/X with either the NKR FORTRAN or AbSoft MacFORTRAN II compilers, is available on a 3.5 inch 800K Macintosh format diskette. Source code and test data are supplied. The UNIX version of DET requires 90K of main memory for execution. DET/MPS was developed in 1990. A/UX and Macintosh are registered trademarks of Apple Computer, Inc. VMS, DEC VAX and TK50 are trademarks of Digital Equipment Corporation. UNIX is a registered trademark of AT&T Bell Laboratories.

  9. DET/MPS - THE GSFC ENERGY BALANCE PROGRAM, DIRECT ENERGY TRANSFER/MULTIMISSION SPACECRAFT MODULAR POWER SYSTEM (DEC VAX VMS VERSION)

    Science.gov (United States)

    Jagielski, J. M.

    1994-01-01

    The DET/MPS programs model and simulate the Direct Energy Transfer and Multimission Spacecraft Modular Power System in order to aid both in design and in analysis of orbital energy balance. Typically, the DET power system has the solar array directly to the spacecraft bus, and the central building block of MPS is the Standard Power Regulator Unit. DET/MPS allows a minute-by-minute simulation of the power system's performance as it responds to various orbital parameters, focusing its output on solar array output and battery characteristics. While this package is limited in terms of orbital mechanics, it is sufficient to calculate eclipse and solar array data for circular or non-circular orbits. DET/MPS can be adjusted to run one or sequential orbits up to about one week, simulated time. These programs have been used on a variety of Goddard Space Flight Center spacecraft projects. DET/MPS is written in FORTRAN 77 with some VAX-type extensions. Any FORTRAN 77 compiler that includes VAX extensions should be able to compile and run the program with little or no modifications. The compiler must at least support free-form (or tab-delineated) source format and 'do do-while end-do' control structures. DET/MPS is available for three platforms: GSC-13374, for DEC VAX series computers running VMS, is available in DEC VAX Backup format on a 9-track 1600 BPI tape (standard distribution) or TK50 tape cartridge; GSC-13443, for UNIX-based computers, is available on a .25 inch streaming magnetic tape cartridge in UNIX tar format; and GSC-13444, for Macintosh computers running AU/X with either the NKR FORTRAN or AbSoft MacFORTRAN II compilers, is available on a 3.5 inch 800K Macintosh format diskette. Source code and test data are supplied. The UNIX version of DET requires 90K of main memory for execution. DET/MPS was developed in 1990. A/UX and Macintosh are registered trademarks of Apple Computer, Inc. VMS, DEC VAX and TK50 are trademarks of Digital Equipment Corporation. UNIX is a registered trademark of AT&T Bell Laboratories.

  10. National MPS Society (Mucopolysaccharidoses)

    Science.gov (United States)

    ... III Treatments Therapy Options Treatments ERT FDA Workshop: ERT Immune Response Treatments HSCT What Are Clinical Trials? Treatment Clinical Trials Clinical Research Studies Emerging Treatments Palliative Care Newborn Screening MPS I ...

  11. Replacement of heavy components of the Main Primary System (MPS). Recent innovations made by Framatome ANP

    International Nuclear Information System (INIS)

    The replacement of heavy components is the result of widespread stress corrosion of Inconel 600 (and alloys 82/182) in the primary system. Following the corrosion of steam generator tubes, which led to the first steam generator replacement (SGR) operations, work has begun on reactor vessel head replacements (RVHR) and pressurizer replacements, pending treatment of the dissimilar butt welds (DBW). The replacement of sections of the Main Primary System is one way of optimizing plant lifetime besides preventing stress corrosion in primary components and combating phenomena as thermal fatigue or certain metallurgical weaknesses. The increase in the number of major operations carried out in the reactor building on PWR and BWR reactor geometries has called for major technical innovations. AREVA, has over the past twenty years carried out more than forty SGRs throughout the world, including the supply of 115 steam generators of all types. This equates to over 60% of all SGR operations performed in Europe and the USA. Today, most SGR operations are performed in the USA, though some still continue in Europe and Asia. Operations have been planned until 2015. The first RVHR operations were carried out in France in 1993, and have been widespread in Europe since 1996 (Spain and Belgium), and in the USA since 2002 (Davis Besse). Since 1993 AREVA, through its subsidiaries Framatome ANP, Jeumont SA and SGT, has performed 72 RVHRs, i.e. most of those carried out in Europe and the USA.f those carried out in Europe and the USA. Today, RVHR operations take place throughout the world and have been planned until 2014. The first pressurizer replacement took place in the fall of 2005 in Saint Lucie, USA. Others are to follow (Fort Calhoun, Millestone). A significant number of partial or complete pressurizer replacements are now being scheduled. Special focus must be given to this new operation, as a decision is required between the following types of replacements, taking into account the number of pressurizer heaters and the condition of the various penetrations (lateral or from above, for instrumentation, unloading, spraying, etc.): - Complete replacement of the component (including dissimilar metal welds, thermal sleeves and even a section of the surge line if necessary); - Bottom replacement; - Replacement of faulty penetrations only. Along with the regular replacement of molded Main Primary System elbows (SGR operations), the following actions have also been carried out: - Replacement of a half crossover leg (SGR-GR4, 2000); - Replacement of a cold leg section (RCLS) with a chemical and volume control system (CVCS) nozzle (SGR-FH1, 2002). In the future we predict work will be carried out on the pressurizer surge line (potentially carried out as part of a pressurizer changeover or as a stand-alone operation). This presentation will focus on the major innovations developed by Framatome ANP, aided by its international customers in order to carry out these primary component replacement operations as well and as quickly as possible. These innovations concern the following domains: - Hoisting and handling; - Metrology and topo-metry; - Machining and welding; - Automated operations in piping; - Operation management. In conclusion one stresses that to increase the lifetime of their nuclear plants, optimize outages and sometimes increase thermal and electrical power it is necessary to optimize the replacement of heavy primary components. To meet the operator needs, suppliers must in turn enhance their capacity and skills in terms of: - Providing near-turnkey services (supplies and work); - Orchestrating these operations (i.e. by performing the duties of an engineering department); - Providing services in a range of fields, from concrete to instrumentation and control, and even performance testing; - Being technically innovative in all of these areas. Since the 1990's, with the assistance of its worldwide customer base, Framatome ANP has been carrying out this approach thanks to its experience as a vendor and manufacturer (OEM), bolstered by the capa

  12. Development of the machine protection system for LCLS-I

    International Nuclear Information System (INIS)

    Machine Protection System (MPS) requirements for the currently operating Linac Coherent Light Source (LCLSI) demand that fault detection and mitigation occur within one machine pulse (1/120 of a second at full beam rate). The MPS must handle inputs from a variety of sources including loss monitors as well as standard state-type inputs. These sensors exist at various places across the full 2.5 Km length of the accelerator and beam lines. A new MPS has been developed based on a distributed star network where custom-designed local hardware nodes handle sensor inputs and mitigation outputs for localized regions of the LCLS accelerator complex. These Link- Nodes report status information and receive action commands from a centralized processor running the MPS algorithm over a private network. The individual Link-Node is a 3u chassis with configurable hardware components that can be setup with digital and analog inputs and outputs, depending upon the sensor and actuator requirements. Features include a custom MPS digital input/output subsystem, a private Ethernet interface, an embedded processor, a custom MPS engine implemented in an FPGA and an Industry Pack (IP) bus interface, allowing COTS and custom analog/digital I/O modules to be utilized for MPS functions. These features, while capable of handling standard MPS state-type inputs and outputs, allow other systems like beam loss monitors to be completely integrated within it. To date, four different types of Link-Nodes adate, four different types of Link-Nodes are in use in LCLS-I. This paper describes the design, construction and implementation of the LCLS MPS with a focus on the Link-Node, which has proven to be a very useful and flexible component for the MPS. (authors)

  13. France’s deliberately opaque expenses system means that it is paying more than its neighbours for MPs: but this may be about to change

    OpenAIRE

    Murray, Rainbow

    2012-01-01

    In 2009, the UK government was rocked by a scandal over its MPs’ expenses. According to Rainbow Murray, France is now due a similar scandal, as MPs’ expenses are not currently scrutinised, and many hold multiple offices (and draw multiple salaries). While the new Socialist government is taking measures to address these problems, it remains to be seen if they will be truly effective in reforming French MPs’ culture of entitlement.

  14. Space Shuttle Program (SSP) Orbiter Main Propulsion System (MPS) Gaseous Hydrogen (GH2) Flow Control Valve (FCV) Poppet Eddy Current (EC) Inspection Probability of Detection (POD) Study. Volume 2; Appendices

    Science.gov (United States)

    Piascik, Robert S.; Prosser, William H.

    2011-01-01

    The Director of the NASA Engineering and Safety Center (NESC), requested an independent assessment of the anomalous gaseous hydrogen (GH2) flow incident on the Space Shuttle Program (SSP) Orbiter Vehicle (OV)-105 during the Space Transportation System (STS)-126 mission. The main propulsion system (MPS) engine #2 GH2 flow control valve (FCV) LV-57 transition from low towards high flow position without being commanded. Post-flight examination revealed that the FCV LV-57 poppet had experienced a fatigue failure that liberated a section of the poppet flange. The NESC assessment provided a peer review of the computational fluid dynamics (CFD), stress analysis, and impact testing. A probability of detection (POD) study was requested by the SSP Orbiter Project for the eddy current (EC) nondestructive evaluation (NDE) techniques that were developed to inspect the flight FCV poppets. This report contains the Appendices to the main report.

  15. Space Shuttle Program (SSP) Orbiter Main Propulsion System (MPS) Gaseous Hydrogen (GH2) Flow Control Valve (FCV) Poppet Eddy Current (EC) Inspection Probability of Detection (POD) Study. Volume 1

    Science.gov (United States)

    Piascik, Robert S.; Prosser, William H.

    2011-01-01

    The Director of the NASA Engineering and Safety Center (NESC), requested an independent assessment of the anomalous gaseous hydrogen (GH2) flow incident on the Space Shuttle Program (SSP) Orbiter Vehicle (OV)-105 during the Space Transportation System (STS)-126 mission. The main propulsion system (MPS) engine #2 GH2 flow control valve (FCV) LV-57 transition from low towards high flow position without being commanded. Post-flight examination revealed that the FCV LV-57 poppet had experienced a fatigue failure that liberated a section of the poppet flange. The NESC assessment provided a peer review of the computational fluid dynamics (CFD), stress analysis, and impact testing. A probability of detection (POD) study was requested by the SSP Orbiter Project for the eddy current (EC) nondestructive evaluation (NDE) techniques that were developed to inspect the flight FCV poppets. This report contains the findings and recommendations from the NESC assessment.

  16. Optimization of the SODAR preprocessor MPS

    International Nuclear Information System (INIS)

    The data measured by meteorological monitoring stations at the site of nuclear installations form the basis for calculation and fast assessment of the atmospheric dispersion of radionuclides released in an accident, and the resulting population exposure. Application of modern atmospheric dispersion models, as eg. that of the French-German Commission (DFK model), requires a novel calculation method for determination of boundary layer parameters based on SODAR information and supplementary meteorological measurements. For the research project St. Sch. 4102, the meteorological preprocessor for SODAR data (MPS) has been developed and is explained in the reports /THI 96/ and THI 98/. The task of the research project St.Sch. 4166 reported here was to optimize the MPS and carry out relevant validations. (orig./CB)

  17. Why all MPs should support reforming the electoral system: it is a key step in restoring their own legitimacy with the public

    OpenAIRE

    Dunleavy, Patrick

    2010-01-01

    Most arguments about electoral reform are thinly veiled cloaks for partisan self-interest. By contrast Patrick Dunleavy argues that, whatever your party, there is now an overwhelming public interest case for adopting the Alternative Vote – to restore to all MPs genuine majority support in their locality. This is the crucial first step in restoring the tattered legitimacy of Parliament. Not adopting this reform would condemn MPs to ever-worsening status in the eyes of their local communities...

  18. MPS beam control software architecture

    International Nuclear Information System (INIS)

    The new Machine Protection System (MPS) now being tested at SLAC has a beam control subsystem resident in processors located close to the beam monitoring devices within the machine. There are two types of beam control micros: Algorithm Processors (AP's) which collect and evaluate data from monitoring devices, and a Supervisor (SUPE) which collects and evaluates data from all the AP's. The SUPE also receives the global machine beamcode indicating beam presence, and passes it on to the AP's. The SUPE receives the beamcode pattern from the Master Pattern Generator (MPG) via a shared-memory communication link. MIL-1553 serial communication is used between the SUPE and the AP's, and between the AP's and the monitoring devices. Multitasking software is used to allow high priority handling of data evaluation and low priority handling of host/user interfacing and event reporting. Pipelining of data between acquisition and evaluation and reporting is used to accomodate the processing capacity, while still supporting full processing at the 360Hz broadcast rate of the beamcode pattern

  19. MPS beam control software architecture

    International Nuclear Information System (INIS)

    The new Machine Protection System (MPS) now being tested at SLAC has a beam control subsystem resident in processors located close to the beam monitoring devices within the machine. There are two types of beam control micros: Algorithm Processors (AP's) which collect and evaluate data from monitoring devices, and a Supervisor (SUPE) which collects and evaluates data from all the AP's. The SUPE also receives the global machine beamcode indicating beam presence, and passes it on to the AP's. The SUPE receives the beamcode pattern from the Master Pattern Generator (MPG) via a shared-memory communication link. MIL-1553 serial communication is used between the SUPE and the AP's, and between the AP's and the monitoring devices. Multitasking software is used to allow high priority handling of data evaluation and low priority handling of host/user interfacing and event reporting. Pipelining of data between acquisition and evaluation and reporting is used to accommodate the processing capacity, while still supporting full processing at the 36OHz broadcast rate of the beamcode pattern

  20. Spectroscopy of MPS(3):DAMS(+) composite materials

    Science.gov (United States)

    Holt, Jennifer Suzanne

    Composite materials are comprised of two separate components that are brought together to form a new material that exhibits unique properties not found in the individual components. The composite material studied in this work is a guest dye cation, (4-[4-(dimethylamino)-alpha-styrl]-1-methylpyridinium) or DAMS+, intercalated into an inorganic host lattice (MPS 3, where M = Cd2+ or Mn2+). MPS3 :DAMS+ exhibits high-efficiency second-harmonic generation (SHG), which is only observed when a material lacks a center of symmetry. There must be an organization of dye molecules upon intercalation to induce the noncentrosymmetry necessary for SHG. The formation of dye aggregates will be studied as a possible noncentrosymmetric arrangement. The intercalated materials (MPS3:DAMS+) exhibited spectral features of J-aggregates. These features included a sharp aggregate absorption and emission band, known as the J-band. There was a small Stokes shift (250 cm-1) between aggregate absorption and emission bands, and a red-shift between the J-band and isolated dye absorption band (3,700 cm-1). The low-energy tail of the emission J-band was theoretically modeled using the Urbach-Martienssen equation, while the high-energy states were fit to a Gaussian to determine aggregate disorder. Disorder was also modeled using a Monte-Carlo lineshape analysis program. From these theoretical models, the aggregate was found to be two-dimensional and weakly coupled. A variety of sample types were studied including intercalated powders and single crystals using absorbance, reflectance and emission spectroscopy. Reflectance spectra were directly compared with absorbance spectra using the Kramers-Kronig Transformation2 to determine that the surface aggregates and the interior aggregates were structurally similar. A new imaging microspectrophotometer was developed to investigate the topology of the composite materials. Kinetics of the intercalation front were studied and a layer-by-layer intercalation mechanism was developed. Surface studies using other materials indicated the polyanion nature of MPS3 :DAMS+ was essential for aggregation. Infrared microspectroscopy was used to determine the orientation of dye molecules on the surface of the large composite crystals. The DAMS+ in MPS 3:DAMS+ was shown to form two-dimensional brickwork aggregates with the molecules aligned "edge-on" on the surface and interior of the host lattice.

  1. Mechanism for complex mode MPS

    International Nuclear Information System (INIS)

    J-PARC is composite facility mainly on the accelerators with multiple experiment area. One trouble influences the whole, because the accelerator is commonly used. The high intensity is a goal on this facilities. It does not agree with the aim with that the down time is big. It was proposed that the down time could be reduced, if composition of the accelerator and linkage of the experiment area are analyzed, and if the appropriate operation is done. Proposed change would be carried out in the near future. Since the beginning, we have done the design in which the complicated selection is possible for the MPS of MR. The logic of the MPS which can deal with the complicated situation is introduced. (author)

  2. Health-Related Quality of Life in Patients with MPS II.

    Science.gov (United States)

    Needham, Mary; Packman, Wendy; Quinn, Natasha; Rappoport, Maxwell; Aoki, Christa; Bostrom, Alan; Cordova, Matthew; Macias, Sandra; Morgan, Cynthia; Packman, Seymour

    2014-11-14

    Mucopolysaccharidosis type II (MPS II), also known as Hunter syndrome, is a chronic and progressive X-linked lysosomal disease that mainly affects males. The National MPS Society (2013) reports that MPS II affects 1 in 100,000 to 1 in 150,000 males worldwide. Two distinct forms of the disease are based on age of onset and clinical course: attenuated and severe. MPS II affects many organ systems including the nervous, cardiovascular, gastrointestinal and respiratory systems. Clinical manifestations can include progressive hearing loss, mental impairment, and enlarged liver and spleen. This study focuses on the health-related quality of life of individuals (HRQOL) with MPS II as measured by the parent and self-report versions of the Pediatric Quality of Life Inventory (PedsQL™). Both parents of patients with MPS II as well as patients themselves reported lower scores on all domains of the PedsQL™ (physical, emotional, social and school functioning) indicating that children with MPS II have an overall lower HRQOL when compared to a healthy sample. When compared with patients with other chronic illnesses (cancer, MSUD, galactosemia,), the MPS II sample had significantly lower scores on a number of PedsQL™ scales, suggesting an overall lower HRQOL. No significant relationships were found using scores from parent or self report PedsQL™ measures and length of time on ERT. PMID:25395377

  3. Efficient MPS algorithm for periodic boundary conditions and applications

    OpenAIRE

    Weyrauch, Michael; Rakov, Mykhailo V.

    2013-01-01

    We present an implementation of an efficient algorithm for the calculation of the spectrum of one-dimensional quantum systems with periodic boundary conditions. This algorithm is based on a matrix product representation for quantum states (MPS), and a similar representation for Hamiltonians and other operators (MPO). It is significantly more efficient for systems of about 100 sites and more than for small quantum systems. We apply the formalism to calculate the ground state ...

  4. Reversed papilledema in an MPS VI patient with galsulfase (Naglazyme®) therapy

    OpenAIRE

    Koseoglu, Selim T.; Harmatz, Paul; Turbeville, Sean; Nicely, Helen

    2008-01-01

    MPS VI (mucopolysaccharidosis VI, known as Maroteaux–Lamy syndrome) is a multi-systemic inherited disease, resulting from a deficiency of N-acetylgalactosamine-4-sulfatase, causing accumulation of the glycosaminoglycan (GAG) dermatan sulfate in all tissues. It is one of almost 50 lysosomal storage disorders. Ocular pathology is common in patients with MPS VI, with complications including ocular hypertension, progressive corneal clouding, optic nerve swelling (or papilledema) often associate...

  5. A simple algorithm to search for all d-MPs with unreliable nodes

    International Nuclear Information System (INIS)

    Many real-world systems are multistate systems composed of multistate components in which the reliability can be computed in terms of the lower bound points of level d, by formulating in terms of either the d-minimal paths (d-MPs) or d-minimal cutsets (d-MCs). Such systems (electric power, transportation, etc.) may be regarded as flow networks whose arcs have independent, discrete, limited and multivalued random capacities. A simple method is proposed to search for all d-MPs for network reliability in a system subject to both arc and node failures. The proposed method does not require re-enumeration for all of the d-MPs or MPs for the additional the node failure consideration. Because only the sum of the flow through into (or from) each unreliable node of the d-MPs which found in the network with perfect nodes is calculated, the proposed algorithm is easier to understand and implement. With considering unreliable nodes, this method is also more realistic and valuable for performing the reliability analysis in an existing network. The computational complexity of the proposed algorithm is analyzed and compared with the existing methods. One example is illustrated to show how all d-MPs are generated in a network with arc and node failures solved by the proposed algorithm

  6. The meiotic defects of mutants in the Drosophila mps1 gene reveal a critical role of Mps1 in the segregation of achiasmate homologs.

    Science.gov (United States)

    Gilliland, William D; Wayson, Sarah M; Hawley, R Scott

    2005-04-12

    The conserved kinase Mps1 is necessary for the proper functioning of the mitotic and meiotic spindle checkpoints (MSCs), which monitor the integrity of the spindle apparatus and prevent cells from progressing into anaphase until chromosomes are properly aligned on the metaphase plate. In Drosophila melanogaster, a null allele of the gene encoding Mps1 was recently shown to be required for the proper functioning of the MSC, but it did not appear to exhibit a defect in female meiosis. We demonstrate here that the meiotic mutant ald1 is a hypomorphic allele of the mps1 gene. Both ald1 and a P-insertion allele of mps1 exhibit defects in female meiotic chromosome segregation. The observed segregational defects are substantially more severe for pairs of achiasmate homologs, which are normally segregated by the achiasmate (or distributive) segregation system, than they are for chiasmate bivalents. Furthermore, cytological analysis of ald1 mutant oocytes reveals both a failure in the coorientation of achiasmate homologs at metaphase I and a defect in the maintenance of the chiasmate homolog associations that are normally observed at metaphase I. We conclude that Mps1 plays an important role in Drosophila female meiosis by regulating processes that are especially critical for ensuring the proper segregation of nonexchange chromosomes. PMID:15823541

  7. Fully-automated field mapping of a dipole magnet of a multi-passage spectrometer (MPS)

    Energy Technology Data Exchange (ETDEWEB)

    Meissner, Robert; Thirolf, Peter; Weber, Christine [Fakultaet fuer Physik, LMU - Muenchen (Germany)

    2013-07-01

    MLLTRAP is a Penning-trap mass-spectrometer facility, which is currently being commissioned at the Maier-Leibnitz Laboratory in Garching. Here, atomic mass values are determined by measuring cyclotron frequencies of stored ions in a strong magnetic field. In the future, highly-charged ions should be utilized for an improvement in the achievable mass accuracy. For this purpose, singly-charged ions will have to be injected into a charge-breeding device, such as an EBIT, and transferred back towards the Penning traps, while being q/A selected. To fulfill these tasks a multi-passage-spectrometer (MPS) is being built. It consists of a fast-ramping, round-pole dipole magnet with an electrostatic mirror system. A basic requirement for building the MPS is a detailed knowledge on the magnetic field produced by the magnet. It is necessary to simulate the trajectories of the ions and gain knowledge on the design and geometry of the electrostatic mirror system and the vacuum chamber. For this purpose, a robot was designed, which - powered by three step motors - measures the magnetic field fully automated. The robot moves a Hall probe within three dimensions with a resolution of 1 mm and an uncertainty of 0.5 mm. In this presentation, the development of the robot, its control and data acquisition via LabView and the results are presented.

  8. Develop and Evaluate the Effects of Multimodal Presentation System on Elementary ESL Students

    Science.gov (United States)

    Kuo, Fang-O; Yu, Pao-Ta; Hsiao, Wei-Hung

    2013-01-01

    The purpose of this study is to develop and evaluate the effects of multimodal presentation system (MPS), a multimodal presentation software integrated with interactive whiteboard (IWB), on student learning in the elementary English as second language (ESL) course. It focuses primarily on techniques and tools to enhance the students' ESL…

  9. Reservoir Modeling by Data Integration via Intermediate Spaces and Artificial Intelligence Tools in MPS Simulation Frameworks

    International Nuclear Information System (INIS)

    Conditioning stochastic simulations are very important in many geostatistical applications that call for the introduction of nonlinear and multiple-point data in reservoir modeling. Here, a new methodology is proposed for the incorporation of different data types into multiple-point statistics (MPS) simulation frameworks. Unlike the previous techniques that call for an approximate forward model (filter) for integration of secondary data into geologically constructed models, the proposed approach develops an intermediate space where all the primary and secondary data are easily mapped onto. Definition of the intermediate space, as may be achieved via application of artificial intelligence tools like neural networks and fuzzy inference systems, eliminates the need for using filters as in previous techniques. The applicability of the proposed approach in conditioning MPS simulations to static and geologic data is verified by modeling a real example of discrete fracture networks using conventional well-log data. The training patterns are well reproduced in the realizations, while the model is also consistent with the map of secondary data

  10. BNL multiparticle spectrometer (MPS) program

    International Nuclear Information System (INIS)

    The design and operation of the BNL multiparticle spectrometer are described. Also a formation experiment anti pp ? n/sub c/ ? final state was studied at 3.7 to 4.2 GeV/c tuning the total cm energy of the anti pp system to lie near the just below the J mass to search for the existence of a narrow peak (J/sup PC/ = O/sup -+ /GAMMA? several MeV). No outstanding peak is seen, but an approximate cross section limit is given in the region of a few microbarns. There is a clear K0 signal. Also a plot of the effective mass and missing mass for events with two neutral K's produced by 8.7-GeV/c ?- on hydrogen is given

  11. Development of fast beam-stop system using RF chopper

    International Nuclear Information System (INIS)

    To avoid heat damage and radioactivation by beam loss of the J-PARC accelerator, Machine Protection System (MPS) has been developed. Actually, high responsibility and high reliability have been achieved in J-PARC. Beam-stop method in addition to a way of RFQ OFF has been requested in order to avoid damage to the RFQ. Therefore, we have been developing a fast beam-stop system by using a RF chopper. The fast beam-stop system, including beam test, is described in this paper. (author)

  12. The viStaMPS tool for visualization and manipulation of time series interferometric results

    Science.gov (United States)

    Sousa, Joaquim J.; Magalhães, Luis G.; Ruiz, Antonio M.; Sousa, António M. R.; Cardoso, Gil

    2013-03-01

    In the last decade, Synthetic Aperture Radar Interferometry (InSAR) has become operational as a technique that allows remote detection of deformation at the Earth's surface. Analysis of time series of SAR images extends the area where InSAR can be successfully applied and also permits detection of smaller displacements through the reduction of error sources. Stanford Method for Persistent Scatterers (StaMPS) InSAR implementation, which is based on the processing of multi-temporal SAR data, is widely used for ground deformation monitoring. This is due mainly to its proven reliability and freeware distribution among the scientific community. However, some issues can make the interpretation of the results a difficult task: StaMPS supports data processing based on command prompt, which increases the difficulty of usage by users not familiar with the specific programming language that supports StaMPS. Moreover, several visualization tasks are not implemented in the standard approach requiring that each user develop its own code for visualization and interpretation purposes. In this paper, we present viStaMPS, a new visual application developed to enhance the visualization, manipulation and exportation of StaMPS results. The programmed application is developed in Matlab through the Graphical User Interface (GUI) and no coding is required for running it, which avoids any programming language knowledge for standard uses. The included graphical interface is very versatile allowing the user to choose among several features: visualization, manipulation and exportation of data which are not available in the original StaMPS.

  13. Numerical analysis of fuel-coolant interactions in coolant injection mode using MPS

    International Nuclear Information System (INIS)

    The numerical method used in this study is the Moving Particle Semi-implicit (MPS) method which is based on moving particles and their interactions. Grids are not necessary, so that large fluid deformation can be calculated without numerical diffusion. Boiling and solidification models are developed for the MPS method. Melt injection is calculated considering boiling and solidification. Clusters of melt particles appear due to solidification. To understand the fundamental physics of the jet penetration, water jet injection into a pool of a denser fluid under non-boiling and isothermal conditions are calculated using the MPS method. The density ratio of the denser fluid to water is 1.88 (fluorinert) or 9.4 (anatomical alloy). The calculation results are compared with experiments, which were conducted in the ALPHA/MUSE facility at JAERI. In the calculation, air entrainment is observed as the experiments due to the jet penetration. However, the maximum jet penetration depth is shallower than the experiments. (author)

  14. Email and political campaigning: the experience of MPs in Westminster

    Directory of Open Access Journals (Sweden)

    Nigel Jackson

    2004-04-01

    Full Text Available Traditionally individual politicians communicated directly with their constituents, but the arrival of the mass media, especially television, eroded the role of direct communication. The development of new Information Communication Technologies (ICTs is now re-opening the use of direct communication as part of post-modern campaigning (Norris 2000, with the Internet providing an alternative to media relations. The World Wide Web has attracted great interest from political commentators, but so far email has been largely ignored. Yet the Web is a pull technique, whereas the push nature of email opens up new campaigning possibilities. Downes and Mui (2000 suggest that email represents potentially a 'killer app' which might revolutionize the way MPs approach re-election. A survey of Members of Parliament (MPs Assembly Members (AMs of the Welsh Assembly and Members of the Scottish Parliament (MSPs examines whether they have grasped the opportunities email represents. The research suggests that the outbound use of email for campaigning purposes is limited to a small number of pioneers. Resources, parliamentary culture and party affiliation all shape the use of email campaigning.

  15. 77 FR 43071 - MPS Customer Group v. Maine Public Service Company; Notice of Complaint

    Science.gov (United States)

    2012-07-23

    ...No. EL12-84-000] MPS Customer Group v. Maine Public Service Company; Notice of Complaint...18 CFR 385.206, MPS Customer Group (Complainant) filed...complaint against Maine Public Service Company (MPS or...

  16. Characterization of novel MPS1 inhibitors with preclinical anticancer activity.

    Science.gov (United States)

    Jemaà, M; Galluzzi, L; Kepp, O; Senovilla, L; Brands, M; Boemer, U; Koppitz, M; Lienau, P; Prechtl, S; Schulze, V; Siemeister, G; Wengner, A M; Mumberg, D; Ziegelbauer, K; Abrieu, A; Castedo, M; Vitale, I; Kroemer, G

    2013-11-01

    Monopolar spindle 1 (MPS1), a mitotic kinase that is overexpressed in several human cancers, contributes to the alignment of chromosomes to the metaphase plate as well as to the execution of the spindle assembly checkpoint (SAC). Here, we report the identification and functional characterization of three novel inhibitors of MPS1 of two independent structural classes, N-(4-{2-[(2-cyanophenyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}phenyl)-2-phenylacetamide (Mps-BAY1) (a triazolopyridine), N-cyclopropyl-4-{8-[(2-methylpropyl)amino]-6-(quinolin-5-yl)imidazo[1,2-a]pyrazin-3-yl}benzamide (Mps-BAY2a) and N-cyclopropyl-4-{8-(isobutylamino)imidazo[1,2-a]pyrazin-3-yl}benzamide (Mps-BAY2b) (two imidazopyrazines). By selectively inactivating MPS1, these small inhibitors can arrest the proliferation of cancer cells, causing their polyploidization and/or their demise. Cancer cells treated with Mps-BAY1 or Mps-BAY2a manifested multiple signs of mitotic perturbation including inefficient chromosomal congression during metaphase, unscheduled SAC inactivation and severe anaphase defects. Videomicroscopic cell fate profiling of histone 2B-green fluorescent protein-expressing cells revealed the capacity of MPS1 inhibitors to subvert the correct timing of mitosis as they induce a premature anaphase entry in the context of misaligned metaphase plates. Hence, in the presence of MPS1 inhibitors, cells either divided in a bipolar (but often asymmetric) manner or entered one or more rounds of abortive mitoses, generating gross aneuploidy and polyploidy, respectively. In both cases, cells ultimately succumbed to the mitotic catastrophe-induced activation of the mitochondrial pathway of apoptosis. Of note, low doses of MPS1 inhibitors and paclitaxel (a microtubular poison) synergized at increasing the frequency of chromosome misalignments and missegregations in the context of SAC inactivation. This resulted in massive polyploidization followed by the activation of mitotic catastrophe. A synergistic interaction between paclitaxel and MPS1 inhibitors could also be demonstrated in vivo, as the combination of these agents efficiently reduced the growth of tumor xenografts and exerted superior antineoplastic effects compared with either compound employed alone. Altogether, these results suggest that MPS1 inhibitors may exert robust anticancer activity, either as standalone therapeutic interventions or combined with microtubule-targeting chemicals. PMID:23933817

  17. Reversed papilledema in an MPS VI patient with galsulfase (Naglazyme) therapy.

    Science.gov (United States)

    Koseoglu, Selim T; Harmatz, Paul; Turbeville, Sean; Nicely, Helen

    2009-08-01

    MPS VI (mucopolysaccharidosis VI, known as Maroteaux-Lamy syndrome) is a multi-systemic inherited disease, resulting from a deficiency of N-acetylgalactosamine-4-sulfatase, causing accumulation of the glycosaminoglycan (GAG) dermatan sulfate in all tissues. It is one of almost 50 lysosomal storage disorders. Ocular pathology is common in patients with MPS VI, with complications including ocular hypertension, progressive corneal clouding, optic nerve swelling (or papilledema) often associated with communicating hydrocephalus (Ashworth et al., Eye 20(5), 553-563, 2006; Goldberg et al., AJO 69(6), 969-975), and raised intracranial pressure (ICP) progressing to atrophy with loss of vision (Goodrich et al., Loss of vision in MPS VI is a consequence of increased intracranial pressure, 2002). This is the first case report of reversed papilledema and improved visual acuity in an 11-year-old MPS VI patient receiving galsulfase (Naglazyme), an enzyme-replacement therapy (ERT) of recombinant human arylsulfatase B (rhASB) (Harmatz et al., J Pediatr 148(4), 533-539, 2006). PMID:18418554

  18. The Staphylococcus aureus NuoL-Like Protein MpsA Contributes to the Generation of Membrane Potential.

    Science.gov (United States)

    Mayer, Sonja; Steffen, Wojtek; Steuber, Julia; Götz, Friedrich

    2015-03-01

    In aerobic microorganisms, the entry point of respiratory electron transfer is represented by the NADH:quinone oxidoreductase. The enzyme couples the oxidation of NADH with the reduction of quinone. In the type 1 NADH:quinone oxidoreductase (Ndh1), this reaction is accompanied by the translocation of cations, such as H(+) or Na(+). In Escherichia coli, cation translocation is accomplished by the subunit NuoL, thus generating membrane potential (??). Some microorganisms achieve NADH oxidation by the alternative, nonelectrogenic type 2 NADH:quinone oxidoreductase (Ndh2), which is not cation translocating. Since these enzymes had not been described in Staphylococcus aureus, the goal of this study was to identify proteins operating in the NADH:quinone segment of its respiratory chain. We demonstrated that Ndh2 represents a NADH:quinone oxidoreductase in S. aureus. Additionally, we identified a hypothetical protein in S. aureus showing sequence similarity to the proton-translocating subunit NuoL of complex I in E. coli: the NuoL-like protein MpsA. Mutants with deletion of the nuoL-like gene mpsA and its corresponding operon, mpsABC (mps for membrane potential-generating system), exhibited a small-colony-variant-like phenotype and were severely affected in ?? and oxygen consumption rates. The MpsABC proteins did not confer NADH oxidation activity. Using an Na(+)/H(+) antiporter-deficient E. coli strain, we could show that MpsABC constitute a cation-translocating system capable of Na(+) transport. Our study demonstrates that MpsABC represent an important functional system of the respiratory chain of S. aureus that acts as an electrogenic unit responsible for the generation of ??. PMID:25448817

  19. Circulating microparticles in systemic Lupus Erythematosus.

    Science.gov (United States)

    Nielsen, Christoffer Tandrup

    2012-11-01

    Systemic lupus erythematosus (SLE) is a systemic autoimmune disease presenting with a wide array of clinical manifestations and an elusive pathogenesis. A characteristic feature in SLE is the occurrence of autoantibodies against chromatin, double-stranded DNA, and RNA-binding ribonucleoproteins. Observations of defective clearance of dying cells in SLE combined with the generation and exposure of nuclear autoantigens during apoptosis have led to the hypothesis that improperly cleared apoptotic debris constitutes a source of autoantigens capable of triggering autoimmune disease. In blood, circulating, heterogeneous subcellular microparticles (MPs) are released from cells and platelets constitutively and upon cellular activation or apoptosis. Such MPs may reflect the state of their parental cells and tissues, and could serve as markers of pathology. Particular in SLE MPs may serve as carriers of autoantigens and constituents of immune complexes (ICs). The purposes of this PhD thesis were to develop and apply qualitative and quantitative methods to characterize circulating MPs with respect to numbers, cellular origins and composition in a large cohort of well-characterized SLE patients compared to healthy and disease controls and to explore associations with clinical, biochemical and serological parameters. The PhD thesis consists of a review and three papers. In the first paper we show that SLE patients have significantly decreased numbers of annexin V binding MPs and MPs from platelets, leukocytes and endothelial cells using flow cytometry. Two morphologically distinguishable populations of annexin V non-binding MPs were increased in the SLE patients. The annexin V non-binding MPs of most likely cellular origin were associated with the presence of lupus nephritis, markers of increased disease activity and levels of endothelial cell-derived MPs. In the second paper we present the development of a proteomic method to characterize the protein composition of purified MPs using high-resolution mass spectrometry and establish a set of proteins which may serve as normalizers for MP protein quantitation enabling comparison across samples and studies. We identify a core proteome of more than 330 proteins in MPs from healthy individuals. The method enables an unbiased, comprehensive coverage of all proteins present in MPs irrespectively of the availability and utility of immunological reagents. In the third paper we use the established flow cytometry and mass spectrometry platforms to show that SLE-MPs carry more surface-bound IgG, IgM and C1q indicating that SLE-MPs could be antigenic targets and constituents of ICs. Additionally, the numbers of MPs carrying IgG are also increased in SLE. The load of IgG on SLE-MPs was associated with markers of complement activation, indicators of disease activity in SLE. In conclusion, using both antibody-dependent and independent methods we demonstrate that SLE-MPs deviate distinctly from controls and may serve as precursors of ICs associated with complement activation and disease activity. This supports the hypothesis of MPs being directly involved in or reflecting tissue-specific or systemic inflammation in addition to carrying accessible antigens. Accordingly, further characterization of the proteome and functional properties of SLE-MPs seem highly warranted in future studies. PMID:23171755

  20. The automation of the management of the MPS for J-PARC

    International Nuclear Information System (INIS)

    The machine protection system (MPS) for J-PARC MR is the equipment which stops the beam in the abnormal occurrence of the devices of the accelerator complex. Abnormality in this case is both of beam control abnormal and electric power source equipment trouble. The surveillance object of the MR-MPS is the equipment of about 70. By twin system for central processing of MR-MPS, the improvement in the reliability was attempted. For the real utilization operation, beam stop adjusted to one destination of MLF/MR was carried out. The register for the setting drastically increased by double check and careful operation of the stop area, and the number of the register became about 300. The situation which had exceeded the limit to my management arose in recent operation. Then, it is necessary to control all information by one system for the management with the reliability in the setting in respect of controlling and displaying management and setting verification and information for the equipment management. To solve this situation, the RDB is used for the data management and the automatic generation of the program group of management and display was undertaken. In this report, the briefing on these is carried out. (author)

  1. Future opportunities for hadron spectroscopy at the MPS

    International Nuclear Information System (INIS)

    Before I go into detailed MPS experiments, I will give a summary of the status of lattice gauge calculations of glueball masses plus glueball and hybrid masses from the bag model, and the flux tube model. For the following discussion, I am going to assume that multi-quark states or molecules are best described in terms of the MIT bag model of Jaffe with its spectrum best defined by work done by R.L. Jaffe and F.E. Low using a method called The P-Matrix. Using this method one sees that all 4-quark states will appear as very broad continuum like effects that one would not associate with meson resonances, except for the S* and the ? which forms a very special threshold K/bar K/ bound systems. There is a possibility that the E(1420) may also be related to the J/sup PC/ = 1++, qq/bar q//bar q/ spectrum having its width narrowed by a final state interaction

  2. Nano-WO3 film modified macro-porous silicon (MPS) gas sensor

    International Nuclear Information System (INIS)

    We prepared macro-porous silicon (MPS) by electrochemical corrosion in a double-tank cell on the surface of single-crystalline P-type silicon. Then, nano-WO3 films were deposited on MPS layers by DC facing target reactive magnetron sputtering. The morphologies of the MPS and WO3/MPS samples were investigated by using a field emission scanning electron microscope. The crystallization of WO3 and the valence of the W in the WO3/MPS sample were characterized by X-ray diffraction and X-ray photoelectron spectroscopy, respectively. The gas sensing properties of MPS and WO3/MPS gas sensors were thoroughly measured at room temperature. It can be concluded that: the WO3/MPS gas sensor shows the gas sensing properties of a P-type semiconductor gas sensor. The WO3/MPS gas sensor exhibits good recovery characteristics and repeatability to 1 ppm NO2. The addition of WO3 can enhance the sensitivity of MPS to NO2. The long-term stability of a WO3/MPS gas sensor is better than that of an MPS gas sensor. The sensitivity of the WO3/MPS gas sensor to NO2 is higher than that to NH3 and C2H5OH. The selectivity of the MPS to NO2 is modified by deposited nano-WO3 film. (semiconductor devices)

  3. Numerical analysis of film boiling of water at atmospheric pressure using MPS-MAFL method

    International Nuclear Information System (INIS)

    Film boiling is avoided to occur in the normal operation of nuclear power plant but it is expected that the film boiling will occur in reactor core and it play important role in post-accident core cooling. Numerical simulation on the development of the steam-water interface and heat transfer in the film boiling of water is performed using Moving Particle Semi-implicit with Meshless Advection using Flow-directional Local-grid(MPS-MAFL) method. The shape change of vapor film and the velocity distribution are coincident with those of experiments. The heat fluxes are compared with those of Berenson's equation for several cases of heater wall temperatures. The heat flux of MPS-MAFL calculation is somewhat lower than that of Berenson's analysis. The reason is because that the distance between computing points is too large for the calculation of heat transfer in a very thin thermal boundary layer and the film thickness is larger than that of real case. From these results, it becomes certain that the heat transfer is mainly affected by the thickness of vapor film and the wall superheat and the MPS-MAFL method is applicable to the film boiling where the phase interface is changed rapidly and complicatedly and the density ratio between the liquid and vapor phases is large

  4. A preliminary design proposal for a maritime patrol strike aircraft: MPS-2000 Condor

    Science.gov (United States)

    1994-01-01

    The four member graduate design team assembled to submit a proposal for the 1993/1994 RFP at the University of Kansas has designed a four seat, variable swept wing, twin turbofan aircraft with STOL capabilities. The aircraft is named the MPS-2000 Condor and is capable of carrying air-to-surface or air-to-air weapon systems along with attack and surveillance radar and IRF systems. The aircraft has a cruise range of 800 nautical miles, a loiter of 4 hours, and a dash speed of 500 kts.

  5. MRI morphometric characterisation of the paediatric cervical spine and spinal cord in children with MPS IVA (Morquio-Brailsford syndrome).

    Science.gov (United States)

    Solanki, Guirish A; Lo, William B; Hendriksz, Christian J

    2013-03-01

    Nearly all children with MPS IVA develop skeletal deformities affecting the spine. At the atlanto-axial spine, odontoid hypoplasia occurs. GAG deposition around the dens, leads to peri-odontoid infiltration. Transverse/alar ligament incompetence causes instability. Atlanto-axial instability is associated with cord compression and myelopathy, leading to major morbidity and mortality. Intervention is often required. Does the presence of widened bullet shaped vertebra in platyspondily encroach on the spinal canal and cause spinal stenosis in MPS IVA? So far, there have been no standardised morphometric measurements of the paediatric MPS IVA cervical spine to evaluate whether there is pre-existing spinal stenosis predisposing to compressive myelopathy or whether this is purely an acquired process secondary to instability and compression. This study provides the first radiological quantitative analysis of the cervical spine and spinal cord in a series of affected children. MRI morphometry indicates that the MPS IVA spine is narrower at C1-2 level giving an inverted funnel shape. There is no evidence of a reduction in the Torg ratio (canal-body ratio) in the cervical spine. The spinal canal does not exceed 11 mm at any level, significantly smaller than normal historical cohorts (14 mm). The sagittal diameter and axial surface area of both spinal canal and cord are reduced. C1-2 level cord compression was evident in the canal-cord ratio but the Torg ratio was not predictive of cord compression. In MPS IVA the reduction in the space available for the cord (SAC) is multifactorial rather than due to congenital spinal stenosis. PMID:23404316

  6. British Conservative women MPs and 'women's issues' 1950-1979

    OpenAIRE

    Haessly, Katie

    2010-01-01

    In the period 1950-1979, there were significant changes in legislation relating to women’s issues, specifically employment, marital and guardianship and abortion rights. This thesis explores the impact of Conservative female MPs on these changes as well as the changing roles of women within the party. In addition there is a discussion of the relationships between Conservative women and their colleagues which provides insights into the changes in gender roles which were occurring at this tim...

  7. w-MPS Risk Aversion and the CAPM

    OpenAIRE

    Boyle, Phelim P.; Chenghu Ma

    2013-01-01

    This paper establishes general conditions for the validity of mutual fund separation and the equilibrium CAPM. We use partial preference orders that display weak form mean preserving spread (w-MPS) risk aversion in the sense of Ma (2011). We derive this result without imposing any distributional assumptions on asset returns. The results hold even when the market contains an infinite number of securities and a continuum number of traders, and when each investor is permit...

  8. Intellectual and neurological functioning in Morquio syndrome (MPS IVa).

    Science.gov (United States)

    Davison, J E; Kearney, S; Horton, J; Foster, K; Peet, A C; Hendriksz, C J

    2013-03-01

    Mucopolysaccharidosis type IVa (MPS IVa, Morquio syndrome OMIM #253000) is a lysosomal storage disease caused by deficiency in N-acetylgalactosamine-6-sulfatase (GALNS, EC 3.1.6.4; encoded by GALNS gene at 16q24.3). Unlike other MPS disorders involving excessive heparan and dermatan sulfate, Morquio syndrome has not been associated with neurological involvement nor with intellectual impairment as this disorder of keratan sulfate has been described as a purely visceral and skeletal disorder. Neurocognitive assessment was undertaken of MPS IVa patients with age appropriate intellectual tests as well as a Child Behaviour Checklist as part of clinical follow up. Available neuroimaging studies (MRI and MR spectroscopy) were reviewed. Whilst more than half of the overall IQ scores fell in the average range, scores for 3/8 children fell below average. A number of behavioural problems were highlighted, including anxiety/depression, attention and somatic complaints. Subtle neuroimaging abnormalities were demonstrated in over half of the children. These findings present a challenge to existing assumptions about the nature of Morquio A syndrome. A hypothesis regarding the potential role of calcium signalling is explored. PMID:22231379

  9. Operation of the Brookhaven MPS II Facility

    International Nuclear Information System (INIS)

    The BNL Multiparticle Spectrometer has recently been equipped with a set of narrow cell drift chambers employing a novel, compact, inexpensive, readout scheme. This has given an order of magnitude improvement in beam rate as well as better spatial resolution. Two experiments have been completed in the first year of operation, a good test of the system. This type of a drift chamber arrangement is ideal for use at high luminosity hadron colliders

  10. MPS on the Hunt for Planets

    CERN Document Server

    Rhie, S H

    1999-01-01

    Planetary systems toward the Galactic Bulge can be detected through microlensing measurements. The microlensing planet search technique has some unique merits: low-mass planets can be detected from the ground; the Galactic family of planetary systems can be sampled unbiased; the time scale for the completion of each event is relatively short. The unambiguity of the underlying low-multiplicity point lenses is an indispensable element that allows robust interpretaion of the events. We have found the first circumbinary planet in the microlensing event MACHO-97-BLG-41. We have found evidence of a low mass planet (few Earths to Neptune mass) in a very high magnification event MACHO-98-BLG-35. We emphasize the necessity for coherent searches of microlensing planets with a network of instruments in the southern hemisphere. The network can also be vitally instrumental for follow-up observations of SN1a's and GRB's which share with microlensing planets the transiency as well as the clues to our quest of the origins.

  11. Performance of Four Newly Developed Upland Cotton Strains Under Lower Sindh Conditions

    OpenAIRE

    Chang, M. S.; Chang, M. A.; Lakho, A. R.; Soomro, A. W.; Memon, A. A.

    2002-01-01

    Four newly developed strains; MPS-2, MPS-4, MPS-7, and MPS-11, were tested against two commercial, high yielding varieties CRIS-9 and NIAB-78, for two years (1996 and 1997) for seed cotton yield per hectare, ginning out turn percentage (Got), staple length and boll weight. The highest yield of 2209 kg /ha was obtained by MPS-2, followed by MPS-11 (2090 kg /ha). The increase of top yielding strain MPS-2 over commercial varieties CRIS-9 and NIAB-78 were 13.7 and 18.3%, respectively. The h...

  12. Coupled Simulation of Seismic Wave Propagation and Failure Phenomena by Use of an MPS Method

    Science.gov (United States)

    Takekawa, Junichi; Mikada, Hitoshi; Goto, Tada-nori; Sanada, Yoshinori; Ashida, Yuzuru

    2013-04-01

    The failure of brittle materials, for example glasses and rock masses, is commonly observed to be discontinuous. It is, however, difficult to simulate these phenomena by use of conventional numerical simulation methods, for example the finite difference method or the finite element method, because of the presence of computational grids or elements artificially introduced before the simulation. It is, therefore, important for research on such discontinuous failures in science and engineering to analyze the phenomena seamlessly. This study deals with the coupled simulation of elastic wave propagation and failure phenomena by use of a moving particle semi-implicit (MPS) method. It is simple to model the objects of analysis because no grid or lattice structure is necessary. In addition, lack of a grid or lattice structure makes it simple to simulate large deformations and failure phenomena at the same time. We first compare analytical and MPS solutions by use of Lamb's problem with different offset distances, material properties, and source frequencies. Our results show that analytical and numerical seismograms are in good agreement with each other for 20 particles in a minimum wavelength. Finally, we focus our attention on the Hopkinson effect as an example of failure induced by elastic wave propagation. In the application of the MPS, the algorithm is basically the same as in the previous calculation except for the introduction of a failure criterion. The failure criterion applied in this study is that particle connectivity must be disconnected when the distance between the particles exceeds a failure threshold. We applied the developed algorithm to a suspended specimen that was modeled as a long bar consisting of thousands of particles. A compressional wave in the bar is generated by an abrupt pressure change on one edge. The compressional wave propagates along the interior of the specimen and is visualized clearly. At the other end of the bar, the spalling of the bar is reproduced numerically, and a broken piece of the bar is formed and falls away from the main body of the bar. Consequently, these results show that the MPS method effectively reproduces wave propagation and failure phenomena at the same time.

  13. Numerical analysis of molten core-concrete interaction using MPS method

    International Nuclear Information System (INIS)

    Moving particle semi-implicit (MPS) method uses particles for discretization of fluids. Governing equations are transformed to particle interactions. Grids are not necessary. This enables us to analyze multi-fluid and multi-phase flows with large deformation of interfaces. In the present study, a two-dimensional code is developed for molten core-concrete interaction (MCCI) based on the MPS method. Heat transfer is calculated without any specific correlations. Solid is simply represented by fixed particles. A particle can be changed to a moving (fluid) or fixed (solid) particle corresponding to its enthalpy. The developed code is applied to SWISS-2 experiment. The calculation geometry is x-y two dimensions though the experiment was r-z two dimensions. Nucleate boiling and radiation heat transfers are considered between the melt and the water pool. Only heat conduction is assumed among the melt pool, concrete and MgO (side wills). Natural convection in the melt pool is considered using Boussinesq's approximation. Gas release and volume contraction accompanied by the concrete ablation are ignored. Calculated heat flux to the water pool agrees well with the experiment, though the ablation speed in the concrete is a little slower. A stable crust is formed in a short time after water is poured in and the heat flux to the water pool rapidly decreases. The shape of the crust is like a bridge due to the natural convection in the melt pool. (author)

  14. MRI morphometric characterisation of the paediatric cervical spine and spinal cord in children with MPS IVA (Morquio-Brailsford syndrome)

    OpenAIRE

    Solanki, Guirish A.; Lo, William B.; Hendriksz, Christian J.

    2013-01-01

    Nearly all children with MPS IVA develop skeletal deformities affecting the spine. At the atlanto-axial spine, odontoid hypoplasia occurs. GAG deposition around the dens, leads to peri-odontoid infiltration. Transverse/alar ligament incompetence causes instability. Atlanto-axial instability is associated with cord compression and myelopathy, leading to major morbidity and mortality. Intervention is often required. Does the presence of widened bullet shaped vertebra in platyspondily encroach o...

  15. Regulation of Kinetochore Recruitment of Two Essential Mitotic Spindle Checkpoint Proteins by Mps1 Phosphorylation

    OpenAIRE

    Xu, Quanbin; Zhu, Songcheng; Wang, Wei; Zhang, Xiaojuan; Old, William; Ahn, Natalie; Liu, Xuedong

    2009-01-01

    Mps1 is a protein kinase that plays essential roles in spindle checkpoint signaling. Unattached kinetochores or lack of tension triggers recruitment of several key spindle checkpoint proteins to the kinetochore, which delays anaphase onset until proper attachment or tension is reestablished. Mps1 acts upstream in the spindle checkpoint signaling cascade, and kinetochore targeting of Mps1 is required for subsequent recruitment of Mad1 and Mad2 to the kinetochore. The mechanisms that govern rec...

  16. Evaluation of enzyme dose and dose-frequency in ameliorating substrate accumulation in MPS IIIA Huntaway dog brain.

    Science.gov (United States)

    King, Barbara; Marshall, Neil; Beard, Helen; Hassiotis, Sofia; Trim, Paul J; Snel, Marten F; Rozaklis, Tina; Jolly, Robert D; Hopwood, John J; Hemsley, Kim M

    2015-03-01

    Intracerebrospinal fluid (CSF) infusion of replacement enzyme is under evaluation for amelioration of disease-related symptoms and biomarker changes in patients with the lysosomal storage disorder mucopolysaccharidosis type IIIA (MPS IIIA; www.clinicaltrials.gov ; NCT#01155778; #01299727). Determining the optimal dose/dose-frequency is important, given the invasive method for chronically supplying recombinant protein to the brain, the main site of symptom generation. To examine these variables, we utilised MPS IIIA Huntaway dogs, providing recombinant human sulphamidase (rhSGSH) to young pre-symptomatic dogs from an age when MPS IIIA dog brain exhibits significant accumulation of primary (heparan sulphate) and secondary (glycolipid) substrates. Enzyme was infused into CSF via the cisterna magna at one of two doses (3 mg or 15 mg/infusion), with the higher dose supplied at two different intervals; fortnightly or monthly. Euthanasia was carried out 24 h after the final injection. Dose- and frequency-dependent reductions in heparan sulphate were observed in CSF and deeper layers of cerebral cortex. When we examined the amount of immunostaining of the general endo/lysosomal marker, LIMP-2, or quantified activated microglia, the higher fortnightly dose resulted in superior outcomes in affected dogs. Secondary lesions such as accumulation of GM3 ganglioside and development of GAD-reactive axonal spheroids were treated to a similar degree by both rhSGSH doses and dose frequencies. Our findings indicate that the lower fortnightly dose is sub-optimal for ameliorating existing and preventing further development of disease-related pathology in young MPS IIIA dog brain; however, increasing the dose fivefold but halving the frequency of administration enabled near normalisation of disease-related biomarkers. PMID:25421091

  17. Development of microprocessor systems

    Energy Technology Data Exchange (ETDEWEB)

    Skorupski, A.

    1983-12-01

    A classification of microprocessor systems and a presentation of world-wide trends of their development. Modular microprocessor systems and Polish achievements in this area are characterized. 8 references.

  18. Functional correction of CNS lesions in an MPS-IIIA mouse model by intracerebral AAV-mediated delivery of sulfamidase and SUMF1 genes.

    Science.gov (United States)

    Fraldi, Alessandro; Hemsley, Kim; Crawley, Allison; Lombardi, Alessia; Lau, Adeline; Sutherland, Leanne; Auricchio, Alberto; Ballabio, Andrea; Hopwood, John J

    2007-11-15

    Mucopolysaccharidosis type IIIA (MPS-IIIA or Sanfilippo syndrome) is a lysosomal storage disorder caused by the congenital deficiency of sulfamidase (SGSH) enzyme and consequent accumulation of partially degraded heparan sulfate (HS) in lysosomes. The central nervous system (CNS) is the predominant site of tissue damage in MPS-IIIA. Here we describe a gene therapy approach for MPS-IIIA in a mouse model using recombinant adeno-associated virus serotype 5 (AAV2/5) as a vehicle to deliver therapeutic genes to the CNS. SUMF1 (SUlfatase Modifying Factor 1) exhibits an enhancing effect on sulfatase activity when co-expressed with sulfatases. Consistent with these findings, we demonstrated that co-delivery of SUMF1 and SGSH (via an AAV2/5-CMV-SGSH-IRES-SUMF1 vector) resulted in a synergistic increase in SGSH activity, both in primary neural cells and in murine brain. A study aimed at testing the therapeutic efficacy of simultaneous brain administration of SUMF1 and SGSH was then performed by injecting the lateral ventricles of newborn MPS-IIIA/normal mice with either AAV2/5-CMV-SGSH-IRES-SUMF1 or AAV2/5-CMV-GFP vectors. Widespread GFP expression was observed within the GFP-injected brain, and a stable and significant increase of SGSH activity was detected in several brain regions following SGSH-IRES-SUMF1 administration. Treatment with AAV2/5-CMV-SGSH-IRES-SUMF1 vectors resulted in a visible reduction in lysosomal storage and inflammatory markers in transduced brain regions. Finally, the MPS-IIIA mice treated with therapeutic genes displayed an improvement in both motor and cognitive functions. Our results suggest that early treatment of CNS lesions by AAV-mediated intraventricular injection of both SGSH and SUMF1 genes may represent a feasible therapy for MPS-IIIA. PMID:17725987

  19. Heterologous Expression and Purification Systems for Structural Proteomics of Mammalian Membrane Proteins

    Directory of Open Access Journals (Sweden)

    Isabelle Mus-Veteau

    2006-04-01

    Full Text Available Membrane proteins (MPs are responsible for the interface between the exterior and the interior of the cell. These proteins are implicated in numerous diseases, such as cancer, cystic fibrosis, epilepsy, hyperinsulinism, heart failure, hypertension and Alzheimer's disease. However, studies on these disorders are hampered by a lack of structural information about the proteins involved. Structural analysis requires large quantities of pure and active proteins. The majority of medically and pharmaceutically relevant MPs are present in tissues at very low concentration, which makes heterologous expression in large-scale production-adapted cells a prerequisite for structural studies. Obtaining mammalian MP structural data depends on the development of methods that allow the production of large quantities of MPs. This review focuses on the different heterologous expression systems, and the purification strategies, used to produce large amounts of pure mammalian MPs for structural proteomics.

  20. Dynamic wall-shear stress measurements in turbulent pipe flow using the micro-pillar sensor MPS3

    International Nuclear Information System (INIS)

    The micro-pillar wall-shear stress sensor MPS3 has been used to measure the dynamic wall-shear stress in turbulent pipe flow. The sensor device consists of a flexible micro-pillar which extends from the wall into the viscous sublayer. The pillar-tip deflection caused by the exerting fluid forces serves as a measure for the local wall-shear stress. The pillar is statically calibrated in linear shear flow. A second-order estimate of the pillar dynamic response based on experimentally determined sensor characteristics shows the potential of the present sensor configuration to also measure the dynamic wall-shear stress. The quality of the micro-pillar shear stress sensor MPS3 to correctly determine the skin friction will be shown by measuring the wall friction in a well-defined fully developed turbulent pipe flow at Reynolds numbers Reb based on the bulk velocity Ub and the pipe diameter D in the range of Reb=10,000-20,000. The results demonstrate a convincing agreement of the mean and dynamic wall-shear stress obtained with the MPS3 sensor technique with analytical, experimental, and numerical results from the literature

  1. Development of a machine protection system for the Superconducting Beam Test Facility at Fermilab

    Energy Technology Data Exchange (ETDEWEB)

    Warner, A.; Carmichael, L.; Church, M.; Neswold, R.; /Fermilab

    2011-09-01

    Fermilab's Superconducting RF Beam Test Facility currently under construction will produce electron beams capable of damaging the acceleration structures and the beam line vacuum chambers in the event of an aberrant accelerator pulse. The accelerator is being designed with the capability to operate with up to 3000 bunches per macro-pulse, 5Hz repetition rate and 1.5 GeV beam energy. It will be able to sustain an average beam power of 72 KW at the bunch charge of 3.2 nC. Operation at full intensity will deposit enough energy in niobium material to approach the melting point of 2500 C. In the early phase with only 3 cryomodules installed the facility will be capable of generating electron beam energies of 810 MeV and an average beam power that approaches 40 KW. In either case a robust Machine Protection System (MPS) is required to mitigate effects due to such large damage potentials. This paper will describe the MPS system being developed, the system requirements and the controls issues under consideration.

