WorldWideScience
1

MPS II drift chamber system  

Energy Technology Data Exchange (ETDEWEB)

The MPS II detectors are narrow drift space chambers designed for high position resolution in a magnetic field and in a very high particle flux environment. Central to this implementation was the development of 3 multi-channel custom IC's and one multi-channel hybrid. The system is deadtimeless and requires no corrections on an anode-to-anode basis. Operational experience and relevance to ISABELLE detectors is discussed.

Platner, E.D.

1982-01-01

2

MPS II drift-chamber system  

International Nuclear Information System (INIS)

A new system of detectors (MPS II) which has been installed and operated in the Brookhaven National Laboratory Multiparticle Spectrometer (MPS), consisting of short drift distance drift chambers is briefly described

3

Development of J-PARC LINAC/RCS MPS sub system  

International Nuclear Information System (INIS)

To decrease the heat damage and the radiation damage because of the beam collision extremely, MPS of J-PARC was set up. Actually, high speed (All processes from the beam loss detection to the beam complete stop around 5? second: measurement) that almost meets a first specification and high reliability (The malfunction rate not to understand the cause is almost 0%) have been achieved though it becomes 1 and a half years by being operated in J-PARC Linac. However, it is understood that there is a demand that should be satisfied because the beam is stopped at high speed when an actual beam driving as facilities for research is considered. Then, we produced 'Logic controller', 'MWPM unit', 'Pulse pipe bend unit', and 'Trigger the checker' to satisfy these demands, and mounted it. (author)

4

MPS [Multiparticle Spectrometer] data acquisition software system  

International Nuclear Information System (INIS)

A description of the software for a FASTBUS based data acquisition system in use at the Brookhaven National Laboratory Multiparticle Spectrometer is presented. Data reading and formatting is done by the SLAC Scanner Processors (SSP's) resident in the FASTBUS system. A multiprocess software system on VAX computers is used to communicate with the SSP's, record the data, and monitor on-line the progress of high energy and heavy ion experiments. The structure and the performance of this system are discussed. 4 refs., 1 fig

5

Development status of MPS for the IFMIF/EVEDA accelerator (2)  

International Nuclear Information System (INIS)

International Fusion Materials Irradiation Facility (IFMIF) is an accelerator-based neutron irradiation facility to develop materials for a demonstration fusion reactor next to ITER. For providing materials to make a decision of IFMIF construction, Engineering Validation and Engineering Design Activities (EVEDA) under the Broader Approach agreement have been started. IFMIF/EVEDA prototype accelerator consists of Injector, a 175 MHz RFQ linac, a matching section, the first section of Superconducting RF linac, a high energy beam transport line and a beam dump, and the acceleration tests by employing the deuteron beam of 125 mA are planning in Rokkasho, Aomori, Japan. One of the control system for Linear IFMIF Prototype Accelerator (LIPAc), Machine Protection System (MPS) realize the beam rapid stop to minimize the beam loss. This paper presents the development status of the MPS, and the prospects to apply them to the Injector test. (author)

6

MPS II: adaptive behavior of patients and impact on the family system.  

Science.gov (United States)

Mucopolysaccharidosis type II (MPS II), also known as Hunter syndrome, is a chronic and progressive X-linked lysosomal disease that mainly affects males. It occurs in 1 in every 65,000 to 1 in 132,000 births. There are two distinct forms of the disease based on age of onset and clinical course: mild and severe. MPS II affects many organ systems including the nervous, cardiovascular, gastrointestinal and respiratory systems. Complications can include vision problems, progressive hearing loss, thickened and elastic skin, mental impairment, and enlarged liver and spleen. We herein focus on the adaptive behavior of individuals with MPS II, and the impact of MPS II on the family system. Outcomes from the Vineland-II Adaptive Behavior Scales showed that the MPS II patient sample experienced significantly lower functioning in communication, daily living skills, socialization, and motor skills compared to normative data. Patients with severe MPS II were found to have significantly lower adaptive functioning in all domains, as compared to those with mild MPS II. Length of time on ERT had no significant relationship to adaptive functioning. Results from the Peds QL Family Impact Module indicated that families of patients with MPS II experienced a lower overall health-related quality of life and overall lower family functioning (including lower emotional and cognitive functioning) than those with chronic illnesses residing in an inpatient setting. PMID:24190099

Needham, Mary; Packman, Wendy; Rappoport, Maxwell; Quinn, Natasha; Cordova, Matthew; Macias, Sandra; Morgan, Cynthia; Packman, Seymour

2014-06-01

7

MPS Editor  

Science.gov (United States)

Previously, it was time-consuming to hand-edit data and then set up simulation runs to find the effect and impact of the input data on a spacecraft. MPS Editor provides the user the capability to create/edit/update models and sequences, and immediately try them out using what appears to the user as one piece of software. MPS Editor provides an integrated sequencing environment for users. It provides them with software that can be utilized during development as well as actual operations. In addition, it provides them with a single, consistent, user friendly interface. MPS Editor uses the Eclipse Rich Client Platform to provide an environment that can be tailored to specific missions. It provides the capability to create and edit, and includes an Activity Dictionary to build the simulation spacecraft models, build and edit sequences of commands, and model the effects of those commands on the spacecraft. MPS Editor is written in Java using the Eclipse Rich Client Platform. It is currently built with four perspectives: the Activity Dictionary Perspective, the Project Adaptation Perspective, the Sequence Building Perspective, and the Sequence Modeling Perspective. Each perspective performs a given task. If a mission doesn't require that task, the unneeded perspective is not added to that project's delivery. In the Activity Dictionary Perspective, the user builds the project-specific activities, observations, calibrations, etc. Typically, this is used during the development phases of the mission, although it can be used later to make changes and updates to the Project Activity Dictionary. In the Adaptation Perspective, the user creates the spacecraft models such as power, data store, etc. Again, this is typically used during development, but will be used to update or add models of the spacecraft. The Sequence Building Perspective allows the user to create a sequence of activities or commands that go to the spacecraft. It provides a simulation of the activities and commands that have been created.

Mathews, William S.; Liu, Ning; Francis, Laurie K.; OReilly, Taifun L.; Schrock, Mitchell; Page, Dennis N.; Morris, John R.; Joswig, Joseph C.; Crockett, Thomas M.; Shams, Khawaja S.

2011-01-01

8

FEDERAL USERS CONFERENCE PRODUCT LINE TOOL SET (PLTS) MAP PRODUCTION SYSTEM (MPS) ATLAS CUSTOM GRIDS [Rev 0 was draft  

International Nuclear Information System (INIS)

Maps, and more importantly Atlases, are assisting the user community in managing a large land area with complex issues, the most complex of which is the management of nuclear waste. The techniques and experiences discussed herein were gained while developing several atlases for use at the US Department of Energy's Hanford Site. The user community requires the ability to locate not only waste sites, but other features as well. Finding a specific waste site on a map and in the field is a difficult task at a site the size of Hanford. To find a specific waste site, the user begins by locating the item or object in an index, then locating the feature on the corresponding map within an atlas. Locating features requires a method for indexing them. The location index and how to place it on a map or atlas is the central theme presented in this article. The user requirements for atlases forced the design team to develop new and innovative solutions for requirements that Product Line Tool Set (PLTS) Map Production System (MPS)-Atlas was not designed to handle. The layout of the most complex atlases includes custom reference grids, multiple data frames, multiple map series, and up to 250 maps. All of these functional requirements are at the extreme edge of the capabilities of PLTS MPS-Atlas. This document outlines the setup of an atlas using PLTS MPS-Atlas to meet these requirements

9

DET/MPS - THE GSFC ENERGY BALANCE PROGRAM, DIRECT ENERGY TRANSFER/MULTIMISSION SPACECRAFT MODULAR POWER SYSTEM (DEC VAX VMS VERSION)  

Science.gov (United States)

The DET/MPS programs model and simulate the Direct Energy Transfer and Multimission Spacecraft Modular Power System in order to aid both in design and in analysis of orbital energy balance. Typically, the DET power system has the solar array directly to the spacecraft bus, and the central building block of MPS is the Standard Power Regulator Unit. DET/MPS allows a minute-by-minute simulation of the power system's performance as it responds to various orbital parameters, focusing its output on solar array output and battery characteristics. While this package is limited in terms of orbital mechanics, it is sufficient to calculate eclipse and solar array data for circular or non-circular orbits. DET/MPS can be adjusted to run one or sequential orbits up to about one week, simulated time. These programs have been used on a variety of Goddard Space Flight Center spacecraft projects. DET/MPS is written in FORTRAN 77 with some VAX-type extensions. Any FORTRAN 77 compiler that includes VAX extensions should be able to compile and run the program with little or no modifications. The compiler must at least support free-form (or tab-delineated) source format and 'do do-while end-do' control structures. DET/MPS is available for three platforms: GSC-13374, for DEC VAX series computers running VMS, is available in DEC VAX Backup format on a 9-track 1600 BPI tape (standard distribution) or TK50 tape cartridge; GSC-13443, for UNIX-based computers, is available on a .25 inch streaming magnetic tape cartridge in UNIX tar format; and GSC-13444, for Macintosh computers running AU/X with either the NKR FORTRAN or AbSoft MacFORTRAN II compilers, is available on a 3.5 inch 800K Macintosh format diskette. Source code and test data are supplied. The UNIX version of DET requires 90K of main memory for execution. DET/MPS was developed in 1990. A/UX and Macintosh are registered trademarks of Apple Computer, Inc. VMS, DEC VAX and TK50 are trademarks of Digital Equipment Corporation. UNIX is a registered trademark of AT&T Bell Laboratories.

Jagielski, J. M.

1994-01-01

10

DET/MPS - THE GSFC ENERGY BALANCE PROGRAM, DIRECT ENERGY TRANSFER/MULTIMISSION SPACECRAFT MODULAR POWER SYSTEM (MACINTOSH A/UX VERSION)  

Science.gov (United States)

The DET/MPS programs model and simulate the Direct Energy Transfer and Multimission Spacecraft Modular Power System in order to aid both in design and in analysis of orbital energy balance. Typically, the DET power system has the solar array directly to the spacecraft bus, and the central building block of MPS is the Standard Power Regulator Unit. DET/MPS allows a minute-by-minute simulation of the power system's performance as it responds to various orbital parameters, focusing its output on solar array output and battery characteristics. While this package is limited in terms of orbital mechanics, it is sufficient to calculate eclipse and solar array data for circular or non-circular orbits. DET/MPS can be adjusted to run one or sequential orbits up to about one week, simulated time. These programs have been used on a variety of Goddard Space Flight Center spacecraft projects. DET/MPS is written in FORTRAN 77 with some VAX-type extensions. Any FORTRAN 77 compiler that includes VAX extensions should be able to compile and run the program with little or no modifications. The compiler must at least support free-form (or tab-delineated) source format and 'do do-while end-do' control structures. DET/MPS is available for three platforms: GSC-13374, for DEC VAX series computers running VMS, is available in DEC VAX Backup format on a 9-track 1600 BPI tape (standard distribution) or TK50 tape cartridge; GSC-13443, for UNIX-based computers, is available on a .25 inch streaming magnetic tape cartridge in UNIX tar format; and GSC-13444, for Macintosh computers running AU/X with either the NKR FORTRAN or AbSoft MacFORTRAN II compilers, is available on a 3.5 inch 800K Macintosh format diskette. Source code and test data are supplied. The UNIX version of DET requires 90K of main memory for execution. DET/MPS was developed in 1990. A/UX and Macintosh are registered trademarks of Apple Computer, Inc. VMS, DEC VAX and TK50 are trademarks of Digital Equipment Corporation. UNIX is a registered trademark of AT&T Bell Laboratories.

Jagielski, J. M.

1994-01-01

11

Local Government Finance in Ghana: Disbursement and Utilisation of the MPs share of the District Assemblies Common Fund  

OpenAIRE

The establishment of the District Assembly Common Fund (DACF) in 1993 and concomitant percentage set aside for Members of Parliament (MPs) in 2004 aims to support local governments and legislators in pro-poor development activities in their communities and constituencies. In spite of the importance of the MPs’ share of the District Assemblies Common Fund (MPsCF) in financing local level development in Ghana, very little is known about monitoring systems and procedures on the disbursement an...

Nana Nimo Appiah-Agyekum

2013-01-01

12

J-PARC accelerator MPS functionality for high availability  

International Nuclear Information System (INIS)

In this paper, the project to improve J-PARC MPS (Machine Protection System) will be reported. Current J-PARC MPS stops the delivery of the beam to all J-PARC complex, when MPS events from any components in the system is triggered. MLF (Material and Life science Facility) receives beams from RCS directly. Some of MPS events in MR, HD (Hadron Facility) or NU (Neutrino Facility) does not affect the quality of beams to MLF at all. These events should not stop the delivery of the beam to MLF. We designed a new or improve J-PARC MPS to accept two levels of MPS signal from MR, HD and NU. In the new MPS system, some MPS events, classified as 'MR Inhibit', prevents the delivery of the beam to MR but allows the delivery of the beam to MLF. The design of this new MPS and the status of the installation is described in this report. (author)

13

The MPS1 family of protein kinases.  

Science.gov (United States)

MPS1 protein kinases are found widely, but not ubiquitously, in eukaryotes. This family of potentially dual-specific protein kinases is among several that regulate a number of steps of mitosis. The most widely conserved MPS1 kinase functions involve activities at the kinetochore in both the chromosome attachment and the spindle checkpoint. MPS1 kinases also function at centrosomes. Beyond mitosis, MPS1 kinases have been implicated in development, cytokinesis, and several different signaling pathways. Family members are identified by virtue of a conserved C-terminal kinase domain, though the N-terminal domain is quite divergent. The kinase domain of the human enzyme has been crystallized, revealing an unusual ATP-binding pocket. The activity, level, and subcellular localization of Mps1 family members are tightly regulated during cell-cycle progression. The mitotic functions of Mps1 kinases and their overexpression in some tumors have prompted the identification of Mps1 inhibitors and their active development as anticancer drugs. PMID:22482908

Liu, Xuedong; Winey, Mark

2012-01-01

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Replacement of heavy components of the Main Primary System (MPS). Recent innovations made by Framatome ANP  

International Nuclear Information System (INIS)

The replacement of heavy components is the result of widespread stress corrosion of Inconel 600 (and alloys 82/182) in the primary system. Following the corrosion of steam generator tubes, which led to the first steam generator replacement (SGR) operations, work has begun on reactor vessel head replacements (RVHR) and pressurizer replacements, pending treatment of the dissimilar butt welds (DBW). The replacement of sections of the Main Primary System is one way of optimizing plant lifetime besides preventing stress corrosion in primary components and combating phenomena as thermal fatigue or certain metallurgical weaknesses. The increase in the number of major operations carried out in the reactor building on PWR and BWR reactor geometries has called for major technical innovations. AREVA, has over the past twenty years carried out more than forty SGRs throughout the world, including the supply of 115 steam generators of all types. This equates to over 60% of all SGR operations performed in Europe and the USA. Today, most SGR operations are performed in the USA, though some still continue in Europe and Asia. Operations have been planned until 2015. The first RVHR operations were carried out in France in 1993, and have been widespread in Europe since 1996 (Spain and Belgium), and in the USA since 2002 (Davis Besse). Since 1993 AREVA, through its subsidiaries Framatome ANP, Jeumont SA and SGT, has performed 72 RVHRs, i.e. most of those carried out in Europe and the USA.f those carried out in Europe and the USA. Today, RVHR operations take place throughout the world and have been planned until 2014. The first pressurizer replacement took place in the fall of 2005 in Saint Lucie, USA. Others are to follow (Fort Calhoun, Millestone). A significant number of partial or complete pressurizer replacements are now being scheduled. Special focus must be given to this new operation, as a decision is required between the following types of replacements, taking into account the number of pressurizer heaters and the condition of the various penetrations (lateral or from above, for instrumentation, unloading, spraying, etc.): - Complete replacement of the component (including dissimilar metal welds, thermal sleeves and even a section of the surge line if necessary); - Bottom replacement; - Replacement of faulty penetrations only. Along with the regular replacement of molded Main Primary System elbows (SGR operations), the following actions have also been carried out: - Replacement of a half crossover leg (SGR-GR4, 2000); - Replacement of a cold leg section (RCLS) with a chemical and volume control system (CVCS) nozzle (SGR-FH1, 2002). In the future we predict work will be carried out on the pressurizer surge line (potentially carried out as part of a pressurizer changeover or as a stand-alone operation). This presentation will focus on the major innovations developed by Framatome ANP, aided by its international customers in order to carry out these primary component replacement operations as well and as quickly as possible. These innovations concern the following domains: - Hoisting and handling; - Metrology and topo-metry; - Machining and welding; - Automated operations in piping; - Operation management. In conclusion one stresses that to increase the lifetime of their nuclear plants, optimize outages and sometimes increase thermal and electrical power it is necessary to optimize the replacement of heavy primary components. To meet the operator needs, suppliers must in turn enhance their capacity and skills in terms of: - Providing near-turnkey services (supplies and work); - Orchestrating these operations (i.e. by performing the duties of an engineering department); - Providing services in a range of fields, from concrete to instrumentation and control, and even performance testing; - Being technically innovative in all of these areas. Since the 1990's, with the assistance of its worldwide customer base, Framatome ANP has been carrying out this approach thanks to its experience as a vendor and manufacturer (OEM), bolstered by the capa

15

Development of the machine protection system for LCLS-I  

International Nuclear Information System (INIS)

Machine Protection System (MPS) requirements for the currently operating Linac Coherent Light Source (LCLSI) demand that fault detection and mitigation occur within one machine pulse (1/120 of a second at full beam rate). The MPS must handle inputs from a variety of sources including loss monitors as well as standard state-type inputs. These sensors exist at various places across the full 2.5 Km length of the accelerator and beam lines. A new MPS has been developed based on a distributed star network where custom-designed local hardware nodes handle sensor inputs and mitigation outputs for localized regions of the LCLS accelerator complex. These Link- Nodes report status information and receive action commands from a centralized processor running the MPS algorithm over a private network. The individual Link-Node is a 3u chassis with configurable hardware components that can be setup with digital and analog inputs and outputs, depending upon the sensor and actuator requirements. Features include a custom MPS digital input/output subsystem, a private Ethernet interface, an embedded processor, a custom MPS engine implemented in an FPGA and an Industry Pack (IP) bus interface, allowing COTS and custom analog/digital I/O modules to be utilized for MPS functions. These features, while capable of handling standard MPS state-type inputs and outputs, allow other systems like beam loss monitors to be completely integrated within it. To date, four different types of Link-Nodes adate, four different types of Link-Nodes are in use in LCLS-I. This paper describes the design, construction and implementation of the LCLS MPS with a focus on the Link-Node, which has proven to be a very useful and flexible component for the MPS. (authors)

16

Small Molecule Kinase Inhibitors Provide Insight into Mps1 Cell Cycle Function  

OpenAIRE

Mps1, a dual-specificity kinase, is required for the proper functioning of the spindle assembly checkpoint and the maintenance of chromosomal stability. As Mps1 function has been implicated in numerous phases of the cell cycle, it is expected the development of a potent, selective small molecule inhibitor of Mps1 would greatly facilitate dissection of Mps1-related biology. We describe the cellular effects and Mps1 co-crystal structures of novel, selective small molecule inhibitors of Mps1. Co...

Kwiatkowski, Nicholas; Jelluma, Nannette; Filippakopoulos, Panagis; Soundararajan, Meera; Manak, Michael S.; Kwon, Mijung; Choi, Hwan Geun; Sim, Taebo; Deveraux, Quinn L.; Rottmann, Sabine; Pellman, David; Shah, Jagesh V.; Kops, Geert J. P. L.; Knapp, Stefan; Gray, Nathanael S.

2010-01-01

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Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function.  

OpenAIRE

Mps1, a dual-specificity kinase, is required for the proper functioning of the spindle assembly checkpoint and for the maintenance of chromosomal stability. As Mps1 function has been implicated in numerous phases of the cell cycle, the development of a potent, selective small-molecule inhibitor of Mps1 should facilitate dissection of Mps1-related biology. We describe the cellular effects and Mps1 cocrystal structures of new, selective small-molecule inhibitors of Mps1. Consistent with RNAi st...

Kwiatkowski, Nicholas; Jelluma, Nannette; Filippakopoulos, Panagis; Soundararajan, Meera; Manak, Michael S.; Kwon, Mijung; Choi, Hwan Geun; Sim, Taebo; Deveraux, Quinn L.; Rottmann, Sabine; Pellman, David; Shah, Jagesh V.; Kops, Geert J. P. L.; Knapp, Stefan; Gray, Nathanael S.

2010-01-01

18

Space Shuttle Program (SSP) Orbiter Main Propulsion System (MPS) Gaseous Hydrogen (GH2) Flow Control Valve (FCV) Poppet Eddy Current (EC) Inspection Probability of Detection (POD) Study. Volume 2; Appendices  

Science.gov (United States)

The Director of the NASA Engineering and Safety Center (NESC), requested an independent assessment of the anomalous gaseous hydrogen (GH2) flow incident on the Space Shuttle Program (SSP) Orbiter Vehicle (OV)-105 during the Space Transportation System (STS)-126 mission. The main propulsion system (MPS) engine #2 GH2 flow control valve (FCV) LV-57 transition from low towards high flow position without being commanded. Post-flight examination revealed that the FCV LV-57 poppet had experienced a fatigue failure that liberated a section of the poppet flange. The NESC assessment provided a peer review of the computational fluid dynamics (CFD), stress analysis, and impact testing. A probability of detection (POD) study was requested by the SSP Orbiter Project for the eddy current (EC) nondestructive evaluation (NDE) techniques that were developed to inspect the flight FCV poppets. This report contains the Appendices to the main report.

Piascik, Robert S.; Prosser, William H.

2011-01-01

19

Space Shuttle Program (SSP) Orbiter Main Propulsion System (MPS) Gaseous Hydrogen (GH2) Flow Control Valve (FCV) Poppet Eddy Current (EC) Inspection Probability of Detection (POD) Study. Volume 1  

Science.gov (United States)

The Director of the NASA Engineering and Safety Center (NESC), requested an independent assessment of the anomalous gaseous hydrogen (GH2) flow incident on the Space Shuttle Program (SSP) Orbiter Vehicle (OV)-105 during the Space Transportation System (STS)-126 mission. The main propulsion system (MPS) engine #2 GH2 flow control valve (FCV) LV-57 transition from low towards high flow position without being commanded. Post-flight examination revealed that the FCV LV-57 poppet had experienced a fatigue failure that liberated a section of the poppet flange. The NESC assessment provided a peer review of the computational fluid dynamics (CFD), stress analysis, and impact testing. A probability of detection (POD) study was requested by the SSP Orbiter Project for the eddy current (EC) nondestructive evaluation (NDE) techniques that were developed to inspect the flight FCV poppets. This report contains the findings and recommendations from the NESC assessment.

Piascik, Robert S.; Prosser, William H.

2011-01-01

20

On the consistency of MPS  

CERN Document Server

The consistency of Moving Particle Semi-implicit (MPS) method in reproducing the gradient, divergence and Laplacian differential operators is discussed in the present paper. Its relation to the Smoothed Particle Hydrodynamics (SPH) method is rigorously established. The application of the MPS method to solve the Navier-Stokes equations using a fractional step approach is treated, unveiling inconsistency problems when solving the Poisson equation for the pressure. A new corrected MPS method incorporating boundary terms is proposed. Applications to one dimensional boundary value Dirichlet and mixed Neumann-Dirichlet problems and to two-dimensional free-surface flows are presented.

Souto-Iglesias, Antonio; González, Leo M; Cercos-Pita, Jose L

2013-01-01

21

On the consistency of MPS  

Science.gov (United States)

The consistency of the Moving Particle Semi-implicit (MPS) method in reproducing the gradient, divergence and Laplacian differential operators is discussed in the present paper. Its relation to the Smoothed Particle Hydrodynamics (SPH) method is rigorously established. The application of the MPS method to solve the Navier-Stokes equations using a fractional step approach is treated, unveiling inconsistency problems when solving the Poisson equation for the pressure. A new corrected MPS method incorporating boundary terms is proposed. Applications to one dimensional boundary value Dirichlet and mixed Neumann-Dirichlet problems and to two-dimensional free-surface flows are presented.

Souto-Iglesias, Antonio; Macià, Fabricio; González, Leo M.; Cercos-Pita, Jose L.

2013-03-01

22

Molecular Mechanisms Underlying KVS-1-MPS-1 Complex Assembly  

OpenAIRE

Formation of heteromeric complexes between voltage-gated K+ (Kv) channels and accessory (?) subunits is a widespread means to generate heterogeneity of K+ current in the nervous system. Here we investigate the principles that determine the interactions of Caenorhabditis elegans MPS-1, a bifunctional ?-subunit that possesses kinase activity, with Kv channels. MPS-1 belongs to the evolutionarily conserved family of KCNE ?-subunits that modulate the functional properties of a variety of Kv ch...

Wang, Yi; Sesti, Federico

2007-01-01

23

MPS beam control software architecture  

International Nuclear Information System (INIS)

The new Machine Protection System (MPS) now being tested at SLAC has a beam control subsystem resident in processors located close to the beam monitoring devices within the machine. There are two types of beam control micros: Algorithm Processors (AP's) which collect and evaluate data from monitoring devices, and a Supervisor (SUPE) which collects and evaluates data from all the AP's. The SUPE also receives the global machine beamcode indicating beam presence, and passes it on to the AP's. The SUPE receives the beamcode pattern from the Master Pattern Generator (MPG) via a shared-memory communication link. MIL-1553 serial communication is used between the SUPE and the AP's, and between the AP's and the monitoring devices. Multitasking software is used to allow high priority handling of data evaluation and low priority handling of host/user interfacing and event reporting. Pipelining of data between acquisition and evaluation and reporting is used to accommodate the processing capacity, while still supporting full processing at the 36OHz broadcast rate of the beamcode pattern

24

MPS beam control software architecture  

International Nuclear Information System (INIS)

The new Machine Protection System (MPS) now being tested at SLAC has a beam control subsystem resident in processors located close to the beam monitoring devices within the machine. There are two types of beam control micros: Algorithm Processors (AP's) which collect and evaluate data from monitoring devices, and a Supervisor (SUPE) which collects and evaluates data from all the AP's. The SUPE also receives the global machine beamcode indicating beam presence, and passes it on to the AP's. The SUPE receives the beamcode pattern from the Master Pattern Generator (MPG) via a shared-memory communication link. MIL-1553 serial communication is used between the SUPE and the AP's, and between the AP's and the monitoring devices. Multitasking software is used to allow high priority handling of data evaluation and low priority handling of host/user interfacing and event reporting. Pipelining of data between acquisition and evaluation and reporting is used to accomodate the processing capacity, while still supporting full processing at the 360Hz broadcast rate of the beamcode pattern

25

DET/MPS - The GSFC Energy Balance Programs  

Science.gov (United States)

Direct Energy Transfer (DET) and MultiMission Spacecraft Modular Power System (MPS) computer programs perform mathematical modeling and simulation to aid in design and analysis of DET and MPS spacecraft power system performance in order to determine energy balance of subsystem. DET spacecraft power system feeds output of solar photovoltaic array and nickel cadmium batteries directly to spacecraft bus. MPS system, Standard Power Regulator Unit (SPRU) utilized to operate array at array's peak power point. DET and MPS perform minute-by-minute simulation of performance of power system. Results of simulation focus mainly on output of solar array and characteristics of batteries. Both packages limited in terms of orbital mechanics, they have sufficient capability to calculate data on eclipses and performance of arrays for circular or near-circular orbits. DET and MPS written in FORTRAN-77 with some VAX FORTRAN-type extensions. Both available in three versions: GSC-13374, for DEC VAX-series computers running VMS. GSC-13443, for UNIX-based computers. GSC-13444, for Apple Macintosh computers.

Jagielski, J. M.

1994-01-01

26

Novel Mps1 kinase inhibitors: from purine to pyrrolopyrimidine and quinazoline leads.  

Science.gov (United States)

Mps1, also known as TTK, is a mitotic checkpoint protein kinase that has become a promising new target of cancer research. In an effort to improve the lead-likeness of our recent Mps1 purine lead compounds, a scaffold hopping exercise has been undertaken. Structure-based design, principles of conformational restriction, and subsequent scaffold hopping has led to novel pyrrolopyrimidine and quinazoline Mps1 inhibitors. These new single-digit nanomolar leads provide the basis for developing potent, novel Mps1 inhibitors with improved drug-like properties. PMID:24183538

Bursavich, Matthew G; Dastrup, David; Shenderovich, Mark; Yager, Kraig M; Cimbora, Daniel M; Williams, Brandi; Kumar, D Vijay

2013-12-15

27

Structural and functional characterization of the protein kinase Mps1 in Arabidopsis thaliana.  

Science.gov (United States)

In eukaryotes, protein kinases catalyze the transfer of a gamma-phosphate from ATP (or GTP) to specific amino acids in protein targets. In plants, protein kinases have been shown to participate in signaling cascades driving responses to environmental stimuli and developmental processes. Plant meristems are undifferentiated tissues that provide the major source of cells that will form organs throughout development. However, non-dividing specialized cells can also dedifferentiate and re-initiate cell division if exposed to appropriate conditions. Mps1 (Monopolar spindle) is a dual-specificity protein kinase that plays a critical role in monitoring the accuracy of chromosome segregation in the mitotic checkpoint mechanism. Although Mps1 functions have been clearly demonstrated in animals and fungi, its role in plants is so far unclear. Here, using structural and biochemical analyses here we show that Mps1 has highly similar homologs in many plant genomes across distinct lineages (e.g. AtMps1 in Arabidopsis thaliana). Several structural features (i.e. catalytic site, DFG motif and threonine triad) are clearly conserved in plant Mps1 kinases. Structural and sequence analysis also suggest that AtMps1 interact with other cell cycle proteins, such as Mad2 and MAPK1. By using a very specific Mps1 inhibitor (SP600125) we show that compromised AtMps1 activity hampers the development of A. thaliana seedlings in a dose-dependent manner, especially in secondary roots. Moreover, concomitant administration of the auxin IAA neutralizes the AtMps1 inhibition phenotype, allowing secondary root development. These observations let us to hypothesize that AtMps1 might be a downstream regulator of IAA signaling in the formation of secondary roots. Our results indicate that Mps1 might be a universal component of the Spindle Assembly Checkpoint machinery across very distant lineages of eukaryotes. PMID:23049844

de Oliveira, Eduardo Alves Gamosa; Romeiro, Nelilma Correia; Ribeiro, Elane da Silva; Santa-Catarina, Claudete; Oliveira, Antônia Elenir Amâncio; Silveira, Vanildo; de Souza Filho, Gonçalo Apolinário; Venancio, Thiago Motta; Cruz, Marco Antônio Lopes

2012-01-01

28

Phosphoregulation of human Mps1 kinase  

OpenAIRE

Abstract The dual-specificity protein kinase Mps1 is a phosphoprotein required for error-free mitotic progression in eukaryotes. In this study, we have investigated human Mps1 phosphorylation using combined mass spectrometric, mutational and phosphospecific antibody approaches. We identify sixteen sites of Mps1 autophosphorylation in vitro, several of which are required for catalytic activity after expression in bacteria or in cultured human cells. Using novel phosphospecific an...

Tyler, Rebecca K.; Chu, Matthew L. H.; Johnson, Hannah; Mckenzie, Edward A.; Gaskell, Simon J.; Eyers, Patrick A.

2008-01-01

29

Biophysical and X-ray crystallographic analysis of Mps1 kinase inhibitor complexes.  

Science.gov (United States)

The dual-specificity protein kinase monopolar spindle 1 (Mps1) is a central component of the mitotic spindle assembly checkpoint (SAC), a sensing mechanism that prevents anaphase until all chromosomes are bioriented on the metaphase plate. Partial depletion of Mps1 protein levels sensitizes transformed, but not untransformed, human cells to therapeutic doses of the anticancer agent Taxol, making it an attractive novel therapeutic cancer target. We have previously determined the X-ray structure of the catalytic domain of human Mps1 in complex with the anthrapyrazolone kinase inhibitor SP600125. In order to validate distinct inhibitors that target this enzyme and improve our understanding of nucleotide binding site architecture, we now report a biophysical and structural evaluation of the Mps1 catalytic domain in the presence of ATP and the aspecific model kinase inhibitor staurosporine. Collective in silico, enzymatic, and fluorescent screens also identified several new lead quinazoline Mps1 inhibitors, including a low-affinity compound termed Compound 4 (Cpd 4), whose interaction with the Mps1 kinase domain was further characterized by X-ray crystallography. A novel biophysical analysis demonstrated that the intrinsic fluorescence of SP600125 changed markedly upon Mps1 binding, allowing spectrophotometric displacement analysis and determination of dissociation constants for ATP-competitive Mps1 inhibitors. By illuminating the structure of the Mps1 ATP-binding site our results provide novel biophysical insights into Mps1-ligand interactions that will be useful for the development of specific Mps1 inhibitors, including those employing a therapeutically validated quinazoline template. PMID:20099905

Chu, Matthew L H; Lang, Zhaolei; Chavas, Leonard M G; Neres, João; Fedorova, Olga S; Tabernero, Lydia; Cherry, Mike; Williams, David H; Douglas, Kenneth T; Eyers, Patrick A

2010-03-01

30

Health-Related Quality of Life in Patients with MPS II.  

Science.gov (United States)

Mucopolysaccharidosis type II (MPS II), also known as Hunter syndrome, is a chronic and progressive X-linked lysosomal disease that mainly affects males. The National MPS Society (2013) reports that MPS II affects 1 in 100,000 to 1 in 150,000 males worldwide. Two distinct forms of the disease are based on age of onset and clinical course: attenuated and severe. MPS II affects many organ systems including the nervous, cardiovascular, gastrointestinal and respiratory systems. Clinical manifestations can include progressive hearing loss, mental impairment, and enlarged liver and spleen. This study focuses on the health-related quality of life of individuals (HRQOL) with MPS II as measured by the parent and self-report versions of the Pediatric Quality of Life Inventory (PedsQL™). Both parents of patients with MPS II as well as patients themselves reported lower scores on all domains of the PedsQL™ (physical, emotional, social and school functioning) indicating that children with MPS II have an overall lower HRQOL when compared to a healthy sample. When compared with patients with other chronic illnesses (cancer, MSUD, galactosemia,), the MPS II sample had significantly lower scores on a number of PedsQL™ scales, suggesting an overall lower HRQOL. No significant relationships were found using scores from parent or self report PedsQL™ measures and length of time on ERT. PMID:25395377

Needham, Mary; Packman, Wendy; Quinn, Natasha; Rappoport, Maxwell; Aoki, Christa; Bostrom, Alan; Cordova, Matthew; Macias, Sandra; Morgan, Cynthia; Packman, Seymour

2014-11-14

31

Addendum to "On the consistency of MPS"  

CERN Document Server

The analogies between the Moving Particle Semi-implicit method (MPS) and Incompressible Smoothed Particle Hydrodynamics method (ISPH) are established in this note, as an extension of the MPS consistency analysis conducted in "Souto-Iglesias et al., Computer Physics Communications, 184(3), 2013."

Souto-Iglesias, Antonio; González, Leo M; Cercos-Pita, Jose L

2013-01-01

32

Mps1p Regulates Meiotic Spindle Pole Body Duplication in Addition to Having Novel Roles during Sporulation  

OpenAIRE

Sporulation in yeast requires that a modified form of chromosome segregation be coupled to the development of a specialized cell type, a process akin to gametogenesis. Mps1p is a dual-specificity protein kinase essential for spindle pole body (SPB) duplication and required for the spindle assembly checkpoint in mitotically dividing cells. Four conditional mutant alleles of MPS1 disrupt sporulation, producing two distinct phenotypic classes. Class I alleles of mps1 ...

Straight, Paul D.; Giddings, Thomas H.; Winey, Mark

2000-01-01

33

Festo MPS -laitteiston ohjauksen toteutus Omron CP1L -logiikalla  

OpenAIRE

Työ tehtiin Oulun seudun ammattikorkeakoulun automaatiotekniikan osastolle. Osastolla on opetuskäytössä Festo MPS -laitteisto. Työssä toteutetaan MPS-laitteistoon Omron CP1L -logiikkaliitynnät, laaditaan aiheesta projektointiohje ja luodaan logiikkasovellus. Työn tarkoitus on saada MPS-laitteiston tuotantoyksiköt toimimaan Omronin logiikalla ja samalla lisätä MPS-laitteiston käyttövalmiutta eri opintojaksoilla. Työ kattaa Omron CP1L -logiikan liitäntöjen suunnittelun ja r...

Eronen, Arto

2013-01-01

34

Festo MPS PA Compact Workstation -laitteiston ohjelmointi ja käyttöliittymän tekeminen  

OpenAIRE

The purpose of this final thesis was to design a logic program and user interface for Festo MPS PA Compact Workstation, which is used for learning control systems in Seinäjoki University of Applied Sciences. Because of the limited number of lectures in a course, students do not have the time to make themselves familiar with anything but just the control systems. A programmable logic controller controls the machinery. It has integrated PID-controllers which were used to make all the diffe...

Luoma, Lauri

2011-01-01

35

MPS simulation of 2-D spontaneous dynamic rupture propagation  

Science.gov (United States)

In order to carry out numerical simulations of seismic motions, it is important to model earthquake faults. Several numerical methods have been developed for simulating spontaneous dynamic rupture on earthquake faults, obeying a certain fracture criterion or friction law. In such simulations, boundary conditions of dislocation are usually set on the fault. Traction-at-split-node (TSN) method (Andrews[1973]) is one of the most popular methods. So far, this method has introduced a boundary condition of dislocation mainly into a finite difference (FD) or a finite element (FE) method. However, the regular grid-based FD method is not so suitable for modeling "curved winding faults". The FE method can treat complex geometry, but it usually takes time to construct fine meshes suitable for keeping numerical accuracy in the complex geometry. Actually, faults in the nature are not always flat and have some complexities in geometry. In order to remedy this disadvantage, we develop a new method which introduces a boundary condition of dislocation into Moving Particle Semi-implicit (MPS) method. The MPS method, which is one of particle methods such as the SPH (Smoothed-Particle Hydrodynamics) method, was newly developed by Koshizuka and his colleagues in 1996 in order to simulate non-compressive fluid. Then, it has been applied for simulating deformation and wave propagation in elastic media since Chikazawa (1999). For instance, Takekawa et al. (2008) carried out simulation of elastic wave propagation and succeeded in simulating Hopkinson's effect. The MPS method is based on Lagrangian formulation and an elastic body is described as an aggregate of particles. The government equations for the elastic medium are interpreted into interactions among these particles. These interactions are equivalent to those of normal and tangential springs. Each particle interacts with its neighboring particles using a local weighting function. Therefore, it is quite easy to deal with heterogeneity and complex geometry. In this respect, MPS is similar to SPH. However, the MPS method applies simplified differential operator models solely based on a local weighted averaging process without taking the gradient of a kernel function, whereas the differential operators are applied to spatially weighting kernels in the SPH method. In this study, we introduced a boundary condition of "2-D curved winding faults" into a MPS method referring to the TSN method. To be specific, we set "fault particles" at both sides of the fault. In these particles, "interaction force" in the MPS method was substituted for "restoring force" in the TNS method. In addition we used a slip-dependent friction law which has a linear slip-weakening friction coefficient with a characteristic slip distance. In the presentation, we show the details of implementation of TSN on the earthquake fault into the MPS method, and discuss the feasibility and the accuracy of the MPS method for a 2-D spontaneous dynamic propagation problem.

Sakamoto, T.; Hirahara, K.

2009-12-01

36

Genetic selection for resistance to mycoplasmal pneumonia of swine (MPS) in the Landrace line influences the expression of soluble factors in blood after MPS vaccine sensitization.  

Science.gov (United States)

We recently developed a Landrace line that is resistant to mycoplasmal pneumonia of swine (MPS) infection by genetic selection for five generations, and we reported that the immunophenotype of this line is different from that of the non-selected line in terms of changes in peripheral blood leukocyte population after MPS vaccination. This study followed up previous findings demonstrating changes in soluble factors in blood, namely, hormones, Mycoplasma hyopneumoniae-specific immunoglobulin G (IgG), and cytokines. These two lines were injected with MPS vaccine on days -7 and 0 after blood sampling on those days, and blood samples were collected on days -14, -7, 0, 2, 7 and 14. We found changes in the levels of many hormones and cytokines in both lines. However, we found that only growth hormone (GH) and interferon (IFN)-? levels were statistically different between these two lines. GH concentration was reduced (day 0) and IFN-? concentration was increased (day 14) in the MPS-selected line compared with the non-selected line, despite unchanged IFN-? messenger RNA expression in blood cells. Although detailed mechanisms underlying these phenotypes remain unsolved, these traits would be useful to improve MPS resistance in pig production and provide an insight into MPS infection. PMID:24329865

Shimazu, Tomoyuki; Borjigin, Liushiqi; Katayama, Yuki; Li, Meihua; Satoh, Takumi; Watanabe, Kouichi; Kitazawa, Haruki; Roh, Sang-gun; Aso, Hisashi; Kazuo, Katoh; Suda, Yoshihito; Sakuma, Akiko; Nakajo, Mituru; Suzuki, Keiichi

2014-04-01

37

Structural and Mechanistic Insights into Mps1 Kinase Activation  

OpenAIRE

Mps1 is one of the several essential kinases whose activation is required for robust mitotic spindle checkpoint signaling. The activity of Mps1 is tightly regulated and increases dramatically during mitosis or in response to spindle damage. To understand the molecular mechanism underlying Mps1 regulation, we determined the crystal structure of the kinase domain of Mps1. The 2.7 Å resolution crystal structure shows that the Mps1 kinase domain adopts a unique inactive conformation. Intramolecu...

Wang, Wei; Yang, Yuting; Gao, Yuefeng; Xu, Quanbin; Wang, Feng; Zhu, Songcheng; Old, William; Resing, Katheryn; Ahn, Natalie; Lei, Ming; Liu, Xuedong

2009-01-01

38

MPS VAX monitor and control software architecture  

International Nuclear Information System (INIS)

The new Machine Protection System (MPS) now being tested at the SLAC Linear Collider (SLC) includes monitoring and controlling facilities integrated into the existing VAX control system. The actual machine protection is performed by VME micros which control the beam repetition rate on a pulse-by-pulse basis based on measurements from fault detectors. The VAX is used to control and configure the VME micros, configure custom CAMAC modules providing the fault detector inputs, monitor and report faults and system errors, update the SLC database, and interface with the user. The design goals of the VAX software include a database-driven system to allow configuration changes without code changes, use of a standard TCP/IP-based message service for communication, use of existing SLCNET micros for CAMAC configuration, security and verification features to prevent unauthorized access, error and alarm logging and display updates as quickly as possible, and use of touch panels and X-windows displays for the user interface

39

MPS Vax monitor and control software architecture  

International Nuclear Information System (INIS)

The new Machine Protection System (MPS) now being tested at the SLAC Linear Collider (SLC) includes monitoring and controlling facilities integrated into the existing VAX control system. The actual machine protection is performed by VME micros which control the beam repetition rate on a pulse-by-pulse basis based on measurements from fault detectors. The VAX is used to control and configure the VME micros, configure custom CAMAC modules providing the fault detector inputs, monitor and report faults and system errors, update the SLC database, and interface with the user. The design goals of the VAX software include a database-driven system to allow configuration changes without code changes, use of a standard TCP/IP-based message service for communication, use of existing SLCNET micros for CAMAC configuration, security and verification features to prevent unauthorized access, error and alarm logging and display updates as quickly as possible, and use of touch panels and X-windows displays for the user interface

40

MPS Vax monitor and control software architecture  

Energy Technology Data Exchange (ETDEWEB)

The new Machine Protection System (MPS) now being tested at the SLAC Linear Collider (SLC) includes monitoring and controlling facilities integrated into the existing VAX control system. The actual machine protection is performed by VME micros which control the beam repetition rate on a pulse-by-pulse basis based on measurements from fault detectors. The VAX is used to control and configure the VME micros, configure custom CAMAC modules providing the fault detector inputs, monitor and report faults and system errors, update the SLC database, and interface with the user. The design goals of the VAX software include a database-driven system to allow configuration changes without code changes, use of a standard TCP/IP-based message service for communication, use of existing SLCNET micros for CAMAC configuration, security and verification features to prevent unauthorized access, error and alarm logging and display updates as quickly as possible, and use of touch panels and X-windows displays for the user interface.

Allison, S.; Spencer, N.; Underwood, K.; VanOlst, D.; Zelanzy, M.

1993-04-01

41

Reversed papilledema in an MPS VI patient with galsulfase (Naglazyme®) therapy  

OpenAIRE

MPS VI (mucopolysaccharidosis VI, known as Maroteaux–Lamy syndrome) is a multi-systemic inherited disease, resulting from a deficiency of N-acetylgalactosamine-4-sulfatase, causing accumulation of the glycosaminoglycan (GAG) dermatan sulfate in all tissues. It is one of almost 50 lysosomal storage disorders. Ocular pathology is common in patients with MPS VI, with complications including ocular hypertension, progressive corneal clouding, optic nerve swelling (or papilledema) often associate...

Koseoglu, Selim T.; Harmatz, Paul; Turbeville, Sean; Nicely, Helen

2008-01-01

42

A simple algorithm to search for all d-MPs with unreliable nodes  

International Nuclear Information System (INIS)

Many real-world systems are multistate systems composed of multistate components in which the reliability can be computed in terms of the lower bound points of level d, by formulating in terms of either the d-minimal paths (d-MPs) or d-minimal cutsets (d-MCs). Such systems (electric power, transportation, etc.) may be regarded as flow networks whose arcs have independent, discrete, limited and multivalued random capacities. A simple method is proposed to search for all d-MPs for network reliability in a system subject to both arc and node failures. The proposed method does not require re-enumeration for all of the d-MPs or MPs for the additional the node failure consideration. Because only the sum of the flow through into (or from) each unreliable node of the d-MPs which found in the network with perfect nodes is calculated, the proposed algorithm is easier to understand and implement. With considering unreliable nodes, this method is also more realistic and valuable for performing the reliability analysis in an existing network. The computational complexity of the proposed algorithm is analyzed and compared with the existing methods. One example is illustrated to show how all d-MPs are generated in a network with arc and node failures solved by the proposed algorithm

43

Solution NMR of MPS-1 reveals a random coil cytosolic domain structure.  

Science.gov (United States)

Caenorhabditis elegans MPS1 is a single transmembrane helical auxiliary subunit that co-localizes with the voltage-gated potassium channel KVS1 in the nematode nervous system. MPS-1 shares high homology with KCNE (potassium voltage-gated channel subfamily E member) auxiliary subunits, and its cytosolic domain was reported to have a serine/threonine kinase activity that modulates KVS1 channel function via phosphorylation. In this study, NMR spectroscopy indicated that the full length and truncated MPS-1 cytosolic domain (134-256) in the presence or absence of n-dodecylphosphocholine detergent micelles adopted a highly flexible random coil secondary structure. In contrast, protein kinases usually adopt a stable folded conformation in order to implement substrate recognition and phosphoryl transfer. The highly flexible random coil secondary structure suggests that MPS-1 in the free state is unstructured but may require a substrate or binding partner to adopt stable structure required for serine/threonine kinase activity. PMID:25347290

Li, Pan; Shi, Pan; Lai, Chaohua; Li, Juan; Zheng, Yuanyuan; Xiong, Ying; Zhang, Longhua; Tian, Changlin

2014-01-01

44

Solution NMR of MPS-1 Reveals a Random Coil Cytosolic Domain Structure  

Science.gov (United States)

Caenorhabditis elegans MPS1 is a single transmembrane helical auxiliary subunit that co-localizes with the voltage-gated potassium channel KVS1 in the nematode nervous system. MPS-1 shares high homology with KCNE (potassium voltage-gated channel subfamily E member) auxiliary subunits, and its cytosolic domain was reported to have a serine/threonine kinase activity that modulates KVS1 channel function via phosphorylation. In this study, NMR spectroscopy indicated that the full length and truncated MPS-1 cytosolic domain (134–256) in the presence or absence of n-dodecylphosphocholine detergent micelles adopted a highly flexible random coil secondary structure. In contrast, protein kinases usually adopt a stable folded conformation in order to implement substrate recognition and phosphoryl transfer. The highly flexible random coil secondary structure suggests that MPS-1 in the free state is unstructured but may require a substrate or binding partner to adopt stable structure required for serine/threonine kinase activity. PMID:25347290

Lai, Chaohua; Li, Juan; Zheng, Yuanyuan; Xiong, Ying; Zhang, Longhua; Tian, Changlin

2014-01-01

45

Fully-automated field mapping of a dipole magnet of a multi-passage spectrometer (MPS)  

International Nuclear Information System (INIS)

MLLTRAP is a Penning-trap mass-spectrometer facility, which is currently being commissioned at the Maier-Leibnitz Laboratory in Garching. Here, atomic mass values are determined by measuring cyclotron frequencies of stored ions in a strong magnetic field. In the future, highly-charged ions should be utilized for an improvement in the achievable mass accuracy. For this purpose, singly-charged ions will have to be injected into a charge-breeding device, such as an EBIT, and transferred back towards the Penning traps, while being q/A selected. To fulfill these tasks a multi-passage-spectrometer (MPS) is being built. It consists of a fast-ramping, round-pole dipole magnet with an electrostatic mirror system. A basic requirement for building the MPS is a detailed knowledge on the magnetic field produced by the magnet. It is necessary to simulate the trajectories of the ions and gain knowledge on the design and geometry of the electrostatic mirror system and the vacuum chamber. For this purpose, a robot was designed, which - powered by three step motors - measures the magnetic field fully automated. The robot moves a Hall probe within three dimensions with a resolution of 1 mm and an uncertainty of 0.5 mm. In this presentation, the development of the robot, its control and data acquisition via LabView and the results are presented.

46

Reservoir Modeling by Data Integration via Intermediate Spaces and Artificial Intelligence Tools in MPS Simulation Frameworks  

Energy Technology Data Exchange (ETDEWEB)

Conditioning stochastic simulations are very important in many geostatistical applications that call for the introduction of nonlinear and multiple-point data in reservoir modeling. Here, a new methodology is proposed for the incorporation of different data types into multiple-point statistics (MPS) simulation frameworks. Unlike the previous techniques that call for an approximate forward model (filter) for integration of secondary data into geologically constructed models, the proposed approach develops an intermediate space where all the primary and secondary data are easily mapped onto. Definition of the intermediate space, as may be achieved via application of artificial intelligence tools like neural networks and fuzzy inference systems, eliminates the need for using filters as in previous techniques. The applicability of the proposed approach in conditioning MPS simulations to static and geologic data is verified by modeling a real example of discrete fracture networks using conventional well-log data. The training patterns are well reproduced in the realizations, while the model is also consistent with the map of secondary data.

Ahmadi, Rouhollah, E-mail: rouhollahahmadi@yahoo.com [Amirkabir University of Technology, PhD Student at Reservoir Engineering, Department of Petroleum Engineering (Iran, Islamic Republic of); Khamehchi, Ehsan [Amirkabir University of Technology, Faculty of Petroleum Engineering (Iran, Islamic Republic of)

2013-12-15

47

Reservoir Modeling by Data Integration via Intermediate Spaces and Artificial Intelligence Tools in MPS Simulation Frameworks  

International Nuclear Information System (INIS)

Conditioning stochastic simulations are very important in many geostatistical applications that call for the introduction of nonlinear and multiple-point data in reservoir modeling. Here, a new methodology is proposed for the incorporation of different data types into multiple-point statistics (MPS) simulation frameworks. Unlike the previous techniques that call for an approximate forward model (filter) for integration of secondary data into geologically constructed models, the proposed approach develops an intermediate space where all the primary and secondary data are easily mapped onto. Definition of the intermediate space, as may be achieved via application of artificial intelligence tools like neural networks and fuzzy inference systems, eliminates the need for using filters as in previous techniques. The applicability of the proposed approach in conditioning MPS simulations to static and geologic data is verified by modeling a real example of discrete fracture networks using conventional well-log data. The training patterns are well reproduced in the realizations, while the model is also consistent with the map of secondary data

48

Reducing Non-Specific Binding and Uptake of Nanoparticles and Improving Cell Targeting with an Antifouling PEO-b-P?MPS Copolymer Coating  

OpenAIRE

One of the major limitations impeding the sensitivity and specificity of biomarker targeted nanoparticles is non-specific binding by biomolecules and uptake by the reticuloendothelial system (RES). We report the development of an antibiofouling polysiloxane containing amphiphilic diblock copolymer, poly(ethylene oxide)-block-poly(?-methacryloxypropyltrimethoxysilane) (PEO-b-P?MPS), for coating and functionalizing high quality hydrophobic nanocrystals such as iron oxide nanoparticles and qua...

