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Study protocol. ECSSIT - Elective Caesarean Section Syntocinon Infusion Trial. A multi-centre randomised controlled trial of oxytocin (Syntocinon) 5 IU bolus and placebo infusion versus oxytocin 5 IU bolus and 40 IU infusion for the control of blood loss at elective caesarean section.  

LENUS (Irish Health Repository)

BACKGROUND: Caesarean section is one of the most commonly performed major operations in women throughout the world. Rates are escalating, with studies from the United States of America, the United Kingdom, China and the Republic of Ireland reporting rates between 20% and 25%. Operative morbidity includes haemorrhage, anaemia, blood transfusion and in severe cases, maternal death. The value of routine oxytocics in the third stage of vaginal birth has been well established and it has been assumed that these benefits apply to caesarean delivery as well. A slow bolus dose of oxytocin is recommended following delivery of the baby at caesarean section. Some clinicians use an additional infusion of oxytocin for a further period following the procedure. Intravenous oxytocin has a very short half-life (4-10 minutes) therefore the potential advantage of an oxytocin infusion is that it maintains uterine contractility throughout the surgical procedure and immediate postpartum period, when most primary haemorrhages occur. The few trials to date addressing the optimal approach to preventing haemorrhage at caesarean section have been under-powered to evaluate clinically important outcomes. There has been no trial to date comparing the use of an intravenous slow bolus of oxytocin versus an oxytocin bolus and infusion. METHODS AND DESIGN: A multi-centre randomised controlled trial is proposed. The study will take place in five large maternity units in Ireland with collaboration between academics and clinicians in the disciplines of obstetrics and anaesthetics. It will involve 2000 women undergoing elective caesarean section after 36 weeks gestation. The main outcome measure will be major haemorrhage (blood loss >1000 ml). A study involving 2000 women will have 80% power to detect a 36% relative change in the risk of major haemorrhage with two-sided 5% alpha. DISCUSSION: It is both important and timely that we evaluate the optimal approach to the management of the third stage at elective caesarean section. Safe operative delivery is now a priority and a reality for many pregnant women. Obstetricians, obstetric anaesthetists, midwives and pregnant women need high quality evidence on which to base management approaches. The overall aim is to reduce maternal haemorrhagic morbidity and its attendant risks at elective caesarean section. TRIAL REGISTRATION: number: ISRCTN17813715.

Murphy, Deirdre J

2009-01-01

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ECSSIT - Elective caesarean section Syntocinon infusion trial a multi-centre randomized controlled trial oxytocin Syntocinon % iu bolus and placebo infusion versus oxtocin 5 iu bolus and 40 iu infusion for the control of blood loss at elective caesarean section  

LENUS (Irish Health Repository)

Institute of Obstetricians & Gynaecologists, RCPI Four Provinces Meeting, Junior Obstetrics & Gynaecology Society Annual Scientific Meeting, Royal Academy of Medicine in Ireland Dublin Maternity Hospitals Reports Meeting, Nov 2010

Sheehan, S

2011-02-01

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Where does ergometrine stand in prevention of postpartum haemorrhage in caesarean section  

International Nuclear Information System (INIS)

Objective: To compare the safety and efficacy of 10 units of intravenous syntocinon alone with 10 units intravenous syntocinon and 0.25 mg intramuscular ergometrine in the prevention of atonic uterine haemorrhage during caesarean section. Method: The quasi-experimental study was conducted at the Maternal and Child Health Centre, Unit I, Pakistan Institute of Medical Sciences, Islamabad, from November 1, 2010 to February 28, 2011. All women undergoing caesarean section were included in the study. Patients were given intravenous 10 units syntocinon alone intra-operatively from November 1 to December 31, 2010, while 0.25 mg ergometrine intramuscular was added to 10 units intravenous syntocinon from January 1 to February 28, 2011. Frequency of postpartum haemorrhage, adverse effects of drugs and maternal morbidity and mortality were assessed by using chi square test. P <0.05 was taken as statistically significant. Results: Of the total number of 701 subjects, 378 (54%) women were given 10 units syntocinon and 323 (46%) were given 0.25 mg ergometrine in addition to 10 units syntocinon. The mean age in the syntocinon group was 28+-3.5 yrs with gestational age of 37.5+-2 weeks, while that in syntocinon-ergometrine group was 29+-3.4 years and 38+-2 weeks respectively. Postpartum haemorrhage in the syntocinon group was found in 38 (10%) women versus 05 (1.5%) women) in the other group (p<0.001). Adverse effects like nausea, vomiting and raised blood pressure were slightly more with syntocinon-ergometrine than syntocinon alone (n=56; 15.3% vs n=35; 9.2%), but it was not statistically significant. Post partum haemorrhage was responsible for 40% of maternal mortality during the study period and that was in the syntocinon group. Conclusion: Prophylactic ergometrine in addition to syntocinon is superior to syntocinon alone in decreasing frequency of postpartum haemorrhage in caesarean section and associated maternal morbidity and mortality. Regarding safety profile, the two groups showed no statistically significant change. (author)

4

Current use of intraosseous infusion in Danish emergency departments: a cross-sectional study  

DEFF Research Database (Denmark)

Intraosseous infusion (IOI) is recommended when intravenous access cannot be readily established in both pediatric and adult resuscitation. We evaluated the current use of IOI in Danish emergency departments (EDs).

Molin, Rune; Hallas, Peter

2010-01-01

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A randomised controlled trial of oxytocin 5IU and placebo infusion versus oxytocin 5IU and 30IU infusion for the control of blood loss at elective caesarean section--pilot study. ISRCTN 40302163.  

LENUS (Irish Health Repository)

OBJECTIVE: To compare the blood loss at elective lower segment caesarean section with administration of oxytocin 5IU bolus versus oxytocin 5IU bolus and oxytocin 30IU infusion and to establish whether a large multi-centre trial is feasible. STUDY DESIGN: Women booked for an elective caesarean section were recruited to a pilot randomised controlled trial and randomised to either oxytocin 5IU bolus and placebo infusion or oxytocin 5IU bolus and oxytocin 30IU infusion. We wished to establish whether the study design was feasible and acceptable and to establish sample size estimates for a definitive multi-centre trial. The outcome measures were total estimated blood loss at caesarean section and in the immediate postpartum period and the need for an additional uterotonic agent. RESULTS: A total of 115 women were randomised and 110 were suitable for analysis (5 protocol violations). Despite strict exclusion criteria 84% of the target population were considered eligible for study participation and of those approached only 15% declined to participate and 11% delivered prior to the planned date. The total mean estimated blood loss was lower in the oxytocin infusion arm compared to placebo (567 ml versus 624 ml) and fewer women had a major haemorrhage (>1000 ml, 14% versus 17%) or required an additional uterotonic agent (5% versus 11%). A sample size of 1500 in each arm would be required to demonstrate a 3% absolute reduction in major haemorrhage (from baseline 10%) with >80% power. CONCLUSION: An additional oxytocin infusion at elective caesarean section may reduce blood loss and warrants evaluation in a large multi-centre trial.

Murphy, Deirdre J

2012-02-01

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Current use of intraosseous infusion in Danish emergency departments: a cross-sectional study  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Intraosseous infusion (IOI is recommended when intravenous access cannot be readily established in both pediatric and adult resuscitation. We evaluated the current use of IOI in Danish emergency departments (EDs. Methods An online questionnaire was e-mailed to the Heads of Department of the twenty EDs currently established in Denmark. The questionnaire focused on the use of IOI in the EDs and included questions on frequency of use, training, equipment and attitudes towards IOI. Results We received a total of 19 responses (response rate of 95%. Of the responding 19 Danish EDs 74% (n = 14 reported having intraosseous devices available. The median number of IOI procedures performed in these departments over the preceding 12 months was 5.0 (range: 0-45. In 47% (n = 9 of the departments, prior training sessions in the use of intraosseous devices had not been provided, and 42% (n = 8 did not have local guidelines on IOI. The indication for IOI use was often not clearly defined and only 11% (n = 2 consistently used IOI on relevant indication. This is surprising as 95% (n = 18 of responders were aware that IOI can be utilized in both pediatric and adult resuscitation. Conclusions The study shows considerable variations in IOI usage in Danish EDs despite the fact that IOI devices were available in the majority of EDs. In addition, in many EDs there were no local guidelines on IOI and no training in the procedure. We recommend more extensive training of medical staff in IOI techniques in Danish EDs.

Brabrand Mikkel

2010-07-01

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Oxytocin bolus versus oxytocin bolus and infusion for control of blood loss at elective caesarean section: double blind, placebo controlled, randomised trial.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

OBJECTIVES: To determine the effects of adding an oxytocin infusion to bolus oxytocin on blood loss at elective caesarean section. DESIGN: Double blind, placebo controlled, randomised trial, conducted from February 2008 to June 2010. SETTING: Five maternity hospitals in the Republic of Ireland. PARTICIPANTS: 2069 women booked for elective caesarean section at term with a singleton pregnancy. We excluded women with placenta praevia, thrombocytopenia, coagulopathies, previo...

Gleeson, Ronan Patrick; Murphy, Deirdre

2011-01-01

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21 CFR 526.88 - Amoxicillin trihydrate for intramammary infusion.  

Science.gov (United States)

...false Amoxicillin trihydrate for intramammary infusion. 526.88 Section 526...DRUGS, FEEDS, AND RELATED PRODUCTS INTRAMAMMARY DOSAGE FORMS § 526.88 Amoxicillin trihydrate for intramammary infusion. (a)...

2010-04-01

9

21 CFR 526.1130 - Hetacillin potassium for intramammary infusion.  

Science.gov (United States)

... false Hetacillin potassium for intramammary infusion. 526.1130 Section...DRUGS, FEEDS, AND RELATED PRODUCTS INTRAMAMMARY DOSAGE FORMS § 526.1130 Hetacillin potassium for intramammary infusion. (a)...

2010-04-01

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21 CFR 870.1800 - Withdrawal-infusion pump.  

Science.gov (United States)

...2010-04-01 false Withdrawal-infusion pump. 870.1800 Section 870.1800 Food...Devices § 870.1800 Withdrawal-infusion pump. (a) Identification. A withdrawal-infusion pump is a device designed to inject...

2010-04-01

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21 CFR 880.5725 - Infusion pump.  

Science.gov (United States)

...2010-04-01 2010-04-01 false Infusion pump. 880.5725 Section 880.5725 Food and...Therapeutic Devices § 880.5725 Infusion pump. (a) Identification. An infusion pump is a device used in a health care facility...

2010-04-01

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21 CFR 880.5725 - Infusion pump.  

Science.gov (United States)

...2010-04-01 2010-04-01 false Infusion pump. 880.5725 Section 880.5725 Food...Use Therapeutic Devices § 880.5725 Infusion pump. (a) Identification. An infusion pump is a device used in a health care...

2010-04-01

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Hypoglycaemia secondary to labetalol infusion.  

Science.gov (United States)

A 42-year-old multigravida with severe pre-eclampsia had an emergency caesarean section under spinal anaesthesia. Peri-operatively, her arterial pressure was controlled with oral methyldopa and an intravenous infusion of labetalol. Postoperatively, in the Intensive Care Unit, she had recurrent episodes of hypoglycaemia which required treatment with intravenous glucose. These episodes resolved when the labetalol infusion was stopped. Clinicians should be aware of the potential of labetalol to cause hypoglycaemia. PMID:21575539

Immanni, Sudhir; Khan, Ehtesham Izhar; Staunton, Michael

2011-05-01

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Infusion therapy.  

Science.gov (United States)

Strides made in the past several decades have greatly enhanced patients' quality of life particularly that of cancer patients, who often have to receive continuous infusion therapy. Research efforts that resulted in the development and use of the long-line central indwelling silicone elastomeric catheter, new methods for problem management, and the design and use of portable infusion pumps for administration of investigational and other chemotherapeutic agents have made it possible to deliver safe care to these patients on an ambulatory basis. These new programs made it imperative that patients who received such care would have audio, not just verbal and written information to assist them in carrying out procedures for these programs. Patient education programs, and particularly the ones at M. D. Anderson Cancer Center have produced many teaching and information aids. These programs are a credit to the pioneering spirit and trust of patients who came to M. D. Anderson in those early days. I can remember well when all of us were trying and working together on these programs. This spirit continues today. PMID:1823571

Hilkemeyer, R E

1991-01-01

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Induction of labor using double balloon cervical device in women with previous cesarean section: Experience and review  

Directory of Open Access Journals (Sweden)

Full Text Available Induction of labour remains one of the most challenging interventions in current obstetrics. Different pharmaceuticals have been used for cervical ripening such as prostaglandins; however they can lead to a number of potential inconvenient risks namely uterine tachysystole and pathological fetal cardiotocography (CTG. In cases of women with previous caesarean births, using prostaglandins would pose even higher risks such as uterine rupture and perinatal mortality. A mechanical method of cervical ripening could represent an alternative for these women. We report the use of the extra-amniotic double balloon cervical device (Cook’s device for ripening of unfavourable cervix in seventeen women attempting vaginal birth after cesarean section (VBAC. Using Bishop scoring system to assess cervical dilatetion, position, consistency, fetal station and effacement, the unfavourable cervix is the cervix that scores less than 6. We review the relevant literature discussing this method of induction focusing on its effectiveness, simplicity, safety and efficacy, low cost and any associated serious side effects. Conclusion: Success was estimated to be over 50% with no serious life threatening maternal or fetal complications. We considered the process satisfactory and practical. We recommend larger studies to assess safety and efficacy of Cook’s device in vaginal birth after caesarean section before embarking on routine elective caesarean delivery. Objectives: To estimate success rate for vaginal delivery after previous caesarean section using cervical double balloon device (Cook’s device. Design: Three-year observational study. Setting: Maternity unit in district general hospital, UK. Population: Women who had one previous lower segment caesarean section and unfavourable cervix identified as having Bishop Score less than 6. Methods: Data were obtained from the birth registry over 3 years from January 2008 until December 2010. Main outcome: Measure successful vaginal delivery. Results: Out of 25 cases that had induction of labour with history of one previous lower segment caesarean section, 17 patients did fit in the inclusion criteria and were studied. 53% had a successful vaginal delivery while 47% had to have cesarean section either due to failure to progress or pathological cardiotocography. 82% required to have syntocinon infusion for augmentation as per local unit protocol. All newborn babies were in good condition and did not require admission to neonatal intensive care unit.

N. Nassif

2013-03-01

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Continuous-infusion adriamycin  

International Nuclear Information System (INIS)

This chapter discusses the diminished cardiotoxicity as well as diminished nausea and vomiting with continuous infusions of adriamycin to patients undergoing radiation therapy, particularly with infusions of 48 hours or longer, and best with 96-hour infusions, the longest duration that has been studied systematically. In breast cancer, data show that more adriamycin is better, but only for a selected subgroup of patients: those with complete remission. The diminished cardiotoxicity makes the use of adriamycin more attractive in the adjuvant situation, where increased safety will decrease the chances of long-term complications and make retreatment easy for cured patients who develop second malignancies

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21 CFR 526.1696d - Penicillin G procaine-novobiocin for intramammary infusion.  

Science.gov (United States)

...Penicillin G procaine-novobiocin for intramammary infusion. 526.1696d Section...FEEDS, AND RELATED PRODUCTS INTRAMAMMARY DOSAGE FORMS § 526.1696d...Penicillin G procaine-novobiocin for intramammary infusion. (a)...

2010-04-01

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Infusion-embolization.  

Science.gov (United States)

Transcatheter intra-arterial therapy for the cancer patient encompasses infusion of chemotherapy and embolization. Intra-arterial infusion of chemotherapeutic agents has been resurrected because of the availability of new drugs, combinations of drugs, and the capability of percutaneous selective catheter placement. Intra-arterial infusion has been effective in patients with carcinomas of the liver, bladder, prostate, uterus, ovary, and lung and in bone and soft tissue sarcomas, melanomas, and tumors of the brain. Embolization of the arterial supply, creating ischemia of the neoplasm, has been employed in the therapeutic management of patients with primary and secondary neoplasms of the liver, kidney, and bone. The median survival of 100 patients with neoplasms of the liver from the time of hepatic artery embolization was 11.5 months. In 100 patients with pulmonary metastases from carcinoma of the kidney, 28 experienced a response to renal artery embolization, a therapeutic delay of 4 to 7 days, nephrectomy, and Depo-Provera (medroxyprogesterone). Seven of 12 patients with giant cell tumor of the pelvis and lumbar spine responded to arterial embolization after all other therapy failed. Chemoembolization, the combination of arterial infusion of chemotherapy and embolization, can be accomplished by the use of microencapsulated agents, liposomes, and particulate emboli with drugs. This approach integrates the advantages of infusion and occlusion, and has considerable potential. Intra-arterial immunotherapy has been initiated with bacillus Calmette-Guerin (BCG) administration into renal neoplasms in patients with metastatic disease. PMID:6093984

Wallace, S; Charnsangavej, C; Carrasco, C H; Bechtel, W

1984-12-01

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Continuous radioisotope infusion  

International Nuclear Information System (INIS)

Continuous infusion of a radioactive marker was used instead of a conventional bolus injection to improve haemodynamic studies. Tc-99m was infused into the blood circulation at a constant rate for 100-300 seconds and the activity in the target structure was measured by a gamma camera with a computer system or by a single detector. The concentration of the marker increased linearly at the same rate throughout the circulating system. Due to variations in transport time from infusion site to different parts of the system the rise of activity occurred at different times. A theory for the calculations was presented and consequently confirmed in a model study. Blood flow patterns in artificial kidneys and alterations in renal blood flow induced by angiotensin were studied. The results are presented as time-function curves or as computer images. This technique can be used to evaluate distributions and alterations of flow in separate parts of a complex circulating system. (author)

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Changes in Basal Insulin Infusion Rates With Subcutaneous Insulin Infusion  

Science.gov (United States)

OBJECTIVE Evaluation of the time required until a change in the basal insulin infusion rate with an insulin pump induces subsequent changes in the metabolic effect. RESEARCH DESIGN AND METHODS In this euglycemic glucose clamp study, 10 male subjects with type 1 diabetes received three different subcutaneous insulin infusion rates (0.5, 1.0, and 2.0 units/h; for 4 h each) of insulin lispro (IL) with insulin pumps. RESULTS An increase in insulinemia occurred within 15–30 min after changing the infusion rate. While the serum IL levels reached a steady state at the end of the infusion period, the glucose infusion rates did not always reach steady-state levels with the higher infusion rates. However, an increase in the glucose consumption occurred within 30–60 min after switching the infusion rate. CONCLUSIONS Several hours are required until a new steady state in the metabolic effect is achieved after a significant change in basal insulin infusion. PMID:19487635

Heinemann, Lutz; Nosek, Leszek; Kapitza, Christoph; Schweitzer, Matthias-Axel; Krinelke, Lars

2009-01-01

 
 
 
 
21

[Development of smart infusion system].  

Science.gov (United States)

The free care smart infusion system which has the function of liquid end alarm and automatic stopping has been designed. In addition, the system can send the alarm to the health care staff by Zigbee wireless network. Besides, the database of infusion information has been set up, it can be used for inquiry afterwards. PMID:24839846

Li, Junyang

2014-01-01

22

Breadboard development of a fluid infusion system  

Science.gov (United States)

A functional breadboard of a zero gravity Intravenous Infusion System (IVI) is presented. Major components described are: (1) infusate pack pressurizers; (2) pump module; (3) infusion set; and (4) electronic control package. The IVI breadboard was designed to demonstrate the feasibility of using the parallel solenoid pump and spring powered infusate source pressurizers for the emergency infusion of various liquids in a zero gravity environment. The IVI was tested for flow rate and sensitivity to back pressure at the needle. Results are presented.

Thompson, R. W.

1974-01-01

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The use of a volumetric infusion pump for the intra-arterial infusion of drugs.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Volumetric infusion pumps are widely used for intravenous infusions. We have extended their use to the intra-arterial infusion of drugs. An in vitro evaluation of the performance of such devices, under experimental conditions comparable to an intra-arterial infusion, was carried out. The results obtained confirmed the accuracy of volumetric infusion pumps for intra-arterial infusions. The system was found to be safe, reliable and simple in clinical practice.

Cooper, A. M.; Lilliman, M.

1985-01-01

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Abandonment of infusion in production workings in the Ruhr coalfield; Traenkverzicht in Gewinnungsbetrieben im Ruhrkarbon  

Energy Technology Data Exchange (ETDEWEB)

Infusion of coal before extraction is a measure to reduce dust both from the point of view of health protection as well as fire and explosion protection. However, the effectiveness of infusion is higher in highly coalified sections of seams than in sections with low coalification. The highly effective dust suppression measures in the area of coal winning by cutting and stripping have meanwhile allowed the infusion effect to recede into the background, so that it is possible to dispense with this measure in seam areas with low coalification. It was proved in practical tests that the effectiveness of the infusion is no longer detectable, if optimised secondary dust suppression methods are used. Nowadays infusion work can be dispensed with in stratigraphically young seams during coal winning, if it is guaranteed that mining authority requirements to ensure lower dust pollution are met. (orig.)

Kadow, T.; Suedhofer, F. [Deutsche Steinkohle AG, Herne (Germany); Henke, B.

2004-03-18

25

Infusing Culture in Career Counseling  

Science.gov (United States)

This article introduces the culture-infused career counselling (CICC) model. Six principles are foundational to a tripartite model emphasizing cultural self-awareness, awareness of client cultural identities, and development of a culturally sensitive working alliance. The core competencies ensure the cultural validity and relevance of career…

Arthur, Nancy; Collins, Sandra

2011-01-01

26

Remifentanil infusion prolongs spinal anesthesia.  

Science.gov (United States)

Spinal anesthesia was given to a patient undergoing transurethral resection ofprostate (TURP). A total of 3.2 ml of bupivacaine 0.5% mixed with fentanyl 20 mcg were used. The patient started experiencing sensation after 150 min. Remifentanil intravenous infusion prolonged the duration of anesthesia for an additional 105 minutes. PMID:23833858

Soliman, Mohamed Hassan; Ibrahim, Sami M; Saeed, Kiran; El-Omrani, Hani; Kokach, Ousama

2013-02-01

27

Intravenous insulin infusion in diabetic emergencies.  

Science.gov (United States)

Continuous intravenous insulin and dextrose infusions were used in managing various diabetic emergencies. Standard and constant rates of insulin and dextrose infusion resulted in satisfactory control of blood glucose concentrations during labour, after major surgery, and in patients recovering from ketoacidosis (average insulin infusion rates 1, 2, and 3 U/h respectively). Higher infusion rates were used to correct or prevent ketoacidosis in pregnant diabetic women who had received steroids and sympathomimetic agents. The infusion method is simple, reliable, and flexible, and may help to simplify management of diverse types of diabetic emergencies. PMID:102400

Leslie, R D; Mackay, J D

1978-11-11

28

What is Nano-Infusion?  

Science.gov (United States)

This page from Nano-Link describes Nano-Infusion. This program "promotes integration and inclusion of nanoscale concepts into high school and college level education." Teachers are encouraged to join the free program to obtain training, support, and nano-related supplies that will aid in introducing nano experiments into their classrooms. To join the program, applicants merely need to create an account on the Nan-Link website and complete and introductory survey.

2012-11-08

29

Scleritis complicating zoledronic acid infusion.  

Science.gov (United States)

We present a case of severe unilateral posterior scleritis associated with zoledronic acid administration that was recognized and treated in a timely manner. Subsequent use of pamidronate was associated with milder inflammation in the same eye that eventually resolved with continued monthly infusions, indicating the possibility of immunologic tolerance. Physicians prescribing these drugs should be aware of this side effect, which, if not recognized and treated appropriately, is potentially devastating. We review the published data as well as the current treatment recommendations. PMID:17026827

Benderson, David; Karakunnel, Joyson; Kathuria, Sajeev; Badros, Ashraf

2006-09-01

30

Continuous infusion with implantable pumps  

International Nuclear Information System (INIS)

This paper discusses a battery-powered, telemetry, programmable pump connected to a silicon catheter placed percutaneously through the subclavian or internal jugular vein that has been used to administer prolonged infusion of cytotoxic agents. The authors analyzed technique, system performance, and results for 246 consecutive systemic implants. The implantation procedures were performed entirely by the interventional radiology staff, and the encountered complications were diagnosed and controlled by using conventional radiography, digital subtraction angiography, and CT. It was concluded that management of totally implantable devices requires skilled organization and ready availability of radiologic equipment

31

Thrombolytic treatment for acute ischemic cerebral stroke: intraarterial urokinase infusion vs. intravenous heparin and urokinase infusion  

International Nuclear Information System (INIS)

To evaluate the efficacy and limitation of intra-arterial urokinase (IAUK) infusion for treatment of acute cerebral stroke. Twenty-seven acute cerebral stroke patients treated with IAUK infusion within six hours of stroke onset were reviewed. All patients showed normal initial brain findings on CT. In 21 patients, urokinase(5-15 x 105IU) was administered through a microcatheter placed into or proximal to occluded segment. Mechanical disruption of thrombus by guidewire was performed in 17 patients. Angiographic and clinical responses and complications after IAUK infusion, were evaluated and the results were compared with those of intravenous heparin(N=19) and urokinase infusion(N=19). Complete or partial angiographic recanalization of occluded segment was found in 18 patients (67%), and neurologic improvement was followed in 14 patients(52%). The degree of improvement on the stroke scale score after IAUK infusion was statistically more significant(p<0.05) than that shown after intravenous heparin and urokinase infusion. Complications after IAUK infusion were large(15%) and small amount intracerebral hemorrhage(15%), contrast leakage into brain parenchyma(11%), and gastrointestinal bleeding(4%). Between the IAVK and the intravenous urokinase infusion group, differences in extent and types of complications were statistically insignificant, but were significantly higher in those two groups than in the intravenous heparin infusion group. IAUK infusion may be effn infusion group. IAUK infusion may be effective for the treatment of acute cerebral stroke

32

Infusing Systems Thinking into Career Counseling  

Science.gov (United States)

This study examined the role of career counselors in infusing systems thinking into occupational advising. The authors conducted a qualitative review and analysis of selected literature on systems thinking and analyzed trends for adaptation to career counseling practice. This analysis suggests that career counselors need to infuse systems…

Ryan, Charles W.; Tomlin, James H.

2010-01-01

33

Comparison of the locomotor-activating effects of bicuculline infusions into the preoptic area and ventral pallidum.  

Science.gov (United States)

Ambulatory locomotion in the rodent is robustly activated by unilateral infusions into the basal forebrain of type A gamma-aminobutyric acid receptor antagonists, such as bicuculline and picrotoxin. The present study was carried out to better localize the neuroanatomical substrate(s) underlying this effect. To accomplish this, differences in total locomotion accumulated during a 20-min test period following bicuculline versus saline infusions in male Sprague-Dawley rats were calculated, rank ordered and mapped on a diagram of basal forebrain transposed from immunoprocessed sections. The most robust locomotor activation was elicited by bicuculline infusions clustered in rostral parts of the preoptic area. Unilateral infusions of bicuculline into the ventral pallidum produced an unanticipatedly diminutive activation of locomotion, which led us to evaluate bilateral ventral pallidal infusions, and these also produced only a small activation of locomotion, and, interestingly, a non-significant trend toward suppression of rearing. Subjects with bicuculline infused bilaterally into the ventral pallidum also exhibited persistent bouts of abnormal movements. Bicuculline infused unilaterally into other forebrain structures, including the bed nucleus of stria terminalis, caudate-putamen, globus pallidus, sublenticular extended amygdala and sublenticular substantia innominata, did not produce significant locomotor activation. Our data identify the rostral preoptic area as the main substrate for the locomotor-activating effects of basal forebrain bicuculline infusions. In contrast, slight activation of locomotion and no effect on rearing accompanied unilateral and bilateral ventral pallidal infusions. Implications of these findings for forebrain processing of reward are discussed. PMID:23423460

Zahm, Daniel S; Schwartz, Zachary M; Lavezzi, Heather N; Yetnikoff, Leora; Parsley, Kenneth P

2014-03-01

34

Strontium-rubidium infusion pump with in-line dosimetry  

International Nuclear Information System (INIS)

A strontium-rubidium infusion system is described which consists of: (a) means for generating rubidium 82 in a solution which can be infused into a patient; (b) means for infusing the solution into a patient; (c) means for measuring the radioactivity present in the solution as it is infused into the patient; and (d) means for controlling the means for infusing in response to the amount of radioactivity which has been infused into the patient

35

Pharmacokinetics and toxicology of continuously infused nitroimidazoles  

International Nuclear Information System (INIS)

The pharmacokinetics and toxicology of misonidazole (MISO) and SR-2508 given by continuous intraperitoneal infusion were studied in female C3H mice. The survival (time to death) of animals receiving continuous infusions of SR-2508 and MISO was compared and related to plasma concentration, rate of infusion and total amount of drug delivered. Brain and plasma concentrations were determined by HPLC. For SR-2508, plasma concentration was directly proportional to the infusion rate. However, as the infusion rate of MISO was doubled, the plasma concentration of MISO increased approximately 6-fold, reflecting a substantial increase in the apparent half-life. The brain/plasma concentration ratio in animals infused for up to 6 days with SR-2508 remained constant, at approximately 0.09. At plasma concentrations of 0.08-1.5 mM, animals receiving SR-2508 survived approximately 3 times as long as animals exposed to a comparable plasma concentration of MISO. Even at the lowest infusion rates employed in this study, the survival of mice receiving SR-2508 was much shorter than would have been predicted if the toxicity of these two drugs were solely related to the integral brain exposure. The low brain/plasma concentration ratio of SR-2508 was maintained throughout long continuous exposures

36

Antiproliferative activities of tea and herbal infusions.  

Science.gov (United States)

The consumption of tea and herbal infusions has increased rapidly in recent years. More and more people consume these infusions as daily beverages as well as for health purposes. The aim of this study was to supply new information on the antiproliferative function of these infusions for nutritionists and the general public. The in vitro antiproliferative activities of 60 different tea and herbal infusions on four cancer cell lines were evaluated by MTT assay. The results showed that some infusions strongly inhibited the proliferation of A549 (human lung cancer cells), MCF-7 (human breast cancer cells), HepG2 (human hepatoma cells) and HT-29 (human colon cancer cells), and decreased the viability of these cancer cell lines in a dose-dependent manner. In addition, some bioactive components in the infusions were also separated and determined by HPLC. The results suggested that some tea and herbal infusions may be potential dietary supplements for the prevention and treatment of cancer. PMID:23307138

Li, Fang; Li, Sha; Li, Hua-Bin; Deng, Gui-Fang; Ling, Wen-Hua; Xu, Xiang-Rong

2013-04-25

37

Krypton 81m infusion studies. Chapter 18  

International Nuclear Information System (INIS)

A technique is described to give a continuous, constant-rate, intravascular infusion of 81Krsup(m). Modifications of earlier generators included production of sodium-free 81Rb, the use of a solution of commercial sterile isotonic non-ionic 5% dextrose-in-water as an eluant, the incorporation of a constant-rate infusion pump, and the miniaturization of the generator column and catheter system. Results are presented of studies of 81Krsup(m) distribution in dogs, using both intravenous and intra-arterial infusion. (author)

38

A new infusion pathway intactness monitoring system.  

Science.gov (United States)

A new infusion pathway monitoring system has been developed for hospital and home use. The system consists of linear integrated circuits and a low-power 8-bit single chip microcomputer which constantly monitors the infusion pathway intactness. An AC (alternating current) voltage is induced on the patient's body by electrostatic coupling from the normal 100 volt, 60 Hz AC power line wiring field in the patient's room. The induced AC voltage can be recorded by a main electrode wrapped around the infusion polyvinyl chloride tube. A reference electrode is wrapped on the electrode to monitor the AC voltage around the main electrode. If the injection needle or infusion tube becomes detached, then the system detects changes in the induced AC voltages and alerts the nursing station, via the nurse call system or PHS (personal handy phone system). PMID:17945872

Ogawa, Hidekuni; Yonezawa, Yoshiharu; Maki, Hiromichi; Ninomiya, Ishio; Sata, Koji; Hamada, Shingo; Caldwell, W Morton

2006-01-01

39

Social and Personal Factors in Semantic Infusion Projects  

Science.gov (United States)

As part of our semantic data framework activities across multiple, diverse disciplines we required the involvement of domain scientists, computer scientists, software engineers, data managers, and often, social scientists. This involvement from a cross-section of disciplines turns out to be a social exercise as much as it is a technical and methodical activity. Each member of the team is used to different modes of working, expectations, vocabularies, levels of participation, and incentive and reward systems. We will examine how both roles and personal responsibilities play in the development of semantic infusion projects, and how an iterative development cycle can contribute to the successful completion of such a project.

West, P.; Fox, P. A.; McGuinness, D. L.

2009-12-01

40

Immunoglobulin replacement treatment by rapid subcutaneous infusion  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Long term intravenous immunoglobulin (IVIG) infusion is an effective treatment for children with immunodeficiencies, but can be complicated by poor venous access, systemic adverse reactions, and the need for frequent hospital admission. Rapid subcutaneous immunoglobulin (SCIG) infusion has been found to be effective in adults with primary immunodeficiency. Twenty six children were treated with SCIG for a median period of two years (range six months to 3.5 years). Fifteen ...

Gaspar, J.; Gerritsen, B.; Jones, A.

1998-01-01

 
 
 
 
41

Polysaccharide composition of Fraxinus angustifolia Leave infusions  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The use of plant infusions with medicinal purposes, such as the ones from members of the Fraxinus genus, is an ancient practice that has been reported by popular medicine [1]. The health benefits are associated with the presence of phenolic compounds and polysaccharides, among others [2]. Although phenolic compounds have been studied in detail for more than two decades, the characterization of the polysaccharides present in plant infusions and their involvement in the health benefits is still...

Martins, Vitor Manuel Ramalheira; Coimbra, Manuel A.

2010-01-01

42

Stability and Antibacterial Activity of Cefepime during Continuous Infusion  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The stability of cefepime during simulated continuous infusion was determined with a motorized portable infusion pump worn over a period of 24 to 36 h. Susceptibility testing on cefepime solutions over time indicates that the degradation products do not exhibit antibacterial activity. Cefepime stability at 24 h following continuous infusion was 94.3% ± 1.0%, which supports the use of continuous infusion.

Sprauten, Pa?l F.; Beringer, Paul M.; Louie, Stan G.; Synold, Timothy W.; Gill, Mark A.

2003-01-01

43

Subcutaneous insulin infusion: change in basal infusion rate has no immediate effect on insulin absorption rate  

International Nuclear Information System (INIS)

Eight insulin-dependent diabetic patients were simultaneously given subcutaneous infusions (1.12 IU/h each) of 125I-labeled Actrapid insulin in each side of the abdominal wall. After 24 h of infusion, the size of the infused insulin depots was measured by external counting for 5 h. The basal infusion rate was then doubled in one side and halved in the other for the next 4 h. Finally, 1.12 IU/h of insulin was given in both sides of the abdominal wall for an additional 3 h. The changes in the size of the depots were measured, and the absorption rates for each hour were calculated. During the first 5 h of infusion, the depot size was almost constant (approximately 5 IU) with an absorption rate that equaled the infusion rate. Doubling the infusion rate led to a significant increase in depot size, but the absorption rate remained unchanged for the first 3 h, and only thereafter was a significant increase seen. When the infusion rate was reduced to the initial 1.12 IU/h, the absorption rate remained elevated during the next 3 h. Correspondingly, when the infusion rate was decreased, the depot size also decreased, but the absorption rate remained unchanged for the first 3 h. The results show that a change in the basal insulin infusion rate does not lead to any immediate change in the insulin absorption rate. This should be considered when planning an insulin-infusion program that includes alteration(s) in the basal-rate settingtting

44

Accelerated infliximab infusions for inflammatory bowel disease improve effectiveness  

Digital Repository Infrastructure Vision for European Research (DRIVER)

AIM: To study the safety and effectiveness associated with accelerated infliximab infusion protocols in patients with inflammatory bowel disease (IBD). METHODS: Original protocols and infusion rates were developed for the administration of infliximab over 90-min and 60-min. Then the IBD patients on stable maintenance infliximab therapy were offered accelerated infusions. To be eligible for the study, patients needed a minimum of four prior infusions. An initial infusion of 90-min was given to...

2012-01-01

45

Intragastric infusion of nutrients in cattle.  

Science.gov (United States)

1. A method of continuous alimentation of cattle by total infusion of nutrients has been developed. Friesian steers within the weight range 100-400 kg live weight and dairy cows were used. 2. A multi-channel peristaltic pump was used to infuse solutions of volatile fatty acids (VFA), minerals, and buffer through a cannula in the rumen and a casein-vitamin solution into the abomasum. 3. The method described was successfully used with two cows and four steers in a series of trials over intervals of approximately 2 months. The levels of infusion were up to twice maintenance and with various relative proportions of VFA and protein. Blood metabolite levels, rumen osmotic pressure and pH were monitored and effectively controlled. PMID:6805503

MacLeod, N A; Corrigall, W; Stirton, R A; Orskov, E R

1982-05-01

46

A new venous infusion pathway monitoring system.  

Science.gov (United States)

A new infusion catheter pathway monitoring system employing linear integrated circuits and a low-power 8-bit single chip microcomputer has been developed for hospital and home use. The sensor consists of coaxial three-layer conductive tapes wrapped around the polyvinyl chloride infusion tube. The inner tape is the main electrode, which records an AC (alternating current) voltage induced on the patient's body by electrostatic coupling from the normal 100 volt, 60 Hz AC power line wiring field in the patient's room. The outside tape layer is a reference electrode to monitor the AC voltage around the main electrode. The center tape layer is connected to system ground and functions as a shield. The microcomputer calculates the ratio of the induced AC voltages recorded by the main and reference electrodes and if the ratio indicates a detached infusion, alerts the nursing station, via the nurse call system or low transmitting power mobile phone. PMID:18002453

Maki, Hiromichi; Yonezawa, Yoshiharu; Ogawa, Hidekuni; Ninomiya, Ishio; Sata, Koji; Hamada, Shingo; Caldwell, W Morton

2007-01-01

47

Rapid Self-infusion of Tap Water  

Directory of Open Access Journals (Sweden)

Full Text Available Intravenous self-infusion of tap water has never been reported in the literature.  We present a 24-year-old healthy man who self-administered 2.5 L of tap water over 2 hours and developed acute illness including fever, change of mental status, acute hemolysis, low-grade disseminated intravascular coagulation, and acute kidney injury.  

Sanjay Chaudhary

2013-03-01

48

Rapid Self-infusion of Tap Water  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Intravenous self-infusion of tap water has never been reported in the literature.  We present a 24-year-old healthy man who self-administered 2.5 L of tap water over 2 hours and developed acute illness including fever, change of mental status, acute hemolysis, low-grade disseminated intravascular coagulation, and acute kidney injury.  

Sanjay Chaudhary; Kianoush Kashani; Williams, Amy W.; El-zoghby, Ziad M.; Albright, Robert C.; Qi Qian

2013-01-01

49

Intermittent intraarterial infusion chemotherapy for intrapelvic malignancy  

International Nuclear Information System (INIS)

A new modality of topical chemotherapy using intermittent arterial infusion with simultanous occlusion of contralateral feeding artery was performed in 6 patients with intrapelvic malignant tumors (4 prostatic cancer, 1 ovarian cancer and 1 vaginal cancer). The alteration of intrapelvic hemodynamics was achieved by steel coil embolization in the contralateral internal iliac artery via an indwelling infusion tube. After coil embolization, pelvic angiography demonstrated distinct tumor vessels which were not visible before embolization. Furthermore, intensive RI accumulation was found at the site of tumor by scintigram with 99mTc-MAA injected through the infusion tube. In all 4 patients with prostatic cancer, remarkable improvements in symptoms were noted. In two of these patients, a remarkable reduction in tumor size was revealed by Computed Tomogram and sonogram. In the patient with ovarian cancer, tumor size was reduced without pancytopenia which frequently accompanies conventional systemic chemotherapy. These results indicated that this therapy was extremely valuable in the management of intrapelvic malignant tumors, as it allowed concentrated anticancer agents to be selectively infused directly into the tumor feeding vessels without serious side effects. (author)

50

Infusing Functional Law into the Classroom.  

Science.gov (United States)

The court system touches the lives of many children in the school system, some through divorce, and others through their own illegal behavior. Principals and administrators need to infuse a functional knowledge of the legal system so that these children will be better able to cope and deal with life events that cause them to be placed in contact…

Frieman, Barry B.; Fine, Bobbie

51

21 CFR 526.88 - Amoxicillin trihydrate for intramammary infusion.  

Science.gov (United States)

...2010-04-01 false Amoxicillin trihydrate for intramammary infusion...DOSAGE FORMS § 526.88 Amoxicillin trihydrate for intramammary infusion...single dose syringe contains amoxicillin trihydrate equivalent to 62.5...

2010-04-01

52

Centrally infused bradykinin increases baroreceptor reflex sensitivity.  

Science.gov (United States)

Kinins are present in the central nervous system, and central administration of bradykinin increases blood pressure and heart rate. In this study, we determined the effect of intracerebroventricular infusion of bradykinin on the baroreceptor reflex of conscious rats. Male Wistar rats were anesthetized with thiobarbital (40 mg/kg i.p.), and chronic intracerebroventricular cannulas (25 gauge) were implanted into the lateral ventricles. Baroreceptor control of heart rate was evaluated by recording reflex heart rate changes (beats per minute) in response to mean arterial pressure changes (mm Hg) produced by bolus injection of phenylephrine (0.5-20 micrograms/kg i.v.) or sodium nitroprusside (0.5-25 micrograms/kg i.v.). The ratio beats per minute/mm Hg or the mean slope of the individual regression lines of the relation between heart rate and mean arterial pressure changes for increases or decreases in arterial pressure was used as an index of baroreceptor reflex sensitivity. Baroreceptor control of heart rate was evaluated within 1 and 3 hours of intracerebroventricular infusion of bradykinin (7.5 micrograms/7 microliters/hr) or saline (7 microliters/hr). There was no change in basal mean arterial pressure or heart rate during central bradykinin infusion (112 +/- 2 mm Hg and 402 +/- 18 beats per minute in the control period). After 1 hour of central bradykinin infusion, there was a significant increase of baroreceptor reflex sensitivity for increments in mean arterial pressure (-2.91 +/- 0.26 versus -1.5 +/- 0.24 beats per minute/mm Hg in the control period; p less than 0.01, paired Student's t test). In contrast, no significant changes were observed for the reflex tachycardia. Similar results were obtained with 3 hours of infusion.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:1735575

Gerken, V M; Santos, R A

1992-02-01

53

Intravenous infusions in chronic pain management.  

Science.gov (United States)

In the United States, millions of Americans are affected by chronic pain, which adds heavily to national rates of morbidity, mortality, and disability, with an ever-increasing prevalence. According to a 2011 report titled Relieving Pain in America: A Blueprint for Transforming Prevention, Care, Education, and Research by the Institute of Medicine of the National Academies, pain not only exacts its toll on people's lives but also on the economy with an estimated annual economic cost of at least $560 - 635 billion in health care costs and the cost of lost productivity attributed to chronic pain. Intravenous infusions of certain pharmacologic agents have been known to provide substantial pain relief in patients with various chronic painful conditions. Some of these infusions are better, and although not necessarily the first therapeutic choice, have been widely used and extensively studied. The others show promise, however are in need of further investigations. This article will focus on non-opiate intravenous infusions that have been utilized for chronic painful disorders such as fibromyalgia, neuropathic pain, phantom limb pain, post-herpetic neuralgia, complex regional pain syndromes (CRPS), diabetic neuropathy, and central pain related to stroke or spinal cord injuries. The management of patients with chronic pain conditions is challenging and continues to evolve as new treatment modalities are explored and tested. The following intravenous infusions used to treat the aforementioned chronic pain conditions will be reviewed: lidocaine, ketamine, phentolamine, dexmedetomidine, and bisphosphonates. This overview is intended to familiarize the practitioner with the variety of infusions for patients with chronic pain. It will not, however, be able to provide guidelines for their use due to the lack of sufficient evidence. PMID:23703410

Kosharskyy, Boleslav; Almonte, Wilson; Shaparin, Naum; Pappagallo, Marco; Smith, Howard

2013-01-01

54

Pharmacokinetics of continuous subcutaneous insulin infusion  

DEFF Research Database (Denmark)

One of the reasons for the variability of blood glucose regulation in Type 1 (insulin-dependent) diabetic patients is the huge variation in subcutaneous absorption of intermediate-acting insulin. We have investigated the variation in insulin absorption during continuous subcutaneous insulin infusion in eight such patients. The content of insulin in the subcutaneous tissue was measured using 125I-labelled insulin. The concentration of free serum insulin and blood glucose was followed from 1 h before and from 7 h after breakfast on two consecutive days. The amount of insulin absorbed during 24 h differed in all cases by less than 3% from the daily insulin dose given by the pumps. Mean insulin absorption rates and mean free insulin concentration showed peak values 30-90 min after meal bolus injections; this was sufficient to maintain near-normal blood glucose. Mean free serum insulin correlated strongly with disappearance of insulin from the subcutaneous tissue (r = 0.98). From the insulin absorption rates and free insulin concentrations during basal constant insulin infusion, the half-time of serum insulin was calculated as 6 min. Compared with the known large variability in the absorption of intermediate-acting insulin, continuous subcutaneous insulin infusion offers a precise and reproducible way of insulin administration resulting in post-prandial serum insulin peaks sufficient to maintain near-normal blood glucose levels. The half-time of serum insulin during subcutaneous infusion corresponds to values for intravenous infusion given in the literature, indicating that local degradation of insulin in subcutaneous tissue is of minor importance.

Lauritzen, Torsten; Pramming, S

1983-01-01

55

Insulin Infusion Set: The Achilles Heel of Continuous Subcutaneous Insulin Infusion  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Continuous subcutaneous insulin infusion from an insulin pump depends on reliable transfer of the pumped insulin to the subcutaneous insulin depot by means of an insulin infusion set (IIS). Despite their widespread use, the published knowledge about IISs and related issues regarding the impact of placement and wear time on insulin absorption/insulin action is relatively small. We also have to acknowledge that our knowledge is limited with regard to how often patients encounter issues with IIS...

Heinemann, Lutz; Krinelke, Lars

2012-01-01

56

Numerical Simulation Study on the Coal Seam Pulse Water Infusion  

Directory of Open Access Journals (Sweden)

Full Text Available In the process of coal seam pulse water infusion, liquid-solid coupling effect exists in coal seam between the stress field and seepage field. Based on the basic principle of liquid-solid coupling, the dynamic liquid-solid coupling effect of stress and seepage field during coal seam pulse water infusion is simulated through secondary development of ABAQUS software, during this process the mathematical model of the strain accumulation model due to the periodic changes of pulse water pressure is embedded in SOIL module of ABAQUS software. The law of different parameters of pulse water infusion on the permeability of coal around the infusion hole is gotten. Numerical simulation results show that, during the process of coal seam high pressure pulse water infusion, the stress field and flow field are mutual influence and mutual restriction. The coupling of the stress and flow field have impact on the physical and mechanical properties of coal in front of the working face, these factors promote each other and preventing coal and gas outburst effectively. The permeability of coal increase significantly with the water infusion time prolong under constant water infusion pressure and frequency. The permeability of coal increase significantly with the water infusion pressure improving under constant water infusion time and frequency. The permeability of coal increase significantly with the water infusion frequency improving under constant water infusion pressure and time. So the pulse water infusion time needs to ensure a better effect of preventing coal and gas outburst is gotten. Meanwhile the high pressure pulse water infusion pressure needs to improve under the existing technical conditions and not cause big coal fissure. The frequency of pulse water infusion needs to improve under the existing technical conditions. This research results have great theoretical value and practical significance on revealing the mechanism of coal seam pulse water infusion on permeability, enhancing the validity of the technological parameters design in coal seam water infusion and implementing the technology in the site.

Meng Junqing

2014-01-01

57

Brain activity following esophageal acid infusion using positron emission tomography  

Digital Repository Infrastructure Vision for European Research (DRIVER)

AIM: To investigate symptoms and brain activity following esophageal acid infusion.METHODS: Fifteen healthy volunteers were recruited for the study. Hydrochloric acid (pH 1 and 2) and distilled water (pH 7) were randomly and repeatedly infused into the esophagus. The brain activity was evaluated by positron emission tomography. The severity of heartburn elicited by the infusion was rated on an auditory analog scale of 0-10.RESULTS: The severity of heartburn following each infusion showed a st...

Shigeyuki Kobayashi, Yasuhiko Abe

2010-01-01

58

An audit of hospital based outpatient infusions and a pilot program of community-based monoclonal antibody infusions.  

LENUS (Irish Health Repository)

INTRODUCTION: Infliximab, a chimeric monoclonal antibody to tumour necrosis factor alpha, is administered as an intravenous infusion requiring a costly hospital day case or inpatient admission. METHODS: An audit of all current therapies given by intravenous infusions in an outpatient setting in St Vincent\\'s University Hospital (SVUH) was undertaken. Furthermore, in conjunction with TCP homecare, we established in a general practise health clinic, the first Irish community infusion centre for the administration of infliximab in August 2006. RESULTS: All outpatient departments indicated that they would favour a centralized hospital infusion unit. There were no adverse events and the mean global satisfaction improved in the community infliximab infusion pilot programme of seven patients. CONCLUSION: This study suggests efficiencies in providing centralized infusion facilities, while the community based infusion of infliximab is feasible and safe in this small cohort and identifies the community infusion unit as a viable and cost efficient alternative for administration of infliximab.

Doran, J-P

2012-02-01

59

Epipodophyllotoxin and cisplatin on continuous infusion schedules  

International Nuclear Information System (INIS)

The Epipodophyllotoxins, VP16-213 and VM26, and the heavy metal cytotoxic agents, Cisplatin and its analogs, Spriogermanium and Gallium are discussed as representing classes of agents which in clinical trials are traditionally delivered on an intermittent bolus schedule to coincide with radiation therapy. The continuous infusion of VP16-213 has a strong rationale based upon pharmacokinetic considerations of the drug and schedule dependency in experimental tumor systems. The regional delivery of Cisplatin is examined and has demonstrated some exceptional therapeutic effects, particularly in brain tumors, although toxicity has been substantial. VP16-213 has practical limitations with regard to the infusion schedule relative to the insolubility of the agent in small volumes

60

Superselective arterial infusion and concomitant radiotherapy  

Energy Technology Data Exchange (ETDEWEB)

Superselective arterial infusion for patients with advanced head and neck cancer has been increasingly applied in Japan. We analyzed our experiences and evaluated the efficacy and safety of this treatment. Through October 1999 to March 2002, 29 patients, ranging in age between 33 and 71 years (median 52 years), received superselective intra-arterial infusion therapy of cisplatin (100-120 mg/m{sup 2}/week) with simultaneous intravenous infusion of thiosulfate for neutralizing cisplatin toxicity, and conventional concomitant extrabeam radiotherapy (65 Gy/26 f/6.5 weeks). Four patients were diagnosed with stage III and 25 with stage IV. Thirteen patients were considered contraindicated for surgery, and the other 16 patients rejected radical surgery. Primary tumor sites included paranasal sinus (11 patients), hypopharynx (7), oropharynx (6), oral cavity (4), and parotid gland (1). During the median follow-up period of 20 months, there was no apparent recurrence in 14 (48.3%) of 29 patients. Eleven (37.9%) patients died of disease, and three (10.3%) were alive with disease. In twenty-one patients (72.4%) the primary lesions were well-controlled. Acute toxic effects were moderate, and severe toxic events occurred in four cases, namely, methicillin-resistant staphylococcus aureus (MRSA) pneumonia, sepsis, tetraplasia, and osteoradionecrosis. We confirmed the effectiveness and safety of superselective arterial infusion and concomitant radiotherapy. Furthermore, we must establish the optimal procedures and schedule, as well as the indications for this treatment. This treatment protocol may improve the prognosis of patients with unresectable disease and patients rejecting surgical treatment. Further study in this particular area is needed. (author)

Homma, Akihiro; Suzuki, Fumiyuki; Inuyama, Yukio; Fukuda, Satoshi [Hokkaido Univ., Sapporo (Japan). School of Medicine

2003-05-01

 
 
 
 
61

Continuous ampicillin infusion as an alternative to intermittent infusion for adult inpatients: A case series.  

