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Sample records for system mps development

  1. Space Station Mission Planning System (MPS) development study. Volume 1: Executive summary

    Klus, W. J.

    1987-01-01

    The basic objective of the Space Station (SS) Mission Planning System (MPS) Development Study was to define a baseline Space Station mission plan and the associated hardware and software requirements for the system. A detailed definition of the Spacelab (SL) payload mission planning process and SL Mission Integration Planning System (MIPS) software was derived. A baseline concept was developed for performing SS manned base payload mission planning, and it was consistent with current Space Station design/operations concepts and philosophies. The SS MPS software requirements were defined. Also, requirements for new software include candidate programs for the application of artificial intelligence techniques to capture and make more effective use of mission planning expertise. A SS MPS Software Development Plan was developed which phases efforts for the development software to implement the SS mission planning concept.

  2. MPS II drift chamber system

    The MPS II detectors are narrow drift space chambers designed for high position resolution in a magnetic field and in a very high particle flux environment. Central to this implementation was the development of 3 multi-channel custom IC's and one multi-channel hybrid. The system is deadtimeless and requires no corrections on an anode-to-anode basis. Operational experience and relevance to ISABELLE detectors is discussed

  3. Space Station Mission Planning System (MPS) development study. Volume 2

    Klus, W. J.

    1987-01-01

    The process and existing software used for Spacelab payload mission planning were studied. A complete baseline definition of the Spacelab payload mission planning process was established, along with a definition of existing software capabilities for potential extrapolation to the Space Station. This information was used as a basis for defining system requirements to support Space Station mission planning. The Space Station mission planning concept was reviewed for the purpose of identifying areas where artificial intelligence concepts might offer substantially improved capability. Three specific artificial intelligence concepts were to be investigated for applicability: natural language interfaces; expert systems; and automatic programming. The advantages and disadvantages of interfacing an artificial intelligence language with existing FORTRAN programs or of converting totally to a new programming language were identified.

  4. MPS Data Acquisition System

    A description is given of the data acquisition system used with the multiparticle spectrometer facility at Brookhaven. Detailed information is provided on that part of the system which connects the detectors to the data handler; namely, the detector electronics, device controller, and device port optical isolator

  5. Development of J-PARC LINAC/RCS MPS sub system

    To decrease the heat damage and the radiation damage because of the beam collision extremely, MPS of J-PARC was set up. Actually, high speed (All processes from the beam loss detection to the beam complete stop around 5μ second: measurement) that almost meets a first specification and high reliability (The malfunction rate not to understand the cause is almost 0%) have been achieved though it becomes 1 and a half years by being operated in J-PARC Linac. However, it is understood that there is a demand that should be satisfied because the beam is stopped at high speed when an actual beam driving as facilities for research is considered. Then, we produced 'Logic controller', 'MWPM unit', 'Pulse pipe bend unit', and 'Trigger the checker' to satisfy these demands, and mounted it. (author)

  6. Space Station Mission Planning Study (MPS) development study. Volume 3: Software development plan

    Klus, W. L.

    1987-01-01

    A software development plan is presented for the definition, design, and implementation of the Space Station (SS) Payload Mission Planning System (MPS). This plan is an evolving document and must be updated periodically as the SS design and operations concepts as well as the SS MPS concept evolve. The major segments of this plan are as follows: an overview of the SS MPS and a description of its required capabilities including the computer programs identified as configurable items with an explanation of the place and function of each within the system; an overview of the project plan and a detailed description of each development project activity breaking each into lower level tasks where applicable; identification of the resources required and recommendations for the manner in which they should be utilized including recommended schedules and estimated manpower requirements; and a description of the practices, standards, and techniques recommended for the SS MPS Software (SW) development.

  7. MPS data-acquisition software system

    A description of the software for a FASTBUS based data-acquisition system in use at the Brookhaven National Laboratory Multiparticle Spectrometer is presented. Data reading and formating is done by the SLAC scanner processors (SSP's) resident in the FASTBUS system. A multiprocess software system on VAX computers is used to communicate with the SSP's, record the data, and monitor on-line the progress of high energy and heavy ions experiments. The structure and the performance of this system are discussed. (orig.)

  8. Mucopolysaccharidosis (MPS) Physical Symptom Score: Development, Reliability, and Validity

    Ahmed, A.; Rudser, K.; Kunin-Batson, A.; Delaney, K; Whitley, C.; Shapiro, E

    2015-01-01

    Objectives: We quantified medical signs and symptoms to construct the Physical Symptom Score (PSS) for use in research to assess somatic disease burden in mucopolysaccharidoses (MPS) to track disease and monitor treatments. We examined scoring reliability, its concurrent validity with other measures, and relationship to age in MPS type I.

  9. 3D simulation of eutectic interaction of Pb–Sn system using Moving Particle Semi-implicit (MPS) method

    Highlights: • Development of MPS eutectic model for solid–solid interaction. • Analysis of experiments dealing with eutectic behavior of Pb–Sn by MPS simulation. • The analysis has revealed the mechanism of eutectic melting due to eutectic reaction. - Abstract: The eutectic reaction phenomenon was analyzed based on the Moving Particle Semi-implicit (MPS) method. The improved MPS code was applied to three-dimensional Pb–Sn system experiments conducted at Central Research Institute of Electric Power Industry (CRIEPI). The experiments dealt with solid–solid contact materials at 225 and 205 °C. The mass diffusion process was modeled based on Fick’s second law. The criterion of eutectic reaction was modeled based on binary phase diagram. The calculated penetration rates, i.e. height reduction rates, were compared with the experimental measurements. The results obtained by the MPS simulations exhibit good agreement with the experiments carried out at 205 and 225 °C. MPS simulation predicted that Sn particle will liquefy earlier than Pb particle

  10. Neonatal Systemic AAV Induces Tolerance to CNS Gene Therapy in MPS I Dogs and Nonhuman Primates.

    Hinderer, Christian; Bell, Peter; Louboutin, Jean-Pierre; Zhu, Yanqing; Yu, Hongwei; Lin, Gloria; Choa, Ruth; Gurda, Brittney L; Bagel, Jessica; O'Donnell, Patricia; Sikora, Tracey; Ruane, Therese; Wang, Ping; Tarantal, Alice F; Casal, Margret L; Haskins, Mark E; Wilson, James M

    2015-08-01

    The potential host immune response to a nonself protein poses a fundamental challenge for gene therapies targeting recessive diseases. We demonstrate in both dogs and nonhuman primates that liver-directed gene transfer using an adeno-associated virus (AAV) vector in neonates induces a persistent state of immunological tolerance to the transgene product, substantially improving the efficacy of subsequent vector administration targeting the central nervous system (CNS). We applied this approach to a canine model of mucopolysaccharidosis type I (MPS I), a progressive neuropathic lysosomal storage disease caused by deficient activity of the enzyme α-l-iduronidase (IDUA). MPS I dogs treated systemically in the first week of life with a vector expressing canine IDUA did not develop antibodies against the enzyme and exhibited robust expression in the CNS upon intrathecal AAV delivery at 1 month of age, resulting in complete correction of brain storage lesions. Newborn rhesus monkeys treated systemically with AAV vector expressing human IDUA developed tolerance to the transgene, resulting in high cerebrospinal fluid (CSF) IDUA expression and no antibody induction after subsequent CNS gene therapy. These findings suggest that inducing tolerance to the transgene product during a critical period in immunological development can improve the efficacy and safety of gene therapy. PMID:26022732

  11. MPS Editor

    Mathews, William S.; Liu, Ning; Francis, Laurie K.; OReilly, Taifun L.; Schrock, Mitchell; Page, Dennis N.; Morris, John R.; Joswig, Joseph C.; Crockett, Thomas M.; Shams, Khawaja S.

    2011-01-01

    Previously, it was time-consuming to hand-edit data and then set up simulation runs to find the effect and impact of the input data on a spacecraft. MPS Editor provides the user the capability to create/edit/update models and sequences, and immediately try them out using what appears to the user as one piece of software. MPS Editor provides an integrated sequencing environment for users. It provides them with software that can be utilized during development as well as actual operations. In addition, it provides them with a single, consistent, user friendly interface. MPS Editor uses the Eclipse Rich Client Platform to provide an environment that can be tailored to specific missions. It provides the capability to create and edit, and includes an Activity Dictionary to build the simulation spacecraft models, build and edit sequences of commands, and model the effects of those commands on the spacecraft. MPS Editor is written in Java using the Eclipse Rich Client Platform. It is currently built with four perspectives: the Activity Dictionary Perspective, the Project Adaptation Perspective, the Sequence Building Perspective, and the Sequence Modeling Perspective. Each perspective performs a given task. If a mission doesn't require that task, the unneeded perspective is not added to that project's delivery. In the Activity Dictionary Perspective, the user builds the project-specific activities, observations, calibrations, etc. Typically, this is used during the development phases of the mission, although it can be used later to make changes and updates to the Project Activity Dictionary. In the Adaptation Perspective, the user creates the spacecraft models such as power, data store, etc. Again, this is typically used during development, but will be used to update or add models of the spacecraft. The Sequence Building Perspective allows the user to create a sequence of activities or commands that go to the spacecraft. It provides a simulation of the activities and

  12. MPS II: a tracking detector system for large high rate experiments

    The MPS II tracking detector system, developed for a variety of low cross section experiments that are only practical in a high beam rate environment, is described. It was built as a general purpose device for use in a fixed target (AGS) situation where the beam passes through all elements of the detector. The electronics is dead-timeless so that high efficiency is achieved at event rates as high as 106/sec/ch. This capability would allow these detectors to be used as close as 20 cm from a hadron-hadron collider at 1 Tev of luminosity up to 1033/cm2/sec. The detector is a multilayer-modular drift chamber using stereo projections to provide for 3-dimensional event reconstruction

  13. FEDERAL USERS CONFERENCE PRODUCT LINE TOOL SET (PLTS) MAP PRODUCTION SYSTEM (MPS) ATLAS CUSTOM GRIDS [Rev 0 was draft

    Maps, and more importantly Atlases, are assisting the user community in managing a large land area with complex issues, the most complex of which is the management of nuclear waste. The techniques and experiences discussed herein were gained while developing several atlases for use at the US Department of Energy's Hanford Site. The user community requires the ability to locate not only waste sites, but other features as well. Finding a specific waste site on a map and in the field is a difficult task at a site the size of Hanford. To find a specific waste site, the user begins by locating the item or object in an index, then locating the feature on the corresponding map within an atlas. Locating features requires a method for indexing them. The location index and how to place it on a map or atlas is the central theme presented in this article. The user requirements for atlases forced the design team to develop new and innovative solutions for requirements that Product Line Tool Set (PLTS) Map Production System (MPS)-Atlas was not designed to handle. The layout of the most complex atlases includes custom reference grids, multiple data frames, multiple map series, and up to 250 maps. All of these functional requirements are at the extreme edge of the capabilities of PLTS MPS-Atlas. This document outlines the setup of an atlas using PLTS MPS-Atlas to meet these requirements

  14. Brain Targeting in MPS-IIIA.

    Sorrentino, Nicolina Cristina; Fraldi, Alessandro

    2016-06-01

    Mucopolysaccharidosis type IIIA (MPS-IIIA) is a childhood metabolic neuropathology caused by the inherited deficiency of the lysosomal enzyme sulfamidase and is characterized by the accumulation of undegraded glycosaminoglycans in the lysosomes of cells and tissues of affected patients. MPS-IIIA represents one of the most common forms of lysosomal storage disorders (LSDs) and to date there is no cure. Since neurodegeneration is the most relevant pathological feature in MPS-IIIA patients, the treatment of the central nervous system (CNS) lesions represents the goal of any effective therapy for this devastating disorder. During the last years many advances have been made in developing and testing new therapies for brain involvement in MPS-IIIA. These studies have been possible because of the availability of mouse and dog models that recapitulate the MPS-IIIA neuropathological features. Some of these approaches are based on direct CNS administration routes through which the therapeutic molecules access the CNS via the parenchyma (intracerebral injections) or via the cerebrospinal fluid (intraventricular/intrathecal injections). These approaches are highly invasive and poorly suited for clinical use. Minimally invasive approaches are based on systemic injections into the blood stream of therapeutics capable of crossing the blood-brain barrier (BBB). This review will present the background of the clinic and pathology aspects of MPS-IIIA and will describe the current MPS-IIIA preclinical and clinical studies focusing on how a systemic therapeutic strategy based on crossing the BBB has been successfully used to treat CNS pathology and behavioral abnormalities in a mouse model of MPS-IIIA. Future clinical applications of this approach to MPS-IIIA patients will be also discussed together with the possibility of using similar strategies in other LSDs with neurological involvement. PMID:27491210

  15. National MPS Society (Mucopolysaccharidoses)

    ... Palliative Care Newborn Screening MPS I Recruitment – MAYO clinic Resources Pharmaceutical Partners BioMarin Genzyme Shire Specialty Pharmacy Providers Orsini Healthcare Compassionate Use Education Library MPS ...

  16. Functional correction of neurological and somatic disorders at later stages of disease in MPS IIIA mice by systemic scAAV9-hSGSH gene delivery.

    Fu, Haiyan; Cataldi, Marcela P; Ware, Tierra A; Zaraspe, Kimberly; Meadows, Aaron S; Murrey, Darren A; McCarty, Douglas M

    2016-01-01

    The reversibility of neuropathic lysosomal storage diseases, including MPS IIIA, is a major goal in therapeutic development, due to typically late diagnoses and a large population of untreated patients. We used self-complementary adeno-associated virus (scAAV) serotype 9 vector expressing human N-sulfoglucosamine sulfohydrolase (SGSH) to test the efficacy of treatment at later stages of the disease. We treated MPS IIIA mice at 1, 2, 3, 6, and 9 months of age with an intravenous injection of scAAV9-U1a-hSGSH vector, leading to restoration of SGSH activity and reduction of glycosaminoglycans (GAG) throughout the central nervous system (CNS) and somatic tissues at a dose of 5E12 vg/kg. Treatment up to 3 months age improved learning ability in the Morris water maze at 7.5 months, and lifespan was normalized. In mice treated at 6 months age, behavioral performance was impaired at 7.5 months, but did not decline further when retested at 12 months, and lifespan was increased, but not normalized. Treatment at 9 months did not increase life-span, though the GAG storage pathology in the CNS was improved. The study suggests that there is potential for gene therapy intervention in MPS IIIA at intermediate stages of the disease, and extends the clinical relevance of our systemic scAAV9-hSGSH gene delivery approach. PMID:27331076

  17. Search for all d-MPs for all d levels in multistate two-terminal networks

    A general method for reliability evaluation of multistate network is using minimal path vectors. A minimal path (MP) vector to system state d is called a d-MP. Most reported works on generating d-MPs are for a particular d value. However, if all d-MPs for all possible integer d values are required, we need to call such methods multiple times with respect to all d values. A more efficient method is desirable to generate all d-MPs. In this paper, we develop a recursive algorithm based on breadth-first search to search for all the d-MPs for all possible d values. The relationships among d-MPs for different d levels are revealed. Each d-MP candidate can be generated by a combination of one (d-1)-MP and the vector form of one binary minimal path. Thus, we can use binary MPs as building blocks to generate 2-MP candidates, and use 2-MPs and binary MPs as building blocks to generate 3-MP candidates … and so forth. When the d-MPs with respect to the maximum d value have been found, all the d-MPs for all possible d values are obtained. A heuristic for pre-processing the MPs is proposed to improve the efficiency of the algorithm. Through computational experiments, it is found that the proposed algorithm is more efficient than existing algorithms for finding all d-MPs for all possible d values. In addition, we show that the proposed algorithm can also be used to generate a subset of d-MPs for all or some d values given a subset of MPs. The generated subset of d-MPs can be used for lower reliability bound evaluation. - Highlights: • The relationships among d-MPs for different d levels are revealed. • An efficient algorithm is developed to search for all d-MPs for all d levels. • A heuristic for pre-processing the MPs is proposed to improve the efficiency. • The computational efficiency of the algorithm is investigated. • A method to search for subsets of d-MPs is proposed for reliability bounding

  18. Functional correction of neurological and somatic disorders at later stages of disease in MPS IIIA mice by systemic scAAV9-hSGSH gene delivery

    Fu, Haiyan; Cataldi, Marcela P.; Ware, Tierra A.; Zaraspe, Kimberly; Meadows, Aaron S; Murrey, Darren A; McCarty, Douglas M

    2016-01-01

    The reversibility of neuropathic lysosomal storage diseases, including MPS IIIA, is a major goal in therapeutic development, due to typically late diagnoses and a large population of untreated patients. We used self-complementary adeno-associated virus (scAAV) serotype 9 vector expressing human N-sulfoglucosamine sulfohydrolase (SGSH) to test the efficacy of treatment at later stages of the disease. We treated MPS IIIA mice at 1, 2, 3, 6, and 9 months of age with an intravenous injection of s...

  19. MPS/CAS Partner Group on the Development of Mechanical Knowledge in China

    Zhang Baichun; Jürgen Renn

    2004-01-01

    @@ China's long and continuous cultural tradition offers scholars the special opportunity for cross-cultural studies in the long-term development of science. The Partner Group focuses on an exemplary case of such long-term development, the development of mechanical knowledge in China from antiquity to the early modern period.

  20. viStaMPS: The Application For Viewing And Manipulating StaMPS Results

    Sousa, Joaquim; Sousa, Antonio; Magalhaes, Luis; Ruiz, Antonio

    2013-12-01

    viStaMPS (visual StaMPS) is a new visual application developed to enhance the visualization, manipulation and exportation of StaMPS results. The programmed application is developed in Matlab® through the Graphical User Interface (GUI) and no coding is required for running it, which avoids any programming language knowledge for standard uses. This tool integrates fully new features together with various scripts from StaMPS, allowing the generation of the desired plots/maps in a user-friendly interface. It is done by simply clicking some buttons or changing some parameters located in visual panels, instead of input commands in a prompt. Moreover, since it is written in Matlab, it gives the users the opportunity to access the data very easily and make their own modifications. Being a research tool, viStaMPS is continually under development and will count on the dynamism of its users to improve and/or add new features.

  1. Replacement of heavy components of the Main Primary System (MPS). Recent innovations made by Framatome ANP

    condition of the various penetrations (lateral or from above, for instrumentation, unloading, spraying, etc.): - Complete replacement of the component (including dissimilar metal welds, thermal sleeves and even a section of the surge line if necessary); - Bottom replacement; - Replacement of faulty penetrations only. Along with the regular replacement of molded Main Primary System elbows (SGR operations), the following actions have also been carried out: - Replacement of a half crossover leg (SGR-GR4, 2000); - Replacement of a cold leg section (RCLS) with a chemical and volume control system (CVCS) nozzle (SGR-FH1, 2002). In the future we predict work will be carried out on the pressurizer surge line (potentially carried out as part of a pressurizer changeover or as a stand-alone operation). This presentation will focus on the major innovations developed by Framatome ANP, aided by its international customers in order to carry out these primary component replacement operations as well and as quickly as possible. These innovations concern the following domains: - Hoisting and handling; - Metrology and topo-metry; - Machining and welding; - Automated operations in piping; - Operation management. In conclusion one stresses that to increase the lifetime of their nuclear plants, optimize outages and sometimes increase thermal and electrical power it is necessary to optimize the replacement of heavy primary components. To meet the operator needs, suppliers must in turn enhance their capacity and skills in terms of: - Providing near-turnkey services (supplies and work); - Orchestrating these operations (i.e. by performing the duties of an engineering department); - Providing services in a range of fields, from concrete to instrumentation and control, and even performance testing; - Being technically innovative in all of these areas. Since the 1990's, with the assistance of its worldwide customer base, Framatome ANP has been carrying out this approach thanks to its experience as a

  2. Molten uranium eutectic interaction on iron-alloy by MPS method

    Mustari, Asril Pramutadi Andi, E-mail: pramutadi@aoni.waseda.jp; Oka, Yoshiaki

    2014-10-15

    Highlights: • Development of MPS development on eutectic model. • Binary phase diagram of Fe–U system development by THERMOCALC with NUCL10 dataset. • Eutectic behavior of TREAT experiment analysis by MPS simulation. - Abstract: Development of moving particle semi-implicit (MPS) method for predicting the eutectic reaction during severe accident, especially at the lower head, in nuclear power plants is important. In this study, solid–liquid system of eutectic interaction was developed. Mass diffusion theory was used for mass transfer between particles. Binary phase diagram was used for developing criteria of transforming into liquid/eutectic particle. THERMOCALC with NUCL10 dataset was utilized to obtain binary phase diagram. Based on the developed MPS model, the TREAT experiments were analyzed. For penetration rates of molten uranium into steel test section, the two-dimensional MPS simulations predicted agreeable values with the experiments for temperature above 1233 and 1187 °C for Armco iron and SS304, respectively. As for SS430, MPS simulation predicted agreeable result at 1244 °C.

  3. Molten uranium eutectic interaction on iron-alloy by MPS method

    Highlights: • Development of MPS development on eutectic model. • Binary phase diagram of Fe–U system development by THERMOCALC with NUCL10 dataset. • Eutectic behavior of TREAT experiment analysis by MPS simulation. - Abstract: Development of moving particle semi-implicit (MPS) method for predicting the eutectic reaction during severe accident, especially at the lower head, in nuclear power plants is important. In this study, solid–liquid system of eutectic interaction was developed. Mass diffusion theory was used for mass transfer between particles. Binary phase diagram was used for developing criteria of transforming into liquid/eutectic particle. THERMOCALC with NUCL10 dataset was utilized to obtain binary phase diagram. Based on the developed MPS model, the TREAT experiments were analyzed. For penetration rates of molten uranium into steel test section, the two-dimensional MPS simulations predicted agreeable values with the experiments for temperature above 1233 and 1187 °C for Armco iron and SS304, respectively. As for SS430, MPS simulation predicted agreeable result at 1244 °C

  4. An overview of Korean patients with mucopolysaccharidosis and collaboration through the Asia Pacific MPS Network

    Cho, Sung Yoon; Sohn, Young Bae; Jin, Dong-Kyu

    2014-01-01

    Summary Mucopolysaccharidosis (MPS) is a constellation of disorders characterized by the accumulation of mucopolysaccharides in tissues and organs. This accumulation results in the deterioration and degeneration of multiple organs. This paper describes the general distribution of types of MPS in patients, their clinical characteristics and genotypes, the development of animal studies and preclinical studies, enzyme replacement therapy in South Korea, and the development of idursulfase beta and clinical trials on idursulfase beta in South Korea. In addition, this paper discusses academic collaboration among specialists in MPS care in the Asia-Pacific region, which includes Japan, Taiwan, Malaysia, and South Korea, through an organization called the Asia-Pacific MPS Network (APMN). The Asia-Pacific MPS Registry, an electronic remote data entry system, has been developed by key doctors in the APMN. Rare diseases require international cooperation and collaboration to elucidate their mechanisms and carry out clinical trials; therefore, an organization such as the APMN is required. Furthermore, international collaboration among Asian countries and countries around the world will be of utmost importance in the future. PMID:25364648

  5. Space Shuttle Program (SSP) Orbiter Main Propulsion System (MPS) Gaseous Hydrogen (GH2) Flow Control Valve (FCV) Poppet Eddy Current (EC) Inspection Probability of Detection (POD) Study. Volume 2; Appendices

    Piascik, Robert S.; Prosser, William H.

    2011-01-01

    The Director of the NASA Engineering and Safety Center (NESC), requested an independent assessment of the anomalous gaseous hydrogen (GH2) flow incident on the Space Shuttle Program (SSP) Orbiter Vehicle (OV)-105 during the Space Transportation System (STS)-126 mission. The main propulsion system (MPS) engine #2 GH2 flow control valve (FCV) LV-57 transition from low towards high flow position without being commanded. Post-flight examination revealed that the FCV LV-57 poppet had experienced a fatigue failure that liberated a section of the poppet flange. The NESC assessment provided a peer review of the computational fluid dynamics (CFD), stress analysis, and impact testing. A probability of detection (POD) study was requested by the SSP Orbiter Project for the eddy current (EC) nondestructive evaluation (NDE) techniques that were developed to inspect the flight FCV poppets. This report contains the Appendices to the main report.

  6. Space Shuttle Program (SSP) Orbiter Main Propulsion System (MPS) Gaseous Hydrogen (GH2) Flow Control Valve (FCV) Poppet Eddy Current (EC) Inspection Probability of Detection (POD) Study. Volume 1

    Piascik, Robert S.; Prosser, William H.

    2011-01-01

    The Director of the NASA Engineering and Safety Center (NESC), requested an independent assessment of the anomalous gaseous hydrogen (GH2) flow incident on the Space Shuttle Program (SSP) Orbiter Vehicle (OV)-105 during the Space Transportation System (STS)-126 mission. The main propulsion system (MPS) engine #2 GH2 flow control valve (FCV) LV-57 transition from low towards high flow position without being commanded. Post-flight examination revealed that the FCV LV-57 poppet had experienced a fatigue failure that liberated a section of the poppet flange. The NESC assessment provided a peer review of the computational fluid dynamics (CFD), stress analysis, and impact testing. A probability of detection (POD) study was requested by the SSP Orbiter Project for the eddy current (EC) nondestructive evaluation (NDE) techniques that were developed to inspect the flight FCV poppets. This report contains the findings and recommendations from the NESC assessment.

  7. Development of a fluorometric microtiter plate-based enzyme assay for arylsulfatase B (MPS VI using dried blood spots

    Anirudh J. Ullal

    2014-01-01

    Full Text Available Mucopolysaccharidosis type VI or Maroteaux–Lamy syndrome is an autosomal recessive lysosomal storage disorder caused by deficiency of arylsulfatase B (ARS-B enzyme activity. It results in mild to severe multi-organ system failure from accumulation of undigested glycosaminoglycans (GAGs; dermatan sulfate and chondroitin-4-sulfate. We have developed a single-step enzyme assay using a fluorescent substrate and dried blood spots to measure ARS-B activity to identify disease patients. This assay is robust, reproducible, specific and convenient to perform.

  8. OLiMPS. OpenFlow Link-layer MultiPath Switching

    Newman, Harvey B. [California Institute of Technology, Pasadena, CA (United States); Barczyk, Artur [California Institute of Technology, Pasadena, CA (United States); Bredel, Michael [California Institute of Technology, Pasadena, CA (United States)

    2014-11-17

    The OLiMPS project’s goal was the development of an OpenFlow controller application allowing load balancing over multiple switched paths across a complex network topology. The second goal was to integrate the controller with Dynamic Circuit Network systems such as ESnet’s OSCARS. Both goals were achieved successfully, as laid out in this report.

  9. MPS beam control software architecture

    The new Machine Protection System (MPS) now being tested at SLAC has a beam control subsystem resident in processors located close to the beam monitoring devices within the machine. There are two types of beam control micros: Algorithm Processors (AP's) which collect and evaluate data from monitoring devices, and a Supervisor (SUPE) which collects and evaluates data from all the AP's. The SUPE also receives the global machine beamcode indicating beam presence, and passes it on to the AP's. The SUPE receives the beamcode pattern from the Master Pattern Generator (MPG) via a shared-memory communication link. MIL-1553 serial communication is used between the SUPE and the AP's, and between the AP's and the monitoring devices. Multitasking software is used to allow high priority handling of data evaluation and low priority handling of host/user interfacing and event reporting. Pipelining of data between acquisition and evaluation and reporting is used to accommodate the processing capacity, while still supporting full processing at the 36OHz broadcast rate of the beamcode pattern

  10. MPS beam control software architecture

    The new Machine Protection System (MPS) now being tested at SLAC has a beam control subsystem resident in processors located close to the beam monitoring devices within the machine. There are two types of beam control micros: Algorithm Processors (AP's) which collect and evaluate data from monitoring devices, and a Supervisor (SUPE) which collects and evaluates data from all the AP's. The SUPE also receives the global machine beamcode indicating beam presence, and passes it on to the AP's. The SUPE receives the beamcode pattern from the Master Pattern Generator (MPG) via a shared-memory communication link. MIL-1553 serial communication is used between the SUPE and the AP's, and between the AP's and the monitoring devices. Multitasking software is used to allow high priority handling of data evaluation and low priority handling of host/user interfacing and event reporting. Pipelining of data between acquisition and evaluation and reporting is used to accomodate the processing capacity, while still supporting full processing at the 360Hz broadcast rate of the beamcode pattern

  11. Mps1 kinase regulates tumor cell viability via its novel role in mitochondria.

    Zhang, X; Ling, Y; Guo, Y; Bai, Y; Shi, X; Gong, F; Tan, P; Zhang, Y; Wei, C; He, X; Ramirez, A; Liu, X; Cao, C; Zhong, H; Xu, Q; Ma, R Z

    2016-01-01

    Targeting mitotic kinase monopolar spindle 1 (Mps1) for tumor therapy has been investigated for many years. Although it was suggested that Mps1 regulates cell viability through its role in spindle assembly checkpoint (SAC), the underlying mechanism remains less defined. In an endeavor to reveal the role of high levels of mitotic kinase Mps1 in the development of colon cancer, we unexpectedly found the amount of Mps1 required for cell survival far exceeds that of maintaining SAC in aneuploid cell lines. This suggests that other functions of Mps1 besides SAC are also employed to maintain cell viability. Mps1 regulates cell viability independent of its role in cytokinesis as the genetic depletion of Mps1 spanning from metaphase to cytokinesis affects neither cytokinesis nor cell viability. Furthermore, we developed a single-cycle inhibition strategy that allows disruption of Mps1 function only in mitosis. Using this strategy, we found the functions of Mps1 in mitosis are vital for cell viability as short-term treatment of mitotic colon cancer cell lines with Mps1 inhibitors is sufficient to cause cell death. Interestingly, Mps1 inhibitors synergize with microtubule depolymerizing drug in promoting polyploidization but not in tumor cell growth inhibition. Finally, we found that Mps1 can be recruited to mitochondria by binding to voltage-dependent anion channel 1 (VDAC1) via its C-terminal fragment. This interaction is essential for cell viability as Mps1 mutant defective for interaction fails to main cell viability, causing the release of cytochrome c. Meanwhile, deprivation of VDAC1 can make tumor cells refractory to loss of Mps1-induced cell death. Collectively, we conclude that inhibition of the novel mitochondrial function Mps1 is sufficient to kill tumor cells. PMID:27383047

  12. Some modifications of MPS method for incompressible free surface flow

    Sun, Zhe; Djidjeli, K.; Xing, J. T.; Javed, A.

    2014-01-01

    As a Lagrangian mesh-free method, the Moving Particle Semi-implicit (MPS)[1] method is very suitable for simulating violent flows, such as breaking waves on free surface. However, despite its wide range of applicability, the original MPS algorithm suffers from some inherent difficulties in obtaining an accurate fluid pressure in both spatial and time domain. Different modifications to improve the method have been proposed [2-5] in the literature. In this paper, the authors developed a particl...

  13. Local Government Finance in Ghana: Disbursement and Utilisation of the MPs share of the District Assemblies Common Fund

    Nana Nimo Appiah-Agyekum

    2013-05-01

    Full Text Available The establishment of the District Assembly Common Fund (DACF in 1993 and concomitant percentage set aside for Members of Parliament (MPs in 2004 aims to support local governments and legislators in pro-poor development activities in their communities and constituencies. In spite of the importance of the MPs’ share of the District Assemblies Common Fund (MPsCF in financing local level development in Ghana, very little is known about monitoring systems and procedures on the disbursement and utilization of the funds. The study therefore assessed qualitative data derived from interviews with officials from selected Local Government Authorities (LGAs as well as other key stakeholders in the disbursement and utilization of the fund. The study findings point to the absence of legislative instrument on the management of the MPsCF. Further, monitoring of the fund was a responsibility shared by the LGAs and other external stakeholders. Finally, the effectiveness of monitoring the disbursement and utilization of the MPsCF was strongly influenced by the relationship between the Chief Executive of the Local Government Authority (LGCE and MPs in the local government area.

  14. Health-Related Quality of Life in Patients with MPS II.

    Needham, Mary; Packman, Wendy; Quinn, Natasha; Rappoport, Maxwell; Aoki, Christa; Bostrom, Alan; Cordova, Matthew; Macias, Sandra; Morgan, Cynthia; Packman, Seymour

    2015-08-01

    Mucopolysaccharidosis type II (MPS II), also known as Hunter syndrome, is a chronic and progressive X-linked lysosomal disease that mainly affects males. The National MPS Society (2013) reports that MPS II affects 1 in 100,000 to 1 in 150,000 males worldwide. Two distinct forms of the disease are based on age of onset and clinical course: attenuated and severe. MPS II affects many organ systems including the nervous, cardiovascular, gastrointestinal and respiratory systems. Clinical manifestations can include progressive hearing loss, mental impairment, and enlarged liver and spleen. This study focuses on the health-related quality of life of individuals (HRQOL) with MPS II as measured by the parent and self-report versions of the Pediatric Quality of Life Inventory (PedsQL™). Both parents of patients with MPS II as well as patients themselves reported lower scores on all domains of the PedsQL™ (physical, emotional, social and school functioning) indicating that children with MPS II have an overall lower HRQOL when compared to a healthy sample. When compared with patients with other chronic illnesses (cancer, MSUD, galactosemia,), the MPS II sample had significantly lower scores on a number of PedsQL™ scales, suggesting an overall lower HRQOL. No significant relationships were found using scores from parent or self report PedsQL™ measures and length of time on ERT. PMID:25395377

  15. Efficient MPS algorithm for periodic boundary conditions and applications

    Weyrauch, Michael; Rakov, Mykhailo V.

    2013-01-01

    We present an implementation of an efficient algorithm for the calculation of the spectrum of one-dimensional quantum systems with periodic boundary conditions. This algorithm is based on a matrix product representation for quantum states (MPS), and a similar representation for Hamiltonians and other operators (MPO). It is significantly more efficient for systems of about 100 sites and more than for small quantum systems. We apply the formalism to calculate the ground state and first excited ...

  16. Parliament on its knees: MPs' expenses and the crisis of transparency at Westminster

    Kelso, Alexandra

    2009-01-01

    In May 2009, revelations made in The Daily Telegraph about the way that MPs had used and abused the House of Commons expenses and allowances regime threw the British political system into turmoil, forced the resignation of the Speaker of the Commons along with a number of implicated MPs, and ignited talk about a crisis in parliamentary democracy and a collapse of public trust in politics. This article explores the events that led to this situation, from the structure of MPs pay and allowance ...

  17. Genetic selection for resistance to mycoplasmal pneumonia of swine (MPS) in the Landrace line influences the expression of soluble factors in blood after MPS vaccine sensitization.

    Shimazu, Tomoyuki; Borjigin, Liushiqi; Katayama, Yuki; Li, Meihua; Satoh, Takumi; Watanabe, Kouichi; Kitazawa, Haruki; Roh, Sang-gun; Aso, Hisashi; Kazuo, Katoh; Suda, Yoshihito; Sakuma, Akiko; Nakajo, Mituru; Suzuki, Keiichi

    2014-04-01

    We recently developed a Landrace line that is resistant to mycoplasmal pneumonia of swine (MPS) infection by genetic selection for five generations, and we reported that the immunophenotype of this line is different from that of the non-selected line in terms of changes in peripheral blood leukocyte population after MPS vaccination. This study followed up previous findings demonstrating changes in soluble factors in blood, namely, hormones, Mycoplasma hyopneumoniae-specific immunoglobulin G (IgG), and cytokines. These two lines were injected with MPS vaccine on days -7 and 0 after blood sampling on those days, and blood samples were collected on days -14, -7, 0, 2, 7 and 14. We found changes in the levels of many hormones and cytokines in both lines. However, we found that only growth hormone (GH) and interferon (IFN)-γ levels were statistically different between these two lines. GH concentration was reduced (day 0) and IFN-γ concentration was increased (day 14) in the MPS-selected line compared with the non-selected line, despite unchanged IFN-γ messenger RNA expression in blood cells. Although detailed mechanisms underlying these phenotypes remain unsolved, these traits would be useful to improve MPS resistance in pig production and provide an insight into MPS infection. PMID:24329865

  18. Development of a fluorescence-based in vivo phagocytosis assay to measure mononuclear phagocyte system function in the rat.

    Tartaro, Karrie; VanVolkenburg, Maria; Wilkie, Dean; Coskran, Timothy M; Kreeger, John M; Kawabata, Thomas T; Casinghino, Sandra

    2015-01-01

    The mononuclear phagocyte system (MPS) which provides protection against infection is made up of phagocytic cells that engulf and digest bacteria or other foreign substances. Suppression of the MPS may lead to decreased clearance of pathogenic microbes. Drug delivery systems and immunomodulatory therapeutics that target phagocytes have a potential to inhibit MPS function. Available methods to measure inhibition of MPS function use uptake of radioactively-labeled cells or labor-intensive semi-quantitative histologic techniques. The objective of this work was to develop a non-radioactive quantitative method to measure MPS function in vivo by administering heat-killed E. coli conjugated to a pH-sensitive fluorescent dye (Bioparticles(®)). Fluorescence of the Bioparticles(®) is increased at low pH when they are in phagocytic lysosomes. The amount of Bioparticles(®) phagocytosed by MPS organs in rats was determined by measuring fluorescence intensity in livers and spleens ex vivo using an IVIS(®) Spectrum Pre-clinical In Vivo Imaging System. Phagocytosis of the particles by peripheral blood neutrophils was measured by flow cytometry. To assess method sensitivity, compounds likely to suppress the MPS [clodronate-containing liposomes, carboxylate-modified latex particles, maleic vinyl ether (MVE) polymer] were administered to rats prior to injection of the Bioparticles(®). The E. coli particles consistently co-localized with macrophage markers in the liver but not in the spleen. All of the compounds tested decreased phagocytosis in the liver, but had no consistent effects on phagocytic activity in the spleen. In addition, administration of clodronate liposomes and MVE polymer increased the percentage of peripheral blood neutrophils that phagocytosed the Bioparticles(®). In conclusion, an in vivo rat model was developed that measures phagocytosis of E. coli particles in the liver and may be used to assess the impact of test compounds on MPS function. Still, the

  19. Analysis of material handling equipment for Maritime Prepositioning Ships (MPS) instream offload

    Sumner, John D.; Kang, Keebom

    1992-01-01

    The Maritime Prepositioning Force (MPF) program enables the United States Marine Corps to globally project rapid and sustainable combat power. The instream method of offloading equipment and supplies from the Maritime Prepositioning Ships (MPS) provides the flexibility needed to respond to a broader range of contingencies dictated by the increasingly dynamic geostrategic environment. In this paper, we develop a simulation model of an MPS instream offloading operation to provide Marine Corps c...

  20. SOD1 nanozyme with reduced toxicity and MPS accumulation.

    Jiang, Yuhang; Arounleut, Phonepasong; Rheiner, Steven; Bae, Younsoo; Kabanov, Alexander V; Milligan, Carol; Manickam, Devika S

    2016-06-10

    We previously developed a "cage"-like nano-formulation (nanozyme) for copper/Zinc superoxide dismutase (SOD1) by polyion condensation with a conventional block copolymer poly(ethylene glycol)-b-poly(L-lysine) (PEG-PLL) followed by chemical cross-linking. Herein we report a new SOD1 nanozyme based on PEG-b-poly(aspartate diethyltriamine) (PEG-PAsp(DET), or PEG-DET for short) engineered for chronic dosing. This new nanozyme was spherical (Rg/Rh=0.785), and hollow (60% water composition) nanoparticles with colloidal properties similar to PLL-based nanozyme. It was better tolerated by brain microvessel endothelial/neuronal cells, and accumulated less in the liver and spleen. This formulation reduced the infarct volumes by more than 50% in a mouse model of ischemic stroke. However, it was not effective at preventing neuromuscular junction denervation in a mutant SOD1(G93A) mouse model of amyotrophic lateral sclerosis (ALS). To our knowledge, this work is the first report of using PEG-DET for protein delivery and a direct comparison between two cationic block copolymers demonstrating the effect of polymer structure in modulating the mononuclear phagocyte system (MPS) accumulation of polyion complexes. PMID:26928528

  1. AAV Gene Therapy for MPS1-associated Corneal Blindness

    Melisa Vance; Telmo Llanga; Will Bennett; Kenton Woodard; Giridhar Murlidharan; Neil Chungfat; Aravind Asokan; Brian Gilger; Joanne Kurtzberg; Jude Samulski, R.; Hirsch, Matthew L.

    2016-01-01

    Although cord blood transplantation has significantly extended the lifespan of mucopolysaccharidosis type 1 (MPS1) patients, over 95% manifest cornea clouding with about 50% progressing to blindness. As corneal transplants are met with high rejection rates in MPS1 children, there remains no treatment to prevent blindness or restore vision in MPS1 children. Since MPS1 is caused by mutations in idua, which encodes alpha-L-iduronidase, a gene addition strategy to prevent, and potentially reverse...

  2. Reservoir Modeling by Data Integration via Intermediate Spaces and Artificial Intelligence Tools in MPS Simulation Frameworks

    Conditioning stochastic simulations are very important in many geostatistical applications that call for the introduction of nonlinear and multiple-point data in reservoir modeling. Here, a new methodology is proposed for the incorporation of different data types into multiple-point statistics (MPS) simulation frameworks. Unlike the previous techniques that call for an approximate forward model (filter) for integration of secondary data into geologically constructed models, the proposed approach develops an intermediate space where all the primary and secondary data are easily mapped onto. Definition of the intermediate space, as may be achieved via application of artificial intelligence tools like neural networks and fuzzy inference systems, eliminates the need for using filters as in previous techniques. The applicability of the proposed approach in conditioning MPS simulations to static and geologic data is verified by modeling a real example of discrete fracture networks using conventional well-log data. The training patterns are well reproduced in the realizations, while the model is also consistent with the map of secondary data

  3. On the Kinematic Motion Primitives (kMPs - Theory and Application

    Federico Lorenzo Moro

    2012-10-01

    Full Text Available Human neuromotor capabilities guarantee a wide variety of motions. A full understanding of human motion can be beneficial for rehabilitation or performance enhancement purposes, or for its reproduction on artificial systems like robots. This work aims at describing the complexity of human motion in a reduced dimensionality, by means of kinematic Motion Primitives (kMPs. A set of five invariant kMPs are identified for periodic motions, and a set of two kMPs for discrete motions. It is shown how these two sets of kMPs can be combined to synthesize more complex motion as the simultaneous execution of the periodic and the discrete motions. The results reported are an evidence of the theory of Central Pattern Generators (CPG, showing its effects on the kinematics, and are related to what presented in the literature on the Motor Primitives extracted from EMG signals.Experimental tests with the COmpliant huMANoid (COMAN were performed to show that the kMPs extracted from human subjects can be used to transfer the features of human locomotion to the gait of a robot.

  4. Numerical simulation of Taylor bubble rising in liquid lead-bismuth eutectic based on MPS method

    The Taylor bubble rising in a vertical tube filled with liquid lead-bismuth eutectic was simulated based on MPS method. Several performed results including shape development, bubble rising terminal speed fitting line, and the thickness and axial velocity profile of the falling film were presented. The simulation results were compared with some experimental results from literature and reveal the corresponding laws obeyed by the terminal speed, velocity profile and film thickness. The computational results agree well with both theoretical analysis and experimental results, which demonstrates the reasonable selection of model as well as the accuracy and reliability of MPS method. (authors)

  5. Initial experience with myocardial perfusion scintigraphy (MPS) in patients awaiting lung volume reduction surgery (LVRS)

    Full text: LVRS is an effective therapeutic option for patients with end-stage chronic airway limitation (CAL). Pre-operative cardiac assessment in such patients is vital for a favourable outcome. We reviewed the role of MPS in the pre-operative cardiac risk stratification of patients undergoing LVRS. Of 37 patients who underwent LVRS, 25 patients (11M/14F; mean age 59.9 yrs) were evaluated pre-operatively with a MPS. Two had a history of ischaemic heart disease. 17 patients were given dipyridamole (IV - 0.05mg/kg), and eight patients were given dobutamine (IV). The LVEF was determined in 11/25 patients (range - 54-79%, mean 65.5%). Reversible defects were reported in two patients; one involving the antero-lateral wall, confirmed with coronary catheterisation (C/C) (100% LAD lesion) and treated successfully with angioplasty, and 1 involving the inferior wall (false positive on C/C). Two fixed defects were reported, each involving the inferior wall and consistent with a history of prior inferior wall myocardial infarction. The post-operative course was favourable in all patients who had a MPS, except in one who died from sepsis, while another developed mild biventricular failure three months post-operatively. Both these patients had a normal MPS. In those who did not have a MPS study, 2/12 patients died in the post-operative period; one from sepsis (normal C/C), and the other from biventricular failure. No other cardiac complications were documented. Although the population size was small, MPS assisted in the pre-operative cardiac risk stratification and management of patients undergoing LVRS. Copyright (2000) The Australian and New Zealand Society of Nuclear Medicine Inc

  6. Numerical simulation of MCCI experiments by MPS method. Validation against SURC-2 and SURC-4 experiments

    The molten corium-concrete interaction (MCCI) phenomenon was analyzed based on the Moving Particle Semi-implicit (MPS) method. The developed code was applied to one-dimensional SURC-2 and SURC-4 experiments, in which a mixture composed of UO2-ZrO2-Zr and Steel-Zr were used as the melt materials respectively. The phase transition of the melt and the concrete was modeled based on a phase transition model for mixture. The effect of Zr oxidation on the concrete ablation was taken into consideration by introducing the reaction heat of Zr/SiO2 obtained from the condensed phase chemical equations into the melt pool. The calculated concrete ablation rate was compared with the experimental measures and the simulation results of the CORCON code. The simulation results by MPS agreed well with the experimental measures. The experimental and MPS results both indicated that for both experiments Zr oxidation could significantly increase the ablation rate. On the other hand, crust formation and remelting was observed to occur on the interface between the melt and the concrete in the MPS simulation. During the period before crust remelted, the concrete ablation rate calculated by MPS decreased significantly. It was indicated by the MPS results that the crust formation could play an important part in MCCI since it could slow down the concrete ablation rate by preventing the melt from interacting with the concrete. Although the experiments did not clarify this observation, the proof for this phenomenon could be deduced from the decreased concrete ablation rate during the same period of interaction presented by the experimental results. (author)

  7. AAV Gene Therapy for MPS1-associated Corneal Blindness

    Vance, Melisa; Llanga, Telmo; Bennett, Will; Woodard, Kenton; Murlidharan, Giridhar; Chungfat, Neil; Asokan, Aravind; Gilger, Brian; Kurtzberg, Joanne; Samulski, R. Jude; Hirsch, Matthew L.

    2016-01-01

    Although cord blood transplantation has significantly extended the lifespan of mucopolysaccharidosis type 1 (MPS1) patients, over 95% manifest cornea clouding with about 50% progressing to blindness. As corneal transplants are met with high rejection rates in MPS1 children, there remains no treatment to prevent blindness or restore vision in MPS1 children. Since MPS1 is caused by mutations in idua, which encodes alpha-L-iduronidase, a gene addition strategy to prevent, and potentially reverse, MPS1-associated corneal blindness was investigated. Initially, a codon optimized idua cDNA expression cassette (opt-IDUA) was validated for IDUA production and function following adeno-associated virus (AAV) vector transduction of MPS1 patient fibroblasts. Then, an AAV serotype evaluation in human cornea explants identified an AAV8 and 9 chimeric capsid (8G9) as most efficient for transduction. AAV8G9-opt-IDUA administered to human corneas via intrastromal injection demonstrated widespread transduction, which included cells that naturally produce IDUA, and resulted in a >10-fold supraphysiological increase in IDUA activity. No significant apoptosis related to AAV vectors or IDUA was observed under any conditions in both human corneas and MPS1 patient fibroblasts. The collective preclinical data demonstrate safe and efficient IDUA delivery to human corneas, which may prevent and potentially reverse MPS1-associated cornea blindness. PMID:26899286

  8. AAV Gene Therapy for MPS1-associated Corneal Blindness.

    Vance, Melisa; Llanga, Telmo; Bennett, Will; Woodard, Kenton; Murlidharan, Giridhar; Chungfat, Neil; Asokan, Aravind; Gilger, Brian; Kurtzberg, Joanne; Samulski, R Jude; Hirsch, Matthew L

    2016-01-01

    Although cord blood transplantation has significantly extended the lifespan of mucopolysaccharidosis type 1 (MPS1) patients, over 95% manifest cornea clouding with about 50% progressing to blindness. As corneal transplants are met with high rejection rates in MPS1 children, there remains no treatment to prevent blindness or restore vision in MPS1 children. Since MPS1 is caused by mutations in idua, which encodes alpha-L-iduronidase, a gene addition strategy to prevent, and potentially reverse, MPS1-associated corneal blindness was investigated. Initially, a codon optimized idua cDNA expression cassette (opt-IDUA) was validated for IDUA production and function following adeno-associated virus (AAV) vector transduction of MPS1 patient fibroblasts. Then, an AAV serotype evaluation in human cornea explants identified an AAV8 and 9 chimeric capsid (8G9) as most efficient for transduction. AAV8G9-opt-IDUA administered to human corneas via intrastromal injection demonstrated widespread transduction, which included cells that naturally produce IDUA, and resulted in a >10-fold supraphysiological increase in IDUA activity. No significant apoptosis related to AAV vectors or IDUA was observed under any conditions in both human corneas and MPS1 patient fibroblasts. The collective preclinical data demonstrate safe and efficient IDUA delivery to human corneas, which may prevent and potentially reverse MPS1-associated cornea blindness. PMID:26899286

  9. Development of fast beam-stop system using RF chopper

    To avoid heat damage and radioactivation by beam loss of the J-PARC accelerator, Machine Protection System (MPS) has been developed. Actually, high responsibility and high reliability have been achieved in J-PARC. Beam-stop method in addition to a way of RFQ OFF has been requested in order to avoid damage to the RFQ. Therefore, we have been developing a fast beam-stop system by using a RF chopper. The fast beam-stop system, including beam test, is described in this paper. (author)

  10. Characterization of novel MPS1 inhibitors with preclinical anticancer activity.

    Jemaà, M; Galluzzi, L; Kepp, O; Senovilla, L; Brands, M; Boemer, U; Koppitz, M; Lienau, P; Prechtl, S; Schulze, V; Siemeister, G; Wengner, A M; Mumberg, D; Ziegelbauer, K; Abrieu, A; Castedo, M; Vitale, I; Kroemer, G

    2013-11-01

    Monopolar spindle 1 (MPS1), a mitotic kinase that is overexpressed in several human cancers, contributes to the alignment of chromosomes to the metaphase plate as well as to the execution of the spindle assembly checkpoint (SAC). Here, we report the identification and functional characterization of three novel inhibitors of MPS1 of two independent structural classes, N-(4-{2-[(2-cyanophenyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}phenyl)-2-phenylacetamide (Mps-BAY1) (a triazolopyridine), N-cyclopropyl-4-{8-[(2-methylpropyl)amino]-6-(quinolin-5-yl)imidazo[1,2-a]pyrazin-3-yl}benzamide (Mps-BAY2a) and N-cyclopropyl-4-{8-(isobutylamino)imidazo[1,2-a]pyrazin-3-yl}benzamide (Mps-BAY2b) (two imidazopyrazines). By selectively inactivating MPS1, these small inhibitors can arrest the proliferation of cancer cells, causing their polyploidization and/or their demise. Cancer cells treated with Mps-BAY1 or Mps-BAY2a manifested multiple signs of mitotic perturbation including inefficient chromosomal congression during metaphase, unscheduled SAC inactivation and severe anaphase defects. Videomicroscopic cell fate profiling of histone 2B-green fluorescent protein-expressing cells revealed the capacity of MPS1 inhibitors to subvert the correct timing of mitosis as they induce a premature anaphase entry in the context of misaligned metaphase plates. Hence, in the presence of MPS1 inhibitors, cells either divided in a bipolar (but often asymmetric) manner or entered one or more rounds of abortive mitoses, generating gross aneuploidy and polyploidy, respectively. In both cases, cells ultimately succumbed to the mitotic catastrophe-induced activation of the mitochondrial pathway of apoptosis. Of note, low doses of MPS1 inhibitors and paclitaxel (a microtubular poison) synergized at increasing the frequency of chromosome misalignments and missegregations in the context of SAC inactivation. This resulted in massive polyploidization followed by the activation of mitotic catastrophe. A

  11. Mps1 (Monopolar Spindle 1) Protein Inhibition Affects Cellular Growth and Pro-Embryogenic Masses Morphology in Embryogenic Cultures of Araucaria angustifolia (Araucariaceae)

    Douétts-Peres, Jackellinne C.; Cruz, Marco Antônio L.; Reis, Ricardo S.; Heringer, Angelo S.; de Oliveira, Eduardo A. G.; Elbl, Paula M.; Floh, Eny I. S.; Silveira, Vanildo

    2016-01-01

    Somatic embryogenesis has been shown to be an efficient tool for studying processes based on cell growth and development. The fine regulation of the cell cycle is essential for proper embryo formation during the process of somatic embryogenesis. The aims of the present work were to identify and perform a structural and functional characterization of Mps1 and to analyze the effects of the inhibition of this protein on cellular growth and pro-embryogenic mass (PEM) morphology in embryogenic cultures of A. angustifolia. A single-copy Mps1 gene named AaMps1 was retrieved from the A. angustifolia transcriptome database, and through a mass spectrometry approach, AaMps1 was identified and quantified in embryogenic cultures. The Mps1 inhibitor SP600125 (10 μM) inhibited cellular growth and changed PEMs, and these effects were accompanied by a reduction in AaMps1 protein levels in embryogenic cultures. Our work has identified the Mps1 protein in a gymnosperm species for the first time, and we have shown that inhibiting Mps1 affects cellular growth and PEM differentiation during A. angustifolia somatic embryogenesis. These data will be useful for better understanding cell cycle control during somatic embryogenesis in plants. PMID:27064899

  12. Future opportunities for hadron spectroscopy at the MPS

    Longacre, R.S.

    1988-12-07

    Before I go into detailed MPS experiments, I will give a summary of the status of lattice gauge calculations of glueball masses plus glueball and hybrid masses from the bag model, and the flux tube model. For the following discussion, I am going to assume that multi-quark states or molecules are best described in terms of the MIT bag model of Jaffe with its spectrum best defined by work done by R.L. Jaffe and F.E. Low using a method called The P-Matrix. Using this method one sees that all 4-quark states will appear as very broad continuum like effects that one would not associate with meson resonances, except for the S* and the delta which forms a very special threshold K/bar K/ bound systems. There is a possibility that the E(1420) may also be related to the J/sup PC/ = 1/sup + +/, qq/bar q//bar q/ spectrum having its width narrowed by a final state interaction.

  13. CONDENSED MATTER: ELECTRONIC STRUCTURE, ELECTRICAL, MAGNETIC, AND OPTICAL PROPERTIES: Analytical model for reverse characteristics of 4H-SiC merged PN-Schottky (MPS) diodes

    Song, Qing-Wen; Zhang, Yu-Ming; Zhang, Yi-Men; Lü, Hong-Liang; Chen, Feng-Ping; Zheng, Qing-Li

    2009-12-01

    A new analytical model for reverse characteristics of 4H-SiC merged PN-Schottky diodes (MPS or JBS) is developed. To accurately calculate the reverse characteristics of the 4H-SiC MPS diode, the relationship between the electric field at the Schottky contact and the reverse bias is analytically established by solving the cylindrical Poisson equation after the channel has pinched off. The reverse current density calculated from the Wentzel-Kramers-Brillouin (WKB) theory is verified by comparing it with the experimental result, showing that they are in good agreement with each other. Moreover, the effects of P-region spacing (S) and P-junction depth (Xj) on the characteristics of 4H-SiC MPS are analysed, and are particularly useful for optimizing the design of the high voltage MPS diodes.