Chen, Hongwei; Yeh, Julie; Wang, Liya; Wu, Xinying; Cao, Zehong; Wang, Y. Andrew; Zhang, Minming; Yang, Lily; Mao, Hui

2010-01-01

49

Phosphoregulation of Spc105 by Mps1 and PP1 regulates Bub1 localization to kinetochores.  

Science.gov (United States)

Kinetochores are the macromolecular complexes that interact with microtubules to mediate chromosome segregation. Accurate segregation requires that kinetochores make bioriented attachments to microtubules from opposite poles. Attachments between kinetochores and microtubules are monitored by the spindle checkpoint, a surveillance system that prevents anaphase until every pair of chromosomes makes proper bioriented attachments. Checkpoint activity is correlated with the recruitment of checkpoint proteins to the kinetochore. Mps1 is a conserved protein kinase that regulates segregation and the spindle checkpoint, but few of the targets that mediate its functions have been identified. Here, we show that Mps1 is the major kinase activity that copurifies with budding yeast kinetochore particles and identify the conserved Spc105/KNL-1/blinkin kinetochore protein as a substrate. Phosphorylation of conserved MELT motifs within Spc105 recruits the Bub1 protein to kinetochores, and this is reversed by protein phosphatase I (PP1). Spc105 mutants lacking Mps1 phosphorylation sites are defective in the spindle checkpoint and exhibit growth defects. Together, these data identify Spc105 as a key target of the Mps1 kinase and show that the opposing activities of Mps1 and PP1 regulate the kinetochore localization of the Bub1 protein. PMID:22521787

London, Nitobe; Ceto, Steven; Ranish, Jeffrey A; Biggins, Sue

2012-05-22

50

Capturing phenotypic heterogeneity in MPS I: results of an international consensus procedure  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Mucopolysaccharidosis type I (MPS I is traditionally divided into three phenotypes: the severe Hurler (MPS I-H phenotype, the intermediate Hurler-Scheie (MPS I-H/S phenotype and the attenuated Scheie (MPS I-S phenotype. However, there are no clear criteria for delineating the different phenotypes. Because decisions about optimal treatment (enzyme replacement therapy or hematopoietic stem cell transplantation need to be made quickly and depend on the presumed phenotype, an assessment of phenotypic severity should be performed soon after diagnosis. Therefore, a numerical severity scale for classifying different MPS I phenotypes at diagnosis based on clinical signs and symptoms was developed. Methods A consensus procedure based on a combined modified Delphi method and a nominal group technique was undertaken. It consisted of two written rounds and a face-to-face meeting. Sixteen MPS I experts participated in the process. The main goal was to identify the most important indicators of phenotypic severity and include these in a numerical severity scale. The correlation between the median subjective expert MPS I rating and the scores derived from this severity scale was used as an indicator of validity. Results Full consensus was reached on six key clinical items for assessing severity: age of onset of signs and symptoms, developmental delay, joint stiffness/arthropathy/contractures, kyphosis, cardiomyopathy and large head/frontal bossing. Due to the remarkably large variability in the expert MPS I assessments, however, a reliable numerical scale could not be constructed. Because of this variability, such a scale would always result in patients whose calculated severity score differed unacceptably from the median expert severity score, which was considered to be the 'gold standard'. Conclusions Although consensus was reached on the six key items for assessing phenotypic severity in MPS I, expert opinion on phenotypic severity at diagnosis proved to be highly variable. This subjectivity emphasizes the need for validated biomarkers and improved genotype-phenotype correlations that can be incorporated into phenotypic severity assessments at diagnosis.

de Ru Minke H

2012-04-01

51

BNL multiparticle spectrometer (MPS) program  

International Nuclear Information System (INIS)

The design and operation of the BNL multiparticle spectrometer are described. Also a formation experiment anti pp ? n/sub c/ ? final state was studied at 3.7 to 4.2 GeV/c tuning the total cm energy of the anti pp system to lie near the just below the J mass to search for the existence of a narrow peak (J/sup PC/ = O/sup -+ /GAMMA? several MeV). No outstanding peak is seen, but an approximate cross section limit is given in the region of a few microbarns. There is a clear K0 signal. Also a plot of the effective mass and missing mass for events with two neutral K's produced by 8.7-GeV/c ?- on hydrogen is given

52

Phosphorylation of Mps1 by BRAFV600E prevents Mps1 degradation and contributes to chromosome instability in melanoma.  

Science.gov (United States)

Activating BRAF mutations that deregulate the mitogen-activated protein kinase (MAPK) pathway commonly occur in cancer. BRAF(V600E) induces centrosome amplification and spindle abnormalities that result in aneuploidy. We find modification of Mps1 is critical for contributing to centrosome amplification and chromosome instability induced by BRAF(V600E). Phosphorylation of Mps1 at residue S281 induced by BRAF(V600E) stabilizes Mps1 protein by preventing its ubiquitination by APC/C and subsequent degradation, allowing the non-degraded protein to accumulate at centrosomes. Cells in which endogenous Mps1 was replaced with a phospho-mimetic Mps1 mutant are viable but amplify centrosomes and missegregate chromosomes frequently. Importantly, analysis of tumor micro arrays revealed that phospho-MAPK and S281-phosphorylated Mps1 were highly correlated in human melanoma tissues, implying that MAPK contributes to defects in the degradation of Mps1 in situ. We propose that continuously activated BRAF(V600E) signaling may be a possible mechanism for the deregulation of Mps1 stability and kinase activity in human tumors, and that persistent phosphorylation of Mps1 through BRAF(V600E) signaling is a key event in disrupting the control of centrosome duplication and chromosome stability that may contribute to tumorigenesis. Our findings raise the possibility that targeting the oncogenic BRAF and S281-phosphorylated Mps1, especially when used in combination could potentially provide great therapeutic opportunities for cancer treatment. PMID:22430208

Liu, J; Cheng, X; Zhang, Y; Li, S; Cui, H; Zhang, L; Shi, R; Zhao, Z; He, C; Wang, C; Zhao, H; Zhang, C; Fisk, H A; Guadagno, T M; Cui, Y

2013-02-01

53

Spontaneous platelet aggregation in a hereditary giant platelet syndrome (MPS).  

OpenAIRE

The characteristics of spontaneous platelet aggregation (SPA) in a hereditary giant platelet syndrome (Montreal platelet syndrome, MPS) are examined. SPA was quantitated by microscopy from the decrease in single platelets in platelet-rich plasma (PRP). In contrast to normal donors, a significant proportion (20-50%) of platelets in MPS whole blood and PRP occurred in microaggregates typically containing 2-6 disk-shaped platelets. Stirring MPS-PRP at 1000 rpm for 10 minutes further increased th...

Milton, J. G.; Frojmovic, M. M.; Tang, S. S.; White, J. G.

1984-01-01

54

Antizyme Restrains Centrosome Amplification by Regulating the Accumulation of Mps1 at Centrosomes  

OpenAIRE

The failure to degrade Mps1 at centrosomes causes centrosome overproduction, but the factors that target Mps1 for degradation are unknown. This study shows that antizyme, a mediator of ubiquitin-independent degradation, binds to Mps1 and modulates centrosomal Mps1 via the proteasome, revealing a role for Mps1 in procentriole assembly.

Kasbek, Christopher; Yang, Ching-hui; Fisk, Harold A.

2010-01-01

55

Initial experience with myocardial perfusion scintigraphy (MPS) in patients awaiting lung volume reduction surgery (LVRS)  

International Nuclear Information System (INIS)

Full text: LVRS is an effective therapeutic option for patients with end-stage chronic airway limitation (CAL). Pre-operative cardiac assessment in such patients is vital for a favourable outcome. We reviewed the role of MPS in the pre-operative cardiac risk stratification of patients undergoing LVRS. Of 37 patients who underwent LVRS, 25 patients (11M/14F; mean age 59.9 yrs) were evaluated pre-operatively with a MPS. Two had a history of ischaemic heart disease. 17 patients were given dipyridamole (IV - 0.05mg/kg), and eight patients were given dobutamine (IV). The LVEF was determined in 11/25 patients (range - 54-79%, mean 65.5%). Reversible defects were reported in two patients; one involving the antero-lateral wall, confirmed with coronary catheterisation (C/C) (100% LAD lesion) and treated successfully with angioplasty, and 1 involving the inferior wall (false positive on C/C). Two fixed defects were reported, each involving the inferior wall and consistent with a history of prior inferior wall myocardial infarction. The post-operative course was favourable in all patients who had a MPS, except in one who died from sepsis, while another developed mild biventricular failure three months post-operatively. Both these patients had a normal MPS. In those who did not have a MPS study, 2/12 patients died in the post-operative period; one from sepsis (normal C/C), and the other from biventricular failure. No other cardiac complications were documented. Although the populations were documented. Although the population size was small, MPS assisted in the pre-operative cardiac risk stratification and management of patients undergoing LVRS. Copyright (2000) The Australian and New Zealand Society of Nuclear Medicine Inc

56

Indazole-based potent and cell-active Mps1 kinase inhibitors: rational design from pan-kinase inhibitor anthrapyrazolone (SP600125).  

Science.gov (United States)

Monopolar spindle 1 (Mps1) is essential for centrosome duplication, the spindle assembly check point, and the maintenance of chromosomal instability. Mps1 is highly expressed in cancer cells, and its expression levels correlate with the histological grades of cancers. Thus, selective Mps1 inhibitors offer an attractive opportunity for the development of novel cancer therapies. To design novel Mps1 inhibitors, we utilized the pan-kinase inhibitor anthrapyrazolone (4, SP600125) and its crystal structure bound to JNK1. Our design efforts led to the identification of indazole-based lead 6 with an Mps1 IC50 value of 498 nM. Optimization of the 3- and 6-positions on the indazole core of 6 resulted in 23c with improved Mps1 activity (IC50 = 3.06 nM). Finally, application of structure-based design using the X-ray structure of 23d bound to Mps1 culminated in the discovery of 32a and 32b with improved potency for cellular Mps1 and A549 lung cancer cells. Moreover, 32a and 32b exhibited reasonable selectivities over 120 and 166 kinases, respectively. PMID:23634759

Kusakabe, Ken-ichi; Ide, Nobuyuki; Daigo, Yataro; Tachibana, Yuki; Itoh, Takeshi; Yamamoto, Takahiko; Hashizume, Hiroshi; Hato, Yoshio; Higashino, Kenichi; Okano, Yousuke; Sato, Yuji; Inoue, Makiko; Iguchi, Motofumi; Kanazawa, Takayuki; Ishioka, Yukichi; Dohi, Keiji; Kido, Yasuto; Sakamoto, Shingo; Yasuo, Kazuya; Maeda, Masahiro; Higaki, Masayo; Ueda, Kazuo; Yoshizawa, Hidenori; Baba, Yoshiyasu; Shiota, Takeshi; Murai, Hitoshi; Nakamura, Yusuke

2013-06-13

57

Characterization of spindle checkpoint kinase Mps1 reveals domain with functional and structural similarities to tetratricopeptide repeat motifs of Bub1 and BubR1 checkpoint kinases.  

Science.gov (United States)

Kinetochore targeting of the mitotic kinases Bub1, BubR1, and Mps1 has been implicated in efficient execution of their functions in the spindle checkpoint, the self-monitoring system of the eukaryotic cell cycle that ensures chromosome segregation occurs with high fidelity. In all three kinases, kinetochore docking is mediated by the N-terminal region of the protein. Deletions within this region result in checkpoint failure and chromosome segregation defects. Here, we use an interdisciplinary approach that includes biophysical, biochemical, cell biological, and bioinformatics methods to study the N-terminal region of human Mps1. We report the identification of a tandem repeat of the tetratricopeptide repeat (TPR) motif in the N-terminal kinetochore binding region of Mps1, with close homology to the tandem TPR motif of Bub1 and BubR1. Phylogenetic analysis indicates that TPR Mps1 was acquired after the split between deutorostomes and protostomes, as it is distinguishable in chordates and echinoderms. Overexpression of TPR Mps1 resulted in decreased efficiency of both chromosome alignment and mitotic arrest, likely through displacement of endogenous Mps1 from the kinetochore and decreased Mps1 catalytic activity. Taken together, our multidisciplinary strategy provides new insights into the evolution, structural organization, and function of Mps1 N-terminal region. PMID:22187426

Lee, Semin; Thebault, Philippe; Freschi, Luca; Beaufils, Sylvie; Blundell, Tom L; Landry, Christian R; Bolanos-Garcia, Victor M; Elowe, Sabine

2012-02-17

58

Mps1 promotes rapid centromere accumulation of Aurora B.  

Science.gov (United States)

Aurora B localization to mitotic centromeres, which is required for proper chromosome alignment during mitosis, relies on Haspin-dependent histone H3 phosphorylation and on Bub1-dependent histone H2A phosphorylation--which interacts with Borealin through a Shugoshin (Sgo) intermediate. We demonstrate that Mps1 stimulates the latter recruitment axis. Mps1 activity enhances H2A-T120ph and is critical for Sgo1 recruitment to centromeres, thereby promoting Aurora B centromere recruitment in early mitosis. Importantly, chromosome biorientation defects caused by Mps1 inhibition are improved by restoring Aurora B centromere recruitment. As Mps1 kinetochore localization reciprocally depends on Aurora B, we propose that this Aurora B-Mps1 recruitment circuitry cooperates with the Aurora B-Haspin feedback loop to ensure rapid centromere accumulation of Aurora B at the onset of mitosis. PMID:22732840

van der Waal, Maike S; Saurin, Adrian T; Vromans, Martijn J M; Vleugel, Mathijs; Wurzenberger, Claudia; Gerlich, Daniel W; Medema, René H; Kops, Geert J P L; Lens, Susanne M A

2012-09-01

59

Characterization of novel MPS1 inhibitors with preclinical anticancer activity.  

Science.gov (United States)

Monopolar spindle 1 (MPS1), a mitotic kinase that is overexpressed in several human cancers, contributes to the alignment of chromosomes to the metaphase plate as well as to the execution of the spindle assembly checkpoint (SAC). Here, we report the identification and functional characterization of three novel inhibitors of MPS1 of two independent structural classes, N-(4-{2-[(2-cyanophenyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}phenyl)-2-phenylacetamide (Mps-BAY1) (a triazolopyridine), N-cyclopropyl-4-{8-[(2-methylpropyl)amino]-6-(quinolin-5-yl)imidazo[1,2-a]pyrazin-3-yl}benzamide (Mps-BAY2a) and N-cyclopropyl-4-{8-(isobutylamino)imidazo[1,2-a]pyrazin-3-yl}benzamide (Mps-BAY2b) (two imidazopyrazines). By selectively inactivating MPS1, these small inhibitors can arrest the proliferation of cancer cells, causing their polyploidization and/or their demise. Cancer cells treated with Mps-BAY1 or Mps-BAY2a manifested multiple signs of mitotic perturbation including inefficient chromosomal congression during metaphase, unscheduled SAC inactivation and severe anaphase defects. Videomicroscopic cell fate profiling of histone 2B-green fluorescent protein-expressing cells revealed the capacity of MPS1 inhibitors to subvert the correct timing of mitosis as they induce a premature anaphase entry in the context of misaligned metaphase plates. Hence, in the presence of MPS1 inhibitors, cells either divided in a bipolar (but often asymmetric) manner or entered one or more rounds of abortive mitoses, generating gross aneuploidy and polyploidy, respectively. In both cases, cells ultimately succumbed to the mitotic catastrophe-induced activation of the mitochondrial pathway of apoptosis. Of note, low doses of MPS1 inhibitors and paclitaxel (a microtubular poison) synergized at increasing the frequency of chromosome misalignments and missegregations in the context of SAC inactivation. This resulted in massive polyploidization followed by the activation of mitotic catastrophe. A synergistic interaction between paclitaxel and MPS1 inhibitors could also be demonstrated in vivo, as the combination of these agents efficiently reduced the growth of tumor xenografts and exerted superior antineoplastic effects compared with either compound employed alone. Altogether, these results suggest that MPS1 inhibitors may exert robust anticancer activity, either as standalone therapeutic interventions or combined with microtubule-targeting chemicals. PMID:23933817

Jemaà, M; Galluzzi, L; Kepp, O; Senovilla, L; Brands, M; Boemer, U; Koppitz, M; Lienau, P; Prechtl, S; Schulze, V; Siemeister, G; Wengner, A M; Mumberg, D; Ziegelbauer, K; Abrieu, A; Castedo, M; Vitale, I; Kroemer, G

2013-11-01

60

The Staphylococcus aureus NuoL-Like Protein MpsA Contributes to the Generation of Membrane Potential.  

Science.gov (United States)

In aerobic microorganisms, the entry point of respiratory electron transfer is represented by the NADH:quinone oxidoreductase. The enzyme couples the oxidation of NADH with the reduction of quinone. In the type 1 NADH:quinone oxidoreductase (Ndh1), this reaction is accompanied by the translocation of cations, such as H(+) or Na(+). In Escherichia coli, cation translocation is accomplished by the subunit NuoL, thus generating membrane potential (??). Some microorganisms achieve NADH oxidation by the alternative, nonelectrogenic type 2 NADH:quinone oxidoreductase (Ndh2), which is not cation translocating. Since these enzymes had not been described in Staphylococcus aureus, the goal of this study was to identify proteins operating in the NADH:quinone segment of its respiratory chain. We demonstrated that Ndh2 represents a NADH:quinone oxidoreductase in S. aureus. Additionally, we identified a hypothetical protein in S. aureus showing sequence similarity to the proton-translocating subunit NuoL of complex I in E. coli: the NuoL-like protein MpsA. Mutants with deletion of the nuoL-like gene mpsA and its corresponding operon, mpsABC (mps for membrane potential-generating system), exhibited a small-colony-variant-like phenotype and were severely affected in ?? and oxygen consumption rates. The MpsABC proteins did not confer NADH oxidation activity. Using an Na(+)/H(+) antiporter-deficient E. coli strain, we could show that MpsABC constitute a cation-translocating system capable of Na(+) transport. Our study demonstrates that MpsABC represent an important functional system of the respiratory chain of S. aureus that acts as an electrogenic unit responsible for the generation of ??. PMID:25448817

Mayer, Sonja; Steffen, Wojtek; Steuber, Julia; Götz, Friedrich

2015-03-01

61

Structural and mechanistic insights into Mps1 kinase activation  

Energy Technology Data Exchange (ETDEWEB)

Mps1 is one of the several essential kinases whose activation is required for robust mitotic spindle checkpoint signalling. The activity of Mps1 is tightly regulated and increases dramatically during mitosis or in response to spindle damage. To understand the molecular mechanism underlying Mps1 regulation, we determined the crystal structure of the kinase domain of Mps1. The 2.7-{angstrom}-resolution crystal structure shows that the Mps1 kinase domain adopts a unique inactive conformation. Intramolecular interactions between the key Glu residue in the {alpha}C helix of the N-terminal lobe and the backbone amides in the catalytic loop lock the kinase in the inactive conformation. Autophosphorylation appears to be a priming event for kinase activation. We identified Mps1 autophosphorylation sites in the activation and the P+1 loops. Whereas activation loop autophosphorylation enhances kinase activity, autophosphorylation at the P+1 loop (T686) is associated with the active kinase. Mutation of T686 autophosphorylation site impairs both autophosphorylation and transphosphorylation. Furthermore, we demonstrated that phosphorylation of T676 may be a priming event for phosphorylation at T686. Finally, we identified two critical lysine residues in the loop between helices {alpha}EF and {alpha}F that are essential for substrate recruitment and maintaining high levels of kinase activity. Our studies reveal critical biochemical mechanisms for Mps1 kinase regulation.

Wang, Wei; Yang, Yuting; Gao, Yuefeng; Xu, Quanbin; Wang, Feng; Zhu, Songcheng; Old, William; Resing, Katheryn; Ahn, Natalie; Lei, Ming; Liu, Xuedong; (Michigan); (Colorado)

2010-11-05

62

VDAC3 and Mps1 negatively regulate ciliogenesis.  

Science.gov (United States)

Centrosomes serve to organize new centrioles in cycling cells, whereas in quiescent cells they assemble primary cilia. We have recently shown that the mitochondrial porin VDAC3 is also a centrosomal protein that is predominantly associated with the mother centriole and modulates centriole assembly by recruiting Mps1 to centrosomes. Here, we show that depletion of VDAC3 causes inappropriate ciliogenesis in cycling cells, while expression of GFP-VDAC3 suppresses ciliogenesis in quiescent cells. Mps1 also negatively regulates ciliogenesis, and the inappropriate ciliogenesis caused by VDAC3 depletion can be bypassed by targeting Mps1 to centrosomes independently of VDAC3. Thus, our data show that a VDAC3-Mps1 module at the centrosome promotes ciliary disassembly during cell cycle entry and suppresses cilia assembly in proliferating cells. Our data also suggests that VDAC3 might be a link between mitochondrial dysfunction and ciliopathies in mammalian cells. PMID:23388454

Majumder, Shubhra; Fisk, Harold A

2013-03-01

63

The Multiple Roles of Mps1 in Drosophila Female Meiosis  

OpenAIRE

The Drosophila gene ald encodes the fly ortholog of mps1, a conserved kinetochore-associated protein kinase required for the meiotic and mitotic spindle assembly checkpoints. Using live imaging, we demonstrate that oocytes lacking Ald/Mps1 (hereafter referred to as Ald) protein enter anaphase I immediately upon completing spindle formation, in a fashion that does not allow sufficient time for nonexchange homologs to complete their normal partitioning to opposite half spindles. This observatio...

Gilliland, William D.; Hughes, Stacie E.; Cotitta, Jeffrey L.; Takeo, Satomi; Xiang, Youbin; Hawley, R. Scott

2007-01-01

64

Release of Mps1 from Kinetochores Is Crucial for Timely Anaphase Onset  

OpenAIRE

Mps1 kinase activity is required for proper chromosome segregation during mitosis through its involvements in microtubule–chromosome attachment error correction and the mitotic checkpoint. Mps1 dynamically exchanges on unattached kinetochores but is largely removed from kinetochores in metaphase. Here we show that Mps1 promotes its own turnover at kinetochores and that removal of Mps1 upon chromosome biorientation is a prerequisite for mitotic checkpoint silencing. Inhibition of Mps1 activi...

Jelluma, Nannette; Dansen, Tobias B.; Sliedrecht, Tale; Kops, Geert J. P. L.; Kwiatkowski, Nicholas Paul

2010-01-01

65

Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression  

OpenAIRE

The mitotic spindle is essential for the maintenance of genetic stability, and in budding yeast its assembly and function depend on the Mps1 protein kinase. Mps1p is required for centrosome duplication and the spindle checkpoint. Several recent reports demonstrate that vertebrate Mps1 proteins regulate the spindle checkpoint, but reports conflict regarding their role in centrosome duplication. Here we provide multiple lines of evidence that the human Mps1 protein (hMps1) is required for centr...

Fisk, Harold A.; Mattison, Christopher P.; Winey, Mark

2003-01-01

66

Two LXXLL motifs in the N terminus of Mps1 are required for Mps1 nuclear import during G2/M transition and sustained spindle checkpoint responses  

OpenAIRE

Spindle assembly checkpoint kinase Mps1 is spatially and temporally regulated during cell cycle progression. Mps1 is predominately localized to the cytosol in interphase cells, whereas it is concentrated on kinetochores in prophase and prometaphase cells. The timing and mechanism of Mps1 redistribution during cell cycle transition is currently poorly understood. Here, we show that Mps1 relocates from the cytosol to the nucleus at the G2/M boundary prior to nuclear envelope breakdown (NEB). Th...

Zhang, Xiaojuan; Yin, Qingqing; Ling, Youguo; Zhang, Yanhong; Ma, Runlin; Ma, Qingjun; Cao, Cheng; Zhong, Hui; Liu, Xuedong; Xu, Quanbin

2011-01-01

67

Nano-WO3 film modified macro-porous silicon (MPS) gas sensor  

International Nuclear Information System (INIS)

We prepared macro-porous silicon (MPS) by electrochemical corrosion in a double-tank cell on the surface of single-crystalline P-type silicon. Then, nano-WO3 films were deposited on MPS layers by DC facing target reactive magnetron sputtering. The morphologies of the MPS and WO3/MPS samples were investigated by using a field emission scanning electron microscope. The crystallization of WO3 and the valence of the W in the WO3/MPS sample were characterized by X-ray diffraction and X-ray photoelectron spectroscopy, respectively. The gas sensing properties of MPS and WO3/MPS gas sensors were thoroughly measured at room temperature. It can be concluded that: the WO3/MPS gas sensor shows the gas sensing properties of a P-type semiconductor gas sensor. The WO3/MPS gas sensor exhibits good recovery characteristics and repeatability to 1 ppm NO2. The addition of WO3 can enhance the sensitivity of MPS to NO2. The long-term stability of a WO3/MPS gas sensor is better than that of an MPS gas sensor. The sensitivity of the WO3/MPS gas sensor to NO2 is higher than that to NH3 and C2H5OH. The selectivity of the MPS to NO2 is modified by deposited nano-WO3 film. (semiconductor devices)

68

Overexpression of Mps1 in colon cancer cells attenuates the spindle assembly checkpoint and increases aneuploidy.  

Science.gov (United States)

The spindle assembly checkpoint kinase Mps1 is highly expressed in several types of cancers, but its cellular involvement in tumorigenesis is less defined. Herein, we confirm that Mps1 is overexpressed in colon cancer tissues. Further, we find that forced expression of Mps1 in the colon cancer cell line SW480 enables cells to become resistant to both Mps1 inhibition-induced checkpoint depletion and cell death. Overexpression of Mps1 also increases genome instability in tumor cells owing to a weakened spindle assembly checkpoint. Collectively, our findings suggest that high levels of Mps1 contribute to tumorigenesis by attenuating the spindle assembly checkpoint. PMID:25063032

Ling, Youguo; Zhang, Xiaojuan; Bai, Yuanyuan; Li, Ping; Wei, Congwen; Song, Ting; Zheng, Zirui; Guan, Kai; Zhang, Yanhong; Zhang, Buchang; Liu, Xuedong; Ma, Runlin Z; Cao, Cheng; Zhong, Hui; Xu, Quanbin

2014-08-01

69

Cellular Abundance of Mps1 and the Role of Its Carboxyl Terminal Tail in Substrate Recruitment*  

OpenAIRE

Mps1 is a protein kinase that regulates normal mitotic progression and the spindle checkpoint in response to spindle damage. The levels of Mps1 are relatively low in cells during interphase but elevated in mitosis or upon activation of the spindle checkpoint, although the dynamic range of Mps1 expression and the Mps1 catalytic mechanism have not been carefully characterized. Our recent structural studies of the Mps1 kinase domain revealed that the carboxyl-terminal tail region of Mps1 is unst...

Sun, Tingting; Yang, Xiaomei; Wang, Wei; Zhang, Xiaojuan; Xu, Quanbin; Zhu, Songcheng; Kuchta, Robert; Chen, Guanjun; Liu, Xuedong

2010-01-01

70

Expert recommendations for the laboratory diagnosis of MPS VI.  

Science.gov (United States)

Mucopolysaccharidosis VI (MPS VI) is a lysosomal storage disease caused by a deficiency of N-acetylgalactosamine 4-sulfatase (arylsulfatase B, ASB). This enzyme is required for the degradation of dermatan sulfate. In its absence, dermatan sulfate accumulates in cells and is excreted in large quantities in urine. Specific therapeutic intervention is available; however, accurate and timely diagnosis is crucial for maximal benefit. To better understand the current practices for diagnosis and to establish diagnostic guidelines, an international MPS VI laboratory diagnostics scientific summit was held in February of 2011 in Miami, Florida. The various steps in the diagnosis of MPS VI were discussed including urinary glycosaminoglycan (uGAG) analysis, enzyme activity analysis, and molecular analysis. The following conclusions were reached. Dilute urine samples pose a significant problem for uGAG analysis and MPS VI patients can be missed by quantitative uGAG testing alone as dermatan sulfate may not always be excreted in large quantities. Enzyme activity analysis is universally acknowledged as a key component of diagnosis; however, several caveats must be considered and the appropriate use of reference enzymes is essential. Molecular analysis supports enzyme activity test results and is essential for carrier testing, subsequent genetic counseling, and prenatal testing. Overall the expert panel recommends caution in the use of uGAG screening alone to rule out or confirm the diagnosis of MPS VI and acknowledges enzyme activity analysis as a critical component of diagnosis. Measurement of another sulfatase enzyme to exclude multiple sulfatase deficiency was recommended prior to the initiation of therapy. When feasible, the use of molecular testing as part of the diagnosis is encouraged. A diagnostic algorithm for MPS VI is provided. PMID:22405600

Wood, T; Bodamer, O A; Burin, M G; D'Almeida, V; Fietz, M; Giugliani, R; Hawley, S M; Hendriksz, C J; Hwu, W L; Ketteridge, D; Lukacs, Z; Mendelsohn, N J; Miller, N; Pasquali, M; Schenone, A; Schoonderwoerd, K; Winchester, B; Harmatz, P

2012-05-01

71

Two LXXLL motifs in the N terminus of Mps1 are required for Mps1 nuclear import during G(2)/M transition and sustained spindle checkpoint responses.  

Science.gov (United States)

Spindle assembly checkpoint kinase Mps1 is spatially and temporally regulated during cell cycle progression. Mps1 is predominately localized to the cytosol in interphase cells, whereas it is concentrated on kinetochores in prophase and prometaphase cells. The timing and mechanism of Mps1 redistribution during cell cycle transition is currently poorly understood. Here, we show that Mps1 relocates from the cytosol to the nucleus at the G 2/M boundary prior to nuclear envelope breakdown (NEB). This timely translocation depends on two tandem LXXLL motifs in the N terminus of Mps1, and mutations in either motif abolish Mps1 nuclear accumulation. Furthermore, we found that phosphorylation of Mps1 Ser80 (which is located between the two LXXLL motifs) also plays a role in regulating timely nuclear entry of Mps1. Mps1 that is defective in LXXLL motifs has near wild-type kinase activity. Moreover, the kinase activity of Mps1 appears to be dispensable for nuclear translocation, as inhibition of Mps1 by a highly specific small-molecule inhibitor did not perturb its nuclear entry. Remarkably, translocation-deficient Mps1 can mediate activation of spindle assembly checkpoint response; however, it fails to support a sustained mitotic arrest upon prolonged treatment with nocodazole. The mitotic slippage can be attributed to precocious degradation of Mps1 in the arrested cells. Our studies reveal a novel cell cycle-dependent nuclear translocation signal in the N terminus of Mps1 and suggest that timely nuclear entry could be important for sustaining spindle assembly checkpoint responses. PMID:21778823

Zhang, Xiaojuan; Yin, Qingqing; Ling, Youguo; Zhang, Yanhong; Ma, Runlin; Ma, Qingjun; Cao, Cheng; Zhong, Hui; Liu, Xuedong; Xu, Quanbin

2011-08-15

72

Mps1 kinase activity restrains anaphase during an unperturbed mitosis and targets Mad2 to kinetochores  

OpenAIRE

Mps1 is an upstream component of the spindle assembly checkpoint, which, in human cells, is required for checkpoint activation in response to spindle damage but not apparently during an unperturbed mitosis. Mps1 also recruits Mad1 and Mad2 to kinetochores. However, whether the enzymatic activity of Mps1 is required for these processes is unclear. To address this question, we established an RNA interference (RNAi) complementation assay. Repression of Mps1 triggers premature anaphase, often wit...

Tighe, Anthony; Staples, Oliver; Taylor, Stephen

2008-01-01

73

Mps1 Phosphorylation Sites Regulate the Function of Centrin 2 in Centriole Assembly  

OpenAIRE

We show that while Centrin2 is dispensable for centriole assembly, it is an Mps1 substrate that stimulates canonical and aberrant centriole assembly by two different Mps1-dependent mechanisms, HsSas-6–dependent and –independent. Centrin2 phosphorylation is also required for the ability of Mps1 to drive production of mature centrioles.

Yang, Ching-hui; Kasbek, Christopher; Majumder, Shubhra; Yusof, Adlina Mohd; Fisk, Harold A.

2010-01-01

74

A preliminary design proposal for a maritime patrol strike aircraft: MPS-2000 Condor  

Science.gov (United States)

The four member graduate design team assembled to submit a proposal for the 1993/1994 RFP at the University of Kansas has designed a four seat, variable swept wing, twin turbofan aircraft with STOL capabilities. The aircraft is named the MPS-2000 Condor and is capable of carrying air-to-surface or air-to-air weapon systems along with attack and surveillance radar and IRF systems. The aircraft has a cruise range of 800 nautical miles, a loiter of 4 hours, and a dash speed of 500 kts.

1994-01-01

75

VDAC3 regulates centriole assembly by targeting Mps1 to centrosomes.  

Science.gov (United States)

Centrioles are duplicated during S-phase to generate the two centrosomes that serve as mitotic spindle poles during mitosis. The centrosomal pool of the Mps1 kinase is important for centriole assembly, but how Mps1 is delivered to centrosomes is unknown. Here we have identified a centrosome localization domain within Mps1 and identified the mitochondrial porin VDAC3 as a protein that binds to this region of Mps1. Moreover, we show that VDAC3 is present at the mother centriole and modulates centriole assembly by recruiting Mps1 to centrosomes. PMID:22935710

Majumder, Shubhra; Slabodnick, Mark; Pike, Amanda; Marquardt, Joseph; Fisk, Harold A

2012-10-01

76

New Alleles of the Yeast MPS1 Gene Reveal Multiple Requirements in Spindle Pole Body Duplication  

OpenAIRE

In Saccharomyces cerevisiae, the Mps1p protein kinase is critical for both spindle pole body (SPB) duplication and the mitotic spindle assembly checkpoint. The mps1–1 mutation causes failure early in SPB duplication, and because the spindle assembly checkpoint is also compromised, mps1–1 cells proceed with a monopolar mitosis and rapidly lose viability. Here we report the genetic and molecular characterization of mps1–1 and five new temperature-sensitive alleles of MPS1. Each of the six...

Schutz, Amy R.; Winey, Mark

1998-01-01

77

Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication  

OpenAIRE

Budding yeast Mps1p kinase has been implicated in both the duplication of microtubule-organizing centers and the spindle assembly checkpoint. Here we show that hMps1, the human homolog of yeast Mps1p, is a cell cycle-regulated kinase with maximal activity during M phase. hMps1 localizes to kinetochores and its activity and phosphorylation state increase upon activation of the mitotic checkpoint. By antibody microinjection and siRNA, we demonstrate that hMps1 is required for human cells to und...

Stucke, Volker M.; Sillje?, Herman H. W.; Arnaud, Lionel; Nigg, Erich A.

2002-01-01

78

Preclinical dose ranging studies for enzyme replacement therapy with idursulfase in a knock-out mouse model of MPS II.  

Science.gov (United States)

Mucopolysaccharidosis II (MPS II; Hunter syndrome) is an X-linked metabolic disorder caused by a deficiency of the lysosomal enzyme iduronate-2-sulfatase (I2S), which catalyzes the catabolism of glycosaminoglycans (GAG) by cleaving the O-linked sulfate from dermatan sulfate and heparan sulfate. Recently, enzyme replacement therapy (ERT) with recombinant human I2S (Elaprase (idursulfase), Shire Human Genetic Therapies, Inc.), has been approved in the US and European Union for the treatment and management of MPS II. The purpose of the studies presented here was to describe some of the preclinical development of idursulfase using the I2S knock-out mouse model of MPS II designed to study the effect of dose and various dosing regimens of idursulfase on urine and tissue GAG levels. Urine and tissue samples were collected prior to idursulfase treatment and periodically throughout each study and analyzed for GAGs. The presence of anti-idursulfase antibodies in the mice serum after idursulfase use was also determined. Results showed that idursulfase, at several doses and at several dosing frequencies, caused a reduction in tissue and urine GAG levels in a dose-dependent manner. These studies also demonstrated that after IV administration, idursulfase is biologically active in the IdS-KO mouse model and is transported to key target tissues, reaching the lysosomes in an active form, and degrading the accumulated GAG. In conclusion, these results indicated that ERT with idursulfase produced in a human cell line could be useful in the treatment and management of MPS II, and were used in the design of clinical studies to evaluate the efficacy of idursulfase in MPS II patients. PMID:17459751

Garcia, Antony R; DaCosta, Jeffrey M; Pan, Jing; Muenzer, Joseph; Lamsa, Justin C

2007-06-01

79

Role of mps1 map kinase signalling patwahy in fungal pathogenicity and cell wall integrity  

OpenAIRE

The cell wall integrity is crucial for the survival of fungi during its development or in reaction in stress conditions. In yeast, the MAP kinase pathway Slt2, and the calcineurin pathway are responsible of the cell wall repair. MPS1, the orthologous of SLT2, in Magnaporthe grisea is essential for the repair of the cell wall and the penetration of the appressorium (Xu, and Al, 1998). In yeast, Slt2 activates the transcription factors Rlm1, Swi4 and Swi6, whereas the calcineurin activates Crz1...

Ant, Cemile

2011-01-01

80

TP53 mutation-correlated genes predict the risk of tumor relapse and identify MPS1 as a potential therapeutic kinase in TP53-mutated breast cancers.  

Science.gov (United States)

Breast cancers (BC) carry a complex set of gene mutations that can influence their gene expression and clinical behavior. We aimed to identify genes driven by the TP53 mutation status and assess their clinical relevance in estrogen receptor (ER)-positive and ER-negative BC, and their potential as targets for patients with TP53 mutated tumors. Separate ROC analyses of each gene expression according to TP53 mutation status were performed. The prognostic value of genes with the highest AUC were assessed in a large dataset of untreated, and neoadjuvant chemotherapy treated patients. The mitotic checkpoint gene MPS1 was the most significant gene correlated with TP53 status, and the most significant prognostic marker in all ER-positive BC datasets. MPS1 retained its prognostic value independently from the type of treatment administered. The biological functions of MPS1 were investigated in different BC cell lines. We also assessed the effects of a potent small molecule inhibitor of MPS1, SP600125, alone and in combination with chemotherapy. Consistent with the gene expression profiling and siRNA assays, the inhibition of MPS1 by SP600125 led to a reduction in cell viability and a significant increase in cell death, selectively in TP53-mutated BC cells. Furthermore, the chemical inhibition of MPS1 sensitized BC cells to conventional chemotherapy, particularly taxanes. Our results collectively demonstrate that TP53-correlated kinase MPS1, is a potential therapeutic target in BC patients with TP53 mutated tumors, and that SP600125 warrant further development in future clinical trials. PMID:24462521

Gy?rffy, Balázs; Bottai, Giulia; Lehmann-Che, Jacqueline; Kéri, György; Orfi, László; Iwamoto, Takayuki; Desmedt, Christine; Bianchini, Giampaolo; Turner, Nicholas C; de Thè, Hugues; André, Fabrice; Sotiriou, Christos; Hortobagyi, Gabriel N; Di Leo, Angelo; Pusztai, Lajos; Santarpia, Libero

2014-05-01

81

Immunological characterization of peripheral blood leukocytes using vaccine for mycoplasmal pneumonia of swine (MPS) in swine line selected for resistance to MPS.  

Science.gov (United States)

This study was conducted to evaluate immunological changes in peripheral blood leukocytes in pigs that were genetically selected for their improved resistance to mycoplasmal pneumonia of swine (MPS), using MPS vaccine as an antigen. Twelve castrated MPS-selected Landrace pigs were compared with the same number of pigs from a nonselected line by using a time-course analysis at the hematological level. After the second sensitization with MPS vaccine, the percentages of B cells, CD4(+) T cells, and natural killer (NK) cells in total leukocytes were lower in the selected line than in the nonselected line, whereas the percentage of granulocytes in total leukocytes increased in the MPS-selected line. We also assessed the proliferative ability of peripheral blood mononuclear cells (PBMCs) stimulated with Mycoplasma hyopneumoniae, lipopolysaccharide or concanavalin A, and found that although the proliferative ability of the PBMC was not different between the two lines at a steady state, the nonselected line showed a significantly higher proliferative ability after sensitization with MPS vaccine than the selected line regardless of antigens used. These results thus indicate that the selection of pigs on the basis of MPS resistance changes their immunophenotype, and would give us beneficial information for the prevention of MPS infection. PMID:23607374

Shimazu, Tomoyuki; Borjigin, Liushiqi; Katayama, Yuki; Li, Meihua; Satoh, Takumi; Watanabe, Kouichi; Kitazawa, Haruki; Roh, Sang-gun; Aso, Hisashi; Katoh, Kazuo; Suda, Yoshihito; Sakuma, Akiko; Nakajo, Mituru; Suzuki, Keiichi

2013-10-01

82

Operation of the Brookhaven MPS II Facility  

International Nuclear Information System (INIS)

The BNL Multiparticle Spectrometer has recently been equipped with a set of narrow cell drift chambers employing a novel, compact, inexpensive, readout scheme. This has given an order of magnitude improvement in beam rate as well as better spatial resolution. Two experiments have been completed in the first year of operation, a good test of the system. This type of a drift chamber arrangement is ideal for use at high luminosity hadron colliders

83

MPS on the Hunt for Planets  

CERN Document Server

Planetary systems toward the Galactic Bulge can be detected through microlensing measurements. The microlensing planet search technique has some unique merits: low-mass planets can be detected from the ground; the Galactic family of planetary systems can be sampled unbiased; the time scale for the completion of each event is relatively short. The unambiguity of the underlying low-multiplicity point lenses is an indispensable element that allows robust interpretaion of the events. We have found the first circumbinary planet in the microlensing event MACHO-97-BLG-41. We have found evidence of a low mass planet (few Earths to Neptune mass) in a very high magnification event MACHO-98-BLG-35. We emphasize the necessity for coherent searches of microlensing planets with a network of instruments in the southern hemisphere. The network can also be vitally instrumental for follow-up observations of SN1a's and GRB's which share with microlensing planets the transiency as well as the clues to our quest of the origins.

Rhie, S H

1999-01-01

84

MRI morphometric characterisation of the paediatric cervical spine and spinal cord in children with MPS IVA (Morquio-Brailsford syndrome)  

OpenAIRE

Nearly all children with MPS IVA develop skeletal deformities affecting the spine. At the atlanto-axial spine, odontoid hypoplasia occurs. GAG deposition around the dens, leads to peri-odontoid infiltration. Transverse/alar ligament incompetence causes instability. Atlanto-axial instability is associated with cord compression and myelopathy, leading to major morbidity and mortality. Intervention is often required. Does the presence of widened bullet shaped vertebra in platyspondily encroach o...

Solanki, Guirish A.; Lo, William B.; Hendriksz, Christian J.

2013-01-01

85

Contingent Information Systems Development  

OpenAIRE

Situated approaches based on project contingencies are becoming more and more an important research topic for information systems development organizations. The Information Services Organization, which was investigated, has recognized that it should tune its systems development approaches to the specific situation. A model has been developed, dealing with the matching between prevailing contingency factors and the preconditions of already existing situated approaches. Furthermore, a generic p...

Slooten, Kees; Schoonhoven, Bram

1996-01-01

86

Heterologous Expression and Purification Systems for Structural Proteomics of Mammalian Membrane Proteins  

Directory of Open Access Journals (Sweden)

Full Text Available Membrane proteins (MPs are responsible for the interface between the exterior and the interior of the cell. These proteins are implicated in numerous diseases, such as cancer, cystic fibrosis, epilepsy, hyperinsulinism, heart failure, hypertension and Alzheimer's disease. However, studies on these disorders are hampered by a lack of structural information about the proteins involved. Structural analysis requires large quantities of pure and active proteins. The majority of medically and pharmaceutically relevant MPs are present in tissues at very low concentration, which makes heterologous expression in large-scale production-adapted cells a prerequisite for structural studies. Obtaining mammalian MP structural data depends on the development of methods that allow the production of large quantities of MPs. This review focuses on the different heterologous expression systems, and the purification strategies, used to produce large amounts of pure mammalian MPs for structural proteomics.

Isabelle Mus-Veteau

2006-04-01

87

Cascade Distillation System Development  

Science.gov (United States)

NASA's Advanced Exploration Systems (AES) Life Support System (LSS) Project is chartered with de-veloping advanced life support systems that will ena-ble NASA human exploration beyond low Earth orbit (LEO). The goal of AES is to increase the affordabil-ity of long-duration life support missions, and to re-duce the risk associated with integrating and infusing new enabling technologies required to ensure mission success. Because of the robust nature of distillation systems, the AES LSS Project is pursuing develop-ment of the Cascade Distillation Subsystem (CDS) as part of its technology portfolio. Currently, the system is being developed into a flight forward Generation 2.0 design.

Callahan, Michael R.; Sargushingh, Miriam; Shull, Sarah

2014-01-01

88

Development of a machine protection system for the Superconducting Beam Test Facility at Fermilab  

International Nuclear Information System (INIS)

Fermilab's Superconducting RF Beam Test Facility currently under construction will produce electron beams capable of damaging the acceleration structures and the beam line vacuum chambers in the event of an aberrant accelerator pulse. The accelerator is being designed with the capability to operate with up to 3000 bunches per macro-pulse, 5Hz repetition rate and 1.5 GeV beam energy. It will be able to sustain an average beam power of 72 KW at the bunch charge of 3.2 nC. Operation at full intensity will deposit enough energy in niobium material to approach the melting point of 2500 C. In the early phase with only 3 cryomodules installed the facility will be capable of generating electron beam energies of 810 MeV and an average beam power that approaches 40 KW. In either case a robust Machine Protection System (MPS) is required to mitigate effects due to such large damage potentials. This paper will describe the MPS system being developed, the system requirements and the controls issues under consideration.

89

Development of a machine protection system for the Superconducting Beam Test Facility at Fermilab  

Energy Technology Data Exchange (ETDEWEB)

Fermilab's Superconducting RF Beam Test Facility currently under construction will produce electron beams capable of damaging the acceleration structures and the beam line vacuum chambers in the event of an aberrant accelerator pulse. The accelerator is being designed with the capability to operate with up to 3000 bunches per macro-pulse, 5Hz repetition rate and 1.5 GeV beam energy. It will be able to sustain an average beam power of 72 KW at the bunch charge of 3.2 nC. Operation at full intensity will deposit enough energy in niobium material to approach the melting point of 2500 C. In the early phase with only 3 cryomodules installed the facility will be capable of generating electron beam energies of 810 MeV and an average beam power that approaches 40 KW. In either case a robust Machine Protection System (MPS) is required to mitigate effects due to such large damage potentials. This paper will describe the MPS system being developed, the system requirements and the controls issues under consideration.

Warner, A.; Carmichael, L.; Church, M.; Neswold, R.; /Fermilab

2011-09-01

90

Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis  

OpenAIRE

The mitotic checkpoint prevents mitotic exit until all chromosomes are attached to spindle microtubules. Aurora B kinase indirectly invokes this checkpoint by destabilizing incorrect attachments; however, a more direct role remains controversial. In contrast, activity of the kinase Mps1 is indispensible for the mitotic checkpoint. Here we show that Aurora B and Hec1 are needed for efficient Mps1 recruitment to unattached kinetochores, allowing rapid Mps1 activation at the onset of mitosis. Li...

Saurin, Adrian T.; Waal, Maike S.; Medema, Rene? H.; Lens, Susanne M. A.; Kops, Geert J. P. L.

2011-01-01

91

Regulation of Kinetochore Recruitment of Two Essential Mitotic Spindle Checkpoint Proteins by Mps1 Phosphorylation  

OpenAIRE

Mps1 is a protein kinase that plays essential roles in spindle checkpoint signaling. Unattached kinetochores or lack of tension triggers recruitment of several key spindle checkpoint proteins to the kinetochore, which delays anaphase onset until proper attachment or tension is reestablished. Mps1 acts upstream in the spindle checkpoint signaling cascade, and kinetochore targeting of Mps1 is required for subsequent recruitment of Mad1 and Mad2 to the kinetochore. The mechanisms that govern rec...

Xu, Quanbin; Zhu, Songcheng; Wang, Wei; Zhang, Xiaojuan; Old, William; Ahn, Natalie; Liu, Xuedong

2009-01-01

92

Spindle checkpoint-independent inhibition of mitotic chromosome segregation by Drosophila Mps1  

OpenAIRE

Monopolar spindle 1 (Mps1) is essential for the spindle assembly checkpoint (SAC), which prevents anaphase onset in the presence of misaligned chromosomes. Moreover, Mps1 kinase contributes in a SAC-independent manner to the correction of erroneous initial attachments of chromosomes to the spindle. Our characterization of the Drosophila homologue reveals yet another SAC-independent role. As in yeast, modest overexpression of Drosophila Mps1 is sufficient to delay progression through mitosis d...

Althoff, F.; Karess, R. E.; Lehner, C. F.

2012-01-01

93

Die humane Proteinkinase Mps1 ist essentiell für den mitotischen Spindelkontrollpunkt, aber nicht für Zentrosomenduplikation  

OpenAIRE

Die Familie der Mps1-Proteinkinasen (Monopolar spindle 1) hat mehrere wichtige Aufgaben im Zellzyklus. Mps1p wurde zuerst in S. cerevisiae gefunden und näher charakterisiert. Mps1p ist zum einen an der Verdoppelung des Spindel-Polkörperchens beteiligt und zum anderen ist die Kinase eine Komponente im mitotischen Spindelkontrollpunkt. Das Spindel-Polkörperchen ist das Centrosomäquivalent in Hefezellen und somit das Mikrotubuli-Organisationszentrum (MTOC) in Zellen. Zu Beginn der Mitose die...

Stucke, Volker Matthias

2003-01-01

94

High levels of the Mps1 checkpoint protein are protective of aneuploidy in breast cancer cells  

OpenAIRE

Most human cancers are aneuploid and have chromosomal instability, which contrasts to the inability of human cells to normally tolerate aneuploidy. Noting that aneuploidy in human breast cancer correlates with increased expression levels of the Mps1 checkpoint gene, we investigated whether these high levels of Mps1 contribute to the ability of breast cancer cells to tolerate this aneuploidy. Reducing Mps1 levels in cultured human breast cancer cells by RNAi resulted in aberrant mitoses, induc...

Daniel, Jewel; Coulter, Jonathan; Woo, Ju-hyung; Wilsbach, Kathleen; Gabrielson, Edward

2011-01-01

95

Injection of recombinant human sulfamidase into the CSF via the cerebellomedullary cistern in MPS IIIA mice.  

Science.gov (United States)

At present, there is no widely available, safe and effective treatment for lysosomal storage disorders (LSD) that affect the brain. We have used a naturally occurring mouse model of mucopolysaccharidosis type IIIA (MPS IIIA) or Sanfilippo syndrome, to evaluate the effect of repeated injection of recombinant human sulfamidase (rhSGSH) into the cerebrospinal fluid via the cisterna magna (CM) on central nervous system (CNS) pathology and behavioral function. Mice received up to seven injections of rhSGSH (5-20 microg rhSGSH per injection) or vehicle on a fortnightly or monthly basis. A dose-dependent reduction in the level of a heparan sulfate-derived monosulfated disaccharide was observed within the brain (up to 62% reduction compared with vehicle-treated MPS IIIA mice) and spinal cord (up to 71% reduction). Ultrastructural examination revealed a reduction in lysosomal vesicle formation in various cell types and fewer (ubiquitin-positive) axonal spheroids were observed in several brain regions. The biochemical changes were accompanied by improved behavior, particularly in mice-treated more frequently. A humoral immune response to rhSGSH was observed in treated animals. Intra-CM injection of lysosomal enzyme may therefore represent an immediately applicable method of treating the CNS effects of this and potentially other LSD that affect the brain. PMID:17166757

Hemsley, Kim M; King, Barbara; Hopwood, John J

2007-03-01

96

Evaluation of enzyme dose and dose-frequency in ameliorating substrate accumulation in MPS IIIA Huntaway dog brain.  