Science.gov (United States)

Intravenous ampicillin has been extensively used for various kinds of infections for more than fifty years. This drug is administered intermittently, which can result in missed or delayed drug administration and sleep interruption that can have a negative impact on the quality of life during hospitalization. Continuous infusion may solve these concerns. We reviewed the cases of five patients who were treated with continuous ampicillin infusions in our hospital. The ampicillin serum concentrations were from 11.3 to 32.8 ?g/mL, which was above the ampicillin MICs of the causative organisms, ?0.06 to 4 ?g/mL. Although the dosages given of ampicillin varied in each case, the serum concentrations showed a strong correlation with creatinine clearance (r(2) = 0.91). All the patients improved at the time of discharge, or transfer to another hospital, with no significant complications during the continuous infusion. Continuous ampicillin infusion could be a better alternative for frequent intermittent infusion for adult inpatients with infections due to ampicillin-susceptible organisms. PMID:24972584

Ogawa, Taku; Kasahara, Kei; Ikawa, Kazuro; Shigeta, Junichi; Komatsu, Yuko; Kuruno, Noriko; Uno, Kenji; Maeda, Koichi; Mikasa, Keiichi

2014-10-01

62

Infusion MR arteriography during hepatic arterial infusion chemotherapy. Evaluation of clinical usefulness  

International Nuclear Information System (INIS)

We developed a new method of infusion MR arteriography (IMRA) via an implantable port system using an infusion pump for the evaluation of drug distribution during hepatic arterial infusion chemotherapy. The purposes of this study were to optimize the method and evaluate its clinical usefulness. We used 3D-T1 turbo field echo (TFE) as the most suitable sequence for IMRA according to the results of a phantom model experiment. We examined 33 cases of liver cancer that had been treated by arterial infusion chemotherapy via the port system. The following investigations were performed: degree of tumor enhancement, intra- and extra- hepatic perfusion abnormality, and related toxicity. The evaluation of images was performed separately by two radiologists. IMRA provided good images of contrast enhancement, to reveal the perfusion patterns. The treatment response rate in the tumor group with well enhancement was higher than that of the group with poor enhancement (p<0.0001). Extrahepatic perfusion was well visualized and was correlated with toxicity (p<0.0001). IMRA is a useful method to evaluate drug perfusion for the optimization of arterial infusion chemotherapy. (author)

63

Management of Severe Hyponatremia: Infusion of Hypertonic Saline and Desmopressin or Infusion of Vasopressin Inhibitors?  

Science.gov (United States)

Abstract: Rapid correction of severe hyponatremia carries the risk of osmotic demyelination. Two recently introduced methods of correction of hyponatremia have diametrically opposite effects on aquaresis. Inhibitors of vasopressin V2 receptor (vaptans) lead to the production of dilute urine, whereas infusion of desmopressin causes urinary concentration. Identification of the category of hyponatremia that will benefit from one or the other treatment is critical. In general, vaptans are effective in hyponatremias presenting with concentrated urine and, with the exception of hypovolemic hyponatremia, can be used as their primary treatment. Desmopressin is effective in hyponatremias presenting with dilute urine or developing urinary dilution after saline infusion. In this setting, desmopressin infusion helps prevent overcorrection of the hyponatremia. Monitoring of the changes in serum sodium concentration as a guide to treatment changes is imperative regardless of the initial treatment of severe hyponatremia. PMID:25247759

Tzamaloukas, Antonios H.; Shapiro, Joseph I.; Raj, Dominic S.; Murata, Glen H.; Glew, Robert H.

2014-01-01

64

Cardiovascular toxicity of cryopreserved cord blood cell infusion.  

Science.gov (United States)

Although infusion of cryopreserved bone marrow or peripheral blood stem cell is associated with a variety of symptoms, there have been no reports detailing the data of infusion-related toxicities of cryopreserved cord blood (CB) units. We prospectively evaluated the incidence and significance of infusion-related toxicities in 34 adult patients undergoing unrelated CB transplantation. Cryopreserved CB units were thawed and immediately infused, unfiltered, through a central intravenous catheter without further manipulation. Heart rate, blood pressure, oxygen saturation and clinical symptoms were recorded during and after infusion. Twenty-four percent of patients experienced non-cardiovascular toxicities related to infusion. The incidence of systolic and diastolic hypertension and bradycardia was 58, 64 and 32%, respectively. Although three patients (9%) with severe systolic hypertension after the infusion required treatment with antihypertensive agents, no patients experienced life-threatening side effects or needed discontinuation of CB unit infusion. Patient or transplant characteristics had no effect on the hypertension and bradycardia related to the infusion of CB. These data suggest that infusion of cryopreserved CB without further manipulation after thawing is safe and well tolerated. However, cardiovascular toxicities including hypertension and bradycardia were frequently observed. PMID:18209718

Konuma, T; Ooi, J; Takahashi, S; Tomonari, A; Tsukada, N; Kobayashi, T; Sato, A; Kato, S; Kasahara, S; Ebihara, Y; Nagamura-Inoue, T; Tsuji, K; Tojo, A; Asano, S

2008-05-01

65

[Neurological symptoms following infusion of infliximab].  

Science.gov (United States)

Infliximab is indicated for treatment of plaque psoriasis when traditional systemic therapy is inadequate or inappropriate. The treatment is efficient but also carries a risk of serious adverse drug events. We describe a case of neurological symptoms following the first infusion of infliximab in a patient treated for plaque psoriasis. The patient fully recovered after sensation of the therapy. We believe the symptoms could be related to infliximab and stress the importance of thorough information of patients treated with tumour necrosis factor-?-inhibitors, also about the risk of serious adverse events. PMID:23031302

Bebe, Anna C K M; Harboe, Kirstine Moll; Nøjgaard, Camilla

2012-10-01

66

Investigations about new infusion pumps for medical applications  

Digital Repository Infrastructure Vision for European Research (DRIVER)

In medical infusion technology there is a wide range of applications with each of them putting specific demands on the infusion pump, such as accuracy and range of delivery rates. While for parenteral feeding high delivery rates with lower demands on accuracy are needed, very low delivery rates and high demands on accuracy are required in intensive-care medicine. There are different types of pump systems in use to cover the whole range of applications in infusion therapy. Currently there is n...

Wolter, Frank

2013-01-01

67

INTRAVENOUS FENTANYL INFUSION AS AN ANALAGESIC AGENTS FOR LABOR PAIN  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Introduction. There are few studies about intravenous fentanyl infusion for reduce labor pain. This study evaluate the usefulness of intravenous fentanyl infusion for labor analgesia. Methods. Seventy seven healthy pregnant women were randomized to recive 1.5-2.5µg/kg/hr intravenous fentanyl infusion (interventional group) or placebo (control group). Maternal labor pain intensity, systolic, diastolic and mean arterial blood pressure, pulse and respiratory rate, frequency of nausea and v...

Soltani Nezhad, H.; SH ARAM; Monajjemi, Z.; Jaafar-zadeh, L.

2001-01-01

68

Portal 5-hydroxytryptophan infusion enhances glucose disposal in conscious dogs  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Intraportal serotonin infusion enhances net hepatic glucose uptake (NHGU) during glucose infusion but blunts nonhepatic glucose uptake and can cause gastrointestinal discomfort and diarrhea at high doses. Whether the serotonin precursor 5-hydroxytryptophan (5-HTP) could enhance NHGU without gastrointestinal side effects during glucose infusion was examined in conscious 42-h-fasted dogs, using arteriovenous difference and tracer ([3-3H]glucose) techniques. Experiments consisted of equilibratio...

Moore, Mary Courtney; Kimura, Kazuhiro; Shibata, Haruki; Honjoh, Tsutomu; Saito, Masayuki; Everett, Carrie A.; Smith, Marta S.; Cherrington, Alan D.

2005-01-01

69

Green Urine Discoloration due to Propofol Infusion: A Case Report  

Digital Repository Infrastructure Vision for European Research (DRIVER)

We present a 19-year-old man who excreted green urine after propofol infusion. The patient was admitted to our hospital for injuries sustained in a traffic accident and underwent surgery. After starting continuous infusion of propofol for postoperative sedation, his urine became dark green. Serum total bilirubin and urine bilirubin were both elevated. We believe that the green discoloration of the urine was caused by propofol infusion and was related to impaired enterohepatic circulation and ...

Nobuki Shioya; Yoriko Ishibe; Shigehiro Shibata; Hideyuki Makabe; Shigenori Kan; Naoya Matsumoto; Gaku Takahashi; Yasuhiko Yamada; Shigeatsu Endo

2011-01-01

70

Quantitative evaluation of valvular regurgitation by 133Xenon infusion  

International Nuclear Information System (INIS)

Mitral and aortic regurgitation was evaluated by X-ray, dye dilution bolus, and 133Xenon infusion methods in 24 patients with mitral, aortic or both valve lesions. Good reproducibility was found using the 133Xenon infusion method. The regurgitant fraction estimated by 133Xenon constant infusion method correlates well with the results of the dye dilution method in mitral regurgitation as well as in aortic regurgitation. The 133Xenon infusion method is well-suited for quantitative evaluation of mitral and aortic regurgitation. For its simplicity, it is therefore recommended for further clinical evaluation in pharmacodynamic and preoperative studies. (author)

71

Clinical applications of continuous infusion chemotherapy ahd concomitant radiation therapy  

International Nuclear Information System (INIS)

This book presents information on the following topics: theoretical basis and clinical applications of 5-FU as a radiosensitizer; treatment of hepatic metastases from gastro intestingal primaries with split course radiation therapy; combined modality therapy with 5-FU, Mitomycin-C and radiation therapy for sqamous cell cancers; treatment of bladder carcinoma with concomitant infusion chemotherapy and irradiation; a treatment of invasiv bladder cancer by the XRT/5FU protocol; concomitant radiation therapy and doxorubicin by continuous infusion in advanced malignancies; cis platin by continuous infusion with concurrent radiation therapy in malignant tumors; combination of radiation with concomitant continuous adriamycin infusion in a patient with partially excised pleomorphic soft tissue sarcoma of the lower extremeity; treatment of recurrent carcinoma of the paranasal sinuses using concomitant infusion cis-platinum and radiation therapy; hepatic artery infusion for hepatic metastases in combination with hepatic resection and hepatic radiation; study of simultaneous radiation therapy, continuous infusion, 5FU and bolus mitomycin-C; cancer of the esophagus; continuous infusion VP-16, bolus cis-platinum and simultaneous radiation therapy as salvage therapy in small cell bronchogenic carcinoma; and concomitant radiation, mitomycin-C and 5-FU infusion in gastro intestinal cancer

72

Pulsatile versus steady infusions for hepatic artery chemotherapy  

International Nuclear Information System (INIS)

Hepatic artery chemotherapy for unresectable liver tumors requires an even distribution of the drugs in the tumor or vascular bed. This cannot be determined angiographically because the drugs are infused at a much lower rate than the contrast media. It is easy, however, to determine the quality of the perfusion by injecting a small volume of Tc-99m MAA in one of the side ports while chemotherapeutic agent is being infused at the same rate. Usually this shows a uniform, satisfactory distribution of isotope. Occasionally, however, some areas fail to receive Tc-99m in spite of what appears to be a good position of the catheter tip. Since ''streaming'' of the infused drugs has been blamed for their uneven distribution, the authors decided to compare the usual steady flow infusions with infusions made pulsatile by the addition of a pulsing device (Gianturco Pump) attached to the infusion tubing. Eighty-three patients were studied with steady as well as pulsatile infusions. In 16 of these patients the perfusion pattern was definitely changed by the pulsatile infusion. In one patient the pulsatile mode resulted in an unwanted gastric perfusion. In 5 patients the distribution was improved in one hepatic lobe and in 10 patients it was improved in both lobes. These results show that hepatic artery perfusions can occasionally be improved by pulsing the infusate. However, pulsing can produce the unwanted perfusion of extra-hepatic areas

73

Rapid Infusion Rituximab for Maintenance Therapy: Is It Feasible?  

Science.gov (United States)

Rituximab is an anti-CD-20 monoclonal antibody used in the management of lymphoproliferative disorders. The use of maintenance rituximab has improved progression free survival and overall survival in follicular lymphomas. Although rapid rituximab infusions have been studied extensively, there is little data on the use of rapid infusions during maintenance therapy for low grade lymphomas. The primary objective of this retrospective analysis was to evaluate the incidence of Grade 3 and 4 toxicities with maintenance rapid infusion rituximab according to the Common Terminology Criteria for Adverse Events version 4 (CTC v. 4). Secondary objectives included evaluating all grade infusion related adverse events and correlation of adverse events with varying schedules of rituximab maintenance therapy. All patients who received rapid infusion rituximab as maintenance therapy for low grade lymphoma between December 2007 and November 2011 were included. Rapid rituximab infusions were administered over 90 minutes. Demographic, laboratory and clinical data were collected. A total of 109 patients received 647 rapid rituximab infusions. Three patients experienced an adverse reaction which resulted in one grade 1 infusion reaction and three grade 3 infusion reactions. No patients required hospitalization. All 3 patients received pharmacological and/or supportive care to relieve symptoms associated with the reaction. PMID:24288618

Patel, Jolly; Ho, Melissa; Bello, Celeste; Djulbegovic, Benjamin; Sokol, Lubomir; Wetzstein, Gene

2013-01-01

74

A comparison of three different target-controlled remifentanil infusion rates during target-controlled propofol infusion for oocyte retrieval  

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OBJECTIVE: To evaluate the effects of three different target-controlled remifentanil infusion rates during target-controlled propofol infusion on hemodynamic parameters, pain, sedation, and recovery score during oocyte retrieval. METHODS: Sixty-nine women were scheduled for oocyte retrieval. Target-controlled propofol infusion at an effectsite concentration of 1.5 ?g/mL was instituted. The patients were randomly allocated to receive remifentanil at an effect-site concentration of either ...

Demet Coskun; Berrin Gunaydin; Ayca Tas; Gozde Inan; Hulya Celebi; Kadir Kaya

2011-01-01

75

RF tumor ablation with internally cooled electrodes and saline infusion: what is the optimal location of the saline infusion?  

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Abstract Background Radiofrequency ablation (RFA) of tumors by means of internally cooled electrodes (ICE) combined with interstitial infusion of saline may improve clinical results. To date, infusion has been conducted through outlets placed on the surface of the cooled electrode. However, the effect of infusion at a distance from the electrode surface is unknown. Our aim was to assess the effect of perfusion distance (PD) on the coagulation geometry and deposited power duri...

Cruz Ignacio; Gonzalez Ana; Subiró Jorge; Sousa Ramón; Grande Luis; Güemes Antonio; Burdío José M; Navarro Ana; Berjano Enrique J; Burdío Fernando; Castiella Tomás; Tejero Eloy; Lozano Ricardo; de Gregorio Miguel A

2007-01-01

76

Intraarterial infusion chemotherapy for the treatment of metastatic liver cancer  

International Nuclear Information System (INIS)

Some techniques of the most recent interventional radiology are very useful for the treatment of metastatic liver cancer and changing the style of hepatic infusion chemotherapy. This report shows our latest results and methods of hepatic infusion chemotherapy for metastatic liver cancer. 1. For the catheter placement, a new catheterization route via the left subclavian artery into the hepatic artery was developed and performed in 132 cases. Superselective catheterization succeeded in 123 cases (93.2 %). This procedure is less invasive than laparotomy and less troublesome than other percutaneous routes. 2. For useful infusion system, an implantable injection port ''Reservoir'' was developed and it was used in 87 cases. This method makes arterial infusion chemotherapy easy, and imploves their quality of life. 3. To acquire adequate drug delivery, arterial redistribution by steel coils was done, and 109 arteries in 80 cases were occluded. This method is very useful to make multiple hepatic artery single and it is important to avoid gasroduodenal complications. 4. Now, using these techniques, the phase II study of 5FU, ADM, MMC combined hepatic infusion in patients with non-resectable metastatic liver cancer is done. Up to this time, such a phase study on arterial infusion chemotherapy was difficult because of technical problems, but these new techniques make it possible. In conclusion, these new methods change the style and conception of hepatic infusion, and these make ption of hepatic infusion, and these make much progress on the treatment of patients with metastatic liver cancer. (author)

77

Inhibition of endogenous lactate turnover with lactate infusion in humans  

Energy Technology Data Exchange (ETDEWEB)

The extent to which lactate infusion may inhibit endogenous lactate production, though previously considered, has never been critically assessed. To examine this proposition, single injection tracer methodology (U-{sup 14}C Lactate) has been used for the estimation of lactate kinetics in 12 human subjects under basal conditions and with the infusion of sodium lactate. The basal rate of lactate turnover was measured on a day before the study with lactate infusion, and averaged 63.7 + 5.5 mg/kg/h. Six of these individuals received a stable lactate infusion at an approximate rate of 160 mg/kg/h, while the remaining six individuals were infused at the approximate rate of 100 mg/kg/h. It has been found that stable lactate infused at rates approximating 160 mg/kg/h consistently produced a complete inhibition of endogenous lactate production. Infusion of lactate at 100 mg/kg/h caused a lesser and more variable inhibition of endogenous lactate production (12% to 64%). In conclusion, lactate infusion significantly inhibits endogenous lactate production.

Searle, G.L.; Feingold, K.R.; Hsu, F.S.; Clark, O.H.; Gertz, E.W.; Stanley, W.C. (Veterans Administration Medical Center, San Francisco, CA (USA))

1989-11-01

78

Inhibition of endogenous lactate turnover with lactate infusion in humans  

International Nuclear Information System (INIS)

The extent to which lactate infusion may inhibit endogenous lactate production, though previously considered, has never been critically assessed. To examine this proposition, single injection tracer methodology (U-14C Lactate) has been used for the estimation of lactate kinetics in 12 human subjects under basal conditions and with the infusion of sodium lactate. The basal rate of lactate turnover was measured on a day before the study with lactate infusion, and averaged 63.7 + 5.5 mg/kg/h. Six of these individuals received a stable lactate infusion at an approximate rate of 160 mg/kg/h, while the remaining six individuals were infused at the approximate rate of 100 mg/kg/h. It has been found that stable lactate infused at rates approximating 160 mg/kg/h consistently produced a complete inhibition of endogenous lactate production. Infusion of lactate at 100 mg/kg/h caused a lesser and more variable inhibition of endogenous lactate production (12% to 64%). In conclusion, lactate infusion significantly inhibits endogenous lactate production

79

Energy Management for School Administrators: Curriculum Infusion Facilities Audit.  

Science.gov (United States)

Presented are the state guidelines and framework for the infusion of energy education into the Texas public school curriculum. Designed to assist teachers, administrators, and other school personnel in the process of infusing energy education concepts, this guide focuses on the basic concerns and needs of the people as related to energy and…

Education Service Center Region 7, Kilgore, TX.

80

Brain activity following esophageal acid infusion using positron emission tomography  

Directory of Open Access Journals (Sweden)

Full Text Available AIM: To investigate symptoms and brain activity following esophageal acid infusion.METHODS: Fifteen healthy volunteers were recruited for the study. Hydrochloric acid (pH 1 and 2 and distilled water (pH 7 were randomly and repeatedly infused into the esophagus. The brain activity was evaluated by positron emission tomography. The severity of heartburn elicited by the infusion was rated on an auditory analog scale of 0-10.RESULTS: The severity of heartburn following each infusion showed a step-wise increase with increasing acidity of the perfusate. The heartburn scores were significantly higher in the second pH 1 infusion compared with the first infusion. Acid and distilled water infusion induced activation of various brain areas such as the anterior insula, temporal gyrus, and anterior/posterior cingulate cortex. At pH 1 or 2, in particular, activation was observed in some emotion-related brain areas such as the more anterior part of the anterior cingulate cortex, parahippocampal gyrus, or the temporal pole. Strong activation of the orbitofrontal cortex was found by subtraction analysis of the two second pH 1 infusions, with a significant increase of heartburn symptoms.CONCLUSION: Emotion-related brain areas were activated by esophageal acid stimulation. The orbitofrontal area might be involved in symptom processing, with esophageal sensitization induced by repeated acid stimulation.

Shigeyuki Kobayashi, Yasuhiko Abe, Manabu Tashiro, Tomoyuki Koike, Katsunori Iijima, Akira Imatani, Shuichi Ohara, Satoshi Watanabe, Shin Fukudo, Tooru Shimosegawa

2010-11-01

 
 
 
 
81

Superselective intraarterial infusion therapy for head and neck carcinomas  

International Nuclear Information System (INIS)

We report the results of superselective intraarterial cisplatin (CDDP) infusion therapy combined with irradiation for 23 patients, mainly advanced head and neck carcinoma. All patients received intraarterial CDDP infusions with intravenous sodium thiosulfate (STS) neutralization. CDDP infusion was performed by the Seldinger's technique in 16 patients and by the implanted intraarterial reservoir system in 7 patients. STS was also infused by the reservoir system implanted at the forearm in most patients. An overall response was observed in 21 of the 23 (91.3%) patients. Complete and partial responses were achieved in 16 (69.6%) and 5 (21.7%) patients, respectively. There were no patients with worse than grade III complications. We concluded that superselective intraarterial infusion therapy with a high dose of CDDP and STS was very effective for the management of advanced head and neck carcinomas and we recommend the implantable reservoir system for both CDDP and STS administration as an easy and low-invasive method. (author)

82

Experimental study on intra-arterial infusion of basic fibroblast growth factor in the ischemic limbs of rabbit model  

International Nuclear Information System (INIS)

Objective: To evaluate the effect of intra-arterial infusion of basic fibroblast growth factor (bFGF) on improving neovascularization, vascular perfusion and the function of partially ischemic limbs of rabbits. Methods: Twenty-seven New Zealand male rabbits were selected. Partial ischemia model was induced by surgical ligation of the primary branches of right femoral artery in each animal, and the left hind limb of each animal was served as a nonischemic control. Then, 27 rabbits were randomly assigned to three groups: intra-arterial (IA) infusion of bFGF (n=9), intravenous (IV) infusion of bFGF and IA infusion of saline (n=9). Infusion was separately performed immediately after vascular ligation, 8th and 15th days post-surgery with 10 ?g (4 ml) of bFGF per-time (or the same volume of saline). The differences between three groups and between ischemic and nonischemic limbs of the same group were compared and evaluated by the following indexes: (1) vessel section count (VSC), vessel section surface area (VSS) and vessel section perimeter (VSP) in the field of ischemic muscle tissues taken at 22nd day postoperatively; (2) capillary refilling time of ischemic limbs; and (3) functional and trophic changes of ischemic limbs. Statistical differences were evaluated by one-way ANOVA and T test. Results: VSC, VSS and VSP of the IA-bFGF group were significantly increased than those of the IV-bFGF and IA-saline groups (P<0.01). At 22nd day postoperatively, the capillary refilliny postoperatively, the capillary refilling time, new hair growth, the appearance and function of all ischemic limbs in IA-bFGF group were approximately normal. However, in IA-saline group, the ischemic changes, capillary refilling time and the function of ischemic limbs were not improved significantly. All the indexes of IV-bFGF group showed no difference statistically from those of IA-saline group. Conclusions: This experimental study identifies that intra-arterial infusion of bFGF may significantly promote neovascularization and vascular perfusion in ischemic limbs, suggesting that a better effect may be obtained with IA-infusion bFGF than that of IV-infusion bFGF. (authors)

83

21 CFR 880.2420 - Electronic monitor for gravity flow infusion systems.  

Science.gov (United States)

...2010-04-01 false Electronic monitor for gravity flow infusion systems...Devices § 880.2420 Electronic monitor for gravity flow infusion systems...Identification. An electronic monitor for gravity flow infusion...

2010-04-01

84

Rata-rata Lama Hari Pemasangan Infus dalam Terjadinya Flebitis pada Pasien yang Dipasang Infus di RSUP Haji Adam Malik Medan  

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Lama hari pemasangan infus pada pasien yang dipasang infus memiliki resiko tinggi terjadi flebitis dan kejadiannya tergantung pada kondisi kesehatan secara keseluruhan dan lamanya pemasangan infus. Penelitian ini bertujuan untuk mendapatkan rata-rata lama hari pemasangan infus dalam terjadinya flebitis pada pasien yang dipasang infus di RSUP Haji Adam Malik Medan. Penelitian ini menggunakan desain deskriptif dengan jumlah sampel sebanyak 60 orang responden yang diambil dengan teknik purpos...

Mardiah, Lia

2012-01-01

85

Advancing medication infusion safety through the clinical integration of technology.  

Science.gov (United States)

Adverse drug events resulting from errors in prescribing or administering medications are preventable. Within a hospital system, numerous technologies are employed to address the common sources of medication error, including the use of electronic medical records, physician order entry, smart infusion pumps, and barcode medication administration systems. Infusion safety is inherently risky because of the high-risk medications administered and the lack of integration among the stand-alone systems in most institutions. Intravenous clinical integration (IVCI) is a technology that connects electronic medical records, physician order entry, smart infusion pumps, and barcode medication administration systems. It combines the safety features of an automatically programmed infusion pump (drug, concentration, infusion rate, and patient weight, all auto-programmed into the device) with software that provides visibility to real-time clinical infusion data. Our article describes the characteristics of IVCI at WellSpan Health and its impact on patient safety. The integrated infusion system has the capability of reducing medication errors, improving patient care, reducing in-facility costs, and supporting asset management. It can enhance continuous quality improvement efforts and efficiency of clinical work flow. After implementing IVCI, the institution realized a safer patient environment and a more streamlined work flow for pharmacy and nursing. PMID:24145584

Gerhart, Donald; O'Shea, Kristen; Muller, Sharon

2013-01-01

86

Radiofrequency ablation during continuous saline infusion can extend ablation margins  

Directory of Open Access Journals (Sweden)

Full Text Available AIM: To determine whether fluid injection during radiofrequency ablation (RFA can increase the coagulation area. METHODS: Bovine liver (1-2 kg was placed on an aluminum tray with a return electrode affixed to the base, and the liver was punctured by an expandable electrode. During RFA, 5% glucose; 50% glucose; or saline fluid was infused continuously at a rate of 1.0 mL/min through the infusion line connected to the infusion port. The area and volume of the thermocoagulated region of bovine liver were determined after RFA. The Joule heat generated was determined from the temporal change in output during the RFA experiment. RESULTS: No liquid infusion was 17.3 ± 1.6 mL, similar to the volume of a 3-cm diameter sphere (14.1 mL. Mean thermocoagulated volume was significantly larger with continuous infusion of saline (29.3 ± 3.3 mL than with 5% glucose (21.4 ± 2.2 mL, 50% glucose (16.5 ± 0.9 mL or no liquid infusion (17.3 ± 1.6 mL. The ablated volume for RFA with saline was approximately 1.7-times greater than for RFA with no liquid infusion, representing a significant difference between these two conditions. Total Joule heat generated during RFA was highest with saline, and lowest with 50% glucose. CONCLUSION: RFA with continuous saline infusion achieves a large ablation zone, and may help inhibit local recurrence by obtaining sufficient ablation margins. RFA during continuous saline infusion can extend ablation margins, and may be prevent local recurrence.

Toru Ishikawa

2013-01-01

87

Hepatobiliary scintigraphy in patients receiving hepatic artery infusion chemotherapy  

International Nuclear Information System (INIS)

Hepatic artery infusion chemotherapy is used in the treatment of certain selected hepatic tumors, especially metastatic adenocarcinoma of the colon. Chemical cholecystitis has been recognized recently as a complication of hepatic artery infusion chemotherapy. The authors performed hepatobiliary scans on ten patients receiving hepatic artery infusion chemotherapy. All ten patients had abnormal hepatobiliary scintigraphy. They present case reports of three patients with abnormal hepatobiliary scans who have required cholecystectomy for symptoms of chemical cholecystitis to illustrate the clinical, scintigraphic, and pathologic findings in these patients

88

Intestinal levodopa infusion: the Belgian experience.  

Science.gov (United States)

Data concerning efficacy, safety, and patient satisfaction of levodopa/carbidopa intestinal gel (LCIG, Duodopa, AbbVie, Wavre, Belgium) infusion in routine clinical practice were needed to maintain reimbursement of the drug in Belgium. Patients with advanced Parkinson's disease in 27 neurology centers across Belgium were included. Of 100 patients who underwent naso-intestinal (NI) evaluation with LCIG, 67 received permanent treatment with LCIG via percutaneous endoscopic gastrostomy and jejunal tube (PEG/J). Efficacy was evaluated at baseline (on levodopa) and during a follow-up (FU) visit (on LCIG) using the Unified Parkinson's Disease Rating Scale (UPDRS) IV. Patient appraisal of the Duodopa system was evaluated using a visual analog scale for therapy compliance, user-friendliness, and global appreciation. Safety was assessed by reporting suspected adverse drug reactions (ADRs) and medical device-related complaints. FU evaluations were conducted in 37 patients. Significant improvement at FU was observed for motor complications (UPDRS IV) as the mean change from baseline to FU was -6.3 (95 % CI -8.1 to -4.5). Patient appraisal showed high scores for hospital delivery, user-friendliness, and patient global appreciation, as well as family appreciation of the system on daily life. Few ADRs and system malfunctions were reported, with no unexpected ADRs. In conclusion, the symptoms and impact of Parkinsonism improved markedly when LCIG PEG/J was initiated. PMID:24379105

Pickut, Barbara Anne; van der Linden, Chris; Dethy, Sophie; Van De Maele, Hilde; de Beyl, Diederik Zegers

2014-06-01

89

Pain and Gaps in IT Infusion  

Science.gov (United States)

The process of adopting a new information technology 'X' within geoscience research projects is hindered by two strong barriers: The pain associated with learning about, adopting and adapting to X, and corresponding gaps in the 'ease-of-adoption' process left by the builders of X. As builders and providers of two such X's we discuss several lessons learned from two distinct points along the data pipeline (data acquisition, storage, retrieval, archival, cleaning, provenance, browsing and analysis). We begin with work at Microsoft Research to generalize the CUAHSI Observations Data Model to a "next generation" Environmental Data Model (EDM) with the idea of supporting trans-disciplinary information across remote sensing, in situ, sample analysis, archival, and model data spaces. We then turn to an in situ sensor network microserver developed through NASA support for harsh environment data acquisition. The primary 'IT infusion' candidate research project here is SEAMONSTER, the Southeast Alaska Monitoring Network for Science, Telecommunications, Education and Research. We trace the adoption pathway, including gaps and pain, from deployment through to data registration on an EDM data catalog server. We discuss architecture, documentation and technical support in terms of an end-result success metric: How easily can this project's open data results be discovered and used?

Fatland, D. R.; van Ingen, C.; Beran, B.; Heavner, M.; Habermann, M.; Berner, L.

2008-12-01

90

Field comparison of Bermuda-hay infusion to infusions of emergent aquatic vegetation for collecting female mosquitoes.  

Science.gov (United States)

Field experiments were conducted in east-central Alabama in 2003 and 2004 to compare the attractiveness of selected gravid-trap infusions to ovipositing female mosquitoes. Comparisons were made among infusions of the following plants: Bermuda hay, Cynodon dactylon, and 3 species of emergent aquatic plants typical of Culex larval habitats, i.e., soft rush, Juncus effusus; a common sedge, Rhynchospora corniculata; and broad-leaf cattail, Typha latifolia. Experiments were conducted at a site in Lee County, AL, with an abundance of common nuisance mosquitoes, including Culex quinquefasciatus and Aedes albopictus. Carbon dioxide-baited miniature light traps were operated concurrently with gravid traps to provide an activity index of mosquito species at the site. Gravid traps with hay infusion collected the greatest numbers of Cx. quinquefasciatus and Culex restuans females (2003). The results indicate that hay infusion is highly attractive to Cx. quinquefasciatus and is the infusion of choice for collecting females of this species in gravid traps. In the case of Ae. albopictus, infusions were not determined to be significantly different from one another in their attractiveness to gravid females. In general, females of Cx. quinquefasciatus and Cx. restuans demonstrated selectivity when choosing an oviposition site, whereas Ae. albopictus females did not. Factors associated with the oviposition biology of the latter species most likely account for their lack of preference for any single infusion type. PMID:17847842

Burkett-Cadena, Nathan D; Mullen, Gary R

2007-06-01

91

A new miniature, open-loop, extracorporeal insulin infusion pump.  

Science.gov (United States)

This extracorporeal insulin infuser has been designed to be compact, simple to operate, and suitable either for clinical investigations of insulin-dependent diabetes mellitus or for long term treatment of the condition. A syringe driver of unconventional design is used, and the syringe will be available prefilled with insulin, specially formulated at standard strength for long term infusion. The device is electronically controlled to give variable rates of basal infusion, preset by switch and supplemented by bolus infusions demanded by pushbutton prior to meals. Sufficient insulin is carried in the syringe to meet the needs of most diabetics for at least a week without refilling, and the battery life is commensurately long. Signalling of the mealtime dose regime, and of alarm and failure conditions is by audible means. Insulin will most commonly be delivered subcutaneously, though other routes are possible. PMID:6887820

Rothwell, D; Sutherland, I A; Pickup, J C; Bending, J J; Keen, H; Parsons, J A

1983-07-01

92

Radionuclide localization of intraarterial infusions in head and neck cancer  

International Nuclear Information System (INIS)

The therapeutic advantage of intraarterial infusion chemotherapy depends upon delivery of a high drug concentration to the entire tumor bulk with maximum sparing of critical normal tissues. It is clear that successful application of regional therapy must include methodology to assess quantitatively and qualitatively the infused area. /sup 99m/Tc macroaggregated albumin (Tc-MAA) injected intraarterially is held on first pass in the arteriolar capillary bed, thus providing a map of blood flow distribution. Analog and digital planar images and single photon emission computed tomography (SPECT) after Tc-MAA injections provide static and transaxial tomographic images of head and neck intraarterial infusions. SPECT can be viewed as an endless movie-type display, thus producing a rotating cimematic display. These radionuclide localization techniques provide a three-dimensional delineation of the tissues infused, including subsurface details not appreciated with dye injection alone. These procedures should be considered an integral part of intraarterial therapy of head and neck cancer

93

Gas cluster ion beam infusion processing of semiconductors  

Energy Technology Data Exchange (ETDEWEB)

The application of gas cluster ion beam (GCIB) infusion in advanced IC fabrication is described. GCIB processes for surface modifications, additive (junction formation, deposition) and subtractive (etch) processing are discussed.

MacCrimmon, R. [Epion Corporation, 37 Manning Road, Billerica, MA 01821 (United States)]. E-mail: rmaccrimmon@epion.com; Hautala, J. [Epion Corporation, 37 Manning Road, Billerica, MA 01821 (United States); Gwinn, M. [Epion Corporation, 37 Manning Road, Billerica, MA 01821 (United States); Sherman, S. [Epion Corporation, 37 Manning Road, Billerica, MA 01821 (United States)

2006-01-15

94

Infusing Social Responsibility into the Curriculum and Cocurriculum: Campus Examples  

Science.gov (United States)

This chapter highlights good practices and lessons learned for infusing social responsibility--contributing to the larger community and taking seriously the perspectives of others--as outcomes of college.

Reason, Robert D.

2013-01-01

95

Administering a glyceryl trinitrate infusion: big is not always best  

Science.gov (United States)

With the use of some simple calculations it can be demonstrated that the choice of cannula and initial glyceryl trinitrate (GTN) infusion rate for patients with acute left ventricular failure (LVF) requires some careful thought. If a GTN infusion is commenced at a rate of 1?ml/h, a critically unwell patient with a large cannula—for example, a grey cannula—will have to wait over 6?min for the drug to enter the body. This compares with 1.5?min for a pink cannula at the same infusion rate. If a large?diameter cannula is chosen for these patients, then a fast initial infusion rate should also be chosen to ensure that the GTN begins to act quickly. The rate can later be adjusted depending on clinical conditions. PMID:17513541

Reed, Matthew J

2007-01-01

96

A new infusion pathway monitoring system utilizing electrostatic induced potential.  

Science.gov (United States)

We have developed a new infusion pathway monitoring system employing linear integrated circuits and a low-power 8-bit single chip microcomputer. The system is available for hospital and home use and it constantly monitors the intactness of the pathway. The sensor is an electro-conductive polymer electrode wrapped around the infusion polyvinyl chloride infusion tube. This records an AC (alternating current) voltage induced on the patient's body by electrostatic coupling from the normal 100 volt, 60 Hz AC power line wiring field in the patient's room. If the injection needle or infusion tube becomes detached, then the system detects changes in the induced AC voltage and alerts the nursing station, via the nurse call system or PHS (personal handy phone System). PMID:16817637

Maki, Hiromichi; Yonezawa, Yoshiharu; Ogawa, Hidekuni; Ninomiya, Ishio; Sada, Kouji; Hamada, Shingo; Hahn, Alien W; Caldwell, W Morton

2006-01-01

97

The Infusion of Multicultural Teaching in the Classroom.  

Science.gov (United States)

Multicultural education can be infused into the existing curriculum to help students become less ethnocentric and more cosmopolitan. Multicultural lessons dealing with numerals, abacus, calendars, and money exchange that were implemented successfully into a mathematics unit are discussed. (DF)

Yao, Esther Lee

1984-01-01

98

Infusion device standardisation and dose error reduction software.  

Science.gov (United States)

In 2004, the National Patient Safety Agency (NPSA) released a safety alert relating to the management and use of infusion devices in England and Wales. The alert called for the standardisation of infusion devices and a consideration of using centralised equipment systems to manage device storage. There has also been growing interest in smart-pump technology, such as dose error reduction software (DERS) as a way to reduce IV medication errors. However, questions remain about the progress that has been made towards infusion device standardisation and the adoption of DERS. In this article, the authors report the results of a survey investigating the extent to which the standardisation of infusion devices has occurred in the last 10 years and centralised equipment libraries are being used in practice, as well as the prevalence of DERS use within the UK. Findings indicate that while reported standardisation levels are high, use of centralised equipment libraries remains low, as does DERS usage. PMID:25062367

Iacovides, Ioanna; Blandford, Ann; Cox, Anna; Franklin, Bryony Dean; Lee, Paul; Vincent, Christopher J

2014-07-01

99

Role of saline infusion sonography in abnormal uterine bleeding  

Directory of Open Access Journals (Sweden)

Conclusions: We found Saline Infusion Sonography to be an easy and safe procedure, though being less sensitive, it cannot replace hysteroscopy as a whole. Though hysteroscopy is a gold standard, saline infusion sonography is an easy, safe procedure for diagnosing intracavitary pathologies in low resource setting and despite being less sensitive, it can still reduce the number of hysteroscopies. [Int J Reprod Contracept Obstet Gynecol 2013; 2(4.000: 533-538

Megha Sharma

2013-08-01

100

Transient hypertrophic pyloric stenosis due to prostoglandin infusion.  

Science.gov (United States)

Prostaglandin E1 (PGE1) is widely used in ductus-dependant congenital heart disease to maintain the patency of ductus. Hypertrophic pyloric stenosis (HPS) due to gastric mucosal proliferation is a rare complication of prolonged PGE infusion. A male newborn who developed HPS during PGE1 infusion is presented to discuss the clinical features and treatment modalities of PGE-related transient HPS. The boy was 2500?g and born at 35 weeks of gestation from a 23-year-old mother. He was admitted to neonatal intensive care with breathing difficulty and cyanosis. His echocardiography revealed pulmonary atresia, ventricular septal defect and major aorta-pulmonary collateral (MAPCA). PGE infusion with a dose of 0.05?mcg?kg(-1) was initiated. At the 8th day of infusion, he developed non-billous vomiting. Ultrasonographic evaluation revealed 1.9?cm length of pyloric channel and 0.5?cm of wall thickness on 11th day and diagnosed as HPS. On 42th postnatal day, he underwent MAPCA closure, right modified Blalock-Taussi shunt and repair of pulmonary artery bifurcation with bovine patch. PGE infusion was stopped and enteral nutrition was started on 8th postoperative day. Control ultrasonography on 12th postoperative day revealed normal pyloric channel length (0.9?cm) and wall thickness (0.3?cm). Prolonged use of PGE infusion in neonates with congenital heart disease may cause transient HPS. The clinical and radiological features of HPS relieves after stopping PGE infusion. It should be kept in mind that HPS due to PGE infusion can be transient and pyloromyotomy should be kept for patients with persistent findings. PMID:25263728

Soyer, T; Yalcin, S; Bozkaya, D; Yi?it, S; Tanyel, F C

2014-10-01

 
 
 
 
101

Parathyroid scanning with 75Se selenomethionine after EDTA-infusion  

International Nuclear Information System (INIS)

In four patients with primary hyperparathyroidism, of which three had already received surgery, hyperfunctioning parathyroid tissue was localised by parathyroid 75Se Selenomethionine scintiscanning after EDTA-infusion. In one patient the same result could be achieved without EDTA. It was suggested that parathyroid 75Se Selenomethionine scanning after EDTA-infusion could be a useful tool in patients with primary hyperparathyroidism, especially in cases in which surgery had been unsuccessful. (author)

102

[Behavioural impairments and hallucinations after consumption of boldo leaf infusions].  

Science.gov (United States)

We report a case of behavioural impairments with hallucinations in a twelve-year-old girl, after consumption of boldo leaf infusions. The main alkaloid of boldo, named boldine, is very likely responsible for temporary neuropsychiatric disturbances present in the patient. The emergence of behavioural problems and hallucinations without any obvious cause, should lead to search for consumption of boldo leaf infusion ("tisanes"). This consumption must be avoided in children. PMID:25230279

Chaboussant, Pierre-Jacques; Gagez, Anne-Laure; Graber, Marianne; Zhao, Jean-Michel; Chavant, François; Perault-Pochat, Marie-Christine; Graber, Denis

2014-01-01

103

Evaluation of maternal infusion therapy during pregnancy for fetal development  

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The aim of this project was to study the possible association between maternal infusion treatments during pregnancy and variables of fetal development as well as the occurrence of congenital abnormalities (CA) in a case-control design. The large population-based data set of the Hungarian Case?Control Surveillance of Congenital Abnormalities (HCCSCA) was evaluated based on the medically recorded infusion treatment during pregnancy. Of 22,843 case pregnant women who had newborns or fetuses wi...

Petik, Do?ra; Puho?, Erzse?bet; Czeizel, Andrew E.

2005-01-01

104

Isolation and characterization of polysaccharides from Fraxinus angustifolia infusions  

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In folk medicine there is a great variety of plants that are used for as infusions, such as Camellia sinensis and Matricaria recutita. Despite the reported biological activities and health benefits of these infusions [1,2], most of the knowledge achieved so far is based on folk tradition passed over several generations, without a sound scientific basis. In Trás-os-Montes region, the dried leaves of the narrow-leafed ash “freixo” (Fraxinus angustifolia) are used for medicin...

Martins, Vitor Manuel Ramalheira; Francisco, Vera; Cruz, Maria T.; Coimbra, Manuel A.

2012-01-01

105

Concomitant continuous infusion chemotherapy and radiation  

International Nuclear Information System (INIS)

Attempts to duplicate the cytotoxic effect of oxygen on radioresistant tissues spurred a search by radiation oncologists for other radiosensitizing techniques. This led to large-scale investigations using neutrons and other heavy particle radiations, hyperthermia, altered fractionation schedules, and the systemic use of the halogenated pyrimidines and the electron-affinic compounds. Unfortunately, the promise that the nitroimidazole compounds would selectively sensitize the radioresistant tumor cells and prove to be an effective systemic agent has not been borne out in clinical trials thus far. Existing pharmokinetic and cytokinetic studies have suggested that continuous infusion chemotherapy given concomitantly (CCIC) with irradiation (RT) acts synergistically, resulting in a significant increase in tumor cell killing. These observations have been supported by clinical research studies treating certain epithelial cancers that have resulted in considerably higher locoregional control rates and improved survival. Although initially used in treatment of only advanced or inoperable epithelial carcinomas, CCIC and RT are now being employed in the treatment of lower staged cancers as an organ-sparing procedure. Carcinoma of the anus treated by anteroposterior (AP) resection alone have reported 5-year survival rates of 30% to 60%. CCIC and RT using 5-fluorouracil (5-FU) and mitomycin C have achieved a local control rate of 90% to 100% and a 5-year survival rate of 80% to 86% with sphincter preservation in 90% of these cases. The 5-year survival rate in advanced urinary bladder carcinoma is 25% to 30% for either radiation or surgery and 42% when combined in a preoperative radiation schedule. Using 5-FU CCIC and RT, the local control rate of transitional cell carcinoma of the bladder has been 71% to 86% with a 5-year survival of 62%. 102 references

106

Lipolytic response to glucose infusion in human subjects  

International Nuclear Information System (INIS)

The authors have determined the effect of various rates of glucose infusion on the rates of release of glycerol (R/sub a/ glycerol), free fatty acids (R/sub a/ FFA), and on energy metabolism in normal human volunteers. Plasma kinetics were determined with use of the stable isotopic tracers D-5-glycerol and [1-13C]palmitate, and energy metabolism was determined by indirect calorimetry. The effect of glucose infusion on R/sub a/ glycerol and R/sub a/ FFA was dose-dependent. At 4 mg x kg-1 x min-1, both R/sub a/ glycerol and R/sub a/ FFA were suppressed; at 8 mg x kg-1 x min-1, R/sub a/ FFA was even more depressed, but R/sub a/ glycerol was similar to the value during the 4 mg x kg-1 x min-1 infusion. At all infusion rates tested, the amount of potential energy available from the sum of the glucose infusion and endogenously mobilized fat was always greater than when no glucose was infused. Glucose decreased fat mobilization by both inhibiting lipolysis and stimulating reesterification, thus causing a significant increase in triglyceride-fatty acid substrate cycling within the adipose tissue. Plasma insulin was determined by radioimmunoassay

107

Effects of adenosine infusion into renal interstitium on renal hemodynamics.  

Science.gov (United States)

This study was designed to investigate the hemodynamic effects of exogenous adenosine in the interstitium of the rat kidney. Adenosine or its analogues were infused into the renal interstitium by means of chronically implanted capsules. Infusion of adenosine (bolus 0.5 mumol plus 0.1 mumol/min) decreased glomerular filtration rate (GFR) from 0.81 +/- 0.06 (mean +/- SE) to 0.37 +/- 0.06 ml/min while having no effect on renal blood flow (RBF). The metabolically stable analogue, 2-chloradenosine (2-ClAdo), (bolus 10 nmol plus 2 nmol/min) decreased GFR from 0.73 +/- 0.07 to 0.21 +/- 0.06 ml/min. Interstitial infusion of theophylline, an adenosine receptor antagonist, completely abolished the effects of adenosine and 2-ClAdo on GFR. The distribution of adenosine, when infused into the renal interstitium, was determined using radiolabeled 5'-(N-ethyl)-carboxamidoadenosine (NECA), a metabolically stable adenosine agonist. After continuous infusion, [3H]NECA was distributed throughout the kidney. The effects of NECA to reduce GFR were similar to those of adenosine and 2-ClAdo. We conclude that increased levels of adenosine in the renal interstitium markedly decrease GFR without affecting RBF in steady-state conditions. The marked effects of adenosine agonists during their infusion into the renal interstitium and the complete blockade of these effects by theophylline suggest an extracellular action of adenosine. PMID:3565578

Pawlowska, D; Granger, J P; Knox, F G

1987-04-01

108

Tracer studies with aortic infusion result in improper tracer distribution  

International Nuclear Information System (INIS)

It has been suggested that lactate turnover can be accurately assessed by infusing radioactive lactate tracer into the aorta and sampling blood in the vena cava. However, there may be streaming of newly infused tracer in the aorta, resulting in a nonuniform arterial specific activity (SA). Furthermore vena caval blood may not be representative of mixed venous blood. The authors examined this problem in 7 anesthetized dogs with sampling catheters in the pulmonary (PA), carotid (CA), and femoral (FA) arteries, and the superior (SVC) and inferior (IVC) vena cavi. [1-14C]lactate was continuously infused into the left ventricle through a catheter introduced through the femoral artery. The same SA (dpm/?mol) was found in the CA and FA, indicating adequate mixing of newly infused tracer with trace. Three dogs showed differences between SVC, IVC and PA, suggesting a mixed venous sample can not be obtained from the VC. When the catheter was moved into the aorta, wide differences in SA appeared between the CA and FA, clearly reflecting streaming of tracer. These differences also appeared in the SVC and IVC. In conclusion, adequate mixing does not occur between tracer and trace in arterial blood with aortic infusion. Further, VC sampling will not give a consistent mixed venous SA. Therefore, for practical reasons, aortic tracer infusion with vena caval sampling will lead to erroneous turnover values

109

Prepreg and infusion processes for modern wind turbine blades  

Energy Technology Data Exchange (ETDEWEB)

The different elements of wind turbine blades have been analyzed for their main function, performance requirements and drivers. Key drivers can be simplified to either performance or cost. The use of prepreg and infusion to make these blade elements has then been compared and shows, from a comparison of test laminates, that prepreg typically delivers higher mechanical performance on both glass and carbon. One of the main process differences, cure temperature, has been overcome with the introduction of M79 which cures at 70 deg. - 80 deg. C. M79 combines this low cure temperature with a much lower reaction enthalpy allowing shorter cure cycles. This means that prepregs can now be cured in the same molds, at the same temperatures and with the same foam as used in a conventional infusion process. Although prepreg and infusion are usually used separately for making blade elements, they may also be used in combination: co-infused and co-cured using prepregs for the hard to infuse unidirectional load-carrying elements and infusion for the other elements. This can thus simplify the production process. The conclusion is that unidirectional prepregs are ideally suited for the performance driven parts of the blade such as in load carrying elements. (Author)

Shennan, C. [Hexcel, Cambridge (United Kingdom)

2013-09-01

110

Electro-osmotic infusion for joule heating soil remediation techniques  

Science.gov (United States)

Electro-osmotic infusion of ground water or chemically tailored electrolyte is used to enhance, maintain, or recondition electrical conductivity for the joule heating remediation technique. Induced flows can be used to infuse electrolyte with enhanced ionic conductivity into the vicinity of the electrodes, maintain the local saturation of near-electrode regions and resaturate a partially dried out zone with groundwater. Electro-osmotic infusion can also tailor the conductivity throughout the target layer by infusing chemically modified and/or heated electrolyte to improve conductivity contrast of the interior. Periodic polarity reversals will prevent large pH changes at the electrodes. Electro-osmotic infusion can be used to condition the electrical conductivity of the soil, particularly low permeability soil, before and during the heating operation. Electro-osmotic infusion is carried out by locating one or more electrodes adjacent the heating electrodes and applying a dc potential between two or more electrodes. Depending on the polarities of the electrodes, the induced flow will be toward the heating electrodes or away from the heating electrodes. In addition, electrodes carrying a dc potential may be located throughout the target area to tailor the conductivity of the target area.

Carrigan, Charles R. (Tracy, CA); Nitao, John J. (Castro Valley, CA)

1999-01-01

111

Investigation of the volatile fraction of rosemary infusion extracts.  

Science.gov (United States)

The relative proportions of chemical classes (hydrocarbons, oxides, alcohols, ketones, esters) in the essential oil of rosemary (Rosmarinus officinalis L., Lamicaeae) and in the volatile fraction of the infusion extracts were examined and showed remarkable differences.The volatile compounds of the infusion were isolated by two different methods, hydrodistillation and solid phase extraction (SPE). The main constituents of the volatile fraction of the infusion were (hydrodistillation/SPE): 1,8-cineole (42.4%/44.7%), camphor (31.4%/31.8%), Î-terpineol (8.6%/8.1%) and borneol (8.3%/7.8%). The qualitative and quantitative composition of the volatile compounds of the infusion was compared to the essential oil isolated by hydrodistillation directly from the leaves. The major constituents of the essential oil of the leaves were 1,8-cineole (41.6%), camphor (17.0%), Î-pinene (9.9%), Î-terpineol (4.9%) and borneol (4.8%). Comparison of the total essential oil yield quantified by hydrodistillation of the infusion (0.36% v/w) with the essential oil yield of the leaves (1.84% v/w) revealed that only 19.6% of the initial oil could be extracted by infusion. PMID:21179360

Tschiggerl, Christine; Bucar, Franz

2010-01-01

112

Continuous intravenous infusions of bromodeoxyuridine as a clinical radiosensitizer  

International Nuclear Information System (INIS)

Twelve patients were treated with continuous intravenous (24-hour) infusions of bromodeoxyuridine (BUdR) at 650 or 1000 mg/m2/d for up to two weeks. Myelosuppression, especially thrombocytopenia, was the major systemic toxicity and limited the infusion period to nine to 14 days. However, bone marrow recovery occurred within seven to ten days, allowing for a second infusion in most patients. Local toxicity (within the radiation field) was minimal, with the exception of one of four patients, who underwent abdominal irradiation. Pharmacology studies revealed a steady-state arterial plasma level of 6 x 10(-7) mol/L and 1 x 10(-6) mol/L during infusion of 650 and 1000 mg/m2/d, respectively. In vivo BUdR uptake into normal bone marrow was evaluated in two patients by comparison of preinfusion and postinfusion in vitro radiation survival curves of marrow CFUc with enhancement ratios (D0-pre/D0-post) of 1.8 (with 650 mg/m2/d) and 2.5 (with 1000 mg/m2/d). In vivo BUdR incorporation into normal skin and tumor cells using an anti-BUdR monoclonal antibody and immunohistochemistry was demonstrated in biopsies from three patients revealing substantially less cellular incorporation into normal skin (less than 10%) compared with tumor (up to 50% to 70%). The authors conclude that local and systemic toxicity of continuous infusion of BUdR at 1000 mg/m2/d for approximately two weeks is tolerable. The observed normal tissue toxicity is comparable with previous clinical experience with intermittent (12 hours every day for two weeks) infusions of BUdR. Theoretically, a constant infusion should allow for greater incorporation of BUdR into cycling tumor cells and thus, for further enhancement of radiosensitization

113

Physical and chemical stability of cisplatin infusions in PVC containers  

Directory of Open Access Journals (Sweden)

Full Text Available Study objectives: To determine the extended chemical and physical stability of cisplatin infusions in PVC containers at normal in-use concentrations in saline, with and without added electrolyte combinations relevant to clinical practice. Methods: Cisplatin infusions 0.1–0.4 mg/mL were prepared in normal saline, with and without magnesium sulphate and potassium chloride supplements in 500 mL PVC bags, and stored at 25°C protected from light. Chemical stability was assessed by a stability-indicating LC method. Evidence for precipitation was detected by a light-blocking particle count method for sub-visible particles, supported by visual examination. pH and weight changes were also monitored for at least 28 days. Results: Both 0.1 mg/mL and 0.4 mg/mL infusions, with or without the added electrolyte supplements, were chemically stable over 28 days at 25°C. The pH of infusions varied by no more than 0.2 units over this time, there was no visible precipitation, and no significant changes in sub-visual particulate levels or infusion weight. The study was restricted to 28 days because small, visual precipitation was evident in some infusions after 35 days. Conclusion: Cisplatin infusions at concentrations ranging from 0.1–0.4 mg/mL, in 500 mL PVC bags containing either 0.9% sodium chloride or 0.9% sodium chloride + 20 mmoL KCl + 8 mmoL MgSO4 were physically and chemically stable for up to 28 days at 25°C, when protected from light. Extending shelf lives beyond this period is unsafe due to the potential development of precipitates.