  14. MPS/CAS Partner Group on Nanostructured Materials

    Lu Ke; Manfred Rühle

    2004-01-01

    @@ As one of the first Partner Groups which were initiated to foster scientific exchange and interaction between the Max Pianck Society (MPS) and the Chinese Academy of Sciences (CAS), the Partner Group led by Lu Ke was established on April 1, 1999.During the past five years, the group has received substantial support from the CAS for equipment and from the MPS for personnel and travel expenses. Extensive and productive collaborations between the research staff and students of the Partner Group with several professors (departments) in the Max Planck Institute for Metals Research (MPI-MF) have led to significant advances in synthesis,mechanical properties, melting and superheating of nanostructured metals. The research is well recognized internationally and a substantial number of publications in high quality, peer-reviewed journals (including Science and Physical Review Letters) have resulted.

  15. Microparticles: A New Perspective in Central Nervous System Disorders

    Stephanie M. Schindler

    2014-01-01

    Full Text Available Microparticles (MPs are a heterogeneous population of small cell-derived vesicles, ranging in size from 0.1 to 1 μm. They contain a variety of bioactive molecules, including proteins, biolipids, and nucleic acids, which can be transferred between cells without direct cell-to-cell contact. Consequently, MPs represent a novel form of intercellular communication, which could play a role in both physiological and pathological processes. Growing evidence indicates that circulating MPs contribute to the development of cancer, inflammation, and autoimmune and cardiovascular diseases. Most cell types of the central nervous system (CNS have also been shown to release MPs, which could be important for neurodevelopment, CNS maintenance, and pathologies. In disease, levels of certain MPs appear elevated; therefore, they may serve as biomarkers allowing for the development of new diagnostic tools for detecting the early stages of CNS pathologies. Quantification and characterization of MPs could also provide useful information for making decisions on treatment options and for monitoring success of therapies, particularly for such difficult-to-treat diseases as cerebral malaria, multiple sclerosis, and Alzheimer’s disease. Overall, studies on MPs in the CNS represent a novel area of research, which promises to expand the knowledge on the mechanisms governing some of the physiological and pathophysiological processes of the CNS.

  16. MRI morphometric characterisation of the paediatric cervical spine and spinal cord in children with MPS IVA (Morquio-Brailsford syndrome).

    Solanki, Guirish A; Lo, William B; Hendriksz, Christian J

    2013-03-01

    Nearly all children with MPS IVA develop skeletal deformities affecting the spine. At the atlanto-axial spine, odontoid hypoplasia occurs. GAG deposition around the dens, leads to peri-odontoid infiltration. Transverse/alar ligament incompetence causes instability. Atlanto-axial instability is associated with cord compression and myelopathy, leading to major morbidity and mortality. Intervention is often required. Does the presence of widened bullet shaped vertebra in platyspondily encroach on the spinal canal and cause spinal stenosis in MPS IVA? So far, there have been no standardised morphometric measurements of the paediatric MPS IVA cervical spine to evaluate whether there is pre-existing spinal stenosis predisposing to compressive myelopathy or whether this is purely an acquired process secondary to instability and compression. This study provides the first radiological quantitative analysis of the cervical spine and spinal cord in a series of affected children. MRI morphometry indicates that the MPS IVA spine is narrower at C1-2 level giving an inverted funnel shape. There is no evidence of a reduction in the Torg ratio (canal-body ratio) in the cervical spine. The spinal canal does not exceed 11 mm at any level, significantly smaller than normal historical cohorts (14 mm). The sagittal diameter and axial surface area of both spinal canal and cord are reduced. C1-2 level cord compression was evident in the canal-cord ratio but the Torg ratio was not predictive of cord compression. In MPS IVA the reduction in the space available for the cord (SAC) is multifactorial rather than due to congenital spinal stenosis. PMID:23404316

  17. Modified Projective Synchronization between Different Fractional-Order Systems Based on Open-Plus-Closed-Loop Control and Its Application in Image Encryption

    Hongjuan Liu; Zhiliang Zhu; Hai Yu; Qian Zhu

    2014-01-01

    A new general and systematic coupling scheme is developed to achieve the modified projective synchronization (MPS) of different fractional-order systems under parameter mismatch via the Open-Plus-Closed-Loop (OPCL) control. Based on the stability theorem of linear fractional-order systems, some sufficient conditions for MPS are proposed. Two groups of numerical simulations on the incommensurate fraction-order system and commensurate fraction-order system are presented to justify the theoretic...

  18. Quantitative mass spectrometry analysis reveals similar substrate consensus motif for human Mps1 kinase and Plk1.

    Zhen Dou

    Full Text Available BACKGROUND: Members of the Mps1 kinase family play an essential and evolutionarily conserved role in the spindle assembly checkpoint (SAC, a surveillance mechanism that ensures accurate chromosome segregation during mitosis. Human Mps1 (hMps1 is highly phosphorylated during mitosis and many phosphorylation sites have been identified. However, the upstream kinases responsible for these phosphorylations are not presently known. METHODOLOGY/PRINCIPAL FINDINGS: Here, we identify 29 in vivo phosphorylation sites in hMps1. While in vivo analyses indicate that Aurora B and hMps1 activity are required for mitotic hyper-phosphorylation of hMps1, in vitro kinase assays show that Cdk1, MAPK, Plk1 and hMps1 itself can directly phosphorylate hMps1. Although Aurora B poorly phosphorylates hMps1 in vitro, it positively regulates the localization of Mps1 to kinetochores in vivo. Most importantly, quantitative mass spectrometry analysis demonstrates that at least 12 sites within hMps1 can be attributed to autophosphorylation. Remarkably, these hMps1 autophosphorylation sites closely resemble the consensus motif of Plk1, demonstrating that these two mitotic kinases share a similar substrate consensus. CONCLUSIONS/SIGNIFICANCE: hMps1 kinase is regulated by Aurora B kinase and its autophosphorylation. Analysis on hMps1 autophosphorylation sites demonstrates that hMps1 has a substrate preference similar to Plk1 kinase.

  19. The relevance and potential roles of microphysiological systems in biology and medicine

    Wikswo, John P.

    2014-01-01

    Microphysiological systems (MPS), consisting of interacting organs-on-chips or tissue-engineered, 3D organ constructs that use human cells, present an opportunity to bring new tools to biology, medicine, pharmacology, physiology, and toxicology. This issue of Experimental Biology and Medicine describes the ongoing development of MPS that can serve as in vitro models for bone and cartilage, brain, gastrointestinal tract, lung, liver, microvasculature, reproductive tract, skeletal muscle, and s...

  20. Dicodon monitoring of protein synthesis (DiCoMPS) reveals levels of synthesis of a viral protein in single cells.

    Barhoom, Sima; Farrell, Ian; Shai, Ben; Dahary, Dvir; Cooperman, Barry S; Smilansky, Zeev; Elroy-Stein, Orna; Ehrlich, Marcelo

    2013-10-01

    The current report represents a further advancement of our previously reported technology termed Fluorescent transfer RNA (tRNA) for Translation Monitoring (FtTM), for monitoring of active global protein synthesis sites in single live cells. FtTM measures Förster resonance energy transfer (FRET) signals, generated when fluorescent tRNAs (fl-tRNAs), separately labeled as a FRET pair, occupy adjacent sites on the ribosome. The current technology, termed DiCodon Monitoring of Protein Synthesis (DiCoMPS), was developed for monitoring active synthesis of a specific protein. In DiCoMPS, specific fl-tRNA pair combinations are selected for transfection, based on the degree of enrichment of a dicodon sequence to which they bind in the mRNA of interest, relative to the background transcriptome of the cell in which the assay is performed. In this study, we used cells infected with the Epizootic Hemorrhagic Disease Virus 2-Ibaraki and measured, through DiCoMPS, the synthesis of the viral non-structural protein 3 (NS3), which is enriched in the AUA:AUA dicodon. fl-tRNA(Ile)UAU-generated FRET signals were specifically enhanced in infected cells, increased in the course of infection and were diminished on siRNA-mediated knockdown of NS3. Our results establish an experimental approach for the single-cell measurement of the levels of synthesis of a specific viral protein. PMID:23965304

  1. Surveys of MPs and Senators in the Parlament of the Czech Republic between 1993 and 2005

    Linek, Lukáš

    2005-01-01

    Roč. 41, č. 3 (2005), s. 487-498. ISSN 0038-0288 R&D Projects: GA MPS(CZ) 1J004/04-DP1 Keywords : parliamentary party groups * surveys of MPs * legislative behaviour Subject RIV: AO - Sociology, Demography Impact factor: 0.113, year: 2005

  2. 77 FR 43071 - MPS Customer Group v. Maine Public Service Company; Notice of Complaint

    2012-07-23

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission MPS Customer Group v. Maine Public Service Company; Notice of Complaint Take... Commission (Commission); 18 CFR 385.206, MPS Customer Group (Complainant) filed a formal complaint...

  3. Human swallowing simulation based on videofluorography images using Hamiltonian MPS method

    Kikuchi, Takahiro; Michiwaki, Yukihiro; Kamiya, Tetsu; Toyama, Yoshio; Tamai, Tasuku; Koshizuka, Seiichi

    2015-09-01

    In developed nations, swallowing disorders and aspiration pneumonia have become serious problems. We developed a method to simulate the behavior of the organs involved in swallowing to clarify the mechanisms of swallowing and aspiration. The shape model is based on anatomically realistic geometry, and the motion model utilizes forced displacements based on realistic dynamic images to reflect the mechanisms of human swallowing. The soft tissue organs are modeled as nonlinear elastic material using the Hamiltonian MPS method. This method allows for stable simulation of the complex swallowing movement. A penalty method using metaballs is employed to simulate contact between organ walls and smooth sliding along the walls. We performed four numerical simulations under different analysis conditions to represent four cases of swallowing, including a healthy volunteer and a patient with a swallowing disorder. The simulation results were compared to examine the epiglottic downfolding mechanism, which strongly influences the risk of aspiration.

  4. Assurance on the Reliability of Mobile Payment System and Its Effects on Its’ Use: An Empirical Examination

    Priyanka MEHARIA

    2012-01-01

    Mobile Payment Systems (MPS) such as Google Wallet are an emerging technology. This paper examines if mobile assurance as provided by examining the five criteria, namely security, availability, processing integrity, confidentiality and privacy (as per the Trust Framework by the American Institute of Certified Public Accountants (AICPA)) has any relationship with use of MPS. The theory used for this study is technology acceptance model (TAM). Some new measures were developed and validated. The...

  5. A new single-station wMPS measurement method with distance measurement

    Xie, Yu; Lin, Jiarui; Yang, Linghui; Guo, Yin; Zhao, Ziyue

    2015-10-01

    Multi-task and real-time measurement of relative displacement is widely needed in the present industrial field. Existing measuring methods require complex preparation and data processing, or are unable meet the requirement of automation, multi-task and real-time. The instruments used to measure absolute coordinates are inefficiency because of the measured target is relative displacement. A new single-station wMPS (Workspace Measuring Position System) measurement method combined distance measurement is presented in this paper. It learns from measuring principle of total station, measures angle based on rotating scanning laser plane measuring method, and measures distance based on optoelectronic scanning multi-angle intersection location principle, uses the angle-length resection measuring method, builds a new mathematical model to measure the relative displacement of the target. The result of experiment proves that it increases measuring efficiency and achieves multi-task and real-time measurement of relative displacement.

  6. The safety of anginine in patients undergoing myocardial perfusion scintigraphy (MPS)- a nurses' perspective

    Full text: Anginine-augmented MPS improves detection rate of myocardial viability and reversible ischaemia. However, anginine can cause significant hypotension. The aims of this study were to determine i) safety of anginine in patients with an intermediate to high risk of myocardial ischaemia undergoing MPS; ii) frequency and degree of fall in systolic blood pressure (SBP); iii) BP monitoring requirements; and iv) type of patient(s) prone to side effects. 63 patients (33M, 30F, mean age-67.2y) were included. Each was cannulated, drank two glasses of water, and lay supine prior to administration of anginine (1 x puff sublingually). 99Tcm-MIBI was administered 3-5 minutes later. BP measurements were obtained every five minutes for 20 minutes. SBP fell in 46/63 patients (range 5 - 40mmHg, mean 1 6mmHg, in 14 fall >20mmHg), and rose in 14/63. Maximal fall occurred 5-15 minutes post-administration of anginine (14 at 5min, 15 at 10min, 17 at 15min), returning toward baseline by 20 minutes in all patients. Seven patients developed a headache and two light-headedness; in all SBP fell >10mmHg. The quality of the scans was unaffected. There were 22(35%) abnormal studies - 14 reversible defects, two fixed defects, six cardiomyopathy (mean SBP tall 8.1mmHg, 8.6mmHg with normal study). LVEF was obtained in 33 patients; SBP fell in 24 (mean LVEF 57.8%), and rose in nine (mean LVEF 56.8%). The frequency and extent of hypotension in relation to age, sex, LVEF, or scan findings was not statistically significant. Anginine is sate to administer to patients undergoing MPS. Careful monitoring of the BP is recommended during the initial 20 minutes post-administration. No particular patient type was identified at higher risk. Copyright (2000) The Australian and New Zealand Society of Nuclear Medicine Inc

  7. Residual glycosaminoglycan accumulation in mitral and aortic valves of a patient with attenuated MPS I (Scheie syndrome after 6 years of enzyme replacement therapy: Implications for early diagnosis and therapy

    Yohei Sato

    2015-12-01

    Full Text Available Mucopolysaccharidosis (MPS is an inherited metabolic disease caused by deficiency of the enzymes needed for glycosaminoglycan (GAG degradation. MPS type I is caused by the deficiency of the lysosomal enzyme alpha-l-iduronidase and is classified into Hurler syndrome, Scheie syndrome, and Hurler–Scheie syndrome based on disease severity and onset. Cardiac complications such as left ventricular hypertrophy, cardiac valve disease, and coronary artery disease are often observed in MPS type I. Enzyme replacement therapy (ERT has been available for MPS type I, but the efficacy of this treatment for cardiac valve disease is unknown. We report on a 56-year-old female patient with attenuated MPS I (Scheie syndrome who developed aortic and mitral stenosis and coronary artery narrowing. The cardiac valve disease progressed despite ERT and she finally underwent double valve replacement and coronary artery bypass grafting. The pathology of the cardiac valves revealed GAG accumulation and lysosomal enlargement in both the mitral and aortic valves. Zebra body formation was also confirmed using electron microscopy. Our results suggest that ERT had limited efficacy in previously established cardiac valve disease. Early diagnosis and initiation of ERT is crucial to avoid further cardiac complications in MPS type I.

  8. S-system-based analysis of the robust properties common to many biochemical network models.

    Matsuoka, Yu; Jahan, Nusrat; Kurata, Hiroyuki

    2016-05-01

    Robustness is a key feature to characterize the adaptation of organisms to changes in their internal and external environments. A broad range of kinetic or dynamic models of biochemical systems have been developed. Robustness analyses are attractive for exploring some common properties of many biochemical models. To reveal such features, we transform different types of mathematical equations into a standard or intelligible formula and use the multiple parameter sensitivity (MPS) to identify some factors critically responsible for the total robustness to many perturbations. The MPS would be determined by the top quarter of the highly sensitive parameters rather than the single parameter with the maximum sensitivity. The MPS did not show any correlation to the network size. The MPS is closely related to the standard deviation of the sensitivity profile. A decrease in the standard deviation enhanced the total robustness, which shows the hallmark of distributed robustness that many factors (pathways) involve the total robustness. PMID:26861555

  9. Maximum Potential Score (MPS: An operating model for a successful customer-focused strategy.

    Cabello González, José Manuel

    2015-11-01

    Full Text Available One of marketers’ chief objectives is to achieve customer loyalty, which is a key factor for profitable growth. Therefore, they need to develop a strategy that attracts and maintains customers, giving them adequate motives, both tangible (prices and promotions and intangible (personalized service and treatment, to satisfy a customer and make him loyal to the company. Finding a way to accurately measure satisfaction and customer loyalty is very important. With regard to typical Relationship Marketing measures, we can consider listening to customers, which can help to achieve a competitive sustainable advantage. Customer satisfaction surveys are essential tools for listening to customers. Short questionnaires have gained considerable acceptance among marketers as a means to achieve a customer satisfaction measure. Our research provides an indication of the benefits of a short questionnaire (one/three questions. We find that the number of questions survey is significantly related to the participation in the survey (Net Promoter Score or NPS. We also prove that a the three question survey is more likely to have more participants than a traditional survey (Maximum Potential Score or MPS . Our main goal is to analyse one method as a potential predictor of customer loyalty. Using surveys, we attempt to empirically establish the causal factors in determining the satisfaction of customers. This paper describes a maximum potential operating model that captures with a three questions survey, important elements for a successful customer-focused strategy. MPS may give us lower participation rates than NPS but important information that helps to convert unhappy customers or just satisfied customers, into loyal customers.

  10. X-34 Main Propulsion System Design and Operation

    Champion, R. J., Jr.; Darrow, R. J., Jr.

    1998-01-01

    The X-34 program is a joint industry/government program to develop, test, and operate a small, fully-reusable hypersonic flight vehicle, utilizing technologies and operating concepts applicable to future Reusable Launch Vehicle (RLV) systems. The vehicle will be capable of Mach 8 flight to 250,000 feet altitude and will demonstrate an all composite structure, composite RP-1 tank, the Marshall Space Flight Center (MSFC) developed Fastrac engine, and the operability of an advanced thermal protection systems. The vehicle will also be capable of carrying flight experiments. MSFC is supporting the X-34 program in three ways: Program Management, the Fastrac engine as Government Furnished Equipment (GFE), and the design of the Main Propulsion System (MPS). The MPS Product Development Team (PDT) at MSFC is responsible for supplying the MPS design, analysis, and drawings to Orbital. The MPS consists of the LOX and RP-1 Fill, Drain, Feed, Vent, & Dump systems and the Helium & Nitrogen Purge, Pressurization, and Pneumatics systems. The Reaction Control System (RCS) design was done by Orbital. Orbital is the prime contractor and has responsibility for integration, procurement, and construction of all subsystems. The paper also discusses the design, operation, management, requirements, trades studies, schedule, and lessons learning with the MPS and RCS designs.

  11. Cascade Distillation System Development

    Callahan, Michael R.; Sargushingh, Miriam; Shull, Sarah

    2014-01-01

    NASA's Advanced Exploration Systems (AES) Life Support System (LSS) Project is chartered with de-veloping advanced life support systems that will ena-ble NASA human exploration beyond low Earth orbit (LEO). The goal of AES is to increase the affordabil-ity of long-duration life support missions, and to re-duce the risk associated with integrating and infusing new enabling technologies required to ensure mission success. Because of the robust nature of distillation systems, the AES LSS Project is pursuing develop-ment of the Cascade Distillation Subsystem (CDS) as part of its technology portfolio. Currently, the system is being developed into a flight forward Generation 2.0 design.

  12. A unique hinge binder of extremely selective aminopyridine-based Mps1 (TTK) kinase inhibitors with cellular activity.

    Kusakabe, Ken-ichi; Ide, Nobuyuki; Daigo, Yataro; Itoh, Takeshi; Yamamoto, Takahiko; Kojima, Eiichi; Mitsuoka, Yasunori; Tadano, Genta; Tagashira, Sachie; Higashino, Kenichi; Okano, Yousuke; Sato, Yuji; Inoue, Makiko; Iguchi, Motofumi; Kanazawa, Takayuki; Ishioka, Yukichi; Dohi, Keiji; Kido, Yasuto; Sakamoto, Shingo; Ando, Shigeru; Maeda, Masahiro; Higaki, Masayo; Yoshizawa, Hidenori; Murai, Hitoshi; Nakamura, Yusuke

    2015-05-01

    Mps1, also known as TTK, is a dual-specificity kinase that regulates the spindle assembly check point. Increased expression levels of Mps1 are observed in cancer cells, and the expression levels correlate well with tumor grade. Such evidence points to selective inhibition of Mps1 as an attractive strategy for cancer therapeutics. Starting from an aminopyridine-based lead 3a that binds to a flipped-peptide conformation at the hinge region in Mps1, elaboration of the aminopyridine scaffold at the 2- and 6-positions led to the discovery of 19c that exhibited no significant inhibition for 287 kinases as well as improved cellular Mps1 and antiproliferative activities in A549 lung carcinoma cells (cellular Mps1 IC₅₀=5.3 nM, A549 IC₅₀=26 nM). A clear correlation between cellular Mps1 and antiproliferative IC₅₀ values indicated that the antiproliferative activity observed in A549 cells would be responsible for the cellular inhibition of Mps1. The X-ray structure of 19c in complex with Mps1 revealed that this compound retains the ability to bind to the peptide flip conformation. Finally, comparative analysis of the X-ray structures of 19c, a deamino analogue 33, and a known Mps1 inhibitor bound to Mps1 provided insights into the unique binding mode at the hinge region. PMID:25801152

  13. Industrialized Information Systems Development

    Havn, Erling; Bansler, Jørgen P.

    1996-01-01

    The production of application software is rapidly being industrialized. Computer manufacturers and software houses produce a rapidly growing number of generic software applications and systems, and more and more user companies choose to build their computer-based information systems with such...... generic products, instead of custom made software. We discuss how the move away from traditional in-house development and the increasing use of generic software is likely to transform IS development in the near future. We conclude that these developments will make new demands on the information systems...

  14. Proceedings of the 1st Nordic Optimization Symposium - 10th Nordic MPS meeting, Copenhagen 2006

    Clausen, Jens; Jørgensen, Rene Munk; Kohl, Niklas;

    2006-01-01

    On behalf of the Technical University of Denmark, the Danish Operations Research Society and the Nordic Section of the Mathematical Programming Society we welcome you to Copenhagen and the 1st Nordic Optimization Symposium - the 10th meeting of the Nordic MPS. The meetings of the Nordic MPS have...... evolved to be more that just a meeting on Mathematical Programming. They are a forum for discussing a wide range of related areas and practical cases. In the organizing committee we wanted the name of the meeting to reflect this. We have therefore in agreement with the board of the Nordic MPS suggested to...... add a new title, that reflects the much broader field that is our playground at these meetings. Still the odd trustworthy title “Meeting of the Nordic MPS” has been maintained to demonstrate the origin of the symposium. It is our hope that future Nordic MPS meetings will carry on using this “double...

  15. Diagnosis and treatment trends in mucopolysaccharidosis I: findings from the MPS I Registry

    D’Aco, Kristin; Underhill, Lisa; Rangachari, Lakshmi; Arn, Pamela; Giugliani, Roberto; Okuyama, Torayuki; Wijburg, Frits; Kaplan, Paige; Cox, Gerald Frank

    2012-01-01

    Our objective was to assess how the diagnosis and treatment of mucopolysaccharidosis I (MPS I) have changed over time. We used data from 891 patients in the MPS I Registry, an international observational database, to analyze ages at symptom onset, diagnosis, treatment initiation, and treatment allocation (hematopoietic stem cell transplantation, enzyme replacement therapy with laronidase, both, or neither) over time for all disease phenotypes (Hurler, Hurler–Scheie, and Scheie syndromes). The...

  16. A chemical tool box defines mitotic and interphase roles for Mps1 kinase

    Lan, Weijie; Don W Cleveland

    2010-01-01

    In this issue, three groups (Hewitt et al. 2010. J. Cell Biol. doi:10.1083/jcb.201002133; Maciejowski et al. 2010. J. Cell Biol. doi:10.1083/jcb.201001050; Santaguida et al. 2010. J. Cell Biol. doi:10.1083/jcb.201001036) use chemical inhibitors to analyze the function of the mitotic checkpoint kinase Mps1. These studies demonstrate that Mps1 kinase activity ensures accurate chromosome segregation through its recruitment to kinetochores of mitotic checkpoint proteins, formation of interphase a...

  17. A generic expert system for materials processing in space

    Andersen, Kristinn; Cook, George E.; Strauss, Alvin M.

    1988-01-01

    A generic expert system is described for inspecting materials processed in space (MPS). The system may be applied, with the appropriate knowledge base, to any of the nondestructive testing methods (NDT) which are appropriate to MPS. Regardless of the method being used, the inspection process consists of three tasks: (1) signal or image processing of the NDT output and feature extraction, (2) interpretation of features in terms of MPS discontinuities, and (3) evaluation of the quality of the MPS based upon industry standards. In contrast to rule based systems, this system represents its knowledge as multidimensional vectors and appropriate functions on them. Currently, the expert system accepts manual input of observed features. Once the expert system has been tested and compared to human expert inspectors, a vision front-end will be developed to complete automation of the expert MPS inspection system, based on visual discontuities. Then the data base will be extended to include a variety of other NDT methods. In addition to functional performance, ease of use was established through menu window driven input as well as flexibility in building, using and modifying data bases for different applications.

  18. Evolutionary Information System Development

    Kristensen, Jan

    This paper offers advice to companies and professionals that implement e-commerce systems in business organizations. Implementing e-commerce systems is different from traditional IT implementation and thus requires a new set of tools and skills. The need for a novel approach is illustrated and...... necessary items that must be taken into account are pointed out by narrating two stories of e-commerce implementation processes in wholesale companies. The empirical evidence suggests the following: Managing the continued development on an operational level requires operational insight and understanding of...... business priorities. On a more theoretical level this suggests that we must revise our current understanding of systems development to cope....

  19. Power Systems Development Facility

    Southern Company Services

    2009-01-31

    In support of technology development to utilize coal for efficient, affordable, and environmentally clean power generation, the Power Systems Development Facility (PSDF), located in Wilsonville, Alabama, has routinely demonstrated gasification technologies using various types of coals. The PSDF is an engineering scale demonstration of key features of advanced coal-fired power systems, including a Transport Gasifier, a hot gas particulate control device, advanced syngas cleanup systems, and high-pressure solids handling systems. This final report summarizes the results of the technology development work conducted at the PSDF through January 31, 2009. Twenty-one major gasification test campaigns were completed, for a total of more than 11,000 hours of gasification operation. This operational experience has led to significant advancements in gasification technologies.

  20. Development of heating system

    The detailed designs and development of components of NBI, RF, ECH, and LHCD heating and current drive system have been performed. The prototype ion source for the KSTAR NBI system and the beam line components such as calorimeter, neutralizer, bending magnet, and ion dump had been developed. The power supplies for the stable beam of 120 kV and 65 A including acceleration power supply, deceleration power supply, arc power supply, and filament power supply have been developed. Finally a KSATR NB test facility has been completed at KAERI to test and upgrade the ion source and the beam line components. The RF system is under development. Antenna has been fabricated and tested. Transmission components (vacuum feedthrough, impedance matching and water-cooled transmission line) for transmitting MW level of power have been developed. For transmitter, we optimized performance of 100kW transmitter and completed the fabrication of 300 kW transmitter. We will finalize the procurement specification of 2 MW transmitter system in the third phase. The detailed design of a 500 kW, 84 GHz ECH system has been completed. The gyrotron has been fabricated and successfully tested at Communications and Power Industries(CPI), USA. It is delivered to POSTECH, and under short pulse conditioning test with a pulse modulator operated at 20 μs with 60 Hz repetition rate and a acceleration power supply (APS). The ECH transmission line components are being purchased from General Atomics (GA), USA. The LH frequency of the 2.0 MW LHCD system is chosen to 5.0 GHz for extending the density limit condition. The LHCD system is under design process. The basic design of the 5.0 GHz LHCD launcher (coupler) has been finished using the HFSS and ANSYS programs.

  1. A structured light sensor measuring method based on wMPS global controlling

    Chen, Yang; Lin, Jiarui; Guo, Yin; Gao, Yang; Yang, Shourui

    2015-10-01

    In large-scale three-dimensional (3D) coordinates measurement, to solve the problem of structured light sensor's measurement data from different measurement stations unifying to the global coordinate system, a method based on workshop Measuring Position System (wMPS) global controlling is researched to concentrate the structured light sensor's measurement data to the global coordinate system automatically. According to the measurement principle, two calibration methods are proposed to calibrate the structural parameters based on a standard ball, one is transferring stations based on common points and the other is fitting ball equation. Finally, a platform for experiment is built to verify the two calibration methods. Experimental results show that the average measurement error on 10 points is 0.127 mm according to the laser tracker of the first method and the other average error is 0.101 mm, both the two calibration methods have a high precision to meet the demands of large-scale 3D coordinates measurement.

  2. RSMASS system model development

    RSMASS system mass models have been used for more than a decade to make rapid estimates of space reactor power system masses. This paper reviews the evolution of the RSMASS models and summarizes present capabilities. RSMASS has evolved from a simple model used to make rough estimates of space reactor and shield masses to a versatile space reactor power system model. RSMASS uses unique reactor and shield models that permit rapid mass optimization calculations for a variety of space reactor power and propulsion systems. The RSMASS-D upgrade of the original model includes algorithms for the balance of the power system, a number of reactor and shield modeling improvements, and an automatic mass optimization scheme. The RSMASS-D suite of codes cover a very broad range of reactor and power conversion system options as well as propulsion and bimodal reactor systems. Reactor choices include in-core and ex-core thermionic reactors, liquid metal cooled reactors, particle bed reactors, and prismatic configuration reactors. Power conversion options include thermoelectric, thermionic, Stirling, Brayton, and Rankine approaches. Program output includes all major component masses and dimensions, efficiencies, and a description of the design parameters for a mass optimized system. In the past, RSMASS has been used as an aid to identify and select promising concepts for space power applications. The RSMASS modeling approach has been demonstrated to be a valuable tool for guiding optimization of the power system design; consequently, the model is useful during system design and development as well as during the selection process. An improved in-core thermionic reactor system model RSMASS-T is now under development. The current development of the RSMASS-T code represents the next evolutionary stage of the RSMASS models. RSMASS-T includes many modeling improvements and is planned to be more user-friendly. RSMASS-T will be released as a fully documented, certified code at the end of

  3. Development of Production Systems

    Christiansen, Thomas Bøhm

    This paper presents the initial considerations related to a Ph.D. study initiated at IPV, DTU in February 1997, concerning the research subject "Development of Production Systems". The content and aim of this paper is to 1) to introduce the study by......This paper presents the initial considerations related to a Ph.D. study initiated at IPV, DTU in February 1997, concerning the research subject "Development of Production Systems". The content and aim of this paper is to 1) to introduce the study by...

  4. Assessment of dysmyelination with RAFFn MRI: application to murine MPS I.

    David Satzer

    Full Text Available Type I mucopolysaccharidosis (MPS I is an autosomal recessive lysosomal storage disorder with neurological features. Humans and laboratory animals with MPS I exhibit various white matter abnormalities involving the corpus callosum and other regions. In this study, we first validated a novel MRI technique, entitled Relaxation Along a Fictitious Field in the rotating frame of rank n (RAFFn, as a measure of myelination and dysmyelination in mice. We then examined differences between MPS I mice and heterozygotes using RAFF5 and histology. RAFF5 (i.e., RAFFn with n = 5 relaxation time constants were highly correlated with histological myelin density (R2 = 0.68, P<0.001, and RAFF5 clearly distinguished between the hypomyelinated and dysmyelinated shiverer mouse and the wild-type mouse. Bloch-McConnell theoretical analysis revealed slower exchange correlation times and smaller exchange-induced relaxation rate constants for RAFF4 and RAFF5 compared to RAFF1-3, T1ρ, and T2ρ. These data suggest that RAFF5 may assess methylene protons in myelin lipids and proteins, though other mechanisms (e.g. detection of myelin-bound water may also explain the sensitivity of RAFF5 to myelin. In MPS I mice, mean RAFF5 relaxation time constants were significantly larger for the striatum (P = 0.004 and internal capsule (P = 0.039, and marginally larger for the fornix (P = 0.15. Histological assessment revealed no differences between MPS I mice and heterozygotes in myelin density or corpus callosum thickness. Taken together, these findings support subtle dysmyelination in the brains of mice with MPS I. Dysmyelination may result from myelin lipid abnormalities caused by the absence of α-L-iduronidase. Our findings may help to explain locomotor and cognitive deficits seen in mice with MPS I.

  5. Assessment of dysmyelination with RAFFn MRI: application to murine MPS I.

    Satzer, David; DiBartolomeo, Christina; Ritchie, Michael M; Storino, Christine; Liimatainen, Timo; Hakkarainen, Hanne; Idiyatullin, Djaudat; Mangia, Silvia; Michaeli, Shalom; Parr, Ann M; Low, Walter C

    2015-01-01

    Type I mucopolysaccharidosis (MPS I) is an autosomal recessive lysosomal storage disorder with neurological features. Humans and laboratory animals with MPS I exhibit various white matter abnormalities involving the corpus callosum and other regions. In this study, we first validated a novel MRI technique, entitled Relaxation Along a Fictitious Field in the rotating frame of rank n (RAFFn), as a measure of myelination and dysmyelination in mice. We then examined differences between MPS I mice and heterozygotes using RAFF5 and histology. RAFF5 (i.e., RAFFn with n = 5) relaxation time constants were highly correlated with histological myelin density (R2 = 0.68, P<0.001), and RAFF5 clearly distinguished between the hypomyelinated and dysmyelinated shiverer mouse and the wild-type mouse. Bloch-McConnell theoretical analysis revealed slower exchange correlation times and smaller exchange-induced relaxation rate constants for RAFF4 and RAFF5 compared to RAFF1-3, T1ρ, and T2ρ. These data suggest that RAFF5 may assess methylene protons in myelin lipids and proteins, though other mechanisms (e.g. detection of myelin-bound water) may also explain the sensitivity of RAFF5 to myelin. In MPS I mice, mean RAFF5 relaxation time constants were significantly larger for the striatum (P = 0.004) and internal capsule (P = 0.039), and marginally larger for the fornix (P = 0.15). Histological assessment revealed no differences between MPS I mice and heterozygotes in myelin density or corpus callosum thickness. Taken together, these findings support subtle dysmyelination in the brains of mice with MPS I. Dysmyelination may result from myelin lipid abnormalities caused by the absence of α-L-iduronidase. Our findings may help to explain locomotor and cognitive deficits seen in mice with MPS I. PMID:25680196

  6. Assessment of Dysmyelination with RAFFn MRI: Application to Murine MPS I

    Satzer, David; DiBartolomeo, Christina; Ritchie, Michael M.; Storino, Christine; Liimatainen, Timo; Hakkarainen, Hanne; Idiyatullin, Djaudat; Mangia, Silvia; Michaeli, Shalom; Parr, Ann M.; Low, Walter C.

    2015-01-01

    Type I mucopolysaccharidosis (MPS I) is an autosomal recessive lysosomal storage disorder with neurological features. Humans and laboratory animals with MPS I exhibit various white matter abnormalities involving the corpus callosum and other regions. In this study, we first validated a novel MRI technique, entitled Relaxation Along a Fictitious Field in the rotating frame of rank n (RAFFn), as a measure of myelination and dysmyelination in mice. We then examined differences between MPS I mice and heterozygotes using RAFF5 and histology. RAFF5 (i.e., RAFFn with n = 5) relaxation time constants were highly correlated with histological myelin density (R2 = 0.68, P<0.001), and RAFF5 clearly distinguished between the hypomyelinated and dysmyelinated shiverer mouse and the wild-type mouse. Bloch-McConnell theoretical analysis revealed slower exchange correlation times and smaller exchange-induced relaxation rate constants for RAFF4 and RAFF5 compared to RAFF1-3, T1ρ, and T2ρ. These data suggest that RAFF5 may assess methylene protons in myelin lipids and proteins, though other mechanisms (e.g. detection of myelin-bound water) may also explain the sensitivity of RAFF5 to myelin. In MPS I mice, mean RAFF5 relaxation time constants were significantly larger for the striatum (P = 0.004) and internal capsule (P = 0.039), and marginally larger for the fornix (P = 0.15). Histological assessment revealed no differences between MPS I mice and heterozygotes in myelin density or corpus callosum thickness. Taken together, these findings support subtle dysmyelination in the brains of mice with MPS I. Dysmyelination may result from myelin lipid abnormalities caused by the absence of α-L-iduronidase. Our findings may help to explain locomotor and cognitive deficits seen in mice with MPS I. PMID:25680196

  7. Mutagenic potential scale developed for relative evaluation of biological system response to environments presenting different gamma exposure rates

    The elaboration of a mutagenic potential scale (MPS) will be accomplished through the evaluation of the frequency of induced mutations in a plant biological system in different sites. The selection of these sites will be based on general public perception of risk to health. In this selection, it will include areas such ecological paradises and also neighborhoods of nuclear reactors and uranium mining and milling industry with potential radiological impact. The developed project foresees the contribution of other research groups that will also provide data from different sites. The referred scale will be built based on the response of the genetic system that gives color to the cells of Tradescantia (BNL 4430) stamen hair to mutagenic agents. Methodological improvements has been developed aiming the computerization of mutagenic events evaluation and statistical analysis of data that will significantly increase the efficiency of the system and obtention of results. Other biological systems of environmental quality are being added to the project, for future use. MPS should facilitate the general public and professionals of the nuclear area to understand risks, on a biological basis, of exposure from radiologically impacted environments. (author)

  8. Mobile systems development

    Pedersen, Ole; Kristiansen, Martin Lund; Kammersgaard, Marc N.;

    2007-01-01

    components whenever possible. Test regularly oil real devices, since the difference between emulators and real devices are significant. Take advantage of spikes. Do not use pair programming when spiking, and remember to write unit tests for production code that was initially created during spikes. Monitor......Development of mobile software is Surrounded by much uncertainty. Immature software platforms on mobile clients, a highly competitive market calling for innovation, efficiency and effectiveness in the development life cycle, and lacking end-user adoption are just some of the realities facing...... in XP. In general, we find XP well-suited for mobile systems development projects. However, based on our experiences and an analytical comparison we propose the following modifications to XP: Make an essential design to avoid the worst time waste during refactoring. For faster development, reuse code...

  9. Peripheral nervous system neuropathology and progressive sensory impairments in a mouse model of Mucopolysaccharidosis IIIB.

    Haiyan Fu

    Full Text Available The lysosomal storage pathology in Mucopolysaccharidosis (MPS IIIB manifests in cells of virtually all organs. However, it is the profound role of the neurological pathology that leads to morbidity and mortality in this disease, and has been the major challenge to developing therapies. To date, MPS IIIB neuropathologic and therapeutic studies have focused predominantly on changes in the central nervous system (CNS, especially in the brain, and little is known about the disease pathology in the peripheral nervous system (PNS. This study demonstrates characteristic lysosomal storage pathology in dorsal root ganglia affecting neurons, satellite cells (glia and Schwann cells. Lysosomal storage lesions were also observed in the myoenteric plexus and submucosal plexus, involving enteric neurons with enteric glial activation. Further, MPS IIIB mice developed progressive impairments in sensory functions, with significantly reduced response to pain stimulation that became detectable at 4-5 months of age as the disease progressed. These data demonstrate that MPS IIIB neuropathology manifests not only in the entire CNS but also the PNS, likely affecting both afferent and efferent neural signal transduction. This study also suggests that therapeutic development for MPS IIIB may benefit from targeting the entire nervous system.

  10. Geological disposal system development

    Kang, Chul Hyung; Kuh, J. E.; Kim, S. K. and others

    2000-04-01

    Spent fuel inventories to be disposed of finally and design base spent fuel were determined. Technical and safety criteria for a geological repository system in Korea were established. Based on the properties of spent PWR and CANDU fuels, seven repository alternatives were developed and the most promising repository option was selected by the pair-wise comparison method from the technology point of view. With this option preliminary conceptual design studies were carried out. Several module, e.g., gap module, congruent release module were developed for the overall assessment code MASCOT-K. The prominent overseas databases such as OECD/NEA FEP list were are fully reviewed and then screened to identify the feasible ones to reflect the Korean geo-hydrological conditions. In addition to this the well known scenario development methods such as PID, RES were reviewed. To confirm the radiological safety of the proposed KAERI repository concept the preliminary PA was pursued. Thermo-hydro-mechanical analysis for the near field of repository were performed to verify thermal and mechanical stability for KAERI repository system. The requirements of buffer material were analyzed, and based on the results, the quantitative functional criteria for buffer material were established. The hydraulic and swelling property, mechanical properties, and thermal conductivity, the organic carbon content, and the evolution of pore water chemistry were investigated. Based on the results, the candidate buffer material was selected.

  11. Geological disposal system development

    Spent fuel inventories to be disposed of finally and design base spent fuel were determined. Technical and safety criteria for a geological repository system in Korea were established. Based on the properties of spent PWR and CANDU fuels, seven repository alternatives were developed and the most promising repository option was selected by the pair-wise comparison method from the technology point of view. With this option preliminary conceptual design studies were carried out. Several module, e.g., gap module, congruent release module were developed for the overall assessment code MASCOT-K. The prominent overseas databases such as OECD/NEA FEP list were are fully reviewed and then screened to identify the feasible ones to reflect the Korean geo-hydrological conditions. In addition to this the well known scenario development methods such as PID, RES were reviewed. To confirm the radiological safety of the proposed KAERI repository concept the preliminary PA was pursued. Thermo-hydro-mechanical analysis for the near field of repository were performed to verify thermal and mechanical stability for KAERI repository system. The requirements of buffer material were analyzed, and based on the results, the quantitative functional criteria for buffer material were established. The hydraulic and swelling property, mechanical properties, and thermal conductivity, the organic carbon content, and the evolution of pore water chemistry were investigated. Based on the results, the candidate buffer material was selected

  12. Spectral and fluorescence imaging of immune system and tissue response to an immunogenic agent

    Choe, Se-woon; Acharya, Abhinav; Keselowsky, Benjamin G.; Sorg, Brian S.

    2009-05-01

    Imaging of immune system and tissue response to immunogenic agents can be important to the development of new biomaterials. Additionally, quantitative functional imaging can be useful for testing and evaluation of methods to alter or control the immune system response to implanted materials. In this preliminary study, we employ spectral imaging and fluorescence imaging to measure immune system and tissue response to implanted immunogenic agents. Poly (D,L lactide-co-glycolide) (PLGA) with a 50:50 composition was used to create immunogenic microparticles (MPs). Lipopolysaccharide (LPS) encapsulated in the MPs was used to provoke a tissue immune response in mice and encapsulated fluorescein isothiocyanate (FITC) was used to fluorescently label the MPs for imaging. Control MPs did not contain LPS. The MPs were delivered at 50 particles/μL in a total volume of 20μL by subcutaneous injection in the skin of a nude mouse in a dorsal skin-fold window chamber preparation. Cultured immune cells from a mouse leukemic monocyte macrophage cell line were exogenously labeled with the fluorescent dye DiD in solution at a concentration of 8000cells/μL. Immediately after window chamber surgery and implantation of the MPs, 100μL of the fluorescent macrophage solution was administered via the tail vein. Fluorescence imaging was used to track MPs and macrophages while spectral imaging was used for imaging and measurement of hemoglobin saturation in the tissue microvasculature. Imaging was performed periodically over about three days. The spectral and fluorescence imaging combination enabled detailed observations of the macrophage response and functional effects on the tissue.

  13. Sepsis and development impede muscle protein synthesis in neonatal pigs by different ribosomal mechanisms

    In muscle, sepsis reduces protein synthesis (MPS) by restraining translation in neonates and adults. Even though protein accretion decreases with development as neonatal MPS rapidly declines by maturation, the changes imposed by development on the sepsis-associated decrease in MPS have not been desc...

  14. Power Systems Development Facility

    None

    2003-07-01

    This report discusses Test Campaign TC12 of the Kellogg Brown & Root, Inc. (KBR) Transport Gasifier train with a Siemens Westinghouse Power Corporation (SW) particle filter system at the Power Systems Development Facility (PSDF) located in Wilsonville, Alabama. The Transport Gasifier is an advanced circulating fluidized-bed reactor designed to operate as either a combustor or a gasifier using a particulate control device (PCD). While operating as a gasifier, either air or oxygen can be used as the oxidant. Test run TC12 began on May 16, 2003, with the startup of the main air compressor and the lighting of the gasifier start-up burner. The Transport Gasifier operated until May 24, 2003, when a scheduled outage occurred to allow maintenance crews to install the fuel cell test unit and modify the gas clean-up system. On June 18, 2003, the test run resumed when operations relit the start-up burner, and testing continued until the scheduled end of the run on July 14, 2003. TC12 had a total of 733 hours using Powder River Basin (PRB) subbituminous coal. Over the course of the entire test run, gasifier temperatures varied between 1,675 and 1,850 F at pressures from 130 to 210 psig.

  15. Power Systems Development Facility

    The objective of the PSDF would be to provide a modular facility which would support the development of advanced, pilot-scale, coal-based power systems and hot gas clean-up components. These pilot-scale components would be designed to be large enough so that the results can be related and projected to commercial systems. The facility would use a modular approach to enhance the flexibility and capability for testing; consequently, overall capital and operating costs when compared with stand-alone facilities would be reduced by sharing resources common to different modules. The facility would identify and resolve technical barrier, as well as-provide a structure for long-term testing and performance assessment. It is also intended that the facility would evaluate the operational and performance characteristics of the advanced power systems with both bituminous and subbituminous coals. Five technology-based experimental modules are proposed for the PSDF: (1) an advanced gasifier module, (2) a fuel cell test module, (3) a PFBC module, (4) a combustion gas turbine module, and (5) a module comprised of five hot gas cleanup particulate control devices. The final module, the PCD, would capture coal-derived ash and particles from both the PFBC and advanced gasifier gas streams to provide for overall particulate emission control, as well as to protect the combustion turbine and the fuel cell

  16. Advanced Dewatering Systems Development

    R.H. Yoon; G.H. Luttrell

    2008-07-31

    A new fine coal dewatering technology has been developed and tested in the present work. The work was funded by the Solid Fuels and Feedstocks Grand Challenge PRDA. The objective of this program was to 'develop innovative technical approaches to ensure a continued supply of environmentally sound solid fuels for existing and future combustion systems with minimal incremental fuel cost.' Specifically, this solicitation is aimed at developing technologies that can (i) improve the efficiency or economics of the recovery of carbon when beneficiating fine coal from both current production and existing coal slurry impoundments and (ii) assist in the greater utilization of coal fines by improving the handling characteristics of fine coal via dewatering and/or reconstitution. The results of the test work conducted during Phase I of the current project demonstrated that the new dewatering technologies can substantially reduce the moisture from fine coal, while the test work conducted during Phase II successfully demonstrated the commercial viability of this technology. It is believed that availability of such efficient and affordable dewatering technology is essential to meeting the DOE's objectives.

  17. The machine protection system for the R&D energy recovery LINAC

    Altinbas, Z.; Kayran, D.; Jamilkowski, J.; Lee, R.C.; Oerter, B.

    2011-03-28

    The Machine Protection System (MPS) is a device-safety system that is designed to prevent damage to hardware by generating interlocks, based upon the state of input signals generated by selected sub-systems. It protects all the key machinery in the R&D Project called the Energy Recovery LINAC (ERL) against the high beam current. The MPS is capable of responding to a fault with an interlock signal within several microseconds. The ERL MPS is based on a National Instruments CompactRIO platform, and is programmed by utilizing National Instruments' development environment for a visual programming language. The system also transfers data (interlock status, time of fault, etc.) to the main server. Transferred data is integrated into the pre-existing software architecture which is accessible by the operators. This paper will provide an overview of the hardware used, its configuration and operation, as well as the software written both on the device and the server side.

  18. SIT-5 system development.

    Hyman, J., Jr.

    1972-01-01

    A 5-cm structurally integrated ion thruster (SIT-5) has been developed for attitude control and stationkeeping of synchronous satellites. With two-dimension thrust-vectoring grids, a first generation unit has demonstrated a thrust of 0.56 mlb at a beam voltage of 1200 V, total mass efficiency of 64%, and electrical efficiency of 46.8%. Structural integrity is demonstrated with a dielectric-coated grid for shock (30 G), sinusoidal (9 G), and random (19.9 G rms) accelerations. System envelope is 31.8 cm long by 13.9 cm flange bolt circle, with a mass of 8.5 kg, including 6.2 kg mercury propellant. Characteristics of a second-generation unit indicate significant performance gains.

  19. Analysis of male reproductive parameters in a murine model of mucopolysaccharidosis type I (MPS I)

    do Nascimento, Cinthia Castro; Junior, Odair Aguiar; D’Almeida, Vânia

    2014-01-01

    Mucopolysaccharidosis (MPS) I is a lysosomal storage disorder (LSD) that is characterised by alpha-L-iduronidase (Idua) deficiency and continuous deposition of glycosaminoglycans (GAGs), which consequently interferes with cell signalling mechanisms and results in multisystemic and progressive symptoms. The animal model of MPS I (Idua-/-) has been widely studied to elucidate the consequences and progression of the disorder; however, studies specifically assessing the male reproductive tract are lacking. The aim of this study was to evaluate some of the reproductive characteristics of male MPS I mice in two phases of life. Reproductive organ biometry, sperm counts, sperm morphological evaluation, plasma testosterone measurements and histopathological, histomorphometrical and immunohistochemical analysis were performed in 3- and 6-month-old C57BL/6 Idua+/+ and Idua-/- mice. Seminal vesicle weights were decreased in both the 3- and 6-month-old Idua-/- mice. Decrease in sperm counts and the majority of the histopathological signs were observed in the 6-month-old Idua-/- mice. No differences were detected in the sperm morphological analysis. Immunohistochemistry revealed that seminiferous tubules from 3-month-old Idua-/- mice were more intensely stained with anti-caspase-3 than 3-month-old Idua+/+ mice, but no difference was found at 6 months. These results suggest that MPS I interferes with male reproductive parameters both in 3 and 6-month-old animals and histopathological signs are more pronounced in 6-month-old mice, indicating that the effects of the disorder may intensify with the disease progression. PMID:25031781

  20. Identifying the need for a multidisciplinary approach for early recognition of mucopolysaccharidosis VI (MPS VI).

    Choy, Yew Sing; Bhattacharya, Kaustuv; Balasubramaniam, Shanti; Fietz, Michael; Fu, Antony; Inwood, Anita; Jin, Dong-Kyu; Kim, Ok-Hwa; Kosuga, Motomichi; Kwun, Young Hee; Lin, Hsiang-Yu; Lin, Shuan-Pei; Mendelsohn, Nancy J; Okuyama, Torayuki; Samion, Hasri; Tan, Adeline; Tanaka, Akemi; Thamkunanon, Verasak; Thong, Meow-Keong; Toh, Teck-Hock; Yang, Albert D; McGill, Jim

    2015-05-01

    Mucopolysaccharidosis VI (MPS VI, Maroteaux-Lamy syndrome) is caused by deficient activity of the enzyme, N-acetylgalactosamine-4-sulfatase, resulting in impaired degradation of the glycosaminoglycan dermatan sulfate. Patients experience a range of manifestations including joint contractures, short stature, dysostosis multiplex, coarse facial features, decreased pulmonary function, cardiac abnormalities, corneal clouding and shortened life span. Recently, clinicians from institutions in the Asia-Pacific region met to discuss the occurrence and implications of delayed diagnosis and misdiagnosis of MPS VI in the patients they have managed. Eighteen patients (44% female) were diagnosed. The most common sign presented by the patients was bone deformities in 11 patients (65%). Delays to diagnosis occurred due to the lack of or distance to diagnostic facilities for four patients (31%), alternative diagnoses for two patients (15%), and misleading symptoms experienced by two patients (15%). Several patients experienced manifestations that were subtler than would be expected and were subsequently overlooked. Several cases highlighted the unique challenges associated with diagnosing MPS VI from the perspective of different specialties and provide insights into how these patients initially present, which may help to elucidate strategies to improve the diagnosis of MPS VI. PMID:25892708

  1. Numerical analysis of isothermal JET injection into a denser liquid pool using RD-MPS Method

    Park, S. [KEPCO Nuclear Fuel, Daejeon (Korea, Republic of); Park, H. S. [POSTECH, Pohang (Korea, Republic of); Jeun, G. [Hanyang Univ., Seoul (Korea, Republic of)

    2012-03-15

    In this study, the rigid body dynamics coupled moving particle semi-implicit (RD-MPS) method was used to simulate a plunging liquid jet penetrating into a denser liquid pool. The phenomenon is related to fuel-coolant interactions (FCI) during severe accidents in nuclear power plants when coolant water is forcedly injected into a melt pool. A numerical particle method like MPS enables to simulate the complex multiphase flow in that significant deformation of fluids occurs due to its inherent grid less algorithm. However, the MPS method alone cannot continue the calculation for a long time as shown in the Ikea's work due to the large deformation of fluid surfaces and the difference in both liquid densities. In the RD-MPS method, the rigid body dynamics was coupled with the moving particle semi-implicit method to increase the overall stability of calculations and to calculate the multi-phase behavior of fluids. We performed two and three dimensional calculations to simulate jet penetration behaviors in a denser liquid pool, and the result was in good agreement with that of experiment. The simulation results suggested that the coupled model be useful in simulating dynamic interactions of multi-phase incompressible fluids as well as that the 3-D simulation for the plunging jet in a confined geometry predicted better agreement with experimental results than the 2-D simulation did.

  2. Numerical analysis of isothermal JET injection into a denser liquid pool using RD-MPS Method

    In this study, the rigid body dynamics coupled moving particle semi-implicit (RD-MPS) method was used to simulate a plunging liquid jet penetrating into a denser liquid pool. The phenomenon is related to fuel-coolant interactions (FCI) during severe accidents in nuclear power plants when coolant water is forcedly injected into a melt pool. A numerical particle method like MPS enables to simulate the complex multiphase flow in that significant deformation of fluids occurs due to its inherent grid less algorithm. However, the MPS method alone cannot continue the calculation for a long time as shown in the Ikea's work due to the large deformation of fluid surfaces and the difference in both liquid densities. In the RD-MPS method, the rigid body dynamics was coupled with the moving particle semi-implicit method to increase the overall stability of calculations and to calculate the multi-phase behavior of fluids. We performed two and three dimensional calculations to simulate jet penetration behaviors in a denser liquid pool, and the result was in good agreement with that of experiment. The simulation results suggested that the coupled model be useful in simulating dynamic interactions of multi-phase incompressible fluids as well as that the 3-D simulation for the plunging jet in a confined geometry predicted better agreement with experimental results than the 2-D simulation did

  3. Use of the Quest Myocardial Protection System” (MPS) for Modified Ultrafiltration During Pediatric Cardiac Surgery

    Trowbridge, Cody C.; Stammers, Alfred H.; Klayman, Myra H.; Murdock, James D.; Yen, Bianca R.; Gilbert, Christian L.

    2005-01-01

    Modified ultrafiltration generally is considered a standard of care for treating children undergoing cardiopulmonary bypass for congenital heat surgery. Different methods, incorporating a variety of devices and technologies, have been described. The present report describes a technique of modified ultrafiltration using arterial-venous flow with the Quest Myocardial Protection System™ (MPS).

  4. Power Systems Development Facility

    Southern Company Services

    2004-04-30

    This report discusses Test Campaign TC15 of the Kellogg Brown & Root, Inc. (KBR) Transport Gasifier train with a Siemens Power Generation, Inc. (SPG) particle filter system at the Power Systems Development Facility (PSDF) located in Wilsonville, Alabama. The Transport Gasifier is an advanced circulating fluidized-bed reactor designed to operate as either a combustor or gasifier using a particulate control device (PCD). While operating as a gasifier, either air or oxygen can be used as the oxidant. Test run TC15 began on April 19, 2004, with the startup of the main air compressor and the lighting of the gasifier startup burner. The Transport Gasifier was shutdown on April 29, 2004, accumulating 200 hours of operation using Powder River Basin (PRB) subbituminous coal. About 91 hours of the test run occurred during oxygen-blown operations. Another 6 hours of the test run was in enriched-air mode. The remainder of the test run, approximately 103 hours, took place during air-blown operations. The highest operating temperature in the gasifier mixing zone mostly varied from 1,800 to 1,850 F. The gasifier exit pressure ran between 200 and 230 psig during air-blown operations and between 110 and 150 psig in oxygen-enhanced air operations.

