WorldWideScience
 
 
1

MPS Data Acquisition System  

International Nuclear Information System (INIS)

[en] A description is given of the data acquisition system used with the multiparticle spectrometer facility at Brookhaven. Detailed information is provided on that part of the system which connects the detectors to the data handler; namely, the detector electronics, device controller, and device port optical isolator

1975-01-01

2

The APS machine protection system (MPS)  

Energy Technology Data Exchange (ETDEWEB)

The machine protection system (MPS) that protects the APS storage ring vacuum chamber from x-ray beams, is active. There are over 650 sensors monitored and networked through the MPS system. About the same number of other process variables are monitored by the much slower EPICS control system, which also has an input to the rf abort chain. The MPS network is still growing with the beam position limits detection system coming on-line. The network configuration, along with a limited description of individual subsystems, is presented.

Fuja, R.; Berg, B.; Arnold, N. [and others

1996-08-01

3

The APS machine protection system (MPS)  

Energy Technology Data Exchange (ETDEWEB)

The machine protection system (MPS) that protects the APS storage ring vacuum chamber from x-ray beams, is active. There are over 650 sensors monitored and networked through the MPS system. About the same number of other process variables are monitored by the much slower EPICS control system, which also has an input to the rf abort chain. The MPS network is still growing with the beam position limits detection system coming on-line. The network configuration, along with a limited description of individual subsystems, is presented. {copyright} {ital 1997 American Institute of Physics.}

Fuja, R.; Berg, W.; Arnold, N.; Decker, G.; Dortwegt, R.; Ferguson, M.; Friedman, N.; Gagliano, J.; Lumpkin, A.; Nawrocki, G.; Wang, X. [Argonne National Laboratory, 9700 South Cass Ave., Argonne, Illinois 60439 (United States of America)

1997-01-01

4

Characteristics of the new MPS II spectrometer system  

Energy Technology Data Exchange (ETDEWEB)

The BNL MPS II is a conversion of the spark chamber detector system of MPS I to a narrow drift space novel drift chamber system. A description is given of this very compact drift chamber system in which the electronics for individual channels is mounted on the chamber. Under actual experimental operating conditions, the chamber shows high resolution of approx. = 200 microns, are dead-time free, and yielded excellent performance. The digital electronics used eliminates channel-by-channel corrections. We have used it in a very large drift chamber system for which it is well suited since it requires less than one integrated circuit per channel. A description of the system, its testing, its use and results obtained in an experiment is presented and discussed.

Etkin, A.; Foley, K.J.; Longacre, R.S.

1982-01-01

5

Characteristics of the new MPS II spectrometer system  

International Nuclear Information System (INIS)

The BNL MPS II is a conversion of the spark chamber detector system of MPS I to a narrow drift space novel drift chamber system. A description is given of this very compact drift chamber system in which the electronics for individual channels is mounted on the chamber. Under actual experimental operating conditions, the chamber shows high resolution of approx. = 200 microns, are dead-time free, and yielded excellent performance. The digital electronics used eliminates channel-by-channel corrections. We have used it in a very large drift chamber system for which it is well suited since it requires less than one integrated circuit per channel. A description of the system, its testing, its use and results obtained in an experiment is presented and discussed

1982-08-08

6

First-in-man (FIM) experience with the Magnetic Medical Positioning System (MPS) for intracoronary navigation.  

UK PubMed Central (United Kingdom)

AIMS: To investigate the safety and feasibility of a newly developed magnetic navigation system for intracoronary tracking. METHODS AND RESULTS: The MediGuide Medical Positioning System (MPS) is a navigation system that was developed to facilitate the navigation of enabled devices within the coronary tree using a magnetic tracking technology. The current prospective, non-randomised, single-centre, first-in-man study was conducted at Universitätsklinikum Regensburg (UKR), Germany on an MPS-enabled AXIOM Artis dFC coronary angiography system (Siemens AG, Forchheim, Germany). We enrolled 20 patients who required IVUS assessment or treatment of a single de novo target lesion in a native coronary artery. The performance was evaluated on a semi-quantitative one-to-five scale where a score of five indicates an excellent superimposition with the vessel and a score of one an unacceptable performance. The mean score for tracking as assessed by projection on life fluoroscopy was 4.89 and 3.58 as assessed by projection on recorded cine-loop. Length measurement of a 20 mm distance was significantly better with the MPS (mean deviation of 0.6 mm=3%) as compared to standard QCA (1.5 mm=8%, p<0.05). Creating a 3D reconstruction was possible in 13 out of 20 cases with an average score of 4.68. No adverse events occurred. CONCLUSIONS: The MediGuide Medical Positioning System is safe and feasible in man, facilitates intracoronary navigation and allows 3D reconstruction of the investigated coronary segment.

Jeron A; Fredersdorf S; Debl K; Oren E; Izmirli A; Peleg A; Nekovar A; Herscovici A; Riegger GA; Luchner A

2009-11-01

7

FEDERAL USERS CONFERENCE PRODUCT LINE TOOL SET (PLTS) MAP PRODUCTION SYSTEM (MPS) ATLAS CUSTOM GRIDS [Rev 0 was draft  

International Nuclear Information System (INIS)

Maps, and more importantly Atlases, are assisting the user community in managing a large land area with complex issues, the most complex of which is the management of nuclear waste. The techniques and experiences discussed herein were gained while developing several atlases for use at the US Department of Energy's Hanford Site. The user community requires the ability to locate not only waste sites, but other features as well. Finding a specific waste site on a map and in the field is a difficult task at a site the size of Hanford. To find a specific waste site, the user begins by locating the item or object in an index, then locating the feature on the corresponding map within an atlas. Locating features requires a method for indexing them. The location index and how to place it on a map or atlas is the central theme presented in this article. The user requirements for atlases forced the design team to develop new and innovative solutions for requirements that Product Line Tool Set (PLTS) Map Production System (MPS)-Atlas was not designed to handle. The layout of the most complex atlases includes custom reference grids, multiple data frames, multiple map series, and up to 250 maps. All of these functional requirements are at the extreme edge of the capabilities of PLTS MPS-Atlas. This document outlines the setup of an atlas using PLTS MPS-Atlas to meet these requirements.

2007-01-09

8

Development of a Lagrangian Meshless Flow Solver based on the Moving Particle Semi-implicit (MPS) Method  

Science.gov (United States)

This paper discusses on the development of a meshless flow solver based on the Lagrangian particle method. The differential operators are discretised by using the particle interaction models proposed in the numerical framework of the Moving Particle Semi-implicit (MPS) technique. The MPS method is attractive from the viewpoint of no mesh is required and fluid is purely represented by points (the virtue of meshless algorithm). Some flow applications attempted by the current meshless solver will be shown and results are compared with the published experimental data.

Ng, K. C.; Ng, Y. L.; Yusoff, M. Z.

2013-06-01

9

Highly concentrated toluene decomposition on the dielectric barrier discharge (DBD) plasma-photocatalytic hybrid system with Mn-Ti-incorporated mesoporous silicate photocatalyst (Mn-Ti-MPS)  

International Nuclear Information System (INIS)

This study investigates the Mn-Ti-incorporated mesoporous silicate (Mn-Ti-MPS) as a photocatalyst for highly concentrated toluene removal in a plasma-photocatalytic hybrid system. Various Mn-Ti-MPS [Ti/Si molar ratio = 1/4, Mn/Ti molar ratio = 0.01/1 (1 mol%), 0.05/1 (5 mol%) and 0.1/1 (10 mol%)] photocatalysts were successfully synthesized using a common hydrothermal method without causing any structural damage. In the X-ray diffraction (XRD) pattern, the main peaks of the TiO2 anatase structure and MnO did not show. All samples displayed hexagonal specific peaks at 2.5 deg. (d100 plane), 4.1 deg. (d110 plane) and 4.7 deg. (d200 plane). This indicates that the Ti ions and Mn ions were well substituted into the Si ion sites in the framework of MCM-41. Their surface areas decreased compared with that of pure MCM-41, while the hexagonal straight pore size was distributed in a range of 2.5-3.5 nm. In the Mn-Ti-MPS, much more water and toluene molecules were absorbed compared to the Ti-MPS. From the X-ray photoelectron spectroscopy (XPS) result, it was determined that the hydrophilicity of the Mn-Ti-MPS was stronger than that of the Ti-MPS. Photocatalytic decomposition for highly concentrated toluene of 1000 ppm increased in the Mn-Ti-MPS when compared with the Ti-MPS, while toluene decomposition on 5 mol% Mn-Ti-MPS was remarkably enhanced to 80% in the plasma system. The conversion to CO2, however, did not improve in the case of the plasma-only system. Nonetheless, in the plasma-photocatalytic hybrid system, the conversion to CO2 for 5 mol% Mn-Ti-MPS reached 43% (in an 800 ppm toluene conversion).

2006-11-15

10

Can operations put the MPS into an unsafe state?  

CERN Document Server

During the 2010 run, the MPS have been additionally stressed by the commissioning of operational procedures and systems tests. As requested by the MPS external review committee, human factors have to be further minimized and discipline reinforced when increasing the stored beam energies towards and beyond the 2010 target of 30 MJ. This talk will present a synthesis of the Evian discussion on MPS and human factors, with an emphasis on the tools and procedures to be put in place for the 2011 run in order to ensure the machine safety during standard beam operation and after periods of machine developments or technical stops.

Ponce, L

2011-01-01

11

CP/MPS - contained plasma magnetic propulsion system: An advanced propulsion concept  

Energy Technology Data Exchange (ETDEWEB)

A new concept for an electric propulsion system is presented which combines small physical size with high current densities to produce usable propulsion for satellite docking, remote manipulation of satellites and sensitive payloads, station keeping, space tug or orbital transfer (OTV) and for a transatmospheric vehicle (TAV) which is gyro-stabilized. The design has evolved over the past five years to its present state. The concept is described and placed into perspective with state of the art MPD and electric propulsion devices. 14 references.

Mccanney, J.M.

1987-01-01

12

Effects of the Selective MPS1 Inhibitor MPS1-IN-3 on Glioblastoma Sensitivity to Antimitotic Drugs.  

UK PubMed Central (United Kingdom)

BACKGROUND: Glioblastomas exhibit a high level of chemotherapeutic resistance, including to the antimitotic agents vincristine and taxol. During the mitotic agent-induced arrest, glioblastoma cells are able to perform damage-control and self-repair to continue proliferation. Monopolar spindle 1 (MPS1/TTK) is a checkpoint kinase and a gatekeeper of the mitotic arrest. METHODS: We used glioblastoma cells to determine the expression of MPS1 and to determine the effects of MPS1 inhibition on mitotic errors and cell viability in combination with vincristine and taxol. The effect of MPS1 inhibition was assessed in different orthotopic glioblastoma mouse models (n = 3-7 mice/group). MPS1 expression levels were examined in relation to patient survival. RESULTS: Using publicly available gene expression data, we determined that MPS1 overexpression corresponds positively with tumor grade and negatively with patient survival (two-sided t test, P < .001). Patients with high MPS1 expression (n = 203) had a median and mean survival of 487 and 913 days (95% confidence intervals [CI] = 751 to 1075), respectively, and a 2-year survival rate of 35%, whereas patients with intermediate MPS1 expression (n = 140) had a median and mean survival of 858 and 1183 days (95% CI = 1177 to 1189), respectively, and a 2-year survival rate of 56%. We demonstrate that MPS1 inhibition by RNAi results in sensitization to antimitotic agents. We developed a selective small-molecule inhibitor of MPS1, MPS1-IN-3, which caused mitotic aberrancies in glioblastoma cells and, in combination with vincristine, induced mitotic checkpoint override, increased aneuploidy, and augmented cell death. MPS1-IN-3 sensitizes glioblastoma cells to vincristine in orthotopic mouse models (two-sided log-rank test, P < .01), resulting in prolonged survival without toxicity. CONCLUSIONS: Our results collectively demonstrate that MPS1, a putative therapeutic target in glioblastoma, can be selectively inhibited by MPS1-IN-3 sensitizing glioblastoma cells to antimitotic drugs.

Tannous BA; Kerami M; Van der Stoop PM; Kwiatkowski N; Wang J; Zhou W; Kessler AF; Lewandrowski G; Hiddingh L; Sol N; Lagerweij T; Wedekind L; Niers JM; Barazas M; Nilsson RJ; Geerts D; De Witt Hamer PC; Hagemann C; Vandertop WP; Van Tellingen O; Noske DP; Gray NS; Würdinger T

2013-08-01

13

Effects of the selective MPS1 inhibitor MPS1-IN-3 on glioblastoma sensitivity to antimitotic drugs.  

UK PubMed Central (United Kingdom)

BACKGROUND: Glioblastomas exhibit a high level of chemotherapeutic resistance, including to the antimitotic agents vincristine and taxol. During the mitotic agent-induced arrest, glioblastoma cells are able to perform damage-control and self-repair to continue proliferation. Monopolar spindle 1 (MPS1/TTK) is a checkpoint kinase and a gatekeeper of the mitotic arrest. METHODS: We used glioblastoma cells to determine the expression of MPS1 and to determine the effects of MPS1 inhibition on mitotic errors and cell viability in combination with vincristine and taxol. The effect of MPS1 inhibition was assessed in different orthotopic glioblastoma mouse models (n = 3-7 mice/group). MPS1 expression levels were examined in relation to patient survival. RESULTS: Using publicly available gene expression data, we determined that MPS1 overexpression corresponds positively with tumor grade and negatively with patient survival (two-sided t test, P < .001). Patients with high MPS1 expression (n = 203) had a median and mean survival of 487 and 913 days (95% confidence intervals [CI] = 751 to 1075), respectively, and a 2-year survival rate of 35%, whereas patients with intermediate MPS1 expression (n = 140) had a median and mean survival of 858 and 1183 days (95% CI = 1177 to 1189), respectively, and a 2-year survival rate of 56%. We demonstrate that MPS1 inhibition by RNAi results in sensitization to antimitotic agents. We developed a selective small-molecule inhibitor of MPS1, MPS1-IN-3, which caused mitotic aberrancies in glioblastoma cells and, in combination with vincristine, induced mitotic checkpoint override, increased aneuploidy, and augmented cell death. MPS1-IN-3 sensitizes glioblastoma cells to vincristine in orthotopic mouse models (two-sided log-rank test, P < .01), resulting in prolonged survival without toxicity. CONCLUSIONS: Our results collectively demonstrate that MPS1, a putative therapeutic target in glioblastoma, can be selectively inhibited by MPS1-IN-3 sensitizing glioblastoma cells to antimitotic drugs.

Tannous BA; Kerami M; Van der Stoop PM; Kwiatkowski N; Wang J; Zhou W; Kessler AF; Lewandrowski G; Hiddingh L; Sol N; Lagerweij T; Wedekind L; Niers JM; Barazas M; Nilsson RJ; Geerts D; De Witt Hamer PC; Hagemann C; Vandertop WP; Van Tellingen O; Noske DP; Gray NS; Würdinger T

2013-09-01

14

On the consistency of MPS  

CERN Document Server

The consistency of Moving Particle Semi-implicit (MPS) method in reproducing the gradient, divergence and Laplacian differential operators is discussed in the present paper. Its relation to the Smoothed Particle Hydrodynamics (SPH) method is rigorously established. The application of the MPS method to solve the Navier-Stokes equations using a fractional step approach is treated, unveiling inconsistency problems when solving the Poisson equation for the pressure. A new corrected MPS method incorporating boundary terms is proposed. Applications to one dimensional boundary value Dirichlet and mixed Neumann-Dirichlet problems and to two-dimensional free-surface flows are presented.

Souto-Iglesias, Antonio; González, Leo M; Cercos-Pita, Jose L

2013-01-01

15

On the consistency of MPS  

Science.gov (United States)

The consistency of the Moving Particle Semi-implicit (MPS) method in reproducing the gradient, divergence and Laplacian differential operators is discussed in the present paper. Its relation to the Smoothed Particle Hydrodynamics (SPH) method is rigorously established. The application of the MPS method to solve the Navier-Stokes equations using a fractional step approach is treated, unveiling inconsistency problems when solving the Poisson equation for the pressure. A new corrected MPS method incorporating boundary terms is proposed. Applications to one dimensional boundary value Dirichlet and mixed Neumann-Dirichlet problems and to two-dimensional free-surface flows are presented.

Souto-Iglesias, Antonio; Macià, Fabricio; González, Leo M.; Cercos-Pita, Jose L.

2013-03-01

16

Most predictable surface (MPS) mapping method in petroleum exploration  

Energy Technology Data Exchange (ETDEWEB)

This paper introduces a numerical procedure for displaying facies configuration and the rate of facies change. The procedure is termed the Most Predictable Surface (MPS) mapping method. The Beaverhill Lake Group and Nisku Formation of the Western Canada Basin were analyzed as examples to demonstrate the use of MPS mapping in subsurface facies analysis. The facies variants of the Beaverhill Lake Group suggest anomalies that would have helped explorationists pinpoint areas for intensive geophysical surveys. The paleotopography of the Nisku Formation outlines areas favorable for the developments of fore-, barrier, or patch reefs. The MPS method could, therefore, have led to geological and geophysical exploration in the areas of interest.

Lee, P.J.

1981-06-01

17

MPS beam control software architecture  

International Nuclear Information System (INIS)

The new Machine Protection System (MPS) now being tested at SLAC has a beam control subsystem resident in processors located close to the beam monitoring devices within the machine. There are two types of beam control micros: Algorithm Processors (AP's) which collect and evaluate data from monitoring devices, and a Supervisor (SUPE) which collects and evaluates data from all the AP's. The SUPE also receives the global machine beamcode indicating beam presence, and passes it on to the AP's. The SUPE receives the beamcode pattern from the Master Pattern Generator (MPG) via a shared-memory communication link. MIL-1553 serial communication is used between the SUPE and the AP's, and between the AP's and the monitoring devices. Multitasking software is used to allow high priority handling of data evaluation and low priority handling of host/user interfacing and event reporting. Pipelining of data between acquisition and evaluation and reporting is used to accomodate the processing capacity, while still supporting full processing at the 360Hz broadcast rate of the beamcode pattern

1993-01-01

18

Microcontroller Programming and Interfacing TI MPS433  

CERN Multimedia

This book provides a thorough introduction to the Texas Instruments MPS430 microcontroller. The MPS430 is a 16-bit reduced instruction set (RISC) processor that features ultra low power consumption and integrated digital and analog hardware. Variants of the MPS430 microcontroller have been in production since 1993. This provides for a host of MPS430 products including evaluation boards, compilers, and documentation. A thorough introduction to the MPS430 line of microcontrollers, programming techniques, and interface concepts are provided along with considerable tutorial information with many i

Barrett, Steven

2011-01-01

19

Benchmarking MPS for fractional quantum Hall states  

Science.gov (United States)

We discuss the numerical apsects of the Matrix Product State (MPS) representation for a large series of Fractional Quantum Hall states. We benchmark the MPS for several model states such as the Read-Rezayi series using both overlap, energies, densities and pair correlation functions. We discuss how accurate this description is depending on the geometry (sphere, disk or cylinder). As an application, we use the MPS to compute the size of the quasiholes for the Read-Rezayi series.

Regnault, Nicolas; Estienne, Benoit; Papic, Zlatko; Bernevig, B. Andrei

2013-03-01

20

Addendum to "On the consistency of MPS"  

CERN Document Server

The analogies between the Moving Particle Semi-implicit method (MPS) and Incompressible Smoothed Particle Hydrodynamics method (ISPH) are established in this note, as an extension of the MPS consistency analysis conducted in "Souto-Iglesias et al., Computer Physics Communications, 184(3), 2013."

Souto-Iglesias, Antonio; González, Leo M; Cercos-Pita, Jose L

2013-01-01

 
 
 
 
21

MPS Vax monitor and control software architecture  

International Nuclear Information System (INIS)

The new Machine Protection System (MPS) now being tested at the SLAC Linear Collider (SLC) includes monitoring and controlling facilities integrated into the existing VAX control system. The actual machine protection is performed by VME micros which control the beam repetition rate on a pulse-by-pulse basis based on measurements from fault detectors. The VAX is used to control and configure the VME micros, configure custom CAMAC modules providing the fault detector inputs, monitor and report faults and system errors, update the SLC database, and interface with the user. The design goals of the VAX software include a database-driven system to allow configuration changes without code changes, use of a standard TCP/IP-based message service for communication, use of existing SLCNET micros for CAMAC configuration, security and verification features to prevent unauthorized access, error and alarm logging and display updates as quickly as possible, and use of touch panels and X-windows displays for the user interface

1993-01-01

22

MPS Vax monitor and control software architecture  

Energy Technology Data Exchange (ETDEWEB)

The new Machine Protection System (MPS) now being tested at the SLAC Linear Collider (SLC) includes monitoring and controlling facilities integrated into the existing VAX control system. The actual machine protection is performed by VME micros which control the beam repetition rate on a pulse-by-pulse basis based on measurements from fault detectors. The VAX is used to control and configure the VME micros, configure custom CAMAC modules providing the fault detector inputs, monitor and report faults and system errors, update the SLC database, and interface with the user. The design goals of the VAX software include a database-driven system to allow configuration changes without code changes, use of a standard TCP/IP-based message service for communication, use of existing SLCNET micros for CAMAC configuration, security and verification features to prevent unauthorized access, error and alarm logging and display updates as quickly as possible, and use of touch panels and X-windows displays for the user interface.

Allison, S.; Spencer, N.; Underwood, K.; VanOlst, D.; Zelanzy, M.

1993-04-01

23

Sociological profiles of Mersin MP’s  

Directory of Open Access Journals (Sweden)

Full Text Available This study was designed to find general characteristics of Mersin MP’s in Multi Party Period (Since 1950 up to Date). On the final stage the place of Mersin MP’s in Turkish political elites will be examined. Social background peculiarities (gender, age, education, occupation, family size) were used to achieve the objectives. Documentary and historical research techniques were applied in the paper. An original data set was produced for analysis from the official publications and records and publications of the Turkish Grand National Assembly which is the main legislative organ in Turkey. The data set was analysed by using SPSS (Statistical Package for the Social Sciences).As a result of examining all the assemblies in the Multi Party period these major findings were discovered in related with Mersin MP’s: A large majority of Mersin MP’s were well educated, male, married, with a small family size and middle aged. Moreover the large majority of Mersin MP’s were lawyers and civil bureaucrats. Although the situation has begun to change in recent years, the deputies have exhibited an elitist character as compared with the general population of Mersin.

D. Ali Arslan

2012-01-01

24

Development of d.c. power supply for gyrotron with energy recovery system  

International Nuclear Information System (INIS)

A new type of power supply system for a gyrotron with collector potential depression (CPD) to enhance gyrotron efficiency was developed. The power supply system is composed of a main power supply (MPS) and an acceleration power supply (APS). The APS which provides the stable high field to the magnetron injection gun (MIG) of the gyrotron is the key point of the system. The DC-DC converter technique is applied to the APS and it can output 100 kV of maximum voltage within ±0.5% stability and 300 mA of maximum current. The CPD gyrotron operation was successfully achieved with an efficiency of 48% and power of 350 kW for 5 s at 110 GHz. The stable gyrotron operation, without regulation of MPS, which provides the d.c. input power to the gyrotron, has been demonstrated by the combination of the APS and MPS. (orig.).

1997-01-01

25

Improvement in behaviour after substrate deprivation therapy with rhodamine B in a mouse model of MPS IIIA.  

Science.gov (United States)

Mucopolysaccharidosis type IIIA (MPS IIIA) is a specific lysosomal storage disorder caused by an enzyme deficiency in sulphamidase, which is required for the degradation of heparan sulphate glycosaminoglycan (gag). This deficiency results in widespread gag storage and leads to severe CNS degeneration and mild somatic pathology. We have developed substrate deprivation as a therapy (SDT) for MPS disorders to reduce the initial production of gag substrate for the deficient enzyme, using the compound rhodamine B as an inhibitor of gag biosynthesis. This should restore the balance between gag level and residual enzyme activity towards normal and improve patient outcome. To determine if SDT improved CNS function, MPS IIIA mice were treated for 6months with weekly, intravenous 1mg/kg rhodamine B and then tested in a 4-arm water cross maze, which measures spatial learning and memory. MPS IIIA untreated mice were unable to perform to the same level as normal littermates, having increased escape latency, increased incorrect entries and decreased correct entries. Rhodamine B treatment improved MPS IIIA performance towards normal with treated mice having decreased escape latency, decreased incorrect entries and increased correct entries when compared to MPS IIIA untreated littermates. This provides the first report of SDT resulting in a beneficial effect on CNS function in an MPS disorder and SDT targeting gag synthesis may be a viable treatment option for children with MPS. PMID:17681480

Roberts, Ainslie L K; Rees, Matthew H; Klebe, Sonja; Fletcher, Janice M; Byers, Sharon

2007-08-06

26

Improvement in behaviour after substrate deprivation therapy with rhodamine B in a mouse model of MPS IIIA.  

UK PubMed Central (United Kingdom)

Mucopolysaccharidosis type IIIA (MPS IIIA) is a specific lysosomal storage disorder caused by an enzyme deficiency in sulphamidase, which is required for the degradation of heparan sulphate glycosaminoglycan (gag). This deficiency results in widespread gag storage and leads to severe CNS degeneration and mild somatic pathology. We have developed substrate deprivation as a therapy (SDT) for MPS disorders to reduce the initial production of gag substrate for the deficient enzyme, using the compound rhodamine B as an inhibitor of gag biosynthesis. This should restore the balance between gag level and residual enzyme activity towards normal and improve patient outcome. To determine if SDT improved CNS function, MPS IIIA mice were treated for 6months with weekly, intravenous 1mg/kg rhodamine B and then tested in a 4-arm water cross maze, which measures spatial learning and memory. MPS IIIA untreated mice were unable to perform to the same level as normal littermates, having increased escape latency, increased incorrect entries and decreased correct entries. Rhodamine B treatment improved MPS IIIA performance towards normal with treated mice having decreased escape latency, decreased incorrect entries and increased correct entries when compared to MPS IIIA untreated littermates. This provides the first report of SDT resulting in a beneficial effect on CNS function in an MPS disorder and SDT targeting gag synthesis may be a viable treatment option for children with MPS.

Roberts AL; Rees MH; Klebe S; Fletcher JM; Byers S

2007-09-01

27

BNL multiparticle spectrometer (MPS) program  

International Nuclear Information System (INIS)

[en] The design and operation of the BNL multiparticle spectrometer are described. Also a formation experiment anti pp ? n/sub c/ ? final state was studied at 3.7 to 4.2 GeV/c tuning the total cm energy of the anti pp system to lie near the just below the J mass to search for the existence of a narrow peak (J/sup PC/ = O/sup -+ /GAMMA? several MeV). No outstanding peak is seen, but an approximate cross section limit is given in the region of a few microbarns. There is a clear K0 signal. Also a plot of the effective mass and missing mass for events with two neutral K's produced by 8.7-GeV/c ?- on hydrogen is given

1975-07-07

28

Capturing phenotypic heterogeneity in MPS I: results of an international consensus procedure  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Mucopolysaccharidosis type I (MPS I) is traditionally divided into three phenotypes: the severe Hurler (MPS I-H) phenotype, the intermediate Hurler-Scheie (MPS I-H/S) phenotype and the attenuated Scheie (MPS I-S) phenotype. However, there are no clear criteria for delineating the different phenotypes. Because decisions about optimal treatment (enzyme replacement therapy or hematopoietic stem cell transplantation) need to be made quickly and depend on the presumed phenotype, an assessment of phenotypic severity should be performed soon after diagnosis. Therefore, a numerical severity scale for classifying different MPS I phenotypes at diagnosis based on clinical signs and symptoms was developed. Methods A consensus procedure based on a combined modified Delphi method and a nominal group technique was undertaken. It consisted of two written rounds and a face-to-face meeting. Sixteen MPS I experts participated in the process. The main goal was to identify the most important indicators of phenotypic severity and include these in a numerical severity scale. The correlation between the median subjective expert MPS I rating and the scores derived from this severity scale was used as an indicator of validity. Results Full consensus was reached on six key clinical items for assessing severity: age of onset of signs and symptoms, developmental delay, joint stiffness/arthropathy/contractures, kyphosis, cardiomyopathy and large head/frontal bossing. Due to the remarkably large variability in the expert MPS I assessments, however, a reliable numerical scale could not be constructed. Because of this variability, such a scale would always result in patients whose calculated severity score differed unacceptably from the median expert severity score, which was considered to be the 'gold standard'. Conclusions Although consensus was reached on the six key items for assessing phenotypic severity in MPS I, expert opinion on phenotypic severity at diagnosis proved to be highly variable. This subjectivity emphasizes the need for validated biomarkers and improved genotype-phenotype correlations that can be incorporated into phenotypic severity assessments at diagnosis.

de Ru Minke H; Teunissen Quirine GA; van der Lee Johanna H; Beck Michael; Bodamer Olaf A; Clarke Lorne A; Hollak Carla E; Lin Shuan-Pei; Rojas Maria-Verónica; Pastores Gregory M; Raiman Julian A; Scarpa Maurizio; Treacy Eileen P; Tylki-Szymanska Anna; Wraith J Edmond; Zeman Jiri; Wijburg Frits A

2012-01-01

29

Email and political campaigning: the experience of MPs in Westminster  

Directory of Open Access Journals (Sweden)

Full Text Available Traditionally individual politicians communicated directly with their constituents, but the arrival of the mass media, especially television, eroded the role of direct communication. The development of new Information Communication Technologies (ICTs) is now re-opening the use of direct communication as part of post-modern campaigning (Norris 2000), with the Internet providing an alternative to media relations. The World Wide Web has attracted great interest from political commentators, but so far email has been largely ignored. Yet the Web is a pull technique, whereas the push nature of email opens up new campaigning possibilities. Downes and Mui (2000) suggest that email represents potentially a 'killer app' which might revolutionize the way MPs approach re-election. A survey of Members of Parliament (MPs) Assembly Members (AMs) of the Welsh Assembly and Members of the Scottish Parliament (MSPs) examines whether they have grasped the opportunities email represents. The research suggests that the outbound use of email for campaigning purposes is limited to a small number of pioneers. Resources, parliamentary culture and party affiliation all shape the use of email campaigning.

Nigel Jackson

2004-01-01

30

The viStaMPS tool for visualization and manipulation of time series interferometric results  

Science.gov (United States)

In the last decade, Synthetic Aperture Radar Interferometry (InSAR) has become operational as a technique that allows remote detection of deformation at the Earth's surface. Analysis of time series of SAR images extends the area where InSAR can be successfully applied and also permits detection of smaller displacements through the reduction of error sources. Stanford Method for Persistent Scatterers (StaMPS) InSAR implementation, which is based on the processing of multi-temporal SAR data, is widely used for ground deformation monitoring. This is due mainly to its proven reliability and freeware distribution among the scientific community. However, some issues can make the interpretation of the results a difficult task: StaMPS supports data processing based on command prompt, which increases the difficulty of usage by users not familiar with the specific programming language that supports StaMPS. Moreover, several visualization tasks are not implemented in the standard approach requiring that each user develop its own code for visualization and interpretation purposes. In this paper, we present viStaMPS, a new visual application developed to enhance the visualization, manipulation and exportation of StaMPS results. The programmed application is developed in Matlab through the Graphical User Interface (GUI) and no coding is required for running it, which avoids any programming language knowledge for standard uses. The included graphical interface is very versatile allowing the user to choose among several features: visualization, manipulation and exportation of data which are not available in the original StaMPS.

Sousa, Joaquim J.; Magalhães, Luis G.; Ruiz, Antonio M.; Sousa, António M. R.; Cardoso, Gil

2013-03-01

31

Numerical analysis of fuel-coolant interactions in coolant injection mode using MPS  

Energy Technology Data Exchange (ETDEWEB)

The numerical method used in this study is the Moving Particle Semi-implicit (MPS) method which is based on moving particles and their interactions. Grids are not necessary, so that large fluid deformation can be calculated without numerical diffusion. Boiling and solidification models are developed for the MPS method. Melt injection is calculated considering boiling and solidification. Clusters of melt particles appear due to solidification. To understand the fundamental physics of the jet penetration, water jet injection into a pool of a denser fluid under non-boiling and isothermal conditions are calculated using the MPS method. The density ratio of the denser fluid to water is 1.88 (fluorinert) or 9.4 (anatomical alloy). The calculation results are compared with experiments, which were conducted in the ALPHA/MUSE facility at JAERI. In the calculation, air entrainment is observed as the experiments due to the jet penetration. However, the maximum jet penetration depth is shallower than the experiments. (author)

Ikeda, Hirokazu; Koshizuka, Seiichi; Oka, Yoshiaki [Nuclear Engineering Research Laboratory, The University of Tokyo, Tokyo (Japan); Park, Hyun-sun; Sugimoto, Jun

1999-07-01

32

Deployment Area Selection and Land Withdrawal/Acquisition. M-X/MPS (M-X/Multiple Protective Shelter) Environmental Technical Report. Public Finance Model.  

Science.gov (United States)

On October 2, 1981, the President announced his decision cancel the M-X Multiple Protective Shelter (MPS) basing system. The Air Force was, at that time, working to prepare a Final Environmental Impact Statement (FEIS) for the MPS site selection process. ...

1981-01-01

33

Initial experience with myocardial perfusion scintigraphy (MPS) in patients awaiting lung volume reduction surgery (LVRS)  

International Nuclear Information System (INIS)

Full text: LVRS is an effective therapeutic option for patients with end-stage chronic airway limitation (CAL). Pre-operative cardiac assessment in such patients is vital for a favourable outcome. We reviewed the role of MPS in the pre-operative cardiac risk stratification of patients undergoing LVRS. Of 37 patients who underwent LVRS, 25 patients (11M/14F; mean age 59.9 yrs) were evaluated pre-operatively with a MPS. Two had a history of ischaemic heart disease. 17 patients were given dipyridamole (IV - 0.05mg/kg), and eight patients were given dobutamine (IV). The LVEF was determined in 11/25 patients (range - 54-79%, mean 65.5%). Reversible defects were reported in two patients; one involving the antero-lateral wall, confirmed with coronary catheterisation (C/C) (100% LAD lesion) and treated successfully with angioplasty, and 1 involving the inferior wall (false positive on C/C). Two fixed defects were reported, each involving the inferior wall and consistent with a history of prior inferior wall myocardial infarction. The post-operative course was favourable in all patients who had a MPS, except in one who died from sepsis, while another developed mild biventricular failure three months post-operatively. Both these patients had a normal MPS. In those who did not have a MPS study, 2/12 patients died in the post-operative period; one from sepsis (normal C/C), and the other from biventricular failure. No other cardiac complications were documented. Although the population size was small, MPS assisted in the pre-operative cardiac risk stratification and management of patients undergoing LVRS. Copyright (2000) The Australian and New Zealand Society of Nuclear Medicine Inc

2000-01-01

34

Intracerebroventricular transplantation of human bone marrow-derived multipotent progenitor cells in an immunodeficient mouse model of mucopolysaccharidosis type I (MPS-I).  

Science.gov (United States)

Mucopolysaccharidosis type I (MPS-I; Hurler syndrome) is an inborn error of metabolism caused by lack of the functional lysosomal glycosaminoglycan (GAG)-degrading enzyme ?-L-iduronidase (IDUA). Without treatment, the resulting GAG accumulation causes multisystem dysfunction and death within the first decade. Current treatments include allogeneic hematopoietic stem cell transplantation (HSCT) and enzyme replacement therapy. HSCT ameliorates clinical features and extends life but is not available to all patients, and inadequately corrects the most devastating features of the disease including mental retardation and skeletal deformities. Recent developments suggest that stem cells can be used to deliver needed enzymes to the central nervous system. To test this concept, we transplanted bone marrow-derived normal adult human MultiStem® cells into the cerebral lateral ventricles of immunodeficient MPS-I neonatal mice. Transplanted cells and human-specific DNA were detected in the hippocampal formation, striatum, and other areas of the central nervous system. Brain tissue assays revealed significant long-term decrease in GAG levels in the hippocampus and striatum. Sensorimotor testing 6 months after transplantation demonstrated significantly improved rotarod performance of transplanted mice in comparison to nontransplanted and sham-transplanted control animals. These results suggest that a single injection of MultiStem cells into the cerebral ventricles of neonatal MPS-I mice induces sustained reduction in GAG accumulation within the brain, and modest long-term improvement in sensorimotor function. PMID:22472595

Nan, Zhenhong; Shekels, Laurie; Ryabinin, Oleg; Evavold, Carrie; Nelson, Matthew S; Khan, Shaukat A; Deans, Robert J; Mays, Robert W; Low, Walter C; Gupta, Pankaj

2012-01-01

35

Intracerebroventricular transplantation of human bone marrow-derived multipotent progenitor cells in an immunodeficient mouse model of mucopolysaccharidosis type I (MPS-I).  

UK PubMed Central (United Kingdom)

Mucopolysaccharidosis type I (MPS-I; Hurler syndrome) is an inborn error of metabolism caused by lack of the functional lysosomal glycosaminoglycan (GAG)-degrading enzyme ?-L-iduronidase (IDUA). Without treatment, the resulting GAG accumulation causes multisystem dysfunction and death within the first decade. Current treatments include allogeneic hematopoietic stem cell transplantation (HSCT) and enzyme replacement therapy. HSCT ameliorates clinical features and extends life but is not available to all patients, and inadequately corrects the most devastating features of the disease including mental retardation and skeletal deformities. Recent developments suggest that stem cells can be used to deliver needed enzymes to the central nervous system. To test this concept, we transplanted bone marrow-derived normal adult human MultiStem® cells into the cerebral lateral ventricles of immunodeficient MPS-I neonatal mice. Transplanted cells and human-specific DNA were detected in the hippocampal formation, striatum, and other areas of the central nervous system. Brain tissue assays revealed significant long-term decrease in GAG levels in the hippocampus and striatum. Sensorimotor testing 6 months after transplantation demonstrated significantly improved rotarod performance of transplanted mice in comparison to nontransplanted and sham-transplanted control animals. These results suggest that a single injection of MultiStem cells into the cerebral ventricles of neonatal MPS-I mice induces sustained reduction in GAG accumulation within the brain, and modest long-term improvement in sensorimotor function.

Nan Z; Shekels L; Ryabinin O; Evavold C; Nelson MS; Khan SA; Deans RJ; Mays RW; Low WC; Gupta P

2012-01-01

36

Characterization of novel MPS1 inhibitors with preclinical anticancer activity.  

UK PubMed Central (United Kingdom)

Monopolar spindle 1 (MPS1), a mitotic kinase that is overexpressed in several human cancers, contributes to the alignment of chromosomes to the metaphase plate as well as to the execution of the spindle assembly checkpoint (SAC). Here, we report the identification and functional characterization of three novel inhibitors of MPS1 of two independent structural classes, N-(4-{2-[(2-cyanophenyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}phenyl)-2-phenylacetamide (Mps-BAY1) (a triazolopyridine), N-cyclopropyl-4-{8-[(2-methylpropyl)amino]-6-(quinolin-5-yl)imidazo[1,2-a]pyrazin-3-yl}benzamide (Mps-BAY2a) and N-cyclopropyl-4-{8-(isobutylamino)imidazo[1,2-a]pyrazin-3-yl}benzamide (Mps-BAY2b) (two imidazopyrazines). By selectively inactivating MPS1, these small inhibitors can arrest the proliferation of cancer cells, causing their polyploidization and/or their demise. Cancer cells treated with Mps-BAY1 or Mps-BAY2a manifested multiple signs of mitotic perturbation including inefficient chromosomal congression during metaphase, unscheduled SAC inactivation and severe anaphase defects. Videomicroscopic cell fate profiling of histone 2B-green fluorescent protein-expressing cells revealed the capacity of MPS1 inhibitors to subvert the correct timing of mitosis as they induce a premature anaphase entry in the context of misaligned metaphase plates. Hence, in the presence of MPS1 inhibitors, cells either divided in a bipolar (but often asymmetric) manner or entered one or more rounds of abortive mitoses, generating gross aneuploidy and polyploidy, respectively. In both cases, cells ultimately succumbed to the mitotic catastrophe-induced activation of the mitochondrial pathway of apoptosis. Of note, low doses of MPS1 inhibitors and paclitaxel (a microtubular poison) synergized at increasing the frequency of chromosome misalignments and missegregations in the context of SAC inactivation. This resulted in massive polyploidization followed by the activation of mitotic catastrophe. A synergistic interaction between paclitaxel and MPS1 inhibitors could also be demonstrated in vivo, as the combination of these agents efficiently reduced the growth of tumor xenografts and exerted superior antineoplastic effects compared with either compound employed alone. Altogether, these results suggest that MPS1 inhibitors may exert robust anticancer activity, either as standalone therapeutic interventions or combined with microtubule-targeting chemicals.Cell Death and Differentiation advance online publication, 9 August 2013; doi:10.1038/cdd.2013.105.

Jemaà M; Galluzzi L; Kepp O; Senovilla L; Brands M; Boemer U; Koppitz M; Lienau P; Prechtl S; Schulze V; Siemeister G; Wengner AM; Mumberg D; Ziegelbauer K; Abrieu A; Castedo M; Vitale I; Kroemer G

2013-08-01

37

Characterization of spindle checkpoint kinase Mps1 reveals domain with functional and structural similarities to tetratricopeptide repeat motifs of Bub1 and BubR1 checkpoint kinases.  

UK PubMed Central (United Kingdom)

Kinetochore targeting of the mitotic kinases Bub1, BubR1, and Mps1 has been implicated in efficient execution of their functions in the spindle checkpoint, the self-monitoring system of the eukaryotic cell cycle that ensures chromosome segregation occurs with high fidelity. In all three kinases, kinetochore docking is mediated by the N-terminal region of the protein. Deletions within this region result in checkpoint failure and chromosome segregation defects. Here, we use an interdisciplinary approach that includes biophysical, biochemical, cell biological, and bioinformatics methods to study the N-terminal region of human Mps1. We report the identification of a tandem repeat of the tetratricopeptide repeat (TPR) motif in the N-terminal kinetochore binding region of Mps1, with close homology to the tandem TPR motif of Bub1 and BubR1. Phylogenetic analysis indicates that TPR Mps1 was acquired after the split between deutorostomes and protostomes, as it is distinguishable in chordates and echinoderms. Overexpression of TPR Mps1 resulted in decreased efficiency of both chromosome alignment and mitotic arrest, likely through displacement of endogenous Mps1 from the kinetochore and decreased Mps1 catalytic activity. Taken together, our multidisciplinary strategy provides new insights into the evolution, structural organization, and function of Mps1 N-terminal region.

Lee S; Thebault P; Freschi L; Beaufils S; Blundell TL; Landry CR; Bolanos-Garcia VM; Elowe S

2012-02-01

38

Enzyme replacement therapy with galsulfase in 34 children younger than five years of age with MPS VI.  

UK PubMed Central (United Kingdom)

BACKGROUND: Mucopolysaccharidosis type VI (MPS VI) is a progressive, chronic and multisystem lysosomal storage disease with a wide disease spectrum. Clinical and biochemical improvements have been reported for MPS VI patients on enzyme replacement therapy (ERT) with rhASB (recombinant human arylsulfatase B; galsulfase, Naglazyme®, BioMarin Pharmaceutical Inc.), making early diagnosis and intervention imperative for optimal patient outcomes. Few studies have included children younger than five years of age. This report describes 34 MPS VI patients that started treatment with galsulfase before five years of age. METHODS: Data from patients who initiated treatment at <5 years of age were collected from patients' medical records. Baseline and follow-up assessments of common symptoms that led to diagnosis and that were used to evaluate disease progression and treatment efficacy were evaluated. RESULTS: A significant negative correlation was seen with treatment with ERT and urinary GAG levels. Of those with baseline and follow-up growth data, 47% remained on their pre-treatment growth curve or moved to a higher percentile after treatment. Of the 9 patients with baseline and follow-up sleep studies, 5 remained unaffected and 1 patient initially with mild sleep apnea showed improvement. Data regarding cardiac, ophthalmic, central nervous system, hearing, surgical interventions and development are also reported. No patient discontinued treatment due to an adverse event and all that were treatment-emergent resolved. CONCLUSIONS: The prescribed dosage of 1mg/kg IV weekly with galsulfase ERT is shown to be safe and effective in slowing and/or improving certain aspects of the disease, although patients should be closely monitored for complications associated with the natural history of the disease, especially cardiac valve involvement and spinal cord compression. A long-term follow-up investigation of this group of children will provide further information on the benefits of early treatment as well as disease progression and treatment efficacy and safety in this young patient population.

Horovitz DD; Magalhães TS; Acosta A; Ribeiro EM; Giuliani LR; Palhares DB; Kim CA; de Paula AC; Kerstenestzy M; Pianovski MA; Costa MI; Santos FC; Martins AM; Aranda CS; Correa Neto J; Holanda GB; Cardoso L Jr; da Silva CA; Bonatti RC; Ribeiro BF; Rodrigues Mdo C; Llerena JC Jr

2013-05-01

39

Indazole-based potent and cell-active Mps1 kinase inhibitors: rational design from pan-kinase inhibitor anthrapyrazolone (SP600125).  

Science.gov (United States)

Monopolar spindle 1 (Mps1) is essential for centrosome duplication, the spindle assembly check point, and the maintenance of chromosomal instability. Mps1 is highly expressed in cancer cells, and its expression levels correlate with the histological grades of cancers. Thus, selective Mps1 inhibitors offer an attractive opportunity for the development of novel cancer therapies. To design novel Mps1 inhibitors, we utilized the pan-kinase inhibitor anthrapyrazolone (4, SP600125) and its crystal structure bound to JNK1. Our design efforts led to the identification of indazole-based lead 6 with an Mps1 IC50 value of 498 nM. Optimization of the 3- and 6-positions on the indazole core of 6 resulted in 23c with improved Mps1 activity (IC50 = 3.06 nM). Finally, application of structure-based design using the X-ray structure of 23d bound to Mps1 culminated in the discovery of 32a and 32b with improved potency for cellular Mps1 and A549 lung cancer cells. Moreover, 32a and 32b exhibited reasonable selectivities over 120 and 166 kinases, respectively. PMID:23634759

Kusakabe, Ken-ichi; Ide, Nobuyuki; Daigo, Yataro; Tachibana, Yuki; Itoh, Takeshi; Yamamoto, Takahiko; Hashizume, Hiroshi; Hato, Yoshio; Higashino, Kenichi; Okano, Yousuke; Sato, Yuji; Inoue, Makiko; Iguchi, Motofumi; Kanazawa, Takayuki; Ishioka, Yukichi; Dohi, Keiji; Kido, Yasuto; Sakamoto, Shingo; Yasuo, Kazuya; Maeda, Masahiro; Higaki, Masayo; Ueda, Kazuo; Yoshizawa, Hidenori; Baba, Yoshiyasu; Shiota, Takeshi; Murai, Hitoshi; Nakamura, Yusuke

2013-05-24

40

Neonatal Bone Marrow Transplantation in MPS IIIA Mice.  

UK PubMed Central (United Kingdom)

Patients with some neurological lysosomal storage disorders (LSD) exhibit improved clinical signs following bone marrow transplantation (BMT). The failure of mucopolysaccharidosis (MPS) type IIIA patients and adult mice with the condition to respond to this treatment may relate to factors such as impaired migration of donor-derived cells into the brain, insufficient enzyme production and/or secretion by the donor-derived microglial cells, or the age at which treatment is initiated. To explore these possibilities, we treated neonatal MPS IIIA mice with whole unfractionated bone marrow and observed that nucleated blood cell reconstitution occurred to a similar degree in MPS IIIA mice receiving green fluorescent protein (GFP)-expressing normal (treatment group) or MPS IIIA-GFP marrow (control group) and normal mice receiving normal-GFP marrow (control group). Further, similar distribution patterns of GFP(+) normal or MPS IIIA donor-derived cells were observed throughout the MPS IIIA mouse brain. We demonstrate that N-sulfoglucosamine sulfohydrolase (SGSH), the enzyme deficient in MPS IIIA, is produced and secreted in a manner proportional to that of other lysosomal enzymes. However, despite this, overall brain SGSH activity was unchanged in MPS IIIA mice treated with normal marrow and the lysosomal storage burden in whole brain homogenates did not decrease, most likely due to donor-derived cells comprising <0.24% of total recipient brain cells in all groups. This suggests that the failure of MPS IIIA patients and mice to respond to BMT may occur as a result of insufficient donor-derived enzyme production and/or uptake by host brain cells.

Lau AA; Shamsani NJ; Winner LK; Hassiotis S; King BM; Hopwood JJ; Hemsley KM

2013-01-01

 
 
 
 
41

Reversed papilledema in an MPS VI patient with galsulfase (Naglazyme) therapy.  

Science.gov (United States)

MPS VI (mucopolysaccharidosis VI, known as Maroteaux-Lamy syndrome) is a multi-systemic inherited disease, resulting from a deficiency of N-acetylgalactosamine-4-sulfatase, causing accumulation of the glycosaminoglycan (GAG) dermatan sulfate in all tissues. It is one of almost 50 lysosomal storage disorders. Ocular pathology is common in patients with MPS VI, with complications including ocular hypertension, progressive corneal clouding, optic nerve swelling (or papilledema) often associated with communicating hydrocephalus (Ashworth et al., Eye 20(5), 553-563, 2006; Goldberg et al., AJO 69(6), 969-975), and raised intracranial pressure (ICP) progressing to atrophy with loss of vision (Goodrich et al., Loss of vision in MPS VI is a consequence of increased intracranial pressure, 2002). This is the first case report of reversed papilledema and improved visual acuity in an 11-year-old MPS VI patient receiving galsulfase (Naglazyme), an enzyme-replacement therapy (ERT) of recombinant human arylsulfatase B (rhASB) (Harmatz et al., J Pediatr 148(4), 533-539, 2006). PMID:18418554

Koseoglu, Selim T; Harmatz, Paul; Turbeville, Sean; Nicely, Helen

2008-04-17

42

Reversed papilledema in an MPS VI patient with galsulfase (Naglazyme) therapy.  