Science.gov (United States)

Intracerebrospinal fluid (CSF) infusion of replacement enzyme is under evaluation for amelioration of disease-related symptoms and biomarker changes in patients with the lysosomal storage disorder mucopolysaccharidosis type IIIA (MPS IIIA; www.clinicaltrials.gov ; NCT#01155778; #01299727). Determining the optimal dose/dose-frequency is important, given the invasive method for chronically supplying recombinant protein to the brain, the main site of symptom generation. To examine these variables, we utilised MPS IIIA Huntaway dogs, providing recombinant human sulphamidase (rhSGSH) to young pre-symptomatic dogs from an age when MPS IIIA dog brain exhibits significant accumulation of primary (heparan sulphate) and secondary (glycolipid) substrates. Enzyme was infused into CSF via the cisterna magna at one of two doses (3 mg or 15 mg/infusion), with the higher dose supplied at two different intervals; fortnightly or monthly. Euthanasia was carried out 24 h after the final injection. Dose- and frequency-dependent reductions in heparan sulphate were observed in CSF and deeper layers of cerebral cortex. When we examined the amount of immunostaining of the general endo/lysosomal marker, LIMP-2, or quantified activated microglia, the higher fortnightly dose resulted in superior outcomes in affected dogs. Secondary lesions such as accumulation of GM3 ganglioside and development of GAD-reactive axonal spheroids were treated to a similar degree by both rhSGSH doses and dose frequencies. Our findings indicate that the lower fortnightly dose is sub-optimal for ameliorating existing and preventing further development of disease-related pathology in young MPS IIIA dog brain; however, increasing the dose fivefold but halving the frequency of administration enabled near normalisation of disease-related biomarkers. PMID:25421091

King, Barbara; Marshall, Neil; Beard, Helen; Hassiotis, Sofia; Trim, Paul J; Snel, Marten F; Rozaklis, Tina; Jolly, Robert D; Hopwood, John J; Hemsley, Kim M

2014-11-25

97

CDK-dependent potentiation of MPS1 kinase activity is essential to the mitotic checkpoint.  

Science.gov (United States)

Accurate chromosome segregation relies upon a mitotic checkpoint that monitors kinetochore attachment toward opposite spindle poles before enabling chromosome disjunction [1]. The MPS1/TTK protein kinase is a core component of the mitotic checkpoint that lies upstream of MAD2 and BubR1 both at the kinetochore and in the cytoplasm [2, 3]. To gain insight into the mechanisms underlying the regulation of MPS1 kinase, we undertook the identification of Xenopus MPS1 phosphorylation sites by mass spectrometry. We mapped several phosphorylation sites onto MPS1 and we show that phosphorylation of S283 in the noncatalytic region of MPS1 is required for full kinase activity. This phosphorylation potentiates MPS1 catalytic efficiency without impairing its affinity for the substrates. By using Xenopus egg extracts depleted of endogenous MPS1 and reconstituted with single point mutants, we show that phosphorylation of S283 is essential to activate the mitotic checkpoint. This phosphorylation does not regulate the localization of MPS1 to the kinetochore but is required for the recruitment of MAD1/MAD2, demonstrating its role at the kinetochore. Constitutive phosphorylation of S283 lowers the number of kinetochores required to hold the checkpoint, which suggests that CDK-dependent phosphorylation of MPS1 is essential to sustain the mitotic checkpoint when few kinetochores remain unattached. PMID:22245000

Morin, Violeta; Prieto, Susana; Melines, Sabrina; Hem, Sonia; Rossignol, Michel; Lorca, Thierry; Espeut, Julien; Morin, Nathalie; Abrieu, Ariane

2012-02-21

98

Autophosphorylation-dependent activation of human Mps1 is required for the spindle checkpoint  

OpenAIRE

The spindle checkpoint ensures the accuracy of chromosome segregation during mitosis. The protein serine/threonine kinase, Mps1, is a critical component of the spindle checkpoint in human cells and regulates the kinetochore localization of key checkpoint proteins. The kinase activity of Mps1 is required for the spindle checkpoint, but how Mps1 is activated during mitosis is unclear. Here, we show that the endogenous Mps1 in mitotic HeLa cells is phosphorylated on T676, a residue in the activa...

Kang, Jungseog; Chen, Yue; Zhao, Yingming; Yu, Hongtao

2007-01-01

99

Mip1 associates with both the Mps1 kinase and actin and is required for cell cortex stability and anaphase spindle positioning  

Science.gov (United States)

The Mps1 family of protein kinases contributes to cell cycle control by regulating multiple microtubule cytoskeleton activities. We have uncovered a new Mps1 substrate that provides a novel link between Mps1 and the actin cytoskeleton. We have identified a conserved human Mps1 (hMps1) interacting pr...

100

Evolutionary Information System Development  

DEFF Research Database (Denmark)

This paper offers advice to companies and professionals that implement e-commerce systems in business organizations. Implementing e-commerce systems is different from traditional IT implementation and thus requires a new set of tools and skills. The need for a novel approach is illustrated and necessary items that must be taken into account are pointed out by narrating two stories of e-commerce implementation processes in wholesale companies. The empirical evidence suggests the following: Managing the continued development on an operational level requires operational insight and understanding of business priorities. On a more theoretical level this suggests that we must revise our current understanding of systems development to cope.

Kristensen, Jan

101

Power Systems Development Facility  

Energy Technology Data Exchange (ETDEWEB)

In support of technology development to utilize coal for efficient, affordable, and environmentally clean power generation, the Power Systems Development Facility (PSDF), located in Wilsonville, Alabama, has routinely demonstrated gasification technologies using various types of coals. The PSDF is an engineering scale demonstration of key features of advanced coal-fired power systems, including a Transport Gasifier, a hot gas particulate control device, advanced syngas cleanup systems, and high-pressure solids handling systems. This final report summarizes the results of the technology development work conducted at the PSDF through January 31, 2009. Twenty-one major gasification test campaigns were completed, for a total of more than 11,000 hours of gasification operation. This operational experience has led to significant advancements in gasification technologies.

Southern Company Services

2009-01-31

102

Heatpipe power system development  

International Nuclear Information System (INIS)

This is the final report of a one-year, Laboratory Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). The objective of the project was to develop a design approach that could enable the development of near-term, low-cost, space fission-power systems. Sixteen desired attributes were identified for such systems and detailed analyses were performed to verify that they are feasible. Preliminary design work was performed on one concept, the Heatpipe Power system (HPS). As a direct result of this project, funding was obtained from the National Aeronautics and Space Administration to build and test an HPS module. The module tests went well, and they now have funding to build a bimodal module

103

Development of heating system  

International Nuclear Information System (INIS)

The detailed designs and development of components of NBI, RF, ECH, and LHCD heating and current drive system have been performed. The prototype ion source for the KSTAR NBI system and the beam line components such as calorimeter, neutralizer, bending magnet, and ion dump had been developed. The power supplies for the stable beam of 120 kV and 65 A including acceleration power supply, deceleration power supply, arc power supply, and filament power supply have been developed. Finally a KSATR NB test facility has been completed at KAERI to test and upgrade the ion source and the beam line components. The RF system is under development. Antenna has been fabricated and tested. Transmission components (vacuum feedthrough, impedance matching and water-cooled transmission line) for transmitting MW level of power have been developed. For transmitter, we optimized performance of 100kW transmitter and completed the fabrication of 300 kW transmitter. We will finalize the procurement specification of 2 MW transmitter system in the third phase. The detailed design of a 500 kW, 84 GHz ECH system has been completed. The gyrotron has been fabricated and successfully tested at Communications and Power Industries(CPI), USA. It is delivered to POSTECH, and under short pulse conditioning test with a pulse modulator operated at 20 ?s with 60 Hz repetition rate and a acceleration power supply (APS). The ECH transmission line components are being purchased from General Atomics (GA), USA. The LH frequency of the 2.0 MW LHCD system is chosen to 5.0 GHz for extending the density limit condition. The LHCD system is under design process. The basic design of the 5.0 GHz LHCD launcher (coupler) has been finished using the HFSS and ANSYS programs

104

Adaptive information system development  

OpenAIRE

Information system development (ISD) is being conducted in an increasingly turbulent and complex environment. New forms of ISD are emerging, such as open source software and agile methods but theory is needed to explain and help improve the organization of ISD. Complex Adaptive Systems (CAS) provides a novel perspective to understand and describe new forms of ISD and provide a theoretical foundation for researchers. This paper provides an overview of CAS and a review of its app...

Vidgen, Richard; Wang, Xiaofeng

2004-01-01

105

Dynamic autophosphorylation of mps1 kinase is required for faithful mitotic progression.  

Science.gov (United States)

The spindle assembly checkpoint (SAC) is a surveillance mechanism monitoring cell cycle progression, thus ensuring accurate chromosome segregation. The conserved mitotic kinase Mps1 is a key component of the SAC. The human Mps1 exhibits comprehensive phosphorylation during mitosis. However, the related biological relevance is largely unknown. Here, we demonstrate that 8 autophosphorylation sites within the N-terminus of Mps1, outside of the catalytic domain, are involved in regulating Mps1 kinetochore localization. The phospho-mimicking mutant of the 8 autophosphorylation sites impairs Mps1 localization to kinetochore and also affects the kinetochore recruitment of BubR1 and Mad2, two key SAC effectors, subsequently leading to chromosome segregation errors. Interestingly, the non-phosphorylatable mutant of the 8 autophosphorylation sites enhances Mps1 kinetochore localization and delays anaphase onset. We further show that the Mps1 phospho-mimicking and non-phosphorylatable mutants do not affect metaphase chromosome congression. Thus, our results highlight the importance of dynamic autophosphorylation of Mps1 in regulating accurate chromosome segregation and ensuring proper mitotic progression. PMID:25265012

Wang, Xinghui; Yu, Huijuan; Xu, Leilei; Zhu, Tongge; Zheng, Fan; Fu, Chuanhai; Wang, Zhiyong; Dou, Zhen

2014-01-01

106

LANL receiver system development  

Energy Technology Data Exchange (ETDEWEB)

The CALIOPE receiver system development at LANL is the story of two technologies. The first of these technologies consists of off-the-shelf mercury-cadmium-telluride (MCT) detectors and amplifiers. The vendor for this system is Kolmar Technologies. This system was fielded in the Tan Trailer I (TTI) in 1995 and will be referred to in this paper as GEN I. The second system consists of a MCT detector procured from Santa Barbara Research Center (SBRC) and an amplifier designed and built by LANL. This system was fielded in the Tan Trailer II (TTII) system at the NTS tests in 1996 and will be referred to as GEN II. The LANL CALIOPE experimental plan for 1996 was to improve the lidar system by progressing to a higher rep rate laser to perform many shots in a much shorter period of time. In keeping with this plan, the receiver team set a goal of developing a detector system that was background limited for the projected 100 nanosecond (ns) laser pulse. A set of detailed simulations of the DIAL lidar experiment was performed. From these runs, parameters such as optimal detector size, field of view of the receiver system, nominal laser return power, etc. were extracted. With this information, detector physics and amplifier electronic models were developed to obtain the required specifications for each of these components. These derived specs indicated that a substantial improvement over commercially available, off-the-shelf, amplifier and detector technologies would be needed to obtain the goals. To determine if the original GEN I detector was usable, the authors performed tests on a 100 micron square detector at cryogenic temperatures. The results of this test and others convinced them that an advanced detector was required. Eventually, a suitable detector was identified and a number of these single element detectors were procured from SBRC. These single element detectors were witness for the detector arrays built for another DOE project.

Laubscher, B.; Cooke, B.; Cafferty, M.; Olivas, N.

1997-08-01

107

Mps1 phosphorylation of condensin II controls chromosome condensation at the onset of mitosis.  

Science.gov (United States)

During mitosis, genomic DNA is condensed into chromosomes to promote its equal segregation into daughter cells. Chromosome condensation occurs during cell cycle progression from G2 phase to mitosis. Failure of chromosome compaction at prophase leads to subsequent misregulation of chromosomes. However, the molecular mechanism that controls the early phase of mitotic chromosome condensation is largely unknown. Here, we show that Mps1 regulates initial chromosome condensation during mitosis. We identify condensin II as a novel Mps1-associated protein. Mps1 phosphorylates one of the condensin II subunits, CAP-H2, at Ser492 during mitosis, and this phosphorylation event is required for the proper loading of condensin II on chromatin. Depletion of Mps1 inhibits chromosomal targeting of condensin II and accurate chromosome condensation during prophase. These findings demonstrate that Mps1 governs chromosomal organization during the early stage of mitosis to facilitate proper chromosome segregation. PMID:24934155

Kagami, Yuya; Nihira, Keishi; Wada, Shota; Ono, Masaya; Honda, Mariko; Yoshida, Kiyotsugu

2014-06-23

108

Mps1 phosphorylation of condensin II controls chromosome condensation at the onset of mitosis  

Science.gov (United States)

During mitosis, genomic DNA is condensed into chromosomes to promote its equal segregation into daughter cells. Chromosome condensation occurs during cell cycle progression from G2 phase to mitosis. Failure of chromosome compaction at prophase leads to subsequent misregulation of chromosomes. However, the molecular mechanism that controls the early phase of mitotic chromosome condensation is largely unknown. Here, we show that Mps1 regulates initial chromosome condensation during mitosis. We identify condensin II as a novel Mps1-associated protein. Mps1 phosphorylates one of the condensin II subunits, CAP-H2, at Ser492 during mitosis, and this phosphorylation event is required for the proper loading of condensin II on chromatin. Depletion of Mps1 inhibits chromosomal targeting of condensin II and accurate chromosome condensation during prophase. These findings demonstrate that Mps1 governs chromosomal organization during the early stage of mitosis to facilitate proper chromosome segregation. PMID:24934155

Kagami, Yuya; Nihira, Keishi; Wada, Shota; Ono, Masaya; Honda, Mariko

2014-01-01

109

Condensing behavior of a freon bubble with MPS-MAFL  

International Nuclear Information System (INIS)

In the study, MPS-MAFL is used to simulate the phenomena of a Freon bubble condensing in a subcooled pool. The sensitivity on pool subcooling is also studied to understand the condensation behavior. The simulating shows that the bubble pressure decreases as the condensation begins with the shrinking of the interface. At the later phase of the condensation, the bubble pressure becomes larger than that of the circumstance. A peak pressure will emerge at the moment that the bubble collapses and there will be a maximum pressure value at a certain subcooling. As the subcooling increases or decreases, the peak pressure will drop and may fade away. The maximum pressure is 3.12 MPa at a subcooling about 20?. (authors)

110

The Yeast CDC37 Gene Interacts with MPS1 and Is Required for Proper Execution of Spindle Pole Body Duplication  

OpenAIRE

The MPS1 gene from Saccharomyces cerevisiae encodes an essential protein kinase required for spindle pole body (SPB) duplication and for the mitotic spindle assembly checkpoint. Cells with the mps1-1 mutation fail early in SPB duplication and proceed through monopolar mitosis with lethal consequences. We identified CDC37 as a multicopy suppressor of mps1-1 temperature-sensitive growth. Suppression is allele specific, and synthetic lethal interactions occur between mps1 and cdc37 allele...

Schutz, Amy R.; Giddings, Thomas H.; Steiner, Estelle; Winey, Mark

1997-01-01

111

A DSP-Based Beam Current Monitoring System for Machine Protection Using Adaptive Filtering  

International Nuclear Information System (INIS)

The CEBAF accelerator at Jefferson Lab is currently using an analog beam current monitoring (BCM) system for its machine protection system (MPS), which has a loss accuracy of 2 micro-amps. Recent burn-through simulations predict catastrophic beam line component failures below 1 micro-amp of loss, resulting in a blind spot for the MPS. Revised MPS requirements target an ultimate beam loss accuracy of 250 nA. A new beam current monitoring system has been developed which utilizes modern digital receiver technology and digital signal processing concepts. The receiver employs a direct-digital down converter integrated circuit, mated with a Jefferson Lab digital signal processor VME card. Adaptive filtering is used to take advantage of current-dependent burn-through rates. Benefits of such a system include elimination of DC offsets, generic algorithm development, extensive filter options, and interfaces to UNIX-based control systems

112

Structural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint).  

Science.gov (United States)

The SAC (spindle assembly checkpoint) is a surveillance system that ensures the timely and accurate transmission of the genetic material to offspring. The process implies kinetochore targeting of the mitotic kinases Bub1 (budding uninhibited by benzamidine 1), BubR1 (Bub1 related) and Mps1 (monopolar spindle 1), which is mediated by the N-terminus of each kinase. In the present study we report the 1.8 Å (1 Å=0.1 nm) crystal structure of the TPR (tetratricopeptide repeat) domain in the N-terminal region of human Mps1. The structure reveals an overall high similarity to the TPR motif of the mitotic checkpoint kinases Bub1 and BubR1, and a number of unique features that include the absence of the binding site for the kinetochore structural component KNL1 (kinetochore-null 1; blinkin), and determinants of dimerization. Moreover, we show that a stretch of amino acids at the very N-terminus of Mps1 is required for dimer formation, and that interfering with dimerization results in mislocalization and misregulation of kinase activity. The results of the present study provide an important insight into the molecular details of the mitotic functions of Mps1 including features that dictate substrate selectivity and kinetochore docking. PMID:23067341

Thebault, Philippe; Chirgadze, Dimitri Y; Dou, Zhen; Blundell, Tom L; Elowe, Sabine; Bolanos-Garcia, Victor M

2012-12-15

113

The machine protection system for the Energy Recovery Linac  

International Nuclear Information System (INIS)

The Machine Protection System (MPS) is a device safety system that is designed to prevent damage to hardware by generating interlocks, based upon the state of input signals generated by selected sub-systems. It protects all the key machinery in the Project called the Energy Recovery LINAC (ERL) against the high beam current. The MPS is capable of responding to a fault with an interlock signal within several microseconds. The ERL MPS is based on a National Instruments CompactRIO platform, and is programmed by utilizing National Instruments' development environment for a visual programming language. The system also transfers data (interlock status, time of fault, etc.) to the main server. Transferred data is integrated into the pre-existing software architecture which is accessible by the operators. This paper will provide an overview of the hardware used, its configuration and operation, as well as the software written both on the device and the server side. (authors)

114

Parental social support, coping strategies, resilience factors, stress, anxiety and depression levels in parents of children with MPS III (Sanfilippo syndrome) or children with intellectual disabilities (ID).  

Science.gov (United States)

Mucopolysaccharidosis type III (MPS III, Sanfilippo syndrome) is a lysosomal storage disorder, caused by a deficiency in one of four enzymes involved in the catabolism of the glycosaminoglycan heparan sulphate. It is a degenerative disorder, with a progressive decline in children's intellectual and physical functioning. There is currently no cure for the disorder. To date there is a paucity of research on how this disorder impacts parents psychological functioning. Specifically, research in the area has failed to employ adequate control groups to assess if the impact of this disorder on parents psychological functioning differs from parenting a child with intellectual disability (ID). The current study examined child behaviour and parental psychological functioning in 23 parents of children with MPS III and 23 parents of children with ID. Parents completed postal questionnaires about their child's behaviour and abilities and their own psychological functioning. Parents of children with MPS III reported fewer behavioural difficulties as their child aged, more severe level of intellectual disability, and similar levels of perceived social support, coping techniques, stress, anxiety and depression levels as parents of children with ID. Both groups of parents scored above the clinical cut off for anxiety and depression. Parents of children with MPS III rated themselves as significantly less future-orientated and goal directed than parents of children with ID. Services should develop support packages for parents of children with MPS III that incorporate an understanding of the unique stressors and current-difficulty approach of this population. Future research should examine gender differences between parental psychological functioning, using mixed qualitative and quantitative approaches, and utilise matched developmental level and typically developing control groups. PMID:23151683

Grant, Sheena; Cross, Elaine; Wraith, James Edmond; Jones, Simon; Mahon, Louise; Lomax, Michelle; Bigger, Brian; Hare, Dougal

2013-03-01

115

Spindle checkpoint-independent inhibition of mitotic chromosome segregation by Drosophila Mps1.  

Science.gov (United States)

Monopolar spindle 1 (Mps1) is essential for the spindle assembly checkpoint (SAC), which prevents anaphase onset in the presence of misaligned chromosomes. Moreover, Mps1 kinase contributes in a SAC-independent manner to the correction of erroneous initial attachments of chromosomes to the spindle. Our characterization of the Drosophila homologue reveals yet another SAC-independent role. As in yeast, modest overexpression of Drosophila Mps1 is sufficient to delay progression through mitosis during metaphase, even though chromosome congression and metaphase alignment do not appear to be affected. This delay in metaphase depends on the SAC component Mad2. Although Mps1 overexpression in mad2 mutants no longer causes a metaphase delay, it perturbs anaphase. Sister kinetochores barely move apart toward spindle poles. However, kinetochore movements can be restored experimentally by separase-independent resolution of sister chromatid cohesion. We propose therefore that Mps1 inhibits sister chromatid separation in a SAC-independent manner. Moreover, we report unexpected results concerning the requirement of Mps1 dimerization and kinase activity for its kinetochore localization in Drosophila. These findings further expand Mps1's significance for faithful mitotic chromosome segregation and emphasize the importance of its careful regulation. PMID:22553353

Althoff, Friederike; Karess, Roger E; Lehner, Christian F

2012-06-01

116

Geological disposal system development  

Energy Technology Data Exchange (ETDEWEB)

Spent fuel inventories to be disposed of finally and design base spent fuel were determined. Technical and safety criteria for a geological repository system in Korea were established. Based on the properties of spent PWR and CANDU fuels, seven repository alternatives were developed and the most promising repository option was selected by the pair-wise comparison method from the technology point of view. With this option preliminary conceptual design studies were carried out. Several module, e.g., gap module, congruent release module were developed for the overall assessment code MASCOT-K. The prominent overseas databases such as OECD/NEA FEP list were are fully reviewed and then screened to identify the feasible ones to reflect the Korean geo-hydrological conditions. In addition to this the well known scenario development methods such as PID, RES were reviewed. To confirm the radiological safety of the proposed KAERI repository concept the preliminary PA was pursued. Thermo-hydro-mechanical analysis for the near field of repository were performed to verify thermal and mechanical stability for KAERI repository system. The requirements of buffer material were analyzed, and based on the results, the quantitative functional criteria for buffer material were established. The hydraulic and swelling property, mechanical properties, and thermal conductivity, the organic carbon content, and the evolution of pore water chemistry were investigated. Based on the results, the candidate buffer material was selected.

Kang, Chul Hyung; Kuh, J. E.; Kim, S. K. and others

2000-04-01

117

Geological disposal system development  

International Nuclear Information System (INIS)

Spent fuel inventories to be disposed of finally and design base spent fuel were determined. Technical and safety criteria for a geological repository system in Korea were established. Based on the properties of spent PWR and CANDU fuels, seven repository alternatives were developed and the most promising repository option was selected by the pair-wise comparison method from the technology point of view. With this option preliminary conceptual design studies were carried out. Several module, e.g., gap module, congruent release module were developed for the overall assessment code MASCOT-K. The prominent overseas databases such as OECD/NEA FEP list were are fully reviewed and then screened to identify the feasible ones to reflect the Korean geo-hydrological conditions. In addition to this the well known scenario development methods such as PID, RES were reviewed. To confirm the radiological safety of the proposed KAERI repository concept the preliminary PA was pursued. Thermo-hydro-mechanical analysis for the near field of repository were performed to verify thermal and mechanical stability for KAERI repository system. The requirements of buffer material were analyzed, and based on the results, the quantitative functional criteria for buffer material were established. The hydraulic and swelling property, mechanical properties, and thermal conductivity, the organic carbon content, and the evolution of pore water chemistry were investigated. Based on the results, the candidate buffer material was selected

118

Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase.  

OpenAIRE

The MPS1 gene has been previously identified by a mutant allele that shows defects in spindle pole body (SPB) duplication and cell cycle control. The SPB is the centrosome-equivalent organelle in the yeast Saccharomyces cerevisiae, and it nucleates all the microtubules in the cell. We report the isolation of the MPS1 gene, which encodes an essential protein kinase homolog. The MPS1 open reading frame has been fused to those that encode the LexA protein or the GST protein and both of these con...

Lauze?, E.; Stoelcker, B.; Luca, F. C.; Weiss, E.; Schutz, A. R.; Winey, M.

1995-01-01

119

Advanced Dewatering Systems Development  

Energy Technology Data Exchange (ETDEWEB)

A new fine coal dewatering technology has been developed and tested in the present work. The work was funded by the Solid Fuels and Feedstocks Grand Challenge PRDA. The objective of this program was to 'develop innovative technical approaches to ensure a continued supply of environmentally sound solid fuels for existing and future combustion systems with minimal incremental fuel cost.' Specifically, this solicitation is aimed at developing technologies that can (i) improve the efficiency or economics of the recovery of carbon when beneficiating fine coal from both current production and existing coal slurry impoundments and (ii) assist in the greater utilization of coal fines by improving the handling characteristics of fine coal via dewatering and/or reconstitution. The results of the test work conducted during Phase I of the current project demonstrated that the new dewatering technologies can substantially reduce the moisture from fine coal, while the test work conducted during Phase II successfully demonstrated the commercial viability of this technology. It is believed that availability of such efficient and affordable dewatering technology is essential to meeting the DOE's objectives.

R.H. Yoon; G.H. Luttrell

2008-07-31

120

Power Systems Development Facility  

Energy Technology Data Exchange (ETDEWEB)

This report discusses Test Campaign TC12 of the Kellogg Brown & Root, Inc. (KBR) Transport Gasifier train with a Siemens Westinghouse Power Corporation (SW) particle filter system at the Power Systems Development Facility (PSDF) located in Wilsonville, Alabama. The Transport Gasifier is an advanced circulating fluidized-bed reactor designed to operate as either a combustor or a gasifier using a particulate control device (PCD). While operating as a gasifier, either air or oxygen can be used as the oxidant. Test run TC12 began on May 16, 2003, with the startup of the main air compressor and the lighting of the gasifier start-up burner. The Transport Gasifier operated until May 24, 2003, when a scheduled outage occurred to allow maintenance crews to install the fuel cell test unit and modify the gas clean-up system. On June 18, 2003, the test run resumed when operations relit the start-up burner, and testing continued until the scheduled end of the run on July 14, 2003. TC12 had a total of 733 hours using Powder River Basin (PRB) subbituminous coal. Over the course of the entire test run, gasifier temperatures varied between 1,675 and 1,850 F at pressures from 130 to 210 psig.

None

2003-07-01

121

Power Systems Development Facility  

International Nuclear Information System (INIS)

The objective of the PSDF would be to provide a modular facility which would support the development of advanced, pilot-scale, coal-based power systems and hot gas clean-up components. These pilot-scale components would be designed to be large enough so that the results can be related and projected to commercial systems. The facility would use a modular approach to enhance the flexibility and capability for testing; consequently, overall capital and operating costs when compared with stand-alone facilities would be reduced by sharing resources common to different modules. The facility would identify and resolve technical barrier, as well as-provide a structure for long-term testing and performance assessment. It is also intended that the facility would evaluate the operational and performance characteristics of the advanced power systems with both bituminous and subbituminous coals. Five technology-based experimental modules are proposed for the PSDF: (1) an advanced gasifier module, (2) a fuel cell test module, (3) a PFBC module, (4) a combustion gas turbine module, and (5) a module comprised of five hot gas cleanup particulate control devices. The final module, the PCD, would capture coal-derived ash and particles from both the PFBC and advanced gasifier gas streams to provide for overall particulate emission control, as well as to protect the combustion turbine and the fuel cell

122

Power Systems Development Facility  

Energy Technology Data Exchange (ETDEWEB)

This report discusses Test Campaign TC15 of the Kellogg Brown & Root, Inc. (KBR) Transport Gasifier train with a Siemens Power Generation, Inc. (SPG) particle filter system at the Power Systems Development Facility (PSDF) located in Wilsonville, Alabama. The Transport Gasifier is an advanced circulating fluidized-bed reactor designed to operate as either a combustor or gasifier using a particulate control device (PCD). While operating as a gasifier, either air or oxygen can be used as the oxidant. Test run TC15 began on April 19, 2004, with the startup of the main air compressor and the lighting of the gasifier startup burner. The Transport Gasifier was shutdown on April 29, 2004, accumulating 200 hours of operation using Powder River Basin (PRB) subbituminous coal. About 91 hours of the test run occurred during oxygen-blown operations. Another 6 hours of the test run was in enriched-air mode. The remainder of the test run, approximately 103 hours, took place during air-blown operations. The highest operating temperature in the gasifier mixing zone mostly varied from 1,800 to 1,850 F. The gasifier exit pressure ran between 200 and 230 psig during air-blown operations and between 110 and 150 psig in oxygen-enhanced air operations.

Southern Company Services

2004-04-30

123

A chemical tool box defines mitotic and interphase roles for Mps1 kinase  

OpenAIRE

In this issue, three groups (Hewitt et al. 2010. J. Cell Biol. doi:10.1083/jcb.201002133; Maciejowski et al. 2010. J. Cell Biol. doi:10.1083/jcb.201001050; Santaguida et al. 2010. J. Cell Biol. doi:10.1083/jcb.201001036) use chemical inhibitors to analyze the function of the mitotic checkpoint kinase Mps1. These studies demonstrate that Mps1 kinase activity ensures accurate chromosome segregation through its recruitment to kinetochores of mitotic checkpoint proteins, formation of interphase a...

Lan, Weijie; Cleveland, Don W.

2010-01-01

124

Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1  

OpenAIRE

Aneuploidy, resulting from chromosome missegregation during meiosis, is a major cause of human infertility and birth defects. However, its molecular basis remains incompletely understood. Here we have identified a spectrum of chromosome anomalies in embryos of zebrafish homozygous for a hypomorphic mutation in Mps1, a kinase required for the mitotic checkpoint. These aneuploidies are caused by meiotic error and result in severe developmental defects. Our results reveal Mps1 as a critical regu...

Poss, Kenneth D.; Nechiporuk, Alex; Stringer, Keith F.; Lee, Charles; Keating, Mark T.

2004-01-01

125

Centriole assembly and the role of Mps1: defensible or dispensable?  

OpenAIRE

Abstract The Mps1 protein kinase is an intriguing and controversial player in centriole assembly. Originally shown to control duplication of the budding yeast spindle pole body, Mps1 is present in eukaryotes from yeast to humans, the nematode C. elegans being a notable exception, and has also been shown to regulate the spindle checkpoint and an increasing number of cellular functions relating to genomic stability. While its function in the spindle checkpoint appears to be b...

Fisk Harold A; Pike Amanda N

2011-01-01

126

Lead optimization of purine based orally bioavailable Mps1 (TTK) inhibitors.  

Science.gov (United States)

Efforts to optimize biological activity, novelty, selectivity and oral bioavailability of Mps1 inhibitors, from a purine based lead MPI-0479605, are described in this Letter. Mps1 biochemical activity and cytotoxicity in HCT-116 cell line were improved. On-target activity confirmation via mechanism based G2/M escape assay was demonstrated. Physico-chemical and ADME properties were optimized to improve oral bioavailability in mouse. PMID:22632936

Vijay Kumar, D; Hoarau, Christophe; Bursavich, Matthew; Slattum, Paul; Gerrish, David; Yager, Kraig; Saunders, Michael; Shenderovich, Mark; Roth, Bruce L; McKinnon, Rena; Chan, Ashley; Cimbora, Daniel M; Bradford, Chad; Reeves, Leslie; Patton, Scott; Papac, Damon I; Williams, Brandi L; Carlson, Robert O

2012-07-01

127

MPs for Sale? Estimating Returns to Office in Post-War British Politics  

OpenAIRE

While the role of money in policymaking is a central question in political economy research, surprisingly little attention has been given to the rents politicians actually derive from politics. We use both matching and a regression discontinuity design to analyze an original dataset on the estates of recently deceased British politicians. We find that serving in Parliament roughly doubled the wealth at death of Conservative MPs but had no discernible effect on the wealth of Labour MPs. We arg...

Eggers, Andy; Hainmueller, Jens

2008-01-01

128

POWER SYSTEMS DEVELOPMENT FACILITY  

Energy Technology Data Exchange (ETDEWEB)

This report discusses test campaign GCT4 of the Kellogg Brown & Root, Inc. (KBR) transport reactor train with a Siemens Westinghouse Power Corporation (Siemens Westinghouse) particle filter system at the Power Systems Development Facility (PSDF) located in Wilsonville, Alabama. The transport reactor is an advanced circulating fluidized-bed reactor designed to operate as either a combustor or a gasifier using one of two possible particulate control devices (PCDs). The transport reactor was operated as a pressurized gasifier during GCT4. GCT4 was planned as a 250-hour test run to continue characterization of the transport reactor using a blend of several Powder River Basin (PRB) coals and Bucyrus limestone from Ohio. The primary test objectives were: Operational Stability--Characterize reactor loop and PCD operations with short-term tests by varying coal-feed rate, air/coal ratio, riser velocity, solids-circulation rate, system pressure, and air distribution. Secondary objectives included the following: Reactor Operations--Study the devolatilization and tar cracking effects from transient conditions during transition from start-up burner to coal. Evaluate the effect of process operations on heat release, heat transfer, and accelerated fuel particle heat-up rates. Study the effect of changes in reactor conditions on transient temperature profiles, pressure balance, and product gas composition. Effects of Reactor Conditions on Synthesis Gas Composition--Evaluate the effect of air distribution, steam/coal ratio, solids-circulation rate, and reactor temperature on CO/CO{sub 2} ratio, synthesis gas Lower Heating Value (LHV), carbon conversion, and cold and hot gas efficiencies. Research Triangle Institute (RTI) Direct Sulfur Recovery Process (DSRP) Testing--Provide syngas in support of the DSRP commissioning. Loop Seal Operations--Optimize loop seal operations and investigate increases to previously achieved maximum solids-circulation rate.

Unknown

2002-11-01

129

Bone marrow transplantation in patients with storage diseases: a developing country experience  

Directory of Open Access Journals (Sweden)

Full Text Available Bone marrow transplantation (BMT is a therapeutic option for patients with genetic storage diseases. Between 1979 and 2002, eight patients, four females and four males (1 to 13 years old were submitted to this procedure in our center. Six patients had mucopolysaccharidosis (MPS I in 3; MPS III in one and MPS VI in 2, one had adrenoleukodystrophy (ALD and one had Gaucher disease. Five patients had related and three unrelated BMT donor. Three patients developed graft versus host disease (two MPS I and one MPS VI and died between 37 and 151 days after transplantation. Five patients survived 4 to 16 years after transplantation. Three patients improved (one MPS I; one MPS VI and the Gaucher disease patient, one patient had no disease progression (ALD and in one patient this procedure did not change the natural course of the disease (MPS III.

Lange Marcos C.

2006-01-01

130

Experiments and MPS analysis of stratification behavior of two immiscible fluids  

International Nuclear Information System (INIS)

Highlights: • Improving numerical stability of MPS method. • Implicitly calculating viscous term in momentum equation for highly viscous fluids. • Validation of the enhanced MPS method by analyzing dam break problem. • Various stratification behavior analysis by experiments and simulations. • Sensitivity analysis of the effects of the fluid viscosity and density difference. - Abstract: Stratification behavior is of great significance in the late in-vessel stage of core melt severe accident of a nuclear reactor. Conventional numerical methods have difficulties in analyzing stratification process accompanying with free surface without depending on empirical correlations. The Moving Particle Semi-implicit (MPS) method, which calculates free surface and multiphase flow without empirical equations, is applicable for analyzing the stratification behavior of fluids. In the present study, the original MPS method was improved to simulate the stratification behavior of two immiscible fluids. The improved MPS method was validated through simulating classical dam break problem. Then, the stratification processes of two fluid columns and injected fluid were investigated through experiments and simulations, using silicone oil and salt water as the simulant materials. The effects of fluid viscosity and density difference on stratification behavior were also sensitively investigated by simulations. Typical fluid configurations at various parametric and geometrical conditions were observed and well predicted by improved MPS method

131

Musculoskeletal health in Hunter disease (MPS II): ERT improves functional outcomes.  

Science.gov (United States)

Musculoskeletal disease is a significant burden for children with Mucopolysaccharide (MPS) disorders. The Pediatric Outcomes Data Collection Instrument (PODCI) is a validated, functional measure of musculoskeletal health in children with disabilities. The goal of this study is to describe the musculoskeletal manifestations of children with MPS II (Hunter syndrome), and their functional response to intravenous enzyme replacement therapy (ERT). Patients with MPS II were prospectively entered into an IRB approved registry. Chart review of physical findings including, shoulder, elbow, hip, knee and ankle range of motion, and need for carpal tunnel release was performed. Radiographs of the spine and pelvis were evaluated in all patients. Serial PODCI exams were administered to all patients. Seven patients, 5 receiving ERT, were included. Four patients had spinal deformities, seven had modest hip disease, and two required carpal tunnel release. PODCI scores were abnormally low in all domains, but significant improvements in PODCI scores were documented with enzyme replacement therapy. Spine and hip deformity are ubiquitous in MPS II, none of which have required surgical intervention, but require long term monitoring. Patients with MPS II should be monitored for carpal tunnel syndrome. Functional improvements are seen, as documented by the PODCI, in children with MPS II on ERT. PMID:21791837

White, Klane K; Hale, Susan; Goldberg, Michael J

2010-01-01

132

Development of two-dimensional position sensitive detector systems using multi-pixel photon counters for neutron experiments  

International Nuclear Information System (INIS)

Neutron scattering experiments are indispensable to the structural analysis of many types of condensed matter and in the development of advanced materials. A high resolution detector system and a high counting rate detector system, both utilizing a neutron scintillator and multi-pixel photon counters (MPPCs), have been developed at the High-Energy Accelerator Research Organization (KEK). These systems will be used in the BL16 and BL06 neutron scattering instruments at the Material and Life Science Facility (MLF) in the Japan Proton Accelerator Research Complex (J-PARC). The high resolution detector is an MPPC position-sensitive detector (MPS) with a 105×128 mm2 detection area and has positional resolution of 1 mm. The high counting rate detector is an MPPC Pixel detector (MPIX) with a 320×40 mm2 detection area. The maximum counting rate is 4 million counts per second (Mcps)

133

The yeast protein kinase Mps1p is required for assembly of the integral spindle pole body component Spc42p  

OpenAIRE

Saccharomyces cerevisiae MPS1 encodes an essential protein kinase that has roles in spindle pole body (SPB) duplication and the spindle checkpoint. Previously characterized MPS1 mutants fail in both functions, leading to aberrant DNA segregation with lethal consequences. Here, we report the identification of a unique conditional allele, mps1–8, that is defective in SPB duplication but not the spindle checkpoint. The mutations in mps1-8 are in the noncatalytic region of MPS1, and analysis of...

Castillo, Andrea R.; Meehl, Janet B.; Morgan, Garry; Schutz-geschwender, Amy; Winey, Mark

2002-01-01

134

CheMPS2: a free open-source spin-adapted implementation of the density matrix renormalization group for ab initio quantum chemistry  

CERN Document Server

The density matrix renormalization group (DMRG) has become an indispensable numerical tool to find exact eigenstates of finite-size quantum systems with strong correlation. In the fields of condensed matter, nuclear structure and molecular electronic structure, it has significantly extended the system sizes that can be handled compared to full configuration interaction, without losing numerical accuracy. For quantum chemistry (QC), the most efficient implementations of DMRG require the incorporation of particle number, spin and point group symmetries in the underlying matrix product state (MPS) ansatz, as well as the use of so-called complementary operators. The symmetries introduce a sparse block structure in the MPS ansatz and in the intermediary contracted tensors. If a symmetry is non-abelian, the Wigner-Eckart theorem allows to factorize a tensor into a Clebsch-Gordan coefficient and a reduced tensor. In addition, the fermion signs have to be carefully tracked. Because of these challenges, implementing D...

Wouters, Sebastian; Ayers, Paul W; Van Neck, Dimitri

2013-01-01

135

POWER SYSTEMS DEVELOPMENT FACILITY  

Energy Technology Data Exchange (ETDEWEB)

This report discusses test campaign GCT3 of the Halliburton KBR transport reactor train with a Siemens Westinghouse Power Corporation (Siemens Westinghouse) particle filter system at the Power Systems Development Facility (PSDF) located in Wilsonville, Alabama. The transport reactor is an advanced circulating fluidized-bed reactor designed to operate as either a combustor or a gasifier using one of two possible particulate control devices (PCDs). The transport reactor was operated as a pressurized gasifier during GCT3. GCT3 was planned as a 250-hour test run to commission the loop seal and continue the characterization of the limits of operational parameter variations using a blend of several Powder River Basin coals and Bucyrus limestone from Ohio. The primary test objectives were: (1) Loop Seal Commissioning--Evaluate the operational stability of the loop seal with sand and limestone as a bed material at different solids circulation rates and establish a maximum solids circulation rate through the loop seal with the inert bed. (2) Loop Seal Operations--Evaluate the loop seal operational stability during coal feed operations and establish maximum solids circulation rate. Secondary objectives included the continuation of reactor characterization, including: (1) Operational Stability--Characterize the reactor loop and PCD operations with short-term tests by varying coal feed, air/coal ratio, riser velocity, solids circulation rate, system pressure, and air distribution. (2) Reactor Operations--Study the devolatilization and tar cracking effects from transient conditions during transition from start-up burner to coal. Evaluate the effect of process operations on heat release, heat transfer, and accelerated fuel particle heat-up rates. Study the effect of changes in reactor conditions on transient temperature profiles, pressure balance, and product gas composition. (3) Effects of Reactor Conditions on Syngas Composition--Evaluate the effect of air distribution, steam/coal ratio, solids circulation rate, and reactor temperature on CO/CO{sub 2} ratio, H{sub 2}/converted carbon ratio, gasification rates, carbon conversion, and cold and hot gas efficiencies. Test run GCT3 was started on December 1, 2000, with the startup of the thermal oxidizer fan, and was completed on February 1, 2001. This test was conducted in two parts; the loop seal was commissioned during the first part of this test run from December 1 through 15, which consisted of hot inert solids circulation testing. These initial tests provided preliminary data necessary to understand different parameters associated with the operation and performance of the loop seal. The loop seal was tested with coal feed during the second part of the test run and additional data was gathered to analyze reactor operations and to identify necessary modifications to improve equipment and process performance. In the second part of GCT3, the gasification portion of the test, from January 20 to February 1, 2001, the mixing zone and riser temperatures were varied between 1,675 and 1,825 F at pressures ranging from 200 to 240 psig. There were 306 hours of solid circulation and 184 hours of coal feed attained in GCT3.

Unknown

2002-05-01

136

Bub1, Sgo1, and Mps1 mediate a distinct pathway for chromosome biorientation in budding yeast  

OpenAIRE

Members of chromosome passenger complex BIR1 and SLI15 suppress the chromosome segregation defect of bub1? and sgo1?. Neither Bub1 nor Sgo1 is required for CPC activity. This study found genetic interaction between Mps1 and Sgo1. Mps1 governs localization of Sgo1. Bub1, Sgo1, and Mps1 function in parallel to the CPC in correction of syntelic attachments.

Storchova?, Zuzana; Becker, Justin S.; Talarek, Nicolas; Ko?gelsberger, Sandra; Pellman, David

2011-01-01

137

STUDI DAYA HAMBAT IN VITRO ANTI MPS ECTO CIK (MAYOR PHYSIOLOGICAL PROTEIN SUBSTRAT) TERHADAP VIABILITAS SPERMATOZOA KAMBING DAN DOMBA  

OpenAIRE

Untuk menuju suatu penemuan tentang vaksin kontrasepsi bagi pria, diperlukan penelitian dasar mengenai hal tersebut. Sebagai langkah awal dilakukan uji hambatan Anti MPS ecto CIK terhadap viabilitas spermatozoa kambing dan domba, sedangkan dari penelitian pendahuluan diketahui bahwa anti MPS dari ecto-CIK ini mampu bereaksi silang dengan spermatozoa domba, dan sapi. Berdasarkan hal tersebut peneliti tertarik untuk mengetahui seberapa besar peranan anti MPS ecto CIK dalam menghambat viabilita...

Bayyinatul Muchtaromah

2009-01-01

138

Framework for control system development  

International Nuclear Information System (INIS)

Control systems being developed for the present generation of accelerators will need to adapt to changing machine and operating state conditions. Such systems must also be capable of evolving over the life of the accelerator operation. In this paper we present a framework for the development of adaptive control systems

139

Interactive web system development  

OpenAIRE

With rapid spread of information technologies, more and more things and services are transferred to the virtual space. Online stores or online reservation systems has long ceased to surprise customers. The main purpose of this master thesis is to analyze and find the way to universalize online reservation process using information gathered from scientific literature analysis and from author’s research. The main objective is to create a model of a simple system for the different situations t...

Dvilevic?ius, Andrius

2014-01-01

140

UV-C irradiation delays mitotic progression by recruiting Mps1 to kinetochores.  

Science.gov (United States)

The effect of UV irradiation on replicating cells during interphase has been studied extensively. However, how the mitotic cell responds to UV irradiation is less well defined. Herein, we found that UV-C irradiation (254 nm) increases recruitment of the spindle checkpoint proteins Mps1 and Mad2 to the kinetochore during metaphase, suggesting that the spindle assembly checkpoint (SAC) is reactivated. In accordance with this, cells exposed to UV-C showed delayed mitotic progression, characterized by a prolonged chromosomal alignment during metaphase. UV-C irradiation also induced the DNA damage response and caused a significant accumulation of ?-H2AX on mitotic chromosomes. Unexpectedly, the mitotic delay upon UV-C irradiation is not due to the DNA damage response but to the relocation of Mps1 to the kinetochore. Further, we found that UV-C irradiation activates Aurora B kinase. Importantly, the kinase activity of Aurora B is indispensable for full recruitment of Mps1 to the kinetochore during both prometaphase and metaphase. Taking these findings together, we propose that UV irradiation delays mitotic progression by evoking the Aurora B-Mps1 signaling cascade, which exerts its role through promoting the association of Mps1 with the kinetochore in metaphase. PMID:23531678

Zhang, Xiaojuan; Ling, Youguo; Wang, Wenjun; Zhang, Yanhong; Ma, Qingjun; Tan, Pingping; Song, Ting; Wei, Congwen; Li, Ping; Liu, Xuedong; Ma, Runlin Z; Zhong, Hui; Cao, Cheng; Xu, Quanbin

2013-04-15

141

Chk1 and Mps1 jointly regulate correction of merotelic kinetochore attachments.  

Science.gov (United States)

If uncorrected, merotelic kinetochore attachments can induce mis-segregated chromosomes in anaphase. We show that checkpoint kinase 1 (Chk1) protects vertebrate cells against merotelic attachments and lagging chromosomes and is required for correction of merotelic attachments during a prolonged metaphase. Decreased Chk1 activity leads to hyper-stable kinetochore microtubules, unstable binding of MCAK, Kif2b and Mps1 to centromeres or kinetochores and reduced phosphorylation of Hec1 by Aurora-B. Phosphorylation of Aurora-B at serine 331 (Ser331) by Chk1 is high in prometaphase and decreases significantly in metaphase cells. We propose that Ser331 phosphorylation is required for optimal localization of MCAK, Kif2b and Mps1 to centromeres or kinetochores and for Hec1 phosphorylation. Furthermore, inhibition of Mps1 activity diminishes initial recruitment of MCAK and Kif2b to centromeres or kinetochores, impairs Hec1 phosphorylation and exacerbates merotelic attachments in Chk1-deficient cells. We propose that Chk1 and Mps1 jointly regulate Aurora-B, MCAK, Kif2b and Hec1 to correct merotelic attachments. These results suggest a role for Chk1 and Mps1 in error correction. PMID:23321637

Petsalaki, Eleni; Zachos, George

2013-03-01

142

Public Integrity and New Rules of Conduct for Romanian MPs: A Romanian Case Study  

Directory of Open Access Journals (Sweden)

Full Text Available The article refers to the problem of incompatibilities and conflicts of interests of public officials in the Romanian society and its severe consequences upon the fulfillment of the conditions of the European Commission Verification and Cooperation Mechanism’s benchmarks by Romania. The present study proposes a critical analysis of recent legislative changes of the rules of conduct for MPs in Romania, relatively to the regime of incompatibilities and conflicts of interests, emphasizing the manner in which the Parliament constantly tries to limit the prerogatives of the National Integrity Agency (NIA. Special attention is paid to the analysis of incompatibilities applicable to the MPs who are simultaneously Government members. The study follows several steps: an introduction, a critical analysis of the new legislation, focusing on the new rules of conduct for MPs, an analysis of the most important case studies and conclusions. The introduction describes the problem of incompatibilities and conflicts of interest of MPs and members of Government reflected in the recent CVM Report and the position of the National Integrity Agency. The analysis of the legislation presents a critical evaluation of the new rules of conduct for MPs, adopted in 2013 by the Romanian Parliament; then, analyzing the most important and recent case studies, general patterns in the field of procedures of incompatibilities and conflicts of interests emerge. Conclusions propose legislative solutions in terms of raising the standards of public integrity.

Cynthia Carmen CURT

2013-11-01

143

Reference systems: recent developements  

Science.gov (United States)

The International Celestial Reference System (ICRS) based on VLBI observations of extragalactic radiosources, which was adopted by the International Astronomical Union (IAU) from 1st January 1998, is a fundamental change from the previous IAU celestial reference system, the FK5. This replacement has been the cause of significant changes for reference systems and Earth rotation. The property of no global rotation of the ICRS with respect to the most remote objects of the Universe has led to the revision of the classical concepts of fundamental astronomy and the adoption of the IAU 2000 Resolutions. These resolutions have provided new definitions for the celestial pole, Universal Time and parameters to be used in the transformation between celestial and terrestrial frames and a new precession-nutation model which allow for an highly accurate formulation. The implementation of these resolutions has provided microarcsecond expressions for both classical and new quantities compliant with the IAU 2000 precession-nutation model. In parallel, VLBI observations of Earth orientation referred to the ICRS are currently providing determination of the celestial position of the pole and of the Earth's angle of rotation at a submilliarcsecond level. This paper reports on these recent changes for defining and realizing the fundamental quasi-inertial celestial reference system and on their consequences for reference systems and Earth rotation studies.

Capitaine, Nicole

144

The Guided System Development Framework  

DEFF Research Database (Denmark)

The Service-Oriented Computing paradigm has had significant influence on the Internet. With the emergence of this paradigm, it is important to provide tools that help developers designing and verifying such systems. In this article, we present the Guided System Development (GSD) Framework that aids and guides the developer on the specification of the system being developed, on choosing the appropriate standard protocols suites that achieve the required security properties, on providing an implementation of the specified system, and also on allowing the verification of its security properties.

Carvalho Quaresma, Jose Nuno; Probst, Christian W.

2011-01-01

145

Liferay Portal Systems Development  

CERN Document Server

This book focuses on teaching by example. Every chapter provides an overview, and then dives right into hands-on examples so you can see and play with the solution in your own environment. This book is for Java developers who don't need any prior experience with Liferay portal. Although Liferay portal makes heavy use of open source frameworks, no prior experience of using these is assumed.

Yuan, Jonas X

2012-01-01

146

Human MPS1 Kinase Is Required for Mitotic Arrest Induced by the Loss of CENP-E from KinetochoresD?  

OpenAIRE

We have determined that the previously identified dual-specificity protein kinase TTK is the human orthologue of the yeast MPS1 kinase. Yeast MPS1 (monopolar spindle) is required for spindle pole duplication and the spindle checkpoint. Consistent with the recently identified vertebrate MPS1 homologues, we found that hMPS1 is localized to centrosomes and kinetochores. In addition, hMPS1 is part of a growing list of kinetochore proteins that are localized to nuclear pores. hMPS1 is required by ...

Liu, Song-tao; Chan, Gordon K. T.; Hittle, James C.; Fujii, Gregory; Lees, Emma; Yen, Tim J.

2003-01-01

147

Mip1 associates with both the Mps1 kinase and actin, and is required for cell cortex stability and anaphase spindle positioning  

OpenAIRE

The Mps1 family of protein kinases contributes to cell cycle control by regulating multiple microtubule cytoskeleton activities. We have uncovered a new Mps1 substrate that provides a novel link between Mps1 and the actin cytoskeleton. We have identified a conserved human Mps1 (hMps1) interacting protein and have termed Mps1 interacting protein-1 (Mip1). Mip1 defines an uncharacterized family of conserved proteins that contain coiled-coil and calponin homology domains. We demonstrate that Mip...