Graham Sewell

2010-01-01

114

Effects of adenosine infusion into renal interstitium on renal hemodynamics  

International Nuclear Information System (INIS)

This study was designed to investigate the hemodynamic effects of exogenous adenosine in the interstitium of the rat kidney. Adenosine or its analogues were infused into the renal interstitium by means of chronically implanted capsules. In fusion of adenosine decreased glomerular filtration rate (GFR) from 0.81 +/- 0.06 to 0.37 +/- 0.06 ml/min while having no effect on renal blood flow (RBF). The metabolically stable analogue, 2-chloradenosine (2-ClAdo), decreased GFR from 0.73 +/- 0.07 to 021 +/- 0.06 ml/min. Interstitial infusion of theophylline, an adenosine receptor antagonist, completely abolished the effects of adenosine and 2-ClAdo on GFR. The distribution of adenosine, when infused into the renal interstitium, was determined using radiolabeled 5'-(N-ethyl)-carboxamidoadenosine (NECA), a metabolically stable adenosine agonist. After continuous infusion, [3H]NECA was distributed throughout the kidney. The effects of NECA to reduce GFR were similar to those of adenosine and 2-ClAdo. They conclude that increased levels of adenosine in the renal interstitium markedly decrease GFR without affecting RBF in steady-state conditions. The marked effects of adenosine agonists during their infusion into the renal interstitium and the complete blockade of these effects by theophylline suggest an extracellular action of adenosine

115

Resin infusion of large composite structures modeling and manufacturing process  

Energy Technology Data Exchange (ETDEWEB)

The resin infusion processes resin transfer molding (RTM), resin film infusion (RFI) and vacuum assisted resin transfer molding (VARTM) are cost effective techniques for the fabrication of complex shaped composite structures. The dry fibrous preform is placed in the mold, consolidated, resin impregnated and cured in a single step process. The fibrous performs are often constructed near net shape using highly automated textile processes such as knitting, weaving and braiding. In this paper, the infusion processes RTM, RFI and VARTM are discussed along with the advantages of each technique compared with traditional composite fabrication methods such as prepreg tape lay up and autoclave cure. The large number of processing variables and the complex material behavior during infiltration and cure make experimental optimization of the infusion processes costly and inefficient. Numerical models have been developed which can be used to simulate the resin infusion processes. The model formulation and solution procedures for the VARTM process are presented. A VARTM process simulation of a carbon fiber preform was presented to demonstrate the type of information that can be generated by the model and to compare the model predictions with experimental measurements. Overall, the predicted flow front positions, resin pressures and preform thicknesses agree well with the measured values. The results of the simulation show the potential cost and performance benefits that can be realized by using a simulation model as part of the development process. (au)

Loos, A.C. [Michigan State Univ., Dept. of Mechanical Engineering, East Lansing, MI (United States)

2006-07-01

116

Continuous versus bolus infusion of terlipressin in ovine endotoxemia.  

Science.gov (United States)

In patients with sepsis, hemodynamic support is often complicated by a tachyphylaxis against conventional vasopressor agents. Bolus infusion of terlipressin, a vasopressin analog, has been reported to increase mean arterial pressure in patients with catecholamine-resistant septic shock. However, bolus infusion of terlipressin may be associated with severe side effects, including pulmonary vasoconstriction and impairment of oxygen delivery. We hypothesized that continuous low-dose infusion of terlipressin may reverse sepsis-related systemic arterial hypotension with reduced side effects as compared with the traditional concept of bolus administration. Twenty-seven adult sheep were instrumented for chronic study. After a baseline measurement, Salmonella typhosa endotoxin (10 ng.kg-1.min-1) was continuously administered for the next 40 h. After 16 h of endotoxemia, the surviving sheep (n = 24) were randomly assigned to be treated with either a continuous infusion of terlipressin (2 mg for 24 h), bolus injections of terlipressin (1 mg every 6 h), or placebo (normal saline; each n = 8). Continuous infusion of terlipressin permanently reversed endotoxin-induced systemic arterial hypotension (P hypotension related to sepsis and systemic inflammatory response syndrome. PMID:17589382

Lange, Matthias; Morelli, Andrea; Ertmer, Christian; Koehler, Gabriele; Bröking, Katrin; Hucklenbruch, Christoph; Bone, Hans-Georg; Van Aken, Hugo; Traber, Daniel L; Westphal, Martin

2007-11-01

117

Propofol infusion syndrome and Brugada syndrome electrocardiographic phenocopy.  

Science.gov (United States)

This anesthetic drug may cause a rare condition named propofol infusion syndrome, characterized by unexplained lactic acidosis, lipemia, rhabdomyolysis, cardiovascular collapse and Brugada-like electrocardiographic pattern or Brugada electrocardiographic phenocopy changes following high-dose propofol infusion over prolonged periods of time. Several articles have contributed to our understanding of the cause of the syndrome, and the growing number of case reports has made it possible to identify several risk factors. Uncertainty remains as to whether a genetic susceptibility exists. The favorable recovery profile associated with propofol offers advantages over traditional anesthetics in clinical situations in which rapid recovery is important. Propofol is a safe anesthetic agent, but propofol infusion syndrome is a rare lethal complication. PMID:20544610

Riera, Andrés Ricardo Pérez; Uchida, Augusto Hiroshi; Schapachnik, Edgardo; Dubner, Sergio; Filho, Celso Ferreira; Ferreira, Celso

2010-01-01

118

Determination of selected microelements in polish herbs and their infusions  

International Nuclear Information System (INIS)

Ba, Cd, Cr, Cu, Fe, Ni, Pb and Zn were determined in birch leaves (Folium Betulae), dandelion roots (Radix Taraxacae), hawthorn blossom (Inflorescentia Crataegi) and their infusions by graphite furnace atomic absorption spectrometry (GFAAS) after microwave digestion of plant samples. Infusions were made from herbs according to prescription for patients, provided by the producer of medicine on the package. The results obtained were compared with daily requirements for each element. Results show high content of cadmium in the medicinal plants analyzed. The highest level in infusions was observed for Ni and Zn (over 90% of the total element concentration for Ni and in most cases over 50% for Zn), and the lowest for Cd and Pb. The calculated daily intake of majority of the analyzed elements was very low (under 1% of daily requirements)

119

Composition of antioxidants and amino acids in Stevia leaf infusions.  

Science.gov (United States)

Stevia, a non-caloric natural sweetener with beneficial properties and considerable antioxidants and amino acids, is increasingly consumed as an infusion. This work evaluates the influence of the conditions (temperature: 50, 70 or 90 °C and time: 1, 5, 20 or 40 min) applied to obtain Stevia infusions, on antioxidants (total phenols, flavonoids and antioxidant activity) and amino acids. The total concentration of the eleven amino acids found was 11.70 mg/g in dried leaves and from 6.84 to 9.11 mg/g per gram of Stevia in infusions. However, infusions showed higher levels of certain amino acids (alanine, asparagine, leucine and proline), and greater values of the three antioxidant parameters in comparison with dry leaves. Temperature had more influence (minimum values at 50 °C and maximum at 90 °C) than time in the case of antioxidants. At 90 °C there were no important increases in the extraction of antioxidant compounds after 5 min; each gram of Stevia had 117 mg trolox (total antioxidant activity), 90 mg gallic acid (total phenols) and 56 mg catechin equivalents (flavonoids). Varying the temperature and time conditions no notable differences were observed in the concentrations of the majority of amino acids. However, the infusion treatment at 90 °C for 5 min was the best, as it gave the highest yield of 8 of the 11 amino acids. Therefore, with respect to the compounds analyzed in this study, the best way to obtain Stevia leaf infusions is the same as the domestic process, almost boiling water for a short time. PMID:24293005

Periche, Angela; Koutsidis, Georgios; Escriche, Isabel

2014-03-01

120

Développement de nouveaux matériaux pour l'infusion de composites  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Ce travail de thèse vise à adapter un système polymère au procédé d’élaboration par infusion d’une structure en matériaux composite pour fuselage d’avion. Ce système doit répondre à certaines exigences de viscosité, de température d’infusion, de stockage mais également de prix. La méthodologie mise en place consiste à s’approprier le procédé de mise en oeuvre afin de valider le choix des résines, de les caractériser à l’état initial et enfin d’étudier leur...

Poussines, Laurence

2012-01-01

 
 
 
 
121

Effect of Insulin Infusion on Liver Protein Synthesis during Hemodialysis  

DEFF Research Database (Denmark)

Background Hemodialysis (HD) is a catabolic procedure that may contribute to the high frequency of protein-energy wasting among patients receiving maintenance HD. The present study investigated the additional effect of glucose and glucose-insulin infusion on liver protein synthesis during HD compared with a meal alone. Methods In a randomized cross-over study with three arms, 11 non-diabetic HD patients were assigned to receive a conventional HD session with either: • no treatment (NT) • IV infusion of glucose (G) • IV infusion of glucose-insulin (GI) During infusions blood glucose levels were maintained at 8.0-10.0 mmol/L by additional glucose infusion. Glucose and glucose-insulin infusions were commenced 2 h prior to HD and continued throughout the HD session. Fasting blood samples were collected at baseline before infusion and followed by the only meal allowed during the study. Results Blood glucose and insulin: The change in blood glucose differed significantly from baseline (-120 min) to end of HD (240 min) between the NT group and the G group (p=0.002); there was no significant difference in the change between the NT group and the GI group (p=0.06), or between the G group and the GI group (p=0.15). Fibrinogen and albumin: There was an overall increase in serum albumin (38.8±2.1 to 40.4±2.5 g/L, p<0.0001) and in serum fibrinogen (11.7±1.7 to 12.8±1.8 µmol/L, p<0.0001) from HD start (0 min) to 2 h post HD (360 min), but no significant difference in the change in either albumin (p=0.12) or fibrinogen (p=0.12) between the groups. IGFBP-1: During the first 4 h after baseline (-120 min) we observed an overall decrease in serum IGF-binding protein 1 (IGFBP-1) (from 267±147 to 140±84 µg/L, p<0.0001), but no difference in the change between groups (p=0.41). However, from 4 h after baseline to the end of the study there was a significant difference in the change in serum IGFBP-1 between the groups (p=0.003) with a significant increase in serum IGFBP-1 in the NT group (p<0.0001), but not in the G group or GI group (p=0.50 and p=0.07, respectively). Conclusions Compared with a meal neither glucose nor glucose-insulin infusion appear to have any extra effects on liver protein synthesis during HD.

Reinhard, Mark; Frystyk, Jan

122

Resin film infusion mold tooling and molding method  

Science.gov (United States)

A mold apparatus and method for resin film infusion molding including an outer mold tool having a facing sheet adapted to support a resin film and preform assembly. The facing sheet includes attachment features extending therefrom. An inner mold tool is positioned on the facing sheet to enclose the resin film and preform assembly for resin film infusion molding. The inner mold tool includes a plurality of mandrels positioned for engagement with the resin film and preform assembly. Each mandrel includes a slot formed therein. A plurality of locating bars cooperate with the slots and with the attachment features for locating the mandrels longitudinally on the outer mold tool.

Burgess, Roger (Inventor); Grossheim, Brian (Inventor); Mouradian, Karbis (Inventor); Thrash, Patrick J. (Inventor)

1999-01-01

123

Physical and chemical stability of cisplatin infusions in PVC containers  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Study objectives: To determine the extended chemical and physical stability of cisplatin infusions in PVC containers at normal in-use concentrations in saline, with and without added electrolyte combinations relevant to clinical practice. Methods: Cisplatin infusions 0.1–0.4 mg/mL were prepared in normal saline, with and without magnesium sulphate and potassium chloride supplements in 500 mL PVC bags, and stored at 25°C protected from light. Chemical stability was assessed by a stability-i...

Graham Sewell

2010-01-01

124

Hypovolaemia after glucose-insulin infusions in volunteers  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Abstract High-dose intravenous infusion of glucose 5% promotes rebound hypoglycaemia and hypovolaemia in healthy volunteers. To study whether such effects occur in response to glucose-insulin, 12 healthy firemen (mean age 39 years) received 3 infusions over 1-2 hours that contained 20 ml/kg of glucose 2.5%, 5 ml/kg of glucose 10% with rapid-acting insulin 0.05 U/kg, and 4 ml/kg of glucose 50% with 1 U/kg of insulin. The plasma glucose concentration and plasma dilution were compared...

2008-01-01

125

Cesarean Sections  

Science.gov (United States)

... babies in the United States are delivered via cesarean section (C-section). Even if you're envisioning ... have a successful and safe vaginal birth after cesarean but, in some cases, future births may have ...

126

Demonstration of the dorsal pancreatic artery by CTA to facilitate superselective arterial infusion of stem cells into the pancreas  

International Nuclear Information System (INIS)

Purpose: To investigate the diagnostic performance of 64-section CTA in the detection of dorsal pancreatic artery before interventional therapy for patients with diabetes. Materials and methods: The study was approved by the institutional ethics committee; written informed consent was obtained. Forty-two consecutive patients with diabetes received an experimental treatment of autologous bone marrow-derived stem cell transplantation by means of infusion into the dorsal pancreatic artery. All cases underwent abdominal CTA before angiography of pancreatic arteries in order to locate the origin and course of dorsal pancreatic artery. Angiography of coeliac artery, splenic artery, common hepatic artery and superior mesenteric artery were performed both in CTA and DSA. Superselective catheterization of dorsal pancreatic artery was carried out for the infusion of stem cell. Sensitivity, specificity and accuracy for the detection of dorsal pancreatic artery with CTA were calculated using DSA images as the reference standard. Results: Thirty-five and thirty-six dorsal pancreatic arteries were detected by CTA and DSA respectively. Dorsal pancreatic artery was not visualized in either CTA or DSA in 5 patients. The sensitivity, specificity and accuracy for CTA were 94.4%, 83.3% and 92.9%. Conclusion: 64-section CTA is accurate for the detection of dorsal pancreatic artery. It may be useful for the facilitation of superselective arterial infusion of stem cells to pancreas.nfusion of stem cells to pancreas.

127

Cesarean Section  

Science.gov (United States)

A Cesarean section (C-section) is surgery to deliver a baby. The baby is taken out through the mother's abdomen. In the United States, ... four women have their babies this way. Most C-sections are done when unexpected problems happen during delivery. ...

128

[Diuretic activity of the infusion of flowers from Lavandula officinalis].  

Science.gov (United States)

The diuretic activity of an infusion of Lavandula officinalis was studied in the Wistar rat. Thus, the kinetics of hydroelectrolytic elimination in response to the oral administration of an infusion of pharmaceutical lavender flowers were measured in the rats. Experiments were completed under similar conditions using a synthetic pharmacological diuretic, Diamox. The aqueous extract of this aromatic plant accelerated the elimination of the water overload. At the peak of the diuretic response, urinary osmolarity was significantly less than that of controls (111+/-14 vs. 195+/-11 mosmol x kg(-1)). Sodium excretion was moderate following administration of the infusion when compared to the synthetic diuretic. The stability of the aldosterone concentrations in the plasma and the absence of correlation with plasma sodium concentrations, coupled with the observed clearance of the free water (0.055+/-0.007 vs. 0.045+/-0.012 mL x min(-1)) show that the increase in diuresis and the moderate increase in sodium excretion are of tubular origin. The result of the phytochemical analysis of hexane extracts in the infusion and in urine indicated that four or five chemical factors may be involved in the diuretic effect of lavender. PMID:12014366

Elhajili, M; Baddouri, K; Elkabbaj, S; Meiouat, F; Settaf, A

2001-01-01

129

Melissa officinalis and Passiflora caerulea infusion as physiological stress decreaser.  

Science.gov (United States)

The objective of this study was to determine the effect of a Melissa officinalis and Passiflora caerulea infusion on the severity of physiological chronic stress induced by movement restriction in CF-1 mice. 40 CF-1 male mice, six weeks of age, were divided into 4 groups (n = 10 for each group): (1) Group RS/MP received two treatments, induced stress through movement restriction and a infusion of Melissa officinalis and Passiflora caerulea in a dose of 200 mg/kg, (2) RS group with induced stress using movement restriction, (3) MP group, which received only a infusion, and (4) a CONTROL group that received no treatment. The severity of the stress was obtained by analysis of the physical parameters of body weight, thymus and spleen, and associated biomarkers with stress, corticosterone, and glucose. Animals that consumed Melissa officinalis and Passiflora caerulea infusion had lower plasma corticosterone levels (Student's t test, Welch, p = 0.05), which is the most important biomarker associated with physiological stress, demonstrating a phytotherapy effect. PMID:23844268

Feliú-Hemmelmann, Karina; Monsalve, Francisco; Rivera, César

2013-01-01

130

Development of a Multidisciplinary Middle School Mathematics Infusion Model  

Science.gov (United States)

The National Science Foundation (NSF) funded project "Mathematics, Science, and Technology Partnership" (MSTP) developed a multidisciplinary instructional model for connecting mathematics to science, technology and engineering content areas at the middle school level. Specifically, the model infused mathematics into middle school curriculum…

Russo, Maria; Hecht, Deborah; Burghardt, M. David; Hacker, Michael; Saxman, Laura

2011-01-01

131

Treatment of bladder carcinoma with concomitant infusion chemotherapy and irradiation  

International Nuclear Information System (INIS)

In an attempt to increase tumor clearance and bladder preservation without increased morbidity, a pilot study using irradiation and concomitant continuous 5-FU infusion, and Mitomycin C as IV bolus in the treatment of invasive high grade bladder carcinomas was started at Downstate Medical Center. This report shows the preliminary results regarding tumor response, survival, and morbidity of treatment

132

Using Cross-Curricular Ideas to Infuse Paralympic Sport  

Science.gov (United States)

The Paralympic Games are the second largest sport event in the world. They occur two weeks after the Olympic Games in the same geographic location and sport venues. Despite the Paralympic Games' longevity, many Americans do not even know they exist. One way to meaningfully share information about this event with people of all ages is to infuse a…

Tepfer, Amanda T. S.; Lieberman, Lauren J.

2012-01-01

133

[A study of complications of hepatic arterial infusion catheter].  

Science.gov (United States)

We studied complications of the infusion catheter, which were implanted in the hepatic artery under laparotomy, and then connected with an implantable infuser port in patients with hepatocellular carcinoma (n = 32) and metastatic liver tumor (n = 11). Infuse-A-Port catheter was used for 31 cases (A group), and Anthron P-U catheter for 12 cases (B group). In B group, the cannulation method was changed; the catheter was placed in the hepatic artery via the gastroduodenal artery, which was ligated and cut to prevent kinks in the catheter. In the A group, 17 cases (54.8%) showed complications such as dislocation of the catheter tip (7 cases) including penetrating duodenal ulcer (2 cases), arterial occlusion (6 cases), injury of catheter (2 cases) and occlusion of the infuser port (2 cases). One case, however, having a fistula between the hepatic artery and the duodenum, died of sudden massive bleeding. In the B group, 3 cases (25.0%) showed complications such as dislocation of the catheter tip (1 case) and arterial occlusion (2 cases). The catheter in B group lasted longer than that in A group. Thus, our cannulation technique using Anthron P-U catheter may decrease the catheter complications. PMID:1530312

Tsurumi, M; Oka, M; Hazama, S; Yano, K; Uchiyama, T; Suzuki, T

1992-08-01

134

Prostacyclin infusion may prevent secondary damage in pericontusional brain tissue  

DEFF Research Database (Denmark)

Prostacyclin is a potent vasodilator, inhibitor of leukocyte adhesion, and platelet aggregation, and has been suggested as therapy for cerebral ischemia. A case of focal traumatic brain lesion that was monitored using intracerebral microdialysis, and bedside analysis and display is reported here. When biochemical signs of cerebral ischemia progressed, i.v. infusion of prostacyclin was started.

Reinstrup, Peter; Nordström, Carl-Henrik

2011-01-01

135

Arginine infusion increases peripheral plasma somatostatin in man.  

Science.gov (United States)

A somatostatin (SRIF) radioimmunoassay is described, using an antiserum raised in rabbit, reacting more with SRIF-14 than -28. Glass tubes were employed for the assay because our tracer, 125I 1-Tyr-SRIF, was adsorbed to plastic (23% non specific binding). Vycor extraction was used, and following Sephadex G-50 chromatography, the plasma extract showed two forms, coeluting with SRIF-28 and -14. Fifteen healthy subjects, eight women and seven men, 21-39 years old, received an infusion of arginine chloride (2.38 mmol/kg) for 20 min, or saline. An immediate rise in plasma SRIF from the mean basal level at 2 min was shown. Maximal value was 24.0 +/- 3.0 pmol/l (P less than 0.01) after 10 min followed by a rapid descent towards the basal level after the infusion. A temporal relationship was observed between the SRIF, insulin and glucagon responses following arginine infusion, while the GH levels increased only after the SRIF levels had declined, indicating an inhibition of GH. This is further supported by the high degree of correlation (r = 0.87) between SRIF- and GH increments. It is suggested that plasma SRIF measurement during arginine infusion gives an estimate of the pancreatic SRIF releasing capacity. PMID:6148165

Skare, S; Hanssen, K F; Kriz, V; Torjesen, P A

1984-09-01

136

Infusing Adlerian Theory into an Introductory Marriage and Family Course.  

Science.gov (United States)

Important contributions of "Individual Psychology" to marriage and family counseling are examined. Through "open forum family counseling," a framework is provided for infusing these ideas into training family practitioners. Key concepts, assessment techniques, strategies to help individuals understand their own family of origin, role plays, and…

LaFountain, Rebecca M.; Mustaine, Beverly L.

1998-01-01

137

Simulation par éléments finis des procédés par infusion de résine  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Cet article expose un modèle numérique permettant de simuler par éléments finis les procédés par infusion de résine au travers de renforts fibreux. Ce modèle nécessite le couplage entre un écoulement dans un milieu poreux (Darcy), non poreux (Stokes) et la déformation élastique de préformes. Une méthode level-set permet de décrire les interfaces fixes ou mobiles de couplage.

Pacquaut, G.; Bruchon, J.; Moulin, N.; Drapier, S.; Abou Orm, L.

2011-01-01

138

Residues and contaminants in tea and tea infusions: a review.  

Science.gov (United States)

Consumers are very aware of contaminants that could pose potential health hazards. Most people drink tea as an infusion (adding hot water); however, in some countries, including India, China and Egypt, tea is drunk as a decoction (tea and water are boiled together). An infusion usually brings the soluble ingredients into solution, whereas a decoction brings all soluble and non-soluble constituents together. Therefore, a cup of tea may contain various kinds of contaminants. This review focuses on green and black tea because they are most commonly consumed. The target was to examine the transfer rate of contaminants - pesticides, environmental pollutants, mycotoxins, microorganisms, toxic heavy metals, radioactive isotopes (radionuclides) and plant growth regulators - from tea to infusion/brewing, factors contributing to the transfer potential and contaminants degradation, and residues in or on the spent leaves. It is concluded that most contaminants leaching into tea infusion are not detected or are detected at a level lower than the regulatory limits. However, the traditional practice of over-boiling tea leaves should be discouraged as there may be a chance for more transfer of contaminants from the tea to the brew. PMID:25164107

Abd El-Aty, A M; Choi, Jeong-Heui; Rahman, Md Musfiqur; Kim, Sung-Woo; Tosun, Alev; Shim, Jae-Han

2014-11-01

139

21 CFR 526.464d - Cloxacillin sodium for intramammary infusion.  

Science.gov (United States)

...2010-04-01 false Cloxacillin sodium for intramammary infusion... § 526.464d Cloxacillin sodium for intramammary infusion...milliliter contains cloxacillin sodium equivalent 20.0 milligrams...as early as possible after detection. Treatment...

2010-04-01

140

21 CFR 526.464c - Cloxacillin sodium for intramammary infusion, sterile.  

Science.gov (United States)

...2010-04-01 false Cloxacillin sodium for intramammary infusion... § 526.464c Cloxacillin sodium for intramammary infusion...milliliter contains cloxacillin sodium equivalent to 20.0 milligrams...as early as possible after detection. Treatment...

2010-04-01

 
 
 
 
141

21 CFR 526.464b - Cloxacillin benzathine for intramammary infusion, sterile.  

Science.gov (United States)

...false Cloxacillin benzathine for intramammary infusion, sterile. 526.464b...FEEDS, AND RELATED PRODUCTS INTRAMAMMARY DOSAGE FORMS § 526.464b Cloxacillin benzathine for intramammary infusion, sterile. (a)...

2010-04-01

142

21 CFR 526.464c - Cloxacillin sodium for intramammary infusion, sterile.  

Science.gov (United States)

... false Cloxacillin sodium for intramammary infusion, sterile. 526.464c...DRUGS, FEEDS, AND RELATED PRODUCTS INTRAMAMMARY DOSAGE FORMS § 526.464c Cloxacillin sodium for intramammary infusion, sterile. (a)...

2010-04-01

143

Impact of infusion speed on the safety and effectiveness of prothrombin complex concentrate  

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Abstract Prothrombin complex concentrate (PCC) infusion is preferred for emergency reversal of coumarin therapy. Rapid infusion can potentially save crucial time; however, the possible impact of high infusion speed on PCC safety and effectiveness has not been delineated. In a prospective multinational clinical trial with 43 patients receiving PCC (Beriplex® P/N) for emergency reversal of coumarin therapy, infusion speeds were selected by the investigators. In a two-phase statistic...

2009-01-01

144

Using miniature osmotic infusion pumps to maintain tritiated thymidine exposure to cells in culture  

International Nuclear Information System (INIS)

To provide a constant level of tracer doses of tritiated thymidine to cultured cells during continuous infusion, miniature osmotic infusion pumps were used to provide replacement thymidine. By determining the loss of isotope from the media during nonreplacement, the rate of constant infusion replacement to maintain thymidine levels was calculated. The replacement rates were similar for the three cell lines examined and allowed a standard osmotic pump infusion

145

Mineral Analysis the Infusion of Black Tea Samples by Atomic Absorption Spectrometry  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Tea infusion is one of the most popular drinks around the world. Since tea infusion is known to contain several essential nutrients, it is considered a healthy beverage. In this study eight different Iranian brands of tea infusion and eleven brands imported tea infusion samples from another country for Cu, Zn, Mn and Al were determined by flame atomic absorption spectrometry after wet digestion. The results of analysis showed that the extraction rates of minerals from dry black tea to infusio...

Lahiji N.; Tadayon F.; Tamiji F.; Lahiji A. H.

2013-01-01

146

Infusion pressure and pain during microneedle injection into skin of human subjects  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Infusion into skin using hollow microneedles offers an attractive alternative to hypodermic needle injections. However, the fluid mechanics and pain associated with injection into skin using a microneedle have not been studied in detail before. Here, we report on the effect of microneedle insertion depth into skin, partial needle retraction, fluid infusion flow rate and the co-administration of hyaluronidase on infusion pressure during microneedle-based saline infusion, as well as on associat...

Gupta, Jyoti; Park, Sohyun; Bondy, Brian; Felner, Eric I.; Prausnitz, Mark R.

2011-01-01

147

Glucose Infusion into Exercising Dogs after Confinement: Rectal and Active Muscle Temperatures  

Science.gov (United States)

Intravenous glucose infusion into ambulatory dogs results in attenuation of exercise-induced increase of both rectal and thigh muscle temperatures. That glucose (Glu) infusion attenuates excessive increase in body temperature from restricted activity during confinement deconditioning. Intravenous glucose infusion attenuates the rise in exercise core temperature in deconditioned dogs by a yet undefined mechanism.

Greenleaf, J. E.; Kruk, B.; Nazar, K.; Falecka-Wieczorek, I.; Kaciuba-Uscilko, H.

1995-01-01

148

Design of a safer approach to intravenous drug infusions: failure mode effects analysis  

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Objectives: A set of standard processes was developed for delivering continuous drug infusions in order to improve (1) patient safety; (2) efficiency in staff workflow; (3) hemodynamic stability during infusion changes, and (4) efficient use of resources. Failure modes effects analysis (FMEA) was used to examine the impact of process changes on the reliability of delivering drug infusions.

Apkon, M.; Leonard, J.; Probst, L.; Delizio, L.; Vitale, R.

2004-01-01

149

Effect of glucose-insulin-potassium infusion on thallium myocardial clearance  

International Nuclear Information System (INIS)

earance after the saline infusion. Heart rate, aortic and left atrial pressure, sonomicrometer-measured transmural myocardial wall thickness, microsphere-determined myocardial blood flow, and blood glucose and potassium concentrations did not change significantly during GIK or saline infusions. Thus, GIK infusion appears to increase net 201Tl clearance from myocardial zones with and without initial 201Tl loading

150

Haemolysis following rapid experimental red blood cell transfusion--an evaluation of two infusion pumps  

DEFF Research Database (Denmark)

The vast majority of infusion pumps used for rapid transfusion of large amounts of blood have never been properly examined regarding their influence on the quality of the red blood cells (RBCs) infused. In this study, we evaluated the effect of two different infusion pumps on the degree of RBC destruction following rapid experimental blood transfusion.

Hansen, Tom Giedsing; SprogØe-Jakobsen, U

1998-01-01

151

Mannitol infusion immediately after reperfusion suppresses the development of focal cortical infarction after temporary cerebral ischemia in gerbils  

Science.gov (United States)

Previously we found that, after temporary cerebral ischemia, microvasculogenic secondary focal cerebral cortical ischemia occurred, caused by microvascular obstruction due to compression by swollen astrocytic end-feet, resulting in focal infarction. Herein, we examined whether mannitol infusion immediately after restoration of blood flow could protect the cerebral cortex against the development of such an infarction. If so, the infusion of mannitol might improve the results of vascular reperfusion therapy. We selected stroke-positive animals during the first 10?min after left carotid occlusion performed twice with a 5-h interval, and allocated them into four groups: sham-operated control, no-treatment, mannitol-infusion, and saline-infusion groups. Light- and electron-microscopic studies were performed on cerebral cortices of coronal sections prepared at the chiasmatic level, where the focal infarction develops abruptly in the area where disseminated selective neuronal necrosis is maturing. Measurements were performed to determine the following: (A) infarct size in HE-stained specimens from all groups at 72 and 120?h after return of blood flow; (B) number of carbon-black-suspension-perfused microvessels in the control and at 0.5, 3, 5, 8, 12 and 24?h in the no-treatment and mannitol-infusion groups; (C) area of astrocytic end-feet; and (D) number of mitochondria in the astrocytic end-feet in electron microscopic pictures taken at 5?h. The average decimal fraction area ratio of infarct size in the mannitol group was significantly reduced at 72 and 120?h, associated with an increased decimal fraction number ratio of carbon-black-suspension-perfused microvessels at 3, 5 and 8?h, and a marked reduction in the size of the end-feet at 5?h. Mannitol infusion performed immediately after restitution of blood flow following temporary cerebral ischemia remarkably reduced the size of the cerebral cortical focal infarction by decreasing the swelling of the end-feet, thus preventing the microvascular compression and stasis and thereby microvasculogenic secondary focal cerebral ischemia. PMID:24661099

Ito, Umeo; Hakamata, Yoji; Watabe, Kazuhiko; Oyanagi, Kiyomitsu

2014-01-01

152

Liquid Resin Infusion process monitoring with embedded superimposed long period and short period Bragg grating sensor.  

Directory of Open Access Journals (Sweden)

Full Text Available We propose here the monitoring of the Liquid Resin Infusion (LRI process for using a superimposed long period (LPG and short period (FBG Bragg grating sensor. Monitoring of such a process is usually made measuring simultaneously temperature and strain by the use of an electro-optical device (FBG-Thermocouple. It has been shown that an applied solicitation is measured by a wavelength shift with a different sensitivity for LPG and FBG; thus strain and temperature influences can be determined separately by measuring corresponding wavelength shifts. The reported configuration is based on the use of these two Bragg gratings types written in the same fibre section, which allows us to discriminate the contributions of the temperature and strain. The sensor is embedded in a composite specimen manufactured by LRI process for monitoring in real time and simultaneously the applied temperature and strain.

Robert L.

2010-06-01

153

Infusing Disability Sport into the Sport Management Curriculum  

Directory of Open Access Journals (Sweden)

Full Text Available Disability sport is growing around the world with momentum and is described as a “movement” (Bailey, 2008; DePauw & Gavron, 2005. While there are more similarities than differences with sport management for able-bodied athletes and those with disabilities, there are additional needs and considerations for persons with disabilities (DePauw & Gavron, 2005. The noticeable visibility of individuals with disabilities in society, including sport, raises concerns about the degree to which sport management academic programs have modified their curricula to ensure that individuals working in the sport management field are prepared to deal with theuniqueness of disability sport. This paper (a discusses theoretical perspectives toward understanding and thinking about disability, (b explores ways to enhance sport management curricula through infusion of disability sport, (c reflects upon current social practices for curriculum integration of athletes with disabilities in sport, and (d acknowledges infusion of disability sport businesses, organizations and events.

Jimmy Calloway

2012-01-01

154

Rare, potentially fatal, poorly understood propofol infusion syndrome  

Directory of Open Access Journals (Sweden)

Full Text Available We present the case of a 7-year old boy with traumatic brain injury who received propofol during 38 h. Thirty-six hours after cessation of propofol infusion asystole occurred. After immediate mechanical and medical resuscitation, unreactive dilated pupils were observed. The following computed tomography scan revealed a generalized brain edema with transtentorial herniation. Prolonged bradyarrhythmia, rhabdomyolysis, and peracute renal failure were observed. Despite immediate craniectomy, barbiturate treatment, hemofiltration, and recovery of appropriate cardiac function, the patient died four days after discontinuation of propofol. In this case, metabolic acidosis, cardiac failure, rhabdomyolysis, and renal failure are in accordance with the symptoms of propofol infusion syndrome (PRIS, while seizure, brain edema, and transtentorial herniation could be caused by traumatic brain injury. However, it may be assumed that the entire clinical picture was caused by PRIS. This view could be explained by a common loss of function of ryanodine receptors in patients presenting with PRIS.

Albert Urwyler

2012-05-01

155

A Fast Technology Infusion Model for Aerospace Organizations  

Science.gov (United States)

A multi-year Fast Technology Infusion initiative proposes a model for aerospace organizations to improve the cost-effectiveness by which they mature new, in-house developed software and hardware technologies for space mission use. The first year task under the umbrella of this initiative will provide the framework to demonstrate and document the fast infusion process. The viability of this approach will be demonstrated on two technologies developed in prior years with internal Jet Propulsion Laboratory (JPL) funding. One hardware technology and one software technology were selected for maturation within one calendar year or less. The overall objective is to achieve cost and time savings in the qualification of technologies. At the end of the recommended three-year effort, we will have demonstrated for six or more in-house developed technologies a clear path to insertion using a documented process that permits adaptation to a broad range of hardware and software projects.

Shapiro, Andrew A.; Schone, Harald; Brinza, David E.; Garrett, Henry B.; Feather, Martin S.

2006-01-01

156

Smart Infusion Pump: A boon to the Health Care Industry  

Directory of Open Access Journals (Sweden)

Full Text Available Main motive of any hospital or clinic is to provide the best patient care. Patient care can be drastically improved using electronic medical record. An electronic medical record (EMR is a computerized medical record created in an organization that delivers care, such as a hospital or physician's office. The costs of storage media, such as paper and film, per unit of information differ dramatically from that of electronic storage media. When paper records are stored in different locations, collating them to a single location for review by a health care provider is time consuming and complicated, whereas the process can be simplified with electronic records. When treating a patient another major thing is to monitor the drug or fluid administered to the patient. Better and safer drug delivery systems will be the one with automatic or an intelligent infusion pump system. Thus automatic intravenous infusion will efficiently reduce medication and administration error.

K.V. Padmaja#1 , Apoorva M. Kalgal

2013-06-01

157

Anisomycin infusions in the parabrachial nucleus and taste neophobia.  

Science.gov (United States)

To investigate whether de novo protein synthesis in the parabrachial nucleus (PBN) is required for recovery from taste neophobia, anisomycin (a protein synthesis inhibitor) was infused immediately after consumption of a novel saccharin solution (Experiment 1). Unexpectedly, this PBN treatment caused a reduction in saccharin intake. In addition, we found that the anisomycin-induced suppression of tastant intake was attenuated by prior intra-PBN infusions of lidocaine (Experiment 2). This pattern of results raises concerns about using anisomycin to investigate memory consolidation processes in the PBN. Thus, a different manipulation may be needed to examine the nature of the neuroplastic changes that occur in the PBN during taste memory formation. PMID:23063932

Lin, Jian-You; Amodeo, Leslie Renee; Arthurs, Joe; Reilly, Steve

2012-11-01

158

[Tactics of preoperative infusion therapy in obturation jaundice].  

Science.gov (United States)

The influence of the infusion therapy content on a hepatic function of bile outflow (HFBO), a bilirubin content and the enzymes activity in obturation jaundice in 139 patients was studied up. In 54 patients (the first group) a Ringer solution and 10% solution of glucose in 1:1 ratio were applied; in 37 patients (the second group) - a sterofundin-G-5 solution; in 48 patients (the third group) - remaxol in a dose of 800 ml/day. Application of sterofundin-G-5 and remaxol as a component of infusion therapy have promoted a bile outflow intensity enhancement in early postoperative period in comparison with such while Ringer solution and 10% solution of glucose application. Remaxol more effectively have eliminated a hyperbilirubinemia, enzymemia and a HFBO disorder, than sterofundin-G-5. PMID:22295543

Iakovlev, A Iu; Semenov, V B; Emel'ianov, N V; Mokrov, K V; Akulenko, S V; Zarechnova, N V

2011-10-01

159

Analysis of intracranial pressure waveform during infusion test.  

Science.gov (United States)

An analysis of intracranial pressure (ICP), based on an examination of the temporary correlation between the changes in amplitude of the pulse wave and the mean ICP level, is presented. The paper contains a discussion of the preliminary results of the method when applied to the analysis of ICP as monitored during infusion tests in a group of 24 children. Infusion of a certain volume of CSF is a good example of an uncompensated volume process, introduced externally into the intracranial space. Results allow an interpretation of the short term correlation coefficient RAP (correlation coefficient between ICP and variations of the amplitude of fundamental component of the pulse wave AMP), as a steady state index. According to this interpretation, the presented analysis enables the observation of a loss of equilibrium during the test. Other phenomena can also be observed, for instance a recovery to equilibrium after the test, nonlinearities of amplitude-pressure relationship, vasomotor reflexes etc. PMID:3177031

Czosnyka, M; Wollk-Laniewski, P; Batorski, L; Zaworski, W

1988-01-01

160

Is the Tecoma stans infusion an antidiabetic remedy?  

Science.gov (United States)

The intravenous administration of Tecoma stans infusion in normal dogs produces an early hyperglycemic response and arterial hypotension followed by a slow decrease of the glucose blood values with a concomitant hypertriglyceridemia; no important changes in immunoreactive insulin were detected. Heart frequency was gradually increased after the first 60 min of drug administration and persisted for several hours. The effects observed on blood parameters seem to be related to hepatic glycogen metabolism, involving an activation of glycogenolysis. The late hypoglycemic effect of Tecoma stans infusion could be considered secondary to the observed hepatic glucose output. The study represents an attempt to elucidate the popularly attributed antidiabetic properties of this Mexican medicinal plant. PMID:3910963

Lozoya-Meckes, M; Mellado-Campos, V

1985-09-01

 
 
 
 
161

Abnormal thallium 201 scintigraphy during low-dose vasopressin infusions  

International Nuclear Information System (INIS)

Thallium 201 (201Tl) myocardial scans were obtained in 16 patients just prior to the discontinuation of a vasopressin infusion (.1 to .2 units/min) administered for the treatment of upper gastrointestinal bleeding. Repeat scintigraphy was performed two to three hours after the vasopressin was stopped. Eleven of the 16 patients (69 percent) demonstrated areas of decreased myocardial 201Tl uptake that resolved after the infusion was stopped. Heart rate-blood pressure product was significantly lower at the time of the second scan. Autopsies were secured in three of 11 scan-positive patients: one had severe coronary artery obstruction, one nonsignificant disease, and another had normal coronary arteries. Vasopressin, even at low doses, can induce abnormalities in myocardial perfusion that are probably mediated by a direct effect on the coronary circulation. They are usually not detectable by routine monitoring techniques and conceivably form the basis for the cardiovascular morbidity associated with the use of this agent

162

Patterned polymer films via reactive silane infusion-induced wrinkling.  

Science.gov (United States)

A method for simultaneously patterning and functionalizing thin poly(2-hydroxyethyl methacrylate) films through a reactive silane infusion based wrinkling is developed. Wrinkled patterns with tunable wavelengths on submicrometer size are easily produced over large area surfaces and can express a wide variety of chemical functional groups on the surface. The characteristic wavelength of wrinkling scales linearly with initial film thickness, in agreement with a gradationally swollen film model. Results from X-ray photoelectron spectroscopy confirm that the wrinkled film is composed of two layers: a gradient cross-linked top layer and a uniform un-cross-linked bottom layer. The surface chemical properties of wrinkles can be easily tuned by infusion of different functional silanes. Hierarchical wrinkled patterns with micro/nano structure can be achieved by combining wrinkling with other simple lithography methods. Wrinkled nanopatterns can be used as a mold to transfer the topology to a variety of other materials using nanoimprint lithography. PMID:23496840

Li, Yinyong; Peterson, Joseph J; Jhaveri, Sarav B; Carter, Kenneth R

2013-04-01

163

Radionuclide assessment of the hepatic arterial chemotherapy infusion pump  

International Nuclear Information System (INIS)

Since 1982, physicians at the Medical College of Ohio, Toledo, have performed 38 hepatic intraarterial chemotherapy infusion pump implantations for palliative treatment of metastatic liver disease from various primary tumors of the gastrointestinal tract. Radionuclide hepatic arterial pump imaging has proved to be an extremely reliable, cost-effective, and uncomplicated method of evaluating the pump function and liver perfusion. Scanning can be performed both before and during chemotherapy administration. Furthermore, during the course of chemotherapy, CT and intravenous sulfur colloid imaging of the liver can be used to follow the effectiveness of the infusion. The chemotherapeutic program can then be modified accordingly. The exhibit includes an illustration of the technique and analysis of results

164

Studies on the subcommissural organ area in the rat: the effects aldosterone infused into the central nervous system  

International Nuclear Information System (INIS)

D-aldosterone (5 ng/?l/hr) was infused for six days into the area of the subcommissural organ (SCO) of conscious rats to test the hypothesis that the SCO and the adrenal zona glomerulosa are related functionally in a negative feedback manner. Aldosterone increased urinary sodium loss and the sodium/potassium ratio. These effects still occurred when cannulae were displaced caudally up to 1 mm from the targeted SCO area. Aldosterone decreased the cross-sectional area of the adrenal medulla without affecting chromaffin cell density. Adrenal content of corticosterone was increased. These effects were highly dependent upon proper cannula placement and were not observed when the tip of the cannula was not in contact with the cerebrospinal fluid of the pineal recess over the rostral two-thirds of the SCO. Aldosterone infused intracerebroventricularly (ivt) into a lateral ventricle had no effect on sodium excretion, adrenal corticosterone concentration or adrenal morphology. After the infusion of radiolabelled aldosterone into the SCO area, the majority of the radioactivity was restricted to an area about 1-2 mm in diameter from the SCO. Iron-dextran injected intraperiotoneally did not accumulate in the SCO; therefore, the blood-brain barrier is intact. It is concluded that the effects of aldosterone were dependent upon the area of the brain in which it was infused. Aldosterone increased sodium excretion by an action in the SCO and/or adjacent structures. A relationship between mineralocorticoids and the adrenal modulla mediated by the SCO is also postulated. With regard to the blood-brain and brain-CSF barriers, the SCO more closely resembles general brain tissue than other circumventricular organs

165

Continuous infusion of methylene blue for septic shock.  

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Nitric oxide has been determined to be a potential mediator of the haemodynamic changes associated with sepsis. The haemodynamic eects of nitric oxide can be partially antagonised by methylene blue, through inhibition of the enzyme, guanylate cyclase. The case report presented here demonstrates a beneficial haemodynamic eect of continuous infusion of methylene blue during sepsis. These findings could be extrapolated to other patients or prompt additional research.

Brown, G.; Frankl, D.; Phang, T.

1996-01-01

166

Hospital selection of home infusion therapy companies as preferred providers.  

Science.gov (United States)

The process by which a hospital selected home infusion therapy providers is described. Administrators at a 379-bed teaching hospital decided to attempt to reduce the high mean length of stay by expanding the use of home infusion therapy. Direct diversification into this field by the hospital was not feasible, so it was decided to establish contractual agreements with providers. A task force was appointed to evaluate and choose vendors in the area and to increase the number of patient referrals. The task force examined reports on past experience with providers, price lists, the range and level of services offered, and the amount of free care given and visited the companies' facilities. The group designated three providers as preferred and two as unacceptable. The number of patients referred increased from 21 during the 12 months before the task force was convened to 46 in the first 9 months afterward, for a saving of 2198 patients days. After one year the task force met again to consider company requests for evaluation or reevaluation, establish a plan for publicizing the benefits of home infusion therapy, and replace the site visits with a requirement for accreditation by the Joint Commission. After two years, the task force developed provider-evaluation criteria to streamline the process and reflect the experience gained. The responsibility for reviewing providers was transferred to the P&T committee. When a direct venture into home infusion therapy is not fiscally desirable, contracting for services can still offer the advantages of reduced length of stay and decreased drug expenses. PMID:1621728

Rich, D S; Ayers, N

1992-07-01

167

Cardiovascular effects of intravenous ghrelin infusion in healthy young men  

DEFF Research Database (Denmark)

Ghrelin infusion improves cardiac function in patients suffering from cardiac failure, and bolus administration of ghrelin increases cardiac output in healthy subjects. The cardiovascular effects of more continuous intravenous ghrelin exposure remain to be studied. We therefore studied the cardiovascular effects of a constant infusion of human ghrelin at a rate of 5 pmol/kg per minute for 180 min. Fifteen healthy, young (aged 23.2 +/- 0.5 yr), normal-weight (23.0 +/- 0.4 kg/m(2)) men volunteered in a randomized double-blind, placebo-controlled crossover study. With the subjects remaining fasting, peak myocardial systolic velocity S', tissue tracking TT, left ventricular ejection fraction EF, and endothelium-dependent flow-mediated vasodilatation were measured. Ghrelin infusion increased S' 9% (P = 0.002) and TT 10% (P <0.001), whereas EF, resting blood flow velocity, and endothelium-dependent flow-mediated vasodilatation did not change (P = 0.13). This was associated with a peak in serum growth hormone after 60 min of infusion (37.77 +/- 5.27 ng/ml, P <0.001), a doubling of free fatty acid levels (P = 0.001), and a 1.6-fold increase in cortisol levels (P <0.05), whereas glucose and catecholamine levels were constant. In conclusion, supraphysiological levels of ghrelin stimulate left ventricular function in terms of S' and TT in healthy young normal-weight men without changing resting blood flow velocity and endothelium-dependent flow-mediated vasodilatation. The effects did not translate into detectable increments in EF.

Vestergaard, Esben Thyssen; Andersen, Niels Holmark

2007-01-01

168

Saline infusion sonohysterography versus hysteroscopy for uterine cavity evaluation  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Background and Objectives: The most frequent procedures performed on women with abnormal uterine bleeding are 2D and 3D ultrasound. The most common accepted approach for the management of abnormal uterine bleeding is 2D TV scan followed by therapeutic hysteroscopy. The purpose of this prospective study was to assess whether 3D saline infusion sonohysterography (3D SIS) could replace diagnostic hysteroscopy (DH) for the diagnosis of endometrial pathology, in patients with abnormal uteri...

Khan Faryal; Jamaat Sadia; Al-Jaroudi Dania

2011-01-01

169

Rapid infusion with rituximab: short term safety in systemic autoimmune diseases  

DEFF Research Database (Denmark)

To describe the incidence, types and severity of adverse events, related to an accelerated regime of rituximab infusion in patients with various autoimmune diseases. Fifty-four patients with systemic autoimmune disease, to be treated with 1,000 mg of rituximab twice 2 weeks apart, participated. Pre-medication (oral prednisolone, anti-histamine and paracetamol) was administered 1-4 h before infusion start. The first infusion was administered over a period of 195 min. The second infusion over a period of 90 min. Any adverse events were classified using the Clinical Trials Classification of Adverse Events (CTCAE) v. 3.0. Ten patients (18.5%) experienced at least one infusion-related reaction (IRR) ever. The first infusion was associated with reactions in 4 CTCAE categories of which rhinitis were the most frequent. The CTCAE severity grading showed six patients (11.1%) had a grade 1 reaction. One patient (1.8%) had grade 2 events on both infusions and two patients (3.6%) had a grade 3 event on both infusions. RA patients more often had an infusion-related reaction (IRR) (9.2%) than the rest. The types of IRR were mostly of allergic or angio-oedematic nature. In practise, the rapid infusion was an easy to use regime and the second infusion is of time sparing significance to health professionals. No unexpected side effects were observed in relation to the accelerated regime.

Larsen, Janni Lisander; Jacobsen, Soren

2013-01-01

170

Confirmation of uncontrolled flow dynamics in clinical simulated multi-infusion setups using absorption spectral photometry  

Science.gov (United States)

Multi-infusion systems are used frequently at intensive care units to administer several liquid therapeutic agents to patients simultaneously. By passively combining the separate infusion lines in one central line, the number of punctures needed to access the patient's body, is reduced. So far, the mutual influence between the different infusion lines is unknown. Although the flow properties of single infusion systems have been investigated extensively, only a few research groups have investigated the flow properties of multi-infusion systems. We showed in a previous study that applying multi-infusion can lead to fluctuations in syringe pump infusions, resulting in uncontrolled and inaccurate drug administration. This study presents a performance analysis of multi-infusion systems as used in the Neonatology Intensive Care Unit. The dynamics between multiple infusion lines in multi-infusion systems were investigated by simulation experiments of clinical conditions. A newly developed real-time spectral-photometric method was used for the quantitative determination of concentration and outflow volume using a deconvolution method of absorption spectra of mixed fluids. The effects for common clinical interventions were studied in detail. Results showed mutual influence between the different infusion lines following these interventions. This mutual influence led to significant volume fluctuations up to 50%. These deviations could result in clinically dangerous situations. A complete analysis of the multiinfusion system characteristics is recommended in further research to estimate both the presence and severity of potential risks in clinical use.

Timmerman, Anna M.; Riphagen, Brechtje; Klaessens, John H.; Verdaasdonk, Rudolf M.

2010-02-01

171

Metabolic effects of chronic obestatin infusion in rats.  