  2. Condensing behavior of a freon bubble with MPS-MAFL

    International Nuclear Information System (INIS)

    In the study, MPS-MAFL is used to simulate the phenomena of a Freon bubble condensing in a subcooled pool. The sensitivity on pool subcooling is also studied to understand the condensation behavior. The simulating shows that the bubble pressure decreases as the condensation begins with the shrinking of the interface. At the later phase of the condensation, the bubble pressure becomes larger than that of the circumstance. A peak pressure will emerge at the moment that the bubble collapses and there will be a maximum pressure value at a certain subcooling. As the subcooling increases or decreases, the peak pressure will drop and may fade away. The maximum pressure is 3.12 MPa at a subcooling about 20?. (authors)

  3. Mps1 phosphorylation of condensin II controls chromosome condensation at the onset of mitosis.

    Science.gov (United States)

    Kagami, Yuya; Nihira, Keishi; Wada, Shota; Ono, Masaya; Honda, Mariko; Yoshida, Kiyotsugu

    2014-06-23

    During mitosis, genomic DNA is condensed into chromosomes to promote its equal segregation into daughter cells. Chromosome condensation occurs during cell cycle progression from G2 phase to mitosis. Failure of chromosome compaction at prophase leads to subsequent misregulation of chromosomes. However, the molecular mechanism that controls the early phase of mitotic chromosome condensation is largely unknown. Here, we show that Mps1 regulates initial chromosome condensation during mitosis. We identify condensin II as a novel Mps1-associated protein. Mps1 phosphorylates one of the condensin II subunits, CAP-H2, at Ser492 during mitosis, and this phosphorylation event is required for the proper loading of condensin II on chromatin. Depletion of Mps1 inhibits chromosomal targeting of condensin II and accurate chromosome condensation during prophase. These findings demonstrate that Mps1 governs chromosomal organization during the early stage of mitosis to facilitate proper chromosome segregation. PMID:24934155

  4. R&D ERL: Machine Protection System

    Energy Technology Data Exchange (ETDEWEB)

    Altinbas, Z.

    2010-01-01

    The Machine Protection System (MPS) is a device-safety system that is designed to prevent damage to hardware by generating interlocks, based upon the state of input signals generated by selected sub-system. It exists to protect key machinery such as the 50 kW and 1 MW RF Systems. When a fault state occurs, the MPS is capable of responding with an interlock signal within several microseconds. The Machine Protection System inputs are designed to be fail-safe. In addition, all fault conditions are latched and time-stamped. The ERL MPS is based on a National Instruments hardware platform, and is programmed by utilizing National Instruments development environment for a visual programming language.

  5. Cascade Distillation System Development

    Science.gov (United States)

    Callahan, Michael R.; Sargushingh, Miriam; Shull, Sarah

    2014-01-01

    NASA's Advanced Exploration Systems (AES) Life Support System (LSS) Project is chartered with de-veloping advanced life support systems that will ena-ble NASA human exploration beyond low Earth orbit (LEO). The goal of AES is to increase the affordabil-ity of long-duration life support missions, and to re-duce the risk associated with integrating and infusing new enabling technologies required to ensure mission success. Because of the robust nature of distillation systems, the AES LSS Project is pursuing develop-ment of the Cascade Distillation Subsystem (CDS) as part of its technology portfolio. Currently, the system is being developed into a flight forward Generation 2.0 design.

  6. OTEC ocean system development

    Science.gov (United States)

    Hove, D.; McGuinness, T.

    1981-12-01

    Ocean systems embodied in OTEC floating power plant designs include features beyond present offshore practice. Design aspects of the platform, cold water pipe and mooring systems have been investigated in Government sponsored research programs to establish a technology base for commercial plant development. Recent laboratory tests have provided validation of concepts and design tools, and future programs will include large scale demonstration tests.

  7. Evolutionary Information System Development

    DEFF Research Database (Denmark)

    Kristensen, Jan

    This paper offers advice to companies and professionals that implement e-commerce systems in business organizations. Implementing e-commerce systems is different from traditional IT implementation and thus requires a new set of tools and skills. The need for a novel approach is illustrated and necessary items that must be taken into account are pointed out by narrating two stories of e-commerce implementation processes in wholesale companies. The empirical evidence suggests the following: Managing the continued development on an operational level requires operational insight and understanding of business priorities. On a more theoretical level this suggests that we must revise our current understanding of systems development to cope.

  8. Power Systems Development Facility

    Energy Technology Data Exchange (ETDEWEB)

    Southern Company Services

    2009-01-31

    In support of technology development to utilize coal for efficient, affordable, and environmentally clean power generation, the Power Systems Development Facility (PSDF), located in Wilsonville, Alabama, has routinely demonstrated gasification technologies using various types of coals. The PSDF is an engineering scale demonstration of key features of advanced coal-fired power systems, including a Transport Gasifier, a hot gas particulate control device, advanced syngas cleanup systems, and high-pressure solids handling systems. This final report summarizes the results of the technology development work conducted at the PSDF through January 31, 2009. Twenty-one major gasification test campaigns were completed, for a total of more than 11,000 hours of gasification operation. This operational experience has led to significant advancements in gasification technologies.

  9. Random pharmacokinetic profiles of EC-MPS in children with autoimmune disease

    Directory of Open Access Journals (Sweden)

    Levy Deborah M

    2010-01-01

    Full Text Available Abstract Background Therapy with mycophenolate mofetil (MMF has become a valuable therapeutic option in children with autoimmune disease. MMF prescription in children with autoimmune diseases differs from that in transplant recipients in terms of different dosing regimen, and concomitant administration of other immunosuppressive medications. Recently, another formulation of the same active compound, mycophenolic acid (MPA, has become available as enteric-coated Mycophenolate Sodium (EC-MPS. Dosing and pharmacokinetics of EC-MPS in pediatric autoimmune disease have never been studied. Methods We therefore performed a pilot study on 6 patients, who were treated with EC-MPS. All patients underwent 1-2 full 10-point pharmacokinetic (PK profiles over a 12-hour dosing interval. We compared the results with that of 22 similar patients on MMF therapy. Results Median EC-MPS dose was 724 mg/m2 (range 179-933 mg/m2. The MPA Area-Under-The-(Time-Concentration-Curves (AUCs on MMF and EC-MPS were comparable (54.4 mg × h/L on MMF and 44.0 mg × h/L on EC-MPS, n.s., Mann Whitney. After correcting for bioequivalence, the dose-normalized AUCs were also similar on both the formulations. However, PK profiles on EC-MPS were quite random, and time to maximum concentration varied from 30 minutes to 720 minutes. The concentration at six-hour correlated best with the AUC. This was different from a homogenous PK-profile on MPA. Conclusions EC-MPS has a different PK profile from MMF. The data suggest that patients on EC-MPS must undergo a complete PK profile to assess adequate exposure. The 6-hour concentration provides an estimate of the exposure and should be targeted between 3-4 mg/L.

  10. Adaptive information system development

    OpenAIRE

    Vidgen, Richard; Wang, Xiaofeng

    2004-01-01

    Information system development (ISD) is being conducted in an increasingly turbulent and complex environment. New forms of ISD are emerging, such as open source software and agile methods but theory is needed to explain and help improve the organization of ISD. Complex Adaptive Systems (CAS) provides a novel perspective to understand and describe new forms of ISD and provide a theoretical foundation for researchers. This paper provides an overview of CAS and a review of its app...

  11. Mutagenic potential scale developed for relative evaluation of biological system response to environments presenting different gamma exposure rates

    International Nuclear Information System (INIS)

    The elaboration of a mutagenic potential scale (MPS) will be accomplished through the evaluation of the frequency of induced mutations in a plant biological system in different sites. The selection of these sites will be based on general public perception of risk to health. In this selection, it will include areas such ecological paradises and also neighborhoods of nuclear reactors and uranium mining and milling industry with potential radiological impact. The developed project foresees the contribution of other research groups that will also provide data from different sites. The referred scale will be built based on the response of the genetic system that gives color to the cells of Tradescantia (BNL 4430) stamen hair to mutagenic agents. Methodological improvements has been developed aiming the computerization of mutagenic events evaluation and statistical analysis of data that will significantly increase the efficiency of the system and obtention of results. Other biological systems of environmental quality are being added to the project, for future use. MPS should facilitate the general public and professionals of the nuclear area to understand risks, on a biological basis, of exposure from radiologically impacted environments. (author)

  12. Collaborative Library Systems Development.

    Science.gov (United States)

    Fasana, Paul J., Ed.; Veaner, Allen, Ed.

    In 1968 the National Science Foundation awarded a grant to support a project called Collaborative Library Systems Development (CLSD). Participants in the project were the libraries of the University of Chicago, Columbia University, and Stanford University. Two of the more important objectives of the CLSD Project were: 1) to test certain technical…

  13. A DSP-Based Beam Current Monitoring System for Machine Protection Using Adaptive Filtering

    International Nuclear Information System (INIS)

    The CEBAF accelerator at Jefferson Lab is currently using an analog beam current monitoring (BCM) system for its machine protection system (MPS), which has a loss accuracy of 2 micro-amps. Recent burn-through simulations predict catastrophic beam line component failures below 1 micro-amp of loss, resulting in a blind spot for the MPS. Revised MPS requirements target an ultimate beam loss accuracy of 250 nA. A new beam current monitoring system has been developed which utilizes modern digital receiver technology and digital signal processing concepts. The receiver employs a direct-digital down converter integrated circuit, mated with a Jefferson Lab digital signal processor VME card. Adaptive filtering is used to take advantage of current-dependent burn-through rates. Benefits of such a system include elimination of DC offsets, generic algorithm development, extensive filter options, and interfaces to UNIX-based control systems

  14. On the Kinematic Motion Primitives (kMPs - Theory and Application

    Directory of Open Access Journals (Sweden)

    FedericoLorenzoMoro

    2012-10-01

    Experimental tests with the COmpliant huMANoid (COMAN were performed to show that the kMPs extracted from human subjects can be used to transfer the features of human locomotion to the gait of a robot.

  15. The machine protection system for the Energy Recovery Linac

    International Nuclear Information System (INIS)

    The Machine Protection System (MPS) is a device safety system that is designed to prevent damage to hardware by generating interlocks, based upon the state of input signals generated by selected sub-systems. It protects all the key machinery in the Project called the Energy Recovery LINAC (ERL) against the high beam current. The MPS is capable of responding to a fault with an interlock signal within several microseconds. The ERL MPS is based on a National Instruments CompactRIO platform, and is programmed by utilizing National Instruments' development environment for a visual programming language. The system also transfers data (interlock status, time of fault, etc.) to the main server. Transferred data is integrated into the pre-existing software architecture which is accessible by the operators. This paper will provide an overview of the hardware used, its configuration and operation, as well as the software written both on the device and the server side. (authors)

  16. Bisphosphonate Treatment in a Patient Affected by MPS IVA with Osteoporotic Phenotype

    OpenAIRE

    Albina Tummolo; Orazio Gabrielli; Alberto Gaeta; Maristella Masciopinto; Lucia Zampini; Luigi Michele Pavone; Paola Di Natale; Francesco Papadia

    2013-01-01

    Morquio A syndrome (Mucopolysaccharidosis type IVA) (MPS IVA) is a rare inherited metabolic disorder characterized by the defective degradation of keratan sulfate and chondroitin-6-sulfate. Classically, MPS IVA patients present with severe multisystemic involvement and have a short life expectancy. Attenuated forms with clinical features limited to minor skeletal abnormalities and short stature have also been described, sometimes associated to an early-onset osteoporotic phenotype. No treatme...

  17. Diagnosis and Treatment Trends in Mucopolysaccharidosis I: Findings from the MPS I Registry

    OpenAIRE

    D’aco, Kristin; Underhill, Lisa; Rangachari, Lakshmi; Arn, Pamela; Giugliani, Roberto; Okuyama, Torayuki; Wijburg, Frits; Kaplan, Paige; Cox, Gerald Frank

    2012-01-01

    Our objective was to assess how the diagnosis and treatment of mucopolysaccharidosis I (MPS I) have changed over time. We used data from 891 patients in the MPS I Registry, an international observational database, to analyze ages at symptom onset, diagnosis, treatment initiation, and treatment allocation (hematopoietic stem cell transplantation, enzyme replacement therapy with laronidase, both, or neither) over time for all disease phenotypes (Hurler, Hurler–Scheie, and Scheie syndromes). T...

  18. A chemical tool box defines mitotic and interphase roles for Mps1 kinase

    OpenAIRE

    Lan, Weijie; Cleveland, Don W.

    2010-01-01

    In this issue, three groups (Hewitt et al. 2010. J. Cell Biol. doi:10.1083/jcb.201002133; Maciejowski et al. 2010. J. Cell Biol. doi:10.1083/jcb.201001050; Santaguida et al. 2010. J. Cell Biol. doi:10.1083/jcb.201001036) use chemical inhibitors to analyze the function of the mitotic checkpoint kinase Mps1. These studies demonstrate that Mps1 kinase activity ensures accurate chromosome segregation through its recruitment to kinetochores of mitotic checkpoint proteins, formation of interphase a...

  19. Experiments and MPS analysis of stratification behavior of two immiscible fluids

    International Nuclear Information System (INIS)

    Highlights: • Improving numerical stability of MPS method. • Implicitly calculating viscous term in momentum equation for highly viscous fluids. • Validation of the enhanced MPS method by analyzing dam break problem. • Various stratification behavior analysis by experiments and simulations. • Sensitivity analysis of the effects of the fluid viscosity and density difference. - Abstract: Stratification behavior is of great significance in the late in-vessel stage of core melt severe accident of a nuclear reactor. Conventional numerical methods have difficulties in analyzing stratification process accompanying with free surface without depending on empirical correlations. The Moving Particle Semi-implicit (MPS) method, which calculates free surface and multiphase flow without empirical equations, is applicable for analyzing the stratification behavior of fluids. In the present study, the original MPS method was improved to simulate the stratification behavior of two immiscible fluids. The improved MPS method was validated through simulating classical dam break problem. Then, the stratification processes of two fluid columns and injected fluid were investigated through experiments and simulations, using silicone oil and salt water as the simulant materials. The effects of fluid viscosity and density difference on stratification behavior were also sensitively investigated by simulations. Typical fluid configurations at various parametric and geometrical conditions were observed and well predicted by improved MPS method

  20. Numerical investigation on melt freezing behavior in a tube by MPS method

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Ronghua, E-mail: ronghuachen@aoni.waseda.jp; Oka, Yoshiaki; Li, Gen; Matsuura, Takashi

    2014-07-01

    Highlights: • The typical melt freezing behaviors were successfully reproduced by MPS method. • The predicted melt penetration lengths agree well with the experimental results. • Melt penetration dynamic was related to melt viscosity and surface tension. • MPS method is applicable to simulate the melt penetration in an instrument tube. - Abstract: Given the nuclear reactor severe accident, the instrument tubes of reactor vessel bottom head may fail and create paths through which melt could leak out of the reactor vessel wall. Thus, the melt freezing behavior in an instrument tube is a key factor that concerns the failure of the reactor pressure boundary. In this study, the moving particle semi-implicit (MPS) method was adopted to analyze the melt penetration and solidification behaviors in a tube. Both surface tension and viscosity variation with temperature were taken into account in the present MPS method. The numerical results had been compared with the downward and upward melt injection experiments, respectively. The comparative results showed that the melt leading edge position histories were in good agreement with the experimental results. The typical melt freezing behaviors were successfully reproduced by MPS method. The crust formed on the surface of the tube increased the melt flowing resistance, and would also increase the thermal resistance between the melt and the tube. Meanwhile, the melt velocity also decreased due to the increase of its viscosity. The present results indicate that MPS method is applicable to simulate the melt penetration behavior in an instrument tube.

  1. Numerical investigation on melt freezing behavior in a tube by MPS method

    International Nuclear Information System (INIS)

    Highlights: • The typical melt freezing behaviors were successfully reproduced by MPS method. • The predicted melt penetration lengths agree well with the experimental results. • Melt penetration dynamic was related to melt viscosity and surface tension. • MPS method is applicable to simulate the melt penetration in an instrument tube. - Abstract: Given the nuclear reactor severe accident, the instrument tubes of reactor vessel bottom head may fail and create paths through which melt could leak out of the reactor vessel wall. Thus, the melt freezing behavior in an instrument tube is a key factor that concerns the failure of the reactor pressure boundary. In this study, the moving particle semi-implicit (MPS) method was adopted to analyze the melt penetration and solidification behaviors in a tube. Both surface tension and viscosity variation with temperature were taken into account in the present MPS method. The numerical results had been compared with the downward and upward melt injection experiments, respectively. The comparative results showed that the melt leading edge position histories were in good agreement with the experimental results. The typical melt freezing behaviors were successfully reproduced by MPS method. The crust formed on the surface of the tube increased the melt flowing resistance, and would also increase the thermal resistance between the melt and the tube. Meanwhile, the melt velocity also decreased due to the increase of its viscosity. The present results indicate that MPS method is applicable to simulate the melt penetration behavior in an instrument tube

  2. Sepsis and development impede muscle protein synthesis in neonatal pigs by different ribosomal mechanisms

    Science.gov (United States)

    In muscle, sepsis reduces protein synthesis (MPS) by restraining translation in neonates and adults. Even though protein accretion decreases with development as neonatal MPS rapidly declines by maturation, the changes imposed by development on the sepsis-associated decrease in MPS have not been desc...

  3. Myocardial Perfusion Tomoscintigraphy With 99mTc MIBI (SPECT MPS 99mTc MIBI) In The Assessment Of Myocardial Viability

    International Nuclear Information System (INIS)

    Prognosis of the patients with severe coronary artery disease is highly dependent on the degree of left ventricular dysfunction. Impaired contractile performance at rest is not necessarily due to Irreversible tissue damage but may relate to the 'hibernating' myocardium which has been defined as potentially reversible, chronic contractile dysfunction during prolonged, painless ischemia. Recovery of function may occur after successful revascularization only in the presence of substantial amount of viable myocardium. The development of highly precise and predictable diagnostic methods for the identification of viable myocardium and postoperative functional improvement is crucial for reasonable preoperative selection of the patients. Detection of hibernated myocardium Is a real diagnostic challenge when FDG-Fl8 PET, as the most accurate method for myocardial viability assessment is not available and Tl 201, as already established myocardial viability marker is not routinely used. Interest for the 99mTc labeled complexes, most often 99mTc MIBI, as proved myocardial perfusion but not yet viability tracer is constantly increasing, supported by the widespread availability of this radioisotope, its better imaging and radio dosimetric properties when compared to Ti 201. The aim of this study was to evaluate the diagnostic value of different SPECT MIBI Tc99m myocardial perfusion scintigraphy (MPS) modalities performed at rest and after nitrate administration, in the detection ofitrate administration, in the detection of myocardial viability (MV) arid to compare it with rest-redistribution TI 201 MPS (R-Red) and with the control SPECT MPS Tc99m MIBI study after revascularization. In a prospective study, 176 patients (34-77yrs, 25 female, 151 male), with angiographically proved coronary artery disease, most of them with previous myocardial infarction (143/176p (81%),>6 months) and LV dysfunction (110/176p (62%), EFG-MPS 41+/-16%) underwent ECG Gated SPECT MPS Tc 99m MIBI at rest and after s.l. administration of 0,5 mg Nitroglycerin (NTG). 20/176 p were examined also by TI 201 R-Red study and 20/176p were reevaluated after revascularization. Qualitative and quantitative analysis of rest, post-NTG and TI 201 Rest-Redistribution perfusion images (QL,QN) and functional analysis of rest and post-NTG Gated study (G) was done, using 17 segment model, grouped also according to vascular territories and 5-point scoring system for assessment of perfusion (0-normal, 1-mild,2-moderate,3-severe hypoperfusion, 4-absent perfusion) and wall motion (0-normal,l-mild,2-severe hypo kinetic, 3-akinetic,4-dyskinetic). A segment was predeterminated to be viable if the segment score was ?2 by perfusion (>50% photon activity by circumferential profiles) and ?2 by C-CG qated SPECT analysis (wall motion +/-, wall thickening-). Summed segment viability scores, total and separate for particular territory were. calculated and used to predict overall and territory viability. In a group of 176 pts, from a total of 2992 analyzed myocardial segments, 47% were nonviable by QL-Rest analysis, 31% by QN-Rest (p2) 25% by G-Rest (p2), 36% by QL-Rest-Red (p=0.3 vs. QL-Rest, ?2), 18% by QN-Rest-Red (p=04 vs. QN-Rest, ?2),), 33% by QL-NTG (p2), 19% by QN-NTG (p2), 16% by G-NTG (p=0.08 vs. QN-NTG, ?2), 28% by QL-NTG-Red (P=0.33 vs. QL-NTG, ?2), and 17% by QN-NTG-Red (p=0.4 vs. QN- NTG, ?2). Similar relation among different modalities was also observed during the assessment of total viability score: 26+/-9.1 by QN-Rest, 21.8+/-8.9 by G-Rest (p<0.01 vs. QN-Rest), 20.2+/-9.9 by QN-NTG (p<0.0l vs. G-Rest) and 16.7+/-9.4 by NTG-G (p<0.001 vs QN-NTG). Compared with TI 201 R-Red the sensitivity, specificity, positive and negative predictive values and accuracy for SPECT MPS Tc99m MIBI modalities were: 73%,100%,100%,37,5%,76% for QL-Rest, 84%,96%,99%,49%,86% for QN-Rest, 93,5%,81%,97%,67% 92% for G-Rest, 86%,94%, 99%,52%,87% for QL-NTG, 97%,90%,98%,81%,96% for QN-NTG and 97%,75%,96%82%,94% for G-NTG. Compared with the study after revascularization the sensitivity, specificity,

  4. Geological disposal system development

    International Nuclear Information System (INIS)

    Spent fuel inventories to be disposed of finally and design base spent fuel were determined. Technical and safety criteria for a geological repository system in Korea were established. Based on the properties of spent PWR and CANDU fuels, seven repository alternatives were developed and the most promising repository option was selected by the pair-wise comparison method from the technology point of view. With this option preliminary conceptual design studies were carried out. Several module, e.g., gap module, congruent release module were developed for the overall assessment code MASCOT-K. The prominent overseas databases such as OECD/NEA FEP list were are fully reviewed and then screened to identify the feasible ones to reflect the Korean geo-hydrological conditions. In addition to this the well known scenario development methods such as PID, RES were reviewed. To confirm the radiological safety of the proposed KAERI repository concept the preliminary PA was pursued. Thermo-hydro-mechanical analysis for the near field of repository were performed to verify thermal and mechanical stability for KAERI repository system. The requirements of buffer material were analyzed, and based on the results, the quantitative functional criteria for buffer material were established. The hydraulic and swelling property, mechanical properties, and thermal conductivity, the organic carbon content, and the evolution of pore water chemistry were investigated. Based on the results, the candidate buffer material was selected

  5. CheMPS2: a free open-source spin-adapted implementation of the density matrix renormalization group for ab initio quantum chemistry

    CERN Document Server

    Wouters, Sebastian; Ayers, Paul W; Van Neck, Dimitri

    2013-01-01

    The density matrix renormalization group (DMRG) has become an indispensable numerical tool to find exact eigenstates of finite-size quantum systems with strong correlation. In the fields of condensed matter, nuclear structure and molecular electronic structure, it has significantly extended the system sizes that can be handled compared to full configuration interaction, without losing numerical accuracy. For quantum chemistry (QC), the most efficient implementations of DMRG require the incorporation of particle number, spin and point group symmetries in the underlying matrix product state (MPS) ansatz, as well as the use of so-called complementary operators. The symmetries introduce a sparse block structure in the MPS ansatz and in the intermediary contracted tensors. If a symmetry is non-abelian, the Wigner-Eckart theorem allows to factorize a tensor into a Clebsch-Gordan coefficient and a reduced tensor. In addition, the fermion signs have to be carefully tracked. Because of these challenges, implementing D...

  6. Numerical analysis of crust formation in molten core-concrete interaction using MPS method

    International Nuclear Information System (INIS)

    A two-dimensional code is developed for molten core-concrete interaction (MCCI) based on Moving Particle Semi-implicit (MPS) method. Heat transfer is calculated without any specific correlations. A particle can be changed to a moving (fluid) or fixed (solid) particle corresponding to its enthalpy, which provide the phase change model for particles. The phase change model is verified by one-dimensional test calculations. Nucleate boiling and radiation heat transfers are considered between the core debris and the water pool. The developed code is applied to SWISS-2 experiment in which stainless steel is used as the melt material. Calculated heat flux to the water pool agrees well with the experiment, though the ablation speed in the concrete is a little slower. A stable crust is formed in a short time after water is poured in and the heat flux to the water pool rapidly decreases. MACE-M0 using corium is also analyzed. The ablation speed of concrete is slower than that of SWISS-2 because of low heat conduction in corium. An unlimited geometry is analyzed by setting the cyclic boundary condition on the sides. When the crust is broken by the decomposition gas, heat transfer to the water pool is kept high for a longer time because the crust re-formation is delayed. (author)

  7. Numerical analysis of crust formation in molten core-concrete interaction using MPS method

    Energy Technology Data Exchange (ETDEWEB)

    Seiichi, Koshizuka; Shoji, Matsuura; Mizue, Sekine; Yoshiaki, Oka [Tokyo Univ., Tokai, Ibaraki (Japan). Nuclear Engineering Research Lab.; Hiroyuki, Obata [Japan Atomic Power Co., Tokyo (Japan)

    2001-07-01

    A two-dimensional code is developed for molten core-concrete interaction (MCCI) based on Moving Particle Semi-implicit (MPS) method. Heat transfer is calculated without any specific correlations. A particle can be changed to a moving (fluid) or fixed (solid) particle corresponding to its enthalpy, which provide the phase change model for particles. The phase change model is verified by one-dimensional test calculations. Nucleate boiling and radiation heat transfers are considered between the core debris and the water pool. The developed code is applied to SWISS-2 experiment in which stainless steel is used as the melt material. Calculated heat flux to the water pool agrees well with the experiment, though the ablation speed in the concrete is a little slower. A stable crust is formed in a short time after water is poured in and the heat flux to the water pool rapidly decreases. MACE-M0 using corium is also analyzed. The ablation speed of concrete is slower than that of SWISS-2 because of low heat conduction in corium. An unlimited geometry is analyzed by setting the cyclic boundary condition on the sides. When the crust is broken by the decomposition gas, heat transfer to the water pool is kept high for a longer time because the crust re-formation is delayed. (author)

  8. Advanced Dewatering Systems Development

    Energy Technology Data Exchange (ETDEWEB)

    R.H. Yoon; G.H. Luttrell

    2008-07-31

    A new fine coal dewatering technology has been developed and tested in the present work. The work was funded by the Solid Fuels and Feedstocks Grand Challenge PRDA. The objective of this program was to 'develop innovative technical approaches to ensure a continued supply of environmentally sound solid fuels for existing and future combustion systems with minimal incremental fuel cost.' Specifically, this solicitation is aimed at developing technologies that can (i) improve the efficiency or economics of the recovery of carbon when beneficiating fine coal from both current production and existing coal slurry impoundments and (ii) assist in the greater utilization of coal fines by improving the handling characteristics of fine coal via dewatering and/or reconstitution. The results of the test work conducted during Phase I of the current project demonstrated that the new dewatering technologies can substantially reduce the moisture from fine coal, while the test work conducted during Phase II successfully demonstrated the commercial viability of this technology. It is believed that availability of such efficient and affordable dewatering technology is essential to meeting the DOE's objectives.

  9. The machine protection system for the R and D energy recovery LINAC

    International Nuclear Information System (INIS)

    The Machine Protection System (MPS) is a device-safety system that is designed to prevent damage to hardware by generating interlocks, based upon the state of input signals generated by selected sub-systems. It protects all the key machinery in the R and D Project called the Energy Recovery LINAC (ERL) against the high beam current. The MPS is capable of responding to a fault with an interlock signal within several microseconds. The ERL MPS is based on a National Instruments CompactRIO platform, and is programmed by utilizing National Instruments' development environment for a visual programming language. The system also transfers data (interlock status, time of fault, etc.) to the main server. Transferred data is integrated into the pre-existing software architecture which is accessible by the operators. This paper will provide an overview of the hardware used, its configuration and operation, as well as the software written both on the device and the server side.

  10. The machine protection system for the R&D energy recovery LINAC

    Energy Technology Data Exchange (ETDEWEB)

    Altinbas, Z.; Kayran, D.; Jamilkowski, J.; Lee, R.C.; Oerter, B.

    2011-03-28

    The Machine Protection System (MPS) is a device-safety system that is designed to prevent damage to hardware by generating interlocks, based upon the state of input signals generated by selected sub-systems. It protects all the key machinery in the R&D Project called the Energy Recovery LINAC (ERL) against the high beam current. The MPS is capable of responding to a fault with an interlock signal within several microseconds. The ERL MPS is based on a National Instruments CompactRIO platform, and is programmed by utilizing National Instruments' development environment for a visual programming language. The system also transfers data (interlock status, time of fault, etc.) to the main server. Transferred data is integrated into the pre-existing software architecture which is accessible by the operators. This paper will provide an overview of the hardware used, its configuration and operation, as well as the software written both on the device and the server side.

  11. Power Systems Development Facility

    International Nuclear Information System (INIS)

    The objective of the PSDF would be to provide a modular facility which would support the development of advanced, pilot-scale, coal-based power systems and hot gas clean-up components. These pilot-scale components would be designed to be large enough so that the results can be related and projected to commercial systems. The facility would use a modular approach to enhance the flexibility and capability for testing; consequently, overall capital and operating costs when compared with stand-alone facilities would be reduced by sharing resources common to different modules. The facility would identify and resolve technical barrier, as well as-provide a structure for long-term testing and performance assessment. It is also intended that the facility would evaluate the operational and performance characteristics of the advanced power systems with both bituminous and subbituminous coals. Five technology-based experimental modules are proposed for the PSDF: (1) an advanced gasifier module, (2) a fuel cell test module, (3) a PFBC module, (4) a combustion gas turbine module, and (5) a module comprised of five hot gas cleanup particulate control devices. The final module, the PCD, would capture coal-derived ash and particles from both the PFBC and advanced gasifier gas streams to provide for overall particulate emission control, as well as to protect the combustion turbine and the fuel cell

  12. Power Systems Development Facility

    Energy Technology Data Exchange (ETDEWEB)

    None

    2003-07-01

    This report discusses Test Campaign TC12 of the Kellogg Brown & Root, Inc. (KBR) Transport Gasifier train with a Siemens Westinghouse Power Corporation (SW) particle filter system at the Power Systems Development Facility (PSDF) located in Wilsonville, Alabama. The Transport Gasifier is an advanced circulating fluidized-bed reactor designed to operate as either a combustor or a gasifier using a particulate control device (PCD). While operating as a gasifier, either air or oxygen can be used as the oxidant. Test run TC12 began on May 16, 2003, with the startup of the main air compressor and the lighting of the gasifier start-up burner. The Transport Gasifier operated until May 24, 2003, when a scheduled outage occurred to allow maintenance crews to install the fuel cell test unit and modify the gas clean-up system. On June 18, 2003, the test run resumed when operations relit the start-up burner, and testing continued until the scheduled end of the run on July 14, 2003. TC12 had a total of 733 hours using Powder River Basin (PRB) subbituminous coal. Over the course of the entire test run, gasifier temperatures varied between 1,675 and 1,850 F at pressures from 130 to 210 psig.

  13. Bone marrow transplantation in patients with storage diseases: a developing country experience

    Directory of Open Access Journals (Sweden)

    Lange Marcos C.

    2006-01-01

    Full Text Available Bone marrow transplantation (BMT is a therapeutic option for patients with genetic storage diseases. Between 1979 and 2002, eight patients, four females and four males (1 to 13 years old were submitted to this procedure in our center. Six patients had mucopolysaccharidosis (MPS I in 3; MPS III in one and MPS VI in 2, one had adrenoleukodystrophy (ALD and one had Gaucher disease. Five patients had related and three unrelated BMT donor. Three patients developed graft versus host disease (two MPS I and one MPS VI and died between 37 and 151 days after transplantation. Five patients survived 4 to 16 years after transplantation. Three patients improved (one MPS I; one MPS VI and the Gaucher disease patient, one patient had no disease progression (ALD and in one patient this procedure did not change the natural course of the disease (MPS III.

  14. Public Integrity and New Rules of Conduct for Romanian MPs: A Romanian Case Study

    Directory of Open Access Journals (Sweden)

    Cynthia Carmen CURT

    2013-11-01

    Full Text Available The article refers to the problem of incompatibilities and conflicts of interests of public officials in the Romanian society and its severe consequences upon the fulfillment of the conditions of the European Commission Verification and Cooperation Mechanism’s benchmarks by Romania. The present study proposes a critical analysis of recent legislative changes of the rules of conduct for MPs in Romania, relatively to the regime of incompatibilities and conflicts of interests, emphasizing the manner in which the Parliament constantly tries to limit the prerogatives of the National Integrity Agency (NIA. Special attention is paid to the analysis of incompatibilities applicable to the MPs who are simultaneously Government members. The study follows several steps: an introduction, a critical analysis of the new legislation, focusing on the new rules of conduct for MPs, an analysis of the most important case studies and conclusions. The introduction describes the problem of incompatibilities and conflicts of interest of MPs and members of Government reflected in the recent CVM Report and the position of the National Integrity Agency. The analysis of the legislation presents a critical evaluation of the new rules of conduct for MPs, adopted in 2013 by the Romanian Parliament; then, analyzing the most important and recent case studies, general patterns in the field of procedures of incompatibilities and conflicts of interests emerge. Conclusions propose legislative solutions in terms of raising the standards of public integrity.

  15. Power Systems Development Facility

    Energy Technology Data Exchange (ETDEWEB)

    Southern Company Services

    2004-04-30

    This report discusses Test Campaign TC15 of the Kellogg Brown & Root, Inc. (KBR) Transport Gasifier train with a Siemens Power Generation, Inc. (SPG) particle filter system at the Power Systems Development Facility (PSDF) located in Wilsonville, Alabama. The Transport Gasifier is an advanced circulating fluidized-bed reactor designed to operate as either a combustor or gasifier using a particulate control device (PCD). While operating as a gasifier, either air or oxygen can be used as the oxidant. Test run TC15 began on April 19, 2004, with the startup of the main air compressor and the lighting of the gasifier startup burner. The Transport Gasifier was shutdown on April 29, 2004, accumulating 200 hours of operation using Powder River Basin (PRB) subbituminous coal. About 91 hours of the test run occurred during oxygen-blown operations. Another 6 hours of the test run was in enriched-air mode. The remainder of the test run, approximately 103 hours, took place during air-blown operations. The highest operating temperature in the gasifier mixing zone mostly varied from 1,800 to 1,850 F. The gasifier exit pressure ran between 200 and 230 psig during air-blown operations and between 110 and 150 psig in oxygen-enhanced air operations.

  16. POWER SYSTEMS DEVELOPMENT FACILITY

    Energy Technology Data Exchange (ETDEWEB)

    Unknown

    2002-11-01

    This report discusses test campaign GCT4 of the Kellogg Brown & Root, Inc. (KBR) transport reactor train with a Siemens Westinghouse Power Corporation (Siemens Westinghouse) particle filter system at the Power Systems Development Facility (PSDF) located in Wilsonville, Alabama. The transport reactor is an advanced circulating fluidized-bed reactor designed to operate as either a combustor or a gasifier using one of two possible particulate control devices (PCDs). The transport reactor was operated as a pressurized gasifier during GCT4. GCT4 was planned as a 250-hour test run to continue characterization of the transport reactor using a blend of several Powder River Basin (PRB) coals and Bucyrus limestone from Ohio. The primary test objectives were: Operational Stability--Characterize reactor loop and PCD operations with short-term tests by varying coal-feed rate, air/coal ratio, riser velocity, solids-circulation rate, system pressure, and air distribution. Secondary objectives included the following: Reactor Operations--Study the devolatilization and tar cracking effects from transient conditions during transition from start-up burner to coal. Evaluate the effect of process operations on heat release, heat transfer, and accelerated fuel particle heat-up rates. Study the effect of changes in reactor conditions on transient temperature profiles, pressure balance, and product gas composition. Effects of Reactor Conditions on Synthesis Gas Composition--Evaluate the effect of air distribution, steam/coal ratio, solids-circulation rate, and reactor temperature on CO/CO{sub 2} ratio, synthesis gas Lower Heating Value (LHV), carbon conversion, and cold and hot gas efficiencies. Research Triangle Institute (RTI) Direct Sulfur Recovery Process (DSRP) Testing--Provide syngas in support of the DSRP commissioning. Loop Seal Operations--Optimize loop seal operations and investigate increases to previously achieved maximum solids-circulation rate.

  17. Heparin cofactor II-thrombin complex: a biomarker of MPS disease.

    Science.gov (United States)

    Randall, Derrick R; Colobong, Karen E; Hemmelgarn, Harmony; Sinclair, Graham B; Hetty, Elly; Thomas, Anita; Bodamer, Olaf A; Volkmar, Barbara; Fernhoff, Paul M; Casey, Robin; Chan, Alicia K; Mitchell, Grant; Stockler, Silvia; Melancon, Serge; Rupar, Tony; Clarke, Lorne A

    2008-08-01

    The mucopolysaccharidoses are a group of lysosomal storage disorders caused by defects in the degradation of glycosaminoglycans. Each disorder is characterized by progressive multi-system disease with considerable clinical heterogeneity. The clinical heterogeneity of these disorders is thought to be related to the degree of the metabolic block in glycosaminoglycan degradation which in turn is related to the underlying mutation at the respective locus. There are currently no objective means other than longitudinal clinical observation, or the detection of a recurrent genetic mutation to accurately predict the clinical course for an individual patient, particularly when diagnosed early. In addition, there are no specific disease biomarkers that reflect the total body burden of disease. The lack of specific biomarkers has made monitoring treatment responses and predicting disease course difficult in these disorders. The recent introduction of enzyme replacement therapy for MPS I, II, and VI highlights the need for objective measures of disease burden and disease responsiveness. We show that serum levels of heparin cofactor II-thrombin complex is a reliable biomarker of the mucopolysaccharidoses. Untreated patients have serum levels that range from 3- to 112-fold above control values. In a series of patients with varying severity of mucopolysaccharidosis I, the serum complex concentration was reflective of disease severity. In addition, serum heparin cofactor II-thrombin levels showed responsiveness to various treatment regimens. We propose that serum levels of heparin cofactor II-thrombin complex may provide an important assessment and monitoring tool for patients with mucopolysaccharidosis. PMID:18511319

  18. CheMPS2: A free open-source spin-adapted implementation of the density matrix renormalization group for ab initio quantum chemistry

    Science.gov (United States)

    Wouters, Sebastian; Poelmans, Ward; Ayers, Paul W.; Van Neck, Dimitri

    2014-06-01

    The density matrix renormalization group (DMRG) has become an indispensable numerical tool to find exact eigenstates of finite-size quantum systems with strong correlation. In the fields of condensed matter, nuclear structure and molecular electronic structure, it has significantly extended the system sizes that can be handled compared to full configuration interaction, without losing numerical accuracy. For quantum chemistry (QC), the most efficient implementations of DMRG require the incorporation of particle number, spin and point group symmetries in the underlying matrix product state (MPS) ansatz, as well as the use of so-called complementary operators. The symmetries introduce a sparse block structure in the MPS ansatz and in the intermediary contracted tensors. If a symmetry is non-abelian, the Wigner-Eckart theorem allows to factorize a tensor into a Clebsch-Gordan coefficient and a reduced tensor. In addition, the fermion signs have to be carefully tracked. Because of these challenges, implementing DMRG efficiently for QC is not straightforward. Efficient and freely available implementations are therefore highly desired. In this work we present CheMPS2, our free open-source spin-adapted implementation of DMRG for ab initio QC. Around CheMPS2, we have implemented the augmented Hessian Newton-Raphson complete active space self-consistent field method, with exact Hessian. The bond dissociation curves of the 12 lowest states of the carbon dimer were obtained at the DMRG(28 orbitals, 12 electrons, DSU(2)=2500)/cc-pVDZ level of theory. The contribution of 1s core correlation to the X1?g+ bond dissociation curve of the carbon dimer was estimated by comparing energies at the DMRG(36o, 12e, DSU(2)=2500)/cc-pCVDZ and DMRG-SCF(34o, 8e, DSU(2)=2500)/cc-pCVDZ levels of theory.

  19. Enzyme replacement therapy for Mucopolysaccharidosis Type I among patients followed within the MPS Brazil Network

    OpenAIRE

    Dornelles, Ali?cia Dorneles; Camargo Pinto, Louise Lapagesse; Paula, Ana Carolina; Steiner, Carlos Eduardo; Lourenc?o, Charles Marques; Kim, Chong Ae; Horovitz, Dafne Dain Gandelman; Ribeiro, Erlane Marques; Valadares, Euge?nia Ribeiro; Goulart, Isabela; Neves Souza, Isabel C.; Da Costa Neri, Joa?o Ivanildo; Santana-da-silva, Luiz Carlos; Silva, Luiz Roberto; Ribeiro, Ma?rcia

    2013-01-01

    Mucopolysaccharidosis type I (MPS I) is a rare lysosomal disorder caused by deficiency of alpha-L-iduronidase. Few clinical trials have assessed the effect of enzyme replacement therapy (ERT) for this condition. We conducted an exploratory, open-label, non-randomized, multicenter cohort study of patients with MPS I. Data were collected from questionnaires completed by attending physicians at the time of diagnosis (T1; n = 34) and at a median time of 2.5 years later (T2; n = 24/34). The 24 pat...

  20. Numerical analysis of bubble rising behavior in a liquid metal using MPS

    International Nuclear Information System (INIS)

    Moving Particle Semi-Implicit (MPS) Method has advantages over the traditional mesh-based methods in the accurate capture of the vapor-liquid interface. In the present study, the numerical simulation of single bubble rising behavior in the liquid Pb-Bi alloy had been performed. The numerical results are provided for bubble shape deformation and rising velocity. Numerical simulation results indicate that as the bubble rises, the bubble exhibits in turn spherical, dimpled ellipsoidal, spherical-cap shapes. Terminal velocity of the bubble predicted by MPS agrees well with that predicted by Grace and increases with the initial bubble diameter. (authors)

  1. Numerical simulation of sloshing with large deforming free surface by MPS-LES method

    Science.gov (United States)

    Pan, Xu-jie; Zhang, Huai-xin; Sun, Xue-yao

    2012-12-01

    Moving particle semi-implicit (MPS) method is a fully Lagrangian particle method which can easily solve problems with violent free surface. Although it has demonstrated its advantage in ocean engineering applications, it still has some defects to be improved. In this paper, MPS method is extended to the large eddy simulation (LES) by coupling with a sub-particle-scale (SPS) turbulence model. The SPS turbulence model turns into the Reynolds stress terms in the filtered momentum equation, and the Smagorinsky model is introduced to describe the Reynolds stress terms. Although MPS method has the advantage in the simulation of the free surface flow, a lot of non-free surface particles are treated as free surface particles in the original MPS model. In this paper, we use a new free surface tracing method and the key point is "neighbor particle". In this new method, the zone around each particle is divided into eight parts, and the particle will be treated as a free surface particle as long as there are no "neighbor particles" in any two parts of the zone. As the number density parameter judging method has a high efficiency for the free surface particles tracing, we combine it with the neighbor detected method. First, we select out the particles which may be mistreated with high probabilities by using the number density parameter judging method. And then we deal with these particles with the neighbor detected method. By doing this, the new mixed free surface tracing method can reduce the mistreatment problem efficiently. The serious pressure fluctuation is an obvious defect in MPS method, and therefore an area-time average technique is used in this paper to remove the pressure fluctuation with a quite good result. With these improvements, the modified MPS-LES method is applied to simulate liquid sloshing problems with large deforming free surface. Results show that the modified MPS-LES method can simulate the large deforming free surface easily. It can not only capture the large impact pressure accurately on rolling tank wall but also can generate all physical phenomena successfully. The good agreement between numerical and experimental results proves that the modified MPS-LES method is a good CFD methodology in free surface flow simulations.

  2. Accelerator protection system of the MR division of J-PARC using embedded EPICS

    International Nuclear Information System (INIS)

    J-PARC is the large intensity accelerator. The strong radioactivation is caused, since the energy is comparatively high, when the accelerated particle collides with vacuum duct and equipment. The problem of producing degradation and trouble of the equipment, and the maintenance becoming impossible is caused. Then, machine protection system (MPS) which stopped the beam acceleration in the abnormal case of the equipment was developed. In LINAC/RCS and MR, it was independently developed, since the arrangement of the electric power source equipment is different. However, the operation which was united as an MPS has been done by unifying the connection specification of the signal. On MPS equipment used in the MR division, it explains on specification of the equipment, positioning of EPICS, operation situations, etc. (author)

  3. Systems biology approach to developing "systems therapeutics".

    Science.gov (United States)

    Maguire, Greg

    2014-05-01

    The standard drug development model uses reductionist approaches to discover small molecules targeting one pathway. Although systems biology analyzes multiple pathways, the approach is often used to develop a small molecule interacting at only one pathway in the system. Similar to that in physics where a departure from the old reductionist "Copenhagen View" of quantum physics to a new and predictive systems based, collective model has emerged yielding new breakthroughs such as the LASER, a new model is emerging in biology where systems biology is used to develop a new technology acting at multiple pathways called "systems therapeutics." PMID:24900858

  4. Numerical analysis of isothermal JET injection into a denser liquid pool using RD-MPS Method

    International Nuclear Information System (INIS)

    In this study, the rigid body dynamics coupled moving particle semi-implicit (RD-MPS) method was used to simulate a plunging liquid jet penetrating into a denser liquid pool. The phenomenon is related to fuel-coolant interactions (FCI) during severe accidents in nuclear power plants when coolant water is forcedly injected into a melt pool. A numerical particle method like MPS enables to simulate the complex multiphase flow in that significant deformation of fluids occurs due to its inherent grid less algorithm. However, the MPS method alone cannot continue the calculation for a long time as shown in the Ikea's work due to the large deformation of fluid surfaces and the difference in both liquid densities. In the RD-MPS method, the rigid body dynamics was coupled with the moving particle semi-implicit method to increase the overall stability of calculations and to calculate the multi-phase behavior of fluids. We performed two and three dimensional calculations to simulate jet penetration behaviors in a denser liquid pool, and the result was in good agreement with that of experiment. The simulation results suggested that the coupled model be useful in simulating dynamic interactions of multi-phase incompressible fluids as well as that the 3-D simulation for the plunging jet in a confined geometry predicted better agreement with experimental results than the 2-D simulation did

  5. Framework for control system development

    International Nuclear Information System (INIS)

    Control systems being developed for the present generation of accelerators will need to adapt to changing machine and operating state conditions. Such systems must also be capable of evolving over the life of the accelerator operation. In this paper we present a framework for the development of adaptive control systems

  6. Reforming when MPs work is not about making their lives easier, but ensuring the most effective balance between constituency and Parliamentary time

    OpenAIRE

    Childs, Sarah; Malley, Rosa

    2011-01-01

    With outrage over the parliamentary expenses scandal and public respect for MPs lower than ever, any discussion of MPs working less hours can be spun as yet another example of ‘work-shy’ MPs. But this is not the case argue Sarah Childs and Rosa Malley, who here examine the importance of reforming how MPs’ time is balanced between constituency and Parliamentary business, how time in parliament might be reformed, and how this may make the House a more diverse place.

  7. The Guided System Development Framework

    DEFF Research Database (Denmark)

    Carvalho Quaresma, Jose Nuno; Probst, Christian W.

    2011-01-01

    The Service-Oriented Computing paradigm has had significant influence on the Internet. With the emergence of this paradigm, it is important to provide tools that help developers designing and verifying such systems. In this article, we present the Guided System Development (GSD) Framework that aids and guides the developer on the specification of the system being developed, on choosing the appropriate standard protocols suites that achieve the required security properties, on providing an implementation of the specified system, and also on allowing the verification of its security properties.

  8. Liferay Portal Systems Development

    CERN Document Server

    Yuan, Jonas X

    2012-01-01

    This book focuses on teaching by example. Every chapter provides an overview, and then dives right into hands-on examples so you can see and play with the solution in your own environment. This book is for Java developers who don't need any prior experience with Liferay portal. Although Liferay portal makes heavy use of open source frameworks, no prior experience of using these is assumed.

  9. Development of FAME Animation System

    Energy Technology Data Exchange (ETDEWEB)

    Hasegawa, Yukihiro; Hamamatsu, Kiyotaka; Shirai, Hiroshi; Matsuda, Toshiaki [Department of Fusion Plasma Research, Naka Fusion Research Establishment, Japan Atomic Energy Research Institute, Naka, Ibaraki (Japan); Watanabe, Hideto; Itakura, Hirofumi; Tahata, Yasunori

    1999-02-01

    In order to monitor an animation of magnetohydrodynamic equilibrium calculated by the FAME-II (Fast Analyzer for Magnetohydrodynamic Equilibrium-II) system, a FAME Animation System was developed. This system provides automatically the animation on workstations connected to network with the same period of JT-60U discharge sequence. Then, the system can supply the important information for JT-60U operators to determine control parameters of the succeeding discharge. This report describes the overview of the FAME Animation System. (author)

  10. ISE System Development Methodology Manual

    Energy Technology Data Exchange (ETDEWEB)

    Hayhoe, G.F.

    1992-02-17

    The Information Systems Engineering (ISE) System Development Methodology Manual (SDM) is a framework of life cycle management guidelines that provide ISE personnel with direction, organization, consistency, and improved communication when developing and maintaining systems. These guide-lines were designed to allow ISE to build and deliver Total Quality products, and to meet the goals and requirements of the US Department of Energy (DOE), Westinghouse Savannah River Company, and Westinghouse Electric Corporation.

  11. HLW Disposal System Development

    International Nuclear Information System (INIS)

    A KRS is suggested through design requirement analysis of the buffer and the canister which are the constituent of disposal system engineered barrier and HLW management plans are proposed. In the aspect of radionuclide retention capacity, the thickness of the buffer is determined 0.5m, the shape to be disc and ring and the dry density to be 1.6 g/cm3. The maximum temperature of the buffer is below 100 .deg. which meets the design requirement. And bentonite blocks with 5 wt% of graphite showed more than 1.0 W/mK of thermal conductivity without the addition of sand. The result of the thermal analysis for proposed double-layered buffer shows that decrease of 7 .deg. C in maximum temperature of the buffer. For the disposal canister, the copper for the outer shell material and cast iron for the inner structure material is recommended considering the results analyzed in terms of performance of the canisters and manufacturability and the geochemical properties of deep groundwater sampled from the research area with granite, salt water intrusion, and the heavy weight of the canister. The results of safety analysis for the canister shows that the criticality for the normal case including uncertainty is the value of 0.816 which meets subcritical condition. Considering nation's 'Basic Plan for Electric Power Demand and Supply' and based on the scenario of disposing CANDU spent fuels in the first phase, the disposal system that the repository will be excavated in eight phases with the construction of the Underground Research Laboratory (URL) beginning in 2020 and commissioning in 2040 until the closure of the repository is proposed. Since there is close correlation between domestic HLW management plans and front-end/back-end fuel cycle plans causing such a great sensitivity of international environment factor, items related to assuring the non-proliferation and observing the international standard are showed to be the influential factor and acceptability of HLW management plans to be the influential factor of making decision for social acceptability of nuclear power

  12. HLW Disposal System Development

    Energy Technology Data Exchange (ETDEWEB)

    Choi, J. W.; Choi, H. J.; Lee, J. Y. (and others)

    2007-06-15

    A KRS is suggested through design requirement analysis of the buffer and the canister which are the constituent of disposal system engineered barrier and HLW management plans are proposed. In the aspect of radionuclide retention capacity, the thickness of the buffer is determined 0.5m, the shape to be disc and ring and the dry density to be 1.6 g/cm{sup 3}. The maximum temperature of the buffer is below 100 .deg. which meets the design requirement. And bentonite blocks with 5 wt% of graphite showed more than 1.0 W/mK of thermal conductivity without the addition of sand. The result of the thermal analysis for proposed double-layered buffer shows that decrease of 7 .deg. C in maximum temperature of the buffer. For the disposal canister, the copper for the outer shell material and cast iron for the inner structure material is recommended considering the results analyzed in terms of performance of the canisters and manufacturability and the geochemical properties of deep groundwater sampled from the research area with granite, salt water intrusion, and the heavy weight of the canister. The results of safety analysis for the canister shows that the criticality for the normal case including uncertainty is the value of 0.816 which meets subcritical condition. Considering nation's 'Basic Plan for Electric Power Demand and Supply' and based on the scenario of disposing CANDU spent fuels in the first phase, the disposal system that the repository will be excavated in eight phases with the construction of the Underground Research Laboratory (URL) beginning in 2020 and commissioning in 2040 until the closure of the repository is proposed. Since there is close correlation between domestic HLW management plans and front-end/back-end fuel cycle plans causing such a great sensitivity of international environment factor, items related to assuring the non-proliferation and observing the international standard are showed to be the influential factor and acceptability of HLW management plans to be the influential factor of making decision for social acceptability of nuclear power.

  13. Master Pump Shutdown MPS Software Quality Assurance Plan (SQAP)

    International Nuclear Information System (INIS)

    The MPSS Software Quality Assurance (SQAP) describes the tools and strategy used in the development of the MPSS software. The document also describes the methodology for controlling and managing changes to the software

  14. Treatment of MPS I mice with microencapsulated cells overexpressing IDUA: effect of the prednisolone administration.

    Science.gov (United States)

    Lagranha, Valeska Lizzi; de Carvalho, Talita Giacomet; Giugliani, Roberto; Matte, Ursula

    2013-01-01

    Cell encapsulation, although a promising strategy to deliver therapeutic products, is hampered by immune response against biomaterials. The aim of this article is to assess the effect of prednisolone on enzyme release by microencapsulated cells implanted in vivo. Recombinant cells encapsulated were implanted in the peritoneum of wild-type mice and mucopolysaccharidosis (MPS) I mice, with or without prednisolone. Later, microcapsules were recovered for histological and enzyme analysis. Blood was collected from MPS I mice. All animals receiving prednisolone had a smaller inflammatory infiltrate. In vitro, prednisolone increased the amount of enzyme released from the recovered capsules, but this was not accompanied by an increase in the amount of circulating enzyme in vivo after 15 days. However, in 7 days, prednisolone significantly increased the amount of enzyme detected in the serum. Although prednisolone improved enzyme release in vitro and in vivo after 7 days, it was unable to maintain this effect for a longer period. PMID:23418953

  15. Band Structures and Physical Properties of Magnetic Layered Semiconductors MPS3

    Science.gov (United States)

    Kurita, Noriyuki; Nakao, Kenji

    1989-02-01

    The band structures of manganese chalcogeno-phosphate MnPS3 and iron chalcogeno-phosphate FePS3 are calculated self-consistently. From the calculation of the total energies of two types of magnetic structures of MnPS3, the experimentally observed magnetic structure is proved more stable. Furthermore, by comparing the band structures of MPS3 family (M=Mn, Fe, Ni, Zn), it is found that FePS3 and NiPS3 are more active to the Li intercalation than ZnPS3 and MnPS3, and that NiPS3 is the best cathode material in secondary lithium batteries in the MPS3 family.

  16. Preparation of P(DVB-co-MPS) inorganic-organic hybrid polymer microspheres

    Science.gov (United States)

    Wu, Chunrong; Zhang, Jimei; Dai, Zhao; Chen, Xiaoyu

    2010-07-01

    A novel inorganic-organic hybrid polymer microspheres were facilely synthesised by distillation-precipitation polymerization in absence of any stabilizer or surfcant. The process were conducted with [3-(Methacryloyloxy) propyl] trimethoxysilan (MPS) as monomer, divinyl benzene (DVB) as cross linking agent and azobisisobutyronitrile (AIBN) as initator in acetonitrile. A series of silica nanoparticles were prepared in accordance with the volume ratio of MPS, which was varied in the range of 10% to 50%. However, there is no microspheres obtained while the ratio up to 50%. Products were charactered by transmission electron micrograph (TEM) and fourier transform infrared spectroscopy (FTIR). We may infer it from the constructional formular and FTIR graph that there were silicon hydroxyl remained in the microsphere surface.

  17. MPS degeneration formula for quiver moduli and refined GW/Kronecker correspondence

    CERN Document Server

    Reineke, Markus; Weist, Thorsten

    2011-01-01

    Motivated by string-theoretic arguments Manschot, Pioline and Sen discovered a new remarkable formula for the Poincare polynomial of a smooth compact moduli space of stable quiver representations which effectively reduces to the abelian case (i.e. thin dimension vectors). We first prove a motivic generalization of this formula, valid for arbitrary quivers, dimension vectors and stabilities. In the case of complete bipartite quivers we use the refined GW/Kronecker correspondence between Euler characteristics of quiver moduli and Gromov-Witten invariants to identify the MPS formula for Euler characteristics with a standard degeneration formula in Gromov-Witten theory. Finally we combine the MPS formula with localization techniques, obtaining a new formula for quiver Euler characteristics as a sum over trees, and constructing many examples of explicit correspondences between quiver representations and tropical curves.

  18. Numerical analysis of jet injection mechanism of fuel-coolant interactions using MPS

    International Nuclear Information System (INIS)

    The numerical method used in this study is Moving Particle Semi-implicit (MPS) method which is based on moving particles and their interactions. Grids are not necessary, so that large fluid deformation can be calculated without numerical diffusion. To understand the fundamental physics of the jet penetration, water jet injection into a pool of a denser fluid under non-boiling and isothermal conditions is calculated using the MPS method. The density ratio of the denser fluid (Fluorinert) to water is 1.88. The calculation results are compared with experiments which were conducted in the ALPHA/MUSE facility at JAERI. In three-dimensional calculation, the penetration behavior agrees with the experiment. It is found that the jet penetration process is divided to two stages and, at the first stage, the coolant jet can penetrate deeper than existing correlations of breakup length. (author)

  19. Ubiquitin Ligase Ufd2 Is Required for Efficient Degradation of Mps1 Kinase

    Science.gov (United States)

    Liu, Chang; van Dyk, Dewald; Choe, Vitnary; Yan, Jing; Majumder, Shubhra; Costanzo, Michael; Bao, Xin; Boone, Charles; Huo, Keke; Winey, Mark; Fisk, Harold; Andrews, Brenda; Rao, Hai

    2011-01-01

    Ufd2 is a U-box-containing ubiquitylation enzyme that promotes ubiquitin chain assembly on substrates. The physiological function of Ufd2 remains poorly understood. Here, we show that ubiquitylation and degradation of the cell cycle kinase Mps1, a known target of the anaphase-promoting complex E3, require Ufd2 enzyme. Yeast cells lacking UFD2 exhibit altered chromosome stability and several spindle-related phenotypes, expanding the biological function of Ufd2. We demonstrate that Ufd2-mediated Mps1 degradation is conserved in humans. Our results underscore the significance of Ufd2 in proteolysis and further suggest that Ufd2-like enzymes regulate far more substrates than previously envisioned. PMID:22045814

  20. Advanced underground communication system development

    Energy Technology Data Exchange (ETDEWEB)

    Maenpaa, D.; Saindon, J.-P. (El-Equip, Sudbury, ON (Canada). VP Engineering)

    1992-09-01

    History, development, and trends of advanced communication systems for voice and data are outlined. Recent research that includes video transmission systems and systems for monitoring and control of automated equipment is reported. El-Equip MULTICOM system (a multi channel leaky feeder system), the 800 MHz DAS (distributed antenna system) technology, and a bimodal advanced network for digitally integrated telecommunications (BANDIT) for stationary equipment monitoring and control are discussed. BANDIT can interface equipment to provide information on ventilation, production, maintenance, electric power usage, and microseismic activity. 9 refs., 2 figs., 1 tab.