UK PubMed Central (United Kingdom)

MPS VI (mucopolysaccharidosis VI, known as Maroteaux-Lamy syndrome) is a multi-systemic inherited disease, resulting from a deficiency of N-acetylgalactosamine-4-sulfatase, causing accumulation of the glycosaminoglycan (GAG) dermatan sulfate in all tissues. It is one of almost 50 lysosomal storage disorders. Ocular pathology is common in patients with MPS VI, with complications including ocular hypertension, progressive corneal clouding, optic nerve swelling (or papilledema) often associated with communicating hydrocephalus (Ashworth et al., Eye 20(5), 553-563, 2006; Goldberg et al., AJO 69(6), 969-975), and raised intracranial pressure (ICP) progressing to atrophy with loss of vision (Goodrich et al., Loss of vision in MPS VI is a consequence of increased intracranial pressure, 2002). This is the first case report of reversed papilledema and improved visual acuity in an 11-year-old MPS VI patient receiving galsulfase (Naglazyme), an enzyme-replacement therapy (ERT) of recombinant human arylsulfatase B (rhASB) (Harmatz et al., J Pediatr 148(4), 533-539, 2006).

Koseoglu ST; Harmatz P; Turbeville S; Nicely H

2009-08-01

43

Entanglement spectra of q-deformed AKLT model and MPS  

CERN Multimedia

We calculate exactly the reduced density matrix of matrix product states (MPS). This result enables one to perform analytical studies of entanglement in MPS by elementary algebraic operations on matrices of small rank. We consider the MPS ground states of two anisotropic spin chains. One is a q-deformed Affleck-Kennedy-Lieb-Tasaki (AKLT) model and the other is a general spin-1 quantum antiferromagnet with nearest-neighbor interactions. Our analysis shows how anisotropy affects entanglement on different continuous parameter manifolds.

Santos, Raul A; Korepin, Vladimir E; Klümper, Andreas

2011-01-01

44

Treatment orders failing to protect vulnerable patients, MPs say.  

UK PubMed Central (United Kingdom)

Measures to support people with mental health problems and learning disabilities - such as community treatment orders and deprivation of liberty safeguards - are not working effectively, says an influential group of cross-party MPs.

Duffin C

2013-08-01

45

VDAC3 and Mps1 negatively regulate ciliogenesis.  

UK PubMed Central (United Kingdom)

Centrosomes serve to organize new centrioles in cycling cells, whereas in quiescent cells they assemble primary cilia. We have recently shown that the mitochondrial porin VDAC3 is also a centrosomal protein that is predominantly associated with the mother centriole and modulates centriole assembly by recruiting Mps1 to centrosomes. Here, we show that depletion of VDAC3 causes inappropriate ciliogenesis in cycling cells, while expression of GFP-VDAC3 suppresses ciliogenesis in quiescent cells. Mps1 also negatively regulates ciliogenesis, and the inappropriate ciliogenesis caused by VDAC3 depletion can be bypassed by targeting Mps1 to centrosomes independently of VDAC3. Thus, our data show that a VDAC3-Mps1 module at the centrosome promotes ciliary disassembly during cell cycle entry and suppresses cilia assembly in proliferating cells. Our data also suggests that VDAC3 might be a link between mitochondrial dysfunction and ciliopathies in mammalian cells.

Majumder S; Fisk HA

2013-03-01

46

Senior nurses convince MPs to back campaign for safe staffing.  

UK PubMed Central (United Kingdom)

Members of the Commons health committee were among MPs and peers who signed up to a campaign on safe staffing levels at a high-profile event held by senior nurses in the Houses of Parliament last week.

Sprinks J

2013-10-01

47

Using StaMPS to process RADARSAT images of Askja caldera  

Science.gov (United States)

We have used RADARSAT SLC images from the Canadian Space Agency to create complex interferograms from part of the northern volcanic zone in Iceland. The dataset covers the 2000-2009 period and is a valuable addition to the limited number of good interferometric image pairs available for the area during this time, due to problems with the ERS in 2000 and limited other coverage for part of the period. Here, the Stanford Method for Persistent Scatterers (StaMPS) has been applied to RADARSAT data for the first time. This has enhanced the quality of the interferograms with respect to earlier processing using the Doris software package developed by the Delft Institute for Earth-Oriented Space Research (DEOS), Delft University of Technology. The StaMPS software was adapted for general use with RADARSAT data. Of our particular interest is the Askja caldera and its surroundings which are covered by the images. The Askja caldera has been gradually deflating since 1983 and InSAR images provide an excellent tool to monitor this deformation. In the last two years, previously undetected activity has been observed in the area. Since 2006 small magnitude lower-crustal earthquake swarms have been detected around the Askja caldera (Soosalu et al., 2009). Furthermore, 20 km to the east of Askja in the vicinity of the Upptyppingar mountain, intense persistent deep-seated seismic activity has been recorded since the beginning of 2007 (Jakobsdóttir et al. 2008). Both of these observations, even though very different in character, suggest magma movement at deep levels. The events may relate to recharging of the volcanic systems in the area, or alternatively to flow of magma away from the central part of the Askja system. Detailed monitoring of the area is therefore important. The time series of RADARSAT interferograms shows that Askja continues to subside into summer 2009, but further analysis can test if the rate of subsidence has slowed down in relation to the unrest in the area. We aim to incorporate fluid mechanics constraints into the models used to explain the observed deformation patterns, in order to improve the understanding of the ongoing magma flow which is causing the volcanic unrest. Soosalu H, Key J, White RS, Knox C, Einarsson P, and Jakobsdóttir SS (2009) Lower-crustal earthquakes caused by magma movement beneath Askja volcano on the north Iceland rift. Bull of Volcanol. doi:10.1007/s00445-009-0297-3. Jakobsdóttir SS, Roberts MJ, Gudmundsson GB, Geirsson H and Slunga R (2008) Earthquake swarms at Upptyppingar, North-east Iceland: a sign of magma intrusion? Stud Geophys Geod 52:513-528.

de Zeeuw-van Dalfsen, E.; Hooper, A. J.; Sigmundsson, F.; Pedersen, R.; Jaupart, C. P.

2009-12-01

48

Numerical computation of thermally controlled steam bubble condensation using Moving Particle Semi-implicit (MPS) method  

International Nuclear Information System (INIS)

In the present study, single steam bubble condensation behaviors in subcooled water have been simulated using Moving Particle Semi-implicit (MPS) method. The liquid phase was modeled using moving particles and the two phase interface was set to be a movable boundary which can be tracked by the topological position of the interfacial particles. The interfacial heat transfer was determined according to the heat conduction through the interfacial liquid layer and the coupling between momentum and energy was specially treated. Computational results showed that the bubble experiences various deformations at lower degrees of liquid subcooling while it remains nearly spherical at higher degrees of liquid subcooling. The bubble lifetime is nearly proportional to bubble size and is prolonged at higher system pressures. Bubble lifetime obtained from the MPS method agrees well with the experiments of Kamei and Hirata (1986, 1987), however it is lower than the predictions of Sudhoff et al. (1982). The underestimation is caused by severe bubble deformation at lower degrees of subcooling. The present study exhibits some fundamental characteristics of single steam bubble condensation and is expected to be instructive for further applications of the MPS method to evaluate more complicated bubble dynamics problems.

2010-01-01

49

Two LXXLL motifs in the N terminus of Mps1 are required for Mps1 nuclear import during G(2)/M transition and sustained spindle checkpoint responses.  

UK PubMed Central (United Kingdom)

Spindle assembly checkpoint kinase Mps1 is spatially and temporally regulated during cell cycle progression. Mps1 is predominately localized to the cytosol in interphase cells, whereas it is concentrated on kinetochores in prophase and prometaphase cells. The timing and mechanism of Mps1 redistribution during cell cycle transition is currently poorly understood. Here, we show that Mps1 relocates from the cytosol to the nucleus at the G 2/M boundary prior to nuclear envelope breakdown (NEB). This timely translocation depends on two tandem LXXLL motifs in the N terminus of Mps1, and mutations in either motif abolish Mps1 nuclear accumulation. Furthermore, we found that phosphorylation of Mps1 Ser80 (which is located between the two LXXLL motifs) also plays a role in regulating timely nuclear entry of Mps1. Mps1 that is defective in LXXLL motifs has near wild-type kinase activity. Moreover, the kinase activity of Mps1 appears to be dispensable for nuclear translocation, as inhibition of Mps1 by a highly specific small-molecule inhibitor did not perturb its nuclear entry. Remarkably, translocation-deficient Mps1 can mediate activation of spindle assembly checkpoint response; however, it fails to support a sustained mitotic arrest upon prolonged treatment with nocodazole. The mitotic slippage can be attributed to precocious degradation of Mps1 in the arrested cells. Our studies reveal a novel cell cycle-dependent nuclear translocation signal in the N terminus of Mps1 and suggest that timely nuclear entry could be important for sustaining spindle assembly checkpoint responses.

Zhang X; Yin Q; Ling Y; Zhang Y; Ma R; Ma Q; Cao C; Zhong H; Liu X; Xu Q

2011-08-01

50

Numerical analysis of fuel-coolant interactions in coolant injection mode using MPS  

International Nuclear Information System (INIS)

[en] The numerical method used in this study is the Moving Particle Semi-implicit (MPS) method which is based on moving particles and their interactions. Grids are not necessary, so that large fluid deformation can be calculated without numerical diffusion. Boiling and solidification models are developed for the MPS method. Melt injection is calculated considering boiling and solidification. Clusters of melt particles appear due to solidification. To understand the fundamental physics of the jet penetration, water jet injection into a pool of a denser fluid under non-boiling and isothermal conditions are calculated using the MPS method. The density ratio of the denser fluid to water is 1.88 (fluorinert) or 9.4 (anatomical alloy). The calculation results are compared with experiments, which were conducted in the ALPHA/MUSE facility at JAERI. In the calculation, air entrainment is observed as the experiments due to the jet penetration. However, the maximum jet penetration depth is shallower than the experiments. (author)

1999-01-01

51

CONDENSED MATTER: ELECTRONIC STRUCTURE, ELECTRICAL, MAGNETIC, AND OPTICAL PROPERTIES: Analytical model for reverse characteristics of 4H-SiC merged PN-Schottky (MPS) diodes  

Science.gov (United States)

A new analytical model for reverse characteristics of 4H-SiC merged PN-Schottky diodes (MPS or JBS) is developed. To accurately calculate the reverse characteristics of the 4H-SiC MPS diode, the relationship between the electric field at the Schottky contact and the reverse bias is analytically established by solving the cylindrical Poisson equation after the channel has pinched off. The reverse current density calculated from the Wentzel-Kramers-Brillouin (WKB) theory is verified by comparing it with the experimental result, showing that they are in good agreement with each other. Moreover, the effects of P-region spacing (S) and P-junction depth (Xj) on the characteristics of 4H-SiC MPS are analysed, and are particularly useful for optimizing the design of the high voltage MPS diodes.

Song, Qing-Wen; Zhang, Yu-Ming; Zhang, Yi-Men; Lü, Hong-Liang; Chen, Feng-Ping; Zheng, Qing-Li

2009-12-01

52

Differences in Role-Orientation among Turkish MPs  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Like in many countries, MPs in Turkey are confronted with contradictory role expectations. However, in a context characterized by high turnover, there seems to be no strong standardization of role learning, neither through the main ways of transmission of political roles (party and elected offices) ...

Massicard, Elise

53

Mps1 Phosphorylation Sites Regulate the Function of Centrin 2 in Centriole Assembly  

Digital Repository Infrastructure Vision for European Research (DRIVER)

We show that while Centrin2 is dispensable for centriole assembly, it is an Mps1 substrate that stimulates canonical and aberrant centriole assembly by two different Mps1-dependent mechanisms, HsSas-6–dependent and –independent. Centrin2 phosphorylation is also required for the ability of Mps1 to dr...

Yang, Ching-Hui; Kasbek, Christopher; Majumder, Shubhra; Yusof, Adlina Mohd; Fisk, Harold A.

54

Operation of the Brookhaven MPS II Facility  

International Nuclear Information System (INIS)

[en] The BNL Multiparticle Spectrometer has recently been equipped with a set of narrow cell drift chambers employing a novel, compact, inexpensive, readout scheme. This has given an order of magnitude improvement in beam rate as well as better spatial resolution. Two experiments have been completed in the first year of operation, a good test of the system. This type of a drift chamber arrangement is ideal for use at high luminosity hadron colliders

1983-01-01

55

VDAC3 regulates centriole assembly by targeting Mps1 to centrosomes  

Science.gov (United States)

Centrioles are duplicated during S-phase to generate the two centrosomes that serve as mitotic spindle poles during mitosis. The centrosomal pool of the Mps1 kinase is important for centriole assembly, but how Mps1 is delivered to centrosomes is unknown. Here we have identified a centrosome localization domain within Mps1 and identified the mitochondrial porin VDAC3 as a protein that binds to this region of Mps1. Moreover, we show that VDAC3 is present at the mother centriole and modulates centriole assembly by recruiting Mps1 to centrosomes.

Majumder, Shubhra; Slabodnick, Mark; Pike, Amanda; Marquardt, Joseph; Fisk, Harold A.

2012-01-01

56

Bronchoscopy and airway management in patients with mucopolysaccharidoses (MPS).  

UK PubMed Central (United Kingdom)

INTRODUCTION: Mucopolysaccharidoses (MPS) are a group of lysosomal storage disorders characterized by tissue deposition of glycosaminoglycans (GAG). Their musculoskeletal abnormalities and the GAG storage in the airway result in increased risk for patients undergoing anesthesia. This study evaluates a multi-disciplinary airway management approach and reports upper and lower airway findings of flexible bronchoscopy performed during these procedures. METHODS: This is a retrospective study over 10 years evaluating approaches to and outcomes of airway management and bronchoscopic findings in this patient group. RESULTS: Thirty-one patients underwent a total of 105 anesthetic events of which 74 involved multiple surgical services. The majority of patients were either MPS I (n?=?9) or MPS II (n?=?19). The median age was 8.6 years (range 1.1-24 years). Airway management by anesthesiologists alone occurred in 31 cases including natural airway (n?=?7), perilaryngeal airway (n?=?7), oral or nasal intubation (n?=?7) or tracheostomy (n?=?6) and emergent fiberoptic intubation in four cases. In 74 of the procedures, flexible bronchoscopy was performed which included fiberoptic intubation in 22 cases. Post-operative complications occurred in eight cases mostly when prolonged airway instrumentation had occurred. The most frequent findings on bronchoscopy were GAG deposits/adenoid hypertrophy in 72%, laryngomalacia in 31% and lower airway deposits and/or tracheobronchomalacia in 46% of procedures. Deposits of GAG were seen in patients as young as 4 years of age. CONCLUSION: Our experience demonstrates that a multidisciplinary approach and combined surgeries in MPS provides for safe airway management and allows diagnostic assessments for further patient care without added risks. Significant, multi-factorial airway compromise may occur already in early childhood including upper and lower airway GAG deposits.

Muhlebach MS; Shaffer CB; Georges L; Abode K; Muenzer J

2013-06-01

57

Numerical analysis of molten core-concrete interaction using MPS method  

Energy Technology Data Exchange (ETDEWEB)

Moving particle semi-implicit (MPS) method uses particles for discretization of fluids. Governing equations are transformed to particle interactions. Grids are not necessary. This enables us to analyze multi-fluid and multi-phase flows with large deformation of interfaces. In the present study, a two-dimensional code is developed for molten core-concrete interaction (MCCI) based on the MPS method. Heat transfer is calculated without any specific correlations. Solid is simply represented by fixed particles. A particle can be changed to a moving (fluid) or fixed (solid) particle corresponding to its enthalpy. The developed code is applied to SWISS-2 experiment. The calculation geometry is x-y two dimensions though the experiment was r-z two dimensions. Nucleate boiling and radiation heat transfers are considered between the melt and the water pool. Only heat conduction is assumed among the melt pool, concrete and MgO (side wills). Natural convection in the melt pool is considered using Boussinesq's approximation. Gas release and volume contraction accompanied by the concrete ablation are ignored. Calculated heat flux to the water pool agrees well with the experiment, though the ablation speed in the concrete is a little slower. A stable crust is formed in a short time after water is poured in and the heat flux to the water pool rapidly decreases. The shape of the crust is like a bridge due to the natural convection in the melt pool. (author)

Koshizuka, S.; Sekine, M.; Oka, Y. [Tokyo Univ., Tokai, Ibaraki (Japan); Obata, H. [Japan Atomic Power Co., Tokyo (Japan)

2000-11-01

58

Effective mass trigger at the Brookhaven Multi-Particle Spectrometer (MPS)  

Energy Technology Data Exchange (ETDEWEB)

An effective mass trigger for use at the Brookhaven Multiparticle Spectrometer (MPS) is described. It is a microprocessor based device using extensive fast memory attached to proportional wire chambers in the MPS magnetic field. It will select kinematic quantities unique to the reaction being studied, thereby permitting higher sensitivities and a reduction in data-processing cost for MPS experiments. The principles of operation for this trigger, and the results of simulations to assess its performance, are presented.

Willen, E H

1980-01-01

59

Exploring phase transitions by finite-entanglement scaling of MPS in the 1D ANNNI model  

CERN Multimedia

We use the finite-entanglement scaling of infinite matrix product states (iMPS) to explore supposedly infinite order transitions. This universal method may have lower computational costs than finite-size scaling. To this end, we study possible MPS-based algorithms to find the ground states of the transverse axial next-nearest-neighbor Ising (ANNNI) model in a spin chain with first and second neighbor interactions and frustration. The ground state has four distinct phases with transitions of second order and one of supposedly infinite order, the Kosterlitz-Thouless transition. To explore phase transitions in the model, we study general quantities such as the correlation length, entanglement entropy and the second derivative of the energy with respect to the external field, and test the finite-entanglement scaling. We propose a scaling ansatz for the correlation length of a non-critical system in order to explore infinite order transitions. This method provides considerably less computational costs compared to ...

Nagy, Adam

2011-01-01

60

Mip1 associates with both the Mps1 kinase and actin and is required for cell cortex stability and anaphase spindle positioning  

Science.gov (United States)

The Mps1 family of protein kinases contributes to cell cycle control by regulating multiple microtubule cytoskeleton activities. We have uncovered a new Mps1 substrate that provides a novel link between Mps1 and the actin cytoskeleton. We have identified a conserved human Mps1 (hMps1) interacting pr...

 
 
 
 
61

Dynamic wall-shear stress measurements in turbulent pipe flow using the micro-pillar sensor MPS3  

International Nuclear Information System (INIS)

The micro-pillar wall-shear stress sensor MPS3 has been used to measure the dynamic wall-shear stress in turbulent pipe flow. The sensor device consists of a flexible micro-pillar which extends from the wall into the viscous sublayer. The pillar-tip deflection caused by the exerting fluid forces serves as a measure for the local wall-shear stress. The pillar is statically calibrated in linear shear flow. A second-order estimate of the pillar dynamic response based on experimentally determined sensor characteristics shows the potential of the present sensor configuration to also measure the dynamic wall-shear stress. The quality of the micro-pillar shear stress sensor MPS3 to correctly determine the skin friction will be shown by measuring the wall friction in a well-defined fully developed turbulent pipe flow at Reynolds numbers Reb based on the bulk velocity Ub and the pipe diameter D in the range of Reb=10,000-20,000. The results demonstrate a convincing agreement of the mean and dynamic wall-shear stress obtained with the MPS3 sensor technique with analytical, experimental, and numerical results from the literature.

2008-01-01

62

An MPS-BNS Mixed Strategy Based on Game Theory for Wireless Mesh Networks  

Digital Repository Infrastructure Vision for European Research (DRIVER)

To achieve a valid effect of wireless mesh networks against selfish nodes and selfish behaviors in the packets forwarding, an approach named mixed MPS-BNS strategy is proposed in this paper. The proposed strategy is based on the Maximum Payoff Strategy (MPS) and the Best Neighbor Strategy (BNS). In ...

Huang, S. Q.; Wang, G. C.; Zhen, H. H.; Zhang, Z.

63

The safety of anginine in patients undergoing myocardial perfusion scintigraphy (MPS)- a nurses' perspective  

International Nuclear Information System (INIS)

[en] Full text: Anginine-augmented MPS improves detection rate of myocardial viability and reversible ischaemia. However, anginine can cause significant hypotension. The aims of this study were to determine i) safety of anginine in patients with an intermediate to high risk of myocardial ischaemia undergoing MPS; ii) frequency and degree of fall in systolic blood pressure (SBP); iii) BP monitoring requirements; and iv) type of patient(s) prone to side effects. 63 patients (33M, 30F, mean age-67.2y) were included. Each was cannulated, drank two glasses of water, and lay supine prior to administration of anginine (1 x puff sublingually). 99Tcm-MIBI was administered 3-5 minutes later. BP measurements were obtained every five minutes for 20 minutes. SBP fell in 46/63 patients (range 5 - 40mmHg, mean 1 6mmHg, in 14 fall >20mmHg), and rose in 14/63. Maximal fall occurred 5-15 minutes post-administration of anginine (14 at 5min, 15 at 10min, 17 at 15min), returning toward baseline by 20 minutes in all patients. Seven patients developed a headache and two light-headedness; in all SBP fell >10mmHg. The quality of the scans was unaffected. There were 22(35%) abnormal studies - 14 reversible defects, two fixed defects, six cardiomyopathy (mean SBP tall 8.1mmHg, 8.6mmHg with normal study). LVEF was obtained in 33 patients; SBP fell in 24 (mean LVEF 57.8%), and rose in nine (mean LVEF 56.8%). The frequency and extent of hypotension in relation to age, sex, LVEF, or scan findings was not statistically significant. Anginine is sate to administer to patients undergoing MPS. Careful monitoring of the BP is recommended during the initial 20 minutes post-administration. No particular patient type was identified at higher risk. Copyright (2000) The Australian and New Zealand Society of Nuclear Medicine Inc

2000-01-01

64

Heterologous Expression and Purification Systems for Structural Proteomics of Mammalian Membrane Proteins  

Directory of Open Access Journals (Sweden)

Full Text Available Membrane proteins (MPs) are responsible for the interface between the exterior and the interior of the cell. These proteins are implicated in numerous diseases, such as cancer, cystic fibrosis, epilepsy, hyperinsulinism, heart failure, hypertension and Alzheimer's disease. However, studies on these disorders are hampered by a lack of structural information about the proteins involved. Structural analysis requires large quantities of pure and active proteins. The majority of medically and pharmaceutically relevant MPs are present in tissues at very low concentration, which makes heterologous expression in large-scale production-adapted cells a prerequisite for structural studies. Obtaining mammalian MP structural data depends on the development of methods that allow the production of large quantities of MPs. This review focuses on the different heterologous expression systems, and the purification strategies, used to produce large amounts of pure mammalian MPs for structural proteomics.

Isabelle Mus-Veteau

2006-01-01

65

Mps1 Phosphorylation Sites Regulate the Function of Centrin 2 in Centriole Assembly  

Science.gov (United States)

The nondegradable Mps1?12/13 protein drives centriole overproduction, suggesting that Mps1 phosphorylates a subset of centrosomal proteins to drive the assembly of new centrioles. Here we identify three Mps1 phosphorylation sites within the centriolar protein Centrin 2 (Cetn2). Although centrioles can be assembled in the absence of Cetn2, centriole assembly is attenuated in the absence of Cetn2. While wild-type Cetn2 can compensate for this attenuation, a nonphosphorylatable version cannot. In addition, overexpressing Cetn2 causes Mps1-dependent centriole overproduction that requires each of the three Mps1 phosphorylation sites within Cetn2 and is greatly exacerbated by mimicking phosphorylation at any of these sites. Wild-type Cetn2 generates excess foci that are competent as mitotic spindle poles in HsSas-6–depleted cells, suggesting that Cetn2 can organize a subset of centriolar proteins independently of cartwheels. However, centriole overproduction caused by a phosphomimetic Cetn2 mutant requires HsSas-6, suggesting that Cetn2 phosphorylation stimulates the canonical centriole assembly pathway. Moreover, in the absence of Cetn2, Mps1?12/13 cannot drive the production of mature centrioles capable of recruiting ?-Tubulin, and a nonphosphorylatable Cetn2 mutant cannot compensate for this defect and exacerbates Cetn2 depletion. Together, our data suggest that Mps1-dependent phosphorylation of Cetn2 stimulates the canonical centriole assembly pathway.

Yang, Ching-Hui; Kasbek, Christopher; Majumder, Shubhra; Yusof, Adlina Mohd

2010-01-01

66

R&D ERL: Machine Protection System  

Energy Technology Data Exchange (ETDEWEB)

The Machine Protection System (MPS) is a device-safety system that is designed to prevent damage to hardware by generating interlocks, based upon the state of input signals generated by selected sub-system. It exists to protect key machinery such as the 50 kW and 1 MW RF Systems. When a fault state occurs, the MPS is capable of responding with an interlock signal within several microseconds. The Machine Protection System inputs are designed to be fail-safe. In addition, all fault conditions are latched and time-stamped. The ERL MPS is based on a National Instruments hardware platform, and is programmed by utilizing National Instruments development environment for a visual programming language.

Altinbas, Z.

2010-01-01

67

Random pharmacokinetic profiles of EC-MPS in children with autoimmune disease  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Therapy with mycophenolate mofetil (MMF) has become a valuable therapeutic option in children with autoimmune disease. MMF prescription in children with autoimmune diseases differs from that in transplant recipients in terms of different dosing regimen, and concomitant administration of other immunosuppressive medications. Recently, another formulation of the same active compound, mycophenolic acid (MPA), has become available as enteric-coated Mycophenolate Sodium (EC-MPS). Dosing and pharmacokinetics of EC-MPS in pediatric autoimmune disease have never been studied. Methods We therefore performed a pilot study on 6 patients, who were treated with EC-MPS. All patients underwent 1-2 full 10-point pharmacokinetic (PK) profiles over a 12-hour dosing interval. We compared the results with that of 22 similar patients on MMF therapy. Results Median EC-MPS dose was 724 mg/m2 (range 179-933 mg/m2). The MPA Area-Under-The-(Time-Concentration)-Curves (AUCs) on MMF and EC-MPS were comparable (54.4 mg × h/L on MMF and 44.0 mg × h/L on EC-MPS, n.s., Mann Whitney). After correcting for bioequivalence, the dose-normalized AUCs were also similar on both the formulations. However, PK profiles on EC-MPS were quite random, and time to maximum concentration varied from 30 minutes to 720 minutes. The concentration at six-hour correlated best with the AUC. This was different from a homogenous PK-profile on MPA. Conclusions EC-MPS has a different PK profile from MMF. The data suggest that patients on EC-MPS must undergo a complete PK profile to assess adequate exposure. The 6-hour concentration provides an estimate of the exposure and should be targeted between 3-4 mg/L.

Filler Guido; Sharma Ajay; Levy Deborah M; Yasin Abeer

2010-01-01

68

Development of a machine protection system for the Superconducting Beam Test Facility at Fermilab  

CERN Multimedia

Fermilab's Superconducting RF Beam Test Facility currently under construction will produce electron beams capable of damaging the acceleration structures and the beam line vacuum chambers in the event of an aberrant accelerator pulse. The accelerator is being designed with the capability to operate with up to 3000 bunches per macro-pulse, 5Hz repetition rate and 1.5 GeV beam energy. It will be able to sustain an average beam power of 72 KW at the bunch charge of 3.2 nC. Operation at full intensity will deposit enough energy in niobium material to approach the melting point of 2500 {\\deg}C. In the early phase with only 3 cryomodules installed the facility will be capable of generating electron beam energies of 810 MeV and an average beam power that approaches 40 KW. In either case a robust Machine Protection System (MPS) is required to mitigate effects due to such large damage potentials. This paper will describe the MPS system being developed, the system requirements and the controls issues under consideratio...

Warner, A; Church, M; Neswold, R

2012-01-01

69

Structural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint).  

Science.gov (United States)

The SAC (spindle assembly checkpoint) is a surveillance system that ensures the timely and accurate transmission of the genetic material to offspring. The process implies kinetochore targeting of the mitotic kinases Bub1 (budding uninhibited by benzamidine 1), BubR1 (Bub1 related) and Mps1 (monopolar spindle 1), which is mediated by the N-terminus of each kinase. In the present study we report the 1.8 Å (1 Å=0.1 nm) crystal structure of the TPR (tetratricopeptide repeat) domain in the N-terminal region of human Mps1. The structure reveals an overall high similarity to the TPR motif of the mitotic checkpoint kinases Bub1 and BubR1, and a number of unique features that include the absence of the binding site for the kinetochore structural component KNL1 (kinetochore-null 1; blinkin), and determinants of dimerization. Moreover, we show that a stretch of amino acids at the very N-terminus of Mps1 is required for dimer formation, and that interfering with dimerization results in mislocalization and misregulation of kinase activity. The results of the present study provide an important insight into the molecular details of the mitotic functions of Mps1 including features that dictate substrate selectivity and kinetochore docking. PMID:23067341

Thebault, Philippe; Chirgadze, Dimitri Y; Dou, Zhen; Blundell, Tom L; Elowe, Sabine; Bolanos-Garcia, Victor M

2012-12-15

70

Structural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint).  

UK PubMed Central (United Kingdom)

The SAC (spindle assembly checkpoint) is a surveillance system that ensures the timely and accurate transmission of the genetic material to offspring. The process implies kinetochore targeting of the mitotic kinases Bub1 (budding uninhibited by benzamidine 1), BubR1 (Bub1 related) and Mps1 (monopolar spindle 1), which is mediated by the N-terminus of each kinase. In the present study we report the 1.8 Å (1 Å=0.1 nm) crystal structure of the TPR (tetratricopeptide repeat) domain in the N-terminal region of human Mps1. The structure reveals an overall high similarity to the TPR motif of the mitotic checkpoint kinases Bub1 and BubR1, and a number of unique features that include the absence of the binding site for the kinetochore structural component KNL1 (kinetochore-null 1; blinkin), and determinants of dimerization. Moreover, we show that a stretch of amino acids at the very N-terminus of Mps1 is required for dimer formation, and that interfering with dimerization results in mislocalization and misregulation of kinase activity. The results of the present study provide an important insight into the molecular details of the mitotic functions of Mps1 including features that dictate substrate selectivity and kinetochore docking.

Thebault P; Chirgadze DY; Dou Z; Blundell TL; Elowe S; Bolanos-Garcia VM

2012-12-01

71

Parental social support, coping strategies, resilience factors, stress, anxiety and depression levels in parents of children with MPS III (Sanfilippo syndrome) or children with intellectual disabilities (ID).  

UK PubMed Central (United Kingdom)

Mucopolysaccharidosis type III (MPS III, Sanfilippo syndrome) is a lysosomal storage disorder, caused by a deficiency in one of four enzymes involved in the catabolism of the glycosaminoglycan heparan sulphate. It is a degenerative disorder, with a progressive decline in children's intellectual and physical functioning. There is currently no cure for the disorder. To date there is a paucity of research on how this disorder impacts parents psychological functioning. Specifically, research in the area has failed to employ adequate control groups to assess if the impact of this disorder on parents psychological functioning differs from parenting a child with intellectual disability (ID). The current study examined child behaviour and parental psychological functioning in 23 parents of children with MPS III and 23 parents of children with ID. Parents completed postal questionnaires about their child's behaviour and abilities and their own psychological functioning. Parents of children with MPS III reported fewer behavioural difficulties as their child aged, more severe level of intellectual disability, and similar levels of perceived social support, coping techniques, stress, anxiety and depression levels as parents of children with ID. Both groups of parents scored above the clinical cut off for anxiety and depression. Parents of children with MPS III rated themselves as significantly less future-orientated and goal directed than parents of children with ID. Services should develop support packages for parents of children with MPS III that incorporate an understanding of the unique stressors and current-difficulty approach of this population. Future research should examine gender differences between parental psychological functioning, using mixed qualitative and quantitative approaches, and utilise matched developmental level and typically developing control groups.

Grant S; Cross E; Wraith JE; Jones S; Mahon L; Lomax M; Bigger B; Hare D

2013-03-01

72

Performance of Four Newly Developed Upland Cotton Strains Under Lower Sindh Conditions  

Directory of Open Access Journals (Sweden)

Full Text Available Four newly developed strains; MPS-2, MPS-4, MPS-7, and MPS-11, were tested against two commercial, high yielding varieties CRIS-9 and NIAB-78, for two years (1996 and 1997) for seed cotton yield per hectare, ginning out turn percentage (Got), staple length and boll weight. The highest yield of 2209 kg /ha was obtained by MPS-2, followed by MPS-11 (2090 kg /ha). The increase of top yielding strain MPS-2 over commercial varieties CRIS-9 and NIAB-78 were 13.7 and 18.3%, respectively. The highest ginning out turn (38.3 %) was given by MPS-7 and highest staple length (27.0 mm) was measured in MPS-7.

M. S. Chang; M. A. Chang; A. R. Lakho; A. W. Soomro; A. A. Memon

2002-01-01

73

An MPS-BNS mixed strategy based on game theory for wireless mesh networks.  

UK PubMed Central (United Kingdom)

To achieve a valid effect of wireless mesh networks against selfish nodes and selfish behaviors in the packets forwarding, an approach named mixed MPS-BNS strategy is proposed in this paper. The proposed strategy is based on the Maximum Payoff Strategy (MPS) and the Best Neighbor Strategy (BNS). In this strategy, every node plays a packet forwarding game with its neighbors and records the total payoff of the game. After one round of play, each player chooses the MPS or BNS strategy for certain probabilities and updates the strategy accordingly. In MPS strategy, each node chooses a strategy that will get the maximum payoff according to its neighbor's strategy. In BNS strategy, each node follows the strategy of its neighbor with the maximum total payoff and then enters the next round of play. The simulation analysis has shown that MPS-BNS strategy is able to evolve to the maximum expected level of average payoff with faster speed than the pure BNS strategy, especially in the packets forwarding beginning with a low cooperation level. It is concluded that MPS-BNS strategy is effective in fighting against selfishness in different levels and can achieve a preferable performance.

Huang SQ; Wang GC; Zhen HH; Zhang Z

2013-01-01

74

An MPS-BNS mixed strategy based on game theory for wireless mesh networks.  

Science.gov (United States)

To achieve a valid effect of wireless mesh networks against selfish nodes and selfish behaviors in the packets forwarding, an approach named mixed MPS-BNS strategy is proposed in this paper. The proposed strategy is based on the Maximum Payoff Strategy (MPS) and the Best Neighbor Strategy (BNS). In this strategy, every node plays a packet forwarding game with its neighbors and records the total payoff of the game. After one round of play, each player chooses the MPS or BNS strategy for certain probabilities and updates the strategy accordingly. In MPS strategy, each node chooses a strategy that will get the maximum payoff according to its neighbor's strategy. In BNS strategy, each node follows the strategy of its neighbor with the maximum total payoff and then enters the next round of play. The simulation analysis has shown that MPS-BNS strategy is able to evolve to the maximum expected level of average payoff with faster speed than the pure BNS strategy, especially in the packets forwarding beginning with a low cooperation level. It is concluded that MPS-BNS strategy is effective in fighting against selfishness in different levels and can achieve a preferable performance. PMID:23401672

Huang, S Q; Wang, G C; Zhen, H H; Zhang, Z

2013-01-17

75

Liga developer apparatus system  

Energy Technology Data Exchange (ETDEWEB)

A system to fabricate precise, high aspect ratio polymeric molds by photolithograpic process is described. The molds for producing micro-scale parts from engineering materials by the LIGA process. The invention is a developer system for developing a PMMA photoresist having exposed patterns comprising features having both very small sizes, and very high aspect ratios. The developer system of the present invention comprises a developer tank, an intermediate rinse tank and a final rinse tank, each tank having a source of high frequency sonic agitation, temperature control, and continuous filtration. It has been found that by moving a patterned wafer, through a specific sequence of developer/rinse solutions, where an intermediate rinse solution completes development of those portions of the exposed resist left undeveloped after the development solution, by agitating the solutions with a source of high frequency sonic vibration, and by adjusting and closely controlling the temperatures and continuously filtering and recirculating these solutions, it is possible to maintain the kinetic dissolution of the exposed PMMA polymer as the rate limiting step.

Boehme, Dale R. (Pleasanton, CA); Bankert, Michelle A. (San Francisco, CA); Christenson, Todd R. (Albuquerque, NM)

2003-01-01

76

Development of heating system  

International Nuclear Information System (INIS)

[en] The detailed designs and development of components of NBI, RF, ECH, and LHCD heating and current drive system have been performed. The prototype ion source for the KSTAR NBI system and the beam line components such as calorimeter, neutralizer, bending magnet, and ion dump had been developed. The power supplies for the stable beam of 120 kV and 65 A including acceleration power supply, deceleration power supply, arc power supply, and filament power supply have been developed. Finally a KSATR NB test facility has been completed at KAERI to test and upgrade the ion source and the beam line components. The RF system is under development. Antenna has been fabricated and tested. Transmission components (vacuum feedthrough, impedance matching and water-cooled transmission line) for transmitting MW level of power have been developed. For transmitter, we optimized performance of 100kW transmitter and completed the fabrication of 300 kW transmitter. We will finalize the procurement specification of 2 MW transmitter system in the third phase. The detailed design of a 500 kW, 84 GHz ECH system has been completed. The gyrotron has been fabricated and successfully tested at Communications and Power Industries(CPI), USA. It is delivered to POSTECH, and under short pulse conditioning test with a pulse modulator operated at 20 ?s with 60 Hz repetition rate and a acceleration power supply (APS). The ECH transmission line components are being purchased from General Atomics (GA), USA. The LH frequency of the 2.0 MW LHCD system is chosen to 5.0 GHz for extending the density limit condition. The LHCD system is under design process. The basic design of the 5.0 GHz LHCD launcher (coupler) has been finished using the HFSS and ANSYS programs

2002-01-01

77

A DSP-Based Beam Current Monitoring System for Machine Protection Using Adaptive Filtering  

Energy Technology Data Exchange (ETDEWEB)

The CEBAF accelerator at Jefferson Lab is currently using an analog beam current monitoring (BCM) system for its machine protection system (MPS), which has a loss accuracy of 2 micro-amps. Recent burn-through simulations predict catastrophic beam line component failures below 1 micro-amp of loss, resulting in a blind spot for the MPS. Revised MPS requirements target an ultimate beam loss accuracy of 250 nA. A new beam current monitoring system has been developed which utilizes modern digital receiver technology and digital signal processing concepts. The receiver employs a direct-digital down converter integrated circuit, mated with a Jefferson Lab digital signal processor VME card. Adaptive filtering is used to take advantage of current-dependent burn-through rates. Benefits of such a system include elimination of DC offsets, generic algorithm development, extensive filter options, and interfaces to UNIX-based control systems.

J. Musson; H. Dong; R. Flood; C. Hovater; J. Hereford

2001-06-01

78

A DSP-Based Beam Current Monitoring System for Machine Protection Using Adaptive Filtering  

International Nuclear Information System (INIS)

The CEBAF accelerator at Jefferson Lab is currently using an analog beam current monitoring (BCM) system for its machine protection system (MPS), which has a loss accuracy of 2 micro-amps. Recent burn-through simulations predict catastrophic beam line component failures below 1 micro-amp of loss, resulting in a blind spot for the MPS. Revised MPS requirements target an ultimate beam loss accuracy of 250 nA. A new beam current monitoring system has been developed which utilizes modern digital receiver technology and digital signal processing concepts. The receiver employs a direct-digital down converter integrated circuit, mated with a Jefferson Lab digital signal processor VME card. Adaptive filtering is used to take advantage of current-dependent burn-through rates. Benefits of such a system include elimination of DC offsets, generic algorithm development, extensive filter options, and interfaces to UNIX-based control systems

2001-01-01

79

RSMASS system model development  

Energy Technology Data Exchange (ETDEWEB)

RSMASS system mass models have been used for more than a decade to make rapid estimates of space reactor power system masses. This paper reviews the evolution of the RSMASS models and summarizes present capabilities. RSMASS has evolved from a simple model used to make rough estimates of space reactor and shield masses to a versatile space reactor power system model. RSMASS uses unique reactor and shield models that permit rapid mass optimization calculations for a variety of space reactor power and propulsion systems. The RSMASS-D upgrade of the original model includes algorithms for the balance of the power system, a number of reactor and shield modeling improvements, and an automatic mass optimization scheme. The RSMASS-D suite of codes cover a very broad range of reactor and power conversion system options as well as propulsion and bimodal reactor systems. Reactor choices include in-core and ex-core thermionic reactors, liquid metal cooled reactors, particle bed reactors, and prismatic configuration reactors. Power conversion options include thermoelectric, thermionic, Stirling, Brayton, and Rankine approaches. Program output includes all major component masses and dimensions, efficiencies, and a description of the design parameters for a mass optimized system. In the past, RSMASS has been used as an aid to identify and select promising concepts for space power applications. The RSMASS modeling approach has been demonstrated to be a valuable tool for guiding optimization of the power system design; consequently, the model is useful during system design and development as well as during the selection process. An improved in-core thermionic reactor system model RSMASS-T is now under development. The current development of the RSMASS-T code represents the next evolutionary stage of the RSMASS models. RSMASS-T includes many modeling improvements and is planned to be more user-friendly. RSMASS-T will be released as a fully documented, certified code at the end of 1998. A radioisotope space power system model RISMASS is also under development. RISMASS will optimize and predict system masses for radioisotope power sources coupled with close-spaced thermionic diodes. Although RSMASS-D models have been developed for a broad variety of space nuclear power and propulsion systems, only a few concepts will be included in the releasable RSMASS-T computer code. A follow-on effort is recommended to incorporate all previous models as well as solar power system models into one general code. The proposed Space Power and propulsion system MASS (SPMASS) code would provide a consistent analysis tool for comparing a very broad range of alternative power and propulsion systems for any required power level and operating conditions. As for RSMASS-T the SPMASS model should be a certified, fully documented computer code available for general use. The proposed computer program would provide space mission planners with the capability to quickly and cost effectively explore power system options for any space mission. The code should be applicable for power requirements from as low as a few milliwatts (solar and isotopic system options) to many megawatts for reactor power and propulsion systems.

Marshall, A.C.; Gallup, D.R.

1998-07-01

80

AI system development  

Energy Technology Data Exchange (ETDEWEB)

The Decision Aids Test Environment (DATE) has been devised to aid strategic defense-related decisionmaking. DATE's kit for knowledge-representation and inference consists of three tools, respectively for Bayesian network development, belief structures development, and the establishment of a rule-based system. Attention is presently given to the three simulation tools used to test a decision aid: the Computer-Aided Discrete Event Tool, the Threat-Maker Tool, and the Engagement Driver.

Gately, M.P.; Bellman, K.; Landauer, C.; Wakefield, G.S.; Newman, B.E. (U.S. Army, Strategic Defense Command, Huntsville, AL (United States) Aerospace Corp., Los Angeles, CA (United States))

1991-10-01

 
 
 
 
81

The Wasp System: an open source environment for managing and analyzing genomic data.  

UK PubMed Central (United Kingdom)

The challenges associated with the management, analysis and interpretation of assays based on massively-parallel sequencing (MPS) are both individually complex and numerous. We describe what we believe to be the appropriate solution, one that represents a departure from traditional computational biology approaches. The Wasp System is an open source, distributed package written in Spring/J2EE that creates a foundation for development of an end-to-end solution for MPS-based experiments or clinical tests. Recognizing that one group will be unable to solve these challenges in isolation, we describe a nurtured open source development model that will allow the software to be collectively used, shared and developed. The ultimate goal is to emulate resources such as the Virtual Observatory of the astrophysics community, enabling computationally-inexpert scientists and clinicians to explore and interpret their MPS data. Here we describe the current implementation and development of the Wasp System and the roadmap for its community development.

McLellan AS; Dubin RA; Jing Q; Broin PÓ; Moskowitz D; Suzuki M; Calder RB; Hargitai J; Golden A; Greally JM

2012-12-01

82

Numerical analysis of crust formation in molten core-concrete interaction using MPS method  

Energy Technology Data Exchange (ETDEWEB)

A two-dimensional code is developed for molten core-concrete interaction (MCCI) based on Moving Particle Semi-implicit (MPS) method. Heat transfer is calculated without any specific correlations. A particle can be changed to a moving (fluid) or fixed (solid) particle corresponding to its enthalpy, which provide the phase change model for particles. The phase change model is verified by one-dimensional test calculations. Nucleate boiling and radiation heat transfers are considered between the core debris and the water pool. The developed code is applied to SWISS-2 experiment in which stainless steel is used as the melt material. Calculated heat flux to the water pool agrees well with the experiment, though the ablation speed in the concrete is a little slower. A stable crust is formed in a short time after water is poured in and the heat flux to the water pool rapidly decreases. MACE-M0 using corium is also analyzed. The ablation speed of concrete is slower than that of SWISS-2 because of low heat conduction in corium. An unlimited geometry is analyzed by setting the cyclic boundary condition on the sides. When the crust is broken by the decomposition gas, heat transfer to the water pool is kept high for a longer time because the crust re-formation is delayed. (author)

Seiichi, Koshizuka; Shoji, Matsuura; Mizue, Sekine; Yoshiaki, Oka [Tokyo Univ., Tokai, Ibaraki (Japan). Nuclear Engineering Research Lab.; Hiroyuki, Obata [Japan Atomic Power Co., Tokyo (Japan)

2001-07-01

83

UV-C irradiation delays mitotic progression by recruiting Mps1 to kinetochores.  

UK PubMed Central (United Kingdom)

The effect of UV irradiation on replicating cells during interphase has been studied extensively. However, how the mitotic cell responds to UV irradiation is less well defined. Herein, we found that UV-C irradiation (254 nm) increases recruitment of the spindle checkpoint proteins Mps1 and Mad2 to the kinetochore during metaphase, suggesting that the spindle assembly checkpoint (SAC) is reactivated. In accordance with this, cells exposed to UV-C showed delayed mitotic progression, characterized by a prolonged chromosomal alignment during metaphase. UV-C irradiation also induced the DNA damage response and caused a significant accumulation of ?-H2AX on mitotic chromosomes. Unexpectedly, the mitotic delay upon UV-C irradiation is not due to the DNA damage response but to the relocation of Mps1 to the kinetochore. Further, we found that UV-C irradiation activates Aurora B kinase. Importantly, the kinase activity of Aurora B is indispensable for full recruitment of Mps1 to the kinetochore during both prometaphase and metaphase. Taking these findings together, we propose that UV irradiation delays mitotic progression by evoking the Aurora B-Mps1 signaling cascade, which exerts its role through promoting the association of Mps1 with the kinetochore in metaphase.

Zhang X; Ling Y; Wang W; Zhang Y; Ma Q; Tan P; Song T; Wei C; Li P; Liu X; Ma RZ; Zhong H; Cao C; Xu Q

2013-04-01

84

Drosophila Polo regulates the spindle assembly checkpoint through Mps1-dependent BubR1 phosphorylation.  

Science.gov (United States)

Maintenance of genomic stability during eukaryotic cell division relies on the spindle assembly checkpoint (SAC) that prevents mitotic exit until all chromosomes are properly attached to the spindle. Polo is a mitotic kinase proposed to be involved in SAC function, but its role has remained elusive. We demonstrate that Polo and Aurora B functional interdependency comprises a positive feedback loop that promotes Mps1 kinetochore localization and activity. Expression of constitutively active Polo restores normal Mps1 kinetochore levels even after Aurora B inhibition, highlighting a role for Polo in Mps1 recruitment to unattached kinetochores downstream of Aurora B. We also show that Mps1 kinetochore localization is required for BubR1 hyperphosphorylation and formation of the 3F3/2 phosphoepitope. This is essential to allow recruitment of Cdc20 to unattached kinetochores and the assembly of anaphase-promoting complex/cyclosome-inhibitory complexes to levels that ensure long-term SAC activity. We propose a model in which Polo controls Mps1-dependent BubR1 phosphorylation to promote Cdc20 kinetochore recruitment and sustained SAC function. PMID:23685359

Conde, Carlos; Osswald, Mariana; Barbosa, João; Moutinho-Santos, Tatiana; Pinheiro, Diana; Guimarães, Sofia; Matos, Irina; Maiato, Helder; Sunkel, Claudio E

2013-05-17

85

Characterization of light-cured dental composites prepared from Bis-GMA/TEEDGDMA and Bis-GMA/MPS mistures  

Scientific Electronic Library Online (English)

Full Text Available Abstract in english The aim of this study was to prepare light-cured dental composites and to evaluate their physical, chemical and mechanical properties. Experimental composites were prepared from 2, 2 bis [4-(2-hidroxy 3-metacriloxypropoxi) phenyl] propane (Bis-GMA), tetraethyleneglycol dimethacrylate (TEEGDMA), 3-methacryloxypropyl trimethoxysilane (MPS) and a hybrid filler consisting of quartz and colloidal silica particles (Aerosil 90). The initiation system was based on the pair Campho (more) rquinone (CQ) / N, N dimethylaminoethylmethacrylate (DMAEMA). The experimental composites and a commercial dental composite used as reference (Charisma®) were submitted to determinations of depth of cure, water absorption and solubility, compressive and diametral tensile strengths, and elastic modulus, according to the indications of the ISO standards. The experimental resins presented adequate values for most of the analyzed properties, except for compressive strengths. In the Bis-GMA/ MPS/quartz-aerosil composite a better integration between filler and matrix was observed. The Bis-GMA/TEEGDMA/quartz-aerosil composite showed the best performance in regards to depth of cure, solubility in water, diametral tensile strength and elastic modulus. The properties of this composite were better than those of the commercial reference material, except for compressive strength.

Veranes, Y.; Correa, D.; Martin, J. M.; Krael, R.; Alvarez, R.

2006-01-01

86

Trauma system development.  

UK PubMed Central (United Kingdom)

The word 'trauma' describes the disease entity resulting from physical injury. Trauma is one of the leading causes of death worldwide and deaths due to injury look set to increase. As early as the 1970s, it became evident that centralisation of resources and expertise could reduce the mortality rate from serious injury and that organisation of trauma care delivery into formal systems could improve outcome further. Internationally, trauma systems have evolved in various forms, with widespread reports of mortality and functional outcome benefits when major trauma management is delivered in this way. The management of major trauma in England is currently undergoing significant change. The London Trauma System began operating in April 2010 and others throughout England became operational this year. Similar systems exist internationally and continue to be developed. Anaesthetists have been and continue to be involved with all levels of trauma care delivery, from the provision of pre-hospital trauma and retrieval teams, through to chronic pain management and rehabilitation of patients back into society. This review examines the international development of major trauma care delivery and the components of a modern trauma system.

Lendrum RA; Lockey DJ

2013-01-01

87

Mucopolysaccharidosis: cardiologic features and effects of enzyme-replacement therapy in 24 children with MPS I, II and VI.  