Science.gov (United States)

Obestatin is purported to be a peptide hormone encoded in preproghrelin. We studied the metabolic effects of continuous infusion of obestatin via subcutaneously implanted osmotic mini-pumps. Administration of up to 500nmol/kg body weight/day obestatin did not change 24h cumulative food intake or body weight in rats. Similarly, no effects were observed when obestatin was infused at 1000nmol/kg body weight/day for seven days. This dose of obestatin infused during a 24h fast did not alter weight loss, suggesting that obestatin has no effect on energy expenditure, and this dose did not alter glucose or insulin responses during an IPGTT. Obestatin was originally proposed to interact with GPR39 and subsequently the receptor for GLP-1. While both receptors are expressed in pancreatic islets, incubation with obestatin did not alter insulin release from islets in vitro. Moreover, obestatin did not bind to INS-1 beta-cells or HEK cells overexpressing GLP-1 receptors or displace GLP-1 binding to these cells. Our findings do not support the concept that obestatin is a hormone with metabolic actions. PMID:18508160

Unniappan, Suraj; Speck, Madeleine; Kieffer, Timothy J

2008-08-01

172

Regional blood flow during continuous low-dose endotoxin infusion  

International Nuclear Information System (INIS)

Escherichia coli endotoxin (ET) was administered to adult rats by continuous IV infusion from a subcutaneously implanted osmotic pump (Alzet). Cardiac output and regional blood flow were determined by the radiolabeled microsphere method after 6 and 30 hr of ET or saline infusion. Cardiac output (CO) of ET rats was not different from time-matched controls, whereas arterial pressure was 13% lower after 30 hr of infusion. After both 6 and 30 hr of ET, pancreatic blood flow and percentage of cardiac output were lower than in controls. Estimated portal venous flow was decreased at each time point, and an increased hepatic arterial flow (significant after 30 hr) resulted in an unchanged total hepatic blood flow. Blood flow to most other tissues, including epididymal fat, muscle, kidneys, adrenals, and gastrointestinal tract, was similar between treatments. Maintenance of blood flow to metabolically important tissues indicates that the previously reported alterations in in vitro cellular metabolism are not due to tissue hypoperfusion. Earlier observations of in vitro myocardial dysfunction, coexistent with the significant impairment in pancreatic flow, raise the possibility that release of a myocardial depressant factor occurs not only in profound shock but also under less severe conditions of sepsis and endotoxemia

173

Potential integration of gas infusion into a fuel cell system  

Energy Technology Data Exchange (ETDEWEB)

'Full text:' An innovative gas infusion polymer electrolyte membrane (PEM) fuel cell prototype has been developed. PEM Fuel cell is operated under pressurized hydrogen gas and super oxygenated water. Gas infusion delivers super oxygenated water to the PEM fuel cell cathode at concentrations between 50 and 200 ppm, which overwhelms the limitation of 7 ppm concentration due to Henry's Law of the water within the cell. With adequate mixing, the water adjacent to the catalyst sites will have a higher concentration of oxygen than would be experienced in a cell running with the conventional method. The membrane is fully hydrated since the stack is constantly being fed with a liquid stream, which is recycled. Thermal management can be easily accomplished by liquid stream feed. The simple design of stack components, i.e. bipolar plate, gas diffusion layer (GDL) is studied. Application of gas infusion concepts in PEM fuel cell may alleviate cathode flooding and membrane dehydration problems in the absence of a humidifier. (author)

Qiu, L.; Fowler, M.W.; Ioannidis, M. [Univ. of Waterloo, Dept., of Chemical Engineering, Waterloo, Ontario (Canada); Archibald, J. [inVentures Technologies Inc., Oakville, Ontario (Canada)

2004-07-01

174

Potential integration of gas infusion into a fuel cell system  

Energy Technology Data Exchange (ETDEWEB)

An innovative gas infusion polymer electrolyte membrane (PEM) fuel cell prototype was presented along with the many factors that influence its performance. The fuel cell operates under pressurized hydrogen gas and super oxygenated water. The study showed that PEM fuel cells can be operated with super-oxygenated water on the cathode and dry hydrogen on the anode. Improved fuel cell performance can be achieved by raising the temperature, the fuel cell and gas infuser pressure, and the flow rate of the super-oxygenated water. The gas infuser provides super-oxygenated water to the cathode and can be integrated into a fuel cell system. A humidification subsystem is not required because hydration of the membrane is readily achieved because the stack is constantly being fed with a liquid stream. It was noted that a liquid cathode feed offers better thermal control adjacent to the membrane. Since no separate cooling system is needed, the design of the fuel cell system can be simpler in terms of stack components, bipolar plates, gas diffusion layer and membrane electrode assembly. The need for a porous structure becomes less critical with this simple design. In the future, solar or wind energy will produce electricity from electrolysers. Then, in a closed loop system, both hydrogen and oxygen can be fed to fuel cells. It was concluded that unique membrane electrode assemblies for liquid flow at the cathode are still in the developmental stage for their potential uses with metal foams. 7 refs., 9 figs.

Qiu, L.; Fowler, M.W.; Ioannidis, M. [Waterloo Univ., ON (Canada). Dept. of Chemical Engineering; Archibald, J.; Glassford, C. [InVentures Technologies Inc., Oakville, ON (Canada)

2005-07-01

175

Review of pharmacokinetic models for target controlled infusions in anesthesia  

Directory of Open Access Journals (Sweden)

Full Text Available Intravenous injection of anesthetic drugs dates back to the 17th Century when opium and chloral hydrate have been injected intravenously. It was not until the 1930s intravenous anesthesia became popular with the invention of barbiturates.Early intravenous anesthetic agents such as barbiturates were ideal for induction of anesthesia, but not suitable for maintenance of anesthesia. Most of these drugs accumulated significantly with increasing durations of infusion and also resulted in cardiorespiratory depression. The invention of propofol and shorter acting opioid analgesics such as remifentanil and alfentanil have revolutionized intravenous anesthesia. The rapid onset and offset of these drugs lends itself to being suitable agents for maintenance of anesthesia over prolonged periods of time. Detailed understanding of the pharmacokinetics of propofol and remifentanil, combined with technological advances in intravenous pumps capable of accurate delivery of drugs have resulted in great development of the field of total intravenous anesthesia and target controlled infusions. I would like to discuss, in this article, the pharmacokinetics and pharmacokinetic models behind these intravenous infusion pumps. [Int J Basic Clin Pharmacol 2014; 3(3.000: 417-423

Subash Kennedy Sivasubramaniam

2014-06-01

176

Attraction of Aedes albopictus adults in sod infusion.  

Science.gov (United States)

Aedes albopictus adults were recovered from sod-baited gravid traps at 7 sites in 5 counties of southern and southwestern Illinois in areas ranging from suburban to rural. The attraction of this species to a lure usually associated with members of the Culex pipiens complex was investigated under laboratory and field conditions. Olfactometer and oviposition preference tests in the laboratory showed that Ae. albopictus is attracted to sod infusion and females readily oviposit on substrates in contact with the infusion. Both males and females responded to the sod infusion in the olfactometer. The attraction of multiple mosquito species to sod-baited gravid traps was demonstrated at a waste tire site in Jasper County, Illinois. Females of Ae. albopictus, Aedes triseriatus, and Culex species were collected from gravid traps placed along the edge of woods at distances ranging from 100 to 200 m from the tire site. Only a small percentage of the Ae. albopictus females appeared to be gravid (less than 5%), unlike the majority of Culex and Ae. tristeriatus females. PMID:8723268

Lampman, R L; Novak, R J

1996-03-01

177

The effect of chronic subarachnoid bupivacaine infusion in dogs.  

Science.gov (United States)

A functional and histologic examination of the effect of the continuous intrathecal administration of bupivacaine was made in five dogs. After a partial laminectomy at L5, a silicone rubber catheter was inserted into the subarachnoid space and advanced 10 cm cranially. A model 400 Infusaid pump, used for drug delivery, was placed in a subcutaneous pocket between the 13th rib and iliac crest. Drug infusions were individually adjusted and maintained at a concentration such that the animal just exhibited slight gait impairment. Daily bupivacaine doses ranged from 5.7-11.1 mg. Infusions were maintained for a period of 3-16 weeks. Light microscopic examination of spinal cord and roots revealed no abnormalities. A focal mononuclear cell infiltration of the leptomeninges was seen in two drug animals, as well as one catheter control animal. One of the 16-week animals had a residual limp upon drug removal. While we were not able to quantitatively assess the degree of sensory motor dissociation, the results of this study suggest that chronic intrathecal bupivacaine infusion through an implantable pump system may be a short-term alternative to intrathecal morphine in the control of cancer pain. PMID:3592272

Kroin, J S; McCarthy, R J; Penn, R D; Kerns, J M; Ivankovich, A D

1987-06-01

178

Octreotide infusion or emergency sclerotherapy for variceal haemorrhage.  

Science.gov (United States)

To compare octreotide with injection sclerotherapy in the treatment of acute variceal haemorrhage, patients admitted with gastrointestinal bleeding and oesophageal varices confirmed by endoscopy were randomised to receive either emergency sclerotherapy with 3% sodium tetradecyl sulphate or octreotide (50 micrograms intravenous bolus plus 50 micrograms per h intravenous infusion for 48 h). At the end of the study period (48 h), the octreotide group also had sclerotherapy to obliterate the varices. 100 patients were recruited. Demographic features including the aetiology of portal hypertension and the Child-Pugh's grading of the two groups were similar. Bleeding was initially controlled in 90% of patients by emergency sclerotherapy and in 84% by octreotide infusion (95% confidence interval 0-19.5, p = 0.55). There were no significant differences between the two groups in early (within 48 h of randomisation) rebleeding (16% vs 14%), blood transfusion (3 units vs 3.5), hospital stay (5 days vs 6 days), or hospital mortality (27% vs 20%). No notable side-effects were associated with octreotide. We conclude that octreotide infusion and emergency sclerotherapy are equally effective in controlling variceal haemorrhage. PMID:8103145

Sung, J J; Chung, S C; Lai, C W; Chan, F K; Leung, J W; Yung, M Y; Kassianides, C; Li, A K

1993-09-11

179

Preliminary results of a randomized study of intrahepatic infusion versus systemic infusion of FUDR for metastatic colorectal carcinoma  

International Nuclear Information System (INIS)

This paper presents a randomized study that compares intrahepatic infusion to systemic infusion applying the same chemotherapeutic agent (FUDR), schedule, and method of administration. Radiation therapy patients with measurable metastatic colorectal carcinoma to the liver, without extrahepatic disease, are eligible. Patients with a Karnofsky Performance Status less than 60% and a serum bilirubin greater than 4.0 mg/d1 are excluded. To date, 11 partial responses (PR's) in 26 evaluable patients were seen in the intrahepatic group and 8 PR's in 24 evaluable patients in the systemic group. The median duration of response is 7 months for both groups. There were two minor responses in each group. In the systemic group, 3 patients have stable disease for 4-13+ months. Fifteen patients in the intrahepatic group and 10 patients in the systemic group have had more than 50% reduction in carcinoembryonic antigen level

180

Changes in basal insulin infusion rates with subcutaneous insulin infusion: time until a change in metabolic effect is induced in patients with type 1 diabetes.  

Science.gov (United States)

OBJECTIVE Evaluation of the time required until a change in the basal insulin infusion rate with an insulin pump induces subsequent changes in the metabolic effect. RESEARCH DESIGN AND METHODS In this euglycemic glucose clamp study, 10 male subjects with type 1 diabetes received three different subcutaneous insulin infusion rates (0.5, 1.0, and 2.0 units/h; for 4 h each) of insulin lispro (IL) with insulin pumps. RESULTS An increase in insulinemia occurred within 15-30 min after changing the infusion rate. While the serum IL levels reached a steady state at the end of the infusion period, the glucose infusion rates did not always reach steady-state levels with the higher infusion rates. However, an increase in the glucose consumption occurred within 30-60 min after switching the infusion rate. CONCLUSIONS Several hours are required until a new steady state in the metabolic effect is achieved after a significant change in basal insulin infusion. PMID:19487635

Heinemann, Lutz; Nosek, Leszek; Kapitza, Christoph; Schweitzer, Matthias-Axel; Krinelke, Lars

2009-08-01

 
 
 
 
181

Clinical assessment of first pass radionuclide ventriculography after dipyridamole infusion in patients with coronary artery disease  

International Nuclear Information System (INIS)

First pass radionuclide ventriculography (RNV) was performed after dipyridamole (D) infusion in 33 patients with coronary artery disease (CAD) and 15 normal volunteers. RNV findings after D infusion were compared with those of conventional exercise RNV and body surface ECG mapping (MAP). For patients with multiple vessel disease, left ventricular ejection fraction (LVEF) was significantly lower after D infusion than at rest. Wall motion abnormality (WMA) sites induced by D infusion were well coincident with those induced by exercise. Pressure rate product at exercise was significantly higher than that after D infusion, suggesting the different mechanism of the occurrence of WMA after D infusion and at exercise. The incidence of ischemic reaction tended to be higher after D infusion than at exercise in 25 patients with CAD. There was negative correlation between ST depression on MAP after D infusion and LVEF on RNV after D infusion. This RNV after D infusion can be used as a supplement tool to conventional exercise RNV in the evaluation of the degree of coronary artery lesions and preserved left ventricular function. (Namekawa, K.)

182

Safe and tolerable one-hour pamidronate infusion for multiple myeloma patients  

Directory of Open Access Journals (Sweden)

Full Text Available Dimitrios Chantzichristos, Andréasson Björn, Johansson PeterDepartment of Internal Medicine, Uddevalla Hospital, Uddevalla, SwedenBackground: Once a month, patients with multiple myeloma received an infusion of bisphosphonates, principally to reduce osteoclastic bone resorption. Recommended infusion time for pamidronate is 2 hours in the US and 4 hours in Europe because of its potential nephrotoxicity. From 2003, a 90 mg infusion of pamidronate was provided over 1 hour to patients with no pre-existing renal impairment, in the Daily Care Unit at Uddevalla Hospital.Method: Retrospective analysis of the renal deterioration, serum calcium, and adverse effects in patients with multiple myeloma treated with 1-hour pamidronate 90 mg infusion from January 2003 to April 2007.Results: Seventy-nine patients provided valuable data. A total number of 846 infusions were given and the median number of infusion to each patient was 11. Significant creatinine elevation was seen in 7 patients (8.9%, after 19 infusions (2.2%. Renal deterioration occurred in 5 of these 7 patients, which was related to progress of the myeloma or opportunistic infections. Prevalence of infusion-related events was 0.8% and the mean total S-Ca was 0.05 mmol/L lower than the baseline.Conclusion: Few events of renal deterioration, hypocalcemia, or other adverse effects resulted from a 1-hour pamidronate 90 mg infusion for multiple myeloma patients with no pre-existing renal impairment.Keywords: bisphosphonates, pamidronate, multiple myeloma, infusion time

Dimitrios Chantzichristos

2008-09-01

183

Golden Sections  

Science.gov (United States)

In this article, the author states that architects, musicians and other thoughtful people have, since the time of Pythagoras, been fascinated by various harmonious proportions. One, is the visual harmony attributed to Euclid, called "the golden section". He explores this concept in geometries of one, two and three dimensions. He added, that in…

Stuart, Stephen N.

2006-01-01

184

Pantoprazole before Endoscopy in Patients with Gastroduodenal Ulcer Bleeding: Does the duration of Infusion and Ulcer Location Influence the Effects?  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The aim of this study was to investigate the effect of preemptive pantoprazole infusion on early endoscopic findings in patients with acute ulcer bleeding. Records of 333 patients admitted with acute ulcer bleeding were analyzed. Ulcer bleeders were given either 80?mg bolus of pantoprazole followed by continuous infusion of 8?mg per hour or saline infusion until endoscopy. In 93 patients saline infusion whereas in 240 patients bolus plus infusion of pantoprazole was administrated with mea...

Ra?cz, Istvan; Szalai, Milan; Dancs, Nora; Ka?ra?sz, Tibor; Szabo?, Andrea; Cso?ndes, Mihaly; Horva?th, Zoltan

2012-01-01

185

Behavioral differences in a rotenone-induced hemiparkinsonian rat model developed following intranigral or median forebrain bundle infusion.  

Science.gov (United States)

A mitochondrial complex-I inhibitor, rotenone was unilaterally infused into the substantia nigra pars compacta (SNpc) or median forebrain bundle (MFB) to create hemiparkinsonian animal models and investigated spontaneous and drug-induced stereotypic rotations, as well as certain postural behaviors in Sprague-Dawley rats. Animals infused intranigrally, but not intra-MFB, with rotenone exhibited spontaneous contralateral rotations immediately after recovery from anesthesia. Head position bias and elevated body swing test showed insignificant contralateral bias in animals with nigral damage but a significant ipsilateral bias in MFB-lesioned rats. General motor activity of the animals was reduced in both the groups as indicated by reduced performance on a Plus-Maze. Intranigrally, rotenone-infused animals exhibited progressive ipsilateral rotations when challenged with d-amphetamine on the 7th, 14th, 21st, and 28th days or with apomorphine on 9th, 16th, 23rd, and 30th days. However, animals that received rotenone in MFB exhibited ipsilateral or contralateral rotations when challenged respectively with d-amphetamine or apomorphine only in the 5th week (28th and 30th days). Stereotaxic administration of rotenone into SNpc or MFB caused a significant loss of dopamine in the ipsilateral striatum (>80% in SNpc; >95% in MFB), when assayed employing an HPLC equipped with electrochemical detector on the 32nd day. Neuronal loss in SNpc was confirmed in coronal sections stained with cresyl violet and revealed extension of lesion towards SN pars reticulata, in SNpc-infused animals. Our results demonstrate that rotenone-induced neurodegeneration is a slow, yet progressive process similar to that in idiopathic Parkinson's disease and unlike that observed in other classical neurotoxin-mediated lesions which are abrupt and developed in few hours to days. Thus, intranigral or intra-MFB infusion of rotenone could be used for producing hemiparkinsonian animal models in rats. These findings further suggest that, while both d-amphetamine and apomorphine-induced stereotypic rotations could be used as a valuable behavioral assay procedure to test novel drugs against Parkinson's disease, yet apomorpine-induced contralateral bias in turning is a reliable indicator of specific destruction in nigrostriatal pathway and development of postsynaptic dopamine receptor supersensitivity. PMID:15992782

Sindhu, Kizhakke M; Saravanan, Karuppagounder S; Mohanakumar, Kochupurackal P

2005-07-27

186

Effect of magnesium infusion on thoracic epidural analgesia  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction: Patients of lung volume reduction surgery (LVRS having an ASA status III or more are likely to be further downgraded by surgery to critical levels of pulmonary function. Aim: To compare the efficacy of thoracic epidural block with (0.125% bupivacaine, fentanyl combination and (0.125% bupivacaine, fentanyl combination with adjunctive intravenous magnesium infusion for the relief of postoperative pain in patients undergoing LVRS. Methods: Patients were operated under general anesthesia. Thirty minutes before the anticipated completion of skin closure in both groups, (Group A and Group B 7 ml of (0.125% bupivacaine calculated as 1.5 ml/thoracic segment space for achieving analgesia in dermatomes of T4, T5, T6, T7, and T8 segments, along with fentanyl 50 ?g (0.5 ml, was administered through the catheter, activating the epidural block, and the time was noted. Thereafter, in patients of Group A, magnesium sulfate injection 30 mg/kg i.v. bolus was followed by infusion of magnesium sulfate at 10 mg/kg/hr and continued up to 24 hours. Group B was treated as control. Results and Analysis: A significant increase in the mean and maximum duration of analgesia in Group A in comparison with Group B (P<0.05 was observed. Total epidural dose of fentanyl and bupivacaine required in Group A was significantly lower in comparison with Group B in 24 hours. Discussion: Requirement of total doses of local anesthetics along with opioids could be minimized by magnesium infusion; therefore, the further downgradation of patients of LVRS may be prevented. Conclusion: Intravenous magnesium can prolong opioid-induced analgesia while minimizing nausea, pruritus, and somnolence.

Gupta Sampa

2011-01-01

187

Wave motions in unbounded poroelastic solids infused with compressible fluids  

CERN Document Server

Looking at rational solid-fluid mixture theories in the context of their biomechanical perspectives, this work aims at proposing a two-scale constitutive theory of a poroelastic solid infused with an inviscid compressible fluid. The propagation of steady-state harmonic plane waves in unbounded media is investigated in both cases of unconstrained solid-fluid mixtures and fluid-saturated poroelastic solids. Relevant effects on the resulting characteristic speed of longitudinal and transverse elastic waves, due to the constitutive parameters introduced, are finally highlighted and discussed.

Quiligotti, S; dell'Isola, F

2010-01-01

188

Biological systems drug infusion controller using FREN with sliding bounds.  

Science.gov (United States)

In this paper, a direct adaptive control for drug infusion of biological systems is presented. The proposed controller is accomplished using our adaptive network called Fuzzy Rules Emulated Network (FREN). The structure of FREN resembles the human knowledge in the form of fuzzy IF-THEN rules. After selecting the initial value of network's parameters, an on-line adaptive process based on Lyapunov's criteria is performed to improve the controller performance. The control signal from FREN is designed to keep in the region which is calculated by the modified Sliding Mode Control (SMC). The simulation results indicate that the proposed algorithm can satisfy the setting point and the robust performance. PMID:17073348

Chidentree, Treesatayapun; Sermsak, Uatrongjit

2006-11-01

189

Creating an IPE infusion plan: from foundation to implementation.  

Science.gov (United States)

Today's health care system has embraced the model of collaborative interprofessional efforts among health care professionals to achieve desired patient health outcomes. The Academy can offer the foundational experiences needed to support and develop interprofessional patient-centered plans of care for health professional students. This paper explores one institution's approach to the creation of an infusion plan which the authors have termed a "structured immersion approach" (SIA) to interprofessional education (IPE). The SIA supports "Core Signature IPE" experiences within existing silo-based curriculums that allow for interprofessional education experiences and the appreciation of the importance of interprofessional practice in today's health care. PMID:24925042

Pinto Zipp, Genevieve; Maher, Catherine; LaFountaine, Michael; Rizzolo, Denise; Dayalu, Vikram; Goeckel, Carolyn; Torcivia, Elizabeth; Phillips, H James

2014-01-01

190

Crystallogenic Properties of a Biological Fluid in Chemical Agent Infusion  

Directory of Open Access Journals (Sweden)

Full Text Available There have been studied cocrystallization peculiarities of blood serum with urea water solutions of different concentration (30; 15; 7.5; 3.75 and 1.725% in the ratio 1:1 compared to a proper structure-forming biosubstrate considering the uremia initial level. The urea dose-dependent infusion has been stated to alter the crystallogenic properties of biological fluid up to a full suppression of its proper crystallization in high concentrations of the compound (15 and 30% solutions, however, the shift expression is determined by initial endogenous urea content in blood.

A.K. Martusevich

2011-03-01

191

A naturalistic glyceryl trinitrate infusion migraine model in the rat  

DEFF Research Database (Denmark)

Glyceryl trinitrate (GTN) infusion is a reliable method to provoke migraine-like headaches in humans. Previous studies have simulated this human model in anaesthetized or in awake rodents using GTN doses 10,000 times higher than used in humans. The relevance of such toxicological doses to migraine is not certain. Anaesthesia and low blood pressure caused by high GTN doses both can affect the expression of nociceptive marker c-fos. Therefore, our aim was to simulate the human GTN migraine model in awake rats using a clinically relevant dose.

Ramachandran, Roshni; Bhatt, Deepak Kumar

2012-01-01

192

Section 2  

...Ch 9: Accelerating the Sustainability Revolution Ch 10: Operationalizing Natural Advantage through the Sustainability Helix 3. Economics & Governance Section 3: Natural Advantage ...voluntary environmental initiatives (Bruce Paton) Chapter 10: Operationalizing Natural Advantage through the Sustainability Helix 1 The business case for sustainability 1.1 The management helix ...for the sustainable organization (Sustainability Helix) Sustainable Business Practice Charlie and Cheryl with Rob Coombs, CEO of Interface Australasia, at the ...

193

Corneal Endothelial Cell Density and Morphology Following Bolus versus Infusion Intracameral Adrenaline during Phacoemulsification  

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Full Text Available

PURPOSE: To compare early postoperative corneal endothelial cell density and morphology after phacoemulsification using bolus versus infusion intracameral adrenaline. METHODS: In this randomized clinical trial, 71 eyes of 71 patients scheduled for phaco-emulsification were randomly assigned to two groups: one group (31 eyes received bolus intracameral adrenaline (1:10,000 and the other group (30 eyes received adrenaline infusion (1:1,000,000. Pre- and one month postoperatively, a complete ophthalmologic examination as well as endothelial evaluation using ConfoScan III was performed; effective phaco time (EPT and mydriasis during surgery were also compared between the study groups. RESULTS: The two study groups were not significantly different in terms of demographic characteristics, lens opacity and EPT. Endothelial cell density was 2737±321 cell/mm2 in the bolus group vs 2742±426 cell/mm2 in the infusion group preoperatively (P=0.1. One month postoperatively, the rate of cell loss was 7.21% in the infusion group versus 8.87% in the bolus group (P= 0.13. Pupil diameter was > 6 mm in 48% of eyes in the infusion group vs 33% of eyes in the bolus group (P=0.5. CONCLUSION: Adrenaline was safe at the studied concentrations and there was no significant difference between bolus and infusion routes of administration in terms of pupil dilation and endothelial cell loss.

 
 
201

Motor Stepper Berbasis Mikrokontroller ATMega 8535 Pada Perancangan Sistem Kendali Otomatis Tetesan Cairan Infus Pada Pasien.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The function infuse which is to give intravenous fluids to patients on a regular basis Mistakes in giving intra venous fluids may be detrimental to the patient, also if there are problems with blockage or running out of liquids if not immediately addressed would be dangerous for patients. Infuse the current user is still manually where mistakes – mistakes such as these are still common, there fore we make an infusion control device design that can work automatically and digit...

Nugraha, Arie Yudha

2011-01-01

202

A Generic User Interface Architecture for Analyzing Use Hazards in Infusion Pump Software  

Digital Repository Infrastructure Vision for European Research (DRIVER)

This paper presents a generic infusion pump user interface (GIP-UI) architecture that intends to capture the common characteristics and functionalities of interactive software incorporated in broad classes of infusion pumps. It is designed to facilitate the identification of use hazards and their causes in infusion pump designs. This architecture constitutes our first effort at establishing a model-based risk analysis methodology that helps manufacturers identify and mitigate use hazards in t...

Masci, Paolo; Zhang, Yi; Jones, Paul; Thimbleby, Harold; Curzon, Paul

2014-01-01

203

Analysis of the Environmental Impact of Insulin Infusion Sets Based on Loss of Resources with Waste  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Insulin pump therapy [continuous subcutaneous insulin infusion (CSII)] requires regular change of infusion sets every 2-3 days in order to minimize the risk of skin irritations or other adverse events. This has been discussed to be a potential burden to the environment. The purpose of this analysis was to perform an environmental assessment of insulin pump infusion sets based on loss of resources occurring during incineration of the discarded products and by means of a lifecycle concept used ...

Pfu?tzner, Andreas; Musholt, Petra B.; Malmgren-hansen, Bjoern; Nilsson, Nils H.; Forst, Thomas

2011-01-01

204

Aluminum Contents in Dry Leaves and Infusions of Commercial Black and Green Tea Leaves: Effects of Sucrose and Ascorbic Acid Added to Infusions  

Directory of Open Access Journals (Sweden)

Full Text Available Tea consumption has increased due to its beneficial effects. Results from a lab study on the effect of sucrose (5 g per cup, 150 mL and/or ascorbic acid (2 mL per cup, 150 mL on dissolved aluminum compounds during the infusion of two commercial types of dry tea leaves (black, green with boiling water (5, 15 min infusion time are presented. Factors influencing the presence of dissolved aluminum in the infusions of both tea leaves were infusion time and sugar contents, as well as the interaction between ascorbic acid and sucrose (p < 0.05. Aluminum contents found after 15 min of infusion were 0.7 mg L–1 for black tea infusions added with sugar, and 0.69 mg L–1 for green tea added with both sugar and ascorbic acid. Both concentrations are higher than the level accepted in Mexico for drinking water (there is no act concerning tea infusions, that is 0.2 mg L–1.

Diego Armando Bárcena-Padilla

2011-09-01

205

[Successful treatment of chronic disseminated intravascular coagulation syndrome with continuous subcutaneous infusion of heparin using a mobile infusion pump: report of 2 cases].  

Science.gov (United States)

We report here two patients with chronic disseminated intravascular coagulation (chronic DIC) secondary to aortic aneurysm, who were successfully treated with continuous subcutaneous infusion of heparin. The patients were 69- and 89-year-old males, who were admitted to our hospital because of thrombocytopenia and marked bleeding tendency. The underlying conditions were aortic dissection and aortic aneurysm, respectively. Coagulation test demonstrated that these patients had DIC, and a diagnosis of chronic DIC secondary to aortic aneurysm was made. Anti-coagulation treatment with oral camostat mesylate and daily subcutaneous infusion of heparin calcium was started. However, the treatment was insufficient to control chronic DIC, and these patients developed recurrent severe subcutaneous hemorrhages. Therefore, we attempted continuous subcutaneous infusion of heparin using a mobile infusion pump. This delivery of heparin markedly improved the coagulopathy, and the hemorrhagic episode disappeared with good compliance in the use of infusion equipment in these patients. Continuous subcutaneous infusion of heparin using a mobile infusion pump is effective and useful for long term treatment of chronic DIC by the outpatient department. PMID:20068277

Togami, Katsuhiro; Nagai, Yuya; Arima, Hiroshi; Shimoji, Sonoko; Kimura, Takahiro; Inoue, Daichi; Mori, Minako; Fujita, Haruyuki; Tabata, Sumie; Kurata, Masayuki; Yanagida, Soshi; Matsushita, Akiko; Nagai, Kenichi; Kaji, Shuichiroh; Takahashi, Takayuki

2009-12-01

206

Radiographic and Histologic Study After Infusion of Contrast Media into Rabbit Submandibular Gland  

International Nuclear Information System (INIS)

50 submandibular glands of rabbits were examined historadiologically after infusion with normal and over volumes of physiologic saline and 5 radiographic contrast media. The results were as follows: 1. All water soluble contrast media showed similar radiographic contrasts and absorbed about 5 minutes after infusion except Telebrix 30 which took 30 minutes in both normal and overfilled glands. 2. Lipid soluble medium, Lipiodol UF had excellent radiographic contrast and could be seen on the radiograms even after 24 hours after infusion. 3. Salivary glands infused with physiologic saline didn't show any histologic changes except slight duct dilation right after infusion. 4. Telebrix 30 caused mild to moderate duct dilation and inflammation at immediate and 24 hours after infusion which was more severe in overfilled glands. At 7 days after infusion, there were mild to moderate fibrosis of the gland and areas of necrosis was seen in overfilled glands. 5. Hypaque 60% showed similar histologic reactions to Telebrix 30 except more severe tissue destruction at 7 days after infusion. 6. Urografin 60% showed mildest histologic changes among the media used in the study. 7. Biliscopin had mild duct dilation which returned to normal after 7 days but there were moderate inflammation and tissue necrosis at that time. 8. Lipiodol UF showed severe duct dilation with numerous vacuoles and there were tissue fibrosis at 7 days after infusion but no tissue necrosis was seen.o tissue necrosis was seen.

207

A comparison of continuous infusion of vecuronium and atracurium in midline and paramedian laparotomies.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

This was a study to compare continuous intravenous infusion of atracurium with continuous intravenous infusion of vecuronium for intraoperative muscle relaxation in 62 ASA I / II patients. Scheduled for laparotomies and pelvic surgeries under general anaesthesia. They were randomly allocated in two groups to receive either vecuronium infusion of 50 microg/kg/hour following a bolus dose of 0.1 microg/kg, or atracurium infusion of 400 microg/kg/hour following a bolus dose of 0.5 microg/kg. The ...

Chaudhari L; Shetty A; Buddhi M; Krishnan G

1999-01-01

208

Inhibitory effect of intravenous lysine infusion on urea cycle metabolism.  

Science.gov (United States)

Intravenous infusion of 0.5 mmol/kg L-lysine monohydrochloride was performed in six normal volunteer subjects aged 10-14 years to study the inhibitory effect of lysine on urea cycle metabolism. The lysine infusion resulted in a significant increase in plasma levels of arginine and ornithine, and in urinary homocitrulline, putrescine, and orotic acid, accompanied by a significant increase in blood ammonia. There was little change in plasma urea and citrulline. The increase in plasma arginine appears to reflect an inhibited arginase activity although the plasma urea level did not change. The increased homocitrulline excretion suggests that ornithine conversion to citrulline via ornithine transcarbamylase (OTC) was inhibited. The simultaneous increase in plasma ornithine and urinary putrescine may reflect an inhibition of mitochondrial ornithine transport. In addition to the direct ammoniagenic property of lysine, impaired ornithine conversion to citrulline resulting from the inhibition of both OTC activity and mitochondrial ornithine uptake by lysine may be responsible for the increase in blood ammonia and urinary orotic acid. Despite the retarded citrulline formation, a promoted efflux of citrulline from mitochondria may have kept the plasma citrulline level unchanged. PMID:3107993

Kato, T; Sano, M; Mizutani, N

1987-01-01

209

L-ornithine-L-aspartate infusion efficacy in hepatic encephalopathy  

International Nuclear Information System (INIS)

To determine the efficacy of L-ornithine-L-aspartate in treatment of hepatic encephalopathy. Cirrhotic patients with hyperammonemia and overt hepatic encephalopathy were enrolled. Eighty patients were randomized to two treatment groups, L-ornithine-L-aspartate (20g/d) or placebo, both dissolved in 250mL of 5% dextrose water and infused intravenously for four hours a day for five consecutive days with 0.5 g/kg dietary protein intake at the end of daily treatment period. Outcome variables were postprandial blood ammonia and mental state grade. Adverse reactions and mortality were also determined. Both treatment groups were comparable regarding age, gender, etiology of cirrhosis, Child-Pugh class, mental state grade and blood ammonia at baseline. Although, improvement occurred in both groups, there was a greater improvement in L-ornithine-L-aspartate group with regard to both variables. Four patients in the placebo group and 2 in L-ornithine-L-aspartate group died. L-ornithine-L-aspartate infusions were found to be effective in cirrhotic patients with hepatic encephalopathy. (author)

210

Antioxidant capacity of teas and herbal infusions: polarographic assessment.  

Science.gov (United States)

Hydrogen peroxide scavenging (HPS) activity of unfermented (green, yellow, and white), partially fermented (oolong), and completely fermented (black) tea ( Camellia sinensis ), maté ( Ilex paraguariensis ), and various herbal infusions, as well as individual compounds (flavan-3-ols, flavonols, cinnamic and benzoic acids, and methylxanthines), was assessed by recently developed direct current (DC) polarographic assay. Correlations of tea and herbal infusion HPS activity with total phenolic content determined using the Folin-Ciocalteu assay (FC-GAE) (0.81 and 0.93), ferric reducing/antioxidant power (FRAP) (0.97 and 0.92), 1,1-diphenyl-2-picrylhydrazyl (DPPH) (0.77 and 0.80), and 2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) scavenging (0.86 and 0.86) were statistically significant. Correlations between relative antioxidant capacity index (RACI), calculated by assigning all applied assays equal weight, and HPS (0.98), FRAP (0.97), ABTS (0.89), and DPPH (0.89) confirmed DC polarographic assay reliability when applied individually. Correlation analysis, ANOVA, and Levene and Tukey's HSD tests unequivocally confirmed this reliable, rapid, and low-cost assay validity, clearly demonstrating its advantages over spectrophotometric assays applied. PMID:22950743

Gorjanovi?, Stanislava; Komes, Draženka; Pastor, Ferenc T; Belš?ak-Cvitanovi?, Ana; Pezo, Lato; He?imovi?, Ivana; Sužnjevi?, Desanka

2012-09-26

211

Boron biodistribution after boronophenylalanine-fructose (BPA-F) infusion  

International Nuclear Information System (INIS)

In vivo dynamic tissue boron concentration measurements are not available for BNCT in clinical settings. Whole blood boron concentrations and converting factors are currently used in stead to estimate the boron concentrations in the target tissues and the ensuing radiation doses. We studied with ICP-AES the boron concentrations in blood after 2 hour intravenous infusions of BPA-F in 8 patients (290 mg/kg). As BPA-F is water soluble we calculated respective doses per lean body weight (LBW (360 - 471 mg/kg) - the peak plasma concentrations and area under plasma boron concentration time curve correlated with the mg/LBW dose, but not with dose per skin surface area (mg/m2). The mean boron concentrations in plasma, whole blood and red cells at the infusion were 32.1 ± 3.3, 23.3 ± 2.4 and 9.5 ± 2.8, respectively. LBW doses should be considered to ensure more homogenous dosing and BNCT irradiation. (author)

212

1, 2, 3, 4: infusing quantitative literacy into introductory biology.  

Science.gov (United States)

Biology of the twenty-first century is an increasingly quantitative science. Undergraduate biology education therefore needs to provide opportunities for students to develop fluency in the tools and language of quantitative disciplines. Quantitative literacy (QL) is important for future scientists as well as for citizens, who need to interpret numeric information and data-based claims regarding nearly every aspect of daily life. To address the need for QL in biology education, we incorporated quantitative concepts throughout a semester-long introductory biology course at a large research university. Early in the course, we assessed the quantitative skills that students bring to the introductory biology classroom and found that students had difficulties in performing simple calculations, representing data graphically, and articulating data-driven arguments. In response to students' learning needs, we infused the course with quantitative concepts aligned with the existing course content and learning objectives. The effectiveness of this approach is demonstrated by significant improvement in the quality of students' graphical representations of biological data. Infusing QL in introductory biology presents challenges. Our study, however, supports the conclusion that it is feasible in the context of an existing course, consistent with the goals of college biology education, and promotes students' development of important quantitative skills. PMID:20810965

Speth, Elena Bray; Momsen, Jennifer L; Moyerbrailean, Gregory A; Ebert-May, Diane; Long, Tammy M; Wyse, Sara; Linton, Debra

2010-01-01

213

Solvent infusion processing of all-cellulose composite materials.  

Science.gov (United States)

Continuous fibre-reinforced all-cellulose composite (ACC) laminates were produced in the form of a dimensionally thick (>1 mm) laminate using an easy-to-use processing pathway termed solvent infusion processing (SIP) from a rayon (Cordenka™) textile using the ionic liquid 1-butyl-3-methylimidazolium acetate. SIP facilitates the infusion of a solvent through a dry cellulose fibre preform with the aim of partially dissolving the outer surface of the cellulose fibres. The dissolved cellulose is then regenerated by solvent exchange to form a matrix phase in situ that acts to bond together the undissolved portion of the fibres. SIP is capable of producing thick, dimensionally stable ACC laminates with high volume fractions of continuous fibres (>70 vol.%) due to the combination of two factors: (i) homogeneous and controlled partial dissolution of the fibres and (ii) the application of pressure during regeneration and drying that provides a high level of fibre compaction, thereby overcoming void formation associated with material shrinkage. The effect of inlet and outlet positioning, and applied pressure on the macro- and microstructure of all-cellulose composites is examined. Finally, SIP expands the applications for ACCs by enabling the production of thick ACC laminates to overcome the limitations of conventional thin-film ACCs. PMID:24751100

Huber, Tim; Bickerton, Simon; Müssig, Jörg; Pang, Shusheng; Staiger, Mark P

2012-09-01

214

An overview of infusing service-learning in medical education  

Science.gov (United States)

Objectives To identify and review existing empirical research about service-learning and medical education and then to develop a framework for infusing service-learning in Doctor of Medicine or Doctor of Osteopathic Medicine curricula. Methods We selected literature on service-learning and medical education. Articles were screened with a protocol for inclusion or exclusion at two separate stages. At stage one, articles were screened according to their titles, abstracts, and keywords. The second stage involved a full-text review. Finally, a thematic analysis using focused and selective coding was conducted. Results Eighteen studies were analyzed spanning the years 1998 to 2012. The results from our analysis informed the development of a four-stage service-learning framework: 1) planning and preparation, 2) action, 3) reflection and demonstration, and 4) assessment and celebration. Conclusions The presented service-learning framework can be used to develop curricula for the infusion of service-learning in medical school. Service-learning curricula in medical education have the potential to provide myriad benefits to faculty, students, community members, and university-community partnerships. PMID:25341224

Wubbena, Zane

2014-01-01

215

X-ray Fluorescence in Member States: Philippines. Secrets of Scalar Energy Infused Products as Revealed by XRF Spectrometry  

International Nuclear Information System (INIS)

The Nuclear Analytical Techniques Applications (NATA) Section (formerly the Analytical Measurements Research Section), as part of its function continues to provide analytical services. It has been offering qualitative or semi-quantitative analysis of solid samples using the autoquantify method in the Panalytical Epsilon 5 EDXRF spectrometer. A recent health fad introduced in the market so called scalar energy infused products. Among these are 'Quantum' pendants and so-called energy bracelet/ballers. Claims of their ability to enhance energy levels and balance, detoxify, and prevent cancer have been made. In a demonstration class on the application of nuclear analytical techniques, particularly on the facility of XRF for rapid, nondestructive testing, one participant volunteered to have her 'Quantum' pendant tested. The results of the analysis made her decide to part with her pendant. What did XRF reveal that prompted her to that decision? Analysis of some samples of similar pendants by XRF revealed the secrets of

216

Augmentation of Chemotherapeutic Infusion Effect by TSU-68, an Oral Targeted Antiangiogenic Agent, in a Rabbit VX2 Liver Tumor Model  

International Nuclear Information System (INIS)

Purpose: This study was designed to investigate the in vivo effects of combination therapy with TSU-68 and chemotherapeutic infusion in a rabbit VX2 liver tumor model. Methods: This study was approved by the animal care committee at our institute. Three weeks before chemotherapeutic infusion, VX2 carcinoma was implanted into the livers of 32 rabbits. One week after chemotherapeutic infusion, vehicle was administered orally for 3 weeks in the control group (n = 16), and TSU-68 was administered orally at a daily dose of 200 mg/kg for 3 weeks in the treated group (n = 16). Computed tomography (CT) was performed before and 1, 2, 3, and 4 weeks after chemotherapeutic infusion. Tumor response was assessed according to the Response Evaluation Criteria in Solid Tumors (RECIST) on CT scan. The maximum thickness of viable tumor was measured on microscopic sections. Results: According to the RECIST, stable disease was observed in 9 (56%) rabbits and progressive disease in 7 (44%) in the control group, whereas partial response was observed in 1 (6%) rabbit and stable disease in 15 (94%) in the treated group. On pathologic examination, a viable lesion was present in 12 (75%) rabbits in the control group and in 6 (38%) rabbits in the treated group (P = 0.073). The mean maximum thickness of viable tumor in the treated group was significantly smaller than that in the control group (0.74 mm vs. 3.39 mm; P = 0.02). Conclusions: Oral administration of TSU-68 augmented the effect of chemion of TSU-68 augmented the effect of chemotherapeutic infusion in a rabbit VX2 liver tumor model.

217

Transarterial Infusion Chemotherapy Using Cisplatin-Lipiodol Suspension With or Without Embolization for Unresectable Hepatocellular Carcinoma  

International Nuclear Information System (INIS)

We evaluate the long-term prognosis and prognostic factors in patients treated with transarterial infusion chemotherapy using cisplatin-lipiodol (CDDP/LPD) suspension with or without embolization for unresectable hepatocellular carcinoma (HCC). Study subjects were 107 patients with HCC treated with repeated transarterial infusion chemotherapy alone using CDDP/LPD (adjusted as CDDP 10mg/LPD 1ml). The median number of transarterial infusion procedures was two (range, one to nine), the mean dose of CDDP per transarterial infusion chemotherapy session was 30 mg (range, 5.0-67.5 mg), and the median total dose of transarterial infusion chemotherapy per patient was 60 mg (range, 10-390 mg). Survival rates were 86% at 1 year, 40% at 3 years, 20% at 5 years, and 16% at 7 years. For patients with >90% LPD accumulation after the first transarterial infusion chemotherapy, rates were 98% at 1 year, 60% at 3 years, and 22% at 5 years. Multivariate analysis identified >90% LPD accumulation after the first transarterial infusion chemotherapy (p = 0.001), absence of portal vein tumor thrombosis (PVTT; p < 0.001), and Child-Pugh class A (p = 0.012) as independent determinants of survival. Anaphylactic shock was observed in two patients, at the fifth transarterial infusion chemotherapy session in one and the ninth in the other. In conclusion, transarterial infusion chemotherapy with CDDP/LPD appears to be a useful treatment option for patients with unresectable HCC without PVTT and in Cith unresectable HCC without PVTT and in Child-Pugh class A. LPD accumulation after the first transarterial infusion chemotherapy is an important prognostic factor. Careful consideration should be given to the possibility of anaphylactic shock upon repeat infusion with CDDP/LPD.

218

Investigation on the pancreatic and stomach secretion in pigs by means of continuous infusion of 14C-amino acids  

International Nuclear Information System (INIS)

2 pigs received a barley-soya bean meal diet and another 2 a casein-wheat starch diet. The specific radioactivity (SR = dpm/?mol) of leucine and phenylalanine in the TCA soluble fraction of plasma and in the TCA soluble and TCA precipitable fractions of pancreatic juice and of digesta leaving the stomach was determined during 6 hours of intravenous infusion of 14C-leucine and 14C-phenylalanine. At the end of the infusion the SR of both amino acids in both fractions of several tissues was measured and used for calculations of the rate of tissue protein synthesis. The results are that mainly amino acids derived from the extracellular space were used for synthesis that the process of synthesis, concentration and secretion of secretory proteins requires in pigs 120 to 180 minutes, and that TCA soluble amino acids in pancreatic juice are not free amino acids per se, but originate from processing of presecretory proteins. In the duodenal digesta labelled proteins appeared 3 to 4 hours after the beginning of the infusion. Both, secretion of proteins by the pancreas and by the stomach seemed to be more stimulated after feeding the barley-soya diet than the casein-starch diet. Of all tissues, the SR of amino acids in proteins was highest in the pancreas. However, proteins secreted by the pancreas were 3 to 4 times higher labelled than those retained in the tissue. The range of the fractional rate of protein synthesis was calculated for the sections of the gastrointestinal tract, the liver and skeletal muscles and discussed with other findings. (author)

219

Dimensionnement d'un fuselage composite réalisé par infusion de résine = Numerical modeling of an aircraft composite fuselage manufactured by Liquid Resin Infusion  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Le projet FUSCOMP (FUSelage COMPosite) est un programme de Recherche & Développement qui a reçu la labellisation du pôle de compétitivité de l'Aerospace Valley. Il mènera d'ici 2011 au test d'un démonstrateur de fuselage composite réalisé par le procédé d'infusion de résine LRI (Liquid Resin Infusion). Ce procédé utilise une résine liquide infusée dans des tissus secs plutôt que des tissus préimprégnés, pour mettre en oeuvre des pièces en matériaux composites hautes perf...

Perret, Adrien; Mistou, Se?bastien; Denaud, Louis-etienne; Veyrac, Claudia; Molle?, Thierry; Karama, Moussa

2009-01-01

220

Effects of radiolabelled monoclonal antibody infusion on blood leukocytes in cancer patients  

International Nuclear Information System (INIS)

This study was undertaken to investigate the effects of a single infusion of radiolabelled murine monoclonal antibody (MAb) on peripheral blood leukocytes in cancer patients. Eleven patients with disseminated colon cancer, malignant melanoma, or lung adenocarcinoma were infused with 111In-labelled anti-ZCE 025, anti-p97 type 96.5c, or LA 20207 MAb, respectively. Blood samples were obtained before infusion, immediately after infusion (1 hr), and at 4 and 7 days postinfusion. Flow cytometry analysis of CD3+, CD4+, CD8+, CD16+, and CD19+ lymphocytes showed increasing CD4:CD8 ratios in seven patients after infusion. This phenomenon was not restricted to antibody subclass or to type of cancer. Two of the remaining patients exhibited a marked post-infusion increase in CD8+ cells. In all three patients with malignant melanoma, decreasing levels of CD16+ lymphocytes were noted after infusion and natural killer cell cytotoxicity showed fluctuations which paralleled the changes in the CD16+ subpopulation. Oxygen radical production by phagocytic cells was markedly affected in three subjects. These results suggest that a single infusion of radiolabelled murine MAb may alter the balance of critical lymphocyte subpopulations and modulate other leukocyte responses in cancer patients

 
 
 
 
221

Research into Teachers' Receptivity for Arts Infused Curricula in Taiwan  

Science.gov (United States)

The main purpose of this study was to understand the common attitudes and behaviours of teachers in Taiwan with regard to the implementation of arts infused curricula, as well as the individual problems these teachers encounter. From these results, we extracted reference data for the benefit of schools and policymakers in promoting arts infused

Giffen Cheng, Yueh Hsiu; Chou, Wen-Shou; Cheng, Chun Wen

2014-01-01

222

Precision flow-controlled rubidium-82 generator for bolus and constant infusion studies  

International Nuclear Information System (INIS)

A unique flow rate controller and large reservoir pumping system have been developed for infusing rubidium-82 intravenously at bolus, constant, or variable infusion rates. Using rubidium-82 and the positron ring detector tomograph, extraction or flow information can be obtained in studies of the heart, head, or kidneys

223

Pharmacology and therapeutic efficacy of bleomycin administered by continuous infusion  

International Nuclear Information System (INIS)

A study was done at Memorial Hospital in which Bleomycin was given by continuous intravenous infusion to radiation therapy patients with a variety of far advanced unresectable malignant neoplastic diseases. Smaller doses than usual were administered initially, approximately 1/10 the dose that had been previously studied. The dose was gradually escalated when it was shown that there was no acute toxicity from the smaller dose. Bleomycin blood levels were measured by bioassay and pulmonary function was studied by measurement of total lung capacity and carbon monoxide diffusing capacity. In this study, therapeutic activity in cervix cancer appeared to be significantly better than in earlier studies by the same group of investigators. However, in vitro and animal studies in the author's own clinical pharmacologic studies support the logic of continuous intravenous administration in the effort to decrease pulmonary toxicity and to improve therapeutic effect

224

Ist die subkutane Infusion eine praktische Alternative in der Geriatrie?  

Directory of Open Access Journals (Sweden)

Full Text Available In der Geriatrie hat das Thema der Flüssigkeitssubstitution einen besonderen Stellenwert - so verwundert es nicht, daß hauptsächlich Geriater die subkutane Infusion als Methode der Flüssigkeitszufuhr für ihre Patienten wiederentdeckten. Sie gilt heute als einfach, komplikationsarm, sicher und vor allem als für den Patienten schonend. Sie hat viele Vorteile und nur wenige Nachteile. Ihre Domäne ist die Vorbeugung von Dehydratation in Situationen, die dafür ein Risiko darstellen, sowie die Therapie von leichter bis mäßiger Dehydratation. Die bis vor wenigen Jahren, als neue Publikationen zu diesem Thema erschienen, archaisch anmutende Methode wurde jahrzehntelang kaum mehr angewandt und wenn, dann höchstens mit einem schlechten Gewissen und der Verzweiflung, keinen intravenösen Zugang gefunden zu haben. Sie schnitt auch hinsichtlich Sicherheit und Komplikationsrate im Vergleich zu den damals neu entwickelten Technologien und Materialien für den intravenösen Zugang schlechter ab. In einer kurzen Literaturübersicht wird über die Indikationen, Kontraindikationen und die Technik dieser wiederentdeckten Methode der Flüssigkeitssubstitution berichtet.

Frühwald T

2001-01-01

225

Intra-arterial infusion of prostaglandin EI in Buerger's disease  

International Nuclear Information System (INIS)

In Buerger's disease, arterial occlusion is so peripheral that reopening procedure such as reconstructive vascular surgery, percutaneous transluminal angioplasty and local fibrinolysis are not feasible, and major amputation is the only alternative. Prostaglandin E1, a potent vasodilator and inhibitor of platelet aggregation, has been used to treat the patients with severe arterial occlusive disease. In three cases of Buerger's disease, who are manifested by resting pain, non-healing ischemic ulcer, or impending gangrene and who were not candidates for direct arterial reconstructive procedure, we infused Prostaglandin El intraarterially at a fixed dosage to evaluate its effectiveness. We report our experience with the use of this drug in relieving the ischemic symptoms, healing the intractable ulcer, or avoiding the major amputation

226

Weekly paclitaxel infusion as salvage therapy in ovarian cancer.  

