WorldWideScience
1

Study Protocol. ECSSIT – Elective Caesarean Section Syntocinon® Infusion Trial. A multi-centre randomised controlled trial of oxytocin (Syntocinon® 5 IU bolus and placebo infusion versus oxytocin 5 IU bolus and 40 IU infusion for the control of blood loss at elective caesarean section  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Caesarean section is one of the most commonly performed major operations in women throughout the world. Rates are escalating, with studies from the United States of America, the United Kingdom, China and the Republic of Ireland reporting rates between 20% and 25%. Operative morbidity includes haemorrhage, anaemia, blood transfusion and in severe cases, maternal death. The value of routine oxytocics in the third stage of vaginal birth has been well established and it has been assumed that these benefits apply to caesarean delivery as well. A slow bolus dose of oxytocin is recommended following delivery of the baby at caesarean section. Some clinicians use an additional infusion of oxytocin for a further period following the procedure. Intravenous oxytocin has a very short half-life (4–10 minutes therefore the potential advantage of an oxytocin infusion is that it maintains uterine contractility throughout the surgical procedure and immediate postpartum period, when most primary haemorrhages occur. The few trials to date addressing the optimal approach to preventing haemorrhage at caesarean section have been under-powered to evaluate clinically important outcomes. There has been no trial to date comparing the use of an intravenous slow bolus of oxytocin versus an oxytocin bolus and infusion. Methods and design A multi-centre randomised controlled trial is proposed. The study will take place in five large maternity units in Ireland with collaboration between academics and clinicians in the disciplines of obstetrics and anaesthetics. It will involve 2000 women undergoing elective caesarean section after 36 weeks gestation. The main outcome measure will be major haemorrhage (blood loss >1000 ml. A study involving 2000 women will have 80% power to detect a 36% relative change in the risk of major haemorrhage with two-sided 5% alpha. Discussion It is both important and timely that we evaluate the optimal approach to the management of the third stage at elective caesarean section. Safe operative delivery is now a priority and a reality for many pregnant women. Obstetricians, obstetric anaesthetists, midwives and pregnant women need high quality evidence on which to base management approaches. The overall aim is to reduce maternal haemorrhagic morbidity and its attendant risks at elective caesarean section. Trial registration number: ISRCTN17813715

Montgomery Alan A

2009-08-01

2

Study protocol. ECSSIT - Elective Caesarean Section Syntocinon Infusion Trial. A multi-centre randomised controlled trial of oxytocin (Syntocinon) 5 IU bolus and placebo infusion versus oxytocin 5 IU bolus and 40 IU infusion for the control of blood loss at elective caesarean section.  

LENUS (Irish Health Repository)

BACKGROUND: Caesarean section is one of the most commonly performed major operations in women throughout the world. Rates are escalating, with studies from the United States of America, the United Kingdom, China and the Republic of Ireland reporting rates between 20% and 25%. Operative morbidity includes haemorrhage, anaemia, blood transfusion and in severe cases, maternal death. The value of routine oxytocics in the third stage of vaginal birth has been well established and it has been assumed that these benefits apply to caesarean delivery as well. A slow bolus dose of oxytocin is recommended following delivery of the baby at caesarean section. Some clinicians use an additional infusion of oxytocin for a further period following the procedure. Intravenous oxytocin has a very short half-life (4-10 minutes) therefore the potential advantage of an oxytocin infusion is that it maintains uterine contractility throughout the surgical procedure and immediate postpartum period, when most primary haemorrhages occur. The few trials to date addressing the optimal approach to preventing haemorrhage at caesarean section have been under-powered to evaluate clinically important outcomes. There has been no trial to date comparing the use of an intravenous slow bolus of oxytocin versus an oxytocin bolus and infusion. METHODS AND DESIGN: A multi-centre randomised controlled trial is proposed. The study will take place in five large maternity units in Ireland with collaboration between academics and clinicians in the disciplines of obstetrics and anaesthetics. It will involve 2000 women undergoing elective caesarean section after 36 weeks gestation. The main outcome measure will be major haemorrhage (blood loss >1000 ml). A study involving 2000 women will have 80% power to detect a 36% relative change in the risk of major haemorrhage with two-sided 5% alpha. DISCUSSION: It is both important and timely that we evaluate the optimal approach to the management of the third stage at elective caesarean section. Safe operative delivery is now a priority and a reality for many pregnant women. Obstetricians, obstetric anaesthetists, midwives and pregnant women need high quality evidence on which to base management approaches. The overall aim is to reduce maternal haemorrhagic morbidity and its attendant risks at elective caesarean section. TRIAL REGISTRATION: number: ISRCTN17813715.

Murphy, Deirdre J

2009-01-01

3

Where does ergometrine stand in prevention of postpartum haemorrhage in caesarean section  

International Nuclear Information System (INIS)

Objective: To compare the safety and efficacy of 10 units of intravenous syntocinon alone with 10 units intravenous syntocinon and 0.25 mg intramuscular ergometrine in the prevention of atonic uterine haemorrhage during caesarean section. Method: The quasi-experimental study was conducted at the Maternal and Child Health Centre, Unit I, Pakistan Institute of Medical Sciences, Islamabad, from November 1, 2010 to February 28, 2011. All women undergoing caesarean section were included in the study. Patients were given intravenous 10 units syntocinon alone intra-operatively from November 1 to December 31, 2010, while 0.25 mg ergometrine intramuscular was added to 10 units intravenous syntocinon from January 1 to February 28, 2011. Frequency of postpartum haemorrhage, adverse effects of drugs and maternal morbidity and mortality were assessed by using chi square test. P <0.05 was taken as statistically significant. Results: Of the total number of 701 subjects, 378 (54%) women were given 10 units syntocinon and 323 (46%) were given 0.25 mg ergometrine in addition to 10 units syntocinon. The mean age in the syntocinon group was 28+-3.5 yrs with gestational age of 37.5+-2 weeks, while that in syntocinon-ergometrine group was 29+-3.4 years and 38+-2 weeks respectively. Postpartum haemorrhage in the syntocinon group was found in 38 (10%) women versus 05 (1.5%) women) in the other group (p<0.001). Adverse effects like nausea, vomiting and raised blood pressure were slightly more with syntocinon-ergometrine than syntocinon alone (n=56; 15.3% vs n=35; 9.2%), but it was not statistically significant. Post partum haemorrhage was responsible for 40% of maternal mortality during the study period and that was in the syntocinon group. Conclusion: Prophylactic ergometrine in addition to syntocinon is superior to syntocinon alone in decreasing frequency of postpartum haemorrhage in caesarean section and associated maternal morbidity and mortality. Regarding safety profile, the two groups showed no statistically significant change. (author)

4

Comparison of Ephedrine infusion and crystalloid preload in maintaining blood pressure in cesarean section under spinal anesthesia  

Directory of Open Access Journals (Sweden)

Full Text Available Hypotention is hazardous for fetus and mother under spinal anesthesia in cesarean section. Prophylactic effect of crystalloid preload and ephedrine infusion were compared in preventing of hypotention in these patients. From the cases, 44 women candidate for elective cesarean section were randomly divided in two groups. In first group, 15 ml per kg Ringer infused before spinal anesthesia. In the second group, Ephedrine infusion 0.25 mg/kg/3 min started immediately after spinal. During the section, BP was more stable in second group than the first group. Therefore ephedrine infusion seems to be more effective in controlling of BP in these patients.

Sadeghy Poor Roodsary H

2001-10-01

5

Comparison of Ephedrine infusion and crystalloid preload in maintaining blood pressure in cesarean section under spinal anesthesia  

OpenAIRE

Hypotention is hazardous for fetus and mother under spinal anesthesia in cesarean section. Prophylactic effect of crystalloid preload and ephedrine infusion were compared in preventing of hypotention in these patients. From the cases, 44 women candidate for elective cesarean section were randomly divided in two groups. In first group, 15 ml per kg Ringer infused before spinal anesthesia. In the second group, Ephedrine infusion 0.25 mg/kg/3 min started immediately after spinal. During the sect...

Sadeghy Poor Roodsary H; Maaref H; Eshraghian, MR

2001-01-01

6

A randomised controlled trial of oxytocin 5IU and placebo infusion versus oxytocin 5IU and 30IU infusion for the control of blood loss at elective caesarean section--pilot study. ISRCTN 40302163.  

LENUS (Irish Health Repository)

OBJECTIVE: To compare the blood loss at elective lower segment caesarean section with administration of oxytocin 5IU bolus versus oxytocin 5IU bolus and oxytocin 30IU infusion and to establish whether a large multi-centre trial is feasible. STUDY DESIGN: Women booked for an elective caesarean section were recruited to a pilot randomised controlled trial and randomised to either oxytocin 5IU bolus and placebo infusion or oxytocin 5IU bolus and oxytocin 30IU infusion. We wished to establish whether the study design was feasible and acceptable and to establish sample size estimates for a definitive multi-centre trial. The outcome measures were total estimated blood loss at caesarean section and in the immediate postpartum period and the need for an additional uterotonic agent. RESULTS: A total of 115 women were randomised and 110 were suitable for analysis (5 protocol violations). Despite strict exclusion criteria 84% of the target population were considered eligible for study participation and of those approached only 15% declined to participate and 11% delivered prior to the planned date. The total mean estimated blood loss was lower in the oxytocin infusion arm compared to placebo (567 ml versus 624 ml) and fewer women had a major haemorrhage (>1000 ml, 14% versus 17%) or required an additional uterotonic agent (5% versus 11%). A sample size of 1500 in each arm would be required to demonstrate a 3% absolute reduction in major haemorrhage (from baseline 10%) with >80% power. CONCLUSION: An additional oxytocin infusion at elective caesarean section may reduce blood loss and warrants evaluation in a large multi-centre trial.

Murphy, Deirdre J

2012-02-01

7

Case report: hyponatremia and generalized convulsion after intravenous oxytocin infusion  

Directory of Open Access Journals (Sweden)

Full Text Available Most patients with drug-induced hyponatraemia are asymptomatic and the diagnosis is made incidentally following routine blood tests. Mild cases may be managed either by stopping the drug or by careful observation if the drug is considered essential. Severe hyponatremia (serum sodium levels less than 120 mmol/l is associated with increased morbidity and mortality (confusion, convulsions, coma, congestive heart failure e.g.. We present a case of severe water intoxication with convulsion and prolonged coma, following the use of a high dose syntocinon infusion. A 22-year-old female who has intrauterine anencephalic fetus was refered to our hospital. Intravenous oxytocin was used to induce first-trimester abortion, eight hours later generalized tonic-clonic seizures occured and coma followed. Hyponatremia was found as the cause and treated by intravenous infusion of hypertonic 3% NaCl. The patient recovered and no seizure observed on follow-up. The central nervous system manifestations of acute hyponatremia may be related to cerebral edema. Drugs administration and electrolyte disturbances should be remembered as causes of coma and seizure in obstetric patients.

Ufuk Emre

2009-03-01

8

Induction of labor using double balloon cervical device in women with previous cesarean section: Experience and review  

Directory of Open Access Journals (Sweden)

Full Text Available Induction of labour remains one of the most challenging interventions in current obstetrics. Different pharmaceuticals have been used for cervical ripening such as prostaglandins; however they can lead to a number of potential inconvenient risks namely uterine tachysystole and pathological fetal cardiotocography (CTG. In cases of women with previous caesarean births, using prostaglandins would pose even higher risks such as uterine rupture and perinatal mortality. A mechanical method of cervical ripening could represent an alternative for these women. We report the use of the extra-amniotic double balloon cervical device (Cook’s device for ripening of unfavourable cervix in seventeen women attempting vaginal birth after cesarean section (VBAC. Using Bishop scoring system to assess cervical dilatetion, position, consistency, fetal station and effacement, the unfavourable cervix is the cervix that scores less than 6. We review the relevant literature discussing this method of induction focusing on its effectiveness, simplicity, safety and efficacy, low cost and any associated serious side effects. Conclusion: Success was estimated to be over 50% with no serious life threatening maternal or fetal complications. We considered the process satisfactory and practical. We recommend larger studies to assess safety and efficacy of Cook’s device in vaginal birth after caesarean section before embarking on routine elective caesarean delivery. Objectives: To estimate success rate for vaginal delivery after previous caesarean section using cervical double balloon device (Cook’s device. Design: Three-year observational study. Setting: Maternity unit in district general hospital, UK. Population: Women who had one previous lower segment caesarean section and unfavourable cervix identified as having Bishop Score less than 6. Methods: Data were obtained from the birth registry over 3 years from January 2008 until December 2010. Main outcome: Measure successful vaginal delivery. Results: Out of 25 cases that had induction of labour with history of one previous lower segment caesarean section, 17 patients did fit in the inclusion criteria and were studied. 53% had a successful vaginal delivery while 47% had to have cesarean section either due to failure to progress or pathological cardiotocography. 82% required to have syntocinon infusion for augmentation as per local unit protocol. All newborn babies were in good condition and did not require admission to neonatal intensive care unit.

N. Nassif

2013-03-01

9

Continuous-infusion adriamycin  

International Nuclear Information System (INIS)

This chapter discusses the diminished cardiotoxicity as well as diminished nausea and vomiting with continuous infusions of adriamycin to patients undergoing radiation therapy, particularly with infusions of 48 hours or longer, and best with 96-hour infusions, the longest duration that has been studied systematically. In breast cancer, data show that more adriamycin is better, but only for a selected subgroup of patients: those with complete remission. The diminished cardiotoxicity makes the use of adriamycin more attractive in the adjuvant situation, where increased safety will decrease the chances of long-term complications and make retreatment easy for cured patients who develop second malignancies

10

Saline infusion sonohysterography.  

Science.gov (United States)

Saline infusion sonohysterography consists of ultrasonographic imaging of the uterus and uterocervical cavity, using real-time ultrasonography during injection of sterile saline into the uterus. When properly performed, saline infusion sonohysterography can provide information about the uterus and endometrium. The most common indication for sonohysterography is abnormal uterine bleeding. sonohysterography should not be performed in a woman who is pregnant or could be pregnant or in a woman with a pelvic infection or unexplained pelvic tenderness. Physicians who perform or supervise diagnostic saline infusion sonohysterograpy should have training, experience, and demonstrated competence in gynecologic ultrasonography and saline infusion sonohysterography. Portions of this document were developed jointly with the American College of Radiology and the American Institute of Ultrasound in Medicine. PMID:14968760

2004-01-01

11

Infusion-embolization.  

Science.gov (United States)

Transcatheter intra-arterial therapy for the cancer patient encompasses infusion of chemotherapy and embolization. Intra-arterial infusion of chemotherapeutic agents has been resurrected because of the availability of new drugs, combinations of drugs, and the capability of percutaneous selective catheter placement. Intra-arterial infusion has been effective in patients with carcinomas of the liver, bladder, prostate, uterus, ovary, and lung and in bone and soft tissue sarcomas, melanomas, and tumors of the brain. Embolization of the arterial supply, creating ischemia of the neoplasm, has been employed in the therapeutic management of patients with primary and secondary neoplasms of the liver, kidney, and bone. The median survival of 100 patients with neoplasms of the liver from the time of hepatic artery embolization was 11.5 months. In 100 patients with pulmonary metastases from carcinoma of the kidney, 28 experienced a response to renal artery embolization, a therapeutic delay of 4 to 7 days, nephrectomy, and Depo-Provera (medroxyprogesterone). Seven of 12 patients with giant cell tumor of the pelvis and lumbar spine responded to arterial embolization after all other therapy failed. Chemoembolization, the combination of arterial infusion of chemotherapy and embolization, can be accomplished by the use of microencapsulated agents, liposomes, and particulate emboli with drugs. This approach integrates the advantages of infusion and occlusion, and has considerable potential. Intra-arterial immunotherapy has been initiated with bacillus Calmette-Guerin (BCG) administration into renal neoplasms in patients with metastatic disease. PMID:6093984

Wallace, S; Charnsangavej, C; Carrasco, C H; Bechtel, W

1984-12-01

12

Continuous radioisotope infusion  

International Nuclear Information System (INIS)

Continuous infusion of a radioactive marker was used instead of a conventional bolus injection to improve haemodynamic studies. Tc-99m was infused into the blood circulation at a constant rate for 100-300 seconds and the activity in the target structure was measured by a gamma camera with a computer system or by a single detector. The concentration of the marker increased linearly at the same rate throughout the circulating system. Due to variations in transport time from infusion site to different parts of the system the rise of activity occurred at different times. A theory for the calculations was presented and consequently confirmed in a model study. Blood flow patterns in artificial kidneys and alterations in renal blood flow induced by angiotensin were studied. The results are presented as time-function curves or as computer images. This technique can be used to evaluate distributions and alterations of flow in separate parts of a complex circulating system. (author)

13

21 CFR 526.1696b - Penicillin G procaine-dihydrostreptomycin in soybean oil for intramammary infusion (dry cows).  

Science.gov (United States)

...intramammary infusion (dry cows). 526.1696b Section...ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED...intramammary infusion (dry cows). (a) Specifications...calving. For use in dry cows only. Milk taken from cows...

2010-04-01

14

21 CFR 526.1696c - Penicillin G procaine-dihydrostreptomycin sulfate for intramammary infusion (dry cows).  

Science.gov (United States)

...intramammary infusion (dry cows). 526.1696c Section...ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED...intramammary infusion (dry cows). (a) Specifications...Not for use in lactating cows. Milk taken from...