UK PubMed Central (United Kingdom)

We determined the cardiologic features of children with MPS I, II and VI, and evaluated the effect of enzyme-replacement therapy (ERT) on cardiac disease. Twenty-four children aged 1-18 years with MPS I, II or VI were prospectively evaluated with echocardiogram and electrocardiogram from the start of enzyme-replacement therapy up to 6 years of treatment. At start of therapy, 66% had abnormal cardiac geometric features. Left-ventricular mass index (LVMI) was increased in half of the patients, due mainly to concentric hypertrophy in MPS I and II and to eccentric hypertrophy in MPS VI. Regurgitation was most severe in a subgroup of young MPS VI patients (<5 years) at the mitral valve. At baseline, all patients had abnormal valves. The ECG showed no clear rhythm or conduction abnormalities; neither, in most patients, did it reflect the hypertrophy. After ERT, the LVMI Z-score normalized in 70% of the patients who had a Z-score?>?2. LVMI Z-scores decreased significantly in patients with MPS I and MPS II (p?=?0.04 and p?=?0.032). Despite ERT, valve regurgitation increased in 60% of the patients. We conclude that all our MPS patients have cardiac abnormalities. The most severe cardiac disease was observed in a subgroup of young MPS VI patients. While ERT had an effect on LVMI and IVSd, it apparently had little or none on valve regurgitation.

Brands MM; Frohn-Mulder IM; Hagemans ML; Hop WC; Oussoren E; Helbing WA; van der Ploeg AT

2013-03-01

88

Unique protein signature of circulating microparticles in systemic lupus erythematosus.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To characterize the uniqueness of proteins associated with circulating subcellular material in systemic lupus erythematosus patients compared with healthy controls and with patients with other chronic autoimmune diseases. METHODS: Using differential centrifugation and high sensitivity nano-liquid chromatography-tandem mass spectrometry we systematically profile proteins of MPs from patients with SLE (n=12), systemic sclerosis (SSc, n=6), rheumatoid arthritis (RA, n=6), and healthy controls (HC, n=12). RESULTS: We identify 531 unique proteins and show statistically highly significant differences between HC and SLE regarding the abundance of 268 proteins. Almost half of >2-fold increased proteins are complement proteins and immunoglobulins (increased 100-4000 times). MP immunoglobulin and complement loads also distinguish SLE from RA and SSc and correlate strongly with clinical SLE severity. Subsets of microtubule proteins, fibronectin, 14-3-3?, and desmosomal proteins are >95 times increased while ficolin-2 and galectin-3 binding protein are 5-10 times increased. Decreased proteins in SLE-MPs are cytoskeletal, mitochondrial, and organelle proteins including lysosome-associated membrane glycoprotein 1 and transforming growth factor ?1. CONCLUSIONS: The data show that SLE patients have fewer MPs of normal protein composition and increased numbers of MPs that are heavily tagged for removal. SLE MPs are unique and specific proteins represent novel leads for the examination of the pathogenesis and development of new treatments of SLE. © 2013 American College of Rheumatology.

Ostergaard O; Nielsen CT; Iversen LV; Tanassi JT; Knudsen S; Jacobsen S; Heegaard NH

2013-07-01

89

Signature classification development system  

Energy Technology Data Exchange (ETDEWEB)

Discontinuities of various types and sizes may be introduced into a material or component during the manufacturing process or during the service life. During a nondestructive evaluation (NDE), the inspector must accept or reject the material/component based on the interpretation of signatures recorded by the inspection equipment. In certain cases, the NDE signature has nuances that cannot be recognized by a trained inspector, thus the ability to accurately determine the presence of a discontinuity or undesirable property in the material is diminished. Advanced advisor systems are desired to assist the inspector in determining the acceptability of a part during inspection. In order to meet this need, the US Army Material Technology Laboratory funded the Applied Physics Laboratory of the Johns Hopkins University and the Carderock Division of the Naval Surface Warfare Center to jointly develop a prototype Signature Classification Development System (SCDS). The objective of the SCDS is to provide computer analysis tools to classify signatures from generic inspection systems. The SCDS organizes the sensor data, performs digital signal processing and generates user defined feature parameters for input to classification algorithms. Features are calculated from the time-domain and the power spectrum of the signature. By applying artificial neural network algorithms, the SCDs will classify the recorded signature. Future enhancements include the addition of classical statistic techniques for feature selection and generation of run-time classifiers for field inspections.

Brown, L.M. [Naval Surface Warfare Center, Annapolis, MD (United States). Carderock Div.; Lin, J.S.; Newman, R.W. [Johns Hopkins Univ., Laurel, MD (United States). Applied Physics Lab.

1993-12-31

90

Geological disposal system development  

Energy Technology Data Exchange (ETDEWEB)

Spent fuel inventories to be disposed of finally and design base spent fuel were determined. Technical and safety criteria for a geological repository system in Korea were established. Based on the properties of spent PWR and CANDU fuels, seven repository alternatives were developed and the most promising repository option was selected by the pair-wise comparison method from the technology point of view. With this option preliminary conceptual design studies were carried out. Several module, e.g., gap module, congruent release module were developed for the overall assessment code MASCOT-K. The prominent overseas databases such as OECD/NEA FEP list were are fully reviewed and then screened to identify the feasible ones to reflect the Korean geo-hydrological conditions. In addition to this the well known scenario development methods such as PID, RES were reviewed. To confirm the radiological safety of the proposed KAERI repository concept the preliminary PA was pursued. Thermo-hydro-mechanical analysis for the near field of repository were performed to verify thermal and mechanical stability for KAERI repository system. The requirements of buffer material were analyzed, and based on the results, the quantitative functional criteria for buffer material were established. The hydraulic and swelling property, mechanical properties, and thermal conductivity, the organic carbon content, and the evolution of pore water chemistry were investigated. Based on the results, the candidate buffer material was selected.

Kang, Chul Hyung; Kuh, J. E.; Kim, S. K. and others

2000-04-01

91

Geological disposal system development  

International Nuclear Information System (INIS)

Spent fuel inventories to be disposed of finally and design base spent fuel were determined. Technical and safety criteria for a geological repository system in Korea were established. Based on the properties of spent PWR and CANDU fuels, seven repository alternatives were developed and the most promising repository option was selected by the pair-wise comparison method from the technology point of view. With this option preliminary conceptual design studies were carried out. Several module, e.g., gap module, congruent release module were developed for the overall assessment code MASCOT-K. The prominent overseas databases such as OECD/NEA FEP list were are fully reviewed and then screened to identify the feasible ones to reflect the Korean geo-hydrological conditions. In addition to this the well known scenario development methods such as PID, RES were reviewed. To confirm the radiological safety of the proposed KAERI repository concept the preliminary PA was pursued. Thermo-hydro-mechanical analysis for the near field of repository were performed to verify thermal and mechanical stability for KAERI repository system. The requirements of buffer material were analyzed, and based on the results, the quantitative functional criteria for buffer material were established. The hydraulic and swelling property, mechanical properties, and thermal conductivity, the organic carbon content, and the evolution of pore water chemistry were investigated. Based on the results, the candidate buffer material was selected

2000-01-01

92

The machine protection system for the R&D energy recovery LINAC  

Energy Technology Data Exchange (ETDEWEB)

The Machine Protection System (MPS) is a device-safety system that is designed to prevent damage to hardware by generating interlocks, based upon the state of input signals generated by selected sub-systems. It protects all the key machinery in the R&D Project called the Energy Recovery LINAC (ERL) against the high beam current. The MPS is capable of responding to a fault with an interlock signal within several microseconds. The ERL MPS is based on a National Instruments CompactRIO platform, and is programmed by utilizing National Instruments' development environment for a visual programming language. The system also transfers data (interlock status, time of fault, etc.) to the main server. Transferred data is integrated into the pre-existing software architecture which is accessible by the operators. This paper will provide an overview of the hardware used, its configuration and operation, as well as the software written both on the device and the server side.

Altinbas, Z.; Kayran, D.; Jamilkowski, J.; Lee, R.C.; Oerter, B.

2011-03-28

93

Developments in multiuser systems  

Energy Technology Data Exchange (ETDEWEB)

Workstations for applications as diverse as data entry and process control are in increasing demand but until recently have remained in the cost range of minicomputers and mainframes. Two developments are opening these applications environments to wider exploitation by computer manufacturers: the maturation of networking techniques and the availability of more powerful microprocessors. Both have the effect of lowering the average cost of workstations, but at present they differ in their price/performance/functionality characteristics. This paper focuses on the application of microprocessors in multiuser systems.

Borrell, J.

1983-09-01

94

Power Systems Development Facility  

International Nuclear Information System (INIS)

The objective of the PSDF would be to provide a modular facility which would support the development of advanced, pilot-scale, coal-based power systems and hot gas clean-up components. These pilot-scale components would be designed to be large enough so that the results can be related and projected to commercial systems. The facility would use a modular approach to enhance the flexibility and capability for testing; consequently, overall capital and operating costs when compared with stand-alone facilities would be reduced by sharing resources common to different modules. The facility would identify and resolve technical barrier, as well as-provide a structure for long-term testing and performance assessment. It is also intended that the facility would evaluate the operational and performance characteristics of the advanced power systems with both bituminous and subbituminous coals. Five technology-based experimental modules are proposed for the PSDF: (1) an advanced gasifier module, (2) a fuel cell test module, (3) a PFBC module, (4) a combustion gas turbine module, and (5) a module comprised of five hot gas cleanup particulate control devices. The final module, the PCD, would capture coal-derived ash and particles from both the PFBC and advanced gasifier gas streams to provide for overall particulate emission control, as well as to protect the combustion turbine and the fuel cell

1993-01-01

95

Saccharomyces cerevisiae MPS2 Encodes a Membrane Protein Localized at the Spindle Pole Body and the Nuclear Envelope  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The MPS2 (monopolar spindle two) gene is one of several genes required for the proper execution of spindle pole body (SPB) duplication in the budding yeast Saccharomyces cerevisiae (Winey et al., 1991). We report here that the MPS2 gene encodes an essential 44-kDa protein with two putative coiled-co...

Muñoz-Centeno, María de la Cruz; McBratney, Susan; Monterrosa, Antonio; Byers, Breck; Mann, Carl; Winey, Mark

96

Bone marrow transplantation in patients with storage diseases: a developing country experience  

Directory of Open Access Journals (Sweden)

Full Text Available Bone marrow transplantation (BMT) is a therapeutic option for patients with genetic storage diseases. Between 1979 and 2002, eight patients, four females and four males (1 to 13 years old) were submitted to this procedure in our center. Six patients had mucopolysaccharidosis (MPS I in 3; MPS III in one and MPS VI in 2), one had adrenoleukodystrophy (ALD) and one had Gaucher disease. Five patients had related and three unrelated BMT donor. Three patients developed graft versus host disease (two MPS I and one MPS VI) and died between 37 and 151 days after transplantation. Five patients survived 4 to 16 years after transplantation. Three patients improved (one MPS I; one MPS VI and the Gaucher disease patient), one patient had no disease progression (ALD) and in one patient this procedure did not change the natural course of the disease (MPS III).

Lange Marcos C.; Teive Hélio A.G.; Troiano André R.; Bitencourt Marco; Funke Vaneuza A.M.; Setúbal Daniela C.; Zanis Neto José; Medeiros Carlos R.; Werneck Lineu C.; Pasquini Ricardo; Bonfim Carmen M.S.

2006-01-01

97

Cognitive and neuroradiological improvement in three patients with attenuated MPS I treated by laronidase.  

UK PubMed Central (United Kingdom)

Stem cell transplantation is not appropriate first-line treatment for attenuated phenotypes of mucopolysaccharidosis type I (MPS I). In three patients with attenuated MPSA I treated by laronidase, Patients 2 and 3 displayed significant cognitive improvement within 2years; Patients 1 and 3 displayed improvement on MRI scans of the brain.

Valayannopoulos V; Boddaert N; Barbier V; Le Merrer M; Caillaud C; de Lonlay P

2010-05-01

98

Cognitive and neuroradiological improvement in three patients with attenuated MPS I treated by laronidase.  

Science.gov (United States)

Stem cell transplantation is not appropriate first-line treatment for attenuated phenotypes of mucopolysaccharidosis type I (MPS I). In three patients with attenuated MPSA I treated by laronidase, Patients 2 and 3 displayed significant cognitive improvement within 2years; Patients 1 and 3 displayed improvement on MRI scans of the brain. PMID:20106688

Valayannopoulos, V; Boddaert, N; Barbier, V; Le Merrer, M; Caillaud, C; de Lonlay, P

2010-01-04

99

Design, baseline characteristics, and early findings of the MPS VI (mucopolysaccharidosis VI) Clinical Surveillance Program (CSP).  

UK PubMed Central (United Kingdom)

OBJECTIVE: To outline the design, baseline data, and 5-year follow-up data of patients with mucopolysaccharidosis (MPS) VI enrolled in the Clinical Surveillance Program (CSP), a voluntary, multinational, observational program. METHODS: The MPS VI CSP was opened in 2005 to collect, for at least 15 years, observational data from standard clinical and laboratory assessments of patients with MPS VI. Baseline and follow-up data are documented by participating physicians in electronic case report forms. RESULTS: Between September 2005 and March 2010 the CSP enrolled 132 patients, including 123 who received enzyme replacement therapy (ERT) with galsulfase. Median age at enrolment was 13 years (range 1-59). Mean baseline data showed impaired growth, hepatosplenomegaly, and reduced endurance and pulmonary function. The most common findings were heart valve disease (90%), reduced visual acuity (79%), impaired hearing (59%), and hepatosplenomegaly (54%). Follow-up data up to 5 years in patients with pre- and post-ERT measurements showed a decrease in urinary glycosaminoglycans and increases in height and weight in patients <16 years and suggested reductions in liver and spleen size and improvements in endurance and pulmonary function after ERT was started. Vision, hearing, and cardiac function were unchanged. Safety data were in line with previous reports. CONCLUSIONS: The CSP represents the largest cross-sectional study of MPS VI to date. This first report provides information on the design and implementation of the program and population statistics for several clinical variables in patients with MPS VI. Data collected over 5 years suggest that ERT provides clinical benefit and is well-tolerated with no new safety concerns.

Hendriksz CJ; Giugliani R; Harmatz P; Lampe C; Martins AM; Pastores GM; Steiner RD; Leão Teles E; Valayannopoulos V

2013-03-01

100

Progress report on a study of inelastic K/sup -/ reactions with polarized target in the Brookhaven MPS  

Energy Technology Data Exchange (ETDEWEB)

The University of Massachusetts full-scale polarized-target run with the Brookhaven MPS was successfully carried out in late 1980, many years after being proposed. This study of K/sup -/ inelastic processes represents the first application of the spin refrigerator target, and is unusual among polarized-target experiments in its use of a large multiparticle spectrometer for complex final states. It is also unusual in its emphasis on inelastic channels of S = -1 baryon resonances. Analysis of data (at 2.3 GeV c.m.) now in progress will establish the usefulness of the target system and also provide new information for the SU(6)/sub W/ (or other) quark model. 3 references, 1 figure.

Button-Shafer, J.

1983-01-01

 
 
 
 
101

MPS [More Power Submarine] cables could be MIND [Mass Impregnated Non-Draining Cable] blowing for 1200 MW links  

Energy Technology Data Exchange (ETDEWEB)

ABB High Voltage Cables AB started the MPS (More Power Submarine cables) project in 1993 with a view to exploring new technology opportunities. The goal is to design and type test a submarine HVDC cable for a capacity of 1200 MW at 600 kV. On the day before ABB announced its success in winning the contract for the world`s largest ever submarine HVDC link project for the gigantic Bakun project in Malaysia, ABB Power Systems described progress to date at a symposium in Karlskrona. The proceedings included a test demonstration on an extruded cable which eventually broke down at a stress of over 935 kV -not in the insulation itself but in the end terminations. The electric field was in excess of 200 kV/mm which is higher than ever before reported. (UK)

Anon.

1996-07-01

102

Human MPS1 Kinase Is Required for Mitotic Arrest Induced by the Loss of CENP-E from KinetochoresD?  

Digital Repository Infrastructure Vision for European Research (DRIVER)

We have determined that the previously identified dual-specificity protein kinase TTK is the human orthologue of the yeast MPS1 kinase. Yeast MPS1 (monopolar spindle) is required for spindle pole duplication and the spindle checkpoint. Consistent with the recently identified vertebrate MPS1 homologu...

Liu, Song-Tao; Chan, Gordon K.T.; Hittle, James C.; Fujii, Gregory; Lees, Emma; Yen, Tim J.

103

Development of Microprocessor Systems.  

Science.gov (United States)

Development, manufacturing, and applications of highly integrated microprocessor and microcomputer IC components are surveyed. Projects reported on include: development of an n channel silicon gate MOS program for the 8 bit microprocessor family 8080, 825...

G. Sandner I. Bromme G. Eberhard H. Ellwanger R. Helow

1979-01-01

104

Master Pump Shutdown MPS Software Quality Assurance Plan (SQAP)  

Energy Technology Data Exchange (ETDEWEB)

The MPSS Software Quality Assurance (SQAP) describes the tools and strategy used in the development of the MPSS software. The document also describes the methodology for controlling and managing changes to the software.

BEVINS, R.R.

2000-09-20

105

Master Pump Shutdown MPS Software Quality Assurance Plan (SQAP)  

International Nuclear Information System (INIS)

[en] The MPSS Software Quality Assurance (SQAP) describes the tools and strategy used in the development of the MPSS software. The document also describes the methodology for controlling and managing changes to the software

2000-01-01

106

Preparation of P(DVB-co-MPS) inorganic-organic hybrid polymer microspheres  

Science.gov (United States)

A novel inorganic-organic hybrid polymer microspheres were facilely synthesised by distillation-precipitation polymerization in absence of any stabilizer or surfcant. The process were conducted with [3-(Methacryloyloxy) propyl] trimethoxysilan (MPS) as monomer, divinyl benzene (DVB) as cross linking agent and azobisisobutyronitrile (AIBN) as initator in acetonitrile. A series of silica nanoparticles were prepared in accordance with the volume ratio of MPS, which was varied in the range of 10% to 50%. However, there is no microspheres obtained while the ratio up to 50%. Products were charactered by transmission electron micrograph (TEM) and fourier transform infrared spectroscopy (FTIR). We may infer it from the constructional formular and FTIR graph that there were silicon hydroxyl remained in the microsphere surface.

Wu, Chunrong; Zhang, Jimei; Dai, Zhao; Chen, Xiaoyu

2010-07-01

107

Ubiquitin Ligase Ufd2 Is Required for Efficient Degradation of Mps1 Kinase  

Science.gov (United States)

Ufd2 is a U-box-containing ubiquitylation enzyme that promotes ubiquitin chain assembly on substrates. The physiological function of Ufd2 remains poorly understood. Here, we show that ubiquitylation and degradation of the cell cycle kinase Mps1, a known target of the anaphase-promoting complex E3, require Ufd2 enzyme. Yeast cells lacking UFD2 exhibit altered chromosome stability and several spindle-related phenotypes, expanding the biological function of Ufd2. We demonstrate that Ufd2-mediated Mps1 degradation is conserved in humans. Our results underscore the significance of Ufd2 in proteolysis and further suggest that Ufd2-like enzymes regulate far more substrates than previously envisioned.

Liu, Chang; van Dyk, Dewald; Choe, Vitnary; Yan, Jing; Majumder, Shubhra; Costanzo, Michael; Bao, Xin; Boone, Charles; Huo, Keke; Winey, Mark; Fisk, Harold; Andrews, Brenda; Rao, Hai

2011-01-01

108

Numerical analysis of jet injection mechanism of fuel-coolant interactions using MPS  

Energy Technology Data Exchange (ETDEWEB)

The numerical method used in this study is Moving Particle Semi-implicit (MPS) method which is based on moving particles and their interactions. Grids are not necessary, so that large fluid deformation can be calculated without numerical diffusion. To understand the fundamental physics of the jet penetration, water jet injection into a pool of a denser fluid under non-boiling and isothermal conditions is calculated using the MPS method. The density ratio of the denser fluid (Fluorinert) to water is 1.88. The calculation results are compared with experiments which were conducted in the ALPHA/MUSE facility at JAERI. In three-dimensional calculation, the penetration behavior agrees with the experiment. It is found that the jet penetration process is divided to two stages and, at the first stage, the coolant jet can penetrate deeper than existing correlations of breakup length. (author)

Ikeda, Hirokazu; Koshizuka, Seiichi; Oka, Yoshiaki [Tokyo Univ., Tokai, Ibaraki (Japan). Nuclear Engineering Research Lab; Park, Hyun Sun; Sugimoto, Jun [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

2000-11-01

109

Framework for control system development  

International Nuclear Information System (INIS)

Control systems being developed for the present generation of accelerators will need to adapt to changing machine and operating state conditions. Such systems must also be capable of evolving over the life of the accelerator operation. In this paper we present a framework for the development of adaptive control systems

1991-01-01

110

Problems in Information Systems Development  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The purpose of this thesis is to find the general problems in information systems development. In the thesis, the author will first introduce the research approach of analysis needs, and then talk about the basic idea of an information system and information system development as well as the process...

Zhang, Xiang

111

Cloning and molecular characterization of BumaMPs1, a novel metalloproteinases from the venom of scorpion Buthus martensi Karsch.  

UK PubMed Central (United Kingdom)

Scorpion venoms metalloproteinase is involved in a number of important biological, physiological and pathophysiological processes. In this work, a complete sequence of metalloproteinase was first obtained from venom of scorpion Buthus martensi and named as BumaMPs1. BumaMPs1 has 393 amino acid residues containing with a molecular mass of 44.53 kDa, showing an isoelectric point of 5.66. The primary sequence analysis indicated that the BumaMPs1 contains a zinc-binding motif (HELGHNLGISH), methionine-turn motif (YIM), disintegrin-like domain (ETCD) and N-glycosylation site. The multiple alignment of its deduced amino acid sequence and those of other metalloproteinase showed a high structural similarly, mainly among class reprolysin proteases. The phylogenetic analysis showed early divergence and independent evolution of BumaMPs1 from other metalloproteinase.

Xia X; Ma Y; Xue S; Wang A; Tao J; Zhao Y; Zhang Q; Liu R; Lu S

2013-10-01

112

Development of a multifunctional particle spectrometer for space radiation imaging  

Energy Technology Data Exchange (ETDEWEB)

For future exploration of the solar system, the European Space Agency (ESA) is planning missions to Mercury (BepiColombo), the Sun (SolarOrbiter) and to the moons of Jupiter and Saturn. The expected intensity of radiation during such missions is hazardous for the scientific instruments and the satellite. To extend the lifetime of the satellite and its payload a multifunctional particle spectrometer (MPS) is being developed. The basic function of the MPS is to send an alarm signal to the satellite control system during periods of high radiation. In addition the MPS is a scientific instrument that will unfold the composition of the different contributing particles on-line by the dE/dx versus E method. The energy spectrum and angular distribution of the particles will be recorded as well. This article describes the main requirements and the base line design for the MPS. A readout scheme consisting of a 32 channel ASIC from IDEAS is proposed and the signal filtering algorithm will run on a digital signal processor based on FPGA technology. Results are shown from prototype calibration studies with a proton beam.

Maddox, Erik [Cosine Research B.V, Niels Bohrweg 11, 2333 CA, Leiden (Netherlands)], E-mail: emaddox@cosine.nl; Palacios, Alex; Lampridis, Dimitris; Kraft, Stefan [Cosine Research B.V, Niels Bohrweg 11, 2333 CA, Leiden (Netherlands); Owens, Alan; Tomuta, Dana [Office of Advanced Concepts and Science Payloads, ESA/ESTEC, Noordwijk (Netherlands); Ostendorf, Reint [Kernfysisch Versneller Instituut, Zernikelaan 25, 9747 AA, Groningen (Netherlands)

2008-06-11

113

Rapid-acquisition myocardial perfusion scintigraphy (MPS) on a novel gamma camera using multipinhole collimation and miniaturized cadmium-zinc-telluride (CZT) detectors: prognostic value and diagnostic accuracy in a 'real-world' nuclear cardiology service.  

UK PubMed Central (United Kingdom)

AIMS: To study the prognostic value of rapid-acquisition adenosine stress-rest myocardial perfusion scintigraphy (MPS) on a gamma camera using multipinhole collimation and cadmium-zinc-telluride (CZT) detectors. The secondary aim was to assess the diagnostic accuracy of the technique compared with invasive coronary angiography. METHODS AND RESULTS: Retrospective analysis of 1109 consecutive patients undergoing MPS in a routine clinical setting on a high-efficiency multipinhole gamma camera. MPS acquisition, performed with a standard injection of 550 MBq of (99m)Tc-tetrofosmin, required a mean (±SD) scanning time of 322 ± 51 s. The hard cardiac event rate at a median (inter-quartile range) follow-up of 624 (552-699) days was 0.4% (95% CI 0.1-1.1) in patients with no significant perfusion abnormality versus 6.8% (95% CI 4.3-10.7%, P < 0.001) in those with an abnormal scan. In a sub-group of 165 patients, comparison with obstructive coronary artery disease on X-ray angiography gave a sensitivity, specificity, positive predictive value, negative predictive value, and accuracy for rapid-acquisition MPS of 84% (95% CI 74-91), 79% (95% CI 68-87), 82% (95% CI 72-89), 81% (95% CI 70-89), and 82% (95% CI 73-89), respectively. CONCLUSIONS: MPS performed on a CZT solid-state detector camera with multipinhole collimation is an evolutionary development that provides reliable prognostic and diagnostic information, while significantly reducing image acquisition time.

Chowdhury FU; Vaidyanathan S; Bould M; Marsh J; Trickett C; Dodds K; Clark TP; Sapsford RJ; Dickinson CJ; Patel CN; Thorley PJ

2013-08-01

114

Liferay Portal Systems Development  

CERN Document Server

This book focuses on teaching by example. Every chapter provides an overview, and then dives right into hands-on examples so you can see and play with the solution in your own environment. This book is for Java developers who don't need any prior experience with Liferay portal. Although Liferay portal makes heavy use of open source frameworks, no prior experience of using these is assumed.

Yuan, Jonas X

2012-01-01

115

Development of FAME Animation System  

Energy Technology Data Exchange (ETDEWEB)

In order to monitor an animation of magnetohydrodynamic equilibrium calculated by the FAME-II (Fast Analyzer for Magnetohydrodynamic Equilibrium-II) system, a FAME Animation System was developed. This system provides automatically the animation on workstations connected to network with the same period of JT-60U discharge sequence. Then, the system can supply the important information for JT-60U operators to determine control parameters of the succeeding discharge. This report describes the overview of the FAME Animation System. (author)

Hasegawa, Yukihiro; Hamamatsu, Kiyotaka; Shirai, Hiroshi; Matsuda, Toshiaki [Department of Fusion Plasma Research, Naka Fusion Research Establishment, Japan Atomic Energy Research Institute, Naka, Ibaraki (Japan); Watanabe, Hideto; Itakura, Hirofumi; Tahata, Yasunori

1999-02-01

116

HLW Disposal System Development  

International Nuclear Information System (INIS)

A KRS is suggested through design requirement analysis of the buffer and the canister which are the constituent of disposal system engineered barrier and HLW management plans are proposed. In the aspect of radionuclide retention capacity, the thickness of the buffer is determined 0.5m, the shape to be disc and ring and the dry density to be 1.6 g/cm3. The maximum temperature of the buffer is below 100 .deg. which meets the design requirement. And bentonite blocks with 5 wt% of graphite showed more than 1.0 W/mK of thermal conductivity without the addition of sand. The result of the thermal analysis for proposed double-layered buffer shows that decrease of 7 .deg. C in maximum temperature of the buffer. For the disposal canister, the copper for the outer shell material and cast iron for the inner structure material is recommended considering the results analyzed in terms of performance of the canisters and manufacturability and the geochemical properties of deep groundwater sampled from the research area with granite, salt water intrusion, and the heavy weight of the canister. The results of safety analysis for the canister shows that the criticality for the normal case including uncertainty is the value of 0.816 which meets subcritical condition. Considering nation's 'Basic Plan for Electric Power Demand and Supply' and based on the scenario of disposing CANDU spent fuels in the first phase, the disposal system that the repository will be excavated in eight phases with the construction of the Underground Research Laboratory (URL) beginning in 2020 and commissioning in 2040 until the closure of the repository is proposed. Since there is close correlation between domestic HLW management plans and front-end/back-end fuel cycle plans causing such a great sensitivity of international environment factor, items related to assuring the non-proliferation and observing the international standard are showed to be the influential factor and acceptability of HLW management plans to be the influential factor of making decision for social acceptability of nuclear power.

2007-01-01

117

Developing a hospital information system  

Digital Repository Infrastructure Vision for European Research (DRIVER)

This project descibes a basic definition, implementation and importance of Hospital Information Systems.The project goes further practically by developing a Hospital infomation system(HIS) that can be used in small to medium size medical centers. Lastly this project takes (HIS)to less developed coun...

Ezeife, Tobechukwu

118

Bone marrow transplantation in patients with storage diseases: a developing country experience/ Transplante de medula óssea em pacientes com doença de acúmulo: experiência de um país em desenvolvimento  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese O transplante de medula óssea é uma opção terapêutica para os pacientes com doenças de acúmulo. Entre 1979 e 2002, oito pacientes, quatro femininos e quatro masculinos (entre um e 13 anos de idade) foram submetidos a este procedimento em nosso centro. Seis pacientes apresentavam mucopolissacaridose (MPS I em 3; MPS III em um e MPS VI em 2), um paciente apresentava adrenoleucodistrofia e um apresentava doença de Gaucher. Cinco pacientes receberam o transplante de d (more) oador aparentado e três de doador não aparentado. Três pacientes desenvolveram doença do enxerto versus hospedeiro (dois com MPS I e um com MPS VI) e faleceram entre 37 e 151 dias após o transplante. Cinco pacientes sobreviveram entre 4 e 16 anos após o transplante. Três tiveram melhora clínica (um MPS I, um MPS VI e o paciente com doença de Gaucher), um paciente não apresentou progressão da doença (adrenoleucodistrofia) e um paciente não teve alteração da história natural da doença (MPS III). Abstract in english Bone marrow transplantation (BMT) is a therapeutic option for patients with genetic storage diseases. Between 1979 and 2002, eight patients, four females and four males (1 to 13 years old) were submitted to this procedure in our center. Six patients had mucopolysaccharidosis (MPS I in 3; MPS III in one and MPS VI in 2), one had adrenoleukodystrophy (ALD) and one had Gaucher disease. Five patients had related and three unrelated BMT donor. Three patients developed graft ve (more) rsus host disease (two MPS I and one MPS VI) and died between 37 and 151 days after transplantation. Five patients survived 4 to 16 years after transplantation. Three patients improved (one MPS I; one MPS VI and the Gaucher disease patient), one patient had no disease progression (ALD) and in one patient this procedure did not change the natural course of the disease (MPS III).

Lange, Marcos C.; Teive, Hélio A.G.; Troiano, André R.; Bitencourt, Marco; Funke, Vaneuza A.M.; Setúbal, Daniela C.; Zanis Neto, José; Medeiros, Carlos R.; Werneck, Lineu C.; Pasquini, Ricardo; Bonfim, Carmen M.S.

2006-03-01

119

Weapons Systems Development Decision Support System.  

Science.gov (United States)

Defense budget cuts and the recent peace dividend have made weapons systems development decisions increasingly more difficult and subject to scrutiny. Meticulous planning is required to ensure tax dollars are spent wisely and effectively. This thesis pres...

R. K. Boyd

1992-01-01

120

ISE System Development Methodology Manual  

Energy Technology Data Exchange (ETDEWEB)

The Information Systems Engineering (ISE) System Development Methodology Manual (SDM) is a framework of life cycle management guidelines that provide ISE personnel with direction, organization, consistency, and improved communication when developing and maintaining systems. These guide-lines were designed to allow ISE to build and deliver Total Quality products, and to meet the goals and requirements of the US Department of Energy (DOE), Westinghouse Savannah River Company, and Westinghouse Electric Corporation.

Hayhoe, G.F.

1992-02-17

 
 
 
 
121

Microkernel Development for Embedded Systems  

Directory of Open Access Journals (Sweden)

Full Text Available This paper presents the development of a microkernel with a device driver controller for embedded systems. The implementation was done in C language aiming low cost microcontrollers. The proposed system allowed to perform soft real-time activities while keeping the drivers and the application isolated by a secure layer. The callback system proved itself extremely simple to use while still maintaining the security of the system regarding the temporal constraints.

Rodrigo Maximiano Antunes de Almeida; Luis Henrique de Carvalho Ferreira; Carlos Henrique Valério

2013-01-01

122

Power Systems Development Facility, PFBC system perspectives  

Energy Technology Data Exchange (ETDEWEB)

Southern Company Services (SCS) has investigated the feasibility of constructing a Power Systems Development Facility (PSDF) at the Southem Company`s Clean Coal Research Center in Wilsonville, Alabama. The PSDF combines a number of pilot-scale test facilities at a single site to reduce the overall capital and operating cost compared to individual stand-alone facilities, while continuing the DOE/METC`s objective of carrying out meaningful systems and component testing for advanced coal-based power generation development. The intent of the PSDF is to provide a flexible test facility that can be used to develop advanced power system components and assess the integration and control issues of these advanced power systems. The facility would provide a resource for rigorous, long-term testing and performance assessment of hot stream cleanup devices in an integrated environment, permitting evaluation of not only the cleanup devices but also other components in an integrated operation.

Griswold, G.H. [Southern Co. Services, Inc., Birmingham, AL (United States); Boyd, T.J. [Electric Power Research Inst., Palo Alto, CA (United States); Fankhanel, M.O. [Kellogg (M.W.) Co. (United States); Crumm, C.J. [Foster Wheeler Corp. (United States); Pontius, D.H. [SRI International, Menlo Park, CA (United States)

1993-09-01

123

Abnormal gangliosides are localized in lipid rafts in Sanfilippo (MPS3a) mouse brain.  

UK PubMed Central (United Kingdom)

Allogenic stem cell transplantation can reduce lysosomal storage of heparan sulfate-derived oligosaccharides by up to 27 % in Sanfilippo MPS3a brain, but does not reduce the abnormal storage of sialolactosylceramide (G(M3)) or improve neurological symptoms, suggesting that ganglioside storage is in a non-lysosomal compartment. To investigate this further we isolated the Triton X100-insoluble at 4 °C, lipid raft (LR) fraction from a sucrose-density gradient from cerebral hemispheres of a 7 month old mouse model of Sanfilippo MPS3a and age-matched control mouse brain. HPLC/MS/MS analysis revealed the expected enrichment of normal complex gangliosides, ceramides, galatosylceramides and sphingomyelin enrichment in this LR fraction. The abnormal HS-derived oligosaccharide storage material was in the Triton X100-soluble at 4 °C fractions (8-12),whereas both GM3 and sialo[GalNAc]lactosylceramide (GM2) were found exclusively in the LR fraction (fractions 3 and 4) and were >90 % C18:0 fatty acid, suggesting a neuronal origin. Further analysis also revealed a >threefold increase in the late-endosome marker bis (monoacylglycerol) phosphate (>70 % as C22:6/22:6-BMP) in non-LR fractions 8-12 whereas different forms of the proposed BMP precursor, phosphatidylglycerol (PG) were in both LR and non-LR fractions and were less elevated in MPS3a brain. Thus heparan sulfate-derived oligosaccharide storage is associated with abnormal lipid accumulation in both lysosomal (BMP) and non-lysosomal (GM3 and GM2) compartments.

Dawson G; Fuller M; Helmsley KM; Hopwood JJ

2012-06-01

124

Systemic Models of Local Development  

Directory of Open Access Journals (Sweden)

Full Text Available The paper approaches in a systemic manner the topic of local development, attempting, on one hand, to turn into account the previous contributions from the specialized literature and, on the other hand, to emphasize the specific mechanisms, describing and modelling the behavior of a local development system, underlining its feedback. The basic hypotheses of a systemic model for local development are synthesized in emphasizing three main subsystems, representing three levels of public management. At the same time, a local development system is composed by the convergence of two cybernetic systems, namely an administrative and an economic one, each with specific missions. Consequently, the paper aims a model for an economic-administrative system of local development (SEADL), whose self-regulation mechanisms are based on qualitative assessments, concerning the relevance or usefulness/sustainability of a local development policy as well as quantitative assessments, referring to efficiency or effectiveness. In the end of the paper a case study is presented in details, being achieved in Braila Municipality, valorising SEADL feedback, using assessments based on production factors or Keynesian approaches. The study represents only a framework, a general one for approaching a complex topic, such as local development, and it may be obviously completed and improved.

Ani Matei; Lucica Matei

2007-01-01

125

Morphology of leukocytes from cats affected with alpha-mannosidosis and mucopolysaccharidosis VI (MPS VI).  

Science.gov (United States)

The morphology and ultrastructure of circulating white blood cells from six Persian and from five Russian Blue/Siamese cats deficient in lysosomal activity of alpha-mannosidase and arylsulfatase B, respectively, were studied and compared to cells from corresponding normal and carrier cats. In cats with mannosidosis, light microscopic examination revealed vacuoles in lymphocytes and monocytes, whereas electron microscopic studies demonstrated additional vacuoles in neutrophils, eosinophils, and basophils. In cats with mucopolysaccharidosis VI (MPS VI), vacuoles containing metachromatic granules were observed in lymphocytes, neutrophils, eosinophils, and monocytes. Ultrastructural studies of these cells identified the accumulation of fibrillar material, which often was associated with lamellated membrane structures. PMID:2503918

Alroy, J; Freden, G O; Goyal, V; Raghavan, S S; Schunk, K L

1989-07-01

126

Morphology of leukocytes from cats affected with alpha-mannosidosis and mucopolysaccharidosis VI (MPS VI).  

UK PubMed Central (United Kingdom)

The morphology and ultrastructure of circulating white blood cells from six Persian and from five Russian Blue/Siamese cats deficient in lysosomal activity of alpha-mannosidase and arylsulfatase B, respectively, were studied and compared to cells from corresponding normal and carrier cats. In cats with mannosidosis, light microscopic examination revealed vacuoles in lymphocytes and monocytes, whereas electron microscopic studies demonstrated additional vacuoles in neutrophils, eosinophils, and basophils. In cats with mucopolysaccharidosis VI (MPS VI), vacuoles containing metachromatic granules were observed in lymphocytes, neutrophils, eosinophils, and monocytes. Ultrastructural studies of these cells identified the accumulation of fibrillar material, which often was associated with lamellated membrane structures.

Alroy J; Freden GO; Goyal V; Raghavan SS; Schunk KL

1989-07-01

127

The safety of dipyridamole myocardial perfusion scintigraphy (MPS) in patients with end-stage chronic airways limitations (CAL)  

International Nuclear Information System (INIS)

Full text: Dipyridamole MPS is a well-established investigative technique in the diagnosis and pre-operative risk stratification of patients with possible coronary artery disease. However, there remains a concern of its use in patients with end-stage chronic airways limitations (CAL). Lung volume reduction surgery (LVRS) is a recent therapeutic option for such patients. The options for non-invasive pre-operative cardiac assessment in such patients are limited. This study reviewed the safety of dipyridamole use in such a clinical setting. 20 patients (10M, 10F, mean age 64.8 yrs) were evaluated. None had any history of ischaemic heart disease. Dipyridamole was administered intravenously at a dose of 0.05 mg/kg. Six patients remained asymptomatic throughout the procedure, while none experienced any chest pain. Two patients experienced moderate dyspnoea, which was rapidly relieved with aminophylline (100mg IV) during the recovery phase of the study. Two others developed mild dyspnoea; one settled spontaneously, while the other responded promptly to aminophylline. Aminophylline was administered to nine other patients to reverse minor symptoms (headache, flushing sensation). One other patient developed marked hypotension (SBP fell >20mmHg) and bradycardia, but no ECG changes for myocardial ischaemia. He responded well to aminophylline. His myocardial perfusion scan demonstrated extensive reversible myocardial ischaemia. Although the population size was small, dipyridamole appears safe to use in patients with end-stage CAL. Copyright (2000) The Australian and New Zealand Society of Nuclear Medicine Inc

2000-01-01

128

Development of animation processing system  

Energy Technology Data Exchange (ETDEWEB)

Computer and network environment for image processing has been developed and maintained by the computing and information systems center under the course of establishing a distributed processing environment. A server workstation was introduced for image processing. An animation processing system, in which simulation results are consecutively visualized on the server workstation and automatically recorded on a video tape, has been developed. In this report, a system construction, visualization in the workstation using a visualization tool, control of video tape recorder and workstation, and production of animation video are described with some examples. (author).

Kato, Katsumi [Nuclear Energy Data Center, Tokai, Ibaraki (Japan); Watanabe, Tadashi; Machida, Masahiko; Kaburaki, Hideo

1995-03-01

129

TOPEX electrical power system  

Science.gov (United States)

The TOPEX mission requirements which impact the power requirements and analyses are presented. A description of the electrical power system (EPS), including energy management and battery charging methods that were conceived and developed to meet the identified satellite requirements, is included. Analysis of the TOPEX EPS confirms that all of its electrical performance and reliability requirements have been met. The TOPEX EPS employs the flight-proven modular power system (MPS) which is part of the Multimission Modular Spacecraft and provides high reliability, abbreviated development effort and schedule, and low cost. An energy balance equation, unique to TOPEX, has been derived to confirm that the batteries will be completely recharged following each eclipse, under worst-case conditions. TOPEX uses three NASA Standard 50AH Ni-Cd batteries, each with 22 cells in series. The MPS contains battery charge control and protection based on measurements of battery currents, voltages, temperatures, and computed depth-of-discharge. In case of impending battery depletion, the MPS automatically implements load shedding.

Chetty, P. R. K.; Roufberg, Lew; Costogue, Ernest

130

Pathogenesis of Morquio A syndrome: an autopsied case reveals systemic storage disorder.  

UK PubMed Central (United Kingdom)

Mucopolysaccharidosis IVA (MPS IVA; Morquio A syndrome) is a lysosomal storage disorder caused by deficiency of N-acetylgalactosamine-6-sulfate sulfatase, which results in systemic accumulation of glycosaminoglycans (GAGs), keratan sulfate and chondroitin-6-sulfate. Accumulation of these GAGs causes characteristic features as disproportionate dwarfism associated with skeletal deformities, genu valgum, pigeon chest, joint laxity, and kyphoscoliosis. However, the pathological mechanism of systemic skeletal dysplasia and involvement of other tissues remain unanswered in the paucity of availability of an autopsied case and successive systemic analyses of multiple tissues. We report here a 20-year-old male autopsied case with MPS IVA, who developed characteristic skeletal features by the age of 1.5 years and died of acute respiratory distress syndrome five days later after occipito-C1-C2 cervical fusion. We pathohistologically analyzed postmortem tissues including trachea, lung, thyroid, humerus, aorta, heart, liver, spleen, kidney, testes, bone marrow, and lumbar vertebrae. The postmortem tissues relevant with clinical findings demonstrated 1) systemic storage materials in multiple tissues beyond cartilage, 2) severely vacuolated and ballooned chondrocytes in trachea, humerus, vertebrae, and thyroid cartilage with disorganized extracellular matrix and poor ossification, 3) appearance of foam cells and macrophages in lung, aorta, heart valves, heart muscle, trachea, visceral organs, and bone marrow, and 4) storage of chondrotin-6-sulfate in aorta. This is the first autopsied case with MPS IVA whose multiple tissues have been analyzed pathohistologically and these pathological findings should provide a new insight into pathogenesis of MPS IVA.

Yasuda E; Fushimi K; Suzuki Y; Shimizu K; Takami T; Zustin J; Patel P; Ruhnke K; Shimada T; Boyce B; Kokas T; Barone C; Theroux M; Mackenzie W; Nagel B; Ryerse JS; Orii KE; Iida H; Orii T; Tomatsu S

2013-07-01

131

Pathogenesis of Morquio A syndrome: an autopsied case reveals systemic storage disorder.  

Science.gov (United States)

Mucopolysaccharidosis IVA (MPS IVA; Morquio A syndrome) is a lysosomal storage disorder caused by deficiency of N-acetylgalactosamine-6-sulfate sulfatase, which results in systemic accumulation of glycosaminoglycans (GAGs), keratan sulfate and chondroitin-6-sulfate. Accumulation of these GAGs causes characteristic features as disproportionate dwarfism associated with skeletal deformities, genu valgum, pigeon chest, joint laxity, and kyphoscoliosis. However, the pathological mechanism of systemic skeletal dysplasia and involvement of other tissues remain unanswered in the paucity of availability of an autopsied case and successive systemic analyses of multiple tissues. We report here a 20-year-old male autopsied case with MPS IVA, who developed characteristic skeletal features by the age of 1.5 years and died of acute respiratory distress syndrome five days later after occipito-C1-C2 cervical fusion. We pathohistologically analyzed postmortem tissues including trachea, lung, thyroid, humerus, aorta, heart, liver, spleen, kidney, testes, bone marrow, and lumbar vertebrae. The postmortem tissues relevant with clinical findings demonstrated 1) systemic storage materials in multiple tissues beyond cartilage, 2) severely vacuolated and ballooned chondrocytes in trachea, humerus, vertebrae, and thyroid cartilage with disorganized extracellular matrix and poor ossification, 3) appearance of foam cells and macrophages in lung, aorta, heart valves, heart muscle, trachea, visceral organs, and bone marrow, and 4) storage of chondrotin-6-sulfate in aorta. This is the first autopsied case with MPS IVA whose multiple tissues have been analyzed pathohistologically and these pathological findings should provide a new insight into pathogenesis of MPS IVA. PMID:23683769

Yasuda, Eriko; Fushimi, Kazunari; Suzuki, Yasuyuki; Shimizu, Katsuji; Takami, Tsuyoshi; Zustin, Jozef; Patel, Pravin; Ruhnke, Kristen; Shimada, Tsutomu; Boyce, Bobbie; Kokas, Terry; Barone, Carol; Theroux, Mary; Mackenzie, William; Nagel, Barbara; Ryerse, Jan S; Orii, Kenji E; Iida, Hiroki; Orii, Tadao; Tomatsu, Shunji

2013-04-16

132

Mps1 and Ipl1/Aurora B act sequentially to correctly orient chromosomes on the meiotic spindle of budding yeast.  

UK PubMed Central (United Kingdom)

The conserved kinases Mps1 and Ipl1/Aurora B are critical for enabling chromosomes to attach to microtubules so that partner chromosomes will be segregated correctly from each other, but the precise roles of these kinases have been unclear. We imaged live yeast cells to elucidate the stages of chromosome-microtubule interactions and their regulation by Ipl1 and Mps1 through meiosis I. Ipl1 was found to release kinetochore-microtubule (kMT) associations after meiotic entry, liberating chromosomes to begin homologous pairing. Surprisingly, most chromosome pairs began their spindle interactions with incorrect kMT attachments. Ipl1 released these improper connections, whereas Mps1 triggered the formation of new force-generating microtubule attachments. This microtubule release and reattachment cycle could prevent catastrophic chromosome segregation errors in meiosis.

Meyer RE; Kim S; Obeso D; Straight PD; Winey M; Dawson DS

2013-03-01

133

Mps1 and Ipl1/Aurora B act sequentially to correctly orient chromosomes on the meiotic spindle of budding yeast.  

Science.gov (United States)

The conserved kinases Mps1 and Ipl1/Aurora B are critical for enabling chromosomes to attach to microtubules so that partner chromosomes will be segregated correctly from each other, but the precise roles of these kinases have been unclear. We imaged live yeast cells to elucidate the stages of chromosome-microtubule interactions and their regulation by Ipl1 and Mps1 through meiosis I. Ipl1 was found to release kinetochore-microtubule (kMT) associations after meiotic entry, liberating chromosomes to begin homologous pairing. Surprisingly, most chromosome pairs began their spindle interactions with incorrect kMT attachments. Ipl1 released these improper connections, whereas Mps1 triggered the formation of new force-generating microtubule attachments. This microtubule release and reattachment cycle could prevent catastrophic chromosome segregation errors in meiosis. PMID:23371552

Meyer, Régis E; Kim, Seoyoung; Obeso, David; Straight, Paul D; Winey, Mark; Dawson, Dean S

2013-01-31

134

Development of maintenance engineering system  

International Nuclear Information System (INIS)

Department of JMTR project has developed the Maintenance Engineering System which evaluates the aging tendency of the facilities. The system is used for the repair plan and the replace period of parts, components, equipments or facilities. The system has the data-base which consists of the check data, the inspection data, the trouble data and the repair data at the JMTR since the virgin criticality. The system is utilized maintenance works and concludes the maintenance procedures for the failure components, equipments and facilities. This system has the following characteristics. (1) Anybody can operate the system as easily as word processor. (2) Data are put into by man-machine-interface. (3) The data sheets are with light color and the recognizable arrangements. (4) The system is cost-efficient using commercial personal computers and applications. The research card and the layouts of the input data sheet had been formatted. Data has been begun to be put into the system and to check its functions. The result demonstrates that the system is available for preventive maintenance at the JMTR. (author)

1995-01-01

135

Heating Systems Course Development Model  

Science.gov (United States)

The Advanced Technology Environmental and Energy Center (ATEEC) has provided this course development model on heating systems, including gas, fuel oil, and electric furnaces, and heat pumps. Energy conservation, efficiency options and environmental impacts are also covered. Users must download this resource for viewing, which requires a free log-in. There is no cost to download the item.

2011-05-18

136

Automotive Stirling Engine systems development  

Energy Technology Data Exchange (ETDEWEB)

The objective of the Automotive Stirling Engine (ASE) program is to develop a Stirling engine for automotive use that provides a 30% improvement in fuel economy relative to a comparable internal-combustion engine while meeting emissions goals. This paper traces the engine systems' development efforts focusing on: 1) a summary of engine system performance for all Mod I engines; 2) the development program conducted for the upgraded Mod I; and 3) vehicle systems work conducted to enhance vehicle fuel economy. Problems encountered during the upgraded Mod I test program are discussed. The importance of the EPA driving cycle cold-start penalty and the measures taken to minimize that penalty with the Mod II are also addressed. The design of an engine intended to meet the program objectives (Mod II) was initiated based on the Reference Engine System Design (RESD)*, which is a departure from existing program engines in that it is a Vee design with an annular regenerator/cooler arrangement, as opposed to the existing U-cannister configuration. The development is expected to take place over an approximate four-year time period, culminating in a vehicle demonstration of fuel economy that meets program goals. This paper presents the performance development of the ASE Program engines. Results obtained with the initial P-40 engines are presented, and Mod I engine performance and vehicle fuel economy measurements are discussed. The actions taken on the upgraded Mod I program are detailed, and the results presented. The Mod II engine design is reviewed, and projections for that system are presented. Accomplishments achieved within the ASE Program since its inception are also summarized.