  5. POWER SYSTEMS DEVELOPMENT FACILITY

    Unknown

    2002-11-01

    This report discusses test campaign GCT4 of the Kellogg Brown & Root, Inc. (KBR) transport reactor train with a Siemens Westinghouse Power Corporation (Siemens Westinghouse) particle filter system at the Power Systems Development Facility (PSDF) located in Wilsonville, Alabama. The transport reactor is an advanced circulating fluidized-bed reactor designed to operate as either a combustor or a gasifier using one of two possible particulate control devices (PCDs). The transport reactor was operated as a pressurized gasifier during GCT4. GCT4 was planned as a 250-hour test run to continue characterization of the transport reactor using a blend of several Powder River Basin (PRB) coals and Bucyrus limestone from Ohio. The primary test objectives were: Operational Stability--Characterize reactor loop and PCD operations with short-term tests by varying coal-feed rate, air/coal ratio, riser velocity, solids-circulation rate, system pressure, and air distribution. Secondary objectives included the following: Reactor Operations--Study the devolatilization and tar cracking effects from transient conditions during transition from start-up burner to coal. Evaluate the effect of process operations on heat release, heat transfer, and accelerated fuel particle heat-up rates. Study the effect of changes in reactor conditions on transient temperature profiles, pressure balance, and product gas composition. Effects of Reactor Conditions on Synthesis Gas Composition--Evaluate the effect of air distribution, steam/coal ratio, solids-circulation rate, and reactor temperature on CO/CO{sub 2} ratio, synthesis gas Lower Heating Value (LHV), carbon conversion, and cold and hot gas efficiencies. Research Triangle Institute (RTI) Direct Sulfur Recovery Process (DSRP) Testing--Provide syngas in support of the DSRP commissioning. Loop Seal Operations--Optimize loop seal operations and investigate increases to previously achieved maximum solids-circulation rate.

  6. Particle precipitation and mixing simulated by rigid dynamic-moving particle semi-implicit (RD-MPS) method

    The particle precipitation and mixing related to the corium debris bed formation and coolability in severe accidents are investigated by using a new CFD tool, called the ADDA code. The code is developed based on an enhanced particle method which combines the MPS (Moving Particle Semi-implicit) algorithm with the rigid body dynamics method. The analysis successively simulates the entire process of debris bed formation which includes corium jet breakup, mixing, and sedimentation to identify the key characteristics to form the corium debris bed with coolable configurations. The 2-D and 3-D simulation re-created the detailed flow structures and mixing phenomena and final sedimentation process. For the analysis of the debris formation, it is suggested that the full 3-D simulation provides more accurate prediction than ones from the 2-D simulations since the debris formation largely depends on the process of particle precipitation and mixing phenomena prior to its settlement. (author)

  7. Circulating microparticles and plasma levels of soluble E- and P-selectins in patients with systemic sclerosis

    Iversen, Lars; Østergaard, O; Ullman, S; Nielsen, C T; Halberg, P; Karlsmark, T; Heegaard, Niels Henrik Helweg; Jacobsen, Søren

    2013-01-01

    Microparticles (MPs) may be involved in the pathogenesis of systemic sclerosis (SSc), which includes vasculopathy, endothelial cell activation, and coagulation activation. Circulating MPs from SSc patients were characterized and their relationship with soluble markers of vascular activation inves...

  8. Modified Projective Synchronization between Different Fractional-Order Systems Based on Open-Plus-Closed-Loop Control and Its Application in Image Encryption

    Hongjuan Liu

    2014-01-01

    Full Text Available A new general and systematic coupling scheme is developed to achieve the modified projective synchronization (MPS of different fractional-order systems under parameter mismatch via the Open-Plus-Closed-Loop (OPCL control. Based on the stability theorem of linear fractional-order systems, some sufficient conditions for MPS are proposed. Two groups of numerical simulations on the incommensurate fraction-order system and commensurate fraction-order system are presented to justify the theoretical analysis. Due to the unpredictability of the scale factors and the use of fractional-order systems, the chaotic data from the MPS is selected to encrypt a plain image to obtain higher security. Simulation results show that our method is efficient with a large key space, high sensitivity to encryption keys, resistance to attack of differential attacks, and statistical analysis.

  9. POWER SYSTEMS DEVELOPMENT FACILITY

    Unknown

    2002-05-01

    This report discusses test campaign GCT3 of the Halliburton KBR transport reactor train with a Siemens Westinghouse Power Corporation (Siemens Westinghouse) particle filter system at the Power Systems Development Facility (PSDF) located in Wilsonville, Alabama. The transport reactor is an advanced circulating fluidized-bed reactor designed to operate as either a combustor or a gasifier using one of two possible particulate control devices (PCDs). The transport reactor was operated as a pressurized gasifier during GCT3. GCT3 was planned as a 250-hour test run to commission the loop seal and continue the characterization of the limits of operational parameter variations using a blend of several Powder River Basin coals and Bucyrus limestone from Ohio. The primary test objectives were: (1) Loop Seal Commissioning--Evaluate the operational stability of the loop seal with sand and limestone as a bed material at different solids circulation rates and establish a maximum solids circulation rate through the loop seal with the inert bed. (2) Loop Seal Operations--Evaluate the loop seal operational stability during coal feed operations and establish maximum solids circulation rate. Secondary objectives included the continuation of reactor characterization, including: (1) Operational Stability--Characterize the reactor loop and PCD operations with short-term tests by varying coal feed, air/coal ratio, riser velocity, solids circulation rate, system pressure, and air distribution. (2) Reactor Operations--Study the devolatilization and tar cracking effects from transient conditions during transition from start-up burner to coal. Evaluate the effect of process operations on heat release, heat transfer, and accelerated fuel particle heat-up rates. Study the effect of changes in reactor conditions on transient temperature profiles, pressure balance, and product gas composition. (3) Effects of Reactor Conditions on Syngas Composition--Evaluate the effect of air distribution, steam

  10. Developing individuals for developing learning based systems

    Selamat, Mohamad

    2005-01-01

    This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University. This research is concerned with investigating the externalisation, sharing and making tangible of tacit knowledge in the context of organisational learning (OL). The externalisation, sharing and making tangible of tacit knowledge can provide “inputs” for Information Systems (IS) development. This process, in turn, can become a basis for the development of a system that is capable of promoting...

  11. Career Development: A Systems Approach.

    Slavenski, Lynn

    1987-01-01

    The author describes a comprehensive career development system implemented by Coca-Cola USA. The system's objectives are (1) to promote from within, (2) to develop talent for the future, (3) to make managers responsible for development efforts, and (4) to make individuals ultimately responsible for their development. (CH)

  12. Benefits of advanced software techniques for mission planning systems

    Gasquet, A.; Parrod, Y.; Desaintvincent, A.

    1994-01-01

    The increasing complexity of modern spacecraft, and the stringent requirement for maximizing their mission return, call for a new generation of Mission Planning Systems (MPS). In this paper, we discuss the requirements for the Space Mission Planning and the benefits which can be expected from Artificial Intelligence techniques through examples of applications developed by Matra Marconi Space.

  13. A new MPS {sup trademark} mill for the Veltheim Power Station

    Baumeister, W. [Gemeinschaftskraftwerk Weser GmbH, Veltheim (Germany); Bischoff, W.; Pannen, H. [BBP Energy GmbH, Oberhausen (Germany)

    2002-07-01

    Extensive tests in the coal grinding test field and in the flow laboratory, form together with the advanced CFD calculations as well as operating experience with over 2000 operating MPS ring and roller mills, the basis for the design of a new mill. In this the well-known principle of the MPS type ring and roller mill as best representative for hard coal pulverising worldwide has been retained. Tests at the size reduction model have shown that there is further potential for a higher output capacity. By means of new design and operating parameters the capacity was increased by more than 30%. It was necessary to verify these results at a test mill in a power plant. (orig.)

  14. Numerical analysis of jet injection mechanism of fuel-coolant interactions using MPS

    The numerical method used in this study is Moving Particle Semi-implicit (MPS) method which is based on moving particles and their interactions. Grids are not necessary, so that large fluid deformation can be calculated without numerical diffusion. To understand the fundamental physics of the jet penetration, water jet injection into a pool of a denser fluid under non-boiling and isothermal conditions is calculated using the MPS method. The density ratio of the denser fluid (Fluorinert) to water is 1.88. The calculation results are compared with experiments which were conducted in the ALPHA/MUSE facility at JAERI. In three-dimensional calculation, the penetration behavior agrees with the experiment. It is found that the jet penetration process is divided to two stages and, at the first stage, the coolant jet can penetrate deeper than existing correlations of breakup length. (author)

  15. Preparation of P(DVB-co-MPS) inorganic-organic hybrid polymer microspheres

    Wu, Chunrong; Zhang, Jimei; Dai, Zhao; Chen, Xiaoyu

    2010-07-01

    A novel inorganic-organic hybrid polymer microspheres were facilely synthesised by distillation-precipitation polymerization in absence of any stabilizer or surfcant. The process were conducted with [3-(Methacryloyloxy) propyl] trimethoxysilan (MPS) as monomer, divinyl benzene (DVB) as cross linking agent and azobisisobutyronitrile (AIBN) as initator in acetonitrile. A series of silica nanoparticles were prepared in accordance with the volume ratio of MPS, which was varied in the range of 10% to 50%. However, there is no microspheres obtained while the ratio up to 50%. Products were charactered by transmission electron micrograph (TEM) and fourier transform infrared spectroscopy (FTIR). We may infer it from the constructional formular and FTIR graph that there were silicon hydroxyl remained in the microsphere surface.

  16. Enzyme replacement therapy for Mucopolysaccharidosis Type I among patients followed within the MPS Brazil Network

    Alícia Dorneles Dornelles

    2014-01-01

    Full Text Available Mucopolysaccharidosis type I (MPS I is a rare lysosomal disorder caused by deficiency of alph-L-iduronidase. Few clinical trials have assessed the effect of enzyme replacement therapy (ERT for this condition. We conducted an exploratory, open-label, non-randomized, multicenter cohort study of patients with MPS I. Data were collected from questionnaires completed by attending physicians at the time of diagnosis (T1; n = 34 and at a median time of 2.5 years later (T2; n = 24/34. The 24 patients for whom data were available at T2 were allocated into groups: A, no ERT (9 patients; median age at T1 = 36 months; 6 with severe phenotype; B, on ERT (15 patients; median age at T1 = 33 months; 4 with severe phenotype. For all variables in which there was no between-group difference at baseline, a delta of ;±20% was considered clinically relevant. The following clinically relevant differences were identified in group B in T2: lower rates of mortality and reported hospitalization for respiratory infection; lower frequency of hepatosplenomegaly; increased reported rates of obstructive sleep apnea syndrome and hearing loss; and stabilization of gibbus deformity. These changes could be due to the effect of ERT or of other therapies which have also been found more frequently in group B. Our findings suggest MPS I patients on ERT also receive a better overall care. ERT may have a positive effect on respiratory morbidity and overall mortality in patients with MPS I. Additional studies focusing on these outcomes and on other therapies should be performed.

  17. Framework for control system development

    Control systems being developed for the present generation of accelerators will need to adapt to changing machine and operating state conditions. Such systems must also be capable of evolving over the life of the accelerator operation. In this paper we present a framework for the development of adaptive control systems

  18. Arcjet system integration development

    Zafran, Sidney

    1994-01-01

    Compatibility between an arcjet propulsion system and a communications satellite was verified by testing a Government-furnished, 1.4 kW hydrazine arcjet system with the FLTSATCOM qualification model satellite in a 9.1-meter (30-foot) diameter thermal-vacuum test chamber. Background pressure was maintained at 10(exp -5) torr during arcjet operation by cryopumping the thruster exhaust with an array of 5 K liquid helium cooled panels. Power for the arcjet system was obtained from the FLTSATCOM battery simulator. Spacecraft telemetry was monitored during each thruster firing period. No changes in telemetry data attributable to arcjet operation were detected in any of the tests. Electromagnetic compatibility data obtained included radiated emission measurements, conducted emission measurements, and cable coupling measurements. Significant noise was observed at lower frequencies. Above 500 MHz, radiated emissions were generally within limits, indicating that communication links at S-band and higher frequencies will not be affected. Other test data taken with a diagnostic array of calorimeters, radiometers, witness plates, and a residual gas analyzer evidenced compatible operation, and added to the data base for arcjet system integration. Two test series were conducted. The first series only included the arcjet and diagnostic array operating at approximately 0.1 torr background pressure. The second series added the qualification model spacecraft, a solar panel, and the helium cryopanels. Tests were conducted at 0.1 torr and 10(exp-5) torr. The arcjet thruster was canted 20 degrees relative to the solar panel axis, typical of the configuration used for stationkeeping thrusters on geosynchronous communications satellites.

  19. Arcjet system integration development

    Zafran, Sidney

    1994-03-01

    Compatibility between an arcjet propulsion system and a communications satellite was verified by testing a Government-furnished, 1.4 kW hydrazine arcjet system with the FLTSATCOM qualification model satellite in a 9.1-meter (30-foot) diameter thermal-vacuum test chamber. Background pressure was maintained at 10(exp -5) torr during arcjet operation by cryopumping the thruster exhaust with an array of 5 K liquid helium cooled panels. Power for the arcjet system was obtained from the FLTSATCOM battery simulator. Spacecraft telemetry was monitored during each thruster firing period. No changes in telemetry data attributable to arcjet operation were detected in any of the tests. Electromagnetic compatibility data obtained included radiated emission measurements, conducted emission measurements, and cable coupling measurements. Significant noise was observed at lower frequencies. Above 500 MHz, radiated emissions were generally within limits, indicating that communication links at S-band and higher frequencies will not be affected. Other test data taken with a diagnostic array of calorimeters, radiometers, witness plates, and a residual gas analyzer evidenced compatible operation, and added to the data base for arcjet system integration. Two test series were conducted. The first series only included the arcjet and diagnostic array operating at approximately 0.1 torr background pressure. The second series added the qualification model spacecraft, a solar panel, and the helium cryopanels. Tests were conducted at 0.1 torr and 10(exp-5) torr. The arcjet thruster was canted 20 degrees relative to the solar panel axis, typical of the configuration used for stationkeeping thrusters on geosynchronous communications satellites.

  20. Liferay Portal Systems Development

    Yuan, Jonas X

    2012-01-01

    This book focuses on teaching by example. Every chapter provides an overview, and then dives right into hands-on examples so you can see and play with the solution in your own environment. This book is for Java developers who don't need any prior experience with Liferay portal. Although Liferay portal makes heavy use of open source frameworks, no prior experience of using these is assumed.

  1. Geodyn systems development

    Putney, B. H.

    1984-01-01

    The purpose of the GEODYN Orbit Determination and Parameter Estimation, the SOLVE and ERODYN Programs is to recover geodetic and geophysical parameters from satellite and other data in a state-of-the-art manner. Continued solutions for gravity field, pole positions, Earth rotation, GM, and baselines were made as part of the Crustal Dynamics Project. Some tidal parameters were recovered as well. The eight digit station identification number was incorporated in the software and new techniques for constraining monthly station parameters to each other are being developed. This is allowing the analysts even more flexibility in the shaping of solutions from monthly sets of normal equations and right-hand sides.

  2. MEASUREMENT PROCESS OF SOFTWARE DEVELOPMENT PROJECTS FOR SUPPORTING STRATEGIC BUSINESS OBJECTIVES IN SOFTWARE DEVELOPING COMPANIES

    Sandra Lais Pedroso; Leonardo Rocha de Oliveira

    2013-01-01

    Software developing companies work in a competitive market and are often challenged to make business decisions with impact on competitiveness. Models accessing maturity for software development processes quality, such as CMMI and MPS-BR, comprise process measurements systems (PMS). However, these models are not necessarily suitable to support business decisions, neither to achieve strategic goals. The objective of this work is to analyze how the PMS of software development projects could supp...

  3. HLW Disposal System Development

    A KRS is suggested through design requirement analysis of the buffer and the canister which are the constituent of disposal system engineered barrier and HLW management plans are proposed. In the aspect of radionuclide retention capacity, the thickness of the buffer is determined 0.5m, the shape to be disc and ring and the dry density to be 1.6 g/cm3. The maximum temperature of the buffer is below 100 .deg. which meets the design requirement. And bentonite blocks with 5 wt% of graphite showed more than 1.0 W/mK of thermal conductivity without the addition of sand. The result of the thermal analysis for proposed double-layered buffer shows that decrease of 7 .deg. C in maximum temperature of the buffer. For the disposal canister, the copper for the outer shell material and cast iron for the inner structure material is recommended considering the results analyzed in terms of performance of the canisters and manufacturability and the geochemical properties of deep groundwater sampled from the research area with granite, salt water intrusion, and the heavy weight of the canister. The results of safety analysis for the canister shows that the criticality for the normal case including uncertainty is the value of 0.816 which meets subcritical condition. Considering nation's 'Basic Plan for Electric Power Demand and Supply' and based on the scenario of disposing CANDU spent fuels in the first phase, the disposal system that the repository will be excavated in eight phases with the construction of the Underground Research Laboratory (URL) beginning in 2020 and commissioning in 2040 until the closure of the repository is proposed. Since there is close correlation between domestic HLW management plans and front-end/back-end fuel cycle plans causing such a great sensitivity of international environment factor, items related to assuring the non-proliferation and observing the international standard are showed to be the influential factor and acceptability of HLW management

  4. HLW Disposal System Development

    Choi, J. W.; Choi, H. J.; Lee, J. Y. (and others)

    2007-06-15

    A KRS is suggested through design requirement analysis of the buffer and the canister which are the constituent of disposal system engineered barrier and HLW management plans are proposed. In the aspect of radionuclide retention capacity, the thickness of the buffer is determined 0.5m, the shape to be disc and ring and the dry density to be 1.6 g/cm{sup 3}. The maximum temperature of the buffer is below 100 .deg. which meets the design requirement. And bentonite blocks with 5 wt% of graphite showed more than 1.0 W/mK of thermal conductivity without the addition of sand. The result of the thermal analysis for proposed double-layered buffer shows that decrease of 7 .deg. C in maximum temperature of the buffer. For the disposal canister, the copper for the outer shell material and cast iron for the inner structure material is recommended considering the results analyzed in terms of performance of the canisters and manufacturability and the geochemical properties of deep groundwater sampled from the research area with granite, salt water intrusion, and the heavy weight of the canister. The results of safety analysis for the canister shows that the criticality for the normal case including uncertainty is the value of 0.816 which meets subcritical condition. Considering nation's 'Basic Plan for Electric Power Demand and Supply' and based on the scenario of disposing CANDU spent fuels in the first phase, the disposal system that the repository will be excavated in eight phases with the construction of the Underground Research Laboratory (URL) beginning in 2020 and commissioning in 2040 until the closure of the repository is proposed. Since there is close correlation between domestic HLW management plans and front-end/back-end fuel cycle plans causing such a great sensitivity of international environment factor, items related to assuring the non-proliferation and observing the international standard are showed to be the influential factor and acceptability

  5. Development of FAME Animation System

    Hasegawa, Yukihiro; Hamamatsu, Kiyotaka; Shirai, Hiroshi; Matsuda, Toshiaki [Department of Fusion Plasma Research, Naka Fusion Research Establishment, Japan Atomic Energy Research Institute, Naka, Ibaraki (Japan); Watanabe, Hideto; Itakura, Hirofumi; Tahata, Yasunori

    1999-02-01

    In order to monitor an animation of magnetohydrodynamic equilibrium calculated by the FAME-II (Fast Analyzer for Magnetohydrodynamic Equilibrium-II) system, a FAME Animation System was developed. This system provides automatically the animation on workstations connected to network with the same period of JT-60U discharge sequence. Then, the system can supply the important information for JT-60U operators to determine control parameters of the succeeding discharge. This report describes the overview of the FAME Animation System. (author)

  6. Information system development activities and inquiring systems

    Carugati, Andrea

    2008-01-01

    This article presents a framework that maps information system development (ISD) activities on systems for the creation of knowledge. This work addresses the relevant and persisting problem of improving the chances of ISD success. The article builds upon previous research on knowledge aspects of...... provides a new way to see the development of a system in terms of the knowledge created in the process. The main practical implication of the framework is that it improves the managers' ability to guide ISD activities as knowledge activities embedded in a knowledge process, a crucial element in development...... ISD, abandoning the idea of a monolithic approach to knowledge and presenting a pluralistic approach based on the idea that different inquiring systems can support micro-level ISD activities. The article is divided into two parts. The first part presents the theoretical development of the framework...

  7. The Guided System Development Framework

    Carvalho Quaresma, Jose Nuno; Probst, Christian W.; Nielson, Flemming

    The Service-Oriented Computing paradigm has had significant influence on the Internet. With the emergence of this paradigm, it is important to provide tools that help developers designing and verifying such systems. In this article, we present the Guided System Development (GSD) Framework that aids...

  8. Collaborative development of embedded systems

    Verhoef, Marcel; Pierce, Kenneth; Gamble, Carl; Broenink, Jan; Fitzgerald, John; Larsen, Peter Gorm; Verhoef, Marcel

    2014-01-01

    This chapter presents motivation for taking a collaborative multi-disciplinary approach to the model-based development of embedded systems. Starting from a consideration of the ubiquity of embedded systems in daily life it identifies challenges faced by industry in developing products in a timely ma

  9. Development of a multifunctional particle spectrometer for space radiation imaging

    For future exploration of the solar system, the European Space Agency (ESA) is planning missions to Mercury (BepiColombo), the Sun (SolarOrbiter) and to the moons of Jupiter and Saturn. The expected intensity of radiation during such missions is hazardous for the scientific instruments and the satellite. To extend the lifetime of the satellite and its payload a multifunctional particle spectrometer (MPS) is being developed. The basic function of the MPS is to send an alarm signal to the satellite control system during periods of high radiation. In addition the MPS is a scientific instrument that will unfold the composition of the different contributing particles on-line by the dE/dx versus E method. The energy spectrum and angular distribution of the particles will be recorded as well. This article describes the main requirements and the base line design for the MPS. A readout scheme consisting of a 32 channel ASIC from IDEAS is proposed and the signal filtering algorithm will run on a digital signal processor based on FPGA technology. Results are shown from prototype calibration studies with a proton beam

  10. ISE System Development Methodology Manual

    Hayhoe, G.F.

    1992-02-17

    The Information Systems Engineering (ISE) System Development Methodology Manual (SDM) is a framework of life cycle management guidelines that provide ISE personnel with direction, organization, consistency, and improved communication when developing and maintaining systems. These guide-lines were designed to allow ISE to build and deliver Total Quality products, and to meet the goals and requirements of the US Department of Energy (DOE), Westinghouse Savannah River Company, and Westinghouse Electric Corporation.

  11. Development of televoting information system

    Lesjak, Miran

    2008-01-01

    Purpose of this paper is to present an approach of developing a Televoting information system. The main goal of the system is to simplify management of televoting events and to assure fast and simple control over televoting events and statistics. In the first part we represent Adobe Flash technology, MySQL relational database management system, Typo3 Content Management System, PHP scripting language, Microsoft Visual Studio Studio 2008, C# programming language and Rational Rose (a too...

  12. Exercise tolerance test (ett) or myocardial perfusion scan (mps) - what to choose in patients of ischaemic heart disease (ihd)

    Objective: To evaluate the validity of exercise tolerance test (ETT) with treadmill exercise in the diagnosis and follow-up of ischaemic heart disease (IHD), taking myocardial perfusion scan (MPS) as standard. Study Design: Retrospective, validation study. Place and Duration of Study: Nuclear Medical Centre (NMC) Armed Forces Institute of Pathology (AFIP), Rawalpindi, Pakistan, from 1 January to 31 December 2009. Patients and Methods: One hundred and nineteen patients (88 males, 31 females), referred for MPS; were selected through non-probability, consecutive sampling. Patients of all ages and gender, fit to undertake treadmill exercise, were included. Patients with contraindications to ETT, like unstable angina, conduction abnormalities, etc., or those who had taken a beta blocker within the preceding 24 hours, were excluded. ETT through treadmill exercise was done, followed by MPS with single photon emission computed tomography (SPECT) technique, using Thallium-201 or Technetium-99 m 2-methoxy-isobutyl-isonitrile (MIBI). ETT was interpreted as positive or negative for ischaemia, with borderline changes considered positive. MPS was interpreted as positive or negative for ischaemia. Validity of ETT was evaluated in terms of sensitivity (Sn), specificity (Sp), and positive and negative predictive value (PPV and NPV), taking MPS as standard. Results: Sensitivity of ETT was found to be 77.5% and specificity was 43.6%. PPV was 73.8% and NPV was 48.6%. Out of a total (n) of 119 patients, true positive (TP) cases were 62, true negative (TN) 17, false positive (FP) 22 and false negative (FN) 18. Conclusions: ETT is an acceptably sensitive but non-specific test for evaluating myocardial ischaemia, with adequate PPV but low NPV, when validating it against MPS. Replacing the MPS with ETT, in the diagnosis and follow-up of IHD, is thus, not prudent. ETT can be useful as a screening test. (author)

  13. The safety of dipyridamole myocardial perfusion scintigraphy (MPS) in patients with end-stage chronic airways limitations (CAL)

    Full text: Dipyridamole MPS is a well-established investigative technique in the diagnosis and pre-operative risk stratification of patients with possible coronary artery disease. However, there remains a concern of its use in patients with end-stage chronic airways limitations (CAL). Lung volume reduction surgery (LVRS) is a recent therapeutic option for such patients. The options for non-invasive pre-operative cardiac assessment in such patients are limited. This study reviewed the safety of dipyridamole use in such a clinical setting. 20 patients (10M, 10F, mean age 64.8 yrs) were evaluated. None had any history of ischaemic heart disease. Dipyridamole was administered intravenously at a dose of 0.05 mg/kg. Six patients remained asymptomatic throughout the procedure, while none experienced any chest pain. Two patients experienced moderate dyspnoea, which was rapidly relieved with aminophylline (100mg IV) during the recovery phase of the study. Two others developed mild dyspnoea; one settled spontaneously, while the other responded promptly to aminophylline. Aminophylline was administered to nine other patients to reverse minor symptoms (headache, flushing sensation). One other patient developed marked hypotension (SBP fell >20mmHg) and bradycardia, but no ECG changes for myocardial ischaemia. He responded well to aminophylline. His myocardial perfusion scan demonstrated extensive reversible myocardial ischaemia. Although the population size was small, dipyridamole appears safe to use in patients with end-stage CAL. Copyright (2000) The Australian and New Zealand Society of Nuclear Medicine Inc

  14. Developing an Environmental Scanning System.

    Morrison, James L.

    A step-by-step approach is provided for developing an environmental scanning system for colleges and universities to assist them in planning for the future. The objectives of such a system are to detect social, scientific, economic, technical, and political interactions important to the organization; define potential threats and opportunities from…

  15. Development of Dictionary Writing System

    Barbierik, Kamil; Holcová Habrová, Martina; Jarý, Vladimír; Kochová, Pavla; Liška, Tomáš; Opavská, Zdeňka; Virius, Miroslav

    Jihlava: College of Polytechnics, 2013 - (Molhanec, M.; Bejček, M.; Voráček, J.), s. 133-147 ISBN 978-80-86847-66-5. [Federated conference on 39th Software Development and 17th Object Technologies (SDOT 2013). Jihlava (CZ), 08.11.2013] R&D Projects: GA MK DF13P01OVV011 Keywords : dictionary writing system * database system * lexicography Subject RIV: AI - Linguistics

  16. DEVELOPMENT OF VEHICLES RECYCLING SYSTEM

    PAWE£ SMOLNIK

    2014-01-01

    Fast development of automotive industry in Poland in recent years involves the need for rational waste management from the destruction and exploitation of vehicles. Rising number of new cars in Poland and existing age structure of the domestic park of vehicles will contribute to the increase number cars withdrawn from use. The way to solve the growing problem of waste recycling is the development of vehicles recycling system which contributes to the economic management of natural resources an...

  17. Mps1 and Ipl1/Aurora B Act Sequentially to Correctly Orient Chromosomes on the Meiotic Spindle of Budding Yeast

    Meyer, Régis E; Kim, Seoyoung; Obeso, David; Straight, Paul D.; Winey, Mark; Dawson, Dean S.

    2013-01-01

    The conserved kinases Mps1 and Ipl1/Aurora B are critical for enabling chromosomes to attach to microtubules such that partner chromosomes will be segregated correctly from each other, but the precise roles of these kinases have been unclear. Here, imaging of live yeast cells was performed to elucidate the stages of chromosome-microtubule interactions, and their regulation by Ipl1 and Mps1, through meiosis I. Ipl1 was found to release kinetochore-microtubule (kMT) associations following meiot...

  18. Development of Moving Particle Simulation Method for Multiliquid-Layer Sloshing

    Kyung Sung Kim

    2014-01-01

    Full Text Available The mixed oil and gas including water and sand are extracted from well to offshore structure. This mixed fluid must be separated for subsequent processes by using wash tanks or separators. To design such a system, a proper numerical-prediction tool for multiphase fluids is required. In this regard, a new moving particle simulation (MPS method is developed to simulate multiliquid-layer sloshing problems. The new MPS method for multifluid system includes extra search methods for interface particles, boundary conditions for interfaces, buoyancy-correction model, and surface-tension model for interface particles. The new particle interaction models are verified through comparisons with published numerical and experimental data. In particular, the multiliquid MPS method is verified against Molin et al’s (2012 experiment with three liquid layers. In case of excitation frequency close to one of the internal-layer resonances, the internal interface motions can be much greater than top free-surface motions. The verified multiliquid MPS program is subsequently used for more nonlinear cases including multichromatic multimodal motions with larger amplitudes, from which various nonlinear features, such as internal breaking and more particle detachment, can be observed. For the nonlinear case, the differences between with and without buoyancy-correction and surface-tension models are also demonstrated.

  19. Open quantum systems recent developments

    Joye, Alain; Pillet, Claude-Alain

    2006-01-01

    Understanding dissipative dynamics of open quantum systems remains a challenge in mathematical physics. This problem is relevant in various areas of fundamental and applied physics. From a mathematical point of view, it involves a large body of knowledge. Significant progress in the understanding of such systems has been made during the last decade. These books present in a self-contained way the mathematical theories involved in the modeling of such phenomena. They describe physically relevant models, develop their mathematical analysis and derive their physical implications. In Volume I the Hamiltonian description of quantum open systems is discussed. This includes an introduction to quantum statistical mechanics and its operator algebraic formulation, modular theory, spectral analysis and their applications to quantum dynamical systems. Volume II is dedicated to the Markovian formalism of classical and quantum open systems. A complete exposition of noise theory, Markov processes and stochastic differential...

  20. Overview of the control system for the IFMIF/EVEDA accelerator

    The accelerator for Engineering Validation and Engineering Design Activity (EVEDA) of International Fusion Materials Irradiation Facility (IFMIF) will produce 9 MeV/125 mA CW beam. The IFMIF/EVEDA accelerator consists of Injector, RFQ, the first section of SC HWR Linac, etc. The control system for the IFMIF/EVEDA accelerator consists of Personnel Protection System (PPS), Machine Protection System (MPS), Central Control System (CCS), Local Area Network (LAN), Timing System (TS) and Local Control System (LCS). The PPS, MPS, CCS, LAN and TS have been developed by JAEA, and the LCS has been charged by EU. For these JAEA tasks, the design scenario taking into account of radio-activation, the development status and the development schedule for each accelerator components (Injector, RFQ, SC HWR linac, RF system, etc.) are presented in details. (author)

  1. Copper vapor laser system development

    High-power, high-quality, and long-life copper vapor laser (CVL) system has been developed and operated. The system is composed of a small sized CVL oscillator with high beam quality, several high-power CVL amplifiers and related sub-systems such as special resonator optics, beam shaping and propagating optics, and pulse timing controller. Further developments of high-power amplifiers are being conducted for the next R and D targets. In our latest tests, the maximum output power of 480W has been achieved by optimizing discharge circuit conditions. Major-components life-time of more than 2000 hours has been also ensured in long-term CVL amplifier operation tests. Accumulated operation time of more than 700 hours has been achieved without refilling copper source or any maintenance. (author)

  2. Social networks, politics and Commitment 2.0: Spanish MPs on Facebook

    José Sixto, B.A.

    2011-01-01

    Full Text Available In a technologically and sociologically advanced society, the organizations that do not use the new media and the cyber communication techniques are probably doomed to failure. In this virtual sphere the social networks constitute a suitable resource and channel for the implementation of political marketing 2.0, as it provides a scenario where the interaction with users is possible. From this perspective, we verified their presence of the 350 members of the Spanish Congress on Facebook, the country’s most popular social network, in order to establish the predominant typologies, updating frequency, contents, resources, and the types of information posted in this spaces.This article also examines the interactivity of MPs in what we have termed Commitment 2.0: political communication in personal contexts such as social networks requires going from the participatory attitude to the participatory action; that is, to accept the interaction 2.0 as the correct behaviour on the network.

  3. Halon explosion protection system development

    A loss-of-coolant-accident in a water-cooled nuclear reactor could result in the accumulation of hydrogen and oxygen gases in the containment vessel, ignition of which might produce explosion pressures that exceed the containment design. Protection against suh a hazard can be provided by an inerting system which utilizes Halon 1301 (CF3Br). This inerting gas would be stored in the liquified state and injected only if needed. A development study is reported in which the quantity of Halon required for inerting has been measured, and several envisioned problems investigated. A sub-scale system has been fabicated and used to simulate operation of an actual system under post-LOCA conditions. The testing, together with a system analysis, indicates that the 1301 inerting concept is very suitable for containment application

  4. Networking systems design and development

    Chao, Lee

    2009-01-01

    Effectively integrating theory and hands-on practice, Networking Systems Design and Development provides students and IT professionals with the knowledge and skills needed to design, implement, and manage fully functioning network systems using readily available Linux networking tools. Recognizing that most students are beginners in the field of networking, the text provides step-by-step instruction for setting up a virtual lab environment at home. Grounded in real-world applications, this book provides the ideal blend of conceptual instruction and lab work to give students and IT professional

  5. Managing Sustainable Information Systems Development

    Kautz, Karlheinz

    2013-01-01

    Sustainable information systems development (ISD) in the context of this paper is not about products that support sustainability at large with its environmental, economic and social dimensions and little about the development of sustainable products, which are both without doubt important topics....... This paper is about a prerequisite for such products, namely, a sustainable ISD process, a process which exhibits reasonable and responsible stewardship and utilisation of the existing resources for ISD—people and information in the context of scope, time/schedule, budget/cost, quality and risk....

  6. Implementation of alarm system for vibration monitoring of KOMAC facility

    For operating 100 MeV linac, Devices have to be operated in certain order. Thus malfunction of a device cause damage to linac and related devices. To protect linac, machine protect system (MPS) has been developed. The MPS protects the components by monitoring hardwired signals. When values of operating parameters go beyond or below limit, alarm will be generated and interlock system which stops related devices in certain sequence will run. Other factor, giving damage to linac is disaster. A strong vibration such as earthquake causes malfunction of devices and damage to linac. Against disaster, the monitoring system based on Experimental Physics and Industrial Control System (EPICS) was implemented. Configuration and Implementation of the monitoring system are presented and some preliminary results are reported. KOMAC implemented alarm system for a strong vibration and fire. Alarm is generated in unusual situation. Coping rapidly with situation, damages for Linac and related devices can be reduced

  7. A Study on the Management of Micropollutants in Water System Considering Climate Change and other Potential Effects

    In this study, the management polices of micropollutants (MPs) were reviewed and the future management strategy was discussed considering climate change and etc. In Korea, the investigation of drinking water has been actively carried out for the priority contaminants as well as MPs. Recently river and lake waters have been also examined for MPs. However, the coverage and depth of the investigation is limited. Moreover, climate change is likely to increase air, water temperature and it will affect the hydrological cycle. Such changes may increase the residual concentrations of MPs in water system. As water reuse increases, the residual MPs of the recycled water may create public concerns. Thus, in a viewpoint of the precautionary principle, more stringent management of MPs is recommended for the drinking water and the body-contact water use. For the surface water, more studies are necessary to understand the ecological risk by MPs

  8. A Study on the Management of Micropollutants in Water System Considering Climate Change and other Potential Effects

    Kim, Hojeong; Ahn, Jong Ho [Korea Environment Institute (KEI), Seoul (Korea, Republic of); Hong, Yongsuk [Korea University, Sejong (Korea, Republic of)

    2013-12-15

    In this study, the management polices of micropollutants (MPs) were reviewed and the future management strategy was discussed considering climate change and etc. In Korea, the investigation of drinking water has been actively carried out for the priority contaminants as well as MPs. Recently river and lake waters have been also examined for MPs. However, the coverage and depth of the investigation is limited. Moreover, climate change is likely to increase air, water temperature and it will affect the hydrological cycle. Such changes may increase the residual concentrations of MPs in water system. As water reuse increases, the residual MPs of the recycled water may create public concerns. Thus, in a viewpoint of the precautionary principle, more stringent management of MPs is recommended for the drinking water and the body-contact water use. For the surface water, more studies are necessary to understand the ecological risk by MPs.

  9. ITER Plasma Control System Development

    Snipes, Joseph; ITER PCS Design Team

    2015-11-01

    The development of the ITER Plasma Control System (PCS) continues with the preliminary design phase for 1st plasma and early plasma operation in H/He up to Ip = 15 MA in L-mode. The design is being developed through a contract between the ITER Organization and a consortium of plasma control experts from EU and US fusion laboratories, which is expected to be completed in time for a design review at the end of 2016. This design phase concentrates on breakdown including early ECH power and magnetic control of the poloidal field null, plasma current, shape, and position. Basic kinetic control of the heating (ECH, ICH, NBI) and fueling systems is also included. Disruption prediction, mitigation, and maintaining stable operation are also included because of the high magnetic and kinetic stored energy present already for early plasma operation. Support functions for error field topology and equilibrium reconstruction are also required. All of the control functions also must be integrated into an architecture that will be capable of the required complexity of all ITER scenarios. A database is also being developed to collect and manage PCS functional requirements from operational scenarios that were defined in the Conceptual Design with links to proposed event handling strategies and control algorithms for initial basic control functions. A brief status of the PCS development will be presented together with a proposed schedule for design phases up to DT operation.

  10. Development of logistics information systems

    Milan Ž. Dronjak

    2012-10-01

    -Army (Global Combat Support System-Army Field/Tactical, is intended for the tactical level and it will replace 14 tactical logistics information systems and connect them with the rest of the information environment. Tendencies in the development of logistics information systems In line with the presented information solutions, it is possible to extract relevant conclusions about tendencies in the development of these types of systems all around the world. These conclusions should be implemented, through adequate principles, into domestic software development. Three main tendencies are visible in modern solutions: using centralised databases, integration of existing separated software solutions, and connecting previously autonomus systems. Conclusion In accordance with present time requirements, logistic support should be realised as close as possible to the origin of a logistic need, in real time and adequately. Information systems enable real time delivery of information needed for a quality logistic support in all phases of operations as well as for a faster generation of all types of documents.

  11. Reciprocating Feed System Development Status

    Trewek, Mary (Technical Monitor); Blackmon, James B.; Eddleman, David E.

    2005-01-01

    The reciprocating feed system (RFS) is an alternative means of providing high pressure propellant flow at low cost and system mass, with high fail-operational reliability. The RFS functions by storing the liquid propellants in large, low-pressure tanks and then expelling each propellant through two or three small, high-pressure tanks. Each RFS tank is sequentially filled, pressurized, expelled, vented, and refilled so as to provide a constant, or variable, mass flow rate to the engine. This type of system is much lighter than a conventional pressure fed system in part due to the greatly reduced amount of inert tank weight. The delivered payload for an RFS is superior to that of conventional pressure fed systems for conditions of high total impulse and it is competitive with turbopump systems, up to approximately 2000 psi. An advanced version of the RFS uses autogenous pressurization and thrust augmentation to achieve higher performance. In this version, the pressurization gases are combusted in a small engine, thus making the pressurization system, in effect, part of the propulsion system. The RFS appears to be much less expensive than a turbopump system, due to reduced research and development cost and hardware cost, since it is basically composed of small high- pressure tanks, a pressurization system, and control valves. A major benefit is the high reliability fail-operational mode; in the event of a failure in one of the three tank-systems, it can operate on the two remaining tanks. Other benefits include variable pressure and flow rates, ease of engine restart in micro-gravity, and enhanced propellant acquisition and control under adverse acceleration conditions. We present a system mass analysis tool that accepts user inputs for various design and mission parameters and calculates such output values payload and vehicle weights for the conventional pressure fed system, the RFS, the Autogenous Pressurization Thrust Augmentation (APTA) RFS, and turbopump systems

  12. KSTAR RF heating system development

    Kwak, J. G.; Kim, S. K.; Hwang, C. K. (and others)

    2007-10-15

    Design, high-voltage test, and installation of 6 MW ICRF heating system for KSTAR is completed. The antenna demonstrated satisfactory standoff at high voltages up to 41 kV for 300 sec. The result indicates good power handling capabilities of the antenna as high as 10 MW/m2. This power density is equivalent to RF power coupling of 6 MW into a 4 {omega}/m target plasma, and is typical of advanced tokamak heating scenarios. In addition, vacuum feed through, DC break, and liquid stub developed for 300 sec operation are installed, as well as a 2 MW, 30-60MHz transmitter. The transmitter successfully produced output powers of 600 kW continuously, 1.5{approx}1.8 MW for 300 sec, and 2 MW for 100 msec or shorter pulses. A realtime control system based on DSP and EPICS is developed, installed, and tested on the ICRF system. Initial results from feasibility study indicate that the present antenna and the transmission lines could allow load-resilient operation on KSTAR. Until the KSTAR tokamak start to produce plasmas in 2008, however, hands-on operational experiences are obtained from participating in ICRF heating experiments at ASDEX and DIII-D tokamaks arranged through international cooperation.

  13. Expert system development (ESD) shell

    An Expert System Development (ESD) Shell design implementation is desribed in detail. The shell provides high-level generic facilities for Knowledge Representation (KR) and inferencing and tools for developing user interfaces. Powerful set of tools in the shell relieves much of the programming burden in the ES development. The shell is written in PROLOG under IBM PC/AT. KR facilities are based on two very powerful formalisms namely, frames and rules. Inference Engine (IE) draws most of its power from unification and backward reasoning strategy in PROLOG. This basic mechanism is enhanced further by incorporating both forward and backward chaining of rules and frame-based inferencing. Overall programming style integrates multiple paradigms including logic, object oriented, access-oriented and imperative programming. This permits ES designer a lot of flexibility in organizing inference control. Creation and maintainance of knowledge base is a major activity. The shell, therefore, provides number of facilities to simplify these tasks. Shell design also takes note of the fact that final success of any system depends on end-user satisfaction and hence provides features to build use-friendly interfaces. The shell also provides a set of interfacing predicates so that it can be embedded within any PROLOG program to incorporate functionalilty of the shell in the user program. (author). 10 refs., 8 figs

  14. StaMPS Improvement for Deformation Analysis in Mountainous Regions: Implications for the Damavand Volcano and Mosha Fault in Alborz

    Sanaz Vajedian

    2015-06-01

    Full Text Available Interferometric Synthetic Aperture Radar (InSAR capability to detect slow deformation over terrain areas is limited by temporal decorrelation, geometric decorrelation and atmospheric artefacts. Multitemporal InSAR methods such as Persistent Scatterer (PS-InSAR and Small Baseline Subset (SBAS have been developed to deal with various aspects of decorrelation and atmospheric problems affecting InSAR observations. Nevertheless, the applicability of both PS-InSAR and SBAS in mountainous regions is still challenging. Correct phase unwrapping in both methods is hampered due to geometric decorrelation in particular when using C-band SAR data for deformation analysis. In this paper, we build upon the SBAS method implemented in StaMPS software and improved the technique, here called ISBAS, to assess tectonic and volcanic deformation in the center of the Alborz Mountains in Iran using both Envisat and ALOS SAR data. We modify several aspects within the chain of the processing including: filtering prior to phase unwrapping, topographic correction within three-dimensional phase unwrapping, reducing the atmospheric noise with the help of additional GPS data, and removing the ramp caused by ionosphere turbulence and/or orbit errors to better estimate crustal deformation in this tectonically active region. Topographic correction is done within the three-dimensional unwrapping in order to improve the phase unwrapping process, which is in contrast to previous methods in which DEM error is estimated before/after phase unwrapping. Our experiments show that our improved SBAS approach is able to better characterize the tectonic and volcanic deformation in the center of the Alborz region than the classical SBAS. In particular, Damavand volcano shows an average uplift rate of about 3 mm/year in the year 2003–2010. The Mosha fault illustrates left-lateral motion that could be explained with a fault that is locked up to 17–18 km depths and slips with 2–4 mm

  15. Development of targeted radiotherapy systems

    Conventional or external beam radiotherapy, has been a viable alternative for cancer treatment. Although this technique is effective, its use is limited if the patient has multiple malignant lesions (metastases). An alternative approach is based on the design of radiopharmaceuticals that, to be administered in the patient, are directed specifically toward the target cell producing a selective radiation delivery. This treatment is known as targeted radiotherapy. We have summarized and discussed some results related to our investigations on the development of targeted radiotherapy systems, including aspects of internal dosimetry

  16. Computer aided training system development

    The first three phases of Training System Development (TSD) -- job and task analysis, curriculum design, and training material development -- are time consuming and labor intensive. The use of personal computers with a combination of commercial and custom-designed software resulted in a significant reduction in the man-hours required to complete these phases for a Health Physics Technician Training Program at a nuclear power station. This paper reports that each step in the training program project involved the use of personal computers: job survey data were compiled with a statistical package, task analysis was performed with custom software designed to interface with a commercial database management program. Job Performance Measures (tests) were generated by a custom program from data in the task analysis database, and training materials were drafted, edited, and produced using commercial word processing software

  17. The Simulator of the Timing and Magnitude of Pollen Season (STaMPS model: a pollen production model for regional emission and transport modeling

    T. R. Duhl

    2013-04-01

    Full Text Available A pollen model that simulates the timing and production of wind-dispersed allergenic pollen by terrestrial, temperate vegetation has been developed to quantify how pollen occurrence may be affected by climate change and to investigate how pollen can interact with anthropogenic pollutants to affect human health. The Simulator of the Timing and Magnitude of Pollen Season (STaMPS model is driven by local meteorological conditions and is designed to be sensitive to climate shifts, as well as flexible with respect to the vegetation species and plant functional types (trees, grasses, etc. represented and the climate zones simulated. The initial focus for the model is the simulation of the pollen emission potential of important allergenic tree and grass species that typically flower between March–June in Southern California (S. CA, which is characterized by moderate Mediterranean and oceanic climate zones as well as regions of arid desert and arid steppe. Vegetation cover and species composition data are obtained from numerous datasets and a database of allergenic vegetation species, their pollen production potential and relative allergenicities has been developed. For the selected allergenic species and spring-early summer simulation period, temperature is the main driver controlling the timing of pollen release, while precipitation (and temperature, for some species controls the magnitude of pollen produced. The model provides species-specific pollen potential maps for each day of the simulation period; these are then used by a pollen transport model to simulate ambient pollen concentrations as described in a companion paper (Zhang et al., 2013a, which also presents model evaluation results for the S. CA model domain. The STaMPS model was also used to quantify the possible impact of climate change on pollen season under the IPCC SRES A1B scenario as simulated by the ECHAM5 global climate model. Current (1995–2004 and future (2045–2054

  18. ADASAGE, ADA Application Development System

    1 - Description of program or function: ADASAGE is an application development system designed to facilitate rapid and professional construction of applications written in Ada on microcomputers. ADASAGE applications may vary in size from small to large multi-program systems. ADASAGE consists of a collection of re-usable libraries for database management and form and report processing utilities having the following capabilities: basic universal type and function definitions; sequential file input/output; terminal and file input/output; DOS system command execution; data movement and fill; string manipulation; math libraries; bit manipulation; a relational database utility; data validation; menu form and window procedures; report generation; sort/merge, time, and date functions; sound production; editing; and index rebuilding. Each of the capabilities is integrated to allow the development of an efficient system. As an application is designed and developed, the desired ADASAGE capabilities are chosen and included along with any requirements unique to that application. 2 - Method of solution: All ADASAGE applications which use the database, forms (windows, menus, etc.), or reporting functions require a file with a suffix of .DFL. This file contains the database schema, the various forms and windows, and report definitions. The THOR editor is used to create and maintain the .DFL file. This editor operates on a file with the suffix .SRC and creates and edits schemes, forms, and report formats and compile the .SRC file into the .DFL file used by the application. The application will have unique requirements not satisfied by the selected utilities of ADASAGE. The code for these along with the code necessary to import and use the selected ADASAGE utilities constitutes the programmed application. The completed application system will contain the .DFL file produced by the THOR editor, the required ADASAGE utilities, and the programmed application. During the course of normal

  19. Characterization of the MPS I-H knock-in mouse reveals increased femoral biomechanical integrity with compromised material strength and altered bone geometry

    Arin K. Oestreich

    2015-12-01

    Full Text Available Mucopolysaccharidosis type I (MPS I, is an autosomal recessive lysosomal storage disorder caused by a deficiency in the α-L-iduronidase enzyme, resulting in decreased enzymatic activity and accumulation of glycosaminoglycans. The disorder phenotypically manifests with increased urine glycosaminoglycan excretion, facial dysmorphology, neuropathology, cardiac manifestations, and bone deformities. While the development of new treatment strategies have shown promise in attenuating many symptoms associated with the disorder, the bone phenotype remains unresponsive. The aim of this study was to investigate and further characterize the skeletal manifestations of the Idua-W392X knock-in mouse model, which carries a nonsense mutation corresponding to the IDUA-W402X mutation found in Hurler syndrome (MPS I-H patients. μCT analysis of the microarchitecture demonstrated increased cortical thickness, trabecular number, and trabecular connectivity along with decreased trabecular separation in the tibiae of female homozygous Idua-W392X knock-in (IDUA−/− mice, and increased cortical thickness in male IDUA−/− tibiae. Cortical density, as determined by μCT, and bone mineral density distribution, as determined by quantitative backscattered microscopy, were equivalent in IDUA−/− and wildtype (Wt bone. However, tibial porosity was increased in IDUA−/− cortical bone. Raman spectroscopy results indicated that tibiae from female IDUA−/− had decreased phosphate to matrix ratios and increased carbonate to phosphate ratios compared to Wt female tibiae, whereas these ratios remained equivalent in male IDUA−/− and Wt tibiae. Femora demonstrated altered geometry and upon torsional loading to failure analysis, female IDUA−/− mouse femora exhibited increased torsional ultimate strength, with a decrease in material strength relative to Wt littermates. Taken together, these findings suggest that the IDUA−/− mutation results in increased bone

  20. Space Launch System Development Status

    Lyles, Garry

    2014-01-01

    Development of NASA's Space Launch System (SLS) heavy lift rocket is shifting from the formulation phase into the implementation phase in 2014, a little more than three years after formal program approval. Current development is focused on delivering a vehicle capable of launching 70 metric tons (t) into low Earth orbit. This "Block 1" configuration will launch the Orion Multi-Purpose Crew Vehicle (MPCV) on its first autonomous flight beyond the Moon and back in December 2017, followed by its first crewed flight in 2021. SLS can evolve to a130-t lift capability and serve as a baseline for numerous robotic and human missions ranging from a Mars sample return to delivering the first astronauts to explore another planet. Benefits associated with its unprecedented mass and volume include reduced trip times and simplified payload design. Every SLS element achieved significant, tangible progress over the past year. Among the Program's many accomplishments are: manufacture of Core Stage test panels; testing of Solid Rocket Booster development hardware including thrust vector controls and avionics; planning for testing the RS-25 Core Stage engine; and more than 4,000 wind tunnel runs to refine vehicle configuration, trajectory, and guidance. The Program shipped its first flight hardware - the Multi-Purpose Crew Vehicle Stage Adapter (MSA) - to the United Launch Alliance for integration with the Delta IV heavy rocket that will launch an Orion test article in 2014 from NASA's Kennedy Space Center. Objectives of this Earth-orbit flight include validating the performance of Orion's heat shield and the MSA design, which will be manufactured again for SLS missions to deep space. The Program successfully completed Preliminary Design Review in 2013 and Key Decision Point C in early 2014. NASA has authorized the Program to move forward to Critical Design Review, scheduled for 2015 and a December 2017 first launch. The Program's success to date is due to prudent use of proven

  1. Magnetic properties and specific heat of MPS3 (M=Mn, Fe, Zn)

    The magnetic properties and specific heat of MPS3 (M=Mn, Fe and Zn) have been investigated. While ZnPS3 is non-magnetic, MnPS3 and FePS3 are antiferromagnets with the Neel temperature TN of 78 and 118 K, respectively. Nevertheless, the specific heat of MnPS3 and FePS3 is smaller than that of ZnPS3 below about 20 K. The temperature dependence of the magnetic specific heat CM of MnPS3 shows a broad hump which is characteristic to the two dimensional magnetic materials and a small sharp peak at TN. On the other hand, that of FePS3 shows a large sharp peak at TN. As for FePS3, the temperature dependences of the magnetization M and CM are well reproduced by taking account of the magneto-elastic effect which introduces an additional term proportional to the square of the average value of the spin to the exchange coupling constant. As for MnPS3, marked two dimensional characters appear in the temperature dependence of M and CM. The observed TN is much smaller than the paramagnetic Curie temperature of 240 K obtained from the temperature dependence of the magnetic susceptibility at high temperature

  2. Mycoplasma pneumonia of swine (MPS) resistance and immune characteristics of pig lines generated by crossing an MPS pulmonary lesion selected Landrace line and a highly immune capacity selected Large White line.