  1. Systemic Models of Local Development

    Directory of Open Access Journals (Sweden)

    Lucica Matei

    2007-01-01

    Full Text Available The paper approaches in a systemic manner the topic of local development, attempting, on one hand, to turn into account the previous contributions from the specialized literature and, on the other hand, to emphasize the specific mechanisms, describing and modelling the behavior of a local development system, underlining its feedback. The basic hypotheses of a systemic model for local development are synthesized in emphasizing three main subsystems, representing three levels of public management. At the same time, a local development system is composed by the convergence of two cybernetic systems, namely an administrative and an economic one, each with specific missions. Consequently, the paper aims a model for an economic-administrative system of local development (SEADL, whose self-regulation mechanisms are based on qualitative assessments, concerning the relevance or usefulness/sustainability of a local development policy as well as quantitative assessments, referring to efficiency or effectiveness. In the end of the paper a case study is presented in details, being achieved in Braila Municipality, valorising SEADL feedback, using assessments based on production factors or Keynesian approaches. The study represents only a framework, a general one for approaching a complex topic, such as local development, and it may be obviously completed and improved.

  2. Stilbazolium-MPS3 Nanocomposites with Large Second-Order Optical Nonlinearity and Permanent Magnetization.

    Science.gov (United States)

    Lacroix, P G; Clément, R; Nakatani, K; Zyss, J; Ledoux, I

    1994-02-01

    Intercalated layered materials comprising an organic dye and inorganic MPS(3) [where M is either the manganese ion (Mn(2+)) or the cadmium ion (Cd(2+))] phases have been prepared. The intercalation process induces a spontaneous poling, giving rise to an efficiency of 750 times that of urea in second-harmonic generation for the cadmium derivative. In addition, the manganese derivative displays a permanent magnetization below 40 kelvin. Thus, these materials exhibit both a large optical nonlinearity and magnetic ordering. PMID:17747659

  3. Enzyme replacement therapy for Mucopolysaccharidosis Type I among patients followed within the MPS Brazil Network.

    Science.gov (United States)

    Dornelles, Alícia Dorneles; de Camargo Pinto, Louise Lapagesse; de Paula, Ana Carolina; Steiner, Carlos Eduardo; Lourenço, Charles Marques; Kim, Chong Ae; Horovitz, Dafne Dain Gandelman; Ribeiro, Erlane Marques; Valadares, Eugênia Ribeiro; Goulart, Isabela; Neves de Souza, Isabel C; da Costa Neri, João Ivanildo; Santana-da-Silva, Luiz Carlos; Silva, Luiz Roberto; Ribeiro, Márcia; de Oliveira Sobrinho, Ruy Pires; Giugliani, Roberto; Schwartz, Ida Vanessa Doederlein

    2014-03-01

    Mucopolysaccharidosis type I (MPS I) is a rare lysosomal disorder caused by deficiency of alpha-L-iduronidase. Few clinical trials have assessed the effect of enzyme replacement therapy (ERT) for this condition. We conducted an exploratory, open-label, non-randomized, multicenter cohort study of patients with MPS I. Data were collected from questionnaires completed by attending physicians at the time of diagnosis (T1; n = 34) and at a median time of 2.5 years later (T2; n = 24/34). The 24 patients for whom data were available at T2 were allocated into groups: A, no ERT (9 patients; median age at T1 = 36 months; 6 with severe phenotype); B, on ERT (15 patients; median age at T1 = 33 months; 4 with severe phenotype). For all variables in which there was no between-group difference at baseline, a delta of ? ± 20% was considered clinically relevant. The following clinically relevant differences were identified in group B in T2: lower rates of mortality and reported hospitalization for respiratory infection; lower frequency of hepatosplenomegaly; increased reported rates of obstructive sleep apnea syndrome and hearing loss; and stabilization of gibbus deformity. These changes could be due to the effect of ERT or of other therapies which have also been found more frequently in group B. Our findings suggest MPS I patients on ERT also receive a better overall care. ERT may have a positive effect on respiratory morbidity and overall mortality in patients with MPS I. Additional studies focusing on these outcomes and on other therapies should be performed. PMID:24688287

  4. Biocompatible Polysiloxane-Containing Diblock Copolymer PEO-b-P?MPS for Coating Magnetic Nanoparticles

    OpenAIRE

    Chen, Hongwei; Wu, Xinying; Duan, Hongwei; Wang, Y. Andrew; Wang, Liya; Zhang, Minming; Mao, Hui

    2009-01-01

    We report a biocompatible polysiloxane containing amphiphilic diblock copolymer, poly(ethylene oxide)-block-poly(?-methacryloxypropyltrimethoxysilane) (PEO-b-P?MPS), for coating and stabilizing nanoparticles for biomedical applications. Such amphiphilic diblock copolymer which comprises both a hydrophobic segment with “surface anchoring moiety” (silane group) and a hydrophilic segment with PEO (Mn=5000 g/mol) was obtained by the reversible addition fragmentation chain transfer (RAFT) po...

  5. Bisphosphonate Treatment in a Patient Affected by MPS IVA with Osteoporotic Phenotype.

    Science.gov (United States)

    Tummolo, Albina; Gabrielli, Orazio; Gaeta, Alberto; Masciopinto, Maristella; Zampini, Lucia; Pavone, Luigi Michele; Di Natale, Paola; Papadia, Francesco

    2013-01-01

    Morquio A syndrome (Mucopolysaccharidosis type IVA) (MPS IVA) is a rare inherited metabolic disorder characterized by the defective degradation of keratan sulfate and chondroitin-6-sulfate. Classically, MPS IVA patients present with severe multisystemic involvement and have a short life expectancy. Attenuated forms with clinical features limited to minor skeletal abnormalities and short stature have also been described, sometimes associated to an early-onset osteoporotic phenotype. No treatment with allogenic bone marrow transplantation or gene therapy is currently available for Morquio A syndrome, and enzyme replacement therapy is under evaluation. We report a case of MPS IVA, who manifested tardily attenuated phenotype and significant bone mass reduction, which was treated with a bisphosphonate (BPN), resulting in an improvement of X-ray skeletal aspects and functional bone performance. We suggest that the use of bisphosphonates may be an interesting supportive therapeutic option for Morquio A patients with osteoporotic phenotype, but further studies involving more patients are necessary to confirm our findings. PMID:24348578

  6. Adaptive optics control system development

    Science.gov (United States)

    Hampton, Peter; Veran, Jean-Pierre; Bradley, Colin; Hilton, Aaron; Agathoklis, Pan

    2003-12-01

    This paper describes the current control system of the multi-conjugate adaptive optics (MCAO) test bench system that is being developed at the University of Victoria, BC, Canada. The design and analysis of a control system for an AO system employing a Micro-Electro-Mechanical-System (MEMS) based deformable mirror is presented. The AO system is part of a larger test bed that is a scale version of an 8-meter telescope. This paper focuses on the control of one deformable mirror with a Shack-Hartmann wave front sensor. Diagrams of how all the components work together as a control system are given. A conversion from actuator signal space to Zernike mode coefficients is presented. Analysis shows that this control system is capable of reducing low frequency aberrations. Shortcomings of the system error rejection are discussed. The steady state and step response to tilt simulated on the wave front sensor is shown.

  7. Cloning and molecular characterization of BumaMPs1, a novel metalloproteinases from the venom of scorpion Buthus martensi Karsch.

    Science.gov (United States)

    Xia, Xichao; Ma, Yuhong; Xue, Shipeng; Wang, Aimei; Tao, Junliang; Zhao, Yan; Zhang, Qingyuan; Liu, Rongzhi; Lu, Shaoe

    2013-12-15

    Scorpion venoms metalloproteinase is involved in a number of important biological, physiological and pathophysiological processes. In this work, a complete sequence of metalloproteinase was first obtained from venom of scorpion Buthus martensi and named as BumaMPs1. BumaMPs1 has 393 amino acid residues containing with a molecular mass of 44.53 kDa, showing an isoelectric point of 5.66. The primary sequence analysis indicated that the BumaMPs1 contains a zinc-binding motif (HELGHNLGISH), methionine-turn motif (YIM), disintegrin-like domain (ETCD) and N-glycosylation site. The multiple alignment of its deduced amino acid sequence and those of other metalloproteinase showed a high structural similarly, mainly among class reprolysin proteases. The phylogenetic analysis showed early divergence and independent evolution of BumaMPs1 from other metalloproteinase. PMID:24125658

  8. Yeast Mps1p Phosphorylates the Spindle Pole Component Spc110p in the N-terminal Domain*

    OpenAIRE

    Friedman, David B.; Kern, Joshua W.; Huneycutt, Brenda J.; Vinh, Dani B. N.; Crawford, Douglas K.; Steiner, Estelle; Scheiltz, David; Yates, John; Resing, Katheryn A.; Ahn, Natalie G.; Winey, Mark; Davis, Trisha N.

    2001-01-01

    The yeast spindle pole body (SPB) component Spc110p (Nuf1p) undergoes specific serine/threonine phosphorylation as the mitotic spindle apparatus forms, and this phosphorylation persists until cells enter anaphase. We demonstrate that the dual-specificity kinase Mps1p is essential for the mitosis-specific phosphorylation of Spc110p in vivo and that Mps1p phosphorylates Spc110p in vitro. Phosphopeptides generated by proteolytic cleavage were identified and sequenced by mass spectrometry. Ser60,...

  9. Common N-acetylgalactosamine-6-sulfate sulfatase (GALNS) exon mutations in Brazilian patients with mucopolysaccharidosis IVA (MPS IVA)

    OpenAIRE

    Tatiana Dieter; Ursula da Silveira Matte; Ida Vanessa Schwartz; Shunji Tomatsu; Roberto Giugliani

    2007-01-01

    Morquio A Syndrome (mucopolysaccharidosis IVA - MPS IVA, OMIM# 253000) is an autosomal recessive inborn error of metabolism caused by the deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS). We investigated five unrelated Brazilian MPS IVA families for mutations in exons 4, 5, 9 and 10 of the GALNS gene. Six out of the 10 mutant alleles were identified. Taken together with a previous study, which included six unrelated families, common mutations among Brazilian patients were p.N16...

  10. Development of animation processing system

    Energy Technology Data Exchange (ETDEWEB)

    Kato, Katsumi [Nuclear Energy Data Center, Tokai, Ibaraki (Japan); Watanabe, Tadashi; Machida, Masahiko; Kaburaki, Hideo

    1995-03-01

    Computer and network environment for image processing has been developed and maintained by the computing and information systems center under the course of establishing a distributed processing environment. A server workstation was introduced for image processing. An animation processing system, in which simulation results are consecutively visualized on the server workstation and automatically recorded on a video tape, has been developed. In this report, a system construction, visualization in the workstation using a visualization tool, control of video tape recorder and workstation, and production of animation video are described with some examples. (author).

  11. Development of the accelerating system

    International Nuclear Information System (INIS)

    One of the main purposes of the 'Development of the Accelerating System' is developing a 100-MeV proton linac which accelerate proton beams from 20 MeV to 100 MeV by using 7 DTL (drift tube linac) tanks. Two of them were finished in the 2-nd stage of the project. The remaining part was also successfully fabricated and installed at Gyeongju site of KAERI. The MEBT is an essential component to extract and supply 20-MeV proton beams to users, and to match proton beams to the next accelerating structure for 100-MeV acceleration. The development of the MEBT has successfully finished. The project also developed the digital LLRF (low level RF) system which control the accelerating field within 1% in magnitude and 1 degree in phase. This system has been successfully tested in the 20-MeV linac operation at Daejeon site of KAERI. The modified version of the digital LLRF system will be used in the 100-MeV linac operation. The project also developed the beam diagnostic system. They are the strip-line type beam position monitor (BPM), the beam current monitor (CT), the beam loss monitor (BLM), and the emittance measurement system. They are used to measure the characteristics of the 20-MeV proton beams. The project also developed the EPIC-based control system. It is used to monitor the status of the accelerator and components, and to remotely control accelerator components. It has been used and modified in the 20-MeV linac operation. The modified version of the LLRF, diagnostics and control systems will be used in 100-MeV linac operation

  12. Incremental value of 24-hour delayed imaging in 201Tl stress myocardial perfusion studies (MPS) with an 'early rest reinjection' protocol

    International Nuclear Information System (INIS)

    Full text: One hundred patients (pts) undergoing stress MPS had 24 h imaging for fixed defects at 4 h delayed imaging. 53 had prior myocardial infarction (MI) and 71 were males. Stress employed isotonic exercise with dipyridamole (0.56 mg kg-1) infusion in 57 pts, exercise alone in 33 and dipyridamole alone in 10. All pts with stress defects had rest-reinjection of 40 MBq of 201Tl after stress imaging had been completed, and most had sublingual nitrate therapy 10 min before reinjection. MPS from the 100 pts (15% of total) were read without clinical data, using a 20 segment scoring system. 51 pts showed -2 segments improvement between 4 and 24 h scores, but 22 pts had shown reversibility between stress and 4 h imaging and the further change did not alter interpretation. The other 29 pts (group A) showed clinically important change in 24 h scores, leaving 71 pts without clinical change (group B). Segmental improvement between 4 and 24 h in group A was 4.62 ± 2.18 and 1.18 ± 1.48 in group B (P = 0.02). Group A stress defect scores were not greater (10.90 ± 3.60) or more severe (3.72 ± 3.06) than in group B (8.92 ± 4.34 and 2.79 ± 3.11); 18 group A pts had MI compared with 38 group B pts. No significant correlation was found between improved 4-24 h scores and parameters of stress-LV dysfunction. There is benefit from 24 h, 201TI MPS in patients with persisting 4 h defects, despite early rest-reinjection and acute nitrate therapyction and acute nitrate therapy

  13. Development of isolation support system

    International Nuclear Information System (INIS)

    The isolation work during maintenance or inspection of nuclear power plants is very important for safety and a large number of isolation items are carried out. A computer support system is very effective to improve the reliability of the isolation. In Fugen Nuclear Power Station, an Isolation Support System (ISS) has been developed. This system adopts a Computer Aided Design (CAD) technique for isolation planning and controlling. With the help of this system, the user can control the state of the plant quickly by monitoring P and IDs on a work station, resolve the conflicts between the isolation items, plan isolation work very fast and save labor cost for planning. The objectives of the development thereby have been achieved; improvement of safety and reliability, optimization of isolation work and so on. This system was put into practical operation in July 1989. (author)

  14. Perturbed mononuclear phagocyte system in severely burned and septic patients.

    Science.gov (United States)

    Xiu, Fangming; Jeschke, Marc G

    2013-08-01

    Burn is one of the most common and devastating forms of trauma. Major burn injury disturbs the immune system, resulting in marked alterations in bone marrow hematopoiesis and a progressive suppression of the immune response, which are thought to contribute to increased susceptibility to secondary infections and the development of sepsis. Immunosuppression in patients with severe burn and sepsis leads to high morbidity and mortality in these patients. mononuclear phagocytes system (MPS) is a critical component of the innate immune response and plays key roles in burn immunity. These phagocytes are the first cellular responders to severe burn injury after acute disruption of the skin barrier. They are not only able to internalize and digest bacteria and dead cells and scavenge toxic compounds produced by metabolism, but also able to initiate an adaptive immune response. Severe burn and sepsis profoundly inhibit the functions of dendritic cells, monocytes, and macrophages. Adoptive transfer of MPS or stem cells to patients with severe burn and sepsis that aim to restore MPS function is promising. A better understanding of the roles played by MPS in the pathophysiology of severe burn and sepsis will guarantee a more rational and effective immunotherapy of patients with severe burn and sepsis. PMID:23860581

  15. Development of Dictionary Writing System.

    Czech Academy of Sciences Publication Activity Database

    Barbierik, Kamil; Holcová Habrová, Martina; Jarý, Vladimír; Kochová, Pavla; Liška, Tomáš; Opavská, Zde?ka; Virius, Miroslav

    Jihlava : College of Polytechnics, 2013 - (Molhanec, M.; Bej?ek, M.; Vorá?ek, J.), s. 133-147 ISBN 978-80-86847-66-5. [Federated conference on 39th Software Development and 17th Object Technologies (SDOT 2013). Jihlava (CZ), 08.11.2013] R&D Projects: GA MK DF13P01OVV011 Keywords : dictionary writing system * database system * lexicography Subject RIV: AI - Linguistics

  16. Pathogenesis of Morquio A syndrome: an autopsied case reveals systemic storage disorder.

    Science.gov (United States)

    Yasuda, Eriko; Fushimi, Kazunari; Suzuki, Yasuyuki; Shimizu, Katsuji; Takami, Tsuyoshi; Zustin, Jozef; Patel, Pravin; Ruhnke, Kristen; Shimada, Tsutomu; Boyce, Bobbie; Kokas, Terry; Barone, Carol; Theroux, Mary; Mackenzie, William; Nagel, Barbara; Ryerse, Jan S; Orii, Kenji E; Iida, Hiroki; Orii, Tadao; Tomatsu, Shunji

    2013-07-01

    Mucopolysaccharidosis IVA (MPS IVA; Morquio A syndrome) is a lysosomal storage disorder caused by deficiency of N-acetylgalactosamine-6-sulfate sulfatase, which results in systemic accumulation of glycosaminoglycans (GAGs), keratan sulfate and chondroitin-6-sulfate. Accumulation of these GAGs causes characteristic features as disproportionate dwarfism associated with skeletal deformities, genu valgum, pigeon chest, joint laxity, and kyphoscoliosis. However, the pathological mechanism of systemic skeletal dysplasia and involvement of other tissues remain unanswered in the paucity of availability of an autopsied case and successive systemic analyses of multiple tissues. We report here a 20-year-old male autopsied case with MPS IVA, who developed characteristic skeletal features by the age of 1.5 years and died of acute respiratory distress syndrome five days later after occipito-C1-C2 cervical fusion. We pathohistologically analyzed postmortem tissues including trachea, lung, thyroid, humerus, aorta, heart, liver, spleen, kidney, testes, bone marrow, and lumbar vertebrae. The postmortem tissues relevant with clinical findings demonstrated 1) systemic storage materials in multiple tissues beyond cartilage, 2) severely vacuolated and ballooned chondrocytes in trachea, humerus, vertebrae, and thyroid cartilage with disorganized extracellular matrix and poor ossification, 3) appearance of foam cells and macrophages in lung, aorta, heart valves, heart muscle, trachea, visceral organs, and bone marrow, and 4) storage of chondrotin-6-sulfate in aorta. This is the first autopsied case with MPS IVA whose multiple tissues have been analyzed pathohistologically and these pathological findings should provide a new insight into pathogenesis of MPS IVA. PMID:23683769

  17. Charged particle detector system for high rate experiments

    International Nuclear Information System (INIS)

    A charged particle detector system under development at BNL for use at the Multiparticle Spectrometer (MPS) and eventually at ISABELLE is described. The object is to take full advantage of the position accuracy, resolving time and instantaneous rate capabilities of narrow anode spacing drift-proportional chambers. The system will have position resolution sigma approximately equal to 100?, time resolution approximately equal to 8 ns, detector sensitive time approximately equal to 50 ns, and consecutive particle resolving power of 40 ns per wire. It is planned to implement this system in a large system of 30,000 wires at the MPS and greater than 100,000 wires in ISABELLE experiments. Central to the development of this detector system is the production of two custom integrated circuits

  18. Numerical analysis of freezing controlled penetration behavior of the molten core debris in an instrument tube with MPS

    International Nuclear Information System (INIS)

    Highlights: • The EPRI-3 melt solidification test was successfully analyzed by MPS code. • Analysis of the solidification behavior of molten UO2 and Fe in BWR instrument tube. • The melt had solidified and plugged the instrument tube in all the calculations. • Typical melt solidification behavior in instrument tube was revealed by MPS method. - Abstract: The freezing controlled penetration behavior of the molten core debris in the BWR instrument tube had been analyzed with a two dimensional geometry under severe accident conditions using Moving Particle Semi-implicit (MPS) method. The change of melt viscosity with temperature in the phase transition region was taken into account in the present MPS method. Accordingly, in order to improve the computation speed of such highly viscous fluid, the implicit calculation scheme was employed to solve the viscous term in this study. The surface tension model based on the inter-particle potential force was incorporated in the MPS method to track the melt leading front more accurately. The present MPS method was validated first by simulating the experiment of molten aluminum oxide penetrating in a prototypical PWR instrument tube which was performed by EPRI. The comparison of the predicted penetration length and the measured results showed a good agreement selecting a parameter. Then the penetration and solidification behaviors of molten stainless steel and uranium dioxide in the BWR instrument tube were simulated under a wide parametric range. The computational results showed that the melt penetration length increased with the melt superheat, and the melt had plugged the tube in all simulations. The melt flow resistance increased due to the formation of the crust on the tube surface and the increase of melt viscosity in the phase transition region. The present results indicated that the typical melt penetration and solidification behavior in the instrument tube was successfully revealed by MPS method

  19. Heating Systems Course Development Model

    Science.gov (United States)

    The Advanced Technology Environmental and Energy Center (ATEEC) has provided this course development model on heating systems, including gas, fuel oil, and electric furnaces, and heat pumps. Energy conservation, efficiency options and environmental impacts are also covered. Users must download this resource for viewing, which requires a free log-in. There is no cost to download the item.

  20. Copper vapor laser system development

    International Nuclear Information System (INIS)

    High-power, high-quality, and long-life copper vapor laser (CVL) system has been developed and operated. The system is composed of a small sized CVL oscillator with high beam quality, several high-power CVL amplifiers and related sub-systems such as special resonator optics, beam shaping and propagating optics, and pulse timing controller. Further developments of high-power amplifiers are being conducted for the next R and D targets. In our latest tests, the maximum output power of 480W has been achieved by optimizing discharge circuit conditions. Major-components life-time of more than 2000 hours has been also ensured in long-term CVL amplifier operation tests. Accumulated operation time of more than 700 hours has been achieved without refilling copper source or any maintenance. (author)

  1. Halon explosion protection system development

    International Nuclear Information System (INIS)

    A loss-of-coolant-accident in a water-cooled nuclear reactor could result in the accumulation of hydrogen and oxygen gases in the containment vessel, ignition of which might produce explosion pressures that exceed the containment design. Protection against suh a hazard can be provided by an inerting system which utilizes Halon 1301 (CF3Br). This inerting gas would be stored in the liquified state and injected only if needed. A development study is reported in which the quantity of Halon required for inerting has been measured, and several envisioned problems investigated. A sub-scale system has been fabicated and used to simulate operation of an actual system under post-LOCA conditions. The testing, together with a system analysis, indicates that the 1301 inerting concept is very suitable for containment application

  2. Characterization of a putative spindle assembly checkpoint kinase Mps1, suggests its involvement in cell division, morphogenesis and oxidative stress tolerance in Candida albicans.

    Science.gov (United States)

    Kamthan, Mohan; Nalla, Vijaya Kumar; Ruhela, Deepa; Kamthan, Ayushi; Maiti, Protiti; Datta, Asis

    2014-01-01

    In Saccharomyces cerevisiae MPS1 is one of the major protein kinase that governs the spindle checkpoint pathway. The S. cerevisiae structural homolog of opportunistic pathogen Candida albicans CaMPS1, is indispensable for the cell viability. The essentiality of Mps1 was confirmed by Homozygote Trisome test. To determine its biological function in this pathogen conditional mutant was generated through regulatable MET3 promoter. Examination of heterozygous and conditional (+Met/Cys) mps1 mutants revealed a mitosis specific arrest phenotype, where mutants showed large buds with undivided nuclei. Flowcytometry analysis revealed abnormal ploidy levels in mps1 mutant. In presence of anti-microtubule drug Nocodazole, mps1 mutant showed a dramatic loss of viability suggesting a role of Mps1 in Spindle Assembly Checkpoint (SAC) activation. These mutants were also defective in microtubule organization. Moreover, heterozygous mutant showed defective in-vitro yeast to hyphae morphological transition. Growth defect in heterozygous mutant suggest haploinsufficiency of this gene. qRT PCR analysis showed around 3 fold upregulation of MPS1 in presence of serum. This expression of MPS1 is dependent on Efg1 and is independent of other hyphal regulators like Ras1 and Tpk2. Furthermore, mps1 mutants were also sensitive to oxidative stress. Heterozygous mps1 mutant did not undergo morphological transition and showed 5-Fold reduction in colony forming units in response to macrophage. Thus, the vital checkpoint kinase, Mps1 besides cell division also has a role in morphogenesis and oxidative stress tolerance, in this pathogenic fungus. PMID:25025778

  3. Developing performance-appraisal systems.

    Science.gov (United States)

    Ross, S R

    1984-08-01

    The development and applications of performance-appraisal systems for hospital pharmacy personnel are discussed. The need for a performance-appraisal system is explained from the perspectives of the employee, the manager, and the hospital. Ethical standards that should be considered by managers during the appraisal process are listed. Performance standards are a key component of a performance-appraisal system and should be developed jointly by management and staff. Types of appraisal methods, personnel who should conduct appraisals, and the frequency at which appraisals should be conducted are discussed. Potential biases in appraisal methods and the preparation for and conduct of employee appraisals are discussed. A performance-appraisal system should be designed to meet the needs of employees, managers, and the hospital. Such a system will be more effective if it ensures the regular, frequent flow of data on employee performance, the systematic comparison of these data with previously agreed-upon expectations, and the frequent reporting of the results of these comparisons to both employees and managers. PMID:6475976

  4. Development of teleoperated cleanup system

    International Nuclear Information System (INIS)

    This report describes the development of a teleoperated cleanup system for use in a highly radioactive environment of DFDF(DUPIC Fuel Demonstration Facility) at KAERI where direct human access to the in-cell is strictly limited. The teleoperated cleanup system was designed to remotely remove contaminants placed or fixed on the floor surface of the hot-cell by mopping them with wet cloth. This cleanup system consists of a mopping slave, a mopping master and a control console. The mopping slave located at the in-cell comprises a mopping tool with a mopping cloth and a mobile platform, which were constructed in modules to facilitate maintenance. The mopping master that is an input device to control the mopping slave has kinematic dissimilarity with the mopping slave. The control console provides a means of bilateral control flows and communications between the mopping master and the mopping slave. In operation, the human operator from the out-of-cell performs a series of decontamination tasks remotely by manipulating the mopping slave located in-cell via a mopping master, having a sense of real mopping. The environmental and mechanical design considerations, and control systems of the developed teleoperated cleanup system are also described

  5. Development of teleoperated cleanup system

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Ki Ho; Park, J. J.; Yang, M. S.; Kwon, H. J

    2005-01-01

    This report describes the development of a teleoperated cleanup system for use in a highly radioactive environment of DFDF(DUPIC Fuel Demonstration Facility) at KAERI where direct human access to the in-cell is strictly limited. The teleoperated cleanup system was designed to remotely remove contaminants placed or fixed on the floor surface of the hot-cell by mopping them with wet cloth. This cleanup system consists of a mopping slave, a mopping master and a control console. The mopping slave located at the in-cell comprises a mopping tool with a mopping cloth and a mobile platform, which were constructed in modules to facilitate maintenance. The mopping master that is an input device to control the mopping slave has kinematic dissimilarity with the mopping slave. The control console provides a means of bilateral control flows and communications between the mopping master and the mopping slave. In operation, the human operator from the out-of-cell performs a series of decontamination tasks remotely by manipulating the mopping slave located in-cell via a mopping master, having a sense of real mopping. The environmental and mechanical design considerations, and control systems of the developed teleoperated cleanup system are also described.

  6. Networking systems design and development

    CERN Document Server

    Chao, Lee

    2009-01-01

    Effectively integrating theory and hands-on practice, Networking Systems Design and Development provides students and IT professionals with the knowledge and skills needed to design, implement, and manage fully functioning network systems using readily available Linux networking tools. Recognizing that most students are beginners in the field of networking, the text provides step-by-step instruction for setting up a virtual lab environment at home. Grounded in real-world applications, this book provides the ideal blend of conceptual instruction and lab work to give students and IT professional

  7. Development of pipe layout system

    International Nuclear Information System (INIS)

    In the plant design carried out so far, the process up to final drawings has been the repetition of the correction of drawings. This is because the space as the object of design is finite, and it is difficult to lay many pipes efficiently. Especially in nuclear power plants, the quantity of materials required for ensuring the safety and quality control is enormous, and only the skilled engineers having rich experience have become unable to deal with it. The model engineering using plastic models has been adopted, but still there are problems. In order to solve this problem, the development of the system for unitarily managing the various design information of plants with a computer, checking up various design with this information, automatically outputting design drawings and management data, and heightening the quality of design, synchronizing the progress, increasing the speed and saving the labor of design was carried out. This system is versatile and can be used for all plants. The emphasis in the development was placed on compact data structure, rapid picture processing and easy operation. The present status of design and the automation, the basic design of the system, the function of the system, the internal expression of models, the method of picture processing, and the results of application are reported. (Kako, I.)

  8. Development of internal pump systems

    International Nuclear Information System (INIS)

    In the reactor recirculation system of ABWRs, internal pump system has been adopted. This pump is of submerged motor type, and is directly installed on the bottom of a pressure vessel. It is an important machine to forcibly circulate core coolant. Also the power source and control facilities for driving this pump are the important equipment for adjusting the thermal output of a reactor by changing the rotating speed of the pump. In Hitachi Ltd., the examination of the design of ABWRs has been carried out jointly with GE in USA and Toshiba Corp., on the other hand, the components of the internal pump system, that is, the pump, motor, power source and control facilities, and pump and motor operating equipment, were developed and manufactured by its independent techniques. As for the individual machinery and equipment, various tests were carried out for grasping the performance of structures and materials, the characteristics of limiting the range of application and endurance of respective component elements. Also the synthetic test was carried out by combining respective components, and the well balanced function and performance were confirmed. The technical base for applying the internal pump system to ABWR plants was established by the general development and home manufacture using the independent techniques. (Kako, I.)

  9. Intercalation of polyethylene oxide PEO in layered MPS3 (M = Ni, Fe) materials

    International Nuclear Information System (INIS)

    The intercalation compounds Li0.96(H2O)0.77(PEO)0.63Ni0.48PS3 and Li0.94(H2O)0.92(PEO)0.94Fe0.48PS3 obtained by the insertion of PEO in MPS3 form lithium-polyethylene oxide complexes containing Li+ exchangeable cation in the interlayer space. Polyethylene oxide (PEO) is able to associate interlayer cation increasing the ionic conductivity of NiPS3 and FePS3. These compounds constitute a new family of intercalates MPS3 (M = Ni, Fe) host-layer materials. The new materials were characterized by powder X-Ray diffraction (XRD), Fourier-transformed infrared (FT-IR), differential thermal and thermogravimetric analyses (DTA/TG), energy dispersive X-Ray (EDX), inductively coupled plasma (ICP) and electrochemical impedance measurements. The intercalation compound Li0.96(H2O)0.77(PEO)0.63Ni0.48PS3 shows an ionic conductivity of 0.13 ?S/cm, and dc electronic conductivity of ca. 0.1 ?S/cm which is twice that of NiPS3

  10. Efficacy of StaMPS technique for monitoring surface deformation in L'Aquila, Italy

    Science.gov (United States)

    Tiwari, A.; Dwivedi, R.; Narayan, A. B.; Dikshit, O.; Singh, A. K.

    2014-11-01

    This research work investigates the efficacy of the Stanford Method for Persistent Scatterer Interferometry (StaMPS) in measuring the surface deformation over the L'Aquila region, Italy just before an event of earthquake of magnitude Mw 6.3 by using seven descending Envisat C-Band ASAR images. The results show that the StaMPS technique successfully extracted sufficient number of Persistent Scatterers (PS) to derive a one dimensional (1D) time series displacement map which shows the deformation rates up to 59 mm/year in the satellite Line of Sight (LOS) direction and 50.8 mm/year in the direction opposite to the satellite LOS. Further, several deformation gradients are also observed from this map which indicate the occurrence of multiple crustal movement mechanism. Another dataset of 14 ASAR images is processed covering a time period before and after the earthquake in the study area to validate the results obtained by the previous dataset. We observed that the generated displacement map follows the deformation characteristics of the earlier displacement map in terms of magnitude and surface movement. We conclude that the generated displacement maps validate the presence of a normal fault mechanism with a tectonic process stretching in a NW-SE direction as predicted by earlier research studies.

  11. Development of safeguards system simulator

    International Nuclear Information System (INIS)

    Due to a large plutonium (Pu) throughput and high burn-up fuel in an advanced reprocessing plant, we have the responsibility to undertake the inevitable burden of nuclear material accountancy (NMA) to meet the International Atomic Energy Agency (IAEA) safeguards criteria. A large amount of sampling analysis and inspectors' activities result in a great cost in facility operation to verify no concealment and undeclared use of Pu. In addition to NMA, containment and surveillance (C/S), process monitoring (PM), and curium (Cm) balance have been used for the safeguards activities to complement NMA. However, except for NMA, any mathematical or regulatory formalism in the safeguards measures have not been presented so far, therefore it is difficult to evaluate the cost-effective performance of the safeguards system. In order to design an advanced safeguards system for the fast reactor fuel cycle, the JAEA has started to develop a safeguards system simulator. A NMA core in the simulator is composed of a near-real-time accounting (NRTA) code which had been already developed and applied to investigate the NMA characteristics of JAEA facilities. A 'multivariate and multi-scale core' is based on a multivariate mathematical analysis combined with a multi-scale statistical process analysis making use of a wavelet decomposition forms safeguards envelope, which provides a control and monitoring system logic. Multi-scale principle component analysis of the core had been applied to 'maalysis of the core had been applied to 'material unaccounted for' (MUF). A concept of multiple optimization core is proposed as the safeguards formalism, with probabilistic risk analysis and cost-performance characteristics of the safeguards system, is discussed in the presentation. Flow meter and non-destructive analysis can be more broadly applied to the system in a cost-effective manner. A virtual design and objective-driven model will be developed in the simulator in the future to support an effective safeguards design and to develop a walk-through' virtual plant model. (author)

  12. Reciprocating Feed System Development Status

    Science.gov (United States)

    Trewek, Mary (Technical Monitor); Blackmon, James B.; Eddleman, David E.

    2005-01-01

    The reciprocating feed system (RFS) is an alternative means of providing high pressure propellant flow at low cost and system mass, with high fail-operational reliability. The RFS functions by storing the liquid propellants in large, low-pressure tanks and then expelling each propellant through two or three small, high-pressure tanks. Each RFS tank is sequentially filled, pressurized, expelled, vented, and refilled so as to provide a constant, or variable, mass flow rate to the engine. This type of system is much lighter than a conventional pressure fed system in part due to the greatly reduced amount of inert tank weight. The delivered payload for an RFS is superior to that of conventional pressure fed systems for conditions of high total impulse and it is competitive with turbopump systems, up to approximately 2000 psi. An advanced version of the RFS uses autogenous pressurization and thrust augmentation to achieve higher performance. In this version, the pressurization gases are combusted in a small engine, thus making the pressurization system, in effect, part of the propulsion system. The RFS appears to be much less expensive than a turbopump system, due to reduced research and development cost and hardware cost, since it is basically composed of small high- pressure tanks, a pressurization system, and control valves. A major benefit is the high reliability fail-operational mode; in the event of a failure in one of the three tank-systems, it can operate on the two remaining tanks. Other benefits include variable pressure and flow rates, ease of engine restart in micro-gravity, and enhanced propellant acquisition and control under adverse acceleration conditions. We present a system mass analysis tool that accepts user inputs for various design and mission parameters and calculates such output values payload and vehicle weights for the conventional pressure fed system, the RFS, the Autogenous Pressurization Thrust Augmentation (APTA) RFS, and turbopump systems. Using this tool, a preliminary design of a representative crew exploration vehicle (CEV) has been considered. The design parameters selected for a representative system were modeled after the orbital maneuvering system (OMS) on the Shuttle Orbiter, with an increase of roughly a factor of ten in the delta- V capability and a greater thrust (30,000 lbs, vs. 12,000 lbs). Both storable and cryogenic propellants were considered. Results show that a RFS is a low mass alternative to conventional pressure fed systems, with a substantial increase in payload capability and that it is weight-competitive with turbopump systems at low engine pressure (a few hundred psi); at high engine pressures, the APTA RFS appears to offer the highest payload. We also present the status of the RFS test bed fabrication, assembly, and checkout. This test bed is designed to provide flow rates appropriate for engines in the roughly 10,000 to 30,000 lb thrust range.

  13. Expert system development (ESD) shell

    International Nuclear Information System (INIS)

    An Expert System Development (ESD) Shell design implementation is desribed in detail. The shell provides high-level generic facilities for Knowledge Representation (KR) and inferencing and tools for developing user interfaces. Powerful set of tools in the shell relieves much of the programming burden in the ES development. The shell is written in PROLOG under IBM PC/AT. KR facilities are based on two very powerful formalisms namely, frames and rules. Inference Engine (IE) draws most of its power from unification and backward reasoning strategy in PROLOG. This basic mechanism is enhanced further by incorporating both forward and backward chaining of rules and frame-based inferencing. Overall programming style integrates multiple paradigms including logic, object oriented, access-oriented and imperative programming. This permits ES designer a lot of flexibility in organizing inference control. Creation and maintainance of knowledge base is a major activity. The shell, therefore, provides number of facilities to simplify these tasks. Shell design also takes note of the fact that final success of any system depends on end-user satisfaction and hence provides features to build use-friendly interfaces. The shell also provides a set of interfacing predicates so that it can be embedded within any PROLOG program to incorporate functionalilty of the shell in the user program. (author). 10 refs., 8 figs

  14. KSTAR RF heating system development

    Energy Technology Data Exchange (ETDEWEB)

    Kwak, J. G.; Kim, S. K.; Hwang, C. K. (and others)

    2007-10-15

    Design, high-voltage test, and installation of 6 MW ICRF heating system for KSTAR is completed. The antenna demonstrated satisfactory standoff at high voltages up to 41 kV for 300 sec. The result indicates good power handling capabilities of the antenna as high as 10 MW/m2. This power density is equivalent to RF power coupling of 6 MW into a 4 {omega}/m target plasma, and is typical of advanced tokamak heating scenarios. In addition, vacuum feed through, DC break, and liquid stub developed for 300 sec operation are installed, as well as a 2 MW, 30-60MHz transmitter. The transmitter successfully produced output powers of 600 kW continuously, 1.5{approx}1.8 MW for 300 sec, and 2 MW for 100 msec or shorter pulses. A realtime control system based on DSP and EPICS is developed, installed, and tested on the ICRF system. Initial results from feasibility study indicate that the present antenna and the transmission lines could allow load-resilient operation on KSTAR. Until the KSTAR tokamak start to produce plasmas in 2008, however, hands-on operational experiences are obtained from participating in ICRF heating experiments at ASDEX and DIII-D tokamaks arranged through international cooperation.

  15. KSTAR RF heating system development

    International Nuclear Information System (INIS)

    Design, high-voltage test, and installation of 6 MW ICRF heating system for KSTAR is completed. The antenna demonstrated satisfactory standoff at high voltages up to 41 kV for 300 sec. The result indicates good power handling capabilities of the antenna as high as 10 MW/m2. This power density is equivalent to RF power coupling of 6 MW into a 4 ?/m target plasma, and is typical of advanced tokamak heating scenarios. In addition, vacuum feed through, DC break, and liquid stub developed for 300 sec operation are installed, as well as a 2 MW, 30-60MHz transmitter. The transmitter successfully produced output powers of 600 kW continuously, 1.5?1.8 MW for 300 sec, and 2 MW for 100 msec or shorter pulses. A realtime control system based on DSP and EPICS is developed, installed, and tested on the ICRF system. Initial results from feasibility study indicate that the present antenna and the transmission lines could allow load-resilient operation on KSTAR. Until the KSTAR tokamak start to produce plasmas in 2008, however, hands-on operational experiences are obtained from participating in ICRF heating experiments at ASDEX and DIII-D tokamaks arranged through international cooperation

  16. Characterization on thermal stability of ZnS:Mn 2+/MPS/SiO 2 nano-phosphor film

    Science.gov (United States)

    Kubo, H.; Isobe, T.; Takahashi, H.; Itoh, S.

    2005-05-01

    When the screen-printed ZnS:Mn 2+ nano-phosphor film is heated under ambient condition, the photoluminescence (PL) intensity due to the d-d transition of Mn 2+ decreases with increasing temperatures. The coating of 3-mercaptopropyl trimethoxysilane (MPS) and SiO 2 around ZnS:Mn 2+ nanoparticles is effective to suppress the decrease in the PL intensity by heating. This is explained by suppressing the oxidation of ZnS:Mn 2+ nanoparticles and the carbonization of propyl chain in MPS by SiO 2 coating.

  17. STUDI DAYA HAMBAT IN VITRO ANTI MPS ECTO CIK (MAYOR PHYSIOLOGICAL PROTEIN SUBSTRAT TERHADAP VIABILITAS SPERMATOZOA KAMBING DAN DOMBA

    Directory of Open Access Journals (Sweden)

    Bayyinatul Muchtaromah

    2009-03-01

    Full Text Available Untuk menuju suatu penemuan tentang vaksin kontrasepsi bagi pria, diperlukan penelitian dasar mengenai hal tersebut. Sebagai langkah awal dilakukan uji hambatan Anti MPS ecto CIK terhadap viabilitas spermatozoa kambing dan domba, sedangkan dari penelitian pendahuluan diketahui bahwa anti MPS dari ecto-CIK ini mampu bereaksi silang dengan spermatozoa domba, dan sapi. Berdasarkan hal tersebut peneliti tertarik untuk mengetahui seberapa besar peranan anti MPS ecto CIK dalam menghambat viabilitas spermatozoa kambing dan domba secara in vitro.Tujuan dari penelitian ini adalah mengetahui seberapa besar peranan anti MPS ecto CIK dengan pemberian perlakuan konsentrasi dan lama inkubasi serta interaksi kedua perlakuan dalam menghambat viabilitas spermatozoa kambing dan domba. Rancangan penelitian yang digunakan adalah rancangan acak lengkap (RAL dengan pola faktorial yang terdiri atas 2 faktor utama, faktor pertama yaitu: dosis pengenceran, 0µl, 5µl, 10µl, dan 15µl, dan faktor kedua yaitu: lama inkubasi, yaitu 5 menit, 30 menit, 60 menit, dan 120 menit, masing-masing 6 kali ulangan. Data viabilitas spermatozoa kambing dan domba dianalisis dengan Uji one way ANOVA, jika hasil dari analisis tersebut terdapat pengaruh yang nyata maka akan dilanjutkan dengan Uji Jarak Berganda Duncan dengan taraf signifikansi 5% (0,05.Pemberian perlakuan anti MPS dari ecto CIK membran spermatozoa kambing dengan konsentrasi dan 0 µl, 5 µl, 10 µl, 15 µl dan lama inkubasi 5 menit, 30 menit, 60 menit dan 120 menit berpengaruh signifikan dalam menghambat viabilitas spermatozoa kambing dan domba. Pada perlakuan anti MPS ecto CIK dengan konsentrasi 15 µl dan lama inkubasi 120 menit merupakan perlakuan yang paling optimal dalam menghambat viabilitas spermatozoa kambing (45,50 ± 11,16%; 44,87 ± 9,40% dan domba (55,54 ± 18,87%; 40,58 ± 13,20%. Interaksi pemberian perlakuan konsentrasi dan lama inkubasi anti MPS ecto CIK pada konsentrasi 15 µl dan lama inkubasi 120 menit anti MPS ecto CIK paling berpengaruh dalam menghambat viabilitas spermatozoa domba (26,83 ± 8,70%, sedangkan pada kambing tidak berpengaruh.

  18. Computer aided training system development

    International Nuclear Information System (INIS)

    The first three phases of Training System Development (TSD) -- job and task analysis, curriculum design, and training material development -- are time consuming and labor intensive. The use of personal computers with a combination of commercial and custom-designed software resulted in a significant reduction in the man-hours required to complete these phases for a Health Physics Technician Training Program at a nuclear power station. This paper reports that each step in the training program project involved the use of personal computers: job survey data were compiled with a statistical package, task analysis was performed with custom software designed to interface with a commercial database management program. Job Performance Measures (tests) were generated by a custom program from data in the task analysis database, and training materials were drafted, edited, and produced using commercial word processing software

  19. Bone marrow transplantation in patients with storage diseases: a developing country experience

    OpenAIRE

    Lange Marcos C.; Teive Hélio A.G.; Troiano André R.; Bitencourt Marco; Funke Vaneuza A.M.; Setúbal Daniela C.; Zanis Neto José; Medeiros Carlos R. de; Werneck Lineu C.; Pasquini Ricardo; Bonfim Carmen M.S.

    2006-01-01

    Bone marrow transplantation (BMT) is a therapeutic option for patients with genetic storage diseases. Between 1979 and 2002, eight patients, four females and four males (1 to 13 years old) were submitted to this procedure in our center. Six patients had mucopolysaccharidosis (MPS I in 3; MPS III in one and MPS VI in 2), one had adrenoleukodystrophy (ALD) and one had Gaucher disease. Five patients had related and three unrelated BMT donor. Three patients developed graft versus host disease (tw...

  20. Energy systems analysis and development

    Energy Technology Data Exchange (ETDEWEB)

    Palmedo, P.F.

    1977-07-05

    The nature of energy problems, their technical and social complexity, and their long time scale places a high priority on broad-scale systems analysis as a basis for formulating national energy policy. A number of models have been developed recently that can be used for such analysis. The Federal Energy Administration PIES Model and the Brookhaven National Laboratory models are discussed briefly as examples. Models, however, as they currently exist must be used with caution in national planning, both because of their technical limitations and because of the restricted part of energy issues that admit to quantification. Suggestions are made for further extension of current analytical approaches.

  1. New HWIL motion system developments

    Science.gov (United States)

    Carter, John M.

    2001-08-01

    Performance and payload capacity requirements for hardware- in-the-loop motion systems have been growing. This paper describes several new systems that have advanced the state- of-the-art. A Four-Axis, electrically driven system weights 50 tons, has a 20,000-pound payload capacity, and approaches 1-arc second pointing accuracy. Several new hydraulic Five- Axis Flight Motion Simulators (FMS) have larger payload and increased acceleration/bandwidths. An environmentally hardened three-axis open range FMS will be installed atop a 300-foot tower. A new dual-target motion system installed at DERA in the UK is 56 feet wide, 41 feet tall, and has a 12- meter target radius. An electric Five-Axis FMS is under construction for the ballistic missile defense program. This machine will have continuous displacement on the three UUT axes and inner target axis, and achieves high dynamic and pointing accuracy with a 32-kg, 63-cm diameter payload. A new state-space controller has been developed for all Carco simulators.

  2. Computational Aeroacoustic Analysis System Development

    Science.gov (United States)

    Hadid, A.; Lin, W.; Ascoli, E.; Barson, S.; Sindir, M.

    2001-01-01

    Many industrial and commercial products operate in a dynamic flow environment and the aerodynamically generated noise has become a very important factor in the design of these products. In light of the importance in characterizing this dynamic environment, Rocketdyne has initiated a multiyear effort to develop an advanced general-purpose Computational Aeroacoustic Analysis System (CAAS) to address these issues. This system will provide a high fidelity predictive capability for aeroacoustic design and analysis. The numerical platform is able to provide high temporal and spatial accuracy that is required for aeroacoustic calculations through the development of a high order spectral element numerical algorithm. The analysis system is integrated with well-established CAE tools, such as a graphical user interface (GUI) through PATRAN, to provide cost-effective access to all of the necessary tools. These include preprocessing (geometry import, grid generation and boundary condition specification), code set up (problem specification, user parameter definition, etc.), and postprocessing. The purpose of the present paper is to assess the feasibility of such a system and to demonstrate the efficiency and accuracy of the numerical algorithm through numerical examples. Computations of vortex shedding noise were carried out in the context of a two-dimensional low Mach number turbulent flow past a square cylinder. The computational aeroacoustic approach that is used in CAAS relies on coupling a base flow solver to the acoustic solver throughout a computational cycle. The unsteady fluid motion, which is responsible for both the generation and propagation of acoustic waves, is calculated using a high order flow solver. The results of the flow field are then passed to the acoustic solver through an interpolator to map the field values into the acoustic grid. The acoustic field, which is governed by the linearized Euler equations, is then calculated using the flow results computed from the flow solver.

  3. AGING SYSTEM DESIGN DEVELOPMENT STRATEGY

    Energy Technology Data Exchange (ETDEWEB)

    J. Beesley

    2005-02-07

    This plan provides an overview, work to date, and the path forward for the design development strategy of the Aging cask for aging commercial spent nuclear fuel (CSNF) at the Yucca Mountain Project (YMP) repository site. Waste for subsurface emplacement at the repository includes US Department of Energy (DOE) high-level radioactive waste (HLW), DOE SNF, commercial fuel in dual-purpose canisters (DPCs), uncanistered bare fuel, naval fuel, and other waste types. Table 1-1 lists the types of radioactive materials that may be aged at YMP, and those materials that will not be placed in an aging cask or module. This plan presents the strategy for design development of the Aging system. The Aging system will not handle naval fuel, DOE HLW, MCOs, or DOE SNF since those materials will be delivered to the repository in a state and sequence that allows them to be placed into waste packages for emplacement. Some CSNF from nuclear reactors, especially CSNF that is thermally too hot for emplacement underground, will need to be aged at the repository.

  4. AGING SYSTEM DESIGN DEVELOPMENT STRATEGY

    International Nuclear Information System (INIS)

    This plan provides an overview, work to date, and the path forward for the design development strategy of the Aging cask for aging commercial spent nuclear fuel (CSNF) at the Yucca Mountain Project (YMP) repository site. Waste for subsurface emplacement at the repository includes US Department of Energy (DOE) high-level radioactive waste (HLW), DOE SNF, commercial fuel in dual-purpose canisters (DPCs), uncanistered bare fuel, naval fuel, and other waste types. Table 1-1 lists the types of radioactive materials that may be aged at YMP, and those materials that will not be placed in an aging cask or module. This plan presents the strategy for design development of the Aging system. The Aging system will not handle naval fuel, DOE HLW, MCOs, or DOE SNF since those materials will be delivered to the repository in a state and sequence that allows them to be placed into waste packages for emplacement. Some CSNF from nuclear reactors, especially CSNF that is thermally too hot for emplacement underground, will need to be aged at the repository

  5. ADASAGE, ADA Application Development System

    International Nuclear Information System (INIS)

    1 - Description of program or function: ADASAGE is an application development system designed to facilitate rapid and professional construction of applications written in Ada on microcomputers. ADASAGE applications may vary in size from small to large multi-program systems. ADASAGE consists of a collection of re-usable libraries for database management and form and report processing utilities having the following capabilities: basic universal type and function definitions; sequential file input/output; terminal and file input/output; DOS system command execution; data movement and fill; string manipulation; math libraries; bit manipulation; a relational database utility; data validation; menu form and window procedures; report generation; sort/merge, time, and date functions; sound production; editing; and index rebuilding. Each of the capabilities is integrated to allow the development of an efficient system. As an application is designed and developed, the desired ADASAGE capabilities are chosen and included along with any requirements unique to that application. 2 - Method of solution: All ADASAGE applications which use the database, forms (windows, menus, etc.), or reporting functions require a file with a suffix of .DFL. This file contains the database schema, the various forms and windows, and report definitions. The THOR editor is used to create and maintain the .DFL file. This editor operates on a file with the suffix .SRC and creates and edits schemes, forms,.SRC and creates and edits schemes, forms, and report formats and compile the .SRC file into the .DFL file used by the application. The application will have unique requirements not satisfied by the selected utilities of ADASAGE. The code for these along with the code necessary to import and use the selected ADASAGE utilities constitutes the programmed application. The completed application system will contain the .DFL file produced by the THOR editor, the required ADASAGE utilities, and the programmed application. During the course of normal database development and use, restructuring and/or rebuilding of database files may be required if the schema for a record is modified (new fields are added, changed, or deleted and new keys selected, etc.), or if the index file for a relation becomes damaged or is destroyed. Program REBUILD performs this task. The rebuilding process is invoked by supplying both an old .DFL file name identifying the schema definition under which the current data was written and a current .DFL file name identifying the new schema definition to which the current database must be changed. REBUILD compares the old and current schema definitions for a relation, adjusts the database files accordingly, and re-tags the database files with the new version so that access with the new schema is allowed. The index file for the relation is then rebuilt, and any unused space within the database files removed. 3 - Restrictions on the complexity of the problem: Maxima for each ADASAGE database are: 4,294,967,000 records (tuples) per record size; 32,000 bytes record (tuple) size; 32,000 fixed-length field (attribute size); 4,294,967,000 variable-length field (attribute) size; 1,000 relations (flat files); 1,000 joined relations; 1,000 views; 500 fields (attributes) per relation; 500 keyed fields per relation; 6,550 forms (windows); 55 significant digits in a number. The user's operating system or hardware may have more stringent limits than these

  6. Control of the electrical conductivity of composites of antimony doped tin oxide (ATO) nanoparticles and acrylate by grafting of 3-methacryloxypropyltrimethoxysilane (MPS).

    Science.gov (United States)

    Posthumus, Willem; Laven, Jozua; de With, Gijsbertus; van der Linde, Rob

    2006-12-15

    The effect of the addition of antimony doped tin oxide (ATO) nanoparticles on the electrical conductivity of acrylate films is described. To enable dispersing of ATO in acrylate matrices, 3-methacryloxypropyltrimethoxysilane (MPS) was grafted on the surface of the filler. The amount of MPS used for this surface modification was found to strongly affect the electrical conductivity. Surface modification with a large amount of MPS resulted in colloidally stable dispersions of ATO, leading to a homogeneous distribution. Surface modification with small amounts of MPS led to instable ATO dispersions and aggregation of ATO into a fractal type network, which gives a much higher conductivity especially at low-volume fractions. For composites with a fractal type ATO network a second effect was found. Decreasing the amount of on ATO grafted MPS resulted in an increase of the electrical conduction between the ATO particles. PMID:17010985

  7. Biocompatible polysiloxane-containing diblock copolymer PEO-b-PgammaMPS for coating magnetic nanoparticles.

    Science.gov (United States)

    Chen, Hongwei; Wu, Xinying; Duan, Hongwei; Wang, Y Andrew; Wang, Liya; Zhang, Minming; Mao, Hui

    2009-10-01

    We report a biocompatible polysiloxane containing amphiphilic diblock copolymer, poly(ethylene oxide)-block-poly(gamma-methacryloxypropyltrimethoxysilane) (PEO-b-PgammaMPS), for coating and stabilizing nanoparticles for biomedical applications. Such an amphiphilic diblock copolymer that comprises both a hydrophobic segment with "surface anchoring moiety" (silane group) and a hydrophilic segment with PEO (M(n) = 5000 g/mol) was obtained by the reversible addition-fragmentation chain transfer (RAFT) polymerization using the PEO macromolecular chain transfer agent. When used for coating paramagnetic iron oxide nanoparticles (IONPs), copolymers were mixed with hydrophobic oleic acid coated core size uniformed IONPs (D = 13 nm) in cosolvent tetrahydrofuran. After being aged over a period of time, resulting monodispersed IONPs can be transferred into aqueous medium. With proper PgammaMPS block length (M(n) = 10 000 g/mol), polysiloxane containing diblock copolymers formed a thin layer of coating (approximately 3 nm) around monocrystalline nanoparticles as measured by transmission electron microscopy (TEM). Magnetic resonance imaging (MRI) experiments showed excellent T(2) weighted contrast effect from coated IONPs with a transverse relaxivity r(2) = 98.6 mM(-1) s(-1) (at 1.5 T). Such thin coating layer has little effect on the relaxivity when compared to that of IONPs coated with conventional amphiphilic copolymer. Polysiloxane containing diblock copolymer coated IONPs are stable without aggregation or binding to proteins in serum when incubated for 24 h in culture medium containing 10% serum. Furthermore, a much lower level of intracellular uptake by macrophage cells was observed with polysiloxane containing diblock copolymers coated IONPs, suggesting the reduction of nonspecific cell uptakes and antibiofouling effect. PMID:20161520

  8. Project management for information system development

    OpenAIRE

    Zhang, Yang

    2011-01-01

    Nowadays, with the development of the information and communication technology, information systems have been developing rapidly. More and more software companies choose to develop the information system to be their main business. They want to increase their business profits by developing the information system. However, the failure rate of developing information system has been high during these years. The purpose of the thesis is to discover how to use project management knowledge to improv...

  9. Selective inhibition of pancreatic ductal adenocarcinoma cell growth by the mitotic MPS1 kinase inhibitor NMS-P715.

    Science.gov (United States)

    Slee, Roger B; Grimes, Brenda R; Bansal, Ruchi; Gore, Jesse; Blackburn, Corinne; Brown, Lyndsey; Gasaway, Rachel; Jeong, Jaesik; Victorino, Jose; March, Keith L; Colombo, Riccardo; Herbert, Brittney-Shea; Korc, Murray

    2014-02-01

    Most solid tumors, including pancreatic ductal adenocarcinoma (PDAC), exhibit structural and numerical chromosome instability (CIN). Although often implicated as a driver of tumor progression and drug resistance, CIN also reduces cell fitness and poses a vulnerability that can be exploited therapeutically. The spindle assembly checkpoint (SAC) ensures correct chromosome-microtubule attachment, thereby minimizing chromosome segregation errors. Many tumors exhibit upregulation of SAC components such as MPS1, which may help contain CIN within survivable limits. Prior studies showed that MPS1 inhibition with the small molecule NMS-P715 limits tumor growth in xenograft models. In cancer cell lines, NMS-P715 causes cell death associated with impaired SAC function and increased chromosome missegregation. Although normal cells appeared more resistant, effects on stem cells, which are the dose-limiting toxicity of most chemotherapeutics, were not examined. Elevated expression of 70 genes (CIN70), including MPS1, provides a surrogate measure of CIN and predicts poor patient survival in multiple tumor types. Our new findings show that the degree of CIN70 upregulation varies considerably among PDAC tumors, with higher CIN70 gene expression predictive of poor outcome. We identified a 25 gene subset (PDAC CIN25) whose overexpression was most strongly correlated with poor survival and included MPS1. In vitro, growth of human and murine PDAC cells is inhibited by NMS-P715 treatment, whereas adipose-derived human mesenchymal stem cells are relatively resistant and maintain chromosome stability upon exposure to NMS-P715. These studies suggest that NMS-P715 could have a favorable therapeutic index and warrant further investigation of MPS1 inhibition as a new PDAC treatment strategy. PMID:24282275

  10. Recent developments at MLLTRAP: Improving the system for mass measurements and in-trap observation of nuclear decays

    Energy Technology Data Exchange (ETDEWEB)

    Weber, C., E-mail: weber.ch@physik.uni-muenchen.de; Meißner, R.; Müller, P.; Thirolf, P.G.

    2013-12-15

    Highlights: • A MPS system for m/q separation is developed. • A “detector trap” inside a Penning trap magnet is developed for the future MATS facility. • A novel type of recoil-distance experiment is envisaged. -- Abstract: The MLLTRAP double Penning-trap setup, installed at the Maier-Leibnitz Laboratory in Garching, presently serves as an environment for development work for mass spectrometry and decay-spectroscopy experiments at future radioactive ion beam (RIB) facilities. Here, an m/q separator is presently being set up as an element for beam transport of charge-bred ions, which are required for mass measurements of highly-charged ions. Moreover, a novel type of experimental setup, dedicated to in-trap decay spectroscopy, is under development to be implemented in the future MATS facility at FAIR. It combines the high-resolution mass-purification capabilities of a Penning trap with a customized “detector-trap” setup, consisting of an arrangement of position-sensitive Si-strip detectors that replaces the conventional ring electrode of the trap, providing both, ion storage and detection of decay products. In this way, decay-spectroscopy experiments of mass-selected nuclides, trapped as a carrier-free source, thus avoiding any background or scattering effects, will become feasible via direct in situ spectroscopy of stored ions.