Richey, A.E.

1984-08-01

137

Mobile munitions assessment system development  

Energy Technology Data Exchange (ETDEWEB)

The United States has been involved in the development, testing, storage and disposal of chemical weapons since World War I. As a result, there are numerous sites which contain the presence of chemical warfare materiel. This materiel is in the form of buried surplus munitions, munitions that did not detonate during testing and other forms. These items pose a significant human health and environmental hazard and must be disposed of properly. The US Army was tasked by the Department of Defense with the remediation of all non-stockpile chemical warfare materiel. To help comply with this tasking, the Army Project Manager for Nonstockpile Chemical Materiel is sponsoring the development of a Mobile Munitions Assessment System (MMAS). The system is being developed by the Idaho National Engineering Laboratory and Dugway Proving Ground. The purpose of the system is to inspect suspect munitions and containers, identify the fill, evaluate the fuzing and firing train and analyze samples from the surrounding area to determine if chemical warfare materiel is present. The information gained from the application of the MMAS and other systems is intended to be used to establish the best method to handle and dispose of a given munition and its contents.

Rowe, L.C. [Department of the Army, Aberdeen Proving Ground, MD (United States); Watts, K.D. [Lockheed Idaho Technologies Co., Idaho Falls, ID (United States); Jorgensen, C.L. [Dugway Proving Ground, UT (United States)

1996-05-01

138

The Micro-Pillar Shear-Stress Sensor MPS3 for Turbulent Flow  

Directory of Open Access Journals (Sweden)

Full Text Available Wall-shear stress results from the relative motion of a fluid over a body surface as a consequence of the no-slip condition of the fluid in the vicinity of the wall. To determine the two-dimensional wall-shear stress distribution is of utter importance in theoretical and applied turbulence research. In this article, characteristics of the Micro-Pillar Shear-Stress Sensor MPS3, which has been shown to offer the potential to measure the two-directional dynamic wall-shear stress distribution in turbulent flows, will be summarized. After a brief general description of the sensor concept, material characteristics, possible sensor-structure related error sources, various sensitivity and distinct sensor performance aspects will be addressed. Especially, pressure-sensitivity related aspects will be discussed. This discussion will serve as ‘design rules’ for possible new fields of applications of the sensor technology.

Sebastian Große; Wolfgang Schröder

2009-01-01

139

Social networks, politics and Commitment 2.0: Spanish MPs on Facebook  

Directory of Open Access Journals (Sweden)

Full Text Available In a technologically and sociologically advanced society, the organizations that do not use the new media and the cyber communication techniques are probably doomed to failure. In this virtual sphere the social networks constitute a suitable resource and channel for the implementation of political marketing 2.0, as it provides a scenario where the interaction with users is possible. From this perspective, we verified their presence of the 350 members of the Spanish Congress on Facebook, the country’s most popular social network, in order to establish the predominant typologies, updating frequency, contents, resources, and the types of information posted in this spaces.This article also examines the interactivity of MPs in what we have termed Commitment 2.0: political communication in personal contexts such as social networks requires going from the participatory attitude to the participatory action; that is, to accept the interaction 2.0 as the correct behaviour on the network.

Miguel Túñez, Ph.D.; José Sixto, B.A.

2011-01-01

140

Development of economic collector systems  

Energy Technology Data Exchange (ETDEWEB)

A comparison of systems of the different modular concepts was introduced for collector development work. The HELIOMAN-3-32/A collector module was used as the basis of comparison. Because of the results of this comparison, the single axis/horizontal north-south variant was given preference for development work. Activities for the design and development of the following components for the single axis horizontal trough following the sun took place: Parabolic mirror (1.5 m long, 1.1 m wide, thickness of glass 5 mm), absorber (38 mm diameter), trough structure (combination of several rows of mirrors), trough drive with 4 joint drive. Apart from this development work for a cylindrical paraboloid collector, the complete unit of a collector area was also considered (reducing the price).

Kraft, M.

1983-01-01

 
 
 
 
141

Development of teleoperated cleanup system  

International Nuclear Information System (INIS)

[en] This report describes the development of a teleoperated cleanup system for use in a highly radioactive environment of DFDF(DUPIC Fuel Demonstration Facility) at KAERI where direct human access to the in-cell is strictly limited. The teleoperated cleanup system was designed to remotely remove contaminants placed or fixed on the floor surface of the hot-cell by mopping them with wet cloth. This cleanup system consists of a mopping slave, a mopping master and a control console. The mopping slave located at the in-cell comprises a mopping tool with a mopping cloth and a mobile platform, which were constructed in modules to facilitate maintenance. The mopping master that is an input device to control the mopping slave has kinematic dissimilarity with the mopping slave. The control console provides a means of bilateral control flows and communications between the mopping master and the mopping slave. In operation, the human operator from the out-of-cell performs a series of decontamination tasks remotely by manipulating the mopping slave located in-cell via a mopping master, having a sense of real mopping. The environmental and mechanical design considerations, and control systems of the developed teleoperated cleanup system are also described

2005-01-01

142

Developing performance-appraisal systems.  

UK PubMed Central (United Kingdom)

The development and applications of performance-appraisal systems for hospital pharmacy personnel are discussed. The need for a performance-appraisal system is explained from the perspectives of the employee, the manager, and the hospital. Ethical standards that should be considered by managers during the appraisal process are listed. Performance standards are a key component of a performance-appraisal system and should be developed jointly by management and staff. Types of appraisal methods, personnel who should conduct appraisals, and the frequency at which appraisals should be conducted are discussed. Potential biases in appraisal methods and the preparation for and conduct of employee appraisals are discussed. A performance-appraisal system should be designed to meet the needs of employees, managers, and the hospital. Such a system will be more effective if it ensures the regular, frequent flow of data on employee performance, the systematic comparison of these data with previously agreed-upon expectations, and the frequent reporting of the results of these comparisons to both employees and managers.

Ross SR

1984-08-01

143

Nanosatellite electrical power system development  

Science.gov (United States)

Nanosatellites have the potential to carry out the complex work of today's larger satellites at a fraction of the cost. Their small designs drastically reduce launch costs and allow many research projects and technology demonstration missions to be flown. The development of small satellites has created a need for smaller, lightweight electrical power systems (EPS) without compromising the power capacity. This thesis focuses on the electrical power system of the YUsend-1 mission. The work carried out in designing and developing the EPS for the YUsend mission utilizing commercial technologies is outlined. Mission modes are developed and a power budget is assigned for the different subsystems setting a baseline for how much power is needed. Different battery chemistries are analyzed in order to find a type that would suit the needs of the YUsend program. Commercially available batteries are put through space environment testing and the results are presented. The fabrication, testing, and space qualification results of solar panels using Triangular Advanced Solar Cells (TASCs) are also presented. Lastly the layout for the distribution board is developed.

Navarathinam, Nimal

144

KSTAR RF heating system development  

International Nuclear Information System (INIS)

Design, high-voltage test, and installation of 6 MW ICRF heating system for KSTAR is completed. The antenna demonstrated satisfactory standoff at high voltages up to 41 kV for 300 sec. The result indicates good power handling capabilities of the antenna as high as 10 MW/m2. This power density is equivalent to RF power coupling of 6 MW into a 4 ?/m target plasma, and is typical of advanced tokamak heating scenarios. In addition, vacuum feed through, DC break, and liquid stub developed for 300 sec operation are installed, as well as a 2 MW, 30-60MHz transmitter. The transmitter successfully produced output powers of 600 kW continuously, 1.5?1.8 MW for 300 sec, and 2 MW for 100 msec or shorter pulses. A realtime control system based on DSP and EPICS is developed, installed, and tested on the ICRF system. Initial results from feasibility study indicate that the present antenna and the transmission lines could allow load-resilient operation on KSTAR. Until the KSTAR tokamak start to produce plasmas in 2008, however, hands-on operational experiences are obtained from participating in ICRF heating experiments at ASDEX and DIII-D tokamaks arranged through international cooperation.

2007-01-01

145

KSTAR RF heating system development  

Energy Technology Data Exchange (ETDEWEB)

Design, high-voltage test, and installation of 6 MW ICRF heating system for KSTAR is completed. The antenna demonstrated satisfactory standoff at high voltages up to 41 kV for 300 sec. The result indicates good power handling capabilities of the antenna as high as 10 MW/m2. This power density is equivalent to RF power coupling of 6 MW into a 4 {omega}/m target plasma, and is typical of advanced tokamak heating scenarios. In addition, vacuum feed through, DC break, and liquid stub developed for 300 sec operation are installed, as well as a 2 MW, 30-60MHz transmitter. The transmitter successfully produced output powers of 600 kW continuously, 1.5{approx}1.8 MW for 300 sec, and 2 MW for 100 msec or shorter pulses. A realtime control system based on DSP and EPICS is developed, installed, and tested on the ICRF system. Initial results from feasibility study indicate that the present antenna and the transmission lines could allow load-resilient operation on KSTAR. Until the KSTAR tokamak start to produce plasmas in 2008, however, hands-on operational experiences are obtained from participating in ICRF heating experiments at ASDEX and DIII-D tokamaks arranged through international cooperation.

Kwak, J. G.; Kim, S. K.; Hwang, C. K. (and others)

2007-10-15

146

Description, operation, and maintenance information on joystick and closed-circuit television MPS-36 radar, Meppen Range, Federal Republic of Germany  

Energy Technology Data Exchange (ETDEWEB)

Personnel from Stockpile Evaluation Program Division I, 7261, have been testing Joint Test Assemblies (JTAs) at Meppen Range, Federal Republic of Germany (FRG) since 1984. JTA trajectories were obtained from cinetheodolite film. The MPS-36 radar at Meppen Range is required to track the aircraft before bomb release to verify the release parameters for range safety and for the bomb trajectory after release. This is a difficult task because of the low-level approach of the aircraft. Division 7261 personnel asked Tonopah Test Range Department 7170 to assist in solving radar tracking problems. We recommended a new closed-circuit television system with a zoom lens and a force-operated, two-axis joystick. This system provides the operator a means of overriding the automode of the radar and manually positioning the radar antenna in azimuth (AZ) and elevation (EL). The joystick operator keeps the target (aircraft or bomb) centered in the TV picture by applying the correct pressure to the joystick. At the same time, the radar console operator maintains automatic range tracking by assisting the range gate through ground clutter using the control level of the range gate, as a rate-aid control in automatic mode. During the period May 8-17, 1989, the visual tracking equipment was installed in the Meppen radar. On May 16, 1989 a bomb dummy unit, loft maneuver was tracked successfully. The video, with time of day, was recorded for posttest, quick-look data. In the ten years of planned testing, a twenty-fold cost savings would be achieved with incorporation of the visual tracking capability to the MPS-36 radar, rather than providing radar beacons on each JTA. 8 figs.

Arndt, C.E.

1990-02-01

147

The Simulator of the Timing and Magnitude of Pollen Season (STaMPS) model: a pollen production model for regional emission and transport modeling  

Directory of Open Access Journals (Sweden)

Full Text Available A pollen model that simulates the timing and production of wind-dispersed allergenic pollen by terrestrial, temperate vegetation has been developed to quantify how pollen occurrence may be affected by climate change and to investigate how pollen can interact with anthropogenic pollutants to affect human health. The Simulator of the Timing and Magnitude of Pollen Season (STaMPS) model is driven by local meteorological conditions and is designed to be sensitive to climate shifts, as well as flexible with respect to the vegetation species and plant functional types (trees, grasses, etc.) represented and the climate zones simulated. The initial focus for the model is the simulation of the pollen emission potential of important allergenic tree and grass species that typically flower between March–June in Southern California (S. CA), which is characterized by moderate Mediterranean and oceanic climate zones as well as regions of arid desert and arid steppe. Vegetation cover and species composition data are obtained from numerous datasets and a database of allergenic vegetation species, their pollen production potential and relative allergenicities has been developed. For the selected allergenic species and spring-early summer simulation period, temperature is the main driver controlling the timing of pollen release, while precipitation (and temperature, for some species) controls the magnitude of pollen produced. The model provides species-specific pollen potential maps for each day of the simulation period; these are then used by a pollen transport model to simulate ambient pollen concentrations as described in a companion paper (Zhang et al., 2013a), which also presents model evaluation results for the S. CA model domain. The STaMPS model was also used to quantify the possible impact of climate change on pollen season under the IPCC SRES A1B scenario as simulated by the ECHAM5 global climate model. Current (1995–2004) and future (2045–2054) meteorological conditions downscaled using the Weather Research and Forecasting (WRF) model were used to drive STaMPS and generate estimates of the relative magnitude and timing of pollen season for important allergenic tree and grass species that bloom from March through June in a larger domain that covers all of CA and Nevada. Differences in the simulated timing and magnitude of pollen season for the selected allergenic species under current and future climate scenarios are presented. The results suggest that across all of the simulated species, pollen season starts an average of 5–6 days earlier under predicted future climatic conditions with an associated average annual domain-wide temperature increase of about 1°C compared to simulated current conditions. Differences in the amount of pollen produced under the two scenarios vary by species and are affected by the selected simulation period (1 March–30 June). Uncertainties associated with the STaMPS model and future model development plans are also discussed.

T. R. Duhl; R. Zhang; A. Guenther; S. H. Chung; M. T. Salam; J. M. House; R. C. Flagan; E. L. Avol; F. D. Gilliland; B. K. Lamb; T. M. VanReken; Y. Zhang; E. Salathé

2013-01-01

148

The Simulator of the Timing and Magnitude of Pollen Season (STaMPS) model: a pollen production model for regional emission and transport modeling  

Science.gov (United States)

A pollen model that simulates the timing and production of wind-dispersed allergenic pollen by terrestrial, temperate vegetation has been developed to quantify how pollen occurrence may be affected by climate change and to investigate how pollen can interact with anthropogenic pollutants to affect human health. The Simulator of the Timing and Magnitude of Pollen Season (STaMPS) model is driven by local meteorological conditions and is designed to be sensitive to climate shifts, as well as flexible with respect to the vegetation species and plant functional types (trees, grasses, etc.) represented and the climate zones simulated. The initial focus for the model is the simulation of the pollen emission potential of important allergenic tree and grass species that typically flower between March-June in Southern California (S. CA), which is characterized by moderate Mediterranean and oceanic climate zones as well as regions of arid desert and arid steppe. Vegetation cover and species composition data are obtained from numerous datasets and a database of allergenic vegetation species, their pollen production potential and relative allergenicities has been developed. For the selected allergenic species and spring-early summer simulation period, temperature is the main driver controlling the timing of pollen release, while precipitation (and temperature, for some species) controls the magnitude of pollen produced. The model provides species-specific pollen potential maps for each day of the simulation period; these are then used by a pollen transport model to simulate ambient pollen concentrations as described in a companion paper (Zhang et al., 2013a), which also presents model evaluation results for the S. CA model domain. The STaMPS model was also used to quantify the possible impact of climate change on pollen season under the IPCC SRES A1B scenario as simulated by the ECHAM5 global climate model. Current (1995-2004) and future (2045-2054) meteorological conditions downscaled using the Weather Research and Forecasting (WRF) model were used to drive STaMPS and generate estimates of the relative magnitude and timing of pollen season for important allergenic tree and grass species that bloom from March through June in a larger domain that covers all of CA and Nevada. Differences in the simulated timing and magnitude of pollen season for the selected allergenic species under current and future climate scenarios are presented. The results suggest that across all of the simulated species, pollen season starts an average of 5-6 days earlier under predicted future climatic conditions with an associated average annual domain-wide temperature increase of about 1°C compared to simulated current conditions. Differences in the amount of pollen produced under the two scenarios vary by species and are affected by the selected simulation period (1 March-30 June). Uncertainties associated with the STaMPS model and future model development plans are also discussed.

Duhl, T. R.; Zhang, R.; Guenther, A.; Chung, S. H.; Salam, M. T.; House, J. M.; Flagan, R. C.; Avol, E. L.; Gilliland, F. D.; Lamb, B. K.; VanReken, T. M.; Zhang, Y.; Salathé, E.

2013-04-01

149

Computer aided training system development  

Energy Technology Data Exchange (ETDEWEB)

The first three phases of Training System Development (TSD) -- job and task analysis, curriculum design, and training material development -- are time consuming and labor intensive. The use of personal computers with a combination of commercial and custom-designed software resulted in a significant reduction in the man-hours required to complete these phases for a Health Physics Technician Training Program at a nuclear power station. This paper reports that each step in the training program project involved the use of personal computers: job survey data were compiled with a statistical package, task analysis was performed with custom software designed to interface with a commercial database management program. Job Performance Measures (tests) were generated by a custom program from data in the task analysis database, and training materials were drafted, edited, and produced using commercial word processing software.

Midkiff, G.N. (Advanced Technology Engineering Systems, Inc., Savannah, GA (US))

1987-01-01

150

Common Rail Injection System Development  

Energy Technology Data Exchange (ETDEWEB)

The collaborative research program between the Department of energy and Electro-Motive Diesels, Inc. on the development of common rail fuel injection system for locomotive diesel engines that can meet US EPA Tier 2 exhaust emissions has been completed. This final report summarizes the objectives of the program, work scope, key accomplishments and research findings. The major objectives of this project encompassed identification of appropriate injection strategies by using advanced analytical tools, development of required prototype hardware/controls, investigations of fuel spray characteristics including cavitation phenomena, and validation of hareware using a single-cylinder research locomotive diesel engine. Major milestones included: (1) a detailed modeling study using advanced mathematical models - several various injection profiles that show simultaneous reduction of NOx and particulates on a four stroke-cycle locomotive diesel engine were identified; (2) development of new common rail fuel injection hardware capable of providing these injection profiles while meeting EMD engine and injection performance specifications. This hardware was developed together with EMD's current fuel injection component supplier. (3) Analysis of fuel spray characteristics. Fuel spray numerical studies and high speed photographic imaging analyses were performed. (4) Validation of new hardware and fuel injection profiles. EMD's single-cylinder research diesel engine located at Argonne National Laboratory was used to confirm emissions and performacne predictions. These analytical ane experimental investigations resulted in optimized fuel injection profiles and engine operating conditions that yield reductions in NOx emissions from 7.8 g/bhp-hr to 5.0 g/bhp-hr at full (rated) load. Additionally, hydrocarbon and particulate emissions were reduced considerably when compared to baseline Tier I levels. The most significant finding from the injection optimization process was a 2% to 3% improvement in fuel economy over EMD's traditional Tier I engine hardware configuration. the common rail fuel injection system enabled this added benefit by virtue of an inherent capability to provide multiple injections per power stroke at high fuel rail pressures. On the basis of the findings in this study, EMD concludes that the new electronically-controlled high-pressure common rail injection system has the potential to meet locomotive Tier 2 NOx and particulates emission standards without sacrificing the fuel economy. A number of areas to further improve the injection hardware and engine operating characteristics to further exploit the benefits of common rail injection system have also been identified.

Electro-Motive,

2005-12-30

151

AGING SYSTEM DESIGN DEVELOPMENT STRATEGY  

Energy Technology Data Exchange (ETDEWEB)

This plan provides an overview, work to date, and the path forward for the design development strategy of the Aging cask for aging commercial spent nuclear fuel (CSNF) at the Yucca Mountain Project (YMP) repository site. Waste for subsurface emplacement at the repository includes US Department of Energy (DOE) high-level radioactive waste (HLW), DOE SNF, commercial fuel in dual-purpose canisters (DPCs), uncanistered bare fuel, naval fuel, and other waste types. Table 1-1 lists the types of radioactive materials that may be aged at YMP, and those materials that will not be placed in an aging cask or module. This plan presents the strategy for design development of the Aging system. The Aging system will not handle naval fuel, DOE HLW, MCOs, or DOE SNF since those materials will be delivered to the repository in a state and sequence that allows them to be placed into waste packages for emplacement. Some CSNF from nuclear reactors, especially CSNF that is thermally too hot for emplacement underground, will need to be aged at the repository.

J. Beesley

2005-02-07

152

ADASAGE, ADA Application Development System  

International Nuclear Information System (INIS)

[en] 1 - Description of program or function: ADASAGE is an application development system designed to facilitate rapid and professional construction of applications written in Ada on microcomputers. ADASAGE applications may vary in size from small to large multi-program systems. ADASAGE consists of a collection of re-usable libraries for database management and form and report processing utilities having the following capabilities: basic universal type and function definitions; sequential file input/output; terminal and file input/output; DOS system command execution; data movement and fill; string manipulation; math libraries; bit manipulation; a relational database utility; data validation; menu form and window procedures; report generation; sort/merge, time, and date functions; sound production; editing; and index rebuilding. Each of the capabilities is integrated to allow the development of an efficient system. As an application is designed and developed, the desired ADASAGE capabilities are chosen and included along with any requirements unique to that application. 2 - Method of solution: All ADASAGE applications which use the database, forms (windows, menus, etc.), or reporting functions require a file with a suffix of .DFL. This file contains the database schema, the various forms and windows, and report definitions. The THOR editor is used to create and maintain the .DFL file. This editor operates on a file with the suffix .SRC and creates and edits schemes, forms, and report formats and compile the .SRC file into the .DFL file used by the application. The application will have unique requirements not satisfied by the selected utilities of ADASAGE. The code for these along with the code necessary to import and use the selected ADASAGE utilities constitutes the programmed application. The completed application system will contain the .DFL file produced by the THOR editor, the required ADASAGE utilities, and the programmed application. During the course of normal database development and use, restructuring and/or rebuilding of database files may be required if the schema for a record is modified (new fields are added, changed, or deleted and new keys selected, etc.), or if the index file for a relation becomes damaged or is destroyed. Program REBUILD performs this task. The rebuilding process is invoked by supplying both an old .DFL file name identifying the schema definition under which the current data was written and a current .DFL file name identifying the new schema definition to which the current database must be changed. REBUILD compares the old and current schema definitions for a relation, adjusts the database files accordingly, and re-tags the database files with the new version so that access with the new schema is allowed. The index file for the relation is then rebuilt, and any unused space within the database files removed. 3 - Restrictions on the complexity of the problem: Maxima for each ADASAGE database are: 4,294,967,000 records (tuples) per record size; 32,000 bytes record (tuple) size; 32,000 fixed-length field (attribute size); 4,294,967,000 variable-length field (attribute) size; 1,000 relations (flat files); 1,000 joined relations; 1,000 views; 500 fields (attributes) per relation; 500 keyed fields per relation; 6,550 forms (windows); 55 significant digits in a number. The user's operating system or hardware may have more stringent limits than these

2001-01-01

153

Cardiac Ultrasound Findings in Infants with Severe (Hurler Phenotype) Untreated Mucopolysaccharidosis (MPS) Type I.  

UK PubMed Central (United Kingdom)

Background: Serious cardiac valve disease and left ventricular hypertrophy occur in most untreated older children with severe mucopolysaccharidosis type I. Although it is assumed that early intervention prevents these processes, evaluation of cardiac findings in these infants has not yet been reported. Methods: We reviewed echocardiograms of 13 untreated infants < 1 year of age with severe mucopolysaccharidosis type I who had undergone evaluation for hematopoietic cell transplantation. We recorded left ventricular chamber dimensions, septal and posterior wall thicknesses, ventricular function, and aortic sinus diameters. We evaluated mitral and aortic valves for increased thickness, regurgitation, and stenosis. Results: Average age (7M, 6F) was 221 (range 25-347) days. Left ventricular chamber dimension was ?2 SD of normal in 3/13; wall thicknesses were ?2 SD of normal in 2/13 infants. Systolic function was normal. Mitral valves were thickened in all infants; mitral regurgitation was present in 9/13, but significant in only three infants. Aortic valves were thickened in 10/13, but no infant had significant aortic regurgitation. Neither mitral nor aortic stenosis occurred. Aortic roots were dilated to ?2 SD of normal in 5/13. Conclusions: Characteristic cardiac features of severe mucopolysaccharidosis type I can be seen in infancy. Mitral and aortic valve thickening are nearly universally present, even in the youngest infants. In 20-30 % of infants, other abnormalities such as left ventricular dilation, increased wall thickness, and mild mitral/aortic regurgitation may occur. Aortic root dilation is a frequent finding. Early intervention with enzyme replacement therapy may minimize the incidence and severity of cardiac findings in these infants. Summary: Serious cardiac valve disease and left ventricular hypertrophy occur in most untreated older children with severe mucopolysaccharidosis type I. Although it is assumed that early intervention prevents these processes, evaluation of cardiac findings in these infants has not yet been reported. In our study of 13 infants with severe untreated MPS I < 1 year of age, mitral and aortic valve thickening was nearly universally present and aortic root dilation was frequent. Despite this, we found a lower incidence of left ventricular hypertrophy and both a lower incidence and milder expression of mitral and aortic valve dysfunction than previously reported in older children. These findings suggest that earlier intervention, including neonatal screening, may be of benefit to children with severe MPS I.

Schroeder L; Orchard P; Whitley CB; Berry JM; Tolar J; Miller W; Braunlin EA

2013-01-01

154

Development of vertical lift systems  

Energy Technology Data Exchange (ETDEWEB)

A description is presented of development of vertical mining shaft transport in KOMAG (Design and technology center for mining equipment) in Poland: 1) pitting hoisting equipment (power - up to 500 kW, manuf. by ZGODA; 2) driving hoist equipment (development proceeded from the first pieces of equipment for open pit operations, such as type VV-3000 models, 290 and 400 kW to machines like VOV-5500 at 630 kW, to modern machines like V-5000 with 2x1000 kW, including export models; in the near future 2400 kW model V 4500 machines without reductors will be use, having a thyristor transformer/direct current motor; 3) underground hoist units that are explosion-safe (the most recent model - 2-33000 MH with a haulage of 60 kH, 2x80 kW, manuf. by RYFAMA plant); 4) mine shaft hoist machinery with asynchronous feed (power range - from 500 to 2000 kW; two-cable and four-cable hoist models have been built - WL 2/4500/2x630 and WL 4/3200/2x630; new dynamic braking systems have been developed; also ones with electro-pneumatic regulators that provide smoothness in changes of the braking torque; 5) control and safety devices for the hoist machinery (including programs controlling runs of hoist equipment, automatic control devices for cable slippage along the pulleys, and controls for ''pull-up'' of the hoist vessel; 6) speciasl lift devices - model V-1500A and V-1100A for carrying out inspections and maintenance operations in shafts; 7) auxiliary devices for performing transport and loading operations in the shaft area. Important directions in KOMAG research include optimization of kinematic parameters and dynamics of mining hoist systems, standardization of elevator machinery and studying their reliability.

Zmyslowski, T.

1980-01-01

155

Cloning and characterization of a gene, mpsA, encoding a protein associated with intracellular magnetic particles from Magnetospirillum sp. strain AMB-1.  

UK PubMed Central (United Kingdom)

Proteins located within the lipid bilayer, surrounding the intracellular bacterial magnetic particles (BMP) from Magnetospirillum sp. AMB-1, were separated using SDS-PAGE. Several major proteins of approximate molecular weight 66.2, 35.6, and 24.8 kDa were identified. The N-terminal amino acid sequence of one of these proteins, designated MpsA, was determined and used to design a pair of PCR primers which amplified a 105 bp DNA fragment from AMB-1 genomic DNA. Gene-walking, using anchored PCR, was used to determine the complete nucleotide sequence (954 bp) of the mpsA gene. The mpsA encodes a 317 amino acid protein which does not have an N-terminal cytoplasmic transport signal sequence. Intracellular localization studies were carried out using an mpsA-luc gene fusion expressed in AMB-1 following gene transfer by conjugation. The gene fusion was constructed by cloning a 1.6 kb mpsA fragment upstream of luc in the conjugal plasmid pKLC. The MpsA-Luc fusion protein was preferentially located on the magnetic particle membrane. Although the function of MpsA remains unknown, homology searches suggest similarity with the alpha subunit of acetyl-CoA carboxylase and the CoA-binding motif.

Matsunaga T; Tsujimura N; Okamura Y; Takeyama H

2000-02-01

156

Cloning and characterization of a gene, mpsA, encoding a protein associated with intracellular magnetic particles from Magnetospirillum sp. strain AMB-1.  

Science.gov (United States)

Proteins located within the lipid bilayer, surrounding the intracellular bacterial magnetic particles (BMP) from Magnetospirillum sp. AMB-1, were separated using SDS-PAGE. Several major proteins of approximate molecular weight 66.2, 35.6, and 24.8 kDa were identified. The N-terminal amino acid sequence of one of these proteins, designated MpsA, was determined and used to design a pair of PCR primers which amplified a 105 bp DNA fragment from AMB-1 genomic DNA. Gene-walking, using anchored PCR, was used to determine the complete nucleotide sequence (954 bp) of the mpsA gene. The mpsA encodes a 317 amino acid protein which does not have an N-terminal cytoplasmic transport signal sequence. Intracellular localization studies were carried out using an mpsA-luc gene fusion expressed in AMB-1 following gene transfer by conjugation. The gene fusion was constructed by cloning a 1.6 kb mpsA fragment upstream of luc in the conjugal plasmid pKLC. The MpsA-Luc fusion protein was preferentially located on the magnetic particle membrane. Although the function of MpsA remains unknown, homology searches suggest similarity with the alpha subunit of acetyl-CoA carboxylase and the CoA-binding motif. PMID:10679308

Matsunaga, T; Tsujimura, N; Okamura, Y; Takeyama, H

2000-02-24

157

A TPR domain-containing N-terminal module of MPS1 is required for its kinetochore localization by Aurora B.  

UK PubMed Central (United Kingdom)

The mitotic checkpoint ensures correct chromosome segregation by delaying cell cycle progression until all kinetochores have attached to the mitotic spindle. In this paper, we show that the mitotic checkpoint kinase MPS1 contains an N-terminal localization module, organized in an N-terminal extension (NTE) and a tetratricopeptide repeat (TPR) domain, for which we have determined the crystal structure. Although the module was necessary for kinetochore localization of MPS1 and essential for the mitotic checkpoint, the predominant kinetochore binding activity resided within the NTE. MPS1 localization further required HEC1 and Aurora B activity. We show that MPS1 localization to kinetochores depended on the calponin homology domain of HEC1 but not on Aurora B-dependent phosphorylation of the HEC1 tail. Rather, the TPR domain was the critical mediator of Aurora B control over MPS1 localization, as its deletion rendered MPS1 localization insensitive to Aurora B inhibition. These data are consistent with a model in which Aurora B activity relieves a TPR-dependent inhibitory constraint on MPS1 localization.

Nijenhuis W; von Castelmur E; Littler D; De Marco V; Tromer E; Vleugel M; van Osch MH; Snel B; Perrakis A; Kops GJ

2013-04-01

158

Common N-acetylgalactosamine-6-sulfate sulfatase (GALNS) exon mutations in Brazilian patients with mucopolysaccharidosis IVA (MPS IVA)  

Directory of Open Access Journals (Sweden)

Full Text Available Morquio A Syndrome (mucopolysaccharidosis IVA - MPS IVA, OMIM# 253000) is an autosomal recessive inborn error of metabolism caused by the deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS). We investigated five unrelated Brazilian MPS IVA families for mutations in exons 4, 5, 9 and 10 of the GALNS gene. Six out of the 10 mutant alleles were identified. Taken together with a previous study, which included six unrelated families, common mutations among Brazilian patients were p.N164T, p.G116S and p.G301C. Among one hundred control subjects three novel silent mutations were found (p.A107A; GCC -> GCT, p.Y108Y; TAC -> TAT, p.P357P; CCG -> CCA). Screening starting with exons 4, 5, 9, 10 and 11 may be a good strategy for genotyping of Brazilian patients since these exons include 73% of all mutations identified in the current and previous studies.

Tatiana Dieter; Ursula da Silveira Matte; Ida Vanessa Schwartz; Shunji Tomatsu; Roberto Giugliani

2007-01-01

159

Heteroallelic missense mutations of the galactosamine-6-sulfate sulfatase (GALNS) gene in a mild form of Morquio disease (MPS IVA)  

Energy Technology Data Exchange (ETDEWEB)

Morquio disease (MPS IVA) is an autosomal recessive disorder caused by a deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS) activity. Patients commonly present in early infancy with growth failure, spondyloepiphyseal dysplasia, corneal opacification, and keratan sulfaturia, but milder forms have been described. We report on a patient who grew normally until age 5 years. Her keratan sulfaturia was not detected until adolescence, and she now has changes restricted largely to the axial skeleton. She has experienced only mildly impaired vision. At age 22, thin-layer chromatography of purified glycosaminoglycans showed some keratan sulfaturia. GALNS activity in fibroblast homogenate supernatants was 20 {plus_minus} 5% of controls (as compared to 5 {plus_minus} 3% of controls in severe MPS IVA, P <.003). Kinetic analysis of residual fibroblast GALNS activity in patient and parents revealed decreased K{sub m} and increased V{sub max} in the mother and daughter, but not in the father, compatible with compound heterozygosity. GALNS exons were amplified from patient genomic DNA and screened by SSCP. Two missense mutations, a C to T transition at position 335 (predicting R94C) and a T to G transversion at position 344 (predicting F97V), were found on sequencing an abnormally migrating exon 3 amplicon. Digestion of the amplicon with FokI and AccI restriction enzymes (specific for the R94C and F97V mutations, respectively) confirmed heterozygosity. In fibroblast transfection experiments, heterozygous R94C and F97V mutants independently expressed as severe and mile GALNS deficiency, respectively. We interpret these findings to indicate that our patient bears heteroallelic GALNS missense mutations, leading to GALNS deficiency and mild MPS IVA. Our findings expand the clinical and biochemical phenotype of MPS IVA, but full delineation of the genotype-phenotype relationship requires further study of native and transfected mutant cell lines. 30 refs., 4 figs., 3 tabs.

Cole, D.E.C. [Univ. of Toronto, Ontario (Canada); Gordon, B.A.; Rupar, C.A. [Univ. of Western Ontario, London (Canada)] [and others

1996-06-28

160

MEASUREMENT PROCESS OF SOFTWARE DEVELOPMENT PROJECTS FOR SUPPORTING STRATEGIC BUSINESS OBJECTIVES IN SOFTWARE DEVELOPING COMPANIES  

Directory of Open Access Journals (Sweden)

Full Text Available Software developing companies work in a competitive market and are often challenged to make business decisions with impact on competitiveness. Models accessing maturity for software development processes quality, such as CMMI and MPS-BR, comprise process measurements systems (PMS). However, these models are not necessarily suitable to support business decisions, neither to achieve strategic goals. The objective of this work is to analyze how the PMS of software development projects could support business strategies for software developing companies. Results taken from this work show that PMS results from maturity models for software processes can be suited to help evaluating operating capabilities and supporting strategic business decisions.

Sandra Lais Pedroso; Leonardo Rocha de Oliveira

2013-01-01

 
 
 
 
161

Operational requirements for the Remote maintenance Monitoring System (RMMS)  

Science.gov (United States)

This operational requirements document was prepared for use in support of the development and implementation of a Remote Maintenance Monitoring System (RMMS) for the National Airspace System (NAS). Fundamental concepts of RMMS operation and the system description have been previously developed by the Airway Facilities Service (AAF). The information generated by the Remote Monitoring Subsystem (RMS) at the equipment site shall be directly available to the responsible maintenance personnel at their work center. Initially, a Maintenance Processor Subsystem (MPS) will be installed at the ARTCC where communication lines with enroute equipment and major airports presently exist. Future MPSs shall be located at sector offices, or major workcenters. The MPS shall monitor the status of all equipment for a specific geographical area and shall automatically notify the monitoring facilities of the equipment alarms. The monitoring facility shall be alerted of an alarm by both visual and aural signals describing where alarm has occurred, the type of alarm, and which equipment is alarming. The MPS shall serve as the primary collection point, processor, and distribution center for all RMM and Maintenance Management System (MMS) data. The RMMS will remote many routine maintenance functions currently performed at the remote equipment sites and will permit them to be accomplished at any suitably equipped work center.

1984-06-01

162

Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1–C-Mad2 core complex  

Digital Repository Infrastructure Vision for European Research (DRIVER)

To satisfy the mitotic checkpoint and drive chromosome congression, the Mps1 kinase lets go of kinetochores by phosphorylating itself in trans (see also related papers by Maciejowski et al. and Santaguida et al. in this issue).

Hewitt, Laura; Tighe, Anthony; Santaguida, Stefano; White, Anne M.; Jones, Clifford D.; Musacchio, Andrea; Green, Stephen

163

Considering Fabry, but Diagnosing MPS I: Difficulties in the Diagnostic Process.  

UK PubMed Central (United Kingdom)

Introduction: Recent studies have indicated that a proportion of patients with renal failure, left ventricular hypertrophy, or cryptogenic stroke have sequence variants in their aGal A gene (Fabry disease), which has resulted in an increase in diagnostic activities for this disorder. The diagnostic process for lysosomal storage disorders may result in findings of unknown clinical significance. Here we report such an unexpected outcome. Case: A 32-year-old male presented at the emergency department because of a transient ischemic attack. Extensive investigations revealed no cause and an initial diagnosis of cryptogenic stroke was made. Subsequently, aGal A activity was measured in a bloodspot and was shown to be normal, but the activity of alpha-L-iduronidase (IDUA), used as reference enzyme, was unexpectedly low: 0.5 umol/L (ref = 1.7-14.3). A diagnosis of IDUA deficiency, mucopolysaccharidosis type 1S or Scheie disease was considered. IDUA gene analysis revealed two homozygous sequence alterations: a silent sequence change (979C > T) in exon 7 (N297N) and an unknown missense mutation 875A > T (R263W). Physical examination was completely normal, without clinical signs of mucopolysaccharidosis type I (MPS I). Leukocyte IDUA activity was also low: 2.1 nmol/mg prot/h (ref = 14-40 nmol prot/h), but higher than the patient range of <0.1 nmol/mg prot/h. Urinary glycosaminoglycan levels were normal both quantitatively and qualitatively. It was concluded that there was low IDUA activity without clinical symptoms and the diagnosis of mucopolysaccharidosis I was discarded. Conclusion: The diagnostic process for lysosomal storage disorders may result in biochemical abnormalities of unknown clinical significance. Early evaluation by a specialist in inborn errors of metabolism may help to avoid anxiety in patients and unnecessary additional analyses.

Langereis EJ; van den Berg IE; Halley DJ; Poorthuis BJ; Vaz FM; Wokke JH; Linthorst GE

2013-01-01

164

APPROACHING DEVELOPMENT IN LOGISTIC INFORMATION SYSTEMS  

Directory of Open Access Journals (Sweden)

Full Text Available The introduction of technology into modern defence necessitates integrated computerized information systems to render effective and efficient logistic support. Traditional information system development does not ensure attainment of use and time scale requirements in the continuously developing environment of logistics. This paper describes current approaches to the development of logistic information systems.

Louis F Buys

2012-01-01

165

Project management for information system development  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Nowadays, with the development of the information and communication technology, information systems have been developing rapidly. More and more software companies choose to develop the information system to be their main business. They want to increase their business profits by developing the inform...

Zhang, Yang

166

Optimal flow and pressure management in machine perfusion systems for organ preservation.  

UK PubMed Central (United Kingdom)

Intra-organ flow is the most critical parameter in machine-perfused organ preservation systems (MPS). Ultrasonic flow sensors (UFS) are commonly employed in MPS. However, UFS are sensitive to changes in fluid composition and temperature and require recalibration. Novel Coriolis-type mass flow sensors (CFS) may be more suitable for MPS because the measurement technique is not amenable to these factors. The effect of viscosity, colloids, temperature, pressure, and preservation solution on flow measurement accuracy of UFS and CFS was therefore investigated. A CFS-based MPS was built and validated for setpoint stability using porcine kidneys and the ability to reproduce different pressure and flow waveforms. The UFS exhibited a temperature- and preservation solution-dependent overestimation of flow rate compared to the CFS. The CFS deviated minimally from the actual flow rate and did not require recalibration. The CFS-based MPS conformed to the preprogrammed temperature, flow, pressure, and vascular resistance settings during 6-h kidney preservation. The system was also able to accurately reproduce different pressure and flow waveforms. Conclusively, CFS-based MPS are more suitable for organ preservation than UFS-based MPS. Our CFS-based MPS provides a versatile yet robust experimental platform for testing and validating different types of clinical and experimental MPS.

Post IC; Dirkes MC; Heger M; Bezemer R; van 't Leven J; van Gulik TM

2012-12-01

167

Britoil develops drilling information system  

Energy Technology Data Exchange (ETDEWEB)

Britoil plc has recently implemented its own drilling information system and is using it to support drilling operations on the Clyde platform in the North Sea. Data base technology can make a significant impact on the management of drilling operations. The associated retrieval and manipulation facilities allow drilling engineers to use well data more effectively than is possible with a manual filing system. In addition, and perhaps more importantly, the technology enables analytic tools to be fully integrated into the decision making process. The technology is described.

Morrison, J.W.

1988-02-29

168

Effect of high dose, repeated intra-CSF injection of sulphamidase on neuropathology in MPS IIIA mice.  

Science.gov (United States)

Mucopolysaccharidosis type IIIA (MPS IIIA) is an inherited neurodegenerative lysosomal storage disorder characterised by progressive loss of learned skills, sleep disturbance and behavioural problems. Reduced activity of sulphamidase (SGSH; EC 3.10.1.1) results in intracellular accumulation of heparan sulphate (HS), with the brain the primary site of pathology. We have used a naturally-occurring MPS IIIA mouse model to determine the effectiveness of SGSH replacement via the cerebrospinal fluid (CSF) to decrease neuropathology. This is a potential therapeutic option for patients with this disorder. Mice received intra-CSF injections of recombinant human SGSH (30, 50 or 70mug) fortnightly from six-18 weeks of age, and the cumulative effect on neuropathology was examined and quantified. Anti-SGSH antibodies detected in plasma at euthanasia did not appear to impact upon the health of the mice or the experimental outcome, with significant, but region- and dose-dependent reductions in an HS-derived oligosaccharide observed in the brain and spinal cord using tandem mass spectrometry. SGSH infusion reduced the number of storage inclusions observed in the brain when visualised using electron microscopy and this correlated with a significant decrease in the immunohistochemical staining of a lysosomal membrane marker (LIMP-II). Reduced numbers of activated isolectin-B4-positive microglia and GFAP-positive astrocytes were seen in many, but not all, brain regions. Significant reductions in the number of ubiquitin-positive intracellular inclusions were also observed. These outcomes demonstrate the effectiveness of this method of enzyme delivery in reducing the spectrum of neuropathological changes in murine MPS IIIA brain. PMID:18518922

Hemsley, Kim M; Beard, Helen; King, Barbara M; Hopwood, John J

2008-06-02

169

Effect of high dose, repeated intra-CSF injection of sulphamidase on neuropathology in MPS IIIA mice.  

UK PubMed Central (United Kingdom)

Mucopolysaccharidosis type IIIA (MPS IIIA) is an inherited neurodegenerative lysosomal storage disorder characterised by progressive loss of learned skills, sleep disturbance and behavioural problems. Reduced activity of sulphamidase (SGSH; EC 3.10.1.1) results in intracellular accumulation of heparan sulphate (HS), with the brain the primary site of pathology. We have used a naturally-occurring MPS IIIA mouse model to determine the effectiveness of SGSH replacement via the cerebrospinal fluid (CSF) to decrease neuropathology. This is a potential therapeutic option for patients with this disorder. Mice received intra-CSF injections of recombinant human SGSH (30, 50 or 70mug) fortnightly from six-18 weeks of age, and the cumulative effect on neuropathology was examined and quantified. Anti-SGSH antibodies detected in plasma at euthanasia did not appear to impact upon the health of the mice or the experimental outcome, with significant, but region- and dose-dependent reductions in an HS-derived oligosaccharide observed in the brain and spinal cord using tandem mass spectrometry. SGSH infusion reduced the number of storage inclusions observed in the brain when visualised using electron microscopy and this correlated with a significant decrease in the immunohistochemical staining of a lysosomal membrane marker (LIMP-II). Reduced numbers of activated isolectin-B4-positive microglia and GFAP-positive astrocytes were seen in many, but not all, brain regions. Significant reductions in the number of ubiquitin-positive intracellular inclusions were also observed. These outcomes demonstrate the effectiveness of this method of enzyme delivery in reducing the spectrum of neuropathological changes in murine MPS IIIA brain.

Hemsley KM; Beard H; King BM; Hopwood JJ

2008-06-01

170

3-D Simulation of Plunging Jet Penetration into a Denser Liquid Pool by the RD-MPS Method  

International Nuclear Information System (INIS)

We used the rigid body dynamics coupled moving particle semi-implicit (RD-MPS) method to simulate a plunging liquid jet penetrating into a denser liquid pool in two and three dimensions. The simulating phenomenon is related to fuel-coolant interactions (FCI) during severe accidents in nuclear power plants when coolant water is forcedly injected into a melt pool. The simulation results suggested that the coupled model be useful in simulating dynamic interactions of multi-phase incompressible fluids as well as that the 3-D simulation for the plunging jet in a confined geometry predicted better agreement with experimental results than the 2-D simulation did

2012-01-01

171

Developing TRUPACT system impact resistance  

International Nuclear Information System (INIS)

The Transportation Technology Center at Sandia National Laboratories has taken the lead in the development of the TRansUranic PACkage Transporter I (TRUPACT-I) for transporting contact-handled transuranic waste. TRUPACT-I is a Type B package designed for transport by truck and rail. One of the regulatory requirements of a Type B package is that it survive a drop onto a 15.2-cm-dia punch. This paper discusses the development of the puncture resistant panels used in TRUPACT-I. Concepts tested ranged from monolithic steel plates to laminated Kevlar fabric bonded to a steel backing plate. The TRUPACT-I wall design incorporated the laminated Kevlar and stainless steel puncture panel.

1984-09-24

172

Development of Calibration System for Contact Transducer  

International Nuclear Information System (INIS)

In this paper, the calibration system for contact transducer has been developed to improve the reliability of the inspection result of ultrasonic testing on rotors. This system consists of signal processing parts: (oscilloscope, spectrum analyzer, pulser/receiver), standard block, and user interface program. Signal processing for the calibration system was performed quickly with high accuracy. The developed system has been applied to a practical calibration of probe using the non-destructive testing on rotors, and demonstrated high sensitivity and precision

1999-01-01

173

The MAGLEV bogie system and its development  

Energy Technology Data Exchange (ETDEWEB)

A new Japan Railways (JR) MAGLEV vehicle was completed in the spring of this year, and the MAGLEV system is now being assembled and prepared on the Yamanashi test line. The completed vehicle consists of the `conventional MAGLEV bogie system`, with rigidly fitted on-board superconducting magnets (SCM). Meanwhile, the new concept of the `SCM resiliently-mounting method` and its controlling system have been continued to be studied and developed for the `new MAGLEV bogie system` on the Miyazaki test track since 1989. The `resiliently mounted SCM bogie system` is being developed and studied for the purpose of riding comfort in the sidewall levitation MAGLEV system, and valuable data were obtained from running tests on the Miyazaki test track. The bogie system for the second train set on the Yamanashi test line will adopt the `SCM resiliently-mounting method`. In this paper, the development of the JR MAGLEV bogie system and its properties are reported. (orig.)

Seino, Hiroshi [Railway Technical Research Inst., Maglev Systems Development Dept., Vehicle Engineering Div., Tokyo (Japan); Kato, Ken-ichi [Railway Technical Research Inst., Maglev Systems Development Dept., Vehicle Engineering Div., Tokyo (Japan); Oshima, Hiroshi [Central Japan Railway Co., Tokyo (Japan). Linear Express Development Div.; Azakami, Masayoshi [Railway Technical Research Inst., Maglev Systems Development Dept., Vehicle Engineering Div., Tokyo (Japan); Yoshioka, Hiroshi [Maglev Systems Technology Lab., Tokyo (Japan)

1995-12-31

174

Recent Developments on Chaos in Mechanical Systems  

Directory of Open Access Journals (Sweden)

Full Text Available Recent advancements in complexity of mechanical systems have led to the application of chaos theory. In this paper, some recent developments on chaos in mechanical systems are explored. The aim is to bring together researchers from various interests of mechanical systems, exposing them to chaos theory. This exposure gives researchers from the discipline of mechanical systems to find opportunity of cross disciplinary research, which may ultimately lead to novel solutions and understanding of mechanical systems.

Mohammad Sajid

2013-01-01

175

Personnel Launch System Autoland Development Study.  

Science.gov (United States)

The Personnel Launch System (PLS) Autoland Development Study focused on development of the guidance and control system for the approach and landing (A/L) phase and the terminal area energy management (TAEM) phase. In the A/L phase, a straight-in trajector...

J. A. Bossi M. A. Langehough J. C. Tollefson

1991-01-01

176

The development of accelerator mass spectroscopy system  

Energy Technology Data Exchange (ETDEWEB)

Inverse PIXE method was applied to the differentiation of Chlorine 36 and Sulfur 36. The contaminated soil from the USSR nuclear test site was measured. Terminal potential of the tandem accelerator was controlled by GVM. A new AMS system, using time-of flight method is under development. The development of beam buncher and beam chopper for the system is briefly described. (A. Yamamoto)

Mitarai, Shiro; Machida, Atsushi; Iwata, Yasunao; Tsubusaki, Yoshihiro; Tanaka, Katsuhiko; Maeda, Toyokazu; Nakajima, Takao [Kyushu Univ., Fukuoka (Japan)

2001-02-01

177

Development of the stock exchange information system  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The stock exchange represents the key institution for the development of capital market of any country. Thus the information system of every stock exchange must satisfy very strict international standards. The development of these systems is particularly difficult in countries in transition, due to ...

Miladinovi? Radojko

178

Safeguards -Safeguards system development support-  

International Nuclear Information System (INIS)

This project mainly focused to technically support national safeguards inspection which is scheduled in the beginning of 1997. It includes non-destructive assay of nuclear fuels, analysis on inspection and environmental samples, remote monitoring of nuclear activities and its analysis, survey on remote sensing of satellite for safeguards application. Non-destructive assay of nuclear fuels dealt with development on verification of spent fuels with emphasis to fabrication of inspection tools with surveillance and gamma measurement on CANDU spent fuels. For sample analysis, study was carried out on process inspection sample analysis method. In addition to this, ultra low background laboratory was set up to execute environmental and swipe samples and sample treatment techniques including water, soil, plant, et al. were researched. Tritiums which were sampled around power plants were analysed. With cooperation of Satellite Technology Research Center of KAIST, use of civilian satellite imagery was surveyed. To train facility operators for safeguards, various technology on non-destructive assay was lectured to personnel of Korea Electric Power Corporation. And to enhance out capabilities, non-destructive assay training was done at Los Alamos National Lab. of U.S. through the agreement of MOST and DOE agreement, and information on DA technology was exchanged at Nuclear Material Control Center of Japan. (author). 22 tabs., 52 figs., 53 refs.