    Borjigin, Liushiqi; Shimazu, Tomoyuki; Katayama, Yuki; Watanabe, Kouichi; Kitazawa, Haruki; Roh, Sang-Gun; Aso, Hisashi; Katoh, Kazuo; Uchida, Takafumi; Suda, Yoshihito; Sakuma, Akiko; Nakajo, Mituru; Suzuki, Keiichi

    2016-08-01

    To understand the influence of crossbreeding on Mycoplasma pneumonia of swine (MPS) resistance and immune characteristics, two crossbred lines were characterized. One crossbred line, LaWa, was generated by crossing the MPS pulmonary lesion selected Landrace line (La) and the highly immune-selected Large White line (Wa). The second crossbred line, LaWb, was generated by crossing the La line and the nonselected Large White line (Wb). The crossbred LbWb line (nonselected Landrace line × nonselected Large White line) and the La line were used as controls. The LaWa and LaWb lines had an intermediate level of MPS lung lesions between La and LbWb lines, although the difference was not statistically significant. After stimulation with sheep red blood cells (SRBCs), the LaWb and LaWa lines showed immune characteristics similar to that of the La line; the number of monocytes in peripheral blood increased, while B cells, T cells, secretion of SRBC-specific immunoglobulin G, and interleukin (IL)-13 decreased. Additionally, the number of natural killer (NK) cells and the expression of IL-4 and IL-17 were significantly higher in the LaWb and LaWa lines, respectively. These data suggested that crossbreeding of La and Wa lines resulted in the inheritance of some of the selected immune responses. PMID:26709243

  3. Developing a Carbon Observing System

    Moore, B., III

    2015-12-01

    There is a clear need to better understand and predict future climate change, so that science can more confidently inform climate policy, including adaptation planning and future mitigation strategies. Understanding carbon cycle feedbacks, and the relationship between emissions (fossil and land use) and the resulting atmospheric carbon dioxide (CO2) and methane (CH4) concentrations in a changing climate has been recognized as an important goal by the IPCC. The existing surface greenhouse gas observing networks provide accurate and precise measurements of background values, but they are not configured to target the extended, complex and dynamic regions of the carbon budget. Space Agencies around the globe are committed to CO2 and CH4 observations: GOSAT-1/2, OCO-2/3, MERLin, TanSat, and CarbonSat. In addition to these Low Earth Orbit (LEO) missions, a new mission in Geostationary Orbit (GEO), geoCARB, which would provide mapping-like measurements of carbon dioxide, methane, and carbon monoxide concentrations over major land areas, has been recently proposed to the NASA Venture Program. These pioneering missions do not provide the spatial/temporal coverage to answer the key carbon-climate questions at process relevant scales nor do they address the distribution and quantification of anthropogenic sources at urban scales. They do demonstrate, however, that a well-planned future system of system integrating space-based LEO and GEO missions with extensive in situ observations could provide the accuracy, spatial resolution, and coverage needed to address critical open issues in the carbon-climate system. Dr. Diana Wickland devoted enormous energy in developing a comprehensive apprioach to understand the global carbon cycle; she understood well that an integrated, coordinated, international approach is needed. This shines through in her recent contribution in co-chairing the team that produced the "CEOS Strategy for Carbon Observations from Space." A NASA-funded community

  4. Common N-acetylgalactosamine-6-sulfate sulfatase (GALNS exon mutations in Brazilian patients with mucopolysaccharidosis IVA (MPS IVA

    Tatiana Dieter

    2007-01-01

    Full Text Available Morquio A Syndrome (mucopolysaccharidosis IVA - MPS IVA, OMIM# 253000 is an autosomal recessive inborn error of metabolism caused by the deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS. We investigated five unrelated Brazilian MPS IVA families for mutations in exons 4, 5, 9 and 10 of the GALNS gene. Six out of the 10 mutant alleles were identified. Taken together with a previous study, which included six unrelated families, common mutations among Brazilian patients were p.N164T, p.G116S and p.G301C. Among one hundred control subjects three novel silent mutations were found (p.A107A; GCC -> GCT, p.Y108Y; TAC -> TAT, p.P357P; CCG -> CCA. Screening starting with exons 4, 5, 9, 10 and 11 may be a good strategy for genotyping of Brazilian patients since these exons include 73% of all mutations identified in the current and previous studies.

  5. Growth of MPS-capped ZnS quantum dots in self-assembled thin films: Influence of heat treatment

    Koç, Kenan; Tepehan, Fatma Zehra; Tepehan, Galip Gültekin

    2015-12-01

    The colloidal ZnS quantum dots (QDs) were prepared using 3-mercaptopropyltrimethoxysilane (MPS) molecules. Sol-gel spin coating method was used to deposit the colloidal nanoparticles on a glass substrate. Several features of the MPS were made use to produce self assembled thin films of ZnS quantum dots in a SiO2 network. Produced films were heat treated in between 225 °C and 325 °C to investigate their growth kinetics. The result showed that their size changed approximately from 3 nm to 4 nm and the first excitation peak position changed from 4.6 eV to 4.1 eV in this temperature interval. The activation energy of the nanoparticles for the Ostwald ripening process was found to be 59 kJ/mol.

  6. Systems biology study of mucopolysaccharidosis using a human metabolic reconstruction network.

    Salazar, Diego A; Rodríguez-López, Alexander; Herreño, Angélica; Barbosa, Hector; Herrera, Juliana; Ardila, Andrea; Barreto, George E; González, Janneth; Alméciga-Díaz, Carlos J

    2016-02-01

    Mucopolysaccharidosis (MPS) is a group of lysosomal storage diseases (LSD), characterized by the deficiency of a lysosomal enzyme responsible for the degradation of glycosaminoglycans (GAG). This deficiency leads to the lysosomal accumulation of partially degraded GAG. Nevertheless, deficiency of a single lysosomal enzyme has been associated with impairment in other cell mechanism, such as apoptosis and redox balance. Although GAG analysis represents the main biomarker for MPS diagnosis, it has several limitations that can lead to a misdiagnosis, whereby the identification of new biomarkers represents an important issue for MPS. In this study, we used a system biology approach, through the use of a genome-scale human metabolic reconstruction to understand the effect of metabolism alterations in cell homeostasis and to identify potential new biomarkers in MPS. In-silico MPS models were generated by silencing of MPS-related enzymes, and were analyzed through a flux balance and variability analysis. We found that MPS models used approximately 2286 reactions to satisfy the objective function. Impaired reactions were mainly involved in cellular respiration, mitochondrial process, amino acid and lipid metabolism, and ion exchange. Metabolic changes were similar for MPS I and II, and MPS III A to C; while the remaining MPS showed unique metabolic profiles. Eight and thirteen potential high-confidence biomarkers were identified for MPS IVB and VII, respectively, which were associated with the secondary pathologic process of LSD. In vivo evaluation of predicted intermediate confidence biomarkers (β-hexosaminidase and β-glucoronidase) for MPS IVA and VI correlated with the in-silico prediction. These results show the potential of a computational human metabolic reconstruction to understand the molecular mechanisms this group of diseases, which can be used to identify new biomarkers for MPS. PMID:26276570

  7. Project management for information system development

    Zhang, Yang

    2011-01-01

    Nowadays, with the development of the information and communication technology, information systems have been developing rapidly. More and more software companies choose to develop the information system to be their main business. They want to increase their business profits by developing the information system. However, the failure rate of developing information system has been high during these years. The purpose of the thesis is to discover how to use project management knowledge to improv...

  8. Development of autonomous operation system

    To enhance operation reliability of nuclear plants by removing human factors, study on an autonomous operation system has been carried out to substitute artificial intelligence (AI) for plant operators and, in addition, traditional controllers used in existing plants. For construction of the AI system, structurization of knowledge on the basis of the principles such as physical laws, function and structure of relevant objects and generalization of problem solving process are intended. A hierarchical distributed cooperative system configuration in employed because it is superior from the viewpoint of dynamical reorganization of system functions. This configuration is realized by an object-oriented multi-agent system. Construction of a prototype system was planned and the conceptual design was made for FBR plant in order to evaluate applicability of AI to the autonomous operation and to have a prospect for the realization of the system. The prototype system executes diagnosis, state evaluation, operation and control for the main plant subsystems. (author)

  9. Embedded Automotive System Development Process

    Langenwalter, Joachim

    2005-01-01

    Model based design enables the automatic generation of final-build software from models for high-volume automotive embedded systems. This paper presents a framework of processes, methods and tools for the design of automotive embedded systems. A steer-by-wire system serves as an example.

  10. Sample preparation of membrane proteins suitable for solid-state MAS NMR and development of assignment strategies

    Hiller, Matthias

    2009-01-01

    Although the basic structure of biological membranes is provided by the lipid bilayer, most of the specific functions are carried out by membrane proteins (MPs) such as channels, ion-pumps and receptors. Additionally, it is known, that mutations in MPs are directly or indirectly involved in many diseases. Thus, structure determination of MPs is of major interest not only in structural biology but also in pharmacology, especially for drug development. Advances in structural biology of membrane...

  11. First human treatment with investigational rhGUS enzyme replacement therapy in an advanced stage MPS VII patient.

    Fox, Joyce E; Volpe, Linda; Bullaro, Josephine; Kakkis, Emil D; Sly, William S

    2015-02-01

    Mucopolysaccharidosis type VII (MPS VII, Sly syndrome) is a very rare lysosomal storage disease caused by a deficiency of the enzyme β-glucuronidase (GUS), which is required for the degradation of three glycosaminoglycans (GAGs): dermatan sulfate, heparan sulfate, and chondroitin sulfate. Progressive accumulation of these GAGs in lysosomes leads to increasing dysfunction in numerous tissues and organs. Enzyme replacement therapy (ERT) has been used successfully for other MPS disorders, but there is no approved treatment for MPS VII. Here we describe the first human treatment with recombinant human GUS (rhGUS), an investigational therapy for MPS VII, in a 12-year old boy with advanced stage MPS VII. Despite a tracheostomy, nocturnal continuous positive airway pressure, and oxygen therapy, significant pulmonary restriction and obstruction led to oxygen dependence and end-tidal carbon dioxide (ETCO2) levels in the 60-80mmHg range, eventually approaching respiratory failure (ETCO2 of 100mmHg) and the need for full-time ventilation. Since no additional medical measures could improve his function, we implemented experimental ERT by infusing rhGUS at 2mg/kg over 4h every 2 weeks for 24 weeks. Safety was evaluated by standard assessments and observance for any infusion associated reactions (IARs). Urinary GAG (uGAG) levels, pulmonary function, oxygen dependence, CO2 levels, cardiac valve function, liver and spleen size, and growth velocity were assessed to evaluate response to therapy. rhGUS infusions were well tolerated. No serious adverse events (SAEs) or IARs were observed. After initiation of rhGUS infusions, the patient's uGAG excretion decreased by more than 50%. Liver and spleen size were reduced within 2 weeks of the first infusion and reached normal size by 24 weeks. Pulmonary function appeared to improve during the course of treatment based on reduced changes in ETCO2 after off-ventilator challenges and a reduced oxygen requirement. The patient regained the

  12. Therapeutic Efficacy of Bone Marrow Transplant, Intracranial AAV-mediated Gene Therapy, or Both in the Mouse Model of MPS IIIB

    Heldermon, Coy D.; Ohlemiller, Kevin K.; Herzog, Erik D.; Vogler, Carole; Qin, Elizabeth; Wozniak, David F.; Tan, Yun; John L Orrock; Sands, Mark S.

    2010-01-01

    Sanfilippo syndrome type B (MPS IIIB) is a lysosomal storage disease resulting from a deficiency of N-acetyl-glucosaminidase (NAGLU) activity. In an attempt to correct the disease in the murine model of MPS IIIB, neonatal mice were treated with intracranial AAV2/5-NAGLU (AAV), syngeneic bone marrow transplant (BMT), or both (AAV/BMT). All treatments resulted in some improvement in clinical phenotype. Adeno-associated viral (AAV) treatment resulted in improvements in lifespan, motor function, ...

  13. Electro-Optic System Development Lab

    Federal Laboratory Consortium — The Electro-Optic System Development Lab serves as a development facility for electro-optical systems ranging from visible through long wave infrared. Capabilities...

  14. Risk management and expert system development methodology

    Hull, Larry; Gilstrap, Lewey

    1991-01-01

    A risk-based expert-system development methodology has been developed to provide guidance to managers and technical personnel and to serve as a standard for developing expert systems. Expert-system development differs from conventional software development in that the information needed to prepare system requirements for expert systems is not known at the outset of a project and is obtained by knowledge engineering methods. The paper describes the expert-system life cycle, development methodology, and the approach taken in this methodology to manage and reduce the risks in expert system development. Also examined are the risks of using and of not using a methodology, the studies undertaken to validate the provisions of the expert system development methodology, and the results of these validation studies.

  15. APPROACHING DEVELOPMENT IN LOGISTIC INFORMATION SYSTEMS

    Louis F Buys

    2012-01-01

    Full Text Available The introduction of technology into modern defence necessitates integrated computerized information systems to render effective and efficient logistic support. Traditional information system development does not ensure attainment of use and time scale requirements in the continuously developing environment of logistics. This paper describes current approaches to the development of logistic information systems.

  16. Integrating automated verification into interactive systems development

    Campos, J. Creissac

    1998-01-01

    Our field of research is the application of automated reasoning techniques during interactor based interactive systems development. The aim being to ensure that the developed systems embody appropriate properties and principles. In this report we identify some of the pitfalls of current approaches and propose a new way to integrate verification into interactive systems development.

  17. Developing Information Systems for Competitive Intelligence Support.

    Hohhof, Bonnie

    1994-01-01

    Discusses issues connected with developing information systems for competitive intelligence support; defines the elements of an effective competitive information system; and summarizes issues affecting system design and implementation. Highlights include intelligence information; information needs; information sources; decision making; and…

  18. MEASUREMENT PROCESS OF SOFTWARE DEVELOPMENT PROJECTS FOR SUPPORTING STRATEGIC BUSINESS OBJECTIVES IN SOFTWARE DEVELOPING COMPANIES

    Sandra Lais Pedroso

    2013-08-01

    Full Text Available Software developing companies work in a competitive market and are often challenged to make business decisions with impact on competitiveness. Models accessing maturity for software development processes quality, such as CMMI and MPS-BR, comprise process measurements systems (PMS. However, these models are not necessarily suitable to support business decisions, neither to achieve strategic goals. The objective of this work is to analyze how the PMS of software development projects could support business strategies for software developing companies. Results taken from this work show that PMS results from maturity models for software processes can be suited to help evaluating operating capabilities and supporting strategic business decisions.

  19. Restructure Staff Development for Systemic Change

    Kelly, Thomas F.

    2012-01-01

    This paper presents a systems approach based on the work of W. Edwards Deming to system wide, high impact staff development. Deming has pointed out the significance of structure in systems. By restructuring the process of staff development we can bring about cost effective improvement of the whole system. We can improve student achievement while…

  20. Product/Service-System Development

    Tan, Adrian; McAloone, Timothy Charles; Gall, Catherine

    2007-01-01

    in the design and development aspects of PSS. The objective of this paper is to explore how a global manufacturing company is developing an offering to their customers that is focused on the utility of their products throughout their life time. The paper describes the process of how a company is shifting from...... of their products. This process of re-defining the value of what the company is actually offering to its customers is seen as a key element in PSS development. PSS development is expected to expand conventional product development in new directions, such as new activities, roles and responsibilities, knowledge...... and competencies, and value network relationships. The implications of this are discussed in relation to the company’s development approach....

  1. Flexible Developing System for Modern Instrument Manufacturing

    2008-01-01

    The modern instrument manufacturing has many features, such as high technologies, multiple varieties and small quantities. Aiming at those features, an instrumentation flexible developing system (IFDS) is presented. It constitutes a kind of opening, compatible, extensible and upgradeable flexible developing system, and it will offer a kind of technology equipment for the research and development of new modern instrument products. Its flexible mechanism is able to be suited for different and special requirements of many instrument systems, and its system integrated mechanism is able to adapt to common technological features of most instrument systems. It is IFDS that makes it easy to accomplish a quick system integration of instrument products. IFDS solves key technological problems related to modern instruments development, develops multiple systems for modern instrument development and accomplishes rapid development of series of new products.

  2. Usability Factors in Information Systems Development

    K. Chandra Sekharaiah; A. Radha Krishna

    2014-01-01

    Computers have become a commonplace technology for today’s man. Computer users demand more reliable and durable interfaces from information processing applications developers. Information systems (ISs) research and development, over the years, has been steady so well that the arena has now grown into various subfields such as Cognitive Information Systems (CISs), Web Information Systems(WISs), Geographical Information Systems(GISs), Enterprise Information Systems (EISs), and so...

  3. A View of Earth System Model Development

    ZHOU Tianjun; YU Yongqiang; WANG Bin

    2009-01-01

    This paper gives a definition of earth system model and shows three development phases of it, including physical climate system model, earth climate system model, and earth system model, based on an inves-tigation of climate system models in the world. It provides an expatiation on the strategic significance of future development of earth system model, an introduction of some representative scientific research plans on development of earth system model home and abroad, and a review of its status and trends based on the models of the fourth assessment report (AR4) of the Intergovernmental Panel on Climate Change (IPCC).Some suggestions on future development of earth system model in China are given, which are expected to be helpful to advance the development.

  4. Development of Baby-EBM Interface System

    This paper explains the works being done to develop an interface system for Baby-Electron Beam Machine (EBM). The function of the system is for the safety, controlling and monitoring the Baby-EBM. The integration for the system is using data acquisition (DAQ) hardware and LabVIEW to develop the software. (author)

  5. X2000 power system electronics development

    Carr, Greg; Deligiannis, Frank; Franco, Lauro; Jones, Loren; Lam, Barbara; Nelson, Ron; Pantaleon, Jose; Ruiz, Ian; Treichler, John; Wester, Gene; Sauers, Jim; Giampoli, Paul; Haskell, Russ; Mulvey, Jim; Repp, John

    2005-01-01

    The X2000 Power System Electronics (PSE) is a Jet Propulsion Laboratory (JPL) task to develop a new generation of power system building blocks for potential use on future deep space missions. The effort includes the development of electronic components and modules that can be used as building blocks in the design of generic spacecraft power systems.

  6. Developing multiagent systems: the Gaia Methodology

    Zambonelli, F.; Jennings, N.R.; Wooldridge, M.

    2003-01-01

    Systems composed of interacting autonomous agents offer a promising software engineering approach for developing applications in complex domains. However, this multiagent system paradigm introduces a number of new abstractions and design/development issues when compared with more traditional approaches to software development. Accordingly, new analysis and design methodologies, as well as new tools, are needed to effectively engineer such systems. Against this background, the contribution of ...

  7. Computer system design environment software development plan

    Ross, Alan A.; Bowers, Jeanne

    1983-01-01

    The Computer Systems Design Environment (CSDE) project is an attempt at automated design of computer systems. The project develops a system which will accept functional statements of requirements from the designer (utilizing a user-friendly dialogue); translate those requirements into software and hardware primitives; evaluate those primitives and develop a proposed system using a Library of Realization Volumes. The CSDE will also verify that timing requirements have been met by the proposed ...

  8. The Guided System Development Framework: Modeling and Verifying Communication Systems

    Carvalho Quaresma, Jose Nuno; Probst, Christian W.; Nielson, Flemming

    2014-01-01

    . The Guided System Development framework contributes to more secure communication systems by aiding the development of such systems. The framework features a simple modelling language, step-wise refinement from models to implementation, interfaces to security verification tools, and code generation...

  9. Mobile Application Development: Component Retrieval System Project

    National Aeronautics and Space Administration — The proposed technology development concept is a software application tool developed for use on a mobile device at SSC for use in the component retrieval system...

  10. Model Driven Development of Data Sensitive Systems

    Olsen, Petur

    2014-01-01

    storage systems, where the actual values of the data is not relevant for the behavior of the system. For many systems the values are important. For instance the control flow of the system can be dependent on the input values. We call this type of system data sensitive, as the execution is sensitive to the...... values of variables. This theses strives to improve model-driven development of such data-sensitive systems. This is done by addressing three research questions. In the first we combine state-based modeling and abstract interpretation, in order to ease modeling of data-sensitive systems, while allowing...... efficient model-checking and model-based testing. In the second we develop automatic abstraction learning used together with model learning, in order to allow fully automatic learning of data-sensitive systems to allow learning of larger systems. In the third we develop an approach for modeling and model-based...

  11. Risks in Information Systems Development Projects

    Lazar Raković; Ozren Đurković

    2009-01-01

    Risk is a part of all aspects of everyday life. Development of an informational system is a complex process, which makes it submissive to a great number of risks. Many projects do not achieve previously set goals, therefore risk management is not to be ignored in the development of informational systems. In this paper, the efficacy of IS development, as well as a number of risks influencing the project development, are considered. Also, attention is paid to the risk management methodology, si...

  12. Autonomous Systems Developments and Trends

    Kyamaky, Kyandoghere; Kacprzyk, Janusz

    2012-01-01

    The Workshops on Autonomous Systems emanated from a gathering with the doctoral students of just three chairs at Fernuniversität in Hagen, which we organise twice per year for a number of years now. Their purpose is to discuss on-going research and to create a community spirit. Furthermore, they serve as a means of structuring the students' research processes. The workshop has grown and matured in several respects. The doctoral students presenting their work do not come from a single university anymore, but from three. Besides them and their supervisors, also other scientists became interested in the event and contribute to its programme. Following the model of Advanced Study Institutes, they are available on the premises for relaxed, informal discussions outside the formal sessions. Finally, with the co-sponsorship of Gesellschaft für Informatik, the German Computer Society, and this surprisingly comprehensive volume of contributions published by Springer-Verlag the workshop turned into a visible scientifi...

  13. Measurement of radioactivity by microplate-radioluminography. Development of microplate-evaporator

    A simple device for evaporating the sample solutions in 48 well-microplates (MP) was developed in order to facilitate the application of MP-radioluminography (RLG). The proposed device makes it possible to dry-up six MPs containing 0.2 ml water in each well within 1.5 h at one time. The MPs were placed overnight in a desiccator. The cross radioactive contamination accompanied with the evaporation process was not detected. A slight increase in the background photo-stimulated luminescence (PSL) value that was observed in the wells adjacent a radiation well could be attributed to a flare caused during analysis by a bio-imaging analyzer system (BAS). The detection limit of the MP-RLG was 0.05 Bq14C, when the evaporated MP was brought into contact with an imaging plate for 72 h and analyzed by a BAS. (author)

  14. Safeguards -Safeguards system development support-

    This project mainly focused to technically support national safeguards inspection which is scheduled in the beginning of 1997. It includes non-destructive assay of nuclear fuels, analysis on inspection and environmental samples, remote monitoring of nuclear activities and its analysis, survey on remote sensing of satellite for safeguards application. Non-destructive assay of nuclear fuels dealt with development on verification of spent fuels with emphasis to fabrication of inspection tools with surveillance and gamma measurement on CANDU spent fuels. For sample analysis, study was carried out on process inspection sample analysis method. In addition to this, ultra low background laboratory was set up to execute environmental and swipe samples and sample treatment techniques including water, soil, plant, et al. were researched. Tritiums which were sampled around power plants were analysed. With cooperation of Satellite Technology Research Center of KAIST, use of civilian satellite imagery was surveyed. To train facility operators for safeguards, various technology on non-destructive assay was lectured to personnel of Korea Electric Power Corporation. And to enhance out capabilities, non-destructive assay training was done at Los Alamos National Lab. of U.S. through the agreement of MOST and DOE agreement, and information on DA technology was exchanged at Nuclear Material Control Center of Japan. (author). 22 tabs., 52 figs., 53 refs

  15. The MAGLEV bogie system and its development

    Seino, Hiroshi [Railway Technical Research Inst., Maglev Systems Development Dept., Vehicle Engineering Div., Tokyo (Japan); Kato, Ken-ichi [Railway Technical Research Inst., Maglev Systems Development Dept., Vehicle Engineering Div., Tokyo (Japan); Oshima, Hiroshi [Central Japan Railway Co., Tokyo (Japan). Linear Express Development Div.; Azakami, Masayoshi [Railway Technical Research Inst., Maglev Systems Development Dept., Vehicle Engineering Div., Tokyo (Japan); Yoshioka, Hiroshi [Maglev Systems Technology Lab., Tokyo (Japan)

    1995-12-31

    A new Japan Railways (JR) MAGLEV vehicle was completed in the spring of this year, and the MAGLEV system is now being assembled and prepared on the Yamanashi test line. The completed vehicle consists of the `conventional MAGLEV bogie system`, with rigidly fitted on-board superconducting magnets (SCM). Meanwhile, the new concept of the `SCM resiliently-mounting method` and its controlling system have been continued to be studied and developed for the `new MAGLEV bogie system` on the Miyazaki test track since 1989. The `resiliently mounted SCM bogie system` is being developed and studied for the purpose of riding comfort in the sidewall levitation MAGLEV system, and valuable data were obtained from running tests on the Miyazaki test track. The bogie system for the second train set on the Yamanashi test line will adopt the `SCM resiliently-mounting method`. In this paper, the development of the JR MAGLEV bogie system and its properties are reported. (orig.)

  16. Highly reusability surface loaded metal particles magnetic catalyst microspheres (MCM-MPs) for treatment of dye-contaminated water

    Liu, Ying; Zhang, Kun; Yin, Xiaoshuang; Yang, Wenzhong; Zhu, Hongjun

    2016-04-01

    The metal-deposited magnetic catalyst microspheres (MCM-MPs) were successfully synthesized by one facile, high yield and controllable approach. Here, the bare magnetic microspheres were firstly synthesized according to the solvothermal method. Then silica shell were coated on the surface of the magnetic microspheres via sol-gel method, and subsequently with surface modifying with amino in the purpose to form SiO2-NH2 shell. Thus, metal particles were easily adsorbed into the SiO2-NH2 shell and in-situ reduced by NaBH4 solution. All the obtained products (MCM-Cu, MCM-Ag, MCM-Pd) which were monodisperse and constitutionally stable were exhibited high magnetization and excellent catalytic activity towards dyes solution reduction. The catalytic rate ratio of MCM-Pd: MCM-Cu: MCM-Ag could be 10:3:1. Besides, some special coordination compound Cu2(OH)3Br had been generated in the in-situ reduced process of MCM-Cu, which produced superior cyclical stability (>20 times) than that of MCM-Ag and MCM-Pd. In all, those highly reusability and great catalytic efficiency of MCM-MPs show promising and great potential for treatment of dye-contaminated water.

  17. Investigation of current transport parameters of Ti/4H-SiC MPS diode with inhomogeneous barrier

    Song Qing-Wen; Zhang Yu-Ming; Zhang Yi-Men; Chen Feng-Ping; Tang xiao-Yan

    2011-01-01

    The current transport parameters of 4H-SiC merged PiN Schottky (MPS) diode are investigated in a temperature range of 300-520 K. Evaluation of the experimental current-voltage (Ⅰ-Ⅴ) data reveals the decrease in Schottky barrier height φb but an increase in ideality factor n, with temperature decreasing, which suggests the presence of an inhomogeneous Schottky barrier. The current transport behaviours are analysed in detail using the Tung's model and the effective area of the low barrier patches is extracted. It is found that small low barrier patches, making only 4.3% of the total contact, may significantly influence the device electrical characteristics due to the fact that a barrier height of 0.968 eV is much lower than the average barrier height 1.39 eV. This shows that ion implantation in the Schottky contact region of MPS structure may result in a poor Ti/4H-SiC interface quality. In addition, the temperature dependence of the specific on-resistance (Ron-sp), T2.14, is determined between 300 K and 520 K, which is similar to that predicted by a reduction in electron mobility.

  18. The development of accelerator mass spectroscopy system

    Mitarai, Shiro; Machida, Atsushi; Iwata, Yasunao; Tsubusaki, Yoshihiro; Tanaka, Katsuhiko; Maeda, Toyokazu; Nakajima, Takao [Kyushu Univ., Fukuoka (Japan)

    2001-02-01

    Inverse PIXE method was applied to the differentiation of Chlorine 36 and Sulfur 36. The contaminated soil from the USSR nuclear test site was measured. Terminal potential of the tandem accelerator was controlled by GVM. A new AMS system, using time-of flight method is under development. The development of beam buncher and beam chopper for the system is briefly described. (A. Yamamoto)

  19. Notes on innovation systems and economic development

    Lundvall, Bengt-Åke

    2011-01-01

    This paper gives a brief history and background for the concept 'national innovation system' and discusses its usefulness for understanding and managing economic development.......This paper gives a brief history and background for the concept 'national innovation system' and discusses its usefulness for understanding and managing economic development....

  20. Factors Affecting the Adoption of Mobile Payment Systems: An Empirical Analysis

    İkram Daştan

    2016-02-01

    Full Text Available The world witnessed a rapid growth in the e-commerce in the recent years. Widespread use of mobile devices in the e-commerce has a role in this augmentation. Associated with growth of trading volume and the introduction of new devices, new products and solutions emerge and they diversify concerning online payments. Consumer attitudes and behaviors may change according to these developments. The purpose of this study is to investigate the factors effecting adoption of mobile payment systems by the consumer. 225 individuals were surveyed online through convenience sampling method. A research model was developed and proposed relationships were tested using structural equation modeling. The empirical findings point out that perceived trust, perceived mobility and attitudes positively affect the adoption of MPS; perceived usefulness and perceived ease of use have no effect on adoption of MPS. Furthermore perceived reputation positively related to perceived trust and finally environmental risk negatively related to perceived trust.

  1. Testing Infrastructure for Operating System Kernel Development

    Walter, Maxwell; Karlsson, Sven

    2014-01-01

    Testing is an important part of system development, and to test effectively we require knowledge of the internal state of the system under test. Testing an operating system kernel is a challenge as it is the operating system that typically provides access to this internal state information. Multi......-core kernels pose an even greater challenge due to concurrency and their shared kernel state. In this paper, we present a testing framework that addresses these challenges by running the operating system in a virtual machine, and using virtual machine introspection to both communicate with the kernel...... and obtain information about the system. We have also developed an in-kernel testing API that we can use to develop a suite of unit tests in the kernel. We are using our framework for for the development of our own multi-core research kernel....

  2. Solar heating and cooling systems design and development. [prototype development

    1977-01-01

    The development of twelve prototype solar heating/cooling systems, six heating and six heating and cooling systems, two each for single family, multi-family, and commercial applications, is reported. Schedules and technical discussions, along with illustrations on the progress made from April 1, 1977 through June 30, 1977 are detailed.

  3. Enterprise ontology based development of information systems

    Albani, Antonia; Dietz, Jan L.G.

    2011-01-01

    For the development of enterprise information systems, the utilisation of a suitable methodology is essential, providing necessary methods and techniques for modelling the business domain and for designing the supporting information systems. Several methodologies exist and are widely applied in practice nowadays, but most of them lack a theoretical foundation. In this paper, we demonstrate an information system development methodology based on the notions of enterprise ontology and business c...

  4. Pension Systems Development Problems in Latvia

    Voļskis, Edgars

    2008-01-01

    Edgars Volskis promotion paper „Pension System’s Development Problems in Latvia” analyses the theoretical aspects of establishment of pension systems, observes mechanisms of financing of pension budget and its sources, aspects of establishment and execution of the pension budget. There are also analysed main milestones of development of Latvian pension system from date of regaining of the independence until the completion moment of the latest reform of pension system. Second chapter of the wo...

  5. A Software Development Platform for Mechatronic Systems

    Guan, Wei

    Software has become increasingly determinative for development of mechatronic systems, which underscores the importance of demands for shortened time-to-market, increased productivity, higher quality, and improved dependability. As the complexity of systems is dramatically increasing, these demands...... present a challenge to the practitioners who adopt conventional software development approach. An effective approach towards industrial production of software for mechatronic systems is needed. This approach requires a disciplined engineering process that encompasses model-driven engineering and component...

  6. Recent development of cellular manufacturing systems

    P K Arora; A Haleem; M K Singh

    2013-06-01

    Cellular manufacturing system has been proved a vital approach for batch and job shop production systems. Group technology has been an essential tool for developing a cellular manufacturing system. The paper aims to discuss various cell formation techniques and highlights the significant research work done in past over the years and attempts to points out the gap in research.

  7. Development of steering system in network environment

    We have been developing the steering system, which can successively observe the-data obtained during the numerical computation and change the parameters in the analysis. Moreover, this system is also extended to link the network. By using this system, a user can easily detect errors immediately and achieve the rapid and accurate analysis with lower computation cost. (Author)

  8. Toward the Development of Expert Assessment Systems.

    Hasselbring, Ted S.

    1986-01-01

    The potential application of "expert systems" to the diagnosis and assessment of special-needs children is examined and existing prototype systems are reviewed. The future of this artificial intelligence technology is discussed in relation to emerging development tools designed for the creation of expert systems by the lay public. (Author)

  9. Developing Sustainable Life Support System Concepts

    Thomas, Evan A.

    2010-01-01

    Sustainable spacecraft life support concepts may allow the development of more reliable technologies for long duration space missions. Currently, life support technologies at different levels of development are not well evaluated against each other, and evaluation methods do not account for long term reliability and sustainability of the hardware. This paper presents point-of-departure sustainability evaluation criteria for life support systems, that may allow more robust technology development, testing and comparison. An example sustainable water recovery system concept is presented.

  10. Sonic hedgehog signaling during nervous system development

    Qin Yang; Peng Xie

    2008-01-01

    The Hedgehog signaling pathway plays a key role in embryonic development and organ formation.Sonic hedgehog signaling participates in nervous system development,regulates proliferation and differentiation of neural stem cells,controls growth and targeting of axons,and contributes to specialization of oligodendrocytes.For further studies of the Sonic hedgehog signaling pathway and for the development of new drugs in the treatment of nervous system diseases,it is beneficial to understand these mechanisms.

  11. Tribes of Users and System Developers

    Sharon Dingley

    2000-05-01

    Full Text Available Effective communication is essential for information systems development crossing functional, organisational and national boundaries. As organisations attempt to overcome cultural barriers to communication across the world, communication with colleagues across the corridor remains problematic; cultural barriers between departments remain unchallenged. This paper introduces the concepts of 'culture' and 'tribe' into the discussion of the relationship between business users and information systems developers. Previous research has focused on identifying specific barriers to user-systems developer communication and on ways of eliminating these barriers. In contrast, this paper suggests that much can be learnt through the recognition of cultural differences inherent to the differing roles of user and systems developer. Maintenance of cultural identity is essential to the individual if he/she is to function effectively as a member of his/her tribe, whether it is the 'tribe' of developers or the 'tribe' of users. Communication problems within the systems development process may be addressed by a mutual understanding of cultural differences between the 'tribes' of users and systems developers. This degree of understanding cannot be achieved by attempting to change, persuade or convert the other tribe. The problems of user-systems developer communication need to be addressed through effective communication which acknowledges the differing cultures.

  12. Development of the Hypothalamic Melanocortin System

    SebastienGBouret

    2013-01-01

    The melanocortin system is a critical component of the forebrain and hindbrain regulatory systems involved in energy balance. This system is composed of pro-opiomelanocortin (POMC) neurons that act, in part, through the melanocortin-4 receptor (MC4R). Although the importance of the melanocortin system in controlling feeding has been established for two decades, the understanding of the developmental substrates underlying POMC and MC4R neuron development and function has just begun to emerge. ...

  13. Psychology of developing and designing expert systems

    Tonn, B.; MacGregor, D.

    1986-01-01

    This paper discusses psychological problems relevant to developing and designing expert systems. With respect to the former, the psychological literature suggests that several cognitive biases may affect the elicitation of a valid knowledge base from the expert. The literature also suggests that common expert system inference engines may be quite inconsistent with reasoning heuristics employed by experts. With respect to expert system user interfaces, care should be taken when eliciting uncertainty estimates from users, presenting system conclusions, and ordering questions.

  14. Recent Developments on Chaos in Mechanical Systems

    Mohammad Sajid

    2013-01-01

    Recent advancements in complexity of mechanical systems have led to the application of chaos theory. In this paper, some recent developments on chaos in mechanical systems are explored. The aim is to bring together researchers from various interests of mechanical systems, exposing them to chaos theory. This exposure gives researchers from the discipline of mechanical systems to find opportunity of cross disciplinary research, which may ultimately lead to novel solutions and understanding of m...

  15. Systems Engineering Leadership Development: Advancing Systems Engineering Excellence

    Hall, Phil; Whitfield, Susan

    2011-01-01

    This slide presentation reviews the Systems Engineering Leadership Development Program, with particular emphasis on the work being done in the development of systems engineers at Marshall Space Flight Center. There exists a lack of individuals with systems engineering expertise, in particular those with strong leadership capabilities, to meet the needs of the Agency's exploration agenda. Therefore there is a emphasis on developing these programs to identify and train systems engineers. The presentation reviews the proposed MSFC program that includes course work, and developmental assignments. The formal developmental programs at the other centers are briefly reviewed, including the Point of Contact (POC)

  16. System model development for nuclear thermal propulsion

    A critical enabling technology in the evolutionary development of nuclear thermal propulsion (NTP) is the ability to predict the system performance under a variety of operating conditions. Since October 1991, US (DOE), (DOD) and NASA have initiated critical technology development efforts for NTP systems to be used on Space Exploration Initiative (SEI) missions to the Moon and Mars. This paper presents the strategy and progress of an interagency NASA/DOE/DOD team for NTP system modeling. It is the intent of the interagency team to develop several levels of computer programs to simulate various NTP systems. An interagency team was formed for this task to use the best capabilities available and to assure appropriate peer review. The vision and strategy of the interagency team for developing NTP system models will be discussed in this paper. A review of the progress on the Level 1 interagency model is also presented

  17. SP-100 power system development status

    The SP-100 ground engineering system development project objectives, approach and status are described. The SP-100 GES development project is phase II of a three-phase program funded and directed by three United States Federal Agencies (NASA, DOD and DOE) to develop space reactor power systems for space applications in the 10 to 1000 KWe power range. The first phase of the program lasted three years, and this was completed at the end of FY 1985. SP-100 Phase I analytically and experimentally reviewed all near-term space reactor power system candidates and selected one system that best met the project mission requirements for future civilian and military space applications. The SP-100 Phase II started in fiscal year 1986 to develop the Phase I selected space reactor power system to be technically ready for space applications in the mid-to late 1990s. (author)

  18. Identification, expression, and biochemical characterization of N-acetylgalactosamine-4-sulfatase mutations and relationship with clinical phenotype in MPS-VI patients

    Litjens, T.; Brooks, D.A.; Hopwood, J.J. [Women`s and Children`s Hospital, North Adelaide (Australia)] [and others

    1996-06-01

    Maroteaux-Lamy syndrome, or mucopolysaccharidosis type VI (MPS-VI), is a lysosomal storage disorder characterized by the defective degradation of dermatan sulfate due to the deficiency of N-acetylgalactosamine-4-sulfatase (4S). The clinical severity of MPS-VI ranges in a continuum from mildly affected to severely affected patients. Mutations in MPS-VI patient samples were identified by chemical cleavage and direct DNA sequencing of PCR products derived from patient cDNA. Five amino acid substitutions were identified (T92M, R95Q, Y210C, H393P, and L498P), individually introduced into the wild-type 4S cDNA by site-directed in vitro mutagenesis, and transfected into Chinese hamster ovary cells. Three of the five mutations (R95Q, Y210C, and H393P) were observed in > 1 of 25 unrelated MPS-VI patients; however, the mutations were not found in 20 control individuals. The residual 4S activity and protein (biochemical phenotype) were determined for each mutant in order to confirm their identity as mutations and to dissect the contribution of each mutant allele to the overall clinical phenotype of the patient. For each patient, the combined biochemical phenotypes of the two 4S mutant alleles demonstrated a good correspondence with the observed clinical phenotype (with the possible exception of a patient who was a compound heterozygote for T92M and L498P). This preliminary correspondence between genotype and the phenotype in MPS-VI may, with further refinement, contribute to the assessment of therapeutic approaches for MPS-VI patients. 30 refs., 4 tabs.

  19. Software systems development in petroleum engineering

    Browning, D. J.; Cain, G. M.; Carmichael, N. P.; Gouldstone, F. G.; Wadsley, A. W.; Webb, S. J.; Winder, P.

    1985-10-01

    Many approaches to designing software systems have been developed for use in commercial or business environments. These development methods and procedures have improved dramatically over the last ten years although it is only recently that these have been employed in scientific and technological applications. Many of these implementations have been unsuccessful because the design methodology has been divorced from the practical requirements of the industry in which the software system is to operate. This paper discusses a modern approach to software development which directly relates to an engineering environment and which is designed to satisfy practical criteria of acceptability of the software when delivered to the petroleum engineer. Since all field developments nowadays rely heavily on associated software systems, the approach presented here can lead to improved mechanical systems reliability and shorter development/design cycles.

  20. Gas tagging system development in Japan

    The Gas tagging method has been considered to be most desirable for a failed fuel location system for the fast breeder reactor, regarding the component reduction in the reactor vessel and rapid location during reactor operation. The gas tagging system has been designed by referring to R and D results obtained in Japan and other countries. The designed system is comprised of tag gas filling pins, cover gas sampling system, tag gas recovery and enrichment system, tag gas analyzer and system control and data handling computers. The main specifications for this system have been decided as follows; 1) Main function is location of failed fuels in core and a part of blanket region, 2) Identification capability is each subassembly, 3) Time for identification is within a few days, 4) Continuous operation with automatic start at fuel failure, 5) Detection sensitivity must cover both gas leak and pin burst. In designing the gas tagging system, the following R and D items were selected; 1) System design study, 2) Tag gas capsule development, 3) Modeling the tag gas behavior in reactor primary cooling system, 4) Tag gas recovery and enrichment system, 5) Computer code development for tag gas isotope ratio change estimation. Details of the Japanese gas tagging system development appear in this paper. (author)

  1. Development of a Sound Quality Evaluation System

    Kvist, Preben; Thomsen, Carsten; Lee, Sanjil; Park, Joonhyun; Agerkvist, Finn T.

    2004-01-01

    This paper describes the development of the first version of the Sound Quality Evaluation System. The purpose of the system is to predict the subjective sound quality of home theater systems from objective measurements. 16 home theater systems were measured in an anechoic room. Several metrics...... expected to correlate w ith the subjective quality were proposed and tested. A model for the sound quality was created by mapping the subjective evaluations of the Home Theater System s with the metrics calculated for each system. Correlation between subjective listening test and the prediction is presente...

  2. Space Shuttle Main Propulsion System Anomaly Detection: A Case Study

    National Aeronautics and Space Administration — The space shuttle main engine (SSME) is part of the Main Propnlsion System (MPS) which is an extremely complex system containing several sub-systems and components,...

  3. Development of the Digital Reactor Safety System

    Objectives of Project - Development of Digital Safety Grade PLC and Licensing - Development of Safety System(RPS) and Licensing - Development of Safety System(ESF-CCS) and Licensing Content and Result of Project - POSAFE-Q PLC : Development of PLC platform for Shin-UCN unit 1 and 2 ·Development Scope : Processor module, Power module, 3 kinds of Communication module, Bus extension module(Master and Slave), 16 kinds of Input and Output module ·PLC application software development tool(pSET) - IDiPS RPS and IDiPS ESF-CCS : Development of PPS for Sin-UCN 1 and 2 ·Development Scope - 4-channels RPS with the KNICS inherent architecture - A part of 1-channels ESF-CCS with the KNICS inherent architecture - Licensing ·optical Report Submitted and Expected to finish the licensing process until Aug. 2008

  4. Development of environment radiation database management system

    Kang, Jong Gyu; Chung, Chang Hwa; Ryu, Chan Ho; Lee, Jin Yeong; Kim, Dong Hui; Lee, Hun Sun [Daeduk College, Taejon (Korea, Republic of)

    1999-03-15

    In this development, we constructed a database for efficient data processing and operating of radiation-environment related data. Se developed the source documents retrieval system and the current status printing system that supports a radiation environment dta collection, pre-processing and analysis. And, we designed and implemented the user interfaces and DB access routines based on WWW service policies on KINS Intranet. It is expected that the developed system, which organizes the information related to environmental radiation data systematically can be utilize for the accurate interpretation, analysis and evaluation.

  5. Development of environment radiation database management system

    In this development, we constructed a database for efficient data processing and operating of radiation-environment related data. Se developed the source documents retrieval system and the current status printing system that supports a radiation environment dta collection, pre-processing and analysis. And, we designed and implemented the user interfaces and DB access routines based on WWW service policies on KINS Intranet. It is expected that the developed system, which organizes the information related to environmental radiation data systematically can be utilize for the accurate interpretation, analysis and evaluation

  6. Prognostication of regional energy system development

    Grigoriy Borisovich Korovin

    2011-06-01

    Full Text Available This paper analyzes practice and development of new methodological approaches to forecasting the development of regional energy systems. It is shown that the energy complex is involved in a variety of forward and backward linkages as an element of socio-economic systems, and the quality and availability of energy resources largely determines the structure and pace of economic, social and environmental development of the region. Analysis of existing current practice of territorial and sectoral forecasting implemented in Russia and abroad, suggests that such practice is inadequate in its theoretical and methodological elaboration. This is confirmed by the frequent discrepancy between actual results and plans, as well as their regular revision. The methods are mostly based on extrapolation of existing tendencies and not taking into account many factors and emerging trends related to the complexity and openness of the social and economic systems. Post-industrial level of civilization is characterized by fast development of technology; knowledge, information, technological and institutional innovation become the main resources. The greatest importance is attached to such development properties as instability, various orderliness, nonlinearity, interactions etc. Current approaches to forecasting the future are described by a number of theories that are generally called self-organization theory, taking into account these singularities. These concepts should be included in the theoretical basis for the development and implementation of regional development forecasts. Using the synergetic approach assumes that, along with organizational processes, processes of self-organization and self-development are very important in the system, they are characterized by spontaneous, unexpected formations and emerging structures. The development of such systems can generate stable and efficient new structure. The presence of crisis is an integral feature of complex

  7. System theoretic approach to sustainable development problems

    Batanović Vladan

    2011-01-01

    Full Text Available This paper shows that the concepts and methodology contained in the system theory and operations research are suitable for application in the planning and control of the sustainable development. The sustainable development problems can be represented using the state space concepts, such as the transition of system, from the given initial state to the final state. It is shown that sustainable development represents a specific control problem. The peculiarity of the sustainable development is that the target is to keep the system in the prescribed feasible region of the state space. The analysis of planning and control problems of sustainable development has also shown that methods developed in the operations research area, such as multicriteria optimization, dynamic processes simulation, non-conventional treatment of uncertainty etc. are adequate, exact base, suitable for resolution of these problems.

  8. The Development of Oromo Writing System

    Degeneh Bijiga, Teferi

    2015-01-01

    The development and use of languages for official, education, religion, etc. purposes have been a major political issue in many developing multilingual countries. A number of these countries, including China and India, have recognised the issues and developed language policies that have provided some ethnic groups with the right to develop their languages and cultures by using writing systems based on scripts suitable for these purposes. On the other hand, other countries, such as Ethiopia (a...

  9. Horse-like walking, trotting, and galloping derived from kinematic Motion Primitives (kMPs) and their application to walk/trot transitions in a compliant quadruped robot

    Moro, Federico L.; Sprowitz, Alexander; Tuleu, Alexandre; Vespignani, Massimo; Tsagarakis, Nikos G.; Ijspeert, Auke J.; Caldwell, Darwin G.

    2013-01-01

    This manuscript proposes a method to directly transfer the features of horse walking, trotting, and galloping to a quadruped robot, with the aim of creating a much more natural (horse-like) locomotion profile. A principal component analysis on horse joint trajectories shows that walk, trot, and gallop can be described by a set of four kinematic Motion Primitives (kMPs). These kMPs are used to generate valid, stable gaits that are tested on a compliant quadruped robot. Tests on the effects of ...

  10. Development of Bio-GAS systems

    Takayanagi, M.; Kitamura, S.; Nemoto, H.; Kimura, T.; Zaiki, Y.; Kitakohji, T.; Fujita, S.; Kameda, M.; Noda, M.; Kawasaki, Y.

    1988-01-01

    Four experiment systems which have fundamental significance in the field of biotechnology are developed for the Get Away Special (GAS). Unique considerations were necessary to develop the systems which carry out biotechnological experiments under GAS's restricted conditions: delicate thermal control, fluid handling and protection from contamination. All experimental processes are controlled by internal sequencers and results of the experiments are recorded as images and numerical data within the systems. The systems are standardized in order to enable repeated use with a variety of experiments by replacement of the experiment modules and modification of experiment sequencing programs.

  11. Natural History and Galsulfase Treatment in Mucopolysaccharidosis VI (MPS VI, Maroteaux-Lamy Syndrome) — 10 Year Follow-up of Patients Who Previously Participated in an MPS VI Survey Study

    Giugliani, Roberto; Lampe, Christina; Guffon, Nathalie; Ketteridge, David; Teles, Elisa Leão; Wraith, James E.; Jones, Simon A; Piscia-Nichols, Cheri; Lin, Ping; Quartel, Adrian; Harmatz, Paul

    2014-01-01

    Mucopolysaccharidosis VI (MPS VI) is a clinically heterogeneous and progressive disorder with multiorgan manifestations caused by deficient N-acetlylgalactosamine-4-sulfatase activity. A cross-sectional Survey Study in individuals (n=121) affected with MPS VI was conducted between 2001–2002 to establish demographics, urinary glycosaminoglycan (GAG) levels, and clinical progression of disease. We conducted a Resurvey Study (ClinicalTrials.gov: NCT01387854) to obtain 10-year follow-up data, including medical histories and clinical assessments (n=59), and survival status over 12-years (n=117). Patients received a mean (SD) of 6.8 (2.2) years of galsulfase ERT between baseline (Survey Study) and follow-up. ERT patients increased in height by 20.4 cm in the 4–7 year-old baseline age group and by 16.8 cm in the 8–12 year-old baseline age group. ERT patients 200 µg/mg baseline uGAG levels increased FVC by 48% in the <13 year-old and by 15% in the ≥13 year-old baseline age group. ERT patients who completed the 6-minute walk test demonstrated a mean (SD) increase of 65.7 (100.6) m. Cardiac outcomes did not significantly improve or worsen. Observed mortality rate among naïve patients was 50% (7/14) and 16.5% (17/103) in the ERT group (unadjusted hazard ratio, 0.24; 95% CI, 0.10 to 0.59). Long-term galsulfase ERT was associated with improvements in pulmonary functions and endurance, stabilized cardiac function and increased survival. PMID:24764221

  12. Development of the stock exchange information system

    Miladinović Radojko

    2006-01-01

    Full Text Available The stock exchange represents the key institution for the development of capital market of any country. Thus the information system of every stock exchange must satisfy very strict international standards. The development of these systems is particularly difficult in countries in transition, due to intense economic and legal changes, lack of technical and financial resources, lack of experience and knowledge in the area of the capital market business, etc. Therefore the special software project management methodology for their realization must be clearly defined. In the development process of the Belgrade Stock Exchange (BSE information system a new software project management methodology for its realization has been defined, the application of which is illustrated through a series of different development stages of the Belgrade Stock Exchange information system. In order to make all the problems more comprehensive, only the continuous trading method is described, being the most frequently used trading method in the world.

  13. Research and Development Information System (RDIS)

    Department of Veterans Affairs — The Research and Development Information System (RDIS) is the Veterans Affairs Central Office budgetary and project data repository for managing the VA Research and...

  14. Progress in the Development of Nanotheranostic Systems

    Cui, Honggang; Wang, Jun

    2016-01-01

    This thematic issue includes both review and research articles and is intended to provide an overview on the recent progress in the development of nanostructure-based therapeutic, diagnostic, and theranostic systems. PMID:27217827

  15. Usability Factors in Information Systems Development

    K. Chandra Sekharaiah

    2014-07-01

    Full Text Available Computers have become a commonplace technology for today’s man. Computer users demand more reliable and durable interfaces from information processing applications developers. Information systems (ISs research and development, over the years, has been steady so well that the arena has now grown into various subfields such as Cognitive Information Systems (CISs, Web Information Systems(WISs, Geographical Information Systems(GISs, Enterprise Information Systems (EISs, and so forth. Of late, ergonomics specialization too has begun to percolate into the field making it more cross-fertilizing with concerns for successful deployment, a win-win model of development and look-and-feel factor in terms of durable usage and usability. The paper presents a novel taxonomy of computer ergonomics.

  16. On Using Materiality in Information Systems Development

    Carugati, Andrea

    This research brief presents a discussion on the use of the concept of materiality and material knowing in information systems development (ISD). The discussion addresses some of the practical problems still plaguing ISD, augmenting existing ISD methodologies with contributions from systems theory...... and in particular the idea of inquiring systems. The discussion builds on different contemporary concepts that are rooted in the inquiring systems idea: the notion of stakeholders (designer, client, user and their interchanging roles), the notion boundary object and boundary spanners, and the notion...... of materiality as scaffold of knowledge. Through the example taken from a case study of a complex and innovative systems development we outline two design principles to be embedded in modular fashion in ISD processes: (1) whenever possible start ISD efforts by developing a graphical simulator of the...

  17. System Administrator for LCS Development Sets

    Garcia, Aaron

    2013-01-01

    The Spaceport Command and Control System Project is creating a Checkout and Control System that will eventually launch the next generation of vehicles from Kennedy Space Center. KSC has a large set of Development and Operational equipment already deployed in several facilities, including the Launch Control Center, which requires support. The position of System Administrator will complete tasks across multiple platforms (Linux/Windows), many of them virtual. The Hardware Branch of the Control and Data Systems Division at the Kennedy Space Center uses system administrators for a variety of tasks. The position of system administrator comes with many responsibilities which include maintaining computer systems, repair or set up hardware, install software, create backups and recover drive images are a sample of jobs which one must complete. Other duties may include working with clients in person or over the phone and resolving their computer system needs. Training is a major part of learning how an organization functions and operates. Taking that into consideration, NASA is no exception. Training on how to better protect the NASA computer infrastructure will be a topic to learn, followed by NASA work polices. Attending meetings and discussing progress will be expected. A system administrator will have an account with root access. Root access gives a user full access to a computer system and or network. System admins can remove critical system files and recover files using a tape backup. Problem solving will be an important skill to develop in order to complete the many tasks.

  18. The issue of contract system development

    Obalyaeva Julia, I.; Cherniy Andrew, S.

    2015-01-01

    The role of contract system and its institutions in the national economy, the development of public procurement, the rational use of budgetary funds is explored in the paper. Dynamics of purchases in electronic trading for 2011-2014 is given. Author's vision on the problems in the formation and development institutions such as tendering and organization of interaction of participants of procurement on an electronic platform is submitted. Among the institutions of the contract system stand out...

  19. Development of collaborative green lean production systems

    Kurdve, Martin

    2014-01-01

    This thesis deals with development of lean and green production systems from an action research point of view. The studies focus on Swedish-based automotive and vehicle industries and their aims to integrate sustainable thinking and environmental care into their operations management. Starting from operations management in manufacturing and corporate sustainable development, the research is built on how to integrate these two views into one production system. The systematic structure of a mul...

  20. Development of the stock exchange information system

    Miladinović Radojko

    2006-01-01

    The stock exchange represents the key institution for the development of capital market of any country. Thus the information system of every stock exchange must satisfy very strict international standards. The development of these systems is particularly difficult in countries in transition, due to intense economic and legal changes, lack of technical and financial resources, lack of experience and knowledge in the area of the capital market business, etc. Therefore the special software proje...

  1. Development of a simplified piping support system

    This paper presents the results of experimental and analytical studies for developing a simplified piping support system (SPSS) for nuclear power piping in place of snubbers. The basic concept of the SPSS is a passive seismic support system consisting of limit stops. Large gaps are provided to allow for free thermal expansion during normal plant operation while preventing excessive displacement during a seismic event. The results are part of a research and development program sponsored by EPRI. (orig./HP)

  2. Development of portable driving simulator system

    Itoh, Y; Nemoto, T.; Matsuura, H.; M. Kihira; S. Yanai

    2008-01-01

    Purpose: In accordance with aging of populations in many developed countries, number of drivers who suffer from mild cognitive impairment (MCI drivers) is increasing. Since it has been reported that driving skill of the MCI drivers are deteriorated, it is important to train themselves in driving situation to preserve their driving skills. The present study was conducted to develop the simple driving simulator system, and to examine the effect of training in this system.Design/methodology/appr...