  11. The Simulator of the Timing and Magnitude of Pollen Season (STaMPS model: a pollen production model for regional emission and transport modeling

    Directory of Open Access Journals (Sweden)

    T. R. Duhl

    2013-04-01

    Full Text Available A pollen model that simulates the timing and production of wind-dispersed allergenic pollen by terrestrial, temperate vegetation has been developed to quantify how pollen occurrence may be affected by climate change and to investigate how pollen can interact with anthropogenic pollutants to affect human health. The Simulator of the Timing and Magnitude of Pollen Season (STaMPS model is driven by local meteorological conditions and is designed to be sensitive to climate shifts, as well as flexible with respect to the vegetation species and plant functional types (trees, grasses, etc. represented and the climate zones simulated. The initial focus for the model is the simulation of the pollen emission potential of important allergenic tree and grass species that typically flower between March–June in Southern California (S. CA, which is characterized by moderate Mediterranean and oceanic climate zones as well as regions of arid desert and arid steppe. Vegetation cover and species composition data are obtained from numerous datasets and a database of allergenic vegetation species, their pollen production potential and relative allergenicities has been developed. For the selected allergenic species and spring-early summer simulation period, temperature is the main driver controlling the timing of pollen release, while precipitation (and temperature, for some species controls the magnitude of pollen produced. The model provides species-specific pollen potential maps for each day of the simulation period; these are then used by a pollen transport model to simulate ambient pollen concentrations as described in a companion paper (Zhang et al., 2013a, which also presents model evaluation results for the S. CA model domain. The STaMPS model was also used to quantify the possible impact of climate change on pollen season under the IPCC SRES A1B scenario as simulated by the ECHAM5 global climate model. Current (1995–2004 and future (2045–2054 meteorological conditions downscaled using the Weather Research and Forecasting (WRF model were used to drive STaMPS and generate estimates of the relative magnitude and timing of pollen season for important allergenic tree and grass species that bloom from March through June in a larger domain that covers all of CA and Nevada. Differences in the simulated timing and magnitude of pollen season for the selected allergenic species under current and future climate scenarios are presented. The results suggest that across all of the simulated species, pollen season starts an average of 5–6 days earlier under predicted future climatic conditions with an associated average annual domain-wide temperature increase of about 1°C compared to simulated current conditions. Differences in the amount of pollen produced under the two scenarios vary by species and are affected by the selected simulation period (1 March–30 June. Uncertainties associated with the STaMPS model and future model development plans are also discussed.

  12. Development Of Advanced Welding Control System

    Science.gov (United States)

    1990-01-01

    Report describes development of next-generation control system for variable-polarity plasma arc (VPPA) welding. When fully developed, system expected to incorporate advanced sensors and adaptive control of position of and current in welding torch.

  13. Technical developments of OTEC Systems

    Energy Technology Data Exchange (ETDEWEB)

    Trenka, A.R.; Thomas, A.; Vega, L.

    1988-01-01

    The US Department of Energy's (DOE) Ocean Energy Technology Program seeks to develop the technology of converting the ocean's vast energy resource into usable forms to the point where industry can assess its potential, commercial utility. The current focus in the program is on the utilization of open-cycle OTEC to produce electricity. The open-cycle OTEC process is one of the few alternative energy options which provides the potential for baseload-carrying capability. This paper provides a very brief overview of the program activities and focuses on results recently obtained from the program's experimental facility designed to allow testing of OC-OTEC subsystems under actual operating conditions utilizing seawater. The facility, referred to as the Seacoast Test Facility (STF), is currently composed of a Heat and Mass Transfer Scoping Test Apparatus (HMTSTA) being supplied by up to 1600 gallons per minute of warm seawater and 1000 gallons per minute of cold seawater. Researchers have obtained experimental data on the performance of evaporators and surface condensers. Also, information on mist elimination and deaeration processes have been obtained. Plans call for modification to the HMTSTA to accommodate the addition of direct-contact condensers. Summary results will be discussed addressing recent studies, by Argonne National Laboratory (ANL), of corrosion and biofouling of aluminum alloy surface condensers. Also discussed is the production of desalinated seawater using an open-cycle OTEC process. Finally to be discussed will be recent developments in OTEC turbines and an assessment of seawater supply systems required for OTEC. A brief overview of the program's future plans also will be presented. 4 refs., 11 figs., 2 tabs.

  14. Evaluation of the personnel development system

    OpenAIRE

    Kumpikaite?, Vilmante?

    2005-01-01

    The aim of the research – taking into account requirements raised to personnel development, to prepare model of the personnel development system evaluation, focused on consistency of the organisation and its employee’s development interests.

  15. Developing Information Systems for Competitive Intelligence Support.

    Science.gov (United States)

    Hohhof, Bonnie

    1994-01-01

    Discusses issues connected with developing information systems for competitive intelligence support; defines the elements of an effective competitive information system; and summarizes issues affecting system design and implementation. Highlights include intelligence information; information needs; information sources; decision making; and…

  16. Reactivity of the [M(PS)2](+) Building Block (M = Re(III) and (99m)Tc(III); PS = Phosphinothiolate) toward Isopropylxanthate and Pyridine-2-thiolate.

    Science.gov (United States)

    Salvarese, Nicola; Dolmella, Alessandro; Refosco, Fiorenzo; Bolzati, Cristina

    2015-02-16

    The coordination properties of isopropylxanthate (i-Pr-Tiox) and pyridine-2-thiolate (PyS) toward the [M(PS)2](+) moiety (M = Re and (99m)Tc; PS = phosphinothiolate) were investigated. Synthesis and full characterization of [Re(PS2)2(i-Pr-Tiox)] (Re1), [Re(PSiso)2(i-Pr-Tiox)] (Re2), [Re(PS2)2(PyS)] (Re3), and [Re(PSiso)2(PyS)] (Re4), where PS2 = 2-(diphenylphosphino)ethanethiolate and PSiso = 2-(diisopropylphosphino)ethanethiolate, and the structural X-ray analysis of complex Re3 were carried out. (99m)Tc analogues of complexes Re2 ((99m)Tc2) and Re4 ((99m)Tc4) were obtained in high radiochemical yield following a simple one-pot procedure. The chemical identity of the radiolabeled compounds was confirmed by chromatographic comparison with the corresponding rhenium complexes and by dual radio/UV HPLC analysis combined with ESI(+)-MS of (99g/99m)Tc complexes prepared in carrier-added conditions. The two radiolabeled complexes were stable with regard to trans chelation with cysteine, glutathione, and ethylenediaminotetraacetic acid and in rat and human sera. This study highlights the substitution-inert metal-fragment behavior of the [M(PS)2](+) framework, which reacts with suitable bidentate coligands to form stable hexacoordinated asymmetrical complexes. This feature makes it a promising platform on which to develop a new class of Re/Tc complexes that are potentially useful in radiopharmaceutical applications. PMID:25588027

  17. Embedded Automotive System Development Process

    OpenAIRE

    Langenwalter, Joachim

    2007-01-01

    Model based design enables the automatic generation of final-build software from models for high-volume automotive embedded systems. This paper presents a framework of processes, methods and tools for the design of automotive embedded systems. A steer-by-wire system serves as an example.

  18. AGE-RELATED FUNCTIONAL AND HISTOPATHOLOGICAL CHANGES OF THE EAR IN THE MPS I MOUSE

    Science.gov (United States)

    Schachern, Patricia A.; Cureoglu, Sebahattin; Tsuprun, Vladimir; Paparella, Michael M.; Whitley, Chester

    2007-01-01

    Objective Mucopolysaccharidosis type I (MPS I) is an autosomal recessive disorder caused by a mutation in the gene encoding the enzyme ?-L-iduronidase. This enzyme is responsible for degradation of dermatan and heparan sulfates. Enzyme deficiency results in their accumulation in lysosomes of virtually all organs, resulting in severe somatic and neurological changes. Clinical findings of otitis media with mixed hearing loss are common. Cellular and molecular mechanisms of ear pathology and hearing loss are not understood. The purpose of this study is to describe the age-related audiologic and histopathologic changes of the ear in the mouse model of MPS I. Methods Auditory brainstemresponses (ABR) were obtained to clicks and tone bursts at 1-32 kHz, and pathological changes to middle and inner ears were studied with light and electron microscopy in fifty-three mice that included: 1) wild type (+/+) - five at 2 months, five at 4 to 6 months, and five at 13 to 19 months; 2) heterozygotes (+/?) - four at 2 months; five at 4 to 6 months; and eight at 13 to 19 months; and 3) homozygotes (?/?); five at 2 months; six at 4 to 6 months; and five at 13 to 19 months. Histopathology was also done on five newborn ?/? mice. Results In newborns no lysosomal storage was observed and the ear appeared age appropriately normal. In all other ?/? mice, cells with lysosomal storage vacuoles were observed in spiral ligament, spiral prominence, spiral limbus, basilar membrane, epithelial and mesothelial cells of Reissner’s membrane, endothelial cells of vessels, and some ganglion cells; their number increased with aging. Hair cell loss was not observed at 2 or 6 months, but there was total loss of the organ of Corti in year-old mice. Hearing of ?/? mice was significantly decreased at all ages compared to +/+ and +/?. Hearing loss progressed from mild to moderate loss at 2 months to profound at 6 months and total deafness by one year of age. Conclusions Progressive age-related changes suggest early therapeutic intervention to prevent sensory cell damage and hearing loss. PMID:17101178

  19. Bone marrow transplantation in patients with storage diseases: a developing country experience Transplante de medula óssea em pacientes com doença de acúmulo: experiência de um país em desenvolvimento

    OpenAIRE

    Lange, Marcos C.; Teive, He?lio A. G.; Troiano, Andre? R.; Marco Bitencourt; Funke, Vaneuza A. M.; Setu?bal, Daniela C.; José Zanis Neto; Medeiros, Carlos R.; Werneck, Lineu C.; Ricardo Pasquini; Bonfim, Carmen M. S.

    2006-01-01

    Bone marrow transplantation (BMT) is a therapeutic option for patients with genetic storage diseases. Between 1979 and 2002, eight patients, four females and four males (1 to 13 years old) were submitted to this procedure in our center. Six patients had mucopolysaccharidosis (MPS I in 3; MPS III in one and MPS VI in 2), one had adrenoleukodystrophy (ALD) and one had Gaucher disease. Five patients had related and three unrelated BMT donor. Three patients developed graft versus host disease (tw...

  20. Development on structural health monitoring system

    International Nuclear Information System (INIS)

    The authors have developed ''structural health monitoring system'' comprised of sensing, data processing and diagnosis subsystems, for building and civil infrastructure. In this paper, application of this SHM system to the actual buildings with vibration suppression system and base isolation system are introduced. Internet-based data processing and analysis system is also successfully utilized in these buildings. (author)

  1. Developing systems to support organisational learning in product development organisations

    OpenAIRE

    Donnellan, Brian; Fitzgerald, Brian

    2003-01-01

    There are aspects of New Product Development (NPD) business processes that pose particularly difficult challenges to Organizational Learning systems. Short product and process life cycles compress the available time window for recouping the expenses associated with product development. Cross-functional collaboration in product development organizations requires the merging of knowledge from diverse disciplinary and personal skills-based perspectives. Cross-institutional collaboration...

  2. Development of organic storage system

    International Nuclear Information System (INIS)

    Organic Storage System is designed to absorb the massive data flow with low TCO. The system scales unlimitedly to store the data that keeps growing, and undergoes metabolic change to provide data longevity. Its high-data-mobility feature enables quick replication and migration for disaster recovery and self-healing. (author)

  3. [Development of smart infusion system].

    Science.gov (United States)

    Li, Junyang

    2014-01-01

    The free care smart infusion system which has the function of liquid end alarm and automatic stopping has been designed. In addition, the system can send the alarm to the health care staff by Zigbee wireless network. Besides, the database of infusion information has been set up, it can be used for inquiry afterwards. PMID:24839846

  4. Development of diagnostic system for NPP

    International Nuclear Information System (INIS)

    State of art of works in the area of the diagnostic system organization at NPP is described. Diagnostic methods used at present and their application areas are characterized in short. Trends of development on the basis of these methods of existing diagnostics systems are also described as well as their gradual approach to artificial intellect systems on the basis of new developments is underlined

  5. Development of Baby-EBM Interface System

    International Nuclear Information System (INIS)

    This paper explains the works being done to develop an interface system for Baby-Electron Beam Machine (EBM). The function of the system is for the safety, controlling and monitoring the Baby-EBM. The integration for the system is using data acquisition (DAQ) hardware and LabVIEW to develop the software. (author)

  6. Magnetic properties and specific heat of MPS3 (M=Mn, Fe, Zn)

    International Nuclear Information System (INIS)

    The magnetic properties and specific heat of MPS3 (M=Mn, Fe and Zn) have been investigated. While ZnPS3 is non-magnetic, MnPS3 and FePS3 are antiferromagnets with the Neel temperature TN of 78 and 118 K, respectively. Nevertheless, the specific heat of MnPS3 and FePS3 is smaller than that of ZnPS3 below about 20 K. The temperature dependence of the magnetic specific heat CM of MnPS3 shows a broad hump which is characteristic to the two dimensional magnetic materials and a small sharp peak at TN. On the other hand, that of FePS3 shows a large sharp peak at TN. As for FePS3, the temperature dependences of the magnetization M and CM are well reproduced by taking account of the magneto-elastic effect which introduces an additional term proportional to the square of the average value of the spin to the exchange coupling constant. As for MnPS3, marked two dimensional characters appear in the temperature dependence of M and CM. The observed TN is much smaller than the paramagnetic Curie temperature of 240 K obtained from the temperature dependence of the magnetic susceptibility at high temperature

  7. Development of logistics information systems

    OpenAIRE

    Z?, Milan Dronjak; Milenkov, Marjan A.

    2012-01-01

    An adequate logistics information system provides real time automated data processing, distribution and of information according to Terrain Commander's requirements, which leads to timely fulfillment of logistic demands of units. SAP ERP The SAP ERP application is the integrated (ERP) software capable of working with complex organisational structures, personnel, equipment, and finance. It enables planning and combining forces for every type of operations. The system also enables the determina...

  8. Measurement of radioactivity by microplate-radioluminography. Development of microplate-evaporator

    Energy Technology Data Exchange (ETDEWEB)

    Baba, Shigeo [Tokyo Coll. of Pharmacy, Hachioji (Japan); Kimata, Hideki; Koide, Takashi; Ogawa, Sosaburo

    2000-05-01

    A simple device for evaporating the sample solutions in 48 well-microplates (MP) was developed in order to facilitate the application of MP-radioluminography (RLG). The proposed device makes it possible to dry-up six MPs containing 0.2 ml water in each well within 1.5 h at one time. The MPs were placed overnight in a desiccator. The cross radioactive contamination accompanied with the evaporation process was not detected. A slight increase in the background photo-stimulated luminescence (PSL) value that was observed in the wells adjacent a radiation well could be attributed to a flare caused during analysis by a bio-imaging analyzer system (BAS). The detection limit of the MP-RLG was 0.05 Bq{sup 14}C, when the evaporated MP was brought into contact with an imaging plate for 72 h and analyzed by a BAS. (author)

  9. Heteroallelic missense mutations of the galactosamine-6-sulfate sulfatase (GALNS) gene in a mild form of Morquio disease (MPS IVA).

    Science.gov (United States)

    Cole, D E; Fukuda, S; Gordon, B A; Rip, J W; LeCouteur, A N; Rupar, C A; Tomatsu, S; Ogawa, T; Sukegawa, K; Orii, T

    1996-06-28

    Morquio disease (MPS IVA) is an autosomal recessive disorder caused by a deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS) activity. Patients commonly present in early infancy with growth failure, spondyloepiphyseal dysplasia, corneal opacification, and keratan sulfaturia, but milder forms have been described. We report on a patient who grew normally until age 5 years. Her keratan sulfaturia was not detected until adolescence, and she now has changes restricted largely to the axial skeleton. She has experienced only mildly impaired vision. At age 22, thin-layer chromatography of purified glycosaminoglycans showed some keratan sulfaturia. GALNS activity in fibroblast homogenate supernatants was 20 +/- 5% of controls (as compared to 5 +/- 3% of controls in severe MPS IVA, P < .003). Kinetic analysis of residual fibroblast GALNS activity in patient and parents revealed decreased K(m) and increased Vmax in the mother and daughter, but not in the father, compatible with compound heterozygosity. GALNS exons were amplified from patient genomic DNA and screened by SSCP. Two missense mutations, a C to T transition at position 335 (predicting R94C) and a T to G transversion at position 344 (predicting F97V), were found on sequencing an abnormally migrating exon 3 amplicon. Digestion of the amplicon with FokI and AccI restriction enzymes (specific for the R94C and F97V mutations, respectively) confirmed heterozygosity. In fibroblast transfection experiments, heterozygous R94C and F97V mutants independently expressed as severe and mild GALNS deficiency, respectively. We interpret these findings to indicate that our patient bears heteroallelic GALNS missense mutations, leading to GALNS deficiency and mild MPS IVA. Our findings expand the clinical and biochemical phenotype of MPS IVA, but full delineation of the genotype-phenotype relationship requires further study of native and transfected mutant cell lines. PMID:8826435

  10. Heteroallelic missense mutations of the galactosamine-6-sulfate sulfatase (GALNS) gene in a mild form of Morquio disease (MPS IVA)

    Energy Technology Data Exchange (ETDEWEB)

    Cole, D.E.C. [Univ. of Toronto, Ontario (Canada); Gordon, B.A.; Rupar, C.A. [Univ. of Western Ontario, London (Canada)] [and others

    1996-06-28

    Morquio disease (MPS IVA) is an autosomal recessive disorder caused by a deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS) activity. Patients commonly present in early infancy with growth failure, spondyloepiphyseal dysplasia, corneal opacification, and keratan sulfaturia, but milder forms have been described. We report on a patient who grew normally until age 5 years. Her keratan sulfaturia was not detected until adolescence, and she now has changes restricted largely to the axial skeleton. She has experienced only mildly impaired vision. At age 22, thin-layer chromatography of purified glycosaminoglycans showed some keratan sulfaturia. GALNS activity in fibroblast homogenate supernatants was 20 {plus_minus} 5% of controls (as compared to 5 {plus_minus} 3% of controls in severe MPS IVA, P <.003). Kinetic analysis of residual fibroblast GALNS activity in patient and parents revealed decreased K{sub m} and increased V{sub max} in the mother and daughter, but not in the father, compatible with compound heterozygosity. GALNS exons were amplified from patient genomic DNA and screened by SSCP. Two missense mutations, a C to T transition at position 335 (predicting R94C) and a T to G transversion at position 344 (predicting F97V), were found on sequencing an abnormally migrating exon 3 amplicon. Digestion of the amplicon with FokI and AccI restriction enzymes (specific for the R94C and F97V mutations, respectively) confirmed heterozygosity. In fibroblast transfection experiments, heterozygous R94C and F97V mutants independently expressed as severe and mile GALNS deficiency, respectively. We interpret these findings to indicate that our patient bears heteroallelic GALNS missense mutations, leading to GALNS deficiency and mild MPS IVA. Our findings expand the clinical and biochemical phenotype of MPS IVA, but full delineation of the genotype-phenotype relationship requires further study of native and transfected mutant cell lines. 30 refs., 4 figs., 3 tabs.

  11. Development of geophysical data management system

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Tai-Sup; Lee, Sang-Kyu; Gu, Sung-Bon [Korea Institute of Geology Mining and Materials, Taejon (KR)] (and others)

    1999-12-01

    (1) Development of a complete geophysical database system under C/S environment for data management. (2) Development of database system for the general user, who has not special knowledge of database, under the Internet environment. (3) Operation of the Web service for the general user. (4) Development of the stand-alone database system for a small-scale research group such as college and engineering consultant firms. (author). 15 refs.

  12. Development of the Zebrafish Enteric Nervous System

    OpenAIRE

    Shepherd, Iain; Eisen, Judith

    2011-01-01

    The enteric nervous system is composed of neurons and glia that modulate many aspects of intestinal function. The ability to use both forward and reverse genetic approaches and to visualize development in living embryos and larvae has made zebrafish an attractive model in which to study mechanisms underlying enteric nervous system development. Here we review recent work describing the development and organization of the zebrafish enteric nervous system and how this relates to intestinal motil...

  13. CATALYTIC COMBUSTION COMPONENT AND SYSTEM PROTOTYPE DEVELOPMENT

    Science.gov (United States)

    The report gives results of a project to develop the components required for catalytic combustion system operation and evaluation. The systems investigated (firetube boiler, watertube boiler, and gas turbine), when integrated with the catalytic combustor, have potential for both ...

  14. The development of wireless area monitoring system

    International Nuclear Information System (INIS)

    A wireless monitoring system was developed in the Fugen nuclear power station to measure the dose rate changes of radiation working areas in the reactor building. The system provided real time information to operators during the chemical decontamination campaign performed in 1989 and 1991. The system markedly reduced occupational radiation dose with manual dose rate monitoring. Development history of the system and benefits provided are described. (author)

  15. Therapeutic Efficacy of Bone Marrow Transplant, Intracranial AAV-mediated Gene Therapy, or Both in the Mouse Model of MPS IIIB

    OpenAIRE

    Heldermon, Coy D.; Ohlemiller, Kevin K.; Herzog, Erik D.; Vogler, Carole; Qin, Elizabeth; Wozniak, David F.; Tan, Yun; Orrock, John L.; Sands, Mark S.

    2010-01-01

    Sanfilippo syndrome type B (MPS IIIB) is a lysosomal storage disease resulting from a deficiency of N-acetyl-glucosaminidase (NAGLU) activity. In an attempt to correct the disease in the murine model of MPS IIIB, neonatal mice were treated with intracranial AAV2/5-NAGLU (AAV), syngeneic bone marrow transplant (BMT), or both (AAV/BMT). All treatments resulted in some improvement in clinical phenotype. Adeno-associated viral (AAV) treatment resulted in improvements in lifespan, motor function, ...

  16. Elements of a successful safeguards system development

    International Nuclear Information System (INIS)

    The material control and accounting system in place in the nuclear fuel facility of the General Electric Wilmington Manufacturing Department has received national and international recognition as one of the best in the nuclear industry. Although only low enriched uranium is processed in the facility, the system has been identified as a model Material Control and Accounting tool capable of handling safeguards requirements applicable to high enriched uranium processing. The development of the system can also serve as a model for other systems, and this report is essentially a ''how to'' description of the GE experience. Important facets of the system development included actions taken to enhance input data accuracy, the diversity and depth in experience of the development team, the adequacy of the resources committed to development, and top management support of the project. Most provocative was the concept of the need for an integrated manufacturing information system rather than a safeguards system per se

  17. First human treatment with investigational rhGUS enzyme replacement therapy in an advanced stage MPS VII patient.

    Science.gov (United States)

    Fox, Joyce E; Volpe, Linda; Bullaro, Josephine; Kakkis, Emil D; Sly, William S

    2015-02-01

    Mucopolysaccharidosis type VII (MPS VII, Sly syndrome) is a very rare lysosomal storage disease caused by a deficiency of the enzyme ?-glucuronidase (GUS), which is required for the degradation of three glycosaminoglycans (GAGs): dermatan sulfate, heparan sulfate, and chondroitin sulfate. Progressive accumulation of these GAGs in lysosomes leads to increasing dysfunction in numerous tissues and organs. Enzyme replacement therapy (ERT) has been used successfully for other MPS disorders, but there is no approved treatment for MPS VII. Here we describe the first human treatment with recombinant human GUS (rhGUS), an investigational therapy for MPS VII, in a 12-year old boy with advanced stage MPS VII. Despite a tracheostomy, nocturnal continuous positive airway pressure, and oxygen therapy, significant pulmonary restriction and obstruction led to oxygen dependence and end-tidal carbon dioxide (ETCO2) levels in the 60-80mmHg range, eventually approaching respiratory failure (ETCO2 of 100mmHg) and the need for full-time ventilation. Since no additional medical measures could improve his function, we implemented experimental ERT by infusing rhGUS at 2mg/kg over 4h every 2weeks for 24weeks. Safety was evaluated by standard assessments and observance for any infusion associated reactions (IARs). Urinary GAG (uGAG) levels, pulmonary function, oxygen dependence, CO2 levels, cardiac valve function, liver and spleen size, and growth velocity were assessed to evaluate response to therapy. rhGUS infusions were well tolerated. No serious adverse events (SAEs) or IARs were observed. After initiation of rhGUS infusions, the patient's uGAG excretion decreased by more than 50%. Liver and spleen size were reduced within 2weeks of the first infusion and reached normal size by 24weeks. Pulmonary function appeared to improve during the course of treatment based on reduced changes in ETCO2 after off-ventilator challenges and a reduced oxygen requirement. The patient regained the ability to eat orally, gained weight, and his energy and activity levels increased. Over 24weeks, treatment with every-other-week infusions of rhGUS was well tolerated with no SAEs, IARs, or hypersensitivity reactions and was associated with measurable improvement in objective clinical measures and quality of life. PMID:25468648

  18. Monopolar Spindle 1 (MPS1) Kinase Promotes Production of Closed MAD2 (C-MAD2) Conformer and Assembly of the Mitotic Checkpoint Complex*

    Science.gov (United States)

    Tipton, Aaron R.; Ji, Wenbin; Sturt-Gillespie, Brianne; Bekier, Michael E.; Wang, Kexi; Taylor, William R.; Liu, Song-Tao

    2013-01-01

    MPS1 kinase is an essential component of the spindle assembly checkpoint (SAC), but its functioning mechanisms are not fully understood. We have shown recently that direct interaction between BUBR1 and MAD2 is critical for assembly and function of the human mitotic checkpoint complex (MCC), the SAC effector. Here we report that inhibition of MPS1 kinase activity by reversine disrupts BUBR1-MAD2 as well as CDC20-MAD2 interactions, causing premature activation of the anaphase-promoting complex/cyclosome. The effect of MPS1 inhibition is likely due to reduction of closed MAD2 (C-MAD2), as expressing a MAD2 mutant (MAD2L13A) that is locked in the C conformation rescued the checkpoint defects. In the presence of reversine, exogenous C-MAD2 does not localize to unattached kinetochores but is still incorporated into the MCC. Contrary to a previous report, we found that sustained MPS1 activity is required for maintaining both the MAD1·C-MAD2 complex and open MAD2 (O-MAD2) at unattached kinetochores to facilitate C-MAD2 production. Additionally, mitotic phosphorylation of BUBR1 is also affected by MPS1 inhibition but seems dispensable for MCC assembly. Our results support the notion that MPS1 kinase promotes C-MAD2 production and subsequent MCC assembly to activate the SAC. PMID:24151075

  19. The Systems Development Dilemma: Whether to Adopt Formalised Systems Development Methodologies or Not?

    OpenAIRE

    Fitzgerald, Brian

    1994-01-01

    Systems development issues occupy a position of central imponance in the information systems field and, indeed.. much has been prescribed in the quest for successful systems development. However. given the well· documented Msoftwarc: crisis", success is far from guaranteed for many systems development projects. Many researchers see the solution to the software crisis in terms of increased control and the morc widespread adoption of rigorous and formalised system development metho...

  20. Development and social security system sustainability

    OpenAIRE

    Burz, Ra?zvan-dorin

    2012-01-01

    In this paper we propose to investigate the link between economic development, social security system and the sustainability of the policies pursued by states. In doing so, we start from clarifying and summarizing the main ideas on the concepts of development and social security. Depending on the approach to social security (narrow or broad) and the developing status of the states (developed or developing) we propose a matrix of classification and analysis that can offer new perspectives on d...

  1. Development of hydrogen safety system

    International Nuclear Information System (INIS)

    Effective way of protection against propagation of hazards (for instance, leaks) is neutralization of dangerous hydrogen-air mixtures by a method of controlled catalytic combustion inside special devices, so-called recombiners. The aim of this paper is development of hydrogen detectors and hydrogen catalytic recombiners based on high porosity cell material (HPCM). Experimental and theoretical studies of hydrogen combustion processes, heat- and mass transfer in catalytic-activated HPCM, allowed for a design optimization of recombiners and detectors and their location. Pilot hydrogen detectors and hydrogen catalytic recombiners were fabricated and their laboratory tests were successfully performed. (authors)

  2. Solar heating and cooling systems design and development. [prototype development

    Science.gov (United States)

    1977-01-01

    The development of twelve prototype solar heating/cooling systems, six heating and six heating and cooling systems, two each for single family, multi-family, and commercial applications, is reported. Schedules and technical discussions, along with illustrations on the progress made from April 1, 1977 through June 30, 1977 are detailed.

  3. Development of Architectures for Internet Telerobotics Systems

    OpenAIRE

    Bambang, Riyanto

    2008-01-01

    This paper presents our experience in developing and implementing Internet telerobotics system. Internet telerobotics system refers to a robot system controlled and monitored remotely through the Internet. A robot manipulator with five degrees of freedom, called Mentor, is employed. Client-server architecture is chosen as a platform for our Internet telerobotics system. Three generations of telerobotics systems have evolved in this research. The first generation was based on...

  4. Development of Environmental Radiation Monitoring System

    Energy Technology Data Exchange (ETDEWEB)

    Choi, S.S.; Oh, G.H.; Chang, T.W.; Jang, T.I. [Korea Electric Power Research Institute, Taejeon (Korea, Republic of); Lee, K.H.; Ha, D.K.; Jung, Y.J.; Ro, W.Y.; Shin, D.Y.; Jang, S.B.; Shin, H.M.; Cho, H.S. [Electrical Engineering and Science Research Institute, Seoul (Korea, Republic of)

    1997-12-31

    This paper is a final report of the research project which is development of environmental radiation monitoring system(ERMS) for nuclear power plant(NPP) area. It contains -Analysis and design for the developments of ERMS -Study on radiation monitoring systems and Environmental radiation detection methods -H/W development : Counter and ion interface, Dose conversion unit, Single channel analyzer, Microprocessor controller -S/W development : Communication, Control, and Operation program - And the performance analysis and test results of the system for Kori NPP operation. (author). 48 refs., 19 figs., 22 tabs.

  5. Testing Infrastructure for Operating System Kernel Development

    DEFF Research Database (Denmark)

    Walter, Maxwell; Karlsson, Sven

    2014-01-01

    Testing is an important part of system development, and to test effectively we require knowledge of the internal state of the system under test. Testing an operating system kernel is a challenge as it is the operating system that typically provides access to this internal state information. Multi-core kernels pose an even greater challenge due to concurrency and their shared kernel state. In this paper, we present a testing framework that addresses these challenges by running the operating system in a virtual machine, and using virtual machine introspection to both communicate with the kernel and obtain information about the system. We have also developed an in-kernel testing API that we can use to develop a suite of unit tests in the kernel. We are using our framework for for the development of our own multi-core research kernel.

  6. Development of Residential SOFC Cogeneration System

    Energy Technology Data Exchange (ETDEWEB)

    Ono, Takashi; Miyachi, Itaru [KYOCERA CORPORATION, R and D Center, Kagoshima, 1-4, Yamashita-cho, Kokubu, Kirishima-shi, Kagoshima (Japan); Suzuki, Minoru; Higaki, Katsuki, E-mail: takashi.ono.cy@kyocera.jp [OSAKA GAS Co., Ltd., Fuel Cell Development Department, 6-19-9, Torishima, Konohana-ku, Osaka (Japan)

    2011-06-15

    Since 2001 Kyocera has been developing 1kW class Solid Oxide Fuel Cell (SOFC) for power generation system. We have developed a cell, stack, module and system. Since 2004, Kyocera and Osaka Gas Co., Ltd. have been developed SOFC residential co-generation system. From 2007, we took part in the 'Demonstrative Research on Solid Oxide Fuel Cells' Project conducted by New Energy Foundation (NEF). Total 57 units of 0.7kW class SOFC cogeneration systems had been installed at residential houses. In spite of residential small power demand, the actual electric efficiency was about 40%(netAC,LHV), and high CO2 reduction performance was achieved by these systems. Hereafter, new joint development, Osaka Gas, Toyota Motors, Kyocera and Aisin Seiki, aims early commercialization of residential SOFC CHP system.

  7. Doing learning : engineers in systems development

    DEFF Research Database (Denmark)

    Mathiasen, John Bang; Koch, Christian

    Purpose: To investigate how learning occurs in a systems development project, using a company developing wind turbine control systems in collaboration with customers as case. Design/methodology/approach: Dewey’s approach to learning is used, emphasising reciprocity between the individual’s experience and the sociotechnical practice. The framework involves the concepts of sociotechnical practice, anchoring of indeterminate situation, and strip of doings towards determinate situation. An ethnographic study was made of four cases of systems development. Findings: An extreme case reveals initiated learning processes and that the interchanges between materiality and systems developers block the learning processes due to a customer with imprecise demands and unclear system specifications. In the four cases discussed, learning does occur however. Research limitations/implications: A qualitative study focusing on individual systems developers gives limited insight into whether the learning processes found would occur in other systems development processes. Practical implications: Managers should ensure that constitutive means, such as specifications, are available, and that they are sufficiently obdurate. Too ductile means, such as customers with unclear demands, can block learning processes. Systems developers with different experience also enable learning processes. Converging anchoring of the indeterminate situation being handled enables collective learning. Focusing on this, systems development companies can safeguard their learning and product embedded knowledge when engaging in interorganisational collaboration handling the risk of giving knowledge away. Originality/value: The specific contribution involves Dewey’s approach to learning with focus on micro-processes of the individual systems developer’s learning, adding the possibility for collective learning.

  8. Management Planning for Library Systems Development

    OpenAIRE

    Bellomy, Fred L.

    2013-01-01

    This paper deals with the application to library systems development programs of planning techniques which long ago proved their usefulness in business, military, and aerospace developments. The significant features of PERT (Program Evaluation and Review Technique), WBS (Work Breakdown Structure), planning diagrams, statements of work, cost/time estimates, schedules, manpower loading, and cost phasing are related through an example to the management requirements of a mafor systems development...

  9. Developing Sustainable Life Support System Concepts

    Science.gov (United States)

    Thomas, Evan A.

    2010-01-01

    Sustainable spacecraft life support concepts may allow the development of more reliable technologies for long duration space missions. Currently, life support technologies at different levels of development are not well evaluated against each other, and evaluation methods do not account for long term reliability and sustainability of the hardware. This paper presents point-of-departure sustainability evaluation criteria for life support systems, that may allow more robust technology development, testing and comparison. An example sustainable water recovery system concept is presented.

  10. Development of high vacuum systems at ICIS

    International Nuclear Information System (INIS)

    This paper is a review of the high vacuum technologies developed at the Institute of Cryogenics and Isotope Separations. Based on studies of gas dynamics, molecular flow and low temperature physics there were developed turbomolecular and cryogenic pumps. Also, developments in high vacuum measurements and control systems for pressures as low as 10-8 Torr are presented

  11. Development of energy harvester system for avionics

    Science.gov (United States)

    Hadas, Z.; Vetiska, V.; Ancik, Z.; Ondrusek, C.; Singule, V.

    2013-05-01

    This paper deals with an energy harvesting system for avionics; it is an energy source for a unit which is used for wireless monitoring or autonomous control of a small aircraft engine. This paper is focused on development process of energy harvesting system from mechanical vibrations in the engine area. The used energy harvesting system consists of an electro-magnetic energy harvester, power management and energy storage element. The energy harvesting system with commercial power management circuits have to be tested and verified measured results are used for an optimal redesign of the electro-magnetic harvester. This developmental step is necessary for the development of the optimal vibration energy harvesting system.

  12. Developing a Computerized Multicampus Transfer Information System.

    Science.gov (United States)

    Rubin, Larry; And Others

    1995-01-01

    Origins and development of a computerized credit transfer system for students in the University of Wisconsin system is described. The program will become the official course equivalency and degree requirement schema for the university, and will also serve the Wisconsin Technical College system. (Author/MSE)

  13. Developing DB system of piping reliability

    International Nuclear Information System (INIS)

    Developing DB system of piping reliability including the population data and service history of damaged piping for pilot power plant. Total weld counts of shop welds, field welds and welds for measuring instruments for 14 systems of Kori unit 3. Total weld counts of shop welds, field welds and welds for measuring instruments for 12 systems of Wolsung unit 2

  14. New developments in multi-meson systems

    Energy Technology Data Exchange (ETDEWEB)

    W. Detmold, B. Smigielski

    2010-06-01

    New developments in the study of multi-meson systems are reviewed. We highlight a new recursive algorithm for generating the requisite contractions needed for studying complex systems of mesons involving large numbers of particles or multiple species of particles. First results on mixed species systems involving pions and kaons are also presented.

  15. Safeguards -Safeguards system development support-

    International Nuclear Information System (INIS)

    This project mainly focused to technically support national safeguards inspection which is scheduled in the beginning of 1997. It includes non-destructive assay of nuclear fuels, analysis on inspection and environmental samples, remote monitoring of nuclear activities and its analysis, survey on remote sensing of satellite for safeguards application. Non-destructive assay of nuclear fuels dealt with development on verification of spent fuels with emphasis to fabrication of inspection tools with surveillance and gamma measurement on CANDU spent fuels. For sample analysis, study was carried out on process inspection sample analysis method. In addition to this, ultra low background laboratory was set up to execute environmental and swipe samples and sample treatment techniques including water, soil, plant, et al. were researched. Tritiums which were sampled around power plants were analysed. With cooperation of Satellite Technology Research Center of KAIST, use of civilian satellite imagery was surveyed. To train facility operators for safeguards, various technology on non-destructive assay was lectured to personnel of Korea Electric Power Corporation. And to enhance out capabilities, non-destructive assay training was done at Los Alamos National Lab. of U.S. through the agreement of MOST and DOE agreement, and information on DA technology was exchanged at Nuclear Material Control Center of Japan. (author). 22 tabs., 52 figs., 53 refs

  16. Development of sorting system control using LABVIEW

    International Nuclear Information System (INIS)

    The development of the Personnel Dosimeter Sorting System, proposed by the Secondary Standard Dosimetry Laboratory (SSDL) is to enhance the system or work flow in preparing the personnel dosimeter. The main objective of the system is to reduce stamping error, time and cost. The Personnel Dosimeter Sorting System is a semi-automatic system with an interfacing method using the Advantec 32 bit PCI interface card of 64 digital input and output. The system is integrated with the Labview version 7.1 programming language to control the sorting system and operation. (Author)

  17. Development of the Digital Reactor Safety System

    International Nuclear Information System (INIS)

    Objectives of Project - Development of Digital Safety Grade PLC and Licensing - Development of Safety System(RPS) and Licensing - Development of Safety System(ESF-CCS) and Licensing Content and Result of Project - POSAFE-Q PLC : Development of PLC platform for Shin-UCN unit 1 and 2 ·Development Scope : Processor module, Power module, 3 kinds of Communication module, Bus extension module(Master and Slave), 16 kinds of Input and Output module ·PLC application software development tool(pSET) - IDiPS RPS and IDiPS ESF-CCS : Development of PPS for Sin-UCN 1 and 2 ·Development Scope - 4-channels RPS with the KNICS inherent architecture - A part of 1-channels ESF-CCS with the KNICS inherent architecture - Licensing ·optical Report Submitted and Expected to finish the licensing process until Aug. 2008

  18. System model development for nuclear thermal propulsion

    International Nuclear Information System (INIS)

    A critical enabling technology in the evolutionary development of nuclear thermal propulsion (NTP) is the ability to predict the system performance under a variety of operating conditions. Since October 1991, US (DOE), (DOD) and NASA have initiated critical technology development efforts for NTP systems to be used on Space Exploration Initiative (SEI) missions to the Moon and Mars. This paper presents the strategy and progress of an interagency NASA/DOE/DOD team for NTP system modeling. It is the intent of the interagency team to develop several levels of computer programs to simulate various NTP systems. An interagency team was formed for this task to use the best capabilities available and to assure appropriate peer review. The vision and strategy of the interagency team for developing NTP system models will be discussed in this paper. A review of the progress on the Level 1 interagency model is also presented

  19. A Software Development Platform for Mechatronic Systems

    DEFF Research Database (Denmark)

    Guan, Wei

    2012-01-01

    Software has become increasingly determinative for development of mechatronic systems, which underscores the importance of demands for shortened time-to-market, increased productivity, higher quality, and improved dependability. As the complexity of systems is dramatically increasing, these demands present a challenge to the practitioners who adopt conventional software development approach. An effective approach towards industrial production of software for mechatronic systems is needed. This approach requires a disciplined engineering process that encompasses model-driven engineering and component-based software engineering, whereby we enable incremental software development using component models to address the essential design issues of real-time embedded systems. To this end, this dissertation presents a software development platform that provides an incremental model-driven development process based on a component-based modeling framework and a number of component-based analysis methods. The framework offers modeling languages for specifying the system, functional components, runtime environment, and platform. Furthermore, the defined compositional and relational rules of these component models enable rigorous construction of systems. The incremental development process separates the development activities into prefabrication of reusable components, conguration and generation of applications using validated components, and elimination of design errors using model-based analysis and verfication methods. Especially, the latter methods employ appropriate techniques and tools for dierent aspects of design issues. Finally, the tool-chain supporting these technology is evaluated comparatively to validate the proposed methods and identify the advantages and disadvantages of the technologies developed in this work.

  20. SNAP reactor reflector control systems development

    International Nuclear Information System (INIS)

    The Systems for Nuclear Auxiliary Power (SNAP) reactor reflector control systems have been reviewed for near-term use of the reflector control technology developed during the SNAP space reactor program. The launch and operating environment for which the SNAP reflector control systems were designed is discussed. System design and operation for each of the SNAP reactor control systems are discussed. Major component design and development work, as well as the reactor system and individual component testing are summarized. The reactor control system technology is directly applicable to SNAP-DYN, the latest uranium-zirconium hydride space reactor design. This control system technology is truly state of the art for use in future military and civilian space power programs

  1. Space Launch Flight Termination System initial development

    Science.gov (United States)

    Ratkevich, B.; Brierley, S.; Lupia, D.; Leiker, T.

    This paper describes the studies, capabilities and challenges in initial development of a new digital encrypted termination system for space launch vehicles. This system is called the Space Launch Flight Termination System (SLFTS). Development of SLFTS is required to address an obsolescence issue and to improve the security of flight termination systems presently in use on the nation's space launch vehicles. SLFTS development was implemented in a four phase approach with the goal of producing a high secure, cost effective flight termination system for United Launch Alliance (ULA) and the United States Air Force (USAF) Evolved Expendable Launch Vehicle (EELV). These detailed study phases developed the requirements, design and implementation approach for a new high secure flight termination system. Studies led to a cost effective approach to replace the High Alphabet Command Receiver Decoders (HA-CRD) presently used on the EELV (Delta-IV & Atlas-V), with a common SLFTS unit. SLFTS is the next generation flight termination system for space launch vehicles, providing an assured high secure command destruct system for launch vehicles in flight. The unique capabilities and challenges to develop this technology for space launch use will be addressed in this paper in detail. This paper summarizes the current development status, design and capabilities of SLFTS for EELV.

  2. System theoretic approach to sustainable development problems

    Directory of Open Access Journals (Sweden)

    Batanovi? Vladan

    2011-01-01

    Full Text Available This paper shows that the concepts and methodology contained in the system theory and operations research are suitable for application in the planning and control of the sustainable development. The sustainable development problems can be represented using the state space concepts, such as the transition of system, from the given initial state to the final state. It is shown that sustainable development represents a specific control problem. The peculiarity of the sustainable development is that the target is to keep the system in the prescribed feasible region of the state space. The analysis of planning and control problems of sustainable development has also shown that methods developed in the operations research area, such as multicriteria optimization, dynamic processes simulation, non-conventional treatment of uncertainty etc. are adequate, exact base, suitable for resolution of these problems.

  3. Development of intelligent operation control system

    International Nuclear Information System (INIS)

    Power Reactor and Nuclear Fuel Development Corp. participates in the developments of an intelligent operation control system (IOCS) and an intelligent maintenance control system (IMCS) for automatic operation and maintenance of nuclear power plant. The present situations and perspectives of these developments and researches were reviewed. In the period of 1991-1995, development of a prototype system for the assessment of the availability of IOCS ws tried and a plant diagnosis system based on a hierarchical function model and a control of plant operation according to a hierarchically operating strategy model were introduced. An object-oriented multi-agent system was applied to develop the IOCS consisting of subsystems in four levels and a man-machine interface able to display the operating conditions of those subsystems for operating managers was equipped to this system. The functions of each subsystem were evaluated by building block typed simulator. Aiming to construct some test systems we have a plan to materialize the processing algorithm and a system for each functional agent and also to establish a system to coordinate the respective agents. (M.N.)

  4. Development and application of earth system models

    OpenAIRE

    Prinn, Ronald G.

    2012-01-01

    The global environment is a complex and dynamic system. Earth system modeling is needed to help understand changes in interacting subsystems, elucidate the influence of human activities, and explore possible future changes. Integrated assessment of environment and human development is arguably the most difficult and most important “systems” problem faced. To illustrate this approach, we present results from the integrated global system model (IGSM), which consists of coupled submodels add...

  5. Development of environment radiation database management system

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Jong Gyu; Chung, Chang Hwa; Ryu, Chan Ho; Lee, Jin Yeong; Kim, Dong Hui; Lee, Hun Sun [Daeduk College, Taejon (Korea, Republic of)

    1999-03-15

    In this development, we constructed a database for efficient data processing and operating of radiation-environment related data. Se developed the source documents retrieval system and the current status printing system that supports a radiation environment dta collection, pre-processing and analysis. And, we designed and implemented the user interfaces and DB access routines based on WWW service policies on KINS Intranet. It is expected that the developed system, which organizes the information related to environmental radiation data systematically can be utilize for the accurate interpretation, analysis and evaluation.

  6. Systems Engineering Leadership Development: Advancing Systems Engineering Excellence

    Science.gov (United States)

    Hall, Phil; Whitfield, Susan

    2011-01-01

    This slide presentation reviews the Systems Engineering Leadership Development Program, with particular emphasis on the work being done in the development of systems engineers at Marshall Space Flight Center. There exists a lack of individuals with systems engineering expertise, in particular those with strong leadership capabilities, to meet the needs of the Agency's exploration agenda. Therefore there is a emphasis on developing these programs to identify and train systems engineers. The presentation reviews the proposed MSFC program that includes course work, and developmental assignments. The formal developmental programs at the other centers are briefly reviewed, including the Point of Contact (POC)

  7. Human iPSC-based Cardiac Microphysiological System For Drug Screening Applications.

    Science.gov (United States)

    Mathur, Anurag; Loskill, Peter; Shao, Kaifeng; Huebsch, Nathaniel; Hong, SoonGweon; Marcus, Sivan G; Marks, Natalie; Mandegar, Mohammad; Conklin, Bruce R; Lee, Luke P; Healy, Kevin E

    2015-01-01

    Drug discovery and development are hampered by high failure rates attributed to the reliance on non-human animal models employed during safety and efficacy testing. A fundamental problem in this inefficient process is that non-human animal models cannot adequately represent human biology. Thus, there is an urgent need for high-content in vitro systems that can better predict drug-induced toxicity. Systems that predict cardiotoxicity are of uppermost significance, as approximately one third of safety-based pharmaceutical withdrawals are due to cardiotoxicty. Here, we present a cardiac microphysiological system (MPS) with the attributes required for an ideal in vitro system to predict cardiotoxicity: i) cells with a human genetic background; ii) physiologically relevant tissue structure (e.g. aligned cells); iii) computationally predictable perfusion mimicking human vasculature; and, iv) multiple modes of analysis (e.g. biological, electrophysiological, and physiological). Our MPS is able to keep human induced pluripotent stem cell derived cardiac tissue viable and functional over multiple weeks. Pharmacological studies using the cardiac MPS show half maximal inhibitory/effective concentration values (IC50/EC50) that are more consistent with the data on tissue scale references compared to cellular scale studies. We anticipate the widespread adoption of MPSs for drug screening and disease modeling. PMID:25748532

  8. Development of maintainability index for mechanical systems

    Energy Technology Data Exchange (ETDEWEB)

    Wani, M.F.; Gandhi, O.P

    1999-09-01

    A procedure based on a digraph and matrix method is developed for evaluation of maintainability index of mechanical systems. Features which characterize or ease in maintenance of a system are identified and are called the maintainability attributes. Consideration of these attributes and their interrelations are rudiment in evaluating the index. This is modeled in terms of a Maintainability Attributes Digraph for the system. Nodes in the digraph represent these attributes and their interrelations are represented by the edges. The digraph is represented by one-to-one matrix for development of a maintainability expression, which is characteristic of the system. A Variable Maintainability Attributes Facilitation Permanent Matrix is defined to develop maintainability expression (VPF-m) which is also useful in comparing two systems. Maintainability Index of the system is obtained from the permanent of the matrix or from the maintainability expression by substituting numerical values of the attributes and their interrelations. A higher value of the index implies good maintainability of the system. The ideal value of maintainability index (I{sub mi}) is also obtained from the matrix expression, which is useful in assessing relative maintainability, I{sub r}, of the system alternative. The procedure is useful in design and development of maintainable systems. A step by step procedure for evaluation of maintainability index is also suggested and is illustrated by means of an example.

  9. Development of radiation detection and measurement systems - Development of industrial CT system using radiation

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jeong Ki; Lee, Sung Sik; Lim, Sung Jin; Kim, Un Ki; Kwon, Jin O [Korea Inspection and Engineering Co. Ltd., Seoul (Korea)

    2000-03-01

    It needs proper quality inspection systems to develop various industries and it is possible to prevent big accidents by precise inspection to component of industrial facilities. Computed tomography is one of the most precise nondestructive inspection system which enables us to know shape, size and location of flaw in the object. Therefore to develop the industrial computed tomography system, radiation collimators, a mechanical scanning system, hardware and software for automatic control were developed, which are important components of computed tomography. The developed system is applicable to radiometric system which can measure the remaining thickness of insulated pipe and deposit inside in it with real time. 14 refs., 26 figs., 3 tabs. (Author)

  10. Usability Factors in Information Systems Development

    Directory of Open Access Journals (Sweden)

    K. Chandra Sekharaiah

    2014-07-01

    Full Text Available Computers have become a commonplace technology for today’s man. Computer users demand more reliable and durable interfaces from information processing applications developers. Information systems (ISs research and development, over the years, has been steady so well that the arena has now grown into various subfields such as Cognitive Information Systems (CISs, Web Information Systems(WISs, Geographical Information Systems(GISs, Enterprise Information Systems (EISs, and so forth. Of late, ergonomics specialization too has begun to percolate into the field making it more cross-fertilizing with concerns for successful deployment, a win-win model of development and look-and-feel factor in terms of durable usage and usability. The paper presents a novel taxonomy of computer ergonomics.

  11. Development of Cooling System for Gyrotron Collector

    Science.gov (United States)

    Goswami, Uttam Kumar; Singh, Udaybir; Kumar, Nitin; Sahu, Naveen Kumar; Kumar, Anil; Yadav, Vivek; Kumar, Manoj; Khatun, Hasina; Dua, Rajeshwar Lal; Sinha, A. K.

    2013-08-01

    In this paper, the development of cooling system for 42 GHz, 200 kW gyrotron collector is presented. The design of the cooling duct has been finalized after different analyses such as, the fluid analysis, the thermal analysis, the structural analysis, etc. All analyses have been carried out by ANSYS software and the development of the cooling system based on the final design is performed.

  12. A sustainable system development method with applications

    OpenAIRE

    Wiryana, I. Made

    2009-01-01

    Sustainable development is a development that meets the needs of present generation while not compromising the ability of future generations to also meet their needs. There are 2 cases of sustainability. Case-1 is due to the discrepancy of environment and Case-2 is due to the change of environment. User, usage context and cultural aspects play important roles in the sustainability of system. Different groups of user response differently to the same system. Understanding the cultural consequen...

  13. Development of criticality safety evaluation system

    International Nuclear Information System (INIS)

    In 1980's, Japan Atomic Energy Research Institute developed a code system for criticality safety evaluation, JACS. It includes multi-group cross section library, MGCL, and Monte Carlo code, KENO-IV. To utilize a state of the art method of current criticality safety evaluation such as continuous energy Monte Carlo code, and to support evaluation activity by modern information technology, a plan for new development of criticality calculation code system will be launched soon. (author)

  14. Motor Development International: Compressed Air Technology Systems

    Science.gov (United States)

    How does a car that boasts "zero pollution" and even "cleans the air it uses" work? This website provides information on the air compression cars developed by Motor Development International. Aside from the general overview of the mechanics of air compression, the FAQ section provides additional information on the air tanks, filter system, body frame, electric system and MDI's business model. A key target for this website seems to be potential buyers and investors.

  15. Development of a simplified piping support system

    International Nuclear Information System (INIS)

    This paper presents the results of experimental and analytical studies for developing a simplified piping support system (SPSS) for nuclear power piping in place of snubbers. The basic concept of the SPSS is a passive seismic support system consisting of limit stops. Large gaps are provided to allow for free thermal expansion during normal plant operation while preventing excessive displacement during a seismic event. The results are part of a research and development program sponsored by EPRI. (orig./HP)

  16. Hydrogen storage and delivery system development: Fabrication

    Energy Technology Data Exchange (ETDEWEB)

    Handrock, J.L.; Malinowski, M.E.; Wally, K. [Sandia National Lab., Livermore, CA (United States)

    1996-10-01

    Hydrogen storage and delivery is an important element in effective hydrogen utilization for energy applications and is an important part of the FY1994-1998 Hydrogen Program Implementation Plan. This project is part of the Field Work Proposal entitled Hydrogen Utilization in Internal Combustion Engines (ICE). The goal of the Hydrogen Storage and Delivery System Development Project is to expand the state-of-the-art of hydrogen storage and delivery system design and development. At the foundation of this activity is the development of both analytical and experimental evaluation platforms. These tools provide the basis for an integrated approach for coupling hydrogen storage and delivery technology to the operating characteristics of potential hydrogen energy use applications. Analytical models have been developed for internal combustion engine (ICE) hybrid and fuel cell driven vehicles. The dependence of hydride storage system weight and energy use efficiency on engine brake efficiency and exhaust temperature for ICE hybrid vehicle applications is examined. Results show that while storage system weight decreases with increasing engine brake efficiency energy use efficiency remains relatively unchanged. The development, capability, and use of a newly developed fuel cell vehicle hydride storage system model will also be discussed. As an example of model use power distribution and control for a simulated driving cycle is presented. An experimental test facility, the Hydride Bed Testing Laboratory (HBTL) has been designed and fabricated. The development of this facility and its use in storage system development will be reviewed. These two capabilities (analytical and experimental) form the basis of an integrated approach to storage system design and development. The initial focus of these activities has been on hydride utilization for vehicular applications.

  17. INDUSTRIAL RESEARCH AND DEVELOPMENT INFORMATION SYSTEM (IRIS)

    Science.gov (United States)

    The National Science Foundation's (NSF) Industrial Research and Development Information System (IRIS) links an online interface to a historical database with more than 2,500 statistical tables containing all industrial research and development (R&D) data published by NSF since 19...

  18. Curriculum Development in History Using Systems Approach

    Science.gov (United States)

    Acun, Ramazan

    2011-01-01

    This work provides a conceptual framework for developing coherent history curricula at university level. It can also be used for evaluating existing curricula in terms of coherence. For this purpose, two models that are closely inter-connected called History Education System (Tarih Egitim Sistemi or TES) and History Research System (Tarih…

  19. Developing a Mobile Distance Learning System

    OpenAIRE

    Rogov, Petr; Borisov, Nikolay

    2007-01-01

    This article considers the basic problems of client-server electronic learning systems based on mobile platforms. Such questions as relational learning course model and student’s transitions prediction through the learning course items are considered. Besides, technical questions of electronic learning system “E-Learning Suite” realization and questions of developing portable applications using .NET Framework are discussed.

  20. Compass electrical systems development and commissioning

    International Nuclear Information System (INIS)

    The COMPASS machine is in the latter stages of construction and all the electrical and control systems have been installed. This paper covers the comprehensive development and commissioning programme including the testing of power supplies into dummy loads which is now complete. As a result Culham have confidence that reliable operation of the systems will be achieved. (author). 3 refs.; 3 figs

  1. Developments in power plant cooling systems

    International Nuclear Information System (INIS)

    A number of cooling systems are used in the power plants. The condenser cooling water system is one of the most important cooling systems in the plant. The system comprises a number of equipment. Plants using sea water for cooling are designed for the very high corrosion effects due to sea water. Developments are taking place in the design, materials of construction as well as protection philosophies for the various equipment. Power optimisation of the cycle needs to be done in order to design an economical system. Environmental (Protection) Act places certain limitations on the effluents from the plant. An attempt has been made in this paper to outline the developing trends in the various equipment in the condenser cooling water systems used at the inland as well as coastal locations. (author). 5 refs., 6 refs

  2. The Development of Computer Music Programming Systems

    OpenAIRE

    Lazzarini, Victor

    2013-01-01

    This article traces the history and evolution of Music Programming, from the early off-line synthesis programs of the MUSIC N family to modern realtime interactive systems. It explores the main design characteristics of these systems and their impact on Computer Music. In chronological fashion, the article will examine, with code examples, the development of the early systems into the most common modern languages currently in use. In particular, we will focus on Csound, highlighting its main ...

  3. Development of reactor core channel inspection system

    International Nuclear Information System (INIS)

    Inservice inspection of reactor coolant channels is essential to provide assurance of continued structural integrity of pressure tubes over reactor life. A channel inspection system (BARCIS) for inservice inspection of coolant channels of 235 MWe PHWRs has been developed. The system is designed with the aim to minimise radiation exposure to inspection personnel and to perform the inspection so as to minimise reactor downtime. Sixteen channels of RAPS-2 were recently inspected using BARCIS Mark I system. (author). 5 figs

  4. DEVELOPMENT OF INTELLIGENT SECURITY AND AUTOMATION SYSTEM

    OpenAIRE

    Diwakar Saxena, Puneet Bisen

    2012-01-01

    Intelligent security and Automation system is a device that intends to solve the security issues and also provides automation facilities. the two aspects of security and automation are distinguished by a selector switch. the goal is to develop an intelligent security & automation system that gives the user complete security and automation services. this system can work in two modes as indoor mode and outdoor mode. in outdoor mode it provides complete security of the user place and in indoor m...

  5. Natural history and galsulfase treatment in mucopolysaccharidosis VI (MPS VI, Maroteaux-Lamy syndrome)--10-year follow-up of patients who previously participated in an MPS VI Survey Study.

    Science.gov (United States)

    Giugliani, Roberto; Lampe, Christina; Guffon, Nathalie; Ketteridge, David; Leão-Teles, Elisa; Wraith, James E; Jones, Simon A; Piscia-Nichols, Cheri; Lin, Ping; Quartel, Adrian; Harmatz, Paul

    2014-08-01

    Mucopolysaccharidosis VI (MPS VI) is a clinically heterogeneous and progressive disorder with multiorgan manifestations caused by deficient N-acetylgalactosamine-4-sulfatase activity. A cross-sectional Survey Study in individuals (n?=?121) affected with MPS VI was conducted between 2001 and 2002 to establish demographics, urinary glycosaminoglycan (GAG) levels, and clinical progression of disease. We conducted a Resurvey Study (ClinicalTrials.gov: NCT01387854) to obtain 10-year follow-up data, including medical histories and clinical assessments (n?=?59), and survival status over 12 years (n?=?117). Patients received a mean (SD) of 6.8 (2.2) years of galsulfase ERT between baseline (Survey Study) and follow-up. ERT patients increased in height by 20.4 cm in the 4-7-year-old baseline age group and by 16.8 cm in the 8-12-year-old baseline age group. ERT patients 200 µg/mg baseline uGAG levels increased FVC by 48% in the ERT patients who completed the 6-min walk test demonstrated a mean (SD) increase of 65.7 (100.6) m. Cardiac outcomes did not significantly improve or worsen. Observed mortality rate among naïve patients was 50% (7/14) and 16.5% (17/103) in the ERT group (unadjusted hazard ratio, 0.24; 95% CI, 0.10-0.59). Long-term galsulfase ERT was associated with improvements in pulmonary function and endurance, stabilized cardiac function and increased survival. PMID:24764221

  6. Development of cask and transportation system

    International Nuclear Information System (INIS)

    The major goal of this project is to establish the safe transport system and obtain the necessary data for cask development by during research work for the design and safety test of shipping cask. The analysis technique using computer code for design has been studied in the field of structure, thermal and shielding analysis in this study. And also the test and measurement technology was developed for the measuring system of drop and fire test. It is expected that research activity ensured in this job will enable us to ultilize the basic data for the cask development. (Author)

  7. development of new dosimetry system using alanine

    International Nuclear Information System (INIS)

    The application of nuclear technology in several industrial fields (food, pharmaceutical, biological,), including sterilization of para-pharmaceutical use and conservation of food irradiation, is becoming more widespread during the last decade. Alongside the development of ionization techniques, the development of dosimetry systems for simple routine use is necessary. The aim of this master project is to develop a new dosimetry system for secondary high-performance control radiation doses applied to different matrices, using the spectrophotometric technique as an alternative of the electron paramagnetic resonance spectroscopy (ESR).

  8. [Therapy for systemic metabolic disorders based on the detection of basic corneal landmarks in childhood].