2010-04-01

15

The use of a volumetric infusion pump for the intra-arterial infusion of drugs.  

OpenAIRE

Volumetric infusion pumps are widely used for intravenous infusions. We have extended their use to the intra-arterial infusion of drugs. An in vitro evaluation of the performance of such devices, under experimental conditions comparable to an intra-arterial infusion, was carried out. The results obtained confirmed the accuracy of volumetric infusion pumps for intra-arterial infusions. The system was found to be safe, reliable and simple in clinical practice.

Cooper, A. M.; Lilliman, M.

1985-01-01

16

Drugs given by intravenous infusion  

OpenAIRE

Nowadays for a large number of patients admitted to a hospital intravenous infusion of fluids is an important part of their treatment. These fluids serve as a correction of the fluid and/or electrolyte balance, as a carrier for drugs, as a substitute to oral nutrition or to compensate the loss of blood. Despite the fact, that many infusions are accompanied by a lot of problems, coherent and basical investigations into the origin of these problems have hardly been done. At the same time there ...

Steenhoek, Adrianus

1983-01-01

17

Clinical pharmacology of infusion fluids  

OpenAIRE

Fluids are used for intravenous infusion during practically all surgeries, but several different compositions are available on the market. Crystalloid fluids comprise lactated or acetated Ringer solutions, normal saline, Plasma-Lyte, hypertonic saline, and glucose. They lack allergic properties but are prone to cause peripheral tissue oedema. Their turn­ over is governed by physiological factors such as dehydration and drug effects. Colloid fluids include hydroxyethyl starch, albumin, dextra...

Hahn, Robert G.

2012-01-01

18

Continuous infusion with implantable pumps  

International Nuclear Information System (INIS)

This paper discusses a battery-powered, telemetry, programmable pump connected to a silicon catheter placed percutaneously through the subclavian or internal jugular vein that has been used to administer prolonged infusion of cytotoxic agents. The authors analyzed technique, system performance, and results for 246 consecutive systemic implants. The implantation procedures were performed entirely by the interventional radiology staff, and the encountered complications were diagnosed and controlled by using conventional radiography, digital subtraction angiography, and CT. It was concluded that management of totally implantable devices requires skilled organization and ready availability of radiologic equipment

19

A Model for Infusing Energy Concepts into Vocational Education Programs. Solar Energy Curriculum Guide.  

Science.gov (United States)

This solar energy curriculum guide is designed to assist teachers in infusing energy concepts into vocational education programs. It consists of 31 competency-based instructional units organized into 10 sections. Covered in the sections are the following topics: related instructions (history and development; human relations; general safety;…

Delta Vocational Technical School, Marked Tree, AR.

20

Grass-green urine from propofol infusion.  

Science.gov (United States)

Green urine from propofol infusion is a benign and rare side effect. The discolouration appears when clearance of propofol exceeds hepatic elimination, and extrahepatic elimination of propofol occurs. This case report presents a 24-year-old male with grass green discolouration of urine based on propofol infusion. PMID:25394533

Pedersen, A B; Kobborg, T K; Larsen, J R

2015-02-01

21

Air elimination capability in rapid infusion systems.  

Science.gov (United States)

Pressure infusion devices are used in clinical practice to apply large volumes of fluid over a short period of time. Although air infusion is a major complication, they have limited capability to detect and remove air during pressure infusion. In this investigation, we tested the air elimination capabilities of the Fluido(®) (The Surgical Company), Level 1(®) (Level 1 Technologies Inc.) and Ranger(®) (Augustine Medical GmbH) pressure infusion devices. Measurements were undertaken with a crystalloid solution during an infusion flow of 100, 200, 400 and 800 ml.min(-1). Four different volumes of air (25, 50, 100 and 200 ml) were injected as boluses in one experimental setting, or infused continuously over the time needed to perfuse 2 l saline in the other setting. The perfusion fluid was collected in an airtight infusion bag and the amount of air obtained in the bag was measured. The delivered air volume was negligible and would not cause any significant air embolism in all experiments. In our experimental setting, we found, during high flow, an increased amount of uneliminated air in all used devices compared with lower perfusion flows. All tested devices had a good air elimination capability. The use of ultrasonic air detection coupled with an automatic shutoff is a significant safety improvement and can reliably prevent accidental air embolism at rapid flows. PMID:22004201

Zoremba, N; Gruenewald, C; Zoremba, M; Rossaint, R; Schaelte, G

2011-11-01

22

Krypton 81m infusion studies. Chapter 18  

International Nuclear Information System (INIS)

A technique is described to give a continuous, constant-rate, intravascular infusion of 81Krsup(m). Modifications of earlier generators included production of sodium-free 81Rb, the use of a solution of commercial sterile isotonic non-ionic 5% dextrose-in-water as an eluant, the incorporation of a constant-rate infusion pump, and the miniaturization of the generator column and catheter system. Results are presented of studies of 81Krsup(m) distribution in dogs, using both intravenous and intra-arterial infusion. (author)

23

A new infusion pathway intactness monitoring system.  

Science.gov (United States)

A new infusion pathway monitoring system has been developed for hospital and home use. The system consists of linear integrated circuits and a low-power 8-bit single chip microcomputer which constantly monitors the infusion pathway intactness. An AC (alternating current) voltage is induced on the patient's body by electrostatic coupling from the normal 100 volt, 60 Hz AC power line wiring field in the patient's room. The induced AC voltage can be recorded by a main electrode wrapped around the infusion polyvinyl chloride tube. A reference electrode is wrapped on the electrode to monitor the AC voltage around the main electrode. If the injection needle or infusion tube becomes detached, then the system detects changes in the induced AC voltages and alerts the nursing station, via the nurse call system or PHS (personal handy phone system). PMID:17945872

Ogawa, Hidekuni; Yonezawa, Yoshiharu; Maki, Hiromichi; Ninomiya, Ishio; Sata, Koji; Hamada, Shingo; Caldwell, W Morton

2006-01-01

24

[Pharmacokinetics of cephapirin sodium during intravenous infusion].  

Science.gov (United States)

Studies on absorption and excretion of cephapirin (CEPR) are described. CEPR was administered by intravenous drip infusion to 4 healthy volunteers weighing 53 kg to 61 kg, and the serum levels were measured. Pharmacokinetic parameters were calculated by one-compartment model and two-compartment model. Each model was comparatively applied to every founds. Most appropriate administration rate of intravenous drip infusion was discussed due to calculated serum levels, therapeutic AUC and effective time. PMID:6655830

Imoto, T

1983-08-01

25

Immunoglobulin replacement treatment by rapid subcutaneous infusion  

OpenAIRE

Long term intravenous immunoglobulin (IVIG) infusion is an effective treatment for children with immunodeficiencies, but can be complicated by poor venous access, systemic adverse reactions, and the need for frequent hospital admission. Rapid subcutaneous immunoglobulin (SCIG) infusion has been found to be effective in adults with primary immunodeficiency. Twenty six children were treated with SCIG for a median period of two years (range six months to 3.5 years). Fifteen ...

Gaspar, J.; Gerritsen, B.; Jones, A.

1998-01-01

26

Stability and Antibacterial Activity of Cefepime during Continuous Infusion  

OpenAIRE

The stability of cefepime during simulated continuous infusion was determined with a motorized portable infusion pump worn over a period of 24 to 36 h. Susceptibility testing on cefepime solutions over time indicates that the degradation products do not exhibit antibacterial activity. Cefepime stability at 24 h following continuous infusion was 94.3% ± 1.0%, which supports the use of continuous infusion.

Sprauten, Pa?l F.; Beringer, Paul M.; Louie, Stan G.; Synold, Timothy W.; Gill, Mark A.

2003-01-01

27

Subcutaneous insulin infusion: change in basal infusion rate has no immediate effect on insulin absorption rate  

International Nuclear Information System (INIS)

Eight insulin-dependent diabetic patients were simultaneously given subcutaneous infusions (1.12 IU/h each) of 125I-labeled Actrapid insulin in each side of the abdominal wall. After 24 h of infusion, the size of the infused insulin depots was measured by external counting for 5 h. The basal infusion rate was then doubled in one side and halved in the other for the next 4 h. Finally, 1.12 IU/h of insulin was given in both sides of the abdominal wall for an additional 3 h. The changes in the size of the depots were measured, and the absorption rates for each hour were calculated. During the first 5 h of infusion, the depot size was almost constant (approximately 5 IU) with an absorption rate that equaled the infusion rate. Doubling the infusion rate led to a significant increase in depot size, but the absorption rate remained unchanged for the first 3 h, and only thereafter was a significant increase seen. When the infusion rate was reduced to the initial 1.12 IU/h, the absorption rate remained elevated during the next 3 h. Correspondingly, when the infusion rate was decreased, the depot size also decreased, but the absorption rate remained unchanged for the first 3 h. The results show that a change in the basal insulin infusion rate does not lead to any immediate change in the insulin absorption rate. This should be considered when planning an insulin-infusion program that includes alteration(s) in the basal-rate settingtting

28

Vocal fold submucosal infusion technique in phonomicrosurgery.  

Science.gov (United States)

Phonomicrosurgery is optimized by maximally preserving the vocal fold's layered microstructure (laminae propriae). The technique of submucosal infusion of saline and epinephrine into the superficial lamina propria (SLP) was examined to delineate how, when, and why it was helpful toward this surgical goal. A retrospective review revealed that the submucosal infusion technique was used to enhance the surgery in 75 of 152 vocal fold procedures that were performed over the last 2 years. The vocal fold epithelium was noted to be adherent to the vocal ligament in 29 of the 75 cases: 19 from previous surgical scarring, 4 from cancer, 3 from sulcus vocalis, 2 from chronic hemorrhage, and 1 from radiotherapy. The submucosal infusion technique was most helpful when the vocal fold epithelium required resection and/or when extensive dissection in the SLP was necessary. The infusion enhanced the surgery by vasoconstriction of the microvasculature in the SLP, which improved visualization during cold-instrument tangential dissection. Improved visualization facilitated maximal preservation of the SLP, which is necessary for optimal pliability of the overlying epithelium. The infusion also improved the placement of incisions at the perimeter of benign, premalignant, and malignant lesions, and thereby helped preserve epithelium uninvolved by the disorder. PMID:8651626

Kass, E S; Hillman, R E; Zeitels, S M

1996-05-01

29

A new venous infusion pathway monitoring system.  

Science.gov (United States)

A new infusion catheter pathway monitoring system employing linear integrated circuits and a low-power 8-bit single chip microcomputer has been developed for hospital and home use. The sensor consists of coaxial three-layer conductive tapes wrapped around the polyvinyl chloride infusion tube. The inner tape is the main electrode, which records an AC (alternating current) voltage induced on the patient's body by electrostatic coupling from the normal 100 volt, 60 Hz AC power line wiring field in the patient's room. The outside tape layer is a reference electrode to monitor the AC voltage around the main electrode. The center tape layer is connected to system ground and functions as a shield. The microcomputer calculates the ratio of the induced AC voltages recorded by the main and reference electrodes and if the ratio indicates a detached infusion, alerts the nursing station, via the nurse call system or low transmitting power mobile phone. PMID:18002453

Maki, Hiromichi; Yonezawa, Yoshiharu; Ogawa, Hidekuni; Ninomiya, Ishio; Sata, Koji; Hamada, Shingo; Caldwell, W Morton

2007-01-01

30

[Intraarterial DDP and angiotensin II infusion chemotherapy].  

Science.gov (United States)

Twenty-four patients, each with advanced bladder cancer (BC) or brain tumor (BT), were treated by intraarterial infusion of angiotensin II in combination with DDP as the main drug together with other anticancer drugs. As for the frequency of treatment by the intraarterial therapy, only one course was given in 15 cases, two courses in 9 (BC), one course in 21 cases, and two courses in 3 (BT). CR was obtained in ten of 24 evaluable patients with BC and PR in eleven. Of 20 evaluable patients with BT, 3CRs and 7PRs were attained. The selective enhancement of tumoral blood flow induced by regionally infused angiotensin II was observed using continuous intraarterial infusion of krypton-81 m. PMID:3015032

Mitsuhata, N; Matsumura, Y

1986-04-01

31

Regional antibiotic infusion of the heart.  

Science.gov (United States)

Regional arterial infusion of the heart and lung with an antibiotic did not increase the drug in the aortic serum to concentrations that would be clinically significant when compared with concentrations which can be attained by the intravenous method in a near normal functioning heart. PMID:1257869

Waterman, N G; Temes, G D; Scharfenberger, L

1976-04-01

32

Infusing International Experience into the Curriculum.  

Science.gov (United States)

In an effort to increase students' global awareness, New Jersey's Raritan Valley Community College (RVCC) has developed a number of courses and programs designed to infuse an international and intercultural perspective into the curriculum. Among the on-going projects of the college are: (1) the integration of a basic composition and an…

Salas, Dominador J.

33

Rapid Self-infusion of Tap Water  

Directory of Open Access Journals (Sweden)

Full Text Available Intravenous self-infusion of tap water has never been reported in the literature.  We present a 24-year-old healthy man who self-administered 2.5 L of tap water over 2 hours and developed acute illness including fever, change of mental status, acute hemolysis, low-grade disseminated intravascular coagulation, and acute kidney injury.  

Sanjay Chaudhary

2013-03-01

34

Infusing interprofessional education into the nursing curriculum.  

Science.gov (United States)

Education for interprofessional collaboration should begin early in the nursing program with a gradual infusion of interprofessional competencies into the curriculum. The faculty developed an interprofessional education program for students in nursing, physical therapy, nutrition, and respiratory care, which focused on sharing knowledge about each discipline, developing respect and value for each other's disciplines, and emphasizing techniques to improve communication and teamwork. PMID:25154006

Cranford, Joan Sistrunk; Bates, Teresa

2015-01-01

35

21 CFR 526.88 - Amoxicillin trihydrate for intramammary infusion.  

Science.gov (United States)

...2010-04-01 2010-04-01 false Amoxicillin trihydrate for intramammary infusion...INTRAMAMMARY DOSAGE FORMS § 526.88 Amoxicillin trihydrate for intramammary infusion... Each single dose syringe contains amoxicillin trihydrate equivalent to 62.5...

2010-04-01

36

Pharmacokinetics of continuous subcutaneous insulin infusion  

DEFF Research Database (Denmark)

One of the reasons for the variability of blood glucose regulation in Type 1 (insulin-dependent) diabetic patients is the huge variation in subcutaneous absorption of intermediate-acting insulin. We have investigated the variation in insulin absorption during continuous subcutaneous insulin infusion in eight such patients. The content of insulin in the subcutaneous tissue was measured using 125I-labelled insulin. The concentration of free serum insulin and blood glucose was followed from 1 h before and from 7 h after breakfast on two consecutive days. The amount of insulin absorbed during 24 h differed in all cases by less than 3% from the daily insulin dose given by the pumps. Mean insulin absorption rates and mean free insulin concentration showed peak values 30-90 min after meal bolus injections; this was sufficient to maintain near-normal blood glucose. Mean free serum insulin correlated strongly with disappearance of insulin from the subcutaneous tissue (r = 0.98). From the insulin absorption rates and free insulin concentrations during basal constant insulin infusion, the half-time of serum insulin was calculated as 6 min. Compared with the known large variability in the absorption of intermediate-acting insulin, continuous subcutaneous insulin infusion offers a precise and reproducible way of insulin administration resulting in post-prandial serum insulin peaks sufficient to maintain near-normal blood glucose levels. The half-time of serum insulin during subcutaneous infusion corresponds to values for intravenous infusion given in the literature, indicating that local degradation of insulin in subcutaneous tissue is of minor importance.

Lauritzen, Torsten; Pramming, S

1983-01-01

37

Body distribution of infused serotonin in rats.  