1996-01-01

179

Safeguards -Safeguards system development support-  

Energy Technology Data Exchange (ETDEWEB)

This project mainly focused to technically support national safeguards inspection which is scheduled in the beginning of 1997. It includes non-destructive assay of nuclear fuels, analysis on inspection and environmental samples, remote monitoring of nuclear activities and its analysis, survey on remote sensing of satellite for safeguards application. Non-destructive assay of nuclear fuels dealt with development on verification of spent fuels with emphasis to fabrication of inspection tools with surveillance and gamma measurement on CANDU spent fuels. For sample analysis, study was carried out on process inspection sample analysis method. In addition to this, ultra low background laboratory was set up to execute environmental and swipe samples and sample treatment techniques including water, soil, plant, et al. were researched. Tritiums which were sampled around power plants were analysed. With cooperation of Satellite Technology Research Center of KAIST, use of civilian satellite imagery was surveyed. To train facility operators for safeguards, various technology on non-destructive assay was lectured to personnel of Korea Electric Power Corporation. And to enhance out capabilities, non-destructive assay training was done at Los Alamos National Lab. of U.S. through the agreement of MOST and DOE agreement, and information on DA technology was exchanged at Nuclear Material Control Center of Japan. (author). 22 tabs., 52 figs., 53 refs.

Kwack, E. H.; Kim, B. K.; Hong, J. S.; Sin, J. S.; Yoon, W. K.; Ahn, J. S.; Yoon, S. C.; Ahn, J. S.; Lee, Y. K.; Kim, J. S.; Lee, Y. D.; Na, W. W.

1996-12-01

180

Defining the pathway for Tat-mediated delivery of beta-glucuronidase in cultured cells and MPS VII mice.  

UK PubMed Central (United Kingdom)

We used recombinant forms of human beta-glucuronidase (GUS) purified from secretions from stably transfected CHO cells to compare the native enzyme to a GUS-Tat C-terminal fusion protein containing the 11-amino-acid HIV Tat protein transduction domain for: (1) susceptibility to endocytosis by cultured cells, (2) rate of clearance following intravenous infusion, and (3) tissue distribution and effectiveness in clearing lysosomal storage following infusion in the MPS VII mouse. We found: (1) Native GUS was more efficiently taken up by cultured human fibroblasts and its endocytosis was exclusively mediated by the M6P receptor. The GUS-Tat fusion protein showed only 30-50% as much M6P-receptor-mediated uptake, but also was taken up by adsorptive endocytosis through binding of the positively charged Tat peptide to cell surface proteoglycans. (2) GUS-Tat was less rapidly cleared from the circulation in the rat (t(1/2) = 13 min vs 7 min). (3) Delivery to most tissues of the MPS VII mouse was similar, but GUS-Tat was more efficiently delivered to kidney. Histology showed that GUS-Tat more efficiently reduced storage in renal tubules, retina, and bone. These studies demonstrate that Tat modification can extend the range of tissues corrected by infused enzyme.

Orii KO; Grubb JH; Vogler C; Levy B; Tan Y; Markova K; Davidson BL; Mao Q; Orii T; Kondo N; Sly WS

2005-08-01

 
 
 
 
181

Defining the pathway for Tat-mediated delivery of beta-glucuronidase in cultured cells and MPS VII mice.  

Science.gov (United States)

We used recombinant forms of human beta-glucuronidase (GUS) purified from secretions from stably transfected CHO cells to compare the native enzyme to a GUS-Tat C-terminal fusion protein containing the 11-amino-acid HIV Tat protein transduction domain for: (1) susceptibility to endocytosis by cultured cells, (2) rate of clearance following intravenous infusion, and (3) tissue distribution and effectiveness in clearing lysosomal storage following infusion in the MPS VII mouse. We found: (1) Native GUS was more efficiently taken up by cultured human fibroblasts and its endocytosis was exclusively mediated by the M6P receptor. The GUS-Tat fusion protein showed only 30-50% as much M6P-receptor-mediated uptake, but also was taken up by adsorptive endocytosis through binding of the positively charged Tat peptide to cell surface proteoglycans. (2) GUS-Tat was less rapidly cleared from the circulation in the rat (t(1/2) = 13 min vs 7 min). (3) Delivery to most tissues of the MPS VII mouse was similar, but GUS-Tat was more efficiently delivered to kidney. Histology showed that GUS-Tat more efficiently reduced storage in renal tubules, retina, and bone. These studies demonstrate that Tat modification can extend the range of tissues corrected by infused enzyme. PMID:16043103

Orii, Koji O; Grubb, Jeffrey H; Vogler, Carole; Levy, Beth; Tan, Yun; Markova, Kamelia; Davidson, Beverly L; Mao, Q; Orii, Tadao; Kondo, Naomi; Sly, William S

2005-08-01

182

Common N-acetylgalactosamine-6-sulfate sulfatase (GALNS) exon mutations in Brazilian patients with mucopolysaccharidosis IVA (MPS IVA)  

Scientific Electronic Library Online (English)

Full Text Available Abstract in english Morquio A Syndrome (mucopolysaccharidosis IVA - MPS IVA, OMIM# 253000) is an autosomal recessive inborn error of metabolism caused by the deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS). We investigated five unrelated Brazilian MPS IVA families for mutations in exons 4, 5, 9 and 10 of the GALNS gene. Six out of the 10 mutant alleles were identified. Taken together with a previous study, which included six unrelated families, common mutations among Brazilia (more) n patients were p.N164T, p.G116S and p.G301C. Among one hundred control subjects three novel silent mutations were found (p.A107A; GCC -> GCT, p.Y108Y; TAC -> TAT, p.P357P; CCG -> CCA). Screening starting with exons 4, 5, 9, 10 and 11 may be a good strategy for genotyping of Brazilian patients since these exons include 73% of all mutations identified in the current and previous studies.

Dieter, Tatiana; Matte, Ursula da Silveira; Schwartz, Ida Vanessa; Tomatsu, Shunji; Giugliani, Roberto

2007-01-01

183

New forth-based development system  

Energy Technology Data Exchange (ETDEWEB)

Because of the software design and development difficulties of integrating several real time control functions into a single imbedded microcomputer controller, and because a single microcomputer may have difficulty performing all of the real time control functions fast enough, there is a definite trend toward using several integrated microcomputers for these types of real time controller applications. This paper described a development system which has been specifically designed for developing integrated multicomputer systems and outlines why the language forth was chosen for the development system.

Smith, G.H.

1982-01-01

184

Development of Environmental Radiation Monitoring System  

Energy Technology Data Exchange (ETDEWEB)

This paper is a final report of the research project which is development of environmental radiation monitoring system(ERMS) for nuclear power plant(NPP) area. It contains -Analysis and design for the developments of ERMS -Study on radiation monitoring systems and Environmental radiation detection methods -H/W development : Counter and ion interface, Dose conversion unit, Single channel analyzer, Microprocessor controller -S/W development : Communication, Control, and Operation program - And the performance analysis and test results of the system for Kori NPP operation. (author). 48 refs., 19 figs., 22 tabs.

Choi, S.S.; Oh, G.H.; Chang, T.W.; Jang, T.I. [Korea Electric Power Research Institute, Taejeon (Korea, Republic of); Lee, K.H.; Ha, D.K.; Jung, Y.J.; Ro, W.Y.; Shin, D.Y.; Jang, S.B.; Shin, H.M.; Cho, H.S. [Electrical Engineering and Science Research Institute, Seoul (Korea, Republic of)

1997-12-31

185

Development of Residential SOFC Cogeneration System  

International Nuclear Information System (INIS)

Since 2001 Kyocera has been developing 1kW class Solid Oxide Fuel Cell (SOFC) for power generation system. We have developed a cell, stack, module and system. Since 2004, Kyocera and Osaka Gas Co., Ltd. have been developed SOFC residential co-generation system. From 2007, we took part in the 'Demonstrative Research on Solid Oxide Fuel Cells' Project conducted by New Energy Foundation (NEF). Total 57 units of 0.7kW class SOFC cogeneration systems had been installed at residential houses. In spite of residential small power demand, the actual electric efficiency was about 40%(netAC,LHV), and high CO2 reduction performance was achieved by these systems. Hereafter, new joint development, Osaka Gas, Toyota Motors, Kyocera and Aisin Seiki, aims early commercialization of residential SOFC CHP system.

2011-01-01

186

Development of Residential SOFC Cogeneration System  

Science.gov (United States)

Since 2001 Kyocera has been developing 1kW class Solid Oxide Fuel Cell (SOFC) for power generation system. We have developed a cell, stack, module and system. Since 2004, Kyocera and Osaka Gas Co., Ltd. have been developed SOFC residential co-generation system. From 2007, we took part in the "Demonstrative Research on Solid Oxide Fuel Cells" Project conducted by New Energy Foundation (NEF). Total 57 units of 0.7kW class SOFC cogeneration systems had been installed at residential houses. In spite of residential small power demand, the actual electric efficiency was about 40%(netAC,LHV), and high CO2 reduction performance was achieved by these systems. Hereafter, new joint development, Osaka Gas, Toyota Motors, Kyocera and Aisin Seiki, aims early commercialization of residential SOFC CHP system.

Ono, Takashi; Miyachi, Itaru; Suzuki, Minoru; Higaki, Katsuki

2011-06-01

187

Development of sorting system control using LABVIEW  

International Nuclear Information System (INIS)

[en] The development of the Personnel Dosimeter Sorting System, proposed by the Secondary Standard Dosimetry Laboratory (SSDL) is to enhance the system or work flow in preparing the personnel dosimeter. The main objective of the system is to reduce stamping error, time and cost. The Personnel Dosimeter Sorting System is a semi-automatic system with an interfacing method using the Advantec 32 bit PCI interface card of 64 digital input and output. The system is integrated with the Labview version 7.1 programming language to control the sorting system and operation. (Author)

2005-01-01

188

Advanced Thermal Barrier Coating System Development  

Energy Technology Data Exchange (ETDEWEB)

The objectives of the program are to provide an improved Thermal Barrier Coating (TBC) system with increased temperature capability and improved reliability relative to current state of the art TBC systems. The development of such a coating system is essential to the ATS engine meeting its objectives. The base program consists of three phases: Phase I: Program Planning - Complete; Phase II: Development; and Phase III: Selected Specimen - Bench Test Work is being performed in Phase II and III of the program.

NONE

1999-03-31

189

Development of a computer information management system.  

UK PubMed Central (United Kingdom)

The Department of Veterans Affairs, Social Work Service has designed, developed and implemented the Social Work Information Management System (SWIMS) which provides for both administrative and clinical reporting. The system is clinically based and includes an option for case recording. The social work staff, who will use the system, was integrally involved in all phases of planning. The processes of the design, development, testing and implementation are discussed.

Grishman MH

1995-01-01

190

Development of a computer information management system.  

Science.gov (United States)

The Department of Veterans Affairs, Social Work Service has designed, developed and implemented the Social Work Information Management System (SWIMS) which provides for both administrative and clinical reporting. The system is clinically based and includes an option for case recording. The social work staff, who will use the system, was integrally involved in all phases of planning. The processes of the design, development, testing and implementation are discussed. PMID:8658320

Grishman, M H

1995-01-01

191

Development of energy harvester system for avionics  

Science.gov (United States)

This paper deals with an energy harvesting system for avionics; it is an energy source for a unit which is used for wireless monitoring or autonomous control of a small aircraft engine. This paper is focused on development process of energy harvesting system from mechanical vibrations in the engine area. The used energy harvesting system consists of an electro-magnetic energy harvester, power management and energy storage element. The energy harvesting system with commercial power management circuits have to be tested and verified measured results are used for an optimal redesign of the electro-magnetic harvester. This developmental step is necessary for the development of the optimal vibration energy harvesting system.

Hadas, Z.; Vetiska, V.; Ancik, Z.; Ondrusek, C.; Singule, V.

2013-05-01

192

Development of advanced solar assisted drying systems  

Energy Technology Data Exchange (ETDEWEB)

The Solar Energy Research Group in the Universiti Kebangsaan Malaysia has been set-up more than two decades ago. One of the activities is in the field of solar thermal process, particularly in development of solar assisted drying systems. Solar drying systems technical development can proceed in two directions. Firstly simple, low power, short life, and comparatively low efficiency-drying system. Secondly, the development of high efficiency, high power, long life expensive solar drying system. The group has developed four solar assisted drying systems namely (a) the V-groove solar collector, (b) the double-pass solar collector with integrated storage system, (c) the solar assisted dehumidification system for medicinal herbs and (d) the photovoltaic thermal (PVT) collector system. The common problems associated with the intermittent nature of solar radiation and the low intensities of solar radiation in solar thermal systems can be remedied using these types of solar drying systems. These drying systems have the advantages of heat storage, auxiliary energy source, integrated structure control system and can be use for a wide range of agricultural produce. [Author].

Othman, M.Y.H.; Yatim, B. [Department of Physics, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor (Malaysia); Sopian, K.; Daud, W.R.W. [Department of Mechanical and Materials Engineering, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor (Malaysia)

2006-04-15

193

New developments in multi-meson systems  

CERN Multimedia

New developments in the study of multi-meson systems are reviewed. We highlight a new recursive algorithm for generating the requisite contractions needed for studying complex systems of mesons involving large numbers of particles or multiple species of particles. First results on mixed species systems involving pions and kaons are also presented.

Detmold, William

2010-01-01

194

Development of MARS coupled code system  

International Nuclear Information System (INIS)

[en] MARS coupled code system has been developed by KAERI for multi-dimensional thermal-hydraulic system analysis coupled with a three-dimensional core kinetics code, MASTER, and containment thermal-hydraulic codes, CONTAIN or CONTEMPT. Multi-dimensional system analysis capability of the MARS was attained by implicitly integrating the hydrodynamics of RELAP5 and COBRA-TF and unifying thermal-hydraulic models. In addition, various advanced thermal-hydraulic models have been developed and incorporated in the MARS for enhanced code capability. For the coupled analysis, MASTER, CONTAIN or CONTEMPT codes were coupled with the MARS calculation using dynamic link library (DLL) techniques of Windows system. Then, the graphic system analyzer, ViSA, was developed and linked with the MARS for a user-friendly computing environment. From various code benchmark and plant calculations, it was demonstrated that the MARS coupled code system is a viable tool for the safety analysis of nuclear reactor systems. (author)

2007-01-01

195

Prehospital System Development in Jaffna, Sri Lanka.  

UK PubMed Central (United Kingdom)

Introduction The building of prehospital emergency medical care systems in developing and lower middle-income countries (as defined by the World Bank) is a critical step in those countries' efforts to reduce unnecessary morbidity and mortality. This case report presents the development of a prehospital care system in Jaffna District, Sri Lanka and provides the results of the system's first year of operations, the likely reasons for the results, and the prospects for sustained operations of the system. The goal of this report is to add to the literature surrounding Emergency Medical Services (EMS) in developing countries by providing insight into the implementation of a prehospital emergency care system in developing and lower middle-income settings. METHODS: The level of utilization and the financial performance of the system during its first year of operation were analyzed using data from the Jaffna Regional Director of Health Services (RDHS) Call Center database and information from the implementing organization, Medical Teams International. RESULTS: The system responded to >2000 emergency calls in its first 11 months of operation. The most utilized ambulance of the system experienced only a US $13.50 loss during the first 12 months of operation. Factors such as up-front support, a systematic approach, and appropriateness contributed to the successful implementation of the Jaffna prehospital EMS system. CONCLUSION: The implementation of a prehospital EMS system and its functioning were successful in terms of utility and, in many regards, financial stability. The system's success in development may serve as a potential model for implementing prehospital emergency medical care in other developing and lower middle-income country settings, keeping in mind factors outside of the system that were integral to its developmental success. Zimmerman JR , Bertermann KM , Bollinger PJ , Woodyard DR . Prehospital system development in Jaffna, Sri Lanka. Prehosp Disaster Med. 2013;28(5):1-8.

Zimmerman JR; Bertermann KM; Bollinger PJ; Woodyard DR

2013-07-01

196

Managing the Development of Comprehensive Instructional Systems.  

Science.gov (United States)

Identifies six stages for the development of a comprehensive instructional system (planning, design, development, implementation, management transfer, client operation) and describes briefly the general purpose of each stage as it relates to the total development efforts. Maintaining a strong user orientation and involvement at each stage is…

Baker, Robert L.; Elam, Robert J.

1978-01-01

197

Ultrasonic systems and system development at SNL Albuquerque  

Energy Technology Data Exchange (ETDEWEB)

With completion of the High Precision Ultrasonic Scanning System (HPUSS) and purchase of the Olympus acoustic microscope, the SNL Albuquerque NDE divisions now have the capability to ultrasonically scan almost any size and shape of test object. The general purpose ultrasonic scanning system, the high precision ultrasonic scanning system, and the acoustic microscope cover a wide resolution and magnification range. The rest of this paper describes the three systems in more detail and talks about future ultrasonic system development at Sandia. 5 figs.

Shurtleff, W.W.

1989-01-01

198

Development of linked vacuum interlock protection systems  

International Nuclear Information System (INIS)

Three linked vacuum interlock protection systems were developed for three U7 stations shared one beam line of National Synchrotron Radiation Laboratory. The system control principle, logical points and method were described. Optical fibre was used for communications between beam lines. By implementing the protection system, reliability and anti-jamming of the system were enhanced with fast response time. The response time of FCV valve can be reduced to 8 ms. (authors)

2009-01-01

199

System model development for nuclear thermal propulsion  

Energy Technology Data Exchange (ETDEWEB)

A critical enabling technology in the evolutionary development of nuclear thermal propulsion (NTP) is the ability to predict the system performance under a variety of operating conditions. Since October 1991, US (DOE), (DOD) and NASA have initiated critical technology development efforts for NTP systems to be used on Space Exploration Initiative (SEI) missions to the Moon and Mars. This paper presents the strategy and progress of an interagency NASA/DOE/DOD team for NTP system modeling. It is the intent of the interagency team to develop several levels of computer programs to simulate various NTP systems. An interagency team was formed for this task to use the best capabilities available and to assure appropriate peer review. The vision and strategy of the interagency team for developing NTP system models will be discussed in this paper. A review of the progress on the Level 1 interagency model is also presented.

Walton, J.T. [National Aeronautics and Space Administration, Cleveland, OH (United States). Lewis Research Center; Hannan, N.A. [Argonne National Lab., IL (United States); Perkins, K.R. [Brookhaven National Lab., Upton, NY (United States); Buksa, J.J. [Los Alamos National Lab., NM (United States); Worley, B.A. [Oak Ridge National Lab., TN (United States); Dobranich, D. [Sandia National Labs., Albuquerque, NM (United States)

1992-10-01

200

System model development for nuclear thermal propulsion  

International Nuclear Information System (INIS)

A critical enabling technology in the evolutionary development of nuclear thermal propulsion (NTP) is the ability to predict the system performance under a variety of operating conditions. Since October 1991, US (DOE), (DOD) and NASA have initiated critical technology development efforts for NTP systems to be used on Space Exploration Initiative (SEI) missions to the Moon and Mars. This paper presents the strategy and progress of an interagency NASA/DOE/DOD team for NTP system modeling. It is the intent of the interagency team to develop several levels of computer programs to simulate various NTP systems. An interagency team was formed for this task to use the best capabilities available and to assure appropriate peer review. The vision and strategy of the interagency team for developing NTP system models will be discussed in this paper. A review of the progress on the Level 1 interagency model is also presented

1992-09-05

 
 
 
 
201

Gas tagging system development in Japan  

International Nuclear Information System (INIS)

The Gas tagging method has been considered to be most desirable for a failed fuel location system for the fast breeder reactor, regarding the component reduction in the reactor vessel and rapid location during reactor operation. The gas tagging system has been designed by referring to R and D results obtained in Japan and other countries. The designed system is comprised of tag gas filling pins, cover gas sampling system, tag gas recovery and enrichment system, tag gas analyzer and system control and data handling computers. The main specifications for this system have been decided as follows; 1) Main function is location of failed fuels in core and a part of blanket region, 2) Identification capability is each subassembly, 3) Time for identification is within a few days, 4) Continuous operation with automatic start at fuel failure, 5) Detection sensitivity must cover both gas leak and pin burst. In designing the gas tagging system, the following R and D items were selected; 1) System design study, 2) Tag gas capsule development, 3) Modeling the tag gas behavior in reactor primary cooling system, 4) Tag gas recovery and enrichment system, 5) Computer code development for tag gas isotope ratio change estimation. Details of the Japanese gas tagging system development appear in this paper. (author).

1981-01-01

202

Development of the Digital Reactor Safety System  

International Nuclear Information System (INIS)

Objectives of Project - Development of Digital Safety Grade PLC and Licensing - Development of Safety System(RPS) and Licensing - Development of Safety System(ESF-CCS) and Licensing Content and Result of Project - POSAFE-Q PLC : Development of PLC platform for Shin-UCN unit 1 and 2 ·Development Scope : Processor module, Power module, 3 kinds of Communication module, Bus extension module(Master and Slave), 16 kinds of Input and Output module ·PLC application software development tool(pSET) - IDiPS RPS and IDiPS ESF-CCS : Development of PPS for Sin-UCN 1 and 2 ·Development Scope - 4-channels RPS with the KNICS inherent architecture - A part of 1-channels ESF-CCS with the KNICS inherent architecture - Licensing ·optical Report Submitted and Expected to finish the licensing process until Aug. 2008

2008-01-01

203

Development of the Digital Reactor Safety System  

Energy Technology Data Exchange (ETDEWEB)

Objectives of Project - Development of Digital Safety Grade PLC and Licensing - Development of Safety System(RPS) and Licensing - Development of Safety System(ESF-CCS) and Licensing Content and Result of Project - POSAFE-Q PLC : Development of PLC platform for Shin-UCN unit 1 and 2 {center_dot}Development Scope : Processor module, Power module, 3 kinds of Communication module, Bus extension module(Master and Slave), 16 kinds of Input and Output module {center_dot}PLC application software development tool(pSET) - IDiPS RPS and IDiPS ESF-CCS : Development of PPS for Sin-UCN 1 and 2 {center_dot}Development Scope - 4-channels RPS with the KNICS inherent architecture - A part of 1-channels ESF-CCS with the KNICS inherent architecture - Licensing {center_dot}optical Report Submitted and Expected to finish the licensing process until Aug. 2008.

Lee, Dong Young; Lee, C. K.; Hwang, I. K. (and others)

2008-04-15

204

High dose genistein aglycone therapy is safe in patients with mucopolysaccharidoses involving the central nervous system.  

UK PubMed Central (United Kingdom)

Genistein (4,5,7-trihydroexyisoflavone), a soy derived isoflavone, has been proposed as a substrate reduction therapy in patients with mucopolysaccharidoses (MPS) disorders with central nervous system involvement based on studies in cultured fibroblasts demonstrating that this agent inhibits glycosaminoglycan synthesis. Several studies have reported treatment of MPS III patients with low dose genistein (5-15mg/kg/day) with no serious adverse effects and variable neurocognitive outcomes. Mice with MPS IIIB treated with high dose (160mg/kg/day) genistein exhibited a significant decrease in heparan sulfate accumulation and neuroinflammation in the brain and improvement of the behavioral phenotype. No study to date has been performed using high dose genistein treatment in MPS patients. We initiated an open label study to assess the safety of high dose genistein treatment in MPS patients with neurological impairment. Twenty-two eligible patients were treated at least 12months with pure synthetic genistein at a dose of 150mg/kg/day. Safety labs, urine GAG levels, clinical status and history of adverse events were obtained every 3months and physical examination was performed by single examiner at least every 12months. While neurocognitive level was not a primary endpoint, participants were asked to obtain annual neurocognitive testing if available and a 9 point disability scale (FPSS) was recorded at each study visit. In the course of 12months of treatment, we observed no serious adverse events that were unexplained by the underlying condition and no severe adverse events that were felt to be potentially related to the genistein therapy. Two male subjects developed Tanner II breast development not present at baseline which could be related to the mild estrogenic effects of genistein. We observed no consistent decline in urine GAG levels; however, urinary GAG excretion was erratic. After 12months, the FPSS remained unchanged in 16 patients and declined by 1 point in 2 patients. Based on the results obtained so far, high dose oral genistein therapy appears to be safe in MPS patients and additional testing in a larger randomized placebo controlled trial is needed to further assess safety and efficacy.

Kim KH; Dodsworth C; Paras A; Burton BK

2013-08-01

205

Development of coaxial counterrotating rotary tilling system  

Energy Technology Data Exchange (ETDEWEB)

A computer simulation of the soil reaction force was very helpful to develop the new rotary tilling system of a walking tractor which uses coaxial simultaneously counterrotating blades to stabilize the tractor while tilling. The simulation revealed that the fluctuation of the soil reaction force generated by the new tilling system retaining a conventional blade arrangement is great compared with the ordinary tilling system, and that the system with an appropriate blade arrangement improves this fluctuation. The walking tractor developed using this computer simulation tool demonstrates the capability of being operated stably up to its maximum output of rotary shafts.

Kokuryo, Takashi; Kobayashi, Hideaki; Takeuchi, Masashi; Nagaoka, Masatoshi

1995-12-31

206

MODERN FACTORS OF UKRAINIAN EDUCATION SYSTEM DEVELOPMENT ??????? ??????? ???????? ??????? ?????? ???????  

Directory of Open Access Journals (Sweden)

Full Text Available Influence of integration, democratization and informatization society processes on the development and forming of education systems aims in European countries as well as in Ukraine is analyzed in the paper. It is considered the development of Ukrainian education system in direction of European integration, Bologna process, integration to the European education systems. Such modern phenomena as unified educational space, global educational space and open educational environment of education systems as well as the key role of information and communication technologies playing a great role in these processes have been determined and analyzed.? ?????? ?????????????? ????? ???????? ??????????, ?????????????? ?? ?????????????? ??????????? ?? ???????? ?? ?????????? ????? ?????? ?????? ?? ? ???????????? ???????,. ??? ? ? ???????. ?????????? ???????? ??????? ?????? ??????? ? ???????? ???????????? ??????????, ??????????? ???????, ?????????? ?? ???????????? ?????? ??????. ????????? ?? ?????????????? ???? ??????? ????? ?? ?????? ???????? ???????, ?????????? ???????? ??????? ?? ???????? ????????? ?????????? ?????? ??????, ? ????? ??????? ???? ????????????-?????????????? ??????????, ??? ???? ?????????? ? ??? ????????.

?.?. ?????

2010-01-01

207

[Therapy for systemic metabolic disorders based on the detection of basic corneal landmarks in childhood].  

UK PubMed Central (United Kingdom)

Many systemic lysosomal storage disorders show basic corneal opacities already in childhood. The lysosome is a cell organelle, produced by Golgi's apparatus, that is surrounded by a membrane and contains hydrolytic enzymes that break down food molecules, especially proteins and other complex molecules. The ophthalmologist's precise diagnosis of corneal clouding at the slit-lamp may reveal the correct interpretation of the specific lysosomal storage disorder. It is very important to diagnose such diseases as soon as possible because today the development of systemic enzymatic therapies has broadened the therapeutic armamentarium for the current standard of care. The following corneal landmarks of systemic storage diseases and of the modern systemic therapy are presented: cornea verticillata in Fabry's disease, periodic infusion of alpha-galactosidase a; Kayser-Fleischer's ring in Wilson's disease, zinc, trienetin, low copper diet; multiple, punctiform crystals in cystinosis, cysteamine, Raptor RP 103(DR cysteamine) that reduces the cytotoxity in form of continous dissolving of cystine from lysosome, renal transplantation, haematopoietic stem cell transplantation; peripheral ring, but not true lipid arc, and moderate stromal haze in LCAT-deficiency, injection of recombinant enzyme or of encapsulated LCAT-secreting cells; diffuse stromal haze in mucopolysaccharidoses (MPS). Enzyme replacement therapy is currently indicated for MPS I, MPS II, and MPS VI, haematopoietic stem cell transplantation; painful, bilateral pseudo-dendritic opacities in tyrosinemia type II (eponym: Richner-Hanhart syndrome), low phenylalanine and tyrosine diet result in complete disappearance of corneal alterations with a consecutive painfree period. Strict diet during the whole life is necessary to prevent corneal recurrences and the occurrence of palmo-plantar keratoses. Such therapies can enable the patient to lead an otherwise normal life for decades.

Lisch W; Pitz S; Geerling G

2013-06-01

208

Some Problems in Large Superconducting System Development.  

Science.gov (United States)

The experience in developments of large superconducting magnetic systems (SMS) for investigations into controlled fusion, accumulated in the Kurchatov Institute of Atomic Energy, is analyzed. The early operating SMS of the immersion and circulation type a...

D. P. Ivanov V. E. Keilin E. Y. Klimenko A. D. Nikulin D. A. Panov

1977-01-01

209

DOE/SCS Power Systems Development Facility.  

Science.gov (United States)

The use of coal for power generation has come under increasing environmental scrutiny over the past five years. Advances in coal-based power generation technology will continue to develop towards systems that have high efficiency, environmental superiorit...

Z. U. Haq T. E. Pinkston R. E. Sears P. Vimalchand

1993-01-01

210

Equipment system for advanced nuclear fuel development  

International Nuclear Information System (INIS)

[en] The purpose of the settlement of equipment system for nuclear Fuel Technology Development Facility(FTDF) is to build a seismic designed facility that can accommodate handling of nuclear materials including

2002-01-01

211

Development of Architectures for Internet Telerobotics Systems  

CERN Multimedia

This paper presents our experience in developing and implementing Internet telerobotics system. Internet telerobotics system refers to a robot system controlled and monitored remotely through the Internet. A robot manipulator with five degrees of freedom, called Mentor, is employed. Client-server architecture is chosen as a platform for our Internet telerobotics system. Three generations of telerobotics systems have evolved in this research. The first generation was based on CGI and two tiered architecture, where a client presents a Graphical User Interface to the user, and utilizes the user's data entry and actions to perform requests to robot server running on a different machine. The second generation was developed using Java. We also employ Java 3D for creating and manipulating 3D geometry of manipulator links and for constructing the structures used in rendering that geometry, resulting in 3D robot movement simulation presented to the users(clients) through their web browser. Recent development in our In...

Bambang, Riyanto

2008-01-01

212

Development of a simplified piping support system  

International Nuclear Information System (INIS)

This paper presents the results of experimental and analytical studies for developing a simplified piping support system (SPSS) for nuclear power piping in place of snubbers. The basic concept of the SPSS is a passive seismic support system consisting of limit stops. Large gaps are provided to allow for free thermal expansion during normal plant operation while preventing excessive displacement during a seismic event. The results are part of a research and development program sponsored by EPRI. (orig./HP)

1987-01-01

213

Development of Cooling System for Gyrotron Collector  

Science.gov (United States)

In this paper, the development of cooling system for 42 GHz, 200 kW gyrotron collector is presented. The design of the cooling duct has been finalized after different analyses such as, the fluid analysis, the thermal analysis, the structural analysis, etc. All analyses have been carried out by ANSYS software and the development of the cooling system based on the final design is performed.

Goswami, Uttam Kumar; Singh, Udaybir; Kumar, Nitin; Sahu, Naveen Kumar; Kumar, Anil; Yadav, Vivek; Kumar, Manoj; Khatun, Hasina; Dua, Rajeshwar Lal; Sinha, A. K.

2013-08-01

214

Motor Development International: Compressed Air Technology Systems  

Science.gov (United States)

How does a car that boasts "zero pollution" and even "cleans the air it uses" work? This website provides information on the air compression cars developed by Motor Development International. Aside from the general overview of the mechanics of air compression, the FAQ section provides additional information on the air tanks, filter system, body frame, electric system and MDI's business model. A key target for this website seems to be potential buyers and investors.

215

Hydrogen storage and delivery system development: Fabrication  

Energy Technology Data Exchange (ETDEWEB)

Hydrogen storage and delivery is an important element in effective hydrogen utilization for energy applications and is an important part of the FY1994-1998 Hydrogen Program Implementation Plan. This project is part of the Field Work Proposal entitled Hydrogen Utilization in Internal Combustion Engines (ICE). The goal of the Hydrogen Storage and Delivery System Development Project is to expand the state-of-the-art of hydrogen storage and delivery system design and development. At the foundation of this activity is the development of both analytical and experimental evaluation platforms. These tools provide the basis for an integrated approach for coupling hydrogen storage and delivery technology to the operating characteristics of potential hydrogen energy use applications. Analytical models have been developed for internal combustion engine (ICE) hybrid and fuel cell driven vehicles. The dependence of hydride storage system weight and energy use efficiency on engine brake efficiency and exhaust temperature for ICE hybrid vehicle applications is examined. Results show that while storage system weight decreases with increasing engine brake efficiency energy use efficiency remains relatively unchanged. The development, capability, and use of a newly developed fuel cell vehicle hydride storage system model will also be discussed. As an example of model use power distribution and control for a simulated driving cycle is presented. An experimental test facility, the Hydride Bed Testing Laboratory (HBTL) has been designed and fabricated. The development of this facility and its use in storage system development will be reviewed. These two capabilities (analytical and experimental) form the basis of an integrated approach to storage system design and development. The initial focus of these activities has been on hydride utilization for vehicular applications.

Handrock, J.L.; Malinowski, M.E.; Wally, K. [Sandia National Lab., Livermore, CA (United States)

1996-10-01

216

Development of radiation detection and measurement systems - Development of industrial CT system using radiation  

Energy Technology Data Exchange (ETDEWEB)

It needs proper quality inspection systems to develop various industries and it is possible to prevent big accidents by precise inspection to component of industrial facilities. Computed tomography is one of the most precise nondestructive inspection system which enables us to know shape, size and location of flaw in the object. Therefore to develop the industrial computed tomography system, radiation collimators, a mechanical scanning system, hardware and software for automatic control were developed, which are important components of computed tomography. The developed system is applicable to radiometric system which can measure the remaining thickness of insulated pipe and deposit inside in it with real time. 14 refs., 26 figs., 3 tabs. (Author)

Lee, Jeong Ki; Lee, Sung Sik; Lim, Sung Jin; Kim, Un Ki; Kwon, Jin O [Korea Inspection and Engineering Co. Ltd., Seoul (Korea)

2000-03-01

217

System analysis: Developing tools for the future  

Energy Technology Data Exchange (ETDEWEB)

This report introduces and evaluates system analysis tools that were developed, or are under development, for the Robotics Technology Development Program (RTDP). Additionally, it discusses system analysis work completed using these tools aimed at completing a system analysis of the retrieval of waste from underground storage tanks on the Hanford Reservation near Richland, Washington. The tools developed and evaluated include a mixture of commercially available tools adapted to RTDP requirements, and some tools developed in house. The tools that are included in this report include: a Process Diagramming Tool, a Cost Modeling Tool, an Amortization Modeling Tool, a graphical simulation linked to the Cost Modeling Tool, a decision assistance tool, and a system thinking tool. Additionally, the importance of performance testing to the RTDP and the results of such testing executed is discussed. Further, the results of the Tank Waste Retrieval (TWR) System Diagram, the TWR Operations Cost Model, and the TWR Amortization Model are presented, and the implication of the results are discussed. Finally, the RTDP system analysis tools are assessed and some recommendations are made regarding continuing development of the tools and process.

De Jong, K.; clever, J.; Draper, J.V.; Davies, B.; Lonks, A.

1996-02-01

218

Development of a remote building monitoring system  

Energy Technology Data Exchange (ETDEWEB)

The authors describe the design, development and initial operation of a prototype system which permits remote monitoring of multiple heterogeneous commercial buildings across the Internet from a single control center. Their system is distinguished by its ability to interface to multiple heterogeneous legacy building Energy Management Control Systems (EMCSs), its use of the Common Object Request Broker Architecture (CORBA) standard communication protocols, development of a standardized naming system for monitoring points, the use of a relational DBMS to store time series data, automatic unit conversion, and a scripted time series visualization system. The authors discuss design decisions related to the selection of CORBA and a relational DBMS implementation. They also discuss related standards efforts such as BACnet and the International Alliance for Interoperability. They conclude with discussions of the HVAC system data and future work.

Olken, F.; Jacobsen, H.A.; McParland, C.; Piette, M.A.; Anderson, M.F.

1998-07-01

219

The development of highwall mining systems  

Energy Technology Data Exchange (ETDEWEB)

Highwall mining has existed in many forms for several decades. This paper analyses the recent advance in highwall mining with the development of the Addcar[trademark] mining system. The paper provides an historical perspective of various systems over the last thirty years.

Seear, P.K. (Joy Industries Inc. (United States). Markets and Products Dept.)

1994-01-01

220

Development of BEPC II injection control system  

International Nuclear Information System (INIS)

The functions of BEPC II injection control system are switching on/off the kicker power supplies and setting voltage locally and remotely, monitoring the current, voltage and their status, collecting waveform signals of the pulsed power supplies with oscilloscopes and sending them to a VME IOC. This paper describes the control system and development of applications and IOC database with EPICS. (authors)

2006-01-01

 
 
 
 
221

Developing a usable performance appraisal system.  

UK PubMed Central (United Kingdom)

A sound, effective performance appraisal system is an important management tool for the nursing administrator. The author describes an approach to developing a performance appraisal system that yields reliable information about performance and is trusted and accepted by both appraisers and appraisees.

Brief AP

1979-10-01

222

Development of the OASIS acquisition system  

International Nuclear Information System (INIS)

OASIS is a general purpose data acquisition system built at IPN Orsay, which has been developed around UNIX and VME real time processors. This system can be used to acquire, process, store and display physics data. New OASIS is also used to process event data tapes coming from experiments and has been connected to the analysis software at IPN. (author)

1999-01-01

223

Development of advanced gas turbine systems  

Energy Technology Data Exchange (ETDEWEB)

The objective of the Advanced Turbine Systems study is to investigate innovative natural gas fired cycle developments to determine the feasibility of achieving 60% efficiency within a 8-year time frame. The potential system was to be environmentally superior, cost competitive and adaptable to coal-derived fuels. Progress is described.

Bannister, R.L.; Little, D.A.; Wiant, B.C.

1993-11-01

224

Self-unloading systems - development continues  

Energy Technology Data Exchange (ETDEWEB)

A survey is presented of recent developments by major manufacturers of self loading/unloading systems. These manufacturers are: BMH Marine Global Self-Unloaders, HW Carlsen, Kvaerner Ships Equipment, and Maritas. Design developments are described and details given of recent deliveries. 1 fig., 3 photos.

NONE

1995-02-01

225

Increased levels of circulating microparticles in primary Sjögren's syndrome, systemic lupus erythematosus and rheumatoid arthritis and relation with disease activity  

Digital Repository Infrastructure Vision for European Research (DRIVER)

INTRODUCTION: Cell stimulation leads to the shedding of phosphatidylserine (PS)-rich microparticles (MPs). Because autoimmune diseases (AIDs) are characterized by cell activation, we investigated level of circulating MPs as a possible biomarker in primary Sjögren's syndrome (pSS), systemic lupus ery...

Sellam, J; Proulle, V; Jüngel, A; Ittah, M; Miceli Richard, C; Gottenberg, J E; Toti, F; Benessiano, J; Gay, S; Freyssinet, J M

226

Applications Development Using a Hybrid Artificial Intelligence Development System  

Digital Repository Infrastructure Vision for European Research (DRIVER)

This article describes our initial experience with building applications programs in a hybrid AI tool environment. Traditional AI systems developments have emphasized a single methodology, such as frames, rules or logic programming, as a methodology that is natural, efficient, and uniform. The appli...

Kunz, John C.; Kehler, Thomas P.; Williams, Michael D.

227

Development of the simulation monitoring system  

International Nuclear Information System (INIS)

[en] Large-scale simulation technique is studied at the Center for Promotion of Computational Science and Engineering for the computational science research in nuclear fields. Visualization and animation processing techniques are developed for efficient understanding of simulation results. The development of the simulation monitoring system, which is used for real-time visualization of ongoing simulations or for successive visualization of calculated results, is described in this report. The standard visualization tool AVS5 or AVS/EXPRESS is used for the simulation monitoring system, and thus, this system can be utilized in various computer environments. (author)

2001-01-01

228

Nursing Nomenclature and Classification System Development  

Directory of Open Access Journals (Sweden)

Full Text Available Classification is a rather new idea in nursing. It began as a movement to develop a language that would describe the clinical judgments made by nurses. There was great support by clinicians for describing problems that nurses are educated and licensed to treat which are not in medical language systems. Currently there are major efforts nationally and internationally to develop a nursing language system that includes nursing diagnoses, interventions and outcomes. These are the basic elements in a nursing classification for practice, minimum data set for health statistics, in costing out patient care, developing computerized patient records, and for education and research.

Gordon, M

1998-01-01

229

A Chakra System Model of Lifespan Development  

Directory of Open Access Journals (Sweden)

Full Text Available This article presents a model of lifespan development based upon the tantric chakra system. It begins with a survey of the evolution of transpersonal psychology and its alignment with eastern philosophies as previously espoused by William James, Carl Jung and others. Thechakras are defined in relation to their potential influence on psychological functioning with a focus on development beyond the level of ego stability and functioning. Building upon prior work integrating the chakra system with developmental processes, this article presents an interpretation of the chakras as a model that defines a pathway for growth-oriented development.

K. Candis Best

2010-01-01

230

System model development for nuclear thermal propulsion  

Energy Technology Data Exchange (ETDEWEB)

A critical enabling technology in the evolutionary development of nuclear thermal propulsion (NTP) is the ability to predict the system performance under a variety of operating conditions. This is crucial for mission analysis and for control subsystem testing as well as for the modeling of various failure modes. Performance must be accurately predicted during steady-state and transient operation, including startup, shutdown and post operation cooling. The development and application of verified and validated system models has the potential to reduce the design, testing, cost and time required for the technology to reach flight-ready status. Since October 1991, the US Department of Energy (DOE), Department of Defense (DOD) and NASA have initiated critical technology development efforts for NTP systems to be used on Space Exploration Initiative (SEI) missions to the Moon and Mars. This paper presents the strategy and progress of an interagency NASA/DOE/DOD team for NTP system modeling.

Hannan, N.A. [Argonne National Lab., IL (United States); Worley, B.A. [Oak Ridge National Lab., TN (United States); Walton, J.T. [National Aeronautics and Space Administration, Cleveland, OH (United States). Lewis Research Center; Perkins, K.R. [Brookhaven National Lab., Upton, NY (United States); Buksa, J.J. [Los Alamos National Lab., NM (United States); Dobranich, D. [Sandia National Labs., Albuquerque, NM (United States)

1992-11-01

231

System model development for nuclear thermal propulsion  

Energy Technology Data Exchange (ETDEWEB)

A critical enabling technology in the evolutionary development of nuclear thermal propulsion (NTP) is the ability to predict the system performance under a variety of operating conditions. This is crucial for mission analysis and for control subsystem testing as well as for the modeling of various failure modes. Performance must be accurately predicted during steady-state and transient operation, including startup, shutdown, and post operation cooling. The development and application of verified and validated system models has the potential to reduce the design, testing, and cost and time required for the technology to reach flight-ready status. Since Oct. 1991, the U.S. Department of Energy (DOE), Department of Defense (DOD), and NASA have initiated critical technology development efforts for NTP systems to be used on Space Exploration Initiative (SEI) missions to the Moon and Mars. This paper presents the strategy and progress of an interagency NASA/DOE/DOD team for NTP system modeling. It is the intent of the interagency team to develop several levels of computer programs to simulate various NTP systems. The first level will provide rapid, parameterized calculations of overall system performance. Succeeding computer programs will provide analysis of each component in sufficient detail to guide the design teams and experimental efforts. The computer programs will allow simulation of the entire system to allow prediction of the integrated performance. An interagency team was formed for this task to use the best capabilities available and to assure appropriate peer review.

Walton, J.T.; Hannan, N.A.; Perkins, K.R.; Buksa, J.H.; Worley, B.A.; Dobranich, D.

1992-08-01

232

???????????? Evolutional Development of Library Information Systems  

Directory of Open Access Journals (Sweden)

Full Text Available ???????????????????????????????,?????????,???????????????????????????,????????????????????????????????Google??????????????????????????,?????????,?????????????,????4?14??????,?????????????,?????????????????????????????????????????????????????????????????????12?????????????Library information systems are an essential tool for libraries to acquire and organize information resources to deliver services to users. With advancement of information technologies, library information systems have also evolved from card catalogue into diverse ones, such as integrated library system, elec- tronic resource management system, Amazon.com and Google Books. This article aims to review the historical development of library information systems as a basis to explore the future landscape of library information systems. Case study is adopted as research methodology to analyze fourteen library informa- tion systems. Furthermore, research findings and discussions are organized in the following points: type, granularity, boundary, organization and aggrega- tion of object, and representation of information resources, as well as software implementation, social OPAC, software design, operation model, and access.

Hong-Chu Huang; Ya-Ning Chen

2010-01-01

233

Development of a Radioactive Waste Assay System  

Energy Technology Data Exchange (ETDEWEB)

Nuclear Act of Korea requires the manifest of low and intermediate level radioactive waste generated at nuclear power plants prior to disposal sites.Individual history records of the radioactive waste should be contained the information about the activity of nuclides in the drum, total activity, weight, the type of waste. A fully automated nuclide analysis assay system, non-destructive analysis and evaluation system of the radioactive waste, was developed through this research project. For the nuclides that could not be analysis directly by MCA, the activities of the representative {gamma}-emitters(Cs-137, Co-60) contained in the drum were measured by using that system. Then scaling factors were used to calculate the activities of {alpha}, {beta}-emitters. Furthermore, this system can automatically mark the analysis results onto the drum surface. An automated drum handling system developed through this research project can reduce the radiation exposure to workers. (author). 41 refs., figs.

Kang, Duck Won; Song, Myung Jae; Shin, Sang Woon; Sung, Kee Bang; Ko, Dae Hach [Korea Electric Power Research Institute, Taejon (Korea, Republic of); Kim, Kil Jeong; Park, Jong Mook; Jee, Kwang Yoong [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

1996-12-31

234

Development of a PSA information database system  

Energy Technology Data Exchange (ETDEWEB)

The need to develop the PSA information database for performing a PSA has been growing rapidly. For example, performing a PSA requires a lot of data to analyze, to evaluate the risk, to trace the process of results and to verify the results. PSA information database is a system that stores all PSA related information into the database and file system with cross links to jump to the physical documents whenever they are needed. Korea Atomic Energy Research Institute is developing a PSA information database system, AIMS (Advanced Information Management System for PSA). The objective is to integrate and computerize all the distributed information of a PSA into a system and to enhance the accessibility to PSA information for all PSA related activities. This paper describes how we implemented such a database centered application in the view of two areas, database design and data (document) service.

Kim, Seung Hwan [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

2005-07-01

235

Idaho Explosives Detection System: Development and Enhancements  

International Nuclear Information System (INIS)

The Idaho Explosives Detection System (IEDS) was developed at the Idaho National Laboratory (INL) to respond to threats imposed by delivery trucks carrying bulk explosives into military bases. The system consists of two racks, one on each side of a subject vehicle. Each rack includes a neutron generator and an array of sodium iodide (NaI) detectors. The two neutron generators are pulsed and synchronized. A computer connects to the system by Ethernet and is able to control the system remotely. The system was developed to detect bulk explosives in a medium size truck within a 5-minute measurement time. In 2004, a full-scale prototype IEDS system was built for testing and continued development. System performance was successfully tested using different types of real explosives with a variety of cargo at the INL from November 2005 through February 2006. Recently, the first deployable prototype system was constructed and shipped to Wright-Patterson Air Force Base in Ohio and will be in operation by March 2007. The capability of passively detecting radiological material within a delivery truck has also been added

2007-12-01

236

Systems analysis for the development of small resource recovery systems: research and development needs. Final report  

Energy Technology Data Exchange (ETDEWEB)

The technologies that should be developed to make small-scale solid waste processing facilities attractive and viable for small municipalities with solid waste between 50 and 250 tons per day are identified. Research and development needs for refuse derived fuel systems, thermal systems, and biological processes are listed. Selected research and development needs discussed for mechanical processing systems are: develop data bank for low-cost, low-energy shredder options; develop performance data for shredders applied after separation; develop data bank for Trommel performance; and identification and evaluation of low-cost materials separation equipment. Selected research and development needs discussed for thermal systems are: emission levels from solid/waste/to/energy systems; determination of the theoretical efficiencies for thermal processing systems; boiler erosion/corrosion evaluation for systems firing refuse derived fuel; optimization of feed and ash handling systems; refractory life and maintenance requirements; development of 5- to 20-TPD systems; and optimization studies of control systems for small modular incinerators. Selected research and development needs discussed for biological processing systems are: optimum design and operation to maximize gas recovery rates and investigate process configuration alternatives for anaerobic digesters.

Crnkovich, P G; Helmstetter, A J

1980-10-01

237

Universal quantitative kinase assay based on diagonal SCX chromatography and stable isotope dimethyl labeling provides high-definition kinase consensus motifs for PKA and human Mps1.  

UK PubMed Central (United Kingdom)

In order to understand cellular signaling, a clear understanding of kinase-substrate relationships is essential. Some of these relationships are defined by consensus recognition motifs present in substrates making them amendable for phosphorylation by designated kinases. Here, we explore a method that is based on two sequential steps of strong cation exchange chromatography combined with differential stable isotope labeling, to define kinase consensus motifs with high accuracy. We demonstrate the value of our method by evaluating the motifs of two very distinct kinases: cAMP regulated protein kinase A (PKA) and human monopolar spindle 1 (Mps1) kinase, also known as TTK. PKA is a well-studied basophilic kinase with a relatively well-defined motif and numerous known substrates in vitro and in vivo. Mps1, a kinase involved in chromosome segregation, has been less well characterized. Its substrate specificity is unclear and here we show that Mps1 is an acidophilic kinase with a striking tendency for phosphorylation of threonines. The final outcomes of our work are high-definition kinase consensus motifs for PKA and Mps1. Our generic method, which makes use of proteolytic cell lysates as a source for peptide-substrate libraries, can be implemented for any kinase present in the kinome.