Mattison, Christopher P.; Stumpff, Jason; Wordeman, Linda; Winey, Mark

2011-01-01

148

Mad1 kinetochore recruitment by Mps1-mediated phosphorylation of Bub1 signals the spindle checkpoint.  

Science.gov (United States)

The spindle checkpoint is a conserved signaling pathway that ensures genomic integrity by preventing cell division when chromosomes are not correctly attached to the spindle. Checkpoint activation depends on the hierarchical recruitment of checkpoint proteins to generate a catalytic platform at the kinetochore. Although Mad1 kinetochore localization is the key regulatory downstream event in this cascade, its receptor and mechanism of recruitment have not been conclusively identified. Here, we demonstrate that Mad1 kinetochore association in budding yeast is mediated by phosphorylation of a region within the Bub1 checkpoint protein by the conserved protein kinase Mps1. Tethering this region of Bub1 to kinetochores bypasses the checkpoint requirement for Mps1-mediated kinetochore recruitment of upstream checkpoint proteins. The Mad1 interaction with Bub1 and kinetochores can be reconstituted in the presence of Mps1 and Mad2. Together, this work reveals a critical mechanism that determines kinetochore activation of the spindle checkpoint. PMID:24402315

London, Nitobe; Biggins, Sue

2014-01-15

149

Mad2, Bub3, and Mps1 regulate chromosome segregation and mitotic synchrony in Giardia intestinalis, a binucleate protist lacking an anaphase-promoting complex.  

Science.gov (United States)

The binucleate pathogen Giardia intestinalis is a highly divergent eukaryote with a semiopen mitosis, lacking an anaphase-promoting complex/cyclosome (APC/C) and many of the mitotic checkpoint complex (MCC) proteins. However, Giardia has some MCC components (Bub3, Mad2, and Mps1) and proteins from the cohesin system (Smc1 and Smc3). Mad2 localizes to the cytoplasm, but Bub3 and Mps1 are either located on chromosomes or in the cytoplasm, depending on the cell cycle stage. Depletion of Bub3, Mad2, or Mps1 resulted in a lowered mitotic index, errors in chromosome segregation (including lagging chromosomes), and abnormalities in spindle morphology. During interphase, MCC knockdown cells have an abnormal number of nuclei, either one nucleus usually on the left-hand side of the cell or two nuclei with one mislocalized. These results suggest that the minimal set of MCC proteins in Giardia play a major role in regulating many aspects of mitosis, including chromosome segregation, coordination of mitosis between the two nuclei, and subsequent nuclear positioning. The critical importance of MCC proteins in an organism that lacks their canonical target, the APC/C, suggests a broader role for these proteins and hints at new pathways to be discovered. PMID:25057014

Vicente, Juan-Jesus; Cande, W Zacheus

2014-09-15

150

Development of a multifunctional particle spectrometer for space radiation imaging  

Energy Technology Data Exchange (ETDEWEB)

For future exploration of the solar system, the European Space Agency (ESA) is planning missions to Mercury (BepiColombo), the Sun (SolarOrbiter) and to the moons of Jupiter and Saturn. The expected intensity of radiation during such missions is hazardous for the scientific instruments and the satellite. To extend the lifetime of the satellite and its payload a multifunctional particle spectrometer (MPS) is being developed. The basic function of the MPS is to send an alarm signal to the satellite control system during periods of high radiation. In addition the MPS is a scientific instrument that will unfold the composition of the different contributing particles on-line by the dE/dx versus E method. The energy spectrum and angular distribution of the particles will be recorded as well. This article describes the main requirements and the base line design for the MPS. A readout scheme consisting of a 32 channel ASIC from IDEAS is proposed and the signal filtering algorithm will run on a digital signal processor based on FPGA technology. Results are shown from prototype calibration studies with a proton beam.

Maddox, Erik [Cosine Research B.V, Niels Bohrweg 11, 2333 CA, Leiden (Netherlands)], E-mail: emaddox@cosine.nl; Palacios, Alex; Lampridis, Dimitris; Kraft, Stefan [Cosine Research B.V, Niels Bohrweg 11, 2333 CA, Leiden (Netherlands); Owens, Alan; Tomuta, Dana [Office of Advanced Concepts and Science Payloads, ESA/ESTEC, Noordwijk (Netherlands); Ostendorf, Reint [Kernfysisch Versneller Instituut, Zernikelaan 25, 9747 AA, Groningen (Netherlands)

2008-06-11

151

Development of a multifunctional particle spectrometer for space radiation imaging  

International Nuclear Information System (INIS)

For future exploration of the solar system, the European Space Agency (ESA) is planning missions to Mercury (BepiColombo), the Sun (SolarOrbiter) and to the moons of Jupiter and Saturn. The expected intensity of radiation during such missions is hazardous for the scientific instruments and the satellite. To extend the lifetime of the satellite and its payload a multifunctional particle spectrometer (MPS) is being developed. The basic function of the MPS is to send an alarm signal to the satellite control system during periods of high radiation. In addition the MPS is a scientific instrument that will unfold the composition of the different contributing particles on-line by the dE/dx versus E method. The energy spectrum and angular distribution of the particles will be recorded as well. This article describes the main requirements and the base line design for the MPS. A readout scheme consisting of a 32 channel ASIC from IDEAS is proposed and the signal filtering algorithm will run on a digital signal processor based on FPGA technology. Results are shown from prototype calibration studies with a proton beam

152

Development of FAME Animation System  

International Nuclear Information System (INIS)

In order to monitor an animation of magnetohydrodynamic equilibrium calculated by the FAME-II (Fast Analyzer for Magnetohydrodynamic Equilibrium-II) system, a FAME Animation System was developed. This system provides automatically the animation on workstations connected to network with the same period of JT-60U discharge sequence. Then, the system can supply the important information for JT-60U operators to determine control parameters of the succeeding discharge. This report describes the overview of the FAME Animation System. (author)

153

The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint  

OpenAIRE

M-phase checkpoints inhibit cell division when mitotic spindle function is perturbed. Here we show that the Saccharomyces cerevisiae MPS1 gene product, an essential protein kinase required for spindle pole body (SPB) duplication (Winey et al., 1991; Lauze et al., 1995), is also required for M-phase check-point function. In cdc31-2 and mps2-1 mutants, conditional failure of SPB duplication results in cell cycle arrest with high p34CDC28 kinase activity that depends on the presence of the wild-...

1996-01-01

154

Numerical simulation of sloshing with large deforming free surface by MPS-LES method  

Science.gov (United States)

Moving particle semi-implicit (MPS) method is a fully Lagrangian particle method which can easily solve problems with violent free surface. Although it has demonstrated its advantage in ocean engineering applications, it still has some defects to be improved. In this paper, MPS method is extended to the large eddy simulation (LES) by coupling with a sub-particle-scale (SPS) turbulence model. The SPS turbulence model turns into the Reynolds stress terms in the filtered momentum equation, and the Smagorinsky model is introduced to describe the Reynolds stress terms. Although MPS method has the advantage in the simulation of the free surface flow, a lot of non-free surface particles are treated as free surface particles in the original MPS model. In this paper, we use a new free surface tracing method and the key point is "neighbor particle". In this new method, the zone around each particle is divided into eight parts, and the particle will be treated as a free surface particle as long as there are no "neighbor particles" in any two parts of the zone. As the number density parameter judging method has a high efficiency for the free surface particles tracing, we combine it with the neighbor detected method. First, we select out the particles which may be mistreated with high probabilities by using the number density parameter judging method. And then we deal with these particles with the neighbor detected method. By doing this, the new mixed free surface tracing method can reduce the mistreatment problem efficiently. The serious pressure fluctuation is an obvious defect in MPS method, and therefore an area-time average technique is used in this paper to remove the pressure fluctuation with a quite good result. With these improvements, the modified MPS-LES method is applied to simulate liquid sloshing problems with large deforming free surface. Results show that the modified MPS-LES method can simulate the large deforming free surface easily. It can not only capture the large impact pressure accurately on rolling tank wall but also can generate all physical phenomena successfully. The good agreement between numerical and experimental results proves that the modified MPS-LES method is a good CFD methodology in free surface flow simulations.

Pan, Xu-jie; Zhang, Huai-xin; Sun, Xue-yao

2012-12-01

155

ISE System Development Methodology Manual  

Energy Technology Data Exchange (ETDEWEB)

The Information Systems Engineering (ISE) System Development Methodology Manual (SDM) is a framework of life cycle management guidelines that provide ISE personnel with direction, organization, consistency, and improved communication when developing and maintaining systems. These guide-lines were designed to allow ISE to build and deliver Total Quality products, and to meet the goals and requirements of the US Department of Energy (DOE), Westinghouse Savannah River Company, and Westinghouse Electric Corporation.

Hayhoe, G.F.

1992-02-17

156

HLW Disposal System Development  

International Nuclear Information System (INIS)

A KRS is suggested through design requirement analysis of the buffer and the canister which are the constituent of disposal system engineered barrier and HLW management plans are proposed. In the aspect of radionuclide retention capacity, the thickness of the buffer is determined 0.5m, the shape to be disc and ring and the dry density to be 1.6 g/cm3. The maximum temperature of the buffer is below 100 .deg. which meets the design requirement. And bentonite blocks with 5 wt% of graphite showed more than 1.0 W/mK of thermal conductivity without the addition of sand. The result of the thermal analysis for proposed double-layered buffer shows that decrease of 7 .deg. C in maximum temperature of the buffer. For the disposal canister, the copper for the outer shell material and cast iron for the inner structure material is recommended considering the results analyzed in terms of performance of the canisters and manufacturability and the geochemical properties of deep groundwater sampled from the research area with granite, salt water intrusion, and the heavy weight of the canister. The results of safety analysis for the canister shows that the criticality for the normal case including uncertainty is the value of 0.816 which meets subcritical condition. Considering nation's 'Basic Plan for Electric Power Demand and Supply' and based on the scenario of disposing CANDU spent fuels in the first phase, the disposal system that the repository will be excavated in eight phases with the construction of the Underground Research Laboratory (URL) beginning in 2020 and commissioning in 2040 until the closure of the repository is proposed. Since there is close correlation between domestic HLW management plans and front-end/back-end fuel cycle plans causing such a great sensitivity of international environment factor, items related to assuring the non-proliferation and observing the international standard are showed to be the influential factor and acceptability of HLW management plans to be the influential factor of making decision for social acceptability of nuclear power

157

HLW Disposal System Development  

Energy Technology Data Exchange (ETDEWEB)

A KRS is suggested through design requirement analysis of the buffer and the canister which are the constituent of disposal system engineered barrier and HLW management plans are proposed. In the aspect of radionuclide retention capacity, the thickness of the buffer is determined 0.5m, the shape to be disc and ring and the dry density to be 1.6 g/cm{sup 3}. The maximum temperature of the buffer is below 100 .deg. which meets the design requirement. And bentonite blocks with 5 wt% of graphite showed more than 1.0 W/mK of thermal conductivity without the addition of sand. The result of the thermal analysis for proposed double-layered buffer shows that decrease of 7 .deg. C in maximum temperature of the buffer. For the disposal canister, the copper for the outer shell material and cast iron for the inner structure material is recommended considering the results analyzed in terms of performance of the canisters and manufacturability and the geochemical properties of deep groundwater sampled from the research area with granite, salt water intrusion, and the heavy weight of the canister. The results of safety analysis for the canister shows that the criticality for the normal case including uncertainty is the value of 0.816 which meets subcritical condition. Considering nation's 'Basic Plan for Electric Power Demand and Supply' and based on the scenario of disposing CANDU spent fuels in the first phase, the disposal system that the repository will be excavated in eight phases with the construction of the Underground Research Laboratory (URL) beginning in 2020 and commissioning in 2040 until the closure of the repository is proposed. Since there is close correlation between domestic HLW management plans and front-end/back-end fuel cycle plans causing such a great sensitivity of international environment factor, items related to assuring the non-proliferation and observing the international standard are showed to be the influential factor and acceptability of HLW management plans to be the influential factor of making decision for social acceptability of nuclear power.

Choi, J. W.; Choi, H. J.; Lee, J. Y. (and others)

2007-06-15

158

Evaluation of possible failure of the mononuclear phagocyte system after total splenectomy in rats  

Directory of Open Access Journals (Sweden)

Full Text Available Young and adult Wistar rats were submitted to total splenectomy and compared to animals not submitted to any surgical manipulation in order to evaluate the phagocytic function of spleen. The animals were infected with Escherichia coli labeled with technetium-99m and killed 20 minutes later. Liver, lung, spleen and a blood clot sample were taken. No significant differences were found in the percentage of bacterial radioactivity uptake in mononuclear phagocyte system (MPS organs in young and adult splenectomized rats. However, phagocytosis index by macrophages of MPS organs was smaller in splenectomized animals than in control group. Splenectomized rats were associated with a higher blood bacterial radioactivity uptake than animals of the control group (p<0.0001 due to a larger bacterial remnant in the bloodstream. This finding suggested that some failure in the MPS occurred in the absence of the spleen, demonstrating the need to develop alternative surgical techniques for total splenectomy.

Marques Ruy Garcia

2004-01-01

159

Oncogenic B-Raf(V600E) abrogates the AKT/B-Raf/Mps1 interaction in melanoma cells.  

Science.gov (United States)

Activating B-Raf mutations that deregulate the mitogen-activated protein kinase (MAPK) pathway commonly occur in cancer. Although B-Raf(V600E) induces increased Mps1 protein contributing to centrosome amplification and chromosome instability, the regulatory mechanisms of Mps1 in melanoma cells is not fully understood. Here, we report that Mps1/AKT and B-Raf(WT)/ERK signaling form an auto-regulatory negative feedback loop in melanoma cells; notably, oncogenic B-Raf(V600E) abrogates the negative feedback loop, contributing the aberrant Mps1 functions and tumorigenesis. Our findings raise the possibility that targeting the oncogenic B-Raf and Mps1, especially when used in combination could potentially provide great therapeutic opportunities for cancer treatment. PMID:23726842

Zhang, Ling; Shi, Ruyi; He, Chanting; Cheng, Caixia; Song, Bin; Cui, Heyang; Zhang, Yanyan; Zhao, Zhiping; Bi, Yanghui; Yang, Xiaofeng; Miao, Xiaoping; Guo, Jiansheng; Chen, Xing; Wang, Jinfen; Li, Yaoping; Cheng, Xiaolong; Liu, Jing; Cui, Yongping

2013-08-28

160

Bone marrow transplantation in patients with storage diseases: a developing country experience / Transplante de medula óssea em pacientes com doença de acúmulo: experiência de um país em desenvolvimento  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese O transplante de medula óssea é uma opção terapêutica para os pacientes com doenças de acúmulo. Entre 1979 e 2002, oito pacientes, quatro femininos e quatro masculinos (entre um e 13 anos de idade) foram submetidos a este procedimento em nosso centro. Seis pacientes apresentavam mucopolissacaridose [...] (MPS I em 3; MPS III em um e MPS VI em 2), um paciente apresentava adrenoleucodistrofia e um apresentava doença de Gaucher. Cinco pacientes receberam o transplante de doador aparentado e três de doador não aparentado. Três pacientes desenvolveram doença do enxerto versus hospedeiro (dois com MPS I e um com MPS VI) e faleceram entre 37 e 151 dias após o transplante. Cinco pacientes sobreviveram entre 4 e 16 anos após o transplante. Três tiveram melhora clínica (um MPS I, um MPS VI e o paciente com doença de Gaucher), um paciente não apresentou progressão da doença (adrenoleucodistrofia) e um paciente não teve alteração da história natural da doença (MPS III). Abstract in english Bone marrow transplantation (BMT) is a therapeutic option for patients with genetic storage diseases. Between 1979 and 2002, eight patients, four females and four males (1 to 13 years old) were submitted to this procedure in our center. Six patients had mucopolysaccharidosis (MPS I in 3; MPS III in [...] one and MPS VI in 2), one had adrenoleukodystrophy (ALD) and one had Gaucher disease. Five patients had related and three unrelated BMT donor. Three patients developed graft versus host disease (two MPS I and one MPS VI) and died between 37 and 151 days after transplantation. Five patients survived 4 to 16 years after transplantation. Three patients improved (one MPS I; one MPS VI and the Gaucher disease patient), one patient had no disease progression (ALD) and in one patient this procedure did not change the natural course of the disease (MPS III).

Marcos C., Lange; Hélio A.G., Teive; André R., Troiano; Marco, Bitencourt; Vaneuza A.M., Funke; Daniela C., Setúbal; José, Zanis Neto; Carlos R., Medeiros; Lineu C., Werneck; Ricardo, Pasquini; Carmen M.S., Bonfim.

2006-03-01

161

Simulation of the QUEOS Experiment using Rigid Dynamic-Moving Particle Semi-Implicit (RD-MPS) Method  

International Nuclear Information System (INIS)

Particle dissipation and mixing in liquid are common multiphase phenomena not only in nature and but also in industrial processes. Also, It is one of important phenomena in nuclear safety analysis on severe accidents associated with the coolability of the corium debris bed, in which the characteristics of the porous corium debris bed such as local porosity distribution, debris bed configuration, debris size distribution, porous structure etc., determined by the corium jet breakup, precipitation, and mixing processes are considered to be of importance. Therefore, we developed a new computational tool, called ADDA (Analysis of Debris Dynamics and Agglomeration), based on an enhanced MPS (Moving Particle Semi-implicit) algorithm (Park, 2011) to understand the complex debris dissipation and mixing phenomena and identify the roles of the debris characteristics in the process and verified against the QUEOS experiment (Meyer, 1996; 1997) performed at FzK in Germany

162

Simulation in information systems development.  

OpenAIRE

People in organizations face problems which might be solved better by the use of computers. This study deals with the development of information systems, where computers support the solution of ill-structured problems. ... Zie: Summary

Sol, Henk Gerard

1982-01-01

163

Are Voucher Schools Putting the Squeeze on MPS? Research Brief. Volume 95, Number 1  

Science.gov (United States)

For seventeen years an underlying rationale for Milwaukee's private school voucher program has been that competition from private schools is needed to bring about improvements in Milwaukee Public Schools (MPS). However, despite an increased availability of vouchers for more eligible children than ever before, demand during the past school year did…

Public Policy Forum, 2007

2007-01-01

164

MPS [More Power Submarine] cables could be MIND [Mass Impregnated Non-Draining Cable] blowing for 1200 MW links  

Energy Technology Data Exchange (ETDEWEB)

ABB High Voltage Cables AB started the MPS (More Power Submarine cables) project in 1993 with a view to exploring new technology opportunities. The goal is to design and type test a submarine HVDC cable for a capacity of 1200 MW at 600 kV. On the day before ABB announced its success in winning the contract for the world`s largest ever submarine HVDC link project for the gigantic Bakun project in Malaysia, ABB Power Systems described progress to date at a symposium in Karlskrona. The proceedings included a test demonstration on an extruded cable which eventually broke down at a stress of over 935 kV -not in the insulation itself but in the end terminations. The electric field was in excess of 200 kV/mm which is higher than ever before reported. (UK)

Anon.

1996-07-01

165

Modular system development with pullbacks  

OpenAIRE

Two, seemingly different modular techniques for concurrent system development are investigated from a categorical perspective. A novel approach is presented in which they turn out to be merely special instances of pullback, a general categorical limit construction. Interestingly, the approach is based on truly concurrent semantics of systems.

Bednarczyk, Marek; Bernardinello, Luca; Caillaud, Benoit; Pawlowski, Wieslaw; Pomello, Lucia

2003-01-01

166

Secure Systems Development with UML  

CERN Document Server

The extension UMLsec of the Unified Modeling Language for secure systems development is presented in this text. The first part is accessible to anyone with a basic background on object-oriented systems. The second part covers the mathematical tools needed to use the UMLsec approach to verify UML specifications against security requirements.

Jürjens, Jan

2005-01-01

167

Yeast Dam1p Is Required to Maintain Spindle Integrity during Mitosis and Interacts with the Mps1p Kinase  

OpenAIRE

We have identified a mutant allele of the DAM1 gene in a screen for mutations that are lethal in combination with the mps1-1 mutation. MPS1 encodes an essential protein kinase that is required for duplication of the spindle pole body and for the spindle assembly checkpoint. Mutations in six different genes were found to be lethal in combination with mps1-1, of which only DAM1 was novel. The remaining genes encode a checkpoint protein, Bub1p, and four chaperone proteins, Sti1p, Hsc82p, Cdc37p,...

Jones, Michele H.; Bachant, Jeffrey B.; Castillo, Andrea R.; Giddings, Thomas H.; Winey, Mark

1999-01-01

168

Heating Systems Course Development Model  

Science.gov (United States)

The Advanced Technology Environmental and Energy Center (ATEEC) has provided this course development model on heating systems, including gas, fuel oil, and electric furnaces, and heat pumps. Energy conservation, efficiency options and environmental impacts are also covered. Users must download this resource for viewing, which requires a free log-in. There is no cost to download the item.

169

Overview of the control system for the IFMIF/EVEDA accelerator  

International Nuclear Information System (INIS)

The accelerator for Engineering Validation and Engineering Design Activity (EVEDA) of International Fusion Materials Irradiation Facility (IFMIF) will produce 9 MeV/125 mA CW beam. The IFMIF/EVEDA accelerator consists of Injector, RFQ, the first section of SC HWR Linac, etc. The control system for the IFMIF/EVEDA accelerator consists of Personnel Protection System (PPS), Machine Protection System (MPS), Central Control System (CCS), Local Area Network (LAN), Timing System (TS) and Local Control System (LCS). The PPS, MPS, CCS, LAN and TS have been developed by JAEA, and the LCS has been charged by EU. For these JAEA tasks, the design scenario taking into account of radio-activation, the development status and the development schedule for each accelerator components (Injector, RFQ, SC HWR linac, RF system, etc.) are presented in details. (author)

170

BNL multiparticle spectrometer (MPS) and an observation of a peak in the anti K0?+?- effective mass at 1700 MeV  

International Nuclear Information System (INIS)

The MPS is based on a large magnet, 6 ft. x 15 ft. x 4 ft. high, at 10 kG field. The detector consists of magnetostrictive and capacitive readout spark chambers with proportional wire chambers and scintillation counters for triggering. The performance of the system is described, and results from a high statistics study of the reaction K-p ? anti K0pi+?-n at 6 GeV/c are presented. A statistically significant (6 standard deviations) peak was observed in the anti K0pi+pi- effective mass at 1700 MeV

171

Development of maintenance engineering system  

International Nuclear Information System (INIS)

Department of JMTR project has developed the Maintenance Engineering System which evaluates the aging tendency of the facilities. The system is used for the repair plan and the replace period of parts, components, equipments or facilities. The system has the data-base which consists of the check data, the inspection data, the trouble data and the repair data at the JMTR since the virgin criticality. The system is utilized maintenance works and concludes the maintenance procedures for the failure components, equipments and facilities. This system has the following characteristics. (1) Anybody can operate the system as easily as word processor. (2) Data are put into by man-machine-interface. (3) The data sheets are with light color and the recognizable arrangements. (4) The system is cost-efficient using commercial personal computers and applications. The research card and the layouts of the input data sheet had been formatted. Data has been begun to be put into the system and to check its functions. The result demonstrates that the system is available for preventive maintenance at the JMTR. (author)

172

Copper vapor laser system development  

International Nuclear Information System (INIS)

High-power, high-quality, and long-life copper vapor laser (CVL) system has been developed and operated. The system is composed of a small sized CVL oscillator with high beam quality, several high-power CVL amplifiers and related sub-systems such as special resonator optics, beam shaping and propagating optics, and pulse timing controller. Further developments of high-power amplifiers are being conducted for the next R and D targets. In our latest tests, the maximum output power of 480W has been achieved by optimizing discharge circuit conditions. Major-components life-time of more than 2000 hours has been also ensured in long-term CVL amplifier operation tests. Accumulated operation time of more than 700 hours has been achieved without refilling copper source or any maintenance. (author)

173

Ubiquitin ligase Ufd2 is required for efficient degradation of Mps1 kinase.  

Science.gov (United States)

Ufd2 is a U-box-containing ubiquitylation enzyme that promotes ubiquitin chain assembly on substrates. The physiological function of Ufd2 remains poorly understood. Here, we show that ubiquitylation and degradation of the cell cycle kinase Mps1, a known target of the anaphase-promoting complex E3, require Ufd2 enzyme. Yeast cells lacking UFD2 exhibit altered chromosome stability and several spindle-related phenotypes, expanding the biological function of Ufd2. We demonstrate that Ufd2-mediated Mps1 degradation is conserved in humans. Our results underscore the significance of Ufd2 in proteolysis and further suggest that Ufd2-like enzymes regulate far more substrates than previously envisioned. PMID:22045814

Liu, Chang; van Dyk, Dewald; Choe, Vitnary; Yan, Jing; Majumder, Shubhra; Costanzo, Michael; Bao, Xin; Boone, Charles; Huo, Keke; Winey, Mark; Fisk, Harold; Andrews, Brenda; Rao, Hai

2011-12-23

174

Numerical Simulation on Direct Contact Condensation of Single Bubble in Subcooled Water using MPS method  

Science.gov (United States)

In present study, single steam bubble condensation in subcooled water have been simulated by using Moving Particle Semi-implicit(MPS) method. The liquid phase was described using moving particles and the two phase interface was set to be movable boundary which can be easily traced according to the motion of interfacial particles. The transient bubble deformation behaviors have been obtained and the results showed that both initial bubble size and subcooled degree influence bubble deformation behaviors greatly. Larger bubble experiences more severe deformation at lower liquid subcooled degree while bubble keeps near sphericity at higher liquid subcooled degree. All transient shape sequences can be found and explained properly in Grace's graphic correlation. This work exhibits some fundamental characteristics of bubble condensation using MPS-MAFL which is expected to be further adopted to evaluate other complicated bubble dynamics problems.

Tian, Wenxi; Ishiwatari, Yuki; Ikejiri, Satoshi; Oka, Yoshiaki

2010-03-01

175

Numerical analysis of jet injection mechanism of fuel-coolant interactions using MPS  

International Nuclear Information System (INIS)

The numerical method used in this study is Moving Particle Semi-implicit (MPS) method which is based on moving particles and their interactions. Grids are not necessary, so that large fluid deformation can be calculated without numerical diffusion. To understand the fundamental physics of the jet penetration, water jet injection into a pool of a denser fluid under non-boiling and isothermal conditions is calculated using the MPS method. The density ratio of the denser fluid (Fluorinert) to water is 1.88. The calculation results are compared with experiments which were conducted in the ALPHA/MUSE facility at JAERI. In three-dimensional calculation, the penetration behavior agrees with the experiment. It is found that the jet penetration process is divided to two stages and, at the first stage, the coolant jet can penetrate deeper than existing correlations of breakup length. (author)

176

Master Pump Shutdown MPS Software Quality Assurance Plan (SQAP)  

International Nuclear Information System (INIS)

The MPSS Software Quality Assurance (SQAP) describes the tools and strategy used in the development of the MPSS software. The document also describes the methodology for controlling and managing changes to the software

177

Ablation of the spindle assembly checkpoint by a compound targeting Mps1  

OpenAIRE

The spindle assembly checkpoint ensures accurate chromosome segregation by delaying anaphase initiation until all chromosomes are properly attached to the mitotic spindle. Here, we show that the previously reported c-Jun amino-terminal kinase (JNK) inhibitor SP600125 effectively disrupts spindle checkpoint function in a JNK-independent fashion. SP600125 potently inhibits activity of the mitotic checkpoint kinase monopolar spindle 1 (Mps1) in vitro and triggers efficient progression through a ...

Schmidt, M.; Budirahardja, Y.; Klompmaker, R.; Medema, R. H.

2005-01-01

178

Enzyme replacement therapy for Mucopolysaccharidosis Type I among patients followed within the MPS Brazil Network  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english Mucopolysaccharidosis type I (MPS I) is a rare lysosomal disorder caused by deficiency of alph-L-iduronidase. Few clinical trials have assessed the effect of enzyme replacement therapy (ERT) for this condition. We conducted an exploratory, open-label, non-randomized, multicenter cohort study of pati [...] ents with MPS I. Data were collected from questionnaires completed by attending physicians at the time of diagnosis (T1; n = 34) and at a median time of 2.5 years later (T2; n = 24/34). The 24 patients for whom data were available at T2 were allocated into groups: A, no ERT (9 patients; median age at T1 = 36 months; 6 with severe phenotype); B, on ERT (15 patients; median age at T1 = 33 months; 4 with severe phenotype). For all variables in which there was no between-group difference at baseline, a delta of ;±20% was considered clinically relevant. The following clinically relevant differences were identified in group B in T2: lower rates of mortality and reported hospitalization for respiratory infection; lower frequency of hepatosplenomegaly; increased reported rates of obstructive sleep apnea syndrome and hearing loss; and stabilization of gibbus deformity. These changes could be due to the effect of ERT or of other therapies which have also been found more frequently in group B. Our findings suggest MPS I patients on ERT also receive a better overall care. ERT may have a positive effect on respiratory morbidity and overall mortality in patients with MPS I. Additional studies focusing on these outcomes and on other therapies should be performed.

Alícia Dorneles, Dornelles; Louise Lapagesse de Camargo, Pinto; Ana Carolina de, Paula; Carlos Eduardo, Steiner; Charles Marques, Lourenço; Chong Ae, Kim; Dafne Dain Gandelman, Horovitz; Erlane Marques, Ribeiro; Eugênia Ribeiro, Valadares; Isabela, Goulart; Isabel C. Neves de, Souza; João Ivanildo da Costa, Neri; Luiz Carlos, Santana-da-Silva; Luiz Roberto, Silva; Márcia, Ribeiro; Ruy Pires de, Oliveira Sobrinho; Roberto, Giuglianiand; Ida Vanessa Doederlein, Schwartz.

179

Detection of localized surface deformation using a modified StaMPS algorithm  

OpenAIRE

In recent years Persistent Scatterer Interferometry (PSI) has proven to be an operational tool for measuring surface deformation with up to millimetre accuracy. The two main ideas of PSI are the use of a stack of differential radar interferograms and the restriction to a set of temporally stable radar targets, the so called Persistent Scatterers. One approach to PSI analysis is the Stanford Method for Persistent Scatterers (StaMPS). We based our work mainly on this algorithm, in which assumpt...

Schunert, A.; Even, M.; Soergel, U.; Schulz, K.

2010-01-01

180

Charged particle detector system for high rate experiments  

International Nuclear Information System (INIS)

A charged particle detector system under development at BNL for use at the Multiparticle Spectrometer (MPS) and eventually at ISABELLE is described. The object is to take full advantage of the position accuracy, resolving time and instantaneous rate capabilities of narrow anode spacing drift-proportional chambers. The system will have position resolution sigma approximately equal to 100?, time resolution approximately equal to 8 ns, detector sensitive time approximately equal to 50 ns, and consecutive particle resolving power of 40 ns per wire. It is planned to implement this system in a large system of 30,000 wires at the MPS and greater than 100,000 wires in ISABELLE experiments. Central to the development of this detector system is the production of two custom integrated circuits

181

MPS1/Mph1 phosphorylates the kinetochore protein KNL1/Spc7 to recruit SAC components.  

Science.gov (United States)

The genomic stability of all organisms depends on the precise partition of chromosomes to daughter cells. The spindle assembly checkpoint (SAC) senses unattached kinetochores and prevents premature entry to anaphase, thus ensuring that all chromosomes attach to opposite spindle poles (bi-orientation) during mitosis. MPS1 is an evolutionarily conserved protein kinase required for the SAC and chromosome bi-orientation. Yet, its primary cellular substrate has remained elusive. We show that fission yeast Mph1 (MPS1 homologue) phosphorylates the kinetochore protein Spc7 (KNL1/Blinkin homologue) at the MELT repeat sequences. This phosphorylation promotes the in vitro binding to the Bub1-Bub3 complex, which is required for kinetochore-based SAC activation (Mad1-Mad2-Mad3 localization) and chromosome alignment. Accordingly, a non-phosphorylatable spc7-12A mutation abolishes kinetochore targeting of Bub1-Bub3, whereas a phospho-mimetic spc7-12E mutation forces them to localize at kinetochores throughout the entire cell cycle, even in the absence of Mph1. Thus, MPS1/Mph1 kinase locating at the unattached kinetochores initially creates a mark, which is crucial for SAC activation and chromosome bi-orientation. This mechanism seems to be conserved in human cells. PMID:22660415

Yamagishi, Yuya; Yang, Ching-Hui; Tanno, Yuji; Watanabe, Yoshinori

2012-07-01

182

Development of teleoperated cleanup system  

International Nuclear Information System (INIS)

This report describes the development of a teleoperated cleanup system for use in a highly radioactive environment of DFDF(DUPIC Fuel Demonstration Facility) at KAERI where direct human access to the in-cell is strictly limited. The teleoperated cleanup system was designed to remotely remove contaminants placed or fixed on the floor surface of the hot-cell by mopping them with wet cloth. This cleanup system consists of a mopping slave, a mopping master and a control console. The mopping slave located at the in-cell comprises a mopping tool with a mopping cloth and a mobile platform, which were constructed in modules to facilitate maintenance. The mopping master that is an input device to control the mopping slave has kinematic dissimilarity with the mopping slave. The control console provides a means of bilateral control flows and communications between the mopping master and the mopping slave. In operation, the human operator from the out-of-cell performs a series of decontamination tasks remotely by manipulating the mopping slave located in-cell via a mopping master, having a sense of real mopping. The environmental and mechanical design considerations, and control systems of the developed teleoperated cleanup system are also described

183

Preventing the Degradation of Mps1 at Centrosomes Is Sufficient to Cause Centrosome Reduplication in Human Cells  

OpenAIRE

Supernumerary centrosomes promote the assembly of abnormal mitotic spindles in many human tumors. In human cells, overexpression of the cyclin-dependent kinase (Cdk)2 partner cyclin A during a prolonged S phase produces extra centrosomes, called centrosome reduplication. Cdk2 activity protects the Mps1 protein kinase from proteasome-mediated degradation, and we demonstrate here that Mps1 mediates cyclin A-dependent centrosome reduplication. Overexpression of cyclin A or a brief proteasome inh...

Kasbek, Christopher; Yang, Ching-hui; Yusof, Adlina Mohd; Chapman, Heather M.; Winey, Mark; Fisk, Harold A.

2007-01-01

184

Incremental value of 24-hour delayed imaging in 201Tl stress myocardial perfusion studies (MPS) with an 'early rest reinjection' protocol  

International Nuclear Information System (INIS)

Full text: One hundred patients (pts) undergoing stress MPS had 24 h imaging for fixed defects at 4 h delayed imaging. 53 had prior myocardial infarction (MI) and 71 were males. Stress employed isotonic exercise with dipyridamole (0.56 mg kg-1) infusion in 57 pts, exercise alone in 33 and dipyridamole alone in 10. All pts with stress defects had rest-reinjection of 40 MBq of 201Tl after stress imaging had been completed, and most had sublingual nitrate therapy 10 min before reinjection. MPS from the 100 pts (15% of total) were read without clinical data, using a 20 segment scoring system. 51 pts showed -2 segments improvement between 4 and 24 h scores, but 22 pts had shown reversibility between stress and 4 h imaging and the further change did not alter interpretation. The other 29 pts (group A) showed clinically important change in 24 h scores, leaving 71 pts without clinical change (group B). Segmental improvement between 4 and 24 h in group A was 4.62 ± 2.18 and 1.18 ± 1.48 in group B (P = 0.02). Group A stress defect scores were not greater (10.90 ± 3.60) or more severe (3.72 ± 3.06) than in group B (8.92 ± 4.34 and 2.79 ± 3.11); 18 group A pts had MI compared with 38 group B pts. No significant correlation was found between improved 4-24 h scores and parameters of stress-LV dysfunction. There is benefit from 24 h, 201TI MPS in patients with persisting 4 h defects, despite early rest-reinjection and acute nitrate therapyction and acute nitrate therapy

185

Crystal structure of the catalytic domain of the mitotic checkpoint kinase Mps1 in complex with SP600125.  

Science.gov (United States)

Chromosomal instability can result from defective control of checkpoints and is associated with malignant cell growth. Monopolar spindle 1 (Mps1) is a dual-specificity protein kinase that has important roles in the prevention of aneuploidy during the cell cycle and might therefore be a potential target for new therapeutic agents in the treatment of cancer. To gain insights into the molecular mechanism of Mps1 inhibition by small molecules, we determined the x-ray structure of Mps1, both alone and in complex with the ATP-competitive inhibitor SP600125. Mps1 adopts a classic protein kinase fold, with the inhibitor sitting in the ATP-binding site where it is stabilized by hydrophobic interactions. We identified a secondary pocket, not utilized by SP600125, which might be exploited for the rational design of specific Mps1 inhibitors. These structures provide important insights into the interaction of this protein kinase with small molecules and suggest potential mechanisms for Mps1 regulation. PMID:18480048

Chu, Matthew L H; Chavas, Leonard M G; Douglas, Kenneth T; Eyers, Patrick A; Tabernero, Lydia

2008-08-01

186

Development of pipe layout system  

International Nuclear Information System (INIS)

In the plant design carried out so far, the process up to final drawings has been the repetition of the correction of drawings. This is because the space as the object of design is finite, and it is difficult to lay many pipes efficiently. Especially in nuclear power plants, the quantity of materials required for ensuring the safety and quality control is enormous, and only the skilled engineers having rich experience have become unable to deal with it. The model engineering using plastic models has been adopted, but still there are problems. In order to solve this problem, the development of the system for unitarily managing the various design information of plants with a computer, checking up various design with this information, automatically outputting design drawings and management data, and heightening the quality of design, synchronizing the progress, increasing the speed and saving the labor of design was carried out. This system is versatile and can be used for all plants. The emphasis in the development was placed on compact data structure, rapid picture processing and easy operation. The present status of design and the automation, the basic design of the system, the function of the system, the internal expression of models, the method of picture processing, and the results of application are reported. (Kako, I.)

187

Development of safeguards system simulator  

International Nuclear Information System (INIS)

Due to a large plutonium (Pu) throughput and high burn-up fuel in an advanced reprocessing plant, we have the responsibility to undertake the inevitable burden of nuclear material accountancy (NMA) to meet the International Atomic Energy Agency (IAEA) safeguards criteria. A large amount of sampling analysis and inspectors' activities result in a great cost in facility operation to verify no concealment and undeclared use of Pu. In addition to NMA, containment and surveillance (C/S), process monitoring (PM), and curium (Cm) balance have been used for the safeguards activities to complement NMA. However, except for NMA, any mathematical or regulatory formalism in the safeguards measures have not been presented so far, therefore it is difficult to evaluate the cost-effective performance of the safeguards system. In order to design an advanced safeguards system for the fast reactor fuel cycle, the JAEA has started to develop a safeguards system simulator. A NMA core in the simulator is composed of a near-real-time accounting (NRTA) code which had been already developed and applied to investigate the NMA characteristics of JAEA facilities. A 'multivariate and multi-scale core' is based on a multivariate mathematical analysis combined with a multi-scale statistical process analysis making use of a wavelet decomposition forms safeguards envelope, which provides a control and monitoring system logic. Multi-scale principle component analysis of the core had been applied to 'maalysis of the core had been applied to 'material unaccounted for' (MUF). A concept of multiple optimization core is proposed as the safeguards formalism, with probabilistic risk analysis and cost-performance characteristics of the safeguards system, is discussed in the presentation. Flow meter and non-destructive analysis can be more broadly applied to the system in a cost-effective manner. A virtual design and objective-driven model will be developed in the simulator in the future to support an effective safeguards design and to develop a walk-through' virtual plant model. (author)

188

Reciprocating Feed System Development Status  

Science.gov (United States)

The reciprocating feed system (RFS) is an alternative means of providing high pressure propellant flow at low cost and system mass, with high fail-operational reliability. The RFS functions by storing the liquid propellants in large, low-pressure tanks and then expelling each propellant through two or three small, high-pressure tanks. Each RFS tank is sequentially filled, pressurized, expelled, vented, and refilled so as to provide a constant, or variable, mass flow rate to the engine. This type of system is much lighter than a conventional pressure fed system in part due to the greatly reduced amount of inert tank weight. The delivered payload for an RFS is superior to that of conventional pressure fed systems for conditions of high total impulse and it is competitive with turbopump systems, up to approximately 2000 psi. An advanced version of the RFS uses autogenous pressurization and thrust augmentation to achieve higher performance. In this version, the pressurization gases are combusted in a small engine, thus making the pressurization system, in effect, part of the propulsion system. The RFS appears to be much less expensive than a turbopump system, due to reduced research and development cost and hardware cost, since it is basically composed of small high- pressure tanks, a pressurization system, and control valves. A major benefit is the high reliability fail-operational mode; in the event of a failure in one of the three tank-systems, it can operate on the two remaining tanks. Other benefits include variable pressure and flow rates, ease of engine restart in micro-gravity, and enhanced propellant acquisition and control under adverse acceleration conditions. We present a system mass analysis tool that accepts user inputs for various design and mission parameters and calculates such output values payload and vehicle weights for the conventional pressure fed system, the RFS, the Autogenous Pressurization Thrust Augmentation (APTA) RFS, and turbopump systems. Using this tool, a preliminary design of a representative crew exploration vehicle (CEV) has been considered. The design parameters selected for a representative system were modeled after the orbital maneuvering system (OMS) on the Shuttle Orbiter, with an increase of roughly a factor of ten in the delta- V capability and a greater thrust (30,000 lbs, vs. 12,000 lbs). Both storable and cryogenic propellants were considered. Results show that a RFS is a low mass alternative to conventional pressure fed systems, with a substantial increase in payload capability and that it is weight-competitive with turbopump systems at low engine pressure (a few hundred psi); at high engine pressures, the APTA RFS appears to offer the highest payload. We also present the status of the RFS test bed fabrication, assembly, and checkout. This test bed is designed to provide flow rates appropriate for engines in the roughly 10,000 to 30,000 lb thrust range.

Trewek, Mary (Technical Monitor); Blackmon, James B.; Eddleman, David E.

2005-01-01

189

Expert system development (ESD) shell  

International Nuclear Information System (INIS)

An Expert System Development (ESD) Shell design implementation is desribed in detail. The shell provides high-level generic facilities for Knowledge Representation (KR) and inferencing and tools for developing user interfaces. Powerful set of tools in the shell relieves much of the programming burden in the ES development. The shell is written in PROLOG under IBM PC/AT. KR facilities are based on two very powerful formalisms namely, frames and rules. Inference Engine (IE) draws most of its power from unification and backward reasoning strategy in PROLOG. This basic mechanism is enhanced further by incorporating both forward and backward chaining of rules and frame-based inferencing. Overall programming style integrates multiple paradigms including logic, object oriented, access-oriented and imperative programming. This permits ES designer a lot of flexibility in organizing inference control. Creation and maintainance of knowledge base is a major activity. The shell, therefore, provides number of facilities to simplify these tasks. Shell design also takes note of the fact that final success of any system depends on end-user satisfaction and hence provides features to build use-friendly interfaces. The shell also provides a set of interfacing predicates so that it can be embedded within any PROLOG program to incorporate functionalilty of the shell in the user program. (author). 10 refs., 8 figs

190

KSTAR RF heating system development  

International Nuclear Information System (INIS)

Design, high-voltage test, and installation of 6 MW ICRF heating system for KSTAR is completed. The antenna demonstrated satisfactory standoff at high voltages up to 41 kV for 300 sec. The result indicates good power handling capabilities of the antenna as high as 10 MW/m2. This power density is equivalent to RF power coupling of 6 MW into a 4 ?/m target plasma, and is typical of advanced tokamak heating scenarios. In addition, vacuum feed through, DC break, and liquid stub developed for 300 sec operation are installed, as well as a 2 MW, 30-60MHz transmitter. The transmitter successfully produced output powers of 600 kW continuously, 1.5?1.8 MW for 300 sec, and 2 MW for 100 msec or shorter pulses. A realtime control system based on DSP and EPICS is developed, installed, and tested on the ICRF system. Initial results from feasibility study indicate that the present antenna and the transmission lines could allow load-resilient operation on KSTAR. Until the KSTAR tokamak start to produce plasmas in 2008, however, hands-on operational experiences are obtained from participating in ICRF heating experiments at ASDEX and DIII-D tokamaks arranged through international cooperation

191

KSTAR RF heating system development  

Energy Technology Data Exchange (ETDEWEB)

Design, high-voltage test, and installation of 6 MW ICRF heating system for KSTAR is completed. The antenna demonstrated satisfactory standoff at high voltages up to 41 kV for 300 sec. The result indicates good power handling capabilities of the antenna as high as 10 MW/m2. This power density is equivalent to RF power coupling of 6 MW into a 4 {omega}/m target plasma, and is typical of advanced tokamak heating scenarios. In addition, vacuum feed through, DC break, and liquid stub developed for 300 sec operation are installed, as well as a 2 MW, 30-60MHz transmitter. The transmitter successfully produced output powers of 600 kW continuously, 1.5{approx}1.8 MW for 300 sec, and 2 MW for 100 msec or shorter pulses. A realtime control system based on DSP and EPICS is developed, installed, and tested on the ICRF system. Initial results from feasibility study indicate that the present antenna and the transmission lines could allow load-resilient operation on KSTAR. Until the KSTAR tokamak start to produce plasmas in 2008, however, hands-on operational experiences are obtained from participating in ICRF heating experiments at ASDEX and DIII-D tokamaks arranged through international cooperation.

Kwak, J. G.; Kim, S. K.; Hwang, C. K. (and others)

2007-10-15

192

Computer aided training system development  

International Nuclear Information System (INIS)

The first three phases of Training System Development (TSD) -- job and task analysis, curriculum design, and training material development -- are time consuming and labor intensive. The use of personal computers with a combination of commercial and custom-designed software resulted in a significant reduction in the man-hours required to complete these phases for a Health Physics Technician Training Program at a nuclear power station. This paper reports that each step in the training program project involved the use of personal computers: job survey data were compiled with a statistical package, task analysis was performed with custom software designed to interface with a commercial database management program. Job Performance Measures (tests) were generated by a custom program from data in the task analysis database, and training materials were drafted, edited, and produced using commercial word processing software

193

Development of targeted radiotherapy systems  

International Nuclear Information System (INIS)

Conventional or external beam radiotherapy, has been a viable alternative for cancer treatment. Although this technique is effective, its use is limited if the patient has multiple malignant lesions (metastases). An alternative approach is based on the design of radiopharmaceuticals that, to be administered in the patient, are directed specifically toward the target cell producing a selective radiation delivery. This treatment is known as targeted radiotherapy. We have summarized and discussed some results related to our investigations on the development of targeted radiotherapy systems, including aspects of internal dosimetry

194

Development of insulin delivery systems.  

Science.gov (United States)

Delivery system of insulin is vital for its acceptance and adherence to therapy for achieving the glycemic targets. Enormous developments have occurred in the delivery system of insulin during the last twenty years and each improvement was aimed at two common goals: patients convenience and better glycemic control. Till to date, the various insulin delivery systems are: syringes/vials, injection aids, jet injectors, transmucosal delivery, transdermal delivery, external insulin infusion pump, implantable insulin pumps, insulin pens and insulin inhalers. Syringe/vial is the oldest and conventional method, still widely used and relatively cheaper. Modern plastic syringes are disposable, light weight with microfine needle for patients convenience and comfort. Oral route could be the most acceptable and viable, if the barriers can be overcome and under extensive trial. Insulin pen device is an important milestone in the delivery system of insulin as it is convenient, discrete, painless, attractive, portable with flexible life style and improved quality of life. More than 80% of European diabetic patients are using insulin pen. Future digital pen will have better memory option, blood glucose monitoring system, insulin dose calculator etc. Insulin infusion pump is a good option for the children, busy patients with flexible lifestyle and those who want to avoid multiple daily injections. Pulmonary route of insulin delivery is a promising, effective, non-invasive and acceptable alternative method. Exubera, the world first insulin inhaler was approved by FDA in 28 January 2006. But due to certain limitations, it has been withdrawn from the market in October 2007. The main concern of inhaled insulin are: long term pulmonary safety issues, cost effectiveness and user friendly device. In future, more acceptable and cost effective insulin inhaler will be introduced. Newer avenues are under extensive trial for better future insulin delivery systems. PMID:18285745

Siddiqui, N I; Siddiqui, Ni; Rahman, S; Nessa, A

2008-01-01

195

Compact Microscope Imaging System Developed  

Science.gov (United States)

The Compact Microscope Imaging System (CMIS) is a diagnostic tool with intelligent controls for use in space, industrial, medical, and security applications. The CMIS can be used in situ with a minimum amount of user intervention. This system, which was developed at the NASA Glenn Research Center, can scan, find areas of interest, focus, and acquire images automatically. Large numbers of multiple cell experiments require microscopy for in situ observations; this is only feasible with compact microscope systems. CMIS is a miniature machine vision system that combines intelligent image processing with remote control capabilities. The software also has a user-friendly interface that can be used independently of the hardware for post-experiment analysis. CMIS has potential commercial uses in the automated online inspection of precision parts, medical imaging, security industry (examination of currency in automated teller machines and fingerprint identification in secure entry locks), environmental industry (automated examination of soil/water samples), biomedical field (automated blood/cell analysis), and microscopy community. CMIS will improve research in several ways: It will expand the capabilities of MSD experiments utilizing microscope technology. It may be used in lunar and Martian experiments (Rover Robot). Because of its reduced size, it will enable experiments that were not feasible previously. It may be incorporated into existing shuttle orbiter and space station experiments, including glove-box-sized experiments as well as ground-based experiments.