Science.gov (United States)

1. Our goal was to investigate the body distribution of serotonin (5-hydroxytryptamine; 5-HT) in rats infused with 5-HT (25 microg/kg per min) for 7 days and the contribution of the 5-HT transporter (SERT) for 5-HT uptake into the tissues. 2. Mini-osmotic pumps containing 5-HT or vehicle were implanted in rats knocked out for SERT (SERT-KO) or in wild-type (WT) rats. On the 8th day, tissues were harvested for measurements of 5-HT by high-performance liquid chromatography (HPLC). The 5-HT metabolite 5-hydroxyindole acetic acid (5-HIAA) was also measured by HPLC, because an increase in 5-HIAA in tissues from rats receiving 5-HT reflects 5-HT uptake followed by metabolism. 3. In WT rats infused with 5-HT, an increase in 5-HT or 5-HIAA was observed in the heart, pancreas, thyroid, adrenal gland, kidney, seminal vesicle, bladder, prostate, liver, oesophagus, stomach, femur, trachea, lung and spleen compared with vehicle-infused rats. An increase in 5-HT and 5-HIAA was not observed in aorta, vena cava and jejunum. In tissues from SERT-KO rats infused with 5-HT, the content of 5-HT or 5-HIAA was decreased in most of the tissues studied compared with 5-HT-infused WT rats. Although 5-HT uptake in the kidney, seminal vesicle, prostate, jejunum and trachea is SERT dependent, it is SERT independent in the pancreas. The remaining tissues display SERT-dependent and -independent mechanisms for 5-HT uptake. 4. Altogether, tissues from different systems, such as the cardiovascular, endocrine, genitourinary and gastrointestinal, accumulate 5-HT mainly via SERT and, thus, these systems are potential targets for drugs that interfere with 5-HT homeostasis. PMID:19207716

Linder, A Elizabeth; Beggs, Kevin M; Burnett, Robert J; Watts, Stephanie W

2009-05-01

38

Numerical Simulation Study on the Coal Seam Pulse Water Infusion  

Directory of Open Access Journals (Sweden)

Full Text Available In the process of coal seam pulse water infusion, liquid-solid coupling effect exists in coal seam between the stress field and seepage field. Based on the basic principle of liquid-solid coupling, the dynamic liquid-solid coupling effect of stress and seepage field during coal seam pulse water infusion is simulated through secondary development of ABAQUS software, during this process the mathematical model of the strain accumulation model due to the periodic changes of pulse water pressure is embedded in SOIL module of ABAQUS software. The law of different parameters of pulse water infusion on the permeability of coal around the infusion hole is gotten. Numerical simulation results show that, during the process of coal seam high pressure pulse water infusion, the stress field and flow field are mutual influence and mutual restriction. The coupling of the stress and flow field have impact on the physical and mechanical properties of coal in front of the working face, these factors promote each other and preventing coal and gas outburst effectively. The permeability of coal increase significantly with the water infusion time prolong under constant water infusion pressure and frequency. The permeability of coal increase significantly with the water infusion pressure improving under constant water infusion time and frequency. The permeability of coal increase significantly with the water infusion frequency improving under constant water infusion pressure and time. So the pulse water infusion time needs to ensure a better effect of preventing coal and gas outburst is gotten. Meanwhile the high pressure pulse water infusion pressure needs to improve under the existing technical conditions and not cause big coal fissure. The frequency of pulse water infusion needs to improve under the existing technical conditions. This research results have great theoretical value and practical significance on revealing the mechanism of coal seam pulse water infusion on permeability, enhancing the validity of the technological parameters design in coal seam water infusion and implementing the technology in the site.

Meng Junqing

2014-01-01

39

Brain activity following esophageal acid infusion using positron emission tomography  

OpenAIRE

AIM: To investigate symptoms and brain activity following esophageal acid infusion.METHODS: Fifteen healthy volunteers were recruited for the study. Hydrochloric acid (pH 1 and 2) and distilled water (pH 7) were randomly and repeatedly infused into the esophagus. The brain activity was evaluated by positron emission tomography. The severity of heartburn elicited by the infusion was rated on an auditory analog scale of 0-10.RESULTS: The severity of heartburn following each infusion showed a st...

Shigeyuki Kobayashi, Yasuhiko Abe

2010-01-01

40

Development of individual insulin infusion profiles for open loop infusion systems  

OpenAIRE

The computer program for the open loop infusion device simulated the feed-back structure of a closed loop insulin secretion control by an algorithm based upon a theoretical postprandial blood sugar profile. Fifteen unstable juvenile onset insulin requiring diabetics could be well controlled after two to three days of an intravenous open loop insulin infusion program. The programs consisted of two constant basal rates and superimposed wavy step profile programs activated at the beginning of ea...

Strack, Thomas; Krause, Ulrich; Schulz, Gerhard; Beyer, Ju?rgen; Beutelspacher, Friedrich; Nagel, Joachim H.

1984-01-01

41

[Levodopa intestinal infusion therapy in Parkinson's disease].  

Science.gov (United States)

Medical treatment of advanced Parkinson disease complicated with fluctuations and dyskinesias remains difficult or in some patients totally ineffective. Recently, new methods were introduced to manage those problems: deep brain stimulation, subcutaneous apomorphine infusion and the Duodopa system for intrajejunal continuous delivery of gel containing levo-dopa/carbidopa (through percutaneous gastrostomy). This last method was proven to be very effective in reducing the fluctuations of levodopa plasma levels and furthermore in reducing the off periods and dyskinesias. The Duodopa system is used in patients with contraindications to deep brain stimulation or apomorphine infusions. According to recently published studies, it may also be more effective in reducing motor complications than other methods. The authors present the current knowledge on the Duodopa system, its effectiveness (also in relationship to other methods, specially deep brain stimulation and apomorphine) and possible complications (mostly due to gastric tube failures) along with the indications and contraindications. PMID:20827613

S?awek, Jaros?aw; Bogucki, Andrzej

2010-01-01

42

Epipodophyllotoxin and cisplatin on continuous infusion schedules  

International Nuclear Information System (INIS)

The Epipodophyllotoxins, VP16-213 and VM26, and the heavy metal cytotoxic agents, Cisplatin and its analogs, Spriogermanium and Gallium are discussed as representing classes of agents which in clinical trials are traditionally delivered on an intermittent bolus schedule to coincide with radiation therapy. The continuous infusion of VP16-213 has a strong rationale based upon pharmacokinetic considerations of the drug and schedule dependency in experimental tumor systems. The regional delivery of Cisplatin is examined and has demonstrated some exceptional therapeutic effects, particularly in brain tumors, although toxicity has been substantial. VP16-213 has practical limitations with regard to the infusion schedule relative to the insolubility of the agent in small volumes

43

Software Engineering Technology Infusion Within NASA  

Science.gov (United States)

Abstract technology transfer is of crucial concern to both government and industry today. In this paper, several software engineering technologies used within NASA are studied, and the mechanisms, schedules, and efforts at transferring these technologies are investigated. The goals of this study are: 1) to understand the difference between technology transfer (the adoption of a new method by large segments of an industry) as an industry-wide phenomenon and the adoption of a new technology by an individual organization (called technology infusion); and 2) to see if software engineering technology transfer differs from other engineering disciplines. While there is great interest today in developing technology transfer models for industry, it is the technology infusion process that actually causes changes in the current state of the practice.

Zelkowitz, Marvin V.

1996-01-01

44

Superselective arterial infusion and concomitant radiotherapy  

Energy Technology Data Exchange (ETDEWEB)

Superselective arterial infusion for patients with advanced head and neck cancer has been increasingly applied in Japan. We analyzed our experiences and evaluated the efficacy and safety of this treatment. Through October 1999 to March 2002, 29 patients, ranging in age between 33 and 71 years (median 52 years), received superselective intra-arterial infusion therapy of cisplatin (100-120 mg/m{sup 2}/week) with simultaneous intravenous infusion of thiosulfate for neutralizing cisplatin toxicity, and conventional concomitant extrabeam radiotherapy (65 Gy/26 f/6.5 weeks). Four patients were diagnosed with stage III and 25 with stage IV. Thirteen patients were considered contraindicated for surgery, and the other 16 patients rejected radical surgery. Primary tumor sites included paranasal sinus (11 patients), hypopharynx (7), oropharynx (6), oral cavity (4), and parotid gland (1). During the median follow-up period of 20 months, there was no apparent recurrence in 14 (48.3%) of 29 patients. Eleven (37.9%) patients died of disease, and three (10.3%) were alive with disease. In twenty-one patients (72.4%) the primary lesions were well-controlled. Acute toxic effects were moderate, and severe toxic events occurred in four cases, namely, methicillin-resistant staphylococcus aureus (MRSA) pneumonia, sepsis, tetraplasia, and osteoradionecrosis. We confirmed the effectiveness and safety of superselective arterial infusion and concomitant radiotherapy. Furthermore, we must establish the optimal procedures and schedule, as well as the indications for this treatment. This treatment protocol may improve the prognosis of patients with unresectable disease and patients rejecting surgical treatment. Further study in this particular area is needed. (author)

Homma, Akihiro; Suzuki, Fumiyuki; Inuyama, Yukio; Fukuda, Satoshi [Hokkaido Univ., Sapporo (Japan). School of Medicine

2003-05-01

45

Superselective arterial infusion and concomitant radiotherapy  

International Nuclear Information System (INIS)

Superselective arterial infusion for patients with advanced head and neck cancer has been increasingly applied in Japan. We analyzed our experiences and evaluated the efficacy and safety of this treatment. Through October 1999 to March 2002, 29 patients, ranging in age between 33 and 71 years (median 52 years), received superselective intra-arterial infusion therapy of cisplatin (100-120 mg/m2/week) with simultaneous intravenous infusion of thiosulfate for neutralizing cisplatin toxicity, and conventional concomitant extrabeam radiotherapy (65 Gy/26 f/6.5 weeks). Four patients were diagnosed with stage III and 25 with stage IV. Thirteen patients were considered contraindicated for surgery, and the other 16 patients rejected radical surgery. Primary tumor sites included paranasal sinus (11 patients), hypopharynx (7), oropharynx (6), oral cavity (4), and parotid gland (1). During the median follow-up period of 20 months, there was no apparent recurrence in 14 (48.3%) of 29 patients. Eleven (37.9%) patients died of disease, and three (10.3%) were alive with disease. In twenty-one patients (72.4%) the primary lesions were well-controlled. Acute toxic effects were moderate, and severe toxic events occurred in four cases, namely, methicillin-resistant staphylococcus aureus (MRSA) pneumonia, sepsis, tetraplasia, and osteoradionecrosis. We confirmed the effectiveness and safety of superselective arterial infusion and concomitant radiotherapy. Furthermore, we must eitant radiotherapy. Furthermore, we must establish the optimal procedures and schedule, as well as the indications for this treatment. This treatment protocol may improve the prognosis of patients with unresectable disease and patients rejecting surgical treatment. Further study in this particular area is needed. (author)

46

Analysis of the vacuum infusion moulding process  

OpenAIRE

This thesis focuses on flow through compliant porous media with applications to the manufacturing of composites by vacuum infusion (VI). The context of this work is the need for reliability in environmentally friendly composite processing methods for composite materials. Commercial reality and the prospective application to low cost structures for the transportation industry dictate that appropriate emphasis should be put on obtaining robust simulations, ensuring reliability and progressing t...

Correia, Nuno Andre? Curado Mateus

2004-01-01

47

Continuous ampicillin infusion as an alternative to intermittent infusion for adult inpatients: a case series.  

Science.gov (United States)

Intravenous ampicillin has been extensively used for various kinds of infections for more than fifty years. This drug is administered intermittently, which can result in missed or delayed drug administration and sleep interruption that can have a negative impact on the quality of life during hospitalization. Continuous infusion may solve these concerns. We reviewed the cases of five patients who were treated with continuous ampicillin infusions in our hospital. The ampicillin serum concentrations were from 11.3 to 32.8 ?g/mL, which was above the ampicillin MICs of the causative organisms, ?0.06 to 4 ?g/mL. Although the dosages given of ampicillin varied in each case, the serum concentrations showed a strong correlation with creatinine clearance (r(2) = 0.91). All the patients improved at the time of discharge, or transfer to another hospital, with no significant complications during the continuous infusion. Continuous ampicillin infusion could be a better alternative for frequent intermittent infusion for adult inpatients with infections due to ampicillin-susceptible organisms. PMID:24972584

Ogawa, Taku; Kasahara, Kei; Ikawa, Kazuro; Shigeta, Junichi; Komatsu, Yuko; Kuruno, Noriko; Uno, Kenji; Maeda, Koichi; Mikasa, Keiichi

2014-10-01

48

Evaluation of Talbot's Safety Zone of Infusion Volume and Osmolality in Infusion Therapy for Decompensated Liver Cirrhosis  

Directory of Open Access Journals (Sweden)

Full Text Available Problems with infusion therapy for correcting fluid and sodium imbalance in decompensated liver cirrhosis (DLC were investigated by establishing the safety zone of Talbot et al. for parenteral fluid therapy in 4 DLC patients infused with over 900 ml of fluid each day for at least 9 days. The safety zone was different in each case. The safe infusion volume decreased and the safe electrolyte concentration shifted to a lower osmolality when there was ascites with renal failure than ascites without renal failure. Infusion therapy was performed without deterioration of the water and sodium balance in those patients whose infusion volume and fluid osmolality were in the safety zone. In contrast, ascites retention increased and peripheral edema appeared in patients whose infusion volume and osmolality were out of the safety zone. Therefore, the safety zone should be determined repeatedly during infusion therapy.

Yuasa,Shiro

1985-06-01

49

Intraarterial infusion chemotherapy for head and neck cancer using a totally implantable infusion pump.  

Science.gov (United States)

Intraarterial infusion chemotherapy has not been widely accepted for the treatment of head and neck cancer due to the high rate of complications it involves. To avoid these complications, a totally implantable infusion pump has been developed to achieve continuous low-level drug delivery for long periods of time. The pump is implanted in a subcutaneous pocket and connected to a permanent, indwelling, arterial catheter. It can be repeatedly refilled with chemotherapeutic agents by hypodermic needle injection through the skin and through a self-sealing septum located at the entry to the pump. Refilling the pump recharges an inexhaustible power source for the next delivery cycle. Preliminary results suggest that long term intraarterial infusion chemotherapy for the treatment of head and neck cancer is practical for outpatients. PMID:6458583

Baker, S R; Wheeler, R H; Ensminger, W D; Niederhuber, J E

1981-01-01

50

Management of severe hyponatremia: infusion of hypertonic saline and desmopressin or infusion of vasopressin inhibitors?  

Science.gov (United States)

Rapid correction of severe hyponatremia carries the risk of osmotic demyelination. Two recently introduced methods of correction of hyponatremia have diametrically opposite effects on aquaresis. Inhibitors of vasopressin V2 receptor (vaptans) lead to the production of dilute urine, whereas infusion of desmopressin causes urinary concentration. Identification of the category of hyponatremia that will benefit from one or the other treatment is critical. In general, vaptans are effective in hyponatremias presenting with concentrated urine and, with the exception of hypovolemic hyponatremia, can be used as their primary treatment. Desmopressin is effective in hyponatremias presenting with dilute urine or developing urinary dilution after saline infusion. In this setting, desmopressin infusion helps prevent overcorrection of the hyponatremia. Monitoring of the changes in serum sodium concentration as a guide to treatment changes is imperative regardless of the initial treatment of severe hyponatremia. PMID:25247759

Tzamaloukas, Antonios H; Shapiro, Joseph I; Raj, Dominic S; Murata, Glen H; Glew, Robert H; Malhotra, Deepak

2014-11-01

51

Immediate infusion-related adverse reactions to intravenous immunoglobulin in a prospective cohort of 1765 infusions.  

Science.gov (United States)

Intravenous immunoglobulin (IVIG) is increasingly recommended for many diseases apart from primary immunodeficiency diseases (PID). Although effective and safe, adverse reactions may occur. We conducted a 2-year prospective observational study in 117 patients with PID who received regular IVIG replacement therapy at a median dose of 600mg/kg every 3 to 4weeks to examine IVIG's adverse effects; 1765 infusions were performed (mean=15/patient) in 75 males and 42 females (aged 3months to 77years) in 3 groups: ?9years (34.2%), 10-19years (26.5%), and ?20years (39.3%). Fifty patients had common variable immunodeficiency (CVID), 11 had X-linked agammaglobulinemia (XLA), and 55 had other immune system disorders. The drugs administered were Octagam® (49.1%), Tegeline® (17.3%), Imunoglobulin® (18.6%), Flebogama® (12.9%), Vigam® (1.2%), and Kiovig® (0.4%). Immediate infusion-related adverse reactions occurred in the cases of 38 out 1765 infusions (2.15%, IC95% 1.53%-2.94%), which were classified as mild (81.6%), moderate (10.5%), or severe (7.9%). Time until reaction ranged from 10 to 240min (mean=85.7, median=60). Reaction rates were similar across age groups. The most common reactions were malaise, headache, and abdominal pain. Reported severe events were tightness of the throat and seizure. All symptoms improved with temporary or complete IVIG interruption and symptomatic medications. Sixteen of 38 reactions to infusions occurred in the presence of an acute infection (p=0.09). Tegeline® represented a greater reaction risk factor than Octagam® (p<0.001). These results indicate that IVIG infusion can be considered a safe procedure. Low reaction incidence and few severe immediate infusion-related adverse reactions were observed. PMID:25257732

Bichuetti-Silva, Danielli C; Furlan, Fernanda P; Nobre, Fernanda A; Pereira, Camila T M; Gonçalves, Tessa R T; Gouveia-Pereira, Mariana; Rota, Rafael; Tavares, Lusinete; Mazzucchelli, Juliana T L; Costa-Carvalho, Beatriz T

2014-12-01

52

Light protection of chemotherapy drugs for infusion.  

Science.gov (United States)

Specific chemotherapy drugs which require to be delivered by continuous infusion over time can have their effectiveness impaired by exposure to optical radiation. Mechanisms and processes of drug preparation and patient administration associated with light sensitive drugs were monitored within a Chemotherapy Unit. Levels of ambient light at locations of drug preparation/administration and levels of protection afforded by optical filter elements such as infusion lines were determined using a double grating Bentham Dmc150 spectroradiometer. Models of light exposure were developed for separate components of drug preparation and infusion delivery systems where the latter included the fluid bag with protective light cover, drip chamber and giving set line. In addition, the attenuation coefficient of Dacarbazine at the concentration typically used in patient treatments was determined using specially manufactured measurement cells. The relative contributions to light absorption of the drug bag, drip chamber and patient line were identified for specific types of giving sets, spectral content/intensity of light exposure and specific drug light absorption profiles. This indicated significant differences in the level of light protection afforded by specific giving sets and either single or double layer protection of the drug bag reservoir. It is not clear, however, if these variations could lead to significant differences of levels of drug de-activation and/or creation of undesirable photo-products such as in the case of Dacarbazine. Such techniques, however, provide a means of identifying how light exposure can be maintained at levels as low as reasonably possible as a precautionary measure. PMID:25556147

Clarkson, Douglas McG; Harvey, Roger; Sheepy, Dave

2015-02-01

53

[Neurological symptoms following infusion of infliximab].  