    Science.gov (United States)

    Lisch, W; Pitz, S; Geerling, G

    2013-06-01

    Many systemic lysosomal storage disorders show basic corneal opacities already in childhood. The lysosome is a cell organelle, produced by Golgi's apparatus, that is surrounded by a membrane and contains hydrolytic enzymes that break down food molecules, especially proteins and other complex molecules. The ophthalmologist's precise diagnosis of corneal clouding at the slit-lamp may reveal the correct interpretation of the specific lysosomal storage disorder. It is very important to diagnose such diseases as soon as possible because today the development of systemic enzymatic therapies has broadened the therapeutic armamentarium for the current standard of care. The following corneal landmarks of systemic storage diseases and of the modern systemic therapy are presented: cornea verticillata in Fabry's disease, periodic infusion of alpha-galactosidase a; Kayser-Fleischer's ring in Wilson's disease, zinc, trienetin, low copper diet; multiple, punctiform crystals in cystinosis, cysteamine, Raptor RP 103(DR cysteamine) that reduces the cytotoxity in form of continous dissolving of cystine from lysosome, renal transplantation, haematopoietic stem cell transplantation; peripheral ring, but not true lipid arc, and moderate stromal haze in LCAT-deficiency, injection of recombinant enzyme or of encapsulated LCAT-secreting cells; diffuse stromal haze in mucopolysaccharidoses (MPS). Enzyme replacement therapy is currently indicated for MPS I, MPS II, and MPS VI, haematopoietic stem cell transplantation; painful, bilateral pseudo-dendritic opacities in tyrosinemia type II (eponym: Richner-Hanhart syndrome), low phenylalanine and tyrosine diet result in complete disappearance of corneal alterations with a consecutive painfree period. Strict diet during the whole life is necessary to prevent corneal recurrences and the occurrence of palmo-plantar keratoses. Such therapies can enable the patient to lead an otherwise normal life for decades. PMID:23794426

  9. MODEL DRIVEN DEVELOPMENT OF ONLINE BANKING SYSTEMS

    Directory of Open Access Journals (Sweden)

    Bresfelean Vasile Paul

    2011-07-01

    Full Text Available In case of online applications the cycle of software development varies from the routine. The online environment, the variety of users, the treatability of the mass of information created by them, the reusability and the accessibility from different devices are all factors of these systems complexity. The use of model drive approach brings several advantages that ease up the development process. Working prototypes that simplify client relationship and serve as the base of model tests can be easily made from models describing the system. These systems make possible for the banks clients to make their desired actions from anywhere. The user has the possibility of accessing information or making transactions.

  10. Development of the simulation monitoring system

    Energy Technology Data Exchange (ETDEWEB)

    Kato, Katsumi [Research Organization for Information Science and Technology, Tokai, Ibaraki (Japan); Watanabe, Tadashi; Kume, Etsuo [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    2001-01-01

    Large-scale simulation technique is studied at the Center for Promotion of Computational Science and Engineering for the computational science research in nuclear fields. Visualization and animation processing techniques are developed for efficient understanding of simulation results. The development of the simulation monitoring system, which is used for real-time visualization of ongoing simulations or for successive visualization of calculated results, is described in this report. The standard visualization tool AVS5 or AVS/EXPRESS is used for the simulation monitoring system, and thus, this system can be utilized in various computer environments. (author)

  11. The HS6000/20 development system

    International Nuclear Information System (INIS)

    In the actual control system of MEA, NIKHEF-K three color displays are in use for graphical representation of the accelerator status information. At the moment the quality of the color displays is bad. The HS6000 development system of the English company Syntel seems to offer a possible solution to replace these displays. In the development system software is developed which finally may run on a target module. The target module, consisting of a processor card with memory and RS232 port and a graphical card, takes care for the control of a color display. The institute has disposed of an experimental set up during two weeks in order to investigate the possibilities and limitations of the development system. The HS6000 development system runs under the OS-9 multi-user and multi-tasking operating system. The operating system takes care for a part of the necessary software to render a computer valuable. The OS-9 operating system disposes of about 60 utility commands. A feature of OS-9 is the application of modular software technique which are based upon memory modules. The interface between the user and the internal functions of the operating system is formed from the shell, the OS-9 command-interpreter code. The software, which has to run on the target module, is written with the help of the Mmacs screen editor, the draw program and the medit editor. The draw program and the medit editor form part of the EGOS ( Enhanced Graphical Output Software) packet. The EGOS packet is a multi-tasking graphical interface for the OS-9 operating system. (author). 1 fig

  12. Development of pellet injection systems for ITER

    International Nuclear Information System (INIS)

    Oak Ridge National Laboratory (ORNL) has been developing innovative pellet injection systems for plasma fueling experiments on magnetic fusion confinement devices for about 20 years. Recently, the ORNL development has focused on meeting the complex fueling needs of the International Thermonuclear Experimental Reactor (ITER). In this paper, we describe the ongoing research and development activities that will lead to a ITER prototype pellet injector test stand. The present effort addresses three main areas: (1) an improved pellet feed and delivery system for centrifuge injectors, (2) a long-pulse (up to steady-state) hydrogen extruder system, and (3) tritium extruder technology. The final prototype system must be fully tritium compatible and will be used to demonstrate the operating parameters and the reliability required for the ITER fueling application

  13. System model development for nuclear thermal propulsion

    International Nuclear Information System (INIS)

    A critical enabling technology in the evolutionary development of nuclear thermal propulsion (NTP) is the ability to predict the system performance under a variety of operating conditions. This is crucial for mission analysis and for control subsystem testing as well as for the modeling of various failure modes. Performance must be accurately predicted during steady-state and transient operation, including startup, shutdown, and post operation cooling. The development and application of verified and validated system models has the potential to reduce the design, testing, and cost and time required for the technology to reach flight-ready status. Since Oct. 1991, the U.S. Department of Energy (DOE), Department of Defense (DOD), and NASA have initiated critical technology development efforts for NTP systems to be used on Space Exploration Initiative (SEI) missions to the Moon and Mars. This paper presents the strategy and progress of an interagency NASA/DOE/DOD team for NTP system modeling. It is the intent of the interagency team to develop several levels of computer programs to simulate various NTP systems. The first level will provide rapid, parameterized calculations of overall system performance. Succeeding computer programs will provide analysis of each component in sufficient detail to guide the design teams and experimental efforts. The computer programs will allow simulation of the entire system to allow prediction of the integrated performance. An interagency he integrated performance. An interagency team was formed for this task to use the best capabilities available and to assure appropriate peer review

  14. Proximity sensor system development. CRADA final report

    Energy Technology Data Exchange (ETDEWEB)

    Haley, D.C. [Oak Ridge National Lab., TN (United States); Pigoski, T.M. [Merrit Systems, Inc. (United States)

    1998-01-01

    Lockheed Martin Energy Research Corporation (LMERC) and Merritt Systems, Inc. (MSI) entered into a Cooperative Research and Development Agreement (CRADA) for the development and demonstration of a compact, modular proximity sensing system suitable for application to a wide class of manipulator systems operated in support of environmental restoration and waste management activities. In teleoperated modes, proximity sensing provides the manipulator operator continuous information regarding the proximity of the manipulator to objects in the workspace. In teleoperated and robotic modes, proximity sensing provides added safety through the implementation of active whole arm collision avoidance capabilities. Oak Ridge National Laboratory (ORNL), managed by LMERC for the United States Department of Energy (DOE), has developed an application specific integrated circuit (ASIC) design for the electronics required to support a modular whole arm proximity sensing system based on the use of capacitive sensors developed at Sandia National Laboratories. The use of ASIC technology greatly reduces the size of the electronics required to support the selected sensor types allowing deployment of many small sensor nodes over a large area of the manipulator surface to provide maximum sensor coverage. The ASIC design also provides a communication interface to support sensor commands from and sensor data transmission to a distributed processing system which allows modular implementation and operation of the sensor system. MSI is a commercial small business specializing in proximity sensing systems based upon infrared and acoustic sensors.

  15. Proximity sensor system development. CRADA final report

    International Nuclear Information System (INIS)

    Lockheed Martin Energy Research Corporation (LMERC) and Merritt Systems, Inc. (MSI) entered into a Cooperative Research and Development Agreement (CRADA) for the development and demonstration of a compact, modular proximity sensing system suitable for application to a wide class of manipulator systems operated in support of environmental restoration and waste management activities. In teleoperated modes, proximity sensing provides the manipulator operator continuous information regarding the proximity of the manipulator to objects in the workspace. In teleoperated and robotic modes, proximity sensing provides added safety through the implementation of active whole arm collision avoidance capabilities. Oak Ridge National Laboratory (ORNL), managed by LMERC for the United States Department of Energy (DOE), has developed an application specific integrated circuit (ASIC) design for the electronics required to support a modular whole arm proximity sensing system based on the use of capacitive sensors developed at Sandia National Laboratories. The use of ASIC technology greatly reduces the size of the electronics required to support the selected sensor types allowing deployment of many small sensor nodes over a large area of the manipulator surface to provide maximum sensor coverage. The ASIC design also provides a communication interface to support sensor commands from and sensor data transmission to a distributed processing system which allows modular implementation and operation of the sensor system. MSI is a commercial small business specializing in proximity sensing systems based upon infrared and acoustic sensors

  16. Toward a Cooperative Experimental System Development Approach

    DEFF Research Database (Denmark)

    GrØnbæk, Kaj; Kyng, Morten

    1997-01-01

    This chapter represents a step towards the establishment of a new system development approach, called Cooperative Experimental System Development (CESD). CESD seeks to overcome a number of limitations in existing approaches: specification oriented methods usually assume that system design can be based solely on observation and detached reflection; prototyping methods often have a narrow focus on the technical construction of various kinds of prototypes; Participatory Design techniques—including the Scandinavian Cooperative Design (CD) approaches—seldom go beyond the early analysis/design activities of development projects. In contrast, the CESD approach is characterized by its focus on: active user involvement throughout the entire development process; prototyping experiments closely coupled to work-situations and use-scenarios; transforming results from early cooperative analysis/design to targeted object oriented design, specification, and realisation; and design for tailorability. The emerging CESD approach is based on several years of experience in applying cooperative analysis and design techniques in projects developing general, tailorable software products. The CESD approach is, however, not limited to this development context, it may be applied for in-house or contract development as well. In system development, particularly in cooperative and experimental system development, we argue that it is necessary to analytically separate the abstract concerns, e.g. analysis, design, and realisation from concrete activities and techniques. Thus we introduce a CESD model which provides a framework for handling this separation and at the same time makes it possible to identify and discuss the rich variety of relationships among concrete activities and the main concerns.

  17. Development of a change management system

    Science.gov (United States)

    Parks, Cathy Bonifas

    1993-01-01

    The complexity and interdependence of software on a computer system can create a situation where a solution to one problem causes failures in dependent software. In the computer industry, software problems arise and are often solved with 'quick and dirty' solutions. But in implementing these solutions, documentation about the solution or user notification of changes is often overlooked, and new problems are frequently introduced because of insufficient review or testing. These problems increase when numerous heterogeneous systems are involved. Because of this situation, a change management system plays an integral part in the maintenance of any multisystem computing environment. At the NASA Ames Advanced Computational Facility (ACF), the Online Change Management System (OCMS) was designed and developed to manage the changes being applied to its multivendor computing environment. This paper documents the research, design, and modifications that went into the development of this change management system (CMS).

  18. Environmental development plan: geothermal energy systems

    Energy Technology Data Exchange (ETDEWEB)

    1979-08-01

    To ensure that environmental, health, and safety (EH and S) considerations are addressed adequately in the technology decision making process, the Environmental Development Plan (EDP) identifies and evaluates EH and S concerns; defines EH and S research and related assessments to examine or resolve the concerns; provides a coordinated schedule with the technology program for required EH and S research and developement; and indicates the timing for Environmental Assessments, Environmental Impact Statements, Environmental Readiness Documents, and Safety Analysis Reports. This EDP for geothermal energy systems covers all current and planned activities of the DOE Geothermal Energy Systems. Hydrothermal convection systems, geopressured systems, and hot-dry-rock systems are covered. Environmental concerns and requirements for resolution of these concerns are discussed at length. (MHR)

  19. Development of digital low level rf system

    International Nuclear Information System (INIS)

    One of the biggest advantages of the digital low level rf (LLRF) system is its flexibility. Owing to the recent rapid progress in digital devices (such as ADCs and DACs) and telecommunication devices (mixers and IQ modulators), digital LLRF system becomes popular in these 10 years. The J-PARC linac LLRF system adopted cPCI crates and FPGA based digital feedback system. Since the LLRF control of the normal conducting cavities are more difficult than super conducting cavities due to its lower Q values, fast processing using the FPGA was the essential to the feedback control. After the successful operation of J-PARC linac LLRF system, we developed the STF (ILC test facility in KEK) LLRF system. Since the klystron drives eight cavities in STF phase 1, we modified the FPGA board. Basic configuration and the performances of these systems are summarized. The future R and D projects (ILC and ERL) is also described from the viewpoints of LLRF. (author)

  20. ???????????? Evolutional Development of Library Information Systems

    Directory of Open Access Journals (Sweden)

    Hong-Chu Huang

    2010-06-01

    Full Text Available ???????????????????????????????,?????????,???????????????????????????,????????????????????????????????Google??????????????????????????,?????????,?????????????,????4?14??????,?????????????,?????????????????????????????????????????????????????????????????????12?????????????Library information systems are an essential tool for libraries to acquire and organize information resources to deliver services to users. With advancement of information technologies, library information systems have also evolved from card catalogue into diverse ones, such as integrated library system, elec- tronic resource management system, Amazon.com and Google Books. This article aims to review the historical development of library information systems as a basis to explore the future landscape of library information systems. Case study is adopted as research methodology to analyze fourteen library informa- tion systems. Furthermore, research findings and discussions are organized in the following points: type, granularity, boundary, organization and aggrega- tion of object, and representation of information resources, as well as software implementation, social OPAC, software design, operation model, and access.

  1. The Guided System Development Framework: Modeling and Verifying Communication Systems

    DEFF Research Database (Denmark)

    Carvalho Quaresma, Jose Nuno; Probst, Christian W.

    2014-01-01

    In a world that increasingly relies on the Internet to function, application developers rely on the implementations of protocols to guarantee the security of data transferred. Whether a chosen protocol gives the required guarantees, and whether the implementation does the same, is usually unclear. The Guided System Development framework contributes to more secure communication systems by aiding the development of such systems. The framework features a simple modelling language, step-wise refinement from models to implementation, interfaces to security verification tools, and code generation from the verified specification. The refinement process carries thus security properties from the model to the implementation. Our approach also supports verification of systems previously developed and deployed. Internally, the reasoning in our framework is based on the Beliefs and Knowledge tool, a verification tool based on belief logics and explicit attacker knowledge.

  2. Hydrogen storage and delivery system development

    Energy Technology Data Exchange (ETDEWEB)

    Handrock, J.L.; Wally, K.; Raber, T.N. [Sandia National Labs., Livermore, CA (United States)

    1995-09-01

    Hydrogen storage and delivery is an important element in effective hydrogen utilization for energy applications and is an important part of the FY1994-1998 Hydrogen Program Implementation Plan. The purpose of this project is to develop a platform for the engineering evaluation of hydrogen storage and delivery systems with an added focus on lightweight hydride utilization. Hybrid vehicles represent the primary application area of interest, with secondary interests including such items as existing vehicles and stationary uses. The near term goal is the demonstration of an internal combustion engine/storage/delivery subsystem. The long term goal is optimization of storage technologies for both vehicular and industrial stationary uses. In this project an integrated approach is being used to couple system operating characteristics to hardware development. A model has been developed which integrates engine and storage material characteristics into the design of hydride storage and delivery systems. By specifying engine operating parameters, as well as a variety of storage/delivery design features, hydride bed sizing calculations are completed. The model allows engineering trade-off studies to be completed on various hydride material/delivery system configurations. A more generalized model is also being developed to allow the performance characteristics of various hydrogen storage and delivery systems to be compared (liquid, activated carbon, etc.). Many of the features of the hydride storage model are applicable to the development of this more generalized model.

  3. An INTEL 8080 microprocessor development system

    International Nuclear Information System (INIS)

    The INTEL 8080 has become one of the two most widely used microprocessors at CERN, the other being the MOTOROLA 6800. Even thouth this is the case, there have been, to date, only rudimentary facilities available for aiding the development of application programs for this microprocessor. An ideal development system is one which has a sophisticated editing and filing system, an assembler/compiler, and access to the microprocessor application. In many instances access to a PROM programmer is also required, as the application may utilize only PROMs for program storage. With these thoughts in mind, an INTEL 8080 microprocessor development system was implemented in the Proton Synchrotron (PS) Division. This system utilizes a PDP 11/45 as the editing and file-handling machine, and an MSC 8/MOD 80 microcomputer for assembling, PROM programming and debugging user programs at run time. The two machines are linked by an existing CAMAC crate system which will also provide the means of access to microprocessor applications in CAMAC and the interface of the development system to any other application. (Auth.)

  4. Cryogenic Propellant Feed System Analytical Tool Development

    Science.gov (United States)

    Lusby, Brian S.; Miranda, Bruno M.; Collins, Jacob A.

    2011-01-01

    The Propulsion Systems Branch at NASA s Lyndon B. Johnson Space Center (JSC) has developed a parametric analytical tool to address the need to rapidly predict heat leak into propellant distribution lines based on insulation type, installation technique, line supports, penetrations, and instrumentation. The Propellant Feed System Analytical Tool (PFSAT) will also determine the optimum orifice diameter for an optional thermodynamic vent system (TVS) to counteract heat leak into the feed line and ensure temperature constraints at the end of the feed line are met. PFSAT was developed primarily using Fortran 90 code because of its number crunching power and the capability to directly access real fluid property subroutines in the Reference Fluid Thermodynamic and Transport Properties (REFPROP) Database developed by NIST. A Microsoft Excel front end user interface was implemented to provide convenient portability of PFSAT among a wide variety of potential users and its ability to utilize a user-friendly graphical user interface (GUI) developed in Visual Basic for Applications (VBA). The focus of PFSAT is on-orbit reaction control systems and orbital maneuvering systems, but it may be used to predict heat leak into ground-based transfer lines as well. PFSAT is expected to be used for rapid initial design of cryogenic propellant distribution lines and thermodynamic vent systems. Once validated, PFSAT will support concept trades for a variety of cryogenic fluid transfer systems on spacecraft, including planetary landers, transfer vehicles, and propellant depots, as well as surface-based transfer systems. The details of the development of PFSAT, its user interface, and the program structure will be presented.

  5. System Development as a Rational Communicative Process

    Directory of Open Access Journals (Sweden)

    Gert Veldhuijzen van Zanten

    2004-08-01

    Full Text Available System development is a process in which communication plays an important role. Requirements must be elicited from various stakeholders. But stakeholders also make decisions and must understand the consequences thereof. Different viewpoints must be reconciled, and agreements reached. An important assumption we make is that all actions in the development process are (or should be based on rational decisions. The quest for rationality is a driving force behind the communication that takes place within the development process, because it raises issues that may otherwise have remained in the subconsciousness of stakeholders. We zoom in on the role of vagueness in communication, and argue that there are good reasons not to try and formalize things too soon in the development process. The purpose of this paper is to position our ongoing research, encourage discussion about the assumptions we make, and inspire novel approaches to system development. We work towards a comprehensive theory of rational system development, in which due attention is paid to development processes, communication, and the representations used therein.

  6. Development of automated blender and dispensing system

    International Nuclear Information System (INIS)

    This paper describes automated blender and dispensing system designed and developed in Nuclear Recycle Board for its reprocessing plant. Obtaining sinterable grade oxide powder from the product solution received in the heavy metal product line involves skilled manpower and time consuming, laborious manual operations. Entire treatment is carried out in a train of closed containments called as glove boxes. In view of this Automated blender and dispensing system has been developed to reduce tedious manual operations. System consists of PLC based control system to drive motorised charging mechanism, a conical ribbon blender which homogenises the product and load cell triggered, indexing dispensing mechanism. Schematic design of the system has been done in-house, while fabrication was outsourced. System has been built, tested and installed at component test facility (CTF) at Tarapur. Actual blending tests were carried out by using dummy material like calcium carbonate and barium carbonate powder, with different sets of parameter. Blended product was chemically analysed for its homogeneity. System has now been put to trial runs by operating staff. This development has circumvented tedious operations of Scooping and increased the throughput. This paper describes challenges in undertaking this developmental work. (author)

  7. Development of industrial variant specification systems

    DEFF Research Database (Denmark)

    Hansen, Benjamin Loer

    2003-01-01

    With globalisation and increased competition industrial companies must be prepared to satisfy individual customer needs and still stay competitive with regards to lead times, quality, and prices. These factors require companies to be better prepared to handle specification activities during order acquisition and order fulfilment, i.e. the creation of drawings, bill-of-materials, routings, product descriptions, quote letters etc. The present thesis is rooted in the assumption that variant specification systems supporting the cross-functional processes of order acquisition and order fulfilment must be developed from a holistic and strategically anchored point of view. Another assumption is that this is a challenge for many industrial companies. Even though the literature presents many considerations on general issues covering new information technology, little work is found on the business perspectives and the challenge of understanding the variant specification tasks and the connections between variant specification, product development, sales, manufacturing, and information technology. The present thesis seeks to meet this challenge with a procedure, concepts and tools. This is done through an extensive answer to the four research tasks of the Ph.D. project: • Define and describe the variant specification system. • Create a procedure for the development of variant specification systems. • Create concepts, methods and tools to support the analysis and determination of the variant specification task. • Identify solution elements and structural variables to be used in the design of variant specification systems. The thesis presents a “top-down” procedure to be used to develop variant specification systems from a strategically anchored and holistic point of view. A methodology and related task variables are presented for analysing and determining the variant specification task. These are grouped in external and internal task variables. Additionally functional characteristics, which can be used for defining performance measures, are defined. Based in the concept of “focus” different levels of tasks are discussed. A list of structural variables and solution components has been created. These are related to four design aspects in the holistic system design covering the aspects of process design, selection of resources (such as hardware, software and humans), the design of information structures, and the design of organisational structures. The elements in the thesis have been created and evaluated through two case studies. Action research has been conducted in combination with the design and implementation of IT based variant specification systems. One of the case companies has successfully implemented highly advanced variant specification systems. In this company, the subject has been given a high strategic priority, and many new developers have been assigned to continue the development of such systems. In conclusion, the thesis presents a valuable platform for researchers and practitioners doing projects related to the development of variant specification systems.

  8. Fourth-generation photovoltaic concentrator system development

    Energy Technology Data Exchange (ETDEWEB)

    O`Neill, M.J.; McDanal, A.J. [ENTECH, Inc., Dallas-Fort Worth Airport, TX (United States)

    1995-10-01

    In 1991, under a contract with Sandia for the Concentrator Initiative, the ENTECH team initiated the design and development of a fourth-generation concentrator module. In 1992, Sandia also contracted with ENTECH to develop a new control and drive system for the ENTECH array. This report documents the design and development work performed under both contracts. Manufacturing processes for the new module were developed at the same time under a complementary PVMaT contract with the National Renewable Energy Laboratory. Two 100-kW power plants were deployed in 1995 in Texas using the newly developed fourth-generation concentrator technology, one at the CSW Solar Park near Ft. Davis and one at TUE Energy Park in Dallas. Technology developed under the Sandia contracts has made a successful transition from the laboratory to the production line to the field.

  9. A Systems Engineering Approach to Architecture Development

    Science.gov (United States)

    Di Pietro, David A.

    2015-01-01

    Architecture development is often conducted prior to system concept design when there is a need to determine the best-value mix of systems that works collectively in specific scenarios and time frames to accomplish a set of mission area objectives. While multiple architecture frameworks exist, they often require use of unique taxonomies and data structures. In contrast, this paper characterizes architecture development using terminology widely understood within the systems engineering community. Using a notional civil space architecture example, it employs a multi-tier framework to describe the enterprise level architecture and illustrates how results of lower tier, mission area architectures integrate into the enterprise architecture. It also presents practices for conducting effective mission area architecture studies, including establishing the trade space, developing functions and metrics, evaluating the ability of potential design solutions to meet the required functions, and expediting study execution through the use of iterative design cycles.

  10. Development of Constellation's Launch Control System

    Science.gov (United States)

    Lougheed, Kirk D.; Peaden, Cary J.

    2010-01-01

    The paper focuses on the National Aeronautics and Space Administration (NASA) Constellation Program's Launch Control System (LCS) development effort at Kennedy Space Center (KSC). It provides a brief history of some preceding efforts to provide launch control and ground processing systems for other NASA programs, and some lessons learned from those experiences. It then provides high level descriptions of the LCS mission, objectives, organization, architecture, and progress. It discusses some of our development tenets, including our use of standards based design and use of off-the-shelf products whenever possible, incremental development cycles, and highly reliable, available, and supportable enterprise class system servers. It concludes with some new lessons learned and our plans for the future.

  11. Performance Measurement System: recent systems development and applications

    Energy Technology Data Exchange (ETDEWEB)

    Rigney, R. A.

    1979-03-28

    The Performance Measurement System (PMS), a system for managing a given project or program, is described; this system incorporates the value earned for work accomplished approach. Development and application of this system is discussed under the following headings: PMS vs conventional management control systems; PMS implementation on a project/program; PMS data elements (organization, planning and budgeting, accounting, analysis, reports, and performance measurement data elements); recent PMS applications (FFTF, CRBRP, FMEF, and FMIT); and future of PMS. 25 references, 6 figures, 3 tables. (RWR)

  12. HAMMER COURSEWARE MANAGEMENT SYSTEM (CMS) SYSTEM DEVELOPMENT & IMPLEMENTATION

    Energy Technology Data Exchange (ETDEWEB)

    GARDNER, P.R.

    2006-04-28

    HAMMER Courseware Management System (HAMMERCMS) is the official name of the system Fluor Hanford, Inc., uses to facilitate development of, deliver, and track training presented in some electronic form (mainly, web-based training) to Hanford Site employees, subcontractors, and vendors.

  13. Development of Digitex premier digital angiographic systems

    Energy Technology Data Exchange (ETDEWEB)

    Miura, Yoshiaki; Miura, Yusuke; Goto, Keiichi; Imanishi, Tetsuo; Miyamoto, Wataru [Shimadzu Corp., Medical Systems Division, Kyoto (Japan)

    2003-06-01

    The technique of interventional radiology has come to be widely utilized in the field of angiography. This has brought forth a strong demand that digital angiographic systems provide high efficiency in patient examinations and high level of interventional support. This report refers to our newly developed Digitex Premier Series digital angiographic systems, designed to meet the above demands. The new systems utilize a high-speed, wide-range C-arm system, a high-resolution image intensifier, a fluid-lubricant X-ray tube, and a digital image processing system, in order to ensure high patient examination efficiency. Their IVR (interventional radiology)-Master bed-side image controller further enhances the efficiency of patient examinations, and also, their CAT (comfortable angio terminal) and FMC (file management console) improve the patient examination throughput and diagnostic workflow of the systems. (author)

  14. Progress of the TPS control system development

    International Nuclear Information System (INIS)

    The Taiwan Photon Source (TPS) is a low-emittance 3-GeV synchrotron light source that is being built at the National Synchrotron Radiation Research Center (NSRRC) campus. Control system for the TPS is based on EPICS (Experimental Physics and Industrial Control System) framework. Standard hardware and software components have been defined. Prototypes of various subsystems are in implementation. Event based timing system has been adopted. Power supply control interface accompany with orbit feedback support are also defined. Machine protection system is in design phase. Integration with the linear accelerator system which are installed and commissioned at the temporary site for acceptance test has been already done. Interface to various system are still in negotiate stage. Development of the infrastructure of high level and low level software are on going. Progress will be summarized in the report. (authors)

  15. Development of the Hypothalamic Melanocortin System

    Directory of Open Access Journals (Sweden)

    SebastienGBouret

    2013-03-01

    Full Text Available The melanocortin system is a critical component of the forebrain and hindbrain regulatory systems involved in energy balance. This system is composed of pro-opiomelanocortin (POMC neurons that act, in part, through the melanocortin-4 receptor (MC4R. Although the importance of the melanocortin system in controlling feeding has been established for two decades, the understanding of the developmental substrates underlying POMC and MC4R neuron development and function has just begun to emerge. The formation of the melanocortin system involves several discrete developmental steps that include the birth and fate specification of POMC- and MC4R-containing neurons and the extension and guidance of POMC axons to their MC4R-expressing target nuclei. Each of these developmental processes appears to require specific sets of genes and developmental cues that include perinatal hormones. Recent evidence has also highlighted the importance of perinatal nutrition in controlling the ultimate architecture of the melanocortin system.

  16. Controls system developments for the ERL facility

    International Nuclear Information System (INIS)

    The BNL Energy Recovery LINAC (ERL) is a high beam current, superconducting RF electron accelerator that is being commissioned to serve as a research and development prototype for a RHIC facility upgrade in view of a relativistic electron-ion collider (eRHIC). Key components of the machine include a laser, photocathode, and 5-cell superconducting RF cavity operating at a frequency of 703 MHz. Starting with a foundation based on an existing C++ Accelerator Device Object (ADO) based software running on both Linux servers and the VME/VxWorks platforms developed for RHIC, we are developing a controls system that incorporates a wide range of hardware Input/Output interfaces that are needed for machine development. Details of the system layout, specifications, and user interfaces are provided. (authors)

  17. Hydrogen storage and delivery system development: Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Handrock, J.L. [Sandia National Labs., Livermore, CA (United States)

    1996-10-01

    Hydrogen storage and delivery is an important element in effective hydrogen utilization for energy applications and is an important part of the FY1994-1998 Hydrogen Program Implementation Plan. This project is part of the Field Work Proposal entitled Hydrogen Utilization in Internal Combustion Engines (ICE). The goal of the Hydrogen Storage and Delivery System Development Project is to expand the state-of-the-art of hydrogen storage and delivery system design and development. At the foundation of this activity is the development of both analytical and experimental evaluation platforms. These tools provide the basis for an integrated approach for coupling hydrogen storage and delivery technology to the operating characteristics of potential hydrogen energy use applications. Results of the analytical model development portion of this project will be discussed. Analytical models have been developed for internal combustion engine (ICE) hybrid and fuel cell driven vehicles. The dependence of hydride storage system weight and energy use efficiency on engine brake efficiency and exhaust temperature for ICE hybrid vehicle applications is examined. Results show that while storage system weight decreases with increasing engine brake efficiency energy use efficiency remains relatively unchanged. The development, capability, and use of a recently developed fuel cell vehicle storage system model will also be discussed. As an example of model use, power distribution and control for a simulated driving cycle is presented. Model calibration results of fuel cell fluid inlet and exit temperatures at various fuel cell idle speeds, assumed fuel cell heat capacities, and ambient temperatures are presented. The model predicts general increases in temperature with fuel cell power and differences between inlet and exit temperatures, but under predicts absolute temperature values, especially at higher power levels.

  18. Mobile Systems Development: An Empirical Study

    OpenAIRE

    Hosbond, J. H.

    2005-01-01

    As part of an ongoing study on mobile systems development (MSD), this paper presents preliminary findings of research-in-progress. The debate on mobility in research has so far been dominated by mobile HCI, technological innovations, and socio-technical issues related to new and emerging mobile work patterns. This paper is about the development of mobile systems.Based on an on-going empirical study I present four case studies of companies each with different products or services to offer and ...

  19. The SLC control system - status and development

    International Nuclear Information System (INIS)

    The SLC control system is installed and operational in the full SLC through the Linac, Damping Rings, Positron Source, Arcs and Final Focus. The system now includes a host VAX 11/785, a development VAX 11/780, 4 VAX workstations, a distributed network of 70 microprocessors, and about 270 Camac crates with more than 4000 modules. The micros are used for control and monitoring of the hardware, for pulse-to-pulse feedback, and for consoles (COWs). High level model-driven host software provides a variety of tools for beam setup, optimization, diagnosis, and stabilization. This paper will summarize the current status and projects under development

  20. Modelling sustainable development of territorial production systems ????????????? ??????????? ???????? ??????????????? ???????????????? ??????

    Directory of Open Access Journals (Sweden)

    Pashkevich Marina S.

    2013-01-01

    Full Text Available The article provides an imitation model of stable development of territorial production systems, synthesised with the method of system dynamics, which, unlike the existing ones, has three basic levels – economic, ecological and social, takes into account cyclic fluctuations of external market situation in long-term and short-term periods, and is based on interrelation of stable territorial development with the innovation one. It substantiates structural and process approach to defining stable development, which lies in the basis of modelling and envisages establishment of a balance not only between static above-mentioned levels of territorial production systems, but also between those processes, which take place between these levels. It provides such a list of linear quantitative links between components of a territorial production system, so that in long-term prospective its development could be identified as stable with predominance of innovation production over resource intensive one. It makes a long-term forecast of development of the Dnipropetrivsk oblast on the basis of functioning of the proposed model.? ?????? ???????????? ???????????? ?????? ??????????? ???????? ??????????????? ???????????????? ??????, ??????????????? ??????? ????????? ????????, ???????, ? ??????? ?? ????????????, ????? ??? ???????? ?????? – ?????????????, ????????????? ? ??????????, ????????? ??????????? ????????? ??????????? ???????? ????? ? ???????????? ? ????????????? ????????, ????????? ?? ??????????? ??????????? ???????????????? ???????? ? ?????????????. ????????? ??????????-?????????? ?????? ? ??????????? ??????????? ????????, ??????? ??????? ? ?????? ????????????? ? ??????????????? ???????????? ??????? ?? ?????? ????? ???????????? ?????????????? ???????? ??????????????? ???????????????? ???????, ?? ? ???? ??????????, ??????? ?????????? ????? ????? ????????. ????????? ???????? ?????????????? ????? ????? ????????????? ??????????????? ???????????????? ??????? ????? ???????, ????? ? ???????????? ??????????? ?? ???????? ????? ???? ???????????????? ??? ?????????? ? ????????????? ?????????????? ???????????? ??? ????????????. ?? ?????? ???????????????? ???????????? ?????? ?????? ???????????? ??????? ???????? ???????????????? ???????.

  1. Development of steam injector feedwater heater system

    International Nuclear Information System (INIS)

    In order to realize the simplified BOP system of BWR plant, the authors developed the basic designs of feedwater system simplified by application of Steam Injector. Basic specification of simplified steam injector feedwater heater system (SI-FWH) was developed based on system designs and thermal efficiency evaluation. Test facility was constructed based on system specification selected in accordance with analysis results of plant thermal efficiency. The steam pressures used in the selected best system for low pressure feed water heaters are 0.05 MPa, 0.10 MPa, 0.21 MPa and 0.40 MPa are almost the same pressures as the current ABWR's. Improved steam injectors for feedwater heater system were studied by thermal hydraulic analyses and the test model attained the 1st and 2nd stage specifications. The 3rd and 4th stage injectors succeeded in raising the water temperature to 136degC. The parallel multistage steam injectors rationalize the feedwater system by eliminating the twelve neck-heaters, and prevent the chrome ion, which is dissolved from the stainless steel heater tube, introducing into the RPV. (author)

  2. Supporting production system development through Obeya concept

    OpenAIRE

    Shahbazi, Sasha; Javadi, Siavash

    2013-01-01

    Manufacturing Industry as an important part of European and Swedish economy faces new challenges with the daily growing global competition. An enabler of overcoming these challenges is a rapid transforming to a value-based focus. Investment in innovation tools for production system development is a crucial part of that focus which helps the companies to rapidly adapt their production systems to new changes. Those changes can be categorized to incremental and radical ones. In this research we ...

  3. Intrinsic Motivation Systems for Autonomous Mental Development

    OpenAIRE

    Oudeyer, Pierre-yves; Kaplan, Frederic; Hafner, Verena

    2007-01-01

    Exploratory activities seem to be intrinsicallyrewarding for children and crucial for their cognitive development. Can a machine be endowed with such an intrinsic motivation system? This is the question we study in this paper, presenting a number of computational systems that try to capture this drive towards novel or curious situations. After discussing related research coming from developmental psychology, neuroscience, developmental robotics and active learning, this article presents the m...

  4. Emergence of order in visual system development.

    OpenAIRE

    Shatz, C. J.

    1996-01-01

    Neural connections in the adult central nervous system are highly precise. In the visual system, retinal ganglion cells send their axons to target neurons in the lateral geniculate nucleus (LGN) in such a way that axons originating from the two eyes terminate in adjacent but nonoverlapping eye-specific layers. During development, however, inputs from the two eyes are intermixed, and the adult pattern emerges gradually as axons from the two eyes sort out to form the layers. Experiments indicat...

  5. A model for Business Intelligence SystemsDevelopment

    OpenAIRE

    Velicanu, Manole; Diaconita, Vlad; Lungu, Ion; Velicanu, Anda; Bara, Adela; Botha, Iuliana

    2009-01-01

    Often, Business Intelligence Systems (BIS) require historical data or data collected from var-ious sources. The solution is found in data warehouses, which are the main technology used to extract, transform, load and store data in the organizational Business Intelligence projects. The development cycle of a data warehouse involves lots of resources, time, high costs and above all, it is built only for some specific tasks. In this paper, we’ll present some of the aspects of the BI systems’...

  6. Recent Developments with the licas System

    OpenAIRE

    Greer, Kieran

    2014-01-01

    This paper describes recent developments with the licas (lightweight Internet-based communication for autonomic services) software package. In particular, it describes how the architecture and functionality have changed from the first version release. The autonomous nature of the system is focused on, which requires independent behaviour and metadata descriptions of each service. The system has now also been ported to the Java mobile environment. Then some open questions or ...

  7. Development of KSTAR Neutral Beam Heating System

    International Nuclear Information System (INIS)

    The prototype components of a neutral beam injection (NBI) system have been developed for the KSTAR, and a capability of the manufactured components has been tested. High power ion source, acceleration power supply, other ion source power supplies, neutralizer, bending magnet for ion beam separation, calorimeter, and cryo-sorption pump have been developed by using the domestic technologies and tested for a neutral beam injection of 8 MW per beamline with a pulse duration of 300 seconds. The developed components have been continuously upgraded to achieve the design requirements. The development technology of high power and long pulse neutral beam injection system has been proved with the achievement of 5.2 MW output for a short pulse length and 1.6 MW output for a pulse length of 300 seconds. Using these development technologies, the domestic NB technology has been stabilized under the development of high power ion source, NB beamline components, high voltage and current power supplies, NB diagnostics, NB system operation and control

  8. Development of KSTAR Neutral Beam Heating System

    Energy Technology Data Exchange (ETDEWEB)

    Oh, B. H.; Song, W. S.; Yoon, B. J. (and others)

    2007-10-15

    The prototype components of a neutral beam injection (NBI) system have been developed for the KSTAR, and a capability of the manufactured components has been tested. High power ion source, acceleration power supply, other ion source power supplies, neutralizer, bending magnet for ion beam separation, calorimeter, and cryo-sorption pump have been developed by using the domestic technologies and tested for a neutral beam injection of 8 MW per beamline with a pulse duration of 300 seconds. The developed components have been continuously upgraded to achieve the design requirements. The development technology of high power and long pulse neutral beam injection system has been proved with the achievement of 5.2 MW output for a short pulse length and 1.6 MW output for a pulse length of 300 seconds. Using these development technologies, the domestic NB technology has been stabilized under the development of high power ion source, NB beamline components, high voltage and current power supplies, NB diagnostics, NB system operation and control.

  9. Development of an automatic reactor inspection system

    International Nuclear Information System (INIS)

    Using recent technologies on a mobile robot computer science, we developed an automatic inspection system for weld lines of the reactor vessel. The ultrasonic inspection of the reactor pressure vessel is currently performed by commercialized robot manipulators. Since, however, the conventional fixed type robot manipulator is very huge, heavy and expensive, it needs long inspection time and is hard to handle and maintain. In order to resolve these problems, we developed a new automatic inspection system using a small mobile robot crawling on the vertical wall of the reactor vessel. According to our conceptual design, we developed the reactor inspection system including an underwater inspection robot, a laser position control subsystem, an ultrasonic data acquisition/analysis subsystem and a main control subsystem. We successfully carried out underwater experiments on the reactor vessel mockup, and real reactor ready for Ulchine nuclear power plant unit 6 at Dusan Heavy Industry in Korea. After this project, we have a plan to commercialize our inspection system. Using this system, we can expect much reduction of the inspection time, performance enhancement, automatic management of inspection history, etc. In the economic point of view, we can also expect import substitution more than 4 million dollars. The established essential technologies for intelligent control and automation are expected to be synthetically applied to the automation of similar systems in nuclear power plants

  10. Development of an omnidirectional vision system

    Scientific Electronic Library Online (English)

    Valdir, Grassi Junior; Jun, Okamoto Junior.

    2006-03-01

    Full Text Available SciELO Brazil | Language: English Abstract in english Omnidirectional vision systems can provide images with a 360° of field of view. For this reason, they can be useful to robotic applications such as navigation, teleoperation and visual servoing. An effective way to construct this type of vision system is by combining lenses and mirrors together resu [...] lting on a system that does not require the movement of the camera to the direction of attention of the robot. A typical construction is by mounting a convex mirror in front of a camera aligning the center of the mirror with the optical axis of the camera. The most common convex mirror shapes used are conic, parabolic, hyperbolic and spherical. In this work we present two types of mirror that were constructed: a spherical mirror, used in the initial tests, and a hyperbolic, used for actual robot tasks. The hyperbolic mirror was manufactured using an ultra-precision CNC machine. Additionally, a software was developed to create panoramic and perspective images from the image acquired by the system. This work shows the development of an omnidirectional vision system, presenting the formulation used to determine a suitable mirror shape, the mechanical solutions used to build a fully operational system, and the results of the developed algorithm.

  11. Development of an omnidirectional vision system

    Directory of Open Access Journals (Sweden)

    Valdir Grassi Junior

    2006-03-01

    Full Text Available Omnidirectional vision systems can provide images with a 360° of field of view. For this reason, they can be useful to robotic applications such as navigation, teleoperation and visual servoing. An effective way to construct this type of vision system is by combining lenses and mirrors together resulting on a system that does not require the movement of the camera to the direction of attention of the robot. A typical construction is by mounting a convex mirror in front of a camera aligning the center of the mirror with the optical axis of the camera. The most common convex mirror shapes used are conic, parabolic, hyperbolic and spherical. In this work we present two types of mirror that were constructed: a spherical mirror, used in the initial tests, and a hyperbolic, used for actual robot tasks. The hyperbolic mirror was manufactured using an ultra-precision CNC machine. Additionally, a software was developed to create panoramic and perspective images from the image acquired by the system. This work shows the development of an omnidirectional vision system, presenting the formulation used to determine a suitable mirror shape, the mechanical solutions used to build a fully operational system, and the results of the developed algorithm.

  12. Proposed tokamak poloidal field system development program

    International Nuclear Information System (INIS)

    A program is proposed to develop poloidal field components for TNS and EPR size tokamak devices and to test these components in realistic circuits. Emphasis is placed upon the development of the most difficult component, the superconducting ohmic-heating coil. Switches must also be developed for testing the coils, and this switching technology is to be extended to meet the requirements for the large scale tokamaks. Test facilities are discussed; power supplies, including a homopolar to drive the coils, are considered; and poloidal field systems studies are proposed

  13. Developing aircraft photonic networks for airplane systems

    DEFF Research Database (Denmark)

    White, Henry J. BAE Systems Ltd.

    2013-01-01

    Achieving affordable high speed fiber optic communication networks for airplane systems has proved to be challenging. In this paper we describe a summary of the EU Framework 7 project DAPHNE (Developing Aircraft Photonic Networks). DAPHNE aimed to exploit photonic technology from terrestrial communications networks, and then develop and optimize aircraft photonic networks to take advantage of the potential cost savings. The main areas of emphasis were on: multiplexing networks; providing standard components; simplifying installation; and reducing through life support costs. DAPHNE (fifteen partners from seven nations) finished in February 2013; and was supported by the European Commission?s Seventh Framework Programme, although the consortium members are continuing with in-house developments.

  14. Developing a Moving Objects Management System

    Directory of Open Access Journals (Sweden)

    Y.E. Ghajary

    2008-01-01

    Full Text Available The aim of this study are to evaluate the current states of the Moving Objects (MO systems and extend them to support tracking, indexing, modeling and visual querying of public transportation buses. To evaluate the system, the queries posed by fleet management companies are selected. The results showed its superior functionalities through text-based and visual queries. This study will contribute to the establishment of a Moving Objects Management System (MOMS with modest expenditure and a short development period and which is independent of the database used.

  15. DEVELOPMENT OF INTELLIGENT SECURITY AND AUTOMATION SYSTEM

    Directory of Open Access Journals (Sweden)

    Diwakar Saxena, Puneet Bisen, Shashank Bhoyerkar

    2012-11-01

    Full Text Available Intelligent security and Automation system is a device that intends to solve the security issues and also provides automation facilities. the two aspects of security and automation are distinguished by a selector switch. the goal is to develop an intelligent security & automation system that gives the user complete security and automation services. this system can work in two modes as indoor mode and outdoor mode. in outdoor mode it provides complete security of the user place and in indoor mode, it provides user help and automation services. in indoor mode, it helps user as energy consumption indicator, light and temperature controller, home appliances controller, automatic door bell indicator

  16. Development of a Sunspot Tracking System

    Science.gov (United States)

    Taylor, Jaime R.

    1998-01-01

    Large solar flares produce a significant amount of energetic particles which pose a hazard for human activity in space. In the hope of understanding flare mechanisms and thus better predicting solar flares, NASA's Marshall Space Flight Center (MSFC) developed an experimental vector magnetograph (EXVM) polarimeter to measure the Sun's magnetic field. The EXVM will be used to perform ground-based solar observations and will provide a proof of concept for the design of a similar instrument for the Japanese Solar-B space mission. The EXVM typically operates for a period of several minutes. During this time there is image motion due to atmospheric fluctuation and telescope wind loading. To optimize the EXVM performance an image motion compensation device (sunspot tracker) is needed. The sunspot tracker consists of two parts, an image motion determination system and an image deflection system. For image motion determination a CCD or CID camera is used to digitize an image, than an algorithm is applied to determine the motion. This motion or error signal is sent to the image deflection system which moves the image back to its original location. Both of these systems are under development. Two algorithms are available for sunspot tracking which require the use of only one row and one column of image data. To implement these algorithms, two identical independent systems are being developed, one system for each axis of motion. Two CID cameras have been purchased; the data from each camera will be used to determine image motion for each direction. The error signal generated by the tracking algorithm will be sent to an image deflection system consisting of an actuator and a mirror constrained to move about one axis. Magnetostrictive actuators were chosen to move the mirror over piezoelectrics due to their larger driving force and larger range of motion. The actuator and mirror mounts are currently under development.

  17. Development of a thermoluminescent personnel monitoring system

    International Nuclear Information System (INIS)

    Thermoluminescent personnel monitoring system has been developed by the Division of Radiological Protection, Bhabha Atomic Research Centre (BARC), Bombay. The system is presently in use for estimation of personnel doses of radiation workers of BARC, other units of the Department of Atomic Energy, and Defence medical units in India. The report gives salient features of the TLD personnel monitoring system. The report discusses design considerations of thermoluminescent dosimetry (TLD) badge for measurement of X and ?;, ? personnel exposures, a filter combination to compensate for energy dependence of the TLD disc and angular dependence of the badge. The badge reader incorporates a semiautomatic mechanical arrangement wherein the TLD cards are read, raising the heater after positioning the TLD discs one by one. Various figures illustrate the mechanical layouts and electronics circuits used in the system. Periodic quality assurance check of the system which ensures a good reproducibility, is also described. (author)

  18. Recent developments in man-machine systems

    International Nuclear Information System (INIS)

    The field of man-machine systems is introduced with its subareas and a short outline of its history of 45 years. Three current lines of development in university and industrial research are emphasized. Today, the human problem solving activities are experimentally investigated and analytically described more vigorously than the control activities. Further, improved information presentations and decision support are made possible through new technologies of computer graphics and expert systems. At last, work on a general design methodology for man-machine systems is in progress. The aim is to better support human operators of dynamic technological systems as well as designers of graphics for visual display units and of dialogue styles. Thereby, safety and availability of the complete system can be increased. (orig.)

  19. Development of PLC-base thermometer system

    International Nuclear Information System (INIS)

    In three power-supply buildings of J-PARC MR, we have used a room-temperature measuring system. However, present system becomes old and unstable. We have designed and installed a new PLC-based system instead. We adopted the same PLC series, Yokogawa F3RP61 and FA-M3R, which have been used in MR accelerator controls. There are 8 sensors at each building, thus, 24 sensors in total. Each sensor is scanned at 1-second interval. In addition, we developed (a) a user-friendly GUI for overviewing temperatures, (b) data archive system with Web-based retrieval, and so on. The new room-temperature measuring system has been in operation very successfully. (author)

  20. Oral health care systems in developing and developed countries

    DEFF Research Database (Denmark)

    Kandelman, Daniel; Arpin, Sophie

    2012-01-01

    Health care systems are essential for promoting, improving and maintaining health of the population. Through an efficient health service, patients can be advised of disease that may be present and so facilitate treatment; risks factors whose modification could reduce the incidence of disease and illness in the future can be identified, and further, how controlling such factors can contribute to maintain a good quality of life. In developed countries, clinics or hospitals may be supported by health professionals from various specialties that allow their cooperation to benefit the patient; these institutions or clinics may be equipped with the latest technical facilities. In developing countries, health services are mostly directed to provide emergency care only or interventions towards certain age group population. The most common diseases are dental caries and periodontal disease and frequently intervention procedures aim, at treating existing problems and restore teeth and related structure to normal function. It is unfortunate that the low priority given to oral health hinders acquisition of data and establishment of effective periodontal care programmes in developing countries but also in some developed countries where the periodontal profile is also less than satisfactory. Despite the fact that in several developed countries there are advanced programmes oriented to periodontal disease treatments, the concern is related to the lack of preventive oriented treatments. According to data available on periodontal status of populations from developed countries, despite the number of dentists and trained specialists, dental health professionals do not presently meet adequately the need for prevention, focusing mainly on curative care. The need for strengthening disease prevention and health promotion programmes in order to improve oral health conditions and particularly periodontal status in the majority of countries around the world is evident. Unfortunately, in many countries, the human, financial and material resources are still insufficient to meet the need for oral health care services and to provide universal access, especially in disadvantaged communities, in both developing and developed countries. Moreover, even though the most widespread illnesses are avoidable, not all population groups are well informed about or able to take advantage of the proper measures for oral health promotion. In addition, in many countries, oral health care needs to be fully integrated into national or community health programmes. Improving oral health is a very challenging objective in developing countries, but also in developed countries, especially with the accelerated aging of the population now underway and intensifying over the coming years.

  1. Development, primacy, and systems of cities.

    Science.gov (United States)

    El-shakhs, S

    1972-10-01

    The relationship between the evolutionary changes in the city size distribution of nationally defined urban systems and the process of socioeconomic development is examined. Attention is directed to the problems of defining and measuring changes in city size distributions, using the results to test empirically the relationship of such changes to the development process. Existing theoretical structures and empirical generalizations which have tried to explain or to describe, respectively, the hierarchical relationships of cities are represented by central place theory and rank size relationships. The problem is not that deviations exist but that an adequate definition is lacking of urban systems on the 1 hand, and a universal measure of city size distribution, which could be applied to any system irrespective of its level of development, on the other. The problem of measuring changes in city size distributions is further compounded by the lack of sufficient reliable information about different systems of cities for the purposes of empirical comparative analysis. Changes in city size distributions have thus far been viewed largely within the framework of classic equilibrium theory. A more differentiated continuum of the development process should replace the bioplar continuum of underdeveloped developed countries in relating changes in city size distribution with development. Implicit in this distinction is the view that processes which influence spatial organization during the early formative stages of development are inherently different from those operating during the more advanced stages. 2 approaches were used to examine the relationship between national levels of development and primacy: a comparative analysis of a large number of countries at a given point in time; and a historical analysis of a limited sample of 2 advanced countries, the US and Great Britain. The 75 countries included in this study cover a wide range of characteristics. The study found a significant association between the degree of primacy of distributions of cities and their socioeconomic level of development; and the form of the primacy curve (or its evolution with development) seemed to follow a consistent pattern in which the peak of primacy obtained during the stages of socioeconomic transition with countries being less primate in either direction from that peak. This pattern is the result of 2 reverse influences of the development process on the spatial structure of countries--centralization and concentration beginning with the rise of cities and a decentralization and spread effect accompanying the increasing influence and importance of the periphery and structural changes in the pattern of authority. PMID:12312642

  2. The Systems Theory Framework of Career Development

    Science.gov (United States)

    McMahon, Mary

    2011-01-01

    The Systems Theory Framework (STF; McMahon & Patton, 1995; Patton & McMahon, 2006) of career development was proposed as a metatheoretical framework that accommodates the contribution of all theories and offers an integrative and coherent framework of career influences. In this article, the author provides an overview of the STF, outlines its…

  3. Recent development on pelletron systems at NEC

    International Nuclear Information System (INIS)

    Some of the most recent developments at NEC are presented. They are: the high current pelletron systems; a variety of small machines for different special purpose; some of the improvements on the accelerating tube and the terminal potential stabilizer; the large horizontal pelletron 8 UDH; the electron cooling technique

  4. Development of the Guardian environmental monitoring system

    International Nuclear Information System (INIS)

    The report describes the Guardian Environmental Monitoring System, developed jointly by the CEGB's Berkeley Nuclear Laboratories (BNL) and GEC Energy Systems Limited (ESL). The basic battery operated instrument was developed by BNL for the measurement of any nuclear facility contribution to the overall environmental dose. It uses an energy compensated Geiger counter to provide a continuous record for over a month of dose rates from 1 ?R h-1 (10nGy h-1). Results are presented of initial development trials and of an intercomparison with the USA Environmental Measurement Laboratory. The Guardian system, however, was developed, not only to meet the CEGB requirements for a recording monitor, but also to meet the requirements of US Regulatory Commission Guide RG 1.97, introduced as a result of the accident at Three Mile Island. This system, by using two energy compensated Geiger counters has a range from 1?Rh-1 up to 10Rh-1 (approximately equal to 100mGyh-1), and the associated electronics provides automatic range changing, including fast response to ramp exposure rate changes, alarm and test facilities and telemetry by line or radio to a central station. (author)

  5. MPACT Fast Neutron Multiplicity System Prototype Development

    Energy Technology Data Exchange (ETDEWEB)

    D.L. Chichester; S.A. Pozzi; J.L. Dolan; M.T. Kinlaw; S.J. Thompson; A.C. Kaplan; M. Flaska; A. Enqvist; J.T. Johnson; S.M. Watson

    2013-09-01

    This document serves as both an FY2103 End-of-Year and End-of-Project report on efforts that resulted in the design of a prototype fast neutron multiplicity counter leveraged upon the findings of previous project efforts. The prototype design includes 32 liquid scintillator detectors with cubic volumes 7.62 cm in dimension configured into 4 stacked rings of 8 detectors. Detector signal collection for the system is handled with a pair of Struck Innovative Systeme 16-channel digitizers controlled by in-house developed software with built-in multiplicity analysis algorithms. Initial testing and familiarization of the currently obtained prototype components is underway, however full prototype construction is required for further optimization. Monte Carlo models of the prototype system were performed to estimate die-away and efficiency values. Analysis of these models resulted in the development of a software package capable of determining the effects of nearest-neighbor rejection methods for elimination of detector cross talk. A parameter study was performed using previously developed analytical methods for the estimation of assay mass variance for use as a figure-of-merit for system performance. A software package was developed to automate these calculations and ensure accuracy. The results of the parameter study show that the prototype fast neutron multiplicity counter design is very nearly optimized under the restraints of the parameter space.

  6. Teaching Information Systems Development via Process Variants

    Science.gov (United States)

    Tan, Wee-Kek; Tan, Chuan-Hoo

    2010-01-01

    Acquiring the knowledge to assemble an integrated Information System (IS) development process that is tailored to the specific needs of a project has become increasingly important. It is therefore necessary for educators to impart to students this crucial skill. However, Situational Method Engineering (SME) is an inherently complex process that…

  7. Developing a solar panel testing system

    Directory of Open Access Journals (Sweden)

    Árpád Rácz

    2009-10-01

    Full Text Available Solar energy is increasingly used togenerate electricity for individual households. There isa wide variety of solar panel technologies, whichshould be tested at an individual level during theirlifetime. In this paper, the development of a testingstation at the University of Debrecen is presented. Thetesting system can be used for research andeducational purposes and for in field applicationsequally well.

  8. Development of DUMAS data processing system

    International Nuclear Information System (INIS)

    In the field of nuclear experiments, the speed-up of data processing has been required recently along with the increase of the amount of data per event or the rate of event occurrence per unit time. In the DUMAS project of RCNP, the development of data processing system has been required, which can perform the high speed transfer and processing. The system should transfer the data of 5 multiwire proportional counters and other counters from the laboratory to the counting room at the rate of 1000 events every second, and also should perform considerably complex processes such as histogramming, particle identification, calculation of various polarizations as well as dumping to the secondary memory in the counting room. Furthermore, easy start-up, adjustment, inspection and maintenance and non-special hardware and software should be considered. A system presently being investigated for satisfying the above requirements is described. The main points are as follows: to employ CAMAC system for the interface with readout circuit, to transfer data between the laboratory and the counting room by converting the byte-serial transfer to the bit-serial optical fiber communication, and to unify the data processing computers to the PDP-11 family by connecting two miniature computers. Development of such a data processing system seems to be useful as an preparatory research for the development of NUMATRON measuring instruments. (Wakatsuki, Y.))

  9. Towards a Provotyping Approach in Systems Development

    DEFF Research Database (Denmark)

    Mogensen, Preben Holst

    1992-01-01

    This paper explores the notion of ‘provocation through concrete experience’ towards a provotyping approach. It addresses the question: How do we on the one hand, devise qualitatively new systems, and on the other hand, ensure their usability in a given practice? The notion of provocation through concrete experience is developed through an investigation of prototyping and activity theory. Exploration of this notion leads to the idea of the systemdeveloper ‘provoking ’ concrete, everyday practice, by exposing current problems, calling forth what usually is taken for granted. Problems with current practice and a lack of mutual understanding, usually conceived of as hindrances to successful systems development, are used constructively. These ideas are compared to four related approaches: Future Workshops, Metaphorical Design, Cooperative Prototyping, and Organizational Games. The comparison serves the twofold purpose of contextualizing the new ideas as well as developing techniques for carrying themout.

  10. Controls system developments for the ERL facility

    Energy Technology Data Exchange (ETDEWEB)

    Jamilkowski, J.; Altinbas, Z.; Gassner, D.; Hoff, L.; Kankiya, P.; Kayran, D.; Miller, T.; Olsen, R.; Sheehy, B.; Xu, W.

    2011-10-07

    The BNL Energy Recovery LINAC (ERL) is a high beam current, superconducting RF electron accelerator that is being commissioned to serve as a research and development prototype for a RHIC facility upgrade for electron-ion collision (eRHIC). Key components of the machine include a laser, photocathode, and 5-cell superconducting RF cavity operating at a frequency of 703 MHz. Starting with a foundation based on existing ADO software running on Linux servers and on the VME/VxWorks platforms developed for RHIC, we are developing a controls system that incorporates a wide range of hardware I/O interfaces that are needed for machine R&D. Details of the system layout, specifications, and user interfaces are provided.