Hennrich ML; Marino F; Groenewold V; Kops GJ; Mohammed S; Heck AJ

2013-05-01

238

HAMMER COURSEWARE MANAGEMENT SYSTEM (CMS) SYSTEM DEVELOPMENT & IMPLEMENTATION  

Energy Technology Data Exchange (ETDEWEB)

HAMMER Courseware Management System (HAMMERCMS) is the official name of the system Fluor Hanford, Inc., uses to facilitate development of, deliver, and track training presented in some electronic form (mainly, web-based training) to Hanford Site employees, subcontractors, and vendors.

GARDNER, P.R.

2006-04-28

239

Hydrogen storage and delivery system development  

Energy Technology Data Exchange (ETDEWEB)

Hydrogen storage and delivery is an important element in effective hydrogen utilization for energy applications and is an important part of the FY1994-1998 Hydrogen Program Implementation Plan. The purpose of this project is to develop a platform for the engineering evaluation of hydrogen storage and delivery systems with an added focus on lightweight hydride utilization. Hybrid vehicles represent the primary application area of interest, with secondary interests including such items as existing vehicles and stationary uses. The near term goal is the demonstration of an internal combustion engine/storage/delivery subsystem. The long term goal is optimization of storage technologies for both vehicular and industrial stationary uses. In this project an integrated approach is being used to couple system operating characteristics to hardware development. A model has been developed which integrates engine and storage material characteristics into the design of hydride storage and delivery systems. By specifying engine operating parameters, as well as a variety of storage/delivery design features, hydride bed sizing calculations are completed. The model allows engineering trade-off studies to be completed on various hydride material/delivery system configurations. A more generalized model is also being developed to allow the performance characteristics of various hydrogen storage and delivery systems to be compared (liquid, activated carbon, etc.). Many of the features of the hydride storage model are applicable to the development of this more generalized model.

Handrock, J.L.; Wally, K.; Raber, T.N. [Sandia National Labs., Livermore, CA (United States)

1995-09-01

240

Developments in building-management systems  

Energy Technology Data Exchange (ETDEWEB)

The rise and complexity of modern buildings requires efficient and economic supervision and control. The chief role of the new Building Management system (BMS) is to provide this. This article traces the evolution of BMS over a 25 year period. Prior to highlighting developed computer technology, it examines in detail the earlier Satchwell Autoscan System. After this the developments in minicomputer-based systems with resultant energy conservation are set out to be followed by micro-processing and the distributed intelligence systems dependent on these. Applications and cost savings for the new BMS are exemplified in the London store of Harrods. Bureau systems-maintenance is used for smaller buildings. Costs and savings with the latest BMS (Building Automation systems (BAS)) developments are detailed. The communication requirements for BMS, its implementation and the use of multiple sub-Local Area Networks (LANs) are discussed. Further communication requirements of BMS include developments at the user interface. Finally, the practical problems of managing a modern BMS are followed by a look at possible future trends. (UK).

Clapp, M.D. (Satchwell Control Systems Ltd. (GB))

1989-01-01

 
 
 
 
241

An INTEL 8080 microprocessor development system  

International Nuclear Information System (INIS)

The INTEL 8080 has become one of the two most widely used microprocessors at CERN, the other being the MOTOROLA 6800. Even thouth this is the case, there have been, to date, only rudimentary facilities available for aiding the development of application programs for this microprocessor. An ideal development system is one which has a sophisticated editing and filing system, an assembler/compiler, and access to the microprocessor application. In many instances access to a PROM programmer is also required, as the application may utilize only PROMs for program storage. With these thoughts in mind, an INTEL 8080 microprocessor development system was implemented in the Proton Synchrotron (PS) Division. This system utilizes a PDP 11/45 as the editing and file-handling machine, and an MSC 8/MOD 80 microcomputer for assembling, PROM programming and debugging user programs at run time. The two machines are linked by an existing CAMAC crate system which will also provide the means of access to microprocessor applications in CAMAC and the interface of the development system to any other application. (Auth.)

1977-01-01

242

Information Systems Development Methodolgies in Developing Higher Education  

Directory of Open Access Journals (Sweden)

Full Text Available Studies concerned with the status of Information Systems Development Methodologies usage in many developing countries including the factors that influence and motivate their use, current trends, difficulties, and barriers to adoption are lacking, especially within the higher education sector. This paper examines these identified gaps in a developing country, namely the United Arab Emirates. The initial findings reveal that there is limited knowledge and understanding of the concept of ISDM in federal higher education institutions in the UAE. This is reflected in the quality of the software products being developed and released. However, the analysed data also reveals a trend whereby federal higher education institutions in the UAE are gradually moving towards increased ISDM adoption and deployment.

Adam Marks

2012-01-01

243

Solar energy food dehydration system: Concept development  

Energy Technology Data Exchange (ETDEWEB)

The research activities to be carried out to form the body of this work were planned, first, to increase the general knowledge in the areas of solar energy application and, secondly, to provide sufficient data for the development of a new solar energy powered food dehydrating system. The research work does not aim merely at pursuing the study and development of a new component or a new type of material to be used in the solar industry. But the final and main part of this research is devoted to the development and design of a solar energy system uncharted before the purpose of dehydrating various agricultural products. This proposed solar powered system development is thereby a contribution of technological knowledge to the field of Applied Sciences. It is one of the viable and effective solutions to solving the world's food and energy shortage problem, especially in the less developed regions of the world. The body of this work, thus is divided into three major parts as follows: (1) The search for a thorough understanding of the origin and fundamental characteristics of solar energy. (2) Past and present applications of solar energy. (3) The development and design of a new solar energy powered system for the dehydration of food crops.

Pham, L.V.

1988-01-01

244

Developing Intelligent Transportation Systems in an Integrated Systems Analysis Environment  

Energy Technology Data Exchange (ETDEWEB)

We are working on developing an Integrated Systems Analysis Environment (ISAE) for application to analysis and optimization of Intelligent Transportation Systems (ITS). ISAE is based on the concept of Co-simulation, which allows the modeling of complex systems with extreme flexibility. Co-simulation allows the development of virtual ITS systems that can be analyzed and optimized as an overall integrated system. The virtual ITS system is defined by selecting different components from a component library. System component models can be written in multiple programming languages running on different computer platforms. At the same time, ISAE provides full protection for proprietary models. Co-simulation is a cost-effective alternative to competing methodologies, such as developing a translator or selecting a single programming language for all system components. Co-simulation has been recently demonstrated using an example of an automotive system. The demonstration was successfully performed. The paper describes plans on how to implement ISAE and Co-simulation to ITS, and the great advantages that this implementation would represent.

Aceves, S M; Paddack, E

2002-01-15

245

Solar-Electric Dish Stirling System Development  

Energy Technology Data Exchange (ETDEWEB)

Electrical power generated with the heat from the sun, called solar thermal power, is produced with three types of concentrating solar systems - trough or line-focus systems; power towers in which a centrally-located thermal receiver is illuminated with a large field of sun-tracking heliostats; and dish/engine systems. A special case of the third type of system, a dish/Stirling system, is the subject of this paper. A dish/Stirling system comprises a parabolic dish concentrator, a thermal receiver, and a Stirling engine/generator located at the focus of the dish. Several different dish/Stirling systems have been built and operated during the past 15 years. One system claims the world record for net conversion of solar energy to electric power of 29.4%; and two different company`s systems have accumulated thousands of hours of on-sun operation. Due to de-regulation and intense competition in global energy markets as well as the immaturity of the technology, dish/Stirling systems have not yet found their way into the marketplace. This situation is changing as solar technologies become more mature and manufacturers identify high-value niche markets for their products. In this paper, I review the history of dish/Stirling system development with an emphasis on technical and other issues that directly impact the Stirling engine. I also try to provide some insight to the opportunities and barriers confronting the application of dish/Stirling in power generation markets.

Mancini, T.R.

1997-12-31

246

Progress of the TPS control system development  

International Nuclear Information System (INIS)

The Taiwan Photon Source (TPS) is a low-emittance 3-GeV synchrotron light source that is being built at the National Synchrotron Radiation Research Center (NSRRC) campus. Control system for the TPS is based on EPICS (Experimental Physics and Industrial Control System) framework. Standard hardware and software components have been defined. Prototypes of various subsystems are in implementation. Event based timing system has been adopted. Power supply control interface accompany with orbit feedback support are also defined. Machine protection system is in design phase. Integration with the linear accelerator system which are installed and commissioned at the temporary site for acceptance test has been already done. Interface to various system are still in negotiate stage. Development of the infrastructure of high level and low level software are on going. Progress will be summarized in the report. (authors)

2012-01-01

247

Development of compact CCTV surveillance system 'COSMOS'  

International Nuclear Information System (INIS)

The Compact Surveillance Monitoring System (COSMOS) has been developed as a compact, simple, highly reliable CCTV surveillance system. The system is intended to provide a replacement for the IAEA Twin Minolta Film Camera System. The system consists of a recording unit and a set up/review unit. The recording unit consisting of a CCD camera module, a 8 mm VTR unit, a controller module and a power unit is enclosed in a tamper-indicating housing. The VTR module of very low power consumption is specially designed for COSMOS capable of battery operation. The system can be operated for three months either by battery where mains power is not readily available or by AC powers. The prototype of COSMOS was completed in 1989 and the field-evaluation model will be tested for acceptance at the IAEA from August 1990. (author).

1990-06-07

248

Development of the hypothalamic melanocortin system.  

UK PubMed Central (United Kingdom)

The melanocortin system is a critical component of the forebrain and hindbrain regulatory systems involved in energy balance. This system is composed of pro-opiomelanocortin (POMC) neurons that act, in part, through the melanocortin-4 receptor (MC4R). Although the importance of the melanocortin system in controlling feeding has been established for two decades, the understanding of the developmental substrates underlying POMC and MC4R neuron development and function has just begun to emerge. The formation of the melanocortin system involves several discrete developmental steps that include the birth and fate specification of POMC- and MC4R-containing neurons and the extension and guidance of POMC axons to their MC4R-expressing target nuclei. Each of these developmental processes appears to require specific sets of genes and developmental cues that include perinatal hormones. Recent evidence has also highlighted the importance of perinatal nutrition in controlling the ultimate architecture of the melanocortin system.

Coupe B; Bouret SG

2013-01-01

249

Development of the hypothalamic melanocortin system.  

Science.gov (United States)

The melanocortin system is a critical component of the forebrain and hindbrain regulatory systems involved in energy balance. This system is composed of pro-opiomelanocortin (POMC) neurons that act, in part, through the melanocortin-4 receptor (MC4R). Although the importance of the melanocortin system in controlling feeding has been established for two decades, the understanding of the developmental substrates underlying POMC and MC4R neuron development and function has just begun to emerge. The formation of the melanocortin system involves several discrete developmental steps that include the birth and fate specification of POMC- and MC4R-containing neurons and the extension and guidance of POMC axons to their MC4R-expressing target nuclei. Each of these developmental processes appears to require specific sets of genes and developmental cues that include perinatal hormones. Recent evidence has also highlighted the importance of perinatal nutrition in controlling the ultimate architecture of the melanocortin system. PMID:23543895

Coupe, Berengere; Bouret, Sebastien G

2013-03-27

250

Waste retrieval system development and demonstration  

Energy Technology Data Exchange (ETDEWEB)

Waterjet technologies are being developed and applied to radioactive waste retrieval, processing, and system decontamination. Benefits from this approach include control of waste dilution and dissolution, the ability to clean tank surfaces, and selective removal of surface contaminants. Systems under development include: pulsed air mixers as an alternative to mixer pumps to maintain slurries in suspension; borehole miner with an extendible nozzle as an enhancement of sluicing; confined sluicing end effector with jet pump retrieval for breakup and removal of sludges and solids; and scarifier with pneumatic conveyance for fracture and removal of sludges and harder solids without water accumulation or appreciable waste dilution and surface decontamination. Two systems are being developed for demonstration in radioactive tanks in Fiscal Year 1997: the confined sluicing end effector for retrieval of waste from tanks W3 and W4 at Oak Ridge National Laboratory and extendible nozzle for zeolite, heel breakup at Savannah River Site tank 19.

Bamberger, J.A.; Rinker, M.W. [Pacific Northwest National Lab., Richland, WA (United States)

1996-12-31

251

Waste retrieval system development and demonstration  

International Nuclear Information System (INIS)

Waterjet technologies are being developed and applied to radioactive waste retrieval, processing, and system decontamination. Benefits from this approach include control of waste dilution and dissolution, the ability to clean tank surfaces, and selective removal of surface contaminants. Systems under development include: pulsed air mixers as an alternative to mixer pumps to maintain slurries in suspension; borehole miner with an extendible nozzle as an enhancement of sluicing; confined sluicing end effector with jet pump retrieval for breakup and removal of sludges and solids; and scarifier with pneumatic conveyance for fracture and removal of sludges and harder solids without water accumulation or appreciable waste dilution and surface decontamination. Two systems are being developed for demonstration in radioactive tanks in Fiscal Year 1997: the confined sluicing end effector for retrieval of waste from tanks W3 and W4 at Oak Ridge National Laboratory and extendible nozzle for zeolite, heel breakup at Savannah River Site tank 19.

1996-01-01

252

Feedwater system diagnostic development using distributed simulation  

Energy Technology Data Exchange (ETDEWEB)

A real-time diagnostic system for the EBR-II steam plant has been developed using the DISYS Diagnostic and Control Guidance Expert System. Diagnostic rules were developed to distinctly identify ten specific fault conditions and were tested using a real-time distributed simulation of the EBR-II steam plant. The distributed simulation is implemented in three separate programs in a VAX cluster and is coordinated through a distributed simulation manager operating in a UNIX workstation. The multi-program DISYS system currently operates in the same UNIX workstation as the simulation manager and obtains the simulated data from a shared memory segment maintained by the simulation manager. Future work includes modifying the DISYS system to improve the fault detection of rapid transients and enable it to detect gradual long term trends.

Walters, P.B.; Edwards, R.M.; Turso, J.A.; Garcia, H.E.

1992-12-31

253

Development of nuclear material accountancy control system  

International Nuclear Information System (INIS)

PNC is developing a wide area of nuclear fuel cycle. Therefore, much nuclear material with a various form exists at each facility in the Works, and the controls of the inventory changes and the physical inventories of nuclear material are important. Nuclear material accountancy is a basic measure in safeguards system based on Non-Proliferation Treaty (NPT). In the light of such importance of material accountancy, the data base of nuclear material control and the material accountancy report system for all facilities has been developed by using the computer. By this system, accountancy report to STA is being presented certainly and timely. Property management and rapid corresponding to various inquiries can be carried out by the data base system which has free item searching procedure. (author).

1992-01-01

254

Hydrogen storage and delivery system development: Analysis  

Energy Technology Data Exchange (ETDEWEB)

Hydrogen storage and delivery is an important element in effective hydrogen utilization for energy applications and is an important part of the FY1994-1998 Hydrogen Program Implementation Plan. This project is part of the Field Work Proposal entitled Hydrogen Utilization in Internal Combustion Engines (ICE). The goal of the Hydrogen Storage and Delivery System Development Project is to expand the state-of-the-art of hydrogen storage and delivery system design and development. At the foundation of this activity is the development of both analytical and experimental evaluation platforms. These tools provide the basis for an integrated approach for coupling hydrogen storage and delivery technology to the operating characteristics of potential hydrogen energy use applications. Results of the analytical model development portion of this project will be discussed. Analytical models have been developed for internal combustion engine (ICE) hybrid and fuel cell driven vehicles. The dependence of hydride storage system weight and energy use efficiency on engine brake efficiency and exhaust temperature for ICE hybrid vehicle applications is examined. Results show that while storage system weight decreases with increasing engine brake efficiency energy use efficiency remains relatively unchanged. The development, capability, and use of a recently developed fuel cell vehicle storage system model will also be discussed. As an example of model use, power distribution and control for a simulated driving cycle is presented. Model calibration results of fuel cell fluid inlet and exit temperatures at various fuel cell idle speeds, assumed fuel cell heat capacities, and ambient temperatures are presented. The model predicts general increases in temperature with fuel cell power and differences between inlet and exit temperatures, but under predicts absolute temperature values, especially at higher power levels.

Handrock, J.L. [Sandia National Labs., Livermore, CA (United States)

1996-10-01

255

The development of the Finnish energy system  

Energy Technology Data Exchange (ETDEWEB)

The development of the Finnish energy system since the first oil crisis has been both economically and technically well balanced, mainly because of a successful and active energy policy as well as carefully planned responses to external driving forces. The production and distribution system is up-to-date and technologically advanced, supplying good quality energy with high efficiency and at competitive prices. Many economical and technical indicators compare well with ELT and OECD average values.

Kara, M.; Tuhkanen, S.

2002-07-01

256

Systems-based discovery advances drug development.  

UK PubMed Central (United Kingdom)

Drug development expenditures continue to escalate, in part reflecting inefficiencies in current drug discovery paradigms. Traditional drug discovery has been dichotomous, focusing either on phenotypic effects of distinct agents in biological systems, without knowledge of respective targets, or on target-based activities of specific molecules in cell-free assays. Driven by advances in biology, engineering, and informatics, new paradigms integrate phenotypic with target-based algorithms into comprehensive, systems-level approaches offering value-added strategies for optimized drug discovery.

Waldman SA; Terzic A

2013-04-01

257

The SLC control system - status and development  

Energy Technology Data Exchange (ETDEWEB)

The SLC control system is installed and operational in the full SLC through the Linac, Damping Rings, Positron Source, Arcs and Final Focus. The system now includes a host VAX 11/785, a development VAX 11/780, 4 VAX workstations, a distributed network of 70 microprocessors, and about 270 Camac crates with more than 4000 modules. The micros are used for control and monitoring of the hardware, for pulse-to-pulse feedback, and for consoles (COWs). High level model-driven host software provides a variety of tools for beam setup, optimization, diagnosis, and stabilization. This paper will summarize the current status and projects under development.

Phinney, N.; Shoaee, H.

1987-03-01

258

Development of an automatic reactor inspection system  

International Nuclear Information System (INIS)

Using recent technologies on a mobile robot computer science, we developed an automatic inspection system for weld lines of the reactor vessel. The ultrasonic inspection of the reactor pressure vessel is currently performed by commercialized robot manipulators. Since, however, the conventional fixed type robot manipulator is very huge, heavy and expensive, it needs long inspection time and is hard to handle and maintain. In order to resolve these problems, we developed a new automatic inspection system using a small mobile robot crawling on the vertical wall of the reactor vessel. According to our conceptual design, we developed the reactor inspection system including an underwater inspection robot, a laser position control subsystem, an ultrasonic data acquisition/analysis subsystem and a main control subsystem. We successfully carried out underwater experiments on the reactor vessel mockup, and real reactor ready for Ulchine nuclear power plant unit 6 at Dusan Heavy Industry in Korea. After this project, we have a plan to commercialize our inspection system. Using this system, we can expect much reduction of the inspection time, performance enhancement, automatic management of inspection history, etc. In the economic point of view, we can also expect import substitution more than 4 million dollars. The established essential technologies for intelligent control and automation are expected to be synthetically applied to the automation of similar systems in nuclear power plants.

2002-01-01

259

Development of an omnidirectional vision system  

Scientific Electronic Library Online (English)

Full Text Available Abstract in english Omnidirectional vision systems can provide images with a 360° of field of view. For this reason, they can be useful to robotic applications such as navigation, teleoperation and visual servoing. An effective way to construct this type of vision system is by combining lenses and mirrors together resulting on a system that does not require the movement of the camera to the direction of attention of the robot. A typical construction is by mounting a convex mirror in fron (more) t of a camera aligning the center of the mirror with the optical axis of the camera. The most common convex mirror shapes used are conic, parabolic, hyperbolic and spherical. In this work we present two types of mirror that were constructed: a spherical mirror, used in the initial tests, and a hyperbolic, used for actual robot tasks. The hyperbolic mirror was manufactured using an ultra-precision CNC machine. Additionally, a software was developed to create panoramic and perspective images from the image acquired by the system. This work shows the development of an omnidirectional vision system, presenting the formulation used to determine a suitable mirror shape, the mechanical solutions used to build a fully operational system, and the results of the developed algorithm.

Grassi Junior, Valdir; Okamoto Junior, Jun

2006-03-01

260

Some problems in large superconducting system development  

International Nuclear Information System (INIS)

[en] The experience in developments of large superconducting magnetic systems (SMS) for investigations into controlled fusion, accumulated in the Kurchatov Institute of Atomic Energy, is analyzed. The early operating SMS of the immersion and circulation type are described. The specifications of SMS being developed are presented. The advantages of circulation-type devices over the immersion-type ones are demostrated. The prospects for use of SMS on multistrand intermetallic materials are briefly outlined

1975-09-19

 
 
 
 
261

Development of KSTAR Neutral Beam Heating System  

International Nuclear Information System (INIS)

The prototype components of a neutral beam injection (NBI) system have been developed for the KSTAR, and a capability of the manufactured components has been tested. High power ion source, acceleration power supply, other ion source power supplies, neutralizer, bending magnet for ion beam separation, calorimeter, and cryo-sorption pump have been developed by using the domestic technologies and tested for a neutral beam injection of 8 MW per beamline with a pulse duration of 300 seconds. The developed components have been continuously upgraded to achieve the design requirements. The development technology of high power and long pulse neutral beam injection system has been proved with the achievement of 5.2 MW output for a short pulse length and 1.6 MW output for a pulse length of 300 seconds. Using these development technologies, the domestic NB technology has been stabilized under the development of high power ion source, NB beamline components, high voltage and current power supplies, NB diagnostics, NB system operation and control.

2007-01-01

262

Development of automatic laser welding system  

International Nuclear Information System (INIS)

Laser are a new production tool for high speed and low distortion welding and applications to automatic welding lines are increasing. IHI has long experience of laser processing for the preservation of nuclear power plants, welding of airplane engines and so on. Moreover, YAG laser oscillators and various kinds of hardware have been developed for laser welding and automation. Combining these welding technologies and laser hardware technologies produce the automatic laser welding system. In this paper, the component technologies are described, including combined optics intended to improve welding stability, laser oscillators, monitoring system, seam tracking system and so on. (author)

2002-01-01

263

Development of SAXS DAQ system at SSRF  

International Nuclear Information System (INIS)

Development of the data acquisition (DAQ) system based on Lab VIEW platform for small angle X-ray scattering (SAXS) at Shanghai Synchrotron Radiation Facility (SSRF) is introduced in this paper. Experimental parameter setting of the gas detectors and ionizing-chambers, data acquisition and saving were realized with the Lab VIEW platform.The system was tested with 10 keV X-ray from the SSRF storage ring running 10 mA beams, and the test results verified the validity and integrity of this system. (authors)

2009-01-01

264

Development of an Autonomous Pathogen Detection System  

Energy Technology Data Exchange (ETDEWEB)

An Autonomous Pathogen Detection System (APDS) is being designed and evaluated for use in domestic counter-terrorism. The goal is a fully automated system that utilizes both flow cytometry and polymerase chain reaction (PCR) to continuously monitor the air for BW pathogens in major buildings or high profile events. A version 1 APDS system consisting of an aerosol collector, a sample preparation subsystem, and a flow cytometer for detecting the antibody-labeled target organisms has been completed and evaluated. Improved modules are under development for a version 2 APDS including a Lawrence Livermore National Laboratory-designed aerosol preconcentrator, a multiplex flow cytometer, and a flow-through PCR detector.

Langlosi, S.; Brown, S.; Colston, B.; Jones, L.; Masquelier, D.; Meyer, P.; McBride, M.; Nasarabad, S.; Ramponi, A.J.; Venkatseswarm, K.; Milanovich, F.

2000-10-12

265

Development of liquid propulsion systems in ISRO  

Energy Technology Data Exchange (ETDEWEB)

A development history is presented for ISRO's monopropellant and bipropellant liquid-fuel rocket propulsion systems. These have included bipropellant engines employing hypergolic propellants and ablative chambers that have been employed as both single stages and multistage system sustainer stages. The monopropellant thrusters have found application in reaction-control systems for satellites and launch vehicles. Currently, film-cooled, regeneratively-cooled, and radiation-cooled engines are undergoing tests for application aboard the Polar Satellite Launch Vehicle, as well as for apogee propulsion of the Insat-II.

Muthunayagam, A.E.

1988-01-01

266

DEVELOPMENT OF INTELLIGENT SECURITY AND AUTOMATION SYSTEM  

Directory of Open Access Journals (Sweden)

Full Text Available Intelligent security and Automation system is a device that intends to solve the security issues and also provides automation facilities. the two aspects of security and automation are distinguished by a selector switch. the goal is to develop an intelligent security & automation system that gives the user complete security and automation services. this system can work in two modes as indoor mode and outdoor mode. in outdoor mode it provides complete security of the user place and in indoor mode, it provides user help and automation services. in indoor mode, it helps user as energy consumption indicator, light and temperature controller, home appliances controller, automatic door bell indicator

Diwakar Saxena, Puneet Bisen, Shashank Bhoyerkar

2012-01-01

267

Development of an optimized disturbance detection system  

International Nuclear Information System (INIS)

An optimized disturbance detection system for BWR power plants was developed aiming to mitigate information overload for operators. To optimize the amount of information for disturbance detection, efforts are focused on handling of alarms. The functions of the system are to extract relevant alarms out of the large number of alarms in the control room and to provide the operators a clear overview of the process status. The constituent methodologies for alarm handlings are realized by using logical expression and implemented to a process computer. The test results of the system by using a full-scope BWR plant simulator are quite satisfactory. (author).

1986-01-01

268

Development of nuclear safety information retrieval system  

International Nuclear Information System (INIS)

An on-line information retrieval system for quickly analyzing safety-related informations in nuclear power plants has been developed. By analyzing and evaluating the operating experience/failure reports it is shown that the system is a convenient tool in considering to have the availability of nuclear plants increased. The system may also be used for a variety of purposes. For example, it is useful as a data base for evaluation of the component reliability or for taking measures to meet the various failure situation of the nuclear plants. (author)

1978-01-01

269

Development of Testing Environment for Embedded Systems  

Directory of Open Access Journals (Sweden)

Full Text Available Quality is the life of embedded systems, and thetesting is a basic guarantee for stable and reliable operation ofthe embedded systems. Testing is an important part in thedevelopment of any system as it represents the ultimateverification and validation of specification, design and code.The goal of testing is to design a series of test cases that has thehighest likelihood of finding most of the errors with a minimumamount of time and effort. The techniques used to test theembedded systems provide systematic guidance for designingtests that exercise the internal logic of Embedded Systemcomponents and test the input and output domains of theprogram to uncover errors in program function, behavior andperformance. Simulation can be used as an alternative to theactual target system for a significant portion of the testingeffort, saving developers time and money, as well as increasingtest coverage and providing better debugging facilities, itbecomes much more necessary to construct embedded systemstesting environment.

Miss. Ashwini M. Motghare, Prof. Swapnili P. Karmore

2012-01-01

270

Kentucky's Statewide Early Childhood Professional Development System  

Science.gov (United States)

Public school systems have recently become major players in providing services for children in their early years. In addition, a number of other services are available to young children including child care, Head Start, and Early Head Start programs. The link between program quality and professional development of early care and education…

Rous, Beth; Grove, Jaime; Townley, Kim

2007-01-01

271

Mobile Systems Development: An Empirical Study  

Digital Repository Infrastructure Vision for European Research (DRIVER)

As part of an ongoing study on mobile systems development (MSD), this paper presents preliminary findings of research-in-progress. The debate on mobility in research has so far been dominated by mobile HCI, technological innovations, and socio-technical issues related to new and emerging mobile work...

Hosbond, J. H.

272

Air Force Civilian Potential Appraisal System: Development.  

Science.gov (United States)

An appraisal system for use by the Air Force in ranking competitive position civilian promotion eligibles was developed to meet legal and operational requirements. Demographic data and supervisor and peer ratings were obtained from a 20,000 case target sa...

D. E. Black R. B. Gould W. H. Cummings

1984-01-01

273

Air Force Civilian Promotion Appraisal System Development.  

Science.gov (United States)

A system for ranking civilian promotion eligibles was developed to meet legal and operational requirements. Demographic data and supervisor and peer ratings were obtained on a 20,000 case target sample to establish a pool of potential ranking elements. Va...

R. B. Gould

1981-01-01

274

Development of a chemical gas sensor system  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The main achievement of this work was the development of a chemical gas sensor system for two relevant environmental applications: indoor (carbon monoxide and methane) and outdoor (carbon monoxide and nitrogen dioxide) monitoring of pollutants. Towards this end, three subsequent tasks were accomplis...

Reichel, Patrick

275

Developing innovative systems for reinforced masonry walls  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The Commission of the European Communities has recently funded a CRAFT research project aimed at developing innovative systems for load and non-load-bearing reinforced masonry walls. The project involves twelve partners coming from four different European countries, among which there are universitie...

Mosele, F.; Porto, F. da; Modena, C.; Fusco, A. di; Cesare, G. di; Vasconcelos, Graça; Haach, V.; Lourenço, Paulo B.

276

Health care system reform in developing countries  

Digital Repository Infrastructure Vision for European Research (DRIVER)

This article proposes a critical but non-systematic review of recent health care system reforms in developing countries. The literature reports mixed results as to whether reforms improve the financial protection of the poor or not. We discuss the reasons for these differences by comparing three rep...

Wei Han

277

Developing a solar panel testing system  

Directory of Open Access Journals (Sweden)

Full Text Available Solar energy is increasingly used togenerate electricity for individual households. There isa wide variety of solar panel technologies, whichshould be tested at an individual level during theirlifetime. In this paper, the development of a testingstation at the University of Debrecen is presented. Thetesting system can be used for research andeducational purposes and for in field applicationsequally well.

Árpád Rácz; István A. Szabó; Lajos Harasztosi; Sándor Kökényesi

2009-01-01

278

Development of an advanced robot manipulator system  

International Nuclear Information System (INIS)

A sophisticated manipulator system for an advanced robot was developed under the 'Advanced Robot Technology Development' Program promoted and supported by the Agency of Industrial Science and Technology of MITI. The authors have participated in the development of a fingered manipulator with force and tactile sensors applicable to a masterslave robot system. Our slave manipulator is equipped with four fingers. Though the finger needs many degrees of freedom so as to be suitable for skilful handing of an object, our fingers are designed to have minimum degree of freedom in order to reduce weight. Each finger tip was designed to be similar to a human finger which has flexibility, softness and contact feeling. The shape of the master finger manipulator was so designed that the movement of the fingers is smoother and that the constraint feeling of the operator is smaller. We were adopted to a pneumatic pressure system for transmitting the tactile feeling of the slave fingers to the master fingers. A multiple sensory bilateral control system which gives an operator a feeling of force and tactile reduces his feeling of constraint in carrying out work with a robot system. (author).

1991-01-01

279

Research and Development Management System (RDMS)  

International Nuclear Information System (INIS)

[en] Research and Development (R and D) is a main activity carried out at the Malaysian Nuclear Agency particularly in the physical science and nuclear field. The R and D activity that is carried out needs to be managed more efficiently and systematically. Until now all research management activities are carried out manually or semi electronically, beginning from filling in application forms to when the project is completed. Therefore a computerized system is needed in order to manage and monitor R and D projects. The R and D system is capable of giving access information concerning R and D projects which are carried out to users inside and outside the agency. The R and D management system (RDMS) can increase the capability of the Malaysian Nuclear Agency in managing, researching and developing, innovating and inventing technology as well as commercializing the R and D produced. (author)

2010-01-01

280

Development of radiation detection and measurement systems  

Energy Technology Data Exchange (ETDEWEB)

This report contains descriptions on the following six items. The first item is the result of a study on CsI(TI) crystals with their light emitting characteristics and the result of a study on plastic scintillators. The second item is the result of a study on advanced radiation detectors and includes experiments for the effect of using a Compton suppressor with an HPGe detector. For the third item, we describe the results of a design work done using EGS4 for a thickness gauge, a density gauge, and a level gauge. The fourth item contains descriptions on the prototype circuit systems developed for a level gauge, a thickness gauge, and for a survey meter. The fifth part contains the computed tomography algorithm and a prototype scanning system developed for a CT system. As the sixth and the last item, we describe the prototype high precision heat source and the prototype heat-voltage converter which we have designed and fabricated.

Moon, B. S.; Ham, C. S.; Chung, C. E. and others

2000-03-01

 
 
 
 
281

[Develop mine communications system]. Final technical report  

Energy Technology Data Exchange (ETDEWEB)

The objective of this project was to develop, design, and build a system prototype to demonstrate the practicality of two-way, wireless through-the-earth communications between the interior of a mine and the surface. The system was to communicate data for process and environment monitoring and control, and provide real-time voice communication for emergency situations and for daily operations use. Transmitters and receivers were designed, built, and tested in actual mines. A wireless in-mine communications system was also developed. The feasibility of the concept and the marketability of the product were successfully demonstrated. Additional work must be done to make the product suitable for, and marketable to, the coal mining industry.

Meiksin, Z.H.

1998-09-15

282

Advanced CIDI Emission Control System Development  

Energy Technology Data Exchange (ETDEWEB)

Ford Motor Company, with ExxonMobil and FEV, participated in the Department of Energy's (DOE) Ultra-Clean Transportation Fuels Program with the goal to develop an innovative emission control system for light-duty diesel vehicles. The focus on diesel engine emissions was a direct result of the improved volumetric fuel economy (up to 50%) and lower CO2 emissions (up to 25%) over comparable gasoline engines shown in Europe. Selective Catalytic Reduction (SCR) with aqueous urea as the NOx reductant and a Catalyzed Diesel Particulate Filter (CDPF) were chosen as the primary emission control system components. The program expected to demonstrate more than 90% durable reduction in particulate matter (PM) and NOx emissions on a light-duty truck application, based on the FTP-75 drive cycle. Very low sulfur diesel fuel (<15 ppm-wt) enabled lower PM emissions, reduced fuel economy penalty due to the emission control system and improved long-term system durability. Significant progress was made toward a durable system to meet Tier 2 Bin 5 emission standards on a 6000 lbs light-duty truck. A 40% reduction in engine-out NOx emissions was achieved with a mid-size prototype diesel engine through engine recalibration and increased exhaust gas recirculation. Use of a rapid warm-up strategy and urea SCR provided over 90% further NOx reduction while the CDPF reduced tailpipe PM to gasoline vehicle levels. Development work was conducted to separately improve urea SCR and CDPF system durability, as well as improved oxidation catalyst function. Exhaust gas NOx and ammonia sensors were also developed further. While the final emission control system did not meet Tier 2 Bin 5 NOx after 120k mi of aging on the dynamometer, it did meet the standards for HC, NMOG, and PM, and an improved SCR catalyst was shown to have potential to meet the NOx standard, assuming the DOC durability could be improved further. Models of DOC and SCR function were developed to guide the study of several key design factors for SCR systems and aid in the development of urea control strategy for maximum NOx reduction with minimum NH3 slip. A durable co-fueling system was successfully built and tested, with the help of service station nozzle and dispenser manufacturers, for simultaneous delivery of diesel fuel and aqueous urea to the vehicle. The business case for an aqueous urea infrastructure in the US for light-duty vehicles was explored.

Lambert, Christine

2006-05-31

283

A microprocessor system for testing, calculating and regulating the parameters of a city gas main sector. Mikroprotsessornaya sistema kontrolya, ucherta i regulirovaniya parametrov uchastka gazovoy seti goroda  

Energy Technology Data Exchange (ETDEWEB)

An algorithm is described for the operation of a microprocessor system (MPS). A justification is conducted, along with a selection of microprocessor large integrated circuits (BIS) for building the microcontroller of the system. The basic design and technical decisions are developed and proposed for building a multiprocessor system at the level of structural and functional layouts both for the system as a whole, and its individual parts. It is shown that the creation of an automated industrial process control system (ASU TP) for gas supply to cities on the basis of the multiprocessor system substantially increases its reliability, the operational precision and reduces cost and dimensions.

Berezanskiy, R.T.; Menyaylo, V.A.; Pavlovskiy, B.M.

1982-01-01

284

Controls system developments for the ERL facility  

Energy Technology Data Exchange (ETDEWEB)

The BNL Energy Recovery LINAC (ERL) is a high beam current, superconducting RF electron accelerator that is being commissioned to serve as a research and development prototype for a RHIC facility upgrade for electron-ion collision (eRHIC). Key components of the machine include a laser, photocathode, and 5-cell superconducting RF cavity operating at a frequency of 703 MHz. Starting with a foundation based on existing ADO software running on Linux servers and on the VME/VxWorks platforms developed for RHIC, we are developing a controls system that incorporates a wide range of hardware I/O interfaces that are needed for machine R&D. Details of the system layout, specifications, and user interfaces are provided.

Jamilkowski, J.; Altinbas, Z.; Gassner, D.; Hoff, L.; Kankiya, P.; Kayran, D.; Miller, T.; Olsen, R.; Sheehy, B.; Xu, W.

2011-10-07

285

Development of compact CCTV surveillance system. `COSMOS`  

Energy Technology Data Exchange (ETDEWEB)

The Compact Surveillance and Monitoring System, `COSMOS` has been developed as a compact, simple, highly reliable CCTV surveillance system. The system is intended to provide a direct replacement for the IAEA Twin Minolta film camera systems. The system consists of a recording unit and a set up/review unit. The recording unit, consisting of a CCD camera module, a 8mm VTR unit, a controller module and a power unit, is contained in a tamper indicating housing. The VTR module of very low power consumption is specially developed for COSMOS capable of battery operation. The system can be operated for three months either by battery without battery change where mains power is not readily available or by AC powers. The field-use model of COSMOS was completed in 1991. The field-evaluation test by the IAEA and JAERI was successfully completed in 1993. The IAEA accepted the COSMOS as a routine-use device in August 1993. This report describes the performance features and IAEA test result of COSMOS. (author).

Mukaiyama, Takehiko; Ogawa, Hironobu [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

1993-12-31

286

Development of compact CCTV surveillance system. 'COSMOS'  

International Nuclear Information System (INIS)

The Compact Surveillance and Monitoring System, 'COSMOS' has been developed as a compact, simple, highly reliable CCTV surveillance system. The system is intended to provide a direct replacement for the IAEA Twin Minolta film camera systems. The system consists of a recording unit and a set up/review unit. The recording unit, consisting of a CCD camera module, a 8mm VTR unit, a controller module and a power unit, is contained in a tamper indicating housing. The VTR module of very low power consumption is specially developed for COSMOS capable of battery operation. The system can be operated for three months either by battery without battery change where mains power is not readily available or by AC powers. The field-use model of COSMOS was completed in 1991. The field-evaluation test by the IAEA and JAERI was successfully completed in 1993. The IAEA accepted the COSMOS as a routine-use device in August 1993. This report describes the performance features and IAEA test result of COSMOS. (author).

1993-01-01

287

Development of Intellectual Reactor Design System: IRDS  

International Nuclear Information System (INIS)

In the frame of the new theme 'Study of analysis method of new nuclear power systems' admitted in our Reactor system laboratory since FY 1988, a program to develop the Intellectual Reactor Design System (IRDS) in the same spirit as ADES has been established. This report describes the activities related to IRDS performed in FY 1989. One of major activities is drafting IRDS. It reflects the conclusion of the STA ADES committee. The essence is to construct a modular system under the object-oriented programming environment to provide a conversational tool for feasibility study and conceptual design. Along the draft the following items were executed in the FY. For the realization of the conversational tool, a tool for input data generation by an object-oriented programming and another tool like CAD for geometry input data generation by a conversational processing of figures on display were examined. Upon the study how to construct the object-oriented data base, the class and frame structures of the design data base were drafted. As components of the modular system, programming of a neutronics and a thermohydraulics module for feasibility study was started. Also a structure analysis code was studied for conversion. In the coming FY, the computer system which has been composed by a FACOM host machine and terminals or isolated PCs will be exchanged by a SUN work-station linked with the host machine and PCs by an ETHER network. Under the suitable environment, the development of IRDS will be promoted. (author).

1990-01-01

288

Development of an Integrated Distribution Management System  

Energy Technology Data Exchange (ETDEWEB)

This final report details the components, functionality, costs, schedule and benefits of developing an Integrated Distribution Management System (IDMS) for power distribution system operation. The Distribution Automation (DA) and Supervisory Control and Data Acquisition (SCADA) systems used by electric power companies to manage the distribution of electric power to retail energy consumers are vital components of the Nation’s critical infrastructure. Providing electricity is an essential public service and a disruption in that service, if not quickly restored, could threaten the public safety and the Nation’s economic security. Our Nation’s economic prosperity and quality of life have long depended on the essential services that utilities provide; therefore, it is necessary to ensure that electric utilities are able to conduct their operations safely and efficiently. A fully integrated technology of applications is needed to link various remote sensing, communications and control devices with other information tools that help guide Power Distribution Operations personnel. A fully implemented IDMS will provide this, a seamlessly integrated set of applications to raise electric system operating intelligence. IDMS will enhance DA and SCADA through integration of applications such as Geographic Information Systems, Outage Management Systems, Switching Management and Analysis, Operator Training Simulator, and other Advanced Applications, including unbalanced load flow and fault isolation/service restoration. These apps are capable of utilizing and obtaining information from appropriately installed DER, and by integrating disparate systems, the Distribution Operators will benefit from advanced capabilities when analyzing, controlling and operating the electric system.

Schatz, Joe E.

2010-10-20

289

Development of a digital mammography system  

International Nuclear Information System (INIS)

[en] A digital breast imaging system is under development to provide improved detectability of breast cancer. In previous work, the limitations of screen-film mammography were studied using both theoretical and experimental techniques. Important limitations were found in both the acquisition and the display components of imaging. These have been addressed in the design of a scanned-projection digital mammography system. A high resolution x-ray image intensifier (XRII), optically coupled to a self-scanned linear photodiode array, is used to record the image. Pre- and post-patient collimation virtually eliminates scattered radiation and veiling glare of the XRII with only a 20% increase in dose due to penumbra. Geometric magnification of 1.6 times is employed to achieve limiting spatial resolution of 7 lp/mm. For low-contrast objects as small as 0.1 mm in diameter, the digital system is capable of producing images with higher contrast and signal-to-noise ratio than optimally-exposed conventional film-screen mammography systems. Greater latitude is obtainable on the digital system because of its wide dynamic range and linearity. The slit system is limited due to long image acquisition times, and poor quantum efficiency. This motivated the authors' current work on a slot beam digital mammography system which is based on a fiber-optic x-ray detector. Preliminary results of this system are presented

1988-02-05

290

Advanced Turbine Systems Program industrial system concept development  

Energy Technology Data Exchange (ETDEWEB)

The objective of Phase II of the Advanced Turbine Systems Program is to develop conceptual designs of gas fired advanced turbine systems that can be adapted for operation on coal and biomass fuels. The technical, economic, and environmental performance operating on natural gas and in a coal fueled mode is to be assessed. Detailed designs and test work relating to critical components are to be completed and a market study is to be conducted.

Gates, S. [Solar Turbines Inc., San Diego, CA (United States)

1995-10-01

291

Information system development activities and inquiring systems : an integrating framework  

DEFF Research Database (Denmark)

This article presents a framework that maps information system development (ISD) activities on systems for the creation of knowledge. This work addresses the relevant and persisting problem of improving the chances of ISD success. The article builds upon previous research on knowledge aspects of ISD, abandoning the idea of a monolithic approach to knowledge and presenting a pluralistic approach based on the idea that different inquiring systems can support micro-level ISD activities. The article is divided into two parts. The first part presents the theoretical development of the framework based on ISD literature and on Churchman's (1971) inquiring systems. The second part presents the use of the framework in an ISD project. The case is used to show the applicability of the framework and to highlight the advantages of this approach. The main theoretical implication is that the framework provides a new way to see the development of a system in terms of the knowledge created in the process. The main practical implication of the framework is that it improves the managers' ability to guide ISD activities as knowledge activities embedded in a knowledge process, a crucial element in development projects. Udgivelsesdato: APR

Carugati, Andrea

2008-01-01

292

Development of Korea Operational Oceanographic System (KOOS)  

Science.gov (United States)

Korea Operational Oceanographic System (KOOS) is a research project funded by the Minister of Land, Transport and Maritime Affairs (MLTM) in Korea and the goal of this project is to develop an integrated operational oceanographic system that will provide nowcasts and forecasts of ocean information around Korean Peninsula to support marine activities for governmental agencies and to mitigate coastal disasters such as storm surge, oil spill, and search and rescue. Since August 2009, KIOST has been leading the project to develop KOOS, which consists of three parts, 1) observing systems, 2) numerical modeling with data management and skill assessment, and 3) practical application systems. In KOOS about 190 real-time coastal/ocean observing platforms such as tidal stations, buoys, off-shore research stations and satellites from various agencies, KIOST, KHOA (Korea Hydrographic and Oceanographic Administration), NFRDI (National Fisheries Research & Development Institute), and KMA (Korea Meteorological Administration) have been used for input data as well as calibration and validation for numerical models. With observing networks, various atmospheric models and ocean models have been set-up and tested. KOOS enables us to forecast tides, waves, storm surges, currents as well as temperature and salinity for 72-hour time period in two time a day. The performance of numerical models is evaluated by the skill assessment system. For practical purposes, KOOS has various application systems such as storm surge, search and rescues, oil spill, and ports and channel prediction system. All ocean information in KOOS is to be presented via web-based GIS, which is an effective tool that is helpful to decision-makers.

Park, Kwang Soon; Jun, Ki Cheon; Lee, Jong Chan; Kwon, Jae Il; Cho, Kyung Ho; Choi, Jung Woon; Kim, Sung Dae; Kim, Jin Ah; Kim, Sang Ik; Kim, Yong Ho; Choi, Byung Ju

2013-04-01

293

EXPERT SYSTEMS - DEVELOPMENT OF AGRICULTURAL INSURANCE TOOL  

Directory of Open Access Journals (Sweden)

Full Text Available Because of the fact that specialty agricultural assistance is not always available when the farmers need it, we identified expert systems as a strong instrument with an extended potential in agriculture. This started to grow in scale recently, including all socially-economic activity fields, having the role of collecting data regarding different aspects from human experts with the purpose of assisting the user in the necessary steps for solving problems, at the performance level of the expert, making his acquired knowledge and experience available. We opted for a general presentation of the expert systems as well as their necessity, because, the solution to develop the agricultural system can come from artificial intelligence by implementing the expert systems in the field of agricultural insurance, promoting existing insurance products, farmers finding options in depending on their necessities and possibilities. The objective of this article consists of collecting data about different aspects about specific areas of interest of agricultural insurance, preparing the database, a conceptual presentation of a pilot version which will become constantly richer depending on the answers received from agricultural producers, with the clearest exposure of knowledgebase possible. We can justify picking this theme with the fact that even while agricultural insurance plays a very important role in agricultural development, the registered result got from them are modest, reason why solutions need to be found in the scope of developing the agricultural sector. The importance of this consists in the proposal of an immediate viable solution to correspond with the current necessities of agricultural producers and in the proposal of an innovative solution, namely the implementation of expert system in agricultural insurance as a way of promoting insurance products. Our research, even though it treats the subject at an conceptual level, it wants to undertake an attempt to present the necessity and importance of implementing expert systems in agricultural insurance as a solution of development of the Romanian agricultural sector since insurance play an important role in the stimulation of investments in agriculture and in the stabilization of agricultural producers incomes. The results of the study, at a conceptual level, confirms the necessity of aplying expert systems in agricultural insurance because of the benefits which would be created (informing agricultural producers about the existence and importance of agricultural insurance, the development of the insurance market which would lead to the development of agriculture, creation of new insurance products adapted to the needs of the farmers).

NAN Anca-Petru?a; MOISUC Diana-Aderina

2013-01-01

294

Oral health care systems in developing and developed countries.  

UK PubMed Central (United Kingdom)

Health care systems are essential for promoting, improving and maintaining health of the population. Through an efficient health service, patients can be advised of disease that may be present and so facilitate treatment; risks factors whose modification could reduce the incidence of disease and illness in the future can be identified, and further, how controlling such factors can contribute to maintain a good quality of life. In developed countries, clinics or hospitals may be supported by health professionals from various specialties that allow their cooperation to benefit the patient; these institutions or clinics may be equipped with the latest technical facilities. In developing countries, health services are mostly directed to provide emergency care only or interventions towards certain age group population. The most common diseases are dental caries and periodontal disease and frequently intervention procedures aim, at treating existing problems and restore teeth and related structure to normal function. It is unfortunate that the low priority given to oral health hinders acquisition of data and establishment of effective periodontal care programmes in developing countries but also in some developed countries where the periodontal profile is also less than satisfactory. Despite the fact that in several developed countries there are advanced programmes oriented to periodontal disease treatments, the concern is related to the lack of preventive oriented treatments. According to data available on periodontal status of populations from developed countries, despite the number of dentists and trained specialists, dental health professionals do not presently meet adequately the need for prevention, focusing mainly on curative care. The need for strengthening disease prevention and health promotion programmes in order to improve oral health conditions and particularly periodontal status in the majority of countries around the world is evident. Unfortunately, in many countries, the human, financial and material resources are still insufficient to meet the need for oral health care services and to provide universal access, especially in disadvantaged communities, in both developing and developed countries. Moreover, even though the most widespread illnesses are avoidable, not all population groups are well informed about or able to take advantage of the proper measures for oral health promotion. In addition, in many countries, oral health care needs to be fully integrated into national or community health programmes. Improving oral health is a very challenging objective in developing countries, but also in developed countries, especially with the accelerated aging of the population now underway and intensifying over the coming years.

Kandelman D; Arpin S; Baez RJ; Baehni PC; Petersen PE

2012-10-01

295

APS storage ring vacuum system development  

Energy Technology Data Exchange (ETDEWEB)

The Advanced Photon Source synchrotron radiation facility, under construction at the Argonne National Laboratory, incorporates a large ring for the storage of 7 GeV positrons for the generation of photon beams for the facility's materials research program. The Storage Ring's 1104 m circumference is divided into 40 sectors which contain vacuum, beam transport, control, rf and insertion device systems. The vacuum system will operate at a pressure of 1 nTorr and is fabricated from aluminum. The system includes distributed NeG pumping, photon absorbers with lumped pumping, beam position monitors, vacuum diagnostics and valving. An overview of the vacuum system design and details of selected development program results are presented. 5 refs.

Niemann, R.C.; Benaroya, R.; Choi, M.; Dortwegt, R.J.; Ferry, R.; Goeppner, G.A.; Gonczy, J.D.; Krieger, C.; Howell, J.; Nielsen, R.W.; Roop, B.; Wehrle, R.B.