Science.gov (United States)

Infliximab is indicated for treatment of plaque psoriasis when traditional systemic therapy is inadequate or inappropriate. The treatment is efficient but also carries a risk of serious adverse drug events. We describe a case of neurological symptoms following the first infusion of infliximab in a patient treated for plaque psoriasis. The patient fully recovered after sensation of the therapy. We believe the symptoms could be related to infliximab and stress the importance of thorough information of patients treated with tumour necrosis factor-?-inhibitors, also about the risk of serious adverse events. PMID:23031302

Bebe, Anna C K M; Harboe, Kirstine Moll; Nøjgaard, Camilla

2012-10-01

54

Red Man Syndrome Adverse Reaction following Intravenous Infusion of Cefepime  

OpenAIRE

We report the first case of cefepime-induced “red-man syndrome,” which appeared 30 min following drug infusion and was confirmed with a rechallenge test. This syndrome is classically associated with vancomycin infusion and is the result of non-IgE mediated mast cell degranulation. While this adverse effect can be easily managed with drug withdrawal and antihistamine administration, it is unknown whether it can be prevented with slower cefepime infusion and preinfusion antihistamines, as i...

Panos, George; Watson, Dionysios C.; Sargianou, Maria; Kampiotis, Dionysios; Chra, Paraskevi

2012-01-01

55

INTRAVENOUS FENTANYL INFUSION AS AN ANALAGESIC AGENTS FOR LABOR PAIN  

OpenAIRE

Introduction. There are few studies about intravenous fentanyl infusion for reduce labor pain. This study evaluate the usefulness of intravenous fentanyl infusion for labor analgesia. Methods. Seventy seven healthy pregnant women were randomized to recive 1.5-2.5µg/kg/hr intravenous fentanyl infusion (interventional group) or placebo (control group). Maternal labor pain intensity, systolic, diastolic and mean arterial blood pressure, pulse and respiratory rate, frequency of nausea and v...

Soltani Nezhad, H.; SH ARAM; Monajjemi, Z.; Jaafar-zadeh, L.

2001-01-01

56

Investigations about new infusion pumps for medical applications  

OpenAIRE

In medical infusion technology there is a wide range of applications with each of them putting specific demands on the infusion pump, such as accuracy and range of delivery rates. While for parenteral feeding high delivery rates with lower demands on accuracy are needed, very low delivery rates and high demands on accuracy are required in intensive-care medicine. There are different types of pump systems in use to cover the whole range of applications in infusion therapy. Currently there is n...

Wolter, Frank

2013-01-01

57

Green Urine Discoloration due to Propofol Infusion: A Case Report  

OpenAIRE

We present a 19-year-old man who excreted green urine after propofol infusion. The patient was admitted to our hospital for injuries sustained in a traffic accident and underwent surgery. After starting continuous infusion of propofol for postoperative sedation, his urine became dark green. Serum total bilirubin and urine bilirubin were both elevated. We believe that the green discoloration of the urine was caused by propofol infusion and was related to impaired enterohepatic circulation and ...

Nobuki Shioya; Yoriko Ishibe; Shigehiro Shibata; Hideyuki Makabe; Shigenori Kan; Naoya Matsumoto; Gaku Takahashi; Yasuhiko Yamada; Shigeatsu Endo

2011-01-01

58

Pulsatile versus steady infusions for hepatic artery chemotherapy  

International Nuclear Information System (INIS)

Hepatic artery chemotherapy for unresectable liver tumors requires an even distribution of the drugs in the tumor or vascular bed. This cannot be determined angiographically because the drugs are infused at a much lower rate than the contrast media. It is easy, however, to determine the quality of the perfusion by injecting a small volume of Tc-99m MAA in one of the side ports while chemotherapeutic agent is being infused at the same rate. Usually this shows a uniform, satisfactory distribution of isotope. Occasionally, however, some areas fail to receive Tc-99m in spite of what appears to be a good position of the catheter tip. Since ''streaming'' of the infused drugs has been blamed for their uneven distribution, the authors decided to compare the usual steady flow infusions with infusions made pulsatile by the addition of a pulsing device (Gianturco Pump) attached to the infusion tubing. Eighty-three patients were studied with steady as well as pulsatile infusions. In 16 of these patients the perfusion pattern was definitely changed by the pulsatile infusion. In one patient the pulsatile mode resulted in an unwanted gastric perfusion. In 5 patients the distribution was improved in one hepatic lobe and in 10 patients it was improved in both lobes. These results show that hepatic artery perfusions can occasionally be improved by pulsing the infusate. However, pulsing can produce the unwanted perfusion of extra-hepatic areas

59

Quantitative evaluation of valvular regurgitation by 133Xenon infusion  

International Nuclear Information System (INIS)

Mitral and aortic regurgitation was evaluated by X-ray, dye dilution bolus, and 133Xenon infusion methods in 24 patients with mitral, aortic or both valve lesions. Good reproducibility was found using the 133Xenon infusion method. The regurgitant fraction estimated by 133Xenon constant infusion method correlates well with the results of the dye dilution method in mitral regurgitation as well as in aortic regurgitation. The 133Xenon infusion method is well-suited for quantitative evaluation of mitral and aortic regurgitation. For its simplicity, it is therefore recommended for further clinical evaluation in pharmacodynamic and preoperative studies. (author)

60

Rapid Lidocaine Infusion Sonohysterography and Biopsy  

Science.gov (United States)

Sonohysterography is an attractive alternative to hysteroscopy to detect intrauterine pathology. It is appropriate when sonography suggests pathology or is equivocal. Although it gives less information than hysteroscopy, it can be performed as part of the day's routine, requiring approximately 15 minutes. Two modifications are suggested, one for patient comfort and the other to improve diagnostic capability without altering the basic performance of the procedure. First, instead of normal saline, 1% lidocaine is the distention and contrast medium. Image enhancement is the same, and it provides a degree of analgesia for endometrial biopsy, if performed. Second, instead of an infusion catheter, any standard endometrial biopsy catheter may be used (in this case, the Milex suction endometrial biopsy vacurette). It is suitable for infusion and, while in place, may be used for a directed aspiration biopsy. The procedure was performed in 12 women and was technically satisfactory in 10. Findings necessitating tissue diagnosis were visualized in six patients, in five of whom a satisfactory (positive or exclusionary) diagnosis was obtained. Sonohysterography with lidocaine distention medium using a suction endometrial biopsy curette is a safe procedure for the diagnosis of postmenopausal bleeding and dysfunctional uterine bleeding. PMID:9074128

Goodman

1996-08-01

61

“Smart” Infusion Apparatus for Computation and Automated Delivery of Loading, Tapering, and Maintenance Infusion Regimens of Lidocaine, Procainamide, and Theophylline  

OpenAIRE

“Smart” infusion apparatus now computes loading and tapering infusion protocols to achieve and maintain chosen serum lidocaine levels for patients, using a 2-compartment model of lidocaine. The apparatus, an HP-41CV hand calculator with appropriate interface, delivers the regimen automatically, starting up and controlling an IVAC Model 1500 volumetric infusion pump with its IVAC computer interface module. The device appears capable of similar computation and automated administration of ma...

Nicholson, William F.; Jelliffe, Roger W.

1983-01-01

62

Evaluation of Talbot's Safety Zone of Infusion Volume and Osmolality in Infusion Therapy for Decompensated Liver Cirrhosis  

OpenAIRE

Problems with infusion therapy for correcting fluid and sodium imbalance in decompensated liver cirrhosis (DLC) were investigated by establishing the safety zone of Talbot et al. for parenteral fluid therapy in 4 DLC patients infused with over 900 ml of fluid each day for at least 9 days. The safety zone was different in each case. The safe infusion volume decreased and the safe electrolyte concentration shifted to a lower osmolality when there was ascites with renal failure than ascites w...

Yuasa, Shiro; Itoshima, Tatsuya; Ono, Ryosaku; Nagashima, Hideo

1985-01-01

63

A comparison of three different target-controlled remifentanil infusion rates during target-controlled propofol infusion for oocyte retrieval  

OpenAIRE

OBJECTIVE: To evaluate the effects of three different target-controlled remifentanil infusion rates during target-controlled propofol infusion on hemodynamic parameters, pain, sedation, and recovery score during oocyte retrieval. METHODS: Sixty-nine women were scheduled for oocyte retrieval. Target-controlled propofol infusion at an effectsite concentration of 1.5 ?g/mL was instituted. The patients were randomly allocated to receive remifentanil at an effect-site concentration of either ...

Demet Coskun; Berrin Gunaydin; Ayca Tas; Gozde Inan; Hulya Celebi; Kadir Kaya

2011-01-01

64

RF tumor ablation with internally cooled electrodes and saline infusion: what is the optimal location of the saline infusion?  

OpenAIRE

Abstract Background Radiofrequency ablation (RFA) of tumors by means of internally cooled electrodes (ICE) combined with interstitial infusion of saline may improve clinical results. To date, infusion has been conducted through outlets placed on the surface of the cooled electrode. However, the effect of infusion at a distance from the electrode surface is unknown. Our aim was to assess the effect of perfusion distance (PD) on the coagulation geometry and deposited power duri...

Cruz Ignacio; Gonzalez Ana; Subiró Jorge; Sousa Ramón; Grande Luis; Güemes Antonio; Burdío José M; Navarro Ana; Berjano Enrique J; Burdío Fernando; Castiella Tomás; Tejero Eloy; Lozano Ricardo; de Gregorio Miguel A

2007-01-01

65

Determination of 24-hour insulin infusion pattern by an artificial endocrine pancreas for intravenous insulin infusion with a miniature pump  

DEFF Research Database (Denmark)

UNLABELLED: Intravenous insulin infusion with a glucose controlled insulin infusion system (GCIIS) is known to restore glucose homeostasis. A simpler approach to improve blood glucose regulation is preprogrammed intravenous insulin infusion with portable pumps without sensor-mediated feedback. We report a study designed to evaluate whether the preprogrammed insulin infusion pattern to be used in the miniature insulin infusion pump (MIIP) could be optimized by concomitant employment of the GCIIS for blood glucose control. Six juvenile-onset insulin-dependent diabetics (mean age 31 yrs) were studied. Mean blood glucose (MBG) was 6.2 mmol/l +/- 0.5 (SD) during glucose controlled infusion and 5.3 +/- 0.6 during the combined MIIP + GCIIS-day. The insulin requirements calculated from the s.c. regimen (56 U +/- 10 SD) were identical to the GCIIS-measured (51 U +/- 14) and to the amounts delivered during the combined MIIP-GCIIS infusion day (54 U +/- 13). A mean surplus of 3 U was given by the GCIIS. Mean amplitude of glycaemic excursions (MAGE) was 3.0 mmol/l during GCIIS-control, and 3.3 mmol/l during combined infusion. IN CONCLUSION: The GCIIS was found capable of calculating the 24-hour insulin dose in well-known, unstable diabetics; however, it did not improve the preprogrammed insulin infusion profile obtained by the MIIP.

KØlendorf, K; Christiansen, J S

1981-01-01

66

Experimental study on intra-arterial infusion of basic fibroblast growth factor in the ischemic limbs of rabbit model  

International Nuclear Information System (INIS)

Objective: To evaluate the effect of intra-arterial infusion of basic fibroblast growth factor (bFGF) on improving neovascularization, vascular perfusion and the function of partially ischemic limbs of rabbits. Methods: Twenty-seven New Zealand male rabbits were selected. Partial ischemia model was induced by surgical ligation of the primary branches of right femoral artery in each animal, and the left hind limb of each animal was served as a nonischemic control. Then, 27 rabbits were randomly assigned to three groups: intra-arterial (IA) infusion of bFGF (n=9), intravenous (IV) infusion of bFGF and IA infusion of saline (n=9). Infusion was separately performed immediately after vascular ligation, 8th and 15th days post-surgery with 10 ?g (4 ml) of bFGF per-time (or the same volume of saline). The differences between three groups and between ischemic and nonischemic limbs of the same group were compared and evaluated by the following indexes: (1) vessel section count (VSC), vessel section surface area (VSS) and vessel section perimeter (VSP) in the field of ischemic muscle tissues taken at 22nd day postoperatively; (2) capillary refilling time of ischemic limbs; and (3) functional and trophic changes of ischemic limbs. Statistical differences were evaluated by one-way ANOVA and T test. Results: VSC, VSS and VSP of the IA-bFGF group were significantly increased than those of the IV-bFGF and IA-saline groups (P<0.01). At 22nd day postoperatively, the capillary refilliny postoperatively, the capillary refilling time, new hair growth, the appearance and function of all ischemic limbs in IA-bFGF group were approximately normal. However, in IA-saline group, the ischemic changes, capillary refilling time and the function of ischemic limbs were not improved significantly. All the indexes of IV-bFGF group showed no difference statistically from those of IA-saline group. Conclusions: This experimental study identifies that intra-arterial infusion of bFGF may significantly promote neovascularization and vascular perfusion in ischemic limbs, suggesting that a better effect may be obtained with IA-infusion bFGF than that of IV-infusion bFGF. (authors)

67

Sudden death due to intravenous infusion of hair conditioner.  

Science.gov (United States)

A case of sudden death in a 14-year-old girl due to self administration of hair conditioner through an intravenous infusion pump is described. This report demonstrates difficulties that may occur in determining the manner of death in such cases and outlines a specific danger that may occur when adolescents have unsupervised access to intravenous infusion equipment. PMID:9760091

Knight, D M; James, R A; Sims, D N; Bourne, A J; Martin, J; Byard, R W

1998-09-01

68

Inhibition of endogenous lactate turnover with lactate infusion in humans  

International Nuclear Information System (INIS)

The extent to which lactate infusion may inhibit endogenous lactate production, though previously considered, has never been critically assessed. To examine this proposition, single injection tracer methodology (U-14C Lactate) has been used for the estimation of lactate kinetics in 12 human subjects under basal conditions and with the infusion of sodium lactate. The basal rate of lactate turnover was measured on a day before the study with lactate infusion, and averaged 63.7 + 5.5 mg/kg/h. Six of these individuals received a stable lactate infusion at an approximate rate of 160 mg/kg/h, while the remaining six individuals were infused at the approximate rate of 100 mg/kg/h. It has been found that stable lactate infused at rates approximating 160 mg/kg/h consistently produced a complete inhibition of endogenous lactate production. Infusion of lactate at 100 mg/kg/h caused a lesser and more variable inhibition of endogenous lactate production (12% to 64%). In conclusion, lactate infusion significantly inhibits endogenous lactate production

69

Infusion of mature megakaryocytes into mice yields functional platelets  

OpenAIRE

Thrombopoiesis, the process by which circulating platelets arise from megakaryocytes, remains incompletely understood. Prior studies suggest that megakaryocytes shed platelets in the pulmonary vasculature. To better understand thrombopoiesis and to develop a potential platelet transfusion strategy that is not dependent upon donors, of which there remains a shortage, we examined whether megakaryocytes infused into mice shed platelets. Infused megakaryocytes led to clinically relevant increases...

Fuentes, Rudy; Wang, Yuhuan; Hirsch, Jessica; Wang, Cheng; Rauova, Lubica; Worthen, G. Scott; Kowalska, M. Anna; Poncz, Mortimer

2010-01-01

70

Intraarterial infusion chemotherapy for the treatment of metastatic liver cancer  

International Nuclear Information System (INIS)

Some techniques of the most recent interventional radiology are very useful for the treatment of metastatic liver cancer and changing the style of hepatic infusion chemotherapy. This report shows our latest results and methods of hepatic infusion chemotherapy for metastatic liver cancer. 1. For the catheter placement, a new catheterization route via the left subclavian artery into the hepatic artery was developed and performed in 132 cases. Superselective catheterization succeeded in 123 cases (93.2 %). This procedure is less invasive than laparotomy and less troublesome than other percutaneous routes. 2. For useful infusion system, an implantable injection port ''Reservoir'' was developed and it was used in 87 cases. This method makes arterial infusion chemotherapy easy, and imploves their quality of life. 3. To acquire adequate drug delivery, arterial redistribution by steel coils was done, and 109 arteries in 80 cases were occluded. This method is very useful to make multiple hepatic artery single and it is important to avoid gasroduodenal complications. 4. Now, using these techniques, the phase II study of 5FU, ADM, MMC combined hepatic infusion in patients with non-resectable metastatic liver cancer is done. Up to this time, such a phase study on arterial infusion chemotherapy was difficult because of technical problems, but these new techniques make it possible. In conclusion, these new methods change the style and conception of hepatic infusion, and these make ption of hepatic infusion, and these make much progress on the treatment of patients with metastatic liver cancer. (author)

71

Brain activity following esophageal acid infusion using positron emission tomography  

Directory of Open Access Journals (Sweden)

Full Text Available AIM: To investigate symptoms and brain activity following esophageal acid infusion.METHODS: Fifteen healthy volunteers were recruited for the study. Hydrochloric acid (pH 1 and 2 and distilled water (pH 7 were randomly and repeatedly infused into the esophagus. The brain activity was evaluated by positron emission tomography. The severity of heartburn elicited by the infusion was rated on an auditory analog scale of 0-10.RESULTS: The severity of heartburn following each infusion showed a step-wise increase with increasing acidity of the perfusate. The heartburn scores were significantly higher in the second pH 1 infusion compared with the first infusion. Acid and distilled water infusion induced activation of various brain areas such as the anterior insula, temporal gyrus, and anterior/posterior cingulate cortex. At pH 1 or 2, in particular, activation was observed in some emotion-related brain areas such as the more anterior part of the anterior cingulate cortex, parahippocampal gyrus, or the temporal pole. Strong activation of the orbitofrontal cortex was found by subtraction analysis of the two second pH 1 infusions, with a significant increase of heartburn symptoms.CONCLUSION: Emotion-related brain areas were activated by esophageal acid stimulation. The orbitofrontal area might be involved in symptom processing, with esophageal sensitization induced by repeated acid stimulation.