  3. Hydrogen storage and delivery system development: Fabrication

    Handrock, J.L.; Malinowski, M.E.; Wally, K. [Sandia National Lab., Livermore, CA (United States)

    1996-10-01

    Hydrogen storage and delivery is an important element in effective hydrogen utilization for energy applications and is an important part of the FY1994-1998 Hydrogen Program Implementation Plan. This project is part of the Field Work Proposal entitled Hydrogen Utilization in Internal Combustion Engines (ICE). The goal of the Hydrogen Storage and Delivery System Development Project is to expand the state-of-the-art of hydrogen storage and delivery system design and development. At the foundation of this activity is the development of both analytical and experimental evaluation platforms. These tools provide the basis for an integrated approach for coupling hydrogen storage and delivery technology to the operating characteristics of potential hydrogen energy use applications. Analytical models have been developed for internal combustion engine (ICE) hybrid and fuel cell driven vehicles. The dependence of hydride storage system weight and energy use efficiency on engine brake efficiency and exhaust temperature for ICE hybrid vehicle applications is examined. Results show that while storage system weight decreases with increasing engine brake efficiency energy use efficiency remains relatively unchanged. The development, capability, and use of a newly developed fuel cell vehicle hydride storage system model will also be discussed. As an example of model use power distribution and control for a simulated driving cycle is presented. An experimental test facility, the Hydride Bed Testing Laboratory (HBTL) has been designed and fabricated. The development of this facility and its use in storage system development will be reviewed. These two capabilities (analytical and experimental) form the basis of an integrated approach to storage system design and development. The initial focus of these activities has been on hydride utilization for vehicular applications.

  4. The engineering of microprocessor systems guidelines on system development

    1979-01-01

    The Engineering of Microprocessor Systems: Guidelines on System Development provides economical and technical guidance for use when incorporating microprocessors in products or production processes and assesses the alternatives that are available. This volume is part of Project 0251 undertaken by The Electrical Research Association, which aims to give managers and development engineers advice and comment on the development process and the hardware and software needed to support the engineering of microprocessor systems. The results of Phase 1 of the five-phase project are contained in this fir

  5. Epigenetic Systems View of Human Development.

    Gottlieb, Gilbert

    1991-01-01

    Discusses the history of the hierarchical epigenetic systems view as applied to human development and offers examples of its implementation. Notes the agreement by many authors that the multilevel systems view is the right model for developmental psychology in both human and animal studies. (BC)

  6. Financial system development in transition economies

    Hermes, C.L.M.; Lensink, B.W.

    2000-01-01

    This paper provides an overview of the major issues with respect to financial system development in transition economies, which were discussed at a conference in Groningen, the Netherlands, December 1997. After a brief remark on the role of financial system design during economic transition, the pap

  7. Development of the Choctaw Health Delivery System.

    Nguyen, Binh N.

    The Choctaw Tribe is the first and only tribe to develop a health delivery system to take over an existing Indian Health Service inpatient facility. The takeover was accomplished in January 1984 under the Indian Self-Determination Act through a contract with the Indian Health Service. The Choctaw Health Delivery System includes a 35-bed general…

  8. Development of Smart Underfrequency Load Shedding System

    Čuvičins, V; Petričenko, R

    2012-01-01

    Paper describes possibility to apply innovation technology of Smart Grid for power system emergency automation. Operational characteristics of existing emergency automation and new suggested one are compared in the paper. The method for liquidation of drawback of existing automation is suggested. Paper describes developed mathematical model of intellectual underfrequency load shedding system and its operational algorithms.

  9. Developing a Mobile Distance Learning System

    Rogov, Petr; Borisov, Nikolay

    2007-01-01

    This article considers the basic problems of client-server electronic learning systems based on mobile platforms. Such questions as relational learning course model and student’s transitions prediction through the learning course items are considered. Besides, technical questions of electronic learning system “E-Learning Suite” realization and questions of developing portable applications using .NET Framework are discussed.

  10. The Development of Computer Music Programming Systems

    Lazzarini, Victor

    2013-01-01

    This article traces the history and evolution of Music Programming, from the early off-line synthesis programs of the MUSIC N family to modern realtime interactive systems. It explores the main design characteristics of these systems and their impact on Computer Music. In chronological fashion, the article will examine, with code examples, the development of the early systems into the most common modern languages currently in use. In particular, we will focus on Csound, highlighting its main ...

  11. The HS6000/20 development system

    In the actual control system of MEA, NIKHEF-K three color displays are in use for graphical representation of the accelerator status information. At the moment the quality of the color displays is bad. The HS6000 development system of the English company Syntel seems to offer a possible solution to replace these displays. In the development system software is developed which finally may run on a target module. The target module, consisting of a processor card with memory and RS232 port and a graphical card, takes care for the control of a color display. The institute has disposed of an experimental set up during two weeks in order to investigate the possibilities and limitations of the development system. The HS6000 development system runs under the OS-9 multi-user and multi-tasking operating system. The operating system takes care for a part of the necessary software to render a computer valuable. The OS-9 operating system disposes of about 60 utility commands. A feature of OS-9 is the application of modular software technique which are based upon memory modules. The interface between the user and the internal functions of the operating system is formed from the shell, the OS-9 command-interpreter code. The software, which has to run on the target module, is written with the help of the Mmacs screen editor, the draw program and the medit editor. The draw program and the medit editor form part of the EGOS ( Enhanced Graphical Output Software) packet. The EGOS packet is a multi-tasking graphical interface for the OS-9 operating system. (author). 1 fig

  12. Toward a Cooperative Experimental System Development Approach

    Grønbæk, Kaj; Kyng, Morten; Mogensen, Preben Holst

    1997-01-01

    This chapter represents a step towards the establishment of a new system development approach, called Cooperative Experimental System Development (CESD). CESD seeks to overcome a number of limitations in existing approaches: specification oriented methods usually assume that system design can be...... realisation from concrete activities and techniques. Thus we introduce a CESD model which provides a framework for handling this separation and at the same time makes it possible to identify and discuss the rich variety of relationships among concrete activities and the main concerns....

  13. Instructional systems development model for interactive videodisc

    Campbell, J. O.; Tuttle, D. M.; Gibbons, A. S.

    1983-12-01

    This is the third and final report on an Instructional Systems Development Model for Videodisc Training Delivery Systems with Interactive Capability. The report reviews the current state of the art, and describes two videodiscs made for the project, with lessons learned from them. Each block of the Interservice Procedures for Instructional Systems Development (IPISD) is described in terms of the new opportunities and requirements of interactive videodisc. A separate report, "Interactive Videodisc Design and Production Workshop Guide,' presents a step by step procedure for making interactive videodiscs.

  14. MODEL DRIVEN DEVELOPMENT OF ONLINE BANKING SYSTEMS

    Bresfelean Vasile Paul

    2011-07-01

    Full Text Available In case of online applications the cycle of software development varies from the routine. The online environment, the variety of users, the treatability of the mass of information created by them, the reusability and the accessibility from different devices are all factors of these systems complexity. The use of model drive approach brings several advantages that ease up the development process. Working prototypes that simplify client relationship and serve as the base of model tests can be easily made from models describing the system. These systems make possible for the banks clients to make their desired actions from anywhere. The user has the possibility of accessing information or making transactions.

  15. Development of the simulation monitoring system

    Kato, Katsumi [Research Organization for Information Science and Technology, Tokai, Ibaraki (Japan); Watanabe, Tadashi; Kume, Etsuo [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    2001-01-01

    Large-scale simulation technique is studied at the Center for Promotion of Computational Science and Engineering for the computational science research in nuclear fields. Visualization and animation processing techniques are developed for efficient understanding of simulation results. The development of the simulation monitoring system, which is used for real-time visualization of ongoing simulations or for successive visualization of calculated results, is described in this report. The standard visualization tool AVS5 or AVS/EXPRESS is used for the simulation monitoring system, and thus, this system can be utilized in various computer environments. (author)

  16. Development of the simulation monitoring system

    Large-scale simulation technique is studied at the Center for Promotion of Computational Science and Engineering for the computational science research in nuclear fields. Visualization and animation processing techniques are developed for efficient understanding of simulation results. The development of the simulation monitoring system, which is used for real-time visualization of ongoing simulations or for successive visualization of calculated results, is described in this report. The standard visualization tool AVS5 or AVS/EXPRESS is used for the simulation monitoring system, and thus, this system can be utilized in various computer environments. (author)

  17. Online Faculty Development and Assessment System (OFDAS)

    Luis M. Villar; Olga M. Alegre

    2006-01-01

    The rapid growth of online learning has led to the development of faculty inservice evaluation models focused on quality improvement of degree programs. Based on current 'best practices' of student online assessment, the Online Faculty Development and Assessment System (OFDAS), created at the Canary Islands, was designed to serve the dual purpose of faculty development and classroom learning environment assessment. Results, as illustrated in this paper, show that the OFDAS encouraged faculty ...

  18. The development of air cooled condensation systems

    EGI - Contracting/Engineering has had experience with the development of air cooled condensing systems since the 1950's. There are two accepted types of dry cooling systems,the direct and the indirect ones. Due to the fact that the indirect system has several advantages over the direct one, EGI's purpose was to develop an economic, reliable and efficient type of indirect cooling system, both for industrial and power station applications. Apart from system development, the main components of dry cooling plant have been developed as well. These are: the water-to-air heat exchangers; the direct contact (DC, or jet) condenser; the cooling water circulating pumps and recovery turbines; and the peak cooling/preheating units. As a result of this broad development work which was connected with intensive market activity, EGI has supplied about 50% of the dry cooling plants employed for large power stations all over the world. This means that today the cumulated capacity of power units using Heller type dry cooling systems supplied and contracted by EGI is over 6000 MW

  19. PLM system support for modular product development

    Bruun, Hans Peter Lomholt; Mortensen, Niels Henrik; Harlou, Ulf;

    2015-01-01

    (PDM) and product lifecycle management (PLM) systems offer support by automating and managing some of the operational complexity of modular design activities. PLM system tools are used for handling a variety of product definitions, to manage workflow of development activities, and to measure relational...... properties such as cost and performance. Companies often use a PLM tool for management of CAD files, documents, and drawings, but they do not take advantage of the full potential of the PLM system to support the development activities of modular product designs. The key result of this paper is the...... description of an empirical tested approach using a visual product architecture representation in combination with a PLM system to support the development of a product family of products. The results from the study encompass new PLM capabilities for handling multiple product structures, visualising multiple...

  20. Development of pellet injection systems for ITER

    Oak Ridge National Laboratory (ORNL) has been developing innovative pellet injection systems for plasma fueling experiments on magnetic fusion confinement devices for about 20 years. Recently, the ORNL development has focused on meeting the complex fueling needs of the International Thermonuclear Experimental Reactor (ITER). In this paper, we describe the ongoing research and development activities that will lead to a ITER prototype pellet injector test stand. The present effort addresses three main areas: (1) an improved pellet feed and delivery system for centrifuge injectors, (2) a long-pulse (up to steady-state) hydrogen extruder system, and (3) tritium extruder technology. The final prototype system must be fully tritium compatible and will be used to demonstrate the operating parameters and the reliability required for the ITER fueling application

  1. Development of minimally invasive surgery systems

    This review describes the minimally invasive surgery systems developed by the Hitachi group in cooperation with some Japanese universities. Those systems are ''intelliOpe'', a micromanipulator system and ''Naviot''. intelliOpe'', which was developed in cooperation with Tokyo Women's Medical University, is an operation room system with an open MRI equipment by which the image information is available during surgery. The system started from March 2000 and was adopted for 166 brain tumor patients until May 2003. The mean and whole extirpation rates were 91% and 39% respectively, while whole extirpation rate in Japan is 8%. The micromanipulator system for the brain surgery was developed in cooperation with Shinshu University. It consists of 3 micromanipulators and an endoscope, and has been found useful after the first clinical use in August 2002. ''Naviot'' is a laparoscopic manipulator system with a five-bar linkage mechanism recently developed in cooperation with Tokyo University and Kyushu University. ''Naviot'' made it possible for the surgeons to change endoscopic sites easily and safely. As a Hitachi product, ''Naviot'' has been practically used for 51 cases in 16 hospitals until June 2003. (N.I.)

  2. Proximity sensor system development. CRADA final report

    Lockheed Martin Energy Research Corporation (LMERC) and Merritt Systems, Inc. (MSI) entered into a Cooperative Research and Development Agreement (CRADA) for the development and demonstration of a compact, modular proximity sensing system suitable for application to a wide class of manipulator systems operated in support of environmental restoration and waste management activities. In teleoperated modes, proximity sensing provides the manipulator operator continuous information regarding the proximity of the manipulator to objects in the workspace. In teleoperated and robotic modes, proximity sensing provides added safety through the implementation of active whole arm collision avoidance capabilities. Oak Ridge National Laboratory (ORNL), managed by LMERC for the United States Department of Energy (DOE), has developed an application specific integrated circuit (ASIC) design for the electronics required to support a modular whole arm proximity sensing system based on the use of capacitive sensors developed at Sandia National Laboratories. The use of ASIC technology greatly reduces the size of the electronics required to support the selected sensor types allowing deployment of many small sensor nodes over a large area of the manipulator surface to provide maximum sensor coverage. The ASIC design also provides a communication interface to support sensor commands from and sensor data transmission to a distributed processing system which allows modular implementation and operation of the sensor system. MSI is a commercial small business specializing in proximity sensing systems based upon infrared and acoustic sensors

  3. Development of an automatic pipeline scanning system

    Kim, Jae H.; Lee, Jae C.; Moon, Soon S.; Eom, Heung S.; Choi, Yu R

    1999-11-01

    Pressure pipe inspection in nuclear power plants is one of the mandatory regulation items. Comparing to manual ultrasonic inspection, automatic inspection has the benefits of more accurate and reliable inspection results and reduction of radiation disposal. final object of this project is to develop an automatic pipeline inspection system of pressure pipe welds in nuclear power plants. We developed a pipeline scanning robot with four magnetic wheels and 2-axis manipulator for controlling ultrasonic transducers, and developed the robot control computer which controls the robot to navigate along inspection path exactly. We expect our system can contribute to reduction of inspection time, performance enhancement, and effective management of inspection results. The system developed by this project can be practically used for inspection works after field tests. (author)

  4. Rock support system development test plan

    The Test Plan has been prepared to support design activities for the development of a rock support system for a Nuclear Waste Repository in Basalt (NWRB). The rock support system is assumed to consist of a combination of shotcrete and rock bolts. The seven testing activities include mix development and physical testing of shotcrete, durability testing of shotcrete, durability testing of rock bolt grouts, field tests on rock bolts, field testing of shotcrete, and heated room test. The objective of the Test Plan is to develop required data through combined laboratory, field, and office studies for design and design validation of the rock support system. The overall Test Plan is developed to provide a logical progression from laboratory tests performed to characterize fundamental thermomechanical properties of shotcrete and grouts, to field tests on rock bolts and shotcrete, and in situ performance tests. 21 refs., 15 figs., 33 tabs

  5. The development of ZPRL digital control system

    Zero Power Reactor at Lung-Tan (ZPRL) is a small open-pool type research reactor located at Lung-Tan, Taiwan. The reactor achieved its first criticality in 1971. An analog control system has been used for almost over 20 years and the power regulating function is found gradually out of order. Therefore, we decided to develop a digital control system to replace the existing analog one. A prototype system has been developed and under on-line test now. The proposed ZPRL digital control system consists of three personal computers. These computers are used as (1) operator console, (2) data acquisition and control system, and (3) auxiliary and backup system. The operator console contains all the man-machine interface functions in the form of graphic display. The data acquisition and control system converts the analog signals into digital ones and feeds to the other two computers. The auxiliary and backup system normally emulates a strip chart recorder for the linear and logarithmic neutron powers and also acts as a transient recorder to keep the trace of the operating conditions on demand or when the reactor scrams. On-line test shows that the system does assure a satisfactory performance. It is not only as good as the analog system but also has the advantages of flexibility, testibility, and a user friendly man-machine interface. (author)

  6. The issue of contract system development

    Obalyaeva Julia, I.

    2015-09-01

    Full Text Available The role of contract system and its institutions in the national economy, the development of public procurement, the rational use of budgetary funds is explored in the paper. Dynamics of purchases in electronic trading for 2011-2014 is given. Author's vision on the problems in the formation and development institutions such as tendering and organization of interaction of participants of procurement on an electronic platform is submitted. Among the institutions of the contract system stand out: the staff, the system of institutional relations, study, planning and regulation of public procurement, unified information system. The authors suggest possible ways of increasing the efficiency of electronic platforms, the formation of a unified information system. It addresses the issue of affiliation of the bidders, its content, assesses customer actions on the part of the Federal Antimonopoly Service.

  7. Systems strategies for developing industrial microbial strains

    Lee, Sang Yup; Kim, Hyun Uk

    2015-01-01

    performance under industrial fermentation conditions. These challenges can be overcome by taking systems approaches through the use of state-of-the-art tools of systems biology, synthetic biology and evolutionary engineering in the context of industrial bioprocess. Major systems metabolic engineering......Industrial strain development requires system-wide engineering and optimization of cellular metabolism while considering industrially relevant fermentation and recovery processes. It can be conceptualized as several strategies, which may be implemented in an iterative fashion and in different...... orders. The key challenges have been the time-, cost- and labor-intensive processes of strain development owing to the difficulties in understanding complex interactions among the metabolic, gene regulatory and signaling networks at the cell level, which are collectively represented as overall system...

  8. Development of a change management system

    Parks, Cathy Bonifas

    1993-01-01

    The complexity and interdependence of software on a computer system can create a situation where a solution to one problem causes failures in dependent software. In the computer industry, software problems arise and are often solved with 'quick and dirty' solutions. But in implementing these solutions, documentation about the solution or user notification of changes is often overlooked, and new problems are frequently introduced because of insufficient review or testing. These problems increase when numerous heterogeneous systems are involved. Because of this situation, a change management system plays an integral part in the maintenance of any multisystem computing environment. At the NASA Ames Advanced Computational Facility (ACF), the Online Change Management System (OCMS) was designed and developed to manage the changes being applied to its multivendor computing environment. This paper documents the research, design, and modifications that went into the development of this change management system (CMS).

  9. Systems analysis for the development of small resource recovery systems: research and development needs. Final report

    Crnkovich, P G; Helmstetter, A J

    1980-10-01

    The technologies that should be developed to make small-scale solid waste processing facilities attractive and viable for small municipalities with solid waste between 50 and 250 tons per day are identified. Research and development needs for refuse derived fuel systems, thermal systems, and biological processes are listed. Selected research and development needs discussed for mechanical processing systems are: develop data bank for low-cost, low-energy shredder options; develop performance data for shredders applied after separation; develop data bank for Trommel performance; and identification and evaluation of low-cost materials separation equipment. Selected research and development needs discussed for thermal systems are: emission levels from solid/waste/to/energy systems; determination of the theoretical efficiencies for thermal processing systems; boiler erosion/corrosion evaluation for systems firing refuse derived fuel; optimization of feed and ash handling systems; refractory life and maintenance requirements; development of 5- to 20-TPD systems; and optimization studies of control systems for small modular incinerators. Selected research and development needs discussed for biological processing systems are: optimum design and operation to maximize gas recovery rates and investigate process configuration alternatives for anaerobic digesters.

  10. Development of Solar Powered Irrigation System

    Development of a solar powered irrigation system has been discussed in this paper. This system would be SCADA-based and quite useful in areas where there is plenty of sunshine but insufficient water to carry out farming activities, such as rubber plantation, strawberry plantation, or any plantation, that requires frequent watering. The system is powered by solar system as a renewable energy which uses solar panel module to convert Sunlight into electricity. The development and implementation of an automated SCADA controlled system that uses PLC as a controller is significant to agricultural, oil and gas monitoring and control purpose purposes. In addition, the system is powered by an intelligent solar system in which solar panel targets the radiation from the Sun. Other than that, the solar system has reduced energy cost as well as pollution. The system is equipped with four input sensors; two soil moisture sensors, two level detection sensors. Soil moisture sensor measures the humidity of the soil, whereas the level detection sensors detect the level of water in the tank. The output sides consist of two solenoid valves, which are controlled respectively by two moistures sensors

  11. Development of Solar Powered Irrigation System

    Abdelkerim, A. I.; Sami Eusuf, M. M. R.; Salami, M. J. E.; Aibinu, A.; Eusuf, M. A.

    2013-12-01

    Development of a solar powered irrigation system has been discussed in this paper. This system would be SCADA-based and quite useful in areas where there is plenty of sunshine but insufficient water to carry out farming activities, such as rubber plantation, strawberry plantation, or any plantation, that requires frequent watering. The system is powered by solar system as a renewable energy which uses solar panel module to convert Sunlight into electricity. The development and implementation of an automated SCADA controlled system that uses PLC as a controller is significant to agricultural, oil and gas monitoring and control purpose purposes. In addition, the system is powered by an intelligent solar system in which solar panel targets the radiation from the Sun. Other than that, the solar system has reduced energy cost as well as pollution. The system is equipped with four input sensors; two soil moisture sensors, two level detection sensors. Soil moisture sensor measures the humidity of the soil, whereas the level detection sensors detect the level of water in the tank. The output sides consist of two solenoid valves, which are controlled respectively by two moistures sensors.

  12. Hydrogen storage and delivery system development

    Handrock, J.L.; Wally, K.; Raber, T.N. [Sandia National Labs., Livermore, CA (United States)

    1995-09-01

    Hydrogen storage and delivery is an important element in effective hydrogen utilization for energy applications and is an important part of the FY1994-1998 Hydrogen Program Implementation Plan. The purpose of this project is to develop a platform for the engineering evaluation of hydrogen storage and delivery systems with an added focus on lightweight hydride utilization. Hybrid vehicles represent the primary application area of interest, with secondary interests including such items as existing vehicles and stationary uses. The near term goal is the demonstration of an internal combustion engine/storage/delivery subsystem. The long term goal is optimization of storage technologies for both vehicular and industrial stationary uses. In this project an integrated approach is being used to couple system operating characteristics to hardware development. A model has been developed which integrates engine and storage material characteristics into the design of hydride storage and delivery systems. By specifying engine operating parameters, as well as a variety of storage/delivery design features, hydride bed sizing calculations are completed. The model allows engineering trade-off studies to be completed on various hydride material/delivery system configurations. A more generalized model is also being developed to allow the performance characteristics of various hydrogen storage and delivery systems to be compared (liquid, activated carbon, etc.). Many of the features of the hydride storage model are applicable to the development of this more generalized model.

  13. Cryogenic Propellant Feed System Analytical Tool Development

    Lusby, Brian S.; Miranda, Bruno M.; Collins, Jacob A.

    2011-01-01

    The Propulsion Systems Branch at NASA s Lyndon B. Johnson Space Center (JSC) has developed a parametric analytical tool to address the need to rapidly predict heat leak into propellant distribution lines based on insulation type, installation technique, line supports, penetrations, and instrumentation. The Propellant Feed System Analytical Tool (PFSAT) will also determine the optimum orifice diameter for an optional thermodynamic vent system (TVS) to counteract heat leak into the feed line and ensure temperature constraints at the end of the feed line are met. PFSAT was developed primarily using Fortran 90 code because of its number crunching power and the capability to directly access real fluid property subroutines in the Reference Fluid Thermodynamic and Transport Properties (REFPROP) Database developed by NIST. A Microsoft Excel front end user interface was implemented to provide convenient portability of PFSAT among a wide variety of potential users and its ability to utilize a user-friendly graphical user interface (GUI) developed in Visual Basic for Applications (VBA). The focus of PFSAT is on-orbit reaction control systems and orbital maneuvering systems, but it may be used to predict heat leak into ground-based transfer lines as well. PFSAT is expected to be used for rapid initial design of cryogenic propellant distribution lines and thermodynamic vent systems. Once validated, PFSAT will support concept trades for a variety of cryogenic fluid transfer systems on spacecraft, including planetary landers, transfer vehicles, and propellant depots, as well as surface-based transfer systems. The details of the development of PFSAT, its user interface, and the program structure will be presented.

  14. PSSD - Planning System for Sustainable Development

    PSSD - Planning System for Sustainable Development - is a part of the Baltic Sea Region's INTERREG II C program. The current report describes some theories, methods and tools developed under the PSSD project. First, the theoretical foundation of the project is described. Secondly, the role of...... indicators in sustainable development is discussed and a Web-based indicator generator is described. Thirdly, we describe a number of methods and tools, which support planning for sustainable development. Finally, some technical interface tools - especially a Web-based interface to the methods and tools, the...

  15. Development of automated blender and dispensing system

    This paper describes automated blender and dispensing system designed and developed in Nuclear Recycle Board for its reprocessing plant. Obtaining sinterable grade oxide powder from the product solution received in the heavy metal product line involves skilled manpower and time consuming, laborious manual operations. Entire treatment is carried out in a train of closed containments called as glove boxes. In view of this Automated blender and dispensing system has been developed to reduce tedious manual operations. System consists of PLC based control system to drive motorised charging mechanism, a conical ribbon blender which homogenises the product and load cell triggered, indexing dispensing mechanism. Schematic design of the system has been done in-house, while fabrication was outsourced. System has been built, tested and installed at component test facility (CTF) at Tarapur. Actual blending tests were carried out by using dummy material like calcium carbonate and barium carbonate powder, with different sets of parameter. Blended product was chemically analysed for its homogeneity. System has now been put to trial runs by operating staff. This development has circumvented tedious operations of Scooping and increased the throughput. This paper describes challenges in undertaking this developmental work. (author)

  16. Modified projective synchronization of a fractional-order hyperchaotic system with a single driving variable

    Wang Xing-Yuan; Zhang Yong-Lei

    2011-01-01

    In this paper,the modified projective synchronization (MPS) of a fractional-order hyperchaotic system is investigated.We design the response system corresponding to the drive system on the basis of projective synchronization theory,and determine the sufficient condition for the synchronization of the drive system and the response system based on fractional-order stability theory.The MPS of a fractional-order hyperchaotic system is achieved by transmitting a single variable.This scheme reduces the information transmission in order to achieve the synchronization,and extends the applicable scope of MPS.Numerical simulations further demonstrate the feasibility and the effectiveness of the proposed scheme.

  17. Development of integrated CAD system PV-1

    An integrated CAD system for pressure vessels, such as heat exchangers, drums, towers, jacketed vessels, and tanks, has been developed. The system is operated by MS-DOS personal computers combined in a LAN. Pressure vessel designers can work watching using the computer display because the system automatically manages design work, on a common data base. The project team members in other sections, such as production, cost control, and design, have the same data concurrently. Personal computers unite the 3D CAD system, and the generated design with detail dimensions and shapes is stored in the 3D CAD system automatically. The system has promoted higher design quality and greatly reduced design cost. (author)

  18. Development of the Hypothalamic Melanocortin System

    Berengere eCoupe

    2013-03-01

    Full Text Available The melanocortin system is a critical component of the forebrain and hindbrain regulatory systems involved in energy balance. This system is composed of pro-opiomelanocortin (POMC neurons that act, in part, through the melanocortin-4 receptor (MC4R. Although the importance of the melanocortin system in controlling feeding has been established for two decades, the understanding of the developmental substrates underlying POMC and MC4R neuron development and function has just begun to emerge. The formation of the melanocortin system involves several discrete developmental steps that include the birth and fate specification of POMC- and MC4R-containing neurons and the extension and guidance of POMC axons to their MC4R-expressing target nuclei. Each of these developmental processes appears to require specific sets of genes and developmental cues that include perinatal hormones. Recent evidence has also highlighted the importance of perinatal nutrition in controlling the ultimate architecture of the melanocortin system.

  19. Groundwork for Universal Canister System Development

    Price, Laura L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Gross, Mike [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Prouty, Jeralyn L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Rigali, Mark J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Craig, Brian [Argonne National Lab. (ANL), Argonne, IL (United States); Han, Zenghu [Argonne National Lab. (ANL), Argonne, IL (United States); Lee, John Hok [Argonne National Lab. (ANL), Argonne, IL (United States); Liu, Yung [Argonne National Lab. (ANL), Argonne, IL (United States); Pope, Ron [Argonne National Lab. (ANL), Argonne, IL (United States); Connolly, Kevin [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Feldman, Matt [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Jarrell, Josh [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Radulescu, Georgeta [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Scaglione, John [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Wells, Alan [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-09-01

    The mission of the United States Department of Energy's Office of Environmental Management is to complete the safe cleanup of the environmental legacy brought about from five decades of nuclear weapons development and go vernment - sponsored nuclear energy re search. S ome of the waste s that that must be managed have be en identified as good candidates for disposal in a deep borehole in crystalline rock (SNL 2014 a). In particular, wastes that can be disposed of in a small package are good candidates for this disposal concept. A canister - based system that can be used for handling these wastes during the disposition process (i.e., storage, transfers, transportation, and disposal) could facilitate the eventual disposal of these wastes. This report provides information for a program plan for developing specifications regarding a canister - based system that facilitates small waste form packaging and disposal and that is integrated with the overall efforts of the DOE's Office of Nuclear Energy Used Fuel Dis position Camp aign's Deep Borehole Field Test . Groundwork for Universal Ca nister System Development September 2015 ii W astes to be considered as candidates for the universal canister system include capsules containing cesium and strontium currently stored in pools at the Hanford Site, cesium to be processed using elutable or nonelutable resins at the Hanford Site, and calcine waste from Idaho National Laboratory. The initial emphasis will be on disposal of the cesium and strontium capsules in a deep borehole that has been drilled into crystalline rock. Specifications for a universal canister system are derived from operational, performance, and regulatory requirements for storage, transfers, transportation, and disposal of radioactive waste. Agreements between the Department of Energy and the States of Washington and Idaho, as well as the Deep Borehole Field Test plan provide schedule requirements for development of the universal canister system

  20. Development of Constellation's Launch Control System

    Lougheed, Kirk D.; Peaden, Cary J.

    2010-01-01

    The paper focuses on the National Aeronautics and Space Administration (NASA) Constellation Program's Launch Control System (LCS) development effort at Kennedy Space Center (KSC). It provides a brief history of some preceding efforts to provide launch control and ground processing systems for other NASA programs, and some lessons learned from those experiences. It then provides high level descriptions of the LCS mission, objectives, organization, architecture, and progress. It discusses some of our development tenets, including our use of standards based design and use of off-the-shelf products whenever possible, incremental development cycles, and highly reliable, available, and supportable enterprise class system servers. It concludes with some new lessons learned and our plans for the future.

  1. Reactor alarm system development and application issues

    The new hardware and software technologies, and the need in research reactors for assistance systems in operation and maintenance, have given an appropriate background to develop a computer based system named ''Reactor Alarm System'' (RAS). RAS is a software package, user oriented, with emphasis on production, experiments and maintenance goals. It is designed to run on distributed systems conformed with microcomputers under QNX operating system. RAS main features are: a) Alarm Panel Display; b) Alarm Page; c) Alarm Masking and Inhibition; d) Alarms Color and Attributes; e) Condition Classification; and f) Arrangement Presentation. RAS design allows it to be installed as a part of a computer based Supervision and Control System in new installations or retrofit existing reactor instrumentation systems. The analysis of human factors during development stage and successive user feedback from different applications, brought out several RAS improvements: a) Multiple-copy alarm summaries; b) Improved alarm handling; c) Extended dictionary; and d) Enhanced hardware availability. It has proved successful in providing new capabilities for operators, and also has shown the continuous increase of user-demands, reflecting the expectations placed today on computer-based systems. (author). 6 figs, 1 tabs

  2. Software development methodology for high consequence systems

    Baca, L.S.; Bouchard, J.F.; Collins, E.W.; Eisenhour, M.; Neidigk, D.D.; Shortencarier, M.J.; Trellue, P.A.

    1997-10-01

    This document describes a Software Development Methodology for High Consequence Systems. A High Consequence System is a system whose failure could lead to serious injury, loss of life, destruction of valuable resources, unauthorized use, damaged reputation or loss of credibility or compromise of protected information. This methodology can be scaled for use in projects of any size and complexity and does not prescribe any specific software engineering technology. Tasks are described that ensure software is developed in a controlled environment. The effort needed to complete the tasks will vary according to the size, complexity, and risks of the project. The emphasis of this methodology is on obtaining the desired attributes for each individual High Consequence System.

  3. Development of the data acquisition system 'MORAINE'

    This publication presents the software development of the data acquisition system 'MORAINE'. The distributed multiprocessor system is designed for the spectrometer SPHERE. The system consists of three VME processor modules, specialized FASTBUS modules, three personal computers (IBM PC) type networked with local Ethernet. The software is developed for three VME processor modules. It controls the reading of event fragments into VME processor modules and uses data block transfer via direct memory access, reconstructs the events, transfers data into the local network for on-line analysis and records data on external media for OFF-line analysis. The usage of the distributed computer system allows one to duplicate the efficiency of the spectrometer due to parallel reading event fragments. (author)

  4. Hydrogen storage and delivery system development: Analysis

    Handrock, J.L. [Sandia National Labs., Livermore, CA (United States)

    1996-10-01

    Hydrogen storage and delivery is an important element in effective hydrogen utilization for energy applications and is an important part of the FY1994-1998 Hydrogen Program Implementation Plan. This project is part of the Field Work Proposal entitled Hydrogen Utilization in Internal Combustion Engines (ICE). The goal of the Hydrogen Storage and Delivery System Development Project is to expand the state-of-the-art of hydrogen storage and delivery system design and development. At the foundation of this activity is the development of both analytical and experimental evaluation platforms. These tools provide the basis for an integrated approach for coupling hydrogen storage and delivery technology to the operating characteristics of potential hydrogen energy use applications. Results of the analytical model development portion of this project will be discussed. Analytical models have been developed for internal combustion engine (ICE) hybrid and fuel cell driven vehicles. The dependence of hydride storage system weight and energy use efficiency on engine brake efficiency and exhaust temperature for ICE hybrid vehicle applications is examined. Results show that while storage system weight decreases with increasing engine brake efficiency energy use efficiency remains relatively unchanged. The development, capability, and use of a recently developed fuel cell vehicle storage system model will also be discussed. As an example of model use, power distribution and control for a simulated driving cycle is presented. Model calibration results of fuel cell fluid inlet and exit temperatures at various fuel cell idle speeds, assumed fuel cell heat capacities, and ambient temperatures are presented. The model predicts general increases in temperature with fuel cell power and differences between inlet and exit temperatures, but under predicts absolute temperature values, especially at higher power levels.

  5. A Guerilla Approach to Control System Development

    Dovc, J.; Milcinski, G; Plesko, M.

    2001-01-01

    We present our experiences in managing the development cycles of the control systems for ANKA and the ALMA Common Software. Our team consists practically only of undergraduate students. Stimulating and rewarding the students with cutting-edge technologies and travel to conferences like this and installation fieldwork are an important positive factor in raising their motivation. However, building any system with a group of inexperienced students is quite a challenging task. Many problems occur...

  6. Intrinsic Motivation Systems for Autonomous Mental Development

    Oudeyer, Pierre-Yves; Kaplan, Frederic; Hafner, Verena

    2007-01-01

    Exploratory activities seem to be intrinsically rewarding for children and crucial for their cognitive development. Can a machine be endowed with such an intrinsic motivation system? This is the question we study in this paper, presenting a number of computational systems that try to capture this drive towards novel or curious situations. After discussing related research coming from developmental psychology, neuroscience, developmental robotics, and active learning, this paper prese...

  7. System development and asset management under restructuring

    In many developed countries the electricity infrastructure contains ageing assets. Because of the need of a continuing operation and higher load factors on the network, the opportunities for replacement or refurbishment are limited. These must be regarded as an opportunity to review the structure of the system and to consider the design and development required to meet the new requirements, taking advantage of new available technologies: HVDC, FACTS, cables, etc. The symposium examines assets management issues and assesses strategies for overhauling existing systems, taking into account the impact on market operation, on supply security and environment

  8. Development of an automatic reactor inspection system

    Using recent technologies on a mobile robot computer science, we developed an automatic inspection system for weld lines of the reactor vessel. The ultrasonic inspection of the reactor pressure vessel is currently performed by commercialized robot manipulators. Since, however, the conventional fixed type robot manipulator is very huge, heavy and expensive, it needs long inspection time and is hard to handle and maintain. In order to resolve these problems, we developed a new automatic inspection system using a small mobile robot crawling on the vertical wall of the reactor vessel. According to our conceptual design, we developed the reactor inspection system including an underwater inspection robot, a laser position control subsystem, an ultrasonic data acquisition/analysis subsystem and a main control subsystem. We successfully carried out underwater experiments on the reactor vessel mockup, and real reactor ready for Ulchine nuclear power plant unit 6 at Dusan Heavy Industry in Korea. After this project, we have a plan to commercialize our inspection system. Using this system, we can expect much reduction of the inspection time, performance enhancement, automatic management of inspection history, etc. In the economic point of view, we can also expect import substitution more than 4 million dollars. The established essential technologies for intelligent control and automation are expected to be synthetically applied to the automation of similar systems in nuclear power plants

  9. Some problems in large superconducting system development

    The experience in developments of large superconducting magnetic systems (SMS) for investigations into controlled fusion, accumulated in the Kurchatov Institute of Atomic Energy, is analyzed. The early operating SMS of the immersion and circulation type are described. The specifications of SMS being developed are presented. The advantages of circulation-type devices over the immersion-type ones are demostrated. The prospects for use of SMS on multistrand intermetallic materials are briefly outlined

  10. Development of materials supply system requirements

    Brynning, Nicklas; Kihlström, Joakim

    2010-01-01

    In industry today, the need for excellent product development and realization in many different aspects is increasing. This calls for excellent quality, while at the same time time-to-market is increasingly important. A concurrent engineering (CE) approach is directed towards simultaneously developing different aspects of product realization in order to enhance both quality and speed. This thesis deals with the internal materials supply system (MSS) from a CE approach. Logistics aspects are o...

  11. Development of KSTAR Neutral Beam Heating System

    Oh, B. H.; Song, W. S.; Yoon, B. J. (and others)

    2007-10-15

    The prototype components of a neutral beam injection (NBI) system have been developed for the KSTAR, and a capability of the manufactured components has been tested. High power ion source, acceleration power supply, other ion source power supplies, neutralizer, bending magnet for ion beam separation, calorimeter, and cryo-sorption pump have been developed by using the domestic technologies and tested for a neutral beam injection of 8 MW per beamline with a pulse duration of 300 seconds. The developed components have been continuously upgraded to achieve the design requirements. The development technology of high power and long pulse neutral beam injection system has been proved with the achievement of 5.2 MW output for a short pulse length and 1.6 MW output for a pulse length of 300 seconds. Using these development technologies, the domestic NB technology has been stabilized under the development of high power ion source, NB beamline components, high voltage and current power supplies, NB diagnostics, NB system operation and control.

  12. Development of automatic laser welding system

    Laser are a new production tool for high speed and low distortion welding and applications to automatic welding lines are increasing. IHI has long experience of laser processing for the preservation of nuclear power plants, welding of airplane engines and so on. Moreover, YAG laser oscillators and various kinds of hardware have been developed for laser welding and automation. Combining these welding technologies and laser hardware technologies produce the automatic laser welding system. In this paper, the component technologies are described, including combined optics intended to improve welding stability, laser oscillators, monitoring system, seam tracking system and so on. (author)

  13. Development of intelligent supervisory control system

    The objective of the development of an intelligent supervisory control system for next generation plants is enhancement of the operational reliability by applying the recent outcome of artificial intelligence and computer technologies. This system consists of the supervisory control and monitoring for automatic operation, the equipment operation support for historical data management and for test scheduling, the operators' decision making support for accidental plant situations and the human-friendly interface of these support functions. The verification test results showed the validity of the functions realized by this system for the next generation control room. (author)

  14. Development and implementation of integrated management system

    Risk Engineering Ltd is a private Bulgarian company in the field of scientific technical consultancy and engineering services, established in 1990. The aim of this report is to present the experience of Risk Engineering Ltd. in the development, implementation and operation of an integrated management system. The process of implementation of the system was completed at the end of 2011. In January 2012, the Risk Engineering Integrated Management System was certified by Lloyd's Register for compliance with standards ISO 9001:2008, ISO 140001:2004 and BS OHSAS 18001:2007

  15. Telerobotic work system: Concept development and evolution

    Jenkins, Lyle M.

    1987-01-01

    The basic concept of a telerobotic work system (TWS) consists of two dexterous manipulator arms controlled from a remote station. The term telerobotic describes a system that is a combination of teleoperator control and robotic operation. Work represents the function of producing physical changes. System describes the integration of components and subsystems to effectively accomplish the needed mission. Telerobotics reduces exposure to hazards for flight crewmembers and increases their productivity. The requirements for the TWS are derived from both the mission needs and the functional capabilities of existing hardware and software to meet those needs. The development of the TWS is discussed.

  16. Developing stereo image based robot control system

    Suprijadi,; Pambudi, I. R.; Woran, M.; Naa, C. F; Srigutomo, W. [Department of Physics, FMIPA, InstitutTeknologi Bandung Jl. Ganesha No. 10. Bandung 40132, Indonesia supri@fi.itb.ac.id (Indonesia)

    2015-04-16

    Application of image processing is developed in various field and purposes. In the last decade, image based system increase rapidly with the increasing of hardware and microprocessor performance. Many fields of science and technology were used this methods especially in medicine and instrumentation. New technique on stereovision to give a 3-dimension image or movie is very interesting, but not many applications in control system. Stereo image has pixel disparity information that is not existed in single image. In this research, we proposed a new method in wheel robot control system using stereovision. The result shows robot automatically moves based on stereovision captures.

  17. Developing stereo image based robot control system

    Application of image processing is developed in various field and purposes. In the last decade, image based system increase rapidly with the increasing of hardware and microprocessor performance. Many fields of science and technology were used this methods especially in medicine and instrumentation. New technique on stereovision to give a 3-dimension image or movie is very interesting, but not many applications in control system. Stereo image has pixel disparity information that is not existed in single image. In this research, we proposed a new method in wheel robot control system using stereovision. The result shows robot automatically moves based on stereovision captures

  18. Development of a thermoluminescent personnel monitoring system

    Thermoluminescent personnel monitoring system has been developed by the Division of Radiological Protection, Bhabha Atomic Research Centre (BARC), Bombay. The system is presently in use for estimation of personnel doses of radiation workers of BARC, other units of the Department of Atomic Energy, and Defence medical units in India. The report gives salient features of the TLD personnel monitoring system. The report discusses design considerations of thermoluminescent dosimetry (TLD) badge for measurement of X and β;, γ personnel exposures, a filter combination to compensate for energy dependence of the TLD disc and angular dependence of the badge. The badge reader incorporates a semiautomatic mechanical arrangement wherein the TLD cards are read, raising the heater after positioning the TLD discs one by one. Various figures illustrate the mechanical layouts and electronics circuits used in the system. Periodic quality assurance check of the system which ensures a good reproducibility, is also described. (author)

  19. Dynamics of mononuclear phagocyte system Fc receptor function in systemic lupus erythematosus. Relation to disease activity and circulating immune complexes.

    Kimberly, R P; Parris, T M; Inman, R D; McDougal, J S

    1983-02-01

    Seventeen pairs of longitudinal studies of mononuclear phagocyte system (MPS) Fc receptor function in 15 patients with systemic lupus were performed to explore the dynamic range of Fc receptor dysfunction in lupus and to establish the relationships between MPS function, clinical disease activity and circulating immune complexes (CIC). Fc receptor function was measured by the clearance of IgG sensitized autologous erythrocytes. At the time of first study the degree of MPS dysfunction was correlated with both clinical activity (P less than 0.05) and CIC (P less than 0.05). At follow-up patients with a change in clinical status show significantly larger changes in clearance function compared to clinically stable patients (206 min vs 7 min; P less than 0.001). MPS function changed concordantly with a change in clinical status in all cases (P = 0.002). Longitudinal assessments did not demonstrate concordance of changes in MPS function and CIC, measured by three different assays. The MPS Fc receptor defect in systemic lupus is dynamic and closely associated with disease activity. The lack of concordance of the defect with changes in CIC suggests that either CIC does not adequately reflect receptor site saturation or that other factors may also contribute to the magnitude of MPS dysfunction. PMID:6839542

  20. Development of Human System Integration at NASA

    Whitmore, Mihriban; McGuire, Kerry; Thompson, Shelby; Vos, Gordon

    2012-01-01

    Human Systems Integration seeks to design systems around the capabilities and limitations of the humans which use and interact with the system, ensuring greater efficiency of use, reduced error rates, and less rework in the design, manufacturing and operational deployment of hardware and software. One of the primary goals of HSI is to get the human factors practitioner involved early in the design process. In doing so, the aim is to reduce future budget costs and resources in redesign and training. By the preliminary design phase of a project nearly 80% of the total cost of the project is locked in. Potential design changes recommended by evaluations past this point will have little effect due to lack of funding or a huge cost in terms of resources to make changes. Three key concepts define an effective HSI program. First, systems are comprised of hardware, software, and the human, all of which operate within an environment. Too often, engineers and developers fail to consider the human capacity or requirements as part of the system. This leads to poor task allocation within the system. To promote ideal task allocation, it is critical that the human element be considered early in system development. Poor design, or designs that do not adequately consider the human component, could negatively affect physical or mental performance, as well as, social behavior. Second, successful HSI depends upon integration and collaboration of all the domains that represent acquisition efforts. Too often, these domains exist as independent disciplines due to the location of expertise within the service structure. Proper implementation of HSI through participation would help to integrate these domains and disciplines to leverage and apply their interdependencies to attain an optimal design. Via this process domain interests can be integrated to perform effective HSI through trade-offs and collaboration. This provides a common basis upon which to make knowledgeable decisions. Finally

  1. The Systems Theory Framework of Career Development

    McMahon, Mary

    2011-01-01

    The Systems Theory Framework (STF; McMahon & Patton, 1995; Patton & McMahon, 2006) of career development was proposed as a metatheoretical framework that accommodates the contribution of all theories and offers an integrative and coherent framework of career influences. In this article, the author provides an overview of the STF, outlines its…

  2. Developing a solar panel testing system

    Árpád Rácz

    2009-10-01

    Full Text Available Solar energy is increasingly used togenerate electricity for individual households. There isa wide variety of solar panel technologies, whichshould be tested at an individual level during theirlifetime. In this paper, the development of a testingstation at the University of Debrecen is presented. Thetesting system can be used for research andeducational purposes and for in field applicationsequally well.

  3. Development of China Digital Seismological Observational Systems

    刘瑞丰; 吴忠良; 阴朝民; 陈运泰; 庄灿涛

    2003-01-01

    Development of China Digital Seismological Observational Systems during 1996~2000 and the Capital Circle Area Seismograph Network during 1999~2001 are introduced, and the station distributions, instruments used, main tasks of National Digital Seismograph Network, Regional Digital Seismograph Network and Portable Digital Seismograph Network are introduced chiefly.

  4. Teaching Information Systems Development via Process Variants

    Tan, Wee-Kek; Tan, Chuan-Hoo

    2010-01-01

    Acquiring the knowledge to assemble an integrated Information System (IS) development process that is tailored to the specific needs of a project has become increasingly important. It is therefore necessary for educators to impart to students this crucial skill. However, Situational Method Engineering (SME) is an inherently complex process that…

  5. Developing a Package Training System for Industry

    Battersby, D. L. N.

    1974-01-01

    The hotel and catering industry is one of Great Britain's largest. A packaged training system has been developed to satisfy the needs of this industry, an ever-growing occupational field with multiple categories. The material provided in each package outlines short pieces of instruction and helps the trainer create appropriate training. (DS)

  6. Developing aircraft photonic networks for airplane systems

    White, Henry J.; Brownjohn, Nick; Baptista, João;

    2013-01-01

    Achieving affordable high speed fiber optic communication networks for airplane systems has proved to be challenging. In this paper we describe a summary of the EU Framework 7 project DAPHNE (Developing Aircraft Photonic Networks). DAPHNE aimed to exploit photonic technology from terrestrial...

  7. Redesigning Health Information Systems in Developing Countries

    Mengiste, Shegaw Anagaw; Kimaro, Honest; Aanestad, Margunn

    2008-01-01

    Despite widespread aims to strengthen the Health Information System (HIS) as a tool for decentralised health care, there is a strong tendency in most developing countries that the HIS continues to reflect the central level's needs and requirements. The traditional design approach with little or no...

  8. Recent developments of the ALPI control system

    This paper presents recent developments of the control system for ALPI, the new superconducting linear accelerator that will begin to operate at L.N.L. next year. Both hardware and software architectures are described and some base choices are discussed. Results of tests performed in the last two years are also reported. (author)

  9. MPACT Fast Neutron Multiplicity System Prototype Development

    D.L. Chichester; S.A. Pozzi; J.L. Dolan; M.T. Kinlaw; S.J. Thompson; A.C. Kaplan; M. Flaska; A. Enqvist; J.T. Johnson; S.M. Watson

    2013-09-01

    This document serves as both an FY2103 End-of-Year and End-of-Project report on efforts that resulted in the design of a prototype fast neutron multiplicity counter leveraged upon the findings of previous project efforts. The prototype design includes 32 liquid scintillator detectors with cubic volumes 7.62 cm in dimension configured into 4 stacked rings of 8 detectors. Detector signal collection for the system is handled with a pair of Struck Innovative Systeme 16-channel digitizers controlled by in-house developed software with built-in multiplicity analysis algorithms. Initial testing and familiarization of the currently obtained prototype components is underway, however full prototype construction is required for further optimization. Monte Carlo models of the prototype system were performed to estimate die-away and efficiency values. Analysis of these models resulted in the development of a software package capable of determining the effects of nearest-neighbor rejection methods for elimination of detector cross talk. A parameter study was performed using previously developed analytical methods for the estimation of assay mass variance for use as a figure-of-merit for system performance. A software package was developed to automate these calculations and ensure accuracy. The results of the parameter study show that the prototype fast neutron multiplicity counter design is very nearly optimized under the restraints of the parameter space.

  10. Development of Arduino based wireless control system

    Sun, Zhuoxiong; Dyke, Shirley J.; Pena, Francisco; Wilbee, Alana

    2015-03-01

    Over the past few decades, considerable attention has been given to structural control systems to mitigate structural vibration under natural hazards such as earthquakes and extreme weather conditions. Traditional wired structural control systems often employ a large amount of cables for communication among sensors, controllers and actuators. In such systems, implementation of wired sensors is usually quite complicated and expensive, especially on large scale structures such as bridges and buildings. To reduce the laborious installation and maintenance cost, wireless control systems (WCSs) are considered as a novel approach for structural vibration control. In this work, a WCS is developed based on the open source Arduino platform. Low cost, low power wireless sensing and communication components are built on the Arduino platform. Structural control algorithms are embedded within the wireless sensor board for feedback control. The developed WCS is first validated through a series of tests. Next, numerical simulations are performed simulating wireless control of a 3-story shear structure equipped with a semi-active control device (MR damper). Finally, experimental studies are carried out implementing the WCS on the 3-story shear structure in the Intelligent Infrastructure Systems Lab (IISL). A hydraulic shake table is used to generate seismic ground motions. The control performance is evaluated with the impact of modeling uncertainties, measurement noises as well as time delay and data loss induced by the wireless network. The developed WCS is shown to be effective in controlling structural vibrations under several historical earthquake ground motions.

  11. Development of an advanced robot manipulator system

    A sophisticated manipulator system for an advanced robot was developed under the 'Advanced Robot Technology Development' Program promoted and supported by the Agency of Industrial Science and Technology of MITI. The authors have participated in the development of a fingered manipulator with force and tactile sensors applicable to a masterslave robot system. Our slave manipulator is equipped with four fingers. Though the finger needs many degrees of freedom so as to be suitable for skilful handing of an object, our fingers are designed to have minimum degree of freedom in order to reduce weight. Each finger tip was designed to be similar to a human finger which has flexibility, softness and contact feeling. The shape of the master finger manipulator was so designed that the movement of the fingers is smoother and that the constraint feeling of the operator is smaller. We were adopted to a pneumatic pressure system for transmitting the tactile feeling of the slave fingers to the master fingers. A multiple sensory bilateral control system which gives an operator a feeling of force and tactile reduces his feeling of constraint in carrying out work with a robot system. (author)

  12. Advanced Turbine Systems Program industrial system concept development

    Gates, S. [Solar Turbines Inc., San Diego, CA (United States)

    1995-10-01

    The objective of Phase II of the Advanced Turbine Systems Program is to develop conceptual designs of gas fired advanced turbine systems that can be adapted for operation on coal and biomass fuels. The technical, economic, and environmental performance operating on natural gas and in a coal fueled mode is to be assessed. Detailed designs and test work relating to critical components are to be completed and a market study is to be conducted.

  13. Development of radiation detection and measurement systems

    Moon, B. S.; Ham, C. S.; Chung, C. E. and others

    2000-03-01

    This report contains descriptions on the following six items. The first item is the result of a study on CsI(TI) crystals with their light emitting characteristics and the result of a study on plastic scintillators. The second item is the result of a study on advanced radiation detectors and includes experiments for the effect of using a Compton suppressor with an HPGe detector. For the third item, we describe the results of a design work done using EGS4 for a thickness gauge, a density gauge, and a level gauge. The fourth item contains descriptions on the prototype circuit systems developed for a level gauge, a thickness gauge, and for a survey meter. The fifth part contains the computed tomography algorithm and a prototype scanning system developed for a CT system. As the sixth and the last item, we describe the prototype high precision heat source and the prototype heat-voltage converter which we have designed and fabricated.

  14. Implementing Life Cycle Assessment in systems development

    Bhander, Gurbakhash Singh; Hauschild, Michael Zwicky; McAloone, Timothy Charles

    2003-01-01

    derived from products and system, and calculate resource consumptions. However, the complexity of LCA poses restrictions to its use in current product and system development given the need for a reduction in product development cycle time which is needed to meet the increasing competitive pressures and...... discusses a number of possibilities which can be introduced in the design stage compared to the other life cycle stages of the product system. The paper collects experiences and ideas around the state-of-the-art in eco-design, from literature and personal experience and further provides eco-design life...... cycle assessment strategies. The paper reviews the current environmental evaluation practices with respect to product life cycles. As a number of deficiencies in LCA are identified, strategies are presented to provide a solution to many of the deficiencies. The result of the paper is a definition of the...

  15. Solid oxide fuel cell power system development

    Kerr, Rick [Delphi Automotive Systems, LLC., Troy, MI (United States); Wall, Mark [Independent Energy Partners Technology, LLC., Parker, CO (United States); Sullivan, Neal [Colorado School of Mines, Golden, CO (United States)

    2015-06-26

    This report summarizes the progress made during this contractual period in achieving the goal of developing the solid oxide fuel cell (SOFC) cell and stack technology to be suitable for use in highly-efficient, economically-competitive, commercially deployed electrical power systems. Progress was made in further understanding cell and stack degradation mechanisms in order to increase stack reliability toward achieving a 4+ year lifetime, in cost reduction developments to meet the SECA stack cost target of $175/kW (in 2007 dollars), and in operating the SOFC technology in a multi-stack system in a real-world environment to understand the requirements for reliably designing and operating a large, stationary power system.