Science.gov (United States)

The majority of women diagnosed with epithelial ovarian cancer will have persistent or recurrent disease after initial treatment. We evaluated response and toxicity in women with advanced stage disease given salvage paclitaxel as a low-dose, weekly infusion. We performed a retrospective review of 22 women with advanced stage epithelial ovarian (19 women) or primary peritoneal carcinoma (3 women) who had received low-dose, weekly paclitaxel salvage therapy. All women had refractory, persistent, or recurrent disease following first-line treatment with paclitaxel and platin chemotherapy. Response and toxicity were assessed. Measurable disease present on physical or radiologic exam and serum carbohydrate antigen-125 levels were used to assess disease response. Overall response rate to low-dose, weekly paclitaxel salvage therapy was 50% (27% complete, 23% partial). Median progression-free interval (PFI) in responders was 27 weeks (range, 14-68 weeks). Stabilization of disease occurred in an additional 27% of patients with a median PFI of 22 weeks (range, 15-89 weeks). No difference in response was detected between the 7 women with platin-sensitive disease and the 15 women with platin-resistant disease (P = 0.19). The median dose of paclitaxel was 80 mg/m2 (range, 60-80 mg/m2). During a total of 325 weeks of paclitaxel treatment (median per patient, 12 weeks; range, 6-49 weeks), 13 treatment delays occurred (hematologic indication, 9; nonhematologic indication, 4). No cases of grade 4 hematologic toxicity, sepsis, or worsening neuropathy were documented. Weekly paclitaxel infusion given as salvage therapy results in significant clinical response, even in women previously treated with paclitaxel. The regimen is well tolerated with no cases of grade 4 neutropenia or worsening neuropathy in our population. PMID:14628424

Boruta, David M; Fowler, Wesley C; Gehrig, Paola A; Boggess, John F; Walton, Leslie A; Van Le, Linda

2003-01-01

227

Process Optimization of Bismaleimide (BMI) Resin Infused Carbon Fiber Composite  

Science.gov (United States)

Bismaleimide (BMI) resins are an attractive new addition to world-wide composite applications. This type of thermosetting polyimide provides several unique characteristics such as excellent physical property retention at elevated temperatures and in wet environments, constant electrical properties over a vast array of temperature settings, and nonflammability properties as well. This makes BMI a popular choice in advance composites and electronics applications [I]. Bismaleimide-2 (BMI-2) resin was used to infuse intermediate modulus 7 (IM7) based carbon fiber. Two panel configurations consisting of 4 plies with [+45deg, 90deg]2 and [0deg]4 orientations were fabricated. For tensile testing, a [90deg]4 configuration was tested by rotating the [0deg]4 configirration to lie orthogonal with the load direction of the test fixture. Curing of the BMI-2/IM7 system utilized an optimal infusion process which focused on the integration of the manufacturer-recommended ramp rates,. hold times, and cure temperatures. Completion of the cure cycle for the BMI-2/IM7 composite yielded a product with multiple surface voids determined through visual and metallographic observation. Although the curing cycle was the same for the three panellayups, the surface voids that remained within the material post-cure were different in abundance, shape, and size. For tensile testing, the [0deg]4 layup had a 19.9% and 21.7% greater average tensile strain performance compared to the [90deg]4 and [+45deg, 90deg, 90deg,-45degg] layups, respectively, at failure. For tensile stress performance, the [0deg]4 layup had a 5.8% and 34.0% greater average performance% than the [90deg]4 and [+45deg, 90deg, 90deg,-45deg] layups.

Ehrlich, Joshua W.; Tate, LaNetra C.; Cox, Sarah B.; Taylor, Brian J.; Wright, M. Clara; Caraccio, Anne J.; Sampson, Jeffery W.

2013-01-01

228

Haemolytic anaemia as a complication to intravenous immunoglobulin infusion  

DEFF Research Database (Denmark)

Intravenous immunoglobulin (IVIg) is an established treatment for various neuromuscular disorders. Recently, we have observed a few cases of haemolytic anaemia following IVIg treatment. The objective of this study was to determine the extent of anaemia and haemolysis as a complication to IVIg. In a prospective study we included 28 post-polio patients treated with 2g per kilo of Privigen® and 22 CIDP patients treated with 1.7±0.4 (mean±SD) g per kilo of Kiovig®. The post-polio patients were all IVIg treatment naitive whereas the CIDP patients were in maintenance therapy. Venous blood samples were performed before and two weeks after infusion of IVIg. Following treatment blood haemoglobin declined from 8.6±0.8 to 8.1±1.3mmol/l, p<0.001. Furthermore, decreasing haptoglobin and increasing reticulocyte count, blood bilirubin, and lactate dehydrogenase were observed, all p<0.05. The decrease of haemoglobin was 0.79±1.2 in the treatment naive versus 0.25±0.3mmol/l in the long-term treated patients, p=0.05. Alterations of reticulocyte count, haptoglobin and lactate dehydrogenase were more pronounced in the treatment naive group, all p<0.05. In 7 patients we observed a substantial decline of haemoglobin of more than 1.5mmol/l (1.8-2.9). Six of those 7 patients had undetectable levels of haptoglobin after IVIg and the mean reticulocyte count, blood bilirubin and lactate dehydrogenase increased 420%, 130% and 108%. All were in the de-novo treated group. Our observations indicate that treatment naive patients are susceptible to develop haemolysis. Haemolytic anaemia is a severe side effect that seems to be more frequent after immunoglobulin infusions than previously recognized.

Markvardsen, Lars HØj; Harbo, Thomas

229

Tolerance to cocaine in brain stimulation reward following continuous cocaine infusions.  

Science.gov (United States)

This study examined tolerance to cocaine's threshold-lowering effect in brain stimulation reward (BSR) following continuous cocaine infusions and secondly, used the nitric oxide synthase inhibitor N?-nitro-L-arginine methyl ester (L-NAME) to determine NO's involvement in the development of cocaine tolerance. Animals were continuously infused with saline or cocaine (30 mg/kg per day) via osmotic minipump for 14 days and injected daily with saline or L-NAME (30 mg/kg, i.p.) following BSR testing. Saline-treated animals continuously infused with saline showed stable BSR thresholds across the 14-day infusion period. Saline-treated animals continuously infused with cocaine showed markedly lowered BSR thresholds on Day 1 followed by a progressive increase in BSR thresholds across the infusion period - indicating the development of tolerance. L-NAME-treated animals continuously infused with cocaine showed stimulation thresholds that were not significantly different from saline-treated animals continuously infused with cocaine. A cocaine challenge injection (10 mg/kg, i.p.) administered 3 and again at 10 days following minipump removal revealed that saline-treated animals continuously infused with saline showed lowered BSR thresholds. Saline-treated animals continuously infused with cocaine displayed lowered BSR thresholds that were not significantly different from saline-infused animals. L-NAME treated animals continuously infused with cocaine showed higher BSR thresholds to a challenge 3 days following pump removal. However, stimulation thresholds for this group failed to reach statistical significance on both days (i.e., Days 3 and 10) following pump removal. Results showed that animals continuously infused with cocaine develop robust tolerance to cocaine's threshold-lowering effect during the 14-day infusion period. Tolerance to cocaine's threshold-lowering effect was short-lived and dissipated soon after minipump removal. L-NAME treatment failed to significantly alter the development of tolerance to cocaine's threshold-lowering suggesting that NO does not have a primary role in the development of cocaine tolerance. PMID:24768900

Pudiak, Cindy M; KuoLee, Rhonda; Bozarth, Michael A

2014-07-01

230

Adjacent central venous catheters can result in immediate aspiration of infused drugs during renal replacement therapy.  

Science.gov (United States)

Dual-lumen haemodiafiltration catheters enable continuous renal replacement therapy in the critically ill and are often co-located with central venous catheters used to infuse drugs. The extent to which infusions are immediately aspirated by an adjacent haemodiafiltration catheter remains unknown. A bench model was constructed to evaluate this effect. A central venous catheter and a haemodiafiltration catheter were inserted into a simulated central vein and flow generated using centrifugal pumps within the simulated vein and haemodiafiltration circuit. Ink was used as a visual tracer and creatinine solution as a quantifiable tracer. Tracers were completely aspirated by the haemodiafiltration catheter unless the infusion was at least 1 cm downstream to the arterial port. No tracer was aspirated from catheters infusing at least 2 cm downstream. Orientation of side ports did not affect tracer elimination. Co-location of central venous and haemodiafiltration catheters may lead to complete aspiration of infusions into the haemodiafilter with resultant drug under-dosing. PMID:22059378

Kam, K Y R; Mari, J M; Wigmore, T J

2012-02-01

231

Boron biodistribution in Beagles after intravenous infusion of 4-dihydroxyborylphenylalanine-fructose complex  

Energy Technology Data Exchange (ETDEWEB)

Boron biodistribution after intravenous infusion of 4-dihydroxyborylphenylalanine-fructose (BPA-F) complex was investigated in six dogs. Blood samples were evaluated during and following doses of 205 and 250 mg/kgbw BPA in a 30 min infusion, and 500 mg/kgbw in a 1 h infusion. Samples from whole blood, urine, brain and other organs were analysed for boron content after varying times following the onset of infusion. The whole blood boron concentrations declined from 27 to 8.4 ppm over the period of 39-165 min after the onset of infusion and the levels increased from 1.9 to 12 ppm in the grey matter of the brain over the same period. The boron concentrations in whole blood decreased steadily, whereas the boron values in brain tissue rose steadily with time. It was concluded that whole blood boron concentrations do not seem to reflect accurately the boron concentration in brain tissue at respective time points.

Kulvik, M.E. E-mail: martti.kulvik@welho.com; Vaehaetalo, J.K.; Benczik, J.; Snellman, M.; Laakso, J.; Hermans, R.; Jaerviluoma, E.; Rasilainen, M.; Faerkkilae, M.; Kallio, M.E

2004-11-01

232

Labetalol infusion for refractory hypertension causing severe hypotension and bradycardia: an issue of patient safety.  

Science.gov (United States)

Incremental doses of intravenous labetalol are safe and effective and, at times, such therapy may need to be augmented by a continuous infusion of labetalol to control severe hypertension. Continuous infusions of labetalol may exceed the recommended maximum daily dose of 300 mg on occasion. We report a case in which hypertension occurring after an abdominal aortic aneurysm repair, initially responsive to intermittent intravenous beta-blockade, became resistant to this therapy leading to the choice of an intravenous labetalol infusion as the therapeutic option. The labetalol infusion resulted in a profound cardiovascular compromise in this postoperative critically ill patient. While infusions of labetalol have successfully been used, prolonged administration in the intensive care unit requires vigilance and the establishment of a therapeutic rationale/policy for interventions, such as the ready availability of glucagon, beta-agonists, phosphodiesterase inhibitors, insulin, and vasopressin when severe cardiovascular depression occurs. PMID:18505576

Fahed, Samir; Grum, Daniel F; Papadimos, Thomas J

2008-01-01

233

Labetalol infusion for refractory hypertension causing severe hypotension and bradycardia: an issue of patient safety  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Incremental doses of intravenous labetalol are safe and effective and, at times, such therapy may need to be augmented by a continuous infusion of labetalol to control severe hypertension. Continuous infusions of labetalol may exceed the recommended maximum daily dose of 300 mg on occasion. We report a case in which hypertension occurring after an abdominal aortic aneurysm repair, initially responsive to intermittent intravenous beta-blockade, became resistant to this therapy leading to the choice of an intravenous labetalol infusion as the therapeutic option. The labetalol infusion resulted in a profound cardiovascular compromise in this postoperative critically ill patient. While infusions of labetalol have successfully been used, prolonged administration in the intensive care unit requires vigilance and the establishment of a therapeutic rationale/policy for interventions, such as the ready availability of glucagon, ?-agonists, phosphodiesterase inhibitors, insulin, and vasopressin when severe cardiovascular depression occurs.

Papadimos Thomas J

2008-05-01

234

Long-term BPA infusions. Evaluation in the rat brain tumor and rat spinal cord models  

Energy Technology Data Exchange (ETDEWEB)

In the BPA-based dose escalation clinical trial, the observations of tumor recurrence in areas of extremely high calculated tumor doses suggest that the BPA distribution is non-uniform. Longer (6-hour) i.v. infusions of BPA are evaluated in the rat brain tumor and spinal cord models to address the questions of whether long-term infusions are more effective against the tumor and whether long-term infusions are detrimental in the central nervous system. In the rat spinal cord, the 50% effective doses (ED{sub 50}) for myeloparesis were not significantly different after a single i.p. injection of BPA-fructose or a 6 hour i.v. infusion. In the rat 9L gliosarcoma brain tumor model, BNCT following 2-hr or 6-hr infusions of BPA-F produced similar levels of long term survival. (author)

Coderre, J.A.; Micca, P.L.; Nawrocky, M.M.; Joel, D.D. [Brookhaven National Laboratory, Medical Department, Upton, NY (United States); Morris, G.M. [University of Oxford, Research Institute, Oxford (United Kingdom)

2000-10-01

235

Successful intraosseous infusion in the critically ill patient does not require a medullary cavity.  

LENUS (Irish Health Repository)

OBJECTIVES: To demonstrate that successful intraosseous infusion in critically ill patients does not require bone that contains a medullary cavity. DESIGN: Infusion of methyl green dye via standard intraosseous needles into bones without medullary cavity-in this case calcaneus and radial styloid-in cadaveric specimens. SETTING: University department of anatomy. PARTICIPANTS: Two adult cadaveric specimens. MAIN OUTCOME MEASURES: Observation of methyl green dye in peripheral veins of the limb in which the intraosseous infusion was performed. RESULTS: Methyl green dye was observed in peripheral veins of the chosen limb in five out of eight intraosseous infusions into bones without medullary cavity-calcaneus and radial styloid. CONCLUSIONS: Successful intraosseous infusion does not always require injection into a bone with a medullary cavity. Practitioners attempting intraosseous access on critically ill patients in the emergency department or prehospital setting need not restrict themselves to such bones. Calcaneus and radial styloid are both an acceptable alternative to traditional recommended sites.

McCarthy, Gerard

2012-02-03

236

Determination of 210Po in tea, mat and their infusions and its annual intake by Syrians  

International Nuclear Information System (INIS)

Polonium-210 was determined in 34 kinds of imported tea and 9 kinds of mat collected from the Syrian local market. The 210Po concentration was found to vary from 5.5 to 39 Bq x kg-1 and 47 to 82 Bq x kg-1 in tea and mat samples, respectively. In addition 210Po was also determined in tea and mat infusions where different infusion conditions have been examined: amount, temperature and infusion time. The results have shown that the amount of 210Po transferred from tea and mat leaves to the aqueous extract ranged from 9 to 21% and 3 to 15%, respectively. The annual intake of 210Po by Syrians due to tea consumption and mat infusions was calculated and found to be 9 Bq and 151 Bq for tea and mat respectively: washing of mat with warm water is recommended before preparation the infusions to decrease the annual intake of 210Po. (author)

237

Artemisia absinthium and Artemisia vulgaris: a comparative study of infusion polysaccharides.  

Science.gov (United States)

The aerial parts of Artemisia absinthium and Artemisia vulgaris are used in infusions for the treatment of several diseases. Besides secondary metabolites, carbohydrates are also extracted with hot water and are present in the infusions. The plant carbohydrates exhibit several of therapeutic properties and their biological functions are related to chemical structure. In this study, the polysaccharides from infusions of the aerial parts of A. absinthium and A. vulgaris were isolated and characterized. In the A. absinthium infusion, a type II arabinogalactan was isolated. The polysaccharide had a Gal:Ara ratio of 2.3:1, and most of the galactose was (1 ? 3)- and (1 ? 6)-linked, as typically found in type II arabinogalactans. In the A. vulgaris infusion, an inulin-type fructan was the main polysaccharide. NMR analysis confirmed the structure of the polymer, which is composed of a chain of fructosyl units ?-(2 ? 1) linked to a starting ?-d-glucose unit. PMID:24507342

Corrêa-Ferreira, Marília Locatelli; Noleto, Guilhermina Rodrigues; Oliveira Petkowicz, Carmen Lúcia

2014-02-15

238

Evaluation of free radical scavenging activity of tea infusion of commercial tea products available in uae  

International Nuclear Information System (INIS)

In the present study, twenty four commercial tea samples were assayed to determine their free radical scavenging activity and polyphenolic contents based on the brewing/infusing period. Tea samples were infused/brewed in 200 mL boiled water at 120 degree C for 1, 2 and 5 min, respectively. The radical scavenging activities of tea infusion/brewing were measured using 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) assay method. The results were ranged from 67.81-90.51% for black tea bags, 90.37-94.51% for green tea bags, 24.66-92.25% for black tea powder, 16.08-93.06% for green tea powder and 32.90- 45.54% for Camomile herbal infusion. The results showed that 1 or 2 min black tea bags infusion exhibited highest radical scavenging activity than 5 min infusion. Antioxidant activities of tea powders were variable with the amount of tea powder. It was observed that antioxidant activity increased with increasing boiling time for smaller amount of sample. In contrary, shorter boiling time was better for larger amount of sample. The polyphenol contents of tea infusion were determined and the results were expressed as milligram quercetin equivalent/200 mL of tea infusion. The polyphenol content was increased with increased brewing period. In contrary, brewing for longer time rendered extract less antiradical activity. This study suggests that infusing tea bag for 1 or 2 min is sufficient for getting infusion with maximum radical scavenging activity and in case of tea powder, shorter boiling time is better for larger amount of powder or small amount of powder should be boiled for minimum 5 min for rendering extract with maximum radical scavenging activity. (author)

239

Systemic and regional hemodynamic effects of enalaprilat infusion in experimental normotensive sepsis  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english Angiotensin-converting enzyme inhibitors have been shown to improve splanchnic perfusion in distinct shock states. We hypothesized that enalaprilat potentiates the benefits of early fluid resuscitation in severe experimental sepsis, particularly in the splanchnic region. Anesthetized and mechanicall [...] y ventilated mongrel dogs received an intravenous infusion of live Escherichia coli over a period of 30 min. Thereafter, two interventions were performed: fluid infusion (normal saline, 32 mL/kg over 30 min) and enalaprilat infusion (0.02 mg kg-1 min-1 for 60 min) in randomized groups. The following groups were studied: controls (fluid infusion, N = 4), E1 (enalaprilat infusion followed by fluid infusion, N = 5) and E2 (fluid infusion followed by enalaprilat infusion, N = 5). All animals were observed for a 120 min after bacterial infusion. Mean arterial pressure, cardiac output (CO), portal vein blood flow (PVBF), systemic and regional oxygen-derived variables, and lactate levels were measured. Rapid and progressive reductions in CO and PVBF were induced by the infusion of live bacteria, while minor changes were observed in mean arterial pressure. Systemic and regional territories showed a significant increase in oxygen extraction and lactate levels. Widening venous-arterial and portal-arterial pCO2 gradients were also detected. Fluid replacement promoted transient benefits in CO and PVBF. Enalaprilat after fluid resuscitation did not affect systemic or regional hemodynamic variables. We conclude that in this model of normotensive sepsis inhibition of angiotensin-converting enzyme did not interfere with the course of systemic or regional hemodynamic and oxygen-derived variables.

L., Rahal; A.G., Garrido; R.J., Cruz Jr.; M., Rocha e Silva; L.F., Poli-de-Figueiredo.

1205-12-01

240

Species composition of bacterial communities influences attraction of mosquitoes to experimental plant infusions.  

Science.gov (United States)

In the container habitats of immature mosquitoes, catabolism of plant matter and other organic detritus by microbial organisms produces metabolites that mediate the oviposition behavior of Aedes aegypti and Aedes albopictus. Public health agencies commonly use oviposition traps containing plant infusions for monitoring populations of these mosquito species, which are global vectors of dengue viruses. In laboratory experiments, gravid females exhibited significantly diminished responses to experimental infusions made with sterilized white oak leaves, showing that attractive odorants were produced through microbial metabolic activity. We evaluated effects of infusion concentration and fermentation time on attraction of gravid females to infusions made from senescent bamboo or white oak leaves. We used plate counts of heterotrophic bacteria, total counts of 4',6-diamidino-2-phenylindole-stained bacterial cells, and 16S ribosomal DNA (rDNA) polymerase chain reaction-denaturing gradient gel electrophoresis (DGGE) to show that changes in the relative abundance of bacteria and the species composition of bacterial communities influenced attraction of gravid A. aegypti and A. albopictus mosquitoes to infusions. DGGE profiles showed that bacterial species composition in infusions changed over time. Principal components analysis indicated that oviposition responses to plant infusions were in general most affected by bacterial diversity and abundance. Analysis of bacterial 16S rDNA sequences derived from DGGE bands revealed that Proteobacteria (Alpha-, Beta-, Delta-, and Gamma-) were the predominant bacteria detected in both types of plant infusions. Gravid A. aegypti were significantly attracted to a mix of 14 bacterial species cultured from bamboo leaf infusion. The oviposition response of gravid mosquitoes to plant infusions is strongly influenced by abundance and diversity of bacterial species, which in turn is affected by plant species, leaf biomass, and fermentation time. PMID:19641948

Ponnusamy, Loganathan; Wesson, Dawn M; Arellano, Consuelo; Schal, Coby; Apperson, Charles S

2010-01-01

 
 
 
 
241

Renal damage induced by dosorubicin-lipiodol emulsion infused into rabbit renal artery : comparison with CT and histologic findings  

International Nuclear Information System (INIS)

The purpose of this study is to evaluate the utility of renal CT scanning and to histologically correlate renal damage induced by renal arterial infusion of 0.2 ml/kg of doxorubicin-lipiodol emulsion. Renal CT scans of 20 rabbit kidneys were obtained 15 days after transcatheter arterial chemoembolization and were classified into four grades, as follows: grade 0 - no fleck, grade 1 - one to three nodular flecks; grade 2 - four or more nodular flecks, or one semilunar fleck; and grade 3 - two or more semilunar flecks. The percentage of histological section occupied by lesion was determined using squared paper, and compared with the grades determined on the basis of CT. The histologic findings were interstitial inflammatory cell infiltration, intratubular lipiodol droplets, dystrophic calcification, and and cellular necrosis. The mean sizes of grade 0, 1, 2 and 3 histological lesions were 2.2 % (n=5), 4.5 % (n=4), 21.9 % (n=7), and 24% (n=4), respectively. Grades 0 and 1 accounted for nine cases (3.2%), while grades 2 and 3 accounted for 11 (22.6%); this difference was statistically significant (p<0.01). CT findings showing nodular or semilunar flecks 15 days after infusion into the renal artery of doxorubicin-lipiodol emulsion correlate with the size of the damaged kidney, as seen on histological specimens. (author). 19 refs., 3 tabs., 5 figs

242

Renal damage induced by dosorubicin-lipiodol emulsion infused into rabbit renal artery : comparison with CT and histologic findings  

Energy Technology Data Exchange (ETDEWEB)

The purpose of this study is to evaluate the utility of renal CT scanning and to histologically correlate renal damage induced by renal arterial infusion of 0.2 ml/kg of doxorubicin-lipiodol emulsion. Renal CT scans of 20 rabbit kidneys were obtained 15 days after transcatheter arterial chemoembolization and were classified into four grades, as follows: grade 0 - no fleck, grade 1 - one to three nodular flecks; grade 2 - four or more nodular flecks, or one semilunar fleck; and grade 3 - two or more semilunar flecks. The percentage of histological section occupied by lesion was determined using squared paper, and compared with the grades determined on the basis of CT. The histologic findings were interstitial inflammatory cell infiltration, intratubular lipiodol droplets, dystrophic calcification, and and cellular necrosis. The mean sizes of grade 0, 1, 2 and 3 histological lesions were 2.2 % (n=5), 4.5 % (n=4), 21.9 % (n=7), and 24% (n=4), respectively. Grades 0 and 1 accounted for nine cases (3.2%), while grades 2 and 3 accounted for 11 (22.6%); this difference was statistically significant (p<0.01). CT findings showing nodular or semilunar flecks 15 days after infusion into the renal artery of doxorubicin-lipiodol emulsion correlate with the size of the damaged kidney, as seen on histological specimens. (author). 19 refs., 3 tabs., 5 figs.

Kim, Jin Gyoo; Moon, Tae Young; Lee, Suck Hong; Kim, Byung Soo; Choi, Sang Yul; Park, Choong Hoon [Pusan National University Hospital, Pusan (Korea, Republic of)

1998-05-01

243

21 CFR 526.1696b - Penicillin G procaine-dihydrostreptomycin in soybean oil for intramammary infusion (dry cows).  

Science.gov (United States)

...false Penicillin G procaine-dihydrostreptomycin in soybean oil for intramammary infusion (dry cows). 526.1696b...1696b Penicillin G procaine-dihydrostreptomycin in soybean oil for intramammary infusion (dry cows). (a)...

2010-04-01

244

21 CFR 526.1696c - Penicillin G procaine-dihydrostreptomycin sulfate for intramammary infusion (dry cows).  

Science.gov (United States)

...procaine-dihydrostreptomycin sulfate for intramammary infusion (dry cows). 526.1696c...DRUGS, FEEDS, AND RELATED PRODUCTS INTRAMAMMARY DOSAGE FORMS § 526.1696c Penicillin...procaine-dihydrostreptomycin sulfate for intramammary infusion (dry cows). (a)...

2010-04-01

245

21 CFR 526.1696b - Penicillin G procaine-dihydrostreptomycin in soybean oil for intramammary infusion (dry cows).  

Science.gov (United States)

...2010-04-01 false Penicillin G procaine-dihydrostreptomycin in soybean oil for intramammary infusion (dry cows). 526.1696b...526.1696b Penicillin G procaine-dihydrostreptomycin in soybean oil for intramammary infusion (dry cows). (a)...

2010-04-01

246

Anti-Peroxyl Radical Quality and Antibacterial Properties of Rooibos Infusions and Their Pure Glycosylated Polyphenolic Constituents  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The anti-peroxyl radical quality of two aqueous rooibos infusions and solutions of their most abundant glycosylated polyphenols was evaluated using pyrogallol red and fluorescein-based oxygen radical absorbance ratios. It was observed that the artificial infusions, prepared using only the most abundant polyphenols present in rooibos and at concentrations similar to those found in the natural infusions, showed greater antioxidant quality than the latter infusions, reaching values close to thos...

Udekwu, Klas I.; Elizabeth Joubert; Eduardo Lissi; Baback Salehani; Akop Yepremyan; Minehan, Thomas G.; Camilo López-Alarcón; Nadja Karamehmedovic; Daisy Hjelmqvist; Simpson, Madeline J.; Alarcon, Emilio I.

2013-01-01

247

Bile duct complications of hepatic arterial infusion chemotherapy evaluated by helical CT  

Energy Technology Data Exchange (ETDEWEB)

AIM: To describe the imaging findings of bile duct complications of hepatic arterial infusion chemotherapy (HAIC) using helical CT, to set diagnostic criteria, to develop a CT grading system, and to correlate these with clinical findings and laboratory data. METHODS: Follow-up helical CT of the abdomen was performed every 3 months for 60 patients receiving HAIC. Three radiologists reviewed all CT studies before and after treatment, using either the picture archiving and communication system or hard copies. The findings of bile duct abnormalities were correlated with findings from other imaging techniques, clinical symptoms and laboratory data. RESULTS: Bile duct abnormalities developed in 34 (57%) of cases either during HAIC or 1 to 12 months after treatment. In 14 (41%) of these 34 patients, enhancement of the hepatic parenchyma along the dilated bile duct or in the segmental or lobar distribution was observed. In 43 cases (72%), normal or abnormal alkaline phosphatase levels were consistent with normal or abnormal CT findings, respectively. Increasing alkaline phosphatase and bilirubin levels were related to CT grade. CONCLUSION: Imaging findings of bile duct complications of HAIC are similar to those of primary sclerosing cholangitis, and correlate well with abnormal clinical and laboratory data. In the presence of such clinical abnormalities, thin-section helical CT with careful review of the imaging studies helps to determine the correct diagnosis, monitor the changes and guide appropriate treatment.

Phongkitkarun, S. [Department of Diagnostic Radiology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States)]. E-mail: rasih@mahidol.ac.th; Kobayashi, S. [Department of Diagnostic Radiology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Varavithya, V. [Department of Diagnostic Radiology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Huang, X. [Department of Biostatistics, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Curley, S.A. [Department of Surgical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Charnsangavej, C. [Department of Diagnostic Radiology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States)

2005-06-01

248

Bile duct complications of hepatic arterial infusion chemotherapy evaluated by helical CT  

International Nuclear Information System (INIS)

AIM: To describe the imaging findings of bile duct complications of hepatic arterial infusion chemotherapy (HAIC) using helical CT, to set diagnostic criteria, to develop a CT grading system, and to correlate these with clinical findings and laboratory data. METHODS: Follow-up helical CT of the abdomen was performed every 3 months for 60 patients receiving HAIC. Three radiologists reviewed all CT studies before and after treatment, using either the picture archiving and communication system or hard copies. The findings of bile duct abnormalities were correlated with findings from other imaging techniques, clinical symptoms and laboratory data. RESULTS: Bile duct abnormalities developed in 34 (57%) of cases either during HAIC or 1 to 12 months after treatment. In 14 (41%) of these 34 patients, enhancement of the hepatic parenchyma along the dilated bile duct or in the segmental or lobar distribution was observed. In 43 cases (72%), normal or abnormal alkaline phosphatase levels were consistent with normal or abnormal CT findings, respectively. Increasing alkaline phosphatase and bilirubin levels were related to CT grade. CONCLUSION: Imaging findings of bile duct complications of HAIC are similar to those of primary sclerosing cholangitis, and correlate well with abnormal clinical and laboratory data. In the presence of such clinical abnormalities, thin-section helical CT with careful review of the imaging studies helps to determine the correct diagnosis, monitor the chmine the correct diagnosis, monitor the changes and guide appropriate treatment

249

Effect of L-carnitine infusion and feed restriction on carnitine status in lactating Holstein cows.  

Science.gov (United States)

Previously we determined that abomasal infusion of L-carnitine increased in vitro hepatic fatty acid oxidation, decreased liver lipid accumulation, and supported higher fat-corrected milk yield in feed-restricted lactating cows. The objectives of this study were to examine the effects of supplemental L-carnitine and amount of feed intake on free carnitine and carnitine ester concentrations in liver, muscle, milk, and plasma of lactating dairy cows. Eight lactating Holstein cows (132 +/- 36 d in milk) were used in a replicated 4 x 4 Latin square design with 14-d periods to test factorial combinations of water or L-carnitine infusion (20 g/d; d 5 to 14) and ad libitum or restricted (50% of previous 5-d intake; d 10 to 14) dry matter intake. Plasma was obtained 3 times daily on d 4, 8, and 12; milk samples were collected on d 8, 9, 13, and 14. Liver and muscle were biopsied on d 14 of each period. Free carnitine, short-chain acylcarnitine, and long-chain acylcarnitine concentrations were determined using a radioenzymatic assay coupled with ion exchange chromatography. Abomasal L-carnitine infusion increased total carnitine in plasma on d 8 and d 12. All liver carnitine fractions were increased by carnitine infusion. Feed restriction elevated concentrations of free carnitine, long-chain acylcarnitine, and total carnitine in liver tissue from carnitine-infused cows but not in those infused with water. In muscle, acid-soluble carnitine, long-chain acylcarnitine, and total carnitine concentrations were increased by carnitine infusion and feed restriction without significant interaction. Feed restriction increased free carnitine concentrations in muscle from water-infused cows but not in carnitine-infused cows. Carnitine infusion increased the concentration of each milk carnitine fraction as well as milk carnitine output on d 8 to 9. On d 13 to 14, all carnitine fractions except short-chain acylcarnitine were increased in milk from water-infused, feed-restricted cows, whereas all fractions were increased in carnitine-infused, feed-restricted cows. Carnitine infusion increased total carnitine in plasma, liver, muscle, and milk during feed restriction, whereas feed restriction alone increased carnitine concentrations in muscle and milk but not in liver. Liver carnitine concentrations might limit hepatic fatty acid oxidation capacity in dairy cows during the periparturient period; therefore, supplemental L-carnitine might decrease liver lipid accumulation in periparturient cows. PMID:17430940

Carlson, D B; Woodworth, J C; Drackley, J K

2007-05-01

250

Evaluating the safety and efficiency of a CPOE system for continuous medication infusions in a pediatric ICU.  

Science.gov (United States)

Critically ill children often require continuous intravenous infusions of life-supporting medications. The complexity of ordering such infusions makes this an error prone process, and such errors can result in serious adverse events. A CPOE system was developed and evaluated to assess its impact on the safety and efficiency of prescribing continuous medication infusions. PMID:17238747

Vaidya, Vinay; Sowan, Azizeh K; Mills, Mary Etta; Soeken, Karen; Gaffoor, Mohamed; Hilmas, Elora

2006-01-01

251

C-Section  

Science.gov (United States)

C-Section Introduction A Cesarean section, or C-section, is the surgical delivery of a baby through ... the baby while recovering from surgery. After a C-Section The hospital stay after a C-section ...

252

Mechanism of delayed intracranial hypertension after cerebroventricular infusions in conscious rats  

Science.gov (United States)

Prior studies showed that cerebroventricular infusions of artificial cerebrospinal fluid, 8 microliter/min for 10 min, followed by a 10 min rest and a 24 h infusion of 0.5 microliters/min, raised cerebrospinal fluid pressure (CSFp) of conscious, unrestrained rats after about 2 h. Here, we report that the 10 min infusion alone evoked a delayed, prolonged rise in CSFp. Pressure during the infusion itself rose and recovered quickly, as is usually reported. Pressure/volume tests, used to calculate resistance to outflow (Ro) and compliance (C), revealed that infusions increased Ro and decreased C, after a delay (P less than 0.05). The rise in CSFp after infusion was blocked by pretreatment with acetazolamide + ouabain (P less than 0.05), but the delayed changes in Ro and C were unaffected. We suggest that the 10 min infusion of a sterile, balanced salt solution has a primary effect that increases Ro; as CSF synthesis continues, C is exhausted and the delayed rise in CSFp ensues. This non-traumatic method of raising CSFp may be a useful method to study intracranial fluid dynamics.

Morrow, B. A.; Holt, M. R.; Starcevic, V. P.; Keil, L. C.; Severs, W. B.

1992-01-01

253

Choice of infusion-sampling mode for tracer studies of free fatty acid metabolism  

International Nuclear Information System (INIS)

To determine the preferred infusion-sampling mode for isotopic studies of free fatty acid (FFA) metabolism, tracer [(14C]palmitate) was infused into the left ventricle of five anesthetized dogs, and tracee ([3H]palmitate) was infused into three separate peripheral veins of each dog. The [14C]palmitate specific activity (SA) was lower in mixed venous than arterial blood, and [3H]palmitate SA was equal in both sites. The actual infusion rate of [3H]palmitate [2.15 +/- 0.31 X 10(5) disintegrations/min (dpm).kg-1.min-1] could be accurately predicted (2.14 +/- 0.32 X 10(5) dpm.kg-1.min-1) using the known [14C]palmitate infusion rate and the arterial plasma [14C]-to-[3H]palmitate ratio. In contrast, the mixed venous [14C]-to-[3H]palmitate ratio resulted in overestimates (P less than 0.05) of the actual [3H]palmitate infusion rate. In summary, venous tracer infusion with arterial blood sampling for FFA tracer studies provides the most accurate estimates of tracee rate of appearance

254

Transfer of difenoconazole and azoxystrobin residues from chrysanthemum flower tea to its infusion.  

Science.gov (United States)

Investigations of the transfer of pesticide residues from tea to its infusion can be important in the assessment of the possible health benefits of tea consumption. In this work the transfer of difenoconazole and azoxystrobin residues from chrysanthemum tea to its infusion was investigated at different water temperatures, infusion intervals and times. The transfer percentages were in the range of 18.7-51.6% for difenoconazole and of 38.1-71.2% for azoxystrobin, and increased considerably with longer infusion intervals. The results indicated that azoxystrobin with a lower octanol-water partition coefficient of 2.5, showed a higher transfer than that of difenoconazole with a relatively high octanol-water partition coefficient of 4.4. Water temperature had no significant effect on the transfer of the two residues, and no obvious loss of difenoconazole and azoxystrobin occurred during the infusion process. The concentrations in the infusions decreased gradually from 0.67 to 0.30 ?g kg(-1) for difenoconazole and from 2.3 to 0.46 ?g kg(-1) for azoxystrobin after five infusions. To assess the potential health risk, the values of estimate expose risk were calculated to be 0.016 for difenoconazole and 0.0022 for azoxystrobin, meaning the daily residue intake of the two analytes from chrysanthemum tea was safe. This research may help assure food safety and identify the potential exposure risks from pesticides in chrysanthemum that may be health concerns. PMID:24405376

Xue, Jiaying; Li, Huichen; Liu, Fengmao; Xue, Jian; Chen, Xiaochu; Zhan, Jing

2014-04-01

255

Efficacy of hepatic arterial infusion chemotherapy in advanced hepatocellular carcinoma  

Directory of Open Access Journals (Sweden)

Full Text Available AIM: To investigate the efficacy of hepatic arterial infusion chemotherapy (HAIC using floxuridine (FUDR in patients with advanced hepatocellular carcinoma (HCC confined to the liver. METHODS: Thirty-four patients who had advanced HCC with unresectability or unsuccessful previous therapy in the absence of extrahepatic metastasis were treated with intra-arterial FUDR chemotherapy at our hospital between March 2005 and May 2008. Among the 34 patients, 9 patients were classified as Child class C, and 18 patients had portal vein tumor thrombus (PVTT. One course of chemotherapy consisted of continuous infusion of FUDR (0.3 mg/kg during day 1-14 and dexamethasone (10 mg on day 1, 4, 7 and 11, and this treatment was repeated every 28 d. RESULTS: Two patients (5.9% displayed a complete response, and 12 patients (35.3% had a partial response. The tumor control rate was 61.8%. The median overall survival times were 15.3 mo, 12.4 mo and 4.3 mo for the patients who were classified as Child class A, Child class B and Child class C, respectively (P = 0.0392. The progression-free survival was 12.9 mo, 7.7 mo and 2.6 mo for the patients who were classified as Child class A, Child class B and Child class C, respectively (P = 0.0443. The cumulative survival differed significantly according to the Child-Pugh classification and the presence of PVTT. In addition to hepatic reserve capacity and PVTT, the extent of HCC was an independent factor in determining a poor prognosis. The most common adverse reactions to HAIC were mucositis, diarrhea and peptic ulcer disease, but most of these complications were improved by medical treatment and/or a delay of HAIC. CONCLUSION: The present study demonstrates that intra-arterial FUDR chemotherapy is a safe and effective treatment for advanced HCC that is recalcitrant to other therapeutic modalities, even in patients with advanced cirrhosis.

Yang Hyun Baek

2012-01-01

256

Isotropic three-dimensional MRI-Fricke-infused gel dosimetry  

Energy Technology Data Exchange (ETDEWEB)

Purpose: Fricke-infused gel has been shown to be a simple and attainable method for the conformal measurement of absorbed radiation dose. Nevertheless, its accuracy is seriously hindered by the irreversible ferric ion diffusion during magnetic resonance imaging, particularly when three-dimensional (3D) dose measurement in radiosurgery is considered. In this study, the authors developed a fast three-dimensional spin-echo based Fricke gel dosimetry technique to reduce the adverse effects of ferric ion diffusion and to obtain an accurate isotropic 3D dose measurement. Methods: A skull shaped phantom containing Fricke-infused gel was irradiated using Leksell Gamma Knife. The rapid image-based dosimetry technique was applied with the use of a 3D fast spin-echo magnetic resonance imaging sequence. The authors mathematically derived and experimentally validated the correlations between dose-response characteristics and parameters of the 3D fast spin-echo MR imaging sequence. Absorbed dose profiles were assessed and compared to the calculated profiles given by the Gamma Knife treatment planning system. Coefficient of variance (CV%) and coefficient of determination (R{sup 2}) were used to evaluate the precision of dose-response curve estimation. The agreement between the measured and the planned 3D dose distributions was quantified by gamma-index analysis of two acceptance criteria. Results: Proper magnetic resonance imaging parameters were explored to render an accurate three-dimensional absorbed dose mapping with a 1 mm{sup 3} isotropic image resolution. The efficacy of the dose-response estimation was approved by an R{sup 2} > 0.99 and an average CV% of 1.6%. Average gamma pass-rate between the experimentally measured and GammaPlan calculated dose distributions were 83.8% and 99.7% for 2%/2 and 3%/3 mm criteria, respectively. Conclusions: With the designed MR imaging sequence and parameters, total 3D MR acquisition time was confined to within 20 min postirradiation, during which time ferric ion diffusion effects were negligible, thus enabling an accurate 3D radiation dose measurement.

Cho, Nai-Yu; Chu, Woei-Chyn [Institute of Biomedical Engineering, National Yang-Ming University, Taipei 11221, Taiwan (China); Huang, Sung-Cheng [Department of Molecular and Medical Pharmacology, UCLA David Geffen School of Medicine, Los Angeles, California 90095 (United States); Chung, Wen-Yuh [Neurological Institute, Taipei Veterans General Hospital, Taipei 11217, Taiwan (China); Guo, Wan-Yuo [Department of Radiology, Taipei Veterans General Hospital, Taipei 11217, Taiwan (China)

2013-05-15

257

Isotropic three-dimensional MRI-Fricke-infused gel dosimetry  

International Nuclear Information System (INIS)

Purpose: Fricke-infused gel has been shown to be a simple and attainable method for the conformal measurement of absorbed radiation dose. Nevertheless, its accuracy is seriously hindered by the irreversible ferric ion diffusion during magnetic resonance imaging, particularly when three-dimensional (3D) dose measurement in radiosurgery is considered. In this study, the authors developed a fast three-dimensional spin-echo based Fricke gel dosimetry technique to reduce the adverse effects of ferric ion diffusion and to obtain an accurate isotropic 3D dose measurement. Methods: A skull shaped phantom containing Fricke-infused gel was irradiated using Leksell Gamma Knife. The rapid image-based dosimetry technique was applied with the use of a 3D fast spin-echo magnetic resonance imaging sequence. The authors mathematically derived and experimentally validated the correlations between dose-response characteristics and parameters of the 3D fast spin-echo MR imaging sequence. Absorbed dose profiles were assessed and compared to the calculated profiles given by the Gamma Knife treatment planning system. Coefficient of variance (CV%) and coefficient of determination (R2) were used to evaluate the precision of dose-response curve estimation. The agreement between the measured and the planned 3D dose distributions was quantified by gamma-index analysis of two acceptance criteria. Results: Proper magnetic resonance imaging parameters were explored to render an accurate eters were explored to render an accurate three-dimensional absorbed dose mapping with a 1 mm3 isotropic image resolution. The efficacy of the dose-response estimation was approved by an R2 > 0.99 and an average CV% of 1.6%. Average gamma pass-rate between the experimentally measured and GammaPlan calculated dose distributions were 83.8% and 99.7% for 2%/2 and 3%/3 mm criteria, respectively. Conclusions: With the designed MR imaging sequence and parameters, total 3D MR acquisition time was confined to within 20 min postirradiation, during which time ferric ion diffusion effects were negligible, thus enabling an accurate 3D radiation dose measurement.

258

Proteolytic and proteomic changes in milk at quarter level following infusion with Escherichia coli lipopolysaccharide.  

Science.gov (United States)

Mastitis is a major disease in dairy cattle, which causes significant economic losses due to decreased milk production, veterinary costs, and discarded milk. Escherichia coli is one of the most prevalent species of gram-negative bacteria that induce clinical mastitis. The objective of the present study was to characterize the proteolytic and proteomic changes in milk in response to infusion with lipopolysaccharide (LPS) at quarter level in a model mastitis system. One quarter of each of 2 cows was infused with 0.1 or 5 ?g of LPS. The somatic cell count of the infused quarters reached a peak 6 h after infusion to a greater extent in the cow infused with 5 ?g of LPS and changes in plasmin activity in milk differed between the 2 animals. Urea-polyacrylamide gel electrophoretograms of milk samples of the cow infused with 5 ?g of LPS obtained at different time points after infusion and incubated for up to 7 d showed almost full hydrolysis of ?- and ?(s1)-casein during incubation of milk samples due to indigenous proteolytic activity. Two-dimensional gel electrophoretograms of milk at 0, 6, or 12 h after infusion with LPS showed hydrolysis of ?(s)-casein and ?-casein as well as the appearance of lower molecular weight products. Eleven fragments from proteolysis of the caseins were identified by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and, in addition, proteolysis patterns of casein by the indigenous bovine milk proteases plasmin and cathepsin D were studied in model studies using 2-dimensional gel electrophoretograms. Twelve hours after infusion, lower abundance markers of inflammation were identified, including serotransferrin, fibrinogen ? chain, protein S100 A12, and the antimicrobial polypeptide cathelicidin. PMID:22459814

Hinz, K; Larsen, L B; Wellnitz, O; Bruckmaier, R M; Kelly, A L

2012-04-01

259

Evaluation of efficacy and tolerability of fixed dose combination of ofloxacin with ornidazole infusion (infusion O2) in the management of diarrhoea and dysentery.  

Science.gov (United States)

Acute diarrhoea in adults is one of the most commonly encountered medical emergency in general practice and is responsible for considerable morbidity around the world. To evaluate the efficacy and tolerability of fixed dose combination of ofloxacin with ornidazole infusion (infusion O2) in the management of diarrhoea and dysentery, a study was carried out among 290 patients, age group from 18 to 65 years suffering from diarrhoea, dysentery, gastro-enteritis. Study drug infusion O2, (Medley Pharmaceutical, Mumbai) containing ofloxacin 200 mg + ornidazole 500 mg was administrated twice daily for a duration of 5 days. Number of soft or watery stool, body temperature, nausea, abdominal pain, gas and flatulence were recorded at baseline and at the end of the study. Tolerability and efficacy was evaluated based on the global assessment by the investigator based on a 3-point scale marked as excellent/good/poor. Two hundred and fifty-six-patients (160 male and 96 female) were included for final analysis, 34 patients lost to follow-up. Mean number of watery stool per day was reduced from 9.273 +/- 0.4537 to 1.375 +/- 0.07001 (p ornidazole infusion (infusion O2) significantly reduces number of watery stool and associated symptoms like nausea, abdominal pain, flatulence/gas with excellent tolerability. PMID:23029956

Faruqui, Arif A; Joshi, Chandrakant

2012-03-01

260

Visualization of the prediction of the results of the new technology infusion into road enterprise / ???????????? ???????? ??????????????? ??????????? ????????? ????? ?????????? ? ???????? ???????????  

Directory of Open Access Journals (Sweden)

Full Text Available The system for the visualization of the prediction process of new technology infusion into road enterprise on the basis of the production function type (PF is developed. Infusion is considered as the introduction to algebraic PF of some differentials dxi, i = 1,n, relative to the corresponding production factors xi (resources. Such formulation is determined by the necessity to implement the increment or reduction of resources when infusing new technology. The visualization allows you to visualize and choose the direction and content of the process of new technology introduction under real conditions of use of productive resources / ??????????? ??????? ???????????? ???????? ??????????????? ????????? ????? ?????????? ? ???????? ??????????? ?? ?????? ???????????????? ??????? (??. ????????? ??????????????? ??? ?????????????? ???????? ? ?? ????????? ?????????????? dxi, i = 1,n, ???????????? ??????????????? ???????????????? ???????? xi (????????. ????? ?????????? ??????????? ?????????????? ???????????? ?????????? ???? ?????????? ???????? ??? ????????? ????? ??????????. ???????????? ????????? ???????? ??????????? ? ??????? ??????????? ? ?????????? ???????? ????????? ????????????? ?????????? ? ???????? ???????? ????????????? ???????????????? ????????

Borovik Vitaly Sergeevich / ??????? ??????? ?????????

2014-03-01

 
 
 
 
261

Rescue therapy with terlipressin by continuous infusion in a child with catecholamine-resistant septic shock.  

Science.gov (United States)

A 2-month-old female infant presented with septic shock, refractory to high doses of catecholamines. Continuous infusion of terlipressin at a rate of 10 mcg/kgh produced a significant increase in the mean arterial pressure that was evident within half and hour, so allowing a reduction in the rate of catecholamine infusion. However, 18 h later, the blood pressure fell again and finally the patient died. This case shows the potential value of terlipressin infusion to restore normal mean arterial pressure in children with vasodilatory shock and hypotension refractory to catecholamines. PMID:16325320

Zeballos, Gonzalo; López-Herce, Jesús; Fernández, Carmen; Brandstrup, Kay B; Rodríguez-Núñez, Antonio

2006-01-01

262

Treatment of lung cancer with bronchial artery infusion of cisplatin and intravenous sodium thiosulfate rescue  

International Nuclear Information System (INIS)

Forty-nine patients with primary lung cancer were treated with bronchial artery infusion of cisplatin and intravenous injection of an antidote, sodium thiosulfate. More than 50% reduction of tumor size (PR) was observed in 8 of 9 small cell carcinomas (SCLC) and in 16 of 40 non-small cell carcinomas (NSCLC). In NSCLC patients PR was obtained in 71% (12/17) after repeated infusions (? 200 mg cisplatin) and in 17% (4/23) after a single infusion (? 150 mg cisplatin). There was a significant linear relationship between cisplatin dose and tumor reduction in this group. No severe adverse effects were encountered. (orig.)

263

Safe administration of iodine-131 tositumomab after repeated infusion-related reactions to rituximab.  

Science.gov (United States)

Infusion-related reactions during administration of monoclonal antibody therapy are often mild and unlikely to recur with subsequent treatment. If patients experience another severe reaction upon reattempting treatment, future treatments with the same agent are typically not pursued. It is unclear whether different monoclonal antibodies that bind the same tumor cell or antigen are likely to induce similar infusion reactions. Here, we report the case of a patient with repeated severe infusion reactions with rituximab who subsequently safely received treatment with iodine-131 tositumomab and discuss the relevant literature. PMID:17405899

Hayslip, John; Fenning, Robert

2007-03-01

264

Changes in circulating blood volume after infusion of hydroxyethyl starch 6% in critically ill patients  

DEFF Research Database (Denmark)

The cardiovascular response to a volume challenge with hydroxyethyl starch (HES) (200/0.5) 6% depends on the relation between the volume of HES 6% infused and the expansion of the blood volume in critically ill patients. However, only relatively limited data exist on the plasma expanding effect of infusion of HES 6% in critically ill patients. The purpose of the study was to evaluate the variation in the expansion of the circulating blood volume (CBV) in critically ill patients after infusion of 500 ml of colloid (HES (200/0.5) 6%) using the carbon monoxide method.

Christensen, P; Andersson, J

2001-01-01

265

MR angiography of low limb artery with a moving-bed infusion-tracking technique in diabetes  

International Nuclear Information System (INIS)

Objective: To explore the diagnostic value of MPA with a moving-bed infusion-tracking technique in lower limb arterial disease of diabetic patients. Methods: MPA of low limb artery in 21 diabetes patients were analyzed. And the results were compared with that of DSA. Results: 16 cases were excellent MR imaging and 5 were good. In 10 sections of low limb artery, 29 stenosis were displayed by MPA and 36 by DSA. The total accordance rate was 80.6% There was no statistically significant difference between MRA and DSA in the diagnosis of stenosis. Conclusion: MPA was a reliable method and non-invasive method with excellent correlation between MRA and DSA in the diagnosis of' arterial stenosis. (authors)

266

A Review of the Security of Insulin Pump Infusion Systems  

Energy Technology Data Exchange (ETDEWEB)

Insulin therapy has enabled diabetic patients to maintain blood glucose control to lead healthier lives. Today, rather than manually injecting insulin using syringes, a patient can use a device, such as an insulin pump, to programmatically deliver insulin. This allows for more granular insulin delivery while attaining blood glucose control. The insulin pump system features have increasingly benefited patients, but the complexity of the resulting system has grown in parallel. As a result security breaches that can negatively affect patient health are now possible. Rather than focus on the security of a single device, we concentrate on protecting the security of the entire system. In this paper we describe the security issues as they pertain to an insulin pump system that includes an embedded system of components including the insulin pump, continuous glucose management system, blood glucose monitor, and other associated devices (e.g., a mobile phone or personal computer). We detail not only the growing wireless communication threat in each system component, but we also describe additional threats to the system (e.g., availability and integrity). Our goal is to help create a trustworthy infusion pump system that will ultimately strengthen pump safety, and we describe mitigating solutions to address identified security issues both for now and in the future.

Klonoff, David C. [Mills-Peninsula Health Services; Paul, Nathanael R [ORNL; Kohno, Tadayoshi [University of Washington, Seattle

2011-01-01

267

Interdisciplinary committee on infusion-control devices: evaluating new products.  

Science.gov (United States)

Evaluation and selection of volumetric infusion-control devices (ICDs) by an interdisciplinary committee in a university teaching hospital is described. The committee, which was originally formed to evaluate problems with the existing system of ICD management, determined that the ICDs in use at the hospital were outdated. After gathering information on the types of ICDs available and identifying options for replacing the existing equipment, the committee decided to replace some of the devices with new volumetric ICDs. A six-page evaluation form was mailed to ICD manufacturers, and representatives from 16 manufacturers were invited to demonstrate their devices to the committee members. Five manufacturers were then invited to participate in a two-week, inhouse comparative trial, during which the devices were objectively evaluated by nurses, the bioinstrumentation department, and the ICD committee. The results of that evaluation were used to construct bid specifications. The decision of which ICDs to purchase was based on cost factors and the degree to which the devices met the specifications. The use of a multidisciplinary committee to evaluate and select new ICDs was an effective strategy. The devices that were purchased represented improvements in patient safety and cost-effectiveness. PMID:3369463

Donnelly, E B; Witte, K W; Eck, T A; LaPlume, G

1988-03-01

268

Interdisciplinary committee on infusion-control devices: managing product use.  