Shigeyuki Kobayashi, Yasuhiko Abe, Manabu Tashiro, Tomoyuki Koike, Katsunori Iijima, Akira Imatani, Shuichi Ohara, Satoshi Watanabe, Shin Fukudo, Tooru Shimosegawa

2010-11-01

72

Evaluation of platelet deposition at local thrombophlebitis, caused by intravenous infusion of anticancer drug (Bisantrene), with In-111-platelets in rabbits  

International Nuclear Information System (INIS)

Several anticancer drugs produce localized thrombophlebitis (LTP) when infused intravenously and LTP is the dose-limiting factor. LTP was studied in New Zealand albino rabbits by I.V. infusion of Bisantrene (BS: ? 40 mg/rabbit, six rabbits via ear veins, five via jugular veins, two control, 0.9% saline). Radioactivity in three sections of each harvested vein was determined with a gamma counter, and the ratio of radioactivity per mg of infused vein and control vein was determined and the results are presented in this paper. Scanning electron micrograph of BS-infused vein lumen revealed plaques of amorphous material (BS) and adherent platelet thrombus. Platelet deposition at BS-induced LTP in jugular and ear veins reached a maximum at four to eight hours. Thus, LTP could be imaged and quantified with In-111-labeled platelets

73

Thallium-201 myocardial scintigraphy after dipyridamole infusion  

International Nuclear Information System (INIS)

Thallium-201 myocardial imaging after exercise is widely used for the detection of coronary artery disease. This study was performed to introduce thallium-201 myocardial imaging after infusion of dipyridamole (Persantin), a potent coronary dilator. This non-invasive method can be used for patients unable to perform sufficient exercise. Fifty-three patients (40 men and 13 women) with a syndrome with chest pain who were unable to perform sufficient exercise were studied with dipyridamole-thallium imaging and coronary arteriography. 39 patients (74%) had significant coronary artery disease. There were 33 patients (62%) with a positive dipyridamole-thallium imaging. They all had significant coronary artery disease. Sensitivity and specificity were 85% and 100%, respectively. (Auth.)

74

Continuous subcutaneous insulin infusion (CSII) pumps.  

Science.gov (United States)

Optimal blood glucose control and the restoration of the physiological insulin secretion is a current medical challenge andwill account for an overall cardiovascular morbidity and mortality related to diabetes mellitus complications. Continuous Subcutaneous Insulin Infusion (CSII) is the first step to the development of the so-called "artificial pancreas" and is intended to restore blood glucose levels and the frequency of hypoglycemic episodes. CSII using an external pump, offers both a better glycemic profile compared to multiple daily insulin injections (MDI) and a broader flexibility in everyday activities. The advantages of insulin pumps, i.e., basal delivery consistency, adjustable basal rates and low insulin depots also contribute to its reported clinical superiority. However, experience with CSII indicates that candidate patients should be carefully selected, thoroughly educated and vividly motivated to improve their blood glucose control. PMID:23393693

Valla, Vasiliki

2012-01-01

75

Accelerated infliximab infusions for inflammatory bowel disease improve effectiveness  

Directory of Open Access Journals (Sweden)

Full Text Available AIM: To study the safety and effectiveness associated with accelerated infliximab infusion protocols in patients with inflammatory bowel disease (IBD. METHODS: Original protocols and infusion rates were developed for the administration of infliximab over 90-min and 60-min. Then the IBD patients on stable maintenance infliximab therapy were offered accelerated infusions. To be eligible for the study, patients needed a minimum of four prior infusions. An initial infusion of 90-min was given to each patient; those tolerating the accelerated infusion were transitioned to a 60-min infusion protocol at their next and all subsequent visits. Any patient having significant infusion reactions would be reverted to the standard 120-min protocol. A change in a patient’s dose mandated a single 120-min infusion before accelerated infusions could be administered again. RESULTS: The University of Virginia Medical Center's Institutional Review Board approved this study. Fifty IBD patients treated with infliximab 5 mg/kg, 7.5 mg/kg and 10 mg/kg were offered accelerated infusions. Forty-six patients consented to participate in the study. Nineteen (41.3% were female, five (10.9% were African American and nine (19.6% had ulcerative colitis. The mean age was 42.6 years old. Patients under age 18 were excluded. Ten patients used immunosuppressive drugs concurrently out of which six were taking azathioprine, three were taking 6-mercaptopurine and one was taking methotrexate. One of the 46 study patients used corticosteroid therapy for his IBD. Seventeen of the patients used prophylactic medications prior to receiving infusions; six patients received corticosteroids as pre-medication. Four patients had a history of distant transfusion reactions to infliximab. These reactions included shortness of breath, chest tightness, flushing, pruritus and urticaria. These patients all took prophylactic medications before receiving infusions. 46 patients (27 males and 19 females received a total of fifty 90-min infusions and ninety-three 60-min infusions. No infusion reactions were reported. There were no adverse events, including drug-related infections. None of the patients developed cancer of any type during the study timeframe. Total cost savings for administration of the both 90-min and 60-min accelerated infusions compared to standard 120-min infusions was estimated to be $53?632 ($116?965 vs $63?333, P = 0.001. One hundred and eighteen hours were saved in the administration of the accelerated infusions (17?160 min vs 10?080 min, P = 0.001. In the study population, overweight females [body mass index (BMI > 25.00 kg/m2] were found to have statistically higher BMIs than overweight males (mean BMI 35.07 ± 2.66 kg/m2 vs 30.08 ± 0.99 kg/m2, P = 0.05, finding which is of significance since obesity was described as being one of the risk factors for Crohn’s disease. CONCLUSION: We are the first US group to report substantial cost savings, increased safety and patient satisfaction associated with accelerated infliximab infusion.

John McConnell

2012-01-01

76

Superselective intraarterial infusion therapy for head and neck carcinomas  

International Nuclear Information System (INIS)

We report the results of superselective intraarterial cisplatin (CDDP) infusion therapy combined with irradiation for 23 patients, mainly advanced head and neck carcinoma. All patients received intraarterial CDDP infusions with intravenous sodium thiosulfate (STS) neutralization. CDDP infusion was performed by the Seldinger's technique in 16 patients and by the implanted intraarterial reservoir system in 7 patients. STS was also infused by the reservoir system implanted at the forearm in most patients. An overall response was observed in 21 of the 23 (91.3%) patients. Complete and partial responses were achieved in 16 (69.6%) and 5 (21.7%) patients, respectively. There were no patients with worse than grade III complications. We concluded that superselective intraarterial infusion therapy with a high dose of CDDP and STS was very effective for the management of advanced head and neck carcinomas and we recommend the implantable reservoir system for both CDDP and STS administration as an easy and low-invasive method. (author)

77

Evaluation of a rapid infusion system.  

Science.gov (United States)

Operative cases where there is a potential for massive blood loss necessitates a system to rapidly warm and transfuse large volumes of blood over short periods of time. An in-house system in which both crystalloid solutions and blood products can be quickly added, warmed and available for infusion was developed to meet this need. The purpose of this study was to evaluate how blood products are affected when warmed and recirculated for an extended period of time. A recirculating rapid infusion system was assembled utilizing two filtered cardiotomy reservoirs, a centrifugal pump, a stainless steel blood heat exchanger, and 1/4 inch tubing, and applied in six adult orthotopic liver transplantations. The system was primed with 2 to 4 units each of fresh frozen plasma and packed red blood cells. The prime was recirculated and warmed to 37 degrees C. Samples for blood gases, oxygen saturation, hematocrit, plasma free hemoglobin, sodium and potassium levels were drawn after initial priming and then every 30 minutes until additional blood products were added. Results show no significant change in pH (6.57 +/- 0.21), pO2 (56 mmHg +/- 23 mmHg), pCO2 (173 mmHg +/- 138 mmHg), hematocrit (27% +/- 8.7%) and plasma free hemoglobin values (125 mg/dl +/- 9.4 mg/dl), following 3 hours of recirculation. However, potassium levels significantly decreased from 11.6 meq/L +/- 2.6 meq/L to 10.0 meq/L +/- 2.3 meq/L (p < 0.05), sodium levels significantly increased from 144 meq/L +/- 5.9 meq/L to 147 meq/L +/- 5.3 meq/L (p < 0.05) and oxygen saturations significantly increased from 59% +/- 9.1% to 70% +/- 16% (p < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS) PMID:10150685

Cronbaugh, R; Ploessl, J; Sutton, R; Martin, M

1994-12-01

78

Evaluation of maternal infusion therapy during pregnancy for fetal development  

Directory of Open Access Journals (Sweden)

Full Text Available The aim of this project was to study the possible association between maternal infusion treatments during pregnancy and variables of fetal development as well as the occurrence of congenital abnormalities (CA in a case-control design. The large population-based data set of the Hungarian Case?Control Surveillance of Congenital Abnormalities (HCCSCA was evaluated based on the medically recorded infusion treatment during pregnancy. Of 22,843 case pregnant women who had newborns or fetuses with congenital abnormalities, 112 (0.5%, while of 38,151 control pregnant women who had newborn infants without any defects, 262 (0.7%, had infusion treatment during pregnancy. Infusion treatment was more frequent in the control group than in the case group with congenital abnormalities (adjusted POR with 945 95% CI: 0.7, 0.6-0.9 and there was no higher rate of maternal infusion treatments in any congenital abnormality group. Mean gestational age was shorter and mean birth weight was smaller in control newborn infants without CA born to mothers with infusion treatment during pregnancy than in the babies of mothers without infusion treatment. The prevalence of mild intrauterine growth retardation was more frequent in the fetuses of pregnant women with hyperemesis gravidarum treated with infusion. The results of the study suggest that infusion treatment of pregnant women did not associate with a higher risk of congenital abnormalities. In addition, the intravenous infusion of drugs has some, but limited efficacy to prevent the adverse effects of hyperemesis gravidarum and threatened preterm delivery.

2005-10-01

79

Patient preferences and satisfaction in a multispecialty infusion center  

Directory of Open Access Journals (Sweden)

Full Text Available Barbara E Ostrov,1 Kristine Reynolds,2 Lisabeth V Scalzi11Departments of Pediatrics and Medicine, 2Department of Nursing, Penn State Hershey Medical Center, Hershey, PA, USAPurpose: Direct feedback from patients about their preferred modes of medication ­administration has been increasingly sought by providers to develop care programs that best match patient goals. Multispecialty infusion centers generally provide care to hematology–oncology (HO and non-HO patients in one unit, with the same nursing staff. Our staff perceived that this was dissatisfying to our non-HO patients. We assessed patient satisfaction, as well as nursing and physician perceptions of patient preference/satisfaction with our infusion center, to determine whether a separate unit should be recommended when designing our new Cancer Institute Infusion Center.Patients and methods: A seven-question Likert scale satisfaction survey for patients, and a separate survey to assess nurses’ and physicians’ perception of patient satisfaction, were developed. The survey was administered to non-HO patients receiving infusions, doctors prescribing infusions, and nurses administering infusions. Results of the survey were compared between groups to assess differences in responses.Results: Responses were received from 52 non-HO patients, 18 physicians, and 13 nurses. Patients had more satisfaction, on all survey items, with the multispecialty infusion center than had been realized by physicians and nurses. Analysis demonstrated that patients were satisfied with care in a multispecialty infusion unit and were in favor of continuing their care in this combined center. Total scores of patient surveys were significantly different (P<0.001 from those of physicians and nurses, who had assumed patients would prefer to have their care in a non-HO infusion setting.Conclusion: Understanding patient preferences is an important step in deciding the structure of infusion centers. Based on these survey conclusions, a combined multispecialty infusion center has been continued at our institution, thus improving quality by including patients in decision-making affecting their care.Keywords: patient care, infusion preferences, non-oncology patients, infusion therapy

Ostrov BE

2014-05-01

80

Errors of intravenous fluid infusion rates in medical inpatients.  

Science.gov (United States)

Prescriptions for intravenous (i.v.) fluids in hospitals may not be closely adhered to. This study prospectively examined whether prescribed i.v. fluids are administered at the correct rate. During a four-week period, the i.v. infusion rates in patients requiring continuous i.v. fluids and cared for by a single medical team in a district hospital were studied. The periods over which i.v. crystalloid fluid bags were administered were compared with the time prescribed. Of a total 207 bags, 53 (26%) were correctly administered at the prescribed rate (percentage error 10% to -10%), 138 bags (67%) were infused too slowly and 16 bags (8%) were infused too fast. Overall, the median (interquartile range) absolute percentage error (positive or negative) for all infused bags was 23% (9.7-50). Thirty-nine per cent of bags were infused accurately when a metered pump was used, compared to 21% of bags infused accurately when a metered pump was not used (p Metered pumps improve accuracy. Increased awareness of such errors, and the routine use of metered pumps should help improve the accuracy of i.v. fluid infusion rates. PMID:17990717

Rooker, Jemma C; Gorard, David A

2007-10-01

81

Randomised controlled trial of colloid infusions in hypotensive preterm infants.  

OpenAIRE

Colloid infusions are often given to treat hypotension in preterm infants. The aim of this work was to assess whether it was the amount of protein or the volume of the colloid infused which accounted for the observed increase in blood pressure. Sixty preterm infants were randomised (20 in each group) to receive 5 ml/kg 20% albumin, 15 ml/kg fresh frozen plasma, or 15 ml/kg 4.5% albumin. All infusions were given at a rate of 5 ml/kg/hour in addition to maintenance fluids. The infants were rand...

Emery, E. F.; Greenough, A.; Gamsu, H. R.

1992-01-01

82

Hepatobiliary scintigraphy in patients receiving hepatic artery infusion chemotherapy  

International Nuclear Information System (INIS)

Hepatic artery infusion chemotherapy is used in the treatment of certain selected hepatic tumors, especially metastatic adenocarcinoma of the colon. Chemical cholecystitis has been recognized recently as a complication of hepatic artery infusion chemotherapy. The authors performed hepatobiliary scans on ten patients receiving hepatic artery infusion chemotherapy. All ten patients had abnormal hepatobiliary scintigraphy. They present case reports of three patients with abnormal hepatobiliary scans who have required cholecystectomy for symptoms of chemical cholecystitis to illustrate the clinical, scintigraphic, and pathologic findings in these patients

83

Intestinal levodopa infusion: the Belgian experience.  

Science.gov (United States)

Data concerning efficacy, safety, and patient satisfaction of levodopa/carbidopa intestinal gel (LCIG, Duodopa, AbbVie, Wavre, Belgium) infusion in routine clinical practice were needed to maintain reimbursement of the drug in Belgium. Patients with advanced Parkinson's disease in 27 neurology centers across Belgium were included. Of 100 patients who underwent naso-intestinal (NI) evaluation with LCIG, 67 received permanent treatment with LCIG via percutaneous endoscopic gastrostomy and jejunal tube (PEG/J). Efficacy was evaluated at baseline (on levodopa) and during a follow-up (FU) visit (on LCIG) using the Unified Parkinson's Disease Rating Scale (UPDRS) IV. Patient appraisal of the Duodopa system was evaluated using a visual analog scale for therapy compliance, user-friendliness, and global appreciation. Safety was assessed by reporting suspected adverse drug reactions (ADRs) and medical device-related complaints. FU evaluations were conducted in 37 patients. Significant improvement at FU was observed for motor complications (UPDRS IV) as the mean change from baseline to FU was -6.3 (95 % CI -8.1 to -4.5). Patient appraisal showed high scores for hospital delivery, user-friendliness, and patient global appreciation, as well as family appreciation of the system on daily life. Few ADRs and system malfunctions were reported, with no unexpected ADRs. In conclusion, the symptoms and impact of Parkinsonism improved markedly when LCIG PEG/J was initiated. PMID:24379105

Pickut, Barbara Anne; van der Linden, Chris; Dethy, Sophie; Van De Maele, Hilde; de Beyl, Diederik Zegers

2014-06-01

84

Saline infusion sonohysterosalpingography, an underutilized technique.  