McDowell, Mark

2001-01-01

196

Development of controlled drilling system  

International Nuclear Information System (INIS)

In Japan, the soft sedimentary rock of the Neogene tertiary is being focused as a host rock for the High Level Radioactive Waste (HLW) disposal. Especially, the soft sedimentary rock at the offshore, region is thought to be one of the best candidates, since there is no driving force of the underground water. The measurement and logging in the bore hole in order to check the hydro-geological and geomechanical conditions of the host rock is a very important way to examine the potentially of the disposal candidates. The CRIEPI (Central Research Institute of Electric Power Industry) has been conducting the project about the controlled drilling technology and the measurement and logging technologies in its borehole. In 2000, as the beginning year of the project, we made the conceptual design of the drilling and measuring systems, and made key tools concerning each technology on an experimental basis. We have been developing sub tools constructing drilling and measuring systems since 2000, and applying these systems to the Horonobe site recent 5 years. We will briefly report the outline of the system and the results of drilling and measurement that were carried out at the Horonobe site. (author)

197

Exercise tolerance test (ett) or myocardial perfusion scan (mps) - what to choose in patients of ischaemic heart disease (ihd)  

International Nuclear Information System (INIS)

Objective: To evaluate the validity of exercise tolerance test (ETT) with treadmill exercise in the diagnosis and follow-up of ischaemic heart disease (IHD), taking myocardial perfusion scan (MPS) as standard. Study Design: Retrospective, validation study. Place and Duration of Study: Nuclear Medical Centre (NMC) Armed Forces Institute of Pathology (AFIP), Rawalpindi, Pakistan, from 1 January to 31 December 2009. Patients and Methods: One hundred and nineteen patients (88 males, 31 females), referred for MPS; were selected through non-probability, consecutive sampling. Patients of all ages and gender, fit to undertake treadmill exercise, were included. Patients with contraindications to ETT, like unstable angina, conduction abnormalities, etc., or those who had taken a beta blocker within the preceding 24 hours, were excluded. ETT through treadmill exercise was done, followed by MPS with single photon emission computed tomography (SPECT) technique, using Thallium-201 or Technetium-99 m 2-methoxy-isobutyl-isonitrile (MIBI). ETT was interpreted as positive or negative for ischaemia, with borderline changes considered positive. MPS was interpreted as positive or negative for ischaemia. Validity of ETT was evaluated in terms of sensitivity (Sn), specificity (Sp), and positive and negative predictive value (PPV and NPV), taking MPS as standard. Results: Sensitivity of ETT was found to be 77.5% and specificity was 43.6%. PPV was 73.8% and NPV was 48.6%. Out of a total (n) of 119 patients, true positive (TP) cases were 62, true negative (TN) 17, false positive (FP) 22 and false negative (FN) 18. Conclusions: ETT is an acceptably sensitive but non-specific test for evaluating myocardial ischaemia, with adequate PPV but low NPV, when validating it against MPS. Replacing the MPS with ETT, in the diagnosis and follow-up of IHD, is thus, not prudent. ETT can be useful as a screening test. (author)

198

AGING SYSTEM DESIGN DEVELOPMENT STRATEGY  

International Nuclear Information System (INIS)

This plan provides an overview, work to date, and the path forward for the design development strategy of the Aging cask for aging commercial spent nuclear fuel (CSNF) at the Yucca Mountain Project (YMP) repository site. Waste for subsurface emplacement at the repository includes US Department of Energy (DOE) high-level radioactive waste (HLW), DOE SNF, commercial fuel in dual-purpose canisters (DPCs), uncanistered bare fuel, naval fuel, and other waste types. Table 1-1 lists the types of radioactive materials that may be aged at YMP, and those materials that will not be placed in an aging cask or module. This plan presents the strategy for design development of the Aging system. The Aging system will not handle naval fuel, DOE HLW, MCOs, or DOE SNF since those materials will be delivered to the repository in a state and sequence that allows them to be placed into waste packages for emplacement. Some CSNF from nuclear reactors, especially CSNF that is thermally too hot for emplacement underground, will need to be aged at the repository

199

ADASAGE, ADA Application Development System  

International Nuclear Information System (INIS)

1 - Description of program or function: ADASAGE is an application development system designed to facilitate rapid and professional construction of applications written in Ada on microcomputers. ADASAGE applications may vary in size from small to large multi-program systems. ADASAGE consists of a collection of re-usable libraries for database management and form and report processing utilities having the following capabilities: basic universal type and function definitions; sequential file input/output; terminal and file input/output; DOS system command execution; data movement and fill; string manipulation; math libraries; bit manipulation; a relational database utility; data validation; menu form and window procedures; report generation; sort/merge, time, and date functions; sound production; editing; and index rebuilding. Each of the capabilities is integrated to allow the development of an efficient system. As an application is designed and developed, the desired ADASAGE capabilities are chosen and included along with any requirements unique to that application. 2 - Method of solution: All ADASAGE applications which use the database, forms (windows, menus, etc.), or reporting functions require a file with a suffix of .DFL. This file contains the database schema, the various forms and windows, and report definitions. The THOR editor is used to create and maintain the .DFL file. This editor operates on a file with the suffix .SRC and creates and edits schemes, forms,.SRC and creates and edits schemes, forms, and report formats and compile the .SRC file into the .DFL file used by the application. The application will have unique requirements not satisfied by the selected utilities of ADASAGE. The code for these along with the code necessary to import and use the selected ADASAGE utilities constitutes the programmed application. The completed application system will contain the .DFL file produced by the THOR editor, the required ADASAGE utilities, and the programmed application. During the course of normal database development and use, restructuring and/or rebuilding of database files may be required if the schema for a record is modified (new fields are added, changed, or deleted and new keys selected, etc.), or if the index file for a relation becomes damaged or is destroyed. Program REBUILD performs this task. The rebuilding process is invoked by supplying both an old .DFL file name identifying the schema definition under which the current data was written and a current .DFL file name identifying the new schema definition to which the current database must be changed. REBUILD compares the old and current schema definitions for a relation, adjusts the database files accordingly, and re-tags the database files with the new version so that access with the new schema is allowed. The index file for the relation is then rebuilt, and any unused space within the database files removed. 3 - Restrictions on the complexity of the problem: Maxima for each ADASAGE database are: 4,294,967,000 records (tuples) per record size; 32,000 bytes record (tuple) size; 32,000 fixed-length field (attribute size); 4,294,967,000 variable-length field (attribute) size; 1,000 relations (flat files); 1,000 joined relations; 1,000 views; 500 fields (attributes) per relation; 500 keyed fields per relation; 6,550 forms (windows); 55 significant digits in a number. The user's operating system or hardware may have more stringent limits than these

200

Degradation of the Human Mitotic Checkpoint Kinase Mps1 Is Cell Cycle-regulated by APC-cCdc20 and APC-cCdh1 Ubiquitin Ligases*  

OpenAIRE

Mps1 is a dual specificity protein kinase with key roles in regulating the spindle assembly checkpoint and chromosome-microtubule attachments. Consistent with these mitotic functions, Mps1 protein levels fluctuate during the cell cycle, peaking at early mitosis and abruptly declining during mitotic exit and progression into the G1 phase. Although evidence in budding yeast indicates that Mps1 is targeted for degradation at anaphase by the anaphase-promoting complex (APC)-cCdc20 complex, little...

Cui, Yongping; Cheng, Xiaolong; Zhang, Ce; Zhang, Yanyan; Li, Shujing; Wang, Chuangui; Guadagno, Thomas M.

2010-01-01

201

Identification, expression, and biochemical characterization of N-acetylgalactosamine-4-sulfatase mutations and relationship with clinical phenotype in MPS-VI patients.  

OpenAIRE

Maroteaux-Lamy syndrome, or mucopolysaccharidosis type VI (MPS-VI), is a lysosomal storage disorder characterized by the defective degradation of dermatan sulfate due to the deficiency of N-acetylgalactosamine-4-sulfatase (4S). The clinical severity of MPS-VI ranges in a continuum from mildly affected to severely affected patients. Mutations in MPS-VI patient samples were identified by chemical cleavage and direct DNA sequencing of PCR products derived from patient cDNA. Five amino acid subst...

Litjens, T.; Brooks, D. A.; Peters, C.; Gibson, G. J.; Hopwood, J. J.

1996-01-01

202

Characterization of a putative spindle assembly checkpoint kinase Mps1, suggests its involvement in cell division, morphogenesis and oxidative stress tolerance in Candida albicans.  

Science.gov (United States)

In Saccharomyces cerevisiae MPS1 is one of the major protein kinase that governs the spindle checkpoint pathway. The S. cerevisiae structural homolog of opportunistic pathogen Candida albicans CaMPS1, is indispensable for the cell viability. The essentiality of Mps1 was confirmed by Homozygote Trisome test. To determine its biological function in this pathogen conditional mutant was generated through regulatable MET3 promoter. Examination of heterozygous and conditional (+Met/Cys) mps1 mutants revealed a mitosis specific arrest phenotype, where mutants showed large buds with undivided nuclei. Flowcytometry analysis revealed abnormal ploidy levels in mps1 mutant. In presence of anti-microtubule drug Nocodazole, mps1 mutant showed a dramatic loss of viability suggesting a role of Mps1 in Spindle Assembly Checkpoint (SAC) activation. These mutants were also defective in microtubule organization. Moreover, heterozygous mutant showed defective in-vitro yeast to hyphae morphological transition. Growth defect in heterozygous mutant suggest haploinsufficiency of this gene. qRT PCR analysis showed around 3 fold upregulation of MPS1 in presence of serum. This expression of MPS1 is dependent on Efg1 and is independent of other hyphal regulators like Ras1 and Tpk2. Furthermore, mps1 mutants were also sensitive to oxidative stress. Heterozygous mps1 mutant did not undergo morphological transition and showed 5-Fold reduction in colony forming units in response to macrophage. Thus, the vital checkpoint kinase, Mps1 besides cell division also has a role in morphogenesis and oxidative stress tolerance, in this pathogenic fungus. PMID:25025778

Kamthan, Mohan; Nalla, Vijaya Kumar; Ruhela, Deepa; Kamthan, Ayushi; Maiti, Protiti; Datta, Asis

2014-01-01

203

PP2A-B56 opposes Mps1 phosphorylation of Knl1 and thereby promotes spindle assembly checkpoint silencing.  

Science.gov (United States)

The spindle assembly checkpoint (SAC) monitors correct attachment of chromosomes to microtubules, an important safeguard mechanism ensuring faithful chromosome segregation in eukaryotic cells. How the SAC signal is turned off once all the chromosomes have successfully attached to the spindle remains an unresolved question. Mps1 phosphorylation of Knl1 results in recruitment of the SAC proteins Bub1, Bub3, and BubR1 to the kinetochore and production of the wait-anaphase signal. SAC silencing is therefore expected to involve a phosphatase opposing Mps1. Here we demonstrate in vivo and in vitro that BubR1-associated PP2A-B56 is a key phosphatase for the removal of the Mps1-mediated Knl1 phosphorylations necessary for Bub1/BubR1 recruitment in mammalian cells. SAC silencing is thus promoted by a negative feedback loop involving the Mps1-dependent recruitment of a phosphatase opposing Mps1. Our findings extend the previously reported role for BubR1-associated PP2A-B56 in opposing Aurora B and suggest that BubR1-bound PP2A-B56 integrates kinetochore surveillance and silencing of the SAC. PMID:25246613

Espert, Antonio; Uluocak, Pelin; Bastos, Ricardo Nunes; Mangat, Davinderpreet; Graab, Philipp; Gruneberg, Ulrike

2014-09-29

204

MEASUREMENT PROCESS OF SOFTWARE DEVELOPMENT PROJECTS FOR SUPPORTING STRATEGIC BUSINESS OBJECTIVES IN SOFTWARE DEVELOPING COMPANIES  

Directory of Open Access Journals (Sweden)

Full Text Available Software developing companies work in a competitive market and are often challenged to make business decisions with impact on competitiveness. Models accessing maturity for software development processes quality, such as CMMI and MPS-BR, comprise process measurements systems (PMS. However, these models are not necessarily suitable to support business decisions, neither to achieve strategic goals. The objective of this work is to analyze how the PMS of software development projects could support business strategies for software developing companies. Results taken from this work show that PMS results from maturity models for software processes can be suited to help evaluating operating capabilities and supporting strategic business decisions.

Sandra Lais Pedroso

2013-08-01

205

Efficacy of StaMPS technique for monitoring surface deformation in L'Aquila, Italy  

Science.gov (United States)

This research work investigates the efficacy of the Stanford Method for Persistent Scatterer Interferometry (StaMPS) in measuring the surface deformation over the L'Aquila region, Italy just before an event of earthquake of magnitude Mw 6.3 by using seven descending Envisat C-Band ASAR images. The results show that the StaMPS technique successfully extracted sufficient number of Persistent Scatterers (PS) to derive a one dimensional (1D) time series displacement map which shows the deformation rates up to 59 mm/year in the satellite Line of Sight (LOS) direction and 50.8 mm/year in the direction opposite to the satellite LOS. Further, several deformation gradients are also observed from this map which indicate the occurrence of multiple crustal movement mechanism. Another dataset of 14 ASAR images is processed covering a time period before and after the earthquake in the study area to validate the results obtained by the previous dataset. We observed that the generated displacement map follows the deformation characteristics of the earlier displacement map in terms of magnitude and surface movement. We conclude that the generated displacement maps validate the presence of a normal fault mechanism with a tectonic process stretching in a NW-SE direction as predicted by earlier research studies.

Tiwari, A.; Dwivedi, R.; Narayan, A. B.; Dikshit, O.; Singh, A. K.

2014-11-01

206

Mps1 and Ipl1/Aurora B act sequentially to correctly orient chromosomes on the meiotic spindle of budding yeast.  

Science.gov (United States)

The conserved kinases Mps1 and Ipl1/Aurora B are critical for enabling chromosomes to attach to microtubules so that partner chromosomes will be segregated correctly from each other, but the precise roles of these kinases have been unclear. We imaged live yeast cells to elucidate the stages of chromosome-microtubule interactions and their regulation by Ipl1 and Mps1 through meiosis I. Ipl1 was found to release kinetochore-microtubule (kMT) associations after meiotic entry, liberating chromosomes to begin homologous pairing. Surprisingly, most chromosome pairs began their spindle interactions with incorrect kMT attachments. Ipl1 released these improper connections, whereas Mps1 triggered the formation of new force-generating microtubule attachments. This microtubule release and reattachment cycle could prevent catastrophic chromosome segregation errors in meiosis. PMID:23371552

Meyer, Régis E; Kim, Seoyoung; Obeso, David; Straight, Paul D; Winey, Mark; Dawson, Dean S

2013-03-01

207

Sample preparation of membrane proteins suitable for solid-state MAS NMR and development of assignment strategies  

OpenAIRE

Although the basic structure of biological membranes is provided by the lipid bilayer, most of the specific functions are carried out by membrane proteins (MPs) such as channels, ion-pumps and receptors. Additionally, it is known, that mutations in MPs are directly or indirectly involved in many diseases. Thus, structure determination of MPs is of major interest not only in structural biology but also in pharmacology, especially for drug development. Advances in structural biology of membrane...

Hiller, Matthias

2009-01-01

208

APPROACHING DEVELOPMENT IN LOGISTIC INFORMATION SYSTEMS  

OpenAIRE

The introduction of technology into modern defence necessitates integrated computerized information systems to render effective and efficient logistic support. Traditional information system development does not ensure attainment of use and time scale requirements in the continuously developing environment of logistics. This paper describes current approaches to the development of logistic information systems.

Buys, Louis F.

2012-01-01

209

APPROACHING DEVELOPMENT IN LOGISTIC INFORMATION SYSTEMS  

Directory of Open Access Journals (Sweden)

Full Text Available The introduction of technology into modern defence necessitates integrated computerized information systems to render effective and efficient logistic support. Traditional information system development does not ensure attainment of use and time scale requirements in the continuously developing environment of logistics. This paper describes current approaches to the development of logistic information systems.

Louis F Buys

2012-01-01

210

STUDI DAYA HAMBAT IN VITRO ANTI MPS ECTO CIK (MAYOR PHYSIOLOGICAL PROTEIN SUBSTRAT TERHADAP VIABILITAS SPERMATOZOA KAMBING DAN DOMBA  

Directory of Open Access Journals (Sweden)

Full Text Available Untuk menuju suatu penemuan tentang vaksin kontrasepsi bagi pria, diperlukan penelitian dasar mengenai hal tersebut. Sebagai langkah awal dilakukan uji hambatan Anti MPS ecto CIK terhadap viabilitas spermatozoa kambing dan domba, sedangkan dari penelitian pendahuluan diketahui bahwa anti MPS dari ecto-CIK ini mampu bereaksi silang dengan spermatozoa domba, dan sapi. Berdasarkan hal tersebut peneliti tertarik untuk mengetahui seberapa besar peranan anti MPS ecto CIK dalam menghambat viabilitas spermatozoa kambing dan domba secara in vitro.Tujuan dari penelitian ini adalah mengetahui seberapa besar peranan anti MPS ecto CIK dengan pemberian perlakuan konsentrasi dan lama inkubasi serta interaksi kedua perlakuan dalam menghambat viabilitas spermatozoa kambing dan domba. Rancangan penelitian yang digunakan adalah rancangan acak lengkap (RAL dengan pola faktorial yang terdiri atas 2 faktor utama, faktor pertama yaitu: dosis pengenceran, 0µl, 5µl, 10µl, dan 15µl, dan faktor kedua yaitu: lama inkubasi, yaitu 5 menit, 30 menit, 60 menit, dan 120 menit, masing-masing 6 kali ulangan. Data viabilitas spermatozoa kambing dan domba dianalisis dengan Uji one way ANOVA, jika hasil dari analisis tersebut terdapat pengaruh yang nyata maka akan dilanjutkan dengan Uji Jarak Berganda Duncan dengan taraf signifikansi 5% (0,05.Pemberian perlakuan anti MPS dari ecto CIK membran spermatozoa kambing dengan konsentrasi dan 0 µl, 5 µl, 10 µl, 15 µl dan lama inkubasi 5 menit, 30 menit, 60 menit dan 120 menit berpengaruh signifikan dalam menghambat viabilitas spermatozoa kambing dan domba. Pada perlakuan anti MPS ecto CIK dengan konsentrasi 15 µl dan lama inkubasi 120 menit merupakan perlakuan yang paling optimal dalam menghambat viabilitas spermatozoa kambing (45,50 ± 11,16%; 44,87 ± 9,40% dan domba (55,54 ± 18,87%; 40,58 ± 13,20%. Interaksi pemberian perlakuan konsentrasi dan lama inkubasi anti MPS ecto CIK pada konsentrasi 15 µl dan lama inkubasi 120 menit anti MPS ecto CIK paling berpengaruh dalam menghambat viabilitas spermatozoa domba (26,83 ± 8,70%, sedangkan pada kambing tidak berpengaruh.

Bayyinatul Muchtaromah

2009-03-01

211

Developing Information Systems for Competitive Intelligence Support.  

Science.gov (United States)

Discusses issues connected with developing information systems for competitive intelligence support; defines the elements of an effective competitive information system; and summarizes issues affecting system design and implementation. Highlights include intelligence information; information needs; information sources; decision making; and…

Hohhof, Bonnie

1994-01-01

212

Building and developing the ARC system  

OpenAIRE

ARC system is an electronics test system for testing silicon detectors in LHC experiment. The first objective in thesis was to construct and develop the ARC system. The ARC system collects measurements data from detectors and controls the electronics. The ARC system consisted of two parts: the ARC electronics and ARCS software. The second part of the thesis was to develop a program, which was able to analyse data collected with the ARC system. The goal in the thesis was to make...

Nyka?nen, Mikko

2010-01-01

213

Development of autonomous operation system  

International Nuclear Information System (INIS)

To enhance operation reliability of nuclear plants by removing human factors, study on an autonomous operation system has been carried out to substitute artificial intelligence (AI) for plant operators and, in addition, traditional controllers used in existing plants. For construction of the AI system, structurization of knowledge on the basis of the principles such as physical laws, function and structure of relevant objects and generalization of problem solving process are intended. A hierarchical distributed cooperative system configuration in employed because it is superior from the viewpoint of dynamical reorganization of system functions. This configuration is realized by an object-oriented multi-agent system. Construction of a prototype system was planned and the conceptual design was made for FBR plant in order to evaluate applicability of AI to the autonomous operation and to have a prospect for the realization of the system. The prototype system executes diagnosis, state evaluation, operation and control for the main plant subsystems. (author)

214

Synthesis and SAR of new pyrazolo[4,3-h]quinazoline-3-carboxamide derivatives as potent and selective MPS1 kinase inhibitors.  

Science.gov (United States)

The synthesis and SAR of a series of novel pyrazolo-quinazolines as potent and selective MPS1 inhibitors are reported. We describe the optimization of the initial hit, identified by screening the internal library collection, into an orally available, potent and selective MPS1 inhibitor. PMID:21723120

Caldarelli, Marina; Angiolini, Mauro; Disingrini, Teresa; Donati, Daniele; Guanci, Marco; Nuvoloni, Stefano; Posteri, Helena; Quartieri, Francesca; Silvagni, Marco; Colombo, Riccardo

2011-08-01

215

Structure-based design of orally bioavailable 1H-pyrrolo[3,2-c]pyridine inhibitors of mitotic kinase monopolar spindle 1 (MPS1).  

Science.gov (United States)

The protein kinase MPS1 is a crucial component of the spindle assembly checkpoint signal and is aberrantly overexpressed in many human cancers. MPS1 is one of the top 25 genes overexpressed in tumors with chromosomal instability and aneuploidy. PTEN-deficient breast tumor cells are particularly dependent upon MPS1 for their survival, making it a target of significant interest in oncology. We report the discovery and optimization of potent and selective MPS1 inhibitors based on the 1H-pyrrolo[3,2-c]pyridine scaffold, guided by structure-based design and cellular characterization of MPS1 inhibition, leading to 65 (CCT251455). This potent and selective chemical tool stabilizes an inactive conformation of MPS1 with the activation loop ordered in a manner incompatible with ATP and substrate-peptide binding; it displays a favorable oral pharmacokinetic profile, shows dose-dependent inhibition of MPS1 in an HCT116 human tumor xenograft model, and is an attractive tool compound to elucidate further the therapeutic potential of MPS1 inhibition. PMID:24256217

Naud, Sébastien; Westwood, Isaac M; Faisal, Amir; Sheldrake, Peter; Bavetsias, Vassilios; Atrash, Butrus; Cheung, Kwai-Ming J; Liu, Manjuan; Hayes, Angela; Schmitt, Jessica; Wood, Amy; Choi, Vanessa; Boxall, Kathy; Mak, Grace; Gurden, Mark; Valenti, Melanie; de Haven Brandon, Alexis; Henley, Alan; Baker, Ross; McAndrew, Craig; Matijssen, Berry; Burke, Rosemary; Hoelder, Swen; Eccles, Suzanne A; Raynaud, Florence I; Linardopoulos, Spiros; van Montfort, Rob L M; Blagg, Julian

2013-12-27

216

Security alarm communication and display systems development  

International Nuclear Information System (INIS)

Sandia National Laboratories (SNL) has, as lead Department of Energy (DOE) physical security laboratory, developed a variety of alarm communication and display systems for DOE and Department of Defense (DOD) facilities. This paper briefly describes some of the systems developed and concludes with a discussion of technology relevant to those currently designing, developing, implementing, or procuring such a system. Development activities and the rapid evolution of computers over the last decade have resulted in a broad variety of capabilities to support most security system communication and display needs. The major task in selecting a system is becoming familiar with these capabilities and finding the best match to a specific need

217

Development Of A Vision Guided Robot System  

Science.gov (United States)

This paper presents the development of an intelligent vision guided system through the integration of a vision system into a robot. Systems like the one described in this paper are able to work alone. They can be used in many automated assembly operations. Such systems can do repetitive tasks more efficiently and accurately than human operators because of the immunity of machines to human factors such as boredom, fatigue, and stress. In order to better understand the capabilities of such systems, this paper will highlight what can be accomplished by such systems by detailing the development of such a system. This system is already built and functional.

Torfeh-Isfahani, Mohammad; Yeung, Kim F.

1987-10-01

218

Phased array based ultrasound scanning system development  

Science.gov (United States)

Multichannel ultrasound scanning system based on phased arrays development is presented in this paper. Substantiation of system parameters is presented. The description of block diagram and hardware development is presented. The combination of the self-developed receiving and a transmitting units and commercially available FPGA unit and Personal Computer can solve our scientific goals, while providing a relatively low device cost.

Sagdiev, R. K.; Denisov, E. S.; Evdokimov, Yu K.; Fazlyyyakhmatov, M. G.; Kashapov, N. F.

2014-12-01

219

X2000 power system electronics development  

Science.gov (United States)

The X2000 Power System Electronics (PSE) is a Jet Propulsion Laboratory (JPL) task to develop a new generation of power system building blocks for potential use on future deep space missions. The effort includes the development of electronic components and modules that can be used as building blocks in the design of generic spacecraft power systems.

Carr, Greg; Deligiannis, Frank; Franco, Lauro; Jones, Loren; Lam, Barbara; Nelson, Ron; Pantaleon, Jose; Ruiz, Ian; Treichler, John; Wester, Gene; Sauers, Jim; Giampoli, Paul; Haskell, Russ; Mulvey, Jim; Repp, John

2005-01-01

220

Development of Baby-EBM Interface System  

International Nuclear Information System (INIS)

This paper explains the works being done to develop an interface system for Baby-Electron Beam Machine (EBM). The function of the system is for the safety, controlling and monitoring the Baby-EBM. The integration for the system is using data acquisition (DAQ) hardware and LabVIEW to develop the software. (author)

221

Computer graphics for robot system development  

International Nuclear Information System (INIS)

The role of computer graphics in the development of a robot system is described. Emphasis is placed on the use of graphics simulation and robotic system animation for software development, system monitoring, operator assistance during manual error recovery, and operator training

222

The safety of dipyridamole myocardial perfusion scintigraphy (MPS) in patients with end-stage chronic airways limitations (CAL)  

International Nuclear Information System (INIS)

Full text: Dipyridamole MPS is a well-established investigative technique in the diagnosis and pre-operative risk stratification of patients with possible coronary artery disease. However, there remains a concern of its use in patients with end-stage chronic airways limitations (CAL). Lung volume reduction surgery (LVRS) is a recent therapeutic option for such patients. The options for non-invasive pre-operative cardiac assessment in such patients are limited. This study reviewed the safety of dipyridamole use in such a clinical setting. 20 patients (10M, 10F, mean age 64.8 yrs) were evaluated. None had any history of ischaemic heart disease. Dipyridamole was administered intravenously at a dose of 0.05 mg/kg. Six patients remained asymptomatic throughout the procedure, while none experienced any chest pain. Two patients experienced moderate dyspnoea, which was rapidly relieved with aminophylline (100mg IV) during the recovery phase of the study. Two others developed mild dyspnoea; one settled spontaneously, while the other responded promptly to aminophylline. Aminophylline was administered to nine other patients to reverse minor symptoms (headache, flushing sensation). One other patient developed marked hypotension (SBP fell >20mmHg) and bradycardia, but no ECG changes for myocardial ischaemia. He responded well to aminophylline. His myocardial perfusion scan demonstrated extensive reversible myocardial ischaemia. Although the population size was small, dipyridamole e population size was small, dipyridamole appears safe to use in patients with end-stage CAL. Copyright (2000) The Australian and New Zealand Society of Nuclear Medicine Inc

223

Dynamic calibration technique for the micro-pillar shear-stress sensor MPS3  

International Nuclear Information System (INIS)

Based on magnetic excitation a dynamic calibration technique for the micro-pillar shear-stress sensor MPS3, which allows one to determine the local wall-shear stress in turbulent flows by optically measuring the velocity gradient within the viscous sublayer of turbulent flows, is described. The proposed dynamic calibration technique allows one to assess the micro-pillar dynamic response for different flow media up to approximately 10 kHz. The results convincingly agree with the findings of a second-order analytical approximation based on experimentally determined damped eigenfrequencies and damping coefficients. Measurements for different sensor geometries and in various fluids show the sensor to possess transfer functions ranging from a flat low-pass filtered response to strong resonant behavior

224

Social networks, politics and Commitment 2.0: Spanish MPs on Facebook  

Directory of Open Access Journals (Sweden)

Full Text Available In a technologically and sociologically advanced society, the organizations that do not use the new media and the cyber communication techniques are probably doomed to failure. In this virtual sphere the social networks constitute a suitable resource and channel for the implementation of political marketing 2.0, as it provides a scenario where the interaction with users is possible. From this perspective, we verified their presence of the 350 members of the Spanish Congress on Facebook, the country’s most popular social network, in order to establish the predominant typologies, updating frequency, contents, resources, and the types of information posted in this spaces.This article also examines the interactivity of MPs in what we have termed Commitment 2.0: political communication in personal contexts such as social networks requires going from the participatory attitude to the participatory action; that is, to accept the interaction 2.0 as the correct behaviour on the network.

José Sixto, B.A.

2011-01-01

225

MPS Eesti juht Pasi Harttunen : heaks spetsialistiks saab vaid alumiselt astmelt alustades / Pasi Harttunen ; interv. Tiina Saar  

Index Scriptorium Estoniae

Personalifirma MPS Eesti juht vastab küsimustele, mis puudutavad Eesti tööandjaid, kellel pole raskusi spetsialistide leidmisel, hea või halva tööandja mainega ettevõtteid, võtmetöötajate suurt liikuvust, spetsialistide motiveerimist ja nende usaldamist, kõige enam spetsialistide puuduse käes vaevlevaid valdkondi ning haridussüsteemi taset spetsialistide koolitamisel. Vt. samas: Kersti Valter. Spetsialistide palgaootused rahunenud; Karin Press. Napib kriisidega toime tulnud spetsialiste

Harttunen, Pasi, 1971-

2008-01-01

226

The Simulator of the Timing and Magnitude of Pollen Season (STaMPS model: a pollen production model for regional emission and transport modeling  

Directory of Open Access Journals (Sweden)

Full Text Available A pollen model that simulates the timing and production of wind-dispersed allergenic pollen by terrestrial, temperate vegetation has been developed to quantify how pollen occurrence may be affected by climate change and to investigate how pollen can interact with anthropogenic pollutants to affect human health. The Simulator of the Timing and Magnitude of Pollen Season (STaMPS model is driven by local meteorological conditions and is designed to be sensitive to climate shifts, as well as flexible with respect to the vegetation species and plant functional types (trees, grasses, etc. represented and the climate zones simulated. The initial focus for the model is the simulation of the pollen emission potential of important allergenic tree and grass species that typically flower between March–June in Southern California (S. CA, which is characterized by moderate Mediterranean and oceanic climate zones as well as regions of arid desert and arid steppe. Vegetation cover and species composition data are obtained from numerous datasets and a database of allergenic vegetation species, their pollen production potential and relative allergenicities has been developed. For the selected allergenic species and spring-early summer simulation period, temperature is the main driver controlling the timing of pollen release, while precipitation (and temperature, for some species controls the magnitude of pollen produced. The model provides species-specific pollen potential maps for each day of the simulation period; these are then used by a pollen transport model to simulate ambient pollen concentrations as described in a companion paper (Zhang et al., 2013a, which also presents model evaluation results for the S. CA model domain. The STaMPS model was also used to quantify the possible impact of climate change on pollen season under the IPCC SRES A1B scenario as simulated by the ECHAM5 global climate model. Current (1995–2004 and future (2045–2054 meteorological conditions downscaled using the Weather Research and Forecasting (WRF model were used to drive STaMPS and generate estimates of the relative magnitude and timing of pollen season for important allergenic tree and grass species that bloom from March through June in a larger domain that covers all of CA and Nevada. Differences in the simulated timing and magnitude of pollen season for the selected allergenic species under current and future climate scenarios are presented. The results suggest that across all of the simulated species, pollen season starts an average of 5–6 days earlier under predicted future climatic conditions with an associated average annual domain-wide temperature increase of about 1°C compared to simulated current conditions. Differences in the amount of pollen produced under the two scenarios vary by species and are affected by the selected simulation period (1 March–30 June. Uncertainties associated with the STaMPS model and future model development plans are also discussed.

T. R. Duhl

2013-04-01

227

Development of geophysical data management system  

Energy Technology Data Exchange (ETDEWEB)

(1) Development of a complete geophysical database system under C/S environment for data management. (2) Development of database system for the general user, who has not special knowledge of database, under the Internet environment. (3) Operation of the Web service for the general user. (4) Development of the stand-alone database system for a small-scale research group such as college and engineering consultant firms. (author). 15 refs.

Lee, Tai-Sup; Lee, Sang-Kyu; Gu, Sung-Bon [Korea Institute of Geology Mining and Materials, Taejon (KR)] (and others)

1999-12-01

228

Selective inhibition of pancreatic ductal adenocarcinoma cell growth by the mitotic MPS1 kinase inhibitor NMS-P715.  

Science.gov (United States)

Most solid tumors, including pancreatic ductal adenocarcinoma (PDAC), exhibit structural and numerical chromosome instability (CIN). Although often implicated as a driver of tumor progression and drug resistance, CIN also reduces cell fitness and poses a vulnerability that can be exploited therapeutically. The spindle assembly checkpoint (SAC) ensures correct chromosome-microtubule attachment, thereby minimizing chromosome segregation errors. Many tumors exhibit upregulation of SAC components such as MPS1, which may help contain CIN within survivable limits. Prior studies showed that MPS1 inhibition with the small molecule NMS-P715 limits tumor growth in xenograft models. In cancer cell lines, NMS-P715 causes cell death associated with impaired SAC function and increased chromosome missegregation. Although normal cells appeared more resistant, effects on stem cells, which are the dose-limiting toxicity of most chemotherapeutics, were not examined. Elevated expression of 70 genes (CIN70), including MPS1, provides a surrogate measure of CIN and predicts poor patient survival in multiple tumor types. Our new findings show that the degree of CIN70 upregulation varies considerably among PDAC tumors, with higher CIN70 gene expression predictive of poor outcome. We identified a 25 gene subset (PDAC CIN25) whose overexpression was most strongly correlated with poor survival and included MPS1. In vitro, growth of human and murine PDAC cells is inhibited by NMS-P715 treatment, whereas adipose-derived human mesenchymal stem cells are relatively resistant and maintain chromosome stability upon exposure to NMS-P715. These studies suggest that NMS-P715 could have a favorable therapeutic index and warrant further investigation of MPS1 inhibition as a new PDAC treatment strategy. PMID:24282275

Slee, Roger B; Grimes, Brenda R; Bansal, Ruchi; Gore, Jesse; Blackburn, Corinne; Brown, Lyndsey; Gasaway, Rachel; Jeong, Jaesik; Victorino, Jose; March, Keith L; Colombo, Riccardo; Herbert, Brittney-Shea; Korc, Murray

2014-02-01

229

Development of Calibration System for Contact Transducer  

International Nuclear Information System (INIS)

In this paper, the calibration system for contact transducer has been developed to improve the reliability of the inspection result of ultrasonic testing on rotors. This system consists of signal processing parts: (oscilloscope, spectrum analyzer, pulser/receiver), standard block, and user interface program. Signal processing for the calibration system was performed quickly with high accuracy. The developed system has been applied to a practical calibration of probe using the non-destructive testing on rotors, and demonstrated high sensitivity and precision

230

Development of the MONJU data bank system  

International Nuclear Information System (INIS)

A centralized plant dynamics data base system is under development for the prototype LMFBR MONJU. The data base system incorporates all related plant dynamics data, together with the basis for the data. A special feature of the system is the ability to manage and process a variety of data types, such as numerical data, tabular data, algebraic data, as well as text and graphical data. The system software, developed using FAIRS-I, currently includes such functions as retrieval, display and compile. (author)

231

Needs and Possibility of Involving Nuclear Power Plant in the Macedonian Power System  

International Nuclear Information System (INIS)

The Macedonian Power System (MPS) used to be a part of the former Yugoslav Power System, and it was connected to the European system by 400 kV transmission lines. At the present time, the MPS works isolated from the UCPTE, only connected to the Yugoslav and Greek power systems. The connections with the Bulgarian and Albanian power systems are on a lower voltage level. The reliability and stability of the MPS needs to be improved. Macedonia is located in the central area of the Balkan, where the transmission systems from other Balkan countries are crossing. in the near future, the Macedonian Power System needs to be linked to the European system. To prepare for the energy demand at the beginning of the 21-st century, when the local coal reserves get exhausted, Macedonia needs to start with activities for substitution of the existing coal-fired thermal power plants with nuclear plants. This paper discusses the activities for global development solutions in the area of power generation. (author)

232

Japan Elaprase Treatment (JET) study: idursulfase enzyme replacement therapy in adult patients with attenuated Hunter syndrome (Mucopolysaccharidosis II, MPS II).  

Science.gov (United States)

This open-label clinical study enrolled 10 adults with attenuated Mucopolysaccharidosis II and advanced disease under the direction of the Japan Society for Research on Mucopolysaccharidosis Disorders prior to regulatory approval of idursulfase in Japan. Ten male patients, ages 21-53 years, received weekly intravenous infusions of 0.5 mg/kg idursulfase for 12 months. Significant reductions in lysosomal storage and several clinical improvements were observed during the study (mean changes below). Urinary glycosaminoglycan excretion decreased rapidly within the first three months of treatment and normalized in all patients by study completion (-79.9%). Liver and spleen volumes also showed rapid reductions that were maintained in all patients through study completion (-33.2% and -31.0%, respectively). Improvements were noted in the 6-Minute Walk Test (54.5 m), percent predicted forced vital capacity (3.8 percentage points), left ventricular mass index (-12.4%) and several joint range of motions (8.1-19.0 degrees). Ejection fraction and cardiac valve disease were stable. The sleep study oxygen desaturation index increased by 3.9 events/h, but was stable in 89% (8/9) of patients. Idursulfase was generally well-tolerated. Infusion-related reactions occurred in 50% of patients and were mostly mild with transient skin reactions that did not require medical intervention. Two infusion-related reactions were assessed as serious (urticaria and vasovagal syncope). One patient died of causes unrelated to idursulfase. Anti-idursulfase antibodies developed in 60% (6/10) of patients. In summary, idursulfase treatment appears to be safe and effective in adult Japanese patients with attenuated MPS II. These results are comparable to those of prior studies that enrolled predominantly pediatric, Caucasian, and less ill patients. No new safety risks were identified. PMID:19773189

Okuyama, Torayuki; Tanaka, Akemi; Suzuki, Yasuyuki; Ida, Hiroyuki; Tanaka, Toju; Cox, Gerald F; Eto, Yoshikatsu; Orii, Tadao

2010-01-01

233

Developing TRUPACT system impact resistance  

International Nuclear Information System (INIS)

The Transportation Technology Center at Sandia National Laboratories has taken the lead in the development of the TRansUranic PACkage Transporter I (TRUPACT-I) for transporting contact-handled transuranic waste. TRUPACT-I is a Type B package designed for transport by truck and rail. One of the regulatory requirements of a Type B package is that it survive a drop onto a 15.2-cm-dia punch. This paper discusses the development of the puncture resistant panels used in TRUPACT-I. Concepts tested ranged from monolithic steel plates to laminated Kevlar fabric bonded to a steel backing plate. The TRUPACT-I wall design incorporated the laminated Kevlar and stainless steel puncture panel

234

Canadian accelerator breeder system development  

International Nuclear Information System (INIS)

A shortage of fissile material at a reasonable price is expected to occur in the early part of the twenty-first century. Converting fertile material to fissile material by electronuclar methods is an option that can extend th world's resources of fissionable material, supplying fuel for nuclear power stations. This paper presents the rationale for electronuclear breeders and describes the Canadian development program for an accelerator breeder facility that could produce 1 Mg of fissile material per year

235

Information Systems Development as a Research Method  

Directory of Open Access Journals (Sweden)

Full Text Available This paper takes the stance that some cases of information systems development can be considered knowledge creating activities, and, in those cases, information systems development can be a legitimate research method. In these cases not only is knowledge created about the development process itself but also a deeper understanding emerges about the organisational problem that the system is designed to solve. The paper begins with a brief overview of research in the design sciences and a comparison of research methods that are concerned with the design, and use, of information systems. This is followed by an assessment of the way systems development as a research method deals with the scientific research processes of data collection, analysis, synthesis and display. A case study, where the systems development research method was use, is described to illustrate the method and give the reader a better understanding of the approach.

Helen Hasan

2003-11-01

236

Optical strain measurement system development  

International Nuclear Information System (INIS)

A laser speckle, differential strain measurement system has been built and tested for future applications in hostile environments. One-dimensional electronic correlation of speckle pattern movement allows a quasi-real time measure of strain. The system has been used successfully to measure uniaxial strain reaching into plastic deformation of a test specimen, at temperatures ranging to 450 C. A resolution of 126 microstrain is given by the photodiode array sensor pitch and the specimen to sensor separation. The strain measurement error is estimated to be +/-18 microstrain +/-3 percent of the strain reading. The upper temperature limit of the gauge is determined by air density perturbations causing decorrelation of the reference and shifted speckle patterns, and may be improved by limiting convective flow in the immediate vicinity of the test specimen

237

Eurofix System and its Developments  

Science.gov (United States)

This paper, and the following six papers, were presented during the NAV 98 Conference held at Church House, Westminster, London on 9th and 10th December 1998. A full listing of the Conference, and how to obtain a copy of the proceedings, is shown on Page 300.The existing Loran-C and Chayka infrastructure can, with some minor changes, become a very powerful augmentation system for GNSS (GPS, GLONASS and the future Galileo). Delft University initially proposed the Eurofix concept in 1989. Although the necessary modification to the LF navigation systems are minimal, the GNSS user may get significant benefits from the Eurofix signals in terms of accuracy, integrity and availability. The reason is the high signal structure, signal propagation, and the operations dissimilarity of both systems. The broadcast correction and integrity data improves GNSS accuracy down to the metre level. In this way, the measured Loran-C and Chayka ranges are continuously updated. Thus, in the case of GNSS signal interruptions, highly calibrated Loran-C/Chayka may take over the navigation function. Tests carried out in Europe at the Loran-C station at Sylt (Germany) drew large international attention, leading to further tests in the USA by the US Coast Guard in 1998. Recently, a Dutch-Russian consortium implemented Eurofix on the Chayka transmitter at Bryansk (Russia) which is now successfully broadcasting DGPS as well as DGLONASS correction data. This paper highlights some on-air Eurofix DGPS performance experiments carried out in Europe and the USA. With all the European Loran-C and Chayka transmitters modified, Eurofix can be used all over the European continent. As multiple stations can normally be received simultaneously, the user may locally apply networked DGNSS, which may reduce spatial decorrelation effects significantly. Post-processed results of this Regional Area Augmentation System are presented.

Offermans, G. W. A.; Helwig, A. W. S.; van Willigen, D.

238

Increased levels of circulating microparticles in primary Sjögren's syndrome, systemic lupus erythematosus and rheumatoid arthritis and relation with disease activity  

OpenAIRE

INTRODUCTION: Cell stimulation leads to the shedding of phosphatidylserine (PS)-rich microparticles (MPs). Because autoimmune diseases (AIDs) are characterized by cell activation, we investigated level of circulating MPs as a possible biomarker in primary Sjögren's syndrome (pSS), systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). METHODS: We measured plasma levels of total, platelet and leukocyte MPs by prothrombinase capture assay and flow cytometry in 43 patients with pSS, ...

Sellam, Je?re?mie; Proulle, Vale?rie; Ju?ngel, Astrid; Ittah, Marc; Miceli Richard, Corinne; Gottenberg, Jacques-eric; Toti, Florence; Benessiano, Joelle; Gay, Steffen; Freyssinet, Jean-marie; Mariette, Xavier

2009-01-01

239

An Educational System Development Game  

OpenAIRE

Educational computer games have been around for a long time. However, the work that is being done on educational computer games is mainly focused on an elementary school level. We feel that it is high time that educational computer games took the step into universities. To test the potential of using such games at a university level, we decided to develop our own game. In order to find out more about the important aspects of educational game design, we explored the research done within the fi...

Stikbakke, Jørgen; Molnes, Eirik

2008-01-01

240

A TPR domain-containing N-terminal module of MPS1 is required for its kinetochore localization by Aurora B.  

Science.gov (United States)

The mitotic checkpoint ensures correct chromosome segregation by delaying cell cycle progression until all kinetochores have attached to the mitotic spindle. In this paper, we show that the mitotic checkpoint kinase MPS1 contains an N-terminal localization module, organized in an N-terminal extension (NTE) and a tetratricopeptide repeat (TPR) domain, for which we have determined the crystal structure. Although the module was necessary for kinetochore localization of MPS1 and essential for the mitotic checkpoint, the predominant kinetochore binding activity resided within the NTE. MPS1 localization further required HEC1 and Aurora B activity. We show that MPS1 localization to kinetochores depended on the calponin homology domain of HEC1 but not on Aurora B-dependent phosphorylation of the HEC1 tail. Rather, the TPR domain was the critical mediator of Aurora B control over MPS1 localization, as its deletion rendered MPS1 localization insensitive to Aurora B inhibition. These data are consistent with a model in which Aurora B activity relieves a TPR-dependent inhibitory constraint on MPS1 localization. PMID:23569217

Nijenhuis, Wilco; von Castelmur, Eleonore; Littler, Dene; De Marco, Valeria; Tromer, Eelco; Vleugel, Mathijs; van Osch, Maria H J; Snel, Berend; Perrakis, Anastassis; Kops, Geert J P L

2013-04-15

241

Phosphorylation at threonine 288 by cell cycle checkpoint kinase 2 (CHK2) controls human monopolar spindle 1 (Mps1) kinetochore localization.  

Science.gov (United States)

Human Mps1 (hMps1) is a mitotic checkpoint kinase responsible for sensing the unattached and tensionless kinetochore. Despite its importance in safeguarding proper chromosome segregation, how hMps1 is recruited to the kinetochore remains incompletely understood. Here, we demonstrate that phosphorylation at Thr-288 by the cell cycle checkpoint kinase CHK2 is involved in this process. We discovered that the phosphorylation-deficient T288A mutant has an impaired ability to localize to the kinetochore and cannot reestablish the mitotic checkpoint in hMps1-depleted cells. In support, we found that nocodazole induced hMps1 phosphorylation at the previously identified CHK2 site Thr-288 and that this could be detected at the kinetochore in a CHK2-dependent manner. Mechanistically, phosphorylation at Thr-288 promoted the interaction with the KMN (KNL1-Mis12-Ndc80 network) protein HEC1. Forced kinetochore localization corrected the defects associated with the T288A mutant. Our results provide evidence of a newly identified hMps1 phosphorylation site that is involved in the mitotic checkpoint and that CHK2 contributes to chromosomal stability through hMps1. PMID:24764296

Yeh, Chun-Wei; Yu, Zheng-Cheng; Chen, Peng-Hsu; Cheng, Yu-Che; Shieh, Sheau-Yann

2014-05-30

242

The Systems Development Dilemma: Whether to Adopt Formalised Systems Development Methodologies or Not?  

OpenAIRE

Systems development issues occupy a position of central imponance in the information systems field and, indeed.. much has been prescribed in the quest for successful systems development. However. given the well· documented Msoftwarc: crisis", success is far from guaranteed for many systems development projects. Many researchers see the solution to the software crisis in terms of increased control and the morc widespread adoption of rigorous and formalised system development metho...

Fitzgerald, Brian

1994-01-01

243

Development of Architectures for Internet Telerobotics Systems  

OpenAIRE

This paper presents our experience in developing and implementing Internet telerobotics system. Internet telerobotics system refers to a robot system controlled and monitored remotely through the Internet. A robot manipulator with five degrees of freedom, called Mentor, is employed. Client-server architecture is chosen as a platform for our Internet telerobotics system. Three generations of telerobotics systems have evolved in this research. The first generation was based on...

Bambang, Riyanto

2008-01-01

244

Development of Environmental Radiation Monitoring System  

Energy Technology Data Exchange (ETDEWEB)

This paper is a final report of the research project which is development of environmental radiation monitoring system(ERMS) for nuclear power plant(NPP) area. It contains -Analysis and design for the developments of ERMS -Study on radiation monitoring systems and Environmental radiation detection methods -H/W development : Counter and ion interface, Dose conversion unit, Single channel analyzer, Microprocessor controller -S/W development : Communication, Control, and Operation program - And the performance analysis and test results of the system for Kori NPP operation. (author). 48 refs., 19 figs., 22 tabs.

Choi, S.S.; Oh, G.H.; Chang, T.W.; Jang, T.I. [Korea Electric Power Research Institute, Taejeon (Korea, Republic of); Lee, K.H.; Ha, D.K.; Jung, Y.J.; Ro, W.Y.; Shin, D.Y.; Jang, S.B.; Shin, H.M.; Cho, H.S. [Electrical Engineering and Science Research Institute, Seoul (Korea, Republic of)

1997-12-31

245

Testing Infrastructure for Operating System Kernel Development  

DEFF Research Database (Denmark)

Testing is an important part of system development, and to test effectively we require knowledge of the internal state of the system under test. Testing an operating system kernel is a challenge as it is the operating system that typically provides access to this internal state information. Multi-core kernels pose an even greater challenge due to concurrency and their shared kernel state. In this paper, we present a testing framework that addresses these challenges by running the operating system in a virtual machine, and using virtual machine introspection to both communicate with the kernel and obtain information about the system. We have also developed an in-kernel testing API that we can use to develop a suite of unit tests in the kernel. We are using our framework for for the development of our own multi-core research kernel.

Walter, Maxwell; Karlsson, Sven

2014-01-01

246

Doing learning : engineers in systems development  

DEFF Research Database (Denmark)

Purpose: To investigate how learning occurs in a systems development project, using a company developing wind turbine control systems in collaboration with customers as case. Design/methodology/approach: Dewey’s approach to learning is used, emphasising reciprocity between the individual’s experience and the sociotechnical practice. The framework involves the concepts of sociotechnical practice, anchoring of indeterminate situation, and strip of doings towards determinate situation. An ethnographic study was made of four cases of systems development. Findings: An extreme case reveals initiated learning processes and that the interchanges between materiality and systems developers block the learning processes due to a customer with imprecise demands and unclear system specifications. In the four cases discussed, learning does occur however. Research limitations/implications: A qualitative study focusing on individual systems developers gives limited insight into whether the learning processes found would occur in other systems development processes. Practical implications: Managers should ensure that constitutive means, such as specifications, are available, and that they are sufficiently obdurate. Too ductile means, such as customers with unclear demands, can block learning processes. Systems developers with different experience also enable learning processes. Converging anchoring of the indeterminate situation being handled enables collective learning. Focusing on this, systems development companies can safeguard their learning and product embedded knowledge when engaging in interorganisational collaboration handling the risk of giving knowledge away. Originality/value: The specific contribution involves Dewey’s approach to learning with focus on micro-processes of the individual systems developer’s learning, adding the possibility for collective learning.

Mathiasen, John Bang; Koch, Christian

247

Management Planning for Library Systems Development  

OpenAIRE

This paper deals with the application to library systems development programs of planning techniques which long ago proved their usefulness in business, military, and aerospace developments. The significant features of PERT (Program Evaluation and Review Technique), WBS (Work Breakdown Structure), planning diagrams, statements of work, cost/time estimates, schedules, manpower loading, and cost phasing are related through an example to the management requirements of a mafor systems development...

Bellomy, Fred L.

2013-01-01

248

System model development for nuclear thermal propulsion  

Science.gov (United States)

The strategy and progress of an interagency NASA/DOE/DOD team for nuclear thermal propulsion (NTP) system modeling are presented. The main goal of the interagency team is to develop several levels of computer programs for predicting the performance of various NTP systems. These programs are being developed to support the evaluation of conceptual designs and to provide a diagnostic tool for understanding system tests.

Walton, James T.; Hannan, Nelson A.; Perkins, Ken R.; Buksa, John J.; Worley, Brian A.; Dobranich, Dean

1992-01-01

249

Information system in development of learning organization  

OpenAIRE

The thesis paper analyzes the role of information systems developing the learning organization concept in the higher educational institutions‘ environment. On a basis of scientific literature analysis, a detailed research on a learning organization and analysis of concepts of information system are carried out, close communication between development of the concept of the learning organization and uses of information systems is emphasized. In the paper the information infrastructure of Klai...

Pankova, Jelena

2006-01-01

250

The Online Faculty Development and Assessment System  

OpenAIRE

This article evaluates the role of the Online Faculty Development and Assessment System (OFDAS), created at universities in the Canary Islands, Spain, in staff development. The evaluation indicates that the system helped staff in learning to teach curriculum and teaching capacities. The tasks, online resources and opportunities for discussions provided within the learning environment created for the system helped shape their attitudes towards learning curriculum and teaching capacities and en...

Villar, Luis M.; Alegre, Olga M.

2007-01-01

251

Tribes of Users and System Developers  

Directory of Open Access Journals (Sweden)

Full Text Available Effective communication is essential for information systems development crossing functional, organisational and national boundaries. As organisations attempt to overcome cultural barriers to communication across the world, communication with colleagues across the corridor remains problematic; cultural barriers between departments remain unchallenged. This paper introduces the concepts of 'culture' and 'tribe' into the discussion of the relationship between business users and information systems developers. Previous research has focused on identifying specific barriers to user-systems developer communication and on ways of eliminating these barriers. In contrast, this paper suggests that much can be learnt through the recognition of cultural differences inherent to the differing roles of user and systems developer. Maintenance of cultural identity is essential to the individual if he/she is to function effectively as a member of his/her tribe, whether it is the 'tribe' of developers or the 'tribe' of users. Communication problems within the systems development process may be addressed by a mutual understanding of cultural differences between the 'tribes' of users and systems developers. This degree of understanding cannot be achieved by attempting to change, persuade or convert the other tribe. The problems of user-systems developer communication need to be addressed through effective communication which acknowledges the differing cultures.