Science.gov (United States)

The development of an interdisciplinary approach to the management of infusion-control devices (ICDs) in a university teaching hospital is described. An ICD committee composed of staff from the pharmacy, nursing, bioinstrumentation, and materiel management departments was created to identify and solve problems with the existing system of ICD management. These problems included untimely delivery of malfunctioning ICDs to the bioinstrumentation department for repairs, chronic shortages of ICDs, inappropriate use of these devices, and lost charges for ICDs and cassettes. The committee decided on joint control of the ICD program by the pharmacy and nursing departments. Guidelines for appropriate use of ICDs were developed and distributed to all nursing units and pharmacy satellites. The pharmacist was responsible for screening requests for ICDs to determine whether they conformed to those guidelines. New policies for delivery of malfunctioning ICDs to the bioinstrumentation department resulted in improved turnaround time for repairs. Responsibility for billing was shared by the pharmacy and nursing departments. These changes resulted in increased availability of ICDs for patient use and an increased charge capture of $247,000 per year. Through the combined efforts of the pharmacy and nursing departments in this institution, the distribution and collection of ICDs has been made more efficient and lost patient charges have decreased. PMID:3285674

Donnelly, E B; Witte, K W; LaPlume, G

1988-03-01

269

Changes in regional plasma extravasation in rats following endotoxin infusion  

International Nuclear Information System (INIS)

Regional differences in plasma extravasation during endotoxin shock in rats and a possible relationship with changes in regional blood flow were studied with radioactive isotopes (125I-HSA, 51Cr-labeled red blood cells, microspheres) in anesthetized rats (pentobarbital). Shock was induced by intravenous infusion of endotoxin (Eschericia coli; 10 mg X kg-1) for 60 min (starting at t = 0); at t = 120 min, the experiments were terminated. These rats (n = 8) were compared with time-matched control rats (n = 8). A third group (rats killed 7.5 min after injection of 125I-HSA, i.e., no extravasation; n = 8) served as baseline. The amount of plasma extravasated in 2 hr of endotoxin shock was significantly increased over control values in skin (by 67%), colon (88%), skeletal muscle (105%), stomach (230%), pancreas (300%), and diaphragm (1300%). Losses of 125I-HSA into intestinal lumen and peritoneal cavity had also increased over control values by 146 and 380%, respectively. Blood flow was compromised in most organs except heart and diaphragm. Extravasation when normalized for total plasma supply was correlated with total blood supply; the more the blood supply decreased, the higher the normalized extravasation. In the diaphragm, however, blood supply and plasma leakage increased together. Decreased blood supply and plasma extravasation may be related but they could also be simultaneously occurring independent phenomena with a common origin

270

Hepatic Arterial Infusion Chemotherapy for Advanced Hepatocellular Carcinoma in Japan  

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Full Text Available Transcatheter methods such as transcatheter arterial chemoembolization (TACE and hepatic arterial infusion chemotherapy (HAIC have an important role in the treatment for advanced hepatocellular carcinoma (HCC. Recently, sorafenib, an inhibitor of tyrosine kinases, has been found to obtain survival benefits in patients with HCC, leading to major advances in the treatment of advanced HCC. However, it is associated with a low tumor response rate, minimal survival advantage, and high rates of adverse events. On the other hand, high rates of objective treatment response with HAIC for advanced HCC have been reported, although convincing evidence of it contributing to overall survival in HAIC has been lacking. In Japan, HAIC still tends to be the preferred method for the treatment of advanced HCC, even in patients with poor liver function. However, the choice of chemotherapeutic agents in TACE/HAIC for HCC varies between institutions. In this review, based on studies reported to date in the literature, we refer to current knowledge regarding the chemotherapeutic agents used for TACE/HAIC for HCC in Japan and consider the future perspectives for HAIC for this cancer.

Ryuichi Kita

2012-02-01

271

Radiation resistance of microorganisms on unsterilized infusion sets  

DEFF Research Database (Denmark)

Three different methods were used for detecting and isolating microorganisms with high radiation resistance from the microbial contamination on infusion sets prior to sterilization. By all three methods, microorganisms with a radiation resistance high enough to be a critical factor in a sterilization process (D-6 value greater-than-or-equal-to 30 kGy) were found with a frequency of approximately two colony forming units (cfu) per 100 product items, even though the product items in two of the series of analyses were irradiated with doses of 3-6 kGy. The frequency of occurrence of isolates with D-6 values greater-than-or-equal-to 30 kGy was 0.45 per 1000 cfu of the total aerobic count. Eight different isolates of microorganisms had D-6 values greater-than-or-equal-to 40 kGy when irradiated in dried laboratory preparation. All but one of these were classified according to morphologic criteria as Deinococcus, and all but one had nonlinear dose-response relationships in semilogarithmic presentation.

Miller, A.

1991-01-01

272

Sequential infusion of donor-derived dendritic cells with donor lymphocyte infusion for relapsed hematologic cancers after allogeneic hematopoietic stem cell transplantation.  

Science.gov (United States)

Donor lymphocyte infusion (DLI) is often given to induce a graft-versus-leukemia (GVL) effect after allogeneic hematopoietic stem cell transplantation (HSCT). However, efficacy of DLI is limited in most hematologic cancers. As antigen presenting cells, dendritic cells (DC) bolster immune responses. We conducted a Phase I trial testing the coinfusion of DC followed by DLI. DC were generated by culturing peripheral blood mononuclear cells from HLA matched-related donors in GM-CSF and IL-4 for 7 days, followed by TNF-? for 3 days. DC were administered intravenously on 3 dose levels (5 × 10(6) ; 1 × 10(7) ; 5 × 10(7) cells). DLI (3 × 10(7) CD3+ cells/kg) was administered intravenously 1 day after the DC. Sixteen patients with hematologic cancers relapsed after HSCT were treated. A maximum tolerated dose for DC was not reached. Two of 16 patients met criteria for DLT within 10 weeks of the infusion: 1 idiopathic respiratory failure, 1 ventricular cardiac arrest. None developed grade III/IV GVHD. One patient developed grade II acute intestinal graft-vs.-host disease (GVHD) and 1 chronic GVHD within 6 months of the infusion. Both resolved with corticosteroids. Four of 14 patients evaluable for disease response achieved durable remissions and are alive and cancer free 6.7, 8.4, 8.8, and 10.1 years from infusion. Sequential infusion of donor-derived DC with DLI is feasible in patients with relapsed hematologic cancers after allogeneic HSCT. Future studies may consider donor DC preloaded with tumor antigens to investigate whether DC infusion could augment the GVL effect. Am. J. Hematol. 89:1092-1096, 2014. © 2014 Wiley Periodicals, Inc. PMID:25132538

Ho, Vincent T; Kim, Haesook T; Kao, Grace; Cutler, Corey; Levine, James; Rosenblatt, Jacalyn; Joyce, Robin; Antin, Joseph H; Soiffer, Robert J; Ritz, Jerome; Avigan, David; Alyea, Edwin P

2014-12-01

273

Anti-Peroxyl Radical Quality and Antibacterial Properties of Rooibos Infusions and Their Pure Glycosylated Polyphenolic Constituents  

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Full Text Available The anti-peroxyl radical quality of two aqueous rooibos infusions and solutions of their most abundant glycosylated polyphenols was evaluated using pyrogallol red and fluorescein-based oxygen radical absorbance ratios. It was observed that the artificial infusions, prepared using only the most abundant polyphenols present in rooibos and at concentrations similar to those found in the natural infusions, showed greater antioxidant quality than the latter infusions, reaching values close to those reported for tea infusions. Additionally, the antimicrobial activity of the natural and artificial infusions was assessed against three species of bacteria: Gram (+ Staphylococus epidermidis and Staphylococcus aureus and Gram (? Escherichia coli. When compared to the natural infusions the artificial beverages did not demonstrate any bacterostatic/cidal activity, suggesting that the antibacterial activity of rooibos is related to compounds other than the glycosylated polyphenols employed in our study.

Klas I. Udekwu

2013-09-01

274

Anti-peroxyl radical quality and antibacterial properties of rooibos infusions and their pure glycosylated polyphenolic constituents.  

Science.gov (United States)

The anti-peroxyl radical quality of two aqueous rooibos infusions and solutions of their most abundant glycosylated polyphenols was evaluated using pyrogallol red and fluorescein-based oxygen radical absorbance ratios. It was observed that the artificial infusions, prepared using only the most abundant polyphenols present in rooibos and at concentrations similar to those found in the natural infusions, showed greater antioxidant quality than the latter infusions, reaching values close to those reported for tea infusions. Additionally, the antimicrobial activity of the natural and artificial infusions was assessed against three species of bacteria: Gram (+) Staphylococus epidermidis and Staphylococcus aureus and Gram (-) Escherichia coli. When compared to the natural infusions the artificial beverages did not demonstrate any bacterostatic/cidal activity, suggesting that the antibacterial activity of rooibos is related to compounds other than the glycosylated polyphenols employed in our study. PMID:24036515

Simpson, Madeline J; Hjelmqvist, Daisy; López-Alarcón, Camilo; Karamehmedovic, Nadja; Minehan, Thomas G; Yepremyan, Akop; Salehani, Baback; Lissi, Eduardo; Joubert, Elizabeth; Udekwu, Klas I; Alarcon, Emilio I

2013-01-01

275

Variation of the intercellular space in the esophageal epithelium in response to hydrochloridric acid infusion in patients with erosive esophagitis  

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Full Text Available The purpose of this study was to compare esophageal infusion with 0.1 N hydrochloridric acid (HCl to esophageal infusion with saline in patients presenting with typical gastroesophageal reflux symptoms and erosive esophagitis. METHODS: Upper gastrointestinal endoscopy was performed on 44 prospective subjects, 29 of whom were included in the study. Eighteen patients presented with normal esophagi (Control Group "C", nine of whom were infused with HCl and nine with saline. Eleven patients presented with erosive esophagitis (Lesion Group "L", five of whom were infused with HCl and six with saline. Biopsies of the esophageal mucosa were collected before and after infusions. RESULTS: No statistically significant difference was found between the two types of infusions in terms of the dilation of the intercellular space of the esophageal epithelium, regardless of the status of the patient. CONCLUSIONS: Response to HCl infusion cannot be used as a marker for gastroesophageal reflux disease.

Ricardo Tedeschi Matos

2009-01-01

276

A technique of infusion of contrast material on CT enhancement study  

International Nuclear Information System (INIS)

We have studied the method of enhancement on a fast CT scanner of the third generation by changing the infusion time of contrast material, 3 min., 5 min. and 7 min., and by measuring the attenuation values of certain ROIs at 1 min., 3 min. and 5 min. after infusion. 60% meglumine iothalamate and 65% meglumine diatrizoate were compared in their enhancing effect and side effects. There was no difference in the enhancing effect between the two contrast materials, but 60% meglumine iothalamate had less side effect than the other. The longer the infusion time, the less the side effects, especially nausea and vomiting. We have come to the conclusion that 7 min. infusion of 100 ml of 60% meglumine iothalamate is the method of choice for contrast enhancement CT scan. (author)

277

Altered hepatic vasopressin and alpha 1-adrenergic receptors after chronic endotoxin infusion  

International Nuclear Information System (INIS)

Sepsis and septic shock are complicated by a number of hemodynamic and metabolic aberrations. These include catecholamine refractoriness and altered glucose metabolism. Recently, a nonshock rat model of continuous endotoxin infusion via an implanted osmotic pump was developed that reproduces some of the metabolic and cardiovascular findings of human sepsis. By using this model, we have found a decreased number of hepatic plasma membrane alpha 1-adrenergic and [Arg8]vasopressin receptors in rats continuously infused with endotoxin. There was a significant decrease in [3H]prazosin (35 +/- 7%) and [3H] [Arg8]vasopressin (43 +/- 8%) receptors after 30 h of continuous endotoxin infusion with no change in affinity. The ability of norepinephrine to form the high-affinity complex with alpha 1-adrenergic receptors was not altered after chronic endotoxin infusion. The results are consistent with the concept that alterations in receptor number might underlie certain of the metabolic consequences of chronic sepsis

278

Hemodynamic effects of rapid and slow infusions of manganese chloride and gadolinium-DTPA in dogs  

International Nuclear Information System (INIS)

The acute hemodynamic effects of two paramagnetic contrast materials, manganese chloride and gadolinium-DTPA, were examined in dogs using ultrasonic dimension gauge crystals. Slow infusions (more than 15 minutes) of MnCl2 or Gd-DTPA via an infusion pump had no significant hemodynamic effects. When given in just over 1 minute, Gd-DTPA produced elevated left ventricular (LV) end diastolic pressure and minor dilation of the ventricle and slowed diastolic filling. MnCl2, given rapidly, reduced systemic vascular resistance, resulting in hypotension. With both agents, these side effects waned after 5-10 minutes. It is concluded that both Gd-DTPA and MnCl2 can be given safely in 0.1-mm/kg doses when administered as a slow, continuous infusion. Slow, intravenous infusion of Gd-DTPA or MnCl2 is likely to be tolerated well by even severely ill individuals

279

Continuous subcutaneous insulin infusion in type 1 diabetic Saudi children. A comparison with conventional insulin therapy.  

Directory of Open Access Journals (Sweden)

Continuous subcutaneous insulin infusion improved the glycemic control in diabetic Saudi children with decreased frequency of hypoglycemic episodes and DKA events. Long follow-up studies are needed to confirm these results.

Bassam S. Bin-Abbas

2005-06-01

280

E-Commerce Infusion into Business Education--Encompassing the Realities of an Emerging Business Model.  

Science.gov (United States)

A survey of 287 business faculty found that few were infusing electronic commerce topics into existing curricula despite its growing use in business. Responses were similar regardless of faculty gender, region, and program size or level. (SK)

Morrison, James L.; Oladunjoye, Ganiyu Titi

2002-01-01

 
 
 
 
281

Efficacy of Synthetic Insecticide and Botanical Infusions Against Onion Thrips in Balochistan, Pakistan-I  

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Full Text Available A synthetic insecticide (Monocrotophos 40WSL and three botanical infusions (Datura alba Seed Extract Infusion, SEI; Calotropis procera Latex Infusion, LI and Citrullus colocynthus Fruit Extract Infusion, FEI were tried against onion thrips on broadcasted onion variety “Chlitan 89” in Quetta, Pakistan. All tested insecticides caused mortality of onion thrips at various degrees of significance over untreated control. C. procera LI, proved it self the best among the tested botanical insecticides and provided 42.67 % control after Monocrotophos that caused 76.24 % mortality of onion thrips. D. alba SEI and C. colocynthus FEI showed minimal control (17.23 and 6.77 % respectively of the said pest than other tested insecticides but the results encourage the idea of pollution free methods of pest control. The C. procera LI can be used as good as any other botanical insecticide in Integrated Pest Management (IPM of onion thrips.

Muhammad Faheem Malik

2003-01-01

282

In vitro study of the antioxidant and immunomodulatory activity of aqueous infusion of Bidens pilosa.  

Science.gov (United States)

Bidens pilosa is an annual plant from tropical America with anti-inflammatory properties in hepatitis, laryngitis, headache and digestive disorders, among others. Its wide pharmacological applications can be attributed to its chemical composition, with inhibitory effects on pathogenic microorganisms and flavonoids, which show strong antioxidant capacities. We investigated the antioxidant activity of an aqueous infusion of Bidens pilosa by studying its protective effect on the hemolysis induced by an initiator of radicals such as 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH). The immunomodulatory activity of the infusion was tested using whole blood cells. Cytokine production increased in whole blood stimulated or not by lipopolysaccharides (LPSs). The infusion is also characterized by its capacity to protect erythrocytes from the phototoxic effect of chlorpromazine, which allows its use as a potential photoprotector. Finally, it did not show ocular irritation, as demonstrated by the effect on hemoglobin denaturation. This study supports the health benefits of the ingestion of the infusion. PMID:15234771

Abajo, Celia; Boffill, María Angeles; del Campo, Jaime; Alexandra Méndez, María; González, Yisel; Mitjans, Montserrat; Pilar Vinardell, María

2004-08-01

283

[Antenatal ethanol-fructose infusion for prophylaxis of dyspnoea (author's transl)].  

Science.gov (United States)

The incidence of dyspnoea among immature newborns, delivered after pregancy periods between 28 and 32 weeks, was reduced with statistically secured significance by antepartal intravenous administration of fructose-ethanol infusions to the mother. PMID:547611

Lauckner, W; Retzke, U

1979-01-01

284

Isolated tubercular liver abscess in children treated with percutaneous isoniazid infusion.  

Science.gov (United States)

Isolated Tubercular liver abscess is mainly reported in adult patients. We report two cases of isolated tubercular liver abscess in paediatric patients. Diagnosis was made by clinical and ultrasound guided aspiration of pus showing acid fast bacilli in one case. In second case, biopsy of the abscess wall was confirmatory. In both cases percutaneous drainage of pus and transcatheter infusion of Isoniazid was given. After two weeks of infusion no acid fast bacilli was detected and cavity size decreased. Direct infusion of anti-tubercular drugs is more efficient than systemic therapy alone. This is first of its kind in treating isolated tubercular abscess in paediatric patients. So, percutaneous infusion of anti-tubercular agents can be considered in the treatment of tubercular liver abscess. PMID:17886705

Debnath, Pinaki R; Tripathi, Rakesh; Kandpall, Deepak; Kumar, Basant; Malik, Ekta; Sharma, Shyam B

2007-07-01

285

Determination of mineral and trace elements in some medicinal herbs and their infusions consumed in Turkey.  

Science.gov (United States)

Fourteen mineral and trace elements (Al, Ba, Ca, Cd, Co, Cr, Cu, Fe, Mg, Mn, Ni, Pb, Sr and Zn) were determined in the herbs and their infusions consumed for medical purposes in Turkey such as chamomile (Matricaria chammomile L.), fennel (Foeniculum vulgare), linden (Tilia vulgaris), nettle (Urtica dioical), rosehip (Fr.Rosa caninae), sage (Salvia officinalis) and senna tea (Cassia anqustifolia). Microwave digestion procedure was applied under optimized conditions for dissolution of medicinal herbs. Element concentrations in the medicinal herbs and their infusions were determined by FAAS and ICP-AES. The accuracy and precision were verified against a GBW 07605 Poplar leaves and Tea certified reference material. The mineral and trace element content of medicinal herbs and their infusions showed a wide variability. However, distribution of the elements in the infusions is not high and it is nil especially for Cd, Co, Cr and Pb. PMID:15907975

Ba?gel, S; Erdemo?lu, S B

2006-04-15

286

[Prolonged epidural infusion of ropivacaine in the complex of anesthesiological protection at pancreatoduodenal surgery].  

Science.gov (United States)

The purpose of this study was to examine the expediency and efficiency of use of an infusion administration of naropine into the epidural space for intraoperative anesthesia and to develop the optimum procedure for administering this anesthetic during operations on the upper abdomen. Studies were performed in 43 patients operated on for different pancreatic diseases. Anesthesia based on epidural naropine infusion versus ataralgesia was compared. This study indicated that epidural naropine infusion-based anesthesia provides stable hemodynamic parameters and reduces the use of narcotic analgesics by more than twice. Inclusion of prolonged epidural infusion of 0.3% naropine solution into the anesthesiological appliance scheme during this type of operations provides an adequate antinociceptive protection and contributes to the early activation of patients, which prevents the development of postoperative complications. PMID:15938092

Mironenko, A V; Ovezov, A M; Petrov, O V

2005-01-01

287

Elimination of infused arginine-vasopressin and its long-acting deaminated analogue in rats  

International Nuclear Information System (INIS)

Argenine-vasopressin (AVP) and deamino-argenine-vasopressin (dAVP) were infused into rats. When the concentration of two peptides were steady the rate of clearance of AVP from the plasma was six times the rate of clearance of dAVP. Only 6% of the infused AVP was excreted unchanged in the urine, whereas approximately 100% of the dAVP was excreted. When the infusions were stopped, AVP disappeared from the plasma much more rapidly than dAVP. The plasma concentrations of the two peptides did not decay as simple exponential functions, suggesting that both AVP and dAVP entered a slowly exchanging compartment or compartments during prolonged infusion. These differences in the metabolic clearance of AVP and dAVP may well explain the prolonged antidiuretic effect of dAVP in rats. (author)

288

Modeling and experimental verification of infusion speed of liquids in photonic crystal fibers  

DEFF Research Database (Denmark)

A theoretical method for predicting infusion time of liquids in microcapillaries is formulated. Through a microscopical, a fluorescent, and, finally, through a reflectometric measurement method, the model is successfully verified in real photonic crystal fibers.

Noordegraaf, Danny; Bjarklev, Anders Overgaard

289

Positron emission tomography and target-controlled infusion for precise modulation of brain drug concentration  

International Nuclear Information System (INIS)

a corresponding to a whole-brain concentration of 107±7 ng/ml was rapidly achieved. Conclusion: The experimental setup with computerized pump infusion and PET supervision enables accurate setting of target tissue drug concentration

290

A new venous infusion path monitoring system utilizing electrostatic induced potential.  

Science.gov (United States)

A new venous infusion pathway monitoring system has been developed for hospital and home use. The system consists of linear and digital integrated circuits and a low-power 8-bit single chip microcomputer which constantly monitors the infusion pathway intactness. A 330 kHz AC voltage, which is induced on the patient's body by electrostatic coupling from a 330 kHz pulse oscillator, can be recorded by main and reference electrodes wrapped around the infusion polyvinyl chloride tube. If the injection needle or infusion tube becomes detached, then the system detects changes in the induced AC voltages and alerts the nursing station, via the nurse call system or PHS (personal handy phone system). PMID:19163413

Ogawa, Hidekuni; Yonezawa, Yoshiharu; Maki, Hiromichi; Caldwell, W Morton

2008-01-01

291

Acute atropine intoxication with psychiatric symptoms by herbal infusion of Pulmonaria officinalis (Lungwort  

Directory of Open Access Journals (Sweden)

Full Text Available Background and objectives: Lungwort infusion is a preparation extracted from Pulmonaria officinalis which is occasionally used as a folk remedy for the common cold. The current report aims to describe acute atropine intoxications with delirium caused by Lungwort infusion in several members of the same family. Methods: Description of three case reports. Search of literature through Medline. Results: Three generations of a same family presented acute and moderately severe atropine intoxications after drinking an infusion prepared with Pulmonaria officinalis. Conclusions: Despite the lack of scientific evidence for its clinical use, medicinal plants continue being widely used. In spite of severe adverse effects reported, the general thought is that herbal remedies are harmless. To our knowledge, this is the first report of acute atropine intoxications with psychiatric symptoms secondary to Pulmonaria officinalis in several members of a family. We suspect that the lungwort infusion may have been contaminated with some other substance with atropinic properties.

Enrique Baca-García

2007-06-01

292

Hemodynamic effects of mannitol infusion in patients with acute intracerebral hemorrhage  

Directory of Open Access Journals (Sweden)

Full Text Available PURPOSE: To evaluate hemodynamic effects of mannitol infusion in patients with acute intracerebral hemorrhage. METHODS: Thirty patients with acute intracerebral hemorrhage were enrolled. Transcranial doppler was used to detect variables of bilateral middle cerebral arteria (MCA including mean velocity (Vm and pulsitility index (PI before and after125ml and 250ml mannitol infusion (0, 30, 60, 90, 120, 180, 240 min. RESULTS: When 125ml or 250ml mannitol was infused in patients with acute intracerebral hemorrhage, Vm of bilateral MCA elevated, and reached the top at 30min, and then decreased. PI decreased in the affected MCA (250ml and in the unaffected MCA (125ml and 250ml. CONCLUSION: Mannitol infusion in patients with acute intracerebral hemorrhage can improve cerebral blood flow in bilateral hemispheres and decrease intracranial pressure in the hemorrhagic hemisphere (250ml and in the nonhemorrhagic hemisphere (125ml and 250ml.

Hong Ye

2013-02-01

293

Hemodynamic effects of mannitol infusion in patients with acute intracerebral hemorrhage  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english PURPOSE: To evaluate hemodynamic effects of mannitol infusion in patients with acute intracerebral hemorrhage. METHODS: Thirty patients with acute intracerebral hemorrhage were enrolled. Transcranial doppler was used to detect variables of bilateral middle cerebral arteria (MCA) including mean veloc [...] ity (Vm) and pulsitility index (PI) before and after125ml and 250ml mannitol infusion (0, 30, 60, 90, 120, 180, 240 min). RESULTS: When 125ml or 250ml mannitol was infused in patients with acute intracerebral hemorrhage, Vm of bilateral MCA elevated, and reached the top at 30min, and then decreased. PI decreased in the affected MCA (250ml) and in the unaffected MCA (125ml and 250ml). CONCLUSION: Mannitol infusion in patients with acute intracerebral hemorrhage can improve cerebral blood flow in bilateral hemispheres and decrease intracranial pressure in the hemorrhagic hemisphere (250ml) and in the nonhemorrhagic hemisphere (125ml and 250ml).

Hong, Ye; Yingying, Su.

2013-02-01

294

The effect of barium infusion rate on the diagnostic value of small bowel enteroclysis  

International Nuclear Information System (INIS)

Although enteroclysis may have many advantages over the conventional methods of small bowel examination, the contrast material is not always infused at a rate appropriate to gain maximum diagnostic information. In this study, 190 patients were examined by small bowell enteroclysis at five contrast infusion rates ranging from 50 to 150 ml/min using a newly designed infusion pump system. The results show that at rates above 75 ml/min, motility disturbances are masked by small bowel dilatation and paralysis, transit times are extended and morphological detail is obscured. At rates below 75 ml/min, incomplete filling of the loops renders optimal diagnostic evaluation impossible. An infusion rate of 75 ml/min was found to be optimal for initiating small bowel studies. This rate can be adjusted for individual cases when pathology or drugs affect the motility of the small bowel. 13 refs.; 5 figs.; 1 table

295

IPMC-assisted miniature disposable infusion pumps with embedded computer control  

Science.gov (United States)

For military applications, the availability of safe, disposable, and robust infusion pumps for intravenous fluid and drug delivery would provide a significant improvement in combat healthcare. To meet these needs, we have developed a miniature infusion prototype pump for safe and accurate fluid and drug delivery that is programmable, lightweight, and disposable. In this paper we present techniques regarding inter-digitated IPMCs and a scaleable IPMC that exhibits significantly improved force performance over the conventional IPMCs. The results of this project will be a low cost accurate infusion device that can be scaled from a disposable small volume liquid drug delivery patch to disposable large volume fluid resuscitation infusion pumps for trauma victims in both the government and private sectors of the health industry.

Vohnout, Sonia; Kim, Sang-Mun; Park, Il-Seok; Banister, Mark; Tiwari, Rashi; Kim, Kwang J.

2007-04-01

296

Intra-arterial Infusion of Leptin does not Affect Blood Pressure in Salt-loaded Rabbits  

Directory of Open Access Journals (Sweden)

Full Text Available The aim of this research is to see the effect of intra-arterial infusion of leptin on blood pressure of salt loaded rabbits in vivo. Increased blood pressure was produced in rabbits by giving diets containing 8% sodium chloride for 5 weeks. Leptin in different concentrations was infused intra-arterially into rabbits fed on high salt diets and the response was compared in rabbits fed with low salt diets. High salt diets produced significant increase in blood pressure. In rabbits fed with low salt diet, leptin infused intra-arterially caused an increase in blood pressure while infusion of leptin into rabbits fed with high salt diets does not affect the blood pressure. In conclusion, salt loading to rabbits abolishes the effect of leptin on cardiovascular system. This may indicate that leptin effect on sympathetic activity is altered by high salt diets in these animals.

Mohammad Nidal Khabaz

2010-01-01

297

Effects of various arterial infusion solutions on red blood cells in the newborn  

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AIM—To examine in vitro the effects of brief contact with various infusion solutions on red blood cells from newborn infants, as occurs in the "waste" syringe during routine blood sampling from umbilical artery catheters. The mixture of blood and solution in the "waste" syringe is usually reinfused into the baby. Reinfused red blood cells may be damaged by the infusion solution. It is hypothesised that an isotonic amino acid solution would cause no red blood cell agglut...

Jackson, J.; Derleth, D.

2000-01-01

298

Systemic and regional hemodynamic effects of enalaprilat infusion in experimental normotensive sepsis  

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Angiotensin-converting enzyme inhibitors have been shown to improve splanchnic perfusion in distinct shock states. We hypothesized that enalaprilat potentiates the benefits of early fluid resuscitation in severe experimental sepsis, particularly in the splanchnic region. Anesthetized and mechanically ventilated mongrel dogs received an intravenous infusion of live Escherichia coli over a period of 30 min. Thereafter, two interventions were performed: fluid infusion (normal saline, 32 mL/kg ov...

Rahal L.; Garrido A.G.; Cruz Jr. R.J.; Rocha e Silva M.; Poli-de-Figueiredo L.F.

2006-01-01

299

The infusion of fauna of water cleaning installations working with mechanical method  

International Nuclear Information System (INIS)

According to our investigations 77 kinds of infusions are determined in the watercleaning installations, working with mechanical method. In the given article the description of watercleaning installations, spreading of infusions on taxons in water purifying basins, their changes according to the seasons, the number of dynamics on biotops, the comparison of siliofauna of cleaning installations on their role in the cleaning of water are analyzed

300

Antioxidant capacity and polyphenolic content of blueberry (Vaccinium corymbosum L.) leaf infusions.  

Science.gov (United States)

Antioxidant capacity and polyphenolic content of leaf infusions prepared from six highbush blueberry cultivars (Vaccinium corymbosum L.), one wild lowbush blueberry cultivar (Vaccinium myrtillus L.), and one commercially available mix of genotypes were determined. In order to simulate household tea preparation conditions, infusions were prepared in water heated to 95 degrees C. The dynamics of extraction of polyphenolic antioxidants were monitored over the course of 30 minutes. Extraction efficiency, quantified in terms of the total phenol (TP) content, and antioxidant capacity of infusions, evaluated by the ferric reducing antioxidant power (FRAP) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radical scavenging assays, were compared with cultivar type and extraction time. The 30-minute infusions exhibited the highest TP content and antioxidant capacity according to all three assays. Wild blueberry infusion had the highest TP content (1,879 mg/L gallic acid equivalents [GAE]) and FRAP values (20,050 microM). The range of TP values for 30-minute infusions was 394-1,879 mg/L GAE with a mean of 986 mg/L GAE across cultivars; FRAP values fell between 3,015 and 20,050 microM with a mean of 11,234 microM across cultivars. All 30-minute infusions exhibited significant scavenging capacity for DPPH(*) and ABTS(*+) radicals, comparable to different concentrations of catechin, gallic acid, and 6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid. Overall, tested infusions showed significant reducing capacity as well as radical scavenging potential, which places blueberry leaf tea high on the list of dietary sources of antioxidants. PMID:19627210

Piljac-Zegarac, J; Belscak, A; Piljac, A

2009-06-01

 
 
 
 
301

Phenolic profiles of cultivated, in vitro cultured and commercial samples of Melissa officinalis L. infusions  

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Melissa officinalis L. (lemon balm) is normally consumed as infusions and presents therapeutic properties such as sedative, carminative and antispasmodic, being also included in some pharmaceutical preparations. The phenolic profiles of different samples of lemon balm prepared as infusions were evaluated by HPLC-DAD-ESI/MS. The profiles were compared in order to understand the differences between cultivated, in-vitro cultured and commercial (bags and granulated) samples. All the samples showe...

Barros, Lillian; Duen?as, Montserrat; Dias, Maria Ine?s; Sousa, Maria Joa?o; Santos-buelga, Celestino; Ferreira, Isabel C. F. R.

2013-01-01

302

Numerical modelling of a composite fuselage manufactured by liquid resin infusion  

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FUSCOMP (FUSelage COMPosite) is a Research & Development program which has received the label from the Aerospace Valley competitiveness cluster. It will lead to a test of a composite fuselage demonstrator manufactured by the Liquid Resin Infusion (LRI) process. LRI is based on the moulding of high performance composite parts by infusing liquid resin on dry fibers instead of prepreg fabrics. The study of this proof of concept is based on the TBM 850 airframe, a pressurized business turboprop a...

Perret, Adrien; Mistou, Se?bastien; Denaud, Louis Etienne; Molle?, Thierry; Veyrac, Claudia; Karama, Moussa

2011-01-01

303

The role of 5-hydroxytryptamine in the feline response to intravenous infusion of live E. coli.  

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A standardized septic shock was induced in cats by intravenous infusion of a live E. coli bacteria strain. The bacterial infusion induced a rapid haemodynamic response characterized mainly by a pulmonary arterial hypertension and a late phase characterized by systemic hypotension and hypodynamic circulation. Systemic arterial, pulmonary arterial, portal venous, left atrial pressures, max inspiratory-expiratory pressure difference in the trachea, aortic and intestinal blood flows were monitore...

Arvidsson, S.; Falk, A.; Haglind, E.; Haglund, U.

1983-01-01

304

Computed tomographic assessment of noninvasive intranasal infusions in dogs with fungal rhinitis  

International Nuclear Information System (INIS)

The distribution of infusate administered to 12 dogs with fungal rhinitis, using a noninvasive, intranasal technique, was evaluated by computed tomography (CT). In every dog, contrast medium was identified on the postinfusion CT images, within the frontal sinuses, and throughout all areas of the nasal cavity. Adverse effects were transient and mild. The results of this study indicate that intranasal infusion may be a viable alternative to trephination of the frontal sinuses to administer antifungal medications in dogs with fungal rhinitis

305

Albumin infusion in humans does not model exercise induced hypervolaemia after 24 hours  

Science.gov (United States)

We rapidly infused 234 +/- 3 mL of 5% human serum albumin in eight men while measuring haematocrit, haemoglobin concentration, plasma volume (PV), albumin concentration, total protein concentration, osmolality, sodium concentration, renin activity, aldosterone concentration, and atrial natriuretic peptide concentration to test the hypotheses that plasma volume expansion and plasma albumin content expansion will not persist for 24 h. Plasma volume and albumin content were expanded for the first 6 h after infusion (44.3 +/- 1.9-47.2 +/- 2.0 mL kg-1 and 1.9 +/- 0.1-2.1 +/- 0.1 g kg-1 at pre-infusion and 1 h, respectively, P < 0.05), but by 24 h plasma volume and albumin content decreased significantly from 1 h post-infusion and were not different from pre-infusion (44.8 +/- 1.9 mL kg-1 and 1.9 +/- 0.1 g kg-1, respectively). Plasma aldosterone concentration showed a significant effect of time over the 24 h after infusion (P < 0.05), and showed a trend to decrease at 2 h after infusion (167.6 +/- 32.5(-1) 06.2 +/- 13.4 pg mL-1, P = 0.07). These data demonstrate that a 6.8% expansion of plasma volume and 10.5% expansion of plasma albumin content by infusion does not remain in the vascular space for 24 h and suggest a redistribution occurs between the intravascular space and interstitial fluid space.

Haskell, A.; Gillen, C. M.; Mack, G. W.; Nadel, E. R.

1998-01-01

306

Sensitization to methyl methacrylate in the plastic catheter of an insulin pump infusion set  

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Cases of allergic contact dermatitis due to acrylics in the adhesive used to attach the needle to the tubing have previously been reported in pump infusion set users, but never previously due to an acrylic in the plastic tubing itself, as in this case. The presence of methyl methacrylate demonstrated in the catheter of the patient’s own infusion set correlated with her positive patch test results. Since patch testing and chemical-physical analysis was negati...

Saccabusi, Stanislao; Boatto, Gianpiero; Asproni, Battistina; Pau, Amedeo

2001-01-01

307

Infusion of nonmyeloablative bone marrow alleviates acute rejection reaction in liver allotransplantation*  

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Objective: To study the effect and implication of nonmyeloablative donor specific bone marrow (DSBM) infusion on the immunoreaction of liver allotransplantation. Methods: Orthotopic liver transplantation model was used in this study. Groups were set as follows: Group I, syngeneic control (Wistar-to-Wistar); Group II, acute rejection (SD-to-Wistar); Group III, acute rejection treated with cyclosporine A (CsA) by intramuscular injection (SD-to-Wistar+CsA); Group IV, bone marrow infusion at 7 d ...

Xie, Hai-yang; Huang, Dong-sheng; Jia, Chang-ku; Zheng, Shu-sen

2005-01-01

308

Radical resection for low rectal carcinoma combined with infusion pump chemotherapy via internal iliac artery  

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Objective To evaluate the effects and practicability of radical resection for low rectal carcinoma with infusion pump chemotherapy via internal iliac artery,and explore the correlation factors influencing the therapeutic effects.Methods Data of 316 patients with low rectal carcinoma,admitted from Oct.1997 to Mar.2008,were retrospectively analyzed and assigned into 2 groups according to the treatment: Patients received infusion pump chemotherapy via internal iliac artery to target area combine...

Yang, Bo; Pu, Yong-dong; He, Jian-miao; Liu, Bin; Dong, Li-guo; Cao, Zhi-yu; Qin, Rong; Liu, Wei-ping; Wang, Yi; Wu, You-jun; Lv, Gang

2011-01-01

309

Regional cerebral blood flow velocity changes after indomethacin infusion in preterm infants.  

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Cerebral blood flow velocity was assessed during infusion of indomethacin over 30 minutes. Eleven preterm infants with symptomatic patent ductus arteriosus were studied on 12 occasions. Indomethacin infusion was associated with a significant reduction in time averaged mean velocity (TAMV), peak systolic velocity (PSV), and end diastolic velocity in both the anterior cerebral artery and middle cerebral artery. The fall in the TAMV and PSV was gradual with maximal change 30-40 minutes after the...

Austin, N. C.; Pairaudeau, P. W.; Hames, T. K.; Hall, M. A.

1992-01-01

310

Exercise-mediated vasodilation in human obesity and metabolic syndrome: effect of acute ascorbic acid infusion.  

Science.gov (United States)

We tested the hypothesis that infusion of ascorbic acid (AA), a potent antioxidant, would alter vasodilator responses to exercise in human obesity and metabolic syndrome (MetSyn). Forearm blood flow (FBF, Doppler ultrasound) was measured in lean, obese, and MetSyn adults (n = 39, 32 ± 2 yr). A brachial artery catheter was inserted for blood pressure monitoring and local infusion of AA. FBF was measured during dynamic handgrip exercise (15% maximal effort) with and without AA infusion. To account for group differences in blood pressure and forearm size, and to assess vasodilation, forearm vascular conductance (FVC = FBF/mean arterial blood pressure/lean forearm mass) was calculated. We examined the time to achieve steady-state FVC (mean response time, MRT) and the rise in FVC from rest to steady-state exercise (?, exercise - rest) before and during acute AA infusion. The MRT (P = 0.26) and steady-state vasodilator responses to exercise (?FVC, P = 0.31) were not different between groups. Intra-arterial infusion of AA resulted in a significant increase in plasma total antioxidant capacity (174 ± 37%). AA infusion did not alter MRT or steady-state FVC in any group (P = 0.90 and P = 0.85, respectively). Interestingly, higher levels of C-reactive protein predicted longer MRT (r = 0.52, P < 0.01) and a greater reduction in MRT with AA infusion (r = -0.43, P = 0.02). We concluded that AA infusion during moderate-intensity, rhythmic forearm exercise does not alter the time course or magnitude of exercise-mediated vasodilation in groups of young lean, obese, or MetSyn adults. However, systemic inflammation may limit the MRT to exercise, which can be improved with AA. PMID:25038148

Limberg, Jacqueline K; Kellawan, J Mikhail; Harrell, John W; Johansson, Rebecca E; Eldridge, Marlowe W; Proctor, Lester T; Sebranek, Joshua J; Schrage, William G

2014-09-15

311

A continuous [15O]H2O production and infusion system for PET imaging  

International Nuclear Information System (INIS)

A system for continuous production and infusion of [15O]H2O has been designed for PET cerebral blood flow studies. The injection system consists of a four-port-two-position valve, two Horizon Nxt infusion pumps, and a sterile 50 ml vial. The variation of the production of [15O]H2O was <1%. The variation of activity delivered measured by scanner counts during the steady state period was <2%

312

Flow manipulation and control methodologies for vacuum infusion processes  

Science.gov (United States)

Vacuum Infusion Processes (VIPs) are very attractive composite manufacturing processes since large structures such as fuselages and wind blades can be fabricated in a cost effective manner. In VIPs, the fabric layers are placed on a one sided mold which is closed by enveloping the entire mold with a thin plastic film and evacuating the air out. The vacuum compresses the fabric and when a resin inlet is opened, resin flows into the mold. The resin is allowed to cure before demolding the structure. However, VIPs causes non-repeatable and problematic resin filling patterns due to the heterogeneous nature of the material, nesting between various layers, and the hand labor utilized for laying up the fabric. The design of the manufacturing process routinely involves a trial and error model which make manufacturing costs and development time difficult to estimate. The clear solution to improving the reliability and robustness of VIPs is to implement a system capable of on-line flow control. While on-line flow control has been studied and developed for other composite manufacturing processes, the VIPs have been largely ignored as there are few process parameters that lend themselves to effective flow control. In this work, two new processes were discovered with the goal of on-line control of VIPs in mind. These two processes referred to as Flow Flooding Chamber (FFC) and Vacuum Induced Preform Relaxation (VIPR) will be discussed. They both employ an external vacuum chamber to influence the permeability of the fabric temporarily which allows one to redirect the resin flow to resin starved regions of the mold. The VIPR process in addition uses a low and regulated vacuum pressure in the external chamber to increase the permeability of the fabric in a controllable manner. The objective is to understand how the VIPR process affects the resin flow in order to implement it into a complete flow control and automated environment which will reduce or eliminate the variability experienced. First, the effect on permeability is characterized, so the process can be simulated and the flow front patterns can be predicted. It was found that using the VIPR process in combination with tool side injection gates is a very effective method to control resin flow. Based on this understanding several control algorithms were developed to use the process in an automated manufacturing environment which were tested and validated in a virtual environment. To implement and demonstrate the approach, an experimental workstation was built and various infusion examples were performed in the automated environment to validate the capability of the VIPR process with the control methodologies. The VIPR process with control consistently performed better than the process without control. This contribution should prove useful in making VIPs more reliable in the production of large scale composite structures.

Alms, Justin B.

313

CT angiography by means of intra-arterial contrast infusion  

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CT angiography (CT-AG) by means of intra-arterial contrast infusion was carried out, and its clinical usefulness was evaluated in various intracranial lesions. The practical and diagnostic merits of CT-AG are as follows: a selective enhancement of the cerebral vessels by an extremely small amount of the contrast substance, accompanied by a satisfactory resolution of fine arterioles and arteries. The excellent ability of the CT to detect differences in the X-ray absorption coefficients surpasses that of cerebral angiography. An intracranial aneurysm which was not visualized by the angiography appeared between arterial branches upon CT-AG. The three-dimensional configuration of the aneurysmal body and its related artery, the pointing direction of the aneurysm, and the angle between the aneurysmal axis and the afferent artery were clearly shown. The fine structure of arteriovenous malformation could be shown concurrently with the cerebral tissue and the ventricle. The axial view of the circle of Willis gives important information for surgical intervention. Concerning brain tumors, the structural correlation between the tumor and the cerebral arteries became apparent when the CT-AG was carried out immediately after a conventional contrast-enhancement. Such a ''double contrast'' allows safe surgical access to the intracranial tumor. CT-AG in the case of ''Moyamoya'' disease visualized fine moyamoya vessels extending all over the cerebral hemisphere; those vessels were less prominent in the ordinary angiograms. The vascular networks of the arteriovenous malformation, which were not evident in the ordinary angiograms, were also revealed by the CT-AG. For the patient with poor prospects, CT-AG will be were valid as a screening study than ordinary angiography because of its less invasive procedure using a small amount of the contrast substance. CT-AG on a dynamic scan mode possible optimal timing in the visualization of the arteriovenous malformation.

Okada, Junichiro; Watanabe, Hiroshi; Shiogai, Toshiyuki; Konishi, Yoshifumi; Hara, Mitsuhiro (Kyorin Univ., Mitaka, Tokyo (Japan). School of Medicine)

1983-10-01

314

CT angiography by means of intra-arterial contrast infusion  

International Nuclear Information System (INIS)

CT angiography (CT-AG) by means of intra-arterial contrast infusion was carried out, and its clinical usefulness was evaluated in various intracranial lesions. The practical and diagnostic merits of CT-AG are as follows: a selective enhancement of the cerebral vessels by an extremely small amount of the contrast substance, accompanied by a satisfactory resolution of fine arterioles and arteries. The excellent ability of the CT to detect differences in the X-ray absorption coefficients surpasses that of cerebral angiography. An intracranial aneurysm which was not visualized by the angiography appeared between arterial branches upon CT-AG. The three-dimensional configuration of the aneurysmal body and its related artery, the pointing direction of the aneurysm, and the angle between the aneurysmal axis and the afferent artery were clearly shown. The fine structure of arteriovenous malformation could be shown concurrently with the cerebral tissue and the ventricle. The axial view of the circle of Willis gives important information for surgical intervention. Concerning brain tumors, the structural correlation between the tumor and the cerebral arteries became apparent when the CT-AG was carried out immediately after a conventional contrast-enhancement. Such a ''double contrast'' allows safe surgical access to the intracranial tumor. CT-AG in the case of ''Moyamoya'' disease visualized fine moyamoya vessels extending all over the cerebral hemisphere; those vessels were less prominent in the ordinary angiograms. The vascular networks of the arteriovenous malformation, which were not evident in the ordinary angiograms, were also revealed by the CT-AG. For the patient with poor prospects, CT-AG will be were valid as a screening study than ordinary angiography because of its less invasive procedure using a small amount of the contrast substance. CT-AG on a dynamic scan mode possible optimal timing in the visualization of the arteriovenous malformation. (J.P.N.)

315

saline-infused sonohysterography: tips for achieving greater success.  

Science.gov (United States)

Saline-infused sonohysterography (SIS) may help improve visualization of the endometrium and endometrial cavity and assess tubal patency. Although most SIS procedures are straightforward, a variety of pitfalls may lead to an unsuccessful procedure or incomplete evaluation. SIS should be scheduled between days 4 and 10 of the patient's menstrual cycle, when the endometrium is at its thinnest, and physiologic changes during the secretory phase are not present. Performing preprocedure imaging serves many purposes, such as depicting hydrosalpinx, causes of uterine and adnexal tenderness, and pelvic inflammatory disease, as well as assessing the size and position of the uterus and the orientation of the cervix. It is important not to presume that fibroids are the cause of bleeding when the endometrium is obscured at preprocedure imaging. Obstacles to a successful procedure include issues related to patient anxiety and discomfort, which may be prevented or minimized at almost every step of the procedure. Inability to obtain access to the cervix is the most common cause of unsuccessful SIS; proper patient positioning in a semi-upright lithotomy position is important. Injection of air during any US-guided procedure may lead to shadowing that obscures the region of interest. Adequate distention of the endometrial cavity is crucial for successful SIS, and optimal positioning of the distended balloon may improve the degree of distention. However, poor distention may be indicative of an underlying pathologic condition. Knowledge of these pitfalls and the strategies to overcome them may prevent premature or unnecessary termination of an otherwise successful study. PMID:22084183

Allison, Sandra J; Horrow, Mindy M; Kim, Han Y; Lev-Toaff, Anna S

2011-01-01

316

The efficacy of intraperitoneal saline infusion for percutaneous radiofrequency ablation for hepatocellular carcinoma  

Energy Technology Data Exchange (ETDEWEB)

Objective: To evaluated the efficacy and safety of radiofrequency ablation (RFA) with intraperitoneal saline infusion. Background: Ultrasound-guided RFA is not always feasible due to the tumor location, possible adjacent tissue damage or poor sonographic identification. Patients and methods: Ultrasound-guided RFA with intraperitoneal saline infusion was performed in 116 patients between June 2001 and March 2008. Results: The overall technical feasibility of the intraperitoneal saline infusions was 90.5% (105 patients). The purposes of the intraperitoneal saline infusion were achieved in 100 patients (86.2%) by visualizing the tumor located in hepatic dome (47 patients), prevent adjacent organ damage (42 patients) and withdrawing overlying omentum (10 patients). Complete ablation of tumor was accomplished in 102 patients (87.9%). Complications associated with the treatment occurred in seven patients (6.0%). There was no case of adverse event directly related to intraperitoneal saline infusion. Conclusions: Intraperitoneal saline infusion is an effective and safe procedure that can be used to overcome the current limitations of ultrasound-guided RFA.

Park, Soo Young [Department of Internal Medicine, Liver Research Institute, Graduate School of Medicine, Kyungpook National University, Daegu (Korea, Republic of); Tak, Won Young, E-mail: wytak@knu.ac.k [Department of Internal Medicine, Liver Research Institute, Graduate School of Medicine, Kyungpook National University, Daegu (Korea, Republic of); Jeon, Seong Woo; Cho, Chang Min; Kweon, Young Oh; Kim, Sung Kook; Choi, Yong Hwan [Department of Internal Medicine, Liver Research Institute, Graduate School of Medicine, Kyungpook National University, Daegu (Korea, Republic of)

2010-06-15

317

Experimental intraperitoneal infusion of OK-432 in rats: Evaluation of peritoneal complications and pathology  

Energy Technology Data Exchange (ETDEWEB)

Purpose: OK-432 is known to be a potent sclerosant of cystic lesions. The purpose of this study was to evaluate both its safety and pathologic effects after the infusion of OK-432 into the peritoneal cavity of rats. Materials and methods: Twenty male rats were used in this study. Twelve rats were infused intraperitoneally with 0.2 Klinishe Einheit of OK-432 melted in 2 mL of normal saline (group 1: the treated group); four rats each were infused intraperitoneally with 0.5 mL of 99% ethanol (group 2) and normal saline (group 3), and served as the control groups. An abdominal ultrasonographic examination was performed both before and after the infusions in all rats. Three rats in group 1 and one rat in each of groups 2 and 3 were sacrificed each week following the infusion. Gross and microscopic evaluations of the peritoneum and abdominal cavity were performed on each rat. Results: In group 1, the abdomen was clear on gross inspection and the peritoneum was unremarkable on microscopic examination. In group 2, mild-to-moderate peritoneal adhesions were revealed grossly, and inflammation and fibrosis of the peritoneum were demonstrated microscopically. In group 3, no specific abnormalities were noted on gross or microscopic examinations. Conclusion: Leakage or abnormal infusion of OK-432 solution into the peritoneal cavity during sclerotherapy of intra-abdominal or retroperitoneal cystic lesions does not result in any significant complications.

Kim, Dong Wook [Department of Radiology, Busan Paik Hospital, Inje University College of Medicine, Busan (Korea, Republic of); Kim, Hak Jin, E-mail: hakjink@pusan.ac.k [Department of Radiology, Pusan National University Hospital, Pusan National University College of Medicine, Medical Research Institute, Busan (Korea, Republic of); Lee, Jun Woo [Department of Radiology, Pusan National University Hospital, Pusan National University College of Medicine, Medical Research Institute, Busan (Korea, Republic of)

2010-06-15

318

Determination of lead, cadmium and arsenic in infusion tea cultivated in north of Iran.  

Science.gov (United States)

Tea is one of the most common drinks in all over the world. Rapid urbanization and industrialization in recent decades has increased heavy metals in tea and other foods. In this research, heavy metal contents such as lead (Pb), cadmium (Cd) and arsenic (As) were determined in 105 black tea samples cultivated in Guilan and Mazandaran Provinces in north of Iran and their tea infusions. The amount of heavy metals in black tea infusions were analyzed using Inductively Coupled Plasma Atomic Emission Spectroscopy (ICP - AES).The mean?±?SD level of Pb in 5, 15 and 60 min in infusion tea samples were 0.802?±?0.633, 0.993?±?0.667 and 1.367?±?1.06 mg/kg of tea dry weight, respectively. The mean level of Cd in 5, 15 and 60 min in infusion tea samples were 0.135?±?0.274, 0.244?±?0.46 and 0.343?±?0.473 mg/kg of tea dry weight, respectively. The mean level of As in 5, 15 and 60 min in infusion tea samples were 0.277?±?0.272, 0.426?±?0.402 and 0.563?±?0.454 mg/kg of tea dry weight, respectively. Also, the results showed that the locations and the infusion times influenced upon the amount of these metals (P?