Science.gov (United States)

Saline infusion sonohysterography (SIS) is an important gynaecological diagnostic tool which is little used in Australia. We herein report the findings in 60 women referred for SIS, the procedure being uneventfully performed in 55. Forty-nine of the 60 referrals were for investigation of abnormal uterine bleeding. The technique described allows examination of the uterine cavity and the Fallopian tubes. In 26 of the patients information was obtained which improved or altered the diagnosis made on B mode and colour Doppler ultrasound. Unlike hysteroscopy, SIS is always performed as an outpatient procedure, appropriate disinfection procedures are relatively simple to implement (1), and vasovagal reactions are rare. Hysteroscopy was avoided in 11 patients, there were other benefits in 4 patients, and in only 1 of 16 patients did the hysteroscopy findings differ with SIS. If diagnostic pitfalls are avoided by careful attention to detail, SIS offers a powerful new gynaecological investigative tool in the investigation of bleeding disorders (including menorrhagia, intermenstrual and postmenopausal bleeding), uncertain endometrial findings on vaginal ultrasound, infertility, and in the investigation of congenital and acquired uterine abnormalities. PMID:9222469

de Crespigny, L; Kuhn, R; McGinnes, D

1997-05-01

85

“Smart” Infusion Apparatus for Computation and Automated Delivery of Loading, Tapering, and Maintenance Infusion Regimens of Lidocaine, Procainamide, and Theophylline  

Science.gov (United States)

“Smart” infusion apparatus now computes loading and tapering infusion protocols to achieve and maintain chosen serum lidocaine levels for patients, using a 2-compartment model of lidocaine. The apparatus, an HP-41CV hand calculator with appropriate interface, delivers the regimen automatically, starting up and controlling an IVAC Model 1500 volumetric infusion pump with its IVAC computer interface module. The device appears capable of similar computation and automated administration of many other drugs such as procainamide and theophylline. Preliminary upward adjustments of the regimen can also be made in the apparatus now, without recourse to an external computer.

Nicholson, William F.; Jelliffe, Roger W.

1983-01-01

86

A new infusion pathway monitoring system utilizing electrostatic induced potential.  

Science.gov (United States)

We have developed a new infusion pathway monitoring system employing linear integrated circuits and a low-power 8-bit single chip microcomputer. The system is available for hospital and home use and it constantly monitors the intactness of the pathway. The sensor is an electro-conductive polymer electrode wrapped around the infusion polyvinyl chloride infusion tube. This records an AC (alternating current) voltage induced on the patient's body by electrostatic coupling from the normal 100 volt, 60 Hz AC power line wiring field in the patient's room. If the injection needle or infusion tube becomes detached, then the system detects changes in the induced AC voltage and alerts the nursing station, via the nurse call system or PHS (personal handy phone System). PMID:16817637

Maki, Hiromichi; Yonezawa, Yoshiharu; Ogawa, Hidekuni; Ninomiya, Ishio; Sada, Kouji; Hamada, Shingo; Hahn, Alien W; Caldwell, W Morton

2006-01-01

87

Infusing Social Responsibility into the Curriculum and Cocurriculum: Campus Examples  

Science.gov (United States)

This chapter highlights good practices and lessons learned for infusing social responsibility--contributing to the larger community and taking seriously the perspectives of others--as outcomes of college.

Reason, Robert D.

2013-01-01

88

Radionuclide localization of intraarterial infusions in head and neck cancer  

Energy Technology Data Exchange (ETDEWEB)

The therapeutic advantage of intraarterial infusion chemotherapy depends upon delivery of a high drug concentration to the entire tumor bulk with maximum sparing of critical normal tissues. It is clear that successful application of regional therapy must include methodology to assess quantitatively and qualitatively the infused area. /sup 99m/Tc macroaggregated albumin (Tc-MAA) injected intraarterially is held on first pass in the arteriolar capillary bed, thus providing a map of blood flow distribution. Analog and digital planar images and single photon emission computed tomography (SPECT) after Tc-MAA injections provide static and transaxial tomographic images of head and neck intraarterial infusions. SPECT can be viewed as an endless movie-type display, thus producing a rotating cimematic display. These radionuclide localization techniques provide a three-dimensional delineation of the tissues infused, including subsurface details not appreciated with dye injection alone. These procedures should be considered an integral part of intraarterial therapy of head and neck cancer.

Baker, S.R.; Wheeler, R.H.; Ziessman, H.A.; Medvec, B.R.; Thrall, J.H.; Keyes, J.W. Jr.

1984-01-01

89

Radionuclide localization of intraarterial infusions in head and neck cancer.  

Science.gov (United States)

The therapeutic advantage of intraarterial infusion chemotherapy depends upon delivery of a high drug concentration to the entire tumor bulk with maximum sparing of critical normal tissues. It is clear that successful application of regional therapy must include methodology to assess quantitatively and qualitatively the infused area. 99mTc macroaggregated albumin (Tc-MAA) injected intraarterially is held on first pass in the arteriolar capillary bed, thus providing a map of blood flow distribution. Analog and digital planar images and single photon emission computed tomography (SPECT) after Tc-MAA injections provide static and transaxial tomographic images of head and neck intraarterial infusions. SPECT can be viewed as an endless movie-type display, thus producing a "rotating cimematic display." These radionuclide localization techniques provide a three-dimensional delineation of the tissues infused, including subsurface details not appreciated with dye injection alone. These procedures should be considered an integral part of intraarterial therapy of head and neck cancer. PMID:6336207

Baker, S R; Wheeler, R H; Ziessman, H A; Medvec, B R; Thrall, J H; Keyes, J W

1984-01-01

90

Radionuclide localization of intraarterial infusions in head and neck cancer  

International Nuclear Information System (INIS)

The therapeutic advantage of intraarterial infusion chemotherapy depends upon delivery of a high drug concentration to the entire tumor bulk with maximum sparing of critical normal tissues. It is clear that successful application of regional therapy must include methodology to assess quantitatively and qualitatively the infused area. /sup 99m/Tc macroaggregated albumin (Tc-MAA) injected intraarterially is held on first pass in the arteriolar capillary bed, thus providing a map of blood flow distribution. Analog and digital planar images and single photon emission computed tomography (SPECT) after Tc-MAA injections provide static and transaxial tomographic images of head and neck intraarterial infusions. SPECT can be viewed as an endless movie-type display, thus producing a rotating cimematic display. These radionuclide localization techniques provide a three-dimensional delineation of the tissues infused, including subsurface details not appreciated with dye injection alone. These procedures should be considered an integral part of intraarterial therapy of head and neck cancer

91

Parathyroid scanning with 75Se selenomethionine after EDTA-infusion  

International Nuclear Information System (INIS)

In four patients with primary hyperparathyroidism, of which three had already received surgery, hyperfunctioning parathyroid tissue was localised by parathyroid 75Se Selenomethionine scintiscanning after EDTA-infusion. In one patient the same result could be achieved without EDTA. It was suggested that parathyroid 75Se Selenomethionine scanning after EDTA-infusion could be a useful tool in patients with primary hyperparathyroidism, especially in cases in which surgery had been unsuccessful. (author)

92

Tuboovarian abscess after saline infusion sonohysterography: an unusual complication.  

Science.gov (United States)

A 45-year-old woman, nulligravida, who underwent saline infusion sonohysterography for infertility evaluation experienced fever and pelvic pain 7 days after the procedure. Transvaginal ultrasonography and computed tomography of the abdomen and pelvis revealed bilateral tuboovarian abscesses (TOA). Because of persistent febrile morbidity despite treatment with broad-spectrum parenteral antibiotics, the TOA were drained under computed tomography guidance. We believe is the first reported case of TOA after saline infusion sonohysterography. PMID:19835815

Shavell, Valerie I; Le, Isabelle P; Yelian, Frank D

2009-01-01

93

Modern Methods of Infusion Therapy in Patients with Shock  

OpenAIRE

The aim of the investigation is the assessment of the effect of various variant of infusion therapy on the function of organs and systems of patients with hemorrhagic and traumatic shock. Materials and methods. There have been presented the results of the single-blind prospective cohort randomized study (by envelope technique) of 219 patients with hemorrhagic and traumatic shock divided into group depending on infusion therapy variant. Results. The use of 6% hydroxyethylated starch colloid so...

Girsh, ?. ?.; Stukanov, ?. ?.; Yudakova, ?. N.; Mamontov, V. V.; Maksimishin, S. V.

2012-01-01

94

Infusion cholecystography in the diagnosis of acute cholecystitis  

International Nuclear Information System (INIS)

The use of infusion cholecystography as an aid in the diagnosis of acute cholecystitis was investigated in 21 patients. Seventeen of 18 patients (94%) with positive cholecyst-tomograms who underwent laparotomy had confirmation of acutely inflamed gallbladders both macroscopically and histologically. These findings suggest that infusion cholecystography can make a significant contribution in reducing the incidence of misdiagnosis in acute cholecystitis, and that the investigation should be part of the management of patients in whom early surgery is planned. (author)

95

Numerical Simulation Study on the Coal Seam Pulse Water Infusion  

OpenAIRE

In the process of coal seam pulse water infusion, liquid-solid coupling effect exists in coal seam between the stress field and seepage field. Based on the basic principle of liquid-solid coupling, the dynamic liquid-solid coupling effect of stress and seepage field during coal seam pulse water infusion is simulated through secondary development of ABAQUS software, during this process the mathematical model of the strain accumulation model due to the periodic ...

Meng Junqing; Zhao Bi; Ma Yechao

2014-01-01

96

Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile  

OpenAIRE

Background Recurrent Clostridium difficile infection is difficult to treat, and failure rates for antibiotic therapy are high. We studied the effect of duodenal infusion of donor feces in patients with recurrent C. difficile infection. Methods We randomly assigned patients to receive one of three therapies: an initial vancomycin regimen (500 mg orally four times per day for 4 days), followed by bowel lavage and subsequent infusion of a solution of donor feces through a nasoduodenal tube; a st...

Nood, E.; Vrieze, A.; Nieuwdorp, M.; Fuentes Enriquez Salamanca, S.; Zoetendal, E. G.; Vos, W. M.; Visser, C. E.; Kuijper, E. J.; Bartelsman, J. F.; Tijssen, J. G.; Speelman, P.; Dijkgraaf, M. G.; Keller, J. J.

2013-01-01

97

Limited water infusion decreases pain during minimally sedated colonoscopy  

OpenAIRE

AIM: To investigate a limited water infusion method in colonoscopy. METHODS: Consecutive patients undergoing minimally sedated colonoscopy were randomized to receive air insufflation (n = 89) or water infusion limited to the rectum, sigmoid colon and descending colon (n = 90). Completion rates, cecal intubation times, procedure times, need for abdominal compression, turning of patients and levels of discomfort were evaluated. RESULTS: Completion rates, total procedure times, need for abdomina...

Kuo-Chih Tseng; Hwai-Jeng Lin; Yu-Hsi Hsieh

2011-01-01

98

Infusing Software Engineering Technology into Practice at NASA  

Science.gov (United States)

We present an ongoing effort of the NASA Software Engineering Initiative to encourage the use of advanced software engineering technology on NASA projects. Technology infusion is in general a difficult process yet this effort seems to have found a modest approach that is successful for some types of technologies. We outline the process and describe the experience of the technology infusions that occurred over a two year period. We also present some lessons from the experiences.

Pressburger, Thomas; Feather, Martin S.; Hinchey, Michael; Markosia, Lawrence

2006-01-01

99

[Behavioural impairments and hallucinations after consumption of boldo leaf infusions].  

Science.gov (United States)

We report a case of behavioural impairments with hallucinations in a twelve-year-old girl, after consumption of boldo leaf infusions. The main alkaloid of boldo, named boldine, is very likely responsible for temporary neuropsychiatric disturbances present in the patient. The emergence of behavioural problems and hallucinations without any obvious cause, should lead to search for consumption of boldo leaf infusion ("tisanes"). This consumption must be avoided in children. PMID:25230279

Chaboussant, Pierre-Jacques; Gagez, Anne-Laure; Graber, Marianne; Zhao, Jean-Michel; Chavant, François; Perault-Pochat, Marie-Christine; Graber, Denis

2014-01-01

100

Electro-osmotic infusion for joule heating soil remediation techniques  

Science.gov (United States)

Electro-osmotic infusion of ground water or chemically tailored electrolyte is used to enhance, maintain, or recondition electrical conductivity for the joule heating remediation technique. Induced flows can be used to infuse electrolyte with enhanced ionic conductivity into the vicinity of the electrodes, maintain the local saturation of near-electrode regions and resaturate a partially dried out zone with groundwater. Electro-osmotic infusion can also tailor the conductivity throughout the target layer by infusing chemically modified and/or heated electrolyte to improve conductivity contrast of the interior. Periodic polarity reversals will prevent large pH changes at the electrodes. Electro-osmotic infusion can be used to condition the electrical conductivity of the soil, particularly low permeability soil, before and during the heating operation. Electro-osmotic infusion is carried out by locating one or more electrodes adjacent the heating electrodes and applying a dc potential between two or more electrodes. Depending on the polarities of the electrodes, the induced flow will be toward the heating electrodes or away from the heating electrodes. In addition, electrodes carrying a dc potential may be located throughout the target area to tailor the conductivity of the target area.

Carrigan, Charles R. (Tracy, CA); Nitao, John J. (Castro Valley, CA)

1999-01-01

101

Prepreg and infusion processes for modern wind turbine blades  

Energy Technology Data Exchange (ETDEWEB)

The different elements of wind turbine blades have been analyzed for their main function, performance requirements and drivers. Key drivers can be simplified to either performance or cost. The use of prepreg and infusion to make these blade elements has then been compared and shows, from a comparison of test laminates, that prepreg typically delivers higher mechanical performance on both glass and carbon. One of the main process differences, cure temperature, has been overcome with the introduction of M79 which cures at 70 deg. - 80 deg. C. M79 combines this low cure temperature with a much lower reaction enthalpy allowing shorter cure cycles. This means that prepregs can now be cured in the same molds, at the same temperatures and with the same foam as used in a conventional infusion process. Although prepreg and infusion are usually used separately for making blade elements, they may also be used in combination: co-infused and co-cured using prepregs for the hard to infuse unidirectional load-carrying elements and infusion for the other elements. This can thus simplify the production process. The conclusion is that unidirectional prepregs are ideally suited for the performance driven parts of the blade such as in load carrying elements. (Author)

Shennan, C. [Hexcel, Cambridge (United Kingdom)

2013-09-01

102

Lipolytic response to glucose infusion in human subjects  

Energy Technology Data Exchange (ETDEWEB)

The authors have determined the effect of various rates of glucose infusion on the rates of release of glycerol (R/sub a/ glycerol), free fatty acids (R/sub a/ FFA), and on energy metabolism in normal human volunteers. Plasma kinetics were determined with use of the stable isotopic tracers D-5-glycerol and (1- TC)palmitate, and energy metabolism was determined by indirect calorimetry. The effect of glucose infusion on R/sub a/ glycerol and R/sub a/ FFA was dose-dependent. At 4 mg x kg x min , both R/sub a/ glycerol and R/sub a/ FFA were suppressed; at 8 mg x kg x min , R/sub a/ FFA was even more depressed, but R/sub a/ glycerol was similar to the value during the 4 mg x kg x min infusion. At all infusion rates tested, the amount of potential energy available from the sum of the glucose infusion and endogenously mobilized fat was always greater than when no glucose was infused. Glucose decreased fat mobilization by both inhibiting lipolysis and stimulating reesterification, thus causing a significant increase in triglyceride-fatty acid substrate cycling within the adipose tissue. Plasma insulin was determined by radioimmunoassay.

Wolfe, R.R.; Peters, E.J.

1987-02-01

103

Lipolytic response to glucose infusion in human subjects  

International Nuclear Information System (INIS)

The authors have determined the effect of various rates of glucose infusion on the rates of release of glycerol (R/sub a/ glycerol), free fatty acids (R/sub a/ FFA), and on energy metabolism in normal human volunteers. Plasma kinetics were determined with use of the stable isotopic tracers D-5-glycerol and [1-13C]palmitate, and energy metabolism was determined by indirect calorimetry. The effect of glucose infusion on R/sub a/ glycerol and R/sub a/ FFA was dose-dependent. At 4 mg x kg-1 x min-1, both R/sub a/ glycerol and R/sub a/ FFA were suppressed; at 8 mg x kg-1 x min-1, R/sub a/ FFA was even more depressed, but R/sub a/ glycerol was similar to the value during the 4 mg x kg-1 x min-1 infusion. At all infusion rates tested, the amount of potential energy available from the sum of the glucose infusion and endogenously mobilized fat was always greater than when no glucose was infused. Glucose decreased fat mobilization by both inhibiting lipolysis and stimulating reesterification, thus causing a significant increase in triglyceride-fatty acid substrate cycling within the adipose tissue. Plasma insulin was determined by radioimmunoassay

104

Tracer studies with aortic infusion result in improper tracer distribution  

International Nuclear Information System (INIS)

It has been suggested that lactate turnover can be accurately assessed by infusing radioactive lactate tracer into the aorta and sampling blood in the vena cava. However, there may be streaming of newly infused tracer in the aorta, resulting in a nonuniform arterial specific activity (SA). Furthermore vena caval blood may not be representative of mixed venous blood. The authors examined this problem in 7 anesthetized dogs with sampling catheters in the pulmonary (PA), carotid (CA), and femoral (FA) arteries, and the superior (SVC) and inferior (IVC) vena cavi. [1-14C]lactate was continuously infused into the left ventricle through a catheter introduced through the femoral artery. The same SA (dpm/?mol) was found in the CA and FA, indicating adequate mixing of newly infused tracer with trace. Three dogs showed differences between SVC, IVC and PA, suggesting a mixed venous sample can not be obtained from the VC. When the catheter was moved into the aorta, wide differences in SA appeared between the CA and FA, clearly reflecting streaming of tracer. These differences also appeared in the SVC and IVC. In conclusion, adequate mixing does not occur between tracer and trace in arterial blood with aortic infusion. Further, VC sampling will not give a consistent mixed venous SA. Therefore, for practical reasons, aortic tracer infusion with vena caval sampling will lead to erroneous turnover values

105

The Effects on Toxicity of Circadian Patterning of Continuous Hepatic Artery Infusion  

OpenAIRE

Long term continuous hepatic artery infusion of FUDR was carried out in 34 rats. In the animals who received a constant infusion schedule of 15mg/kg/day all died of toxicity with a mean survival of 9.3 days. If the pattern of the continuous infusion was changed so that over 60% of the infusion was given during the hours of 3pm to 9pm then all of the animals survived the 14 day infusion. If the maximum dose of infusion was changed so that 60% of the infusion was given at night from...