  11. Research and Development Management System (RDMS)

    International Nuclear Information System (INIS)

    Research and Development (R and D) is a main activity carried out at the Malaysian Nuclear Agency particularly in the physical science and nuclear field. The R and D activity that is carried out needs to be managed more efficiently and systematically. Until now all research management activities are carried out manually or semi electronically, beginning from filling in application forms to when the project is completed. Therefore a computerized system is needed in order to manage and monitor R and D projects. The R and D system is capable of giving access information concerning R and D projects which are carried out to users inside and outside the agency. The R and D management system (RDMS) can increase the capability of the Malaysian Nuclear Agency in managing, researching and developing, innovating and inventing technology as well as commercializing the R and D produced. (author)

  12. Development of radiation detection and measurement systems

    International Nuclear Information System (INIS)

    This report contains descriptions on the following six items. The first item is the result of a study on CsI(TI) crystals with their light emitting characteristics and the result of a study on plastic scintillators. The second item is the result of a study on advanced radiation detectors and includes experiments for the effect of using a Compton suppressor with an HPGe detector. For the third item, we describe the results of a design work done using EGS4 for a thickness gauge, a density gauge, and a level gauge. The fourth item contains descriptions on the prototype circuit systems developed for a level gauge, a thickness gauge, and for a survey meter. The fifth part contains the computed tomography algorithm and a prototype scanning system developed for a CT system. As the sixth and the last item, we describe the prototype high precision heat source and the prototype heat-voltage converter which we have designed and fabricated

  13. Development of technical information processing systems

    International Nuclear Information System (INIS)

    The major goal of this project is to develop a more efficient information management system by connecting the KAREI serials database which enable the users to access from their own laboratory facilities through KAREI-NET. The importance of this project is to make the serials information of KAERI easily accessible to users as valuable resources for R and D activities. The results of the project are as follows. 1) Development of the serials database and retrieval system enabled us to access to the serials holding information through KAERI-NET. 2) The database construction establishes a foundation for the management of 1,600 serials held in KAERI. 3) The system can be applied not only to KAERI but also to similar medium-level libraries. (Author)

  14. Advanced CIDI Emission Control System Development

    Energy Technology Data Exchange (ETDEWEB)

    Lambert, Christine

    2006-05-31

    Ford Motor Company, with ExxonMobil and FEV, participated in the Department of Energy's (DOE) Ultra-Clean Transportation Fuels Program with the goal to develop an innovative emission control system for light-duty diesel vehicles. The focus on diesel engine emissions was a direct result of the improved volumetric fuel economy (up to 50%) and lower CO2 emissions (up to 25%) over comparable gasoline engines shown in Europe. Selective Catalytic Reduction (SCR) with aqueous urea as the NOx reductant and a Catalyzed Diesel Particulate Filter (CDPF) were chosen as the primary emission control system components. The program expected to demonstrate more than 90% durable reduction in particulate matter (PM) and NOx emissions on a light-duty truck application, based on the FTP-75 drive cycle. Very low sulfur diesel fuel (<15 ppm-wt) enabled lower PM emissions, reduced fuel economy penalty due to the emission control system and improved long-term system durability. Significant progress was made toward a durable system to meet Tier 2 Bin 5 emission standards on a 6000 lbs light-duty truck. A 40% reduction in engine-out NOx emissions was achieved with a mid-size prototype diesel engine through engine recalibration and increased exhaust gas recirculation. Use of a rapid warm-up strategy and urea SCR provided over 90% further NOx reduction while the CDPF reduced tailpipe PM to gasoline vehicle levels. Development work was conducted to separately improve urea SCR and CDPF system durability, as well as improved oxidation catalyst function. Exhaust gas NOx and ammonia sensors were also developed further. While the final emission control system did not meet Tier 2 Bin 5 NOx after 120k mi of aging on the dynamometer, it did meet the standards for HC, NMOG, and PM, and an improved SCR catalyst was shown to have potential to meet the NOx standard, assuming the DOC durability could be improved further. Models of DOC and SCR function were developed to guide the study of several key design factors for SCR systems and aid in the development of urea control strategy for maximum NOx reduction with minimum NH3 slip. A durable co-fueling system was successfully built and tested, with the help of service station nozzle and dispenser manufacturers, for simultaneous delivery of diesel fuel and aqueous urea to the vehicle. The business case for an aqueous urea infrastructure in the US for light-duty vehicles was explored.

  15. Statement about researches relative to the operation stability of the MPS P230 of Ariane 5; Point sur les recherches relatives a la stabilite de fonctionnement du MPS P230 d'Ariane 5

    Energy Technology Data Exchange (ETDEWEB)

    Vuillot, F.

    1998-07-01

    This paper makes a statement about the researches carried out in the framework of the ASSM (Aerodynamics of Segmented Solid Motors) research program on the operation stability of the MPS P230 solid propellant engine of the French Ariane 5 launcher. After a brief historical recall of the works performed on this topic during the last 10 years, the present day situation is detailed. The feasibility of a numerical capture of the instability phenomenon is now achieved and 3 scenarios leading to swirl flow instabilities could be identified. These scenarios were validated using numerical simulation, simulation in cold gases, and launcher tests. However, one scenario based on a strong instability mechanism, seems to better fit with the observations made on the P230 engine and will deeply influence the scientific strategy of the research program. (J.S.)

  16. Development of Intellectual Reactor Design System: IRDS

    International Nuclear Information System (INIS)

    In the frame of the new theme 'Study of analysis method of new nuclear power systems' admitted in our Reactor system laboratory since FY 1988, a program to develop the Intellectual Reactor Design System (IRDS) in the same spirit as ADES has been established. This report describes the activities related to IRDS performed in FY 1989. One of major activities is drafting IRDS. It reflects the conclusion of the STA ADES committee. The essence is to construct a modular system under the object-oriented programming environment to provide a conversational tool for feasibility study and conceptual design. Along the draft the following items were executed in the FY. For the realization of the conversational tool, a tool for input data generation by an object-oriented programming and another tool like CAD for geometry input data generation by a conversational processing of figures on display were examined. Upon the study how to construct the object-oriented data base, the class and frame structures of the design data base were drafted. As components of the modular system, programming of a neutronics and a thermohydraulics module for feasibility study was started. Also a structure analysis code was studied for conversion. In the coming FY, the computer system which has been composed by a FACOM host machine and terminals or isolated PCs will be exchanged by a SUN work-station linked with the host machine and PCs by an ETHER network. Under the suitable environment, the development of IRDS will be promoted. (author)

  17. Development of compact CCTV surveillance system. 'COSMOS'

    International Nuclear Information System (INIS)

    The Compact Surveillance and Monitoring System, 'COSMOS' has been developed as a compact, simple, highly reliable CCTV surveillance system. The system is intended to provide a direct replacement for the IAEA Twin Minolta film camera systems. The system consists of a recording unit and a set up/review unit. The recording unit, consisting of a CCD camera module, a 8mm VTR unit, a controller module and a power unit, is contained in a tamper indicating housing. The VTR module of very low power consumption is specially developed for COSMOS capable of battery operation. The system can be operated for three months either by battery without battery change where mains power is not readily available or by AC powers. The field-use model of COSMOS was completed in 1991. The field-evaluation test by the IAEA and JAERI was successfully completed in 1993. The IAEA accepted the COSMOS as a routine-use device in August 1993. This report describes the performance features and IAEA test result of COSMOS. (author)

  18. Development of Korea Operational Oceanographic System (KOOS)

    Science.gov (United States)

    Park, Kwang Soon; Jun, Ki Cheon; Lee, Jong Chan; Kwon, Jae Il; Cho, Kyung Ho; Choi, Jung Woon; Kim, Sung Dae; Kim, Jin Ah; Kim, Sang Ik; Kim, Yong Ho; Choi, Byung Ju

    2013-04-01

    Korea Operational Oceanographic System (KOOS) is a research project funded by the Minister of Land, Transport and Maritime Affairs (MLTM) in Korea and the goal of this project is to develop an integrated operational oceanographic system that will provide nowcasts and forecasts of ocean information around Korean Peninsula to support marine activities for governmental agencies and to mitigate coastal disasters such as storm surge, oil spill, and search and rescue. Since August 2009, KIOST has been leading the project to develop KOOS, which consists of three parts, 1) observing systems, 2) numerical modeling with data management and skill assessment, and 3) practical application systems. In KOOS about 190 real-time coastal/ocean observing platforms such as tidal stations, buoys, off-shore research stations and satellites from various agencies, KIOST, KHOA (Korea Hydrographic and Oceanographic Administration), NFRDI (National Fisheries Research & Development Institute), and KMA (Korea Meteorological Administration) have been used for input data as well as calibration and validation for numerical models. With observing networks, various atmospheric models and ocean models have been set-up and tested. KOOS enables us to forecast tides, waves, storm surges, currents as well as temperature and salinity for 72-hour time period in two time a day. The performance of numerical models is evaluated by the skill assessment system. For practical purposes, KOOS has various application systems such as storm surge, search and rescues, oil spill, and ports and channel prediction system. All ocean information in KOOS is to be presented via web-based GIS, which is an effective tool that is helpful to decision-makers.

  19. Development of a digital mammography system

    International Nuclear Information System (INIS)

    A digital breast imaging system is under development to provide improved detectability of breast cancer. In previous work, the limitations of screen-film mammography were studied using both theoretical and experimental techniques. Important limitations were found in both the acquisition and the display components of imaging. These have been addressed in the design of a scanned-projection digital mammography system. A high resolution x-ray image intensifier (XRII), optically coupled to a self-scanned linear photodiode array, is used to record the image. Pre- and post-patient collimation virtually eliminates scattered radiation and veiling glare of the XRII with only a 20% increase in dose due to penumbra. Geometric magnification of 1.6 times is employed to achieve limiting spatial resolution of 7 lp/mm. For low-contrast objects as small as 0.1 mm in diameter, the digital system is capable of producing images with higher contrast and signal-to-noise ratio than optimally-exposed conventional film-screen mammography systems. Greater latitude is obtainable on the digital system because of its wide dynamic range and linearity. The slit system is limited due to long image acquisition times, and poor quantum efficiency. This motivated the authors' current work on a slot beam digital mammography system which is based on a fiber-optic x-ray detector. Preliminary results of this system are presented

  20. MIT: Global System for Sustainable Development

    Science.gov (United States)

    Global System for Sustainable Development (GSSD) is a project of the Global Accords Consortium for Sustainable Development that is "dedicated to internationalization of knowledge access, provision & sharing for 'reducing the gap between knowledge & policy.'" Housed at the Massachusetts Institute of Technology (MIT), GSSD is "a multi-dimensional knowledge networking system" that combines public and private networks to provide a continually evolving cross-referenced knowledge base for informing decision-making and policy in the domain of "sustainable development." The Using GSSD section of the website provides information on the organizing principles used to develop the database, demonstrates the functionality and architecture of the system and other aspects of the project, such as the multiple mirror sites that are in languages other than English. Reports and working papers from the GSSD are also posted. Visitors can search the holdings of the database using a text search or based on other parameters, such as issue area or industry type, and are invited to submit websites to be considered for inclusion.

  1. Developing 360 degree feedback system for KINS

    Energy Technology Data Exchange (ETDEWEB)

    Han, In Soo; Cheon, B. M.; Kim, T. H.; Ryu, J. H. [Chungman National Univ., Daejeon (Korea, Republic of)

    2003-12-15

    This project aims to investigate the feasibility of a 360 degree feedback systems for KINS and to design guiding rules and structures in implementing that systems. Literature survey, environmental analysis and questionnaire survey were made to ensure that 360 degree feedback is the right tool to improve performance in KINS. That review leads to conclusion that more readiness and careful feasibility review are needed before implementation of 360 degree feedback in KINS. Further the project suggests some guiding rules that can be helpful for successful implementation of that system in KINS. Those include : start with development, experiment with one department, tie it to a clear organization's goal, train everyone involve, make sure to try that system in an atmosphere of trust.

  2. MPC system development a utility industry assessment

    International Nuclear Information System (INIS)

    The Department of Energy is currently pursuing development of a Multi Purpose Container System (MPCS) which would serve as a standardized packaging approach for bringing the nation's spent nuclear fuel from the utility sites into the federal spent fuel management system. Specifically, this system will enhance integration of the transportation, interim storage, and disposal components of the waste program. Such integration and standardization should result in economic and operations benefits to the Waste Disposal System. Consequently, the Nuclear Industry is very supportive of the effort. This project will clearly create extensive interface challenges which must be overcome. An ongoing cooperative effort between the utilities, the DOE, and associated contractors will be necessary to ensure an optimum design and successful deployment

  3. Development of the real time monitor system

    International Nuclear Information System (INIS)

    Large-scale simulation technique is studied at the Center for Promotion of Computational Science and Engineering (CCSE) for the computational science research in nuclear fields. Visualization and animation processing technique are studied and developed for efficient understanding of simulation results. The real time monitor system, in which on-going simulation results are transferred from a supercomputer or workstation to a graphic workstation and are visualized and recorded, is described in this report. This system is composed of the graphic workstation and the video equipment connected to the network. The control shell programs are the job-execution shell for simulations on supercomputers, the file-transfer shell for output files for visualization, and the shell for starting visualization tools. Special image processing technique and hardware are not necessary in this system and the standard visualization tool AVS and the UNIX commands are used, so that this system can be implemented and applied in various computer environments. (author)

  4. PLM system support for modular product development

    DEFF Research Database (Denmark)

    Bruun, Hans Peter Lomholt; Mortensen, Niels Henrik

    2015-01-01

    A modular design strategy both enables, but also demands, parallelism in design activities and collaboration between a diversity of disciplines in companies, which often involves supporting computer-based tools for enhancing interaction, design management, and communication. Product data management (PDM) and product lifecycle management (PLM) systems offer support by automating and managing some of the operational complexity of modular design activities. PLM system tools are used for handling a variety of product definitions, to manage workflow of development activities, and to measure relational properties such as cost and performance. Companies often use a PLM tool for management of CAD files, documents, and drawings, but they do not take advantage of the full potential of the PLM system to support the development activities of modular product designs. The key result of this paper is the description of an empirical tested approach using a visual product architecture representation in combination with a PLM system to support the development of a product family of products. The results from the study encompass new PLM capabilities for handling multiple product structures, visualising multiple architectural views on products, controlling interfaces, and quantifying and communicating the status and progress of product-related resources. © 2014 Elsevier B.V. All rights reserved.

  5. Information system development activities and inquiring systems : an integrating framework

    DEFF Research Database (Denmark)

    Carugati, Andrea

    2008-01-01

    This article presents a framework that maps information system development (ISD) activities on systems for the creation of knowledge. This work addresses the relevant and persisting problem of improving the chances of ISD success. The article builds upon previous research on knowledge aspects of ISD, abandoning the idea of a monolithic approach to knowledge and presenting a pluralistic approach based on the idea that different inquiring systems can support micro-level ISD activities. The article is divided into two parts. The first part presents the theoretical development of the framework based on ISD literature and on Churchman's (1971) inquiring systems. The second part presents the use of the framework in an ISD project. The case is used to show the applicability of the framework and to highlight the advantages of this approach. The main theoretical implication is that the framework provides a new way to see the development of a system in terms of the knowledge created in the process. The main practical implication of the framework is that it improves the managers' ability to guide ISD activities as knowledge activities embedded in a knowledge process, a crucial element in development projects. Udgivelsesdato: APR

  6. Sensor Development for PEM Fuel Cell Systems

    Energy Technology Data Exchange (ETDEWEB)

    Steve Magee; Richard Gehman

    2005-07-12

    This document reports on the work done by Honeywell Sensing and Control to investigate the feasibility of modifying low cost Commercial Sensors for use inside a PEM Fuel Cell environment. Both stationary and automotive systems were considered. The target environment is hotter (100 C) than the typical commercial sensor maximum of 70 C. It is also far more humid (100% RH condensing) than the more typical 95% RH non-condensing at 40 C (4% RH maximum at 100 C). The work focused on four types of sensors, Temperature, Pressure, Air Flow and Relative Humidity. Initial design goals were established using a market research technique called Market Driven Product Definition (MDPD). A series of interviews were conducted with various users and system designers in their facilities. The interviewing team was trained in data taking and analysis per the MDPD process. The final result was a prioritized and weighted list of both requirements and desires for each sensor. Work proceeded on concept development for the 4 types of sensors. At the same time, users were developing the actual fuel cell systems and gaining knowledge and experience in the use of sensors and controls systems. This resulted in changes to requirements and desires that were not anticipated during the MDPD process. The concepts developed met all the predicted requirements. At the completion of concept development for the Pressure Sensor, it was determined that the Fuel Cell developers were happy with off-the-shelf automotive pressure sensors. Thus, there was no incentive to bring a new Fuel Cell Specific Pressure Sensor into production. Work was therefore suspended. After the experience with the Pressure Sensor, the requirements for a Temperature Sensor were reviewed and a similar situation applied. Commercially available temperature sensors were adequate and cost effective and so the program was not continued from the Concept into the Design Phase.

  7. Development of the Medium Energy Linac Systems

    International Nuclear Information System (INIS)

    The main purpose of this project is developing 100-MeV proton linear accelerator (linac) for proton engineering frontier project (PEFP). In the first phase of the PEFP, the development of the 20-MeV linac has successfully finished. Hence the work scope of this project is designing the linac to accelerate proton beams from 20-MeV up to 100-MeV, fabricating the linac up to 45 MeV, fabricating one set of the medium energy beam transport (MEBT) tank, and developing the low level radio frequency (LLRF) system and the control system. The basic role of the new proton accelerator is accelerating 20-mA proton beams from 20 MeV up to 100 MeV. The first step of the design procedure is optimizing and determining the accelerator parameters. The beam loss is also main concern in the design stage. The drift tube (DT) and the quadrupole magnets are designed to be optimized to the new linac design. The other purpose is confirming the new design by fabricating and tuning the drift tube linac (DTL). The 20MeV proton beam divided into two directions. One is supplying the beams to user group by turning on the 45-degree bending magnet. The other is guided into the 100-MeV DTL by tuning off the dipole magnet. That is why the PEFP MEBT located after 20-MeV DTL. The MEBT is realized as two small DTL tanks with three cells and a 45-degree bending magnet. The fabrication of one MEBT tank is another purpose of this project. The other purposes of this project is developing the LLRF system to control the RF signal and control system to monitor and control the vacuum system, magnet power supply, etc

  8. Advanced Turbine Systems Program industrial system concept development

    Energy Technology Data Exchange (ETDEWEB)

    Gates, S. [Solar Turbines Inc., San Diego, CA (United States)

    1995-10-01

    The objective of Phase II of the Advanced Turbine Systems Program is to develop conceptual designs of gas fired advanced turbine systems that can be adapted for operation on coal and biomass fuels. The technical, economic, and environmental performance operating on natural gas and in a coal fueled mode is to be assessed. Detailed designs and test work relating to critical components are to be completed and a market study is to be conducted.

  9. Development of design window evaluation and display system. 1. System development and performance confirmation

    International Nuclear Information System (INIS)

    Purpose: The work was performed to develop a design window evaluation and display system for the purpose of obtaining the effects of various design parameters on the typical thermal hydraulic issues resulting from a use of various kind of working fluid etc. easily. Method: The function of the system were 'confirmation of design margin' of the present design, 'confirmation of the affected design zone' when a designer changed some design parameter, and search for an design improvement' for design optimization. The system was developed using existing soft wares on PC and the database relating analytical results of typical thermal hydraulic issues provided by separate work. Results: (1) System design: In order to develop a design window evaluation and display system, 'numerical analysis unit', 'statistical analysis unit', 'MMI unit', 'optimization unit' were designed based on the result of selected optimization procedure and display visualization. Further, total system design was performed combining these units. Typical thermal hydraulic issues to be considered are upper plenum thermal hydraulics, thermal stratification, free surface sloshing, flow-induced vibration of a heat exchanger and thermal striping in the T-junction piping systems. (2) Development of prototype system and a functional check: A prototype system of a design window evaluation and display system was developed and the functions were confirmed as was planned. (author)thor)

  10. Development of evaluation system for flashing erosion

    International Nuclear Information System (INIS)

    Liquid droplet impingement erosion (LDI) is defined as an erosion phenomenon caused by high-speed droplet attack in a wet steam flow, and sometimes observed in a steam piping system of a power plant. In our previous researches, we have developed an LDI evaluation system to evaluate the thinning shape due to LDI on a steam piping within a practically acceptable time. However, present system is not applicable to LDI on a hot-water piping due to flashing phenomena (flashing erosion) because it is difficult to calculate the flashing flow due to sudden phase change and critical flow rate evaluation models needed for LDI evaluation system are not verified in wet steam region. Therefore, in this study, we tried to develop a new flow calculation code for flashing flow and to verify the critical flow rate evaluation models in wet steam region. For flashing flow simulation, based on a present CFD code, pre-conditioning method was adopted to achieve the stable calculation of the water region, and extended look-up table including from low-pressure water to high-pressure dry steam was incorporated. Finally, a new CFD code water-steam flow was developed. Several benchmark tests were conducted and those results show this new code can reproduce the flashing phenomena and is applicable from the very low-speed flow to supersonic flow. Then, HEM model for critical mass flow rate was verified with flashing and wet steam experiments and CFD calculations, and incorporated into LDI evaluation system to extend applicable region of the evaluation system into flashing erosion. (author)

  11. Equipment system for advanced nuclear fuel development

    International Nuclear Information System (INIS)

    The purpose of the settlement of equipment system for nuclear Fuel Technology Development Facility(FTDF) is to build a seismic designed facility that can accommodate handling of nuclear materials including <20% enriched Uranium and produce HANARO fuel commercially, and also to establish the advanced common research equipment essential for the research on advanced fuel development. For this purpose, this research works were performed for the settlement of radiation protection system and facility special equipment for the FTDF, and the advanced common research equipment for the fuel fabrication and research. As a result, 11 kinds of radiation protection systems such as criticality detection and alarm system, 5 kinds of facility special equipment such as environmental pollution protection system and 5 kinds of common research equipment such as electron-beam welding machine were established. By the settlement of exclusive domestic facility for the research of advanced fuel, the fabrication and supply of HANARO fuel is possible and also can export KAERI-invented centrifugal dispersion fuel materials and its technology to the nations having research reactors in operation. For the future, the utilization of the facility will be expanded to universities, industries and other research institutes

  12. Regenerative braking system development, phase 1

    Energy Technology Data Exchange (ETDEWEB)

    Garland, L.A.; Baertschi, E.

    1993-01-01

    A proof-of-concept regenerative braking system for a transit bus was developed. The system uses a hydraulic pump to pump fluid against a gas accumulator during vehicle braking. The energy thus stored is then used to accelerate the vehicle, as required, by the hydraulic pump acting as a motor. When the stored energy has been used, the vehicle engine resumes normal operation. The goal of the project was to develop the proof-of-concept vehicle into a commercially viable design, to build and install a prototype system onto a proof-of-concept vehicle, and to carry out performance tests to assess the system's effectiveness. The test results showed that most targets could be met, in particular the operation of the bus to its standard maximum speed, and the increase of absolute fuel savings in the low speed driving cycle of 11.5 liters/100 km. Some targets could not actually be implemented but were addressed in detailed designs and studies, such as the implementation of a drive interface with integrated clutch to completely disengage the regenerative braking system from the vehicle drive train, application of light weight accumulators, and elimination of the main hydraulic manifold. Targeted weight reduction of the actual installation could not be achieved, but are expected to be possible in future design enhancements. 7 refs., 9 figs., 9 tabs.

  13. Development of a fast closing valve system

    International Nuclear Information System (INIS)

    A fast closing valve is usually connected to a beam line branched from an electron storage ring. It protects the ultra-high-vacuum (UHV) system against inrushes of air, which may accidentally occur at a measuring station located at the down stream of the beam flow. The simplest system of a fast closing valve consists of a vacuum pressure sensor, a fast closing valve (FCV) and a system controller. These components of a FCV system are based on some fundamental technologies, for instance, extremely quick responsive measurements of vacuum pressure changes, rapid conversions of input singnals into outputs, transmissions of the signals in noisy circumstances, quick actions of the mechanism, characteristics of low leak rate, reliability and long life of the system. Some of these are common and useful technologies for fusion devices, also. The authors have developed two types of fast closing valve systems. The closing time guaranteed is 50 ms and 10 ms respectively for the nearly same aperture size of 150 x 15 mm. In this paper, the 10 ms FCV system is mainly described. Materials of the valve are non magnetic, and have low outgassing rates and low damage rates for synchrotron radiation (SR). The baking temperature is allowed to be 2000C. The leak rate characteristics are kept within about 0.1 Torr.lit/sec. (1.33 x 10-2 Pa m3/sec.), even after closing operations of 1000 times

  14. MR imaging of central nervous system development

    International Nuclear Information System (INIS)

    This paper reports on the first in vitro MR imaging study of human developmental anatomy. Formalin-preserved embryos and fetuses of gestational ages ranging from 8 to 38 weeks were studied with MR imaging to determine normal anatomy, with emphasis on the central nervous system. In vivo MR imaging of neonates and infants up to 18 months of age was also obtained to demonstrate the normal pattern of maturation and myelination of the brain. The normal development of the brain is shown, with some additional highlights of the spinal cord, gastrointestinal and genitourinary tracts, cardiovascular structures, and respiratory system

  15. Development of advanced fuel cell system

    Science.gov (United States)

    Grevstad, P. E.

    1972-01-01

    Weight, life and performance characteristics optimization of hydrogen-oxygen fuel cell power systems were considered. A promising gold alloy cathode catalyst was identified and tested in a cell for 5,000 hours. The compatibility characteristics of candidate polymer structural materials were measured after exposure to electrolyte and water vapor for 8,000 hours. Lightweight cell designs were prepared and fabrication techniques to produce them were developed. Testing demonstrated that predicted performance was achieved. Lightweight components for passive product water removal and evaporative cooling of cells were demonstrated. Systems studies identified fuel cell powerplant concepts for meeting the requirements of advanced spacecraft.

  16. Reframing Humans in Information Systems Development

    CERN Document Server

    Isomaki, Hannakaisa

    2011-01-01

    Modern society has been transformed by the digital convergence towards a future where technologies embed themselves into the fabric of everyday life. This ongoing merging of social and technological infrastructures provides and necessitates new possibilities to renovate past notions, models and methods of information systems development that accommodates humans as actors within the infrastructure. This shift introduces new possibilities for information systems designers to fulfil more and more everyday functions, and to enhance their value and worth to the user. "Reframing Humans in Infor

  17. Risk management in information system development

    OpenAIRE

    Ristola, Teemu

    2011-01-01

    The purpose of this study is to facilitate the implementation process of the case corporation’s new information system for managing their inventory of bus tires. This study attempts to answer the questions “What were the main IT-risks in-volved with the development and implementation of the new bus tire inventory management system, what kind of effects did they have and how were they dealt with”. The study was carried out with the cooperation of the case corporation, Koiviston Auto, as ...

  18. Space Launch System Accelerated Booster Development Cycle

    Science.gov (United States)

    Arockiam, Nicole; Whittecar, William; Edwards, Stephen

    2012-01-01

    With the retirement of the Space Shuttle, NASA is seeking to reinvigorate the national space program and recapture the public s interest in human space exploration by developing missions to the Moon, near-earth asteroids, Lagrange points, Mars, and beyond. The would-be successor to the Space Shuttle, NASA s Constellation Program, planned to take humans back to the Moon by 2020, but due to budgetary constraints was cancelled in 2010 in search of a more "affordable, sustainable, and realistic" concept2. Following a number of studies, the much anticipated Space Launch System (SLS) was unveiled in September of 2011. The SLS core architecture consists of a cryogenic first stage with five Space Shuttle Main Engines (SSMEs), and a cryogenic second stage using a new J-2X engine3. The baseline configuration employs two 5-segment solid rocket boosters to achieve a 70 metric ton payload capability, but a new, more capable booster system will be required to attain the goal of 130 metric tons to orbit. To this end, NASA s Marshall Space Flight Center recently released a NASA Research Announcement (NRA) entitled "Space Launch System (SLS) Advanced Booster Engineering Demonstration and/or Risk Reduction." The increased emphasis on affordability is evident in the language used in the NRA, which is focused on risk reduction "leading to an affordable Advanced Booster that meets the evolved capabilities of SLS" and "enabling competition" to "enhance SLS affordability. The purpose of the work presented in this paper is to perform an independent assessment of the elements that make up an affordable and realistic path forward for the SLS booster system, utilizing advanced design methods and technology evaluation techniques. The goal is to identify elements that will enable a more sustainable development program by exploring the trade space of heavy lift booster systems and focusing on affordability, operability, and reliability at the system and subsystem levels5. For this study, affordability is defined as lifecycle cost, which includes design, development, test, and engineering (DDT&E), production and operational costs (P&O). For this study, the system objectives include reducing DDT&E schedule by a factor of three, showing 99.9% reliability, flying up to four times per year, serving both crew and cargo missions, and evolving to a lift capability of 130 metric tons.3 After identifying gaps in the current system s capabilities, this study seeks to identify non-traditional and innovative technologies and processes that may improve performance in these areas and assess their impacts on booster system development. The DDT&E phase may be improved by incorporating incremental development testing and integrated demonstrations to mitigate risk. To further reduce DDT&E, this study will also consider how aspects of the booster system may have commonality with other users, such as the Department of Defense, commercial applications, or international partners; by sharing some of the risk and investment, the overall development cost may be reduced. Consideration is not limited to solid and liquid rocket boosters. A set of functional performance characteristics, such as engine thrust, specific impulse (Isp), mixture ratio, and throttle range are identified and their impacts on the system are evaluated. This study also identifies how such characteristics affect overall life cycle cost, including DDT&E and fixed and variable P&O.

  19. Development of technical information processing system (VII)

    International Nuclear Information System (INIS)

    The goal of this project is to establish integrated environment focused on enhanced information services to researchers through the providing of acquisition information, key phrase retrieval function, journal content information linked with various subsystems already developed. The results of the project are as follows. 1. It is possible to serve information on unreceivable materials among required materials throughout the system. 2. Retrieval efficiency is increased by the adding of key phrase retrieval function. 3. Rapidity of information service is enhanced by the providing of journal contents of each issue received and work performance of contents service is become higher. 4. It is possible to acquire, store, serve technical information needed in R and D synthetically and systematically throughout the development of total system linked with various subsystems required to technical information management and service. 21 refs. (Author)

  20. A Guerilla Approach to Control System Development

    CERN Document Server

    Dovc, J; Plesko, M

    2001-01-01

    We present our experiences in managing the development cycles of the control systems for ANKA and the ALMA Common Software. Our team consists practically only of undergraduate students. Stimulating and rewarding the students with cutting-edge technologies and travel to conferences like this and installation fieldwork are an important positive factor in raising their motivation. However, building any system with a group of inexperienced students is quite a challenging task. Many problems occur with planning deadlines and missing them, organizing and managing development, sources, and documentation and also when dealing with conventional program management rules. To cope with them, we use many tools: CVS for versioning and source archiving, Bugzilla for keeping our bugs in order, a to-do list for managing tasks, an activity log and also many other programs and scripts, some found on the Internet and some made by ourselves. In the end, we had to become organized like a professional company. Documentation and dem...

  1. Stirling Convertor System Dynamic Model Developed

    Science.gov (United States)

    Lewandowski, Edward J.; Regan, Timothy F.

    2005-01-01

    Free-piston Stirling convertors are being developed for potential use on NASA exploration missions. In support of this effort, the NASA Glenn Research Center has developed the Stirling convertor System Dynamic Model (SDM). The SDM models the Stirling cycle thermodynamics; heat flow; gas, mechanical, and mounting dynamics; the linear alternator; and the controller. The SDM s scope extends from the thermal energy input to thermal, mechanical, and electrical energy output, allowing one to study complex system interactions among subsystems. Thermal, mechanical, fluid, magnetic, and electrical subsystems can be studied in one model. The SDM is a nonlinear time-domain model containing sub-cycle dynamics, which simulates transient and dynamic phenomena that other models cannot. The entire range of convertor operation is modeled, from startup to full-power conditions.

  2. Remote maintenance system development for ITER blankets

    International Nuclear Information System (INIS)

    In ITER, the in-vessel components such as blanket are to be maintained or replaced remotely since they will be activated by 14 MeV neutrons. For this, the remote handling equipment for blanket maintenance is required to handle a heavy payload of about 4 tonne within a positioning accuracy of 2 mm. According to the ITER R and D program, a rail-mounted vehicle manipulator system was developed and remote replacement of blanket module has been successfully demonstrated using the fabricated full-scale vehicle manipulator system. In addition, the bore tools moving inside the blanket cooling pipes were also developed, and remote welding, cutting and inspection operations for the blanket maintenance have been verified. (author)

  3. Laser-produced plasma source system development

    Science.gov (United States)

    Brandt, David C.; Fomenkov, Igor V.; Ershov, Alex I.; Partlo, William N.; Myers, David W.; Böwering, Norbert R.; Vaschenko, Georgiy O.; Khodykin, Oleh V.; Bykanov, Alexander N.; Hoffman, Jerzy R.; Chrobak, Christopher P.; Srivastava, Shailendra N.; Vidusek, David A.; De Dea, Silvia; Hou, Richard R.

    2008-11-01

    This paper provides a review of development progress for a laser-produced-plasma (LPP) extreme-ultra-violet (EUV) source with performance goals targeted to meet joint requirements from all leading scanner manufacturers. Laser produced plasma systems have been developed as a viable approach for the EUV scanner light source for optical imaging of circuit features at sub-32nm and beyond nodes on the ITRS roadmap. Recent advances in the development of the system, its present average output power level and progress with various subcomponents is discussed. We present the latest results on peak EUV and average EUV power as well as stability of EUV output, measured in burst-mode operation at the nominal repetition rate of the light source. In addition, our progress in developing of critical components, such as normal-incidence EUV collector and liquid-target delivery system is described. We also report on dose stability, plasma position stability and EUV distribution at the output region of the source. This presentation reviews the experimental results obtained on systems with a focus on the topics most critical for an HVM source. The capability to scale LPP power by further development of the high power CO2 drive laser in order to increase duty cycle and duration of continuous light source operation is shown. Production systems with thermal management and capable of 5 sr light collection are being assembled and tested. A description of the development of a normal-incidence ellipsoidal collector is included. Improvements in substrate quality lead to increased EUV reflectance of the mirror. Results on the generation of liquid tin droplets as target material for efficient plasma generation are also described. The droplet generator serves as a key element in the precise and spatially stable delivery of small quantities of liquid tin at high repetition rates. We describe a protection module at the intermediate focus (IF) region of the source and imaging of the EUV distribution using a sub-aperture collector and a fluorescent screen. A path to meet requirements for production scanners planned well into the next decade is also presented.

  4. Development of NMCA system and software

    International Nuclear Information System (INIS)

    Full text: Development of the NMCA system in the Institute of Atomic Energy is described. The Institute is the one of research scientific subdivisions of the National Nuclear Center of the Republic of Kazakhstan. Four nuclear facilities in the country is operating. Institute is a facility with two research reactors, located on the remote sites of the former Semipalatinsk nuclear test site. Layouts and main parameters of the reactors are attached. In additional to reactors, NM storages, on-pile stands, research labs and hot cell are located on sites. The NM storing and handling are covered by NMCA system which after USSR disintegration was in a bad condition: on-paper account, lack of personal training, normative documents, measuring system, and access control. After ratification of Safeguards Agreement all Kazakhstan's nuclear facilities became to being inspected by IAEA and State authority. Putting of the NMCA system according to international rules is started. Since 1993 a collaboration with Departments of Defense and Energy is begun, particularly with Los-Alamos, Sandia and Oak-Ridge National labs. Directions of development and needs of technical and methodical assistance were defined. In the following time a computers for account, spectrometric and weighing equipment for NDA, TID and other office equipment were delivered. Development of a number of documents concerning regulation of NM handling, IAEA inspectors cooperation, reporting was conducted under ORNL support. NMCA custodians were participants of many training courses held in Kazakhstan, NIS, LANL, NRC. The computerized NMCA system 'AIMAS' developed in ANL and delivered to the Institute was implemented successfully in 1995. During some followed years the 'AIMAS' system was modified step by step and spread to other nuclear facilities of Kazakhstan and Uzbekistan under DOE support. The important element of supporting of SSAC development in Kazakhstan is funding and providing with methodic of annual workshops-conferences for NMCA custodians from Kazakhstan and Uzbekistan. These meetings are conducted continuously on the all nuclear facilities so that the NMCA specialists have a chance to meet their progress in NMCA area. Last such meeting was conducted in August 2005 at the Institute of Atomic Energy. (author)

  5. Development of the banking system in Georgia

    OpenAIRE

    Kbiltsetskhlashvili, Tea

    2008-01-01

    Over fifteen years have passed since the beginning of the reconstruction of the transition countries' banking systems. The analysis of the development of commercial banking in Georgia and other transition countries points out several features, which are typical for the starting period of financial sector reforms. It turns out from this article that the success of the reconstruction of banking sector in certain countries differs substantially. Since the starting of reforms the Georgian banking...

  6. Low cost attitude control system scanwheel development

    Science.gov (United States)

    Bialke, William; Selby, Vaughn

    1991-01-01

    In order to satisfy a growing demand for low cost attitude control systems for small spacecraft, development of low cost scanning horizon sensor coupled to a low cost/low power consumption Reaction Wheel Assembly was initiated. This report addresses the details of the versatile design resulting from this effort. Tradeoff analyses for each of the major components are included, as well as test data from an engineering prototype of the hardware.

  7. Developing innovative systems for reinforced masonry walls

    OpenAIRE

    Mosele, F.; Porto, F. Da; Modena, C.; Fusco, A. Di; Cesare, G. Di; Vasconcelos, Grac?a; Haach, V.; Lourenc?o, Paulo B.; Beer, I.; Schmidt, U.; Brameshuber, W.; Scheufler, W.; Schermer, D. C.; Zilch, K.

    2006-01-01

    The Commission of the European Communities has recently funded a CRAFT research project aimed at developing innovative systems for load and non-load-bearing reinforced masonry walls. The project involves twelve partners coming from four different European countries, among which there are universities and research centres, small and medium enterprises for the production of clay and concrete units and mortars, a company for advanced metal products and industrial associations of brick and block ...

  8. Development of a laundry radwaste treatment system

    International Nuclear Information System (INIS)

    Fundamental bench tests have been performed to develop a radioactive laundry radwaste treatment system, involving ozone/activated carbon, reverse osmosis membrane, and ion exchanger. A pre-treatment technique was employed for the removal of detergent, using a ozonization (ozone/H2O2). Adsorption of detergent and radionuclides by various commercial adsorbents and removal of radionuclides by reverse osmosis membrane have been investigated. The removal rates of radionuclides and/or detergents are presented for each process. (author)

  9. Development of an automated handwriting analysis system

    OpenAIRE

    Vikram Kamath; Nikhil Ramaswamy; Navin Karanth, P.; Vijay Desai; Kulkarni, S. M.

    2011-01-01

    In the present study a method has been proposed for the behavioral prediction of a person through automated handwriting analysis. The present work identifies the psychological traits in the writing namely size, slant and pressure, baseline, number of breaks, margins, speed of writing and spacing between the words. The handwriting is analyzed through Image Processing in MATLAB. The behavioral pattern of the person is predicted from the above traits of the handwriting. The developed system iden...

  10. ARM System Developer's Guide Designing and Optimizing System Software

    CERN Document Server

    Sloss, Andrew

    2004-01-01

    Over the last ten years, the ARM architecture has become one of the most pervasive architectures in the world, with more than 2 billion ARM-based processors embedded in products ranging from cell phones to automotive braking systems. A world-wide community of ARM developers in semiconductor and product design companies includes software developers, system designers and hardware engineers. To date no book has directly addressed their need to develop the system and software for an ARM-based system. This text fills that gap. This book provides a comprehensive description of the operation of the ARM core from a developer's perspective with a clear emphasis on software. It demonstrates not only how to write efficient ARM software in C and assembly but also how to optimize code. Example code throughout the book can be integrated into commercial products or used as templates to enable quick creation of productive software. The book covers both the ARM and Thumb instruction sets, covers Intel''s XScale Processors, ou...

  11. Health care system reform in developing countries

    Directory of Open Access Journals (Sweden)

    Wei Han

    2012-12-01

    Full Text Available This article proposes a critical but non-systematic review of recent health care system reforms in developing countries. The literature reports mixed results as to whether reforms improve the financial protection of the poor or not. We discuss the reasons for these differences by comparing three representative countries: Mexico, Vietnam, and China. First, the design of the health care system reform, as well as the summary of its evaluation, is briefly described for each country. Then, the discussion is developed along two lines: policy design and evaluation methodology. The review suggests that i background differences, such as social development, poverty level, and population health should be considered when taking other countries as a model; ii although demand-side reforms can be improved, more attention should be paid to supply-side reforms; and iii the findings of empirical evaluation might be biased due to the evaluation design, the choice of outcome, data quality, and evaluation methodology, which should be borne in mind when designing health care system reforms.

  12. Development of remote visual inspection system

    International Nuclear Information System (INIS)

    Visual inspection is one of the preliminary steps in qualification of any component. Also during the lifetime of the component, it has to see varying operating conditions. During this period the surface conditions of the component changes. Visual inspection is a useful tool for generating data of the surface conditions during pre service and in service inspection. This data is then useful in determining the extent of degradation during the service or to qualify the component for future service. The visual inspection gives the information about integrity of the component and thus aids in decision making whether repair or maintenance or some other inspection has to be carried out. This paper mainly highlights development of an inspection system to be used during steam generator lancing-Remote Visual Inspection System (RVIS). The RVIS is used to determine the steam generator tube sheet condition before and after lancing. The development of system was a challenge, considering dimensional restrains and small gap between the tubes through which tube sheet has to be seen. The RVIS was developed, fabricated, assembled and qualified on the steam generator mock up. The paper also briefs about various visual inspections carried out in the existing facilities in BARC for qualification, fault detection or reference data generation. All the visual inspections have been carried out after their qualification through mock up trials. In the end, current R and D work for characterizatio, current R and D work for characterization of images is also discussed. (author)

  13. Development of Carbon Dioxide Removal Systems for Advanced Exploration Systems

    Science.gov (United States)

    Knox, James C.; Trinh, Diep; Gostowski, Rudy; King, Eric; Mattox, Emily M.; Watson, David; Thomas, John

    2012-01-01

    "NASA's Advanced Exploration Systems (AES) program is pioneering new approaches for rapidly developing prototype systems, demonstrating key capabilities, and validating operational concepts for future human missions beyond Earth orbit" (NASA 2012). These forays beyond the confines of earth's gravity will place unprecedented demands on launch systems. They must not only blast out of earth's gravity well as during the Apollo moon missions, but also launch the supplies needed to sustain a crew over longer periods for exploration missions beyond earth's moon. Thus all spacecraft systems, including those for the separation of metabolic carbon dioxide and water from a crewed vehicle, must be minimized with respect to mass, power, and volume. Emphasis is also placed on system robustness both to minimize replacement parts and ensure crew safety when a quick return to earth is not possible. Current efforts are focused on improving the current state-of-the-art systems utilizing fixed beds of sorbent pellets by seeking more robust pelletized sorbents, evaluating structured sorbents, and examining alternate bed configurations to improve system efficiency and reliability. These development efforts combine testing of sub-scale systems and multi-physics computer simulations to evaluate candidate approaches, select the best performing options, and optimize the configuration of the selected approach, which is then implemented in a full-scale integrated atmosphere revitalization test. This paper describes the carbon dioxide (CO2) removal hardware design and sorbent screening and characterization effort in support of the Atmosphere Resource Recovery and Environmental Monitoring (ARREM) project within the AES program. A companion paper discusses development of atmosphere revitalization models and simulations for this project.

  14. Development of decommissioning engineering support system for fugen. Development of support system during actual dismantlement works

    International Nuclear Information System (INIS)

    The Advanced Thermal Reactor, Fugen Nuclear Power Station was permanently shut down in March 2003, and is now preparing for decommissioning. We have been developing Decommissioning Engineering Support System (DEXUS) aimed at planning optimal dismantlement process and carrying out dismantlement work safely and precisely. DEXUS consists of 'decommissioning planning support system' and 'dismantling support system'. The dismantling support system is developed aiming at using during actual dismantling work. It consists of three subsystems such as 'Worksite Visualization System', 'Dismantling Data Collection System' and 'Generated Waste Management System'. 'Worksite Visualization System' is a support system designed to provide the necessary information to workers during actual dismantlement works. And this system adopts AR (Augmented Reality) technology, overlapping calculation information into real world. 'Dismantling Data Collection System' is to collect necessary data for improving accuracy of decommissioning planning by evaluating work content and worker equipage, work time for dismantlement works. 'Generated Waste Management system' is a system recording necessary information by attaching the barcode to dismantled wastes or the containers. We can get the information of generated waste by recording generation place, generated time, treatment method and the contents. These subsystems enable to carry out reasonable and safe decommissioning of Fugen. In addition, we expectissioning of Fugen. In addition, we expect that those systems will be used for decommissioning of other nuclear facilities in the future. (authors)

  15. Development of 100Ci tritium handling system

    International Nuclear Information System (INIS)

    A new experimental system has been developed for use of pure tritium amounting to 100 Ci at a time. The system consists of two experimental chambers and other components such as tritium storage-supply, gas purification, isotope separation, and exhaust gas handling devices. These components provide a complete tritium circulation in the system, and hence tritium waste can be minimized for a variety of experimental works. One of the chambers is designed for experiments using molecular tritium, and the other hand tritium plasma generated with ECR discharge. A Zr-Ni alloy is applied for impurity removal from the exhaust gas from both of the experimental chambers and gas chromatography is used for the isotope separation of purified hydrogen isotope mixtures. Other kinds of gettering materials are used for tritium isotope-supply. The exhaust gas handling system has two different devices; one is a conventional wet device, consisting of a Pt-catalyst bed and a molecular sieve bed, the other a dry device using two getter beds. This paper describes the details of the system as well as its components and the results of system performance test using non-radioactive hydrogen isotopes. (author)

  16. Development of integrated analytical data management system

    International Nuclear Information System (INIS)

    The Analysis Subsection of Technical Service Section, Tokai Reprocessing Plant, Tokai Works, is engaged in analysis activities required for the management of processes and measurements in the plant. Currently, it has been desired to increase the reliability of analytical data and to perform analyses more rapidly to cope with the increasing number of analysis works. To meet this end, on-line data processing has been promoted and advanced analytical equipment has been introduced in order to enhance automization. In the present study, an integrated analytical data mangement system is developed which serves for improvement of reliability of analytical data as well as for rapid retrieval and automatic compilation of these data. Fabrication of a basic model of the system has been nearly completed and test operation has already been started. In selecting hardware to be used, examinations were made on easiness of system extension, Japanese language processing function for improving man-machine interface, large-capacity auxiliary memory system, and data base processing function. The existing analysis works wer reviewed in establishing the basic design of the system. According to this basic design, the system can perform such works as analysis of application slips received from clients as well as recording, sending, filing and retrieval of analysis results. (Nogami, K.)

  17. Solar Energy Forecast System Development and Implementation

    Science.gov (United States)

    Jascourt, S. D.; Kirk-Davidoff, D. B.; Cassidy, C.

    2012-12-01

    Forecast systems for predicting real-time solar energy generation are being developed along similar lines to those of more established wind forecast systems, but the challenges and constraints are different. Clouds and aerosols play a large role, and for tilted photovoltaic panels and solar concentrating plants, the direct beam irradiance, which typically has much larger forecast errors than global horizontal irradiance, must be utilized. At MDA Information Systems, we are developing a forecast system based on first principles, with the well-validated REST2 clear sky model (Gueymard, 2008) at its backbone. In tuning the model and addressing aerosol scattering and surface albedo, etc., we relied upon the wealth of public data sources including AERONET (aerosol optical depth at different wavelengths), Suominet (GPS integrated water vapor), NREL MIDC solar monitoring stations, SURFRAD (includes upwelling shortwave), and MODIS (albedo in different wavelength bands), among others. The forecast itself utilizes a blend of NWP model output, which must be brought down to finer time resolution based on the diurnal cycle rather than simple interpolation. Many models currently do not output the direct beam irradiance, and one that does appears to have a bias relative to its global horizontal irradiance, with equally good performance attained by utilizing REST2 and the model global radiation to estimate the direct component. We will present a detailed assessment of various NWP solar energy products, evaluating forecast skill at a range of photovoltaic installations.

  18. Development of Sic Gas Sensor Systems

    Science.gov (United States)

    Hunter, G. W.; Neudeck, P. G.; Okojie, R. S.; Beheim, G. M.; Thomas, V.; Chen, L.; Lukco, D.; Liu, C. C.; Ward, B.; Makel, D.

    2002-01-01

    Silicon carbide (SiC) based gas sensors have significant potential to address the gas sensing needs of aerospace applications such as emission monitoring, fuel leak detection, and fire detection. However, in order to reach that potential, a range of technical challenges must be overcome. These challenges go beyond the development of the basic sensor itself and include the need for viable enabling technologies to make a complete gas sensor system: electrical contacts, packaging, and transfer of information from the sensor to the outside world. This paper reviews the status at NASA Glenn Research Center of SiC Schottky diode gas sensor development as well as that of enabling technologies supporting SiC gas sensor system implementation. A vision of a complete high temperature microfabricated SiC gas sensor system is proposed. In the long-term, it is believed that improvements in the SiC semiconductor material itself could have a dramatic effect on the performance of SiC gas sensor systems.

  19. Development of portable superconducting bulk magnet system

    International Nuclear Information System (INIS)

    A magnetic drug delivery system (MDDS) has recently been developed enabling magnetic seeded drugs to be navigated around the diseased parts of the human body. To improve the magnetic drug delivery performance, a portable superconducting bulk magnet system with strong magnetic fields has also been developed. This magnet system primarily consists of small bulk high-temperature superconductors and a compact Stirling-cycle cryocooler. The materials used in the high-temperature superconductors are rare earth 123 single domain compounds (GdBaCuO). The main body of the magnet is 9.5 kg and 740 mm in length. In this study, a bulk magnet was successfully activated using field-cooling magnetization under a superconducting solenoid magnet. The magnetic flux densities at the surface of the vacuum chambers that contain the bulk magnets reached 5.07 T and 6.76 T under the static fields of 6 T and 10 T, respectively. We clarified that the magnetic gradient was approximately 10 T/m at a position 50 mm from the surface of the vacuum chambers. This operating bulk magnet system is portable and can be easily transported via car over long distances. (author)

  20. Correlator system development and flight testing

    Science.gov (United States)

    Goldstein, Dennis H.; Augustus, Eric P.; Champigny, Norman E.; Lacey, Donald J.; Wangler, Richard J.; Karins, James P.; Ross, William E.; Kelly, Louis G., Jr.; Lucas, John R.; Mills, Stuart A.

    1993-10-01

    The development of an optical correlator system and flight tests to be conducted from a remotely piloted vehicle (RPV) are described. The optical processor is based on laser gyroscope construction techniques and relies on 128 X 128 reflective-mode magneto-optic spatial light modulators for both the input image and spatial filter insertion. The input image is obtained from a visible camera in the nose of the RPV. The processing system incorporates Kalman's invariant filters. The output of the correlator is through a 128 X 128 high speed CCD camera. The correlator system also includes image processing and all electronic drivers. The optical package occupies a volume less than 25 in3 while the whole processor package is less than 1 ft3 and weighs less than 40 lbs, and is ruggedized for temperature, shock, and vibration. The RPV, Eglin Air Force Base test range facilities, tower tests, telemetry, and training set acquisition are discussed.

  1. Development of an automated handwriting analysis system

    Directory of Open Access Journals (Sweden)

    Vikram Kamath

    2011-09-01

    Full Text Available In the present study a method has been proposed for the behavioral prediction of a person through automated handwriting analysis. The present work identifies the psychological traits in the writing namely size, slant and pressure, baseline, number of breaks, margins, speed of writing and spacing between the words. The handwriting is analyzed through Image Processing in MATLAB. The behavioral pattern of the person is predicted from the above traits of the handwriting. The developed system identifies handwriting closely which may not be possible for a graphologist. It is real time and involves less image preprocessing. The proposed system is calibrated with manual analysis. The results obtained through the system are in good agreement to more than 80 percent of the cases with ideal manual analysis.

  2. Implementing Life Cycle Assessment in systems development.

    DEFF Research Database (Denmark)

    Bhander, Gurbakhash Singh; Hauschild, Michael Zwicky

    2003-01-01

    Today's industry is being forced to consider the environmental performance of its products concurrently with traditional requirements such as quality, price or functional performance. The Life Cycle Assessment (LCA) technique has been identified as a powerful tool to calculate environmental impacts derived from products and system, and calculate resource consumptions. However, the complexity of LCA poses restrictions to its use in current product and system development given the need for a reduction in product development cycle time which is needed to meet the increasing competitive pressures and the rapid changes in markets for many products. The overall aim of the paper is to provide an understanding of the environmental issues involved in the early stages of product development and the capacity of life cycle assessment techniques to address these issues. The paper aims to outline the problems for the designer in evaluating the environmental benignity of the product from the outset and to provide the designer with a framework for decision support based on the performance evaluation at different stages of the design process. The overall aim of this paper is to produce an in-depth understanding of the barriers to implementation of LCA by developers of products, and of the opportunities for introducing environmental criteria in the design process through meeting the information requirements of the designer on the different life cycle stages, producing an in-depth understanding of the attitudes of practitioners among product developers to the subject area, and an understanding of possible future directions for product development. An Environmentally Conscious Design method is introduced and trade-offs are presented between design degrees of freedom and environmental solutions. It also discusses a number of possibilities which can be introduced in the design stage compared to the other life cycle stages of the product system. The paper collects experiences and ideas around the state-of-the-art in eco-design, from literature and personal experience and further provides eco-design life cycle assessment strategies. The paper reviews the current environmental evaluation practices with respect to product life cycles. As a number of deficiencies in LCA are identified, strategies are presented to provide a solution to many of the deficiencies. The result of the paper is a definition of the requirements for performance measurement techniques and a performance measurement environment necessary to support life cycle evaluation throughout the evaluation of early stages of a product system.

  3. Development of the Medium Energy Linac Systems

    International Nuclear Information System (INIS)

    The main purposes of the proton engineering frontier project is developing a proton linac which accelerates 20 mA proton beams up to 100 MeV and supplying 20 MeV and 100 MeV proton beams to the user groups. The project 'Development of the medium energy linac systems' is aiming to design the 100 MeV proton linac, to construct an accelerating cavity, to design a MEBT system, and to develop a energy measurement system. The 100 MeV linac consists of 20 DTL tanks which are operated by five additional klystrons. The focusing lattice is FFDD as the 20 MeV DTL. However the hollow conductors are used for coils of the quadrupole magnets. The shape of the drift tubes in the new tanks is changed to compensate the reduction of the accelerating efficiency in the high energy region. For example, the face angle of drift tubes begins at 40 degrees. The bore radius is selected as 10 mm in order to eliminate beam loss in the beam line. We can obtain the 100 MeV proton beams by using these accelerating structure. We have designed some of the tanks in detail. It covers the modification of the structure by including the stem, post-coupler, and sulg-tuner effects, the error analysis, the thermal and structure analysis, the drift tube design, the magnet design, the various ports design, the support structure design, the end-plate design, etc. Now the first DTL tank is constructed by a local company. An beam extraction system is essential after 20 MeV DTL in order to supply 20 MeV proton beams. Since there are no focusing elements in the structure, the beam should be spread out. The MEBT which consists of two 3-cell DTL tanks is designed to control the beam size in the beam extraction system by magnets in the first tank and to transversely match the beam into the next DTL by magnets in the the second tank. The longitudinal matching is done by the RF in both tanks. We have also developed an energy measurement system using the time of flight method

  4. Development of genetic systems for the mycobacteria.

    Science.gov (United States)

    Jacobs, W R; Snapper, S B; Lugosi, L; Jekkel, A; Melton, R E; Kieser, T; Bloom, B R

    1989-01-01

    Requisite to a detailed understanding of the molecular basis of bacterial pathogenesis is a genetic system which allows for the transfer, mutation, and expression of specific genes. Genetic analysis of mycobacteria has been exceedingly difficult since the mycobacteria grow slowly and no natural efficient method of gene transfer within the pathogenic has thus far been found. Using a molecular genetic approach, we have developed both the vectors and the methodology for efficient gene transfer in the mycobacteria. Initially, a novel of type of mycobacteriophage vector was developed, termed a shuttle phasmid. This hybrid shuttle vector replicates in Escherichia coli as a plasmid and in mycobacteria as a phage, capable of introducing foreign DNA into a wide variety of mycobacterial species. A set of shuttle phasmids, constructed from a temperate mycobacteriophage, retained their ability to lysogenize their mycobacterial hosts and could thus introduce foreign DNA stably into mycobacterial cells. An E. coli gene conferring kanamycin-resistance was cloned into these vectors and shown to express in the mycobacteria, thus providing the first selectable marker gene for subsequent genetic studies. Using kanamycin-resistance gene as a selection, the M. fortuitum plasmid pAL5000 replicon, and electroporation; a plasmid transformation system has been developed for both M. smegmatis and BCG. We now plan to use these phage and plasmid systems to analyze, genetically, the virulence attributes of the pathogenic mycobacteria. In addition, by introducing and expressing foreign antigens in BCG, we hope to develop a novel recombinant multi-vaccine vehicle capable of conferring immunity to a variety of bacterial, viral, and parasitic pathogens. PMID:2503991

  5. Recent developments of the TOPAZ Arctic system

    Science.gov (United States)

    Bertino, L.; Sakov, P.; Counillon, F.

    2009-04-01

    The TOPAZ North Atlantic system has been running in near-real time weekly forecasts since January 2003 using the HYCOM model and the Ensemble Kalman Filter (EnKF), TOPAZ is as far as we know the only ocean forecast system running in real-time a dynamically evolving error covariance (Kalman filter type). It assimilates sea level anomalies from CLS, sea surface temperatures from NOAA, sea-ice concentrations from NSIDC (AMSR-E), sea-ice drift from CERSAT/Ifremer and Argo temperature and salinity profiles from Coriolis/Ifremer. The third version of the system is now exploited within met.no's operational suite with a horizontal resolution between 11 km and 16 km. The forecast numerical data are served on OPEnDAP/THREDDS. The presentation will describe recent developments of the modelling and assimilation system and plans for the 20-years reanalysis to be carried out within MyOcean as well as the users applications of the TOPAZ system. TOPAZ contributes to the Arctic ROOS and EuroGOOS.

  6. Development and application of earth system models.

    Science.gov (United States)

    Prinn, Ronald G

    2013-02-26

    The global environment is a complex and dynamic system. Earth system modeling is needed to help understand changes in interacting subsystems, elucidate the influence of human activities, and explore possible future changes. Integrated assessment of environment and human development is arguably the most difficult and most important "systems" problem faced. To illustrate this approach, we present results from the integrated global system model (IGSM), which consists of coupled submodels addressing economic development, atmospheric chemistry, climate dynamics, and ecosystem processes. An uncertainty analysis implies that without mitigation policies, the global average surface temperature may rise between 3.5 °C and 7.4 °C from 1981-2000 to 2091-2100 (90% confidence limits). Polar temperatures, absent policy, are projected to rise from about 6.4 °C to 14 °C (90% confidence limits). Similar analysis of four increasingly stringent climate mitigation policy cases involving stabilization of greenhouse gases at various levels indicates that the greatest effect of these policies is to lower the probability of extreme changes. The IGSM is also used to elucidate potential unintended environmental consequences of renewable energy at large scales. There are significant reasons for attention to climate adaptation in addition to climate mitigation that earth system models can help inform. These models can also be applied to evaluate whether "climate engineering" is a viable option or a dangerous diversion. We must prepare young people to address this issue: The problem of preserving a habitable planet will engage present and future generations. Scientists must improve communication if research is to inform the public and policy makers better. PMID:22706645

  7. The Mediterranean Forecasting System: recent developments

    Science.gov (United States)

    Tonani, Marina; Oddo, Paolo; Korres, Gerasimos; Clementi, Emanuela; Dobricic, Srdjan; Drudi, Massimiliano; Pistoia, Jenny; Guarnieri, Antonio; Romaniello, Vito; Girardi, Giacomo; Grandi, Alessandro; Bonaduce, Antonio; Pinardi, Nadia

    2014-05-01

    Recent developments of the Mediterranean Monitoring and Forecasting Centre of the EU-Copernicus marine service, the Mediterranean Forecasting System (MFS), are presented. MFS provides forecast, analysis and reanalysis for the physical and biogeochemical parameters of the Mediterranean Sea. The different components of the system are continuously updated in order to provide to the users the best available product. This work is focus on the physical component of the system. The physical core of MFS is composed by an ocean general circulation model (NEMO) coupled with a spectral wave model (Wave Watch-III). The NEMO model provides to WW-III surface currents and SST fields, while WW-III returns back to NEMO the neutral component of the surface drag coefficient. Satellite Sea Level Anomaly observations and in-situ T & S vertical profiles are assimilated into this system using a variational assimilation scheme based on 3DVAR (Dobricic, 2008) . Sensitive experiments have been performed in order to assess the impact of the assimilation of the latest available SLA missions, Altika and Cryosat together with the long term available mission of Jason2. The results show a significant improvement of the MFS skill due to the multi-mission along track assimilation. The primitive equations module has been recently upgraded with the introduction of the atmospheric pressure term and a new, explicit, numerical scheme has been adopted to solve the barotropic component of the equations of motion. The SLA satellite observations for data assimilation have been consequently modified in order to account for the new atmospheric pressure term introduced in the equations. This new system has been evaluated using tide gauge coastal buoys and the satellite along track data. The quality of the SSH has improved significantly while a minor impact has been observed on the other state variables (temperature, salinity and currents). Experiments with a higher resolution NWP (numerical weather prediction) forcing provided by the COSMO-MED system (provided by the Italian Meteorological Office), have been performed and a pre-operational 3-day forecast production system has been developed. The comparison between this system and the official one forced by the ECMWF NWP data will be discussed.