Sharon Dingley

2000-05-01

252

Safeguards -Safeguards system development support-  

International Nuclear Information System (INIS)

This project mainly focused to technically support national safeguards inspection which is scheduled in the beginning of 1997. It includes non-destructive assay of nuclear fuels, analysis on inspection and environmental samples, remote monitoring of nuclear activities and its analysis, survey on remote sensing of satellite for safeguards application. Non-destructive assay of nuclear fuels dealt with development on verification of spent fuels with emphasis to fabrication of inspection tools with surveillance and gamma measurement on CANDU spent fuels. For sample analysis, study was carried out on process inspection sample analysis method. In addition to this, ultra low background laboratory was set up to execute environmental and swipe samples and sample treatment techniques including water, soil, plant, et al. were researched. Tritiums which were sampled around power plants were analysed. With cooperation of Satellite Technology Research Center of KAIST, use of civilian satellite imagery was surveyed. To train facility operators for safeguards, various technology on non-destructive assay was lectured to personnel of Korea Electric Power Corporation. And to enhance out capabilities, non-destructive assay training was done at Los Alamos National Lab. of U.S. through the agreement of MOST and DOE agreement, and information on DA technology was exchanged at Nuclear Material Control Center of Japan. (author). 22 tabs., 52 figs., 53 refs

253

Inactivation of the mitogen-activated protein kinase Mps1 from the rice blast fungus prevents penetration of host cells but allows activation of plant defense responses  

OpenAIRE

The rice blast fungus, Magnaporthe grisea, generates enormous turgor pressure within a specialized cell called the appressorium to breach the surface of host plant cells. Here, we show that a mitogen-activated protein kinase, Mps1, is essential for appressorium penetration. Mps1 is 85% similar to yeast Slt2 mitogen-activated protein kinase and can rescue the thermosensitive growth of slt2 null mutants. The mps1–1? mutants of M. grisea have some phenotypes in common with slt2 mutants of yea...

Xu, Jin-rong; Staiger, Christopher J.; Hamer, John E.

1998-01-01

254

Development of energy harvester system for avionics  

Science.gov (United States)

This paper deals with an energy harvesting system for avionics; it is an energy source for a unit which is used for wireless monitoring or autonomous control of a small aircraft engine. This paper is focused on development process of energy harvesting system from mechanical vibrations in the engine area. The used energy harvesting system consists of an electro-magnetic energy harvester, power management and energy storage element. The energy harvesting system with commercial power management circuits have to be tested and verified measured results are used for an optimal redesign of the electro-magnetic harvester. This developmental step is necessary for the development of the optimal vibration energy harvesting system.

Hadas, Z.; Vetiska, V.; Ancik, Z.; Ondrusek, C.; Singule, V.

2013-05-01

255

Multiple IMU system development, volume 1  

Science.gov (United States)

A redundant gimballed inertial system is described. System requirements and mechanization methods are defined and hardware and software development is described. Failure detection and isolation algorithms are presented and technology achievements described. Application of the system as a test tool for shuttle avionics concepts is outlined.

Landey, M.; Mckern, R.

1974-01-01

256

Development of the Digital Reactor Safety System  

International Nuclear Information System (INIS)

Objectives of Project - Development of Digital Safety Grade PLC and Licensing - Development of Safety System(RPS) and Licensing - Development of Safety System(ESF-CCS) and Licensing Content and Result of Project - POSAFE-Q PLC : Development of PLC platform for Shin-UCN unit 1 and 2 ·Development Scope : Processor module, Power module, 3 kinds of Communication module, Bus extension module(Master and Slave), 16 kinds of Input and Output module ·PLC application software development tool(pSET) - IDiPS RPS and IDiPS ESF-CCS : Development of PPS for Sin-UCN 1 and 2 ·Development Scope - 4-channels RPS with the KNICS inherent architecture - A part of 1-channels ESF-CCS with the KNICS inherent architecture - Licensing ·optical Report Submitted and Expected to finish the licensing process until Aug. 2008

257

SP-100 power system development status  

International Nuclear Information System (INIS)

The SP-100 ground engineering system development project objectives, approach and status are described. The SP-100 GES development project is phase II of a three-phase program funded and directed by three United States Federal Agencies (NASA, DOD and DOE) to develop space reactor power systems for space applications in the 10 to 1000 KWe power range. The first phase of the program lasted three years, and this was completed at the end of FY 1985. SP-100 Phase I analytically and experimentally reviewed all near-term space reactor power system candidates and selected one system that best met the project mission requirements for future civilian and military space applications. The SP-100 Phase II started in fiscal year 1986 to develop the Phase I selected space reactor power system to be technically ready for space applications in the mid-to late 1990s. (author)

258

System model development for nuclear thermal propulsion  

International Nuclear Information System (INIS)

A critical enabling technology in the evolutionary development of nuclear thermal propulsion (NTP) is the ability to predict the system performance under a variety of operating conditions. Since October 1991, US (DOE), (DOD) and NASA have initiated critical technology development efforts for NTP systems to be used on Space Exploration Initiative (SEI) missions to the Moon and Mars. This paper presents the strategy and progress of an interagency NASA/DOE/DOD team for NTP system modeling. It is the intent of the interagency team to develop several levels of computer programs to simulate various NTP systems. An interagency team was formed for this task to use the best capabilities available and to assure appropriate peer review. The vision and strategy of the interagency team for developing NTP system models will be discussed in this paper. A review of the progress on the Level 1 interagency model is also presented

259

SNAP reactor reflector control systems development  

International Nuclear Information System (INIS)

The Systems for Nuclear Auxiliary Power (SNAP) reactor reflector control systems have been reviewed for near-term use of the reflector control technology developed during the SNAP space reactor program. The launch and operating environment for which the SNAP reflector control systems were designed is discussed. System design and operation for each of the SNAP reactor control systems are discussed. Major component design and development work, as well as the reactor system and individual component testing are summarized. The reactor control system technology is directly applicable to SNAP-DYN, the latest uranium-zirconium hydride space reactor design. This control system technology is truly state of the art for use in future military and civilian space power programs

260

[Complement system in status asthmatics--analysis of anti-complementary effects induced by methylprendisolone].  

Science.gov (United States)

Complement system was investigated in 7 patients with status asthmatics treated with large doses of methylprednisolone (MPS). Complement hemolytic activities, complement protein profile, complement fragments and circulating immune complexes were measured before, 3 and 8 hours after and 14 days after MPS administration. MPS normalized C4 and C1INH activities 6 hours after administration. MPS also decreased ACH50 6 hours after administration and D activity 3 and 6 hours after, but these activities recovered to their previous normal range within 14 days. P and H were decreased at each measurement time, and C1s was transiently decreased 6 hours after MPS administration. Complement fragment iC3b was increased at each measurement time, but fragment Bb tended to be decreased 14 days after MPS administration. The increment of anaphylatoxin C3a recovered to normal 14 days after MPS administration. In vitro experiments, MPS inhibited D and C1s activation directly, and decreased the decay of B and C4. Inhibition of C1s might also increase C1INH activity clinically. These results clarified that the alternative complement pathway was activated, and suggested that the C1 bypass pathway might be also activated in status asthmatics. It was further considered that these anti-complementary effects induced by MPS, brought about an improvement in asthmatic symptoms. Studies to identify the complement activators continued, and circulating immune complexes may possibly be one of those agents activating complement cascade. PMID:1492790

Onodera, H; Takemura, S; Kasamatsu, Y; Nakanishi, S; Seto, N; Ichio, N; Nakahara, R; Doi, T; Okamoto, M; Yanagida, K

1992-11-01

261

Development of intelligent operation control system  

International Nuclear Information System (INIS)

Power Reactor and Nuclear Fuel Development Corp. participates in the developments of an intelligent operation control system (IOCS) and an intelligent maintenance control system (IMCS) for automatic operation and maintenance of nuclear power plant. The present situations and perspectives of these developments and researches were reviewed. In the period of 1991-1995, development of a prototype system for the assessment of the availability of IOCS ws tried and a plant diagnosis system based on a hierarchical function model and a control of plant operation according to a hierarchically operating strategy model were introduced. An object-oriented multi-agent system was applied to develop the IOCS consisting of subsystems in four levels and a man-machine interface able to display the operating conditions of those subsystems for operating managers was equipped to this system. The functions of each subsystem were evaluated by building block typed simulator. Aiming to construct some test systems we have a plan to materialize the processing algorithm and a system for each functional agent and also to establish a system to coordinate the respective agents. (M.N.)

262

Development and application of earth system models  

OpenAIRE

The global environment is a complex and dynamic system. Earth system modeling is needed to help understand changes in interacting subsystems, elucidate the influence of human activities, and explore possible future changes. Integrated assessment of environment and human development is arguably the most difficult and most important “systems” problem faced. To illustrate this approach, we present results from the integrated global system model (IGSM), which consists of coupled submodels add...

Prinn, Ronald G.

2012-01-01

263

Recent Developments on Chaos in Mechanical Systems  

OpenAIRE

Recent advancements in complexity of mechanical systems have led to the application of chaos theory. In this paper, some recent developments on chaos in mechanical systems are explored. The aim is to bring together researchers from various interests of mechanical systems, exposing them to chaos theory. This exposure gives researchers from the discipline of mechanical systems to find opportunity of cross disciplinary research, which may ultimately lead to novel solutions and understanding of m...

Mohammad Sajid

2013-01-01

264

Development of environment radiation database management system  

Energy Technology Data Exchange (ETDEWEB)

In this development, we constructed a database for efficient data processing and operating of radiation-environment related data. Se developed the source documents retrieval system and the current status printing system that supports a radiation environment dta collection, pre-processing and analysis. And, we designed and implemented the user interfaces and DB access routines based on WWW service policies on KINS Intranet. It is expected that the developed system, which organizes the information related to environmental radiation data systematically can be utilize for the accurate interpretation, analysis and evaluation.

Kang, Jong Gyu; Chung, Chang Hwa; Ryu, Chan Ho; Lee, Jin Yeong; Kim, Dong Hui; Lee, Hun Sun [Daeduk College, Taejon (Korea, Republic of)

1999-03-15

265

Gas tagging system development in Japan  

International Nuclear Information System (INIS)

The Gas tagging method has been considered to be most desirable for a failed fuel location system for the fast breeder reactor, regarding the component reduction in the reactor vessel and rapid location during reactor operation. The gas tagging system has been designed by referring to R and D results obtained in Japan and other countries. The designed system is comprised of tag gas filling pins, cover gas sampling system, tag gas recovery and enrichment system, tag gas analyzer and system control and data handling computers. The main specifications for this system have been decided as follows; 1) Main function is location of failed fuels in core and a part of blanket region, 2) Identification capability is each subassembly, 3) Time for identification is within a few days, 4) Continuous operation with automatic start at fuel failure, 5) Detection sensitivity must cover both gas leak and pin burst. In designing the gas tagging system, the following R and D items were selected; 1) System design study, 2) Tag gas capsule development, 3) Modeling the tag gas behavior in reactor primary cooling system, 4) Tag gas recovery and enrichment system, 5) Computer code development for tag gas isotope ratio change estimation. Details of the Japanese gas tagging system development appear in this paper. (author)

266

Development of an autonomous power system testbed  

International Nuclear Information System (INIS)

A power system testbed has been assembled to advance the development of large autonomous electrical power systems required for the space station, spacecraft, and aircraft. The power system for this effort was designed to simulate single- or dual-bus autonomous power systems, or autonomous systems that reconfigure from a single bus to a dual bus following a severe fault. The approach taken was to provide a flexible power system design with two computer systems for control and management. One computer operates as the control system and performs basic control functions, data and command processing, charge control, and provides status to the second computer. The second computer contains expert system software for mission planning, load management, fault identification and recovery, and sends load and configuration commands to the control system

267

Appendix E: Parallel Pascal development system  

Science.gov (United States)

The Parallel Pascal Development System enables Parallel Pascal programs to be developed and tested on a conventional computer. It consists of several system programs, including a Parallel Pascal to standard Pascal translator, and a library of Parallel Pascal subprograms. The library includes subprograms for using Parallel Pascal on a parallel system with a fixed degree of parallelism, such as the Massively Parallel Processor, to conveniently manipulate arrays which have dimensions than the hardware. Programs can be conveninetly tested with small sized arrays on the conventional computer before attempting to run on a parallel system.

1985-01-01

268

Automated Operations Development for Advanced Exploration Systems  

Science.gov (United States)

Automated space operations command and control software development and its implementation must be an integral part of the vehicle design effort. The software design must encompass autonomous fault detection, isolation, recovery capabilities and also provide "single button" intelligent functions for the crew. Development, operations and safety approval experience with the Timeliner system onboard the International Space Station (ISS), which provided autonomous monitoring with response and single command functionality of payload systems, can be built upon for future automated operations as the ISS Payload effort was the first and only autonomous command and control system to be in continuous execution (6 years), 24 hours a day, 7 days a week within a crewed spacecraft environment. Utilizing proven capabilities from the ISS Higher Active Logic (HAL) System, along with the execution component design from within the HAL 9000 Space Operating System, this design paper will detail the initial HAL System software architecture and interfaces as applied to NASA's Habitat Demonstration Unit (HDU) in support of the Advanced Exploration Systems, Autonomous Mission Operations project. The development and implementation of integrated simulators within this development effort will also be detailed and is the first step in verifying the HAL 9000 Integrated Test-Bed Component [2] designs effectiveness. This design paper will conclude with a summary of the current development status and future development goals as it pertains to automated command and control for the HDU.

Haddock, Angie T.; Stetson, Howard

2012-01-01

269

Common N-acetylgalactosamine-6-sulfate sulfatase (GALNS exon mutations in Brazilian patients with mucopolysaccharidosis IVA (MPS IVA  

Directory of Open Access Journals (Sweden)

Full Text Available Morquio A Syndrome (mucopolysaccharidosis IVA - MPS IVA, OMIM# 253000 is an autosomal recessive inborn error of metabolism caused by the deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS. We investigated five unrelated Brazilian MPS IVA families for mutations in exons 4, 5, 9 and 10 of the GALNS gene. Six out of the 10 mutant alleles were identified. Taken together with a previous study, which included six unrelated families, common mutations among Brazilian patients were p.N164T, p.G116S and p.G301C. Among one hundred control subjects three novel silent mutations were found (p.A107A; GCC -> GCT, p.Y108Y; TAC -> TAT, p.P357P; CCG -> CCA. Screening starting with exons 4, 5, 9, 10 and 11 may be a good strategy for genotyping of Brazilian patients since these exons include 73% of all mutations identified in the current and previous studies.

Tatiana Dieter

2007-01-01

270

Severe phenotype in MPS II patients associated with a large deletion including contiguous genes.  

Science.gov (United States)

Hunter disease or mucopolysaccharidosis type II (MPS II) is an X-linked recessive lysosomal disorder caused by the deficiency of iduronate-2-sulfatase, which is involved in the catabolism of the glycosaminoglycans (GAGs) heparan and dermatan sulphate. Our aim was to analyze three patients with severe Hunter syndrome that showed a total deletion of the iduronate-2-sulphatase (IDS) gene, after exon by exon PCR. DNA was used as a template for PCR synthesis of IDS, FRAXA, FRAXE, and DXS1113 specific amplicons. The DNA analysis for all three patients demonstrated a complete deletion of IDS, FRAXA, and FRAXE contiguous genes. We further performed SNP-array to delineate the deletion breakpoints and to characterize the deletion extension in the different patients. The results indicated a ?9.4 Mb deletion in Patient 1, a ?3.9 Mb deletion of the Xq27.3-Xq28 and a ?3.1 Mb duplication of the X q28 region in Patient 2 and a ?41.8 Kb deletion in Patient 3. SNP-array was shown to be important to map for deletion breakpoints. A comprehensive molecular analysis in patients with Hunter syndrome, especially in the ones presenting the severe form, is important to the understanding of the genetic determinants of the phenotype and for the genetic counseling to be provided to the families. PMID:22492741

Brusius-Facchin, Ana Carolina; De Souza, Carolina Fischinger Moura; Schwartz, Ida Vanessa D; Riegel, Mariluce; Melaragno, Maria Isabel; Correia, Patrícia; Moraes, Lúcia Marques; Llerena, Juan; Giugliani, Roberto; Leistner-Segal, Sandra

2012-05-01

271

Development of the stock exchange information system  

Directory of Open Access Journals (Sweden)

Full Text Available The stock exchange represents the key institution for the development of capital market of any country. Thus the information system of every stock exchange must satisfy very strict international standards. The development of these systems is particularly difficult in countries in transition, due to intense economic and legal changes, lack of technical and financial resources, lack of experience and knowledge in the area of the capital market business, etc. Therefore the special software project management methodology for their realization must be clearly defined. In the development process of the Belgrade Stock Exchange (BSE information system a new software project management methodology for its realization has been defined, the application of which is illustrated through a series of different development stages of the Belgrade Stock Exchange information system. In order to make all the problems more comprehensive, only the continuous trading method is described, being the most frequently used trading method in the world.

Miladinovi? Radojko

2006-01-01

272

Performance of Hydra Probe and MPS-1 Soil Water Sensors in Topsoil Tested in Lab and Field  

OpenAIRE

Soil water sensors are commonly used to monitor water content and matric potential in order to study hydrological processes such as evaporation. Finding a proper sensor is sometimes difficult, especially for measurements in topsoil, where changes of temperature and soil water dynamics occur generally with greater intensity compared to deeper soil layers. We assessed the perfor-mance of Hydra Probe water content sensors and MPS-1 matric potential sensors in topsoil in the lab...

Gerhard Kammerer; Reinhard Nolz; Marek Rodny; Willibald Loiskandl

2014-01-01

273

Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1–C-Mad2 core complex  

OpenAIRE

To satisfy the mitotic checkpoint and drive chromosome congression, the Mps1 kinase lets go of kinetochores by phosphorylating itself in trans (see also related papers by Maciejowski et al. and Santaguida et al. in this issue).

Hewitt, Laura; Tighe, Anthony; Santaguida, Stefano; White, Anne M.; Jones, Clifford D.; Musacchio, Andrea; Green, Stephen; Taylor, Stephen S.

2010-01-01

274

Modelling sustainable development of territorial production systems ????????????? ??????????? ???????? ??????????????? ???????????????? ??????  

OpenAIRE

The article provides an imitation model of stable development of territorial production systems, synthesised with the method of system dynamics, which, unlike the existing ones, has three basic levels – economic, ecological and social, takes into account cyclic fluctuations of external market situation in long-term and short-term periods, and is based on interrelation of stable territorial development with the innovation one. It substantiates structural and process approach to defining stab...

Pashkevich Marina S.; Chernysheva Yelena S.; Gviniashvili Tatyana Z.

2013-01-01

275

Motor Development International: Compressed Air Technology Systems  

Science.gov (United States)

How does a car that boasts "zero pollution" and even "cleans the air it uses" work? This website provides information on the air compression cars developed by Motor Development International. Aside from the general overview of the mechanics of air compression, the FAQ section provides additional information on the air tanks, filter system, body frame, electric system and MDI's business model. A key target for this website seems to be potential buyers and investors.

276

Development of a versatile Raman spectroscopy system  

OpenAIRE

This work describes the development of a facility for the analysis of materials, with particular interest in semiconductors, using Raman spectroscopy. In the apparatus described here a holographic notch filter was used to reject the Rayleigh scattered light, and two different spectrometers were evaluated for spectral analysis of the Raman signal. The first spectrometer was a short focal length (0 lm) system and allowed a portable, compact device to be developed. The second system used a l...

Byrne, Patrick Martin

1998-01-01

277

Development of a simplified piping support system  

International Nuclear Information System (INIS)

This paper presents the results of experimental and analytical studies for developing a simplified piping support system (SPSS) for nuclear power piping in place of snubbers. The basic concept of the SPSS is a passive seismic support system consisting of limit stops. Large gaps are provided to allow for free thermal expansion during normal plant operation while preventing excessive displacement during a seismic event. The results are part of a research and development program sponsored by EPRI. (orig./HP)

278

Development of the stock exchange information system  

OpenAIRE

The stock exchange represents the key institution for the development of capital market of any country. Thus the information system of every stock exchange must satisfy very strict international standards. The development of these systems is particularly difficult in countries in transition, due to intense economic and legal changes, lack of technical and financial resources, lack of experience and knowledge in the area of the capital market business, etc. Therefore the special software proje...

Miladinovi? Radojko

2006-01-01

279

Usability Factors in Information Systems Development  

Directory of Open Access Journals (Sweden)

Full Text Available Computers have become a commonplace technology for today’s man. Computer users demand more reliable and durable interfaces from information processing applications developers. Information systems (ISs research and development, over the years, has been steady so well that the arena has now grown into various subfields such as Cognitive Information Systems (CISs, Web Information Systems(WISs, Geographical Information Systems(GISs, Enterprise Information Systems (EISs, and so forth. Of late, ergonomics specialization too has begun to percolate into the field making it more cross-fertilizing with concerns for successful deployment, a win-win model of development and look-and-feel factor in terms of durable usage and usability. The paper presents a novel taxonomy of computer ergonomics.

K. Chandra Sekharaiah

2014-07-01

280

TECHNOLOGY DEVELOPMENT ON THE DUPIC SAFEGUARDS SYSTEM  

International Nuclear Information System (INIS)

A safeguards system has been developed since 1993 in the course of supporting a fuel cycle process to fabricate CANDU fuel with spent PWR fuel (known as Direct Use of PWR spent fuel In CANDU, DUPIC). The major safeguards technology involved here was to design and fabricate a neutron coincidence counting system for process accountability, and also an unattended continuous monitoring system in association with independent verification by the IAEA. This combined technology was to produce information of nuclear material content and to maintain knowledge of the continuity of nuclear material flow. In addition to hardware development, diagnosis software is being developed to assist data acquisition, data review, and data evaluation based on a neural network system on the IAEA C/S system

281

Hydrogen storage and delivery system development: Fabrication  

Energy Technology Data Exchange (ETDEWEB)

Hydrogen storage and delivery is an important element in effective hydrogen utilization for energy applications and is an important part of the FY1994-1998 Hydrogen Program Implementation Plan. This project is part of the Field Work Proposal entitled Hydrogen Utilization in Internal Combustion Engines (ICE). The goal of the Hydrogen Storage and Delivery System Development Project is to expand the state-of-the-art of hydrogen storage and delivery system design and development. At the foundation of this activity is the development of both analytical and experimental evaluation platforms. These tools provide the basis for an integrated approach for coupling hydrogen storage and delivery technology to the operating characteristics of potential hydrogen energy use applications. Analytical models have been developed for internal combustion engine (ICE) hybrid and fuel cell driven vehicles. The dependence of hydride storage system weight and energy use efficiency on engine brake efficiency and exhaust temperature for ICE hybrid vehicle applications is examined. Results show that while storage system weight decreases with increasing engine brake efficiency energy use efficiency remains relatively unchanged. The development, capability, and use of a newly developed fuel cell vehicle hydride storage system model will also be discussed. As an example of model use power distribution and control for a simulated driving cycle is presented. An experimental test facility, the Hydride Bed Testing Laboratory (HBTL) has been designed and fabricated. The development of this facility and its use in storage system development will be reviewed. These two capabilities (analytical and experimental) form the basis of an integrated approach to storage system design and development. The initial focus of these activities has been on hydride utilization for vehicular applications.

Handrock, J.L.; Malinowski, M.E.; Wally, K. [Sandia National Lab., Livermore, CA (United States)

1996-10-01

282

Modelling energy systems for developing countries  

International Nuclear Information System (INIS)

Developing countries' energy use is rapidly increasing, which affects global climate change and global and regional energy settings. Energy models are helpful for exploring the future of developing and industrialised countries. However, energy systems of developing countries differ from those of industrialised countries, which has consequences for energy modelling. New requirements need to be met by present-day energy models to adequately explore the future of developing countries' energy systems. This paper aims to assess if the main characteristics of developing countries are adequately incorporated in present-day energy models. We first discuss these main characteristics, focusing particularly on developing Asia, and then present a model comparison of 12 selected energy models to test their suitability for developing countries. We conclude that many models are biased towards industrialised countries, neglecting main characteristics of developing countries, e.g. the informal economy, supply shortages, poor performance of the power sector, structural economic change, electrification, traditional bio-fuels, urban-rural divide. To more adequately address the energy systems of developing countries, energy models have to be adjusted and new models have to be built. We therefore indicate how to improve energy models for increasing their suitability for developing countries and give advice on modelling techniques and data requirements. (author)nts. (author)

283

Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress.  

Science.gov (United States)

Aneuploidy is a hallmark of human solid cancers that arises from errors in mitosis and results in gain and loss of oncogenes and tumor suppressors. Aneuploidy poses a growth disadvantage for cells grown in vitro, suggesting that cancer cells adapt to this burden. To understand better the consequences of aneuploidy in a rapidly proliferating adult tissue, we engineered a mouse in which chromosome instability was selectively induced in T cells. A flanked by Lox mutation was introduced into the monopolar spindle 1 (Mps1) spindle-assembly checkpoint gene so that Cre-mediated recombination would create a truncated protein (Mps1(DK)) that retained the kinase domain but lacked the kinetochore-binding domain and thereby weakened the checkpoint. In a sensitized p53(+/-) background we observed that Mps1(DK/DK) mice suffered from rapid-onset acute lymphoblastic lymphoma. The tumors were highly aneuploid and exhibited a metabolic burden similar to that previously characterized in aneuploid yeast and cultured cells. The tumors nonetheless grew rapidly and were lethal within 3-4 mo after birth. PMID:25197064

Foijer, Floris; Xie, Stephanie Z; Simon, Judith E; Bakker, Petra L; Conte, Nathalie; Davis, Stephanie H; Kregel, Eva; Jonkers, Jos; Bradley, Allan; Sorger, Peter K

2014-09-16

284

Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress  

Science.gov (United States)

Aneuploidy is a hallmark of human solid cancers that arises from errors in mitosis and results in gain and loss of oncogenes and tumor suppressors. Aneuploidy poses a growth disadvantage for cells grown in vitro, suggesting that cancer cells adapt to this burden. To understand better the consequences of aneuploidy in a rapidly proliferating adult tissue, we engineered a mouse in which chromosome instability was selectively induced in T cells. A flanked by Lox mutation was introduced into the monopolar spindle 1 (Mps1) spindle-assembly checkpoint gene so that Cre-mediated recombination would create a truncated protein (Mps1DK) that retained the kinase domain but lacked the kinetochore-binding domain and thereby weakened the checkpoint. In a sensitized p53+/? background we observed that Mps1DK/DK mice suffered from rapid-onset acute lymphoblastic lymphoma. The tumors were highly aneuploid and exhibited a metabolic burden similar to that previously characterized in aneuploid yeast and cultured cells. The tumors nonetheless grew rapidly and were lethal within 3–4 mo after birth. PMID:25197064

Foijer, Floris; Xie, Stephanie Z.; Simon, Judith E.; Bakker, Petra L.; Conte, Nathalie; Davis, Stephanie H.; Kregel, Eva; Jonkers, Jos; Bradley, Allan; Sorger, Peter K.

2014-01-01

285

System analysis: Developing tools for the future  

Energy Technology Data Exchange (ETDEWEB)

This report introduces and evaluates system analysis tools that were developed, or are under development, for the Robotics Technology Development Program (RTDP). Additionally, it discusses system analysis work completed using these tools aimed at completing a system analysis of the retrieval of waste from underground storage tanks on the Hanford Reservation near Richland, Washington. The tools developed and evaluated include a mixture of commercially available tools adapted to RTDP requirements, and some tools developed in house. The tools that are included in this report include: a Process Diagramming Tool, a Cost Modeling Tool, an Amortization Modeling Tool, a graphical simulation linked to the Cost Modeling Tool, a decision assistance tool, and a system thinking tool. Additionally, the importance of performance testing to the RTDP and the results of such testing executed is discussed. Further, the results of the Tank Waste Retrieval (TWR) System Diagram, the TWR Operations Cost Model, and the TWR Amortization Model are presented, and the implication of the results are discussed. Finally, the RTDP system analysis tools are assessed and some recommendations are made regarding continuing development of the tools and process.

De Jong, K.; clever, J.; Draper, J.V.; Davies, B.; Lonks, A.

1996-02-01

286

Melanin Biosynthesis in the Maize Pathogen Cochliobolus heterostrophus Depends on Two Mitogen-Activated Protein Kinases, Chk1 and Mps1, and the Transcription Factor Cmr1? †  

OpenAIRE

The maize pathogen Cochliobolus heterostrophus requires two mitogen-activated protein kinases (MAPKs), Chk1 and Mps1, to produce normal pigmentation. Young colonies of mps1 and chk1 deletion mutants have a white and autolytic appearance, which was partially rescued by a hyperosmotic environment. We isolated the transcription factor Cmr1, an ortholog of Colletotrichum lagenarium Cmr1 and Magnaporthe grisea Pig1, which regulates melanin biosynthesis in C. heterostrophus. Deletion of CMR1 in C. ...

Eliahu, Noa; Igbaria, Aeid; Rose, Mark S.; Horwitz, Benjamin A.; Lev, Sophie

2007-01-01

287

Therapeutic Efficacy of Bone Marrow Transplant, Intracranial AAV-mediated Gene Therapy, or Both in the Mouse Model of MPS IIIB  

OpenAIRE

Sanfilippo syndrome type B (MPS IIIB) is a lysosomal storage disease resulting from a deficiency of N-acetyl-glucosaminidase (NAGLU) activity. In an attempt to correct the disease in the murine model of MPS IIIB, neonatal mice were treated with intracranial AAV2/5-NAGLU (AAV), syngeneic bone marrow transplant (BMT), or both (AAV/BMT). All treatments resulted in some improvement in clinical phenotype. Adeno-associated viral (AAV) treatment resulted in improvements in lifespan, motor function, ...

Heldermon, Coy D.; Ohlemiller, Kevin K.; Herzog, Erik D.; Vogler, Carole; Qin, Elizabeth; Wozniak, David F.; Tan, Yun; Orrock, John L.; Sands, Mark S.

2010-01-01

288

Motivating Potential Score (MPS) Determination Using By Job Characteristics And Its Relationship With Job Satisfaction Among Headquarters Staffs Of Tehran University Of Medical Sciences  

OpenAIRE

Background and Aim: Motivation and satisfaction of manpower are the most important variables in the field of organizational behavior and because of the strong relationship between these two variables with the job and organization productivity, it’s necessary to look job characteristics as increasing factor of employee satisfaction and performance in redesigning jobs. The objective of this study was determining motivating potential score (MPS) of the jobs and survey the relation between MPS ...

Azadeh Ahmadzadeh Ghasab; Majid Heydari; Mohammad Ali Abbasi Moghaddam

2013-01-01

289

Method for Planning Administrative Information Systems Development.  

Science.gov (United States)

A methodology to assist decision making about the relative priorities of alternative projects developed at the University of Western Ontario is described. The method identifies the principal options for information systems development and permits application of executive judgment to the strategic importance of competing projects. (Author/MSE)

Bent, Dale; Enright, William

1990-01-01

290

ASSESSING RISKS TO THE DEVELOPING IMMUNE SYSTEM  

Science.gov (United States)

There is no standardized laboratory animal testing approach to assess the potential toxicity of chemicals to the developing immune system. The goal of this research is to apply a panel of in vivo, ex vivo and in vitro assays to determine whether the developing (i.e., prenatal, n...

291

INDUSTRIAL RESEARCH AND DEVELOPMENT INFORMATION SYSTEM (IRIS)  

Science.gov (United States)

The National Science Foundation's (NSF) Industrial Research and Development Information System (IRIS) links an online interface to a historical database with more than 2,500 statistical tables containing all industrial research and development (R&D) data published by NSF since 19...

292

Developing a Mobile Distance Learning System  

OpenAIRE

This article considers the basic problems of client-server electronic learning systems based on mobile platforms. Such questions as relational learning course model and student’s transitions prediction through the learning course items are considered. Besides, technical questions of electronic learning system “E-Learning Suite” realization and questions of developing portable applications using .NET Framework are discussed.

Rogov, Petr; Borisov, Nikolay

2007-01-01

293

Development of advanced gas turbine systems  

Energy Technology Data Exchange (ETDEWEB)

The objective of the Advanced Turbine Systems study is to investigate innovative natural gas fired cycle developments to determine the feasibility of achieving 60% efficiency within a 8-year time frame. The potential system was to be environmentally superior, cost competitive and adaptable to coal-derived fuels. Progress is described.

Bannister, R.L.; Little, D.A.; Wiant, B.C.

1993-11-01

294

Spyder: a reconfigurable processor development system  

OpenAIRE

The Spyder project consists of the development of a reconfigurable processor as well as its application development environment. The name Spyder is an anagram of the first letters of "REconfigurable Processor Development SYstem", where the term reconfigurable means that the hardware of the processor can be specifically tailored for each application. Augmenting the performance of a processor implies either increasing its clock frequency or modifying its architecture. In the latter case, the so...

Iseli, Christian

2007-01-01

295

Development of reactor core channel inspection system  

International Nuclear Information System (INIS)

Inservice inspection of reactor coolant channels is essential to provide assurance of continued structural integrity of pressure tubes over reactor life. A channel inspection system (BARCIS) for inservice inspection of coolant channels of 235 MWe PHWRs has been developed. The system is designed with the aim to minimise radiation exposure to inspection personnel and to perform the inspection so as to minimise reactor downtime. Sixteen channels of RAPS-2 were recently inspected using BARCIS Mark I system. (author). 5 figs

296

The Development of Computer Music Programming Systems  

OpenAIRE

This article traces the history and evolution of Music Programming, from the early off-line synthesis programs of the MUSIC N family to modern realtime interactive systems. It explores the main design characteristics of these systems and their impact on Computer Music. In chronological fashion, the article will examine, with code examples, the development of the early systems into the most common modern languages currently in use. In particular, we will focus on Csound, highlighting its main ...

Lazzarini, Victor

2013-01-01

297

Monopolar spindle 1 (MPS1) kinase promotes production of closed MAD2 (C-MAD2) conformer and assembly of the mitotic checkpoint complex.  

Science.gov (United States)

MPS1 kinase is an essential component of the spindle assembly checkpoint (SAC), but its functioning mechanisms are not fully understood. We have shown recently that direct interaction between BUBR1 and MAD2 is critical for assembly and function of the human mitotic checkpoint complex (MCC), the SAC effector. Here we report that inhibition of MPS1 kinase activity by reversine disrupts BUBR1-MAD2 as well as CDC20-MAD2 interactions, causing premature activation of the anaphase-promoting complex/cyclosome. The effect of MPS1 inhibition is likely due to reduction of closed MAD2 (C-MAD2), as expressing a MAD2 mutant (MAD2(L13A)) that is locked in the C conformation rescued the checkpoint defects. In the presence of reversine, exogenous C-MAD2 does not localize to unattached kinetochores but is still incorporated into the MCC. Contrary to a previous report, we found that sustained MPS1 activity is required for maintaining both the MAD1·C-MAD2 complex and open MAD2 (O-MAD2) at unattached kinetochores to facilitate C-MAD2 production. Additionally, mitotic phosphorylation of BUBR1 is also affected by MPS1 inhibition but seems dispensable for MCC assembly. Our results support the notion that MPS1 kinase promotes C-MAD2 production and subsequent MCC assembly to activate the SAC. PMID:24151075

Tipton, Aaron R; Ji, Wenbin; Sturt-Gillespie, Brianne; Bekier, Michael E; Wang, Kexi; Taylor, William R; Liu, Song-Tao

2013-12-01

298

Development of cask and transportation system  

International Nuclear Information System (INIS)

The major goal of this project is to establish the safe transport system and obtain the necessary data for cask development by during research work for the design and safety test of shipping cask. The analysis technique using computer code for design has been studied in the field of structure, thermal and shielding analysis in this study. And also the test and measurement technology was developed for the measuring system of drop and fire test. It is expected that research activity ensured in this job will enable us to ultilize the basic data for the cask development. (Author)

299

development of new dosimetry system using alanine  

International Nuclear Information System (INIS)

The application of nuclear technology in several industrial fields (food, pharmaceutical, biological,), including sterilization of para-pharmaceutical use and conservation of food irradiation, is becoming more widespread during the last decade. Alongside the development of ionization techniques, the development of dosimetry systems for simple routine use is necessary. The aim of this master project is to develop a new dosimetry system for secondary high-performance control radiation doses applied to different matrices, using the spectrophotometric technique as an alternative of the electron paramagnetic resonance spectroscopy (ESR).

300

The HS6000/20 development system  

International Nuclear Information System (INIS)

In the actual control system of MEA, NIKHEF-K three color displays are in use for graphical representation of the accelerator status information. At the moment the quality of the color displays is bad. The HS6000 development system of the English company Syntel seems to offer a possible solution to replace these displays. In the development system software is developed which finally may run on a target module. The target module, consisting of a processor card with memory and RS232 port and a graphical card, takes care for the control of a color display. The institute has disposed of an experimental set up during two weeks in order to investigate the possibilities and limitations of the development system. The HS6000 development system runs under the OS-9 multi-user and multi-tasking operating system. The operating system takes care for a part of the necessary software to render a computer valuable. The OS-9 operating system disposes of about 60 utility commands. A feature of OS-9 is the application of modular software technique which are based upon memory modules. The interface between the user and the internal functions of the operating system is formed from the shell, the OS-9 command-interpreter code. The software, which has to run on the target module, is written with the help of the Mmacs screen editor, the draw program and the medit editor. The draw program and the medit editor form part of the EGOS ( Enhanced Graphical Output Software) packet. The EGOS packet is a multi-tasking graphical interface for the OS-9 operating system. (author). 1 fig

301

The development of air cooled condensation systems  

International Nuclear Information System (INIS)

EGI - Contracting/Engineering has had experience with the development of air cooled condensing systems since the 1950's. There are two accepted types of dry cooling systems,the direct and the indirect ones. Due to the fact that the indirect system has several advantages over the direct one, EGI's purpose was to develop an economic, reliable and efficient type of indirect cooling system, both for industrial and power station applications. Apart from system development, the main components of dry cooling plant have been developed as well. These are: the water-to-air heat exchangers; the direct contact (DC, or jet) condenser; the cooling water circulating pumps and recovery turbines; and the peak cooling/preheating units. As a result of this broad development work which was connected with intensive market activity, EGI has supplied about 50% of the dry cooling plants employed for large power stations all over the world. This means that today the cumulated capacity of power units using Heller type dry cooling systems supplied and contracted by EGI is over 6000 MW

302

Information Systems Development Methodolgies in Developing Higher Education  

Directory of Open Access Journals (Sweden)

Full Text Available Studies concerned with the status of Information Systems Development Methodologies usage in many developing countries including the factors that influence and motivate their use, current trends, difficulties, and barriers to adoption are lacking, especially within the higher education sector. This paper examines these identified gaps in a developing country, namely the United Arab Emirates. The initial findings reveal that there is limited knowledge and understanding of the concept of ISDM in federal higher education institutions in the UAE. This is reflected in the quality of the software products being developed and released. However, the analysed data also reveals a trend whereby federal higher education institutions in the UAE are gradually moving towards increased ISDM adoption and deployment.

Adam Marks

2012-02-01

303

The engineering of microprocessor systems guidelines on system development  

CERN Document Server

The Engineering of Microprocessor Systems: Guidelines on System Development provides economical and technical guidance for use when incorporating microprocessors in products or production processes and assesses the alternatives that are available. This volume is part of Project 0251 undertaken by The Electrical Research Association, which aims to give managers and development engineers advice and comment on the development process and the hardware and software needed to support the engineering of microprocessor systems. The results of Phase 1 of the five-phase project are contained in this fir

1979-01-01

304

Proximity sensor system development. CRADA final report  

International Nuclear Information System (INIS)

Lockheed Martin Energy Research Corporation (LMERC) and Merritt Systems, Inc. (MSI) entered into a Cooperative Research and Development Agreement (CRADA) for the development and demonstration of a compact, modular proximity sensing system suitable for application to a wide class of manipulator systems operated in support of environmental restoration and waste management activities. In teleoperated modes, proximity sensing provides the manipulator operator continuous information regarding the proximity of the manipulator to objects in the workspace. In teleoperated and robotic modes, proximity sensing provides added safety through the implementation of active whole arm collision avoidance capabilities. Oak Ridge National Laboratory (ORNL), managed by LMERC for the United States Department of Energy (DOE), has developed an application specific integrated circuit (ASIC) design for the electronics required to support a modular whole arm proximity sensing system based on the use of capacitive sensors developed at Sandia National Laboratories. The use of ASIC technology greatly reduces the size of the electronics required to support the selected sensor types allowing deployment of many small sensor nodes over a large area of the manipulator surface to provide maximum sensor coverage. The ASIC design also provides a communication interface to support sensor commands from and sensor data transmission to a distributed processing system which allows modular implementation and operation of the sensor system. MSI is a commercial small business specializing in proximity sensing systems based upon infrared and acoustic sensors

305

System model development for nuclear thermal propulsion  

Science.gov (United States)

A critical enabling technology in the evolutionary development of nuclear thermal propulsion (NTP) is the ability to predict the system performance under a variety of operating conditions. This is crucial for mission analysis and for control subsystem testing as well as for the modeling of various failure modes. Performance must be accurately predicted during steady-state and transient operation, including startup, shutdown, and post operation cooling. The development and application of verified and validated system models has the potential to reduce the design, testing, and cost and time required for the technology to reach flight-ready status. Since Oct. 1991, the U.S. Department of Energy (DOE), Department of Defense (DOD), and NASA have initiated critical technology development efforts for NTP systems to be used on Space Exploration Initiative (SEI) missions to the Moon and Mars. This paper presents the strategy and progress of an interagency NASA/DOE/DOD team for NTP system modeling. It is the intent of the interagency team to develop several levels of computer programs to simulate various NTP systems. The first level will provide rapid, parameterized calculations of overall system performance. Succeeding computer programs will provide analysis of each component in sufficient detail to guide the design teams and experimental efforts. The computer programs will allow simulation of the entire system to allow prediction of the integrated performance. An interagency team was formed for this task to use the best capabilities available and to assure appropriate peer review.

Walton, James T.; Hannan, Nelson A.; Perkins, Ken R.; Buksa, John H.; Worley, Brian A.; Dobranich, Dean

1992-01-01

306

System model development for nuclear thermal propulsion  

International Nuclear Information System (INIS)

A critical enabling technology in the evolutionary development of nuclear thermal propulsion (NTP) is the ability to predict the system performance under a variety of operating conditions. This is crucial for mission analysis and for control subsystem testing as well as for the modeling of various failure modes. Performance must be accurately predicted during steady-state and transient operation, including startup, shutdown, and post operation cooling. The development and application of verified and validated system models has the potential to reduce the design, testing, and cost and time required for the technology to reach flight-ready status. Since Oct. 1991, the U.S. Department of Energy (DOE), Department of Defense (DOD), and NASA have initiated critical technology development efforts for NTP systems to be used on Space Exploration Initiative (SEI) missions to the Moon and Mars. This paper presents the strategy and progress of an interagency NASA/DOE/DOD team for NTP system modeling. It is the intent of the interagency team to develop several levels of computer programs to simulate various NTP systems. The first level will provide rapid, parameterized calculations of overall system performance. Succeeding computer programs will provide analysis of each component in sufficient detail to guide the design teams and experimental efforts. The computer programs will allow simulation of the entire system to allow prediction of the integrated performance. An interagency he integrated performance. An interagency team was formed for this task to use the best capabilities available and to assure appropriate peer review

307

First human treatment with investigational rhGUS enzyme replacement therapy in an advanced stage MPS VII patient.  

Science.gov (United States)

Mucopolysaccharidosis type VII (MPS VII, Sly syndrome) is a very rare lysosomal storage disease caused by a deficiency of the enzyme ?-glucuronidase (GUS), which is required for the degradation of three glycosaminoglycans (GAGs): dermatan sulfate, heparan sulfate, and chondroitin sulfate. Progressive accumulation of these GAGs in lysosomes leads to increasing dysfunction in numerous tissues and organs. Enzyme replacement therapy (ERT) has been used successfully for other MPS disorders, but there is no approved treatment for MPS VII. Here we describe the first human treatment with recombinant human GUS (rhGUS), an investigational therapy for MPS VII, in a 12-year old boy with advanced stage MPS VII. Despite a tracheostomy, nocturnal continuous positive airway pressure, and oxygen therapy, significant pulmonary restriction and obstruction led to oxygen dependence and end-tidal carbon dioxide (ETCO2) levels in the 60-80mmHg range, eventually approaching respiratory failure (ETCO2 of 100mmHg) and the need for full-time ventilation. Since no additional medical measures could improve his function, we implemented experimental ERT by infusing rhGUS at 2mg/kg over 4h every 2weeks for 24weeks. Safety was evaluated by standard assessments and observance for any infusion associated reactions (IARs). Urinary GAG (uGAG) levels, pulmonary function, oxygen dependence, CO2 levels, cardiac valve function, liver and spleen size, and growth velocity were assessed to evaluate response to therapy. rhGUS infusions were well tolerated. No serious adverse events (SAEs) or IARs were observed. After initiation of rhGUS infusions, the patient's uGAG excretion decreased by more than 50%. Liver and spleen size were reduced within 2weeks of the first infusion and reached normal size by 24weeks. Pulmonary function appeared to improve during the course of treatment based on reduced changes in ETCO2 after off-ventilator challenges and a reduced oxygen requirement. The patient regained the ability to eat orally, gained weight, and his energy and activity levels increased. Over 24weeks, treatment with every-other-week infusions of rhGUS was well tolerated with no SAEs, IARs, or hypersensitivity reactions and was associated with measurable improvement in objective clinical measures and quality of life. PMID:25468648

Fox, Joyce E; Volpe, Linda; Bullaro, Josephine; Kakkis, Emil D; Sly, William S

2014-11-01

308

The development of ZPRL digital control system  

International Nuclear Information System (INIS)

Zero Power Reactor at Lung-Tan (ZPRL) is a small open-pool type research reactor located at Lung-Tan, Taiwan. The reactor achieved its first criticality in 1971. An analog control system has been used for almost over 20 years and the power regulating function is found gradually out of order. Therefore, we decided to develop a digital control system to replace the existing analog one. A prototype system has been developed and under on-line test now. The proposed ZPRL digital control system consists of three personal computers. These computers are used as (1) operator console, (2) data acquisition and control system, and (3) auxiliary and backup system. The operator console contains all the man-machine interface functions in the form of graphic display. The data acquisition and control system converts the analog signals into digital ones and feeds to the other two computers. The auxiliary and backup system normally emulates a strip chart recorder for the linear and logarithmic neutron powers and also acts as a transient recorder to keep the trace of the operating conditions on demand or when the reactor scrams. On-line test shows that the system does assure a satisfactory performance. It is not only as good as the analog system but also has the advantages of flexibility, testibility, and a user friendly man-machine interface. (author)

309

Development of a change management system  

Science.gov (United States)

The complexity and interdependence of software on a computer system can create a situation where a solution to one problem causes failures in dependent software. In the computer industry, software problems arise and are often solved with 'quick and dirty' solutions. But in implementing these solutions, documentation about the solution or user notification of changes is often overlooked, and new problems are frequently introduced because of insufficient review or testing. These problems increase when numerous heterogeneous systems are involved. Because of this situation, a change management system plays an integral part in the maintenance of any multisystem computing environment. At the NASA Ames Advanced Computational Facility (ACF), the Online Change Management System (OCMS) was designed and developed to manage the changes being applied to its multivendor computing environment. This paper documents the research, design, and modifications that went into the development of this change management system (CMS).

Parks, Cathy Bonifas

1993-01-01

310

Idaho Explosives Detection System: Development and Enhancements  

International Nuclear Information System (INIS)

The Idaho Explosives Detection System (IEDS) was developed at the Idaho National Laboratory (INL) to respond to threats imposed by delivery trucks carrying bulk explosives into military bases. The system consists of two racks, one on each side of a subject vehicle. Each rack includes a neutron generator and an array of sodium iodide (NaI) detectors. The two neutron generators are pulsed and synchronized. A computer connects to the system by Ethernet and is able to control the system remotely. The system was developed to detect bulk explosives in a medium size truck within a 5-minute measurement time. In 2004, a full-scale prototype IEDS system was built for testing and continued development. System performance was successfully tested using different types of real explosives with a variety of cargo at the INL from November 2005 through February 2006. Recently, the first deployable prototype system was constructed and shipped to Wright-Patterson Air Force Base in Ohio and will be in operation by March 2007. The capability of passively detecting radiological material within a delivery truck has also been added

311

Hydrogen storage and delivery system development  

Energy Technology Data Exchange (ETDEWEB)

Hydrogen storage and delivery is an important element in effective hydrogen utilization for energy applications and is an important part of the FY1994-1998 Hydrogen Program Implementation Plan. The purpose of this project is to develop a platform for the engineering evaluation of hydrogen storage and delivery systems with an added focus on lightweight hydride utilization. Hybrid vehicles represent the primary application area of interest, with secondary interests including such items as existing vehicles and stationary uses. The near term goal is the demonstration of an internal combustion engine/storage/delivery subsystem. The long term goal is optimization of storage technologies for both vehicular and industrial stationary uses. In this project an integrated approach is being used to couple system operating characteristics to hardware development. A model has been developed which integrates engine and storage material characteristics into the design of hydride storage and delivery systems. By specifying engine operating parameters, as well as a variety of storage/delivery design features, hydride bed sizing calculations are completed. The model allows engineering trade-off studies to be completed on various hydride material/delivery system configurations. A more generalized model is also being developed to allow the performance characteristics of various hydrogen storage and delivery systems to be compared (liquid, activated carbon, etc.). Many of the features of the hydride storage model are applicable to the development of this more generalized model.

Handrock, J.L.; Wally, K.; Raber, T.N. [Sandia National Labs., Livermore, CA (United States)

1995-09-01

312

NASA Redox Storage System Development Project  

Science.gov (United States)

The Redox Storage System Technology Project was jointly supported by the U.S. Department of Energy and NASA. The objectives of the project were to develop the Redox flow battery concept and to probe its technical and economic viability. The iron and chromium redox couples were selected as the reactants. Membranes and electrodes were developed for the original mode of operating at 25 C with the reactants separated by an ion-exchange membrane. Analytical capabilities and system-level operating concepts were developed and verified in a 1-kW, 13-kWh preprototype system. A subsequent change was made in operating mode, going to 65 C and using mixed reactants. New membranes and a new electrode catalyst were developed, resulting in single cell operation as high as 80 mA/sq cm with energy efficiencies greater than 80 percent. Studies indicate a likely system cost of about $75/kWh. Standard Oil of Ohio (Sohio) has undertaken further development of the Redox system. An exclusive patent license was obtained from NASA by Sohio. Transfer of Redox technology to Sohio is supported by the NASA Technology Utilization Office.

Hagedorn, N. H.

1984-01-01

313

Control Systems for Information Systems Development Projects (Part I)  

Science.gov (United States)

Discusses control of management information systems and finds a similarity in management of research and development activity. Part II will appear in AEDS Journal, Volume 4, number 2, December 1970. (JF)

Dickson, Gary W.

1970-01-01

314

The Guided System Development Framework: Modeling and Verifying Communication Systems  

DEFF Research Database (Denmark)

In a world that increasingly relies on the Internet to function, application developers rely on the implementations of protocols to guarantee the security of data transferred. Whether a chosen protocol gives the required guarantees, and whether the implementation does the same, is usually unclear. The Guided System Development framework contributes to more secure communication systems by aiding the development of such systems. The framework features a simple modelling language, step-wise refinement from models to implementation, interfaces to security verification tools, and code generation from the verified specification. The refinement process carries thus security properties from the model to the implementation. Our approach also supports verification of systems previously developed and deployed. Internally, the reasoning in our framework is based on the Beliefs and Knowledge tool, a verification tool based on belief logics and explicit attacker knowledge.

Carvalho Quaresma, Jose Nuno; Probst, Christian W.

2014-01-01

315

[Therapy for systemic metabolic disorders based on the detection of basic corneal landmarks in childhood].  