Kemeny, M. Margaret; Alava, Galo; Oliver, Jorge M.; Smith, Fred B.

1992-01-01

106

Planetary Science Technology Infusion Study: Findings and Recommendations Status  

Science.gov (United States)

The Planetary Science Division (PSD) within the National Aeronautics and Space Administrations (NASA) Science Mission Directorate (SMD) at NASA Headquarters sought to understand how to better realize a scientific return on spacecraft system technology investments currently being funded. In order to achieve this objective, a team at NASA Glenn Research Center was tasked with surveying the science and mission communities to collect their insight on technology infusion and additionally sought inputs from industry, universities, and other organizations involved with proposing for future PSD missions. This survey was undertaken by issuing a Request for Information (RFI) activity that requested input from the proposing community on present technology infusion efforts. The Technology Infusion Study was initiated in March 2013 with the release of the RFI request. The evaluation team compiled and assessed this input in order to provide PSD with recommendations on how to effectively infuse new spacecraft systems technologies that it develops into future competed missions enabling increased scientific discoveries, lower mission cost, or both. This team is comprised of personnel from the Radioisotope Power Systems (RPS) Program and the In-Space Propulsion Technology (ISPT) Program staff.The RFI survey covered two aspects of technology infusion: 1) General Insight, including: their assessment of barriers to technology infusion as related to infusion approach; technology readiness; information and documentation products; communication; integration considerations; interaction with technology development areas; cost-capped mission areas; risk considerations; system level impacts and implementation; and mission pull. 2) Specific technologies from the most recent PSD Announcements of Opportunities (AOs): The Advanced Stirling Radioisotope Generator (ASRG), aerocapture and aeroshell hardware technologies, the NASA Evolutionary Xenon Thruster (NEXT) ion propulsion system, and the Advanced Materials Bi-propellant Rocket (AMBR) engine.This report will present the teams Findings from the RFI inputs and the recommendations that arose from these findings. Methodologies on the findings and recommendations development are discussed.

Anderson, David J.; Sandifer, Carl E., II; Sarver-Verhey, Timothy R.; Vento, Daniel M.; Zakrajsek, June F.

2014-01-01

107

Drop impact dynamics on oil-infused nanostructured surfaces.  

Science.gov (United States)

We experimentally investigated the impact dynamics of a water drop on oil-infused nanostructured surfaces using high-speed microscopy and scalable metal oxide nano surfaces. The effects of physical properties of the oil and impact velocity on complex fluid dynamics during drop impact were investigated. We show that the oil viscosity does not have significant effects on the maximal spreading radius of the water drop, while it moderately affects the retraction dynamics. The oil viscosity also determines the stability of the infused lubricant oil during the drop impact; i.e., the low viscosity oil layer is easily displaced by the impacting drop, which is manifested by a residual mark on the impact region and earlier initiation of prompt splashing. Also, because of the liquid (water)-liquid (oil) interaction on oil-infused surfaces, various instabilities are developed at the rim during impact under certain conditions, resulting in the flower-like pattern during retraction or elongated filaments during spreading. We believe that our findings will contribute to the rational design of oil-infused surfaces under drop impact conditions by illuminating the complex fluid phenomena on oil-infused surfaces during drop impact. PMID:24976266

Lee, Choongyeop; Kim, Hyunsik; Nam, Youngsuk

2014-07-22

108

The lollipop with strawberry aroma may be promising in reduction of infusion-related nausea and vomiting during the infusion of cryopreserved peripheral blood stem cells.  

Science.gov (United States)

Nausea and vomiting during the infusion of cryopreserved peripheral blood stem cells (PBSC) are common. The aim of this study was to explore the effect of lollipop with strawberry aroma on the infusion-related nausea and vomiting of cryopreserved autologous PBSCs. We compared 2 groups of adult patients receiving lollipop with strawberry aroma during cryopreserved PBSC infusions or not to assess the incidences of nausea and vomiting occurring during infusions. All patients received granisetron 3 mg i.v. twice a day, and lorazepam 1 mg every 4 hours orally for prophylaxis of the nausea and vomiting during conditioning phase and infusion day. Before infusion, all patients were premedicated with pheniramine maleate 45.5 mg i.v. and paracetamol 500 mg orally. The patients had no evidence of nausea or vomiting prior to cryopreserved PBSC infusions. The patients with ongoing nausea or vomiting owing to conditioning regimens and/or receiving additional antiemetics were excluded from the study. One hundred fifty-eight patients who consecutively underwent autologous stem cell transplantation for malignancy were included in the study. The first 110 patients (median age: 42.5, range: 17-75) were observed for the infusion related adverse effects only. The consecutive 48 patients (median age: 48, range: 18-80) were given a lollipop with strawberry aroma during cryopreserved PBSC infusions and observed for the infusion-related adverse effects. The 2 groups were comparable with respect to age, sex, diagnosis, stem cell collection methods, conditioning regimens administered, total mononuclear cell dose infused, number of total nucleated cells (TNCs) infused, number of CD34+ cells infused, number of bags infused, total volume infused, amount of dimethylsulfoxide (DMSO), and infusion rate. Patients who received a lollipop with a strawberry aroma during infusions had significantly less nausea (6.3%, n = 3 versus 21.8%, n = 24, P = .02) and vomiting (2%, n = 1 versus 13.6%, n = 15, P = .04) than the ones who did not (observation only group). Other infusion-related adverse events were as follows; hypoxia, cough, dyspnea, abdominal cramping, tachycardia, hiccup, fever, chills, chest pain, hypotension, hypertension, agitation, sore throat, and arrhythmia. Incidences of each of these adverse events were <5% in both groups and were comparable. The use of a lollipop with a strawberry aroma during infusion of cryopreserved autologous PBSCs may be promising in reduction of infusion-related nausea and vomiting, with an easy administration at a very cheap cost. PMID:19041066

Ozdemir, Evren; Akgedik, Kiymet; Akdogan, Sadiye; Kansu, Emin

2008-12-01

109

Demonstration of the dorsal pancreatic artery by CTA to facilitate superselective arterial infusion of stem cells into the pancreas  

International Nuclear Information System (INIS)

Purpose: To investigate the diagnostic performance of 64-section CTA in the detection of dorsal pancreatic artery before interventional therapy for patients with diabetes. Materials and methods: The study was approved by the institutional ethics committee; written informed consent was obtained. Forty-two consecutive patients with diabetes received an experimental treatment of autologous bone marrow-derived stem cell transplantation by means of infusion into the dorsal pancreatic artery. All cases underwent abdominal CTA before angiography of pancreatic arteries in order to locate the origin and course of dorsal pancreatic artery. Angiography of coeliac artery, splenic artery, common hepatic artery and superior mesenteric artery were performed both in CTA and DSA. Superselective catheterization of dorsal pancreatic artery was carried out for the infusion of stem cell. Sensitivity, specificity and accuracy for the detection of dorsal pancreatic artery with CTA were calculated using DSA images as the reference standard. Results: Thirty-five and thirty-six dorsal pancreatic arteries were detected by CTA and DSA respectively. Dorsal pancreatic artery was not visualized in either CTA or DSA in 5 patients. The sensitivity, specificity and accuracy for CTA were 94.4%, 83.3% and 92.9%. Conclusion: 64-section CTA is accurate for the detection of dorsal pancreatic artery. It may be useful for the facilitation of superselective arterial infusion of stem cells to pancreas.nfusion of stem cells to pancreas.

110

Determination of selected microelements in polish herbs and their infusions  

Energy Technology Data Exchange (ETDEWEB)

Ba, Cd, Cr, Cu, Fe, Ni, Pb and Zn were determined in birch leaves (Folium Betulae), dandelion roots (Radix Taraxacae), hawthorn blossom (Inflorescentia Crataegi) and their infusions by graphite furnace atomic absorption spectrometry (GFAAS) after microwave digestion of plant samples. Infusions were made from herbs according to prescription for patients, provided by the producer of medicine on the package. The results obtained were compared with daily requirements for each element. Results show high content of cadmium in the medicinal plants analyzed. The highest level in infusions was observed for Ni and Zn (over 90% of the total element concentration for Ni and in most cases over 50% for Zn), and the lowest for Cd and Pb. The calculated daily intake of majority of the analyzed elements was very low (under 1% of daily requirements)

Kalny, Piotr [Medical University of Warsaw, Department of Drugs Analysis, Banacha 1, 02-091 Warsaw (Poland); Fijalek, Zbigniew [Medical University of Warsaw, Department of Drugs Analysis, Banacha 1, 02-091 Warsaw (Poland); National Medicines Institute, Department of Pharmaceutical Chemistry, Chelmska 30/34, 00-725 Warsaw (Poland); Daszczuk, Anna [Medical University of Warsaw, Department of Drugs Analysis, Banacha 1, 02-091 Warsaw (Poland); Ostapczuk, Peter [Research Center of Juelich, Department of Safety and Radiation Protection, Leo-Brand Str. 1, D-52425 Juelich (Germany)]. E-mail: p.ostapczuk@fz-juelich.de

2007-08-01

111

Determination of selected microelements in polish herbs and their infusions  

International Nuclear Information System (INIS)

Ba, Cd, Cr, Cu, Fe, Ni, Pb and Zn were determined in birch leaves (Folium Betulae), dandelion roots (Radix Taraxacae), hawthorn blossom (Inflorescentia Crataegi) and their infusions by graphite furnace atomic absorption spectrometry (GFAAS) after microwave digestion of plant samples. Infusions were made from herbs according to prescription for patients, provided by the producer of medicine on the package. The results obtained were compared with daily requirements for each element. Results show high content of cadmium in the medicinal plants analyzed. The highest level in infusions was observed for Ni and Zn (over 90% of the total element concentration for Ni and in most cases over 50% for Zn), and the lowest for Cd and Pb. The calculated daily intake of majority of the analyzed elements was very low (under 1% of daily requirements)

112

Iterating infusion clear views of systems, classes and systems  

CERN Document Server

"Iterating Infusion: Clearer Views of Objects, Classes, and Systems" is a one-of-a-kind book, not dependent on any single technology. Rather, it provides a way to integrate the most efficient techniques from a variety of programming methods, in a manner that makes designing and programming software look easy. "Iterating Infusion" presents comprehensive tools for you to best manage and work with object orientation. These include simplified fundamental concepts, popular language comparisons, advanced designing strategies, a broad usage progression, thorough design notations (interaction algebra), and data-oriented (fundamentally-OO) languages. The title, "Iterating Infusion," alludes to the fact that any system has multiple, coexisting functional levels and that new levels--both lower and higher--are continually added to the same functional area. The practical effect is to bring processes into more focus, always clarifying the vague. The extreme form of this is when separate but compatible technologies are brou...

Anthony, Greg

2005-01-01

113

An experimental study on the influence of infusion speed on the early mechanism of embolic effect of arterially infused absolute Ethanol in the rat  

International Nuclear Information System (INIS)

In order to clarify the early mechanism of action of the tissue necrosis induced by intraarterially infused absolute ethanol, abdominal aortography and histopathologic examination after absolute ethanol infusion into aorta at fast (0.4ml/sec) and slow speed (0.04ml/sec) were performed on 22 rats (2 controls, 7 in fast infusion group, 7 in slow infusion group, 3 in fast and 3 in slow infusion groups during aorta compression, respectively). Histopathologic features under the light and scanning electron microscope were correlated with the angiographic findings within 30 minutes after ethanol infusion. The results are as follows : 1. In fast infusion group, histopathologic examination of the kidney showed severe glomerular and tubular damage. Extensive damage on endothelial and medial layer was noted in arteries, and fresh thrombi originated from the damaged arterial wall were seen. 2. Angiographic findings in the fast infusion group were luminal irregularity and early obstruction of large arteries. And circulation time was prolonged. 3. In slow infusion group, histopathologic examination of the kidney showed focal area of severe glomerular and tubular damage on relatively normal background. Endothelial and muscular damage was noted in arteries, but the degree of the damage was less severe than that of the fast infusion group. 4. Angiographic findings in the slow infusion group were focal perfusion defect of the kidney, delayed circulation time, and mild luminal irregularrculation time, and mild luminal irregularity, but obstruction of the major arteries was not seen

114

Intracoronary ghrelin infusion decreases coronary blood flow in anesthetized pigs.  

Science.gov (United States)

The peptide ghrelin has been linked to the atherosclerotic process and coronary artery disease. We planned to study, for the first time, the primary effects of ghrelin on the intact coronary circulation and determine the mechanisms involved. In 24 sodium pentobarbitone-anesthetized pigs, changes in anterior descending coronary blood flow caused by intracoronary infusion of ghrelin at constant heart rate and arterial pressure were assessed using electromagnetic flowmeters. In 20 pigs, intracoronary infusion of ghrelin decreased coronary blood flow without affecting left ventricular maximum rate of change of left ventricular systolic pressure (dP/dt(max)), filling pressures of the heart or plasma levels of GH. In four pigs, this decrease was graded by step increments of infused dose of the hormone. The mechanisms of the above response were studied in the 20 pigs by repeating the experiment after coronary flow had returned to the control values observed before infusion. The ghrelin-induced coronary vasoconstriction was not affected by iv atropine (five pigs) or phentolamine (five pigs). This response was abolished by iv butoxamine (five pigs) and intracoronary N(omega)-nitro-l-arginine methyl ester (five pigs), even after reversing the increase in arterial pressure and coronary vascular resistance caused by the two blocking agents with iv infusion of papaverine. The present study showed that intracoronary infusion of ghrelin primarily caused coronary vasoconstriction. The mechanisms of this response were shown to involve the inhibition of a vasodilatory beta(2)-adrenergic receptor-mediated effect related to the release of nitric oxide. PMID:17110424

Grossini, Elena; Molinari, Claudio; Mary, David A S G; Ghigo, Ezio; Bona, Gianni; Vacca, Giovanni

2007-02-01

115

A retrospective evaluation of postbreeding infusions in dairy cattle.  

OpenAIRE

Health and fertility data were recorded in 32 southern Ontario Holstein herds over a period of two and a half years. During that time 2.6% (80/3123) of breedings were followed by a postbreeding infusion. Breedings were divided into groups according to the breeding number (first to fifth), age group (less than 3 yr, 3 to 5.9 yr, greater than or equal to 6 yr) and disease status of the reproductive tract (four groups). The rate of use of infusions was higher following third to fifth breedings, ...

Dohoo, I. R.

1984-01-01

116

Cholecystocholangiography via short-term infusion of iodoxamate  

International Nuclear Information System (INIS)

The cholegraphic agent iodoxamate (Endomirabil) was examined in respect of its contrasting perfomance and its side effects in the application form of a short infusion in 141 patients. Besides the global contrasting frequency of the biliary system we determined the connection between contrasting rate and the time post infusionem. Results were compared with data from literature and with those obtained in an own study on the cholegraphic agent iotroxic acid (Biliscopin). If applied via short-term infusion, iodoxamate (Endomirabil) shows advantages over conventional manual injection techniques. Constrasting potency and side effects of iodoxamic acid and iotroxic acid are of the same order of magnitude for both products. (orig.)

117

Radionuclide venography using continuous Kr-81 m infusion: preliminary note  

International Nuclear Information System (INIS)

Continuous infusion of Kr-81m presents important advantages compared to the commonly used radionuclides for venography. High count rates can be accumulated, and a high resolution collimator can be employed to ensure good quality images. The study can be repeated immediately and multiple views can be performed until a satisfactory result is obtained. The production of radionuclide from a Rb-81--Kr-81m generator suitable for intravenous infusion is almost the same as that which is suitable for ventilation. The same generator can first be used for venography and then for ventilation imaging to complete the work-up patients suspected of having thromboembolic disease

118

Melissa officinalis and Passiflora caerulea infusion as physiological stress decreaser  

OpenAIRE

The objective of this study was to determine the effect of a Melissa officinalis and Passiflora caerulea infusion on the severity of physiological chronic stress induced by movement restriction in CF-1 mice. 40 CF-1 male mice, six weeks of age, were divided into 4 groups (n = 10 for each group): (1) Group RS/MP received two treatments, induced stress through movement restriction and a infusion of Melissa officinalis and Passiflora caerulea in a dose of 200 mg/kg, (2) RS group with induced str...