  8. Advanced systems: Status and development prospects

    International Nuclear Information System (INIS)

    World reserves of coal, uranium, thorium and thermonuclear fuel (deuterium and lithium) are sufficient to provide mankind with energy for many centuries. The rate of increase in demand is unlikely to be a limiting factor, and it would seem that any ''limits to growth'' will be dictated by other, in particular ecological, factors. In the last two decades, world power production has developed a structure in which a predominant place is occupied by oil and gas; this will have to change as a result of the marked depletion of oil resources and the enhanced role played in the fuel balance by power from coal and nuclear fission, on which, it would seem, the long-term growth of world energy production will be based. The contribution of nuclear fission power towards meeting world energy needs will depend on a number of factors, the most important of which from a long-term point of view is the time and rate of introduction of advanced nuclear power systems and fuel cycles with high nuclear fuel surpluses (breeding ratios). The results of almost 30 years of development of nuclear power with thermal-neutron reactors may serve as a basis for the analysis, evaluation and forecasting of the development of advanced systems. (author)

  9. Development of the plutonium oxide vitrification system

    International Nuclear Information System (INIS)

    Repository disposal of plutonium in a suitable, immobilized form is being considered as one option for the disposition of surplus weapons-usable plutonium. Accelerated development efforts were completed in 1997 on two potential immobilization forms to facilitate downselection to one form for continued development. The two forms studied were a crystalline ceramic based on Synroc technology and a lanthanide borosilicate (LaBS) glass. As part of the glass development program, melter design activities and component testing were completed to demonstrate the feasibility of using glass as an immobilization medium. A prototypical melter was designed and built in 1997. The melter vessel and drain tube were constructed of a Pt/Rh alloy. Separate induction systems were used to heat the vessel and drain tube. A Pt/Rh stirrer was incorporated into the design to facilitate homogenization of the melt. Integrated powder feeding and off-gas systems completed the overall design. Concurrent with the design efforts, testing was conducted using a plutonium surrogate LaBS composition in an existing (near-scale) melter to demonstrate the feasibility of processing the LaBS glass on a production scale. Additionally, the drain tube configuration was successfully tested using a plutonium surrogate LaBS glass

  10. Development of the plutonium oxide vitrification system

    Energy Technology Data Exchange (ETDEWEB)

    Marshall, K.M.; Marra, J.C.; Coughlin, J.T.; Calloway, T.B.; Schumacher, R.F.; Zamecnik, J.R.; Pareizs, J.M.

    1998-01-01

    Repository disposal of plutonium in a suitable, immobilized form is being considered as one option for the disposition of surplus weapons-usable plutonium. Accelerated development efforts were completed in 1997 on two potential immobilization forms to facilitate downselection to one form for continued development. The two forms studied were a crystalline ceramic based on Synroc technology and a lanthanide borosilicate (LaBS) glass. As part of the glass development program, melter design activities and component testing were completed to demonstrate the feasibility of using glass as an immobilization medium. A prototypical melter was designed and built in 1997. The melter vessel and drain tube were constructed of a Pt/Rh alloy. Separate induction systems were used to heat the vessel and drain tube. A Pt/Rh stirrer was incorporated into the design to facilitate homogenization of the melt. Integrated powder feeding and off-gas systems completed the overall design. Concurrent with the design efforts, testing was conducted using a plutonium surrogate LaBS composition in an existing (near-scale) melter to demonstrate the feasibility of processing the LaBS glass on a production scale. Additionally, the drain tube configuration was successfully tested using a plutonium surrogate LaBS glass.

  11. LPP source system development for HVM

    Science.gov (United States)

    Brandt, David C.; Fomenkov, Igor V.; Ershov, Alex I.; Partlo, William N.; Myers, David W.; Böwering, Norbert R.; Farrar, Nigel R.; Vaschenko, Georgiy O.; Khodykin, Oleh V.; Bykanov, Alexander N.; Hoffman, Jerzy R.; Chrobak, Christopher P.; Srivastava, Shailendra N.; Ahmad, Imtiaz; Rajyaguru, Chirag; Golich, Daniel J.; Vidusek, David A.; De Dea, Silvia; Hou, Richard R.

    2009-03-01

    Laser produced plasma (LPP) systems have been developed as a viable approach for the EUV scanner light source for optical imaging of circuit features at sub-32nm and beyond nodes on the ITRS roadmap. This paper provides a review of development progress and productization status for LPP extreme-ultra-violet (EUV) sources with performance goals targeted to meet specific requirements from leading scanner manufacturers. We present the latest results on power generation, stable and efficient collection, and clean transmission of EUV light through the intermediate focus. We report on measurements taken using a 5sr collector optic on a production system. Power transmitted to intermediate focus (IF) is shown. The lifetime of the collector mirror is a critical parameter in the development of extreme ultraviolet LPP lithography sources. Deposition of target material as well as sputtering of the multilayer coating or implantation of incident particles can reduce the reflectivity of the mirror coating during exposure. Debris mitigation techniques are used to inhibit damage from occuring, the results of these techniques are shown. We also report on the fabrication of 5sr collectors and MLM coating reflectivity, and on Sn droplet generators with droplet size down to 30?m diameter.

  12. Flammability test for sunglasses: developing a system

    Science.gov (United States)

    Magri, Renan; Ventura, Liliane

    2014-02-01

    Recent investigations show the need for certificating sunglasses to ensure the safety and health to population. The Brazilian Standard ABNT NBR 15111 regulates features to sunglasses, however, there is not a sunglasses certification office in Brazil, therefore, our lab has been developing several equipment for sunglasses testing. This work refers to one of them: the flammability test system for sunglasses in compliance with the NBR 15111. The standard provides requirements for the flammability test procedure which requires that the equipment must operate at a temperature of 650 °C +/- 20 °C the end of a steel rod of 300 mm length and 6 mm diameter should be heated and pressed over the surface of the lenses for five seconds; the flammability is checked by visual inspection. The furnace is made of ceramic. We used a power electronic circuit to control the power in the furnace using ON/OFF mode and for measuring the temperature, we used a K-type thermocouple. A stepper motor with pulley lifts the steel rod. The system reaches the working temperature in 15 minutes for a step input of 61 V in open loop system. The electronics control are under development in order to shorten the time necessary to reach the working temperature and maintain the temperature variation in the furnace within the limits imposed by the standard as next steps.

  13. Development of portable superconducting bulk magnet system

    International Nuclear Information System (INIS)

    Recently a magnetic drug delivery system (MDDS) has been developing to navigate magnetic seeded drugs around diseased parts of the human body. To improve the magnetic drug delivery performance, a portable high temperature superconducting (HTS) bulk magnet system with high magnetic fields has been developed. This magnet system mainly consists of small bulk high temperature superconductors and a compact cryocooler. The materials of the high temperature superconductor are rare earth 123 single domain compounds (Gd-Ba-Cu-O). The bulk magnet was activated successfully using field-cooling magnetization under the superconducting solenoid magnet. The magnetic flux densities at the surface of the vacuum chambers that contain bulk magnets reached 5.07 T and 6.76 T using the static magnetic fields of 6 T and 10 T superconducting solenoid magnets, respectively. A cryocooler cooled them to 38.1 K and 39.1 K. It was clarified that the magnetic gradient was approximately 10 T/m at a position located 50 mm from the surface of the vacuum chambers.

  14. EU developments of the ITER ECRH system

    International Nuclear Information System (INIS)

    The EU will be providing the largest contribution to the ITER electron cyclotron (EC) heating and current drive (H and CD) system (20 MW, CW at 170 GHz). The contribution includes one third of the H and CD gyrotrons, their associated power supplies and four upper port launcher antennas. In all areas of participation, the EU EC partnership (coordinated by the European Fusion Development Agreement) aims toward advancing the technology, while staying within a specified cost envelope. This is portrayed in the co-axial gyrotron development that offers the potential to double the output power per source (2.0 MW), increasing the delivered power for a fixed number of auxiliary systems. The EU partnerships also attempt to increase performance for the entire EC system, in particular the launching antennas. The proposed front steering launcher design offers greater control of MHD activity than the previous remote steering design and opens up the possibility of an enhanced performance UL. The EC physics requirements are repartitioned between the upper and equatorial launchers for a synergetic balance, which increases the EC physics capabilities while relaxing some of the engineering requirements

  15. Developments towards a fully automated AMS system

    International Nuclear Information System (INIS)

    The possibilities of computer-assisted and automated accelerator mass spectrometry (AMS) measurements were explored. The goal of these efforts is to develop fully automated procedures for 'routine' measurements at the Vienna Environmental Research Accelerator (VERA), a dedicated 3-MV Pelletron tandem AMS facility. As a new tool for automatic tuning of the ion optics we developed a multi-dimensional optimization algorithm robust to noise, which was applied for 14C and 10Be. The actual isotope ratio measurements are performed in a fully automated fashion and do not require the presence of an operator. Incoming data are evaluated online and the results can be accessed via Internet. The system was used for 14C, 10Be, 26Al and 129I measurements

  16. Development of the Open Items Tracking System

    International Nuclear Information System (INIS)

    The West Valley Demonstration Project, located on the site of the only commercial nuclear fuel reprocessing facility to have operated in USA, has the directed objectives of solidifying the high-level radioactive waste into a durable, solid form for shipment; decontaminating and decommissioning the tanks and facilities; and disposing of the resulting low-level and transuranic wastes. Since an escalating trend of open work items was noticed in the Fall of 1988, and there was no control mechanism for tracking and closing the open items, a Work Control System was developed for this purpose. It is self-contained system on a mainframe ARTEMIS 9000, which tracks, monitors, and closes out external commitments in a timely manner. Audits, surveillances, site appraisals, preventive maintenance, instrument calibration recall, and scheduling are covered

  17. Developing Information System on Lunar Crescent Observations

    Directory of Open Access Journals (Sweden)

    T. Hidayat

    2010-03-01

    Full Text Available We present a progress report on the development of information system of lunar crescent astronomical observations which will be largely accessible for public domain. This consists of calculations of the Moon’s ephemeris as well as systematic real-time lunar crescent observations. A well suited small telescope, equipped with a simple digital detector, is connected to a server to provide information on lunar crescent observations. The system has been used and worked well. The only constraint is poor weather condition. Network of small telescopes, installed at various locations in Indonesia, are currently planned to provide plethora of data. In the long term, this will be used to help to determine the astronomical visibility criteria of lunar crescent for Islamic calendar.

  18. The development of a neurosurgical navigation system

    International Nuclear Information System (INIS)

    A Computer Assisted Neurosurgical Navigation System (CANS Navigator) has been developed, which assists neurosurgeons in surgery by utilizing images from highly advanced medical imaging devices. During a surgical procedure, the positional and directional information about the surgical, tools can be confirmed by observing their location on the CT or MR images on the CRT monitor. Applying magnetic field technology to position measurement, the position sensor attached to the surgical tool can be made small and light. As a result, no interference occurs with the surgical procedure. Performed on important fine vessels and nerves, neurosurgery requires precision techniques often lasting many hours. Therefore, the surgeons bear great loads physically and psychologically. Because understanding the location of the diseased part and the various organs can be made easy, the use of this system reduces the workload on surgeons and helps effect more accurate and safer surgery. (author)

  19. Development of a microbeam scanning system

    International Nuclear Information System (INIS)

    High energy ion microbeam is a powerful analytical tool by combining various ion beam analysis techniques and is also attractive as a direct lithographic technique. We have developed a microbeam scanning system which is indispensable to these purposes. The scanning system is composed of a set of electrostatic deflectors, HV amplifiers and a function generator. Microbeams are scanned with a corresponding scanning pattern translated from a bitmap file for an efficient irradiation. The spacing between patterns to pattern was made by moving the beam at the fastest speed of the beam scanner. The irradiation dose was monitored pixel by pixel with RBS. The technique is applicable to an efficient ion beam analysis by combining STIM image. (author)

  20. Development of rationalized system treating floor drain

    International Nuclear Information System (INIS)

    Radioactive liquid wastes generated at BWR plants are collected and treated as required. These days, however, generation of floor drain has deceased and HFF (Hollow Fiber Filter) has experienced a wide applicability to several kinds of liquid wastes. We should consider that the floor drain can be mixed and diluted with equipment drain and be purified by HFF. That enables some of the sumps and long priming pipes to be combined. From this point of view, we have developed a highly rationalized waste liquid system. We have evaluated the applicability of this system after an investigation into the generation and properties of floor drain and equipment drain at the latest BWR'S and an on-site test at a typical BWR. (author)

  1. Development of PWR CRDM Data Analyzing System

    International Nuclear Information System (INIS)

    Control Rod Drive Mechanisms (CRDMs) play an important role in nuclear power plants, and their reliability impacts plant operation and reactor safety. CRDM performance might decline when the CRDM has been operated for a long time. CRDM operation time is expected to increase significantly depending on the variations of plant operation, so it is desirable to upgrade the preventive maintenance of CRDMs and Drive Lines through the periodic inspection and condition monitoring. Furthermore, in the case of CRDM malfunction, it is necessary to cope immediately with the problem, based on technical judgement. The CRDM Data Analyzing System has been developed in order to achieve the high reliability of CRDMs by predicting malfunctions. (author)

  2. Development of a THz spectroscopic imaging system

    International Nuclear Information System (INIS)

    We have developed a real-time THz imaging system based on the two-dimensional (2D) electro-optic (EO) sampling technique. Employing the 2D EO-sampling technique, we can obtain THz images using a CCD camera at a video rate of up to 30 frames per second. A spatial resolution of 1.4 mm was achieved. This resolution was reasonably close to the theoretical limit determined by diffraction. We observed not only static objects but also moving ones. To acquire spectroscopic information, time-domain images were collected. By processing these images on a computer, we can obtain spectroscopic images. Spectroscopy for silicon wafers was demonstrated

  3. Development of a laundry radwaste treatment system

    Energy Technology Data Exchange (ETDEWEB)

    Kim, J.B.; Park, J.K.; Park, S.M.; Ahn, H.J.; Song, M.J. [Korea Electric Power Corp., Research Institute, Taejon (Korea, Republic of)

    1998-07-01

    Fundamental bench tests have been performed to develop a radioactive laundry radwaste treatment system, involving ozone/activated carbon, reverse osmosis membrane, and ion exchanger. A pre-treatment technique was employed for the removal of detergent, using a ozonization (ozone/H{sub 2}O{sub 2}). Adsorption of detergent and radionuclides by various commercial adsorbents and removal of radionuclides by reverse osmosis membrane have been investigated. The removal rates of radionuclides and/or detergents are presented for each process. (author)

  4. Development techniques of computerized maintenance Management system

    Energy Technology Data Exchange (ETDEWEB)

    Oh, Yon Woo; Kim, S.D.; Soong, W.S.; Kim, G.H.; Oh, W.H.; Kim, Y.G

    2000-05-01

    Normal operation of the facility is one of the key factors in the accomplishments of research goals. As confirmed by a case study of the influence of the facility operation condition on the research results, emphasis should be put on the facility preserve management. Facilities should be maintained in solid operational condition and their malfunctions should be repaired as soon as possible. The purpose of this project is to make propositions on the development of the facility preserve management system which is to maximize the efficiency of the budget execution, manpower organization and maintenance planning, and is to minimize the duration of the operational pause due to malfunctions with the least disbursement.

  5. Development and Control of a Non Linear Magnetic Levitation System

    OpenAIRE

    Sanjeevi Gandhi, A.; Reshma Angelene Jose

    2013-01-01

    Nowadays, studies to develop and control non linear systems is of great significance. Magnetic Levitation System has gained considerable interests due to its great practical importance in different engineering fields In this paper an electromagnetic levitation system was developed and mathematical model for the system was derived. The developed system was controlled manually.

  6. Development and Control of a Non Linear Magnetic Levitation System

    Directory of Open Access Journals (Sweden)

    A Sanjeevi Gandhi

    2013-06-01

    Full Text Available Nowadays, studies to develop and control non linear systems is of great significance. Magnetic Levitation System has gained considerable interests due to its great practical importance in different engineering fields In this paper an electromagnetic levitation system was developed and mathematical model for the system was derived. The developed system was controlled manually.

  7. Development of NRU reflector wall inspection system

    International Nuclear Information System (INIS)

    In 2009 May, the National Research Universal (NRU) calandria leaked. During the next year, the calandria was inspected with six new Non-Destructive Evaluation (NDE) techniques to determine the extent of the corrosion, repaired, and finally the repair was inspected with four additional new NDE techniques before the reactor was returned to service. The calandria is surrounded by a light-water reflector vessel fabricated from the same material as the calandria vessel. Concerns that the same corrosion mechanism had damaged the reflector vessel led to the development of a system to inspect the full circumference of the reflector wall for corrosion damage. The inspection region could only be accessed through 64 mm diameter ports, was 10 m below the port, and had to be inspected from the corroded surface. The ultrasonic technique was designed to produce a closely spaced wall thickness (WT) grid over an area of approximately 5 m2 on the corroded surface using a very small probe holder. This paper describes the Reflector Wall Inspection (RWI) development project and the system that resulted. (author)

  8. Development of a Universal Waste Management System

    Science.gov (United States)

    Baccus, Shelley; Broyan, James L., Jr.

    2013-01-01

    A concept for a Universal Waste Management System (UWMS) has been developed based on the knowledge gained from over 50 years of space travel. It is being designed for Commercial Orbital Transportation Services (COTS) and Multi ]Purpose Crew Vehicle (MPCV) and is based upon the Extended Duration Orbiter (EDO) commode. The UMWS was modified to enhance crew interface and reduce volume and cost. The UWMS will stow waste in fecal canisters, similar to the EDO, and urine will be stowed in bags for in orbit change out. This allows the pretreated urine to be subsequently processed and recovered as drinking water. The new design combines two fans and a rotary phase separator on a common shaft to allow operation by a single motor. This change enhances packaging by reducing the volume associated with an extra motor, associated controller, harness, and supporting structure. The separator pumps urine to either a dual bag design for COTS vehicles or directly into a water reclamation system. The commode is supported by a concentric frame, enhancing its structural integrity while further reducing the volume from the previous design. The UWMS flight concept development effort is underway and an early output of the development will be a ground based UMWS prototype for manned testing. Referred to as the Gen 3 unit, this prototype will emulate the crew interface included in the UWMS and will offer a great deal of knowledge regarding the usability of the new design, allowing the design team the opportunity to modify the UWMS flight concept based on the manned testing.

  9. Development of Shimadzu digital subtraction system

    International Nuclear Information System (INIS)

    Shimadzu has recently developed a digital subtraction system. It can perform intra-arterial digital subtraction angiography (DSA) using low concentration of contrast medium, or can visualize arteries with intravenuous injection. It can extremely reduce patient's pain in angiography. Image quality of DSA has been much improved by the development of high quality image amplifiers, improvement of signal-to-noise ratio of the x-ray television unit and the development of digital disk recorders. The peak-hold subtraction method that is now under clinical study presents images of blood vessels as the trace of the flow of contrast medium. The maximum-hold memory where the maximum value of the brightness in some period is stored for every picture element is subtracted from the minimum-hold memory where the minimum value is stored, and thus images of blood vessels can be obtained. Hardware of this method is rather simple and it is expected that the amount of contrast medium may be reduced or x-ray dose of the patient may be decreased. (author)

  10. Development of Reactor Trip Database Management System

    International Nuclear Information System (INIS)

    The generic reference of initiating event frequency for domestic PSAs has been used by 'Advanced Light Water Reactor (ALWR) Utility Requirements Document (URD)'issued by EPRI. The needs for specific database of the initiating event for domestic nuclear power plants arise as their operating experience has accumulated. Generally, the data for initiating event are collected by the analysis of unplanned reactor scram. Therefore, a database program for systemic collection of reactor trip event was present for the efficient management of those data. Recently, NUREG-5750 was published and provides state-of-art initiating event data as well as new manner in data classification. The specific database developed in this work is determined to follows the basic structure of NUREG-5750. The approach presented in this work was to: review current data structure and state, establish a proper DB structure, analyse new generic data with the specific data which are collected in the developed DB. Particularly, the developed DB for initiating events would be incorporated into the overall DB project which includes all kinds of components data used in PSA

  11. Development of the environmental data management system

    International Nuclear Information System (INIS)

    The recent society requires business activities with environmental consideration to every enterprise. Also, Japanese laws require those activities. For example, 'Law Concerning the Promotion of Business Activities with Environmental Consideration by Specified Corporations, etc, by Facilitating Access to Environmental Information, and Other Measures' (Environmental Consideration Law) mandates publication of a report relating to the activities of environmental consideration to each enterprise above designated size. 'Act on the Rational Use of Energy' mandates the report of the results of energy consumption and the long-term plan of the rational use of energy. Moreover, 'Act on Promotion of Global Warming Countermeasures' mandates the report of the greenhouse gas emissions. In addition to those, 'Water Pollution Control Law', 'Waste Management and Public Cleaning Law' and other environmental laws as well as environmental ordinances require business activities with environmental consideration to all companies. So, it is very important for Japan Atomic Energy Agency (JAEA) to report business activities with environmental consideration in order to build up trustful relations with the nation and communities. The Environmental Data Management System has been developed as the data base of business activities with environmental consideration in JAEA and as the means to promote the activities at every site and office of JAEA. This report summarizes the structure of the Environmental Data Management System, kinds of environmental performance data treated by the system, and gathering methods of the data. (author)

  12. Development of Ultrasonic Wave Propagation Imaging System

    International Nuclear Information System (INIS)

    Laser-based ultrasonic sensing requires the probe with fixed fecal length, but this requirement is not essential in laser-based ultrasonic generation. Based on this fact, we designed a pulsed laser-based ultrasonic wave propagation imaging (UWPI) system with a tilting mirror system for rapid scanning of target, and an in-line band-pass filtering capable of ultrasonic mode selection. 1D-temporal averaging, 2D-spatial averaging, and 3D-data structure building algorithms were developed far clearer results allowing fur higher damage detectability. The imaging results on a flat stainless steel plate were presented in movie and snapshot formats which showed the propagation of ultrasound visible as a concentric wave field emerging from the location of an ultrasonic sensor. A hole in the plate with a diameter of 1 mm was indicated by the scattering wave fields. The results showed that this robust UWPI system is independent of focal length and reference data requirements.

  13. Development of Ultrasonic Wave Propagation Imaging System

    Energy Technology Data Exchange (ETDEWEB)

    Chia, Chen Ciang; Lee, Jung Ryul [Chonbuk National University, Jeonju (Korea, Republic of); Kim, Jong Heon [Agency for Defense Development, Chungju (Korea, Republic of)

    2009-08-15

    Laser-based ultrasonic sensing requires the probe with fixed fecal length, but this requirement is not essential in laser-based ultrasonic generation. Based on this fact, we designed a pulsed laser-based ultrasonic wave propagation imaging (UWPI) system with a tilting mirror system for rapid scanning of target, and an in-line band-pass filtering capable of ultrasonic mode selection. 1D-temporal averaging, 2D-spatial averaging, and 3D-data structure building algorithms were developed far clearer results allowing fur higher damage detectability. The imaging results on a flat stainless steel plate were presented in movie and snapshot formats which showed the propagation of ultrasound visible as a concentric wave field emerging from the location of an ultrasonic sensor. A hole in the plate with a diameter of 1 mm was indicated by the scattering wave fields. The results showed that this robust UWPI system is independent of focal length and reference data requirements.

  14. Power Systems Development Facility. Environmental Assessment

    Energy Technology Data Exchange (ETDEWEB)

    1993-06-01

    The objective of the PSDF would be to provide a modular facility which would support the development of advanced, pilot-scale, coal-based power systems and hot gas clean-up components. These pilot-scale components would be designed to be large enough so that the results can be related and projected to commercial systems. The facility would use a modular approach to enhance the flexibility and capability for testing; consequently, overall capital and operating costs when compared with stand-alone facilities would be reduced by sharing resources common to different modules. The facility would identify and resolve technical barrier, as well as-provide a structure for long-term testing and performance assessment. It is also intended that the facility would evaluate the operational and performance characteristics of the advanced power systems with both bituminous and subbituminous coals. Five technology-based experimental modules are proposed for the PSDF: (1) an advanced gasifier module, (2) a fuel cell test module, (3) a PFBC module, (4) a combustion gas turbine module, and (5) a module comprised of five hot gas cleanup particulate control devices. The final module, the PCD, would capture coal-derived ash and particles from both the PFBC and advanced gasifier gas streams to provide for overall particulate emission control, as well as to protect the combustion turbine and the fuel cell.

  15. Web-based Core Design System Development

    International Nuclear Information System (INIS)

    The selection of a loading pattern is one of core design processes in the operation of a nuclear power plant. A potential new loading pattern is identified by selecting fuels that to not exceed the major limiting factors of the design and that satisfy the core design conditions for employing fuel data from the existing loading pattern of the current operating cycle. The selection of a loading pattern is also related to the cycle plan of an operating nuclear power plant and must meet safety and economic requirements. In selecting an appropriate loading pattern, all aspects, such as input creation, code runs and result processes are processed as text forms manually by a designer, all of which may be subject to human error, such as syntax or running errors. Time-consuming results analysis and decision-making processes are the most significant inefficiencies to avoid. A web-based nuclear plant core design system was developed here to remedy the shortcomings of an existing core design system. The proposed system adopts the general methodology of OPR1000 (Korea Standard Nuclear Power Plants) and Westinghouse-type plants. Additionally, it offers a GUI (Graphic User Interface)-based core design environment with a user-friendly interface for operators. It reduces human errors related to design model creation, computation, final reload core model selection, final output confirmation, and result data validation and verification. Most significantly, it reduces the core design timnificantly, it reduces the core design time by more than 75% compared to its predecessor

  16. Time fractional development of quantum systems

    International Nuclear Information System (INIS)

    In this study, the effect of time fractionalization on the development of quantum systems is taken under consideration by making use of fractional calculus. In this context, a Mittag-Leffler function is introduced as an important mathematical tool in the generalization of the evolution operator. In order to investigate the time fractional evolution of the quantum (nano) systems, time fractional forms of motion are obtained for a Schroedinger equation and a Heisenberg equation. As an application of the concomitant formalism, the wave functions, energy eigenvalues, and probability densities of the potential well and harmonic oscillator are time fractionally obtained via the fractional derivative order ?, which is a measure of the fractality of time. In the case ?=1, where time becomes homogenous and continuous, traditional physical conclusions are recovered. Since energy and time are conjugate to each other, the fractional derivative order ? is relevant to time. It is understood that the fractionalization of time gives rise to energy fluctuations of the quantum (nano) systems.

  17. Development of tritium cleanup system for LHD

    International Nuclear Information System (INIS)

    Energy is vital for humans and we have been consuming a large amount of fossil fuel especially from the beginning of the industrial revolution. Nowadays its huge consumption has however come to threaten our life and we have to prepare nonfossil fuels, for instance solar energy, biomass energy, nuclear energy and so on. Fusion energy is an unlimited resource and one of the strongest candidates of the future energy source. At the National Institute for Fusion Science (referred to as 'NIFS' hereafter), we have constructed a new fusion experimental device called large helical device (referred to as 'LHD' hereafter) in 1998. The device will generate a small amount of tritium, as a fusion product. In order to remove it from the exhaust gas, we have designed a tritium cleanup system based on a new concept. This system is mainly composed of a palladium permeater, a decomposer and hydrogen absorbing alloys. It may perfectly recover the tritium from exhaust gas without oxidizing it. This system is applicable for the future needs at fusion power plants. In order to remove tritium discharged from fusion experimental facilities, it is usual to employ a system by which tritiated constituents, in various chemical forms, are entirely converted to a form of water vapor by catalytic oxidation. The water vapor containing tritiated form is then absorbed by molecular sieve (referred to as 'wet system' hereafter). However, in the case of LHD, it is not rational to deliberately convert the not rational to deliberately convert the discharged tritium into the water vapor, because the tritium discharged from LHD is almost in a form of hydrogen molecules. Moreover, the tritium in the form of water vapor affects the human body 18000 times stronger than that of hydrogen molecules. In accordance with these view points, we have developed another type of tritium cleanup system based on a new concept, in which hydrogen molecules including tritiated ones (HT, DT and T2) found in the exhaust gas of LHD are directly fixed to hydrogen absorbing alloys. Other impurities such as methane and water vapor, parts of which are tritiated, will be decomposed into each elemental form by the decomposition process and hydrogen molecules, including tritiated constituents from the decomposition (referred to as 'dry system' hereafter)

  18. Measurement process of software development projects for supporting strategic business objectives in software developing companies

    Scientific Electronic Library Online (English)

    Sandra Lais, Pedroso; Leonardo Rocha de, Oliveira.

    2013-05-01

    Full Text Available SciELO Brazil | Language: English Abstract in english Software developing companies work in a competitive market and are often challenged to make business decisions with impact on competitiveness. Models accessing maturity for software development processes quality, such as CMMI and MPS-BR, comprise process measurements systems (PMS). However, these mo [...] dels are not necessarily suitable to support business decisions, neither to achieve strategic goals. The objective of this work is to analyze how the PMS of software development projects could support business strategies for software developing companies. Results taken from this work show that PMS results from maturity models for software processes can be suited to help evaluating operating capabilities and supporting strategic business decisions.

  19. Development of Vertical Cable Seismic System (3)

    Science.gov (United States)

    Asakawa, E.; Murakami, F.; Tsukahara, H.; Mizohata, S.; Ishikawa, K.

    2013-12-01

    The VCS (Vertical Cable Seismic) is one of the reflection seismic methods. It uses hydrophone arrays vertically moored from the seafloor to record acoustic waves generated by surface, deep-towed or ocean bottom sources. Analyzing the reflections from the sub-seabed, we could look into the subsurface structure. Because VCS is an efficient high-resolution 3D seismic survey method for a spatially-bounded area, we proposed the method for the hydrothermal deposit survey tool development program that the Ministry of Education, Culture, Sports, Science and Technology (MEXT) started in 2009. We are now developing a VCS system, including not only data acquisition hardware but data processing and analysis technique. We carried out several VCS surveys combining with surface towed source, deep towed source and ocean bottom source. The water depths of the survey are from 100m up to 2100m. The target of the survey includes not only hydrothermal deposit but oil and gas exploration. Through these experiments, our VCS data acquisition system has been completed. But the data processing techniques are still on the way. One of the most critical issues is the positioning in the water. The uncertainty in the positions of the source and of the hydrophones in water degraded the quality of subsurface image. GPS navigation system are available on sea surface, but in case of deep-towed source or ocean bottom source, the accuracy of shot position with SSBL/USBL is not sufficient for the very high-resolution imaging. We have developed another approach to determine the positions in water using the travel time data from the source to VCS hydrophones. In the data acquisition stage, we estimate the position of VCS location with slant ranging method from the sea surface. The deep-towed source or ocean bottom source is estimated by SSBL/USBL. The water velocity profile is measured by XCTD. After the data acquisition, we pick the first break times of the VCS recorded data. The estimated positions of shot points and receiver points in the field include the errors. We use these data as initial guesses, we invert iteratively shot and receiver positions to match the travel time data. After several iterations we could finally estimate the most probable positions. Integration of the constraint of VCS hydrophone positions, such as the spacing is 10m, can accelerate the convergence of the iterative inversion and improve results. The accuracy of the estimated positions from the travel time date is enough for the VCS data processing.

  20. GST Revisited: Working Systems Principles for Training and Development Consultants.

    Science.gov (United States)

    Owens, Elizabeth

    1990-01-01

    Presents seven principles for applying technology to training and development problems. Based on General Systems Theory (GST), these principles were developed to help with long-term decisions. Highlights include instructional systems development models; complexity in cultural systems; matching training materials to user characteristics; systems

  1. Reliable Software Development for Machine Protection Systems

    CERN Document Server

    Anderson, D; Dragu, M; Fuchsberger, K; Garnier, JC; Gorzawski, AA; Koza, M; Krol, K; Misiowiec, K; Stamos, K; Zerlauth, M

    2014-01-01

    The Controls software for the Large Hadron Collider (LHC) at CERN, with more than 150 millions lines of code, resides amongst the largest known code bases in the world1. Industry has been applying Agile software engineering techniques for more than two decades now, and the advantages of these techniques can no longer be ignored to manage the code base for large projects within the accelerator community. Furthermore, CERN is a particular environment due to the high personnel turnover and manpower limitations, where applying Agile processes can improve both, the codebase management as well as its quality. This paper presents the successful application of the Agile software development process Scrum for machine protection systems at CERN, the quality standards and infrastructure introduced together with the Agile process as well as the challenges encountered to adapt it to the CERN environment.

  2. Systems vaccinology for cancer vaccine development.

    Science.gov (United States)

    Petrizzo, Annacarmen; Tagliamonte, Maria; Tornesello, Marialina; Buonaguro, Franco M; Buonaguro, Luigi

    2014-06-01

    Results of therapeutic vaccines for established chronic infections or cancers are still unsatisfactory. The only therapeutic cancer vaccine approved for clinical use is the sipuleucel-T, for the treatment of metastatic prostate cancer, which induces a limited 4-month improvement in the overall survival of vaccinated patients compared to controls. This represents a remarkable advancement in the cancer immunotherapy field, although the clinical outcome of cancer vaccines needs to be substantially improved. To this aim, a multipronged strategy is required, including the evaluation of mechanisms underlying the effective elicitation of immune responses by cancer vaccines. The recent development of new technologies and computational tools allows the comprehensive and quantitative analysis of the interactions between all of the components of innate and adaptive immunity over time. Here we review the potentiality of systems biology in providing novel insights in the mechanisms of action of vaccines to improve their design and effectiveness. PMID:24766452

  3. Development of CRD stub tube welding system

    International Nuclear Information System (INIS)

    The reactor pressure vessel (RPV) of nuclear power plants include control rod drive (CRD) stub tubes installed on the inner surface of the bottom head by welding. Weld seams are located at the root of each stub tube, to which accessibility is limited. The weld travel requires an elliptical movement with inclination along the inner bottom head surface, and furthermore the location on the bottom head of each stub tube has different angle of inclination. CRD stub tubes were installed by skilled welders using MIG welding in previous RPV construction. Recently, a CRD stub tube TIG welding system was developed for RPV construction in the near future, which can be applied to such 3 dimensional welding orbit. (author)

  4. Design and Development of Robot Hand System

    Directory of Open Access Journals (Sweden)

    Panchumarthy Seetharamaiah

    2011-01-01

    Full Text Available Research on robot hand design is being carried out to accommodate a variety of tasks such as grasping and manipulation of objects in the field of industrial applications, service robots and rehabilitation robots. Problem statement: To design and develop a microcontroller-based four fingered robotic hand with a simple and minimal control strategy to pick and place application with object detection by simple IR sensor logic. Approach: The methodology is based on anthropomorphic design with three fingers and an opposing thumb. Each finger has three links and three double revolute joints. Each finger is actuated by a single opposing pair of tendons. The robot hand system is interfaced to microcontroller with software control by means of 14 independent commands for the motion of joints: close and open for fore finger, middle finger, ring finger and thumb finger and wrist up and down, base clockwise and counter clockwise, pick and place and home position. The tendoning system and wireless feedback logic provide the hand with the ability to confirm to object topology and therefore providing the advantage of using a simple control structure. Results: Reliable grasping and releasing is achieved with simple control mechanisms and IR sensors/push-button switches. The hand can pick a variety of objects with different surface characteristics and shapes without having to reconstruct its surface description. Picking of the object is successfully completed as long as the object is within the workspace of the hand and placed the object at the desired position within the workspace by relevant software control using keyboard commands. Conclusion: Hardware and software development of microcontroller-based four-fingered robotic hand is addressed. Details of hand control software for mainly pick and place applications are presented. Results of the experimental work for pick and place application of different objects is enumerated.

  5. Development of portable driving simulator system

    Directory of Open Access Journals (Sweden)

    Y. Itoh

    2008-08-01

    Full Text Available Purpose: In accordance with aging of populations in many developed countries, number of drivers who suffer from mild cognitive impairment (MCI drivers is increasing. Since it has been reported that driving skill of the MCI drivers are deteriorated, it is important to train themselves in driving situation to preserve their driving skills. The present study was conducted to develop the simple driving simulator system, and to examine the effect of training in this system.Design/methodology/approach: Nineteen university students (8 males and 11 females participated in this study. After the habituation period (approximately 5min, three trials (approximately 12 min were conducted. Experimental situation imitated the real highway course. During trials, dangerous situation that would be resulted in car accident is randomly appeared and participants were required to avoid the car accidents. To avoid the possible car accidents are considered as correct response.Findings: Mean percent of correct responses for male and female were 75.2% and 56.6% in 1st trial and 95.7% and 72.6% in 3rd trial, respectively. Two-way analysis of variance revealed that the main effect of sex(F (1, 14 = 7.84, p < .05 and trials (F (2, 34 = 10.19, p < .001. These results indicate that numbers of car accidents are dramatically decreased and the driving skills of male are superior to that of female.Practical implications: Although the present study revealed the differences in driving skills between the sexes, their driving history was not considered. Driving history of each participant should be examined in future study.Originality/value: Since the improvement of driving skills is revealed, our experimental design is expected as the tool for the preservation of driving skills in the MCI drivers.

  6. Developing Higher-Order Materials Knowledge Systems

    Science.gov (United States)

    Fast, Anthony Nathan

    2011-12-01

    Advances in computational materials science and novel characterization techniques have allowed scientists to probe deeply into a diverse range of materials phenomena. These activities are producing enormous amounts of information regarding the roles of various hierarchical material features in the overall performance characteristics displayed by the material. Connecting the hierarchical information over disparate domains is at the crux of multiscale modeling. The inherent challenge of performing multiscale simulations is developing scale bridging relationships to couple material information between well separated length scales. Much progress has been made in the development of homogenization relationships which replace heterogeneous material features with effective homogenous descriptions. These relationships facilitate the flow of information from lower length scales to higher length scales. Meanwhile, most localization relationships that link the information from a from a higher length scale to a lower length scale are plagued by computationally intensive techniques which are not readily integrated into multiscale simulations. The challenge of executing fully coupled multiscale simulations is augmented by the need to incorporate the evolution of the material structure that may occur under conditions such as material processing. To address these challenges with multiscale simulation, a novel framework called the Materials Knowledge System (MKS) has been developed. This methodology efficiently extracts, stores, and recalls microstructure-property-processing localization relationships. This approach is built on the statistical continuum theories developed by Kroner that express the localization of the response field at the microscale using a series of highly complex convolution integrals, which have historically been evaluated analytically. The MKS approach dramatically improves the accuracy of these expressions by calibrating the convolution kernels in these expressions to results from previously validated physics-based models. These novel tools have been validated for the elastic strain localization in moderate contrast dual-phase composites by direct comparisons with predictions from finite element model. The versatility of the approach is further demonstrated by its successful application to capturing the structure evolution during spinodal decomposition of a binary alloy. Lastly, some key features in the future application of the MKS approach are developed using the Portevin-le Chaterlier effect. It has been shown with these case studies that the MKS approach is capable of accurately reproducing the results from physics based models with a drastic reduction in computational requirements.

  7. Development of the excretory system in a polyplacophoran mollusc: stages in metanephridial system development

    Directory of Open Access Journals (Sweden)

    Baeumler Natalie

    2012-09-01

    Full Text Available Abstract Background Two types of excretory systems, protonephridia and metanephridial systems are common among bilaterians. The homology of protonephridia of lophotrochozoan taxa has been widely accepted. In contrast, the homology of metanephridial systems – including coelomic cavities as functional units – among taxa as well as the homology between the two excretory systems is a matter of ongoing discussion. This particularly concerns the molluscan kidneys, which are mostly regarded as being derived convergently to the metanephridia of e.g. annelids because of different ontogenetic origin. A reinvestigation of nephrogenesis in polyplacophorans, which carry many primitive traits within molluscs, could shed light on these questions. Results The metanephridial system of Lepidochitona corrugata develops rapidly in the early juvenile phase. It is formed from a coelomic anlage that soon achieves endothelial organization. The pericardium and heart are formed from the central portion of the anlage. The nephridial components are formed by outgrowth from lateral differentiations of the anlage. Simultaneously with formation of the heart, podocytes appear in the atrial wall of the pericardium. In addition, renopericardial ducts, kidneys and efferent nephroducts, all showing downstream ciliation towards the internal lumen, become differentiated (specimen length: 0.62 mm. Further development consists of elongation of the kidney and reinforcement of filtration and reabsorptive structures. Conclusions During development and in fully formed condition the metanephridial system of Lepidochitona corrugata shares many detailed traits (cellular and overall organization with the protonephridia of the same species. Accordingly, we suggest a serial homology of various cell types and between the two excretory systems and the organs as a whole. The formation of the metanephridial system varies significantly within Mollusca, thus the mode of formation cannot be used as a homology criterion. Because of similarities in overall organization, we conclude that the molluscan metanephridial system is homologous with that of the annelids not only at the cellular but also at the organ level.

  8. Development of shielding design analysis system

    International Nuclear Information System (INIS)

    The aim of this work is to develop insufficient auxiliary routines which manage input and output data and interface the main codes and to establish a shielding design analysis system on work stations (SUN, DEC). In shielding design analyses, one- and two- dimensional (1-D and 2-D) transport Sn codes are used mainly with some auxiliary codes which generate input data of Sn calculation and edit Sn calculation outputs. The main transport calculation codes can be obtained from the Code Center of RIST (Research Organization for Information Science and Technology). In this work, peripheral codes are developed to generate cross sections, produce Sn quadrature sets, edit calculation outputs or draw contour figures. In shielding calculations around a reactor, the boot-strapping technique is often employed to treat a large area extending from the core to the biological shield to improve the calculation accuracy. When a three-dimensional (3-D) calculation for a complex geometry with shielding defects, 2-D and 3-D coupling calculation is employed frequently. To use this coupling method conversion cods are prepared which read flux file from DORT and prepare an external boundary source file for the 2-D or the 3-D calculation codes. For further conveniences well used data such as the Sn quadrature sets, the dose rate conversion factors, the reaction cross section sets are stored as a data base and code manuals including sample inputs of typical problems are prepared which are comprecal problems are prepared which are comprehensible to beginners. (author)

  9. Information System on Occupational Exposure: Future Developments

    International Nuclear Information System (INIS)

    In response to pressures from deregulation and from ageing of the global nuclear power plant fleet, radiation protection personnel have found that occupational exposures are best managed through proper job planning, implementation and review to ensure that exposures are 'as low as reasonably achievable'(ALARA). A prerequisite for applying the principle of optimisation to occupational radiation protection is the timely exchange of data and information on dose reduction methods. To facilitate this global approach to work management, the OECD Nuclear Energy Agency (Nea) launched the Information System on Occupational Exposure (I.S.O.E.) in 1992. The objective of I.S.O.E. is to provide a forum for radiation protection experts from both utilities and national regulatory authorities to discuss, promote and coordinate international cooperative undertakings for the radiological protection of workers at nuclear power plants.The I.S.O.E. programme offers a variety of products in the occupational exposure area, such as: the world largest database on occupational exposure from nuclear power plants, a yearly analysis of dose trends and an overview of current developments, through I.S.O.E. Annual Reports, detailed studies, analyses, and information on current issues in operational radiation protection, through I.S.O.E. Information Sheets, a system for rapid communication of radiation protection-related information, such as effective dose reduction approaches and implementation of work management principles. A forum for discussing occupational exposure management issues through I.S.O.E. workshops, symposia and newsletters. (N.C.)

  10. Systems approach to nuclear waste glass development

    International Nuclear Information System (INIS)

    Development of a host solid for the immobilization of nuclear waste has focused on various vitreous wasteforms. The systems approach requires that parameters affecting product performance and processing be considered simultaneously. Application of the systems approach indicates that borosilicate glasses are, overall, the most suitable glasses for the immobilization of nuclear waste. Phosphate glasses are highly durable; but the glass melts are highly corrosive and the glasses have poor thermal stability and low solubility for many waste components. High-silica glasses have good chemical durability, thermal stability, and mechanical stability, but the associated high melting temperatures increase volatilization of hazardous species in the waste. Borosilicate glasses are chemically durable and are stable both thermally and mechanically. The borosilicate melts are generally less corrosive than commercial glasses, and the melt temperature miimizes excessive volatility of hazardous species. Optimization of borosilicate waste glass formulations has led to their acceptance as the reference nuclear wasteform in the United States, United Kingdom, Belgium, Germany, France, Sweden, Switzerland, and Japan

  11. Microelectromechanical Systems (MEMS) Broadband Light Source Developed

    Science.gov (United States)

    Tuma, Margaret L.

    2003-01-01

    A miniature, low-power broadband light source has been developed for aerospace applications, including calibrating spectrometers and powering miniature optical sensors. The initial motivation for this research was based on flight tests of a Fabry-Perot fiberoptic temperature sensor system used to detect aircraft engine exhaust gas temperature. Although the feasibility of the sensor system was proven, the commercial light source optically powering the device was identified as a critical component requiring improvement. Problems with the light source included a long stabilization time (approximately 1 hr), a large amount of heat generation, and a large input electrical power (6.5 W). Thus, we developed a new light source to enable the use of broadband optical sensors in aerospace applications. Semiconductor chip-based light sources, such as lasers and light-emitting diodes, have a relatively narrow range of emission wavelengths in comparison to incandescent sources. Incandescent light sources emit broadband radiation from visible to infrared wavelengths; the intensity at each wavelength is determined by the filament temperature and the materials chosen for the filament and the lamp window. However, present commercial incandescent light sources are large in size and inefficient, requiring several watts of electrical power to obtain the desired optical power, and they emit a large percentage of the input power as heat that must be dissipated. The miniature light source, developed jointly by the NASA Glenn Research Center, the Jet Propulsion Laboratory, and the Lighting Innovations Institute, requires one-fifth the electrical input power of some commercial light sources, while providing similar output light power that is easily coupled to an optical fiber. Furthermore, it is small, rugged, and lightweight. Microfabrication technology was used to reduce the size, weight, power consumption, and potential cost-parameters critical to future aerospace applications. This chip-based light source has the potential for monolithic fabrication with on-chip drive electronics. Other uses for these light sources are in systems for vehicle navigation, remote sensing applications such as monitoring bridges for stress, calibration sources for spectrometers, light sources for space sensors, display lighting, addressable arrays, and industrial plant monitoring. Two methods for filament fabrication are being developed: wet-chemical etching and laser ablation. Both yield a 25-mm-thick tungsten spiral filament. The proof-of-concept filament shown was fabricated with the wet etch method. Then it was tested by heating it in a vacuum chamber using about 1.25 W of electrical power; it generated bright, blackbody radiation at approximately 2650 K. The filament was packaged in Glenn's clean-room facilities. This design uses three chips vacuum-sealed with glass tape. The bottom chip consists of a reflective film deposited on silicon, the middle chip contains a tungsten filament bonded to silicon, and the top layer is a transparent window. Lifetime testing on the package will begin shortly. The emitted optical power is expected to be approximately 1.0 W with the spectral peak at 1.1 mm.

  12. Centromere-tethered Mps1 pombe homolog (Mph1) kinase is a sufficient marker for recruitment of the spindle checkpoint protein Bub1, but not Mad1

    OpenAIRE

    Ito, Daisuke; Saito, Yu; Matsumoto, Tomohiro

    2011-01-01

    The spindle checkpoint delays the onset of anaphase until all of the chromosomes properly achieve bipolar attachment to the spindle. It has been shown that unattached kinetochores are the site that emits a signal for activation of the checkpoint. Although the components of the checkpoint such as Bub1, Mad1 and Mad2 selectively accumulate at unattached kinetochores, the answer to how they recognize unattached kinetochores has remained elusive. Mps1 pombe homolog (Mph1) kinase has been shown to...

  13. Development and demonstration of advanced power generation systems at the Power Systems Development Facility

    Energy Technology Data Exchange (ETDEWEB)

    Longanbach, J.R.; Pinkston, T.E.

    2000-07-01

    Testing and development of new components and advanced systems under long-term, realistic integrated process conditions is critical to the future commercialization of cleaner, more efficient, fossil fuel-fired power generation. The Power Systems Development Facility (PSDF) is a joint Industry/DOE large scale pilot/demonstration plant operated by Southern Company Services near Wilsonville, Alabama, about 25 miles southeast of Birmingham. The objective of the PSDF project is to test and gain operating experience with new process configurations and critical components for advanced fossil fuel-based power generation systems at a scale large enough to provide data for scaleup to demonstration or first commercial plants. Southern Company Services, Inc. is leading a team of equipment and process developers which is currently starting up and/or operating the PSDF technologies. The ability of advanced Particulate Control Devices (PCDs) to clean hot gas is critical since they are necessary for the advanced process configurations and more developmental effort is needed to improve their design and reliability under typical gasification and combustion operating conditions. In addition, it is necessary to demonstrate reliable operation of many off-the-shelf equipment components and systems under the conditions of advanced power generation processes to reduce the risk of these new systems to levels where financing can be arranged for demonstration and early commercial plants. Several technologies have been located at the PSDF to save on the costs of balance-of-plant utilities and other infrastructure.

  14. Phosphoregulation of Spc105 by Mps1 and PP1 Regulates Bub1 Localization to Kinetochores

    OpenAIRE

    London, Nitobe; Ceto, Steven; Ranish, Jeffrey A.; Biggins, Sue

    2012-01-01

    Kinetochores are the macromolecular complexes that interact with microtubules to mediate chromosome segregation [1]. Accurate segregation requires that kinetochores make bioriented attachments to microtubules from opposite poles. Attachments between kinetochores and microtubules are monitored by the spindle checkpoint, a surveillance system that prevents anaphase until every pair of chromosomes makes proper bioriented attachments [2]. Checkpoint activity is correlated with the recruitment of ...

  15. Controlling Complex Systems and Developing Dynamic Technology

    Science.gov (United States)

    Avizienis, Audrius Victor

    In complex systems, control and understanding become intertwined. Following Ilya Prigogine, we define complex systems as having control parameters which mediate transitions between distinct modes of dynamical behavior. From this perspective, determining the nature of control parameters and demonstrating the associated dynamical phase transitions are practically equivalent and fundamental to engaging with complexity. In the first part of this work, a control parameter is determined for a non-equilibrium electrochemical system by studying a transition in the morphology of structures produced by an electroless deposition reaction. Specifically, changing the size of copper posts used as the substrate for growing metallic silver structures by the reduction of Ag+ from solution under diffusion-limited reaction conditions causes a dynamical phase transition in the crystal growth process. For Cu posts with edge lengths on the order of one micron, local forces promoting anisotropic growth predominate, and the reaction produces interconnected networks of Ag nanowires. As the post size is increased above 10 microns, the local interfacial growth reaction dynamics couple with the macroscopic diffusion field, leading to spatially propagating instabilities in the electrochemical potential which induce periodic branching during crystal growth, producing dendritic deposits. This result is interesting both as an example of control and understanding in a complex system, and as a useful combination of top-down lithography with bottom-up electrochemical self-assembly. The second part of this work focuses on the technological development of devices fabricated using this non-equilibrium electrochemical process, towards a goal of integrating a complex network as a dynamic functional component in a neuromorphic computing device. Self-assembled networks of silver nanowires were reacted with sulfur to produce interfacial "atomic switches": silver-silver sulfide junctions, which exhibit complex dynamics (e.g. both short- and long-term changes in conductivity) in response to applied voltage signals. Characterization of these atomic switch networks (ASNs) brought out interesting parallels to biological neural networks, including power-law scaling in the statistics of electrical signal propagation and dynamic self-organization of differentiated subnetworks. A reservoir computing (RC) strategy was employed to utilize measurements of electrical signals dynamically generated in ASNs to perform time-series memory and manipulation tasks including a parity test and arbitrary waveform generation. These results represent the useful integration of a complex network into a dynamic physical RC device.

  16. Numerical simulation of multi-phase flow in sodium-water reaction using MPS method. Numerical investigation of droplet breakup and flow regime

    International Nuclear Information System (INIS)

    Tube rupture accidents in steam generators of sodium-cooled fast breeder reactors are important for safety because the rupture may propagates to neighboring tubes due to sodium-water reaction. In order to clarify the thermal-hydraulic phenomena in the accidents, the flow pattern and the interface in multi-phase flow must be investigated. The JNC cooperative research scheme on the nuclear fuel cycle with The University of Tokyo has been carried out to investigate a flow regime and interfacial area density of multi-phase flow in sodium-water reaction using the Moving-Particle Semi-implicit (MPS) method. Since grids are not necessary in the MPS methods, it is not difficult to analyze separation and merging of fluids. In the tube rupture accidents in steam generators, high-pressure and high-temperature water is discharged into low-pressure sodium. Discharged water is disintegrated from a jet to droplets and further disintegrated to smaller droplets (droplet breakup). Thus, the MPS method is fitted to these phenomena. The following conclusions were obtained in this research. Numerical analysis of the droplet breakup process was carried out. Breakup mechanisms was clarified and the critical Weber number was obtained. Water flashing was modeled for the particle method and numerical simulation of water discharge into sodium was analyzed. The interfacial area was evaluated based on the above results. (author)

  17. Business Process Modeling for developing Process Oriented IT Systems

    OpenAIRE

    Nurcan, Selmin

    2004-01-01

    Information system developers are challenged to develop systems that should meet the requirements of modern organizations. By promoting the enterprise-wide integration, the paradigm of Business Process Management contrasts with traditional information system development, which was suffered, but also crystallized, the vertical division of the enterprise activities. In addition, the paradigms of Business Process Reengineering and Business Process Improvement contrast with traditional informatio...

  18. Development of Traction Drive Motors for the Toyota Hybrid System

    Science.gov (United States)

    Kamiya, Munehiro

    Toyota Motor Corporation developed in 2005 a new hybrid system for a large SUV. This system included the new development of a high-speed traction drive motor achieving a significant increase in power weight ratio. This paper provides an overview of the hybrid system, discusses the characteristics required of a traction drive motor, and presents the technologies employed in the developed motor.

  19. Development of white LED based PV lighting systems

    Energy Technology Data Exchange (ETDEWEB)

    Sastry, O.S.; Pant, P.C.; Prasad, G.; Kumar, Rajesh; Bandyopadhyay, Bibek [Solar Energy Centre, Ministry of New and Renewable Energy, Block 14, CGO Complex, Lodhi Road, New Delhi 110003 (India); Kamala Devi, V. [Agency for Non-Conventional Energy and Rural Technology, P.B. No. 1094, Pattom, P.O. Kasavadasapuram, Trivandrum, Kerala 695 004 (India)

    2010-09-15

    A high performance white light emitting diode (WLED) based PV lighting system has been developed under a joint project of SEC and ANERT. The system has been analyzed using the test set-ups developed as a part of advanced lighting laboratory (ALL). The results show that the performance is one of the best among the systems developed in the capacity range. (author)

  20. Development of oxide fibrous monolith systems.

    Energy Technology Data Exchange (ETDEWEB)

    Goretta, K. C.

    1999-03-02

    Fibrous monolithic ceramics generally have a cellular structure that consists of a strong cell surrounded by a weaker boundary phase [1-5]. Fibrous monoliths (FMs) are produced from powders by conventional ceramic fabrication techniques, such as extrusion [1,2]. When properly engineered, they exhibit fail gracefully [3-5]. Several compositions of ceramics and cermets have been processed successfully in fibrous monolithic form [4]. The most thoroughly investigated fibrous monolith consists of Si{sub 3}N{sub 4} cells and a BN cell-boundary phase [3-5]. Through appropriate selection of initial powders and extrusion and hot-pressing parameters, very tough final products have been produced. The resultant high toughness is due primarily to delamination during fracture along textured platelike BN grains. The primary objectives of our program are to develop: (1) Oxide-based FMs, including new systems with improved properties; (2) FMs that can be pressureless sintered rather than hot-pressed; (3) Techniques for continuous extrusion of FM filaments, including solid freeform fabrication (SFF) for net-shape fabrication of FMs; (4) Predictive micromechanical models for FM design and performance; and (5) Ties with industrial producers and users of FMs.

  1. Development of a system of programs HAMMER - ORIGEN - 2 system

    International Nuclear Information System (INIS)

    The development of a system of programs (Hamor-2) to calculate precision inventory of LWR reactors is presented. The Hamor-2 code generates with the Hammer-technion code the four (4) energy groupe effective cross section of the actinides: U-235, U-236, U-238, Pu-239, Pu-240, Pu-241, Pu-242. Hamor-2 collapses the four group energy effective cross section to one group energy effective cross section. Hamor-2 calculates with origen-2 the new concentrations for the actinides using the one group energy effective cross section. Two PWR reactors were analised. (HBR, KWO). The discrepancy between the final actinides conentration results calculated by Hamor-2 and the results of measures finded in the references were calculated. That discrepancies have been compared with the discrepancy between : the final actinide concentration results calculated by Origen-2 and some measured results finded in the references. (E.G.)

  2. Integrated System Health Management Development Toolkit

    Science.gov (United States)

    Figueroa, Jorge; Smith, Harvey; Morris, Jon

    2009-01-01

    This software toolkit is designed to model complex systems for the implementation of embedded Integrated System Health Management (ISHM) capability, which focuses on determining the condition (health) of every element in a complex system (detect anomalies, diagnose causes, and predict future anomalies), and to provide data, information, and knowledge (DIaK) to control systems for safe and effective operation.

  3. Development of photovoltaic systems with concentration

    OpenAIRE

    Reis, Filipa

    2013-01-01

    The concept of Concentration Photovoltaic (CPV) systems appeared as an attempt to reduce the cost of Photovoltaic (PV) technology. In these systems, savings are achieved by the reduction of the area of the expensive PV cell which is compensated by the increase in the light intensity on the device through less expensive optical elements. This thesis focus on two main CPV systems: i) the DoubleSun® technology, a low CPV system, already commercialized; and ii) a new medium CPV system, the HSun ...