  16. Development of radiation detection and measurement systems

    This report contains descriptions on the following six items. The first item is the result of a study on CsI(TI) crystals with their light emitting characteristics and the result of a study on plastic scintillators. The second item is the result of a study on advanced radiation detectors and includes experiments for the effect of using a Compton suppressor with an HPGe detector. For the third item, we describe the results of a design work done using EGS4 for a thickness gauge, a density gauge, and a level gauge. The fourth item contains descriptions on the prototype circuit systems developed for a level gauge, a thickness gauge, and for a survey meter. The fifth part contains the computed tomography algorithm and a prototype scanning system developed for a CT system. As the sixth and the last item, we describe the prototype high precision heat source and the prototype heat-voltage converter which we have designed and fabricated

  17. Development of technical information processing systems

    The major goal of this project is to develop a more efficient information management system by connecting the KAREI serials database which enable the users to access from their own laboratory facilities through KAREI-NET. The importance of this project is to make the serials information of KAERI easily accessible to users as valuable resources for R and D activities. The results of the project are as follows. 1) Development of the serials database and retrieval system enabled us to access to the serials holding information through KAERI-NET. 2) The database construction establishes a foundation for the management of 1,600 serials held in KAERI. 3) The system can be applied not only to KAERI but also to similar medium-level libraries. (Author)

  18. Development of vehicle intelligent monitoring system (VIMS)

    Fujino, Yozo; Kitagawa, Keisuke; Furukawa, Takashi; Ishii, Hironori

    2005-05-01

    In an urban highway network system such as Tokyo Metropolitan Expressway, to detect conditions of road pavement and expansion joints is a very important issue. Although accurate surface condition can be captured by using a road profiler system, the operating cost is expensive and development of a simpler and more inexpensive system is really needed to reduce monitoring cost. "Vehicle Intelligent Monitoring System (VIMS)" developed for this purpose is described in this paper. An accelerometer and GPS are installed to an ordinary road patrol car. GPS together with a PC computer are used to measure the road surface condition and to identify the location of the vehicle, respectively. Dynamic response of the vehicle is used as a measure of the road pavements surface condition as well as the expansion joints. A prototype of VIMS is installed to a motor car and measurement is made at the actual roads. Accuracy of measuring result and effectiveness of this system are demonstrated; the outline of the system and some of the measurement results are reported herein.

  19. Development of a Universal Waste Management System

    Stapleton, Thomas J.; Baccus, Shelley; Broyan, James L., Jr.

    2013-01-01

    NASA is working with a number of commercial companies to develop the next low Earth orbit spacecraft. The hardware volume and weight constraints are similar to or greater than those of the Apollo era. This, coupled with the equally demanding cost challenge of the proposed commercial vehicles, causes much of the Environmental Control and Life Support System (ECLSS) designs to be reconsidered. The Waste Collection System (WCS) is within this group of ECLSS hardware. The development to support this new initiative is discussed within. A WCS concept - intended to be common for all the vehicle platforms currently on the drawing board - is being developed. The new concept, referred to as the Universal Waste Management System (UWMS), includes favorable features from previous designs while improving on other areas on previous Space Shuttle and the existing International Space Station (ISS) WCS hardware, as needed. The intent is to build a commode that requires less crew time, improved cleanliness, and a 75% reduction in volume and weight compared to the previous US ISS/Extended Duration Orbitor WCS developed in the 1990s. The UWMS is most similar to the ISS Development Test Objective (DTO) WCS design. It is understood that the most dramatic cost reduction opportunity occurs at the beginning of the design process. To realize this opportunity, the cost of each similar component between the UWMS and the DTO WCS was determined. The comparison outlined were the design changes that would result with the greatest impact. The changes resulted in simplifying the approach or eliminating components completely. This initial UWMS paper will describe the system layout approach and a few key features of major components. Future papers will describe the UWMS functionality, test results, and components as they are developed.

  20. J-2X Abort System Development

    Santi, Louis M.; Butas, John P.; Aguilar, Robert B.; Sowers, Thomas S.

    2008-01-01

    The J-2X is an expendable liquid hydrogen (LH2)/liquid oxygen (LOX) gas generator cycle rocket engine that is currently being designed as the primary upper stage propulsion element for the new NASA Ares vehicle family. The J-2X engine will contain abort logic that functions as an integral component of the Ares vehicle abort system. This system is responsible for detecting and responding to conditions indicative of impending Loss of Mission (LOM), Loss of Vehicle (LOV), and/or catastrophic Loss of Crew (LOC) failure events. As an earth orbit ascent phase engine, the J-2X is a high power density propulsion element with non-negligible risk of fast propagation rate failures that can quickly lead to LOM, LOV, and/or LOC events. Aggressive reliability requirements for manned Ares missions and the risk of fast propagating J-2X failures dictate the need for on-engine abort condition monitoring and autonomous response capability as well as traditional abort agents such as the vehicle computer, flight crew, and ground control not located on the engine. This paper describes the baseline J-2X abort subsystem concept of operations, as well as the development process for this subsystem. A strategy that leverages heritage system experience and responds to an evolving engine design as well as J-2X specific test data to support abort system development is described. The utilization of performance and failure simulation models to support abort system sensor selection, failure detectability and discrimination studies, decision threshold definition, and abort system performance verification and validation is outlined. The basis for abort false positive and false negative performance constraints is described. Development challenges associated with information shortfalls in the design cycle, abort condition coverage and response assessment, engine-vehicle interface definition, and abort system performance verification and validation are also discussed.

  1. Thermal Protection System (Heat Shield) Development - Advanced Development Project

    Kowal, T. John

    2010-01-01

    The Orion Thermal Protection System (TPS) ADP was a 3 1/2 year effort to develop ablative TPS materials for the Orion crew capsule. The ADP was motivated by the lack of available ablative TPS's. The TPS ADP pursued a competitive phased development strategy with succeeding rounds of development, testing and down selections. The Project raised the technology readiness level (TRL) of 8 different TPS materials from 5 different commercial vendors, eventual down selecting to a single material system for the Orion heat shield. In addition to providing a heat shield material and design for Orion on time and on budget, the Project accomplished the following: 1) Re-invigorated TPS industry & re-established a NASA competency to respond to future TPS needs; 2) Identified a potentially catastrophic problem with the planned MSL heat shield, and provided a viable, high TRL alternate heat shield design option; and 3) Transferred mature heat shield material and design options to the commercial space industry, including TPS technology information for the SpaceX Dragon capsule.

  2. IDEAL: A methology for developing information systems

    Evers, Ken H.; Bachert, Robert F.

    1988-01-01

    As a result of improved capabilities obtained through current computer technologies, application programs and expert systems, Enterprises are being designed or upgraded to be highly integrated and automated information systems. To design or modify Enterprises, it is necessary to first define what functions are to be performed within the Enterprise, identify which functions are potential candidates for automation, and what automated or expert systems are available, or must be developed, to accomplish the selected function. Second, it is necessary to define and analyze the informational requirements for each function along with the informational relationships among the functions so that a database structure can be established to support the Enterprise. To perform this type of system design, an integrated set of analysis tools is required to support the information analysis process. The IDEAL (Integrated Design and Engineering Analysis Languages) methodology provides this integrated set of tools and is discussed.

  3. Development of ITER fuel cycle systems

    Korea is contributing to the construction of ITER by participating in the fields of fuel cycle and test blanket module. The authors introduce the overall concept of the ITER tritium systems and the current status of the development of the storage and delivery systems and the test blanket module. Especially the authors present the standard operating procedure of the storage and delivery system. The operating procedure consists of nine operating modes including an initial fuel loading, a fuel supply and circulation during a plasma operation, an in bed calorimetric measurement and others. authors also present the major components of the tritium extraction and purification system and the preliminary design concept for the Korean helium cooled solid breeder TBM

  4. Developing 360 degree feedback system for KINS

    Han, In Soo; Cheon, B. M.; Kim, T. H.; Ryu, J. H. [Chungman National Univ., Daejeon (Korea, Republic of)

    2003-12-15

    This project aims to investigate the feasibility of a 360 degree feedback systems for KINS and to design guiding rules and structures in implementing that systems. Literature survey, environmental analysis and questionnaire survey were made to ensure that 360 degree feedback is the right tool to improve performance in KINS. That review leads to conclusion that more readiness and careful feasibility review are needed before implementation of 360 degree feedback in KINS. Further the project suggests some guiding rules that can be helpful for successful implementation of that system in KINS. Those include : start with development, experiment with one department, tie it to a clear organization's goal, train everyone involve, make sure to try that system in an atmosphere of trust.

  5. APS storage ring vacuum system development

    The Advanced Photon Source synchrotron radiation facility, under construction at the Argonne National Laboratory, incorporates a large ring for the storage of 7 GeV positrons for the generation of photon beams for the facility's materials research program. The Storage Ring's 1104 m circumference is divided into 40 sectors which contain vacuum, beam transport, control, rf and insertion device systems. The vacuum system will operate at a pressure of 1 nTorr and is fabricated from aluminum. The system includes distributed NeG pumping, photon absorbers with lumped pumping, beam position monitors, vacuum diagnostics and valving. An overview of the vacuum system design and details of selected development program results are presented. 5 refs

  6. Enhancing System Realisation in Formal Model Development

    Tran-Jørgensen, Peter Würtz Vinther

    2016-01-01

    Software for mission-critical systems is sometimes analysed using formal specification to increase the chances of the system behaving as intended. When sufficient insights into the system have been obtained from the formal analysis, the formal specification is realised in the form of a software...... implementation. One way to realise the system’s software is by automatically generating it from the formal specification – a technique referred to as code generation. However, in general it is difficult to make guarantees about the correctness of the generated code – especially while requiring automation of the...... steps involved in realising the formal specification. This PhD dissertation investigates ways to improve the automation of the steps involved in realising and validating a system based on a formal specification. The approach aims to develop properly designed software tools which support the integration...

  7. Developing 360 degree feedback system for KINS

    This project aims to investigate the feasibility of a 360 degree feedback systems for KINS and to design guiding rules and structures in implementing that systems. Literature survey, environmental analysis and questionnaire survey were made to ensure that 360 degree feedback is the right tool to improve performance in KINS. That review leads to conclusion that more readiness and careful feasibility review are needed before implementation of 360 degree feedback in KINS. Further the project suggests some guiding rules that can be helpful for successful implementation of that system in KINS. Those include : start with development, experiment with one department, tie it to a clear organization's goal, train everyone involve, make sure to try that system in an atmosphere of trust

  8. Life support system development in West Germany.

    Skoog, A I

    1982-12-01

    The delivery of fully qualified Environmental Control and Life Support System (ECLS) flight hardware for the Spacelab Flight Unit was completed in 1979, and the first Spacelab flight is scheduled for mid 1983. With Spacelab approaching its operational stage, ESA has initiated the Follow-on Development Programme. The future evolution of Spacelab elements in a continued U.S./European cooperation is obviously linked to the U.S. STS evolution and leads from the sortie-mode improvements (Initial Step) towards pallet systems and module applications in unmanned and manned space platforms (Medium and Far Term Alternatives). Extensive studies and design work have been accomplished on life support systems for Life Sciences Laboratories (Biorack) in Spacelab (incubators and holding units for low vertebrates). Future long term missions require the implementation of closed loop life support systems and in order to meet the long range development cycle feasibility studies have been performed. Terrestrial applications of the life support technologies developed for space have been successfully implemented. PMID:11541695

  9. Development of multifunctional energy systems (MESs)

    Cai, Ruixian; Jin, Hongguang; Gao, Lin; Hong, Hui [Institute of Engineering Thermophysics, Chinese Academy of Sciences, P.O. Box 2706, Beijing 100080 (China)

    2010-11-15

    By synthetically combining the utilization of different fuels and the co-production of alternative fuels and power, a multifunctional energy system (MES) can present more opportunities to achieve higher efficiency, lower investment, and less environmental impact as compared to traditional energy systems. The principle for the integration of MES is systematically illuminated from the perspective of chemical conversion, energy utilization, and pollutants control. According to system integration characteristics, the development of MES has been classified into three stages, namely, polygeneration systems, MESs combining different fossil fuels, and MESs combining fossil fuel and renewable energy. Three MESs with primary energy savings (PESs) of 14-18% are introduced, which illustrated the potential of MES technology. At the same time, the increment of investment cost had been indicated as the major possible barriers for development of MES technology. On the basis of a comparison with other technical routes, super-critical power plants, and IGCC technology, the role of the MES in the sustainable development of China has been established. (author)

  10. HELIAS module development for systems codes

    In order to study and design next-step fusion devices such as DEMO, comprehensive systems codes are commonly employed. In this work HELIAS-specific models are proposed which are designed to be compatible with systems codes. The subsequently developed models include: a geometry model based on Fourier coefficients which can represent the complex 3-D plasma shape, a basic island divertor model which assumes diffusive cross-field transport and high radiation at the X-point, and a coil model which combines scaling aspects based on the HELIAS 5-B reactor design in combination with analytic inductance and field calculations. In addition, stellarator-specific plasma transport is discussed. A strategy is proposed which employs a predictive confinement time scaling derived from 1-D neoclassical and 3-D turbulence simulations. This paper reports on the progress of the development of the stellarator-specific models while an implementation and verification study within an existing systems code will be presented in a separate work. This approach is investigated to ultimately allow one to conduct stellarator system studies, develop design points of HELIAS burning plasma devices, and to facilitate a direct comparison between tokamak and stellarator DEMO and power plant designs

  11. Life support system development in West Germany

    Skoog, A. Ingemar

    The delivery of fully qualified Environmental Control and Life Support System (ECLS) flight hardware for the Spacelab Flight Unit was completed in 1979, and the first Spacelab flight is scheduled for mid 1983. With Spacelab approaching its operational stage, ESA has initiated the Follow-on Development Programme. The future evolution of Spacelab elements in a continued U.S./European cooperation is obviously linked to the U.S. STS evolution and leads from the sortie-mode improvements (Initial Step) towards pallet systems and module applications in unmanned and manned space platforms (Medium and Far Term Alternatives). Extensive studies and design work have been accomplished on life support systems for Life Sciences Laboratories (Biorack) in Spacelab (incubators and holding units for low vertebrates). Future long term missions require the implementation of closed loop life support systems and in order to meet the long range development cycle feasibility studies have been performed. Terrestrial applications of the life support technologies developed for space have been successfully implemented.

  12. HELIAS module development for systems codes

    Warmer, F., E-mail: Felix.Warmer@ipp.mpg.de; Beidler, C.D.; Dinklage, A.; Egorov, K.; Feng, Y.; Geiger, J.; Schauer, F.; Turkin, Y.; Wolf, R.; Xanthopoulos, P.

    2015-02-15

    In order to study and design next-step fusion devices such as DEMO, comprehensive systems codes are commonly employed. In this work HELIAS-specific models are proposed which are designed to be compatible with systems codes. The subsequently developed models include: a geometry model based on Fourier coefficients which can represent the complex 3-D plasma shape, a basic island divertor model which assumes diffusive cross-field transport and high radiation at the X-point, and a coil model which combines scaling aspects based on the HELIAS 5-B reactor design in combination with analytic inductance and field calculations. In addition, stellarator-specific plasma transport is discussed. A strategy is proposed which employs a predictive confinement time scaling derived from 1-D neoclassical and 3-D turbulence simulations. This paper reports on the progress of the development of the stellarator-specific models while an implementation and verification study within an existing systems code will be presented in a separate work. This approach is investigated to ultimately allow one to conduct stellarator system studies, develop design points of HELIAS burning plasma devices, and to facilitate a direct comparison between tokamak and stellarator DEMO and power plant designs.

  13. Requirements development for a patient computing system.

    Wald, J S; Pedraza, L A; Reilly, C A; Murphy, M E; Kuperman, G J

    2001-01-01

    Critical parts of the software development life cycle are concerned with eliciting, understanding, and managing requirements. Though the literature on this subject dates back for several decades, practicing effective requirements development remains a current and challenging area. Some projects flourish with a requirements development process (RDP) that is implicit and informal, but this approach may be overly risky, particularly for large projects that involve multiple individuals, groups, and systems over time. At Partners HealthCare System in Boston, Massachusetts, we have applied a more formal approach for requirements development to the Patient Computing Project. The goal of the project is to create web-based software that connects patients electronically with their physician's offices and has the potential to improve care efficiency and quality. It is a large project, with over 500 function points. Like most technological innovation, the successful introduction of this system requires as much attention to understanding the business needs and workflow details as it does to technical design and implementation. This paper describes our RDP approach, and key business requirements discovered through this process. We believe that a formal RDP is essential, and that informatics as a field must include proficiencies in this area. PMID:11825282

  14. Offshore Wind Energy Systems Engineering Curriculum Development

    McGowan, Jon G. [Univ. of Massachusetts, Amherst, MA (United States); Manwell, James F. [Univ. of Massachusetts, Amherst, MA (United States); Lackner, Matthew A. [Univ. of Massachusetts, Amherst, MA (United States)

    2012-12-31

    Utility-scale electricity produced from offshore wind farms has the potential to contribute significantly to the energy production of the United States. In order for the U.S. to rapidly develop these abundant resources, knowledgeable scientists and engineers with sound understanding of offshore wind energy systems are critical. This report summarizes the development of an upper-level engineering course in "Offshore Wind Energy Systems Engineering." This course is designed to provide students with a comprehensive knowledge of both the technical challenges of offshore wind energy and the practical regulatory, permitting, and planning aspects of developing offshore wind farms in the U.S. This course was offered on a pilot basis in 2011 at the University of Massachusetts and the National Renewable Energy Laboratory (NREL), TU Delft, and GL Garrad Hassan have reviewed its content. As summarized in this report, the course consists of 17 separate topic areas emphasizing appropriate engineering fundamentals as well as development, planning, and regulatory issues. In addition to the course summary, the report gives the details of a public Internet site where references and related course material can be obtained. This course will fill a pressing need for the education and training of the U.S. workforce in this critically important area. Fundamentally, this course will be unique due to two attributes: an emphasis on the engineering and technical aspects of offshore wind energy systems, and a focus on offshore wind energy issues specific to the United States.

  15. Development of the Medium Energy Linac Systems

    The main purpose of this project is developing 100-MeV proton linear accelerator (linac) for proton engineering frontier project (PEFP). In the first phase of the PEFP, the development of the 20-MeV linac has successfully finished. Hence the work scope of this project is designing the linac to accelerate proton beams from 20-MeV up to 100-MeV, fabricating the linac up to 45 MeV, fabricating one set of the medium energy beam transport (MEBT) tank, and developing the low level radio frequency (LLRF) system and the control system. The basic role of the new proton accelerator is accelerating 20-mA proton beams from 20 MeV up to 100 MeV. The first step of the design procedure is optimizing and determining the accelerator parameters. The beam loss is also main concern in the design stage. The drift tube (DT) and the quadrupole magnets are designed to be optimized to the new linac design. The other purpose is confirming the new design by fabricating and tuning the drift tube linac (DTL). The 20MeV proton beam divided into two directions. One is supplying the beams to user group by turning on the 45-degree bending magnet. The other is guided into the 100-MeV DTL by tuning off the dipole magnet. That is why the PEFP MEBT located after 20-MeV DTL. The MEBT is realized as two small DTL tanks with three cells and a 45-degree bending magnet. The fabrication of one MEBT tank is another purpose of this project. The other purposes of this project is developing the LLRF system to control the RF signal and control system to monitor and control the vacuum system, magnet power supply, etc

  16. Development of FBR cycle data base system

    In the 'Feasibility Study on Commercialized Fast Reactor Cycle System (F/S)'. scenario evaluations, cost-benefit evaluations and system characteristic evaluations to show significance of the Fast Breeder Reactor (FBR) cycle system introduction concretely are performed in parallel with a design study for FBR plants, reprocessing systems and fabrication systems. In these evaluations, informations such as economic prospects, prospects for supply and demand of resources and a progress of engineering development are used in addition to design information. This report explains a FBR Cycle Database in order to carry out management and search of various design information and the relating information. The prototype system of the database was completed in the 2000 fiscal year, and the problem of the user number restriction of the prototype system has been improved by Web-ization in the 2001 fiscal year. About 7,000 data are stored in this data base (as of the end of March, 2002). The expansion of user etc., and the continuation of input work of various evaluation information will be carried out, in the phase 2 of F/S. (author)

  17. Sensor Development for PEM Fuel Cell Systems

    Steve Magee; Richard Gehman

    2005-07-12

    This document reports on the work done by Honeywell Sensing and Control to investigate the feasibility of modifying low cost Commercial Sensors for use inside a PEM Fuel Cell environment. Both stationary and automotive systems were considered. The target environment is hotter (100 C) than the typical commercial sensor maximum of 70 C. It is also far more humid (100% RH condensing) than the more typical 95% RH non-condensing at 40 C (4% RH maximum at 100 C). The work focused on four types of sensors, Temperature, Pressure, Air Flow and Relative Humidity. Initial design goals were established using a market research technique called Market Driven Product Definition (MDPD). A series of interviews were conducted with various users and system designers in their facilities. The interviewing team was trained in data taking and analysis per the MDPD process. The final result was a prioritized and weighted list of both requirements and desires for each sensor. Work proceeded on concept development for the 4 types of sensors. At the same time, users were developing the actual fuel cell systems and gaining knowledge and experience in the use of sensors and controls systems. This resulted in changes to requirements and desires that were not anticipated during the MDPD process. The concepts developed met all the predicted requirements. At the completion of concept development for the Pressure Sensor, it was determined that the Fuel Cell developers were happy with off-the-shelf automotive pressure sensors. Thus, there was no incentive to bring a new Fuel Cell Specific Pressure Sensor into production. Work was therefore suspended. After the experience with the Pressure Sensor, the requirements for a Temperature Sensor were reviewed and a similar situation applied. Commercially available temperature sensors were adequate and cost effective and so the program was not continued from the Concept into the Design Phase.

  18. ARM System Developer's Guide Designing and Optimizing System Software

    Sloss, Andrew

    2004-01-01

    Over the last ten years, the ARM architecture has become one of the most pervasive architectures in the world, with more than 2 billion ARM-based processors embedded in products ranging from cell phones to automotive braking systems. A world-wide community of ARM developers in semiconductor and product design companies includes software developers, system designers and hardware engineers. To date no book has directly addressed their need to develop the system and software for an ARM-based system. This text fills that gap. This book provides a comprehensive description of the operation of the ARM core from a developer's perspective with a clear emphasis on software. It demonstrates not only how to write efficient ARM software in C and assembly but also how to optimize code. Example code throughout the book can be integrated into commercial products or used as templates to enable quick creation of productive software. The book covers both the ARM and Thumb instruction sets, covers Intel''s XScale Processors, ou...

  19. Development of evaluation system for flashing erosion

    Liquid droplet impingement erosion (LDI) is defined as an erosion phenomenon caused by high-speed droplet attack in a wet steam flow, and sometimes observed in a steam piping system of a power plant. In our previous researches, we have developed an LDI evaluation system to evaluate the thinning shape due to LDI on a steam piping within a practically acceptable time. However, present system is not applicable to LDI on a hot-water piping due to flashing phenomena (flashing erosion) because it is difficult to calculate the flashing flow due to sudden phase change and critical flow rate evaluation models needed for LDI evaluation system are not verified in wet steam region. Therefore, in this study, we tried to develop a new flow calculation code for flashing flow and to verify the critical flow rate evaluation models in wet steam region. For flashing flow simulation, based on a present CFD code, pre-conditioning method was adopted to achieve the stable calculation of the water region, and extended look-up table including from low-pressure water to high-pressure dry steam was incorporated. Finally, a new CFD code water-steam flow was developed. Several benchmark tests were conducted and those results show this new code can reproduce the flashing phenomena and is applicable from the very low-speed flow to supersonic flow. Then, HEM model for critical mass flow rate was verified with flashing and wet steam experiments and CFD calculations, and incorporated into LDI evaluation system to extend applicable region of the evaluation system into flashing erosion. (author)

  20. Oral health care systems in developing and developed countries

    Kandelman, Daniel; Arpin, Sophie; Baez, Ramon J;

    2012-01-01

    Health care systems are essential for promoting, improving and maintaining health of the population. Through an efficient health service, patients can be advised of disease that may be present and so facilitate treatment; risks factors whose modification could reduce the incidence of disease...... and illness in the future can be identified, and further, how controlling such factors can contribute to maintain a good quality of life. In developed countries, clinics or hospitals may be supported by health professionals from various specialties that allow their cooperation to benefit the patient......; these institutions or clinics may be equipped with the latest technical facilities. In developing countries, health services are mostly directed to provide emergency care only or interventions towards certain age group population. The most common diseases are dental caries and periodontal disease and frequently...

  1. Equipment system for advanced nuclear fuel development

    The purpose of the settlement of equipment system for nuclear Fuel Technology Development Facility(FTDF) is to build a seismic designed facility that can accommodate handling of nuclear materials including <20% enriched Uranium and produce HANARO fuel commercially, and also to establish the advanced common research equipment essential for the research on advanced fuel development. For this purpose, this research works were performed for the settlement of radiation protection system and facility special equipment for the FTDF, and the advanced common research equipment for the fuel fabrication and research. As a result, 11 kinds of radiation protection systems such as criticality detection and alarm system, 5 kinds of facility special equipment such as environmental pollution protection system and 5 kinds of common research equipment such as electron-beam welding machine were established. By the settlement of exclusive domestic facility for the research of advanced fuel, the fabrication and supply of HANARO fuel is possible and also can export KAERI-invented centrifugal dispersion fuel materials and its technology to the nations having research reactors in operation. For the future, the utilization of the facility will be expanded to universities, industries and other research institutes

  2. Systems strategies for developing industrial microbial strains.

    Lee, Sang Yup; Kim, Hyun Uk

    2015-10-01

    Industrial strain development requires system-wide engineering and optimization of cellular metabolism while considering industrially relevant fermentation and recovery processes. It can be conceptualized as several strategies, which may be implemented in an iterative fashion and in different orders. The key challenges have been the time-, cost- and labor-intensive processes of strain development owing to the difficulties in understanding complex interactions among the metabolic, gene regulatory and signaling networks at the cell level, which are collectively represented as overall system performance under industrial fermentation conditions. These challenges can be overcome by taking systems approaches through the use of state-of-the-art tools of systems biology, synthetic biology and evolutionary engineering in the context of industrial bioprocess. Major systems metabolic engineering achievements in recent years include microbial production of amino acids (L-valine, L-threonine, L-lysine and L-arginine), bulk chemicals (1,4-butanediol, 1,4-diaminobutane, 1,5-diaminopentane, 1,3-propanediol, butanol, isobutanol and succinic acid) and drugs (artemisinin). PMID:26448090

  3. Development of A Plant Navigation System

    A 'Plant Navigation System (PNS)' is under development to assist nuclear power plant (NPP) operators by automatically displaying the plant situation and plant operational procedures on a CRT screen when abnormalities occur. The operation procedures given in a symptom-oriented manual are expressed in a tree - type flowchart (modified PAD). The optimum operation procedure for an NPP is selected automatically using built-in diagnostic logics based on the current status of the NPP. Concerning the plant situation, the PNS displays important information only on the current status of the NPP. A prototype PNS system is being constructed. (authors)

  4. Diesel starting system monitor: Prototype development

    The US Department of Energy (DOE) effort to extend the operational lives of commercial nuclear power plants is examining methods for predicting the performance of specific equipment. This paper focuses on predictive monitoring as a means for reducing equipment surveillance, maintenance, and outages. Realizing these goals will result in nuclear plants that are more reliable, have lower maintenance costs, and have longer lives. This report describes a prognostic monitoring system that has been developed to predict starting performance in emergency diesels. A prototype system has been built and tested on an engine at Sandia National Laboratories. 6 refs., 8 figs

  5. Optimal Control Development System for Electrical Drives

    Marian GAICEANU; Emil ROSU; Romeo PADURARU; Cristinel DACHE

    2008-01-01

    In this paper the optimal electrical drive development system is presented. It consists of both electrical drive types: DC and AC. In order to implement the optimal control for AC drive system an Altivar 71 inverter, a Frato magnetic particle brake (as load), three-phase induction machine, and dSpace 1104 controller have been used. The on-line solution of the matrix Riccati differential equation (MRDE) is computed by dSpace 1104 controller, based on the corresponding feedback signals, generat...

  6. Scaling Health Information Systems in Developing Countries

    Mengiste, Shegaw Anagaw; Neilsen, Petter

    2006-01-01

    This article addresses the issues of scaling health information system in the context of developing countries by taking a case study from Ethiopia. Concepts of information infrastructure have been used as an analytical lens to better understand scaling of Health Information systems. More...... specifically, we question the fruitfulness of focusing on not being installed base hostile and suggest focusing on how to be installed base “friendly” by underscoring how the installed base can also be draw upon and shaped by human agents. The paper conceptualizes health information infrastructure (HII...

  7. [Development of Hospital Equipment Maintenance Information System].

    Zhou, Zhixin

    2015-11-01

    Hospital equipment maintenance information system plays an important role in improving medical treatment quality and efficiency. By requirement analysis of hospital equipment maintenance, the system function diagram is drawed. According to analysis of input and output data, tables and reports in connection with equipment maintenance process, relationships between entity and attribute is found out, and E-R diagram is drawed and relational database table is established. Software development should meet actual process requirement of maintenance and have a friendly user interface and flexible operation. The software can analyze failure cause by statistical analysis. PMID:27066680

  8. Development and Implementation of Sepsis Alert Systems.

    Harrison, Andrew M; Gajic, Ognjen; Pickering, Brian W; Herasevich, Vitaly

    2016-06-01

    Development and implementation of sepsis alert systems is challenging, particularly outside the monitored intensive care unit (ICU) setting. Barriers to wider use of sepsis alerts include evolving clinical definitions of sepsis, information overload, and alert fatigue, due to suboptimal alert performance. Outside the ICU, barriers include differences in health care delivery models, charting behaviors, and availability of electronic data. Current evidence does not support routine use of sepsis alert systems in clinical practice. Continuous improvement in the afferent and efferent aspects will help translate theoretic advantages into measurable patient benefit. PMID:27229639

  9. Risk management in information system development

    Ristola, Teemu

    2011-01-01

    The purpose of this study is to facilitate the implementation process of the case corporation’s new information system for managing their inventory of bus tires. This study attempts to answer the questions “What were the main IT-risks in-volved with the development and implementation of the new bus tire inventory management system, what kind of effects did they have and how were they dealt with”. The study was carried out with the cooperation of the case corporation, Koiviston Auto, as a part...

  10. Development of clean chemical mechanical polishing systems; Clean CMP system

    Tsujimura, M.; Hosokawa, M. [Ebara Corp., Tokyo (Japan)

    1998-10-20

    Described herein are clean chemical mechanical polishing (CMP) systems developed by Ebara. A CMP system needs advanced peripheral techniques, in addition to those for grinding adopted by the conventional system, in order to fully exhibit its inherent functions. An integrated design concept is essential for the CMP steps, including slurry supplying, polishing, washing, process controlling and waste fluid treatment. The Ebara has adopted a standard concept `Clean CMP, dry-in and dry-out of wafers,` and provided world`s highest grades of techniques for inter-layer insulating film, shallow trench isolation, plug and wiring. The head for the polishing module is specially designed by FEM, to improve homogeneity of wafers from the center to edges. The dresser is also specially designed, to improve pad surface topolody after dressing. A slurry dipsersing method is developed to reduce slurry consumption. Various washing modules, designed to have the same external shape, can be allocated to various functions. 10 figs.

  11. Space Launch System Accelerated Booster Development Cycle

    Arockiam, Nicole; Whittecar, William; Edwards, Stephen

    2012-01-01

    With the retirement of the Space Shuttle, NASA is seeking to reinvigorate the national space program and recapture the public s interest in human space exploration by developing missions to the Moon, near-earth asteroids, Lagrange points, Mars, and beyond. The would-be successor to the Space Shuttle, NASA s Constellation Program, planned to take humans back to the Moon by 2020, but due to budgetary constraints was cancelled in 2010 in search of a more "affordable, sustainable, and realistic" concept2. Following a number of studies, the much anticipated Space Launch System (SLS) was unveiled in September of 2011. The SLS core architecture consists of a cryogenic first stage with five Space Shuttle Main Engines (SSMEs), and a cryogenic second stage using a new J-2X engine3. The baseline configuration employs two 5-segment solid rocket boosters to achieve a 70 metric ton payload capability, but a new, more capable booster system will be required to attain the goal of 130 metric tons to orbit. To this end, NASA s Marshall Space Flight Center recently released a NASA Research Announcement (NRA) entitled "Space Launch System (SLS) Advanced Booster Engineering Demonstration and/or Risk Reduction." The increased emphasis on affordability is evident in the language used in the NRA, which is focused on risk reduction "leading to an affordable Advanced Booster that meets the evolved capabilities of SLS" and "enabling competition" to "enhance SLS affordability. The purpose of the work presented in this paper is to perform an independent assessment of the elements that make up an affordable and realistic path forward for the SLS booster system, utilizing advanced design methods and technology evaluation techniques. The goal is to identify elements that will enable a more sustainable development program by exploring the trade space of heavy lift booster systems and focusing on affordability, operability, and reliability at the system and subsystem levels5. For this study

  12. Development of severe accident training support system

    In order for appropriate decision-making during plant operation and management, the professional knowledge, expert's opinion, and previous experiences as well as information for current status are utilized. The operation support systems such as training simulators have been developed to assist these decision-making process, and most of them cover from normal operation to emergency operation because of the very low frequency of severe accident and of uncertaintics included in severe accident phenomena and scenarios. However, the architectures for severe accident management are being established based on severe accident management guidelines in some developed countries. Recentrly, in Korea, as teh severe accident management guideline was developed, the basis for establishing severe accident management architecture is prepared and this leads to the development of tool for systematic education and training for personnel related to severe accident management. The severe accident taining support system thus is developed to assist decision-making during execution of severe accident management guidelines by providing plant status information, prefessional knowledge for phenomena and scenarios, expected behavior for strategy execution, and so on

  13. Development of in-situ monitoring system

    Development of in-situ monitoring system using an optical fiber to measure the real time temperature variation of subsurface water for the evaluation of flow characteristics. We describe the feasibility of developing a fiber-optic temperature sensor using a thermochromic material. A sensor-tip is fabricated by mixing of a thermochromic material powder. The relationships between the temperatures and the output voltages of detectors are determined to measure the temperature of water. It is expected that the fiber-optic temperature monitoring sensor using thermochromic material can be used to measure the real time temperature variation of subsurface water

  14. Development of technical information processing system (VII)

    The goal of this project is to establish integrated environment focused on enhanced information services to researchers through the providing of acquisition information, key phrase retrieval function, journal content information linked with various subsystems already developed. The results of the project are as follows. 1. It is possible to serve information on unreceivable materials among required materials throughout the system. 2. Retrieval efficiency is increased by the adding of key phrase retrieval function. 3. Rapidity of information service is enhanced by the providing of journal contents of each issue received and work performance of contents service is become higher. 4. It is possible to acquire, store, serve technical information needed in R and D synthetically and systematically throughout the development of total system linked with various subsystems required to technical information management and service. 21 refs. (Author)

  15. Development of NMCA system and software

    Full text: Development of the NMCA system in the Institute of Atomic Energy is described. The Institute is the one of research scientific subdivisions of the National Nuclear Center of the Republic of Kazakhstan. Four nuclear facilities in the country is operating. Institute is a facility with two research reactors, located on the remote sites of the former Semipalatinsk nuclear test site. Layouts and main parameters of the reactors are attached. In additional to reactors, NM storages, on-pile stands, research labs and hot cell are located on sites. The NM storing and handling are covered by NMCA system which after USSR disintegration was in a bad condition: on-paper account, lack of personal training, normative documents, measuring system, and access control. After ratification of Safeguards Agreement all Kazakhstan's nuclear facilities became to being inspected by IAEA and State authority. Putting of the NMCA system according to international rules is started. Since 1993 a collaboration with Departments of Defense and Energy is begun, particularly with Los-Alamos, Sandia and Oak-Ridge National labs. Directions of development and needs of technical and methodical assistance were defined. In the following time a computers for account, spectrometric and weighing equipment for NDA, TID and other office equipment were delivered. Development of a number of documents concerning regulation of NM handling, IAEA inspectors cooperation, reporting was conducted under ORNL support. NMCA custodians were participants of many training courses held in Kazakhstan, NIS, LANL, NRC. The computerized NMCA system 'AIMAS' developed in ANL and delivered to the Institute was implemented successfully in 1995. During some followed years the 'AIMAS' system was modified step by step and spread to other nuclear facilities of Kazakhstan and Uzbekistan under DOE support. The important element of supporting of SSAC development in Kazakhstan is funding and providing with methodic of annual

  16. INTEGRATED HSEQ MANAGEMENT SYSTEMS: DEVELOPMENTS AND TRENDS

    Osmo Kauppila

    2015-06-01

    Full Text Available The integration of health and safety, environmental and quality (HSEQ management systems has become a current topic in the 21st century, as the need for systems thinking has grown along with the number of management system standards. This study aims to map current developments and trends in integrated HSEQ management. Three viewpoints are taken: the current state of the main HSEQ management standards, research literature on integrated management systems (IMS, and a case study of an industry-led HSEQ cluster in Northern Finland. The results demonstrate that some of the most prominent current trends are the harmonization of the high level structure of management systems by ISO, the evaluation of IMS, accounting for the supply chain in HSEQ issues, and sustainability and risk management. The results of the study can be used by practitioners to get a view of the current state of HSEQ management systems and their integration, and by researchers to seek out potential directions for HSEQ and IMS related research.

  17. Development of cask and transportation system

    Transportation of spent fuels to the AFR interim storage facility and disposal repository are necessary in Korea. Therefore, an emphasis has been concentrated to develop the design and fabrication technology of commercial casks. A conceptual design of the temperature and deformation measuring systems in the cask, which will be used for mock-up tests has been performed. Preliminary design data of the cask for 7 spent PWR fuels have been obtained in the course of study. (author)

  18. StreamingBandit: Developing Adaptive Persuasive Systems

    Kaptein, Maurits; Kruijswijk, Jules

    2016-01-01

    This paper introduces StreamingBandit, a (back-end) solution for developing adaptive and personalized persuasive systems. Creating successful persuasive applications requires a combination of design, social science, and technology. StreamingBandit contributes to the required technology by providing a platform that can be used to adapt persuasive technologies in real-time and at large scales. We first introduce the design philosophy of StreamingBandit using a running example and highlight how ...

  19. Developing digital control for aquaponic system

    REPŠE, MATIC

    2015-01-01

    The goal of the thesis is to show the development and implementation process of hardware and software solution for controlling and managing Aquaponics systems, which are responsible for simultaneous production of animal protein (fish) and plants. In the thesis, we described what Aquaponics consists of, where is our attention mostly needed and the problems we have to deal with. We also added a short explanation of the possible corresponding approach to a solution. Hereafter, we presented ou...

  20. Breeder reactor fuel fabrication system development

    Significant progress has been made in the design and development of remotely operated breeder reactor fuel fabrication and support systems (e.g., analytical chemistry). These activities are focused by the Secure Automated Fabrication (SAF) Program sponsored by the Department of Energy to provide: a reliable supply of fuel pins to support US liquid metal cooled breeder reactors and at the same time demonstrate the fabrication of mixed uranium/plutonium fuel by remotely operated and automated methods

  1. Developing innovative systems for reinforced masonry walls

    Mosele, F.; Porto, F. da; Modena, C.; Fusco, A. di; Cesare, G. di; Vasconcelos, Graça; Haach, V.; Lourenço, Paulo B.; Beer, I; Schmidt, U.; Brameshuber, W.; Scheufler, W.; Schermer, D. C.; Zilch, K.

    2006-01-01

    The Commission of the European Communities has recently funded a CRAFT research project aimed at developing innovative systems for load and non-load-bearing reinforced masonry walls. The project involves twelve partners coming from four different European countries, among which there are universities and research centres, small and medium enterprises for the production of clay and concrete units and mortars, a company for advanced metal products and industrial associations of brick and block ...

  2. Low cost attitude control system scanwheel development

    Bialke, William; Selby, Vaughn

    1991-01-01

    In order to satisfy a growing demand for low cost attitude control systems for small spacecraft, development of low cost scanning horizon sensor coupled to a low cost/low power consumption Reaction Wheel Assembly was initiated. This report addresses the details of the versatile design resulting from this effort. Tradeoff analyses for each of the major components are included, as well as test data from an engineering prototype of the hardware.

  3. Systems Medicine in Pharmaceutical Research and Development.

    Kuepfer, Lars; Schuppert, Andreas

    2016-01-01

    The development of new drug therapies requires substantial and ever increasing investments from the pharmaceutical company. Ten years ago, the average time from early target identification and optimization until initial market authorization of a new drug compound took more than 10 years and involved costs in the order of one billion US dollars. Recent studies indicate even a significant growth of costs in the meanwhile, mainly driven by the increasing complexity of diseases addressed by pharmaceutical research.Modeling and simulation are proven approaches to handle highly complex systems; hence, systems medicine is expected to control the spiral of complexity of diseases and increasing costs. Today, the main focus of systems medicine applications in industry is on mechanistic modeling. Biological mechanisms are represented by explicit equations enabling insight into the cooperation of all relevant mechanisms. Mechanistic modeling is widely accepted in pharmacokinetics, but prediction from cell behavior to patients is rarely possible due to lacks in our understanding of the controlling mechanisms. Data-driven modeling aims to compensate these lacks by the use of advanced statistical and machine learning methods. Future progress in pharmaceutical research and development will require integrated hybrid modeling technologies allowing realization of the benefits of both mechanistic and data-driven modeling. In this chapter, we sketch typical industrial application areas for both modeling techniques and derive the requirements for future technology development. PMID:26677181

  4. NWAS. Developments for passive uranium assay system

    We developed uranium mass assay systems for 200-litter wastes drums applied neutron and gamma measurements by NDA method. The systems are composed of the 16 pieces of Helium-3 proportional counters for neutron detection with 100mm thickness polyethylene and a Ge-SSD for gamma ray detection. The neutron measurement methodology is consist of U-234 (α,n) reaction and gamma measurement is applied by Ge-SSD. The extensive testing trials using the known amount of uranium with different enrichment and some kinds of matrices in drums were performed. By using this system we tried to determine uranium mass in drums for the purpose of reduction MUF in URCP. (author)

  5. LSD (Landing System Development) Impact Simulation

    Ullio, R.; Riva, N.; Pellegrino, P.; Deloo, P.

    2012-07-01

    In the frame of the Exploration Programs, a soft landing on the planet surface is foreseen. To ensure a successful final landing phase, a landing system by using leg tripod design landing legs with adequate crushable damping system was selected, capable of absorbing the residual velocities (vertical, horizontal and angular) at touch- down, insuring stability. TAS-I developed a numerical non linear dynamic methodology for the landing impact simulation of the Lander system by using a commercial explicit finite element analysis code (i.e. Altair RADIOSS). In this paper the most significant FE modeling approaches and results of the analytical simulation of landing impact are reported, especially with respect to the definition of leg dimensioning loads and the design update of selected parts (if necessary).

  6. Optimal Control Development System for Electrical Drives

    Marian GAICEANU

    2008-08-01

    Full Text Available In this paper the optimal electrical drive development system is presented. It consists of both electrical drive types: DC and AC. In order to implement the optimal control for AC drive system an Altivar 71 inverter, a Frato magnetic particle brake (as load, three-phase induction machine, and dSpace 1104 controller have been used. The on-line solution of the matrix Riccati differential equation (MRDE is computed by dSpace 1104 controller, based on the corresponding feedback signals, generating the optimal speed reference for the AC drive system. The optimal speed reference is tracked by Altivar 71 inverter, conducting to energy reduction in AC drive. The classical control (consisting of rotor field oriented control with PI controllers and the optimal one have been implemented by designing an adequate ControlDesk interface. The three-phase induction machine (IM is controlled at constant flux. Therefore, the linear dynamic mathematical model of the IM has been obtained. The optimal control law provides transient regimes with minimal energy consumption. The obtained solution by integration of the MRDE is orientated towards the numerical implementation-by using a zero order hold. The development system is very useful for researchers, doctoral students or experts training in electrical drive. The experimental results are shown.

  7. Solar Energy Forecast System Development and Implementation

    Jascourt, S. D.; Kirk-Davidoff, D. B.; Cassidy, C.

    2012-12-01

    Forecast systems for predicting real-time solar energy generation are being developed along similar lines to those of more established wind forecast systems, but the challenges and constraints are different. Clouds and aerosols play a large role, and for tilted photovoltaic panels and solar concentrating plants, the direct beam irradiance, which typically has much larger forecast errors than global horizontal irradiance, must be utilized. At MDA Information Systems, we are developing a forecast system based on first principles, with the well-validated REST2 clear sky model (Gueymard, 2008) at its backbone. In tuning the model and addressing aerosol scattering and surface albedo, etc., we relied upon the wealth of public data sources including AERONET (aerosol optical depth at different wavelengths), Suominet (GPS integrated water vapor), NREL MIDC solar monitoring stations, SURFRAD (includes upwelling shortwave), and MODIS (albedo in different wavelength bands), among others. The forecast itself utilizes a blend of NWP model output, which must be brought down to finer time resolution based on the diurnal cycle rather than simple interpolation. Many models currently do not output the direct beam irradiance, and one that does appears to have a bias relative to its global horizontal irradiance, with equally good performance attained by utilizing REST2 and the model global radiation to estimate the direct component. We will present a detailed assessment of various NWP solar energy products, evaluating forecast skill at a range of photovoltaic installations.

  8. System Transfer, Education, and Development in Mozambique

    Jose Cossa

    2011-03-01

    Full Text Available In this study the author used conceptual historical method to assess the phenomenon of system transfer and the association between education and development in Mozambique. The assessment was administered through critical analysis of documents pertaining to the Salazar (1924-1966, Machel (1975-1986, and Chissano (1986-2005 administrations. The findings were that (a the colonial government created economic and educational systems for colonizing Mozambique, whereas the Machel and Chissano administrations adapted foreign systems of government and education (i.e., Socialism, Soviet, Democracy, Portuguese, etc., to their particular context without altering the inherent theoretical basis of the systems transferred; (b the Machel and Chissano administrations, implicitly or explicitly, perceived the relationship between education and development as circular causality rather than a unidirectional linear causality, while the Salazar administration perceived it as unidirectional linear causality; and (c while the Machel and Chissano administrations focused on primary education, literacy campaigns, and education of women and girls, they differed in the reasons for such focus.

  9. Development of decommissioning engineering support system for fugen. Development of support system during actual dismantlement works

    The Advanced Thermal Reactor, Fugen Nuclear Power Station was permanently shut down in March 2003, and is now preparing for decommissioning. We have been developing Decommissioning Engineering Support System (DEXUS) aimed at planning optimal dismantlement process and carrying out dismantlement work safely and precisely. DEXUS consists of 'decommissioning planning support system' and 'dismantling support system'. The dismantling support system is developed aiming at using during actual dismantling work. It consists of three subsystems such as 'Worksite Visualization System', 'Dismantling Data Collection System' and 'Generated Waste Management System'. 'Worksite Visualization System' is a support system designed to provide the necessary information to workers during actual dismantlement works. And this system adopts AR (Augmented Reality) technology, overlapping calculation information into real world. 'Dismantling Data Collection System' is to collect necessary data for improving accuracy of decommissioning planning by evaluating work content and worker equipage, work time for dismantlement works. 'Generated Waste Management system' is a system recording necessary information by attaching the barcode to dismantled wastes or the containers. We can get the information of generated waste by recording generation place, generated time, treatment method and the contents. These subsystems enable to carry out reasonable and safe decommissioning of Fugen. In addition, we expect that those systems will be used for decommissioning of other nuclear facilities in the future. (authors)

  10. Development of an intellectual maintenance management system. Development of trouble detection and troubleshooting evaluation system

    Many research activities are conducted to enhance cost performance and safety of nuclear power plants operation and maintenance. Concept of autonomous operating system to equal the role of operators and of maintenance personnel with artificial intelligence and autonomous robots has been developed. An intellectual maintenance management system has been developed to be equipped with decision making functions of maintenance personnel. The intellectual maintenance management system is in charge of maintenance function of an autonomous plant, which consists of plant-wide monitoring, evaluation of component integrity, and scheduling of maintenance activities. In other words, this system should be equipped with preventive maintenance and corrective maintenance functions those are currently loaded on personnel. In this report, we discussed condition monitoring maintenance in the preventive maintenance. We also reported a sensor validation system development for machinery condition monitoring and diagnosis. We adopted distributed and cooperative system construction technique, which is expected recently in applications to large-scale plants. This system has inter-agent communication function for signal transmission and reception among distributed physics models of machineries. The system has been constructed for water/steam system of the LMFBR power plant. The system has been validated to be capable of cooperative sensor validation by the distributed set of agents, with quantitative indication of sensor deviation based on a newly developed fuzzy algorithm with inter-agent cooperation. The derived reference parameter value from the inter-agent evaluations also stands for the alternative measurement to the malfunctioned sensor. (author)

  11. Quantum phase transitions about parity breaking in matrix product systems

    ZHU Jing-Min

    2011-01-01

    According to our scheme to construct quantum phase transitions (QPTs) in spin chain systems with matrix product ground states, we first successfully combine matrix product state (MPS) QPTs with spontaneous symmetry breaking. For a concrete model, we take into account a kind of MPS QPTs accompanied by spontaneous parity breaking, though for either side of the critical point the GS is typically unique, and show that the kind of MPS QPTs occur only in the thermodynamic limit and are accompanied by the appearance of singularities, diverging correlation length, vanishing energy gap and the entanglement entropy of a half-infinite chain not only staying finite but also whose first derivative discontinuous.

  12. Cognitive development in patients with Mucopolysaccharidosis type III (Sanfilippo syndrome)

    Colland Vivian; Grootenhuis Martha; Marchal Jan; Valstar Marlies J; Wijburg Frits A

    2011-01-01

    Abstract Background Mucopolysaccharidosis type III (MPS III, Sanfilippo syndrome) is a lysosomal storage disorder caused by a deficiency of one of the enzymes involved in the degradation of heparan sulfate. MPS III is characterized by progressive mental deterioration resulting in severe dementia. A number of potentially disease-modifying therapies are studied. As preservation of cognitive function is the ultimate goal of treatment, assessment of cognitive development will be essential in orde...

  13. Development of the Medium Energy Linac Systems

    The main purposes of the proton engineering frontier project is developing a proton linac which accelerates 20 mA proton beams up to 100 MeV and supplying 20 MeV and 100 MeV proton beams to the user groups. The project 'Development of the medium energy linac systems' is aiming to design the 100 MeV proton linac, to construct an accelerating cavity, to design a MEBT system, and to develop a energy measurement system. The 100 MeV linac consists of 20 DTL tanks which are operated by five additional klystrons. The focusing lattice is FFDD as the 20 MeV DTL. However the hollow conductors are used for coils of the quadrupole magnets. The shape of the drift tubes in the new tanks is changed to compensate the reduction of the accelerating efficiency in the high energy region. For example, the face angle of drift tubes begins at 40 degrees. The bore radius is selected as 10 mm in order to eliminate beam loss in the beam line. We can obtain the 100 MeV proton beams by using these accelerating structure. We have designed some of the tanks in detail. It covers the modification of the structure by including the stem, post-coupler, and sulg-tuner effects, the error analysis, the thermal and structure analysis, the drift tube design, the magnet design, the various ports design, the support structure design, the end-plate design, etc. Now the first DTL tank is constructed by a local company. An beam extraction system is essential after 20 MeV DTL in order to supply 20 MeV proton beams. Since there are no focusing elements in the structure, the beam should be spread out. The MEBT which consists of two 3-cell DTL tanks is designed to control the beam size in the beam extraction system by magnets in the first tank and to transversely match the beam into the next DTL by magnets in the the second tank. The longitudinal matching is done by the RF in both tanks. We have also developed an energy measurement system using the time of flight method

  14. Maximum Potential Score (MPS): An operating model for a successful customer-focused strategy.

    Cabello González, José Manuel; Galguera, Laura; Ruiz de la Rúa, Francisco

    2015-01-01

    One of marketers’ chief objectives is to achieve customer loyalty, which is a key factor for profitable growth. Therefore, they need to develop a strategy that attracts and maintains customers, giving them adequate motives, both tangible (prices and promotions) and intangible (personalized service and treatment), to satisfy a customer and make him loyal to the company. Finding a way to accurately measure satisfaction and customer loyalty is very important. With regard to typical Relationship ...

  15. Development of Vertical Cable Seismic System (2)

    Asakawa, E.; Murakami, F.; Tsukahara, H.; Ishikawa, K.

    2012-12-01

    The vertical cable seismic is one of the reflection seismic methods. It uses hydrophone arrays vertically moored from the seafloor to record acoustic waves generated by surface, deep-towed or ocean bottom sources. Analyzing the reflections from the sub-seabed, we could look into the subsurface structure. This type of survey is generally called VCS (Vertical Cable Seismic). Because VCS is an efficient high-resolution 3D seismic survey method for a spatially-bounded area, we proposed the method for the hydrothermal deposit survey tool development program that the Ministry of Education, Culture, Sports, Science and Technology (MEXT) started in 2009. We are now developing a VCS system, including not only data acquisition hardware but data processing and analysis technique. Our first experiment of VCS surveys has been carried out in Lake Biwa, JAPAN in November 2009 for a feasibility study. Prestack depth migration is applied to the 3D VCS data to obtain a high quality 3D depth volume. Based on the results from the feasibility study, we have developed two autonomous recording VCS systems. After we carried out a trial experiment in the actual ocean at a water depth of about 400m and we carried out the second VCS survey at Iheya Knoll with a deep-towed source. In this survey, we could establish the procedures for the deployment/recovery of the system and could examine the locations and the fluctuations of the vertical cables at a water depth of around 1000m. The acquired VCS data clearly shows the reflections from the sub-seafloor. Through the experiment, we could confirm that our VCS system works well even in the severe circumstances around the locations of seafloor hydrothermal deposits. We have carried out two field surveys in 2011. One is a 3D survey with a boomer for a high-resolution surface source and the other one for an actual field survey in the Izena Cauldron an active hydrothermal area in the Okinawa Trough. Through these surveys, we have confirmed that the

  16. Horse-like walking, trotting, and galloping derived from kinematic Motion Primitives (kMPs) and their application to walk/trot transitions in a compliant quadruped robot.

    Moro, Federico L; Spröwitz, Alexander; Tuleu, Alexandre; Vespignani, Massimo; Tsagarakis, Nikos G; Ijspeert, Auke J; Caldwell, Darwin G

    2013-06-01

    This manuscript proposes a method to directly transfer the features of horse walking, trotting, and galloping to a quadruped robot, with the aim of creating a much more natural (horse-like) locomotion profile. A principal component analysis on horse joint trajectories shows that walk, trot, and gallop can be described by a set of four kinematic Motion Primitives (kMPs). These kMPs are used to generate valid, stable gaits that are tested on a compliant quadruped robot. Tests on the effects of gait frequency scaling as follows: results indicate a speed optimal walking frequency around 3.4 Hz, and an optimal trotting frequency around 4 Hz. Following, a criterion to synthesize gait transitions is proposed, and the walk/trot transitions are successfully tested on the robot. The performance of the robot when the transitions are scaled in frequency is evaluated by means of roll and pitch angle phase plots. PMID:23463501

  17. Development of superconducting ship propulsion system

    When we plan displacement-type monohull high speed vessels, it is difficult to get the hull form with the wave-making resistance minimum, because the stern shape is restricted by arrangement of propulsive machines and shafts. A small-sized and light-weight propulsive machines will reduce the limit to full form design. Superconducting technology will have capability of realizing the small-sized and light-weight propulsion motor. The superconducting electric propulsion system which is composed of superconducting propulsion motors and generators, seems to be an ideal propulsion system for future vehicles. We have constructed a 480 kW superconducting DC homopolar laboratory test motor for developing this propulsion system. The characteristic of this motor is that it has a superconducting field winding and a segmented armature drum. The superconducting field winding which operates in the persistent current mode, is cooled by a condensation heat exchanger and helium refigerating system built into the cryostat of the superconducting field winding. The operating parameters of this motor agreed well with the design parameters. Using the design concepts of this motor, we have conceptually designed a 150,000-200,000 PS superconducting electric propulsive system for a displacement-type monohull high speed ship. (author)

  18. Development of oral cavity inspecting system

    Zhang, Hongxia; Wu, Di; Jia, Dagong; Zhang, Yimo

    2009-11-01

    An oral cavity inspecting system is designed and developed to inspect the detail of teeth. The inspecting system is composed of microscopic imaging part, illuminating part, image capture and processing, display part. The two groups of cemented lenses were optimized to minimize the optical aberration and the collimated beam light is gotten between the two lenses. A relay lens is adopted to allow the probe to access the oral cavity depth. The illumination optic fiber is used and the brightness and color temperature can be adjustable. The illumination fiber end surface is oblique cut and the optimum angle is 37°. The image of teeth is imaged on CMOS and captured into computer. The illumination intensity and uniformity were tested and the proper parameter is set. Foucault chart was observed and the system resolution is higher than 100lp/mm. The oral inspecting system is used to test standard tooth model and patho-teeth model. The tooth image is clear and the details can be observed. The experimental results show that the system could meet dental medical application requirements.