1991-01-01

296

APS storage ring vacuum system development  

International Nuclear Information System (INIS)

The Advanced Photon Source synchrotron radiation facility, under construction at the Argonne National Laboratory, incorporates a large ring for the storage of 7 GeV positrons for the generation of photon beams for the facility's materials research program. The Storage Ring's 1104 m circumference is divided into 40 sectors which contain vacuum, beam transport, control, rf and insertion device systems. The vacuum system will operate at a pressure of 1 nTorr and is fabricated from aluminum. The system includes distributed NeG pumping, photon absorbers with lumped pumping, beam position monitors, vacuum diagnostics and valving. An overview of the vacuum system design and details of selected development program results are presented. 5 refs.

1991-01-01

297

Development of fully automatic pipe welding system  

International Nuclear Information System (INIS)

We have succeeded in developing a fully automatic TIG welding system; namely CAPTIG that enables unmanned welding operations from the initial layer to the final finishing layer continuously. This welding system is designed for continuous, multilayered welding of thick and large diameter fixed pipes of nuclear power plants and large-size boiler plants where high-quality welding is demanded. In the tests conducted with this welding system, several hours of continuous unmanned welding corroborated that excellent beads are formed, good results are obtained in radiographic inspection and that quality welding is possible most reliably. This system incorporates a microcomputer for fully automatic controls by which it features a seam tracking function, wire feed position automatic control function, a self-checking function for inter-pass temperature, cooling water temperature and wire reserve. (author)

1985-01-01

298

Development of the real time monitor system  

International Nuclear Information System (INIS)

[en] Large-scale simulation technique is studied at the Center for Promotion of Computational Science and Engineering (CCSE) for the computational science research in nuclear fields. Visualization and animation processing technique are studied and developed for efficient understanding of simulation results. The real time monitor system, in which on-going simulation results are transferred from a supercomputer or workstation to a graphic workstation and are visualized and recorded, is described in this report. This system is composed of the graphic workstation and the video equipment connected to the network. The control shell programs are the job-execution shell for simulations on supercomputers, the file-transfer shell for output files for visualization, and the shell for starting visualization tools. Special image processing technique and hardware are not necessary in this system and the standard visualization tool AVS and the UNIX commands are used, so that this system can be implemented and applied in various computer environments. (author)

1996-01-01

299

The development of the KATRIN magnet system  

Energy Technology Data Exchange (ETDEWEB)

The Karlsruhe Tritium Neutrino Experiment KATRIN aims to measure the mass of the electron neutrino with unprecedented accuracy. For this experiment a special magnet system with about 30 LHe bath cooled superconducting magnets grouped in 10 different sections needs to be developed. The magnetic fields required for the electron transport and spectrometer resolution have a level between 3 and 6 T and must be constant in time over months. Further requirements for field homogeneity and tritium compatibility lead to a unique magnet system. A challenging task of this system is to keep the 10 m beam tube of the source magnet at a constant temperature of 30 K with extremely high temperature stability in time and length. This paper presents the general setup and the magnet system data, shows the main requirements, and gives a status about the ongoing work. Furthermore, the cooling concept of the beam tube is discussed.

Noe, M [Forschungszentrum Karlsruhe, Institute for Technical Physics, D-76021 Karlsruhe (Germany); Gehring, R [Forschungszentrum Karlsruhe, Institute for Technical Physics, D-76021 Karlsruhe (Germany); Grohmann, S [Forschungszentrum Karlsruhe, Institute for Technical Physics, D-76021 Karlsruhe (Germany); Neumann, H [Forschungszentrum Karlsruhe, Institute for Technical Physics, D-76021 Karlsruhe (Germany); Kazachenko, O [Forschungszentrum Karlsruhe, Tritium Laboratory, D-76021 Karlsruhe (Germany); Bornschein, B [Forschungszentrum Karlsruhe, Tritium Laboratory, D-76021 Karlsruhe (Germany); Bonn, J [University of Mainz, Physics Institute, D-55099 Mainz (Germany)

2006-06-01

300

Developing 360 degree feedback system for KINS  

International Nuclear Information System (INIS)

[en] This project aims to investigate the feasibility of a 360 degree feedback systems for KINS and to design guiding rules and structures in implementing that systems. Literature survey, environmental analysis and questionnaire survey were made to ensure that 360 degree feedback is the right tool to improve performance in KINS. That review leads to conclusion that more readiness and careful feasibility review are needed before implementation of 360 degree feedback in KINS. Further the project suggests some guiding rules that can be helpful for successful implementation of that system in KINS. Those include : start with development, experiment with one department, tie it to a clear organization's goal, train everyone involve, make sure to try that system in an atmosphere of trust

2003-01-01

 
 
 
 
301

Sensor Development for PEM Fuel Cell Systems  

Energy Technology Data Exchange (ETDEWEB)

This document reports on the work done by Honeywell Sensing and Control to investigate the feasibility of modifying low cost Commercial Sensors for use inside a PEM Fuel Cell environment. Both stationary and automotive systems were considered. The target environment is hotter (100 C) than the typical commercial sensor maximum of 70 C. It is also far more humid (100% RH condensing) than the more typical 95% RH non-condensing at 40 C (4% RH maximum at 100 C). The work focused on four types of sensors, Temperature, Pressure, Air Flow and Relative Humidity. Initial design goals were established using a market research technique called Market Driven Product Definition (MDPD). A series of interviews were conducted with various users and system designers in their facilities. The interviewing team was trained in data taking and analysis per the MDPD process. The final result was a prioritized and weighted list of both requirements and desires for each sensor. Work proceeded on concept development for the 4 types of sensors. At the same time, users were developing the actual fuel cell systems and gaining knowledge and experience in the use of sensors and controls systems. This resulted in changes to requirements and desires that were not anticipated during the MDPD process. The concepts developed met all the predicted requirements. At the completion of concept development for the Pressure Sensor, it was determined that the Fuel Cell developers were happy with off-the-shelf automotive pressure sensors. Thus, there was no incentive to bring a new Fuel Cell Specific Pressure Sensor into production. Work was therefore suspended. After the experience with the Pressure Sensor, the requirements for a Temperature Sensor were reviewed and a similar situation applied. Commercially available temperature sensors were adequate and cost effective and so the program was not continued from the Concept into the Design Phase.

Steve Magee; Richard Gehman

2005-07-12

302

Development of FBR cycle data base system  

International Nuclear Information System (INIS)

In the 'Feasibility Study on Commercialized Fast Reactor Cycle System (F/S)'. scenario evaluations, cost-benefit evaluations and system characteristic evaluations to show significance of the Fast Breeder Reactor (FBR) cycle system introduction concretely are performed in parallel with a design study for FBR plants, reprocessing systems and fabrication systems. In these evaluations, informations such as economic prospects, prospects for supply and demand of resources and a progress of engineering development are used in addition to design information. This report explains a FBR Cycle Database in order to carry out management and search of various design information and the relating information. The prototype system of the database was completed in the 2000 fiscal year, and the problem of the user number restriction of the prototype system has been improved by Web-ization in the 2001 fiscal year. About 7,000 data are stored in this data base (as of the end of March, 2002). The expansion of user etc., and the continuation of input work of various evaluation information will be carried out, in the phase 2 of F/S. (author)

2002-01-01

303

Development of evaluation system for flashing erosion  

International Nuclear Information System (INIS)

[en] Liquid droplet impingement erosion (LDI) is defined as an erosion phenomenon caused by high-speed droplet attack in a wet steam flow, and sometimes observed in a steam piping system of a power plant. In our previous researches, we have developed an LDI evaluation system to evaluate the thinning shape due to LDI on a steam piping within a practically acceptable time. However, present system is not applicable to LDI on a hot-water piping due to flashing phenomena (flashing erosion) because it is difficult to calculate the flashing flow due to sudden phase change and critical flow rate evaluation models needed for LDI evaluation system are not verified in wet steam region. Therefore, in this study, we tried to develop a new flow calculation code for flashing flow and to verify the critical flow rate evaluation models in wet steam region. For flashing flow simulation, based on a present CFD code, pre-conditioning method was adopted to achieve the stable calculation of the water region, and extended look-up table including from low-pressure water to high-pressure dry steam was incorporated. Finally, a new CFD code water-steam flow was developed. Several benchmark tests were conducted and those results show this new code can reproduce the flashing phenomena and is applicable from the very low-speed flow to supersonic flow. Then, HEM model for critical mass flow rate was verified with flashing and wet steam experiments and CFD calculations, and incorporated into LDI evaluation system to extend applicable region of the evaluation system into flashing erosion. (author)

2012-01-01

304

System safety in Stirling engine development  

Energy Technology Data Exchange (ETDEWEB)

The Department of Energy has established a number of broad programs aimed at reducing highway fuel consumption. One of the programs addresses the Stirling engine propulsion system as a possible alternative to the conventional spark-ignition engine. The objective of this program is the development, by 1984, of a Stirling engine system having at least 30% improvement in fuel economy (mpg) over production vehicles powered by conventional spark-ignition engines of the same weight and performance, based on equal BTU content of fuel used. The DOE/NASA Stirling Engine Project Office has required that contractors make safety considerations an integral part of all phases of the Stirling engine development program. As an integral part of each engine design subtask, analyses are being evolved to determine possible modes of failure. The accepted system safety analysis techniques (Fault Tree, FMEA, Hazards Analysis, etc.) are being applied in various degrees of extent at the system, subsystem and component levels. The primary objectives are to identify critical failure areas, to enable removal of susceptibility to such failures or their effects from the system and to minimize risk.

Bankaitis, H.

1981-01-01

305

Reframing Humans in Information Systems Development  

CERN Document Server

Modern society has been transformed by the digital convergence towards a future where technologies embed themselves into the fabric of everyday life. This ongoing merging of social and technological infrastructures provides and necessitates new possibilities to renovate past notions, models and methods of information systems development that accommodates humans as actors within the infrastructure. This shift introduces new possibilities for information systems designers to fulfil more and more everyday functions, and to enhance their value and worth to the user. "Reframing Humans in Infor

Isomaki, Hannakaisa

2011-01-01

306

Development of A Plant Navigation System  

International Nuclear Information System (INIS)

[en] A 'Plant Navigation System (PNS)' is under development to assist nuclear power plant (NPP) operators by automatically displaying the plant situation and plant operational procedures on a CRT screen when abnormalities occur. The operation procedures given in a symptom-oriented manual are expressed in a tree - type flowchart (modified PAD). The optimum operation procedure for an NPP is selected automatically using built-in diagnostic logics based on the current status of the NPP. Concerning the plant situation, the PNS displays important information only on the current status of the NPP. A prototype PNS system is being constructed. (authors)

1998-11-16

307

Systems-based discovery advances drug development.  

Science.gov (United States)

Drug development expenditures continue to escalate, in part reflecting inefficiencies in current drug discovery paradigms. Traditional drug discovery has been dichotomous, focusing either on phenotypic effects of distinct agents in biological systems, without knowledge of respective targets, or on target-based activities of specific molecules in cell-free assays. Driven by advances in biology, engineering, and informatics, new paradigms integrate phenotypic with target-based algorithms into comprehensive, systems-level approaches offering value-added strategies for optimized drug discovery. PMID:23511779

Waldman, S A; Terzic, A

2013-04-01

308

Development of severe accident training support system  

International Nuclear Information System (INIS)

[en] In order for appropriate decision-making during plant operation and management, the professional knowledge, expert's opinion, and previous experiences as well as information for current status are utilized. The operation support systems such as training simulators have been developed to assist these decision-making process, and most of them cover from normal operation to emergency operation because of the very low frequency of severe accident and of uncertaintics included in severe accident phenomena and scenarios. However, the architectures for severe accident management are being established based on severe accident management guidelines in some developed countries. Recentrly, in Korea, as teh severe accident management guideline was developed, the basis for establishing severe accident management architecture is prepared and this leads to the development of tool for systematic education and training for personnel related to severe accident management. The severe accident taining support system thus is developed to assist decision-making during execution of severe accident management guidelines by providing plant status information, prefessional knowledge for phenomena and scenarios, expected behavior for strategy execution, and so on

2001-01-01

309

Development of in-situ monitoring system  

International Nuclear Information System (INIS)

Development of in-situ monitoring system using an optical fiber to measure the real time temperature variation of subsurface water for the evaluation of flow characteristics. We describe the feasibility of developing a fiber-optic temperature sensor using a thermochromic material. A sensor-tip is fabricated by mixing of a thermochromic material powder. The relationships between the temperatures and the output voltages of detectors are determined to measure the temperature of water. It is expected that the fiber-optic temperature monitoring sensor using thermochromic material can be used to measure the real time temperature variation of subsurface water

2010-01-01

310

Quantum phase transitions about parity breaking in matrix product systems  

International Nuclear Information System (INIS)

According to our scheme to construct quantum phase transitions (QPTs) in spin chain systems with matrix product ground states, we first successfully combine matrix product state (MPS) QPTs with spontaneous symmetry breaking. For a concrete model, we take into account a kind of MPS QPTs accompanied by spontaneous parity breaking, though for either side of the critical point the GS is typically unique, and show that the kind of MPS QPTs occur only in the thermodynamic limit and are accompanied by the appearance of singularities, diverging correlation length, vanishing energy gap and the entanglement entropy of a half-infinite chain not only staying finite but also whose first derivative discontinuous. (authors)

2011-01-01

311

EPICS simulation tools for control system development  

Energy Technology Data Exchange (ETDEWEB)

When developing control system software there are many times when the ability to simulate the response of the instrumentation can be very useful. Examples are: (i) when the operator interface is being designed and the users want an idea of what the finished system might took like; (ii) when the interface hardware is not yet available; (iii) when the reaction of the control system to an error condition must be tested, but the actual occurrence of such an error would cause undesirable side effects; (iv) when operators are being trained to use the system; (v) when an improvement or bug fix needs to be tested, but the running system cannot be shut down for long. The Experimental Physics and Industrial Control System (EPICS) provides tools for building simple simulations and interfacing to more complex simulations of accelerator hardware. At the lowest level an individual data channel can be switched to take its input from either a simulated data location or from the actual hardware. At a slightly higher level, sequences can be run on the real-time interface processor so that output to the hardware is intercepted and an appropriate substitute value is provided for the corresponding read-back records. At a still higher level a program can use the Channel Access software bus facility of EPICS to control some global aspect of an accelerator or can interface to an external accelerator simulation instead of the actual accelerator. The goal of testing control system software using simulated hardware is to minimize the changes required in shifting between the simulated system and the real system. The degree of success of the EPICS tools in meeting the minimum change goal will be addressed with suggestions for improvements. The implementation of simulated responses using EPICS tools will be discussed and examples of experience using the EPICS tools to create and interface to simulations will be given.

Wright, R.M.; Kerstiens, D.M.; Vaughn, G.D.; Weiss, R.E.

1994-09-01

312

Remote viewing system development in BNFL  

Energy Technology Data Exchange (ETDEWEB)

The application of imaging systems to BNFL`s plants is primarily provided by the Company`s Engineering Group. Many systems have been developed for active service and several new developments are currently in an advanced stage of implementation. BNFL has acquired extensive experience of remote viewing from a series of projects undertaken for the Sellafield site in West Cumbria. Applications vary in size and complexity, from simple identification of bar-codes to more complex schemes for remotely storing UO{sub 3} drums. Some are high speed and highly repetitive, whereas others are low speed but require high precision. In this paper the authors shall outline a selection of current applications. (Author).

Case, D.R. [BNFL Engineering Ltd., Salford (United Kingdom); Garlick, D.R.; Crawford, G.; Montgomerie, J. [British Nuclear Fuels plc, Risley (United Kingdom)

1996-12-31

313

Coal-log pipeline system development  

Energy Technology Data Exchange (ETDEWEB)

Project tasks include: (1) Perform the necessary testing and development to demonstrate that the amount of binder in coal logs can be reduced to 8% or lower to produce logs with adequate strength to eliminate breakage during pipeline transportation, under conditions experienced in long distance pipeline systems. Prior to conducting any testing and demonstration, grantee shall perform an information search and make full determination of all previous attempts to extrude or briquette coal, upon which the testing and demonstration shall be based. (2) Perform the necessary development to demonstrate a small model of the most promising injection system for coal-logs, and tests the logs produced. (3) Conduct economic analysis of coal-log pipeline, based upon the work to date. Refine and complete the economic model. (VC)

Liu, H.

1991-12-01

314

Development of technical information processing system (VII)  

International Nuclear Information System (INIS)

The goal of this project is to establish integrated environment focused on enhanced information services to researchers through the providing of acquisition information, key phrase retrieval function, journal content information linked with various subsystems already developed. The results of the project are as follows. 1. It is possible to serve information on unreceivable materials among required materials throughout the system. 2. Retrieval efficiency is increased by the adding of key phrase retrieval function. 3. Rapidity of information service is enhanced by the providing of journal contents of each issue received and work performance of contents service is become higher. 4. It is possible to acquire, store, serve technical information needed in R and D synthetically and systematically throughout the development of total system linked with various subsystems required to technical information management and service. 21 refs. (Author).

1995-01-01

315

Remote maintenance system development for ITER blankets  

International Nuclear Information System (INIS)

In ITER, the in-vessel components such as blanket are to be maintained or replaced remotely since they will be activated by 14 MeV neutrons. For this, the remote handling equipment for blanket maintenance is required to handle a heavy payload of about 4 tonne within a positioning accuracy of 2 mm. According to the ITER R and D program, a rail-mounted vehicle manipulator system was developed and remote replacement of blanket module has been successfully demonstrated using the fabricated full-scale vehicle manipulator system. In addition, the bore tools moving inside the blanket cooling pipes were also developed, and remote welding, cutting and inspection operations for the blanket maintenance have been verified. (author)

1999-01-01

316

Remote maintenance system development for ITER blankets  

Energy Technology Data Exchange (ETDEWEB)

In ITER, the in-vessel components such as blanket are to be maintained or replaced remotely since they will be activated by 14 MeV neutrons. For this, the remote handling equipment for blanket maintenance is required to handle a heavy payload of about 4 tonne within a positioning accuracy of 2 mm. According to the ITER R and D program, a rail-mounted vehicle manipulator system was developed and remote replacement of blanket module has been successfully demonstrated using the fabricated full-scale vehicle manipulator system. In addition, the bore tools moving inside the blanket cooling pipes were also developed, and remote welding, cutting and inspection operations for the blanket maintenance have been verified. (author)

Tada, Eisuke; Kakudate, Satoshi; Oka, Kiyoshi; Nakahira, Masataka; Obara, Kenjirou; Shibanuma, Kiyoshi [Reactor Structure Lab., Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan)

1999-07-01

317

Legacy Information System Development: Problems and Issues  

Directory of Open Access Journals (Sweden)

Full Text Available The Information Communication Technology has improved the quality of services being provided by organizations beyond proportions. Another most distinguishing characteristic of ICT is the storage, retrieval, processing as well as the communication of Data. However development of Information System is always associated with many problems and issues. In fact resistance to change is a universally acknowledged fact but since the influence of ICT is felt at all levels therefore automation mostly meets multifold problems. It is because of this fact that despite distinct superiority of ICT still it is implemented in phased manner. Similarly the available technology also limits the working of the Information System. Other issues related with the development of the information are the developmental, operational besides security.

Muheet Ahmed Butt

2012-01-01

318

Development of nuclear plant Operation Management System  

Energy Technology Data Exchange (ETDEWEB)

Recently it has become more important to detect a change in operational characteristics and to take appropriate corrective actions before it deteriorates to an incident in nuclear power plants. Therefore, aiming at earlier detection of a tendency change, swifter corrective actions and more effective application of operational data, we have developed Operation Management System which automatically acquires, accumulates and observes operational data of Hamaoka Nuclear Power Station through cycles. (author)

Koide, I.; Okada, T.; Ishida, K. [Chubu Electric Power Co. Inc., Nagoya (Japan)

1998-09-01

319

Development of nuclear plant Operation Management System  

International Nuclear Information System (INIS)

[en] Recently it has become more important to detect a change in operational characteristics and to take appropriate corrective actions before it deteriorates to an incident in nuclear power plants. Therefore, aiming at earlier detection of a tendency change, swifter corrective actions and more effective application of operational data, we have developed Operation Management System which automatically acquires, accumulates and observes operational data of Hamaoka Nuclear Power Station through cycles. (author)

1998-01-01

320

Development of cask and transportation system  

International Nuclear Information System (INIS)

Transportation of spent fuels to the AFR interim storage facility and disposal repository are necessary in Korea. Therefore, an emphasis has been concentrated to develop the design and fabrication technology of commercial casks. A conceptual design of the temperature and deformation measuring systems in the cask, which will be used for mock-up tests has been performed. Preliminary design data of the cask for 7 spent PWR fuels have been obtained in the course of study. (author).

1990-01-01

 
 
 
 
321

Development of a Parallel Redundant STATCOM System  

Science.gov (United States)

This paper presents a new concept of parallel redundant STATCOM system. This system consists of a number of medium capacity STATCOM units connected in parallel, which can achieve a high operational reliability and functional flexibility. The proposed STATCOM system has such redundant operation characteristics that the remaining STATCOM units can maintain their operation even though some of the STATCOM units are out of service. And also, it has flexible convertibility so that it can be converted to a BTB or a UPFC system easily, according to the diversified change of needs in power systems. In order to realize this concept, the authors developed several important key technologies for the STATCOM, such as the novel PWM scheme that enables effective cancellation of lower order harmonics, GCT inverter technologies with small loss consumption, and the coordination control scheme with capacitor banks to ensure effective dynamic performance with minimum loss consumption. The proposed STATCOM system was put into practical applications, exhibiting excellent performance characteristics at each site.

Takeda, Masatoshi; Yasuda, Satoshi; Tamai, Shinzo; Morishima, Naoki

322

SNS EXTRACTION FAST KICKER SYSTEM DEVELOPMENT.  

Energy Technology Data Exchange (ETDEWEB)

The SNS Extraction Fast Kicker System is a very high power, high repetition rate pulsed power system. It was design and developed at Brookhaven National Laboratory. This system will consist of fourteen identical high voltage, high current modulators, and their auxiliary control and charging systems. The modulators will drive fourteen extraction magnet sections located inside of the SNS accumulator ring. The required kicker field rise time is 200 ns, a pulse flattop of 700 ns, a pulse repetition rate of 60 pulse-per-second. A 2500 Ampere per modulator output is required to reach the extraction kicker magnetic field strength. This design features a Blumlein Pulse-Forming-Network based topology, a low beam impedance termination, a fast current switching thyratron, and low inductance capacitor banks. It has a maximum charging voltage of 50kV, an open circuit output of 100kV, and a designed maximum pulsed current output of 4kA per modulator. The overall system output will be multiple GVA with 60 Pulse-per-second repetition rate. A prototype modulator has been successfully built and tested well above the SNS requirement. The modulator system production is in progress.

ZHANG,W.; SANDBERG,J.; LAMBIASE,R.; LEE,Y.Y.; LOCKEY,R.; MI,J.; NEHRING,T.; PAI,C.; TSOUPAS,N.; TUOZZOLO,J.; WARBURTON,D.; WEI,J.; RUST,K.; CUTLER,R.

2003-06-15

323

Thermal performance advisor expert system development  

International Nuclear Information System (INIS)

[en] In recent years the electric industry has developed an increased interest in improving efficiency of nuclear power plants. EPRI has embarked upon a research project RP2407, Nuclear Plant Performance Improvements which is designed to address needs in this area. One product of this project has been the Thermal Performance Diagnostic Manual for Nuclear Power Plants (NP-4990P). The purpose of this manual is to provide engineering personnel at nuclear power plants with a consistent way in which to identify thermal performance problems. General Physics is also involved in the development of another computer system called Fossil Thermal Performance Advisor (FTPA) which helps operators improve performance for fossil power plants. FTPA is a joint venture between General Physics and New York State Electric and Gas Company. This paper describes both of these computer systems and uses the FTPA as an interesting comparison that illustrates the considerations required for the development of a computer system that effectively addresses the needs of the users

1991-01-01

324

Health care system reform in developing countries  

Directory of Open Access Journals (Sweden)

Full Text Available This article proposes a critical but non-systematic review of recent health care system reforms in developing countries. The literature reports mixed results as to whether reforms improve the financial protection of the poor or not. We discuss the reasons for these differences by comparing three representative countries: Mexico, Vietnam, and China. First, the design of the health care system reform, as well as the summary of its evaluation, is briefly described for each country. Then, the discussion is developed along two lines: policy design and evaluation methodology. The review suggests that i) background differences, such as social development, poverty level, and population health should be considered when taking other countries as a model; ii) although demand-side reforms can be improved, more attention should be paid to supply-side reforms; and iii) the findings of empirical evaluation might be biased due to the evaluation design, the choice of outcome, data quality, and evaluation methodology, which should be borne in mind when designing health care system reforms.

Wei Han

2012-01-01

325

Development of decommissioning engineering support system for fugen. Development of support system during actual dismantlement works  

International Nuclear Information System (INIS)

The Advanced Thermal Reactor, Fugen Nuclear Power Station was permanently shut down in March 2003, and is now preparing for decommissioning. We have been developing Decommissioning Engineering Support System (DEXUS) aimed at planning optimal dismantlement process and carrying out dismantlement work safely and precisely. DEXUS consists of 'decommissioning planning support system' and 'dismantling support system'. The dismantling support system is developed aiming at using during actual dismantling work. It consists of three subsystems such as 'Worksite Visualization System', 'Dismantling Data Collection System' and 'Generated Waste Management System'. 'Worksite Visualization System' is a support system designed to provide the necessary information to workers during actual dismantlement works. And this system adopts AR (Augmented Reality) technology, overlapping calculation information into real world. 'Dismantling Data Collection System' is to collect necessary data for improving accuracy of decommissioning planning by evaluating work content and worker equipage, work time for dismantlement works. 'Generated Waste Management system' is a system recording necessary information by attaching the barcode to dismantled wastes or the containers. We can get the information of generated waste by recording generation place, generated time, treatment method and the contents. These subsystems enable to carry out reasonable and safe decommissioning of Fugen. In addition, we expect that those systems will be used for decommissioning of other nuclear facilities in the future. (authors)

2005-01-01

326

Development of an automated handwriting analysis system  

Directory of Open Access Journals (Sweden)

Full Text Available In the present study a method has been proposed for the behavioral prediction of a person through automated handwriting analysis. The present work identifies the psychological traits in the writing namely size, slant and pressure, baseline, number of breaks, margins, speed of writing and spacing between the words. The handwriting is analyzed through Image Processing in MATLAB. The behavioral pattern of the person is predicted from the above traits of the handwriting. The developed system identifies handwriting closely which may not be possible for a graphologist. It is real time and involves less image preprocessing. The proposed system is calibrated with manual analysis. The results obtained through the system are in good agreement to more than 80 percent of the cases with ideal manual analysis.

Vikram Kamath; Nikhil Ramaswamy; P. Navin Karanth; Vijay Desai; S. M. Kulkarni

2011-01-01

327

Development of the environmental neutron detection system  

CERN Multimedia

Environmental neutron detection system was proposed and developed. The main goal of this system was set to detect fast and thermal neutrons with the identical detectors setup without degraders. This system consists of a sup 1 sup 0 B doped liquid scintillator for n detection and CsI scintillators for simultaneous gamma emission from sup 1 sup 0 B doped in the liquid scintillator after the n capture reaction. The first setup was optimized for the thermal n detection, while the second setup was for the fast n detection. It was shown that the thermal n flux was obtained in the first setup by using the method of the gamma coincidence method with the help of the Monte Carlo calculation. The second setup was designed to improve the detection efficiency for the fast n, and was shown qualitatively that both the pulse shape discrimination and the coincidence methods are efficient. There will be more improvements, particularly for the quantitative discussion.

Kume, K

2002-01-01

328

Optimal Control Development System for Electrical Drives  

Directory of Open Access Journals (Sweden)

Full Text Available In this paper the optimal electrical drive development system is presented. It consists of both electrical drive types: DC and AC. In order to implement the optimal control for AC drive system an Altivar 71 inverter, a Frato magnetic particle brake (as load), three-phase induction machine, and dSpace 1104 controller have been used. Theon-line solution of the matrix Riccati differential equation (MRDE) is computed by dSpace 1104 controller, based on the corresponding feedback signals, generating the optimal speed reference for the AC drive system. The optimal speed reference is tracked by Altivar 71 inverter, conducting to energy reduction in AC drive. The classical control (consisting of rotor field oriented control with PI controllers) and the optimal one have been implemented by designing an adequate ControlDesk interface. The three-phase induction machine (IM) is controlled at constant flux. Therefore, the linear dynamic mathematical model of the IM has been obtained. The optimal control law providestransient regimes with minimal energy consumption. The obtained solution byintegration of the MRDE is orientated towards the numerical implementation-by using azero order hold. The development system is very useful for researchers, doctoralstudents or experts training in electrical drive. The experimental results are shown.

Marian GAICEANU; Emil ROSU; Romeo PADURARU; Cristinel DACHE

2008-01-01

329

Development of an intellectual maintenance management system. Development of trouble detection and troubleshooting evaluation system  

Energy Technology Data Exchange (ETDEWEB)

Many research activities are conducted to enhance cost performance and safety of nuclear power plants operation and maintenance. Concept of autonomous operating system to equal the role of operators and of maintenance personnel with artificial intelligence and autonomous robots has been developed. An intellectual maintenance management system has been developed to be equipped with decision making functions of maintenance personnel. The intellectual maintenance management system is in charge of maintenance function of an autonomous plant, which consists of plant-wide monitoring, evaluation of component integrity, and scheduling of maintenance activities. In other words, this system should be equipped with preventive maintenance and corrective maintenance functions those are currently loaded on personnel. In this report, we discussed condition monitoring maintenance in the preventive maintenance. We also reported a sensor validation system development for machinery condition monitoring and diagnosis. We adopted distributed and cooperative system construction technique, which is expected recently in applications to large-scale plants. This system has inter-agent communication function for signal transmission and reception among distributed physics models of machineries. The system has been constructed for water/steam system of the LMFBR power plant. The system has been validated to be capable of cooperative sensor validation by the distributed set of agents, with quantitative indication of sensor deviation based on a newly developed fuzzy algorithm with inter-agent cooperation. The derived reference parameter value from the inter-agent evaluations also stands for the alternative measurement to the malfunctioned sensor. (author)

Suda, Kazunori; Yoshikawa, Shinji; Tani, Satoshi [Power Reactor and Nuclear Fuel Development Corp., Oarai, Ibaraki (Japan). Oarai Engineering Center

1998-03-01

330

Systems approach to tuberculosis vaccine development.  

UK PubMed Central (United Kingdom)

Tuberculosis is both highly prevalent across the world and eludes our attempts to control it. The current bacillus Calmette-Guérin vaccine has unreliable protection against adult pulmonary tuberculosis. As a result, tuberculosis vaccine development has been an ongoing area of research for several decades. Only recently have research efforts resulted in the development of several vaccine candidates that are further along in clinical trials. The majority of the barriers surrounding tuberculosis vaccine development are related to the lack of defined biomarkers for tuberculosis protective immunity and the lack of understanding of the complex interactions between the host and pathogen in the human immune system. As a result, testing various antigens discovered through molecular biology techniques have been only with surrogates of protection and do not accurately predict protective immunity. This review will address new discoveries in latency antigens and new next-generation candidate vaccines that promise the possibility of sterile eradication. Also discussed are the potentially important roles of systems biology and vaccinomics in shortening development of an efficacious tuberculosis vaccine through utilization of high-throughput technology, computer modelling and integrative approaches.

Wang CC; Zhu B; Fan X; Gicquel B; Zhang Y

2013-04-01

331

Development of Safety Assessment Information System (SAIS)  

Energy Technology Data Exchange (ETDEWEB)

Many reports and documents about nuclear power plant safety analysis like a Periodic Safe Review (PSR), Periodic Safety Analysis (PSA) and Severe Accident Management Guideline (SAMG) come to be drawn up from KHNP. Since these are not arranged easy to look up, the systematic arrangement of data was necessary. The solution against hereupon is to store database, and it was developed with the name, SAIS, by FNC Tech. Co. together with NETEC KHNP. In this web program it is easy to manage (registration, search and statistics) data. And the authorized user can approach this system. This was developed, and was verified under the development environment of; - Web Server : Apache 2.2.5 - Program Language : PHP 5.2 - DBMS : Oracle 10g.

Park, Byung Shik; Lee, Kyung Jin; Lee, Byung Chul [FNC Tech. Co. Ltd. SNU, Seoul (Korea, Republic of); Song, Tae Young; Lee, Chang Ho [KHNP, Daejeon (Korea, Republic of)

2007-10-15

332

Developing an information systems strategy for nursing.  

Science.gov (United States)

With the rapidly changing health care environment and information technology advances, organizations need to engage in strategic, planned change in order to allocate limited resources, achieve the organization's goals, and fulfill its mission [1]. One of the most important aspects of the organization's planned strategies for change concerns the information systems. The involvement of the nursing department in this process is critical. This poster presentation will communicate how nurses can develop an information systems strategic plan that will enable them to play an active role as contributors and vital participants in the strategic and business planning processes for information systems. This information systems strategy for nursing will: a) provide direction and purpose, b) guide nursing in identifying the kinds of information technology needed, c) assist in timely implementation of a system that supports nursing, and d) identify desired outcomes and benefits of an information system. The nursing information systems plan must be built on, and support, the organization's mission and business plan and integrate into the over-all information systems plans [2]. Components of the nursing strategic plan include the nursing mission statement and vision, an assessment of the current environment to identify supporting technology needed to achieve the nursing vision, expectations/anticipated outcomes, environmental considerations, and special staffing/expertise considerations. The nursing vision and mission statement is an articulation of the overall direction and purpose of the nursing organization. An assessment of the nursing organization, problem areas, opportunities for growth, the physical environment, existing systems, communications requirements, and resources is carried out to help identify areas where new technologies and automated methods of managing information could be applied. Special staffing and expertise not currently available in the organization, but necessary to the successful implementation of the plan, should be identified, and plans for filling those needs should be included in the planning and prioritization process. Based on the mission and assessment findings, goals or anticipated outcomes are developed. These goals must be realistic, financially feasible, and logistically achievable; they should also provide direction for action and decision-making [3]. Measurable objectives and detailed action plans can then be developed from these goals when implementation of this aspect of the strategic plan is begun. It is especially important, even at a strategic planning level, to consider change management techniques, including specific steps to involve individuals who will be affected by the change and to ensure open communication throughout the process. Efforts to collaborate with all affected departments and to offer input and educational opportunities to the various members of the health care team should be included in the strategic plan. A business plan describing the mission, goals, and objectives for a specific system implementation is the final step in the strategic planning process. The business plan includes expected outcomes and cost justification and may be done in cooperation with other departments (in the organization) that will be involved with this system. The business plan is used to communicate the information system's needs to the administration and governing board of the organization. With a good information systems strategy, nursing will be prepared to make more timely and better informed decisions related to applying information technology within the nursing department. The end results of this planning should be evident in the improved utilization of information technology to support the nursing vision and mission. PMID:8591465

Callanan, K M; Hughes, S J

1995-01-01

333

Developing an information systems strategy for nursing.  

UK PubMed Central (United Kingdom)

With the rapidly changing health care environment and information technology advances, organizations need to engage in strategic, planned change in order to allocate limited resources, achieve the organization's goals, and fulfill its mission [1]. One of the most important aspects of the organization's planned strategies for change concerns the information systems. The involvement of the nursing department in this process is critical. This poster presentation will communicate how nurses can develop an information systems strategic plan that will enable them to play an active role as contributors and vital participants in the strategic and business planning processes for information systems. This information systems strategy for nursing will: a) provide direction and purpose, b) guide nursing in identifying the kinds of information technology needed, c) assist in timely implementation of a system that supports nursing, and d) identify desired outcomes and benefits of an information system. The nursing information systems plan must be built on, and support, the organization's mission and business plan and integrate into the over-all information systems plans [2]. Components of the nursing strategic plan include the nursing mission statement and vision, an assessment of the current environment to identify supporting technology needed to achieve the nursing vision, expectations/anticipated outcomes, environmental considerations, and special staffing/expertise considerations. The nursing vision and mission statement is an articulation of the overall direction and purpose of the nursing organization. An assessment of the nursing organization, problem areas, opportunities for growth, the physical environment, existing systems, communications requirements, and resources is carried out to help identify areas where new technologies and automated methods of managing information could be applied. Special staffing and expertise not currently available in the organization, but necessary to the successful implementation of the plan, should be identified, and plans for filling those needs should be included in the planning and prioritization process. Based on the mission and assessment findings, goals or anticipated outcomes are developed. These goals must be realistic, financially feasible, and logistically achievable; they should also provide direction for action and decision-making [3]. Measurable objectives and detailed action plans can then be developed from these goals when implementation of this aspect of the strategic plan is begun. It is especially important, even at a strategic planning level, to consider change management techniques, including specific steps to involve individuals who will be affected by the change and to ensure open communication throughout the process. Efforts to collaborate with all affected departments and to offer input and educational opportunities to the various members of the health care team should be included in the strategic plan. A business plan describing the mission, goals, and objectives for a specific system implementation is the final step in the strategic planning process. The business plan includes expected outcomes and cost justification and may be done in cooperation with other departments (in the organization) that will be involved with this system. The business plan is used to communicate the information system's needs to the administration and governing board of the organization. With a good information systems strategy, nursing will be prepared to make more timely and better informed decisions related to applying information technology within the nursing department. The end results of this planning should be evident in the improved utilization of information technology to support the nursing vision and mission.

Callanan KM; Hughes SJ

1995-01-01

334

Development of the Medium Energy Linac Systems  

Energy Technology Data Exchange (ETDEWEB)

The main purposes of the proton engineering frontier project is developing a proton linac which accelerates 20 mA proton beams up to 100 MeV and supplying 20 MeV and 100 MeV proton beams to the user groups. The project 'Development of the medium energy linac systems' is aiming to design the 100 MeV proton linac, to construct an accelerating cavity, to design a MEBT system, and to develop a energy measurement system. The 100 MeV linac consists of 20 DTL tanks which are operated by five additional klystrons. The focusing lattice is FFDD as the 20 MeV DTL. However the hollow conductors are used for coils of the quadrupole magnets. The shape of the drift tubes in the new tanks is changed to compensate the reduction of the accelerating efficiency in the high energy region. For example, the face angle of drift tubes begins at 40 degrees. The bore radius is selected as 10 mm in order to eliminate beam loss in the beam line. We can obtain the 100 MeV proton beams by using these accelerating structure. We have designed some of the tanks in detail. It covers the modification of the structure by including the stem, post-coupler, and sulg-tuner effects, the error analysis, the thermal and structure analysis, the drift tube design, the magnet design, the various ports design, the support structure design, the end-plate design, etc. Now the first DTL tank is constructed by a local company. An beam extraction system is essential after 20 MeV DTL in order to supply 20 MeV proton beams. Since there are no focusing elements in the structure, the beam should be spread out. The MEBT which consists of two 3-cell DTL tanks is designed to control the beam size in the beam extraction system by magnets in the first tank and to transversely match the beam into the next DTL by magnets in the the second tank. The longitudinal matching is done by the RF in both tanks. We have also developed an energy measurement system using the time of flight method.

Jang, Ji Ho; Kwon, H. J.; Kim, Y. H. (and others)

2005-07-15

335

Implementing Life Cycle Assessment in systems development.  

DEFF Research Database (Denmark)

Today's industry is being forced to consider the environmental performance of its products concurrently with traditional requirements such as quality, price or functional performance. The Life Cycle Assessment (LCA) technique has been identified as a powerful tool to calculate environmental impacts derived from products and system, and calculate resource consumptions. However, the complexity of LCA poses restrictions to its use in current product and system development given the need for a reduction in product development cycle time which is needed to meet the increasing competitive pressures and the rapid changes in markets for many products. The overall aim of the paper is to provide an understanding of the environmental issues involved in the early stages of product development and the capacity of life cycle assessment techniques to address these issues. The paper aims to outline the problems for the designer in evaluating the environmental benignity of the product from the outset and to provide the designer with a framework for decision support based on the performance evaluation at different stages of the design process. The overall aim of this paper is to produce an in-depth understanding of the barriers to implementation of LCA by developers of products, and of the opportunities for introducing environmental criteria in the design process through meeting the information requirements of the designer on the different life cycle stages, producing an in-depth understanding of the attitudes of practitioners among product developers to the subject area, and an understanding of possible future directions for product development. An Environmentally Conscious Design method is introduced and trade-offs are presented between design degrees of freedom and environmental solutions. It also discusses a number of possibilities which can be introduced in the design stage compared to the other life cycle stages of the product system. The paper collects experiences and ideas around the state-of-the-art in eco-design, from literature and personal experience and further provides eco-design life cycle assessment strategies. The paper reviews the current environmental evaluation practices with respect to product life cycles. As a number of deficiencies in LCA are identified, strategies are presented to provide a solution to many of the deficiencies. The result of the paper is a definition of the requirements for performance measurement techniques and a performance measurement environment necessary to support life cycle evaluation throughout the evaluation of early stages of a product system.

Bhander, Gurbakhash Singh; Hauschild, Michael Zwicky

2003-01-01

336

Horse-like walking, trotting, and galloping derived from kinematic Motion Primitives (kMPs) and their application to walk/trot transitions in a compliant quadruped robot.  

Science.gov (United States)

This manuscript proposes a method to directly transfer the features of horse walking, trotting, and galloping to a quadruped robot, with the aim of creating a much more natural (horse-like) locomotion profile. A principal component analysis on horse joint trajectories shows that walk, trot, and gallop can be described by a set of four kinematic Motion Primitives (kMPs). These kMPs are used to generate valid, stable gaits that are tested on a compliant quadruped robot. Tests on the effects of gait frequency scaling as follows: results indicate a speed optimal walking frequency around 3.4 Hz, and an optimal trotting frequency around 4 Hz. Following, a criterion to synthesize gait transitions is proposed, and the walk/trot transitions are successfully tested on the robot. The performance of the robot when the transitions are scaled in frequency is evaluated by means of roll and pitch angle phase plots. PMID:23463501

Moro, Federico L; Spröwitz, Alexander; Tuleu, Alexandre; Vespignani, Massimo; Tsagarakis, Nikos G; Ijspeert, Auke J; Caldwell, Darwin G

2013-03-06

337

Development of cost-benefit analysis system  

Energy Technology Data Exchange (ETDEWEB)

In order to promote the FDR development, it is necessary to see various benefits brought by introduction of FBR from multiple perspectives and have a good grasp of such benefits quantitatively and an adequate R and D investment scale which corresponds with them. In this study, the structured prototype in the previous study was improved to be able to perform cost-benefit analysis. An example of improvement made in the system is addition of subroutine used for comparison between new energy and benefits brought by introduction of FBR with special emphasis on addition of logic for analyzing externality about the new energy. Other improvement examples are modification of the Conventional Year Expense Ratio method of power generation cost to Average Durable Year Cost method, addition of database function and turning input data into database, and reviewing idea on cost by the type of waste material and price of uranium. The cost-benefit analysis system was also restructured utilizing Microsoft ACCESS so that it should have a data base function. As the result of the improvement mentioned above, we expect that the improved cost-benefit analysis system will have higher generality than the system before; therefore, great deal of benefits brought by application of the system in the future is expected. (author)

Shiba, Tsuyoshi; Mishima, Tetsuya; Yuyama, Tomonori; Suzuki, Atsushi [Mitsubishi Research Institute Inc., Tokyo (Japan)

2001-01-01

338

Development of superconducting ship propulsion system  

International Nuclear Information System (INIS)

When we plan displacement-type monohull high speed vessels, it is difficult to get the hull form with the wave-making resistance minimum, because the stern shape is restricted by arrangement of propulsive machines and shafts. A small-sized and light-weight propulsive machines will reduce the limit to full form design. Superconducting technology will have capability of realizing the small-sized and light-weight propulsion motor. The superconducting electric propulsion system which is composed of superconducting propulsion motors and generators, seems to be an ideal propulsion system for future vehicles. We have constructed a 480 kW superconducting DC homopolar laboratory test motor for developing this propulsion system. The characteristic of this motor is that it has a superconducting field winding and a segmented armature drum. The superconducting field winding which operates in the persistent current mode, is cooled by a condensation heat exchanger and helium refigerating system built into the cryostat of the superconducting field winding. The operating parameters of this motor agreed well with the design parameters. Using the design concepts of this motor, we have conceptually designed a 150,000-200,000 PS superconducting electric propulsive system for a displacement-type monohull high speed ship. (author)

1991-01-01

339

Development of JRR-4 operation support system  

International Nuclear Information System (INIS)

The Japan Research Reactor No.4 (JRR-4) is a light water moderated and cooled, graphite reflected, pool-type reactor with the thermal output of 3500 kW. In February 1996, a work on core modification from high-enriched fuels to low-enriched ones was started and the work on modification was completed in May 1998. As a part of the work, Operation Support System (OSS) was adopted for the purpose of reducing load of operator, preventing operator's error and supplying operation data to users. In this paper, JRR-4 Operation Support System's configuration, characteristics and development process are described. OSS consists mainly of a workstation (WS), ?XL and Personal Computer (PC). WS is used for collection of operation data. ?XL is used for cooling system control and PC is used for operators' support. All of the program applications used in WS, ?XL and PC are designed to make sure of high flexibility for the demands on modification from operators and new operation modes. The result of adopting this system, the consolidation monitoring, automation of part of reactor operation and data management were realized. In addition, the cooling control system was compacted. (author)

1999-01-01

340

DEVELOPMENT OF WIRELESS PATIENT DATA MANAGEMENT SYSTEM  

Directory of Open Access Journals (Sweden)

Full Text Available Wireless networking technology enables two or more computers to communicate and relay data using standard network protocols, without the hassle of network wiring and cabling. Wireless networking hardware requires the use of underlying technology that deals with radio frequencies as and data transmission. Hospitals, medical centers, and rural clinics will benefit from the implementation of wireless technology particularly cell phones and PDA (Personal Digital Assistant) to healthcare field. Healthcare providers especially physicians and nurses will experience a more pleasant working environment, reduced workload and saves time and energy. More importantly they will be able to provide the point-of-care to patients and ensure that patients get the best of healthcare services. This project develops a wireless patient data management system using ASP, and this data management system should be able to be accessed from any devices that have wireless internet connection, including cell phones and PDAs. To simulate the results from the programming, Openwave Simulator is used to visualize the real outcome if a cell phone integrated with GPRS (General Packet Radio Services) or WAP (Wireless Application Protocol) technology had been implemented instead. Currently the users of this system view patient list, add patient or information about the patient profile, and prescribe medication to the patient. Unauthorized personnel will not be able to enter this wireless patient data management system. The authentication procedure is very important in protecting patient’s information, and from the malicious attacks of unauthorized intruders to the patient data management system. The feasibility of using a mobile phone to retrieve patient data is still in the infancy stage, worldwide. With the rapid development of wireless technology, wireless technologies will soon appear in Malaysian healthcare industry.

HIDAYATUL AINI BINTI ZAKARIA; NAHRIZUL ADIB BIN KADRI

2007-01-01

 
 
 
 
341

Development and application of earth system models.  

UK PubMed Central (United Kingdom)

The global environment is a complex and dynamic system. Earth system modeling is needed to help understand changes in interacting subsystems, elucidate the influence of human activities, and explore possible future changes. Integrated assessment of environment and human development is arguably the most difficult and most important "systems" problem faced. To illustrate this approach, we present results from the integrated global system model (IGSM), which consists of coupled submodels addressing economic development, atmospheric chemistry, climate dynamics, and ecosystem processes. An uncertainty analysis implies that without mitigation policies, the global average surface temperature may rise between 3.5 °C and 7.4 °C from 1981-2000 to 2091-2100 (90% confidence limits). Polar temperatures, absent policy, are projected to rise from about 6.4 °C to 14 °C (90% confidence limits). Similar analysis of four increasingly stringent climate mitigation policy cases involving stabilization of greenhouse gases at various levels indicates that the greatest effect of these policies is to lower the probability of extreme changes. The IGSM is also used to elucidate potential unintended environmental consequences of renewable energy at large scales. There are significant reasons for attention to climate adaptation in addition to climate mitigation that earth system models can help inform. These models can also be applied to evaluate whether "climate engineering" is a viable option or a dangerous diversion. We must prepare young people to address this issue: The problem of preserving a habitable planet will engage present and future generations. Scientists must improve communication if research is to inform the public and policy makers better.

Prinn RG

2013-02-01

342

Development of radiation detection and measurement systems  

International Nuclear Information System (INIS)

[en] This report contains descriptions on the following six items. The first item is the result of a study on CsI(TI) crystals with their light emitting characteristics and the result of a study on plastic scintillators. The second item is the result of a study on advanced radiation detectors and includes experiments for the effect of using a Compton suppressor with an HPGe detector. For the third item, we describe the results of a design work done using EGS4 for a thickness gauge, a density gauge, and a level gauge. The fourth item contains descriptions on the prototype circuit systems developed for a level gauge, a thickness gauge, and for a survey meter. The fifth part contains the computed tomography algorithm and a prototype scanning system developed for a CT system. As the sixth and the last item, we describe the prototype high precision heat source and the prototype heat-voltage converter which we have designed and fabricated

2000-01-01

343

New developments of the GANIL Control System  

Energy Technology Data Exchange (ETDEWEB)

Since the first ion beam, the GANIL accelerator has been driven by a Control System built around a minicomputer MITRA 125 and a distributed intelligence consisting of Programmable Controllers and INTEL 8080-equipped autonomous CAMAC Controllers. CAMAC is the digital transmission standard adopted to interface the processors to the GANIL facilities. In order to cope with the growing needs of the accelerator operation, many developments of the Control System have been carried out during the last years or are underway. After a brief description of the GANIL Control System, this paper describes the major improvements undertaken in four main directions: a) Upgrading the Control Computer. The minicomputer MITRA 125 will be replaced by a faster one equipped with much larger memories and disk capabilities. b) Introducing more powerful local intelligence. An autonomous CAMAC Controller called DIVA 68C using the 68000 microprocessor has been developed. Also, the 68000 will be used in a general purpose CAMAC module, the first application of which is to replace the existing data link modules. c) Improving the human-machine interface with the use of color graphic terminals. d) Meeting the requirements for the coming second injector. For this purpose, a fully equipped auxiliary console is being installed near the main console for operation by summer 1985.

Lecorche, E.