  4. The development of KAERI management information system -First year: The development of manpower information management system-

    International Nuclear Information System (INIS)

    The purpose of this report is to describe the implementation of the management information system for manpower. This job is the first year's for development KAERI management information system. It is important to properly manage a manpower to cope with the external circumstances promptly and to maximize the productivity of the organization. This report aims at basic management of manpower and uses multimedia to keep abreast with the times and introduces the concept of GUI (Graphic User Interface) to user for ease access. (Author)

  5. Diagnostics Systems for Permanent Hall Thrusters Development

    Science.gov (United States)

    Ferreira, Jose Leonardo; Soares Ferreira, Ivan; Santos, Jean; Miranda, Rodrigo; Possa, M. Gabriela

    This work describes the development of Permanent Magnet Hall Effect Plasma Thruster (PHALL) and its diagnostic systems at The Plasma Physics Laboratory of University of Brasilia. The project consists on the construction and characterization of plasma propulsion engines based on the Hall Effect. Electric thrusters have been employed in over 220 successful space missions. Two types stand out: the Hall-Effect Thruster (HET) and the Gridded Ion Engine (GIE). The first, which we deal with in this project, has the advantage of greater simplicity of operation, a smaller weight for the propulsion subsystem and a longer shelf life. It can operate in two configurations: magnetic layer and anode layer, the difference between the two lying in the positioning of the anode inside the plasma channel. A Hall-Effect Thruster-HET is a type of plasma thruster in which the propellant gas is ionized and accelerated by a magneto hydrodynamic effect combined with electrostatic ion acceleration. So the essential operating principle of the HET is that it uses a J x B force and an electrostatic potential to accelerate ions up to high speeds. In a HET, the attractive negative charge is provided by electrons at the open end of the Thruster instead of a grid, as in the case of the electrostatic ion thrusters. A strong radial magnetic field is used to hold the electrons in place, with the combination of the magnetic field and the electrostatic potential force generating a fast circulating electron current, the Hall current, around the axis of the Thruster, mainly composed by drifting electrons in an ion plasma background. Only a slow axial drift towards the anode occurs. The main attractive features of the Hall-Effect Thruster are its simple design and operating principles. Most of the Hall-Effect Thrusters use electromagnet coils to produce the main magnetic field responsible for plasma generation and acceleration. In this paper we present a different new concept, a Permanent Magnet Hall-Effect Thruster (PMHET), developed at the Plasma Physics Laboratory of UnB. The idea of using an array of permanent magnets, instead of an electromagnet, to produce a radial magnetic field inside the cylindrical plasma drift channel of the thruster is very attractive, especially because of the possibility of developing a HET with power consumption low enough to be used in small satellites or medium-size satellites with low on board power. Hall-Effect Thrusters are now a very good option for spacecraft primary propulsion and also for station-keeping of medium and large satellites. This is because of their high specific impulse, efficient use of propellant mass and combined low and precise thrust capabilities, which are related to an economy in terms of propellant mass utilization , longer satellite lifetime and easier spacecraft maneuvering in microgravity environment. The first HETs were developed in the mid 1950’s, and they were first called Closed Drift Thrusters. Today, the successful use of electric thrusters for attitude control and orbit modification on hundreds of satellites shows the advanced stage of development of this technology. In addition to this, after the success of space missions such as Deep Space One and Dawn (NASA), Hayabusa (JAXA) and Smart-1 (ESA), the employment of electric thrusters is also consolidated for the primary propulsion of spacecraft. This success is mainly due to three factors: reliability of this technology; efficiency of propellant utilization, and therefore reduction of the initial mass of the ship; possibility of operation over long time intervals, with practically unlimited cycling and restarts. This thrusting system is designed to be used in satellite attitude control and long term space missions. One of the greatest advantage of this kind of thruster is the production of a steady state magnetic field by permanent magnets providing electron trapping and Hall current generation within a significant decrease on the electric energy supply and thus turning this thruster into a specially good option when it comes to space usage

  6. Extended professional development for systemic curriculum reform

    Science.gov (United States)

    Kubitskey, Mary Elizabeth

    Education standards call for adopting inquiry science instruction. Successful adoption requires professional development (PD) to support teachers, increasing the need for research on PD. This dissertation examines the question: What is the influence of high quality, curriculum aligned, long-term group workshops and related practice on teacher learning? I focus on the following subquestions: (1) What is the influence of high quality, curriculum aligned, long-term, group workshops on teacher knowledge and beliefs? (2) What is the impact of the workshops on teacher practice? (3) What is the influence of practice on student response? (4) What is the impact of practice and student response on teacher knowledge and beliefs? I focus on an instance of PD nested within a long-term systemic change initiative, tracing eleven science teachers' learning from workshops and associated enactments. The data included pre and post-unit interviews (n=22), two post-workshop interviews (n=17), workshop observations (n=2), classroom observations (n=24) and student work (n=351). I used mixed-methods analysis. Quantitative analysis measured teacher learning by comparing pre and post-unit interview ratings. Qualitative components included two case study approaches: logic model technique and cross-case synthesis, examining teacher learning within and across teachers. The findings suggested a teacher-learning model incorporating PD, teacher knowledge, beliefs, practice and student response. PD impacts teachers' knowledge by providing teachers with new knowledge, adapting previous knowledge, or convincing them to value existing knowledge they chose not to use. The workshops can influence beliefs, providing teachers with confidence and motivation to adopt the practice. Beliefs can mediate how knowledge manifested itself in practice that, in turn, impacts students' response. Student response influences the teachers' beliefs, either reinforcing or motivating change. This teacher-learning model suggests a PD design model for long-term systemic change, incorporating teacher practice and student response, providing guidance for teachers making adaptations that maintain reform. This dissertation responds to the call for empirical research linking PD to learning outcomes. These models are unique because practice becomes a continuum of PD, rather than outcome and stresses the importance of addressing teachers' beliefs. This PD design provides mechanisms for maintaining equivalence between the written and enacted curriculum, sustaining the integrity of the reform.

  7. MPS solidification model. Analysis and calculation of macrosegregation in a casting ingot

    Science.gov (United States)

    Poirier, D. R.; Maples, A. L.

    1985-01-01

    Work performed on several existing solidification models for which computer codes and documentation were developed is presented. The models describe the solidification of alloys in which there is a time varying zone of coexisting solid and liquid phases; i.e., the S/L zone. The primary purpose of the models is to calculate macrosegregation in a casting or ingot which results from flow of interdendritic liquid in this S/L zone during solidification. The flow, driven by solidification contractions and by gravity acting on density gradients in the interdendritic liquid, is modeled as flow through a porous medium. In Model 1, the steady state model, the heat flow characteristics are those of steady state solidification; i.e., the S/L zone is of constant width and it moves at a constant velocity relative to the mold. In Model 2, the unsteady state model, the width and rate of movement of the S/L zone are allowed to vary with time as it moves through the ingot. Each of these models exists in two versions. Models 1 and 2 are applicable to binary alloys; models 1M and 2M are applicable to multicomponent alloys.

  8. Cultural Development through Human Resource Systems Integration.

    Science.gov (United States)

    Albert, Michael

    1985-01-01

    Discusses the framework for developing a cultural human resources management (HRM) perspective. Central to this framework is modifying HRM programs to reinforce the organization's preferred practices. Modification occurs through selection, orientation, training and development, performance appraisal, career development, and compensation and…

  9. Integrated approach to optomechanical system development

    Science.gov (United States)

    Reney, Thomas E.; Wiggins, Richard L.; Comstock, Lovell E.; Santman, Jeffry J.; Woodard, Kenneth S.

    2011-06-01

    Over the past few decades of computer aided engineering growth there has been much more progress in increasing the power and capability of function specific engineering tools (e.g., optical design, finite element analysis, etc.) than in the integration of and communication between these tools. With only a few notable exceptions, such as FEA being imbedded into solid modeling, the communication method between the function specific tools continues to be dominated by translation to neutral data formats (e.g., IGES, STEP) and file transfer. There are a number of problems with this approach. The translation is a serial process where an engineer has to stop at some point in the design, make the neutral file, send that file to the next function, and wait for feedback. The translation through a neutral format is typically one way so the whole translation process has to be repeated when changes are required. Revision tracking of multiple files for each design iteration is both critical and a likely source of errors. Also, as with any translation, some information is always lost or corrupted in the process. This paper describes some progress that has been made in more tightly integrating optical design, mechanical design, fabrication, and testing of optical systems. Tools have been developed that connect CODE V®[1] to SolidWorks®[2] (bidirectional), compensation of diamond turning CNC from interferometric data, slope analysis from interferometer and profilometer data, and other tools for wavefront error compensation, and electronic nulls. Design, machining, testing and inspection efficiency gains are achieved through tools that consume mechanical solid models in their native format.

  10. Development of a PSA information management system

    International Nuclear Information System (INIS)

    In general, Probabilistic Safety Agreement (PSA) is a very complicated work that uses and generates a lot of resources such as reports, procedures, drawings, assumptions, calculation sheets, PSA model, and so on. In many PSAs, however, the data, materials and knowledge considered and generated during performing PSA are scattered in many documents so that overall structure of PSA and information relationship between documents and models cannot easily be understood. To organize and manage all documents related to PSA, to capture knowledge of analysts, and finally to improve the quality of PSA, a PSA information management system (PIMS) was developed. The PIMS can manage all the documents of a PSA in a database and connect the causal relation between one information to another in the scattered documents via link. The PIMS can manage all the assumptions and technical basis used in PSA, and it can keep the record of the design changes the revision of PSA model. It can also control the review results of PSA models. The link of the PIMS can explicitly describe and reveal the expertise of the PSA analysts, and it enables the users to capture the knowledge and to understand the structure and contents of a PSA with ease. We are planning to apply the PIMS to the PSA of Shin Kori Units 1 and 2 as feasibility study and then to all the PSAs of the nuclear power plants in Korea. The PIMS is expected to contribute to enhancing the quality and confidence of PSA and reducing the effort confidence of PSA and reducing the efforts and costs of maintenance and update of PSA. (authors)

  11. Development of a PSA information management system

    Energy Technology Data Exchange (ETDEWEB)

    Ho, Seok; Dong Kyu, Kim; Sun Koo, Kang [Korea Power Engineering Company, Inc (Korea, Republic of)

    2007-07-01

    In general, Probabilistic Safety Agreement (PSA) is a very complicated work that uses and generates a lot of resources such as reports, procedures, drawings, assumptions, calculation sheets, PSA model, and so on. In many PSAs, however, the data, materials and knowledge considered and generated during performing PSA are scattered in many documents so that overall structure of PSA and information relationship between documents and models cannot easily be understood. To organize and manage all documents related to PSA, to capture knowledge of analysts, and finally to improve the quality of PSA, a PSA information management system (PIMS) was developed. The PIMS can manage all the documents of a PSA in a database and connect the causal relation between one information to another in the scattered documents via link. The PIMS can manage all the assumptions and technical basis used in PSA, and it can keep the record of the design changes the revision of PSA model. It can also control the review results of PSA models. The link of the PIMS can explicitly describe and reveal the expertise of the PSA analysts, and it enables the users to capture the knowledge and to understand the structure and contents of a PSA with ease. We are planning to apply the PIMS to the PSA of Shin Kori Units 1 and 2 as feasibility study and then to all the PSAs of the nuclear power plants in Korea. The PIMS is expected to contribute to enhancing the quality and confidence of PSA and reducing the efforts and costs of maintenance and update of PSA. (authors)

  12. Development of Testing Environment for Embedded Systems

    OpenAIRE

    Miss Ashwini M Motghare, Prof Swapnili P. Karmore

    2012-01-01

    Quality is the life of embedded systems, and thetesting is a basic guarantee for stable and reliable operation ofthe embedded systems. Testing is an important part in thedevelopment of any system as it represents the ultimateverification and validation of specification, design and code.The goal of testing is to design a series of test cases that has thehighest likelihood of finding most of the errors with a minimumamount of time and effort. The techniques used to test theembedded systems prov...

  13. Optimization of space system development resources

    Science.gov (United States)

    Kosmann, William J.; Sarkani, Shahram; Mazzuchi, Thomas

    2013-06-01

    NASA has had a decades-long problem with cost growth during the development of space science missions. Numerous agency-sponsored studies have produced average mission level cost growths ranging from 23% to 77%. A new study of 26 historical NASA Science instrument set developments using expert judgment to reallocate key development resources has an average cost growth of 73.77%. Twice in history, a barter-based mechanism has been used to reallocate key development resources during instrument development. The mean instrument set development cost growth was -1.55%. Performing a bivariate inference on the means of these two distributions, there is statistical evidence to support the claim that using a barter-based mechanism to reallocate key instrument development resources will result in a lower expected cost growth than using the expert judgment approach. Agent-based discrete event simulation is the natural way to model a trade environment. A NetLogo agent-based barter-based simulation of science instrument development was created. The agent-based model was validated against the Cassini historical example, as the starting and ending instrument development conditions are available. The resulting validated agent-based barter-based science instrument resource reallocation simulation was used to perform 300 instrument development simulations, using barter to reallocate development resources. The mean cost growth was -3.365%. A bivariate inference on the means was performed to determine that additional significant statistical evidence exists to support a claim that using barter-based resource reallocation will result in lower expected cost growth, with respect to the historical expert judgment approach. Barter-based key development resource reallocation should work on spacecraft development as well as it has worked on instrument development. A new study of 28 historical NASA science spacecraft developments has an average cost growth of 46.04%. As barter-based key development resource reallocation has never been tried in a spacecraft development, no historical results exist, and a simulation of using that approach must be developed. The instrument development simulation should be modified to account for spacecraft development market participant differences. The resulting agent-based barter-based spacecraft resource reallocation simulation would then be used to determine if significant statistical evidence exists to prove a claim that using barter-based resource reallocation will result in lower expected cost growth.

  14. Development of Decision support System Using Management Information System and Geographic Information System

    OpenAIRE

    Teerawong Laosuwan; Pormate Chunpang; Nutcha Laosuwan

    2013-01-01

    The objective of this study is to develop of decision support system using management information system and geographic information system, a case study in the Faculty of Science Mahasarakham University. This system was created by Open Source Software (OSS) and web GIS solution i.e. University of Minnesota Map Server (UMN Map Server), Appserv software, Quantum GIS, PHP, and Edit Plus etc. The UMN Map Server program will process spatial data from vector and raster, and then illustrate the resu...

  15. Development of a system for safety indicators

    International Nuclear Information System (INIS)

    This R and D effort was carried out to support the introduction of safety performance indicators (SPIs) for the SKI inspections. The main goal was to compile and evaluate indicators currently in use by the Swedish utilities, and those proposed by the SKI. The main parts of the work performed were: - a compilation of safety performance indicators used by the utilities and those proposed by the SKI; - an assessment of selected important attributes for each SPI; - a description of the data collection processes; - an evaluation of how the currently used SPIs cover the various focus areas of the SKI yearly safety performance assessments for the plants; - a proposal of which SPIs to use for the 2002 assessments; - participation in reference group meetings. The utilities have used SPIs since the early 1990s. SPIs are regularly calculated and presented at plants and at corporate offices, and the SPIs are today an integrated part of the management systems. The selection of SPIs is based both on the WANO SPIs and on SPIs defined by the users themselves. The compilation shows that the utilities currently use well over 20 SPIs for follow-up of safety at the plants, including all of the 8 WANO SPIs. A SKI pilot project has proposed a number of SPIs for internal use. The basis is the reporting requirements according to regulations in SKIFS 1998:1, with its barrier- and defence-in-depth principles. A first implementation is planned for the 2002 safety assessments of plant performance. The SKI has in the report proposed use of 9 groups of SPIs. Several are identical or similar to those used by the utilities. An analysis of the data extracted from the SKI LER database STAGBAS implies some quality assurance problems i.e. data are not easily re-created. The data base itself though should be well fit for the application. Users within the Vattenfall group perform various aggregations of the SPIs, while others so far have only presented indicator data for the individual SPIs. Several of the defence-in-depth focus areas of the SKI are covered by many of the indicators, while barrier functions are covered only by a few. Some of the from a reactor safety perspective more remote areas are not reflected at all by the currently used SPIs Conclusions: - Many of the SPIs currently used by the utilities (i.e. the WANO SPIs) are well defined and proven; - Some SPIs, including those proposed by the SKI, are not that well defined and would thereby be less objective in nature; - When using aggregation of SPIs it is important to still keep the transparency in the presentation. Target groups and purposes with the aggregation need to be well defined; - It is not possible to reflect all focus areas of the SKI by the indicator sets currently used. Recommendations: - For use of SPIs to assess performance during 2002 the SKI should stick with those that are well defined and proven, primarily the WANO SPIs, secondarily others used within the utilities. Identification of trends should be possible for such SPIs; - Use of aggregated indicators and defined 'thresholds' is premature. Further development work is needed here; - For many of the SPIs proposed by the SKI, and for some of those used by the utilities more detailed definitions need to be developed, and quality assurance be improved prior to regulatory use; - The assessment of each of the SPIs could be used to take out some of the SPIs due to low safety relevance or low event frequency

  16. Development of living body information monitoring system

    Science.gov (United States)

    Sakamoto, Hidetoshi; Ohbuchi, Yoshifumi; Torigoe, Ippei; Miyagawa, Hidekazu; Murayama, Nobuki; Hayashida, Yuki; Igasaki, Tomohiko

    2010-03-01

    The easy monitoring systems of contact and non-contact living body information for preventing the the Sudden Infant Death Syndrome (SIDS) were proposed as an alternative monitoring system of the infant's vital information. As for the contact monitoring system, respiration sensor, ECG electrodes, thermistor and IC signal processor were integrated into babies' nappy holder. This contact-monitoring unit has RF transmission function and the obtained data are analyzed in real time by PC. In non-contact mortaring system, the infrared thermo camera was used. The surrounding of the infant's mouth and nose is monitored and the respiration rate is obtained by thermal image processing of its temperature change image of expired air. This proposed system of in-sleep infant's vital information monitoring system and unit are very effective as not only infant's condition monitoring but also nursing person's one.

  17. Developing a Small Business Regulatory System

    Directory of Open Access Journals (Sweden)

    Geoff Miller

    2014-09-01

    Full Text Available IntroductionThank you for inviting me to share my thoughts on what the government is doing to reduce the burden on small business. I also look forward to hearing the other speakers talk about how to make the regulatory system more responsive and relevant to business needs.It is more than a year since the fall of Lehman Brothers and the beginning of the Australian Government’s response to the global financial crisis.Today, the Australian economy is showing encouraging signs of recovery. The Government’s policy responses have been largely responsible for placing Australia in a better position than most countries around the world.The Mid-Year Economic and Fiscal Outlook (MYEFO (released earlier this month showed that the economy is performing much better than was forecast in the last Budget — MYEFO shows that Australia is the only advanced economy to have recorded positive growth through the year to June 2009. MYEFO also upgraded the growth forecasts for the following two years with consequental falls in the expected peak unemployment rate.Although this is good news, the GFC has clearly affected, and is continuing to impact on, small business.A number of Australian Chamber of Commerce and Industry surveys have reported large falls in small business confidence and conditions throughout 2008 and early 2009. However, the August ACCI Small Business Survey reports that, while conditions for small business are expected to remain challenging, conditions are stabilising.This good news is supported by the most recent Commonwealth Bank – ACCI Business Expectations Survey, which shows that small, medium and large businesses are expecting business conditions to improve significantly during this quarter.It is true that small businesses succeed or fail on the creativity, ingenuity, innovation and imagination of their owners and staff. It is also true that small businesses are notoriously time poor. When considering ways to improve the regulatory framework for small businesses it is important to weigh up the desire to minimise time spent by businesses on compliance, with maintaining the integrity of the market as a whole.People in my position rely on people like you with the specific knowledge and expertise in small business matters to make sure that reforms are developed which benefit both the small business sector and the wider economy.

  18. Optimization of System Maturity and Equivalent System Mass for Exploration Systems Development Planning

    Science.gov (United States)

    Magnaye, Romulo; Tan, Weiping; Ramirez-Marquez, Jose; Sauser, Bruce

    2010-01-01

    The Exploration Systems Mission Directorate of the National Aeronautics and Space Administration (NASA) is currently pursuing the development of the next generation of human spacecraft and exploration systems throughout the Constellation Program. This includes, among others, habitation technologies for supporting lunar and Mars exploration. The key to these systems is the Exploration Life Support (ELS) system that composes several technology development projects related to atmosphere revitalization, water recovery, waste management and habitation. The proper functioning of these technologies is meant to produce sufficient and balanced resources of water, air, and food to maintain a safe and comfortable environment for long-term human habitation and exploration of space.

  19. Systems considerations for cryogenic thermal switch development

    International Nuclear Information System (INIS)

    One approach for increasing the reliability of cryogenic cooling systems using mechanical cryocoolers is to connect several cryocoolers in parallel using thermal switches to isolate failed or standby machines. In this paper, simplified analytical thermal models are used to investigate thermal switch performance requirements and evaluate the effect of thermal switches on system efficiency. Results show that switch characteristics such as switching ratio and thermal resistance determine cryocooler performance requirements. In order to minimize system input power requirements switch characteristics must be carefully matched to the configuration of the cryocooler system

  20. Development and Utilization of Space Fission Power Systems

    Science.gov (United States)

    Houts, Michael G.; Mason, Lee S.; Palac, Donald T.; Harlow, Scott E.

    2009-01-01

    Space fission power systems could enable advanced civilian space missions. Terrestrially, thousands of fission systems have been operated since 1942. In addition, the US flew a space fission system in 1965, and the former Soviet Union flew 33 such systems prior to the end of the Cold War. Modern design and development practices, coupled with 65 years of experience with terrestrial reactors, could enable the affordable development of space fission power systems for near-term planetary surface applications.

  1. Structure and Development of Management Information System in Furniture Enterprises

    OpenAIRE

    Qiumei Zhang

    2014-01-01

    Under the drive of the booming development of information technology, some furniture enterprises construct Management Information System (MIS) to acquire competitive advantages. This research was conducted by literature research method to determine the structure and development of management information system in Furniture Enterprises. Generally speaking, MIS in furniture enterprises mainly consists of sub-system of production and manufacture, sub-system of marketing, sub-system of materials ...

  2. Development of fluid system design technology for integral reactor

    International Nuclear Information System (INIS)

    The SMART system design development consists of two phases. In the phase 1, the conceptual design is performed to determine the design criteria and establish the system concepts. In the phase 2, the basic design stage, more detailed system analyses were carried out and as a result, the system concepts are reinforced and materialized. In this stage, in addition to the basic system design, related basic technologies are also developed. This report describes the activities and results of the project phase 2 and the contents of this report are as follows. (1) Detailed establishment of design criteria and design requirement on the SMART system design (2) Basic design on the SMART systems - Reactor coolant system - Residual heat removal system - Make-up system - Purification system - Component cooling system - Emergency core cooling system - Safeguard vessel - Reactor overpressure protection system - Desalination system (3) Development of unique analysis codes on the system design. (4) Corrosion test of material in ammonia water chemistry conditions. (5) Generation of design calculations on the basic design of the system. The results obtained through the development of the basic design of the SMART system, could produce the technical background for the detail design of the SMART system

  3. Library Systems: Current Developments and Future Directions.

    Science.gov (United States)

    Healy, Leigh Watson

    This report was commissioned in response to concerns expressed about the gap between institutional digital library initiatives and the products offered by library systems vendors. The study analyzes from the perspective of libraries the strategies, visions, and products that vendors of integrated library systems are offering as solutions. Case…

  4. MOBIL LIDAR SYSTEM DEVELOPMENTS AND OPERATING PROCEDURES

    Science.gov (United States)

    A smoke plume opacity-measuring mobile lidar system was refurbished, modified, and tested on semi-transparent screen targets. The resultant lidar system automatically analyzes, presents, and records smoke plume data, resulting in a much faster data rate and easier analysis than w...

  5. Dynamic management of sustainable development methods for large technical systems

    CERN Document Server

    Krishans, Zigurds; Merkuryev, Yuri; Oleinikova, Irina

    2011-01-01

    Paves the way for the development of new IT systems with an original approach to the management of large technical systems sustainable developmentIncludes optimal initial state methods that consider up to 60 alternative development activitiesDescribes methods that have already been tried and tested in Europe

  6. Improvement and development of main HL-1M diagnostic system

    International Nuclear Information System (INIS)

    The HL-1M diagnostic system was renewed, improved and developed based on the HL-1 diagnostic system, the developing tendency of diagnostic techniques is towards two fields, one is improving spatial and temporal resolution and another is improving intellect level of diagnostic system. These two fields were introduced

  7. Development of an Automated Rescue System

    Directory of Open Access Journals (Sweden)

    Santhoshi Shingirikonda1 , K Vanisree

    2013-08-01

    Full Text Available In order to effectively provide efficient rescue system for the ships in any position if they catch fire or any other fire accidents in the ships, a kind of An Automated Rescue System is designed with ARM as its core controller, collects the fire pollutant indexes consisting of exhaust particulates, sulphur oxides, carbon oxides, as well as nitrogen oxides through different gas sensors and takes advantage of Global Position System(GPS to obtain the Ships exact position, after that, the information collected is sent as a SMS to the Centrecontrol computer via GSM. Moreover, in order to provide Rescue Departments convenience in supervising the Lost Ships or Fire caught ships, the system also uses Global System for Mobile Communications wireless transmission in which it alarms when the ships are caught up with fire and about sink. Practical run shows that the system is well realized with the function of GPS positioning, remote data transmission, Sensing the fire emitted gasses and the precision of the system is not more the 2,5 percentage.

  8. MPs reminded of responsibilities

    Index Scriptorium Estoniae

    2011-01-01

    Riigikogult valitsuse moodustamiseks volituse saanud peaminister Andrus Ansip tutvustas ministrikandidaate president Toomas Hendrik Ilvesele. Presidendi kõnest Riigikogu XII koosseisu avaistungil 4. apr. 2011

  9. Embed XRF Data Processing System Development

    International Nuclear Information System (INIS)

    This paper introduced a project of XRF data processing system. The project adopted embed processor LPC2148 as the core of the data processing. This System has equipped graph LCD and the number of dots is 320 x 240. The large capacity Secure Digital Memory Card has been used as Data memory. It could exchange data with PC by USB interface. Also, we have made some amelioration on the function of XRF data processing. This system running stably, capability credibility and using conveniently, so it has good prospect of application and extension. (authors)

  10. Radiation risks to the developing nervous system

    International Nuclear Information System (INIS)

    The present abstract book contains the abstracts of 23 papers presented at the meeting. They are dealing with the effect of pre- or postnatal irradiation on the brain morphology metabolism or development studied in mice, rats or rabbits. (MG)

  11. Development of a chemical gas sensor system

    OpenAIRE

    Reichel, Patrick

    2005-01-01

    Das Ziel dieser Arbeit war die Entwicklung eines chemischen Gas Sensor Systems für zwei spezifische Anwendungen: die Überwachung von toxischen Gasen in Gebäuden (Kohlenmonoxid und Methan) und im Freien (Kohlenmonoxid und Stickstoffdioxid). Die Entwicklung läßt sich in drei aufeinanderfolgende Schritte einteilen: Erstens, Planung, Design und Prüfung der ersten Prototypen. Zweitens, die Prüfung und Bewertung des Systems im Labor. Drittens, der Transfer in reale Anwendungen. Das entw...

  12. Standardization of information systems development processes and banking industry adaptations

    CERN Document Server

    Tanrikulu, Zuhal

    2011-01-01

    This paper examines the current system development processes of three major Turkish banks in terms of compliance to internationally accepted system development and software engineering standards to determine the common process problems of banks. After an in-depth investigation into system development and software engineering standards, related process-based standards were selected. Questions were then prepared covering the whole system development process by applying the classical Waterfall life cycle model. Each question is made up of guidance and suggestions from the international system development standards. To collect data, people from the information technology departments of three major banks in Turkey were interviewed. Results have been aggregated by examining the current process status of the three banks together. Problematic issues were identified using the international system development standards.

  13. Development of Underwater Weapon Confrontation Simulation System Based on Composability

    Directory of Open Access Journals (Sweden)

    You Yanjun

    2013-01-01

    Full Text Available At the present, there have high cost, long development cycle and low efficiency in the development of underwater weapon confrontation. In this study, we present composability development method based on the technology of ontology. Several steps are described about the system development process, including the establishment of the conceptual model, conceptual model parsing, ontology model search, ontology model matching and ontology model combination and so on. We reduce further the development costs, shorten the development cycle and improve the efficiency of simulation system development by reusability and combination of model.

  14. Surveillance system for DUPIC fuel development facility (I)

    International Nuclear Information System (INIS)

    DUPIC Surveillance System is developed to process image data and radiation data together to diagnose intelligently the transportation status of the nuclear material, which makes it possible that usual DUPIC process be carried out without interruption under the surveillance. We developed the neutron monitor for surveillance and the system which takes and processes radiation data and image data, where the system is under the test operation after installed at DFDF (Dupic Fuel Development Facility)

  15. Surveillance system for DUPIC fuel development facility (I)

    Energy Technology Data Exchange (ETDEWEB)

    Kim, D. Y.; Kim, H. D.; Park, C. S.; Cha, H. R.; Hong, J. S.; Yang, M. S. [KAERI, Taejon (Korea, Republic of)

    2000-05-01

    DUPIC Surveillance System is developed to process image data and radiation data together to diagnose intelligently the transportation status of the nuclear material, which makes it possible that usual DUPIC process be carried out without interruption under the surveillance. We developed the neutron monitor for surveillance and the system which takes and processes radiation data and image data, where the system is under the test operation after installed at DFDF (Dupic Fuel Development Facility)

  16. Development of a Compact Tritium Gas Recycling System

    International Nuclear Information System (INIS)

    JAERI has been developing an improved compact tritium gas enrichment/recycling system for efficient research and development work using tritium. A proton conductor has been investigated and a compact enrichment system was designed with a hydrogen pump employing a proton conductor. The pump can separate hydrogen directly from the helium gas carrier and minimize the size of the system. A prototype hydrogen pump was developed and its performance test was started.

  17. Development and Design of Tourism Destination Marketing System

    Directory of Open Access Journals (Sweden)

    Zhu Zhengjie

    2013-01-01

    Full Text Available The 21st century is the age of rapid development the information industry. As one of important pillar industries of national economy in the future, tourism industry must adapt to the information wave. From the view of development and construction of the system, this study attempts to develop and design the Tourism Destination Marketing System (TDMS, focusing on systematic service analysis and structure design. The results can provide the reference information for building a destination marketing system.

  18. ALLERGIC ASTHMA AND THE DEVELOPING IMMUNE SYSTEM: A PILOT STUDY

    Science.gov (United States)

    Rationale: The predisposition towards atopic disease begins early in life, and that the risk of developing asthma is heightened following prenatal exposure to some compounds. Nonetheless, the effect of gestational aeroallergen exposure on the developing immune system is unclear....

  19. Development of the infrared target simulation system

    Science.gov (United States)

    Meng, Xiangkai; Tong, Shoufeng; Dong, Yan; Song, Yansong; Dong, Keyan

    2014-11-01

    In order to provide a set of field test equipment for the infrared system of modern weapon equipments and other optics instruments, a set of large-scale resistance-type infrared target system was designed. First, the large-scale infrared target was designed in modular construction. It was decomposed into several independent and controllable units. Then the working principle of the system was introduced. Three modes of thermal exchange (conduction, convection and radiation) and the computing methods for each mode were given under thermal equilibrium conditions through modeling and simulating. Periphery electro-circuit and control software were carried out as well. Finally, the performance of the system was tested. Meanwhile novel ways of temperature compensation to improve the uniformity of the surface temperature of the target was introduced. The experimental results show that the infrared target could meet test requirements for infrared imaging weaponry which wavelengths from 8 ?m to 14 ?m. The temperature control precision can reach 0.5ms. In conclusion, the infrared target system can satisfy requirements of reliability, high precision, as well as strong anti-jamming and stabilization.

  20. GSSD: Global System for Sustainable Development

    Science.gov (United States)

    A project of the Global Accords Consortium for Sustainable Development (located at MIT), this site offers a collection of over 2,500 abstracted, indexed, and cross-referenced online resources on sustainable development. Users have four options for searching the index: text (keyword and advanced) and three graphical browsers, one indexing all holdings (organized by subject and problems and solutions), the others covering industry related topics and the Alliance for Global Sustainability (AGS), respectively. Initial search returns include title, "slice" (subject), and "ring" (problem area). Item titles link to further information, including an abstract and the resource itself. GSSD also features a modest selection of full-text reports on "scientific developments and/or policy deliberations." The Consortium plans to make the entire knowledge base available in at least nine additional languages in the future.

  1. Development of a coal cleaning control system

    Energy Technology Data Exchange (ETDEWEB)

    Conkle, H.N.; Barnes, R.H.; Orban, J.E.; Webb, P.R.

    1990-03-09

    The US Department of Energy selected the Battelle-Electric Power Research Institute-Science Applications International Corporation team to evaluate and develop on-line slurry ash, percent solids, and sulfur analysis instrumentation and process control technology. The project's objectives were (1) to develop an accurate, versatile, easy to use, on-line coal slurry analyzer and (2) to develop control strategies for analysis, control, and optimization of advanced and conventional coal-cleaning plant. The project's scope included (1) the installation of a slurry test loop, ash, percent solids, and sulfur instruments; (2) evaluation of instrument accuracy with various coals, under various slurry conditions; and (3) assessment of the cost and benefits to be derived from on-line analysis and control 12 refs., 40 figs., 16 tabs.

  2. Development of blanket remote maintenance system

    International Nuclear Information System (INIS)

    ITER in-vessel components such as blankets are scheduled maintenance components, including complete shield blanket replacement for breeding blankets. In-vessel components are activated by 14 MeV neutrons, so blanket maintenance requires remote handling equipment and tools able to handle heavy payloads of about 4 tons within a positioning accuracy of 2 mm under intense gamma radiation. To facilitate remote maintenance, blankets are segmented into 730 modules and rail-mounted vehicle remote maintenance was developed. According to the ITER R and D program, critical technology related to blanket maintenance was developed extensively through joint efforts of the Japan, EU, and U.S. home teams. This paper summarizes current blanket maintenance technology conducted by the Japan Home Team, including development of full-scale remote handling equipment and tools for blanket maintenance. (author)

  3. Development of divertor remote maintenance system

    International Nuclear Information System (INIS)

    The ITER divertor is categorized as a scheduled maintenance component because of extreme heat and particle loads it is exposed to by plasma. It is also highly activated by 14 MeV neutrons. Reliable remote handling equipment and tools are required for divertor maintenance under intense gamma radiation. To facilitate remote maintenance, the divertor is segmented into 60 cassettes, and each cassette weighing about 25 tons and maintained and replaced through four maintenance ports each 90 degrees. Divertor cassettes must be transported toroidally and radially for replacement through maintenance ports. Remote handling involving cassette movers and carriers for toroidal and radial transport has been developed. Under the ITER R and D program, technology critical to divertor cassette maintenance is being developed jointly by Japan, E.U., and U.S. home teams. This paper summarizes divertor remote maintenance design and the status of technology development by the Japan Home Team. (author)

  4. Mechanical systems development of integral reactor

    Energy Technology Data Exchange (ETDEWEB)

    Park, Keun Bae; Chang, M. H.; Kim, J. I.; Choi, S.; Kim, K. S.; Kim, T. W.; Jeong, K. H.; Kim, J. H.; Kim, Y. W.; Lee, G. M.

    1997-07-01

    While Korean nuclear reactor strategy seems to remain focused on the large capacity power generation, it is expected that demand of small and medium size reactor will arise for multi-purpose applications such as small capacity power generation, co-generation and sea water desalination. This in mind, survey has been made on the worldwide small and medium integral reactors under development. Reviewed are their technical characteristics, development status, design features, application plans, etc. For the mechanical design scope of work, the structural concept compatible with the characteristics and requirements of integral reactor has been established. Types of major components were evaluated and selected. Functional and structural concept, equipment layout and supporting concept within the reactor pressure vessel have also been established. Preliminary mechanical design requirements were developed considering the reactor lifetime, operation conditions, and the expected loading combinations. To embody the concurrent design approach, recent CAD technology and team engineering concept were evaluated. (author). 31 refs.,16 tabs., 35 figs.

  5. Gas cooled fuel cell systems technology development

    Science.gov (United States)

    Canton, M. H.; Chepanoske, W. A.; Feret, J. M.; France, L. L.; Haines, N. L.; Heberling, C. F.; Holman, R. R.; Kelly, J. L.; Kochka, E. L.

    1992-03-01

    The development is reported of a Phosphoric Acid Fuel Cell (PAFC) for electric utility or industrial power plant applications. Results of this effort include: (1) development of a baseline rolled electrode technology; (2) advancement of fuel cell technology through improvements in the areas of acid management, catalyst selection, electrode and plate materials and processes, components designs, and quality assurance programs; (3) demonstration of improved fuel cell and stack performance and endurance; (4) successful scaleup of cell and stack design features into fun height 100 kill stacks; and (5) demonstration of combining stacks into a 400 kill module that will be the building block for power plants, including the development of testing facilities and operating procedures applicable to plant operations.

  6. Configurable technology development for reusable control and monitor ground systems

    Science.gov (United States)

    Uhrlaub, David R.

    1994-01-01

    The control monitor unit (CMU) uses configurable software technology for real-time mission command and control, telemetry processing, simulation, data acquisition, data archiving, and ground operations automation. The base technology is currently planned for the following control and monitor systems: portable Space Station checkout systems; ecological life support systems; Space Station logistics carrier system; and the ground system of the Delta Clipper (SX-2) in the Single-Stage Rocket Technology program. The CMU makes extensive use of commercial technology to increase capability and reduce development and life-cycle costs. The concepts and technology are being developed by McDonnell Douglas Space and Defense Systems for the Real-Time Systems Laboratory at NASA's Kennedy Space Center under the Payload Ground Operations Contract. A second function of the Real-Time Systems Laboratory is development and utilization of advanced software development practices.

  7. Development of PDA based application system

    International Nuclear Information System (INIS)

    Personal Digital Assistant or also known as PDA is finding wider acceptance among users as it represents a new technology in mobile technology. A PDA such as Pocket PC has become a powerful device due to the fact that it operates based on Windows-MobileTm-based platforms. An application that address specific needs and applications task directly targeted onto it is increasingly demanded This paper describes the tools and supporting technologies being used in ISG for developing applications for Pocket PC A simple application that has been successfully developed is presented and the experiences gained are also described. (Author)

  8. The role of Six1 in mammalian auditory system development

    OpenAIRE

    Zheng, Weiming; Huang, Li; Wei, Zhu-bo; Silvius, Derek; Tang, Bihui; Xu, Pin-xian

    2003-01-01

    The homeobox Six genes, homologues to Drosophila sine oculis (so) gene, are expressed in multiple organs during mammalian development. However, their roles during auditory system development have not been studied. We report that Six1 is required for mouse auditory system development. During inner ear development, Six1 expression was first detected in the ventral region of the otic pit and later is restricted to the middle and ventral otic vesicle within which, respectively, the vestibular and...

  9. Integrative Educational Approach Oriented Towards Software and System Development

    OpenAIRE

    Anca Juliana Stoica; Shareeful Islam

    2013-01-01

    The paper is based on our academic teaching and research work in software and system engineering to effectively develop modern, complex real-life Web application systems. It bridges the gap between academic education and industry needs and illustrates how such collaboration can be successfully developed in the IT area where technology development is rapid. Its scope covers the processes, models, technologies, people, and knowledge that have the capability to contribute to developing such syst...

  10. Multi-metaphor method: organizational metaphors in information systems development.

    OpenAIRE

    Oates, Briony June; Fitzgerald, Brian

    2007-01-01

    Conventional methods have been criticized for their positivist philosophy and for either ignoring the organizational context of information systems development (ISD) or using only a simplistic, machine-based conceptual model of organizations. We have developed an approach to enable systems developers to use a richer view of organizations and a more interpretive approach. Multi-Metaphor Method (MMM) supports developers via a range of metaphors as cognitive structuring devices to understand an ...

  11. Solar heating and cooling system design and development

    Science.gov (United States)

    1979-01-01

    The design and development of marketable solar heating and cooling systems for single family and commercial applications is described. The delivery, installation, and monitoring of the prototype systems are discussed. Seven operational test sites are discussed in terms of system performance. Problems encountered with equipment and installation were usually due to lack of skills required for solar system installation.

  12. Partnering industry to develop clinical information systems.

    Science.gov (United States)

    Hughes, Victoria; Hamer, Susan

    2012-09-01

    Over the past six months, the nursing team from the Department of Health's Informatics Directorate has been working with colleagues in industry to promote and share learning and understanding of issues surrounding the nursing profession. Team members were asked among other things to identify key questions senior nursing colleagues and suppliers should ask one another when considering the implementation of a new system for recording clinical information and extracting pertinent data. This article aims to encourage collaborative working and understanding of the importance of senior nurse involvement in choosing and delivering the right system for staff and patients. PMID:23008903

  13. Off-Grid System Development for House Car Pouch Lighting

    OpenAIRE

    Ranjit, S. S. S.; Anas, S. A.; Tan, C. F.

    2011-01-01

    Practically to electrify lighting system electricitysupply is a necessity to power the light. Thus, solar energy isknown as an alternative source to provide electricity. This paperpresents an off-grid system development for house car porchlighting system. Development of the system is composed ofphotovoltaic panel, environmental sensors, charge controller,battery and lighting loads such as florescent lamp. The off-gridsystem focuses to supply electricity in small scale which isintegrated with ...

  14. Developing Performance-Centered Systems for Higher Education

    Directory of Open Access Journals (Sweden)

    2007-01-01

    Full Text Available The experience in developing performance-centered systems for higher education has improved significantly, and practitioners have made considerable progress in elaborating a methodology. This paper discusses the convergence of thinking among various disciplines in analysis and design methodologies, and describes the key elements of the new-emerged performance support engineering development methodology. These are important for designing web-based systems, information systems, and knowledge management systems in higher education.

  15. Needs for development of criticality safety evaluation system

    International Nuclear Information System (INIS)

    This paper provides an outline of development of a new criticality safety evaluation code system. The new system includes not only continuous energy Monte Carlo codes MVP and MCNP but also JACS code system traditionally used for criticality safety assessment of nuclear fuel cycle facility in Japan. The purpose of the new code system development is criticality safety evaluation of spent nuclear fuels taking burnup credit into account and error evaluation of criticality calculations. (author)

  16. On The Development of West African Accounting System

    OpenAIRE

    Boka Moussa

    2010-01-01

    The authorities of the West African Economic and Monetary Union UEMOA fully understand that accounting plays the significant role in the process of economic development and regional integration in the member states. They decided to establish a common new accounting system, called West African Accounting System (SYSCOA). The accounting system has been developed on the initiative of the Central Bank of West African States "BCEAO". The various accounting systems previously in effect within the W...

  17. Development of intelligent operator support systems by GRS

    International Nuclear Information System (INIS)

    This paper describes the technical and ergomonic background, the current state and future trends in the development of intelligent operator support systems by GRS. Moreover, the influence of these advanced support systems on the design of control rooms will be briefly discussed. The degree and scope of automation has a high influence on the information situation of the operating personnel. Attempt is made to characterize the situation in current German NPP's and to describe the rationale for the various GRS system-developments. Following this the developed system concepts are explained, which comprise systems for a computerized operation manual, for post trip analysis, for alarm reduction and for disturbance analysis

  18. Desarrollo del Aparato Digestivo Digestive System Development

    Directory of Open Access Journals (Sweden)

    Ignacio Roa

    2012-12-01

    Full Text Available El aparato digestivo deriva del endodermo y el mesodermo, que forman su epitelio y la musculatura lisa respectivamente. Al igual que en el resto de los sistemas, existe un interacción epitelio-mesenquimática mediada por moléculas como Hedgehog, BMP y FoxF1 que determinan el crecimiento intestinal en sus ejes principales. Los genes Hox, junto con el resto de las moléculas, participan en la regionalización del sistema digestivo. En sus inicios lo denominaremos intestino primitivo, formado por un tubo endodérmico que deriva del saco vitelino; dividiéndose en intestino anterior, medio y posterior. En esta revisión veremos cómo estos 3 segmentos darán origen a las diferentes estructuras del sistema digestivo en los vertebrados.The digestive system is derived from the endoderm and mesoderm, which form its epithelium and smooth muscle, respectively. As in the other systems, there is an epithelial-mesenchymal interactions mediated by molecules such as Hedgehog, BMP and FoxF1, determining intestinal growth in the main axes. The Hox genes, together the rest of the molecules, involved in the regionalization of the digestive system. In the beginning we call it primitive gut, consisting of a tube derived of endodermal yolk sac, divided into foregut, midgut and hindgut. In this review we will see how these 3 segments give rise to different structures of the digestive system in vertebrates.

  19. Desarrollo del Aparato Digestivo / Digestive System Development

    Scientific Electronic Library Online (English)

    Ignacio, Roa; Manuel, Meruane.

    1285-12-01

    Full Text Available SciELO Chile | Language: Spanish Abstract in spanish El aparato digestivo deriva del endodermo y el mesodermo, que forman su epitelio y la musculatura lisa respectivamente. Al igual que en el resto de los sistemas, existe un interacción epitelio-mesenquimática mediada por moléculas como Hedgehog, BMP y FoxF1 que determinan el crecimiento intestinal en [...] sus ejes principales. Los genes Hox, junto con el resto de las moléculas, participan en la regionalización del sistema digestivo. En sus inicios lo denominaremos intestino primitivo, formado por un tubo endodérmico que deriva del saco vitelino; dividiéndose en intestino anterior, medio y posterior. En esta revisión veremos cómo estos 3 segmentos darán origen a las diferentes estructuras del sistema digestivo en los vertebrados. Abstract in english The digestive system is derived from the endoderm and mesoderm, which form its epithelium and smooth muscle, respectively. As in the other systems, there is an epithelial-mesenchymal interactions mediated by molecules such as Hedgehog, BMP and FoxF1, determining intestinal growth in the main axes. T [...] he Hox genes, together the rest of the molecules, involved in the regionalization of the digestive system. In the beginning we call it primitive gut, consisting of a tube derived of endodermal yolk sac, divided into foregut, midgut and hindgut. In this review we will see how these 3 segments give rise to different structures of the digestive system in vertebrates.

  20. Sensors based on cytochrome P450 and CYP mimicking systems

    International Nuclear Information System (INIS)

    Cytochrome P450 enzymes (CYPs) act on more than 90 percent of all drugs currently on the market. The catalytic cycle requires electron supply to the heme iron in the presence of oxygen. Electrochemistry allows to characterise the reaction mechanism of these redox enzymes by observing the electron transfer in real time. According to the number of publications on protein electrochemistry CYP has the third position after glucose oxidase and cytochrome c. CYP based enzyme electrodes for the quantification of drugs, metabolites or pesticides have been developed using different iso-enzymes. A crucial step in the sensor development is the efficiency of coupling the biocatalytic systems with the electrode is. In the 1970s the direct electron transfer of heme and heme peptides called microperoxidases (MPs) was used as model of oxidoreductases. They exhibit a broad substrate spectrum including hydroxylation of selected aromatic substrates, demethylation and epoxidation by means of hydrogen peroxide. It overlaps with that of P450 making heme and MPs to alternate recognition elements in biosensors for the detection of typical CYP substrates. In these enzyme electrodes the signal is generated by the conversion of all substrates thus representing in complex media an overall parameter. By combining the biocatalytic substrate conversion with selective binding to a molecularly imprinted polymer layer the specificity has been improved. Here we discuss different approaches of biosensors based on CYP, microperoxidases and catalytically active MIPs and discuss their potential as recognition elements in biosensors. The performance of these sensors and their further development are discussed

  1. Increased IgG on cell-derived plasma microparticles in systemic lupus erythematosus is associated with autoantibodies and complement activation

    DEFF Research Database (Denmark)

    Nielsen, Christoffer T; Østergaard, Ole

    2012-01-01

    To quantify immunoglobulin and C1q on circulating cell-derived microparticles (MPs) in patients with systemic lupus erythematosus (SLE) and to determine whether immunoglobulin and C1q levels are correlated with clinical and serologic parameters.

  2. Development of HANARO Activation Analysis System and Utilization Technology

    International Nuclear Information System (INIS)

    1. Establishment of evaluation system using a data for a neutron activation analysis : Improvement of NAA measurement system and its identification, Development of combined data evaluation code of NAA/PGAA, International technical cooperation project 2. Development of technique for a industrial application of high precision gamma nuclide spectroscopic analysis : Analytical quality control, Development of industrial application techniques and its identification 3. Industrial application research for a prompt gamma-ray activation analysis : Improvement of Compton suppression counting system (PGAA), Development of applied technology using a PGAA system 4. Establishment of NAA user supporting system and KOLAS management : Development and validation of KOLAS/ISO accreditation testing and identification method, Cooperation researches for a industrial application, Establishment of integrated user analytical supporting system, Accomplishment of sample irradiation facility

  3. Help for the Developers of Control System Cyber Security Standards

    Energy Technology Data Exchange (ETDEWEB)

    Robert P. Evans

    2008-05-01

    A Catalog of Control Systems Security: Recommendations for Standards Developers (Catalog), aimed at assisting organizations to facilitate the development and implementation of control system cyber security standards, has been developed. This catalog contains requirements that can help protect control systems from cyber attacks and can be applied to the Critical Infrastructures and Key Resources of the United States and other nations. The requirements contained in the catalog are a compilation of practices or various industry bodies used to increase the security of control systems from both physical and cyber attacks. They should be viewed as a collection of recommendations to be considered and judiciously employed, as appropriate, when reviewing and developing cyber security standards for control systems. The recommendations in the Catalog are intended to be broad enough to provide any industry using control systems the flexibility needed to develop sound cyber security standards specific to their individual security requirements.

  4. Development of HANARO Activation Analysis System and Utilization Technology

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Y. S.; Moon, J. H.; Cho, H. J. (and others)

    2007-06-15

    1. Establishment of evaluation system using a data for a neutron activation analysis : Improvement of NAA measurement system and its identification, Development of combined data evaluation code of NAA/PGAA, International technical cooperation project 2. Development of technique for a industrial application of high precision gamma nuclide spectroscopic analysis : Analytical quality control, Development of industrial application techniques and its identification 3. Industrial application research for a prompt gamma-ray activation analysis : Improvement of Compton suppression counting system (PGAA), Development of applied technology using a PGAA system 4. Establishment of NAA user supporting system and KOLAS management : Development and validation of KOLAS/ISO accreditation testing and identification method, Cooperation researches for a industrial application, Establishment of integrated user analytical supporting system, Accomplishment of sample irradiation facility.

  5. Development of cask and transportation system

    International Nuclear Information System (INIS)

    The purpose of this project is to develop the technology of UF4 production from depleted UF6, in order to utilize it as a raw material for the production of depleted uranium (DU) metal. The DU metal is to be used as a shielding material for the manufacturing of the large spent fuel cask, which is to be developed in the near future. The process is that the depleted UF6 is reduced to UF4, with hydrogen in a vertical pipe reactor. The pilot plant(30kg-U/hr) for UF4 production was installed and test operation was conducted. The produced UF4 was of good color, of fine particle size (5-10 ?m), of high purity (>98 5UE.), and had high tap density (3.7-4.3 g/cm3). (Author)

  6. Development of leakage monitoring system using radioisotopes

    Energy Technology Data Exchange (ETDEWEB)

    Lee, J. C.; Lee, D. S. [Seoil College, Seoul (Korea); Cho, Y. S. [Konyang University, Nonsan (Korea); Shin, S. K. [Sungkyunkwan Univ., Seoul (Korea)

    2000-04-01

    This study is to development the potable neutron back-scattering gauge for leakage and detecting liquid interface of an oil and liquid tank, using a radioisotopes. For this purpose, small sized, light weight potable gauge is to be designed as to develope neutron shielding mechanism, low power supply circuit, high voltage circuit, measurement circuit, and operating handle etc. The user will be able to set the duration of the time interval, the scale, the high voltage, the threshold, the channel window, the selection whether the data storage or not, the selection whether the scale, high voltage, threshold and window fix or not at any time. The counted pulse will be displayed with the numerical value and the line bar. The gauge will be able to connect to an IBM compatible PC via a serial port, power will be supplied by internal battery. 9 refs., 28 figs., 10 tabs. (Author)

  7. Biocatalytic process development using microfluidic miniaturized systems

    DEFF Research Database (Denmark)

    Krühne, Ulrich; Heintz, SØren

    2014-01-01

    The increasing interest in biocatalytic processes means there is a clear need for a new systematic development paradigm which encompasses both protein engineering and process engineering. This paper argues that through the use of a new microfluidic platform, data can be collected more rapidly and integrated with process modeling, can provide the basis for validating a reduced number of potential processes. The miniaturized platform should use a smaller reagent inventory and make better use of precious biocatalysts. The EC funded BIOINTENSE project will use ?-transaminase based synthesis of chiral amines as a test-bed for assessing the viability of such a high throughput biocatalytic process development, and in this paper, such a vision for the future is presented.

  8. Development of advanced PWR system analysis technology

    International Nuclear Information System (INIS)

    The scope of this project is to establish the basic analysis technologies for the advanced designed with the passive and inherent safety concepts. The scope is extended to the application of these technologies to the performance and safety analysis of the passive reactor. Since the different design concepts are applied depending on the reactor power, the study is conducted for the small and medium sized integral reactor as well as the large scale passive reactors by focusing on the analysis technology development for the passive components. The design concepts which can be applied for the safety enhancement of the domestic advanced reactor are developed through evaluating the technical information of the overseas advanced reactor concepts

  9. Heat recovery/seed recovery system development

    International Nuclear Information System (INIS)

    Under U.S. Department of Energy (DOE) contract BandW has been designing and developing the technology base for the design of the ETF, the commercial demonstration MHD electric power plant. The portions of the technology that are similar to commercial units includes water- and steam-side heat transfer, mechanical arrangement and stress analysis, fabrication and assembly methods, welding, heat treating, nondestructive testing, and others. 3 refs

  10. Development of Zigbee Based Energy Management System

    Directory of Open Access Journals (Sweden)

    Srinidhi G A

    2013-12-01

    Full Text Available The ZigBee pro was developed to provide low-power, wireless connectivity for a Wide range of network applications concerned with monitoring and control.ZigBee is a worldwide open standard controlled by the ZigBee Alliance. ZigBee PRO is an Enhancement of the original ZigBee protocol, providing a number of extra features that are particularly useful for very large networks (that may include hundreds or even thousands of nodes.

  11. Development of Zigbee Based Energy Management System

    OpenAIRE

    Srinidhi G A; Shivakumar, Dr K. B.; Sagar K N; Krishnamurthy, Dr K. A.

    2013-01-01

    The ZigBee pro was developed to provide low-power, wireless connectivity for a Wide range of network applications concerned with monitoring and control.ZigBee is a worldwide open standard controlled by the ZigBee Alliance. ZigBee PRO is an Enhancement of the original ZigBee protocol, providing a number of extra features that are particularly useful for very large networks (that may include hundreds or even thousands of nodes.

  12. NADIR: A Flexible Archiving System Current Development

    Science.gov (United States)

    Knapic, C.; De Marco, M.; Smareglia, R.; Molinaro, M.

    2014-05-01

    The New Archiving Distributed InfrastructuRe (NADIR) is under development at the Italian center for Astronomical Archives (IA2) to increase the performances of the current archival software tools at the data center. Traditional softwares usually offer simple and robust solutions to perform data archive and distribution but are awkward to adapt and reuse in projects that have different purposes. Data evolution in terms of data model, format, publication policy, version, and meta-data content are the main threats to re-usage. NADIR, using stable and mature framework features, answers those very challenging issues. Its main characteristics are a configuration database, a multi threading and multi language environment (C++, Java, Python), special features to guarantee high scalability, modularity, robustness, error tracking, and tools to monitor with confidence the status of each project at each archiving site. In this contribution, the development of the core components is presented, commenting also on some performance and innovative features (multi-cast and publisher-subscriber paradigms). NADIR is planned to be developed as simply as possible with default configurations for every project, first of all for LBT and other IA2 projects.

  13. Development of cryogen free Ic measurement system

    International Nuclear Information System (INIS)

    The increasing use of high-temperature superconducting (HTS) materials for advanced power applications has generated much interest in the acquisition of the voltage-current (V-I) characteristic curve to measure the critical current (Ic) of HTS tape. Cryogen free Ic measurement system for HTS wires or coils was designed and fabricated by using a GM-cryocooler and two HTS current leads. The sample cools conductively by 2nd stage of SRDK-408D cryocooler manufactured by Sumitomo Heavy Industries Ltd. (SHI). Each high temperature end of HTS current leads is thermally connected to 1st stage of the cryocooler and electrically disconnected. HTS tape samples cooled down by about 10 K. Ic measurements were conducted on a BSCCO-2212 tape, a BSCCO-2223 tape with joints and a BSCCO-2223 small coil under self-field. A description of cryogen free Ic measurement system design and results from a series of measurements will be presented

  14. A liquid xenon development and test system

    Science.gov (United States)

    Giboni, K. L.; Ji, X.; Lin, H.; Tan, A.; Ye, T.; Zhang, Y.; Zhao, L.

    2014-04-01

    Large liquid xenon detectors became rather popular in the last years, especially for Dark Matter searches. However, each new experiment or application presents its own specifications and requirements which first have to be explored with a small set up. Although much cheaper and easier to operate, a small liquid xenon system is nearly as complex as a large one. A small test set up is described as platform for such preliminary tests. The set up was thoroughly tested during the last two years of operation, and there are four identical systems running in different labs. The design is intended to be versatile and can be used as basis for similar instruments, whereas a complete new design would still cost several months of design, acquisition of parts, construction, assembly, and testing.

  15. New developments of the EAST data system

    International Nuclear Information System (INIS)

    As the discharge time becomes longer, the old EAST data system will not meet the requirements of EAST discharge experiment gradually. The problems mainly focus on continuous data acquisition and real-time data access. To meet the requirements of EAST 1000s discharges, the data acquisition mode, data storage structure and data access interface must be improved or reconstructed. Time slice mechanism is one of the popular solutions for continuous data acquisition and real-time data transfer. Data access of large signal files has been successfully solved via a hierarchical storage management system. Moreover, conventional 'remote indexing' is replaced with 'local indexing' in data access, which greatly enhanced data access speed. These improvements have been implemented and applied to EAST long-pulse plasma experiments which are described in this paper in detail.

  16. Energy systems Diagnosis in developing countries

    International Nuclear Information System (INIS)

    Energy systems diagnosis is necessary to allow evaluation of energy balance by administration and political authorities of a country. First, the author describes the principle stages of energetic diagnosis. Then this work is divided into three parts: First part: Energy consumption diagnosis in several districts (families, utilities, agriculture, transport, industry) Second part: Energy supplies diagnosis (energy markets). Third part: Interactions between energy consumption and energy supply. 28 figs.; 52 tabs.; 107 refs

  17. Development of an autonomous target tracking system

    Science.gov (United States)

    Gidda, Venkata Ramaiah

    In recent years, surveillance and border patrol have become one of the key research areas in UAV research. Increase in the computational capability of the computers and embedded electronics, coupled with compatibility of various commercial vision algorithms and commercial off the shelf (COTS) embedded electronics, and has further fuelled the research. The basic task in these applications is perception of environment through the available visual sensors like camera. Visual tracking, as the name implies, is tracking of objects using a camera. The process of autonomous target tracking starts with the selection of the target in a sequence of video frames transmitted from the on-board camera. We use an improved fast dynamic template matching algorithm coupled with Kalman Filter to track the selected target in consecutive video frames. The selected target is saved as a reference template. On the ground station computer, the reference template is overlaid on the live streaming video from the on-board system, starting from the upper left corner of the video frame. The template is slid pixel by pixel over the entire source image. A comparison of the pixels is performed between the template and source image. A confidence value R of the match is calculated at each pixel. Based on the method used to perform the template matching, the best match pixel location is found according to the highest or lowest confidence value R. The best match pixel location is communicated to the on-board gimbal controller over the wireless Xbee network. The software on the controller actuates the pan-tilt servos to continuously to hold the selected target at the center of the video frame. The complete system is a portable control system assembled from commercial off the shelf parts. The tracking system is tested on a target having several motion patterns.

  18. Developing Semantically Interoperable E-Commerce Systems

    OpenAIRE

    Diggelen, J.; Dignum, F. P. M.

    2007-01-01

    This paper discusses semantic interoperability issues in agentbased E-commerce systems. The literature reports various techniques to enable agents to understand the meanings of the messages exchanged. We will argue how these different techniques can be combined in one agent communication protocol to obtain the best of each world. The resulting communication protocol enables agents to sufficiently understand each other to participate in successful collaboration.

  19. Geographic Information Systems and Web Page Development

    Science.gov (United States)

    Reynolds, Justin

    2004-01-01

    The Facilities Engineering and Architectural Branch is responsible for the design and maintenance of buildings, laboratories, and civil structures. In order to improve efficiency and quality, the FEAB has dedicated itself to establishing a data infrastructure based on Geographic Information Systems, GIS. The value of GIS was explained in an article dating back to 1980 entitled "Need for a Multipurpose Cadastre" which stated, "There is a critical need for a better land-information system in the United States to improve land-conveyance procedures, furnish a basis for equitable taxation, and provide much-needed information for resource management and environmental planning." Scientists and engineers both point to GIS as the solution. What is GIS? According to most text books, Geographic Information Systems is a class of software that stores, manages, and analyzes mapable features on, above, or below the surface of the earth. GIS software is basically database management software to the management of spatial data and information. Simply put, Geographic Information Systems manage, analyze, chart, graph, and map spatial information. GIS can be broken down into two main categories, urban GIS and natural resource GIS. Further still, natural resource GIS can be broken down into six sub-categories, agriculture, forestry, wildlife, catchment management, archaeology, and geology/mining. Agriculture GIS has several applications, such as agricultural capability analysis, land conservation, market analysis, or whole farming planning. Forestry GIs can be used for timber assessment and management, harvest scheduling and planning, environmental impact assessment, and pest management. GIS when used in wildlife applications enables the user to assess and manage habitats, identify and track endangered and rare species, and monitor impact assessment.

  20. Recent Developments with the licas System 2

    OpenAIRE

    Greer, Kieran

    2014-01-01

    The licas (lightweight Internet-based communication for autonomic services) system is a Java-based open source framework for building service-based networks, similar to what you would use a Cloud or SOA platform for. The framework comes with a server for running the services on, mechanisms for adding services to the server, mechanisms for linking services with each other, and mechanisms for allowing the services to communicate with each other. The general architecture of the...