Science.gov (United States)

Many systemic lysosomal storage disorders show basic corneal opacities already in childhood. The lysosome is a cell organelle, produced by Golgi's apparatus, that is surrounded by a membrane and contains hydrolytic enzymes that break down food molecules, especially proteins and other complex molecules. The ophthalmologist's precise diagnosis of corneal clouding at the slit-lamp may reveal the correct interpretation of the specific lysosomal storage disorder. It is very important to diagnose such diseases as soon as possible because today the development of systemic enzymatic therapies has broadened the therapeutic armamentarium for the current standard of care. The following corneal landmarks of systemic storage diseases and of the modern systemic therapy are presented: cornea verticillata in Fabry's disease, periodic infusion of alpha-galactosidase a; Kayser-Fleischer's ring in Wilson's disease, zinc, trienetin, low copper diet; multiple, punctiform crystals in cystinosis, cysteamine, Raptor RP 103(DR cysteamine) that reduces the cytotoxity in form of continous dissolving of cystine from lysosome, renal transplantation, haematopoietic stem cell transplantation; peripheral ring, but not true lipid arc, and moderate stromal haze in LCAT-deficiency, injection of recombinant enzyme or of encapsulated LCAT-secreting cells; diffuse stromal haze in mucopolysaccharidoses (MPS). Enzyme replacement therapy is currently indicated for MPS I, MPS II, and MPS VI, haematopoietic stem cell transplantation; painful, bilateral pseudo-dendritic opacities in tyrosinemia type II (eponym: Richner-Hanhart syndrome), low phenylalanine and tyrosine diet result in complete disappearance of corneal alterations with a consecutive painfree period. Strict diet during the whole life is necessary to prevent corneal recurrences and the occurrence of palmo-plantar keratoses. Such therapies can enable the patient to lead an otherwise normal life for decades. PMID:23794426

Lisch, W; Pitz, S; Geerling, G

2013-06-01

316

System Development as a Rational Communicative Process  

Directory of Open Access Journals (Sweden)

Full Text Available System development is a process in which communication plays an important role. Requirements must be elicited from various stakeholders. But stakeholders also make decisions and must understand the consequences thereof. Different viewpoints must be reconciled, and agreements reached. An important assumption we make is that all actions in the development process are (or should be based on rational decisions. The quest for rationality is a driving force behind the communication that takes place within the development process, because it raises issues that may otherwise have remained in the subconsciousness of stakeholders. We zoom in on the role of vagueness in communication, and argue that there are good reasons not to try and formalize things too soon in the development process. The purpose of this paper is to position our ongoing research, encourage discussion about the assumptions we make, and inspire novel approaches to system development. We work towards a comprehensive theory of rational system development, in which due attention is paid to development processes, communication, and the representations used therein.

Gert Veldhuijzen van Zanten

2004-08-01

317

Development of Solar Powered Irrigation System  

Science.gov (United States)

Development of a solar powered irrigation system has been discussed in this paper. This system would be SCADA-based and quite useful in areas where there is plenty of sunshine but insufficient water to carry out farming activities, such as rubber plantation, strawberry plantation, or any plantation, that requires frequent watering. The system is powered by solar system as a renewable energy which uses solar panel module to convert Sunlight into electricity. The development and implementation of an automated SCADA controlled system that uses PLC as a controller is significant to agricultural, oil and gas monitoring and control purpose purposes. In addition, the system is powered by an intelligent solar system in which solar panel targets the radiation from the Sun. Other than that, the solar system has reduced energy cost as well as pollution. The system is equipped with four input sensors; two soil moisture sensors, two level detection sensors. Soil moisture sensor measures the humidity of the soil, whereas the level detection sensors detect the level of water in the tank. The output sides consist of two solenoid valves, which are controlled respectively by two moistures sensors.

Abdelkerim, A. I.; Sami Eusuf, M. M. R.; Salami, M. J. E.; Aibinu, A.; Eusuf, M. A.

2013-12-01

318

Fourth-generation photovoltaic concentrator system development  

Energy Technology Data Exchange (ETDEWEB)

In 1991, under a contract with Sandia for the Concentrator Initiative, the ENTECH team initiated the design and development of a fourth-generation concentrator module. In 1992, Sandia also contracted with ENTECH to develop a new control and drive system for the ENTECH array. This report documents the design and development work performed under both contracts. Manufacturing processes for the new module were developed at the same time under a complementary PVMaT contract with the National Renewable Energy Laboratory. Two 100-kW power plants were deployed in 1995 in Texas using the newly developed fourth-generation concentrator technology, one at the CSW Solar Park near Ft. Davis and one at TUE Energy Park in Dallas. Technology developed under the Sandia contracts has made a successful transition from the laboratory to the production line to the field.

O`Neill, M.J.; McDanal, A.J. [ENTECH, Inc., Dallas-Fort Worth Airport, TX (United States)

1995-10-01

319

Thermal performance advisor expert system development  

International Nuclear Information System (INIS)

In recent years the electric industry has developed an increased interest in improving efficiency of nuclear power plants. EPRI has embarked upon a research project RP2407, Nuclear Plant Performance Improvements which is designed to address needs in this area. One product of this project has been the Thermal Performance Diagnostic Manual for Nuclear Power Plants (NP-4990P). The purpose of this manual is to provide engineering personnel at nuclear power plants with a consistent way in which to identify thermal performance problems. General Physics is also involved in the development of another computer system called Fossil Thermal Performance Advisor (FTPA) which helps operators improve performance for fossil power plants. FTPA is a joint venture between General Physics and New York State Electric and Gas Company. This paper describes both of these computer systems and uses the FTPA as an interesting comparison that illustrates the considerations required for the development of a computer system that effectively addresses the needs of the users

320

Development of an experimental EUVL system  

Science.gov (United States)

An experimental EUVL system has been developed to investigate EUV imaging system design, component fabrication, assembly technique and experimental process. The system includes a laser produced plasma (LPP) source, an ellipsoidal condenser, a transmission mask, a reduced projection optics, and vacuum system. We designed a 10:1 reduction projection optics using Schwarzschild system with spherical mirrors to achieve 0.1?m resolution. The Schwarzschild optics coated with Mo/Si multilayers was assembled with wavefront error (WFE) of 0.014 waves RMS at 632.8nm wavelength under computer-aided alignment method. Using this system a fine pattern of less than 0.25?m covering a 0.1mm diameter image field of view was clearly replicated on resist-coated wafer.

Jin, Chun-shui; Wang, Li-Ping; Zhang, Li-Chao; Lin, Qiang; Pei, Shu; Cao, Jian-Lin

2007-12-01

321

Development of the Hypothalamic Melanocortin System  

Directory of Open Access Journals (Sweden)

Full Text Available The melanocortin system is a critical component of the forebrain and hindbrain regulatory systems involved in energy balance. This system is composed of pro-opiomelanocortin (POMC neurons that act, in part, through the melanocortin-4 receptor (MC4R. Although the importance of the melanocortin system in controlling feeding has been established for two decades, the understanding of the developmental substrates underlying POMC and MC4R neuron development and function has just begun to emerge. The formation of the melanocortin system involves several discrete developmental steps that include the birth and fate specification of POMC- and MC4R-containing neurons and the extension and guidance of POMC axons to their MC4R-expressing target nuclei. Each of these developmental processes appears to require specific sets of genes and developmental cues that include perinatal hormones. Recent evidence has also highlighted the importance of perinatal nutrition in controlling the ultimate architecture of the melanocortin system.

SebastienGBouret

2013-03-01

322

Applying Prolog to Develop Distributed Systems  

CERN Document Server

Development of distributed systems is a difficult task. Declarative programming techniques hold a promising potential for effectively supporting programmer in this challenge. While Datalog-based languages have been actively explored for programming distributed systems, Prolog received relatively little attention in this application area so far. In this paper we present a Prolog-based programming system, called DAHL, for the declarative development of distributed systems. DAHL extends Prolog with an event-driven control mechanism and built-in networking procedures. Our experimental evaluation using a distributed hash-table data structure, a protocol for achieving Byzantine fault tolerance, and a distributed software model checker - all implemented in DAHL - indicates the viability of the approach.

Lopes, Nuno P; Rybalchenko, Andrey; Singh, Atul; 10.1017/S1471068410000360

2010-01-01

323

Status of tethered satellite system (TSS) development  

Science.gov (United States)

The Tethered Satellite System (TSS) is a cooperative space system and science development activity being carried out by the U.S. and Italy. The TSS will involve an instrument-laden satellite that can be deployed from the cargo bay of the Shuttle Orbiter using a long tether to altitudes both above and below that of the Orbiter. This paper discusses the predevelopment activities, development approach and management relationships, current hardware and software designs and interfaces, overall science experiment status and plans, and mission operation planning for the first TSS mission.

Laue, Jay H.

1988-01-01

324

System development and asset management under restructuring  

International Nuclear Information System (INIS)

In many developed countries the electricity infrastructure contains ageing assets. Because of the need of a continuing operation and higher load factors on the network, the opportunities for replacement or refurbishment are limited. These must be regarded as an opportunity to review the structure of the system and to consider the design and development required to meet the new requirements, taking advantage of new available technologies: HVDC, FACTS, cables, etc. The symposium examines assets management issues and assesses strategies for overhauling existing systems, taking into account the impact on market operation, on supply security and environment

325

Remote viewing system development in BNFL  

International Nuclear Information System (INIS)

The application of imaging systems to BNFL's plants is primarily provided by the Company's Engineering Group. Many systems have been developed for active service and several new developments are currently in an advanced stage of implementation. BNFL has acquired extensive experience of remote viewing from a series of projects undertaken for the Sellafield site in West Cumbria. Applications vary in size and complexity, from simple identification of bar-codes to more complex schemes for remotely storing UO3 drums. Some are high speed and highly repetitive, whereas others are low speed but require high precision. In this paper the authors shall outline a selection of current applications. (Author)

326

Remote viewing system development in BNFL  

International Nuclear Information System (INIS)

The application of imaging systems to BNFL's plants is primarily provided by the Company's Engineering Group. Many systems have been developed for active service and several new developments are currently in an advanced stage of implementation. BNFL has acquired extensive experience of remote viewing from a series of projects undertaken for the Sellafield site in West Cumbria. Applications vary in size and complexity, from simple identification of bar-codes to more complex schemes for remotely storing UO3 drums. Some are high speed and highly repetitive, whereas others are low speed but require high precision. In this paper the authors outline a selection of current applications. (UK)

327

Modelling sustainable development of territorial production systems ????????????? ??????????? ???????? ??????????????? ???????????????? ??????  

Directory of Open Access Journals (Sweden)

Full Text Available The article provides an imitation model of stable development of territorial production systems, synthesised with the method of system dynamics, which, unlike the existing ones, has three basic levels – economic, ecological and social, takes into account cyclic fluctuations of external market situation in long-term and short-term periods, and is based on interrelation of stable territorial development with the innovation one. It substantiates structural and process approach to defining stable development, which lies in the basis of modelling and envisages establishment of a balance not only between static above-mentioned levels of territorial production systems, but also between those processes, which take place between these levels. It provides such a list of linear quantitative links between components of a territorial production system, so that in long-term prospective its development could be identified as stable with predominance of innovation production over resource intensive one. It makes a long-term forecast of development of the Dnipropetrivsk oblast on the basis of functioning of the proposed model.? ?????? ???????????? ???????????? ?????? ??????????? ???????? ??????????????? ???????????????? ??????, ??????????????? ??????? ????????? ????????, ???????, ? ??????? ?? ????????????, ????? ??? ???????? ?????? – ?????????????, ????????????? ? ??????????, ????????? ??????????? ????????? ??????????? ???????? ????? ? ???????????? ? ????????????? ????????, ????????? ?? ??????????? ??????????? ???????????????? ???????? ? ?????????????. ????????? ??????????-?????????? ?????? ? ??????????? ??????????? ????????, ??????? ??????? ? ?????? ????????????? ? ??????????????? ???????????? ??????? ?? ?????? ????? ???????????? ?????????????? ???????? ??????????????? ???????????????? ???????, ?? ? ???? ??????????, ??????? ?????????? ????? ????? ????????. ????????? ???????? ?????????????? ????? ????? ????????????? ??????????????? ???????????????? ??????? ????? ???????, ????? ? ???????????? ??????????? ?? ???????? ????? ???? ???????????????? ??? ?????????? ? ????????????? ?????????????? ???????????? ??? ????????????. ?? ?????? ???????????????? ???????????? ?????? ?????? ???????????? ??????? ???????? ???????????????? ???????.

Pashkevich Marina S.

2013-01-01

328

Supporting production system development through Obeya concept  

OpenAIRE

Manufacturing Industry as an important part of European and Swedish economy faces new challenges with the daily growing global competition. An enabler of overcoming these challenges is a rapid transforming to a value-based focus. Investment in innovation tools for production system development is a crucial part of that focus which helps the companies to rapidly adapt their production systems to new changes. Those changes can be categorized to incremental and radical ones. In this research we ...

Shahbazi, Sasha; Javadi, Siavash

2013-01-01

329

Intrinsic Motivation Systems for Autonomous Mental Development  

OpenAIRE

Exploratory activities seem to be intrinsicallyrewarding for children and crucial for their cognitive development. Can a machine be endowed with such an intrinsic motivation system? This is the question we study in this paper, presenting a number of computational systems that try to capture this drive towards novel or curious situations. After discussing related research coming from developmental psychology, neuroscience, developmental robotics and active learning, this article presents the m...

Oudeyer, Pierre-yves; Kaplan, Frederic; Hafner, Verena

2007-01-01

330

Health Care System Reforms in Developing Countries  

OpenAIRE

This article proposes a critical but non-systematic review of recent health care system reforms in developing countries. The literature reports mixed results as to whether reforms improve the financial protection of the poor or not. We discuss the reasons for these differences by comparing three representative countries: Mexico, Vietnam, and China. First, the design of the health care system reform, as well as the summary of its evaluation, is briefly described for each country. Then, the dis...

Han, Wei

2012-01-01

331

Health care system reform in developing countries  

OpenAIRE

This article proposes a critical but non-systematic review of recent health care system reforms in developing countries. The literature reports mixed results as to whether reforms improve the financial protection of the poor or not. We discuss the reasons for these differences by comparing three representative countries: Mexico, Vietnam, and China. First, the design of the health care system reform, as well as the summary of its evaluation, is briefly described for each country. Then, the dis...

Wei Han

2012-01-01

332

The development of the Finnish energy system  

Energy Technology Data Exchange (ETDEWEB)

The development of the Finnish energy system since the first oil crisis has been both economically and technically well balanced, mainly because of a successful and active energy policy as well as carefully planned responses to external driving forces. The production and distribution system is up-to-date and technologically advanced, supplying good quality energy with high efficiency and at competitive prices. Many economical and technical indicators compare well with ELT and OECD average values.

Kara, M.; Tuhkanen, S.

2002-07-01

333

DEVELOPMENT AND MARKET OF ERP SYSTEMS  

OpenAIRE

The business environment’s changes occurring more and more quickly and company activities’ becoming more and more complex require permanent, fast adjustments which often test human factors’ abilities for efforts and analyses. The creation and development of ERP-type systems have been and are still believed to be the solutions of such challenges ensuring certain support to process large amounts of data and information needed in companies’ decision-making processes. An ERP system helps ...

DIANA-ELENA CODREANU; CARMEN R?DU?

2012-01-01

334

Mantaining design knowledge in system development  

OpenAIRE

The design knowledge apparatus resulting from large systems prototyping cannot remain a single developer's kept-in-mind experience. Since this information is often hidden into the language used for the prototypical components, we present an approach based on a sharp distinction between the object-oriented language, in which components are described, and the design schema, in which components are assembled into a system. The information related to the design, structure and experienced behavior...

Asirelli, Patrizia; Aquilino, Domenico; Inverardi, Paola

1991-01-01

335

Development of KSTAR Neutral Beam Heating System  

Energy Technology Data Exchange (ETDEWEB)

The prototype components of a neutral beam injection (NBI) system have been developed for the KSTAR, and a capability of the manufactured components has been tested. High power ion source, acceleration power supply, other ion source power supplies, neutralizer, bending magnet for ion beam separation, calorimeter, and cryo-sorption pump have been developed by using the domestic technologies and tested for a neutral beam injection of 8 MW per beamline with a pulse duration of 300 seconds. The developed components have been continuously upgraded to achieve the design requirements. The development technology of high power and long pulse neutral beam injection system has been proved with the achievement of 5.2 MW output for a short pulse length and 1.6 MW output for a pulse length of 300 seconds. Using these development technologies, the domestic NB technology has been stabilized under the development of high power ion source, NB beamline components, high voltage and current power supplies, NB diagnostics, NB system operation and control.

Oh, B. H.; Song, W. S.; Yoon, B. J. (and others)

2007-10-15

336

Development of KSTAR Neutral Beam Heating System  

International Nuclear Information System (INIS)

The prototype components of a neutral beam injection (NBI) system have been developed for the KSTAR, and a capability of the manufactured components has been tested. High power ion source, acceleration power supply, other ion source power supplies, neutralizer, bending magnet for ion beam separation, calorimeter, and cryo-sorption pump have been developed by using the domestic technologies and tested for a neutral beam injection of 8 MW per beamline with a pulse duration of 300 seconds. The developed components have been continuously upgraded to achieve the design requirements. The development technology of high power and long pulse neutral beam injection system has been proved with the achievement of 5.2 MW output for a short pulse length and 1.6 MW output for a pulse length of 300 seconds. Using these development technologies, the domestic NB technology has been stabilized under the development of high power ion source, NB beamline components, high voltage and current power supplies, NB diagnostics, NB system operation and control

337

Development of an omnidirectional vision system  

Directory of Open Access Journals (Sweden)

Full Text Available Omnidirectional vision systems can provide images with a 360° of field of view. For this reason, they can be useful to robotic applications such as navigation, teleoperation and visual servoing. An effective way to construct this type of vision system is by combining lenses and mirrors together resulting on a system that does not require the movement of the camera to the direction of attention of the robot. A typical construction is by mounting a convex mirror in front of a camera aligning the center of the mirror with the optical axis of the camera. The most common convex mirror shapes used are conic, parabolic, hyperbolic and spherical. In this work we present two types of mirror that were constructed: a spherical mirror, used in the initial tests, and a hyperbolic, used for actual robot tasks. The hyperbolic mirror was manufactured using an ultra-precision CNC machine. Additionally, a software was developed to create panoramic and perspective images from the image acquired by the system. This work shows the development of an omnidirectional vision system, presenting the formulation used to determine a suitable mirror shape, the mechanical solutions used to build a fully operational system, and the results of the developed algorithm.

Valdir Grassi Junior

2006-03-01

338

Development of an omnidirectional vision system  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english Omnidirectional vision systems can provide images with a 360° of field of view. For this reason, they can be useful to robotic applications such as navigation, teleoperation and visual servoing. An effective way to construct this type of vision system is by combining lenses and mirrors together resu [...] lting on a system that does not require the movement of the camera to the direction of attention of the robot. A typical construction is by mounting a convex mirror in front of a camera aligning the center of the mirror with the optical axis of the camera. The most common convex mirror shapes used are conic, parabolic, hyperbolic and spherical. In this work we present two types of mirror that were constructed: a spherical mirror, used in the initial tests, and a hyperbolic, used for actual robot tasks. The hyperbolic mirror was manufactured using an ultra-precision CNC machine. Additionally, a software was developed to create panoramic and perspective images from the image acquired by the system. This work shows the development of an omnidirectional vision system, presenting the formulation used to determine a suitable mirror shape, the mechanical solutions used to build a fully operational system, and the results of the developed algorithm.

Valdir, Grassi Junior; Jun, Okamoto Junior.

2006-03-01

339

Proposed tokamak poloidal field system development program  

Energy Technology Data Exchange (ETDEWEB)

A program is proposed to develop poloidal field components for TNS and EPR size tokamak devices and to test these components in realistic circuits. Emphasis is placed upon the development of the most difficult component, the superconducting ohmic-heating coil. Switches must also be developed for testing the coils, and this switching technology is to be extended to meet the requirements for the large scale tokamaks. Test facilities are discussed; power supplies, including a homopolar to drive the coils, are considered; and poloidal field systems studies are proposed.

Rogers, J.D.; Vogel, H.F.; Warren, R.W.; Weldon, D.M.

1977-05-01

340

Developing aircraft photonic networks for airplane systems  

DEFF Research Database (Denmark)

Achieving affordable high speed fiber optic communication networks for airplane systems has proved to be challenging. In this paper we describe a summary of the EU Framework 7 project DAPHNE (Developing Aircraft Photonic Networks). DAPHNE aimed to exploit photonic technology from terrestrial communications networks, and then develop and optimize aircraft photonic networks to take advantage of the potential cost savings. The main areas of emphasis were on: multiplexing networks; providing standard components; simplifying installation; and reducing through life support costs. DAPHNE (fifteen partners from seven nations) finished in February 2013; and was supported by the European Commission?s Seventh Framework Programme, although the consortium members are continuing with in-house developments.

White, Henry J. BAE Systems Ltd.

2013-01-01

341

Proposed tokamak poloidal field system development program  

International Nuclear Information System (INIS)

A program is proposed to develop poloidal field components for TNS and EPR size tokamak devices and to test these components in realistic circuits. Emphasis is placed upon the development of the most difficult component, the superconducting ohmic-heating coil. Switches must also be developed for testing the coils, and this switching technology is to be extended to meet the requirements for the large scale tokamaks. Test facilities are discussed; power supplies, including a homopolar to drive the coils, are considered; and poloidal field systems studies are proposed

342

Development of intelligent supervisory control system  

International Nuclear Information System (INIS)

The objective of the development of an intelligent supervisory control system for next generation plants is enhancement of the operational reliability by applying the recent outcome of artificial intelligence and computer technologies. This system consists of the supervisory control and monitoring for automatic operation, the equipment operation support for historical data management and for test scheduling, the operators' decision making support for accidental plant situations and the human-friendly interface of these support functions. The verification test results showed the validity of the functions realized by this system for the next generation control room. (author)

343

DEVELOPMENT OF INTELLIGENT SECURITY AND AUTOMATION SYSTEM  

Directory of Open Access Journals (Sweden)

Full Text Available Intelligent security and Automation system is a device that intends to solve the security issues and also provides automation facilities. the two aspects of security and automation are distinguished by a selector switch. the goal is to develop an intelligent security & automation system that gives the user complete security and automation services. this system can work in two modes as indoor mode and outdoor mode. in outdoor mode it provides complete security of the user place and in indoor mode, it provides user help and automation services. in indoor mode, it helps user as energy consumption indicator, light and temperature controller, home appliances controller, automatic door bell indicator

Diwakar Saxena, Puneet Bisen, Shashank Bhoyerkar

2012-11-01

344

Development of a decommissioning engineering support system  

International Nuclear Information System (INIS)

Preparations are underway to decommission Fugen nuclear power station. An engineering system to support the decommissioning is being developed to create a dismantling plan using state-of-the-art software such as 3-dimensional (3D) CAD and virtual reality. The system will be used to quantify radioactive waste, to visualize radioactive inventory, to simulate dismantling and to optimize the decommissioning schedule. The system will also be useful to gain public acceptance and has promise for various other purposes such as training in dismantling and to link with remote dismantling machines. (author)

345

Telerobotic work system: Concept development and evolution  

Science.gov (United States)

The basic concept of a telerobotic work system (TWS) consists of two dexterous manipulator arms controlled from a remote station. The term telerobotic describes a system that is a combination of teleoperator control and robotic operation. Work represents the function of producing physical changes. System describes the integration of components and subsystems to effectively accomplish the needed mission. Telerobotics reduces exposure to hazards for flight crewmembers and increases their productivity. The requirements for the TWS are derived from both the mission needs and the functional capabilities of existing hardware and software to meet those needs. The development of the TWS is discussed.

Jenkins, Lyle M.

1987-01-01

346

Thermal Protection System (Heat Shield) Development - Advanced Development Project  

Science.gov (United States)

The Orion Thermal Protection System (TPS) ADP was a 3 1/2 year effort to develop ablative TPS materials for the Orion crew capsule. The ADP was motivated by the lack of available ablative TPS's. The TPS ADP pursued a competitive phased development strategy with succeeding rounds of development, testing and down selections. The Project raised the technology readiness level (TRL) of 8 different TPS materials from 5 different commercial vendors, eventual down selecting to a single material system for the Orion heat shield. In addition to providing a heat shield material and design for Orion on time and on budget, the Project accomplished the following: 1) Re-invigorated TPS industry & re-established a NASA competency to respond to future TPS needs; 2) Identified a potentially catastrophic problem with the planned MSL heat shield, and provided a viable, high TRL alternate heat shield design option; and 3) Transferred mature heat shield material and design options to the commercial space industry, including TPS technology information for the SpaceX Dragon capsule.

Kowal, T. John

2010-01-01

347

Oral health care systems in developing and developed countries  

DEFF Research Database (Denmark)

Health care systems are essential for promoting, improving and maintaining health of the population. Through an efficient health service, patients can be advised of disease that may be present and so facilitate treatment; risks factors whose modification could reduce the incidence of disease and illness in the future can be identified, and further, how controlling such factors can contribute to maintain a good quality of life. In developed countries, clinics or hospitals may be supported by health professionals from various specialties that allow their cooperation to benefit the patient; these institutions or clinics may be equipped with the latest technical facilities. In developing countries, health services are mostly directed to provide emergency care only or interventions towards certain age group population. The most common diseases are dental caries and periodontal disease and frequently intervention procedures aim, at treating existing problems and restore teeth and related structure to normal function. It is unfortunate that the low priority given to oral health hinders acquisition of data and establishment of effective periodontal care programmes in developing countries but also in some developed countries where the periodontal profile is also less than satisfactory. Despite the fact that in several developed countries there are advanced programmes oriented to periodontal disease treatments, the concern is related to the lack of preventive oriented treatments. According to data available on periodontal status of populations from developed countries, despite the number of dentists and trained specialists, dental health professionals do not presently meet adequately the need for prevention, focusing mainly on curative care. The need for strengthening disease prevention and health promotion programmes in order to improve oral health conditions and particularly periodontal status in the majority of countries around the world is evident. Unfortunately, in many countries, the human, financial and material resources are still insufficient to meet the need for oral health care services and to provide universal access, especially in disadvantaged communities, in both developing and developed countries. Moreover, even though the most widespread illnesses are avoidable, not all population groups are well informed about or able to take advantage of the proper measures for oral health promotion. In addition, in many countries, oral health care needs to be fully integrated into national or community health programmes. Improving oral health is a very challenging objective in developing countries, but also in developed countries, especially with the accelerated aging of the population now underway and intensifying over the coming years.

Kandelman, Daniel; Arpin, Sophie

2012-01-01

348

Development of a thermoluminescent personnel monitoring system  

International Nuclear Information System (INIS)

Thermoluminescent personnel monitoring system has been developed by the Division of Radiological Protection, Bhabha Atomic Research Centre (BARC), Bombay. The system is presently in use for estimation of personnel doses of radiation workers of BARC, other units of the Department of Atomic Energy, and Defence medical units in India. The report gives salient features of the TLD personnel monitoring system. The report discusses design considerations of thermoluminescent dosimetry (TLD) badge for measurement of X and ?;, ? personnel exposures, a filter combination to compensate for energy dependence of the TLD disc and angular dependence of the badge. The badge reader incorporates a semiautomatic mechanical arrangement wherein the TLD cards are read, raising the heater after positioning the TLD discs one by one. Various figures illustrate the mechanical layouts and electronics circuits used in the system. Periodic quality assurance check of the system which ensures a good reproducibility, is also described. (author)

349

Tribes of Users and System Developers  

OpenAIRE

Effective communication is essential for information systems development crossing functional, organisational and national boundaries. As organisations attempt to overcome cultural barriers to communication across the world, communication with colleagues across the corridor remains problematic; cultural barriers between departments remain unchallenged. This paper introduces the concepts of 'culture' and 'tribe' into the discussion of the relationship between business users and information syst...

Sharon Dingley; Hanifa Shah; Paul Colder

2000-01-01

350

Recent developments of the ALPI control system  

International Nuclear Information System (INIS)

This paper presents recent developments of the control system for ALPI, the new superconducting linear accelerator that will begin to operate at L.N.L. next year. Both hardware and software architectures are described and some base choices are discussed. Results of tests performed in the last two years are also reported. (author)

351

Teaching Information Systems Development via Process Variants  

Science.gov (United States)

Acquiring the knowledge to assemble an integrated Information System (IS) development process that is tailored to the specific needs of a project has become increasingly important. It is therefore necessary for educators to impart to students this crucial skill. However, Situational Method Engineering (SME) is an inherently complex process that…

Tan, Wee-Kek; Tan, Chuan-Hoo

2010-01-01

352

Developing a solar panel testing system  

Directory of Open Access Journals (Sweden)

Full Text Available Solar energy is increasingly used togenerate electricity for individual households. There isa wide variety of solar panel technologies, whichshould be tested at an individual level during theirlifetime. In this paper, the development of a testingstation at the University of Debrecen is presented. Thetesting system can be used for research andeducational purposes and for in field applicationsequally well.

Árpád Rácz

2009-10-01

353

PROFIBUS development for INDUS-2 control system  

International Nuclear Information System (INIS)

This paper describes the hardware and Software development for implementing PROFIBUS for the Indus-2 Control System. PROFIBUS has emerged as vendor independent, versatile field bus communication standards. Accelerators typically present an electromagnetically noisy environment; use of PROFIBUS in such an environment is going to provide reliable and efficient data exchange over long distances. (author)

354

MPACT Fast Neutron Multiplicity System Prototype Development  

Energy Technology Data Exchange (ETDEWEB)

This document serves as both an FY2103 End-of-Year and End-of-Project report on efforts that resulted in the design of a prototype fast neutron multiplicity counter leveraged upon the findings of previous project efforts. The prototype design includes 32 liquid scintillator detectors with cubic volumes 7.62 cm in dimension configured into 4 stacked rings of 8 detectors. Detector signal collection for the system is handled with a pair of Struck Innovative Systeme 16-channel digitizers controlled by in-house developed software with built-in multiplicity analysis algorithms. Initial testing and familiarization of the currently obtained prototype components is underway, however full prototype construction is required for further optimization. Monte Carlo models of the prototype system were performed to estimate die-away and efficiency values. Analysis of these models resulted in the development of a software package capable of determining the effects of nearest-neighbor rejection methods for elimination of detector cross talk. A parameter study was performed using previously developed analytical methods for the estimation of assay mass variance for use as a figure-of-merit for system performance. A software package was developed to automate these calculations and ensure accuracy. The results of the parameter study show that the prototype fast neutron multiplicity counter design is very nearly optimized under the restraints of the parameter space.

D.L. Chichester; S.A. Pozzi; J.L. Dolan; M.T. Kinlaw; S.J. Thompson; A.C. Kaplan; M. Flaska; A. Enqvist; J.T. Johnson; S.M. Watson

2013-09-01

355

Development of Human System Integration at NASA  

Science.gov (United States)

Human Systems Integration seeks to design systems around the capabilities and limitations of the humans which use and interact with the system, ensuring greater efficiency of use, reduced error rates, and less rework in the design, manufacturing and operational deployment of hardware and software. One of the primary goals of HSI is to get the human factors practitioner involved early in the design process. In doing so, the aim is to reduce future budget costs and resources in redesign and training. By the preliminary design phase of a project nearly 80% of the total cost of the project is locked in. Potential design changes recommended by evaluations past this point will have little effect due to lack of funding or a huge cost in terms of resources to make changes. Three key concepts define an effective HSI program. First, systems are comprised of hardware, software, and the human, all of which operate within an environment. Too often, engineers and developers fail to consider the human capacity or requirements as part of the system. This leads to poor task allocation within the system. To promote ideal task allocation, it is critical that the human element be considered early in system development. Poor design, or designs that do not adequately consider the human component, could negatively affect physical or mental performance, as well as, social behavior. Second, successful HSI depends upon integration and collaboration of all the domains that represent acquisition efforts. Too often, these domains exist as independent disciplines due to the location of expertise within the service structure. Proper implementation of HSI through participation would help to integrate these domains and disciplines to leverage and apply their interdependencies to attain an optimal design. Via this process domain interests can be integrated to perform effective HSI through trade-offs and collaboration. This provides a common basis upon which to make knowledgeable decisions. Finally, HSI must be considered early in the requirements development phase of system design and acquisition. This will provide the best opportunity to maximize return on investment (ROI) and system performance. HSI requirements must be developed in conjunction with capability ]based requirements generation through functional. HSI requirements will drive HSI metrics and embed HSI issues within the system design. After a system is designed, implementation of HSI oversights can be very expensive. An HSI program should be included as an integral part of a total system approach to vehicle and habitat development. This would include, but not limited to, workstation design, D&C development, volumetric analysis, training, operations, and human -robotic interaction. HSI is a necessary process for Human Space Flight programs to meet the Agency Human ]System standards and thus mitigate human risks to acceptable levels. NASA has been involved in HSI planning, procedures development, process, and implementation for many years, and has been building several internal and publicly accessible products to facilitate HSI fs inclusion in the NASA Systems Engineering Lifecycle. Some of these products include: NASA STD 3001 Volumes 1 and 2, Human Integration Design Handbook, NASA HSI Implementation Plan, NASA HSI Implementation Plan Templates, NASA HSI Implementation Handbook, and a 2 ]hour short course on HSI delivered as part of the NASA Space and Life Sciences Directorate Academy. These products have been created leveraging industry best practices and lessons learned from other Federal Government agencies.

Whitmore, Mihriban; McGuire, Kerry; Thompson, Shelby; Vos, Gordon

2012-01-01

356

Controls system developments for the ERL facility  

Energy Technology Data Exchange (ETDEWEB)

The BNL Energy Recovery LINAC (ERL) is a high beam current, superconducting RF electron accelerator that is being commissioned to serve as a research and development prototype for a RHIC facility upgrade for electron-ion collision (eRHIC). Key components of the machine include a laser, photocathode, and 5-cell superconducting RF cavity operating at a frequency of 703 MHz. Starting with a foundation based on existing ADO software running on Linux servers and on the VME/VxWorks platforms developed for RHIC, we are developing a controls system that incorporates a wide range of hardware I/O interfaces that are needed for machine R&D. Details of the system layout, specifications, and user interfaces are provided.

Jamilkowski, J.; Altinbas, Z.; Gassner, D.; Hoff, L.; Kankiya, P.; Kayran, D.; Miller, T.; Olsen, R.; Sheehy, B.; Xu, W.

2011-10-07

357

Development of radiation detection and measurement systems  

International Nuclear Information System (INIS)

This report contains descriptions on the following six items. The first item is the result of a study on CsI(TI) crystals with their light emitting characteristics and the result of a study on plastic scintillators. The second item is the result of a study on advanced radiation detectors and includes experiments for the effect of using a Compton suppressor with an HPGe detector. For the third item, we describe the results of a design work done using EGS4 for a thickness gauge, a density gauge, and a level gauge. The fourth item contains descriptions on the prototype circuit systems developed for a level gauge, a thickness gauge, and for a survey meter. The fifth part contains the computed tomography algorithm and a prototype scanning system developed for a CT system. As the sixth and the last item, we describe the prototype high precision heat source and the prototype heat-voltage converter which we have designed and fabricated

358

Advanced CIDI Emission Control System Development  

Energy Technology Data Exchange (ETDEWEB)

Ford Motor Company, with ExxonMobil and FEV, participated in the Department of Energy's (DOE) Ultra-Clean Transportation Fuels Program with the goal to develop an innovative emission control system for light-duty diesel vehicles. The focus on diesel engine emissions was a direct result of the improved volumetric fuel economy (up to 50%) and lower CO2 emissions (up to 25%) over comparable gasoline engines shown in Europe. Selective Catalytic Reduction (SCR) with aqueous urea as the NOx reductant and a Catalyzed Diesel Particulate Filter (CDPF) were chosen as the primary emission control system components. The program expected to demonstrate more than 90% durable reduction in particulate matter (PM) and NOx emissions on a light-duty truck application, based on the FTP-75 drive cycle. Very low sulfur diesel fuel (<15 ppm-wt) enabled lower PM emissions, reduced fuel economy penalty due to the emission control system and improved long-term system durability. Significant progress was made toward a durable system to meet Tier 2 Bin 5 emission standards on a 6000 lbs light-duty truck. A 40% reduction in engine-out NOx emissions was achieved with a mid-size prototype diesel engine through engine recalibration and increased exhaust gas recirculation. Use of a rapid warm-up strategy and urea SCR provided over 90% further NOx reduction while the CDPF reduced tailpipe PM to gasoline vehicle levels. Development work was conducted to separately improve urea SCR and CDPF system durability, as well as improved oxidation catalyst function. Exhaust gas NOx and ammonia sensors were also developed further. While the final emission control system did not meet Tier 2 Bin 5 NOx after 120k mi of aging on the dynamometer, it did meet the standards for HC, NMOG, and PM, and an improved SCR catalyst was shown to have potential to meet the NOx standard, assuming the DOC durability could be improved further. Models of DOC and SCR function were developed to guide the study of several key design factors for SCR systems and aid in the development of urea control strategy for maximum NOx reduction with minimum NH3 slip. A durable co-fueling system was successfully built and tested, with the help of service station nozzle and dispenser manufacturers, for simultaneous delivery of diesel fuel and aqueous urea to the vehicle. The business case for an aqueous urea infrastructure in the US for light-duty vehicles was explored.

Lambert, Christine

2006-05-31

359

Development of a Universal Waste Management System  

Science.gov (United States)

NASA is working with a number of commercial companies to develop the next low Earth orbit spacecraft. The hardware volume and weight constraints are similar to or greater than those of the Apollo era. This, coupled with the equally demanding cost challenge of the proposed commercial vehicles, causes much of the Environmental Control and Life Support System (ECLSS) designs to be reconsidered. The Waste Collection System (WCS) is within this group of ECLSS hardware. The development to support this new initiative is discussed within. A WCS concept - intended to be common for all the vehicle platforms currently on the drawing board - is being developed. The new concept, referred to as the Universal Waste Management System (UWMS), includes favorable features from previous designs while improving on other areas on previous Space Shuttle and the existing International Space Station (ISS) WCS hardware, as needed. The intent is to build a commode that requires less crew time, improved cleanliness, and a 75% reduction in volume and weight compared to the previous US ISS/Extended Duration Orbitor WCS developed in the 1990s. The UWMS is most similar to the ISS Development Test Objective (DTO) WCS design. It is understood that the most dramatic cost reduction opportunity occurs at the beginning of the design process. To realize this opportunity, the cost of each similar component between the UWMS and the DTO WCS was determined. The comparison outlined were the design changes that would result with the greatest impact. The changes resulted in simplifying the approach or eliminating components completely. This initial UWMS paper will describe the system layout approach and a few key features of major components. Future papers will describe the UWMS functionality, test results, and components as they are developed.

Stapleton, Thomas J.; Baccus, Shelley; Broyan, James L., Jr.

2013-01-01

360

Development of Intellectual Reactor Design System: IRDS  

International Nuclear Information System (INIS)

In the frame of the new theme 'Study of analysis method of new nuclear power systems' admitted in our Reactor system laboratory since FY 1988, a program to develop the Intellectual Reactor Design System (IRDS) in the same spirit as ADES has been established. This report describes the activities related to IRDS performed in FY 1989. One of major activities is drafting IRDS. It reflects the conclusion of the STA ADES committee. The essence is to construct a modular system under the object-oriented programming environment to provide a conversational tool for feasibility study and conceptual design. Along the draft the following items were executed in the FY. For the realization of the conversational tool, a tool for input data generation by an object-oriented programming and another tool like CAD for geometry input data generation by a conversational processing of figures on display were examined. Upon the study how to construct the object-oriented data base, the class and frame structures of the design data base were drafted. As components of the modular system, programming of a neutronics and a thermohydraulics module for feasibility study was started. Also a structure analysis code was studied for conversion. In the coming FY, the computer system which has been composed by a FACOM host machine and terminals or isolated PCs will be exchanged by a SUN work-station linked with the host machine and PCs by an ETHER network. Under the suitable environment, the development of IRDS will be promoted. (author)

361

Development of compact CCTV surveillance system. 'COSMOS'  

International Nuclear Information System (INIS)

The Compact Surveillance and Monitoring System, 'COSMOS' has been developed as a compact, simple, highly reliable CCTV surveillance system. The system is intended to provide a direct replacement for the IAEA Twin Minolta film camera systems. The system consists of a recording unit and a set up/review unit. The recording unit, consisting of a CCD camera module, a 8mm VTR unit, a controller module and a power unit, is contained in a tamper indicating housing. The VTR module of very low power consumption is specially developed for COSMOS capable of battery operation. The system can be operated for three months either by battery without battery change where mains power is not readily available or by AC powers. The field-use model of COSMOS was completed in 1991. The field-evaluation test by the IAEA and JAERI was successfully completed in 1993. The IAEA accepted the COSMOS as a routine-use device in August 1993. This report describes the performance features and IAEA test result of COSMOS. (author)

362

EXPERT SYSTEMS - DEVELOPMENT OF AGRICULTURAL INSURANCE TOOL  

Directory of Open Access Journals (Sweden)

Full Text Available Because of the fact that specialty agricultural assistance is not always available when the farmers need it, we identified expert systems as a strong instrument with an extended potential in agriculture. This started to grow in scale recently, including all socially-economic activity fields, having the role of collecting data regarding different aspects from human experts with the purpose of assisting the user in the necessary steps for solving problems, at the performance level of the expert, making his acquired knowledge and experience available. We opted for a general presentation of the expert systems as well as their necessity, because, the solution to develop the agricultural system can come from artificial intelligence by implementing the expert systems in the field of agricultural insurance, promoting existing insurance products, farmers finding options in depending on their necessities and possibilities. The objective of this article consists of collecting data about different aspects about specific areas of interest of agricultural insurance, preparing the database, a conceptual presentation of a pilot version which will become constantly richer depending on the answers received from agricultural producers, with the clearest exposure of knowledgebase possible. We can justify picking this theme with the fact that even while agricultural insurance plays a very important role in agricultural development, the registered result got from them are modest, reason why solutions need to be found in the scope of developing the agricultural sector. The importance of this consists in the proposal of an immediate viable solution to correspond with the current necessities of agricultural producers and in the proposal of an innovative solution, namely the implementation of expert system in agricultural insurance as a way of promoting insurance products. Our research, even though it treats the subject at an conceptual level, it wants to undertake an attempt to present the necessity and importance of implementing expert systems in agricultural insurance as a solution of development of the Romanian agricultural sector since insurance play an important role in the stimulation of investments in agriculture and in the stabilization of agricultural producers incomes. The results of the study, at a conceptual level, confirms the necessity of aplying expert systems in agricultural insurance because of the benefits which would be created (informing agricultural producers about the existence and importance of agricultural insurance, the development of the insurance market which would lead to the development of agriculture, creation of new insurance products adapted to the needs of the farmers.

NAN Anca-Petru?a

2013-07-01

363

Development of a digital mammography system  

International Nuclear Information System (INIS)

A digital breast imaging system is under development to provide improved detectability of breast cancer. In previous work, the limitations of screen-film mammography were studied using both theoretical and experimental techniques. Important limitations were found in both the acquisition and the display components of imaging. These have been addressed in the design of a scanned-projection digital mammography system. A high resolution x-ray image intensifier (XRII), optically coupled to a self-scanned linear photodiode array, is used to record the image. Pre- and post-patient collimation virtually eliminates scattered radiation and veiling glare of the XRII with only a 20% increase in dose due to penumbra. Geometric magnification of 1.6 times is employed to achieve limiting spatial resolution of 7 lp/mm. For low-contrast objects as small as 0.1 mm in diameter, the digital system is capable of producing images with higher contrast and signal-to-noise ratio than optimally-exposed conventional film-screen mammography systems. Greater latitude is obtainable on the digital system because of its wide dynamic range and linearity. The slit system is limited due to long image acquisition times, and poor quantum efficiency. This motivated the authors' current work on a slot beam digital mammography system which is based on a fiber-optic x-ray detector. Preliminary results of this system are presented

364

Development of an Integrated Distribution Management System  

Energy Technology Data Exchange (ETDEWEB)

This final report details the components, functionality, costs, schedule and benefits of developing an Integrated Distribution Management System (IDMS) for power distribution system operation. The Distribution Automation (DA) and Supervisory Control and Data Acquisition (SCADA) systems used by electric power companies to manage the distribution of electric power to retail energy consumers are vital components of the Nation’s critical infrastructure. Providing electricity is an essential public service and a disruption in that service, if not quickly restored, could threaten the public safety and the Nation’s economic security. Our Nation’s economic prosperity and quality of life have long depended on the essential services that utilities provide; therefore, it is necessary to ensure that electric utilities are able to conduct their operations safely and efficiently. A fully integrated technology of applications is needed to link various remote sensing, communications and control devices with other information tools that help guide Power Distribution Operations personnel. A fully implemented IDMS will provide this, a seamlessly integrated set of applications to raise electric system operating intelligence. IDMS will enhance DA and SCADA through integration of applications such as Geographic Information Systems, Outage Management Systems, Switching Management and Analysis, Operator Training Simulator, and other Advanced Applications, including unbalanced load flow and fault isolation/service restoration. These apps are capable of utilizing and obtaining information from appropriately installed DER, and by integrating disparate systems, the Distribution Operators will benefit from advanced capabilities when analyzing, controlling and operating the electric system.

Schatz, Joe E.

2010-10-20

365

APS storage ring vacuum system development  

International Nuclear Information System (INIS)

The Advanced Photon Source synchrotron radiation facility, under construction at the Argonne National Laboratory, incorporates a large ring for the storage of 7 GeV positrons for the generation of photon beams for the facility's materials research program. The Storage Ring's 1104 m circumference is divided into 40 sectors which contain vacuum, beam transport, control, rf and insertion device systems. The vacuum system will operate at a pressure of 1 nTorr and is fabricated from aluminum. The system includes distributed NeG pumping, photon absorbers with lumped pumping, beam position monitors, vacuum diagnostics and valving. An overview of the vacuum system design and details of selected development program results are presented. 5 refs

366

Development of the real time monitor system  

International Nuclear Information System (INIS)

Large-scale simulation technique is studied at the Center for Promotion of Computational Science and Engineering (CCSE) for the computational science research in nuclear fields. Visualization and animation processing technique are studied and developed for efficient understanding of simulation results. The real time monitor system, in which on-going simulation results are transferred from a supercomputer or workstation to a graphic workstation and are visualized and recorded, is described in this report. This system is composed of the graphic workstation and the video equipment connected to the network. The control shell programs are the job-execution shell for simulations on supercomputers, the file-transfer shell for output files for visualization, and the shell for starting visualization tools. Special image processing technique and hardware are not necessary in this system and the standard visualization tool AVS and the UNIX commands are used, so that this system can be implemented and applied in various computer environments. (author)

367

Development of fully automatic pipe welding system  

International Nuclear Information System (INIS)

We have succeeded in developing a fully automatic TIG welding system; namely CAPTIG that enables unmanned welding operations from the initial layer to the final finishing layer continuously. This welding system is designed for continuous, multilayered welding of thick and large diameter fixed pipes of nuclear power plants and large-size boiler plants where high-quality welding is demanded. In the tests conducted with this welding system, several hours of continuous unmanned welding corroborated that excellent beads are formed, good results are obtained in radiographic inspection and that quality welding is possible most reliably. This system incorporates a microcomputer for fully automatic controls by which it features a seam tracking function, wire feed position automatic control function, a self-checking function for inter-pass temperature, cooling water temperature and wire reserve. (author)

368

Developing 360 degree feedback system for KINS  

Energy Technology Data Exchange (ETDEWEB)

This project aims to investigate the feasibility of a 360 degree feedback systems for KINS and to design guiding rules and structures in implementing that systems. Literature survey, environmental analysis and questionnaire survey were made to ensure that 360 degree feedback is the right tool to improve performance in KINS. That review leads to conclusion that more readiness and careful feasibility review are needed before implementation of 360 degree feedback in KINS. Further the project suggests some guiding rules that can be helpful for successful implementation of that system in KINS. Those include : start with development, experiment with one department, tie it to a clear organization's goal, train everyone involve, make sure to try that system in an atmosphere of trust.

Han, In Soo; Cheon, B. M.; Kim, T. H.; Ryu, J. H. [Chungman National Univ., Daejeon (Korea, Republic of)

2003-12-15

369

Life support system development in West Germany  

Science.gov (United States)

The delivery of fully qualified Environmental Control and Life Support System (ECLS) flight hardware for the Spacelab Flight Unit was completed in 1979, and the first Spacelab flight is scheduled for mid 1983. With Spacelab approaching its operational stage, ESA has initiated the Follow-on Development Programme. The future evolution of Spacelab elements in a continued U.S./European cooperation is obviously linked to the U.S. STS evolution and leads from the sortie-mode improvements (Initial Step) towards pallet systems and module applications in unmanned and manned space platforms (Medium and Far Term Alternatives). Extensive studies and design work have been accomplished on life support systems for Life Sciences Laboratories (Biorack) in Spacelab (incubators and holding units for low vertebrates). Future long term missions require the implementation of closed loop life support systems and in order to meet the long range development cycle feasibility studies have been performed. Terrestrial applications of the life support technologies developed for space have been successfully implemented.

Skoog, A. Ingemar

370

PLM system support for modular product development  

DEFF Research Database (Denmark)

A modular design strategy both enables, but also demands, parallelism in design activities and collaboration between a diversity of disciplines in companies, which often involves supporting computer-based tools for enhancing interaction, design management, and communication. Product data management (PDM) and product lifecycle management (PLM) systems offer support by automating and managing some of the operational complexity of modular design activities. PLM system tools are used for handling a variety of product definitions, to manage workflow of development activities, and to measure relational properties such as cost and performance. Companies often use a PLM tool for management of CAD files, documents, and drawings, but they do not take advantage of the full potential of the PLM system to support the development activities of modular product designs. The key result of this paper is the description of an empirical tested approach using a visual product architecture representation in combination with a PLM system to support the development of a product family of products. The results from the study encompass new PLM capabilities for handling multiple product structures, visualising multiple architectural views on products, controlling interfaces, and quantifying and communicating the status and progress of product-related resources. © 2014 Elsevier B.V. All rights reserved.

Bruun, Hans Peter Lomholt; Mortensen, Niels Henrik

2014-01-01

371

Development of the Darlington dousing system  

International Nuclear Information System (INIS)

Consolidation of component development programs design optimization strategy and testing experience has resulted in a compact, efficient design for the Darlington Dousing System. As an integral part of the Negative Pressure Containment Concept employed in CANDU multi-unit stations, the role of the Dousing System is to rapidly cool and condense steam drawn into the Vacuum Structure in the event of a Loss of Coolant Accident. Given a Vacuum Structure larger than at other stations, a maximum flowrate target was established to meet safety requirements. The riser pipes and spray plates are sized to meet the peak flow requirement while conserving water for small breaks and maximizing the head available on the spray plates. To improve the thermal utilization of the spray a development program was undertaken which resulted in the design of a novel domed spray plate which exhibited good spray characteristics over a wide range of driving pressures. Loss coefficients for the dousing system were determined in a 1/16 scale model. A computer model of the spray header was developed to optimize spray plate layout for uniform water distribution. Commissioning tests at Pickering and Bruce stations aided in the design and revealed unique dousing characteristics. This includes air entrainment which lowers upper chamber pressure and can lead to over-dousing. System performance is analyzed by a thermal-hydraulic to the rest of containment by the energy removal rate in the Vacuum Structureergy removal rate in the Vacuum Structure

372

Sensor Development for PEM Fuel Cell Systems  

Energy Technology Data Exchange (ETDEWEB)

This document reports on the work done by Honeywell Sensing and Control to investigate the feasibility of modifying low cost Commercial Sensors for use inside a PEM Fuel Cell environment. Both stationary and automotive systems were considered. The target environment is hotter (100 C) than the typical commercial sensor maximum of 70 C. It is also far more humid (100% RH condensing) than the more typical 95% RH non-condensing at 40 C (4% RH maximum at 100 C). The work focused on four types of sensors, Temperature, Pressure, Air Flow and Relative Humidity. Initial design goals were established using a market research technique called Market Driven Product Definition (MDPD). A series of interviews were conducted with various users and system designers in their facilities. The interviewing team was trained in data taking and analysis per the MDPD process. The final result was a prioritized and weighted list of both requirements and desires for each sensor. Work proceeded on concept development for the 4 types of sensors. At the same time, users were developing the actual fuel cell systems and gaining knowledge and experience in the use of sensors and controls systems. This resulted in changes to requirements and desires that were not anticipated during the MDPD process. The concepts developed met all the predicted requirements. At the completion of concept development for the Pressure Sensor, it was determined that the Fuel Cell developers were happy with off-the-shelf automotive pressure sensors. Thus, there was no incentive to bring a new Fuel Cell Specific Pressure Sensor into production. Work was therefore suspended. After the experience with the Pressure Sensor, the requirements for a Temperature Sensor were reviewed and a similar situation applied. Commercially available temperature sensors were adequate and cost effective and so the program was not continued from the Concept into the Design Phase.