  19. System Analysis in Developing an Effective Government Internal Audit System

    Maliki Heru Santosa; Mohamad Syamsul Maarif; Eriyatno Eriyatno; Trias Andati

    2016-01-01

    Units of Government Internal Audit (GIA) play a significant role in developing a system of good governance. They contribute to the improvement of public services delivery and the welfare of society. But some current governance issues in Indonesia, such as corruption, accountability and performance problems, raise questions concerning the effectiveness of Indonesia’s GIA units. The complexity of these issues requires cybernetic study to find holistic and effective solutions. The objective of t...

  20. Tsunami Affected Farmland Extraction Using Morphological Profiles (MPs) Method by Satellite Images Including SAR and Visible Near-Infrared Band Data

    Yamada, Y.

    2015-04-01

    The agricultural fields along the coast were submerged under the sea water after the 2011 off the Pacific Coast of Tohoku Japan Tsunami. The conventional method of detecting Tsunami reached area by SAR satellite data is to compare the data obtained between previous to and after the Tsunami. However such kind of SAR data should be prepared prior to the natural disaster, but in many disaster cases, people have often encountered difficulties in finding such kind of data observed in advance in some regions. Therefore it is desirable to find a way to detect the flood suffering farmlands caused by a Tsunami, using only data observed after the disaster event. The morphological profiles (MPs) method are tested using ALOS/PALSAR and AVNIR-2 data. This MPs method is proposed as the tool for extracting information about the size, shape and the orientation of structures in single-band remote sensing images and has been improved to establish the extended morphological profiles(EMP) dealing with full-spectral information in the multi-/hyper-spectral data (Benediktsson, J.A. et al.,2003,2005). The author's work is intended to apply this MPs method to combined single polarization SAR data and visual and near-infrared bands data. The results approximately coincide with the farmland regions actually reached by the Tsunami. This MPs method requires only data once obtained soon after a disaster, light computer resources and very short turnaround time. It should be suitable for the detection of Tsunami reached areas or tidal wave reached areas, caused by a Typhoon for example, using satellite data only once obtained after a disaster.

  1. Lunar Surface Systems Supportability Technology Development Roadmap

    Oeftering, Richard C.; Struk, Peter M.; Green, Jennifer L.; Chau, Savio N.; Curell, Philip C.; Dempsey, Cathy A.; Patterson, Linda P.; Robbins, William; Steele, Michael A.; DAnnunzio, Anthony; Meseroll, Robert; Quiter, John; Shannon, Russell; Easton, John W.; Madaras, Eric I.; BrownTaminger, Karen M.; Tabera, John T.; Tellado, Joseph; Williams, Marth K.; Zeitlin, Nancy P.

    2011-01-01

    The Lunar Surface Systems Supportability Technology Development Roadmap is a guide for developing the technologies needed to enable the supportable, sustainable, and affordable exploration of the Moon and other destinations beyond Earth. Supportability is defined in terms of space maintenance, repair, and related logistics. This report considers the supportability lessons learned from NASA and the Department of Defense. Lunar Outpost supportability needs are summarized, and a supportability technology strategy is established to make the transition from high logistics dependence to logistics independence. This strategy will enable flight crews to act effectively to respond to problems and exploit opportunities in an environment of extreme resource scarcity and isolation. The supportability roadmap defines the general technology selection criteria. Technologies are organized into three categories: diagnostics, test, and verification; maintenance and repair; and scavenge and recycle. Furthermore, "embedded technologies" and "process technologies" are used to designate distinct technology types with different development cycles. The roadmap examines the current technology readiness level and lays out a four-phase incremental development schedule with selection decision gates. The supportability technology roadmap is intended to develop technologies with the widest possible capability and utility while minimizing the impact on crew time and training and remaining within the time and cost constraints of the program.

  2. EU developments of the ITER ECRH system

    The EU will be providing the largest contribution to the ITER electron cyclotron (EC) heating and current drive (H and CD) system (20 MW, CW at 170 GHz). The contribution includes one third of the H and CD gyrotrons, their associated power supplies and four upper port launcher antennas. In all areas of participation, the EU EC partnership (coordinated by the European Fusion Development Agreement) aims toward advancing the technology, while staying within a specified cost envelope. This is portrayed in the co-axial gyrotron development that offers the potential to double the output power per source (2.0 MW), increasing the delivered power for a fixed number of auxiliary systems. The EU partnerships also attempt to increase performance for the entire EC system, in particular the launching antennas. The proposed front steering launcher design offers greater control of MHD activity than the previous remote steering design and opens up the possibility of an enhanced performance UL. The EC physics requirements are repartitioned between the upper and equatorial launchers for a synergetic balance, which increases the EC physics capabilities while relaxing some of the engineering requirements

  3. Nematode model systems in evolution and development.

    Sommer, Ralf J; Bumbarger, Daniel J

    2012-01-01

    The free-living nematode Caenorhabditis elegans is one of the most important model organisms in all areas of modern biology. Using the knowledge about C. elegans as a baseline, nematodes are now intensively studied in evolution and development. Evolutionary developmental biology or for short, 'evo-devo' has been developed as a new research discipline during the last two decades to investigate how changes in developmental processes and mechanisms result in the modification of morphological structures and phenotypic novelty. In this article, we review the concepts that make nematode evo-devo a successful approach to evolutionary biology. We introduce selected model systems for nematode evo-devo and provide a detailed discussion of four selected case studies. The most striking finding of nematode evo-devo is the magnitude of developmental variation in the context of a conserved body plan. Detailed investigation of early embryogenesis, gonad formation, vulva development, and sex determination revealed that molecular mechanisms evolve rapidly, often in the context of a conserved body plan. These studies highlight the importance of developmental systems drift and neutrality in evolution. PMID:23801489

  4. Development of the plutonium oxide vitrification system

    Repository disposal of plutonium in a suitable, immobilized form is being considered as one option for the disposition of surplus weapons-usable plutonium. Accelerated development efforts were completed in 1997 on two potential immobilization forms to facilitate downselection to one form for continued development. The two forms studied were a crystalline ceramic based on Synroc technology and a lanthanide borosilicate (LaBS) glass. As part of the glass development program, melter design activities and component testing were completed to demonstrate the feasibility of using glass as an immobilization medium. A prototypical melter was designed and built in 1997. The melter vessel and drain tube were constructed of a Pt/Rh alloy. Separate induction systems were used to heat the vessel and drain tube. A Pt/Rh stirrer was incorporated into the design to facilitate homogenization of the melt. Integrated powder feeding and off-gas systems completed the overall design. Concurrent with the design efforts, testing was conducted using a plutonium surrogate LaBS composition in an existing (near-scale) melter to demonstrate the feasibility of processing the LaBS glass on a production scale. Additionally, the drain tube configuration was successfully tested using a plutonium surrogate LaBS glass

  5. Development of decommissioning system engineering technology

    In the decommissioning planning stage, it is important to select the optimized decommissioning process considering the cost and safety. Especially the selection of the optimized decommissioning process is necessary because it affects to improve worker's safety and decommissioning work efficiency. The decommissioning process evaluation technology can provide the optimized decommissioning process as constructing various decommissioning scenarios and it can help to prevent the potential accidents as delivering the exact work procedures to workers and to help workers to perform decommissioning work skillfully. It's necessary to measure the radioactive contamination in the highly contaminated facilities such as hot-cells or glove-boxes to be decommissioned for decommissioning planning. These facilities are very high radiation level, so it is difficult to approach. In this case the detector system is preferable to separate the sensor and electronics, which have to locate in the facility outside to avoid the electric noise and worker's radiation exposure. In this project, we developed the remote detection system for radiation measurement and signal transmission in the high radiation area. In order to minimize worker's exposure when decommissioning highly activated nuclear facilities, it is necessary to develop the remote handling tool to perform the dismantling work remotely. Especially, since cutting, measuring, and decontamination works should be performed remotely in the highly activated area, the remote handling tool for conducting these works should be developed. Therefore, the multi-purpose dismantling machine that can measuring dose, facility cutting, and remote handling for maintenance and decommissioning of highly activated facility should be needed

  6. Advanced systems: Status and development prospects

    World reserves of coal, uranium, thorium and thermonuclear fuel (deuterium and lithium) are sufficient to provide mankind with energy for many centuries. The rate of increase in demand is unlikely to be a limiting factor, and it would seem that any ''limits to growth'' will be dictated by other, in particular ecological, factors. In the last two decades, world power production has developed a structure in which a predominant place is occupied by oil and gas; this will have to change as a result of the marked depletion of oil resources and the enhanced role played in the fuel balance by power from coal and nuclear fission, on which, it would seem, the long-term growth of world energy production will be based. The contribution of nuclear fission power towards meeting world energy needs will depend on a number of factors, the most important of which from a long-term point of view is the time and rate of introduction of advanced nuclear power systems and fuel cycles with high nuclear fuel surpluses (breeding ratios). The results of almost 30 years of development of nuclear power with thermal-neutron reactors may serve as a basis for the analysis, evaluation and forecasting of the development of advanced systems. (author)

  7. Effect of MPS concentration on ripening kinetics and structural properties of CdS quantum dots in self-assembled thin films

    Koc, Kenan

    2015-12-01

    The colloidal CdS quantum dots (QDs) were synthesized with various molar ratios of 3-mercaptopropyltrimethoxysilane (MPS) molecules. The results show that the smaller size of CdS QDs was obtained at the higher molar concentration of MPS. Sol-gel spin coating method was used for deposition of the colloidal nanoparticles on a glass substrate. One pot production method was used to obtain self-assembled thin films of CdS QDs in SiO2 network and the grow kinetics of QDs were investigated. The samples were heat treated at various temperatures to observe the growth of the QDs. The sizes of the QDs were obtained in the range of 2-5 nm depending on the capping agent concentration and heat-treatment temperature. The activation energies for the Ostwald ripening process were found as 38.7, 56.4, 93,1 and 98.6 kJ/mol for the samples containing molar ratio of MPS:Cd = 0.25, 0.50, 1.00 and 2.00 respectively.

  8. Renal Function and NODM in De Novo Renal Transplant Recipients Treated with Standard and Reduced Levels of Tacrolimus in Combination with EC-MPS

    Laurence Chan

    2012-01-01

    Full Text Available Information is lacking concerning concomitant administration of enteric-coated mycophenolate sodium with tacrolimus (EC-MPS+Tac in renal transplant recipients (RTxR. In this 6-month, prospective, open-label, multicenter study, de novo RTxR were randomized (1 : 1 to low-dose (LD or standard-dose (SD Tac with basiliximab, EC-MPS 720 mg bid, and steroids. Primary objective was to compare renal function at 6-month posttransplantation. Secondary objectives were to compare the incidences of biopsy-proven acute rejection (BPAR, graft loss and death, and new-onset diabetes mellitus (NODM. 292 patients (LD n=151, SD n=141 were included. Mean Tac levels were at the low end of the target range in standard-exposure patients (SD, n=141 and exceeded target range in low-exposure patients (LD = 151 throughout the study. There was no significant difference in mean glomerular filtration rate (GFR between treatments (ITT-population: 63.6 versus 61.0 mL/min. Incidence of BPAR was similar (10.6% versus 9.9%. NODM was significantly less frequent in LD Tac (17% versus 31%; P=0.02; other adverse effects (AEs were comparable. EC-MPS+Tac (LD/SD was efficacious and well tolerated with well-preserved renal function. No renal function benefits were demonstrated, possibly related to poor adherence to reduced Tac exposure.

  9. Immunogenic properties and mycoplasmal pneumonia of swine (MPS) lung lesions in Large White pigs selected for higher peripheral blood immune capacity.

    Borjigin, Liushiqi; Shimazu, Tomoyuki; Katayama, Yuki; Li, Meihua; Satoh, Takumi; Watanabe, Kouichi; Kitazawa, Haruki; Roh, Sang-Gun; Aso, Hisashi; Katoh, Kazuo; Uchida, Takafumi; Suda, Yoshihito; Sakuma, Akiko; Nakajo, Mituru; Suzuki, Keiichi

    2016-05-01

    Immunogenic properties and mycoplasmal pneumonia of swine (MPS) lung lesions were compared between the immunity-selected Large White line and the non-selected Large White line. The selected Large White line showed a higher level of pulmonary MPS lesions compared with the non-selected Large White line. Subsequent to vaccination, the percentage of natural killer cells and T cells (CD3(+) CD4(+) CD8(-) and CD3(+) CD4(-) CD8(+) T cells) were significantly increased in the non-selected line but remained unchanged in the immunity-selected Large White line. Secretion of Mycoplasma hyopneumoniae vaccine-specific immunoblogulin G and phagocyte activity in peripheral blood were significantly higher in the immunity-selected Large White line than in the non-selected line. Expression of interleukin (IL)-4 and IL-6 messenger RNA in hilar lymph nodes was significantly lower in the immunity-selected Large White line than in the non-selected line. However, expression of IL-10 in all immune tissues was significantly higher in the immunity-selected Large White line. These results suggest that the selection for high immunity was not effective in increasing resistance to MPS lung lesions. PMID:26388420

  10. Renal Function and NODM in De Novo Renal Transplant Recipients Treated with Standard and Reduced Levels of Tacrolimus in Combination with EC-MPS

    Chan, Laurence; Andres, Amado; Bunnapradist, Suphamai; Gugliuzza, Kristene; Parasuraman, Ravi; Peddi, V. Ram; Cassuto, Elisabeth; Hart, Marquis

    2012-01-01

    Information is lacking concerning concomitant administration of enteric-coated mycophenolate sodium with tacrolimus (EC-MPS+Tac) in renal transplant recipients (RTxR). In this 6-month, prospective, open-label, multicenter study, de novo RTxR were randomized (1 : 1) to low-dose (LD) or standard-dose (SD) Tac with basiliximab, EC-MPS 720 mg bid, and steroids. Primary objective was to compare renal function at 6-month posttransplantation. Secondary objectives were to compare the incidences of biopsy-proven acute rejection (BPAR), graft loss and death, and new-onset diabetes mellitus (NODM). 292 patients (LD n = 151, SD n = 141) were included. Mean Tac levels were at the low end of the target range in standard-exposure patients (SD, n = 141) and exceeded target range in low-exposure patients (LD = 151) throughout the study. There was no significant difference in mean glomerular filtration rate (GFR) between treatments (ITT-population: 63.6 versus 61.0 mL/min). Incidence of BPAR was similar (10.6% versus 9.9%). NODM was significantly less frequent in LD Tac (17% versus 31%; P = 0.02); other adverse effects (AEs) were comparable. EC-MPS+Tac (LD/SD) was efficacious and well tolerated with well-preserved renal function. No renal function benefits were demonstrated, possibly related to poor adherence to reduced Tac exposure. PMID:23227307

  11. LC Filter for High Accuracy and Stability Digital MPS at PLS

    Kim Sung Chul; Man Ha Ki; Yun Huang Jung

    2005-01-01

    High accuracy and stability digital power supply for magnet is developed at PLS. This power supply has three sections. The first section is digital controller including DSP&FPGA and precision ADC, the second consists of IGBT driver and four quad IGBT switch, and the third is LC output section. AC input voltage of power supply is 3-phase 21V, output current is 0 ~ 150 A dc. Switching frequency of IGBT is 25 kHz. The output current of power supply has very high accuracy of 100 mA step resolution at full range and the stability of ± 1.5 ppm for short term and ± 5 ppm for long term. This paper describes characteristics of filter and output current performance improvement after LC output filter at four quad digital power supplies.

  12. Simulation as a decisison support tool in maintenance float systems

    Pereira, Guilherme; Peito, Francisco; Leitão, Armando; Dias, Luís M. S.

    2011-01-01

    This paper is concerned with the use of simulation as a decision support tool in maintenance systems, specifically in MPS (Maintenance Float Systems). For this purpose and due to its high complexity, in this paper the authors explore and present a possible way to construct a MPS model using Arena® simulation language, where some of the most common performance measures are identified, calculated and analysed.

  13. New developments of the GANIL control system

    Since its first ion beam, the GANIL accelerator has been driven by a Control System built around a minicomputer MITRA 125 and a distributed intelligence consisting of programmable Controllers and INTEL 8080 equipped autonomous CAMAC Controllers. After a brief description of the GANIL Control System, this paper will lay emphasis on the major improvements undertaken along four main directions: a) Upgrading the Control Computer. b) Introducing more powerful local intelligence. A microprocessorized autonomous CAMAC Controller called ''DIVA 68C'' using the 68000 microprocessor embedded in a VME card has been developed. Also, the 68000 will be used in a general purpose CAMAC module, the first application of which is to replace the existing data link modules. (c) Making human-machine dialog smarter with use of color graphic terminals. d) Meeting the requirements of the coming second injector. In this purpose a fully equipped auxiliary console is being installed near the main console for operation by summer 1985

  14. Developing Information System on Lunar Crescent Observations

    T. Hidayat

    2010-03-01

    Full Text Available We present a progress report on the development of information system of lunar crescent astronomical observations which will be largely accessible for public domain. This consists of calculations of the Moon’s ephemeris as well as systematic real-time lunar crescent observations. A well suited small telescope, equipped with a simple digital detector, is connected to a server to provide information on lunar crescent observations. The system has been used and worked well. The only constraint is poor weather condition. Network of small telescopes, installed at various locations in Indonesia, are currently planned to provide plethora of data. In the long term, this will be used to help to determine the astronomical visibility criteria of lunar crescent for Islamic calendar.

  15. Development of energy and transport systems

    Economic development and the advancement of technology is presented as a process of substituting old forms of satisfying human needs by new ones or, more precisely, as a sequence of such substitutions. The examples, reconstructed from historical records, describe the quantitative, technological changes in energy and transport systems. The analysis of historical replacement of old by new technologies has shown that most of these processes can be described by simple rules that are captured in the logistic substitution model, and that technological substitution, expressed in terms of market shares, follows characteristic S-shaped curves. To illustrate the properties of the approach examples are given of how new energy forms replaced their predecessors. To further explore the method similar substitution processes in transport systems are described. 21 refs, 23 figs, 1 tab

  16. NANOTECHNOLOGY IN DEVELOPMENT OF DRUG DELIVERY SYSTEM

    Vidyavathi Maravajhala et al.

    2012-01-01

    Full Text Available Nanotechnology is science of matter and material that deal with particle size in nanometers. Nanotechnology has received a lot of attention with never-seen-before enthusiasm because of its future potential. It has provided fine lined diagnosis and focus treatment of disease at molecular level. This technology offers the advantage of protecting drugs from degradation; reduce the number of doses required. In this review, a discussion was carried out on different techniques for the preparation of nanodrug delivery systems like nanoparticles, solid lipid nanoparticles, nanocrystals, nanosuspensions, nanoemulsions. The concept of nanotechnology is widely expanded and applied to many drugs to the present. The ultimate application goal of nano drug delivery system is to develop clinically useful formulation for treating diseases in patients.

  17. Development of the Open Items Tracking System

    The West Valley Demonstration Project, located on the site of the only commercial nuclear fuel reprocessing facility to have operated in USA, has the directed objectives of solidifying the high-level radioactive waste into a durable, solid form for shipment; decontaminating and decommissioning the tanks and facilities; and disposing of the resulting low-level and transuranic wastes. Since an escalating trend of open work items was noticed in the Fall of 1988, and there was no control mechanism for tracking and closing the open items, a Work Control System was developed for this purpose. It is self-contained system on a mainframe ARTEMIS 9000, which tracks, monitors, and closes out external commitments in a timely manner. Audits, surveillances, site appraisals, preventive maintenance, instrument calibration recall, and scheduling are covered

  18. DEVELOPMENT AND MARKET OF ERP SYSTEMS

    DIANA-ELENA CODREANU

    2012-11-01

    Full Text Available The business environment’s changes occurring more and more quickly and company activities’ becoming more and more complex require permanent, fast adjustments which often test human factors’ abilities for efforts and analyses. The creation and development of ERP-type systems have been and are still believed to be the solutions of such challenges ensuring certain support to process large amounts of data and information needed in companies’ decision-making processes. An ERP system helps the integration of a company’s set of information into a single platform due to the way in which it succeeds in combining business management techniques and practices with the new information technology, providing the transparency of data and the access to the necessary information.

  19. Development of the power system for accelerator

    The 100-MeV proton linac needs 4 modulators whose specification is as follows, -115kV, 55A, and 9%. The development of the modulators were successfully finished and installed at Gyeongju site of KAERI. One of them was used and successfully tested in the 20-MeV linac operation at Daejeon site. The klystron is used to supply the high power RF into the accelerating structure. There are 2 klystrons for 20-MeV part of the linac and 7 klystrons from 20-MeV to 100-MeV region. The maximum voltage is ?105kV, the peak power is 1.6 MW, and the duty is 9%. All of the 7 klystrons have been fabricated, tested and installed. The high power RF system includes circulators, dummy lodes, RF windows, and wave-guides. The development of the high power RF components was finished and they were installed at the Gyeongju site. The 11 sets of RCCS (resonant control cooling system) will be used to control the cooling water temperature inside the accelerating structure. The temperature range of the cooling water covers between 21 .deg. C and 33 .deg. C with the 0.1 .deg. C control. All RCCSs were installed in the klystron gallery. Purposes of the 20-MeV linac operation at Daejeon site of KAERI (2007∼2011) are to supply proton beams to user, to porve the accelerator performance, to test the developed components including LLRF, diagnostics, and control system, and to measure the proton beam properties. During the period, the total number of samples reaches to 1,603 and the average machine availability becomes 96.2%. The 20-MeV linac was disassembled, moved and installed at Gyeongju site after finishing the test operation

  20. Development of the High Energy Linac Systems

    The main purpose of this project is studying the extension plan of the proton engineering frontier project (PEFP) 100-MeV Linac. It includes three categories. One is studying operation plan of the PEFP linac and its extended accelerators, and developing a distribution system of 100-MeV proton beams with a laser striping. Other is designing superconducting RF (SRF) modules and fabricating and testing a copper cavity model. The other is designing a rapid cycling synchrotron (RCS). The operation scheme of the PEFP linac is related to the optimization in the operation of the 100-MeV linac, 200-MeV SRF, and RCS. We studied several operational method to increase the validity of the accelerators. The beam distribution system has two roles. One is supplying proton beams of 100 MeV to the user group. The laser stripping of the negative hydrogen atoms is used in this case. The other beams are directed to the next high energy accelerators. This study contributes to increase the availability of the proton beams. The SRF is one of candidates to extend the PEFP linac system. Since the accelerating gradient of the SRF is much higher than the normal conducting accelerator, a lot of institutes over the world are developing the SRF structure. Main purposes are designing an SRF module, fabricating and testing an copper model which has similar material properties as Nb of the usual SRF cavity material. The RCS is a synchrotron whose injector is the PEFP 100-MeV linac. Main purposes are determining the lattice structure, studying the fast and slow extraction system, simulating beam behavior in the designed synchrotron. The RCS will be used as the spallation neutron source and tools in the basic and applied science including medical application

  1. EU Developments of the ITER ECRH System

    The electron cyclotron (EC) heating and current drive (H (and) CD) system of ITER will deliver 20 MW/CW in the plasma at 170 GHz for H (and) CD in addition to 2.5 MW/3 s at 120 GHz for plasma start-up. The EC system is composed of power supplies (PS), up to 24 H (and) CD gyrotrons (1 to 2 MW tubes), 3 start-up gyrotrons (1 MW tubes), 24 transmission lines and two sets of launching antennas: equatorial (EL) and upper (UL) launchers. Under the present ITER procurement package the EU is responsible for one third of the H (and) CD 170 GHz gyrotrons, all PSs associated with the H (and) CD system, and the whole set (4) of upper launchers. In all areas of participation, the EU EC partnership (coordinated by the European Fusion Development Association - EFDA) aims toward advancing the technology of each of these subsystems. For example, procurement of Pulse Step Modulator (PSM) HVPS is under consideration, which might have equivalent costs to the present ITER design (thyristor HVPS and HV series switch), but with an increased flexibility in operation and variation in the EC power waveform. The EU is at the forefront in gyrotron research and is developing a 2 MW CW 170 GHz coaxial cavity gyrotron offering an increase in output power while maintaining moderate power densities in the gyrotron cavity and collector. THALESR in collaboration with its EFDA partners (FZK, CRPP, TEKES) is manufacturing a series of prototype tubes in three phases of typically 1 s, 100 s and then CW pulse capacity (∼ 2010). A 2 MW, CW gyrotron test facility is being built at CRPP that will be used to develop the 2 MW coaxial tube, in addition to testing various components required by the EC system. EFDA has undertaken a parallel development of two launcher options: front (FS) and remote (RS) steering, with the aim of providing an optimum launcher for ITER weighing EC physics aspects and operation reliability. The FS launcher (ITER reference design) offers a significant enhancement in physics

  2. Recent developments in modeling groundwater systems

    Narasimhan, T.N.; Witherspoon, P.A.

    1977-05-20

    This paper reviews the developments in the mathematical modeling of groundwater systems over the past decde. The first part of the paper is devoted to a description of the physics of the different types of problems that are of interest in hydrogeology and a statement of the related initial-boundary-value problems. The various numerical techniques that have been employed to solve the governing equations are discussed in the second part. In the third section a few typical case histories are presented to illustrate the trend of progress that has occurred in the application of mathematical modeling to actual field problems.

  3. Development techniques of computerized maintenance Management system

    Oh, Yon Woo; Kim, S.D.; Soong, W.S.; Kim, G.H.; Oh, W.H.; Kim, Y.G

    2000-05-01

    Normal operation of the facility is one of the key factors in the accomplishments of research goals. As confirmed by a case study of the influence of the facility operation condition on the research results, emphasis should be put on the facility preserve management. Facilities should be maintained in solid operational condition and their malfunctions should be repaired as soon as possible. The purpose of this project is to make propositions on the development of the facility preserve management system which is to maximize the efficiency of the budget execution, manpower organization and maintenance planning, and is to minimize the duration of the operational pause due to malfunctions with the least disbursement.

  4. Mobile Systems Development: An Empirical Study

    Hosbond, J. H.

    As part of an ongoing study on mobile systems development (MSD), this paper presents preliminary findings of research-in-progress. The debate on mobility in research has so far been dominated by mobile HCI, technological innovations, and socio-technical issues related to new and emerging mobile...... present preliminary findings from an on-going multiple case study that indicates and support a five-layered segmentation of the mobile industry, and (2) I propose four modes of operation reflecting the diversified nature of MSD....

  5. Development of a smart multilead thermocouple system

    Smart sensors are sensors that have independent self-diagnosis, communication, and computation abilities. Such features are highly desirable in the nuclear and other industries for economical and safety concerns. These features have become possible since fast, miniature, and inexpensive microprocessors became widely available. A smart temperature measurement system (STMS) using a multilead thermocouple (MTC) has been developed and tested at the nuclear engineering department, the University of Tennessee at Knoxville. The basic concept of the design is that an MTC, which consists of several wires joined at a single junction, has the potential to provide redundant temperature measurements with a single standard-size sensor

  6. Wireless Power Transfer system : Development and Implementation

    Khayrudinov, Vladislav

    2015-01-01

    The goal of the project was to develop a Wireless Power Transfer (WPT) System and implement it in innovative flooring. The project was done at NextFloor Oy, a company based in Helsinki, Finland. At the moment, Wireless Power Transmission is in the forefront of electronics research, which is why this study started as an initial attempt to investigate WPT in order to keep up with the fast growing industry. The main steps of the project were to study the physics behind wireless electricity t...

  7. Development of a THz spectroscopic imaging system

    We have developed a real-time THz imaging system based on the two-dimensional (2D) electro-optic (EO) sampling technique. Employing the 2D EO-sampling technique, we can obtain THz images using a CCD camera at a video rate of up to 30 frames per second. A spatial resolution of 1.4 mm was achieved. This resolution was reasonably close to the theoretical limit determined by diffraction. We observed not only static objects but also moving ones. To acquire spectroscopic information, time-domain images were collected. By processing these images on a computer, we can obtain spectroscopic images. Spectroscopy for silicon wafers was demonstrated

  8. Recent development of plasma optical systems (invited)

    Goncharov, A. A.

    2016-02-01

    The article devotes a brief description of the recent development and current status of an ongoing research of plasma optical systems based on the fundamental plasma optical idea magnetic electron isolation, equipotentialization magnetic field lines, and the axi-symmetric cylindrical electrostatic plasma lens (PL) configuration. The experimental, theoretical, and simulation investigations have been carried out over recent years collaboratively between IP NASU (Kiev), LBNL (Berkeley, USA), and HCEI RAS (Tomsk). The crossed electric and magnetic fields inherent the PL configuration that provides the attractive method for establishing a stable plasma discharge at low pressure. Using PL configuration, several high reliability plasma devices were developed. These devices are attractive for many high-tech applications.

  9. Recent development of plasma optical systems (invited)

    Goncharov, A. A., E-mail: gonchar@iop.kiev.ua [Institute of Physics, National Academy of Science, Kiev 03028 (Ukraine)

    2016-02-15

    The article devotes a brief description of the recent development and current status of an ongoing research of plasma optical systems based on the fundamental plasma optical idea magnetic electron isolation, equipotentialization magnetic field lines, and the axi-symmetric cylindrical electrostatic plasma lens (PL) configuration. The experimental, theoretical, and simulation investigations have been carried out over recent years collaboratively between IP NASU (Kiev), LBNL (Berkeley, USA), and HCEI RAS (Tomsk). The crossed electric and magnetic fields inherent the PL configuration that provides the attractive method for establishing a stable plasma discharge at low pressure. Using PL configuration, several high reliability plasma devices were developed. These devices are attractive for many high-tech applications.

  10. Development of an automated ultrasonic testing system

    Shuxiang, Jiao; Wong, Brian Stephen

    2005-04-01

    Non-Destructive Testing is necessary in areas where defects in structures emerge over time due to wear and tear and structural integrity is necessary to maintain its usability. However, manual testing results in many limitations: high training cost, long training procedure, and worse, the inconsistent test results. A prime objective of this project is to develop an automatic Non-Destructive testing system for a shaft of the wheel axle of a railway carriage. Various methods, such as the neural network, pattern recognition methods and knowledge-based system are used for the artificial intelligence problem. In this paper, a statistical pattern recognition approach, Classification Tree is applied. Before feature selection, a thorough study on the ultrasonic signals produced was carried out. Based on the analysis of the ultrasonic signals, three signal processing methods were developed to enhance the ultrasonic signals: Cross-Correlation, Zero-Phase filter and Averaging. The target of this step is to reduce the noise and make the signal character more distinguishable. Four features: 1. The Auto Regressive Model Coefficients. 2. Standard Deviation. 3. Pearson Correlation 4. Dispersion Uniformity Degree are selected. And then a Classification Tree is created and applied to recognize the peak positions and amplitudes. Searching local maximum is carried out before feature computing. This procedure reduces much computation time in the real-time testing. Based on this algorithm, a software package called SOFRA was developed to recognize the peaks, calibrate automatically and test a simulated shaft automatically. The automatic calibration procedure and the automatic shaft testing procedure are developed.

  11. Progress in coating development for fusion systems

    Development of effective and reliable coatings is a key to the viability of most, if not all, fusion blanket systems. The specific purpose and requirements of the coatings vary widely, depending on the blanket concept. The efforts on coating development to date have focused primarily on electrically insulating coatings for the self-cooled lithium concepts with a vanadium alloy structure, and the tritium barrier coatings for the water-cooled, Pb-Li (WCLL) breeder concepts with ferritic steel structures. Although other coating materials are under consideration, most of the effort on the electrically insulating coatings has focused on CaO and AlN coatings on V-4Cr-4Ti alloy structure. Most of the effort on the tritium barrier coating development is focused on Al2O3 coatings formed on aluminized ferritic steels. This paper presents an overview of the status of coating development for the various fusion concepts with emphasis on the materials interaction and chemistry control issues associated with the formation, stability and performance of the coatings

  12. Development of a multispectral camera system

    Sugiura, Hiroaki; Kuno, Tetsuya; Watanabe, Norihiro; Matoba, Narihiro; Hayashi, Junichiro; Miyake, Yoichi

    2000-05-01

    A highly accurate multispectral camera and the application software have been developed as a practical system to capture digital images of the artworks stored in galleries and museums. Instead of recording color data in the conventional three RGB primary colors, the newly developed camera and the software carry out a pixel-wise estimation of spectral reflectance, the color data specific to the object, to enable the practical multispectral imaging. In order to realize the accurate multispectral imaging, the dynamic range of the camera is set to 14 bits or over and the output bits to 14 bits so as to allow capturing even when the difference in light quantity between the each channel is large. Further, a small-size rotary color filter was simultaneously developed to keep the camera to a practical size. We have developed software capable of selecting the optimum combination of color filters available in the market. Using this software, n types of color filter can be selected from m types of color filter giving a minimum Euclidean distance or minimum color difference in CIELAB color space between actual and estimated spectral reflectance as to 147 types of oil paint samples.

  13. Development of small, modular biomass power systems

    Turnbull, J.H. [Peninsula Energy Partners, Los Altos, CA (United States); Hulkkonen, S. [IVO/EPRI, Palo Alto, CA (United States); Dracker, R. [Bechtel Corp., San Francisco, CA (United States)

    1996-12-31

    This paper describes a collaborative effort between the Electric Power Research Institute, Bechtel Corporation and Imatran Voima Oy. The goal is commercialization of a biomass-fueled, modular (50 to 250 kW) heat and power technology for distributed applications. The technology to be selected will not present any major technical challenges, but first and foremost must be simple and reliable. Additional criteria include: acceptable capital cost, fuel flexibility, and the capability for meeting local environmental standards. As the capital cost of small units will be influenced by economies of fabrication, the economic viability of these systems depends upon the size of the domestic and international markets. Thus, evaluation of available conversion technologies was undertaken concurrently with a broad-based market assessment. The technology scan included all the commercial and pre-commercial biomass systems that could be located. Information was sorted into five categories: (1) gasifiers with either diesel or spark-ignited engines; (2) indirectly fired gas turbines; (3) directly fired gas turbines; (4) pyrolysis processes with diesel engines; or (5) conventional steam-cycles. The evaluation of the technologies was based on the above criteria, along with the recognition that the levelized cost of power from the system must be competitive with available diesel generation. The market for these systems within the contiguous 48 states is expected to be limited to situations involving forest ecosystem improvements and the reduction of forest fire hazards, and/or clean-up and remediation following natural disasters. Another North American market is remote villages in Canada and Alaska. By far the largest market is in developing nations where two billion people are without electricity for lighting, water pumping or refrigeration. Serving this latter market presents a major challenge, as each system will require establishment of a whole new local infrastructure.

  14. Development of NRU reflector wall inspection system

    In 2009 May, the National Research Universal (NRU) calandria leaked. During the next year, the calandria was inspected with six new Non-Destructive Evaluation (NDE) techniques to determine the extent of the corrosion, repaired, and finally the repair was inspected with four additional new NDE techniques before the reactor was returned to service. The calandria is surrounded by a light-water reflector vessel fabricated from the same material as the calandria vessel. Concerns that the same corrosion mechanism had damaged the reflector vessel led to the development of a system to inspect the full circumference of the reflector wall for corrosion damage. The inspection region could only be accessed through 64 mm diameter ports, was 10 m below the port, and had to be inspected from the corroded surface. The ultrasonic technique was designed to produce a closely spaced wall thickness (WT) grid over an area of approximately 5 m2 on the corroded surface using a very small probe holder. This paper describes the Reflector Wall Inspection (RWI) development project and the system that resulted. (author)

  15. Development of NRU reflector wall inspection system

    Lumsden, R.H.; Luloff, B.V.; Zahn, N.; Simpson, N., E-mail: lumsdenr@aecl.ca [Atomic Energy of Canada Limited, Chalk River, Ontario (Canada)

    2013-06-15

    In 2009 May, the National Research Universal (NRU) calandria leaked. During the next year, the calandria was inspected with six new Non-Destructive Evaluation (NDE) techniques to determine the extent of the corrosion, repaired, and finally the repair was inspected with four additional new NDE techniques before the reactor was returned to service. The calandria is surrounded by a light-water reflector vessel fabricated from the same material as the calandria vessel. Concerns that the same corrosion mechanism had damaged the reflector vessel led to the development of a system to inspect the full circumference of the reflector wall for corrosion damage. The inspection region could only be accessed through 64 mm diameter ports, was 10 m below the port, and had to be inspected from the corroded surface. The ultrasonic technique was designed to produce a closely spaced wall thickness (WT) grid over an area of approximately 5 m2 on the corroded surface using a very small probe holder. This paper describes the Reflector Wall Inspection (RWI) development project and the system that resulted. (author)

  16. Active Thermal Control System Development for Exploration

    Westheimer, David

    2007-01-01

    All space vehicles or habitats require thermal management to maintain a safe and operational environment for both crew and hardware. Active Thermal Control Systems (ATCS) perform the functions of acquiring heat from both crew and hardware within a vehicle, transporting that heat throughout the vehicle, and finally rejecting that energy into space. Almost all of the energy used in a space vehicle eventually turns into heat, which must be rejected in order to maintain an energy balance and temperature control of the vehicle. For crewed vehicles, Active Thermal Control Systems are pumped fluid loops that are made up of components designed to perform these functions. NASA has been actively developing technologies that will enable future missions or will provide significant improvements over the state of the art technologies. These technologies have are targeted for application on the Crew Exploration Vehicle (CEV), or Orion, and a Lunar Surface Access Module (LSAM). The technologies that have been selected and are currently under development include: fluids that enable single loop ATCS architectures, a gravity insensitive vapor compression cycle heat pump, a sublimator with reduced sensitivity to feedwater contamination, an evaporative heat sink that can operate in multiple ambient pressure environments, a compact spray evaporator, and lightweight radiators that take advantage of carbon composites and advanced optical coatings.

  17. Development for 972MHz LLRF system

    The large electric power (972MHz, 3MW, Pulse width: 600-700μsec, duty: 50Hz) RF is outputted to the ACS cave used by The J-PARC linear accelerator by the klystron. The klystron driver amplifier of the developed LLRF system serves as the output 40W, and a pulse reply is 25nsec. The high frequency phase control can carry out variable in resolution of 0.1 degree or less, and the phase stability of less than ±1 degree. As a protection feature of equipment, RF is intercepted by the electric power anomaly detection of a progressive wave and a reflected wave, electric discharge detection, and VSWR anomaly detection. About VSWR anomaly detection, FPGA is adopted as VSWR arithmetic processing and RF is intercepted in less than 1 microsec. It receives unusually [the electric power of a progressive wave and a reflected wave], and can intercept RF in 300nsec with a high-speed comparator. To electric discharge, a high-speed arc sensor can be developed by high sensitivity, and RF can be intercepted in about 1 microsec. As for the whole LLRF system, sequence control is performed by the PLC unit. This paper reports the design work, the manufacture and a power measurement. (author)

  18. Genotoxic sensitivity of the developing hematopoietic system.

    Udroiu, Ion; Sgura, Antonella

    2016-01-01

    Genotoxic sensitivity seems to vary during ontogenetic development. Animal studies have shown that the spontaneous mutation rate is higher during pregnancy and infancy than in adulthood. Human and animal studies have found higher levels of DNA damage and mutations induced by mutagens in fetuses/newborns than in adults. This greater susceptibility could be due to reduced DNA repair capacity. In fact, several studies indicated that some DNA repair pathways seem to be deficient during ontogenesis. This has been demonstrated also in murine hematopoietic stem cells. Genotoxicity in the hematopoietic system has been widely studied for several reasons: it is easy to assess, deals with populations cycling also in the adults and may be relevant for leukemogenesis. Reviewing the literature concerning the application of the micronucleus test (a validated assay to assess genotoxicity) in fetus/newborns and adults, we found that the former show almost always higher values than the latter, both in animals treated with genotoxic substances and in those untreated. Therefore, we draw the conclusion that the genotoxic sensitivity of the hematopoietic system is more pronounced during fetal life and decreases during ontogenic development. PMID:27036061

  19. Development of CANDU Spent Fuel Sipping System

    As the tendency is toward radioactivity zero-leakage on the reactor core for the safe operation of nuclear power plants, the importance of detecting radioactivity leaking from fuel assemblies irradiated in the core is being on the rise. Nuclear fuel, even though it is designed and fabricated in terms of excellent thermal performance and mechanical integrity, can be damaged under unexpected circumstances. An excessive hydriding on fuel rods and pellet-to-clad interaction., etc. can result in failed fuel rod. It is, thus, considered that a inspection process is prerequisite procedure to identify causes of such failed fuel rods for the safe operation of nuclear power plants. If a fuel rod failure occurs during the operation of a nuclear power plant, the coolant water becomes contaminated by leaked fission products, and the power level of the plant has to be lowered or the operation to be stopped. In addition, the spent fuel that have been stored in a spent fuel storage pool for a long time is now transferring to a dry storage. To maximize the integrity of the dry storage, all the fuels transferring to a dry storage should be examined their integrities exactly and efficiently. Therefore, the ultimate purpose of this study is to develop a system capable of judging whether the long-term stored fuel in spent fuel storage pool is failed or not. In this study, a spent fuel sipping system with wet leakage detection technology is developed to make it possible

  20. Development of flat panel digital radiography system

    We developed the Digital Radiography System CXDI-11 which digitizes the X-ray image in high quality by using a self-developed flat panel detector. The CXDI-11 has a large image area of 43 cm x 43 cm (17'' x 17''), and it can display the image on the pre-view monitor after only 3 seconds of exposure. In this report, we present the principle and the physical characteristics of the CXDI-11. The X-ray detector installed in the CXDI-11 is a combination of a rare-earth scintillator and an amorphous silicon flat panel detector (LANMIT). The X-ray is converted to the visible fluorescent light at the scintillator and the light is detected by the LANMIT. The image-processed data is transferred to the DICOM3.0 conformed devices such as the diagnosis work station, the archiver and the laser imager through the network. We also show some measurement results of the dynamic range, the pre-sampling Modulation Transfer Function and the tube voltage dependent sensitivity. The CXDI-11 is superior in real time operation and image quality, thus it is the digital radiography system of the next generation. (author)

  1. System Analysis in Developing an Effective Government Internal Audit System

    Maliki Heru Santosa

    2016-01-01

    Full Text Available Units of Government Internal Audit (GIA play a significant role in developing a system of good governance. They contribute to the improvement of public services delivery and the welfare of society. But some current governance issues in Indonesia, such as corruption, accountability and performance problems, raise questions concerning the effectiveness of Indonesia’s GIA units. The complexity of these issues requires cybernetic study to find holistic and effective solutions. The objective of this study is to examine the effectiveness of government internal audit systems in order to enhance the professionalism of government internal auditors and the maturity of the management processes that they audit.  This research was based on qualitative approaches with systems methodology. The instruments used during the research were regulatory analysis, survey, and in-depth interviews. The survey involved 205 Chief Audit Executives (CAE of Government Internal Supervisory Apparatus (GISA in national government and regional governments, and was conducted on-line or on paper. The survey was complemented by in-depth interview with 24 (twenty four senior stakeholders representing practitioners (the CAE of GISA units, internal users (governors, mayors, heads of regional planning agencies, external users (Indonesia’s Supreme Audit Board, SAB, regulators, and associations of professional internal auditors, both private sector (IIA and public sector (AAIPI. The research found that the effort of enhancing the role of the GIA units should be seen holistically. The improvement of the role of GIA units related to the stakeholders, including management line of the organization, the SAB, professional associations, regulators, and law enforcement officials as well as other factors. The arrangement of the internal audit system could allow the government auditors to improve their professionalism and help line management to mature their management processes. The emerging

  2. Web-based Core Design System Development

    The selection of a loading pattern is one of core design processes in the operation of a nuclear power plant. A potential new loading pattern is identified by selecting fuels that to not exceed the major limiting factors of the design and that satisfy the core design conditions for employing fuel data from the existing loading pattern of the current operating cycle. The selection of a loading pattern is also related to the cycle plan of an operating nuclear power plant and must meet safety and economic requirements. In selecting an appropriate loading pattern, all aspects, such as input creation, code runs and result processes are processed as text forms manually by a designer, all of which may be subject to human error, such as syntax or running errors. Time-consuming results analysis and decision-making processes are the most significant inefficiencies to avoid. A web-based nuclear plant core design system was developed here to remedy the shortcomings of an existing core design system. The proposed system adopts the general methodology of OPR1000 (Korea Standard Nuclear Power Plants) and Westinghouse-type plants. Additionally, it offers a GUI (Graphic User Interface)-based core design environment with a user-friendly interface for operators. It reduces human errors related to design model creation, computation, final reload core model selection, final output confirmation, and result data validation and verification. Most significantly, it reduces the core design time by more than 75% compared to its predecessor

  3. Developments of a Targeted Ensemble Prediction System

    Hersbach, H.; Mureau, R.; Opsteegh, J. D.; Barkmeijer, J.

    2003-04-01

    Based on results presented in a previous paper, an Ensemble Prediction System, especially designed for the short-range to early-medium range for the European domain (TEPS), was further developed. Between 1 January 1999 and 27 February 2000 this system was run for two cases per week. Results were compared to the ensemble prediction system (EPS) that was operational at the European Centre for Medium-Range Weather Forecasts at the time. The focus was on weather parameters. Several configurations were tested. Besides perturbations that optimize total error growth for the European domain at 48 h, perturbations relevant for shorter forecast times were included as well. Firstly, in accordance with EPS, evolved northern hemispheric singular vectors (ETEPS) and secondly, targeted singular vectors with an optimization time of 12 h (STEPS) were added. Compared to EPS, ensemble spread was increased in the short range, having a beneficial effect on statistical properties such as reliability and the frequency of outliers. Spread-skill correlations improved as well. Best performance was found for the STEPS configuration. The impact on Brier scores, relative operating characteristic curves and cost-loss analyses was less clear. From the singular vector point of view, the positive impact of using targeted perturbations is evident. However, after integration (STEPS or ETEPS), it was difficult to find synoptic cases in which this clear impact is still present.

  4. Latvian natural gas system and its development

    The data presented in the paper evidence that natural gas consumption decreased from 2.91 billion m3 in 1991 to 0.95 in 1994, while in the period 1997-1999 it was levelled at about 1.3 billion m3. It is expected that there will be a gradual increase in natural gas consumption from 1.32 billion m:3 in 2001 to 1.95 billion m3 in 2005 mainly due to to development of co-generation stations and significant growth in the industrial sector. All the gas consumed in Latvia is imported from Russia during the summer period and injected into the Incukalns Underground Gas Storage for winter needs, in particular, for Latvian consumers as well as, partly, for Estonia and North-West of Russia. Latvia processes unique geological conditions for creation of a system of natural underground gas storage in the future with an active total volume of up to 50 billion m3. By integration of the Latvian underground gas storage system in the joint Russian - European gas transmission system, Latvia could become a major seasonal regulator of natural gas for Western regions of Russia and for Baltic Sea countries: Lithuania, Estonia, Finland, and Sweden. (author)

  5. Development of the environmental data management system

    The recent society requires business activities with environmental consideration to every enterprise. Also, Japanese laws require those activities. For example, 'Law Concerning the Promotion of Business Activities with Environmental Consideration by Specified Corporations, etc, by Facilitating Access to Environmental Information, and Other Measures' (Environmental Consideration Law) mandates publication of a report relating to the activities of environmental consideration to each enterprise above designated size. 'Act on the Rational Use of Energy' mandates the report of the results of energy consumption and the long-term plan of the rational use of energy. Moreover, 'Act on Promotion of Global Warming Countermeasures' mandates the report of the greenhouse gas emissions. In addition to those, 'Water Pollution Control Law', 'Waste Management and Public Cleaning Law' and other environmental laws as well as environmental ordinances require business activities with environmental consideration to all companies. So, it is very important for Japan Atomic Energy Agency (JAEA) to report business activities with environmental consideration in order to build up trustful relations with the nation and communities. The Environmental Data Management System has been developed as the data base of business activities with environmental consideration in JAEA and as the means to promote the activities at every site and office of JAEA. This report summarizes the structure of the Environmental Data Management System, kinds of environmental performance data treated by the system, and gathering methods of the data. (author)

  6. Development of Shimadzu digital subtraction system

    Shimadzu has recently developed a digital subtraction system. It can perform intra-arterial digital subtraction angiography (DSA) using low concentration of contrast medium, or can visualize arteries with intravenuous injection. It can extremely reduce patient's pain in angiography. Image quality of DSA has been much improved by the development of high quality image amplifiers, improvement of signal-to-noise ratio of the x-ray television unit and the development of digital disk recorders. The peak-hold subtraction method that is now under clinical study presents images of blood vessels as the trace of the flow of contrast medium. The maximum-hold memory where the maximum value of the brightness in some period is stored for every picture element is subtracted from the minimum-hold memory where the minimum value is stored, and thus images of blood vessels can be obtained. Hardware of this method is rather simple and it is expected that the amount of contrast medium may be reduced or x-ray dose of the patient may be decreased. (author)

  7. Development of novel emission tomography system

    Fu, Geng

    In recent years, small animals, such as mice and rats, have been widely used as subjects of study in biomedical research while molecular biology and imaging techniques open new opportunities to investigate disease model. With the help of medical imaging techniques, researchers can investigate underlying mechanisms inside the small animal, which are useful for both early diagnosis and treatment monitoring. Based on tracer principle single photon emission computed tomography (SPECT) has increased popularity in small animal imaging due to its higher spatial resolution and variety of single-photon emitting radionuclides. Since the image quality strongly depends on the detector properties, both scintillation and semiconductor detectors are under active investigation for high resolution X-ray and gamma ray photon detection. The desired detector properties include high intrinsic spatial resolution, high energy resolution, and high detection efficiency. In this thesis study, we have made extensive efforts to develop novel emission tomography system, and evaluate the use of both semiconductor and ultra-high resolution scintillation detectors for small animal imaging. This thesis work includes the following three areas. Firstly, we have developed a novel energy-resolved photon counting (ERPC) detector. With the benefits of high energy resolution, high spatial resolution, flexible detection area, and a wide dynamic range of 27--200keV, ERPC detector is well-suited for small animal SPECT applications. For prototype ERPC detector excellent imaging (˜350microm) and spectroscopic performance (4keV Co-57 122keV) has been demonstrated in preliminary study. Secondly, to further improve spatial resolution to hundred-micron level, an ultra-high resolution Intensified EMCCD (I-EMCCD) detector has been designed and evaluated. This detector consists of the newly developed electron multiplying CCD (EMCCD) sensor, columnar CsI(Tl) scintillator, and an electrostatic de-magnifier (DM) tube

  8. Development and Control of a Non Linear Magnetic Levitation System

    A Sanjeevi Gandhi

    2013-06-01

    Full Text Available Nowadays, studies to develop and control non linear systems is of great significance. Magnetic Levitation System has gained considerable interests due to its great practical importance in different engineering fields In this paper an electromagnetic levitation system was developed and mathematical model for the system was derived. The developed system was controlled manually.

  9. Development and Control of a Non Linear Magnetic Levitation System

    A Sanjeevi Gandhi; Reshma Angelene Jose

    2013-01-01

    Nowadays, studies to develop and control non linear systems is of great significance. Magnetic Levitation System has gained considerable interests due to its great practical importance in different engineering fields In this paper an electromagnetic levitation system was developed and mathematical model for the system was derived. The developed system was controlled manually.

  10. Geographic Information Systems and Web Page Development

    Reynolds, Justin

    2004-01-01

    The Facilities Engineering and Architectural Branch is responsible for the design and maintenance of buildings, laboratories, and civil structures. In order to improve efficiency and quality, the FEAB has dedicated itself to establishing a data infrastructure based on Geographic Information Systems, GIs. The value of GIS was explained in an article dating back to 1980 entitled "Need for a Multipurpose Cadastre which stated, "There is a critical need for a better land-information system in the United States to improve land-conveyance procedures, furnish a basis for equitable taxation, and provide much-needed information for resource management and environmental planning." Scientists and engineers both point to GIS as the solution. What is GIS? According to most text books, Geographic Information Systems is a class of software that stores, manages, and analyzes mapable features on, above, or below the surface of the earth. GIS software is basically database management software to the management of spatial data and information. Simply put, Geographic Information Systems manage, analyze, chart, graph, and map spatial information. At the outset, I was given goals and expectations from my branch and from my mentor with regards to the further implementation of GIs. Those goals are as follows: (1) Continue the development of GIS for the underground structures. (2) Extract and export annotated data from AutoCAD drawing files and construct a database (to serve as a prototype for future work). (3) Examine existing underground record drawings to determine existing and non-existing underground tanks. Once this data was collected and analyzed, I set out on the task of creating a user-friendly database that could be assessed by all members of the branch. It was important that the database be built using programs that most employees already possess, ruling out most AutoCAD-based viewers. Therefore, I set out to create an Access database that translated onto the web using Internet

  11. Development of Vertical Cable Seismic System

    Asakawa, E.; Murakami, F.; Sekino, Y.; Okamoto, T.; Ishikawa, K.; Tsukahara, H.; Shimura, T.