Shekoohiyan, Sakine; Ghoochani, Mahboobeh; Mohagheghian, Azita; Mahvi, Amir Hossein; Yunesian, Masoud; Nazmara, Shahrokh

2012-01-01

319

Intra-arterial and intraportal infusion liver scintigraphy using 99mTc-labeled colloid  

International Nuclear Information System (INIS)

Intra-arterial infusion liver scintigraphy was performed in 11 patients with primary or metastatic liver tumor. and intraportal infusion liver scintigraphy was performed in 6 patients for prophylaxis of liver metastasis from colorectal cancer. 99mTc-Sn colloid or 99mTc-phytate was administered through the catheter of which tip was placed in the portal vein or the hepatic artery, and then liver image was obtained. When 99mTc-phytate was infused intra-arterially, significant amount of the infused tracer passed through the liver and we could not get sufficient information to assess the distribution of drug administered through the catheter. On the other hand, intraportal infusion liver scintigraphy using 99mTc-Sn colloid or 99mTc-phytate and intra-arterial infusion liver scintigraphy using 99mTc-Sn colloid revealed heterogenity of liver uptake, tracer uptake in spleen, low uptake area corresponding to the liver tumor and high uptake area around it. The findings will be clinically useful, and these methods are thought to be helpful to confirm the satisfactory drug distribution. (author)

320

Eggplant (Solanum melongena infusion has a modest and transitory effect on hypercholesterolemic subjects  

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Full Text Available Eggplant (Solanum melongena is consumed extensively in Brazil. It has been believed that infusion of a powdered preparation of the fruit may reduce serum cholesterol. However, there are few documented reports on its effects on cholesterol metabolism and its possible hypocholesterolemic effect has not been proved by well-controlled studies. The aim of the present study was to observe the effects of S. melongena on the serum cholesterol and triglycerides of 38 hypercholesterolemic human volunteers ingesting S. melongena infusion for five weeks. Thirty-eight hypercholesterolemic subjects receiving either S. melongena infusion (N = 19 or placebo (N = 19 participated in two clinical experiments in which the effect of S. melongena infusion was studied with (N = 16 or without (N = 38 dietary orientation. Total cholesterol and its fractions, triglycerides, and apolipoproteins A and B were measured in blood at the beginning of the experiment and three and five weeks thereafter. No differences were observed compared to control. Intraindividual analysis showed that S. melongena infusion significantly reduced the blood levels of total and LDL cholesterol and of apolipoprotein B. After dietary orientation, no intra- or intergroup differences were seen for any of the parameters analyzed. The results suggest that S. melongena infusion had a modest and transitory effect, which was not different from that obtained with standard orientation for dyslipidemia patients (diet and physical activities.

Guimarães P.R.

2000-01-01

 
 
 
 
321

Oviposition activity of Aedes aegypti L. (Diptera: Culicidae) in response to different organic infusions.  

Science.gov (United States)

The present study investigates new sources of infusion as an oviposition attractant for Aedes aegypti L. Infusions with fetid and non-fetid odors were compared as an oviposition stimulant. Traps baited with infusions of dehydrated cashew leaves (Anacardium occidentale), potato peels (Solanum tuberosum) and graminea (Panicum maximum) were compared as attractants, and the effect of odor (fetid and unfetid) on attractiveness was tested. Oviposition activity changed significantly according to the concentration and type of infusion (F = 4.1279; gl = 2; P = 0.0231). A larger number of eggs were observed in cups containing 50% A. occidentale (non-fetid odor) and 30% P. maximum (fetid odor). When compared in the same cage, comparable oviposition was found between A. occidentale and P. maximum. Moreover, approximately 20% more eggs were recorded in the infusion without odor when compared to the grass infusion and water. These findings suggest A. occidentale as a new stimulant for use in ovitraps for Aedes surveillance and control, with the benefit of having an agreeable odor. PMID:20498970

Santos, Eloína; Correia, Juliana; Muniz, Luciana; Meiado, Marcos; Albuquerque, Cleide

2010-01-01

322

Oviposition activity of Aedes aegypti L. (Diptera: Culicidae) in responseto different organic infusions  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english The present study investigates new sources of infusion as an oviposition attractant for Aedes aegypti L. Infusions with fetid and non-fetid odors were compared as an oviposition stimulant. Traps baited with infusions of dehydrated cashew leaves (Anacardium occidentale), potato peels (Solanum tuberos [...] um) and graminea (Panicum maximum) were compared as attractants, and the effect of odor (fetid and unfetid) on attractiveness was tested. Oviposition activity changed significantly according to the concentration and type of infusion (F = 4.1279; gl = 2; P = 0.0231). A larger number of eggs were observed in cups containing 50% A. occidentale (non-fetid odor) and 30% P. maximum (fetid odor). When compared in the same cage, comparable oviposition was found between A. occidentale and P. maximum. Moreover, approximately 20% more eggs were recorded in the infusion without odor when compared to the grass infusion and water. These findings suggest A. occidentale as a new stimulant for use in ovitraps for Aedes surveillance and control, with the benefit of having an agreeable odor.

Eloína, Santos; Juliana, Correia; Luciana, Muniz; Marcos, Meiado; Cleide, Albuquerque.

2010-04-01

323

Eggplant (Solanum melongena) infusion has a modest and transitory effect on hypercholesterolemic subjects  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english Eggplant (Solanum melongena) is consumed extensively in Brazil. It has been believed that infusion of a powdered preparation of the fruit may reduce serum cholesterol. However, there are few documented reports on its effects on cholesterol metabolism and its possible hypocholesterolemic effect has n [...] ot been proved by well-controlled studies. The aim of the present study was to observe the effects of S. melongena on the serum cholesterol and triglycerides of 38 hypercholesterolemic human volunteers ingesting S. melongena infusion for five weeks. Thirty-eight hypercholesterolemic subjects receiving either S. melongena infusion (N = 19) or placebo (N = 19) participated in two clinical experiments in which the effect of S. melongena infusion was studied with (N = 16) or without (N = 38) dietary orientation. Total cholesterol and its fractions, triglycerides, and apolipoproteins A and B were measured in blood at the beginning of the experiment and three and five weeks thereafter. No differences were observed compared to control. Intraindividual analysis showed that S. melongena infusion significantly reduced the blood levels of total and LDL cholesterol and of apolipoprotein B. After dietary orientation, no intra- or intergroup differences were seen for any of the parameters analyzed. The results suggest that S. melongena infusion had a modest and transitory effect, which was not different from that obtained with standard orientation for dyslipidemia patients (diet and physical activities).

P.R., Guimarães; A.M.P., Galvão; C.M., Batista; G.S., Azevedo; R.D., Oliveira; R.P., Lamounier; N., Freire; A.M.D., Barros; E., Sakurai; J.P., Oliveira; E.C., Vieira; J.I., Alvarez-Leite.

1027-10-01

324

Effects of erythrocyte infusion on VO2max at high altitude  

DEFF Research Database (Denmark)

This study investigated whether autologous erythrocyte infusion would ameliorate the decrement in maximal O2 uptake (VO2max) experienced by lowlanders when they ascend to high altitude. VO2max was measured in 16 men (treadmill running) at sea level (SL) and on the 1st (HA1) and 9th (HA9) days of high-altitude (4,300 m) residence. After VO2max was measured at SL, subjects were divided into two matched groups (n = 8). Twenty-four hours before ascent to high altitude, the experimental group received a 700-ml infusion of autologous erythrocytes and saline (42% hematocrit), whereas the control group received only saline. The VO2max of erythrocyte-infused [54 +/- 1 (SE) ml.kg-1.min-1] and control subjects (52 +/- 2 ml.kg-1.min-1) did not differ at SL before infusion. The decrement in VO2max on HA1 did not differ between groups, averaging 26% overall, despite higher (P <0.01) arterial hematocrit, hemoglobin concentration, and arterial O2 content in the erythrocyte-infused subjects. By HA9, there were no longer any differences in hematocrit, hemoglobin concentration, or arterial O2 content between groups. No change in VO2max occurred between HA1 and HA9 for either group. Thus, despite increasing arterial O2-carrying capacity, autologous erythrocyte infusion did not ameliorate the decrement in VO2max at 4,300-m altitude.

Young, Jette Feveile; Sawka, M N

1996-01-01

325

Depressed left ventricular performance. Response to volume infusion in patients with sepsis and septic shock  

International Nuclear Information System (INIS)

Volume infusion, to increase preload and to enhance ventricular performance, is accepted as initial management of septic shock. Recent evidence has demonstrated depressed myocardial function in human septic shock. We analyzed left ventricular performance during volume infusion using serial data from simultaneously obtained pulmonary artery catheter hemodynamic measurements and radionuclide cineangiography. Critically ill control subjects (n = 14), patients with sepsis but without shock (n = 21), and patients with septic shock (n = 21) had prevolume infusion hemodynamic measurements determined and received statistically similar volumes of fluid resulting in similar increases in pulmonary capillary wedge pressure. There was a strong trend (p = 0.004) toward less of a change in left ventricular stroke work index (LVSWI) after volume infusion in patients with sepsis and septic shock compared with control subjects. The LVSWI response after volume infusion was significantly less in patients with septic shock when compared with critically ill control subjects (p less than 0.05). These data demonstrate significantly altered ventricular performance, as measured by LVSWI, in response to volume infusion in patients with septic shock

326

[Distribution and interaction of bone marrow mesenchymal stem cells and cord blood CIK/NK cells infused via different ways at different time periods in NOD/SCID mice].  

Science.gov (United States)

The study was aimed to explore the distribution and interaction mechanism of human bone marrow mesenchymal stem cells (MSC) and cord blood cytokine-induced killer (CIK)/natural killer (NK) cells infused via different ways at different times in NOD/SCID mice. 5 microl 1, 1'-dioctadecyl-3, 3, 3', 3'-tetramethylindocarbocyanine perchlorate (DiI) dye(red) was added in suspension of MSC per ml, and 1 microl carboxyfluorescein diacetate, succinimidyl ester(CFDA SE) dye(green) was added in suspension of CIK/NK cells per ml. The amounts of MSC and CIK/NK cells infused in each 6 NOD/SCID mouse were 1 x 10(6) (0.1 ml) and 1 x 10(7) (0.1 ml) respectively. All mice were divided into 4 groups, each group consisted of 6 mice. Group A: MSC (intravenous infusion, iv) + CIK/NK cells (iv) at the same time, group B: MSC (iv) + CIK/NK cells (iv) at 48 hours after infusion of MSC; group C: MSC (intramedullary infusion, im) + CIK/NK cells (iv) at the same time; group D: MSC (im) + CIK/NK cells (iv) at 48 hours after infusion of MSC. 3 NOD/SCID mice were sacrificed per batch at 24 hours and 48 hours after infused CIK/NK cells. Frozen sections of liver, spleen, lung and kidney were prepared, and then followed by counting the amounts of red and green fluorescence cells under fluorescence microscope, and calculating the ratio of MSC to CIK/NK cells for reflecting the interaction of MSC and CIK/NK cells in mice, and for showing the suppressive intensity of MSCs on CIK/NK cells. The results showed that the sums of average ratios of MSC to CIK/NK cells in lung, liver and spleen of group A and B were higher than that in group C and D at 24 hours and 48 hours respectively after infusing CIK/NK cells. The sum of average ratios of MSC to CIK/NK cells in group A was slightly higher than that in group B at 24 hours and 48 hours after infusing CIK/NK cells, but there was no significant difference between them. The sum of average ratios of MSC to CIK/NK cells in lung, liver and spleen in group C was slightly lower than that in group D at 24 hours after infusing CIK/NK cells, but reversed at 48 hours later and there was no significant difference between them. The sums of average ratios of MSC to CIK/NK cells in lung, liver and spleen in group A, B, C and D were all higher than those in kidney at 24 and 48 hours respectively after infusing CIK/NK cells. It is concluded, the MSC and CIK/NK cells may interact if they are infused via the same way and at the same time, the location where the suppression of MSC on CIK/NK cells occur in vivo may be reticulo-endothelial systems in lungs and livers. PMID:20137135

Li, Yang; Wang, Xiao-Ping; Guo, Hai-Xia; Huang, Ke; Wei, Jing; Zhou, Dun-Hua; Huang, Wen-Ge; Wu, Yan-Feng; Huang, Shao-Liang

2010-02-01

327

Prolonged infusion of angiotensin II in apoE(-/-) mice promotes macrophage recruitment with continued expansion of abdominal aortic aneurysm.  

Science.gov (United States)

Angiotensin II (AngII) infusion initiates abdominal aortic aneurysm (AAA) development due to medial disruption and results in luminal dilation and thrombus formation. The objective of this study was to determine whether AAA progressed during protracted AngII infusion. Male apoE(-/-) mice were infused with AngII using miniosmotic pumps. On day 27, suprarenal aortic luminal diameters were ultrasonically measured to identify mice exhibiting AAAs. Mice were designated to three groups with similar mean luminal dilation. Group 1 mice were sacrificed on day 28. Group 2 and 3 mice were subsequently infused with saline or AngII, respectively, for an additional 56 days. In Group 2, saline infusion-after the initial 28 days of AngII infusion-led to an immediate decrease in systolic blood pressure. Over the subsequent 56 days of saline infusion, there were no aneurysm-related deaths or significant changes in luminal diameter. In contrast, continuous AngII infusion in Group 3 maintained persistently increased systolic blood pressure, with aneurysmal rupture-associated deaths, increased luminal diameters, and tissue remodeling. Aortic aneurysmal segments that expanded during continuous AngII infusion exhibited macrophage accumulation in regions of medial disruption, predominantly on the adventitial aspect. Macrophages immunostained for CD206 more than for iNOS, consistent with an M2 phenotype. In conclusion, prolonged AngII infusion promotes AAA expansion, and is associated with enhanced rupture rates and increased macrophage infiltration. PMID:21763672

Rateri, Debra L; Howatt, Deborah A; Moorleghen, Jessica J; Charnigo, Richard; Cassis, Lisa A; Daugherty, Alan

2011-09-01

328

Consumption of Ocimum sanctum L. and Citrus paradisi infusions modulates lipid metabolism and insulin resistance in obese rats.  

Science.gov (United States)

A high saturated fat and fructose diet leads to metabolic disorders through dysregulation of genes involved in lipid metabolism. Consumption of plant infusions reduces these obesity alterations, but the precise mechanism remains unclear. In this study, we investigated the effect and the possible mechanism of Ocimum sanctum L. (OS) and Citrus paradisi (CP) infusions in diet-induced obese rats. CP and OS infusions suppressed hepatic tissue fat accumulation, and significantly down-regulated the mRNA levels of two hepatic lipogenesis genes: sterol regulatory element binding protein 1c (SREBP1c) and fatty acid synthase (FAS) compared with the obese control. Treatment with these infusions up-regulated the hepatic expression of mRNA related to mitochondrial fatty acid uptake: peroxisome proliferator activated receptor alpha (PPAR?) and the expression of carnitine palmitoyl-transferase 1a (CPT1a). Both infusions improved insulin resistance, with OS showing the major effect. Consumption of these infusions reduces the damage caused by free radicals, protecting hepatic lipids and proteins. Additionally, plant infusions increase activity of hepatic enzymes: glutathione S-transferase (GST), glutathione peroxidase (GPX), and catalase (CAT). Our results suggest that the effects of CP and OS infusions on lipid metabolism are related to the down-regulation of genes involved in lipogenesis, particularly for OS, and to the increase in lipid ?-oxidation, especially for CP infusion. In conclusion, the consumption of these plant infusions is a feasible adjuvant therapy for metabolic changes induced by obesity. PMID:24584283

Gamboa-Gómez, Claudia; Salgado, Luis M; González-Gallardo, Adriana; Ramos-Gómez, Minerva; Loarca-Piña, Guadalupe; Reynoso-Camacho, Rosalía

2014-05-01

329

Pharmacokinetics and analgesic effect of ropivacaine during continuous epidural infusion for postoperative pain relief.  

DEFF Research Database (Denmark)

BACKGROUND: The pharmacokinetics and clinical efficacy of ropivacaine (2.5 mg/ml) during a 24-h continuous epidural infusion for postoperative pain relief in 20 patients scheduled for abdominal hysterectomy were characterized using an open-label, increasing-dose design. METHODS: Through an epidural catheter inserted at T10-T12, a test dose of 7.5 mg ropivacaine was given 3 min before a bolus dose of 42.5 mg and immediately followed by a 24-h continuous epidural infusion with either 10 or 20 mg/h. Peripheral venous plasma samples were collected up to 48 h after infusion, and urinary excretion was followed up to the end of infusion. Postoperative pain at rest, on coughing, and at mobilization was assessed by means of a visual analog scale 2,4,6,8,12, and 24 h after the end of surgery. Sensory (pinprick) and motor block (modified Bromage scale) were assessed at the same intervals. RESULTS: The total plasma concentrations of ropivacaine increased markedly and consistently during the 24-h epidural infusion, in contrast to stable unbound concentrations. Both total and unbound plasma concentrations at the end of infusion were proportional to the total dose, although only the latter was proportional to the infusion rate. The total and unbound plasma clearance was independent of dose. Total mean clearance decreased on average by 21% (P < 0.001) during the last 12 h of epidural infusion, i.e., from 539 +/- 191 ml/min to 418 +/- 138 ml/min, indicating time-dependent kinetics. The unbound clearance also varied between estimates after 8 h of infusion and the end of treatment, i.e., a 5.3% decrease from 10.4 +/- 5.3 l/min to 9.5 +/- 3.9 l/min (P < 0.05). The unbound fraction of ropivacaine in plasma decreased during treatment, and this was related to the increase in alpha1-acid glycoprotein concentration. Pain was generally well controlled, and median visual analog scale scores during mobilization were less than 30 mm in patients receiving ropivacaine at 20 mg/h. CONCLUSIONS: The pharmacokinetics of ropivacaine were independent of dose, but total clearance decreased with time over 24 h. The consistent increase in total plasma concentration during the postoperative epidural infusion contrasted to much less variation in the unbound plasma concentrations of ropivacaine.

Erichsen, C J; Sjövall, J

1996-01-01

330

Intragastric infusion of denatonium conditions flavor aversions and delays gastric emptying in rodents.  

Science.gov (United States)

Because most naturally occurring toxins taste bitter to humans, any mechanism that reduces the rate at which bitter substances are ingested and digested should be adaptive. Based on the recent discovery of T2R bitter taste receptors in the gastrointestinal tract of rodents, we asked whether intragastric (IG) infusion of denatonium (a ligand for T2R receptors) would condition a flavor aversion and/or delay gastric emptying. Four experiments tested for post-oral responses to denatonium in rodents. First, Sprague-Dawley rats were trained to associate intake of a flavored solution (the CS+) with IG denatonium infusions, and intake of a different-flavored solution (the CS-) with IG water infusions during 30 min/day sessions. The rats acquired an aversion to the CS+ flavor when it was paired with IG infusions of 10 mM (but not 2.5 mM) denatonium. Intragastric infusions of 10 mM denatonium also delayed gastric emptying of food in the same rats. Second, we asked how long it took for rats to suppress their drinking while being infused IG with 10 mM denatonium. Rats drinking a palatable solution paired with IG infusions of 10 mM denatonium suppressed their licking within 6 min, as compared to rats infused IG with water. Third, we trained C57BL/6J (B6) mice 24 h/day to associate a CS+ flavor paired with IG infusions of 12 mM denatonium (diluted to 6 mM by orally consumed CS+). Like rats, the mice acquired a robust aversion to the CS+ flavor when it was paired with IG infusions of denatonium. A final experiment assessed the potential toxicity of denatonium. To this end, we gave B6 mice a 6 mM denatonium solution as their only source of water for 3 weeks. The mice grew normally and did not display any clinical signs of denatonium toxicosis. This study provides the first evidence that rodents respond to the presence of "bitter" substances in their gastrointestinal tract by generating both behavioral and physiological responses. PMID:18174110

Glendinning, John I; Yiin, Yeh-Min; Ackroff, Karen; Sclafani, Anthony

2008-03-18

331

Cisatracurium infusion for neuromuscular blockade in the pediatric intensive care unit: A dose-finding study.  

Science.gov (United States)

OBJECTIVE: To evaluate the safety and efficacy of cisatracurium besylate, a neuromuscular blocking agent in infants zero to 2 yrs of age. DESIGN: An open-label study to evaluate efficacy and safety of cisatracurium as a continuous infusion in infants. SETTING: A tertiary pediatric intensive care unit. PATIENTS: Eleven children, 0-2 yrs of age, requiring prolonged neuromuscular blockade. INTERVENTIONS: Cisatracurium besylate, 0.1 mg/kg, was administered as an intravenous bolus dose and repeated if necessary until a >90% neuromuscular blockade, as determined by train-of-four response, was achieved. Patients were allowed to recover to 90% blockade (I/IV twitch) after the initial bolus and were administered continuous infusion at 2 &mgr;g/kg/min. The continuous infusion rate was adjusted to maintain a train-of-four response of 0-I/IV, with an increase in the rate preceded by a bolus dose of cisatracurium besylate. An electromyographic monitor was used to measure recovery at the end of infusion, when possible. Heart rate and blood pressure were recorded after the initial bolus dose and after changes in infusion rates. Blood samples were drawn at steady-state during cisatracurium infusion at several different times during the study and at the end of infusion for measurement of plasma cisatracurium and laudanosine concentrations. MEASUREMENTS AND MAIN RESULTS: The mean infusion rate of cisatracurium besylate required to maintain train-of-four response of 0-I/iv was 5.4 +/- 3.0 &mgr;g/kg/min. The mean total duration of infusion was 64.5 +/- 36 hrs. Ten percent and complete neuromuscular recovery occurred at 26.6 +/- 10.4 and 74.8 +/- 32 mins, respectively, after discontinuation of infusion. Mean cisatracurium and laudanosine concentrations were 342.5 +/- 169 and 163.3 +/- 116 ng/mL, respectively. Four (37%) patients had undetectable (<5 ng/mL) cisatracurium concentrations at the time of 100% neuromuscular recovery (train-of-four response of IV/IV or no fade at 50 mA on the electromyogram). No significant hemodynamic changes were observed during treatment with cisatracurium besylate (p <.05). CONCLUSIONS: A longer period of recovery from neuromuscular blockade was observed compared with reports of older children. Recovery from neuromuscular blockade after long-term use was not associated with any adverse events in the immediate postinfusion period. Cisatracurium besylate is a safe and effective neuromuscular blocking agent for children 0-2 yrs of age. PMID:12780965

Odetola, Folafoluwa O.; Bhatt-Mehta, Varsha; Zahraa, Jihad; Moler, Frank W.; Custer, Joseph R.

2002-07-01

332

[A comparison of a tramadol/metamizole infusion with the combination tramadol infusion plus ibuprofen suppositories for postoperative pain management following hysterectomy].  

Science.gov (United States)

Postoperative pain management is still a grossly neglected field. In most cases, antipyretic analgesics alone are insufficient during the early postoperative period. Powerful narcotics are often avoided or underdosed because they are associated with the risk of respiratory depression. Some authors recommend combined infusion of tramadol and metamizole, which is assumed to provide sufficient pain relief without the risk of respiratory depression. However, this regimen has not yet been investigated in a study that meets currently accepted scientific standards. METHODS. Sixty patients who underwent vaginal hysterectomy were included in a randomised, prospective double-blind study. Thirty women received two placebo suppositories immediately after induction of anaesthesia and a postoperative infusion of tramadol and metamizole (400 mg tramadol plus 5 g [= 10 ml] metamizole in 500 ml electrolyte solution). The 30 women of the control group received two ibuprofen suppositories (585.2 mg) preoperatively and a post-operative tramadol infusion (400 mg tramadol plus 10 ml placebo [NaCl 0.9%] in 500 mg electrolyte solution). The patients of both groups received 125 ml of the appropriate infusion solution as a loading dose over 10 min (corresponding to 1.25 mg metamizole and 100 mg tramadol in the metamizole/tramadol group or 100 mg tramadol in the ibuprofen/tramadol group) 10 min after awakening. The remaining solution was administered at an infusion rate of 12.5-25 ml/h (corresponding to 125-250 mg metamizole and 10-20 mg tramadol/h or 10-20 mg tramadol/h). On request or when complaining of stronger pain, the patients received an additional bolus infusion of 125 ml over 10 min. In case of insufficient pain reduction despite repeated infusion of 125-ml boli or consumption of the entire infusion solution, the patients discontinued the study and received demand-adapted intravenous titration of piritramide. Postoperative pain was evaluated on the visual analogue scale (VAS) and the 101-point numerical rating scale immediately before the start of the infusion. Pain evaluation was repeated 20, 30, 40, 60, 100, 120, and 240 min after awakening accompanied by registration of heart rate, respiratory rate, systolic and diastolic blood pressure, and side effects. RESULTS. About 60% of the entire infusion solution was administered within 60 min in both groups. Significant postoperative pain reduction in both groups and on both the 101-point scale and the VAS was observed only at 100, 120, and 240 min after awakening. In the tramadol/metamizole group, nausea occurred in 7 cases and vomiting in 1. Nine patients in this group additionally required intravenous piritramide because of insufficient pain relief. In the tramadol/ibuprofen group, 8 patients complained about nausea and 4 patients vomited. Six patients additionally received intravenous piritramide because of insufficient pain reduction. CONCLUSIONS. Satisfactory pain reduction occurred rather late despite high doses of both the tramadol/metamizole and the tramadol/ibuprofen. Both analgesic combination must be regarded as insufficient after inhalational anaesthesia because of the very slow onset of action and the high failure rate. PMID:1636921

Striebel, H W; Hackenberger, J

1992-06-01

333

Complications of continuous intraperitoneal insulin infusion with an implantable pump  

Science.gov (United States)

AIM: To monitor the course of continuous intraperitoneal insulin infusion (CIPII) and to gain more insight into possible complications. METHODS: A retrospective, longitudinal observational cohort study in patients with type 1 diabetes mellitus (T1DM) was performed. Only patients with “brittle” T1DM who started CIPII between January 1, 2000 and June 1, 2011, and were treated in the only centre in The Netherlands providing CIPII treatment (Isala clinics, Zwolle) were eligible for inclusion. Outcomes were defined as operation-free period (OFP), rate and type of complications. Subanalyses were made between patients starting CIPII from 2000 to 2007 and from 2007 onwards in order to study possible changes over time in complications and/or OFP. The OFP was calculated as the time from initial implantation to the date of first documented re-operation. If patients had not experienced an operation, their data were recorded at the date of last follow up or death. Kaplan-Meier curves were constructed to visualize the OFP. A (two-sided) P value of less than 0.05 was considered statistically significant. RESULTS: Fifty-seven patients were treated with CIPII, although one patient was excluded from analyses because of self-induced complications. In the remaining 56 patients, 70 complications occurred during 283 patient years. Catheter occlusion (32.9%), pump dysfunction (17.1%), pain at the pump site (15.7%) and infections (10.0%) were the most frequent complications. This resulted in a median OFP of 4.5 years (95% confidence interval 4.1-4.8 years) without any difference between the time periods. Fifty re-operations were performed because of complications, one per 5.6 patient years, with a decrease in pump dysfunction (P = 0.04) and pump explantations (P = 0.02) after 2007. In total, 9 episodes of ketoacidosis occurred during follow up and there were 69 hospital re-admissions, with a median duration of 6 d. CIPII was ceased in five patients due to recurrent infections (n = 2), pain (n = 1), inadequate glycaemic control (n = 1) or by own choice (n = 1). No CIPII related mortality was reported. CONCLUSION: The OFP has been stable over the last decade. No CIPII related mortality was reported. A significant decrease in pump dysfunction and explantation was seen after 2007 compared to the period 2000-2007. CIPII remains a safe treatment modality for specific patient groups. PMID:22912916

van Dijk, Peter R; Logtenberg, Susan JJ; Groenier, Klaas H; Haveman, Jan Willem; Kleefstra, Nanno; Bilo, Henk JG

2012-01-01

334

Propofol lipidic infusion promotes resistance to antifungals by reducing drug input into the fungal cell  

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Full Text Available Abstract Background The administration of non-antifungal drugs during patient hospitalization might be responsible for discrepancies between in vitro and in vivo susceptibility to antifungals. Propofol is often administered to intensive care units as a sedative. The purpose of this study was to evaluate the effect of propofol lipidic infusion upon the growth and susceptibility profile of pathogenic fungi. Candida and Aspergillus were studied regarding the ability to grow and its susceptibility profile to antifungals in the presence of propofol infusion (Fresenius® (1.25, 2.5 and 5 mg.ml-1 and its lipidic vehicle. The intensity of fluorescence after staining with FUN1, in the presence and absence of propofol infusion, was determined by flow cytometry. Radioactivity assays were also performed in order to quantify the input of [3H]- itraconazole into the fungal cell in the presence of propofol. Assays were repeated after addition of sodium azide, in order to block efflux pumps. Results Propofol infusion promoted budding of Candida and the germination of Aspergillus, latter forming a lipid layer around the hypha. An increase of minimal fungicidal concentrations regarding both Candida and Aspergillus strains was found for all antifungals when incubated simultaneously with propofol infusion. A decrease of the intensity of fluorescence of Candida cells was systematically observed, as well as a significant reduced intracellular uptake of [3H] itraconazole in cells treated with propofol infusion, even after the blockade of efflux pumps. The results obtained when testing with the lipid vehicle were similar. Conclusion Propofol infusion, due to its lipidic vehicle, increased the fungal germination and promoted resistance to antifungals. This effect seems to be related to the reduced access and/or permeabilization to fungal cells by antifungals.

Pina-Vaz Cidália

2008-01-01

335

Effect of intra-arterial infusion with triolein emulsion on rabbit liver  

Science.gov (United States)

AIM: To determine whether intra-arterial infusion of triolein emulsion has biochemical and histopathologic effect on rabbit liver. METHODS: An emulsion of 0.2 mL triolein in 20 mL of saline was infused into either the hepatic arteries of nine rabbits (group 1) or the superior mesenteric arteries of 12 rabbits (group 2). Five rabbits infused with 20 mL of normal saline were used as a control group (group 3). The serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were measured to evaluate liver function in each group just before the infusion, at 2 h, day 1, day 4, and day 7 following infusion. Each rabbit in all of the groups was infused with Evans blue on day 7 to evaluate changes in vascular permeability, and obtain the stained area of the hepatic surface. If the stained area was not available, the anteroinferior portion of the right hepatic lobe was selected. The obtained tissues were examined by light, electron and confocal microscopy. The changes in AST and ALT levels at each time point were calculated and statistically analyzed using a mixed linear model. A P value 0.05). Only three rabbits in each group showed hepatic surface staining with the Evans blue dye. Light and electron microscopic findings showed no specific changes in the selected hepatic tissues. Confocal microscopic examination with transferase-mediated dUTP nick-end labeling stain revealed lack of hepatocyte apoptosis in any of the groups. There were no differences in the results between group 1 and group 2. CONCLUSION: Infusion of triolein emulsion into rabbit livers revealed a minimal transient decrease of liver function, and no specific histopathologic changes.

Kim, Yong-Woo; Park, Young Mi; Yoon, Sik; Kim, Hak Jin; Park, Do Yoon; Cho, Byung Mann; Choi, Seon Hee

2014-01-01

336

Iatrogenic neonatal and maternal hyponatraemia following oxytocin and aqueous glucose infusion during labour.  

Science.gov (United States)

Maternal and umbilical cord serum sodium and osmolality were studied prospectively in 140 deliveries to investigate whether transplacental hyponatraemia, seen following oxytocin infusion during labour, was due to the antidiuretic effect of oxytocin or was secondary to the infusion of aqueous glucose used as a vehicle for oxytocin, or both. Forty-five women received oxytocin in aqueous glucose for induction or augmentation of labour (oxytocin group), 43 received aqueous glucose infusion alone (glucose group) and 52 did not receive any intravenous infusions (control group). Mean cord sodium levels were significantly lower in the oxytocin (131.4, SD 3.6 mmol/l) and glucose groups (132.5, SD 3.2 mmol/l) than in the control group (135.0, SD 3.0 mmol/l). Hyponatraemia (Na less than 130 mmol) was seen in 47% and 30% of the infants in the oxytocin and glucose groups respectively, in contrast to only 5.8% of the infants in the control group. Significant negative linear correlations were seen between serum sodium and the dose of oxytocin (P less than 0.01) and log of the volume of glucose solution infused (P less than 0.001). The hyponatraemic newborn infants had a significantly higher incidence of transient neonatal tachypnea (7/37, 19%) than the normonatraemic infants (2%). Our results strongly suggest that infusion of oxytocin and glucose both cause maternal and transplacental hyponatraemia, even in recommended doses. This should be taken in account while planning a safe dose of oxytocin and glucose for infusion during labour. PMID:3986166

Singhi, S; Chookang, E; Hall, J S; Kalghatgi, S

1985-04-01

337

Body Temperatures During Exercise in Deconditioned Dogs: Effect of NACL and Glucose Infusion  

Science.gov (United States)

Infusion of glucose (Glu) into normal exercising dogs attenuates the rise in rectal temperature (Delta-Tre) when compared with delta-Tre during FFA infusion or no infusion. Rates of rise and delta-=Tre levels are higher during exercise after confinement. Therefore, the purpose of this study was to determine if Glu infusion would attenuate the exercise-induced excess hyperthermia after deconditioning. Rectal and quadricep femoris muscle temperatures (Tmu) were measured in 7 male, mongrel dogs dogs (19.6 +/- SD 3.0 kg) during 90 minutes of treadmill exercise (3.1 +/-SD 0.2 W/kg) with infusion (30ml/min/kg) of 40% Glu or 0.9% NaCL before BC) and after confinement (AC) in cages (40 x 110 x 80 cm) for 8 wk. Mean (+/-SE body wt. were 19.6 +/- 1.1 kg BC and 19.5 +/- 1.1kg AC, exercise VO2 were not different (40.0 - 42.0 mi/min/kg-1). With NaCl AC, NaCl BC, GluAC, and GluBC: Delta-Tre were, 1.8, 1.4, 1.3 and 0.9C respectively; and Delta-Tmu were 2.3, 1.9, 1.6, and 1.4C. respectively (P<0.05 from GluBC). Compared with NaCl infusion, attenuated both Delta-Tre and Delta-Tmu BC and AC, respectively. Compared with GluBC, GluAC attenuated Delta-Tmu but not Delta-Tre. Thus. with similar heat production, the mechanism for attenuation at bad body temperature with Glu infusion must affect avenues of heat dissipation.

Greenleaf, J. E.; Kruk, B.; Nazar, K.; Kaciuba-Usciko, H.

2000-01-01

338

Body temperature, behavior, and plasma cortisol changes induced by chronic infusion of Staphylococcus aureus in goats.  

Science.gov (United States)

Most experimentally induced fevers are acute, usually lasting approximately 6-12 h, and thus do not mimic chronic natural fevers, which can extend over several days or more. To produce a model of chronic natural fever, we infused eight goats (Capra hircus) intravenously with 2 ml of 2 x 10(11) cell walls of Staphylococcus aureus (S. aureus) for 6 days using osmotic infusion pumps (10 microl/h) while measuring changes in body temperature, behavior, and plasma cortisol concentration. Seven control animals were infused with sterile saline. Abdominal temperature-sensitive data loggers and osmotic infusion pumps were implanted under halothane anesthesia. To compare our new model with existing models of experimental fever, we also administered 2-ml bolus intravenous injections of 2 x 10(11) S. aureus cell walls, 0.1 microg/kg lipopolysaccharide (Escherichia coli, serotype 0111:B4), and sterile saline in random order to six other goats. Bolus injection of lipopolysaccharide and S. aureus induced typical acute phase responses, characterized by fevers lasting approximately 6 h, sickness behavior, and increased plasma cortisol concentration. Infusion of S. aureus evoked prolonged fevers, which lasted for approximately 3 days, starting on day 4 of infusion (ANOVA, P cortisol concentration to rise (ANOVA, P > 0.05) or the expression of sickness behavior. In conclusion, infusion of S. aureus produced a fever response resembling that of sustained natural fevers but did not elicit the cortisol and behavioral responses that often are described clinically and during short-term experimental fevers. PMID:15217786

Mphahlele, Noko R; Fuller, Andrea; Roth, Joachim; Kamerman, Peter R

2004-10-01

339

C-Section  

Medline Plus

Full Text Available C-Section Introduction A Cesarean section, or C-section, is the surgical delivery of a baby through ... the baby while recovering from surgery. After a C-Section The hospital stay after a C-section ...

340

C-Section  

Medline Plus

Full Text Available C-Section Introduction A Cesarean section, or C-section, is the surgical delivery of a baby through an ... the baby while recovering from surgery. After a C-Section The hospital stay after a C-section is ...

 
 
 
 
341

Use of technetium-99m hexamethylpropylene amine oxime SPET for the study of cerebral blood flow reactivity after acetazolamide infusion in patients with Behcet's disease  

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The purpose of this study was to characterise the nature of the baseline perfusion defects found in patients with Behcet's disease using hexamethylpropylene amine oxime single-photon emission tomography in conjunction with acetazolamide test (Acz SPET). Eleven patients underwent both baseline and Acz SPET. Regions of interest (ROIs) were drawn on the areas with decreased perfusion (D-ROI) and, in the same section, on areas with normal perfusion (N-ROI). The ROIs were then repositioned on the corresponding section on Acz SPET. The mean ROI counts were then transformed into a perfusion index value (PIV) with reference to the global brain counts. In total we found 24 D-ROIs (17 in the cortical and 7 in subcortical grey matter). The influence of Acz infusion was selectively registered in the D-ROIs, where PIVs changed from 1.23{+-}0.17 (baseline SPET) to 1.63{+-}0.23 (Acz SPET) (P<0.001). No significant difference was seen in the N-ROIs (1.46{+-}0.21 and 1.40{+-}0.17, respectively, on baseline SPET and Acz SPET). Our results demonstrate that Acz infusion increases the regional cerebral blood flow within baseline grey matter perfusion defects. This finding suggests that baseline perfusion abnormalities could reflect a disconnection rather than local vasculitic involvement. (orig.)

Pupi, A.; Sestini, S.; Cristofaro, M.T.R. de; Meldolesi, U. [Department of Clinical Physiopathology, Nuclear Medicine Section, Careggi Hospital, University of Florence, Florence (Italy); Emmi, L.; Marchione, T.; Salvati, G.; Li Gobbi, F. [Department of Clinical Immuno-allergology, Careggi Hospital, University of Florence, Florence (Italy); Massacesi, L. [Departments of Neurological and Psychiatrical Science, Careggi Hospital, University of Florence, Florence (Italy)

2000-06-01

342

Use of technetium-99m hexamethylpropylene amine oxime SPET for the study of cerebral blood flow reactivity after acetazolamide infusion in patients with Behcet's disease  

International Nuclear Information System (INIS)

The purpose of this study was to characterise the nature of the baseline perfusion defects found in patients with Behcet's disease using hexamethylpropylene amine oxime single-photon emission tomography in conjunction with acetazolamide test (Acz SPET). Eleven patients underwent both baseline and Acz SPET. Regions of interest (ROIs) were drawn on the areas with decreased perfusion (D-ROI) and, in the same section, on areas with normal perfusion (N-ROI). The ROIs were then repositioned on the corresponding section on Acz SPET. The mean ROI counts were then transformed into a perfusion index value (PIV) with reference to the global brain counts. In total we found 24 D-ROIs (17 in the cortical and 7 in subcortical grey matter). The influence of Acz infusion was selectively registered in the D-ROIs, where PIVs changed from 1.23±0.17 (baseline SPET) to 1.63±0.23 (Acz SPET) (P<0.001). No significant difference was seen in the N-ROIs (1.46±0.21 and 1.40±0.17, respectively, on baseline SPET and Acz SPET). Our results demonstrate that Acz infusion increases the regional cerebral blood flow within baseline grey matter perfusion defects. This finding suggests that baseline perfusion abnormalities could reflect a disconnection rather than local vasculitic involvement. (orig.)

343

Duration and distribution of experimental muscular hyperalgesia in humans following combined infusions of serotonin and bradykinin  

DEFF Research Database (Denmark)

The present study examined distribution and duration of muscle hyperalgesia to pressure stimuli after intramuscular bolus-infusions of serotonin (5-HT, 20 nmol) and bradykinin (BKN, 10 nmol) in 10 volunteers. Infusions were given into the tibialis anterior (TA) muscle over 20 s with an inter-infusions interval of 3 min. Infusions of isotonic saline (NaCl, 0.9%) were given as control. Pain intensity was continuously scored on a visual analogue scale (VAS), and subjects drew the distribution of the pain areas on an anatomical map. Pressure pain thresholds (PPTs) were assessed with an electronic algometer at the injection site (10 cm below the patella), 2, 5, and 10 cm distal from the injection site, and at the ankle. Control assessments of PPTs were done at the contralateral TA and ankle. Skin sensibility was assessed with a Von Frey hair at the same sites. All measurements were done before and 5, 20, 40, and 60 min after infusions. The VAS-peak after BKN was significantly higher (P<0.05) compared with 5-HT andthe second infusion of NaCl. The duration of the increase in VAS after 5-HT+BKN was significantly longer (P<0.05) compared with the infusions of NaCl. The local pain area after infusion of BKN was significantly larger (P<0.05) compared with 5-HT and control infusions. Cutaneous sensibility to tactile stimuli was not affected by any of the combinations. PPTs at the injection site and 2 cm (5, 20, and 40 min) were significantly decreased (P<0.05) after 5-HT+BKN compared with baseline and isotonic saline. In addition, PPTs were significantly decreased (P<0.05) after 5-HT+BKN at 5 cm (5 and 20 min) and 10 cm (5 min). Serotonin may enhance the effect of bradykinin in producing experimental muscle pain and muscle hyperalgesia to mechanical stimuli. The combination of serotonin and bradykinin can produce muscle hyperalgesia, lasted for up to 40 min and located within the muscle. No widespread hyperalgesia to the ankle and other leg (tested at 10 cm below the patella and ankle) was observed suggesting a predominant peripheral origin of the experimentally induced hyperalgesic stage.

Babenko, Victor; Svensson, Peter

2000-01-01

344

Development and in vitro evaluation of a flow-adjustable elastic drug infusion pump.  

Science.gov (United States)

Passive-type drug infusion pumps have several advantages over active-type pumps including a simple drug chamber structure and relatively high operational stability. However, conventional passive-type infusion pumps also have several limitations compared to active ejection pumps, such as a fixed flowrate and monotonic flow pattern. To enhance the clinical feasibility of using passive-type drug infusion pumps, flow readjustment and flow regulation abilities are needed. This paper proposes a new portable elastic drug infusion pump that integrates the advantages of active and passive infusion pumps to improve clinical feasibility. The proposed infusion pump incorporates a passively driven drug chamber and an actively adjusted flow controller, which can adjust and regulate various target flowrates and adjust the flow pattern in accordance with the patient's time-varying physiological status. The proposed infusion pump uses the contraction force of an expanded elastic membrane to extract the drug from the drug chamber for delivery into the patient's body through an outlet catheter. It also utilizes a flow sensor, a flow resistor, and a motor-driven flow restrictor that can monitor the real-time flowrate through the outlet catheter and automatically regulate the actual flow-rate around the target value. Experiments on the proposed system resulted in actual injection rates of 0.49 +/- 0.03 (mean +/- standard deviation), 0.98 +/- 0.03, 1.49 +/- 0.04, and 1.99 +/- 0.03 ml/h when the target injection rate was set to 0.5, 1.0, 1.5, and 2.0 ml/h, respectively. During the entire period of operation from the fully filled state to the totally empty state, an inner-chamber pressure of >100 mmHg was maintained, which shows that the proposed infusion pump can stably maintain its target flowrate as the amount of drug remaining to be injected decreases. It appears that the proposed drug infusion pump can be applied to a wide variety of patient treatments that require short-term, accurate, and stable drug delivery. PMID:22292205

Choi, S W; Kang, S M; Kim, H Y; Nam, K W

2011-11-01

345

The flavonoids casticin and artemetin are poorly extracted and are unstable in an Artemisia annua tea infusion  

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A number of flavonoids including casticin and artemetin from Artemisia annua have shown synergism with artemisinin against Plasmodium falciparum, but it is unclear if flavonoids are also extracted into a tea infusion of the plant. Using a tea infusion preparation protocol that was reported to be highly effective for artemisinin extraction, we measured casticin and artemetin extraction. There was only a 1.8% recovery of casticin in the infusion while artemetin was undetectable. After 24 hr sto...

Weathers, Pj; Towler, Mj

2012-01-01

346

Radiosensitization By Gemcitabine Fixed-Dose-Rate Infusion Versus Bolus Injection in a Pancreatic Cancer Model1  

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It has recently been shown that fixed-dose-rate (gemcitabine) infusion may be superior to bolus gemcitabine in the treatment of metastatic pancreas cancer. We wished to compare the radiosensitizing effects of fixed-dose-rate gemcitabine infusion to standard bolus injection. We measured weight loss and mouse intestinal crypt survival to determine equally toxic concentrations of gemcitabine administered through a 3-hour fixed-dose-rate infusion versus bolus injection in combination with fractio...

Morgan, Meredith; El Shaikh, Mohamed A.; Abu-isa, Eyad; Davis, Mary A.; Lawrence, Theodore S.

2008-01-01

347

Prolonged Infusion of Angiotensin II in apoE?/? Mice Promotes Macrophage Recruitment with Continued Expansion of Abdominal Aortic Aneurysm  

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Angiotensin II (AngII) infusion initiates abdominal aortic aneurysm (AAA) development due to medial disruption and results in luminal dilation and thrombus formation. The objective of this study was to determine whether AAA progressed during protracted AngII infusion. Male apoE?/? mice were infused with AngII using miniosmotic pumps. On day 27, suprarenal aortic luminal diameters were ultrasonically measured to identify mice exhibiting AAAs. Mice were designated to three groups with simil...

Rateri, Debra L.; Howatt, Deborah A.; Moorleghen, Jessica J.; Charnigo, Richard; Cassis, Lisa A.; Daugherty, Alan

2011-01-01

348

Assessment of cerebrospinal fluid system dynamics : novel infusion protocol, mathematical modelling and parameter estimation for hydrocephalus investigations  

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Patients with idiopathic normal pressure hydrocephalus (INPH) have a disturbance in the cerebrospinal fluid (CSF) system. The treatment is neurosurgical – a shunt is placed in the CSF system. The infusion test is used to assess CSF system dynamics and to aid in the selection of patients that will benefit from shunt surgery. The infusion test can be divided into three parts: a mathematical model, an infusion protocol and a parameter estimation method. A non-linear differential equation is us...

Andersson, Kennet

2011-01-01

349

Trioctanoin infusion increases in vivo leucine oxidation: a lesson in isotope modeling  

International Nuclear Information System (INIS)

We have reported that infusion of trioctanoin in conscious dogs had little effect on leucine oxidation but decreased the rate of appearance (Ra) and interconversion of leucine and its alpha-keto acid, alpha-ketoisocaproate (KIC). To verify that these conclusions were independent of the leucine tracers and isotope models employed, the studies were repeated using [1-14C]leucine and [4,5-3H]KIC rather than [1-14C]KIC and [4,5-3H]leucine. In the present study, leucine oxidation calculated using the plasma [14C]leucine or [14C]KIC specific activities (SA) increased nearly twofold (P less than 0.001) during trioctanoin infusion in direct contrast to our previous results. When the data from either study were analyzed using the plasma SA of the leucine moiety reciprocal to the infused tracer as a potential indicator of the intracellular leucine SA, similar conclusions were obtained from either study: trioctanoin infusion in conscious dogs appears to increase whole-body leucine oxidation and does not decrease proteolysis. These studies challenge the validity of previously used isotope models of leucine metabolism and suggest that the plasma KIC SA during infusion of labeled leucine may most accurately reflect changes in whole-body leucine metabolism

350

Recycling of an amino acid label with prolonged isotope infusion: Implications for kinetic studies  

International Nuclear Information System (INIS)

To investigate whether recycling of a labeled amino acid would occur after 24 h of infusion, two groups of normal volunteers were infused with [3H]leucine and alpha-[14C]-ketoisocaproate for 4 h and [2H3]leucine for either 4 or 24 h (groups I and II, respectively). Entry of [2H3]leucine at steady state into the plasma space was indistinguishable from its infusion rate for group I but 30% higher (P less than 0.001) than this rate for group II, demonstrating significant recycling of label. After discontinuation of the infusions, isotope disappearance from the plasma space was followed for 2 h. The 3H and 14C decay data for both groups suggest that plasma leucine and alpha- ketoisocaproate are derived from a single intracellular pool in the postabsorptive state. In group I, the 3H and 2H labels decayed identically; whereas, in group II, the decay of [2H3]-leucine and alpha- [2H3]ketoisocaproate was slower (P less than 0.01) than the decay of [3H]leucine and alpha-[3H]ketoisocaproate, confirming re-entry of label after a 24-h infusion. Therefore kinetic values calculated from models assuming no recycling of labeled amino acids are most likely not quantitative and must be interpreted with care when flux does not change or decreases

351

Effects of Intrarenal and Intravenous Infusion of the Phosphodiesterase 3 Inhibitor Milrinone on Renin Secretion  

Science.gov (United States)

We have reported that administration of the phosphodiesterase III inhibitor milrinone increases renin secretion in conscious rabbits. The aim of the present study was to determine if the increase in renin secretion results from a direct renal action of milrinone, or from an indirect extrarenal effect of the drug. This was accomplished by comparing the effects of intrarenal and intravenous infusion of graded doses of milrinone on plasma renin activity in unilaterally nephrectomized conscious rabbits. Milrinone was infused into the renal artery in doses of 0.01, 0.1 and 1.0 micro-g/kg/min, and intravenously in the same rabbits in doses of 0.01, 0.1, 1.0 and 10 micro-g/kg/min. Each dose was infused for 15 min. No intrarenal dose of milrinone altered plasma renin activity or arterial pressure, although at the highest dose, there was a small increase in heart rate. Intravenous infusion of milrinone at 1.0 micro-g/kg/min increased plasma renin activity to 176 +/- 55% of the control value (P less than 0.05). Heart rate increased but arterial pressure did not change. Intravenous infusion of milrinone at 1O micro-g/kg/min increased plasma renin activity to 386 +/- 193% of control in association with a decrease in arterial pressure and an increase in heart rate. These results confirm that milrinone increases renin secretion, and indicate that the stimulation is due to an extrarenal effect of the drug.

Kumagai, Kazuhiro; Reid, Ian A.

1994-01-01

352

[The postoperative analgesic effects of magnesium infusion on brachial plexus block].  

Science.gov (United States)

Magnesium sulphate infusion decreases analgesic requirements after general anesthesia. Aim of this study was to assess the effects of postoperative magnesium infusion for 24 hours on duration of the block, sedation and postoperative analgesic consumption after brachial plexus block. After obtaining approval from local ethic committee, 70 ASA class I and II patients were included to the randomised double blind study. Brachial plexus block was performed using axillary approach with lignocaine 1.25% adrenaline 1/200 000 40 ml. Groups received 5 mg/kg bolus and 500 mg/h magnesium sulphate infusion or saline controls at the same volume during 24 hour. Analgesia and sedation were assessed while determining time to first pain and rescue analgesic, time to regain motor capability, visual analogue scale and sedation scores for every 4 hour during postoperative 24 h. period. While time to first pain and rescue analgesic was increased, total analgesic consumption was reduced significantly on magnesium infusion group (Meperidine: C: 36.3 +/- 42.6 mg, Mg: 11.7 +/- 12.2 mg, p: 0.001). Visual analogue scales were also observed to be lower in all periods. Time to motor block resolution, and sedation scores were similar. Magnesium sulphate infusion is thought as a safe and suitable adjunct for reducing analgesic consumption and possible complications without interfering daily activity in patients undergoing brachial plexus block. PMID:18095196

Anbarci, Ozlem; Apan, Alparslan; Sahin, Saziye

2007-07-01

353

Backflow length predictions during flow-controlled infusions using a nonlinear biphasic finite element model.  