Steve Magee; Richard Gehman

2005-07-12

373

Development of the Medium Energy Linac Systems  

International Nuclear Information System (INIS)

The main purpose of this project is developing 100-MeV proton linear accelerator (linac) for proton engineering frontier project (PEFP). In the first phase of the PEFP, the development of the 20-MeV linac has successfully finished. Hence the work scope of this project is designing the linac to accelerate proton beams from 20-MeV up to 100-MeV, fabricating the linac up to 45 MeV, fabricating one set of the medium energy beam transport (MEBT) tank, and developing the low level radio frequency (LLRF) system and the control system. The basic role of the new proton accelerator is accelerating 20-mA proton beams from 20 MeV up to 100 MeV. The first step of the design procedure is optimizing and determining the accelerator parameters. The beam loss is also main concern in the design stage. The drift tube (DT) and the quadrupole magnets are designed to be optimized to the new linac design. The other purpose is confirming the new design by fabricating and tuning the drift tube linac (DTL). The 20MeV proton beam divided into two directions. One is supplying the beams to user group by turning on the 45-degree bending magnet. The other is guided into the 100-MeV DTL by tuning off the dipole magnet. That is why the PEFP MEBT located after 20-MeV DTL. The MEBT is realized as two small DTL tanks with three cells and a 45-degree bending magnet. The fabrication of one MEBT tank is another purpose of this project. The other purposes of this project is developing the LLRF system to control the RF signal and control system to monitor and control the vacuum system, magnet power supply, etc

374

Characterization of the cellular and antitumor effects of MPI-0479605, a small-molecule inhibitor of the mitotic kinase Mps1.  

Science.gov (United States)

Mps1 is a dual specificity protein kinase that is essential for the bipolar attachment of chromosomes to the mitotic spindle and for maintaining the spindle assembly checkpoint until all chromosomes are properly attached. Mps1 is expressed at high levels during mitosis and is abundantly expressed in cancer cells. Disruption of Mps1 function induces aneuploidy and cell death. We report the identification of MPI-0479605, a potent and selective ATP competitive inhibitor of Mps1. Cells treated with MPI-0479605 undergo aberrant mitosis, resulting in aneuploidy and formation of micronuclei. In cells with wild-type p53, this promotes the induction of a postmitotic checkpoint characterized by the ATM- and RAD3-related-dependent activation of the p53-p21 pathway. In both wild-type and p53 mutant cells lines, there is a growth arrest and inhibition of DNA synthesis. Subsequently, cells undergo mitotic catastrophe and/or an apoptotic response. In xenograft models, MPI-0479605 inhibits tumor growth, suggesting that drugs targeting Mps1 may have utility as novel cancer therapeutics. PMID:21980130

Tardif, Keith D; Rogers, Aaron; Cassiano, Jared; Roth, Bruce L; Cimbora, Daniel M; McKinnon, Rena; Peterson, Ashley; Douce, Thomas B; Robinson, Rosann; Dorweiler, Irene; Davis, Thaylon; Hess, Mark A; Ostanin, Kirill; Papac, Damon I; Baichwal, Vijay; McAlexander, Ian; Willardsen, J Adam; Saunders, Michael; Christophe, Hoarau; Kumar, D Vijay; Wettstein, Daniel A; Carlson, Robert O; Williams, Brandi L

2011-12-01

375

Spc24 interacts with Mps2 and is required for chromosome segregation, but is not implicated in spindle pole body duplication.  

Science.gov (United States)

Mps2 (monopolar spindle protein) is a coiled-coil protein found at the spindle pole body (SPB) and at the nuclear envelope that is required for insertion of the SPB into the nuclear envelope. We identified three proteins that interact with Mps2 in a two-hybrid screen: Bbp1, Ynl107w and Spc24. All three proteins contain coiled-coil motifs that appear to be required for their interaction with Mps2. In this work, we verified the Mps2-Spc24 interaction by co-immunoprecipitation in vivo and by the in vitro interaction of recombinant proteins. Previous two-hybrid screens with Spc24 as bait had identified Spc25 and Ndc80 as putative interacting partners, and we verified these interactions in vivo by purification of TAP-tagged derivatives of Spc24 and Ndc80. Finally, we found that spc24 thermosensitive mutants had a chromosome segregation defect, but no apparent defect in SPB duplication. These results are consistent with recently published data showing that Spc24, Spc25 and Ndc80 are peripheral kinetochore com-ponents required for chromosome segregation. The Mps2-Spc24 interaction may contribute to the localization of Spc24 and other kinetochore components to the inner plaque of the SPB. PMID:11952896

Le Masson, Ivan; Saveanu, Cosmin; Chevalier, Anne; Namane, Abdelkader; Gobin, Renée; Fromont-Racine, Micheline; Jacquier, Alain; Mann, Carl

2002-03-01

376

Advanced Turbine Systems Program industrial system concept development  

Energy Technology Data Exchange (ETDEWEB)

The objective of Phase II of the Advanced Turbine Systems Program is to develop conceptual designs of gas fired advanced turbine systems that can be adapted for operation on coal and biomass fuels. The technical, economic, and environmental performance operating on natural gas and in a coal fueled mode is to be assessed. Detailed designs and test work relating to critical components are to be completed and a market study is to be conducted.

Gates, S. [Solar Turbines Inc., San Diego, CA (United States)

1995-10-01

377

Equipment system for advanced nuclear fuel development  

International Nuclear Information System (INIS)

The purpose of the settlement of equipment system for nuclear Fuel Technology Development Facility(FTDF) is to build a seismic designed facility that can accommodate handling of nuclear materials including <20% enriched Uranium and produce HANARO fuel commercially, and also to establish the advanced common research equipment essential for the research on advanced fuel development. For this purpose, this research works were performed for the settlement of radiation protection system and facility special equipment for the FTDF, and the advanced common research equipment for the fuel fabrication and research. As a result, 11 kinds of radiation protection systems such as criticality detection and alarm system, 5 kinds of facility special equipment such as environmental pollution protection system and 5 kinds of common research equipment such as electron-beam welding machine were established. By the settlement of exclusive domestic facility for the research of advanced fuel, the fabrication and supply of HANARO fuel is possible and also can export KAERI-invented centrifugal dispersion fuel materials and its technology to the nations having research reactors in operation. For the future, the utilization of the facility will be expanded to universities, industries and other research institutes

378

Methodology for developing educational hypermedia systems.  

Science.gov (United States)

Hypermedia has the potential to greatly enhance teaching. It can, however, be difficult to develop hyperdocuments which provide medical students with the full benefit of the technology. We wish to resolve this problem by providing a methodology for creating educational hypermedia systems with specific emphasis on the medical domain, but applicable across disciplines. This paper examines some of the specific issues involved in educational hypermedia, and outlines a series of practical guidelines, drawing together the disparate disciplines necessary to the development process. We illustrate the methodology with our own experience in creating and updating the HIV Hypermedia Medical Education Software over a period of two years. PMID:10384554

Bearman, M; Kidd, M; Cesnik, B

1998-01-01

379

BEMS systems give developer sixth sense.  

Science.gov (United States)

Duty-bound under contracts with partner NHS PCTs, independent primary care contractors, and other community stakeholders who lease healthcare premises from it, to ensure that the buildings' energy systems and plant run efficiently and cost-effectively, Community Solutions, a leading investor in, and developer of, UK community-based health, social, and local authority services, is now standardising on Trend Controls' building energy management systems to ensure that such vital equipment runs within defined parameters, and that facilities without FM personnel on site day-to-day are kept both comfortable to work in, and fit-for-purpose. PMID:21859066

Baillie, Jonathan

2011-08-01

380

Diesel starting system monitor: Prototype development  

International Nuclear Information System (INIS)

The US Department of Energy (DOE) effort to extend the operational lives of commercial nuclear power plants is examining methods for predicting the performance of specific equipment. This paper focuses on predictive monitoring as a means for reducing equipment surveillance, maintenance, and outages. Realizing these goals will result in nuclear plants that are more reliable, have lower maintenance costs, and have longer lives. This report describes a prognostic monitoring system that has been developed to predict starting performance in emergency diesels. A prototype system has been built and tested on an engine at Sandia National Laboratories. 6 refs., 8 figs

381

Development of Nuclear Component Reliability Data System  

International Nuclear Information System (INIS)

Nuclear Information Center (NIC) of Central Research Institute of Electric Power Industry (CRIEPI) serves utilities by providing information on operation and maintenance of the nuclear power plants, and evaluating the plant performance and incident trends. As a result of these evaluations, a nuclear component reliability data system has been developed for estimation of failure rate of major components for use in PSA. This paper describes the features of this data system and shows examples of the calculated failure rates for Japanese nuclear power plants

382

Reframing Humans in Information Systems Development  

CERN Document Server

Modern society has been transformed by the digital convergence towards a future where technologies embed themselves into the fabric of everyday life. This ongoing merging of social and technological infrastructures provides and necessitates new possibilities to renovate past notions, models and methods of information systems development that accommodates humans as actors within the infrastructure. This shift introduces new possibilities for information systems designers to fulfil more and more everyday functions, and to enhance their value and worth to the user. "Reframing Humans in Infor

Isomaki, Hannakaisa

2011-01-01

383

Development of intellectual reactor design system IRDS  

International Nuclear Information System (INIS)

An intellectual reactor design system IRDS has been developed as a prototype of the ADES program. The objective is to support feasibility study and pre-conceptual design of new type reactor cores. Design process is achieved by the sequential steps to get/put information from/to design model. It works on an EWS by utilizing its capabilities of menu window display for an interactive usage and of graphic display for a visualization of input and output of simulation. An object oriented architecture is realized in system control, integration of simulation modules, and structure of design data base. (author)

384

Space Launch System Accelerated Booster Development Cycle  

Science.gov (United States)

With the retirement of the Space Shuttle, NASA is seeking to reinvigorate the national space program and recapture the public s interest in human space exploration by developing missions to the Moon, near-earth asteroids, Lagrange points, Mars, and beyond. The would-be successor to the Space Shuttle, NASA s Constellation Program, planned to take humans back to the Moon by 2020, but due to budgetary constraints was cancelled in 2010 in search of a more "affordable, sustainable, and realistic" concept2. Following a number of studies, the much anticipated Space Launch System (SLS) was unveiled in September of 2011. The SLS core architecture consists of a cryogenic first stage with five Space Shuttle Main Engines (SSMEs), and a cryogenic second stage using a new J-2X engine3. The baseline configuration employs two 5-segment solid rocket boosters to achieve a 70 metric ton payload capability, but a new, more capable booster system will be required to attain the goal of 130 metric tons to orbit. To this end, NASA s Marshall Space Flight Center recently released a NASA Research Announcement (NRA) entitled "Space Launch System (SLS) Advanced Booster Engineering Demonstration and/or Risk Reduction." The increased emphasis on affordability is evident in the language used in the NRA, which is focused on risk reduction "leading to an affordable Advanced Booster that meets the evolved capabilities of SLS" and "enabling competition" to "enhance SLS affordability. The purpose of the work presented in this paper is to perform an independent assessment of the elements that make up an affordable and realistic path forward for the SLS booster system, utilizing advanced design methods and technology evaluation techniques. The goal is to identify elements that will enable a more sustainable development program by exploring the trade space of heavy lift booster systems and focusing on affordability, operability, and reliability at the system and subsystem levels5. For this study, affordability is defined as lifecycle cost, which includes design, development, test, and engineering (DDT&E), production and operational costs (P&O). For this study, the system objectives include reducing DDT&E schedule by a factor of three, showing 99.9% reliability, flying up to four times per year, serving both crew and cargo missions, and evolving to a lift capability of 130 metric tons.3 After identifying gaps in the current system s capabilities, this study seeks to identify non-traditional and innovative technologies and processes that may improve performance in these areas and assess their impacts on booster system development. The DDT&E phase may be improved by incorporating incremental development testing and integrated demonstrations to mitigate risk. To further reduce DDT&E, this study will also consider how aspects of the booster system may have commonality with other users, such as the Department of Defense, commercial applications, or international partners; by sharing some of the risk and investment, the overall development cost may be reduced. Consideration is not limited to solid and liquid rocket boosters. A set of functional performance characteristics, such as engine thrust, specific impulse (Isp), mixture ratio, and throttle range are identified and their impacts on the system are evaluated. This study also identifies how such characteristics affect overall life cycle cost, including DDT&E and fixed and variable P&O.

Arockiam, Nicole; Whittecar, William; Edwards, Stephen

2012-01-01

385

Natural history and galsulfase treatment in mucopolysaccharidosis VI (MPS VI, Maroteaux-Lamy syndrome)--10-year follow-up of patients who previously participated in an MPS VI Survey Study.  

Science.gov (United States)

Mucopolysaccharidosis VI (MPS VI) is a clinically heterogeneous and progressive disorder with multiorgan manifestations caused by deficient N-acetylgalactosamine-4-sulfatase activity. A cross-sectional Survey Study in individuals (n?=?121) affected with MPS VI was conducted between 2001 and 2002 to establish demographics, urinary glycosaminoglycan (GAG) levels, and clinical progression of disease. We conducted a Resurvey Study (ClinicalTrials.gov: NCT01387854) to obtain 10-year follow-up data, including medical histories and clinical assessments (n?=?59), and survival status over 12 years (n?=?117). Patients received a mean (SD) of 6.8 (2.2) years of galsulfase ERT between baseline (Survey Study) and follow-up. ERT patients increased in height by 20.4 cm in the 4-7-year-old baseline age group and by 16.8 cm in the 8-12-year-old baseline age group. ERT patients 200 µg/mg baseline uGAG levels increased FVC by 48% in the ERT patients who completed the 6-min walk test demonstrated a mean (SD) increase of 65.7 (100.6) m. Cardiac outcomes did not significantly improve or worsen. Observed mortality rate among naïve patients was 50% (7/14) and 16.5% (17/103) in the ERT group (unadjusted hazard ratio, 0.24; 95% CI, 0.10-0.59). Long-term galsulfase ERT was associated with improvements in pulmonary function and endurance, stabilized cardiac function and increased survival. PMID:24764221

Giugliani, Roberto; Lampe, Christina; Guffon, Nathalie; Ketteridge, David; Leão-Teles, Elisa; Wraith, James E; Jones, Simon A; Piscia-Nichols, Cheri; Lin, Ping; Quartel, Adrian; Harmatz, Paul

2014-08-01

386

Development of technical information processing system (VII)  

International Nuclear Information System (INIS)

The goal of this project is to establish integrated environment focused on enhanced information services to researchers through the providing of acquisition information, key phrase retrieval function, journal content information linked with various subsystems already developed. The results of the project are as follows. 1. It is possible to serve information on unreceivable materials among required materials throughout the system. 2. Retrieval efficiency is increased by the adding of key phrase retrieval function. 3. Rapidity of information service is enhanced by the providing of journal contents of each issue received and work performance of contents service is become higher. 4. It is possible to acquire, store, serve technical information needed in R and D synthetically and systematically throughout the development of total system linked with various subsystems required to technical information management and service. 21 refs. (Author)

387

Development of NMCA system and software  

International Nuclear Information System (INIS)

Full text: Development of the NMCA system in the Institute of Atomic Energy is described. The Institute is the one of research scientific subdivisions of the National Nuclear Center of the Republic of Kazakhstan. Four nuclear facilities in the country is operating. Institute is a facility with two research reactors, located on the remote sites of the former Semipalatinsk nuclear test site. Layouts and main parameters of the reactors are attached. In additional to reactors, NM storages, on-pile stands, research labs and hot cell are located on sites. The NM storing and handling are covered by NMCA system which after USSR disintegration was in a bad condition: on-paper account, lack of personal training, normative documents, measuring system, and access control. After ratification of Safeguards Agreement all Kazakhstan's nuclear facilities became to being inspected by IAEA and State authority. Putting of the NMCA system according to international rules is started. Since 1993 a collaboration with Departments of Defense and Energy is begun, particularly with Los-Alamos, Sandia and Oak-Ridge National labs. Directions of development and needs of technical and methodical assistance were defined. In the following time a computers for account, spectrometric and weighing equipment for NDA, TID and other office equipment were delivered. Development of a number of documents concerning regulation of NM handling, IAEA inspectors cooperation, reporting was conducted under ORNL support. NMCA custodians were participants of many training courses held in Kazakhstan, NIS, LANL, NRC. The computerized NMCA system 'AIMAS' developed in ANL and delivered to the Institute was implemented successfully in 1995. During some followed years the 'AIMAS' system was modified step by step and spread to other nuclear facilities of Kazakhstan and Uzbekistan under DOE support. The important element of supporting of SSAC development in Kazakhstan is funding and providing with methodic of annual workshops-conferences for NMCA custodians from Kazakhstan and Uzbekistan. These meetings are conducted continuously on the all nuclear facilities so that the NMCA specialists have a chance to meet their progress in NMCA area. Last such meeting was conducted in August 2005 at the Institute of Atomic Energy. (author)

388

Development of Alabama Resources Information System (ARIS)  

Science.gov (United States)

A formal, organized set of information concerning the development status of the Alabama Resources Information System (ARIS) as of September 1976 is provided. A series of computer source language programs, and flow charts related to each of the computer programs to provide greater ease in performing future change are presented. Listings of the variable names, and their meanings, used in the various source code programs, and copies of the various user manuals which were prepared through this time are given.

Herring, B. E.; Vachon, R. I.

1976-01-01

389

Development of an aircraft design expert system  

OpenAIRE

The aircraft design process is characterised by the application of a wide range of knowledge across many disciplines based upon a certain degree of judgement and experience of the designer. A two pass approach has been taken towards the development of an aircraft design expert system based on the requirements of two conceptually different design steps namely, wing design and aircraft configuration. The current status of the work is one where an actual program for wing des...

Alsina, J.

1988-01-01

390

Development of cask and transportation system  

International Nuclear Information System (INIS)

Transportation of spent fuels to the AFR interim storage facility and disposal repository are necessary in Korea. Therefore, an emphasis has been concentrated to develop the design and fabrication technology of commercial casks. A conceptual design of the temperature and deformation measuring systems in the cask, which will be used for mock-up tests has been performed. Preliminary design data of the cask for 7 spent PWR fuels have been obtained in the course of study. (author)

391

Development of an automated handwriting analysis system  

OpenAIRE

In the present study a method has been proposed for the behavioral prediction of a person through automated handwriting analysis. The present work identifies the psychological traits in the writing namely size, slant and pressure, baseline, number of breaks, margins, speed of writing and spacing between the words. The handwriting is analyzed through Image Processing in MATLAB. The behavioral pattern of the person is predicted from the above traits of the handwriting. The developed system iden...

Vikram Kamath; Nikhil Ramaswamy; Navin Karanth, P.; Vijay Desai; Kulkarni, S. M.

2011-01-01

392

SNS EXTRACTION FAST KICKER SYSTEM DEVELOPMENT.  

Energy Technology Data Exchange (ETDEWEB)

The SNS Extraction Fast Kicker System is a very high power, high repetition rate pulsed power system. It was design and developed at Brookhaven National Laboratory. This system will consist of fourteen identical high voltage, high current modulators, and their auxiliary control and charging systems. The modulators will drive fourteen extraction magnet sections located inside of the SNS accumulator ring. The required kicker field rise time is 200 ns, a pulse flattop of 700 ns, a pulse repetition rate of 60 pulse-per-second. A 2500 Ampere per modulator output is required to reach the extraction kicker magnetic field strength. This design features a Blumlein Pulse-Forming-Network based topology, a low beam impedance termination, a fast current switching thyratron, and low inductance capacitor banks. It has a maximum charging voltage of 50kV, an open circuit output of 100kV, and a designed maximum pulsed current output of 4kA per modulator. The overall system output will be multiple GVA with 60 Pulse-per-second repetition rate. A prototype modulator has been successfully built and tested well above the SNS requirement. The modulator system production is in progress.

ZHANG,W.; SANDBERG,J.; LAMBIASE,R.; LEE,Y.Y.; LOCKEY,R.; MI,J.; NEHRING,T.; PAI,C.; TSOUPAS,N.; TUOZZOLO,J.; WARBURTON,D.; WEI,J.; RUST,K.; CUTLER,R.

2003-06-15

393

Solar Energy Forecast System Development and Implementation  

Science.gov (United States)

Forecast systems for predicting real-time solar energy generation are being developed along similar lines to those of more established wind forecast systems, but the challenges and constraints are different. Clouds and aerosols play a large role, and for tilted photovoltaic panels and solar concentrating plants, the direct beam irradiance, which typically has much larger forecast errors than global horizontal irradiance, must be utilized. At MDA Information Systems, we are developing a forecast system based on first principles, with the well-validated REST2 clear sky model (Gueymard, 2008) at its backbone. In tuning the model and addressing aerosol scattering and surface albedo, etc., we relied upon the wealth of public data sources including AERONET (aerosol optical depth at different wavelengths), Suominet (GPS integrated water vapor), NREL MIDC solar monitoring stations, SURFRAD (includes upwelling shortwave), and MODIS (albedo in different wavelength bands), among others. The forecast itself utilizes a blend of NWP model output, which must be brought down to finer time resolution based on the diurnal cycle rather than simple interpolation. Many models currently do not output the direct beam irradiance, and one that does appears to have a bias relative to its global horizontal irradiance, with equally good performance attained by utilizing REST2 and the model global radiation to estimate the direct component. We will present a detailed assessment of various NWP solar energy products, evaluating forecast skill at a range of photovoltaic installations.

Jascourt, S. D.; Kirk-Davidoff, D. B.; Cassidy, C.

2012-12-01

394

Development of Sic Gas Sensor Systems  

Science.gov (United States)

Silicon carbide (SiC) based gas sensors have significant potential to address the gas sensing needs of aerospace applications such as emission monitoring, fuel leak detection, and fire detection. However, in order to reach that potential, a range of technical challenges must be overcome. These challenges go beyond the development of the basic sensor itself and include the need for viable enabling technologies to make a complete gas sensor system: electrical contacts, packaging, and transfer of information from the sensor to the outside world. This paper reviews the status at NASA Glenn Research Center of SiC Schottky diode gas sensor development as well as that of enabling technologies supporting SiC gas sensor system implementation. A vision of a complete high temperature microfabricated SiC gas sensor system is proposed. In the long-term, it is believed that improvements in the SiC semiconductor material itself could have a dramatic effect on the performance of SiC gas sensor systems.

Hunter, G. W.; Neudeck, P. G.; Okojie, R. S.; Beheim, G. M.; Thomas, V.; Chen, L.; Lukco, D.; Liu, C. C.; Ward, B.; Makel, D.

2002-01-01

395

System Transfer, Education, and Development in Mozambique  

Directory of Open Access Journals (Sweden)

Full Text Available In this study the author used conceptual historical method to assess the phenomenon of system transfer and the association between education and development in Mozambique. The assessment was administered through critical analysis of documents pertaining to the Salazar (1924-1966, Machel (1975-1986, and Chissano (1986-2005 administrations. The findings were that (a the colonial government created economic and educational systems for colonizing Mozambique, whereas the Machel and Chissano administrations adapted foreign systems of government and education (i.e., Socialism, Soviet, Democracy, Portuguese, etc., to their particular context without altering the inherent theoretical basis of the systems transferred; (b the Machel and Chissano administrations, implicitly or explicitly, perceived the relationship between education and development as circular causality rather than a unidirectional linear causality, while the Salazar administration perceived it as unidirectional linear causality; and (c while the Machel and Chissano administrations focused on primary education, literacy campaigns, and education of women and girls, they differed in the reasons for such focus.

Jose Cossa

2011-03-01

396

Development of the environmental neutron detection system  

CERN Document Server

Environmental neutron detection system was proposed and developed. The main goal of this system was set to detect fast and thermal neutrons with the identical detectors setup without degraders. This system consists of a sup 1 sup 0 B doped liquid scintillator for n detection and CsI scintillators for simultaneous gamma emission from sup 1 sup 0 B doped in the liquid scintillator after the n capture reaction. The first setup was optimized for the thermal n detection, while the second setup was for the fast n detection. It was shown that the thermal n flux was obtained in the first setup by using the method of the gamma coincidence method with the help of the Monte Carlo calculation. The second setup was designed to improve the detection efficiency for the fast n, and was shown qualitatively that both the pulse shape discrimination and the coincidence methods are efficient. There will be more improvements, particularly for the quantitative discussion.

Kume, K

2002-01-01

397

Development of an automated handwriting analysis system  

Directory of Open Access Journals (Sweden)

Full Text Available In the present study a method has been proposed for the behavioral prediction of a person through automated handwriting analysis. The present work identifies the psychological traits in the writing namely size, slant and pressure, baseline, number of breaks, margins, speed of writing and spacing between the words. The handwriting is analyzed through Image Processing in MATLAB. The behavioral pattern of the person is predicted from the above traits of the handwriting. The developed system identifies handwriting closely which may not be possible for a graphologist. It is real time and involves less image preprocessing. The proposed system is calibrated with manual analysis. The results obtained through the system are in good agreement to more than 80 percent of the cases with ideal manual analysis.

Vikram Kamath

2011-09-01

398

Development of the Medium Energy Linac Systems  

International Nuclear Information System (INIS)

The main purposes of the proton engineering frontier project is developing a proton linac which accelerates 20 mA proton beams up to 100 MeV and supplying 20 MeV and 100 MeV proton beams to the user groups. The project 'Development of the medium energy linac systems' is aiming to design the 100 MeV proton linac, to construct an accelerating cavity, to design a MEBT system, and to develop a energy measurement system. The 100 MeV linac consists of 20 DTL tanks which are operated by five additional klystrons. The focusing lattice is FFDD as the 20 MeV DTL. However the hollow conductors are used for coils of the quadrupole magnets. The shape of the drift tubes in the new tanks is changed to compensate the reduction of the accelerating efficiency in the high energy region. For example, the face angle of drift tubes begins at 40 degrees. The bore radius is selected as 10 mm in order to eliminate beam loss in the beam line. We can obtain the 100 MeV proton beams by using these accelerating structure. We have designed some of the tanks in detail. It covers the modification of the structure by including the stem, post-coupler, and sulg-tuner effects, the error analysis, the thermal and structure analysis, the drift tube design, the magnet design, the various ports design, the support structure design, the end-plate design, etc. Now the first DTL tank is constructed by a local company. An beam extraction system is essential after 20 MeV DTL in order to supply 20 MeV proton beams. Since there are no focusing elements in the structure, the beam should be spread out. The MEBT which consists of two 3-cell DTL tanks is designed to control the beam size in the beam extraction system by magnets in the first tank and to transversely match the beam into the next DTL by magnets in the the second tank. The longitudinal matching is done by the RF in both tanks. We have also developed an energy measurement system using the time of flight method

399

System for Anomaly and Failure Detection (SAFD) system development  

Science.gov (United States)

The System for Anomaly and Failure Detection (SAFD) algorithm was developed as an improvement over the current redline system used in the Space Shuttle Main Engine Controller (SSMEC). Simulation tests and execution against previous hot fire tests demonstrated that the SAFD algorithm can detect engine failures as much as tens of seconds before the redline system recognized the failure. Although the current algorithm only operates during steady state conditions (engine not throttling), work is underway to expand the algorithm to work during transient conditions. This task assignment originally specified developing a platform for executing the algorithm during hot fire tests at Technology Test Bed (TTB) and installing the SAFD algorithm on that platform. Two units were built and installed in the Hardware Simulation Lab and at the TTB in December 1991. Since that time, the task primarily entailed improvement and maintenance of the systems, additional testing to prove the feasibility of the algorithm, and support of hot fire testing. This document addresses the work done since the last report of June 1992. The work on the System for Anomaly and Failure Detection during this period included improving the platform and the algorithm, testing the algorithm against previous test data and in the Hardware Simulation Lab, installing other algorithms on the system, providing support for operations at the Technology Test Bed, and providing routine maintenance.

Oreilly, D.

1993-09-01

400

Development of Vertical Cable Seismic System (2)  

Science.gov (United States)

The vertical cable seismic is one of the reflection seismic methods. It uses hydrophone arrays vertically moored from the seafloor to record acoustic waves generated by surface, deep-towed or ocean bottom sources. Analyzing the reflections from the sub-seabed, we could look into the subsurface structure. This type of survey is generally called VCS (Vertical Cable Seismic). Because VCS is an efficient high-resolution 3D seismic survey method for a spatially-bounded area, we proposed the method for the hydrothermal deposit survey tool development program that the Ministry of Education, Culture, Sports, Science and Technology (MEXT) started in 2009. We are now developing a VCS system, including not only data acquisition hardware but data processing and analysis technique. Our first experiment of VCS surveys has been carried out in Lake Biwa, JAPAN in November 2009 for a feasibility study. Prestack depth migration is applied to the 3D VCS data to obtain a high quality 3D depth volume. Based on the results from the feasibility study, we have developed two autonomous recording VCS systems. After we carried out a trial experiment in the actual ocean at a water depth of about 400m and we carried out the second VCS survey at Iheya Knoll with a deep-towed source. In this survey, we could establish the procedures for the deployment/recovery of the system and could examine the locations and the fluctuations of the vertical cables at a water depth of around 1000m. The acquired VCS data clearly shows the reflections from the sub-seafloor. Through the experiment, we could confirm that our VCS system works well even in the severe circumstances around the locations of seafloor hydrothermal deposits. We have carried out two field surveys in 2011. One is a 3D survey with a boomer for a high-resolution surface source and the other one for an actual field survey in the Izena Cauldron an active hydrothermal area in the Okinawa Trough. Through these surveys, we have confirmed that the uncertainty in the locations of the source and of the hydrophones in water could lower the quality of subsurface image. It is, therefore, strongly necessary to develop a total survey system that assures an accurate positioning and a deployment techniques. In case of shooting on sea surface, GPS navigation system are available, but in case of deep-towed source or ocean bottom source, the accuracy of shot position with SSBL/USBL is not sufficient for the very high-resolution imaging as requested for the SMS survey. We will incorporate the accurate LBL navigation systems with VCs. The LBL navigation system has been developed by IIS of the University of Tokyo. The error is estimated less than 10cm at the water depth of 3000m. Another approach is that the shot points can be calculated using the first break of the VCS after the VCS locations are estimated by slant-ranging from the sea surface. Our VCS system has been designed as a survey tool for hydrothermal deposit, but it will be also applicable for deep water site surveys or geohazard assessment such as active faults.

Asakawa, E.; Murakami, F.; Tsukahara, H.; Ishikawa, K.

2012-12-01

401

Lunar Surface Systems Supportability Technology Development Roadmap  

Science.gov (United States)

The Lunar Surface Systems Supportability Technology Development Roadmap is a guide for developing the technologies needed to enable the supportable, sustainable, and affordable exploration of the Moon and other destinations beyond Earth. Supportability is defined in terms of space maintenance, repair, and related logistics. This report considers the supportability lessons learned from NASA and the Department of Defense. Lunar Outpost supportability needs are summarized, and a supportability technology strategy is established to make the transition from high logistics dependence to logistics independence. This strategy will enable flight crews to act effectively to respond to problems and exploit opportunities in an environment of extreme resource scarcity and isolation. The supportability roadmap defines the general technology selection criteria. Technologies are organized into three categories: diagnostics, test, and verification; maintenance and repair; and scavenge and recycle. Furthermore, "embedded technologies" and "process technologies" are used to designate distinct technology types with different development cycles. The roadmap examines the current technology readiness level and lays out a four-phase incremental development schedule with selection decision gates. The supportability technology roadmap is intended to develop technologies with the widest possible capability and utility while minimizing the impact on crew time and training and remaining within the time and cost constraints of the program.

Oeftering, Richard C.; Struk, Peter M.; Green, Jennifer L.; Chau, Savio N.; Curell, Philip C.; Dempsey, Cathy A.; Patterson, Linda P.; Robbins, William; Steele, Michael A.; DAnnunzio, Anthony; Meseroll, Robert; Quiter, John; Shannon, Russell; Easton, John W.; Madaras, Eric I.; BrownTaminger, Karen M.; Tabera, John T.; Tellado, Joseph; Williams, Marth K.; Zeitlin, Nancy P.

2011-01-01

402

Overview of superconducting magnet power supply system for the KSTAR 1ST plasma experiment  

International Nuclear Information System (INIS)

The KSTAR Magnet Power Supply (MPS) was dedicated to the SC coil commissioning and 1st plasma experiment as a part of the system commissioning. Although many efforts to develop large-current power supplies that are useful for high power electronic devices have been made in various application fields, such as for large metal-plating devices, there were clear discrepancies between conventional power supply technologies and that for the SC coils due to the special SC coil load conditions. Therefore, most of the power supply technologies for the SC coils were a challenge in the domestic research area due to their limited application. However, the MPS commissioning result showed that all of the hardware and controlling software operated well, and this result finally led to the success of SC coil commissioning and the KSTAR 1st plasma experiment. This paper will describe key features of KSTAR MPS for the 1st plasma experiment, and will also report the commissioning results of the magnet power supplies

403

Information systems for engineering sustainable development  

Energy Technology Data Exchange (ETDEWEB)

The ability of a country to follow sustainable development paths is determined to a large extent by the capacity or capabilities of its people and its institutions. Specifically, capacity-building in the UNCED terminology encompasses the country`s human, scientific, technological, organizational, institutional, and resource capabilities. A fundamental goal of capacity-building is to enhance the ability to pose, evaluate and address crucial questions related to policy choices and methods of implementation among development options. As a result the United Nations Conference on Environment and Development (UNCED) Agenda 21 planning process has identified the need for better methods by which information can be transferred between industrialized nations and developing nations. The reasons for better methods of information transfer include facilitating decisions related to sustainable development and building the capacity of developing nations to better plan their future in both an economical and environmentally sound manner. This paper is a discussion on mechanisms for providing information and technologies available for presenting the information to a variety of cultures and levels of technical literacy. Consideration is given to access to information technology as well as to the cost to the user. One concept discussed includes an ``Engineering Partnership`` which brings together the talents and resources of private consulting engineers, corporations, non-profit professional organizations, government agencies and funding institution which work in partnership with each other and associates in developing countries. Concepts which are related to information technologies include a hypertext based, user configurable cultural translator and information navigator and the use of multi-media technologies to educate engineers about the concepts of sustainability, and the adaptation of the concept of metabolism to creating industrial systems.

Leonard, R.S.

1992-02-27

404

Information systems for engineering sustainable development  

Energy Technology Data Exchange (ETDEWEB)

The ability of a country to follow sustainable development paths is determined to a large extent by the capacity or capabilities of its people and its institutions. Specifically, capacity-building in the UNCED terminology encompasses the country's human, scientific, technological, organizational, institutional, and resource capabilities. A fundamental goal of capacity-building is to enhance the ability to pose, evaluate and address crucial questions related to policy choices and methods of implementation among development options. As a result the United Nations Conference on Environment and Development (UNCED) Agenda 21 planning process has identified the need for better methods by which information can be transferred between industrialized nations and developing nations. The reasons for better methods of information transfer include facilitating decisions related to sustainable development and building the capacity of developing nations to better plan their future in both an economical and environmentally sound manner. This paper is a discussion on mechanisms for providing information and technologies available for presenting the information to a variety of cultures and levels of technical literacy. Consideration is given to access to information technology as well as to the cost to the user. One concept discussed includes an Engineering Partnership'' which brings together the talents and resources of private consulting engineers, corporations, non-profit professional organizations, government agencies and funding institution which work in partnership with each other and associates in developing countries. Concepts which are related to information technologies include a hypertext based, user configurable cultural translator and information navigator and the use of multi-media technologies to educate engineers about the concepts of sustainability, and the adaptation of the concept of metabolism to creating industrial systems.

Leonard, R.S.

1992-02-27

405

Development of superconducting ship propulsion system  

International Nuclear Information System (INIS)

When we plan displacement-type monohull high speed vessels, it is difficult to get the hull form with the wave-making resistance minimum, because the stern shape is restricted by arrangement of propulsive machines and shafts. A small-sized and light-weight propulsive machines will reduce the limit to full form design. Superconducting technology will have capability of realizing the small-sized and light-weight propulsion motor. The superconducting electric propulsion system which is composed of superconducting propulsion motors and generators, seems to be an ideal propulsion system for future vehicles. We have constructed a 480 kW superconducting DC homopolar laboratory test motor for developing this propulsion system. The characteristic of this motor is that it has a superconducting field winding and a segmented armature drum. The superconducting field winding which operates in the persistent current mode, is cooled by a condensation heat exchanger and helium refigerating system built into the cryostat of the superconducting field winding. The operating parameters of this motor agreed well with the design parameters. Using the design concepts of this motor, we have conceptually designed a 150,000-200,000 PS superconducting electric propulsive system for a displacement-type monohull high speed ship. (author)

406

Kinetochore localized Mad2 and Cdc20 is itself insufficient for triggering the mitotic checkpoint when Mps1 is low in Drosophila melanogaster neuroblasts.  

Science.gov (United States)

The relationships between the kinetochore and checkpoint control remain unresolved. Here, we report the characterization of the in vivo behavior of Cdc20 and Mad2 and the relevant spindle assembly checkpoint (SAC) functions in the neuroblasts of a Drosophila Mps1 weak allele (ald (B4-2) ). ald (B4-2) third instar larvae brain samples contain only around 16% endogenous Mps1 protein, and the SAC function is abolished. However, this does not lead to rapid anaphase onset and mitotic exit, in contrast to the loss of Mad2 alone in a mad2 (EY) mutant. The level of GFP-Cdc20 recruitment to the kinetochore is unaffected in ald (B4-2) neuroblasts, while the level of GFP-Mad2 is reduced to just about 20%. Cdc20 and Mad2 display only monophasic exponential kinetics at the kinetochores. The ald (B4-2) heterozygotes expressed approximately 65% of normal Mps1 protein levels, and this is enough to restore the SAC function. The kinetochore recruitment of GFP-Mad2 in response to SAC activation increases by around 80% in heterozygotes, compared with just about 20% in ald (B4-2) mutant. This suggests a correlation between Mps1 levels and Mad2 kinetochore localization and perhaps the existence of a threshold level at which Mps1 is fully functional. The failure to arrest the mitotic progression in ald (B4-2) neuroblasts in response to colchicine treatment suggests that when Mps1 levels are low, approximately 20% of normal GFP-Mad2, alongside normal levels of GFP-Cdc20 kinetochore recruitments, is insufficient for triggering SAC signal propagation. PMID:23187806

Herriott, Ashleigh; Sweeney, Michele; Whitaker, Michael; Taggart, Michael; Huang, Jun-Yong

2012-12-15

407

Development of deep electrical resistivity measurement system  

Energy Technology Data Exchange (ETDEWEB)

A New deep electrical resistivity exploration system was developed. This system mainly consists of a stand-alone Tx(transmitter) module, of which the excitation current into the earth has been increased very much using a portable AC generator instead of batteries, a digital stacking Rx(receiver), and a pair of synchronization clock modules to achieve the initial synchronization between Tx and Rx. The waveform of the excitation current into the earth at transmitter side is double bipolar, and the power is 1000V/1A or 800V/5A with a portable AC generator. At the receiver part controlled through a notebook PC's serial port and measuring the potential difference between two poles, the operator can observe the exact waveform and averaged value 24 bits A/D converted with gain 1, 10, 100, and 300. The small portable synchronization clocks, operated by 12V/2A sealed battery, provides the precise basic measurement cycles and initial triggering. The system was field-tested in the western part of Cheju-Island with dipole spacing a=300m to n=10, and stations=30, by the array of which the exploration depth has been increased to about 1,200 m. By the developed portable system we could conduct very easy and fast field work and acquire very satisfactory data. The inversion of measured data gave us the information about the sub-surface resistivity structure to about 1,200 m depth along a 8 km survey profile. Further study will be focused on high speed multichannel data acquisition system for SIP(Spectral Induced Polarization) CR (Complex Resistivity) and CSAMT (Controlled Source Audio-Frequency Magnetotelluric). (author). 23 refs., 26 figs.

Jung, Hyun Key; Lim, Mu Taek; Kim, Yoo Sung; Jumg, Ho Joon; Choi, Jong Ho; Sung, Nak Hoon; Park In Hwa [Korea Institute of Geology Mining and Materials, Taejon (Korea)

1998-12-01

408

The Mediterranean Forecasting System: recent developments  

Science.gov (United States)

Recent developments of the Mediterranean Monitoring and Forecasting Centre of the EU-Copernicus marine service, the Mediterranean Forecasting System (MFS), are presented. MFS provides forecast, analysis and reanalysis for the physical and biogeochemical parameters of the Mediterranean Sea. The different components of the system are continuously updated in order to provide to the users the best available product. This work is focus on the physical component of the system. The physical core of MFS is composed by an ocean general circulation model (NEMO) coupled with a spectral wave model (Wave Watch-III). The NEMO model provides to WW-III surface currents and SST fields, while WW-III returns back to NEMO the neutral component of the surface drag coefficient. Satellite Sea Level Anomaly observations and in-situ T & S vertical profiles are assimilated into this system using a variational assimilation scheme based on 3DVAR (Dobricic, 2008) . Sensitive experiments have been performed in order to assess the impact of the assimilation of the latest available SLA missions, Altika and Cryosat together with the long term available mission of Jason2. The results show a significant improvement of the MFS skill due to the multi-mission along track assimilation. The primitive equations module has been recently upgraded with the introduction of the atmospheric pressure term and a new, explicit, numerical scheme has been adopted to solve the barotropic component of the equations of motion. The SLA satellite observations for data assimilation have been consequently modified in order to account for the new atmospheric pressure term introduced in the equations. This new system has been evaluated using tide gauge coastal buoys and the satellite along track data. The quality of the SSH has improved significantly while a minor impact has been observed on the other state variables (temperature, salinity and currents). Experiments with a higher resolution NWP (numerical weather prediction) forcing provided by the COSMO-MED system (provided by the Italian Meteorological Office), have been performed and a pre-operational 3-day forecast production system has been developed. The comparison between this system and the official one forced by the ECMWF NWP data will be discussed.

Tonani, Marina; Oddo, Paolo; Korres, Gerasimos; Clementi, Emanuela; Dobricic, Srdjan; Drudi, Massimiliano; Pistoia, Jenny; Guarnieri, Antonio; Romaniello, Vito; Girardi, Giacomo; Grandi, Alessandro; Bonaduce, Antonio; Pinardi, Nadia

2014-05-01

409

Development of decommissioning system engineering technology  

International Nuclear Information System (INIS)

In the decommissioning planning stage, it is important to select the optimized decommissioning process considering the cost and safety. Especially the selection of the optimized decommissioning process is necessary because it affects to improve worker's safety and decommissioning work efficiency. The decommissioning process evaluation technology can provide the optimized decommissioning process as constructing various decommissioning scenarios and it can help to prevent the potential accidents as delivering the exact work procedures to workers and to help workers to perform decommissioning work skillfully. It's necessary to measure the radioactive contamination in the highly contaminated facilities such as hot-cells or glove-boxes to be decommissioned for decommissioning planning. These facilities are very high radiation level, so it is difficult to approach. In this case the detector system is preferable to separate the sensor and electronics, which have to locate in the facility outside to avoid the electric noise and worker's radiation exposure. In this project, we developed the remote detection system for radiation measurement and signal transmission in the high radiation area. In order to minimize worker's exposure when decommissioning highly activated nuclear facilities, it is necessary to develop the remote handling tool to perform the dismantling work remotely. Especially, since cutting, measuring, and decontamination works should be performed remotely in the highly activated area, the remote handling tool for conducting these works should be developed. Therefore, the multi-purpose dismantling machine that can measuring dose, facility cutting, and remote handling for maintenance and decommissioning of highly activated facility should be needed

410

Development of the plutonium oxide vitrification system  

International Nuclear Information System (INIS)

Repository disposal of plutonium in a suitable, immobilized form is being considered as one option for the disposition of surplus weapons-usable plutonium. Accelerated development efforts were completed in 1997 on two potential immobilization forms to facilitate downselection to one form for continued development. The two forms studied were a crystalline ceramic based on Synroc technology and a lanthanide borosilicate (LaBS) glass. As part of the glass development program, melter design activities and component testing were completed to demonstrate the feasibility of using glass as an immobilization medium. A prototypical melter was designed and built in 1997. The melter vessel and drain tube were constructed of a Pt/Rh alloy. Separate induction systems were used to heat the vessel and drain tube. A Pt/Rh stirrer was incorporated into the design to facilitate homogenization of the melt. Integrated powder feeding and off-gas systems completed the overall design. Concurrent with the design efforts, testing was conducted using a plutonium surrogate LaBS composition in an existing (near-scale) melter to demonstrate the feasibility of processing the LaBS glass on a production scale. Additionally, the drain tube configuration was successfully tested using a plutonium surrogate LaBS glass

411

Kinetochore localized Mad2 and Cdc20 is itself insufficient for triggering the mitotic checkpoint when Mps1 is low in Drosophila melanogaster neuroblasts  

OpenAIRE

The relationships between the kinetochore and checkpoint control remain unresolved. Here, we report the characterization of the in vivo behavior of Cdc20 and Mad2 and the relevant spindle assembly checkpoint (SAC) functions in the neuroblasts of a Drosophila Mps1 weak allele (aldB4–2). aldB4–2 third instar larvae brain samples contain only around 16% endogenous Mps1 protein, and the SAC function is abolished. However, this does not lead to rapid anaphase onset and mitotic exit, in contras...

Herriott, Ashleigh; Sweeney, Michele; Whitaker, Michael; Taggart, Michael; Huang, Jun-yong

2012-01-01

412

Developments towards a fully automated AMS system  

Science.gov (United States)

The possibilities of computer-assisted and automated accelerator mass spectrometry (AMS) measurements were explored. The goal of these efforts is to develop fully automated procedures for "routine" measurements at the Vienna Environmental Research Accelerator (VERA), a dedicated 3-MV Pelletron tandem AMS facility. As a new tool for automatic tuning of the ion optics we developed a multi-dimensional optimization algorithm robust to noise, which was applied for 14C and 10Be. The actual isotope ratio measurements are performed in a fully automated fashion and do not require the presence of an operator. Incoming data are evaluated online and the results can be accessed via Internet. The system was used for 14C, 10Be, 26Al and 129I measurements.

Steier, P.; Puchegger, S.; Golser, R.; Kutschera, W.; Priller, A.; Rom, W.; Wallner, A.; Wild, E.

2000-03-01

413

Developing Information System on Lunar Crescent Observations  

Directory of Open Access Journals (Sweden)

Full Text Available We present a progress report on the development of information system of lunar crescent astronomical observations which will be largely accessible for public domain. This consists of calculations of the Moon’s ephemeris as well as systematic real-time lunar crescent observations. A well suited small telescope, equipped with a simple digital detector, is connected to a server to provide information on lunar crescent observations. The system has been used and worked well. The only constraint is poor weather condition. Network of small telescopes, installed at various locations in Indonesia, are currently planned to provide plethora of data. In the long term, this will be used to help to determine the astronomical visibility criteria of lunar crescent for Islamic calendar.

T. Hidayat

2010-03-01

414

Development of rationalized system treating floor drain  

International Nuclear Information System (INIS)

Radioactive liquid wastes generated at BWR plants are collected and treated as required. These days, however, generation of floor drain has deceased and HFF (Hollow Fiber Filter) has experienced a wide applicability to several kinds of liquid wastes. We should consider that the floor drain can be mixed and diluted with equipment drain and be purified by HFF. That enables some of the sumps and long priming pipes to be combined. From this point of view, we have developed a highly rationalized waste liquid system. We have evaluated the applicability of this system after an investigation into the generation and properties of floor drain and equipment drain at the latest BWR'S and an on-site test at a typical BWR. (author)

415

Development of energy and transport systems  

International Nuclear Information System (INIS)

Economic development and the advancement of technology is presented as a process of substituting old forms of satisfying human needs by new ones or, more precisely, as a sequence of such substitutions. The examples, reconstructed from historical records, describe the quantitative, technological changes in energy and transport systems. The analysis of historical replacement of old by new technologies has shown that most of these processes can be described by simple rules that are captured in the logistic substitution model, and that technological substitution, expressed in terms of market shares, follows characteristic S-shaped curves. To illustrate the properties of the approach examples are given of how new energy forms replaced their predecessors. To further explore the method similar substitution processes in transport systems are described. 21 refs, 23 figs, 1 tab

416

The development of a neurosurgical navigation system  

International Nuclear Information System (INIS)

A Computer Assisted Neurosurgical Navigation System (CANS Navigator) has been developed, which assists neurosurgeons in surgery by utilizing images from highly advanced medical imaging devices. During a surgical procedure, the positional and directional information about the surgical, tools can be confirmed by observing their location on the CT or MR images on the CRT monitor. Applying magnetic field technology to position measurement, the position sensor attached to the surgical tool can be made small and light. As a result, no interference occurs with the surgical procedure. Performed on important fine vessels and nerves, neurosurgery requires precision techniques often lasting many hours. Therefore, the surgeons bear great loads physically and psychologically. Because understanding the location of the diseased part and the various organs can be made easy, the use of this system reduces the workload on surgeons and helps effect more accurate and safer surgery. (author)

417

New developments of the GANIL control system  

International Nuclear Information System (INIS)

Since its first ion beam, the GANIL accelerator has been driven by a Control System built around a minicomputer MITRA 125 and a distributed intelligence consisting of programmable Controllers and INTEL 8080 equipped autonomous CAMAC Controllers. After a brief description of the GANIL Control System, this paper will lay emphasis on the major improvements undertaken along four main directions: a) Upgrading the Control Computer. b) Introducing more powerful local intelligence. A microprocessorized autonomous CAMAC Controller called ''DIVA 68C'' using the 68000 microprocessor embedded in a VME card has been developed. Also, the 68000 will be used in a general purpose CAMAC module, the first application of which is to replace the existing data link modules. (c) Making human-machine dialog smarter with use of color graphic terminals. d) Meeting the requirements of the coming second injector. In this purpose a fully equipped auxiliary console is being installed near the main console for operation by summer 1985

418

Development of plant construction scheduling support system  

International Nuclear Information System (INIS)

A scheduling support system through knowledge-based man-machine cooperation has been developed for nuclear power plant construction. The proposed system, named NPCS, has three characteristic functions: (1) Automatic dissolution of constraint violations using a constraint-oriented programming technique; (2) Automatic resource leveling based on a combinatorial-optimization technique using heuristic rules on task ordering; (3) Display of a scheduling chart which facilitates interactive schedule modification performed by expert engineers. A scheduling process of NPCS consists of two steps. At the first steps, an initial schedule with leveled resource is built, and at the second step, the initial schedule is improved interactively, where constraint violations are dissolved automatically. NPCS was experimentally applied to solve about 80 scheduling problems in a nuclear power plant construction and confirmed to reduce the scheduling time and to improve the quality of the schedule. (author)

419

DEVELOPMENT AND MARKET OF ERP SYSTEMS  

Directory of Open Access Journals (Sweden)

Full Text Available The business environment’s changes occurring more and more quickly and company activities’ becoming more and more complex require permanent, fast adjustments which often test human factors’ abilities for efforts and analyses. The creation and development of ERP-type systems have been and are still believed to be the solutions of such challenges ensuring certain support to process large amounts of data and information needed in companies’ decision-making processes. An ERP system helps the integration of a company’s set of information into a single platform due to the way in which it succeeds in combining business management techniques and practices with the new information technology, providing the transparency of data and the access to the necessary information.

DIANA-ELENA CODREANU

2012-11-01

420

Development of nuclear plant piping support system  

International Nuclear Information System (INIS)

Design and construction of a nuclear power plant is characterized by its voluminous work extending for a long period on account of the increasingly stringent requirements focused on productivity to keep ''just in time'' construction schedule by paying close attention to both safety and availability of the plant. The Nuclear Plant Piping Support System has been developed in order to increase productivity with the best quality and to keep down the cost. This system selects the optimum size of structures for each support and sets this data in the central engineering data base of the main frame computer. Therefore, the data can be used for various subsystems such as design analysis, material handling and the control of production. (author)

421

Development techniques of computerized maintenance Management system  

International Nuclear Information System (INIS)

Normal operation of the facility is one of the key factors in the accomplishments of research goals. As confirmed by a case study of the influence of the facility operation condition on the research results, emphasis should be put on the facility preserve management. Facilities should be maintained in solid operational condition and their malfunctions should be repaired as soon as possible. The purpose of this project is to make propositions on the development of the facility preserve management system which is to maximize the efficiency of the budget execution, manpower organization and maintenance planning,