1986-06-01

344

Development of electricity distribution systems in developing countries  

Energy Technology Data Exchange (ETDEWEB)

This research has been implemented in cooperation with the Ethiopian Electric Light and Power Authority (EELPA). Its aim was to produce a means of optimizing the distribution systems in Ethiopia, but the results are also partly applicable in other countries where similar conditions prevail. The main target areas were the selection of a medium voltage, system configurations and neutral earthing methods. The medium voltage study was based on the theory and computer programs introduced in the previous stage of the project implemented at Tampere University of Technology. The practical studies were performed under Ethiopian conditions, and the results indicated that there is no reason to convert the present 15 kV medium voltage level to any other voltage level at the moment. Thus the option for gradual converting from 15 kV to 20 kV, which proved to be the best medium voltage level for future requirements, could be reserved for long-term planning. One reason for this is the possible decreased availability of 15 kV equipment in the fixture. This, however, is very doubtful especially when taking into consideration the present use of 15 kV in some industrialized countries and the special conditions in Ethiopia which require the use of 20 kV equipment with 15 kV voltage level. Various system configurations in use in developing countries were reviewed. The study produced the idea of utilizing two-phase medium voltage spur lines in Ethiopia in addition to the present three-phase lines. They could be suitable for remote, light loaded locations with no or only light three-phase loads. Then also new single-phase transformers with smaller capacities than the present three-phase units would have to be introduced.

Lassila, A.; Lemma, S.

1991-12-31

345

Development of electricity distribution systems in developing countries  

Energy Technology Data Exchange (ETDEWEB)

This research has been implemented in cooperation with the Ethiopian Electric Light and Power Authority (EELPA). Its aim was to produce a means of optimizing the distribution systems in Ethiopia, but the results are also partly applicable in other countries where similar conditions prevail. The main target areas were the selection of a medium voltage, system configurations and neutral earthing methods. The medium voltage study was based on the theory and computer programs introduced in the previous stage of the project implemented at Tampere University of Technology. The practical studies were performed under Ethiopian conditions, and the results indicated that there is no reason to convert the present 15 kV medium voltage level to any other voltage level at the moment. Thus the option for gradual converting from 15 kV to 20 kV, which proved to be the best medium voltage level for future requirements, could be reserved for long-term planning. One reason for this is the possible decreased availability of 15 kV equipment in the fixture. This, however, is very doubtful especially when taking into consideration the present use of 15 kV in some industrialized countries and the special conditions in Ethiopia which require the use of 20 kV equipment with 15 kV voltage level. Various system configurations in use in developing countries were reviewed. The study produced the idea of utilizing two-phase medium voltage spur lines in Ethiopia in addition to the present three-phase lines. They could be suitable for remote, light loaded locations with no or only light three-phase loads. Then also new single-phase transformers with smaller capacities than the present three-phase units would have to be introduced.

Lassila, A.; Lemma, S.

1991-01-01

346

Development of the plutonium oxide vitrification system  

Energy Technology Data Exchange (ETDEWEB)

Repository disposal of plutonium in a suitable, immobilized form is being considered as one option for the disposition of surplus weapons-usable plutonium. Accelerated development efforts were completed in 1997 on two potential immobilization forms to facilitate downselection to one form for continued development. The two forms studied were a crystalline ceramic based on Synroc technology and a lanthanide borosilicate (LaBS) glass. As part of the glass development program, melter design activities and component testing were completed to demonstrate the feasibility of using glass as an immobilization medium. A prototypical melter was designed and built in 1997. The melter vessel and drain tube were constructed of a Pt/Rh alloy. Separate induction systems were used to heat the vessel and drain tube. A Pt/Rh stirrer was incorporated into the design to facilitate homogenization of the melt. Integrated powder feeding and off-gas systems completed the overall design. Concurrent with the design efforts, testing was conducted using a plutonium surrogate LaBS composition in an existing (near-scale) melter to demonstrate the feasibility of processing the LaBS glass on a production scale. Additionally, the drain tube configuration was successfully tested using a plutonium surrogate LaBS glass.

Marshall, K.M.; Marra, J.C.; Coughlin, J.T.; Calloway, T.B.; Schumacher, R.F.; Zamecnik, J.R.; Pareizs, J.M.

1998-01-01

347

Development of plant construction scheduling support system  

International Nuclear Information System (INIS)

A scheduling support system through knowledge-based man-machine cooperation has been developed for nuclear power plant construction. The proposed system, named NPCS, has three characteristic functions: (1) Automatic dissolution of constraint violations using a constraint-oriented programming technique; (2) Automatic resource leveling based on a combinatorial-optimization technique using heuristic rules on task ordering; (3) Display of a scheduling chart which facilitates interactive schedule modification performed by expert engineers. A scheduling process of NPCS consists of two steps. At the first steps, an initial schedule with leveled resource is built, and at the second step, the initial schedule is improved interactively, where constraint violations are dissolved automatically. NPCS was experimentally applied to solve about 80 scheduling problems in a nuclear power plant construction and confirmed to reduce the scheduling time and to improve the quality of the schedule. (author)

1991-01-01

348

Development of the Open Items Tracking System  

International Nuclear Information System (INIS)

The West Valley Demonstration Project, located on the site of the only commercial nuclear fuel reprocessing facility to have operated in USA, has the directed objectives of solidifying the high-level radioactive waste into a durable, solid form for shipment; decontaminating and decommissioning the tanks and facilities; and disposing of the resulting low-level and transuranic wastes. Since an escalating trend of open work items was noticed in the Fall of 1988, and there was no control mechanism for tracking and closing the open items, a Work Control System was developed for this purpose. It is self-contained system on a mainframe ARTEMIS 9000, which tracks, monitors, and closes out external commitments in a timely manner. Audits, surveillances, site appraisals, preventive maintenance, instrument calibration recall, and scheduling are covered.

1994-01-01

349

The development of a neurosurgical navigation system  

Energy Technology Data Exchange (ETDEWEB)

A Computer Assisted Neurosurgical Navigation System (CANS Navigator) has been developed, which assists neurosurgeons in surgery by utilizing images from highly advanced medical imaging devices. During a surgical procedure, the positional and directional information about the surgical, tools can be confirmed by observing their location on the CT or MR images on the CRT monitor. Applying magnetic field technology to position measurement, the position sensor attached to the surgical tool can be made small and light. As a result, no interference occurs with the surgical procedure. Performed on important fine vessels and nerves, neurosurgery requires precision techniques often lasting many hours. Therefore, the surgeons bear great loads physically and psychologically. Because understanding the location of the diseased part and the various organs can be made easy, the use of this system reduces the workload on surgeons and helps effect more accurate and safer surgery. (author).

Okumura, Takeshi; Okamura, Shoichi; Sasagawa, Tsuyoshi; Takemura, Kunihiko [Shimadzu Corp., Kyoto (Japan); Kato, Amami; Yoshimine, Toshiki; Nakajima, Shin; Hayakawa, Toru

1994-09-01

350

The development of a neurosurgical navigation system  

International Nuclear Information System (INIS)

[en] A Computer Assisted Neurosurgical Navigation System (CANS Navigator) has been developed, which assists neurosurgeons in surgery by utilizing images from highly advanced medical imaging devices. During a surgical procedure, the positional and directional information about the surgical, tools can be confirmed by observing their location on the CT or MR images on the CRT monitor. Applying magnetic field technology to position measurement, the position sensor attached to the surgical tool can be made small and light. As a result, no interference occurs with the surgical procedure. Performed on important fine vessels and nerves, neurosurgery requires precision techniques often lasting many hours. Therefore, the surgeons bear great loads physically and psychologically. Because understanding the location of the diseased part and the various organs can be made easy, the use of this system reduces the workload on surgeons and helps effect more accurate and safer surgery. (author)

1994-01-01

351

Reusable Metallic Thermal Protection Systems Development  

UK PubMed Central (United Kingdom)

Metallic thermal protection systems (TPS) are beingdeveloped to help meet the ambitious goals of futurereusable launch vehicles. Recent metallic TPS developmentefforts at NASA Langley Research Center are described.Foil-gage metallic honeycomb coupons, representative ofthe outer surface of metallic TPS were subjected to low speedimpact, hypervelocity impact, rain erosion, and subsequentarcjet exposure. TPS panels were subjected to thermalvacuum, acoustic, and hot gas flow testing. Results of thecoupon and panel tests are presented. Experimental andanalytical tools are being developed to characterize andimprove internal insulations. Masses of metallic TPS andadvanced ceramic tile and blanket TPS concepts arecompared for a wide range of parameters.1 . INTRODUCTIONFuture reusable launch vehicles (RLVs) will require greatlyimproved thermal protection systems (TPS) to achieve theambitious goal of reducing the cost of delivering a payloadto orbit by an order of magnitude. ...

Max L. Blosser; Carl J. Martin; Kamran Daryabeigi; Carl C. Poteet

352

Developing Information System on Lunar Crescent Observations  

Directory of Open Access Journals (Sweden)

Full Text Available We present a progress report on the development of information system of lunar crescent astronomical observations which will be largely accessible for public domain. This consists of calculations of the Moon’s ephemeris as well as systematic real-time lunar crescent observations. A well suited small telescope, equipped with a simple digital detector, is connected to a server to provide information on lunar crescent observations. The system has been used and worked well. The only constraint is poor weather condition. Network of small telescopes, installed at various locations in Indonesia, are currently planned to provide plethora of data. In the long term, this will be used to help to determine the astronomical visibility criteria of lunar crescent for Islamic calendar.

T. Hidayat; P. Mahasena; B. Dermawan; D. Herdiwijaya; H. Setyanto; M. Irfan; B. Suhardiman; A. Santoso

2010-01-01

353

New developments of the GANIL control system  

International Nuclear Information System (INIS)

Since its first ion beam, the GANIL accelerator has been driven by a Control System built around a minicomputer MITRA 125 and a distributed intelligence consisting of programmable Controllers and INTEL 8080 equipped autonomous CAMAC Controllers. After a brief description of the GANIL Control System, this paper will lay emphasis on the major improvements undertaken along four main directions: a) Upgrading the Control Computer. b) Introducing more powerful local intelligence. A microprocessorized autonomous CAMAC Controller called ''DIVA 68C'' using the 68000 microprocessor embedded in a VME card has been developed. Also, the 68000 will be used in a general purpose CAMAC module, the first application of which is to replace the existing data link modules. (c) Making human-machine dialog smarter with use of color graphic terminals. d) Meeting the requirements of the coming second injector. In this purpose a fully equipped auxiliary console is being installed near the main console for operation by summer 1985

1985-01-01

354

NANOTECHNOLOGY IN DEVELOPMENT OF DRUG DELIVERY SYSTEM  

Directory of Open Access Journals (Sweden)

Full Text Available Nanotechnology is science of matter and material that deal with particle size in nanometers. Nanotechnology has received a lot of attention with never-seen-before enthusiasm because of its future potential. It has provided fine lined diagnosis and focus treatment of disease at molecular level. This technology offers the advantage of protecting drugs from degradation; reduce the number of doses required. In this review, a discussion was carried out on different techniques for the preparation of nanodrug delivery systems like nanoparticles, solid lipid nanoparticles, nanocrystals, nanosuspensions, nanoemulsions. The concept of nanotechnology is widely expanded and applied to many drugs to the present. The ultimate application goal of nano drug delivery system is to develop clinically useful formulation for treating diseases in patients.

Vidyavathi Maravajhala et al.

2012-01-01

355

Biotechnology and food systems in developing countries.  

Science.gov (United States)

Even in a world with adequate food supplies in global markets, which is the situation today, biotechnology offers important opportunities to developing countries in four domains. First, many agronomically hostile or degraded environments require major scientific breakthroughs to become productive agricultural systems. Few of these breakthroughs are likely to be achieved through traditional breeding approaches. Second, biofortification offers the promise of greater quantities and human availabilities of micronutrients from traditional staple foods, with obvious nutritional gains for poor consumers, especially their children. Third, many high yielding agricultural systems are approaching their agronomic potential. Radically new technologies will be required to sustain productivity growth in these systems, and only modern genetic technology offers this hope. Finally, many cropping systems use large quantities of chemical inputs, such as herbicides, pesticides and fertilizers that can be unhealthy for people and soils alike. Biotechnology offers the potential to reduce the need for these inputs in economically and environmentally sustainable ways. Applying these new technologies to society's basic foods raises obvious concerns for both human and ecological health. For some, these concerns have become outright fear, and this has mobilized a backlash against genetically modified foods in any form. These concerns (and fears) must be addressed carefully and rationally so that the public understands the risks (which are not zero) and benefits (which might be enormous). Only the scientific community has the expertise and credibility to build this public understanding. PMID:14608038

Timmer, C Peter

2003-11-01

356

Development of hybrid hydrogen control system  

International Nuclear Information System (INIS)

[en] Catalytic recombiners disposing of hydrogen in severe accidents of nuclear power plants generally has a weak property for poison and steam environment. Spherical catalyst is robust for poison because of porosity with large specific area, but relatively weak for steam because of easily condensing steam by capillary phenomenon. Plate-type catalyst is conversely thought to be robust for steam but weak for poison. Hybrid hydrogen control system that consists of catalytic layers filled with spherical catalyst, barlike heater penetrating catalytic layers and covering box improves weakness of spherical catalyst by heating and also has function of an igniter. We first investigated the relation between resistance to steam and material sort with diameter of spherical catalyst to develop hybrid hydrogen control system. We verified that Pt in a small diameter was superior as recombiner catalyst. We successively carried out integrated tests by optimized catalytic layer shape to verily performance of hybrid hydrogen control system as a recombiner and an igniter. Hybrid hydrogen control system is prospected to be applied to commercial nuclear power plants. (author)

2000-01-01

357

Development of the High Energy Linac Systems  

International Nuclear Information System (INIS)

[en] The main purpose of this project is studying the extension plan of the proton engineering frontier project (PEFP) 100-MeV Linac. It includes three categories. One is studying operation plan of the PEFP linac and its extended accelerators, and developing a distribution system of 100-MeV proton beams with a laser striping. Other is designing superconducting RF (SRF) modules and fabricating and testing a copper cavity model. The other is designing a rapid cycling synchrotron (RCS). The operation scheme of the PEFP linac is related to the optimization in the operation of the 100-MeV linac, 200-MeV SRF, and RCS. We studied several operational method to increase the validity of the accelerators. The beam distribution system has two roles. One is supplying proton beams of 100 MeV to the user group. The laser stripping of the negative hydrogen atoms is used in this case. The other beams are directed to the next high energy accelerators. This study contributes to increase the availability of the proton beams. The SRF is one of candidates to extend the PEFP linac system. Since the accelerating gradient of the SRF is much higher than the normal conducting accelerator, a lot of institutes over the world are developing the SRF structure. Main purposes are designing an SRF module, fabricating and testing an copper model which has similar material properties as Nb of the usual SRF cavity material. The RCS is a synchrotron whose injector is the PEFP 100-MeV linac. Main purposes are determining the lattice structure, studying the fast and slow extraction system, simulating beam behavior in the designed synchrotron. The RCS will be used as the spallation neutron source and tools in the basic and applied science including medical application

2008-01-01

358

Microbolometer development and production at Indigo Systems  

Science.gov (United States)

While microbolometers have been in production for several years, the number of companies producing them is quite small. Indigo Systems has entered into the development and production of VOx based microbolometers, at its Goleta facility. Through the investment of significant capital, Indigo has established a high volume production facility based on the silicon industry model. The 6-inch, cassette-to-cassette, highly automated facility is capable of yielding hundreds of thousands of die per year. Discussed in the paper will be the design and layout of the facility, performance of the devices, as well as yield, trend and throughput data.

Terre, William A.; Cannata, Robert; Franklin, Patrick; Gonzalez, Alfredo; Kurth, Eric; Ly, Hiep; Parrish, William J.; Peters, Kevin; Romeo, Tommie; VanYsseldyk, Robert

2003-09-01

359

Development of a laundry radwaste treatment system  

Energy Technology Data Exchange (ETDEWEB)

Fundamental bench tests have been performed to develop a radioactive laundry radwaste treatment system, involving ozone/activated carbon, reverse osmosis membrane, and ion exchanger. A pre-treatment technique was employed for the removal of detergent, using a ozonization (ozone/H{sub 2}O{sub 2}). Adsorption of detergent and radionuclides by various commercial adsorbents and removal of radionuclides by reverse osmosis membrane have been investigated. The removal rates of radionuclides and/or detergents are presented for each process. (author)

Kim, J.B.; Park, J.K.; Park, S.M.; Ahn, H.J.; Song, M.J. [Korea Electric Power Corp., Research Institute, Taejon (Korea, Republic of)

1998-07-01

360

Development of PWR CRDM Data Analyzing System  

Energy Technology Data Exchange (ETDEWEB)

Control Rod Drive Mechanisms (CRDMs) play an important role in nuclear power plants, and their reliability impacts plant operation and reactor safety. CRDM performance might decline when the CRDM has been operated for a long time. CRDM operation time is expected to increase significantly depending on the variations of plant operation, so it is desirable to upgrade the preventive maintenance of CRDMs and Drive Lines through the periodic inspection and condition monitoring. Furthermore, in the case of CRDM malfunction, it is necessary to cope immediately with the problem, based on technical judgement. The CRDM Data Analyzing System has been developed in order to achieve the high reliability of CRDMs by predicting malfunctions. (author).

Miyaguchi, Jinichi (Mitsubishi Heavy Industries Ltd., Kobe (Japan). Kobe Shipbuilding and Engine Works)

1991-02-01

 
 
 
 
361

The electric system in China: its development  

International Nuclear Information System (INIS)

[en] This paper report many aspects related to the rapid development of electric power system in China[it] L'articolo delinea quanto trattato dall'autore, past President della Federazione AEIT, durante la conferenza, promossa dalla Sezione AEIT di Milano, svoltasi il 16 giugno 2005 a Milano e dal titolo Il pianeta Cina ed il suo sistema elettrico. l'ing. Clerici ha avuto l'opportunita di approfondire i vari aspetti relativi allo sviluppo del settore elettrico in Cina in occasione delle sue missioni ed incontri nel paese asiatico con i principali operatori del settore

362

Development Of NRU Reflector Wall Inspection System  

Directory of Open Access Journals (Sweden)

Full Text Available In 2009 May, the National Research Universal (NRU) calandria leaked. During the next year, the calandria was inspected with six new Non-Destructive Evaluation (NDE) techniques to determine the extent of the corrosion, repaired, and finally the repair was inspected with four additional new NDE techniques before the reactor was returned to service.The calandria is surrounded by a light-water reflector vessel fabricated from the same material as the calandria vessel. Concerns that the same corrosion mechanism had damaged the reflector vessel led to the development of a system to inspect the full circumference of the reflector wall for corrosion damage. The inspection region could only be accessed through 64 mm diameter ports, was 10 m below the port, and had to be inspected from the corroded surface. The ultrasonic technique was designed to produce a closely spaced wall thickness (WT) grid over an area of approximately 5 m2 on the corroded surface using a very small probe holder.This paper describes the Reflector Wall Inspection (RWI)development project and the system that resulted

R. Lumsden; B.V. Luloff; N. Zahn; N. Simpson

2013-01-01

363

Development and Control of a Non Linear Magnetic Levitation System  

Directory of Open Access Journals (Sweden)

Full Text Available Nowadays, studies to develop and control non linear systems is of great significance. Magnetic Levitation System has gained considerable interests due to its great practical importance in different engineering fields In this paper an electromagnetic levitation system was developed and mathematical model for the system was derived. The developed system was controlled manually.

Reshma Angelene Jose; A Sanjeevi Gandhi

2013-01-01

364

Development of tritium cleanup system for LHD  

International Nuclear Information System (INIS)

Energy is vital for humans and we have been consuming a large amount of fossil fuel especially from the beginning of the industrial revolution. Nowadays its huge consumption has however come to threaten our life and we have to prepare nonfossil fuels, for instance solar energy, biomass energy, nuclear energy and so on. Fusion energy is an unlimited resource and one of the strongest candidates of the future energy source. At the National Institute for Fusion Science (referred to as 'NIFS' hereafter), we have constructed a new fusion experimental device called large helical device (referred to as 'LHD' hereafter) in 1998. The device will generate a small amount of tritium, as a fusion product. In order to remove it from the exhaust gas, we have designed a tritium cleanup system based on a new concept. This system is mainly composed of a palladium permeater, a decomposer and hydrogen absorbing alloys. It may perfectly recover the tritium from exhaust gas without oxidizing it. This system is applicable for the future needs at fusion power plants. In order to remove tritium discharged from fusion experimental facilities, it is usual to employ a system by which tritiated constituents, in various chemical forms, are entirely converted to a form of water vapor by catalytic oxidation. The water vapor containing tritiated form is then absorbed by molecular sieve (referred to as 'wet system' hereafter). However, in the case of LHD, it is not rational to deliberately convert the discharged tritium into the water vapor, because the tritium discharged from LHD is almost in a form of hydrogen molecules. Moreover, the tritium in the form of water vapor affects the human body 18000 times stronger than that of hydrogen molecules. In accordance with these view points, we have developed another type of tritium cleanup system based on a new concept, in which hydrogen molecules including tritiated ones (HT, DT and T2) found in the exhaust gas of LHD are directly fixed to hydrogen absorbing alloys. Other impurities such as methane and water vapor, parts of which are tritiated, will be decomposed into each elemental form by the decomposition process and hydrogen molecules, including tritiated constituents from the decomposition (referred to as 'dry system' hereafter).

2000-01-01

365

Development of multichannel MEG system at IGCAR  

Science.gov (United States)

We describe some of the challenging aspects in the indigenous development of the whole head multichannel magnetoencephalography (MEG) system at IGCAR, Kalpakkam. These are: i) fabrication and testing of a helmet shaped sensor array holder of a polymeric material experimentally tested to be compatible with liquid helium temperatures, ii) the design and fabrication of the PCB adapter modules, keeping in mind the inter-track cross talk considerations between the electrical leads used to provide connections from SQUID at liquid helium temperature (4.2K) to the electronics at room temperature (300K) and iii) use of high resistance manganin wires for the 86 channels (86×8 leads) essential to reduce the total heat leak which, however, inevitably causes an attenuation of the SQUID output signal due to voltage drop in the leads. We have presently populated 22 of the 86 channels, which include 6 reference channels to reject the common mode noise. The whole head MEG system to cover all the lobes of the brain will be progressively assembled when other three PCB adapter modules, presently under fabrication, become available. The MEG system will be used for a variety of basic and clinical studies including localization of epileptic foci during pre-surgical mapping in collaboration with neurologists.

Mariyappa, N.; Parasakthi, C.; Gireesan, K.; Sengottuvel, S.; Patel, Rajesh; Janawadkar, M. P.; Radhakrishnan, T. S.; Sundar, C. S.

2013-02-01

366

Web-based Core Design System Development  

International Nuclear Information System (INIS)

The selection of a loading pattern is one of core design processes in the operation of a nuclear power plant. A potential new loading pattern is identified by selecting fuels that to not exceed the major limiting factors of the design and that satisfy the core design conditions for employing fuel data from the existing loading pattern of the current operating cycle. The selection of a loading pattern is also related to the cycle plan of an operating nuclear power plant and must meet safety and economic requirements. In selecting an appropriate loading pattern, all aspects, such as input creation, code runs and result processes are processed as text forms manually by a designer, all of which may be subject to human error, such as syntax or running errors. Time-consuming results analysis and decision-making processes are the most significant inefficiencies to avoid. A web-based nuclear plant core design system was developed here to remedy the shortcomings of an existing core design system. The proposed system adopts the general methodology of OPR1000 (Korea Standard Nuclear Power Plants) and Westinghouse-type plants. Additionally, it offers a GUI (Graphic User Interface)-based core design environment with a user-friendly interface for operators. It reduces human errors related to design model creation, computation, final reload core model selection, final output confirmation, and result data validation and verification. Most significantly, it reduces the core design time by more than 75% compared to its predecessor

2011-01-01

367

Web-based Core Design System Development  

Energy Technology Data Exchange (ETDEWEB)

The selection of a loading pattern is one of core design processes in the operation of a nuclear power plant. A potential new loading pattern is identified by selecting fuels that to not exceed the major limiting factors of the design and that satisfy the core design conditions for employing fuel data from the existing loading pattern of the current operating cycle. The selection of a loading pattern is also related to the cycle plan of an operating nuclear power plant and must meet safety and economic requirements. In selecting an appropriate loading pattern, all aspects, such as input creation, code runs and result processes are processed as text forms manually by a designer, all of which may be subject to human error, such as syntax or running errors. Time-consuming results analysis and decision-making processes are the most significant inefficiencies to avoid. A web-based nuclear plant core design system was developed here to remedy the shortcomings of an existing core design system. The proposed system adopts the general methodology of OPR1000 (Korea Standard Nuclear Power Plants) and Westinghouse-type plants. Additionally, it offers a GUI (Graphic User Interface)-based core design environment with a user-friendly interface for operators. It reduces human errors related to design model creation, computation, final reload core model selection, final output confirmation, and result data validation and verification. Most significantly, it reduces the core design time by more than 75% compared to its predecessor.

Moon, So Young; Kim, Hyung Jin [Atomic Creative Technology Co., Daejeon (Korea, Republic of); Yang, Sung Tae; Hong, Sun Kwan [Korea Hydro and Nuclear Power Co., Daejeon (Korea, Republic of)

2011-08-15

368

Power Systems Development Facility. Environmental Assessment  

Energy Technology Data Exchange (ETDEWEB)

The objective of the PSDF would be to provide a modular facility which would support the development of advanced, pilot-scale, coal-based power systems and hot gas clean-up components. These pilot-scale components would be designed to be large enough so that the results can be related and projected to commercial systems. The facility would use a modular approach to enhance the flexibility and capability for testing; consequently, overall capital and operating costs when compared with stand-alone facilities would be reduced by sharing resources common to different modules. The facility would identify and resolve technical barrier, as well as-provide a structure for long-term testing and performance assessment. It is also intended that the facility would evaluate the operational and performance characteristics of the advanced power systems with both bituminous and subbituminous coals. Five technology-based experimental modules are proposed for the PSDF: (1) an advanced gasifier module, (2) a fuel cell test module, (3) a PFBC module, (4) a combustion gas turbine module, and (5) a module comprised of five hot gas cleanup particulate control devices. The final module, the PCD, would capture coal-derived ash and particles from both the PFBC and advanced gasifier gas streams to provide for overall particulate emission control, as well as to protect the combustion turbine and the fuel cell.

1993-06-01

369

Development of the environmental neutron detection system  

CERN Multimedia

Environmental neutron detection system is proposed. The main goal of this system was set to detect fast and thermal neutrons with the identical detector setup without degraders. A detector setup for the system with a sup 1 sup 0 B doped liquid scintillator, which had been optimized for thermal neutron counting in last year, was developed first. For optimization of for fast neutron counting, density of sup 1 sup 0 B and the size of the detector were fixed by measurement of fast neutrons, with help of the Monte Carlo calculation. In the meantime, possibility of the use of inorganic scintillators in neutron counting were verified, to solve the problem occurring at the long term use of the organic liquid scintillators. The detectors checked were LSO, BaF sub 2 , BGO and GSO. LSO and BaF sub 2 have much more difficulties in neutron counting such as background counting rates and BGO has some unclear signals at neutron measurements. GSO was shown to be the most probable candidate among them at the measurement of neu...

Kume, K

2003-01-01

370

Development of CANDU core monitoring system  

International Nuclear Information System (INIS)

[en] The research was performed to develop a CANDU Core Monitoring System(CCMS) that enables operators to have efficient core management by monitoring core power distribution, burnup distribution, and the other important core variables and managing the past core history for Wolsong Nuclear Power Plant(NPP) No. 1. CCMS uses RFSP(Reactor Fueling Simulation Program) for continuous core calculation by integrating the algorithm and assumptions validated and uses the information taken from DCC(Digital Control Computer) for the purpose of producing basic input data. CCMS could be largely divided into two modules; CCMS server program and CCMS client program. CCMS server program plays the role in automatic and continuous RFSP run and management of the past output data resulting from the run using Data Base Management System(DBMS). CCMS client program enables users to monitor current and past core status with GUI(Graphic-User Interface) environment predefined. The effectiveness of CCMS was verified by comparing the data resulted from field-test of the system for about 43 hours with the data used in the field of Wolsong NPP No. 1

2003-01-01

371

Development of CANDU core monitoring system  

Energy Technology Data Exchange (ETDEWEB)

The research was performed to develop a CANDU Core Monitoring System(CCMS) that enables operators to have efficient core management by monitoring core power distribution, burnup distribution, and the other important core variables and managing the past core history for Wolsong Nuclear Power Plant(NPP) No. 1. CCMS uses RFSP(Reactor Fueling Simulation Program) for continuous core calculation by integrating the algorithm and assumptions validated and uses the information taken from DCC(Digital Control Computer) for the purpose of producing basic input data. CCMS could be largely divided into two modules; CCMS server program and CCMS client program. CCMS server program plays the role in automatic and continuous RFSP run and management of the past output data resulting from the run using Data Base Management System(DBMS). CCMS client program enables users to monitor current and past core status with GUI(Graphic-User Interface) environment predefined. The effectiveness of CCMS was verified by comparing the data resulted from field-test of the system for about 43 hours with the data used in the field of Wolsong NPP No. 1.

Yoon, M. Y.; Yeam, C. S.; Kwon, O. H.; Kim, K. H. [Institute for Advanced Engineering, Yongin (Korea, Republic of)

2003-07-01

372

Time fractional development of quantum systems  

Science.gov (United States)

In this study, the effect of time fractionalization on the development of quantum systems is taken under consideration by making use of fractional calculus. In this context, a Mittag-Leffler function is introduced as an important mathematical tool in the generalization of the evolution operator. In order to investigate the time fractional evolution of the quantum (nano) systems, time fractional forms of motion are obtained for a Schrödinger equation and a Heisenberg equation. As an application of the concomitant formalism, the wave functions, energy eigenvalues, and probability densities of the potential well and harmonic oscillator are time fractionally obtained via the fractional derivative order ?, which is a measure of the fractality of time. In the case ?=1, where time becomes homogenous and continuous, traditional physical conclusions are recovered. Since energy and time are conjugate to each other, the fractional derivative order ? is relevant to time. It is understood that the fractionalization of time gives rise to energy fluctuations of the quantum (nano) systems.

Ertik, Hüseyin; Demirhan, Do?an; ?irin, Hüseyin; Büyükk?l?ç, Fevzi

2010-08-01

373

Time fractional development of quantum systems  

International Nuclear Information System (INIS)

[en] In this study, the effect of time fractionalization on the development of quantum systems is taken under consideration by making use of fractional calculus. In this context, a Mittag-Leffler function is introduced as an important mathematical tool in the generalization of the evolution operator. In order to investigate the time fractional evolution of the quantum (nano) systems, time fractional forms of motion are obtained for a Schroedinger equation and a Heisenberg equation. As an application of the concomitant formalism, the wave functions, energy eigenvalues, and probability densities of the potential well and harmonic oscillator are time fractionally obtained via the fractional derivative order ?, which is a measure of the fractality of time. In the case ?=1, where time becomes homogenous and continuous, traditional physical conclusions are recovered. Since energy and time are conjugate to each other, the fractional derivative order ? is relevant to time. It is understood that the fractionalization of time gives rise to energy fluctuations of the quantum (nano) systems.

2010-01-01

374

Development of novel emission tomography system  

Science.gov (United States)

In recent years, small animals, such as mice and rats, have been widely used as subjects of study in biomedical research while molecular biology and imaging techniques open new opportunities to investigate disease model. With the help of medical imaging techniques, researchers can investigate underlying mechanisms inside the small animal, which are useful for both early diagnosis and treatment monitoring. Based on tracer principle single photon emission computed tomography (SPECT) has increased popularity in small animal imaging due to its higher spatial resolution and variety of single-photon emitting radionuclides. Since the image quality strongly depends on the detector properties, both scintillation and semiconductor detectors are under active investigation for high resolution X-ray and gamma ray photon detection. The desired detector properties include high intrinsic spatial resolution, high energy resolution, and high detection efficiency. In this thesis study, we have made extensive efforts to develop novel emission tomography system, and evaluate the use of both semiconductor and ultra-high resolution scintillation detectors for small animal imaging. This thesis work includes the following three areas. Firstly, we have developed a novel energy-resolved photon counting (ERPC) detector. With the benefits of high energy resolution, high spatial resolution, flexible detection area, and a wide dynamic range of 27--200keV, ERPC detector is well-suited for small animal SPECT applications. For prototype ERPC detector excellent imaging (˜350microm) and spectroscopic performance (4keV Co-57 122keV) has been demonstrated in preliminary study. Secondly, to further improve spatial resolution to hundred-micron level, an ultra-high resolution Intensified EMCCD (I-EMCCD) detector has been designed and evaluated. This detector consists of the newly developed electron multiplying CCD (EMCCD) sensor, columnar CsI(Tl) scintillator, and an electrostatic de-magnifier (DM) tube. The detector offers the combination of an excellent intrinsic spatial resolution, a good signal-to-noise ratio (SNR), a large active area, and reasonable detection efficiency over the energy range from 27 to 140 keV. Based on I-EMCCD detector we developed a prototype dual-head single photon emission microscope (SPEM) system for mouse imaging. Both phantom and animal imaging experiments have been performed to evaluate system capabilities for ultra-high resolution SPECT imaging. In addition, we have presented a feasibility study of using emission tomography system for synchrotron X-ray fluorescence computer tomography (XFCT). Based on high resolution semiconductor detector and collimation aperture, X-ray fluorescence emission tomography (XFET) can offer more imaging information content by each detected photon and allow less scanning motion, which help to overcome the hurdle for current X-ray fluorescence computed tomography (XFCT) and improve imaging speed. CCD-based emission tomography system has been set up at the Advanced Photon Source (APS) for phantom and animal imaging. It has demonstrated that XFET is capable of acquiring 3D element distribution with a greatly improved imaging speed. Key words: SPECT, ERPC, I-EMCCD, SPEM, APS, and XFET

Fu, Geng

375

The development of KAERI management information system (II) -The development of Time Sheet Management System-  

International Nuclear Information System (INIS)

The purpose of this report is to describe the work done for the development, operation and maintenance of Time Sheet Management System. This work is a part of the development KAERI management information system. Manpower management is essential to cope with the external circumstances promptly and to maximize the productivity of the organization. This work aims at setting up a basis for the manpower management system. It is widely recognized that neither timely decision making nor competitive edge can be secured with the traditional management technology in so a rapidly changing situations home and abroad, which can be characterized by openness and informality. The necessity of efficient and scientific man-power management by time-study has emerged on the reorganization of KAERI by expanding matrix system in order to enhance the R and D productivity. (Author)

1994-01-01

376

Grid infrastructures for developing mammography CAD systems.  

UK PubMed Central (United Kingdom)

This paper presents a set of technologies developed to exploit Grid infrastructures for breast cancer CAD, that include (1) federated repositories of mammography images and clinical data over Grid storage, (2) a workstation for mammography image analysis and diagnosis and (3) a framework for data analysis and training machine learning classifiers over Grid computing power specially tuned for medical image based data. An experimental mammography digital repository of approximately 300 mammograms from the MIAS database was created and classifiers were built achieving a 0.85 average area under the ROC curve in a dataset of 100 selected mammograms with representative pathological lesions and normal cases. Similar results were achieved with classifiers built for the UCI Breast Cancer Wisconsin dataset (699 features vectors). Now these technologies are being validated in a real medical environment at the Faculty of Medicine in Porto University after a process of integrating the tools within the clinicians workflows and IT systems.

Ramos-Pollan R; Franco JM; Sevilla J; Guevara-Lopez MA; de Posada NG; Loureiro J; Ramos I

2010-01-01

377

Grid infrastructures for developing mammography CAD systems.  

Science.gov (United States)

This paper presents a set of technologies developed to exploit Grid infrastructures for breast cancer CAD, that include (1) federated repositories of mammography images and clinical data over Grid storage, (2) a workstation for mammography image analysis and diagnosis and (3) a framework for data analysis and training machine learning classifiers over Grid computing power specially tuned for medical image based data. An experimental mammography digital repository of approximately 300 mammograms from the MIAS database was created and classifiers were built achieving a 0.85 average area under the ROC curve in a dataset of 100 selected mammograms with representative pathological lesions and normal cases. Similar results were achieved with classifiers built for the UCI Breast Cancer Wisconsin dataset (699 features vectors). Now these technologies are being validated in a real medical environment at the Faculty of Medicine in Porto University after a process of integrating the tools within the clinicians workflows and IT systems. PMID:21097026

Ramos-Pollan, Raul; Franco, Jose M; Sevilla, Jorge; Guevara-Lopez, Miguel A; de Posada, Naimy Gonzalez; Loureiro, Joanna; Ramos, Isabel

2010-01-01

378

Development of centralized ALARA meetings registration system  

International Nuclear Information System (INIS)

Effective implementation of a radiological surveillance program in an NPP is one of the important aspects of the radiological safety management. This is achieved through the philosophy of ALARA. At Rajasthan Atomic Power Station (RAPS) - 3 and 4 there is a well-established ALARA organization and conduction of ALARA meetings is an integral part of it. Need was felt to have a centralized system for registration of ALARA meetings so that maximum benefit of these could be extracted. Inputs, flow of information and logics were provided to information and technology group at RAPS - 3 and 4 to develop a software program. This program is unique and provides opportunities to get required benefits of ALARA meetings conducted at the station. (author)

2008-01-01

379

Development of nuclear data base system  

International Nuclear Information System (INIS)

[en] Following scope of tasks are performed to establish the nuclear data base which is the infra structure for the nuclear related research and industry. - Upgrade of Table of Nuclides web service and addition of new feature to existing ENDF plotting services. - Establishment of nuclear structures data base. Reconstruction of nuclear structure (ENSDF) data base with up-to-date data. - Establishment of nuclear reaction data base. Collection of the experimental reaction database (EXFOR). Collection of the evaluated nuclear reaction data libraries. Development of data retrieval programs. - Group constant library generation and verification. Generation of MATXS group constant library for thermal reactor application and verification against U-235 cores. Improvement of the cross section library preparation system for the MCNP code. (author). 15 refs., 8 tabs., 8 figs

1998-01-01

380

Development of PWR CRDM Data Analyzing System  

International Nuclear Information System (INIS)

[en] Control Rod Drive Mechanisms (CRDMs) play an important role in nuclear power plants, and their reliability impacts plant operation and reactor safety. CRDM performance might decline when the CRDM has been operated for a long time. CRDM operation time is expected to increase significantly depending on the variations of plant operation, so it is desirable to upgrade the preventive maintenance of CRDMs and Drive Lines through the periodic inspection and condition monitoring. Furthermore, in the case of CRDM malfunction, it is necessary to cope immediately with the problem, based on technical judgement. The CRDM Data Analyzing System has been developed in order to achieve the high reliability of CRDMs by predicting malfunctions. (author)

1991-01-01

 
 
 
 
381

Design and Development of Robot Hand System  

Directory of Open Access Journals (Sweden)

Full Text Available Research on robot hand design is being carried out to accommodate a variety of tasks such as grasping and manipulation of objects in the field of industrial applications, service robots and rehabilitation robots. Problem statement: To design and develop a microcontroller-based four fingered robotic hand with a simple and minimal control strategy to pick and place application with object detection by simple IR sensor logic. Approach: The methodology is based on anthropomorphic design with three fingers and an opposing thumb. Each finger has three links and three double revolute joints. Each finger is actuated by a single opposing pair of tendons. The robot hand system is interfaced to microcontroller with software control by means of 14 independent commands for the motion of joints: close and open for fore finger, middle finger, ring finger and thumb finger and wrist up and down, base clockwise and counter clockwise, pick and place and home position. The tendoning system and wireless feedback logic provide the hand with the ability to confirm to object topology and therefore providing the advantage of using a simple control structure. Results: Reliable grasping and releasing is achieved with simple control mechanisms and IR sensors/push-button switches. The hand can pick a variety of objects with different surface characteristics and shapes without having to reconstruct its surface description. Picking of the object is successfully completed as long as the object is within the workspace of the hand and placed the object at the desired position within the workspace by relevant software control using keyboard commands. Conclusion: Hardware and software development of microcontroller-based four-fingered robotic hand is addressed. Details of hand control software for mainly pick and place applications are presented. Results of the experimental work for pick and place application of different objects is enumerated.

Panchumarthy Seetharamaiah; Mandapati V. Rao; Geddapu V. Satyanarayana

2011-01-01

382

Development of portable driving simulator system  

Directory of Open Access Journals (Sweden)

Full Text Available Purpose: In accordance with aging of populations in many developed countries, number of drivers who suffer from mild cognitive impairment (MCI drivers) is increasing. Since it has been reported that driving skill of the MCI drivers are deteriorated, it is important to train themselves in driving situation to preserve their driving skills. The present study was conducted to develop the simple driving simulator system, and to examine the effect of training in this system.Design/methodology/approach: Nineteen university students (8 males and 11 females) participated in this study. After the habituation period (approximately 5min), three trials (approximately 12 min) were conducted. Experimental situation imitated the real highway course. During trials, dangerous situation that would be resulted in car accident is randomly appeared and participants were required to avoid the car accidents. To avoid the possible car accidents are considered as correct response.Findings: Mean percent of correct responses for male and female were 75.2% and 56.6% in 1st trial and 95.7% and 72.6% in 3rd trial, respectively. Two-way analysis of variance revealed that the main effect of sex(F (1, 14) = 7.84, p < .05) and trials (F (2, 34) = 10.19, p < .001). These results indicate that numbers of car accidents are dramatically decreased and the driving skills of male are superior to that of female.Practical implications: Although the present study revealed the differences in driving skills between the sexes, their driving history was not considered. Driving history of each participant should be examined in future study.Originality/value: Since the improvement of driving skills is revealed, our experimental design is expected as the tool for the preservation of driving skills in the MCI drivers.

S. Yanai; Y. Itoh; T. Nemoto; M. Kihira; H. Matsuura

2008-01-01

383

Coal-log pipeline system development  

Energy Technology Data Exchange (ETDEWEB)

The objective of this study is to demonstrate that the amount of binder in coal logs can be reduced to 8% or below to produce logs with adequate strength to eliminate breakage during pipeline transportation under conditions experienced in long distance pipeline system. In addition the study will perform the necessary development to demonstrate a small model of the most promising injection system for coal-logs; test the logs from Task 1; conduct economic analysis of coal-log pipeline, based upon the work to date; and refine and complete the economic model. A detailed literature search in coal agglomeration has been conducted. This includes all the known previous attempts to agglomerate coal. Some important findings are listed. Some very preliminary tests have been done on making coal logs with and without binder. A small-scale demonstration unit of a coal log pipeline (CLP) has been designed. It uses 1 1/4-inch transparent plastic pipe and the loop is approximately 128 feet in length. The design is shown in a figure; construction has not begun as yet. 1 fig.

1990-01-01

384

Development of advanced reprocessing system 'FLUOREX'  

International Nuclear Information System (INIS)

The nuclear fuel reprocessing technology 'FLUOREX' is a hybrid system that combines fluoride volatility and solvent extraction methods, where the major U in spent fuel is separated as UF6 gas efficiently by the fluoride volatility method and MOX is recovered by well-established conventional PUREX like process which, however, does not have uranium-plutonium partitioning part for strong proliferation resistance. The system can recover pure U and MOX with a decontamination factor of over 107 and can drastically reduce costs compared with the conventional one. From 2001 to 2004, we carried out the examination for the fundamental process of FLUOREX. The investigation have been continued from 2004 to 2007 from the viewpoint of the engineering of flame reactor control, the development of systems such as decladding, UF6 purification including the trace Pu recovery process using UO2F2 adsorbent, and the conversion of MOX resources, and the influence of fluorine on the dissolution and extraction processes. We concluded that from those experimental results, key processes of FLUOREX are fundamentally proved. From 2008 to 2010, we carried out the important investigation for advanced stage of UF6 purification, recovery of PuF6, conversion of fluoride FPs to oxide, and effect of fluorine on material in the solvent extraction process. The UF6 purification process was examined in the semi-engineering scale using a flame reactor and absorbent traps. We got the prospect for UF6 purification using fluoride absorbents such as NaF and MgF2. We studied recovery of PuF6 by UO2F2 absorbent in small apparatus using Pu, Np and Tc. The engineering scale test of oxide conversion demonstrated that the rotary kiln was applicable for conversion process of non-volatile fluoride FPs to oxides. Effect of fluorine on material in the solvent extraction was examined with corrosion test and electrochemical analysis. These results demonstrated the applicability of FLUOREX to new generation reprocessing. (author)

2011-01-01

385

Development of the excretory system in a polyplacophoran mollusc: stages in metanephridial system development  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Two types of excretory systems, protonephridia and metanephridial systems are common among bilaterians. The homology of protonephridia of lophotrochozoan taxa has been widely accepted. In contrast, the homology of metanephridial systems – including coelomic cavities as functional units – among taxa as well as the homology between the two excretory systems is a matter of ongoing discussion. This particularly concerns the molluscan kidneys, which are mostly regarded as being derived convergently to the metanephridia of e.g. annelids because of different ontogenetic origin. A reinvestigation of nephrogenesis in polyplacophorans, which carry many primitive traits within molluscs, could shed light on these questions. Results The metanephridial system of Lepidochitona corrugata develops rapidly in the early juvenile phase. It is formed from a coelomic anlage that soon achieves endothelial organization. The pericardium and heart are formed from the central portion of the anlage. The nephridial components are formed by outgrowth from lateral differentiations of the anlage. Simultaneously with formation of the heart, podocytes appear in the atrial wall of the pericardium. In addition, renopericardial ducts, kidneys and efferent nephroducts, all showing downstream ciliation towards the internal lumen, become differentiated (specimen length: 0.62 mm). Further development consists of elongation of the kidney and reinforcement of filtration and reabsorptive structures. Conclusions During development and in fully formed condition the metanephridial system of Lepidochitona corrugata shares many detailed traits (cellular and overall organization) with the protonephridia of the same species. Accordingly, we suggest a serial homology of various cell types and between the two excretory systems and the organs as a whole. The formation of the metanephridial system varies significantly within Mollusca, thus the mode of formation cannot be used as a homology criterion. Because of similarities in overall organization, we conclude that the molluscan metanephridial system is homologous with that of the annelids not only at the cellular but also at the organ level.

Baeumler Natalie; Haszprunar Gerhard; Ruthensteiner Bernhard

2012-01-01

386

Cask systems development program seal technology  

Energy Technology Data Exchange (ETDEWEB)

General design or test performance requirements for radioactive materials (RAM) packages are specified in Title 10 of the US Code of Federal Regulations Part 71 (10 CFR 71). Seals that provide the containment system interface between the packaging body and the closure must function in both high- and low-temperature environments under dynamic and static conditions. Experiments were performed to characterize the performance of several seal materials at low temperatures. Helium leak tests on face seals were used to compare the materials. Materials tested include butyl, neoprene, ethylene propylene, fuorosilicone, silicone, Eypel, Kalrez, Teflon, fluorocarbon, and Teflon/silicone composites. Results show that the seal materials tested, with the exception of silicone S613-60, are not leak tight at manufacturer low-temperature ratings. This paper documents the initial series of experiments developed to characterize the performance of several static seals under conditions representative of RAM transport container environments. Helium leak rates of face seals were measured at low and ambient temperatures to compare seal materials. As scaling laws have not been developed for seals, the leakage rates measured in this program are intended to be used in a qualitative rather than quantitative manner. 5 refs., 7 figs., 2 tabs.

Madsen, M.M.; Edwards, K.R.; Humphreys, D.L.

1991-01-01

387

Developing a systemic program for compassion fatigue.  

Science.gov (United States)

The effort in hospitals to improve the patient experience has yielded a new impetus to address compassion fatigue (CF), a combination of secondary traumatic stress and burnout. Over the last 3 years, Barnes-Jewish Hospital has developed a systemic program for CF resiliency. An initial evaluation of the extent to which CF was affecting the hospital's oncology staff led to the formal implementation of a resiliency program for oncology registered nurses. The success of that program ultimately led to the implementation of a hospital-wide resiliency program, designed to help professional caregivers understand CF, recognize the physical, mental, and emotional effects of stress, and adopt resiliency strategies. The voluntary program has been very well received by participants, and a formal evaluation shows promising results with a decline in secondary traumatic stress and burnout among participants. Developing an institutional culture of recognition and support for CF is critical for health care organizations. Establishing such a culture may help managers proactively create work environments that provide opportunities for connection and support among staff. Compassion fatigue training allows professional caregivers to reconnect to their personal mission and then truly begin to connect with an organization's values and mission. PMID:24022286

Potter, Patricia; Deshields, Teresa; Rodriguez, Sean

388

Development of generation IV nuclear energy systems  

International Nuclear Information System (INIS)

The fifth 'Generation IV International Forum (GIF), Policy Group Meetings' was held at the Zen-Nikku Hotel in Tokyo, on September 19-20, 2002, under participations of Abraham, Secretary of DOE in U.S.A., Columbani, Secretary of CEA in France, Fujiie, Chairman of CAE in Japan, Kano, Parliamental Minister of MIS in Japan, and so on. Ten nations entering GIF (Argentina, Brazil, Canada, France, Japan, Korea, South Africa, Switzerland, U.K., and U.S.A.) selected six next generation nuclear energy concepts for objects of international cooperative research and development aiming at its practice by 2030. These concepts applicable to not only power generation, but also hydrogen production, sea water purification, and so on, are sodium liquid metal cooled reactor (Japan), high temperature gas cooled reactor (France), Super-critical pressure water cooled reactor (SCWR: Canada), Lead metal cooled reactor (Switzerland), Gas cooled fast reactor (U.S.A.), and molten salts reactor. On the generation IV nuclear reactor systems aiming to further upgrade their sustainability, safety, economical efficiency, and nuclear non proliferation, the 'Plans on Technical Development' (Road-map) to decide priority of their R and Ds has been cooperatively discussed under frameworks of international research cooperation by the GIF members nations. Here were shared descriptions on nuclear fuel cycle as a remise of technical evaluation and adopted concepts by Japanese participants contributing to making up the Road-map. (G.K.)

2003-01-01

389

Developing Higher-Order Materials Knowledge Systems  

Science.gov (United States)

Advances in computational materials science and novel characterization techniques have allowed scientists to probe deeply into a diverse range of materials phenomena. These activities are producing enormous amounts of information regarding the roles of various hierarchical material features in the overall performance characteristics displayed by the material. Connecting the hierarchical information over disparate domains is at the crux of multisc