Science.gov (United States)

A previously proposed finite element model that considers geometric and material nonlinearities and the free boundary problems that occur at the catheter tip and in the annular zone around the lateral surface of the catheter was revised and was used to fit a power-law formula to predict backflow length during infusions into brain tissue. Compared to a closed-form solution based on linear elasticity, the power-law formula for compliant materials predicted a substantial lower influence of the shear modulus and catheter radius on the backflow length, whereas the corresponding influence for stiffer materials was more consistent with the closed-form solution. The finite element model predicted decreases of the backflow length for reduction of the shear modulus for highly compliant materials (shear modulus less than 500 Pa) due to the increased area of infusion and the high fluid fraction near the infusion cavity that greatly increased the surface area available for fluid transfer and reduced the hydraulic resistance toward the tissue. These results show the importance of taking into account the material and geometrical nonlinearities that arise near the infusion surface as well as the change of hydraulic conductivity with strain for a proper characterization of backflow length during flow-controlled infusions into the brain. PMID:25154980

Orozco, Gustavo A; Smith, Joshua H; García, José J

2014-10-01

354

Chronic intrastriatal dopamine infusions in rats with unilateral lesions of the substantia nigra  

International Nuclear Information System (INIS)

This study examined the effects of continuously supplied dopamine delivered directly into the dopamine-deficient striatum. Rats received unilateral lesions of the substantia nigra by stereotaxic administration of 6-hydroxydopamine and were tested for apomorphine-induced rotational behavior and general activity. Osmotic mini-pumps were filled with dopamine in various concentrations, implanted subcutaneously and connected to a cannula implanted directly into the striatum. The system delivered solution at a rate of .5 ?l/hr for two weeks. Dopamine in a dosage of 0.5 ?g/per hour reduced apomorphine-induced rotational behavior by a mean of 52 +/- 5.8% (mean +/- SEM n=20) with a maximal individual decrease of 99%. There was no change in general activity or increase in stereotype behavior. Infusions of vehicle solutions did not decrease rotational behavior. Spread of the infused dopamine and its metabolites was estimated by adding 3H-dopamine to the pumps in tracer quantities. Radioactivity was highly concentrated at the infusion site and decreased rapidly within a few mm from the infusion site. Continuous infusion methods may eventually prove to be effective in the treatment of nigro-striatal degenerative disease. 12 references, 4 figures

355

Direct vs. indirect pathway of hepatic glycogen synthesis as a function of glucose infusion rate  

International Nuclear Information System (INIS)

This study was initiated to determine the influence of the rate of exogenous glucose administration on liver glycogen synthesis by the direct (glucose uptake and incorporation into glycogen) vs the indirect pathway (glucose degradation to 3-carbon intermediates, e.g., lactate, prior to incorporation into glycogen). Catheterized rats were fasted 2 days prior to receiving a 3 hr infusion of glucose at rates of 0 to 230 ?mol/min/kg containing tracer [6-3H]- and [U-14C]-glucose. Plasma glucose (r = 0.80), insulin (r = 0.90) and lactate (r = 0.84) were correlated with glucose infusion rate. The rate of liver glycogen deposition (0.46 +/- 0.03 ?mol/min/g) did not differ between a glucose infusion rate of 20 and 230 ?mol/min/kg. At the lowest and highest glucose infusion rates hepatic glycogenesis accounted for 87 +/- 6 and 9 +/- 1% of the total glucose load, respectively. The percent contribution of the direct pathways to glycogen deposition ([3H] specific activity in hepatic glycogen/[3H] specific activity in plasma glucose) increased from 16 +/- 3 to 83 +/- 5% from lowest to highest glucose infusion rates (prevailing plasma glucose concentrations: 9 +/- 1 and 21 +/- 2 mM, respectively). The results indicate that the relative contribution of the direct and indirect pathways of glucogen synthesis are dependent upon the glucose load or plasma glucose concentration

356

Antioxidant Activity of Oak (Quercus Leaves Infusions against Free Radicals and their Cardioprotective Potential  

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Full Text Available The aim of present study was to evaluate antioxidant capacity and cardioprotective potential of leaves infusions and partially purified fractions of Quercus sideroxyla and Q. eduardii (red oaks and Q. resinosa (white oak. Consumption of polyphenol-rich beverages derived from plants, such as oak may represent a beneficial diet in terms of cardiovascular protection. Infusions from Oak leaves were obtained and probed for total phenolics by Folin-Ciocalteu, DPPH and hydroxyl radicals scavenging by DPPH test and Deoxy-D-ribose method, the antioxidant capacity was evaluated by FRAP and ORAC tests, inhibitions of Low Density Lipoproteins (LDL oxidation and Angiotensin Converting Enzyme (ACE activity were measured. A HPLC analysis was performed by HPLC-MS. Bioactive polyphenols such as gallic and ellagic acids, catechin, quercetin and derivatives: naringenin and naringin were detected in Quercus infusions. A distinctive HPLC profile was observed among the red and white oak samples. Q. resinosa infusions have exhibited the highest antioxidant activity in comparison with the other species, although in the inhibition of LDL oxidation no differences were observed. In the inhibition of the ACE, Q. resinosa was more effective (IC50, 18 ppm than Q. sideroxyla, showing same effect as the control Captopril. From the results it is possible to postulate that not only chelating activity is important in these infusions, especially in Q. resinosa.

Rong (Tsao Cao

2010-01-01

357

Reassessment of primed constant-infusion tracer method to measure urea kinetics  

International Nuclear Information System (INIS)

The validity of the primed constant-infusion tracer technique to make short-term measurements of urea production rates (R/sub a/) in humans in a physiological steady state and during disruption of steady state was evaluated. Four subjects received a primed constant infusion (P/I = 560 min) of [13C]urea for 8 h. A plateau in urea enrichment was reached after 2 h and maintained throughout. When [13C]- and [18O]urea were simultaneously infused into four subjects at P/I ratios of 560:1 and 360:1, respectively, both tracers reached plateau enrichment at the same time (2-4 h). The enrichment at plateau was a function of the infusion rate rather than the priming dose, and calculated urea R/sub a/ was the same with either prime. In five additional experiments the technique responded acutely to a physiological perturbation (alanine infusion) in a dose-dependent manner. The results confirm that this technique is appropriate for short-term measurements of urea R/sub a/, and the requirement for accuracy in estimating the priming dose is not impractically stringent

358

Voxelized model of interstitial transport in the rat spinal cord following direct infusion into white matter.  

Science.gov (United States)

Direct tissue infusion, e.g., convection-enhanced delivery (CED), is a promising local delivery technique for treating diseases of the central nervous system. Predictive models of spatial drug distribution during and following direct tissue infusion are necessary for treatment optimization and planning of surgery. In this study, a 3D interstitial transport modeling approach in which tissue properties and anatomical boundaries are assigned on a voxel-by-voxel basis using tissue alignment data from diffusion tensor imaging (DTI) is presented. The modeling approach is semi-automatic and utilizes porous media transport theory to estimate interstitial transport in isotropic and anisotropic tissue regions. Rat spinal cord studies compared predicted distributions of albumin tracer (for varying DTI resolution) following infusion into the dorsal horn with tracer distributions measured by Wood et al. in a previous study. Tissue distribution volumes compared favorably for small infusion volumes (<4 microl). The presented DTI-based methodology provides a rapid means of estimating interstitial flows and tracer distributions following CED into the spinal cord. Quantification of these transport fields provides an important step toward development of drug-specific transport models of infusion. PMID:19640132

Kim, Jung Hwan; Astary, Garrett W; Chen, Xiaoming; Mareci, Thomas H; Sarntinoranont, Malisa

2009-07-01

359

Chronic intrastriatal dopamine infusions in rats with unilateral lesions of the substantia nigra  

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This study examined the effects of continuously supplied dopamine delivered directly into the dopamine-deficient striatum. Rats received unilateral lesions of the substantia nigra by stereotaxic administration of 6-hydroxydopamine and were tested for apomorphine-induced rotational behavior and general activity. Osmotic mini-pumps were filled with dopamine in various concentrations, implanted subcutaneously and connected to a cannula implanted directly into the striatum. The system delivered solution at a rate of .5 ..mu..l/hr for two weeks. Dopamine in a dosage of 0.5 ..mu..g/per hour reduced apomorphine-induced rotational behavior by a mean of 52 +/- 5.8% (mean +/- SEM n=20) with a maximal individual decrease of 99%. There was no change in general activity or increase in stereotype behavior. Infusions of vehicle solutions did not decrease rotational behavior. Spread of the infused dopamine and its metabolites was estimated by adding /sup 3/H-dopamine to the pumps in tracer quantities. Radioactivity was highly concentrated at the infusion site and decreased rapidly within a few mm from the infusion site. Continuous infusion methods may eventually prove to be effective in the treatment of nigro-striatal degenerative disease. 12 references, 4 figures.

Hargraves, R.; Freed, W.J.

1987-03-09

360

Safety of adenosine stress myocardial perfusion imaging by a one-route infusion protocol  

International Nuclear Information System (INIS)

When adenosine stress testing is performed, a vein is generally accessed in each arm. To determine whether the one-route infusion protocol, that is, infusion via one upper arm vein, is safe, myocardial perfusion imaging was performed during adenosine stress testing in patients with angina pectoris. Sixty-six consecutive patients (43 men, 68±11 years of age) with suspected coronary artery disease were enrolled in this study. For the stress test, adenosine was injected at 120 ?g/kg/min for 6 minutes. Systolic blood pressure, diastolic blood pressure, and heart rate did not show any significant changes after injection of the adenosine and radioisotope (RI) tracer. Adverse events during infusion of the adenosine were seen in 42 (64%) patients and included chest discomfort/oppression in 17 (26%) and dyspnea/throat discomfort in 15 (23%). On the other hand, adverse events just after infusion of the RI tracer occurred in 5 (8%) patients and included chest oppression in 2 (3%) and dyspnea in 1 (2%). Almost all adverse events disappeared quickly without treatment. Therefore, we concluded that adenosine stress myocardial perfusion imaging using a one-route infusion protocol is safe and useful to do for patients unable to secure veins in both arms. (author)

 
 
 
 
361

Flavor preferences conditioned in C57BL/6 mice by intragastric carbohydrate self-infusion.  

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This study determined the feasibility of conditioning flavor preferences in mice by self-administered intragastric (IG) nutrient infusions. Male C57BL/6J mice were surgically fitted with an IG catheter that was attached by a tether system to an infusion pump. The mice were given ad-libitum access to chow and a flavored solution 23 h/day. Drinking was monitored with a computerized lickometer system that controlled the infusion pumps. In Experiment 1, drinking one flavored solution (CS+, e.g., grape-saccharin) was paired with matched infusions of 8% maltodextrin, whereas drinking another solution (CS-, e.g., cherry-saccharin) was matched with water infusions across 6 one-bottle training days. During training, the mice drank more CS+ than CS-; this was due to an increase in bout size but not bout frequency. In subsequent two-bottle choice tests, the mice strongly preferred (91%) the CS+ to the CS-. Experiment 2 obtained a significant but less robust (71%) CS+ preference in mice trained with unsweetened CS solutions. These data indicate that mice, like rats, acquire an increased acceptance and preference for flavors paired with the postingestive actions of nutrients. Our understanding of flavor-nutrient learning can be advanced by studying this process in selected mouse strains and genetically modified animals. PMID:12954423

Sclafani, Anthony; Glendinning, John I

2003-09-01

362

Regional haemodynamic effect of vasopressin infusion in conscious, unrestrained, Brattleboro rats.  

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1. Incremental rates of infusion (0.027-4.0 pmol min-1) of exogenous vasopressin were given for 10 min periods to conscious, Brattleboro (i.e. vasopressin-deficient) rats, which had been chronically instrumented with pulsed Doppler probes and intravascular catheters (to permit assessment of regional haemodynamic changes). 2. There were no significant effects of the two lowest rates of infusion (0.027 and 0.105 pmol min-1) but, after 10 min of vasopressin infusion at 0.313 pmol min-1, superior mesenteric vasoconstriction had occurred unaccompanied by any other changes. Infusion of vasopressin at 0.687 pmol min-1 produced increases in blood pressure and in both mesenteric and hindquarters vascular resistance, but not change in renal vascular resistance or heart rate. These results do not indicate specific interactions between exogenous vasopressin and baroreflex mechanisms to offset the pressor effect of the neuropeptide. 3. The marked bradycardia, hypertension and renal, mesenteric and hindquarters vasoconstriction seen after 10 min infusion of vasopressin at 4.0 pmol min-1 were all abolished 10 min after administration of an antagonist of V1-receptors [+)-(CH2)5Tyr(Et)DAVP); additional antagonism of V2-receptors (with the non-selective antagonist (+)-(CH2)5Tyr(Et)VAVP) had no effects on any measured variable. Hence, the present experiments provide no evidence for important vasodilator effect of vasopressin in conscious, Brattleboro rats. PMID:2524234

Gardiner, S M; Compton, A M; Bennett, T

1989-05-01

363

Effect of the volume of liquid food infused intragastrically on satiety in women.  

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This experiment examined whether food volume and energy content affected satiety in lean and obese women, when visual and oral cues were bypassed by infusing food intragastrically. The effects of volume and energy content were examined separately by using liquid foods that differed in energy density (kcal/g). On 5 separate days, 25 lean and 29 obese women consumed all of their meals in the laboratory. A nasogastric tube was inserted 30 min before lunch on 4 days; on three of these occasions, a liquid preload was infused for 15 min and, on the fourth occasion (control), the preload was diverted covertly. On the remaining day, no tube was inserted. The three preloads varied two-fold in volume and energy content: 200 ml/200 kcal, 400 ml/200 kcal and 400 ml/400 kcal. The results showed that increasing the volume of infused food, but not the energy content, affected satiety in both lean and obese women. There was a mean decrease in energy intake at lunch of 77 kcal (13%) after the 400-ml preload compared with the iso-energetic 200-ml preload (P=.013). Increasing the energy content of infused food, but not the volume, did not affect satiety. Thus, when sensory cues were bypassed, the volume of liquid food infused intragastrically affected subsequent energy intake in both lean and obese women. These results suggest that gastric and postgastric mechanisms are involved in the effects of high-volume, low-energy-dense foods on satiety. PMID:12127002

Rolls, Barbara J; Roe, Liane S

2002-08-01

364

Materials Characterisation and Analysis for Flow Simulation of Liquid Resin Infusion  

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Liquid Resin Infusion (LRI) processes including VARI and VARTM have received increasing attention in recent years, particularly for infusion of large parts, or for low volume production. This method avoids the need for costly matched metal tooling as used in Resin Transfer Moulding (RTM) and can provide fast infusion if used in combination with flow media. Full material characterisation for LRI analysis requires models for three dimensional fabric permeability as a function of fibre volume content, fabric through-thickness compliance as a function of resin pressure, flow media permeability and resin viscosity. The characterisation of fabric relaxation during infusion is usually determined from cyclic compaction tests on saturated fabrics. This work presents an alternative method to determine the compressibility by using LRI flow simulation and fitting a model to experimental thickness measurements during LRI. The flow media is usually assumed to have isotropic permeability, but this work shows greater simulation accuracy from combining the flow media with separation plies as a combined orthotropic material. The permeability of this combined media can also be determined by fitting the model with simulation to LRI flow measurements. The constitutive models and the finite element solution were validated by simulation of the infusion of a complex aerospace demonstrator part.

Sirtautas, J.; Pickett, A. K.; George, A.

2014-08-01

365

Copper complexing properties and physico-chemical characterisation of the organic matter in Greek herbal infusions.  

Science.gov (United States)

Complex formation is among the mechanisms affecting metals' bioaccessibility. Evaluating the extent of interactions between trace elements and several constituents of food items is of great interest. This paper examines the release of copper-complexing ligands in herbal infusions of 13 aromatic plants commonly used in Greece. The concentration of ligands (LT) and the copper-binding strength (logKapp) of herbal infusions were determined with Differential Pulse Anodic Stripping Voltammetry (DPASV). All herbal infusions were found to release Cu complexing ligands, at concentrations ranging from 8.8 to 112.5 ?M in rosemary and marjoram, respectively. In all infusions the total copper concentrations were lower than the corresponding LT values, indicating that Cu is fully complexed. Aiming to partially characterise the physico-chemical properties of the released organic material, the surface active substances (SAS), reduced sulphur species (RS) and catalytically active compounds (CAC) were measured, for the first time, in herbal infusions by sensitive electrochemical techniques. PMID:24799208

Karavoltsos, Sotirios; Plavši?, Marta; Kalogeropoulos, Nick; Kogiannou, Dimitra A A; Strme?ki, Sla?ana; Sakellari, Aikaterini; Dassenakis, Manos; Scoullos, Michael

2014-10-01

366

Antioxidant activity of oak (Quercus) leaves infusions against free radicals and their cardioprotective potential.  

Science.gov (United States)

The aim of present study was to evaluate antioxidant capacity and cardioprotective potential of leaves infusions and partially purified fractions of Quercus sideroxyla and Q. eduardii (red oaks) and Q. resinosa (white oak). Consumption of polyphenol-rich beverages derived from plants, such as oak may represent a beneficial diet in terms of cardiovascular protection. Infusions from Oak leaves were obtained and probed for total phenolics by Folin-Ciocalteu, DPPH and hydroxyl radicals scavenging by DPPH test and Deoxy-D-ribose method, the antioxidant capacity was evaluated by FRAP and ORAC tests, inhibitions of Low Density Lipoproteins (LDL) oxidation and Angiotensin Converting Enzyme (ACE) activity were measured. A HPLC analysis was performed by HPLC-MS. Bioactive polyphenols such as gallic and ellagic acids, catechin, quercetin and derivatives: naringenin and naringin were detected in Quercus infusions. A distinctive HPLC profile was observed among the red and white oak samples. Q. resinosa infusions have exhibited the highest antioxidant activity in comparison with the other species, although in the inhibition of LDL oxidation no differences were observed. In the inhibition of the ACE, Q. resinosa was more effective (IC50, 18 ppm) than Q. sideroxyla, showing same effect as the control Captopril. From the results it is possible to postulate that not only chelating activity is important in these infusions, especially in Q. resinosa. PMID:21848067

Rivas-Arreola, M J; Rocha-Guzmán, N E; Gallegos-Infante, J A; González-Laredo, R F; Rosales-Castro, M; Bacon, J R; Cao, Rong; Proulx, A; Intriago-Ortega, P

2010-06-01

367

Plastic particle migration during intravenous infusion assisted by a peristaltic finger pump in an animal model.  

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The contamination of intravenously administered fluid with foreign material has always been of major concern, but the in-vivo impact of silicone embolisation from administration of fluid via a peristaltic finger pump (PFP) has not previously been assessed. To determine whether silicone particles enter the lungs and to review the histological response, 10 rabbits received an IV infusion of 0.9% saline at 10 ml/kg per hour over a 72-h period, via an IVAC 591 PFP. The lungs were analysed for silicone particles with scanning electron microscopy (SEM) and energy-dispersive X-ray analysis (EDXA). These results were compared with a control group of non-infused animals. Silicone particles were found in 8 of 10 animals in the experimental group and in 2 of 9 control animals, indicating that silicone particles are dislodged during pump-assisted IV infusions. The difference between the control and infused animals was statistically significant using Fisher's exact test (P = 0.023). However, silicone plastic particles in control animals suggest that there is also environmental exposure to silicone in addition to those particles that come from a therapeutic source. The additional finding of elemental silicon (which is one of the constituents of silicone plastic) in both infused and control animals in which silicone plastic was not found indicates that not all elemental silicon in animals reflects the presence of silicone plastic. The clinical significance of each of these two findings is yet to be determined. PMID:12415345

Dewan, P A; Ehall, H; Edwards, G A; Middleton, D J; Terlet, J

2002-09-01

368

Thrombotic complications of subclavian apheresis catheters in cancer patients: prevention with heparin infusion.  

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Twenty-two silicone rubber apheresis catheters were placed into the subclavian veins of 18 cancer patients to allow serial leukapheresis for collection of circulating hematopoietic stem cells. The tips of the catheters were placed in the innominate vein to avoid reinfusion of citrate into the right atrium and the resulting tendency to cardiac arrhythmias. Sixteen catheters were placed without prophylactic anticoagulation. Anticoagulation was prematurely discontinued in one patient because of the inconvenience of the portable heparin infusion pump. Six of these 17 catheters developed venographically proven thrombotic complications and five others had presumed thrombosis-related access failure or caused symptoms of venous obstruction, but confirmation of the presence of a thrombus with venography was not obtained. Three catheters spontaneously withdrew from the vein, one during urokinase infusion for thrombosis. Only three catheters had uncomplicated apheresis courses. Prophylactic heparin infusions via portable infusion pumps were given after placement of six catheters. As long as the heparin infusions were continued all patients had uncomplicated apheresis courses. One patient's heparin was prematurely discontinued. Within 3 days of its discontinuance, radiographically proven thrombotic catheter occlusion occurred. Patients given heparin were less likely to develop complications (P less than 0.001). No unexpected complications of apheresis were encountered as a result of the use of these catheters. Silicone rubber subclavian catheters can be used for peripheral stem cell collection but have a high frequency of thrombotic complications. Systemic anticoagulation with heparin can minimize the likelihood of these complications. PMID:2228997

Haire, W D; Edney, J A; Landmark, J D; Kessinger, A

1990-01-01

369

Low flow measurement for infusion pumps: implementation and uncertainty determination of the normalized method  

International Nuclear Information System (INIS)

Intravenous drug delivery is a standard practice in hospitalized patients. As the blood concentration reached depends directly on infusion rate, it is important to use safe devices that guarantee output accuracy. In pediatric intensive care units, low infusion rates (i.e. lower than 10.0 ml/h) are frequently used. Thus, it would be necessary to use control programs to search for deviations at this flow range. We describe the implementation of a gravimetric method to test infusion pumps in low flow delivery. The procedure recommended by the ISO/IEC 60601-2-24 standard was used being a reasonable option among the methods frequently used in hospitals, such as infusion pumps analyzers and volumetric cylinders. The main uncertainty sources affecting this method are revised and a numeric and graphic uncertainty analysis is presented in order to show its dependence on flow. Additionally, the obtained uncertainties are compared to those presented by an automatic flow analyzer. Finally, the results of a series of tests performed on a syringe infusion pump operating at low rates are shown.

370

Low flow measurement for infusion pumps: implementation and uncertainty determination of the normalized method  

Science.gov (United States)

Intravenous drug delivery is a standard practice in hospitalized patients. As the blood concentration reached depends directly on infusion rate, it is important to use safe devices that guarantee output accuracy. In pediatric intensive care units, low infusion rates (i.e. lower than 10.0 ml/h) are frequently used. Thus, it would be necessary to use control programs to search for deviations at this flow range. We describe the implementation of a gravimetric method to test infusion pumps in low flow delivery. The procedure recommended by the ISO/IEC 60601-2-24 standard was used being a reasonable option among the methods frequently used in hospitals, such as infusion pumps analyzers and volumetric cylinders. The main uncertainty sources affecting this method are revised and a numeric and graphic uncertainty analysis is presented in order to show its dependence on flow. Additionally, the obtained uncertainties are compared to those presented by an automatic flow analyzer. Finally, the results of a series of tests performed on a syringe infusion pump operating at low rates are shown.

Cebeiro, J.; Musacchio, A.; Fernández Sardá, E.

2011-12-01

371

Cesarean Section Birth  

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Full Text Available ... need a lot of special help. So it's real important when c-sections are performed that we ... cesarean sections, particularly if the patient's had a number of repeat cesarean sections. And there are also ...

372

Cesarean Section Birth  

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Full Text Available ... a cesarean section with her last delivery. Other common reasons for cesarean sections are when we can ... to fit through the birth canal, that's another common reason for cesarean section. Other less common reasons ...

373

C-Section  

Medline Plus

Full Text Available ... Cesarean section, or C-section, is the surgical delivery of a baby through an incision in the ... via C-sections. That is around a million deliveries a year! This reference summary is about C- ...

374

Shifting Perspectives and Practices: Teacher Candidates’ Experiences of a First Nation, Métis, and Inuit Infusion in Mainstream Teacher Education  

Directory of Open Access Journals (Sweden)

Full Text Available This exploratory case study shares teacher candidates’ perspectives and experiences of the First Nation, Métis, and Inuit Infusion at ABC University’s Faculty of Education field site in XYZ, Ontario. For this initiative, Aboriginal content and pedagogies were infused throughout placements and courses of the mainstream teacher education program. Teacher candidates shared that the Infusion prepared them to teach Aboriginal content in culturally respectful and meaningful ways by providing them with a foundation to build on and helping them to develop teaching practices inclusive of diverse ways of knowing and being in the world. These findings may be useful to other educators developing and implementing their own infusion initiatives.

Melissa Marilyn Fern Blimkie

2014-10-01

375

Attractiveness of botanical infusions to ovipositing Culex quinquefasciatus, Cx. nigripalpus, and Cx. erraticus in San Antonio, Texas.  

Science.gov (United States)

Field experiments were conducted on the Fort Sam Houston Military Reservation, San Antonio, TX, in fall 2008 to observe the attractiveness of selected botanical infusions to ovipositing female mosquitoes. The following infusions were tested in Centers for Disease Control and Prevention gravid traps: Bermuda grass (Cynodon dactylon), oak leaf (Quercus virginiana), acacia leaf (Acacia schaffneri), rabbit chow (alfalfa pellets), and algae (Spirogyra sp.). Four (Bermuda, acacia, oak, and algae) of the 5 infusions were effective in collecting Culex quinquefasciatus, Cx. nigripalpus, and Cx. erraticus. Of the 4 infusions, Bermuda collected the greatest number of the mosquitoes sampled. Female Aedes albopictus mosquitoes were collected in moderate numbers during this study. PMID:20099599

McPhatter, Lee P; Debboun, Mustapha

2009-12-01

376

21 CFR 526.1696b - Penicillin G procaine-dihydrostreptomycin in soybean oil for intramammary infusion (dry cows).  

Science.gov (United States)

...RELATED PRODUCTS INTRAMAMMARY DOSAGE FORMS ...soybean oil for intramammary infusion (dry...Indications for use. Intramammary treatment of...specifically against infections caused by Staphylococcus aureus and...

2010-04-01

377

Risk of ventricular dysrhythmias during 1-hour infusions of amphotericin B in patients with preserved renal function.  

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In order to assess the safety of 1-h infusions of amphotericin B (AMB), we prospectively monitored 213 1-h infusions of AMB (dose range, 0.27 to 0.89 mg/kg of body weight) in 27 patients with creatinine clearances of > 25 ml/min. Holter monitor tracings during 1-h infusions were compared with those during a 4-h baseline period of monitoring. There were no ventricular dysrhythmias during 1-h infusions of AMB that were not present during baseline monitoring. Nausea and/or rigors were noted for ...

Bowler, W. A.; Weiss, P. J.; Hill, H. E.; Hoffmeister, K. A.; Fleck, R. P.; Blacky, A. R.; Oldfield, E. C.

1992-01-01

378

Application of saline infusion sonography in the diagnosis of endometrial polyps  

Directory of Open Access Journals (Sweden)

Full Text Available Endometrial polyps represent benign focused growths of endometrium with the prevalnece of 5-10 in 100 patients older than 30 years of age. The most frequent symptom is irregular uterine bleeding. Saline Infusion Sonography (SIS is the least invasive and the simplest method for detection of an abnormality of the uterine cavity. In this paper we have presented a case of a65- year old patient with endometrial polypus, irregular uterine bleeding referred to hyperplasia endometria as a working diagnosis. Using the Saline Infusion Sonography check-up the diagnosis of endometrial polypus was established including its localization, diameter and other diagnostic parameters. The results of this study have shown that the Saline Infusion Sonography provides more information about the state of uterocervical cavity as compared to the standard transvaginal sonography.

K. Drljevi?

2006-08-01

379

Continuous subcutaneous infusion of lidocaine for persistent hiccup in advanced cancer.  

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Persistent hiccup can cause anorexia, weight loss, disabling sleep deprivation, anxiety, and depression. Therefore, relief of persistent hiccup is important for advanced cancer patients and their family. Most reports on this condition are case series reports advocating the use of baclofen, haloperidol, gabapentin, and midazolam. However, these medications are occasionally ineffective or accompanied by intolerable side effects. The sodium channel blocker lidocaine has been shown to be effective in treating a variety of disorders thought to involve neuropathic mechanisms. Intravenous administration of lidocaine is common but efficacy has also been reported for subcutaneous infusion. In advanced cancer patients, subcutaneous infusion is easy, advantageous, and accompanied by less discomfort. We report a case of severe and sustained hiccup caused by gastric cancer that was successfully treated with a continuous subcutaneous infusion of lidocaine (480 mg (24 ml)/day) without severe side effects. PMID:22661318

Kaneishi, Keisuke; Kawabata, Masahiro

2013-03-01

380

Superselective cerebral arterial infusion of BCNU in high-grade glioma: The radiologist's point of view  

International Nuclear Information System (INIS)

Twenty-seven patients with high-grade glioma were candidates for superselective cerebral infusion of BCNU after surgery and radiation therapy. A total of 59 catheterizations were undertaken using an 8-F guiding catheter through which a 2.5 F balloon catheter was propelled into the main arterial trunk feeding the tumor. Ten procedures were stopped because of arterial spasm with transient deficit or prolonged catheterization time. Forty-nine infusions of 150-200 mg of BCNU were carried out, each lasting 3 hours. In 75% of patients, stabilization or improvement was noted on CT scan 5 weeks after treatment. This study demonstrates the safety of supraophthalmic catheterization, the feasibility of prolonged catheterization, and the relative effectiveness of low-dose BCNU infused over a long period of time

 
 
 
 
381

Clinical study on external carotid artery infusion (trans-femoral) treatment of recurrent nasopharyngeal carcinoma  

International Nuclear Information System (INIS)

Objective: To evaluate the effect and safety of external carotid artery infusion treatment of recurrent nasopharyngeal carcinoma (NPC). Methods: 20 cases of recurrent NPC (13 male and 7 female, age 36-65 years, mean 50 years) diagnosed by clinical examination (including nasopharyngoscope), serology (VCA-IgA) and imaging (CT, MR) and treated by external carotid artery infusion (trans-femoral) with adriamycin (or epi-adriamycin), cisplatin (or carboplatin), Pingyangmycin and 5-Fluorouracil. Results: Of all the patients, 8 cases (40%) had a complete response (CR), 7 cases (35%) had a partial response (PR). The overall response rate (CR + PR) was 75%. Cumulative survival rates at 1, 3 years were 90% (18/20), 50%(10/20) respectively. No severe side-effects and complications found. Conclusion: External carotid artery infusion (trans-femoral) should be effective and safe in the treatment of recurrent NPC

382

A {sup 82}Rb infusion system for quantitative perfusion imaging with 3D PET  

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A {sup 82}Rb infusion system is described with two important features for imaging with 3D positron emission tomography. First, a generator bypass line is added to flush the patient infusion line at the end of an elution. Second, feedback control is implemented to permit 'slow-bolus' constant-activity elutions. A model for the activity eluted from a {sup 82}Sr/{sup 82}Rb generator based on a volume-activity empirical relationship, is used as the basis for performing simulations to demonstrate the efficacy of varying the flow rate through the generator to achieve desired eluted {sup 82}Rb activity rate profiles. A {sup 82}Rb infusion system was constructed to verify the accuracy of the simulations. The system can deliver accurate constant-activity elutions from 10% to 70% of the total generator activity.

Epstein, Neil J.; Benelfassi, Ahmed; Beanlands, S.R.; Kemp, R.A. de E-mail: radekemp@ottawaheart.ca

2004-06-01

383

Selective intra arterial infusion chemotherapy for malignant nasal and paranasal sinus tumors  

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Since 1998, we have treated 14 malignant nasal and paranasal sinus tumor patients with selective intra arterial infusion chemotherapy. We report results for 7 of maxillary sinus, 3 of sphenoid sinus 1 of ethmoid sinus, and 3 of the nasal cavity. Only 1 maxillary sinus case involved recurrence. Intra arterial infusions of cisplatin (100 mg/body) was delivered rapidly to the tumor and usually repeated for 4 times. Conventional external-beam irradiation (2 Gy per fraction x 30) was also used. Complete response cases were 9 of 14 and control of the local lesion found in all new cases. These results indicate that intra arterial infusion therapy is effective against advanced malignant nasal and paranasal sinus tumors. (author)

Miyajima, Yoshimi; Nakashima, Tadashi; Hayabuchi, Naofumi; Abe, Toushi; Tanaka, Norimitsu [Kurume Univ., Fukuoka (Japan). School of Medicine

2003-04-01

384

[Treatment of resistance to subcutaneous insulin with implanted insulin infusion pumps].  

Science.gov (United States)

Four female patients, resistant to insulin administered subcutaneously, were treated with an implanted insulin infusion pump (Infusaid; constant rate infusion). They had all experienced as many as four episodes of ketoacidosis per month despite extremely high doses of insulin injected subcutaneously or intramuscularly, and none of the treatment approaches attempted--insulin delivery via subclavian catheter, Schade-port, insulin infusion with an external portable pump or various insulin additives--had been successful. After implantation of the pump the daily insulin dose, which had been between 300 and 3000 units during subcutaneous therapy, was reduced to 30 to 70 units per day. The patients' condition improved, no further episodes of ketoacidosis occurred and hospital stays were reduced significantly. In the further course of treatment pump and catheter-related complications had to be overcome. PMID:3138098

Löchli, S; Campbell, I; Dorenboos, H; Paterson, K R; Devlin, J G; Hagmüller, G; Irsigler, K

1988-09-01

385

Effect of intravenous infusion of isotonic sodium bicarbonate solution on acidemic calves with diarrhea.  

Science.gov (United States)

The effect of 1.35% isotonic sodium bicarbonate solution (ISB) administered intravenously on acid-base equilibrium was examined in 18 acidemic Japanese black beef calves with spontaneous diarrhea. The infusion volumes of ISB were decided based on the first half volumes of base needed. In 72.2% (13/18) of calves, improvement of acidemia was detected. There was good correlation (r=0.693, p<0.01) between infused volume of ISB and changes in base excess (y=1.097x + 4.762). Infusion volumes of ISB were 7.5, 10.2, 12.9 and 15.7 ml/kg, respectively, enough to correcting the first half of 5, 10, 15 and 20 mEq/l of base deficit in acidemic calves. Our finding suggested that ISB could be used to correct metabolic acidosis without altering electrolyte concentrations in calves. PMID:12520117

Suzuki, Kazuyuki; Kato, Tosihide; Tsunoda, Gensei; Iwabuchi, Shigehiro; Asano, Kimi; Asano, Ryuji

2002-12-01

386

Electromagnetic interference to infusion pumps. Update2008 from GSM mobile phones.  

Science.gov (United States)

Electromagnetic interference (EMI) to critical care medical devices has been reported by various groups. Previuos study demonstrated that infusion pumps are susceptible of false alarm buzzing and block of infusion, when exposed to various EMI sources. Aim of this paper is to investigate the changes in the risk of EMI from the estimates of our previous 2005 survey and to extend the EMI risk assessment to newer telecommunication products: DECT phones and WiFi terminals. With regards to GSM phones, compare to the results obtained in 2005, we observed a decrease in the rate of failure (from 58% to 30%). From our findings, the use of WiFi and DECT does not pose a real risk to infusion systems. PMID:19163716

Calcagnini, G; Censi, F; Triventi, M; Mattei, E; Losterzo, R; Marchetta, E; Bartolini, P

2008-01-01

387

Selective intra arterial infusion chemotherapy for malignant nasal and paranasal sinus tumors  

International Nuclear Information System (INIS)

Since 1998, we have treated 14 malignant nasal and paranasal sinus tumor patients with selective intra arterial infusion chemotherapy. We report results for 7 of maxillary sinus, 3 of sphenoid sinus 1 of ethmoid sinus, and 3 of the nasal cavity. Only 1 maxillary sinus case involved recurrence. Intra arterial infusions of cisplatin (100 mg/body) was delivered rapidly to the tumor and usually repeated for 4 times. Conventional external-beam irradiation (2 Gy per fraction x 30) was also used. Complete response cases were 9 of 14 and control of the local lesion found in all new cases. These results indicate that intra arterial infusion therapy is effective against advanced malignant nasal and paranasal sinus tumors. (author)

388

PENGARUH INFUS BEBERAPA TANAMAN OBAT TERHADAP TEKANAN DARAH DAN FAAL JANTUNG KUCING  

Directory of Open Access Journals (Sweden)

Full Text Available The 10 percent infusion of Sericoccalyx crispus BL administered intravenously at dose 1 ml/kg did not alter the cardiovascular system of the anaesthetized cat. Piper betle LINN and Euphatorium triplinerve VAHL at the same dose of administration decreased the blood pressure with short onset and duration. One milliliter of a 10 percent infusion of Curcuma domestica VAHL decreased the blood pressure of the anaesthetized cat slowly and lasting about 3 hours reaching its maximal depression at one hour after injection. The action on the heart rate, contractility and autonomic ganglion is not clear. A direct action, after reaction of substance or after formation of a substance, on the blood vessels is sugested to be the most probable mechanism of action of this crude infusion of Curcuma domestica.

B. Dzulkarnain

2012-09-01

389

PENGARUH INFUS DAUN PLANTAGO MAYOR L (DAUN URAT PADA UTERUS TIKUS YANG DIOVAREKTOMI  

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Full Text Available Secara empiris daun Plantigo mayor L (daun urat digunakan untuk obat tidur teratur datang haid. Berdasarkan pemakaian tersebut, diduga daun Plantigo mayor L dapat mempengaruhi sistem reproduksi termasuk organ reproduksi. Oleh karena itu, dilakukan penelitian pengaruh infus daun Plantigo mayor L terhadap uterus pada tikus yang diovarektomi untuk membuktikan adanya pengaruh terhadap organ reproduksi, terutama uterus. Infus diberikan secara oral dengan dosis 7,5mg ; 75mg dan 225mg/100g bobot badan dan sebagai blangko diberikan akuades dengan volume dosis 1 kl/100g bobot badan yang juga diberikan secara oral. Perlakuan diberikan setiap hari selama 7 hari. Hasil penelitian menunjukkan bahwa infus daun Plantigo mayor L dosis 7,5mg/100g bobot badan dapat menghambat atrofi uterus pada tikus yang diovarektomi.

Sa'roni Sa'roni

2012-10-01

390

Model Predictive Control of Drug Infusion System for Mean Arterial Pressure Regulation of Critical Care Patients  

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Full Text Available Patients recovering in critical care units are continuously monitored for their hemodynamic states and accordingly given proper medication. The widely monitored hemodynamic variable is the Mean Arterial Pressure (MAP, which is regulated by infusion of vasoactive drugs like Sodium Nitroprusside (SNP. Presently, physicians check the patients’ MAP at regular intervals. This task is time-consuming and if automated, allows the physicians to attend to other critical parameters, which cannot be measured. Automation of the drug infusion based on the MAP would lead to continuous regulation of the hemodynamic variable enabling speedier recovery. This study attempts to automate the regulation of the drug infusion system using a model predictive controller. The controller’s performance was tested for three types of patient models. The controller tracks the set point changes and maintains the mean arterial pressure within the required values.

S.A. Nirmala

2014-05-01

391

Thallium-201 myocardial single photon emission computed tomography after isoproterenol infusion in diagnosing ischemia heart disease  

International Nuclear Information System (INIS)

Patients with obstructive atherosclerotic disease of the peripheral arteries are often unable to undergo a standard Treadmill test for evaluation of concomitant coronary artery diseases. To establish an alternative method of testing, 27 patients had intravenous infusion of isoproterenol, up to 1.0 ?g/kg, in conjugation with myocardial thallium-201 single photon emission computed tomography (SPECT). All underwent coronary angiography. Thallium-201 myocardial SPECT after isoproterenol infusion was found to have 100 % sensitivity and 100 % specificity for detecting coronary artery diseases (stenotic or occluded coronary arteries with or without myocardial infarction) and 87 % sensitivity and 100 % specificity for detecting stenotic coronary arteries with viable regional myocardium. No major complication was experienced during and after this study. It is concluded that serial thallium-201 myocardial SPECT after isoproterenol infusion is safe, reliable and useful for detecting coronary artery disease when standard exercise test is not feasible. (author)

392

Treatment of lung cancer with bronchial artery infusion of cisplatin and intravenous sodium thiosulfate rescue  

Energy Technology Data Exchange (ETDEWEB)

Forty-nine patients with primary lung cancer were treated with bronchial artery infusion of cisplatin and intravenous injection of an antidote, sodium thiosulfate. More than 50% reduction of tumor size (PR) was observed in 8 of 9 small cell carcinomas (SCLC) and in 16 of 40 non-small cell carcinomas (NSCLC). In NSCLC patients PR was obtained in 71% (12/17) after repeated infusions (greater than or equal to 200 mg cisplatin) and in 17% (4/23) after a single infusion (less than or equal to 150 mg cisplatin). There was a significant linear relationship between cisplatin dose and tumor reduction in this group. No severe adverse effects were encountered.

Uchiyama, N.; Kobayashi, H.; Nakajo, M.; Shinohara, S.

1988-01-01

393

[Residual pesticide concentrations after processing various types of tea and tea infusions].  

Science.gov (United States)

The effects of processing to produce various types of tea or infusion on the levels of pesticide residues in tea were investigated for three insecticides (chlorfenapyr, pyrimiphos-methyl, and clothianidin). Tea plants were sprayed with one of the three pesticides and cultivated under cover. The levels of pesticide residues in tea decreased after processing according to the time and temperature of heating, as well as fermentation. Although significant differences were not observed among the three pesticides in the ratio of decreased of pesticide concentration after processing to green tea, clothianidin, which is a neonicotinoid insecticide and has a lower log Pow value, tended to be transferred more than the other two insecticides into infusions. However, no significant difference in the ratios of clothianidin transferred to infusions was observed among green tea with three different leaf sizes. PMID:24025203

Kondo, Takahide; Watanabe, Ayaka; Shitara, Hiroshi; Kaburagi, Yasuo; Shibata, Masahisa; Kanda, Noriko; Kurokawa, Chieko; Inoue, Yutaka; Miyazaki, Motonobu; Togawa, Masayuki; Ozawa, Akihito; Uchiyama, Toru; Koizumi, Yutaka; Nakamura, Yoriyuki; Masuda, Shuichi; Maitani, Tamio

2013-01-01

394

Immersion Condensation on Oil-Infused Heterogeneous Surfaces for Enhanced Heat Transfer  

Science.gov (United States)

Enhancing condensation heat transfer is important for broad applications from power generation to water harvesting systems. Significant efforts have focused on easy removal of the condensate, yet the other desired properties of low contact angles and high nucleation densities for high heat transfer performance have been typically neglected. In this work, we demonstrate immersion condensation on oil-infused micro and nanostructured surfaces with heterogeneous coatings, where water droplets nucleate immersed within the oil. The combination of surface energy heterogeneity, reduced oil-water interfacial energy, and surface structuring enabled drastically increased nucleation densities while maintaining easy condensate removal and low contact angles. Accordingly, on oil-infused heterogeneous nanostructured copper oxide surfaces, we demonstrated approximately 100% increase in heat transfer coefficient compared to state-of-the-art dropwise condensation surfaces in the presence of non-condensable gases. This work offers a distinct approach utilizing surface chemistry and structuring together with liquid-infusion for enhanced condensation heat transfer.

Xiao, Rong; Miljkovic, Nenad; Enright, Ryan; Wang, Evelyn N.

2013-06-01

395

Infliximab drug and infusion costs among patients with Crohn's disease in a commercially-insured setting.  

Science.gov (United States)

Significant attention has been paid to the cost of treating patients with anti-TNF agents for diseases including Crohn's disease (CD). To evaluate the actual expenditures for infliximab in routine clinical practice, the authors examined patterns of administration and reimbursement among commercially-insured patients receiving infliximab for CD. Integrated pharmacy and medical claims data were obtained from 78 US health plans. Data from CD patients treated with infliximab between June 2000 and December 2003 were analyzed. Each claim for an infusion (HCPCS code J1745) represented a single observation. Descriptive statistics were generated for the number of vials billed for each infusion, total charged amount (ie, the amount submitted by providers), and total paid amount (ie, the amount reimbursed by the health plan, net of any patient copayment, coinsurance, or deductible). A total of 2230 CD patients were identified; of the original total of 9724 infusions, 168 were not evaluable because of data quality issues, yielding cost evaluation for 9556 total infusions. At each infusion, claims for a mean (SD) of 4.79 (1.74) vials were submitted (median = 5). Corresponding charged amounts were 4441 dollars (1778 dollars) (median = 4099 dollars); paid amounts averaged 2793 dollars (990 dollars) (median = 2628 dollars). Charged and paid amounts per vial billed averaged 927 dollars and 583 dollars, respectively. The average cost of administering a dose of infliximab to a commercial insurer is approximately 2800 dollars. Assumptions regarding infusion costs for infliximab based on charged amounts may be misleading; the true costs of administering infliximab in routine practice are likely to be lower than that reported for charged amounts. PMID:17122530

Ollendorf, Daniel A; Lidsky, Loren

2006-01-01

396

Tracer measured substrate turnover requires arterial sampling downstream of infusion site  

International Nuclear Information System (INIS)

Measurement of metabolite turnover (Rt) with radioactive tracers is done by either infusing tracer venously and sampling specific activity (SA) arterially (V-A modes), or by infusing into the aorta and sampling venous blood (A-V mode). Using the Fick principle, the necessity for using the V-A mode can be demonstrated. If tracer is infused into the left ventricle, in a steady state the Rt is the product of arterial trace concentration, the cardiac output, and the tracer extraction ratio for the whole body. This is expressed as: Rt = Ca x Qx ((*Ca - *Cv)/*Ca) (Eq1) where C=trace concentration (?mol/ml), *C=tracer conc. (dpm/ml), a=arterial, v-=mixed venous, and Q=cardiac output (ml/min). Rearranging the equation: Rt = Qx(*Ca - *Cv)/SAa = F/SAa (Eq2) where SAa is *Ca/Ca, and Qx (*Ca-*Cv) equals the infusion rate (F). The authors compared Eqs1 and 2 (Rt = F/SAa) in 3 anesthetized dogs in which [1-14C] lactate was infused into the left ventricle, and blood was sampled arterially downstream from the infusion site and in the pulmonary artery. Eqs 1 and 2 gave similar results for Rt (45.9 vs. 43.9 ?mol/kg min), while substituting SAv for SAa (A-V mode) into Eq 2 gave a higher Rt (53.6). When SAv (A-V mode) is used, the specific activity seen by the tissues (SAa) is not considered in the calculation of Rt. Therefore, only the V-A mode meets the requirements for tracer measured metabolite turnover

397

Severe infusion reactions to infliximab: aetiology, immunogenicity and risk factors in patients with inflammatory bowel disease  

DEFF Research Database (Denmark)

BACKGROUND: Infliximab (IFX) elicits acute severe infusion reactions in about 5% of patients with inflammatory bowel disease (IBD). AIM: To investigate the role of anti-IFX antibodies (Ab) and other risk factors. METHODS: The study included all IBD patients treated with IFX at a Danish university hospital until 2010 either continuously (IFX every 4-12 weeks) or episodically (reinitiation after >12 weeks). Anti-IFX Ab were measured using radioimmunoassay. RESULTS: Twenty-five (8%) of 315 patients experienced acute severe infusion reactions. Univariate analysis showed that patients who reacted were younger at the time of diagnosis (19 vs. 26 years, P=0.013) and at first IFX infusion (28 vs. 35 years, P=0.012). Furthermore, they more often received episodic therapy (72% vs. 31%, P<0.001) and logistic regression revealed this as the only significant predictor of reactions (OR 5 [2-13]; P<0.001). IFX reinitiation after 6 months intermission further increased the risk (OR 8 [3-20], P<0.001). Most reactions (n=14, 88%) occurred at 2nd infusion in the 2nd treatment series (P=0.006). Anti-IFX IgG Ab were highly positive in 19 of 20 patients (95%) shortly after the reactions (median 84 U/mL). Anti-IFX IgG Ab measured prior to the retreatment series were negative in 7 of 11 patients tested (64%). Anti-IFX IgE Ab were negative in all patients with reactions. CONCLUSIONS: Acute severe infusion reactions were strongly associated with development of anti-IFX IgG Ab, but not with anti-IFX IgE Ab. The risk was particularly high at the 2nd infusion in retreatment series. Negative anti-IFX Ab before reinitiation did not rule out reactions.

Steenholdt, Casper; Svenson, M

2011-01-01

398

Intramammary Honey Infusion: A New Trend in the Management of Bovine Subclinical Mastitis  

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Full Text Available The objective of this study was to determine the most suitable and effective regimen of intramammary honey infusion in bovine subclinical mastitis. A total of twenty five subclinical mastitic cows from two farms were divided into two groups; group a: 10 lactating cows were infused 10 mL fennel honey solution 10% in sterile saline/quarter daily for three successive doses; group b: 15 lactating cows were infused day by day for three successive doses guarded with intramuscular antihistaminic drug. Milk samples of both groups showed a decrease in total bacterial count at the 3rd and 10th day and the reduction percent was 99.6 and 99.8%, respectively. Milk cytological results showed a significant increase (p<0.05 in lymphocyte and significant (p<0.05 decrease in neutrophil percentages at the 3rd day up to the 10th day in group b while the same results were achieved at the 10th day in group a. Milk yield records in group a showed decrease by the 3rd day post intramammary infusion and then gradually increased up to the 10th day reaching nearly the same levels. Milk yield of group b showed a slight decrease by the 3rd day and gradually increased to level higher than that before infusion. Haematological study revealed that the percentage of blood neutrophil significantly decreased (p<0.05 from the 3rd up to the 10th day in both groups while the lymphocytic percentage increased significantly (p<0.05. In group a, the eosinophil cells’ percentage was significantly increased (p<0.05 at the 3rd day. It was concluded that intramammary 10% honey infusion day by day for three doses guarded by antihistaminic drug could treat bovine subclinical mastitis. Moreover, milk cytology could be used instead of California mastitis test during and after treatment with honey.

M.R. Abd Ellah

2011-01-01

399

Blood flow in human adipose tissue after infusion of (Gln4)-neurotensin.  

Science.gov (United States)

(Gln4)-neurotensin, 18 pmolXkg-1Xmin-1, was infused i.v. during 20 min in 10 healthy male volunteers. Adipose tissue blood flow was continuously monitored by measuring the disappearance rate of 99mTc-pertechnetate injected s.c. on the abdomen and thigh. Heart rate and blood pressure were measured and calf blood flow studied by venous occlusion plethysmography. Neurotensin-like immunoreactivity (NTLI) in serum was determined. Infusion of isotonic saline served as control. During intravenous infusion of (Gln4)-neurotensin the first order rate constants of 99mTc-pertechnetate from the abdomen decreased by 21.9 +/- 5.9% from a basal value of 8.3 +/- 0.5% min-1 (p less than 0.01). The reduction in blood flow started after a latent period of 5-10 min and persisted throughout the thirty minute observation period following infusion. A significant correlation (r=0.87, p less than 0.001) was found between the percentage decrease in blood flow from abdominal fat and the body fat content of the subjects as determined from the sum of four skinfolds. Blood flow from thigh fat did not change significantly, nor did heart rate, blood pressure or calf blood flow. During infusion of (Gln4)-neurotensin plasma neurotensin-like immunoreactivity (NTLI) increased successively. Ten minutes after starting the infusion the mean plasma NTLI level had increased from 20 +/- 5 pM to 302 +/- 31 pM; at 20 min it was 473 +/- 51 pM. These concentrations are within the range found after eating a fatty meal. The results indicate that neurotensin plays a physiological role in the regulation of human adipose tissue blood flow and may be of importance for the postprandial uptake of substrates in adipose tissue in certain regions. We suggest that neurotensin deserves consideration as an endocrine hormone affecting the regional deposition of fat postprandially. PMID:7180527

Linde, B; Rosell, S; Rökaeus, A

1982-07-01

400

Airway Hyperresponsiveness Induced by Repeated Esophageal Infusion of HCl in Guinea Pigs.  

Science.gov (United States)

Gastroesophageal reflux is a common disorder closely related to chronic airway diseases, such as chronic cough, asthma, chronic bronchitis, and chronic obstructive disease. Indeed, gastroesophageal acid reflux into the respiratory tract causes bronchoconstriction, but the underlying mechanisms have still not been clarified. This study aimed to elucidate functional changes of bronchial smooth muscles (BSMs) isolated from guinea pigs in an animal model of gastroesophageal reflux. The marked airway inflammation, hyperresponsiveness and remodeling were observed after guinea pigs were exposed to intraesophageal HCl infusion for 14 days. In addition, contractile responses to acetylcholine (ACh), KCl, electrical field stimulation, and extracellular Ca(2+) were greater in guinea pigs infused with HCl compared with control groups. The L-type voltage-dependent Ca(2+) channels (L-VDCC) blocker, nicardipine, significantly inhibited ACh- and Ca(2+)-enhanced BSM contractions in guinea pigs infused with HCl. The Rho-kinase inhibitor, Y27632, attenuated ACh-enhanced BSM contractions in guinea pigs infused with HCl. Moreover, mRNA and protein expressions for muscarinic M2 and M3 receptors, RhoA, and L-VDCC in BSM were detected by real-time PCR and Western blot. Expressions of mRNA and protein for muscarinic M3 receptors, RhoA, and L-VDCC were greater than in BSM of HCl-infused guinea pigs, whereas levels of muscarinic M2 receptors were unchanged. We demonstrate that acid infusion to the lower esophagus and, subsequently, microaspiration into the respiratory tract in guinea pigs leads to airway hyperresponsiveness and overactive BSM. Functional and molecular results indicate that overactive BSM is the reason for enhancement of extracellular Ca(2+) influx via L-VDCC and Ca(2+) sensitization through Rho-kinase signaling. PMID:24828018

Cheng, Yan-Mei; Cao, Ai-Li; Zheng, Jian-Pu; Wang, Hong-Wei; Sun, Yong-Shun; Liu, Chun-Fang; Zhang, Bei-Bei; Wang, Yi; Zhu, Sheng-Liang; Wu, Da-Zheng

2014-11-01