    2011-12-01

    In 2009, Ministry of Education, Culture, Sports, Science and Technology(MEXT) started the survey system development for Hydrothermal deposit. We proposed the Vertical Cable Seismic (VCS), the reflection seismic survey with vertical cable above seabottom. VCS has the following advantages for hydrothermal deposit survey. (1) VCS is an efficient high-resolution 3D seismic survey in limited area. (2) It achieves high-resolution image because the sensors are closely located to the target. (3) It avoids the coupling problems between sensor and seabottom that cause serious damage of seismic data quality. (4) Because of autonomous recording system on sea floor, various types of marine source are applicable with VCS such as sea-surface source (GI gun etc.) , deep-towed or ocean bottom source. Our first experiment of 2D/3D VCS surveys has been carried out in Lake Biwa, JAPAN, in November 2009. The 2D VCS data processing follows the walk-away VSP, including wave field separation and depth migration. Seismic Interferometry technique is also applied. The results give much clearer image than the conventional surface seismic. Prestack depth migration is applied to 3D data to obtain good quality 3D depth volume. Seismic Interferometry technique is applied to obtain the high resolution image in the very shallow zone. Based on the feasibility study, we have developed the autonomous recording VCS system and carried out the trial experiment in actual ocean at the water depth of about 400m to establish the procedures of deployment/recovery and to examine the VC position or fluctuation at seabottom. The result shows that the VC position is estimated with sufficient accuracy and very little fluctuation is observed. Institute of Industrial Science, the University of Tokyo took the research cruise NT11-02 on JAMSTEC R/V Natsushima in February, 2011. In the cruise NT11-02, JGI carried out the second VCS survey using the autonomous VCS recording system with the deep towed source provided by

  12. NASA's Space Launch System Development Status

    Lyles, Garry

    2014-01-01

    Development of the National Aeronautics and Space Administration's (NASA's) Space Launch System (SLS) heavy lift rocket is shifting from the formulation phase into the implementation phase in 2014, a little more than 3 years after formal program establishment. Current development is focused on delivering a vehicle capable of launching 70 metric tons (t) into low Earth orbit. This "Block 1" configuration will launch the Orion Multi-Purpose Crew Vehicle (MPCV) on its first autonomous flight beyond the Moon and back in December 2017, followed by its first crewed flight in 2021. SLS can evolve to a130t lift capability and serve as a baseline for numerous robotic and human missions ranging from a Mars sample return to delivering the first astronauts to explore another planet. Benefits associated with its unprecedented mass and volume include reduced trip times and simplified payload design. Every SLS element achieved significant, tangible progress over the past year. Among the Program's many accomplishments are: manufacture of core stage test barrels and domes; testing of Solid Rocket Booster development hardware including thrust vector controls and avionics; planning for RS- 25 core stage engine testing; and more than 4,000 wind tunnel runs to refine vehicle configuration, trajectory, and guidance. The Program shipped its first flight hardware - the Multi-Purpose Crew Vehicle Stage Adapter (MSA) - to the United Launch Alliance for integration with the Delta IV heavy rocket that will launch an Orion test article in 2014 from NASA's Kennedy Space Center. The Program successfully completed Preliminary Design Review in 2013 and will complete Key Decision Point C in 2014. NASA has authorized the Program to move forward to Critical Design Review, scheduled for 2015 and a December 2017 first launch. The Program's success to date is due to prudent use of proven technology, infrastructure, and workforce from the Saturn and Space Shuttle programs, a streamlined management

  13. Reliable Software Development for Machine Protection Systems

    Anderson, D; Dragu, M; Fuchsberger, K; Garnier, JC; Gorzawski, AA; Koza, M; Krol, K; Misiowiec, K; Stamos, K; Zerlauth, M

    2014-01-01

    The Controls software for the Large Hadron Collider (LHC) at CERN, with more than 150 millions lines of code, resides amongst the largest known code bases in the world1. Industry has been applying Agile software engineering techniques for more than two decades now, and the advantages of these techniques can no longer be ignored to manage the code base for large projects within the accelerator community. Furthermore, CERN is a particular environment due to the high personnel turnover and manpower limitations, where applying Agile processes can improve both, the codebase management as well as its quality. This paper presents the successful application of the Agile software development process Scrum for machine protection systems at CERN, the quality standards and infrastructure introduced together with the Agile process as well as the challenges encountered to adapt it to the CERN environment.

  14. Developing the SMF manipulator vehicle system

    After the Chernobyl accident, the experience accumulated there was incorporated in a list of specifications underlying the design and construction of a heavy-duty manipulator-vehicle, the tendering procedure for which, under the label of 'SMF', was opened in 1988. The vehicle is to be delivered to its operator in 1993 as the most powerful tool of its kind worldwide. SMF will meet the most stringent requirements with respect to dimensions, installed power, load bearing capacity, and precision. The electronic components of the control and data transmission systems in particular had to be developed from scratch. SMF is a mobile remotely controlled working tool which will be able to reach any location in and around nuclear installations and, in the process, will be able to handle with precision even the heaviest loads. (orig.)

  15. Development of Venturi System for Microbubble Generation

    This study was conducted with the aim of developing a venturi-type air supply system for a microbubble generator. In order to determine the influence of the varying geometry of the venturi tube on the flow characteristics, a computational fluid dynamics (CFD) simulation was performed using the commercial CFD software ANSYS CFX-15. Furthermore, in order to elucidate the effects of variation in major design dimensions such as the air supply hole size, position of holes, and number of holes on the air supply characteristics, two-phase multiflow CFD analysis was performed. The analysis results showed that the starting point of expansion on the venturi tube with 0.75 is the best hole position and that the air supply hole size and the number of holes are linearly proportional to the amount of air

  16. Development of CRD stub tube welding system

    The reactor pressure vessel (RPV) of nuclear power plants include control rod drive (CRD) stub tubes installed on the inner surface of the bottom head by welding. Weld seams are located at the root of each stub tube, to which accessibility is limited. The weld travel requires an elliptical movement with inclination along the inner bottom head surface, and furthermore the location on the bottom head of each stub tube has different angle of inclination. CRD stub tubes were installed by skilled welders using MIG welding in previous RPV construction. Recently, a CRD stub tube TIG welding system was developed for RPV construction in the near future, which can be applied to such 3 dimensional welding orbit. (author)

  17. Development of portable driving simulator system

    Y. Itoh

    2008-08-01

    Full Text Available Purpose: In accordance with aging of populations in many developed countries, number of drivers who suffer from mild cognitive impairment (MCI drivers is increasing. Since it has been reported that driving skill of the MCI drivers are deteriorated, it is important to train themselves in driving situation to preserve their driving skills. The present study was conducted to develop the simple driving simulator system, and to examine the effect of training in this system.Design/methodology/approach: Nineteen university students (8 males and 11 females participated in this study. After the habituation period (approximately 5min, three trials (approximately 12 min were conducted. Experimental situation imitated the real highway course. During trials, dangerous situation that would be resulted in car accident is randomly appeared and participants were required to avoid the car accidents. To avoid the possible car accidents are considered as correct response.Findings: Mean percent of correct responses for male and female were 75.2% and 56.6% in 1st trial and 95.7% and 72.6% in 3rd trial, respectively. Two-way analysis of variance revealed that the main effect of sex(F (1, 14 = 7.84, p < .05 and trials (F (2, 34 = 10.19, p < .001. These results indicate that numbers of car accidents are dramatically decreased and the driving skills of male are superior to that of female.Practical implications: Although the present study revealed the differences in driving skills between the sexes, their driving history was not considered. Driving history of each participant should be examined in future study.Originality/value: Since the improvement of driving skills is revealed, our experimental design is expected as the tool for the preservation of driving skills in the MCI drivers.

  18. Design and Development of Robot Hand System

    Panchumarthy Seetharamaiah

    2011-01-01

    Full Text Available Research on robot hand design is being carried out to accommodate a variety of tasks such as grasping and manipulation of objects in the field of industrial applications, service robots and rehabilitation robots. Problem statement: To design and develop a microcontroller-based four fingered robotic hand with a simple and minimal control strategy to pick and place application with object detection by simple IR sensor logic. Approach: The methodology is based on anthropomorphic design with three fingers and an opposing thumb. Each finger has three links and three double revolute joints. Each finger is actuated by a single opposing pair of tendons. The robot hand system is interfaced to microcontroller with software control by means of 14 independent commands for the motion of joints: close and open for fore finger, middle finger, ring finger and thumb finger and wrist up and down, base clockwise and counter clockwise, pick and place and home position. The tendoning system and wireless feedback logic provide the hand with the ability to confirm to object topology and therefore providing the advantage of using a simple control structure. Results: Reliable grasping and releasing is achieved with simple control mechanisms and IR sensors/push-button switches. The hand can pick a variety of objects with different surface characteristics and shapes without having to reconstruct its surface description. Picking of the object is successfully completed as long as the object is within the workspace of the hand and placed the object at the desired position within the workspace by relevant software control using keyboard commands. Conclusion: Hardware and software development of microcontroller-based four-fingered robotic hand is addressed. Details of hand control software for mainly pick and place applications are presented. Results of the experimental work for pick and place application of different objects is enumerated.

  19. MPs reminded of responsibilities

    2011-01-01

    Riigikogult valitsuse moodustamiseks volituse saanud peaminister Andrus Ansip tutvustas ministrikandidaate president Toomas Hendrik Ilvesele. Presidendi kõnest Riigikogu XII koosseisu avaistungil 4. apr. 2011

  20. The development of KAERI management information system (II) -The development of Time Sheet Management System-

    The purpose of this report is to describe the work done for the development, operation and maintenance of Time Sheet Management System. This work is a part of the development KAERI management information system. Manpower management is essential to cope with the external circumstances promptly and to maximize the productivity of the organization. This work aims at setting up a basis for the manpower management system. It is widely recognized that neither timely decision making nor competitive edge can be secured with the traditional management technology in so a rapidly changing situations home and abroad, which can be characterized by openness and informality. The necessity of efficient and scientific man-power management by time-study has emerged on the reorganization of KAERI by expanding matrix system in order to enhance the R and D productivity. (Author)

  1. Systems approach to nuclear waste glass development

    Development of a host solid for the immobilization of nuclear waste has focused on various vitreous wasteforms. The systems approach requires that parameters affecting product performance and processing be considered simultaneously. Application of the systems approach indicates that borosilicate glasses are, overall, the most suitable glasses for the immobilization of nuclear waste. Phosphate glasses are highly durable; but the glass melts are highly corrosive and the glasses have poor thermal stability and low solubility for many waste components. High-silica glasses have good chemical durability, thermal stability, and mechanical stability, but the associated high melting temperatures increase volatilization of hazardous species in the waste. Borosilicate glasses are chemically durable and are stable both thermally and mechanically. The borosilicate melts are generally less corrosive than commercial glasses, and the melt temperature miimizes excessive volatility of hazardous species. Optimization of borosilicate waste glass formulations has led to their acceptance as the reference nuclear wasteform in the United States, United Kingdom, Belgium, Germany, France, Sweden, Switzerland, and Japan

  2. BAE systems' SMART chip camera FPA development

    Sengupta, Louise; Auroux, Pierre-Alain; McManus, Don; Harris, D. Ahmasi; Blackwell, Richard J.; Bryant, Jeffrey; Boal, Mihir; Binkerd, Evan

    2015-06-01

    BAE Systems' SMART (Stacked Modular Architecture High-Resolution Thermal) Chip Camera provides very compact long-wave infrared (LWIR) solutions by combining a 12 μm wafer-level packaged focal plane array (FPA) with multichip-stack, application-specific integrated circuit (ASIC) and wafer-level optics. The key innovations that enabled this include a single-layer 12 μm pixel bolometer design and robust fabrication process, as well as wafer-level lid packaging. We used advanced packaging techniques to achieve an extremely small-form-factor camera, with a complete volume of 2.9 cm3 and a thermal core weight of 5.1g. The SMART Chip Camera supports up to 60 Hz frame rates, and requires less than 500 mW of power. This work has been supported by the Defense Advanced Research Projects Agency's (DARPA) Low Cost Thermal Imager - Manufacturing (LCTI-M) program, and BAE Systems' internal research and development investment.

  3. Information System on Occupational Exposure: Future Developments

    In response to pressures from deregulation and from ageing of the global nuclear power plant fleet, radiation protection personnel have found that occupational exposures are best managed through proper job planning, implementation and review to ensure that exposures are 'as low as reasonably achievable'(ALARA). A prerequisite for applying the principle of optimisation to occupational radiation protection is the timely exchange of data and information on dose reduction methods. To facilitate this global approach to work management, the OECD Nuclear Energy Agency (Nea) launched the Information System on Occupational Exposure (I.S.O.E.) in 1992. The objective of I.S.O.E. is to provide a forum for radiation protection experts from both utilities and national regulatory authorities to discuss, promote and coordinate international cooperative undertakings for the radiological protection of workers at nuclear power plants.The I.S.O.E. programme offers a variety of products in the occupational exposure area, such as: the world largest database on occupational exposure from nuclear power plants, a yearly analysis of dose trends and an overview of current developments, through I.S.O.E. Annual Reports, detailed studies, analyses, and information on current issues in operational radiation protection, through I.S.O.E. Information Sheets, a system for rapid communication of radiation protection-related information, such as effective dose reduction approaches and implementation of work management principles. A forum for discussing occupational exposure management issues through I.S.O.E. workshops, symposia and newsletters. (N.C.)

  4. Spontaneous activity in the developing auditory system.

    Wang, Han Chin; Bergles, Dwight E

    2015-07-01

    Spontaneous electrical activity is a common feature of sensory systems during early development. This sensory-independent neuronal activity has been implicated in promoting their survival and maturation, as well as growth and refinement of their projections to yield circuits that can rapidly extract information about the external world. Periodic bursts of action potentials occur in auditory neurons of mammals before hearing onset. This activity is induced by inner hair cells (IHCs) within the developing cochlea, which establish functional connections with spiral ganglion neurons (SGNs) several weeks before they are capable of detecting external sounds. During this pre-hearing period, IHCs fire periodic bursts of Ca(2+) action potentials that excite SGNs, triggering brief but intense periods of activity that pass through auditory centers of the brain. Although spontaneous activity requires input from IHCs, there is ongoing debate about whether IHCs are intrinsically active and their firing periodically interrupted by external inhibitory input (IHC-inhibition model), or are intrinsically silent and their firing periodically promoted by an external excitatory stimulus (IHC-excitation model). There is accumulating evidence that inner supporting cells in Kölliker's organ spontaneously release ATP during this time, which can induce bursts of Ca(2+) spikes in IHCs that recapitulate many features of auditory neuron activity observed in vivo. Nevertheless, the role of supporting cells in this process remains to be established in vivo. A greater understanding of the molecular mechanisms responsible for generating IHC activity in the developing cochlea will help reveal how these events contribute to the maturation of nascent auditory circuits. PMID:25296716

  5. Development of the excretory system in a polyplacophoran mollusc: stages in metanephridial system development

    Baeumler Natalie

    2012-09-01

    Full Text Available Abstract Background Two types of excretory systems, protonephridia and metanephridial systems are common among bilaterians. The homology of protonephridia of lophotrochozoan taxa has been widely accepted. In contrast, the homology of metanephridial systems – including coelomic cavities as functional units – among taxa as well as the homology between the two excretory systems is a matter of ongoing discussion. This particularly concerns the molluscan kidneys, which are mostly regarded as being derived convergently to the metanephridia of e.g. annelids because of different ontogenetic origin. A reinvestigation of nephrogenesis in polyplacophorans, which carry many primitive traits within molluscs, could shed light on these questions. Results The metanephridial system of Lepidochitona corrugata develops rapidly in the early juvenile phase. It is formed from a coelomic anlage that soon achieves endothelial organization. The pericardium and heart are formed from the central portion of the anlage. The nephridial components are formed by outgrowth from lateral differentiations of the anlage. Simultaneously with formation of the heart, podocytes appear in the atrial wall of the pericardium. In addition, renopericardial ducts, kidneys and efferent nephroducts, all showing downstream ciliation towards the internal lumen, become differentiated (specimen length: 0.62 mm. Further development consists of elongation of the kidney and reinforcement of filtration and reabsorptive structures. Conclusions During development and in fully formed condition the metanephridial system of Lepidochitona corrugata shares many detailed traits (cellular and overall organization with the protonephridia of the same species. Accordingly, we suggest a serial homology of various cell types and between the two excretory systems and the organs as a whole. The formation of the metanephridial system varies significantly within Mollusca, thus the mode of formation cannot be used

  6. Development of the excretory system in a polyplacophoran mollusc: stages in metanephridial system development

    2012-01-01

    Background Two types of excretory systems, protonephridia and metanephridial systems are common among bilaterians. The homology of protonephridia of lophotrochozoan taxa has been widely accepted. In contrast, the homology of metanephridial systems – including coelomic cavities as functional units – among taxa as well as the homology between the two excretory systems is a matter of ongoing discussion. This particularly concerns the molluscan kidneys, which are mostly regarded as being derived convergently to the metanephridia of e.g. annelids because of different ontogenetic origin. A reinvestigation of nephrogenesis in polyplacophorans, which carry many primitive traits within molluscs, could shed light on these questions. Results The metanephridial system of Lepidochitona corrugata develops rapidly in the early juvenile phase. It is formed from a coelomic anlage that soon achieves endothelial organization. The pericardium and heart are formed from the central portion of the anlage. The nephridial components are formed by outgrowth from lateral differentiations of the anlage. Simultaneously with formation of the heart, podocytes appear in the atrial wall of the pericardium. In addition, renopericardial ducts, kidneys and efferent nephroducts, all showing downstream ciliation towards the internal lumen, become differentiated (specimen length: 0.62 mm). Further development consists of elongation of the kidney and reinforcement of filtration and reabsorptive structures. Conclusions During development and in fully formed condition the metanephridial system of Lepidochitona corrugata shares many detailed traits (cellular and overall organization) with the protonephridia of the same species. Accordingly, we suggest a serial homology of various cell types and between the two excretory systems and the organs as a whole. The formation of the metanephridial system varies significantly within Mollusca, thus the mode of formation cannot be used as a homology criterion

  7. Diagnostics Systems for Permanent Hall Thrusters Development

    Ferreira, Jose Leonardo; Soares Ferreira, Ivan; Santos, Jean; Miranda, Rodrigo; Possa, M. Gabriela

    This work describes the development of Permanent Magnet Hall Effect Plasma Thruster (PHALL) and its diagnostic systems at The Plasma Physics Laboratory of University of Brasilia. The project consists on the construction and characterization of plasma propulsion engines based on the Hall Effect. Electric thrusters have been employed in over 220 successful space missions. Two types stand out: the Hall-Effect Thruster (HET) and the Gridded Ion Engine (GIE). The first, which we deal with in this project, has the advantage of greater simplicity of operation, a smaller weight for the propulsion subsystem and a longer shelf life. It can operate in two configurations: magnetic layer and anode layer, the difference between the two lying in the positioning of the anode inside the plasma channel. A Hall-Effect Thruster-HET is a type of plasma thruster in which the propellant gas is ionized and accelerated by a magneto hydrodynamic effect combined with electrostatic ion acceleration. So the essential operating principle of the HET is that it uses a J x B force and an electrostatic potential to accelerate ions up to high speeds. In a HET, the attractive negative charge is provided by electrons at the open end of the Thruster instead of a grid, as in the case of the electrostatic ion thrusters. A strong radial magnetic field is used to hold the electrons in place, with the combination of the magnetic field and the electrostatic potential force generating a fast circulating electron current, the Hall current, around the axis of the Thruster, mainly composed by drifting electrons in an ion plasma background. Only a slow axial drift towards the anode occurs. The main attractive features of the Hall-Effect Thruster are its simple design and operating principles. Most of the Hall-Effect Thrusters use electromagnet coils to produce the main magnetic field responsible for plasma generation and acceleration. In this paper we present a different new concept, a Permanent Magnet Hall

  8. Development of a system of programs HAMMER - ORIGEN - 2 system

    The development of a system of programs (Hamor-2) to calculate precision inventory of LWR reactors is presented. The Hamor-2 code generates with the Hammer-technion code the four (4) energy groupe effective cross section of the actinides: U-235, U-236, U-238, Pu-239, Pu-240, Pu-241, Pu-242. Hamor-2 collapses the four group energy effective cross section to one group energy effective cross section. Hamor-2 calculates with origen-2 the new concentrations for the actinides using the one group energy effective cross section. Two PWR reactors were analised. (HBR, KWO). The discrepancy between the final actinides conentration results calculated by Hamor-2 and the results of measures finded in the references were calculated. That discrepancies have been compared with the discrepancy between : the final actinide concentration results calculated by Origen-2 and some measured results finded in the references. (E.G.)

  9. Development of blood extraction system for health monitoring system

    Tsuchiya, Kazuyoshi; Nakanishi, Naoyuki; Nakamachi, Eiji

    2004-03-01

    The purpose of this research is to develop the compact human blood sampling device applied for a health monitoring system(HMS), which is called "Mobile Hospital". The HMS consists of (1) a micro electrical pumping system for blood extraction, (2) a bio-sensor to detect and evaluate an amount of Glucose, Cholesterol and Urea in extracted blood, by using enzyme such as Glucoseoxidase (GOD), Cholesteroloxidase and Urease. The mechanical design elements of the device are bio-compatible microneedle, indentation unit using a shape memory alloy(SMA) actuator and pumping unit using a piezoelectric microactuator. The design concept is the biomimetic micromachine of female mosquito"s blood sampling mechanism. The performances of the main mechanical elements such as indentation force of the microneedle, actual stroke of the indentation unit using a SMA actuator and liquid sampling ability of the pumping unit using PZT piezoelectric microactuator were measured. The 3 mm stroke of the indentation load generated by SMA actuator was 0.8mN. The amount of imitation blood extracted by using bimorph PZT actuators was about 0.5 microliters for 10 sec. A 60-micrometer outer diameter and 25-micrometer inner diameter Titanium microneedle, which size is same as female mosquito"s labium, was produced by sputter deposition.

  10. Development of the low energy linac systems

    The project 'Development of the Low Energy Linac System' is aiming to develop the 20 MeV proton linac system. This consists of a 50 keV proton injector, a 3 MeV RFQ, and a 20 MeV DTL. We obtained the first beam signal after the 20 MeV linac. The high power switch installed in the ion source supplies the pulsed beam into the following LEBT. The pulse operation was successfully tested. The main role of the LEBT is to match the beam into the 3 MeV RFQ. The total length of the four-vane type RFQ is about 3.26m. For the field stabilization, we used the resonant coupling scheme and dipole stabilizer rods. An 1 MW klystron supplies the RF power into the RFQ. After tuning, the field deviation of the quadrupole mode is less than 2% of the design value and the dipole fraction is less than 5% of the operating mode. The following accelerating structure is DTL which accelerate 20 mA proton beams up to 20 MeV. It consists of 4 tanks and the length of each tank is less than 5 m. The lattice is FFDD type and the integrated fields of the quadrupole magnets are 1.75 T. The inner walls of the tanks are copper-plated by PR plating method. The thickness is 100m with the roughness of 0.3m. Each drift tube consists of 6 parts and assembled by e-beam welding. The tanks and drift tubes are aligned under the installation limit of 50m by using the laser-tracker. The tuning by the slug tuners and post couplers results in the field uniformity of 2% and field sensitivity of 100%/MHz. In order to detect the beam signal, we installed the Faraday cup after the RFQ or the DTL. For the RFQ, we observed the beam of 12 A under the forward RF power of 450 kW. The beam current after DTL is about 0.5 A when RF power of 150 kW was fed into each tank

  11. Integrated System Health Management Development Toolkit

    Figueroa, Jorge; Smith, Harvey; Morris, Jon

    2009-01-01

    This software toolkit is designed to model complex systems for the implementation of embedded Integrated System Health Management (ISHM) capability, which focuses on determining the condition (health) of every element in a complex system (detect anomalies, diagnose causes, and predict future anomalies), and to provide data, information, and knowledge (DIaK) to control systems for safe and effective operation.

  12. Wind Development on Tribal Lands

    Ken Haukaas; Dale Osborn; Belvin Pete

    2008-01-18

    Background: The Rosebud Sioux Tribe (RST) is located in south central South Dakota near the Nebraska border. The nearest community of size is Valentine, Nebraska. The RST is a recipient of several Department of Energy grants, written by Distributed Generation Systems, Inc. (Disgen), for the purposes of assessing the feasibility of its wind resource and subsequently to fund the development of the project. Disgen, as the contracting entity to the RST for this project, has completed all the pre-construction activities, with the exception of the power purchase agreement and interconnection agreement, to commence financing and construction of the project. The focus of this financing is to maximize the economic benefits to the RST while achieving commercially reasonable rates of return and fees for the other parties involved. Each of the development activities required and its status is discussed below. Land Resource: The Owl Feather War Bonnet 30 MW Wind Project is located on RST Tribal Trust Land of approximately 680 acres adjacent to the community of St. Francis, South Dakota. The RST Tribal Council has voted on several occasions for the development of this land for wind energy purposes, as has the District of St. Francis. Actual footprint of wind farm will be approx. 50 acres. Wind Resource Assessment: The wind data has been collected from the site since May 1, 2001 and continues to be collected and analyzed. The latest projections indicate a net capacity factor of 42% at a hub height of 80 meters. The data has been collected utilizing an NRG 9300 Data logger System with instrumentation installed at 30, 40 and 65 meters on an existing KINI radio tower. The long-term annual average wind speed at 65-meters above ground level is 18.2 mph (8.1 mps) and 18.7 mph (8.4 mps) at 80-meters agl. The wind resource is excellent and supports project financing.

  13. NASA's Space Launch System: Development and Progress

    Honeycutt, John; Lyles, Garry

    2016-01-01

    NASA is embarked on a new era of space exploration that will lead to new capabilities, new destinations, and new discoveries by both human and robotic explorers. Today, the International Space Station (ISS), supported by NASA's commercial partners, and robotic probes, are yielding knowledge that will help make this exploration possible. NASA is developing both the Orion crew vehicle and the Space Launch System (SLS) that will carry out a series of increasingly challenging missions that will eventually lead to human exploration of Mars. This paper will discuss the development and progress on the SLS. The SLS architecture was designed to be safe, affordable, and sustainable. The current configuration is the result of literally thousands of trade studies involving cost, performance, mission requirements, and other metrics. The initial configuration of SLS, designated Block 1, will launch a minimum of 70 metric tons (t) into low Earth orbit - significantly greater capability than any current launch vehicle. It is designed to evolve to a capability of 130 t through the use of upgraded main engines, advanced boosters, and a new upper stage. With more payload mass and volume capability than any rocket in history, SLS offers mission planners larger payloads, faster trip times, simpler design, shorter design cycles, and greater opportunity for mission success. Since the program was officially created in fall 2011, it has made significant progress toward first launch readiness of the Block 1 vehicle in 2018. Every major element of SLS continued to make significant progress in 2015. The Boosters element fired Qualification Motor 1 (QM-1) in March 2015, to test the 5-segment motor, including new insulation, joint, and propellant grain designs. The Stages element marked the completion of more than 70 major components of test article and flight core stage tanks. The Liquid Engines element conducted seven test firings of an RS-25 engine under SLS conditions. The Spacecraft

  14. Beam developments for the Harwell microprobe system

    A consequence of the rapid development of micron and submicron size electronic devices is the diminished applicability of high energy ion microprobes with their present resolution limitations to the study of such components. Although submicron beams have been reported the available beam current is barely sufficiently for PIXE and is not adequate for RBS. This lack of lateral resolution is due to low beam brightness at the microprobe object and aberrations in the focussing elements. As part of a program to address these problems the Harwell microprobe lens has been relocated on a new 5 MV Laddertron accelerator. The increased brightness and improved stability of this facility has so far led to a reduction in beam size from 3x3 μm2 to about 2x2 μm2. The feasibility of using a liquid metal ion source has been examined with a view to achieving more substantial increases in brightness. While such sources have brightness approximately 105 times greater than conventional gaseous sources the highly divergent nature of the beam presents problems for the beam transport system. The use of a liquid metal source on the accelerator has been successfully demonstrated but it indicates the need for a special low aberration injection lens if brightness is to be maintained. (orig.)

  15. Beam developments for the Harwell microprobe system

    A consequence of the rapid development of micron and submicron size electronic devices is the diminished applicability of high energy ion microprobes with their present resolution limitations to the study of such components. Although submicron beams have been reported the available beam current is barely sufficiently for PIXE and is not adequate for RBS. This lack of lateral resolution is due to low beam brightness at the microprobe object and aberrations in the focusing elements. As part of a program to address these problems the Harwell microprobe lens has been relocated on a new 5 MV Laddertron accelerator. The increased brightness and improved stability of this facility has so far led to a reduction in beam size from 3 x 3 μm2 to about 2 x 2 μm2. The feasibility of using a liquid metal ion source has been examined with a view to achieving more substantial increases in brightness. While such sources have brightness approximately 105 times greater than conventional gaseous sources the highly divergent nature of the beam presents problems for the beam transport system. The use of a liquid metal source on the accelerator has been successfully demonstrated but it indicates the need for a special low aberration injection lens if brightness is to be maintained

  16. Development of oxide fibrous monolith systems.

    Goretta, K. C.

    1999-03-02

    Fibrous monolithic ceramics generally have a cellular structure that consists of a strong cell surrounded by a weaker boundary phase [1-5]. Fibrous monoliths (FMs) are produced from powders by conventional ceramic fabrication techniques, such as extrusion [1,2]. When properly engineered, they exhibit fail gracefully [3-5]. Several compositions of ceramics and cermets have been processed successfully in fibrous monolithic form [4]. The most thoroughly investigated fibrous monolith consists of Si{sub 3}N{sub 4} cells and a BN cell-boundary phase [3-5]. Through appropriate selection of initial powders and extrusion and hot-pressing parameters, very tough final products have been produced. The resultant high toughness is due primarily to delamination during fracture along textured platelike BN grains. The primary objectives of our program are to develop: (1) Oxide-based FMs, including new systems with improved properties; (2) FMs that can be pressureless sintered rather than hot-pressed; (3) Techniques for continuous extrusion of FM filaments, including solid freeform fabrication (SFF) for net-shape fabrication of FMs; (4) Predictive micromechanical models for FM design and performance; and (5) Ties with industrial producers and users of FMs.

  17. Development of European urban tourist systems

    Jerković Senta

    2009-01-01

    Relationship between urban development and tourism is a significant process in Europe today. Development of tourism has caused many organizational changes in urban environment. In the middle of the 20th century cultural and historical heritage in the cities was impetus of development of tourism in European cities. Nowadays, in many European cities tourism is recognized as a mean of further economic development. Strategy of polycentricity, outlined in European spatial development perspective i...

  18. Innovation ways on research and technical development system

    This book tells US innovation ways for research and technical development system, which mentions meaning and conception of research and development systematization system structure with principle, technology and structure, meaning of system management of R and D, effectiveness of R and D system, optimal type of R and D system, form of R and D system and support system, location and communication of R and D, innovation way of R and D system with propel ways and feature and R and D system structure internationalization of R and D system and strategy case and R and D system in the U.S and Japan. 635

  19. A decision support system for stress only myocardial perfusion scintigraphy may save unnecessary rest studies

    Tägil, K; Jakobsson, D; Lomsky, M;

    2013-01-01

    The aim of this study was to investigate the influence of a computer-based decision support system (DSS) on performance and inter-observer variability of interpretations regarding ischaemia and infarction in myocardial perfusion scintigraphy (MPS).......The aim of this study was to investigate the influence of a computer-based decision support system (DSS) on performance and inter-observer variability of interpretations regarding ischaemia and infarction in myocardial perfusion scintigraphy (MPS)....

  20. Extended professional development for systemic curriculum reform

    Kubitskey, Mary Elizabeth

    Education standards call for adopting inquiry science instruction. Successful adoption requires professional development (PD) to support teachers, increasing the need for research on PD. This dissertation examines the question: What is the influence of high quality, curriculum aligned, long-term group workshops and related practice on teacher learning? I focus on the following subquestions: (1) What is the influence of high quality, curriculum aligned, long-term, group workshops on teacher knowledge and beliefs? (2) What is the impact of the workshops on teacher practice? (3) What is the influence of practice on student response? (4) What is the impact of practice and student response on teacher knowledge and beliefs? I focus on an instance of PD nested within a long-term systemic change initiative, tracing eleven science teachers' learning from workshops and associated enactments. The data included pre and post-unit interviews (n=22), two post-workshop interviews (n=17), workshop observations (n=2), classroom observations (n=24) and student work (n=351). I used mixed-methods analysis. Quantitative analysis measured teacher learning by comparing pre and post-unit interview ratings. Qualitative components included two case study approaches: logic model technique and cross-case synthesis, examining teacher learning within and across teachers. The findings suggested a teacher-learning model incorporating PD, teacher knowledge, beliefs, practice and student response. PD impacts teachers' knowledge by providing teachers with new knowledge, adapting previous knowledge, or convincing them to value existing knowledge they chose not to use. The workshops can influence beliefs, providing teachers with confidence and motivation to adopt the practice. Beliefs can mediate how knowledge manifested itself in practice that, in turn, impacts students' response. Student response influences the teachers' beliefs, either reinforcing or motivating change. This teacher-learning model

  1. The development of KAERI management information system -First year: The development of manpower information management system-

    The purpose of this report is to describe the implementation of the management information system for manpower. This job is the first year's for development KAERI management information system. It is important to properly manage a manpower to cope with the external circumstances promptly and to maximize the productivity of the organization. This report aims at basic management of manpower and uses multimedia to keep abreast with the times and introduces the concept of GUI (Graphic User Interface) to user for ease access. (Author)

  2. Land system science and sustainable development of the earth system

    Verburg, Peter H.; Crossman, Neville; Ellis, Erle C.;

    2015-01-01

    Land systems are the result of human interactions with the natural environment. Understanding the drivers, state, trends and impacts of different land systems on social and natural processes helps to reveal how changes in the land system affect the functioning of the socio-ecological system as a ...

  3. Integrated approach to optomechanical system development

    Reney, Thomas E.; Wiggins, Richard L.; Comstock, Lovell E.; Santman, Jeffry J.; Woodard, Kenneth S.

    2011-06-01

    Over the past few decades of computer aided engineering growth there has been much more progress in increasing the power and capability of function specific engineering tools (e.g., optical design, finite element analysis, etc.) than in the integration of and communication between these tools. With only a few notable exceptions, such as FEA being imbedded into solid modeling, the communication method between the function specific tools continues to be dominated by translation to neutral data formats (e.g., IGES, STEP) and file transfer. There are a number of problems with this approach. The translation is a serial process where an engineer has to stop at some point in the design, make the neutral file, send that file to the next function, and wait for feedback. The translation through a neutral format is typically one way so the whole translation process has to be repeated when changes are required. Revision tracking of multiple files for each design iteration is both critical and a likely source of errors. Also, as with any translation, some information is always lost or corrupted in the process. This paper describes some progress that has been made in more tightly integrating optical design, mechanical design, fabrication, and testing of optical systems. Tools have been developed that connect CODE V®[1] to SolidWorks®[2] (bidirectional), compensation of diamond turning CNC from interferometric data, slope analysis from interferometer and profilometer data, and other tools for wavefront error compensation, and electronic nulls. Design, machining, testing and inspection efficiency gains are achieved through tools that consume mechanical solid models in their native format.

  4. Development of a PSA information management system

    In general, Probabilistic Safety Agreement (PSA) is a very complicated work that uses and generates a lot of resources such as reports, procedures, drawings, assumptions, calculation sheets, PSA model, and so on. In many PSAs, however, the data, materials and knowledge considered and generated during performing PSA are scattered in many documents so that overall structure of PSA and information relationship between documents and models cannot easily be understood. To organize and manage all documents related to PSA, to capture knowledge of analysts, and finally to improve the quality of PSA, a PSA information management system (PIMS) was developed. The PIMS can manage all the documents of a PSA in a database and connect the causal relation between one information to another in the scattered documents via link. The PIMS can manage all the assumptions and technical basis used in PSA, and it can keep the record of the design changes the revision of PSA model. It can also control the review results of PSA models. The link of the PIMS can explicitly describe and reveal the expertise of the PSA analysts, and it enables the users to capture the knowledge and to understand the structure and contents of a PSA with ease. We are planning to apply the PIMS to the PSA of Shin Kori Units 1 and 2 as feasibility study and then to all the PSAs of the nuclear power plants in Korea. The PIMS is expected to contribute to enhancing the quality and confidence of PSA and reducing the efforts and costs of maintenance and update of PSA. (authors)

  5. Development of a PSA information management system

    Ho, Seok; Dong Kyu, Kim; Sun Koo, Kang [Korea Power Engineering Company, Inc (Korea, Republic of)

    2007-07-01

    In general, Probabilistic Safety Agreement (PSA) is a very complicated work that uses and generates a lot of resources such as reports, procedures, drawings, assumptions, calculation sheets, PSA model, and so on. In many PSAs, however, the data, materials and knowledge considered and generated during performing PSA are scattered in many documents so that overall structure of PSA and information relationship between documents and models cannot easily be understood. To organize and manage all documents related to PSA, to capture knowledge of analysts, and finally to improve the quality of PSA, a PSA information management system (PIMS) was developed. The PIMS can manage all the documents of a PSA in a database and connect the causal relation between one information to another in the scattered documents via link. The PIMS can manage all the assumptions and technical basis used in PSA, and it can keep the record of the design changes the revision of PSA model. It can also control the review results of PSA models. The link of the PIMS can explicitly describe and reveal the expertise of the PSA analysts, and it enables the users to capture the knowledge and to understand the structure and contents of a PSA with ease. We are planning to apply the PIMS to the PSA of Shin Kori Units 1 and 2 as feasibility study and then to all the PSAs of the nuclear power plants in Korea. The PIMS is expected to contribute to enhancing the quality and confidence of PSA and reducing the efforts and costs of maintenance and update of PSA. (authors)

  6. Development of a library for interprocess communication in interactive systems

    ŠKVORC, URBAN

    2015-01-01

    The goal of the diploma thesis was to develop a simple and efficient interprocess communication system for the Linux operating system. The developed system gives developers a simple to use process for sharing information between multiple running processes. It uses a publish/subscribe model, which enables easier organization of messages. The developed system uses Linux sockets, which allow for efficient one-to-one data transfer. It is based on a central process which runs in the background and...

  7. Standardization of information systems development processes and banking industry adaptations

    Tuna Ozcer; Zuhal Tanrikulu

    2011-01-01

    This paper examines the current system development processes of three major Turkish banks in terms of compliance to internationally accepted system development and software engineering standards to determine the common process problems of banks. After an in-depth investigation into system development and software engineering standards, related process-based standards were selected. Questions were then prepared covering the whole system development process by applying the classical Waterfall l...

  8. Information System Development in the Small Firm

    Gavin C Reid

    2000-01-01

    This paper argues that the informational requirements for good decision making in small and medium sized enterprises (SMEs) are complex and adaptive. It identifies the basic information needs of the SME, and considers how information is used to guide decisions. It argues that accounting information systems (AIS) and, in particular, management accounting systems (MAS), best characterise successful information systems implementation in the SME. The paper examines the relationship between AIS de...

  9. Matching technology developments to system requirements

    Smith, D.; Byzery, B.; Delhaye, E.; Buck, C.

    1998-01-01

    In the field of telecommunications, the applications for GaAs MMIC's beyond 2000 will include today's drivers such as Cellular and Portable Telephones, Direct Broadcast Systems and CATV distribution, but also the emerging markets of multimedia satellite communications, broadband Wireless Services, and high bit rate optical fibre systems. These latter systems use millimetre wave carrier frequencies, typically ranging from 10 GHz to 80 GHz. The full paper will look at the requirements which hav...

  10. Development of Traction Drive Motors for the Toyota Hybrid System

    Kamiya, Munehiro

    Toyota Motor Corporation developed in 2005 a new hybrid system for a large SUV. This system included the new development of a high-speed traction drive motor achieving a significant increase in power weight ratio. This paper provides an overview of the hybrid system, discusses the characteristics required of a traction drive motor, and presents the technologies employed in the developed motor.

  11. GST Revisited: Working Systems Principles for Training and Development Consultants.

    Owens, Elizabeth

    1990-01-01

    Presents seven principles for applying technology to training and development problems. Based on General Systems Theory (GST), these principles were developed to help with long-term decisions. Highlights include instructional systems development models; complexity in cultural systems; matching training materials to user characteristics; systems…

  12. Systems design and engineering : facilitating multidisciplinary development projects

    Bonnema, G. Maarten; Veenvliet, Karel Th.; Broenink, Jan F.

    2016-01-01

    As its name implies, the aim of Systems Design and Engineering: Facilitating Multidisciplinary Development Projects is to help systems engineers develop the skills and thought processes needed to successfully develop and implement engineered systems. Such expertise typically does not come through st

  13. Potential Development of Vehicle Traction Levitation Systems with Magnetic Suspension

    A.V. Kireev; N.M. Kozhemyaka; G.N. Kononov

    2015-01-01

    Below is given the brief analysis of development trend for vehicle traction levitation systems with magnetic suspension. It is presented the assessment of potential development of traction levitation systems in terms of their simplicity. The examples are considered of technical solutions focused on reducing the complexity of transport systems. It is proposed the forecast of their further development.

  14. Potential Development of Vehicle Traction Levitation Systems with Magnetic Suspension

    A.V. Kireev

    2015-03-01

    Full Text Available Below is given the brief analysis of development trend for vehicle traction levitation systems with magnetic suspension. It is presented the assessment of potential development of traction levitation systems in terms of their simplicity. The examples are considered of technical solutions focused on reducing the complexity of transport systems. It is proposed the forecast of their further development.

  15. Development of a Relational Database for Learning Management Systems

    Deperlioglu, Omer; Sarpkaya, Yilmaz; Ergun, Ertugrul

    2011-01-01

    In today's world, Web-Based Distance Education Systems have a great importance. Web-based Distance Education Systems are usually known as Learning Management Systems (LMS). In this article, a database design, which was developed to create an educational institution as a Learning Management System, is described. In this sense, developed Learning…

  16. THE ISSUE OF A FUZZY EXPERT SYSTEM DEVELOPMENT

    Laptev V. N.

    2015-12-01

    Full Text Available The article considers questions of the information system of choice of development tools of automated systems based on fuzzy logic model. The technique allows us to develop information systems in an objectoriented programming language. Information system allows selecting the most effective tool without additional researches

  17. Development of a Portable Muon Witness System

    Aguayo Navarrete, Estanislao; Kouzes, Richard T.; Orrell, John L.

    2011-01-01

    Since understanding and quantifying cosmic ray induced radioactive backgrounds in copper and germanium are important to the MAJORANA DEMONSTRATOR, methods are needed for monitoring the levels of such backgrounds produced in materials being transported and processed for the experiment. This report focuses on work conducted at Pacific Northwest National Laboratory to develop a muon witness system as a one way of monitoring induced activities. The operational goal of this apparatus is to characterize cosmic ray exposure of materials. The cosmic ray flux at the Earth’s surface is composed of several types of particles, including neutrons, muons, gamma rays and protons. These particles induce nuclear reactions, generating isotopes that contribute to the radiological background. Underground, the main mechanism of activation is by muon produced spallation neutrons since the hadron component of cosmic rays is removed at depths greater than a few tens of meters. This is a sub-dominant contributor above ground, but muons become predominant in underground experiments. For low-background experiments cosmogenic production of certain isotopes, such as 68Ge and 60Co, must be accounted for in the background budgets. Muons act as minimum ionizing particles, depositing a fixed amount of energy per unit length in a material, and have a very high penetrating power. Using muon flux measurements as a “witness” for the hadron flux, the cosmogenic induced activity can be quantified by correlating the measured muon flux and known hadronic production rates. A publicly available coincident muon cosmic ray detector design, the Berkeley Lab Cosmic Ray Detector (BLCRD), assembled by Juniata College, is evaluated in this work. The performance of the prototype is characterized by assessing its muon flux measurements. This evaluation is done by comparing data taken in identical scenarios with other cosmic ray telescopes. The prototype is made of two plastic scintillator paddles with

  18. Developing a Small Business Regulatory System

    Geoff Miller

    2014-09-01

    Full Text Available IntroductionThank you for inviting me to share my thoughts on what the government is doing to reduce the burden on small business. I also look forward to hearing the other speakers talk about how to make the regulatory system more responsive and relevant to business needs.It is more than a year since the fall of Lehman Brothers and the beginning of the Australian Government’s response to the global financial crisis.Today, the Australian economy is showing encouraging signs of recovery. The Government’s policy responses have been largely responsible for placing Australia in a better position than most countries around the world.The Mid-Year Economic and Fiscal Outlook (MYEFO (released earlier this month showed that the economy is performing much better than was forecast in the last Budget — MYEFO shows that Australia is the only advanced economy to have recorded positive growth through the year to June 2009. MYEFO also upgraded the growth forecasts for the following two years with consequental falls in the expected peak unemployment rate.Although this is good news, the GFC has clearly affected, and is continuing to impact on, small business.A number of Australian Chamber of Commerce and Industry surveys have reported large falls in small business confidence and conditions throughout 2008 and early 2009. However, the August ACCI Small Business Survey reports that, while conditions for small business are expected to remain challenging, conditions are stabilising.This good news is supported by the most recent Commonwealth Bank – ACCI Business Expectations Survey, which shows that small, medium and large businesses are expecting business conditions to improve significantly during this quarter.It is true that small businesses succeed or fail on the creativity, ingenuity, innovation and imagination of their owners and staff. It is also true that small businesses are notoriously time poor. When considering ways to improve the regulatory

  19. Development of a system for safety indicators

    This R and D effort was carried out to support the introduction of safety performance indicators (SPIs) for the SKI inspections. The main goal was to compile and evaluate indicators currently in use by the Swedish utilities, and those proposed by the SKI. The main parts of the work performed were: - a compilation of safety performance indicators used by the utilities and those proposed by the SKI; - an assessment of selected important attributes for each SPI; - a description of the data collection processes; - an evaluation of how the currently used SPIs cover the various focus areas of the SKI yearly safety performance assessments for the plants; - a proposal of which SPIs to use for the 2002 assessments; - participation in reference group meetings. The utilities have used SPIs since the early 1990s. SPIs are regularly calculated and presented at plants and at corporate offices, and the SPIs are today an integrated part of the management systems. The selection of SPIs is based both on the WANO SPIs and on SPIs defined by the users themselves. The compilation shows that the utilities currently use well over 20 SPIs for follow-up of safety at the plants, including all of the 8 WANO SPIs. A SKI pilot project has proposed a number of SPIs for internal use. The basis is the reporting requirements according to regulations in SKIFS 1998:1, with its barrier- and defence-in-depth principles. A first implementation is planned for the 2002 safety assessments of plant performance. The SKI has in the report proposed use of 9 groups of SPIs. Several are identical or similar to those used by the utilities. An analysis of the data extracted from the SKI LER database STAGBAS implies some quality assurance problems i.e. data are not easily re-created. The data base itself though should be well fit for the application. Users within the Vattenfall group perform various aggregations of the SPIs, while others so far have only presented indicator data for the individual SPIs. Several of

  20. Systems design methodology to develop chrysanthemum growing systems

    Blok, C.; Vermeulen, T.

    2012-01-01

    When chrysanthemum growers change soil for a soilless growing system they aim for labour cost reduction, quality and yield improvement and reduced emissions of nutrients. Because many attempts to come up with a viable soilless system failed, improvements and systemizations of the design process were

  1. Development of European urban tourist systems

    Jerković Senta

    2009-01-01

    Full Text Available Relationship between urban development and tourism is a significant process in Europe today. Development of tourism has caused many organizational changes in urban environment. In the middle of the 20th century cultural and historical heritage in the cities was impetus of development of tourism in European cities. Nowadays, in many European cities tourism is recognized as a mean of further economic development. Strategy of polycentricity, outlined in European spatial development perspective is supporting that process, too. Many tourist centres and metropolitan tourist areas have been developed. In the period from 1996. to 2007. number of visitors in European cultural capitals was growing continuously by rate of 25,6%. In the same period, the number of international tourist arrivals increased by rate of only 7%.

  2. DEVELOPMENT OF A GENERIC RECOMMENDER SYSTEM

    Dan Munteanu

    2004-12-01

    Full Text Available his paper presents a recommender system for textual documents taken from web (given as bookmarks. The system uses for classification a combination of content, event and collaborative filters and for recommendation a modified Pearson-r algorithm. It uses implicit and explicit feedback for evaluating documents.

  3. Requirements development for a patient computing system.

    Wald, J. S.; Pedraza, L. A.; Reilly, C. A.; Murphy, M. E.; Kuperman, G. J.

    2001-01-01

    Critical parts of the software development life cycle are concerned with eliciting, understanding, and managing requirements. Though the literature on this subject dates back for several decades, practicing effective requirements development remains a current and challenging area. Some projects flourish with a requirements development process (RDP) that is implicit and informal, but this approach may be overly risky, particularly for large projects that involve multiple individuals, groups, a...

  4. Conceptualizing emotion in information systems development

    Stacey, Patrick; Chiasson, Mike

    2014-01-01

    The purpose of this theory paper is to develop a contextual theory of appraisal that may be drawn on to understand emotional processes in IS development (ISD). In short, emotion matters to ISD because managers/professionals lack capacity in dealing with emotionality whether positively or negatively, and there are very few ISD studies that directly focus on emotion. We develop a theoretical lens by inductively examining the substance and intellectual heritage of four emotion theory streams: fe...

  5. Marshall Space Flight Center Ground Systems Development and Integration

    Wade, Gina

    2016-01-01

    Ground Systems Development and Integration performs a variety of tasks in support of the Mission Operations Laboratory (MOL) and other Center and Agency projects. These tasks include various systems engineering processes such as performing system requirements development, system architecture design, integration, verification and validation, software development, and sustaining engineering of mission operations systems that has evolved the Huntsville Operations Support Center (HOSC) into a leader in remote operations for current and future NASA space projects. The group is also responsible for developing and managing telemetry and command configuration and calibration databases. Personnel are responsible for maintaining and enhancing their disciplinary skills in the areas of project management, software engineering, software development, software process improvement, telecommunications, networking, and systems management. Domain expertise in the ground systems area is also maintained and includes detailed proficiency in the areas of real-time telemetry systems, command systems, voice, video, data networks, and mission planning systems.

  6. Towards a sustainable system of drug development

    Moors, Ellen H.M.; Cohen, Adam F.; Schellekens, Huub

    2014-01-01

    Drug development has become the exclusive activity of large pharmaceutical companies. However, the output of new drugs has been decreasing for the past decade and the prices of new drugs have risen steadily, leading to access problems for many patients. By analyzing the history of drug development a

  7. Communication Development of Preschool Children with Insufficient Development of Language System

    Cupere, Irina

    2015-01-01

    This article explores communication development of preschool children with insufficient development of the language system. Children who have speech and language disorders have problems with interaction between persons in society, because they have poor narrative skills. Theoretical aspect is analyzed about communication development differences in preschool children with normal language development and with insufficient development of the language system.

  8. An approach for the development of visual configuration systems

    Hvam, Lars; Ladeby, Klaes Rohde

    2007-01-01

    by Centre for Product Modelling (CPM) at The Technical University of Denmark. The approach is based on experiences from a visualization project in co-operation between CPM and the global provider of power protection American Power Conversion (APC). The visual configuration system was developed in......How can a visual configuration system be developed to support the specification process' in companies that manufacture customer tailored products? This article focuses on how visual configuration systems can be developed. The approach for developing visual configuration systems has been developed...... visualization of the product in the visual configuration system....

  9. Embed XRF Data Processing System Development

    This paper introduced a project of XRF data processing system. The project adopted embed processor LPC2148 as the core of the data processing. This System has equipped graph LCD and the number of dots is 320 x 240. The large capacity Secure Digital Memory Card has been used as Data memory. It could exchange data with PC by USB interface. Also, we have made some amelioration on the function of XRF data processing. This system running stably, capability credibility and using conveniently, so it has good prospect of application and extension. (authors)

  10. Radioisotope Power Systems Technology Development Project

    National Aeronautics and Space Administration — Radioisotope Power Systems (RPS) is a multicenter, multiagency (with the Department of Energy (DOE)) program whose purpose is to manage the Science Mission...

  11. Automatic Tracking Evaluation and Development System (ATEDS)

    Federal Laboratory Consortium — The heart of the ATEDS network consists of four SGI Octane computers running the IRIX operating system and equipped with V12 hardware graphics to support synthetic...

  12. The Systems Engineering Process for Human Support Technology Development

    Jones, Harry

    2005-01-01

    Systems engineering is designing and optimizing systems. This paper reviews the systems engineering process and indicates how it can be applied in the development of advanced human support systems. Systems engineering develops the performance requirements, subsystem specifications, and detailed designs needed to construct a desired system. Systems design is difficult, requiring both art and science and balancing human and technical considerations. The essential systems engineering activity is trading off and compromising between competing objectives such as performance and cost, schedule and risk. Systems engineering is not a complete independent process. It usually supports a system development project. This review emphasizes the NASA project management process as described in NASA Procedural Requirement (NPR) 7120.5B. The process is a top down phased approach that includes the most fundamental activities of systems engineering - requirements definition, systems analysis, and design. NPR 7120.5B also requires projects to perform the engineering analyses needed to ensure that the system will operate correctly with regard to reliability, safety, risk, cost, and human factors. We review the system development project process, the standard systems engineering design methodology, and some of the specialized systems analysis techniques. We will discuss how they could apply to advanced human support systems development. The purpose of advanced systems development is not directly to supply human space flight hardware, but rather to provide superior candidate systems that will be selected for implementation by future missions. The most direct application of systems engineering is in guiding the development of prototype and flight experiment hardware. However, anticipatory systems engineering of possible future flight systems would be useful in identifying the most promising development projects.

  13. An expert system for logistics force development

    Chadwick, Robert Lawrence

    1987-01-01

    Approved for public release; distribution is unlimited The purpose of this research is to show the feasibility of an expert system to aid logistics planners in determining the types and numbers of logistics units needed to support corps contingency plans. The proposed system represents the domain knowledge of logistics planners as rules and uses backwards chaining to infer the types and numbers of logistics units needed. Next a chain of command, represented as a tree diagram...

  14. An Interoperability Infrastructure for Developing Multidatabase Systems

    Doğaç, Asuman; Özhan, Gökhan; Kılıç, Ebru; Özcan, Fatma; Nural, Sena; Sema

    1998-01-01

    A multidatabase system (MDBS) allows the users to simultaneously access autonomous, heterogeneous databases using a single data model and a query language. This provides for achieving interoperability among heterogeneous, federated DBMSs. In this paper, we describe the interoperability infrastructure of a multidatabase system, namely METU Interoperable DBMS (MIND). The architecture of MIND is based on OMG distributed object management model. It is implemented on top of a CORBA compl...

  15. The development of credit report information system

    Pristavec, Jošt

    2011-01-01

    Credit Report Information System is a unified, complex web application designed to work with the data of Slovenian companies. A credit system is for the analyst to view and edit either general information about companies, such as name, address, tax identification number, agents, etc. or financial data, balances, credit reports, etc. The main functionality of applications is the possibility of creating a credit rating for each company and the possibility to export a credit rating as a report. ...

  16. Development of a relational database management system

    Ruiz, Anabel Natalia; Maldonado, Calixto; Martínez Spessot, Cesar Ignacio

    2003-01-01

    The studies of Relational Data Base Management Systems and Databases constitute nowadays a main tren of investigation in large businesses and universities of the entire world. The creation of a data base engine keeps being a challenge since there are aspects in which have not been achieved a final solution. Por example, the requeriments of storage of images, video, sound. etc. The purpuse of this project is to implement a Relational Database Manager System (RDBMS) and an Interpreter of Data Q...

  17. Artificial heart system thermal insulation component development

    A concentric cup vacuum multifoil insulation system has been selected by virtue of its size, weight, and thermal performance to insulate the hot radioisotope portion of the thermal converter of an artificial implantable heart system. A factor of 2 improvement in thermal performance, based on the heat loss per number of foil layers (minimum system weight and volume) has been realized over conventional spiral wrapped multifoil vacuum insulation. This improvement is the result of the concentric cup construction to maintain a uniform interfoil spacing and the elimination of corner heat losses. Based on external insulation system dimensions (surface area in contact with host body), heat losses of 0.019 W/ cm2 at 11400K (16000F) and 0.006 W/cm2 at 9200K (12000F) have been achieved. Factors which influence thermal performance of the nickel foil concentric cup insulation system include the number of cups, configuration and method of application of zirconia (ZrO2) spacer material, system pressure, emittance of the cups, and operating temperature

  18. Developing a Frame of Reference for understanding configuration systems

    Ladeby, Klaes Rohde; Edwards, Kasper

    This paper uses the theory of technical systems to develop a frame of reference of product configuration systems. Following a definition of the configuration task, product model and product configuration system the theory of technical systems are presented. Configuration systems are then related ...

  19. Radiation risks to the developing nervous system

    The present abstract book contains the abstracts of 23 papers presented at the meeting. They are dealing with the effect of pre- or postnatal irradiation on the brain morphology metabolism or development studied in mice, rats or rabbits. (MG)

  20. Development of recirculating RF pulse compression system

    An RF pulse compression technique using recirculating resonant cavity is under development for accelerating energy reinforcement for KEK B-factory. Cavity design and fabrication of cold model are described. (author)