Feliu?-hemmelmann, Karina; Monsalve, Francisco; Rivera, Ce?sar

2013-01-01

119

Hyperinsulinemic euglycemic step clamping with tracer glucose infusion and labeled glucose infusate for assessment of acute insulin resistance in pigs.  

Science.gov (United States)

The present study aimed to establish hyperinsulinemic euglycemic step clamping with tracer glucose infusion and labeled glucose infusate (step hot-GINF HEC) for assessment of acute insulin resistance in anesthetized pigs and to arrange for combination with invasive investigative methods. Tracer enrichment was measured during D-[6,6-(2)H(2)]glucose infusion before and after surgical instrumentation (n = 8). Insulin dose-response characteristics were determined by two step hot-GINF HEC procedures, with accordingly labeled glucose infusates performed at a total of six insulin infusion rates ranging from 0.2 to 2.0 mU kg(-1) min(-1) (n = 8). Finally, three-step hot-GINF HEC (0.4, 1.2, and 2.0 mU kg(-1) min(-1)) was performed subsequent to major surgical trauma (n = 8). Tracer enrichment, basal glucose kinetics, and circulating levels of C-peptide, cortisol, glucagon, and catecholamines were not influenced by surgical instrumentation. Mean intraindividual coefficient of variance levels for glucose infusion rates and repeatedly measured insulin, glucose, and tracer enrichment indicated stable clamping conditions. Basal and maximal insulin-stimulated glucose utilization was twice as high as in humans at approximately 5.5 and 21 mg kg(-1) min(-1). Surgical trauma elicited pronounced peripheral and moderate hepatic insulin unresponsiveness (45% lower whole body glucose disposal and 19% less suppressed endogenous glucose release) and apparently diminished metabolic insulin clearance. Step hot-GINF HEC seems suitable for assessment of acute insulin resistance in anesthetized pigs, and combination with invasive investigative methods requiring surgical instrumentation can be accomplished without the premises for utilization of the technique being altered, but attention must be paid to alterations in metabolic insulin clearance. PMID:20371732

Gjessing, Petter Fosse; Fuskevåg, Ole-Martin; Hagve, Martin; Revhaug, Arthur; Irtun, Øivind

2010-06-01

120

Passive Infusion: A Simple Delivery Method for Retrograde Cardioplegia  

OpenAIRE

Some damage to the capillaries and increase in myocardial edema have been shown when retrograde cardioplegia perfusion pressure exceeds 40–50 mmHg, or possibly when it falls within this pressure interval. To avoid these complications, we designed a very simple delivery method for retrograde cardioplegia: passive continuous infusion by gravitational force alone.

Yilik, Levent; Ozsoyler, Ibrahim; Yakut, Necmettin; Emrecan, Bilgin; Yasa, Haydar; Calli, Aylin Orgen; Gurbuz, Ali

2004-01-01

121

Curriculum Infusion as College Student Mental Health Promotion Strategy  

Science.gov (United States)

This article describes efforts to increase faculty involvement in suicide prevention and mental health promotion via curriculum infusion. The participants were faculty, staff, and 659 students enrolled in classes of a large eastern university from Fall 2007-Spring 2011. Counselors, health educators, and medical providers recruited faculty from a…

Mitchell, Sharon L.; Darrow, Sherri A.; Haggerty, Melinda; Neill, Thomas; Carvalho, Amana; Uschold, Carissa

2012-01-01

122

Targeting chemotherapy via arterial infusion for advanced gastric cancer  

Directory of Open Access Journals (Sweden)

Full Text Available Objective To evaluate the clinical effects of chemotherapy via arterial infusion in treatment of advanced gastric cancer.Methods Forty-seven patients with advanced gastric cancer were given chemotherapy via arterial infusion.Chemotherapy plan was as follows: 5-Fluorouracil(Fu 500mg/m2,cyclophosphamide(MMX 10mg/m2,Hydroxycamptothecin(HPT 20mg/m2,once per week,2 weeks as a course,a total of 2-3 courses.Results After chemotherapy via arterial infusion,complete remission(CR was achieved in 1 case,partial remission(PR in 28 cases,stabilization of disease(SD in 16 cases,progression of disease(PD was found in 2 cases,and rate with response(CR+PR was 61.7%.Four of 28 PR patients underwent tumorectomy,the pathology revealed the presence of cancer cells around the vascular vessels,manifesting karyopyknosis,karyorrhexis,coagulation and necrosis of cytoplasm,intercellular edema,hyperplasia of fibroblasts,inflammatory cell infiltration,thickening of endothelium,and thrombosis.One,two and three-year survival rates were 70.2%,14.9% and 2.1%,respectively.The average survival period was 17.2 months.Conclusion Targeting chemotherapy via arterial infusion,as a part of the combined treatment,is beneficial to the patients with unresectable advanced gastric cancer.

Zhi-yu CAO

2011-10-01

123

Technique and diagnostic utility of saline infusion sonohysterography.  

Science.gov (United States)

The introduction of saline infusion sonohysterography has significantly improved sonographic diagnosis of various endometrial pathologies. This procedure entails instillation of warm saline into the uterine cavity transcervically to provide enhanced visualization of the endometrium during transvaginal ultrasound examination. This article reviews the sonohysterography technique and current utility, as well as the spectrum of imaging features of various endometrial pathologies. PMID:19232599

Elsayes, Khaled M; Pandya, Amit; Platt, Joel F; Bude, Ronald O

2009-04-01

124

Doing Business with China: Curriculum Internationalisation through an Infusion Method  

Science.gov (United States)

The US apparel and textiles industry operates within an interdependent global system, necessitating workforces competent for day-to-day operations. The US workforce lacks preparedness in working globally; this study tests an infusion method of curriculum internationalisation to enhance students' global understanding. Four cognitive and…

Jin, Byoungho; Swinney, Jane; Cao, Huantian; Muske, Glenn; Nam, Jinhee; Kang, Ji Hye

2011-01-01

125

Melissa officinalis and Passiflora caerulea infusion as physiological stress decreaser.  

Science.gov (United States)

The objective of this study was to determine the effect of a Melissa officinalis and Passiflora caerulea infusion on the severity of physiological chronic stress induced by movement restriction in CF-1 mice. 40 CF-1 male mice, six weeks of age, were divided into 4 groups (n = 10 for each group): (1) Group RS/MP received two treatments, induced stress through movement restriction and a infusion of Melissa officinalis and Passiflora caerulea in a dose of 200 mg/kg, (2) RS group with induced stress using movement restriction, (3) MP group, which received only a infusion, and (4) a CONTROL group that received no treatment. The severity of the stress was obtained by analysis of the physical parameters of body weight, thymus and spleen, and associated biomarkers with stress, corticosterone, and glucose. Animals that consumed Melissa officinalis and Passiflora caerulea infusion had lower plasma corticosterone levels (Student's t test, Welch, p = 0.05), which is the most important biomarker associated with physiological stress, demonstrating a phytotherapy effect. PMID:23844268

Feliú-Hemmelmann, Karina; Monsalve, Francisco; Rivera, César

2013-01-01

126

Modern Methods of Infusion Therapy in Patients with Shock  

Directory of Open Access Journals (Sweden)

Full Text Available The aim of the investigation is the assessment of the effect of various variant of infusion therapy on the function of organs and systems of patients with hemorrhagic and traumatic shock. Materials and methods. There have been presented the results of the single-blind prospective cohort randomized study (by envelope technique of 219 patients with hemorrhagic and traumatic shock divided into group depending on infusion therapy variant. Results. The use of 6% hydroxyethylated starch colloid solution 200/0.5 in infusion therapy program in patients with II–III degree hemorrhagic and traumatic shock was stated not to contribute to effective correction of hypovolemia and systemic hemodynamicss as well as have the negative effect on hemostasis that causes the severity of multiple organ failure. Meanwhile, the use of 4% oxypolygelatin in these patients appeared to correct systemic hemodynamics and not to contribute to severe organ dysfunctions. The use of balanced crystalloid solution of sterofundin isotonic in contrast to imbalanced solution of normal saline has a positive effect on electrolyte and acid-base composition of blood plasma in infusion therapy of patients with II–III degree hemorrhagic and traumatic shock.

?.?. Girsh

2012-08-01

127

Arts-Infused Learning in Middle Level Classrooms  

Science.gov (United States)

To address arts education disparities in middle level schools, this paper explores evidence that infusing the visual and performing arts into language arts, math, science, and history/social studies courses is a pedagogical approach that meets the developmental needs of early adolescents and fosters a relevant, challenging, integrative, and…

Lorimer, Maureen Reilly

2011-01-01

128

Prostacyclin infusion may prevent secondary damage in pericontusional brain tissue  

DEFF Research Database (Denmark)

Prostacyclin is a potent vasodilator, inhibitor of leukocyte adhesion, and platelet aggregation, and has been suggested as therapy for cerebral ischemia. A case of focal traumatic brain lesion that was monitored using intracerebral microdialysis, and bedside analysis and display is reported here. When biochemical signs of cerebral ischemia progressed, i.v. infusion of prostacyclin was started.

Reinstrup, Peter; Nordström, Carl-Henrik

2011-01-01

129

Treatment of bladder carcinoma with concomitant infusion chemotherapy and irradiation  

International Nuclear Information System (INIS)

In an attempt to increase tumor clearance and bladder preservation without increased morbidity, a pilot study using irradiation and concomitant continuous 5-FU infusion, and Mitomycin C as IV bolus in the treatment of invasive high grade bladder carcinomas was started at Downstate Medical Center. This report shows the preliminary results regarding tumor response, survival, and morbidity of treatment

130

Infusing Research into Teacher Education: Ideas for Practice.  

Science.gov (United States)

A process for infusing clinical supervision research findings into teacher education programs was implemented at Indiana University of Pennsylvania. The major goal of the program was to improve the clinical practice of supervision from both the public school faculty perspective and the university supervisor role. A planned seminar series assisted…

Ryan, Charles W.; Butzow, John W.

131

The value of MR enteroclysis with air infusion in the diagnosis of small bowel disease  

International Nuclear Information System (INIS)

Objective: To investigate the value of MR enteroclysis with air infusion in the diagnosis of small bowel disease. Methods: Sixteen patients with suspected small bowel disease, but without acute inflammatory disease or bowel obstruction, received MR enteroclysis with air infusion. There were 12 males and 4 females, and their age ranged from 17 to 75 years. 10 patients had abdominal pain, 4 with melena or blood stool, and 2 with diarrhea. The longest course was 7 years, and the shortest 1 week. Before MR imaging, a nasoenteric catheter was inserted into the distal part of duodenum, and about 1000 ml of air was infused through the tube to distend the small bowel. 20 mg of IV anisodamine was given to reduce small-bowel peristalsis. All patients were imaged with fat-saturated Gd-DTPA enhanced coronal and axial T1-weighted spin-echo (SE) sequence and fast spoiled gradient echo (FSPGR) sequence. Comparison between the diagnosis of MRI and the results of surgery, pathology or clinic was performed to assess the sensitivity and specificity of MRI. Results: 5 cases were normal, 6 with Crohn disease, 2 with gastric intestinal stromal tumor (GIST), and 1 each of lymphoma, tuberculosis and irritable bowel syndrome. The lumen of normal small bowel in MR enteroclysis was no signal, the wall was outlined as middle signal by intraluminal air and surrounding air-distended bowel and was between 1-3 mm thick, and the diameter of the lumen was between 17-28 mm. Crohn disease shoen was between 17-28 mm. Crohn disease showed segmental mural thickening, increased enhancement, luminal stricture, and even extraluminal inflammatory mass or fistula. Intestinal tuberculosis invaded the distal section of ileum, cecum, and the proximal ascending colon, the wall thickened and enhanced apparently, and cecum and proximal ascending colon shortened. GIST showed a mass that was iso-signal on T1WI, high signal on T2WI, and enhanced significantly after IV Gd-DTPA. 1 recurrent lymphoma of ileum showed mural thickening and increased enhancement but no stenosis. 1 irritable bowel syndrome is disfunction, so its shape and signal is normal. Except 1 Crohn disease, which showed a large mass, was misdiagnosed as lymphoma and no abnormality was found in 1 irritable bowel syndrome, the other diagnosis of MRI was correct. The sensitivity in diagnosing small intestinal disease was 100%, and the specificity was 83%. Conclusion: MR enteroclysis with air infusion is a sensitive method in diagnosing the small bowel disease, especially in Crohn disease and tumor. It can clearly display the mural thickening and the extraluminal inflammatory mass

132

Cesarean Sections  

Science.gov (United States)

... babies in the United States are delivered via cesarean section (C-section). Even if you're envisioning a ... have a successful and safe vaginal birth after cesarean but, in some cases, future births may have to be C-sections, especially if the incision on the uterus was ...

133

Study of Cisatracurium and Sufentanil Consumption Using a Closed Loop Computer Control Infusion System  

Science.gov (United States)

The Intraoperative Effect of Dexmedetomidine on Cisatracurium Infusion Consumption and Its Recovery Index.; Effect of Dexmedetomidine on Sufentanil Consumption.; Quantitative Analysis of Cisatracurium Infusion Requirements, Sufentanil Consumption and Recovery Index in Different Age Groups.

2013-02-06

134

Effects of intravenous delivery systems on infused red blood cells.  

Science.gov (United States)

The effects of various intravenous delivery systems on the integrity of infused red blood cells (RBCs) were studied. Using a factorial design, whole blood and packed RBCs were infused through i.v. delivery systems employing various combinations of i.v. tubing diameter and length, needle gauge, infusion rate (5 and 50 ml/hr), type of infusion pump (piston, diaphragm, or peristaltic operation), and type of blood product. The age and temperature of the blood filter used were held constant. A 5-ml sample of the blood product obtained during each experimental run was analyzed for plasma free-hemoglobin to assess the degree of hemolysis. Osmotic fragility of the RBCs was evaluated by measuring the percentage of hemolysis in the blood products in various concentrations of sodium chloride solution. Type of blood product and i.v. pump were the only variables significantly influencing RBC hemolysis. In both blood products, a greater degree of hemolysis occurred with the peristaltic-type pump than with the other types of pumps. In packed RBCs, the diaphragm-type pump produced greater hemolysis than the piston-type pump, but hemolysis was similar in whole-blood samples. Regardless of the type of pump, more hemolysis occurred in whole blood at the 5-ml/hr infusion rate than at the 50-ml/hr rate, but the converse was true in packed RBCs. Samples of both blood products were less osmotically fragile than their respective controls at sodium chloride concentrations ranging from 0.30 to 0.50%.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:6702849

Gibson, J S; Leff, R D; Roberts, R J

1984-03-01

135

Utilization of rapid-infuser devices for massive blood loss.  

Science.gov (United States)

Rapid volume replacement for severe hemorrhage continues to challenge the clinician involved in the care of the patient suffering hemorrhagic shock. We report on the development and utilization of two rapid-infuser systems for volume replacement in critically ill patients presenting in extremis. We have developed rapid-infusion circuits by using commercially available devices available at our institution. The primary pumping mechanism is either a centrifugal pump (Revolution--COBE Cardiovascular, Arvada, CO, USA), or the Myocardial Protection System (MPS Quest Medical, Allen, TX, USA), and offers advantages over commercially available devices. Both circuits consist of a cardiotomy reservoir, a cardioplegia delivery set, assorted tubing and connectors, and a heater-cooler system. Between January and October of 2003, 15 procedures were performed which utilized one of these two devices. There were nine ruptured aneurysms, five traumas and one radical nephrectomy. The rapid infusion time averaged 228.5 +/- 105.7 min where 10.4 +/- 9.4 L of autotransfusion volume was processed, with 3.9 +/- 4.2 L of red cell volume reinfused. The allogeneic blood products that were transfused included packed red blood cells and fresh frozen plasma, as well as 5% albumin. There were no intraoperative deaths and the rapid-infuser was considered lifesaving in all instances. Mechanical rapid infusion systems may be lifesaving when severe hypovolemia or hemorrhagic shock is encountered. While both devices are able to meet the requirements of rapid fluid replacement, the MPS offers the most safety features and has become the standard of care at our institution. PMID:15918442

Stammers, Alfred H; Murdock, James D; Klayman, Myra H; Trowbridge, Cody; Yen, Bianca R; Franklin, David; Elmore, James

2005-03-01

136

[Polycyclic aromatic hydrocarbons in tea and tea infusions].  

Science.gov (United States)

Tea is the one of most widely consumed beverage in the world. It is generally believed that tea consumption might have health promoting properties. But residues of certain chemical compounds might impose a health threat on tea drinkers. The main contaminants are heavy metals, fluoride, pesticides and even dioxins. Tea lives which possess a high surface area can be contaminated with atmospheric PAHs. The manufacturing processes may also introduce PAHs into tea lives. The aim of his study was to determine the contamination of black, green, red and white teas by PAHs. In this investigation, content of 23 PAH, i.e 16 EPA PAH and 15 EU PAH were determined in 18 brands of tea and its infusions. The analytical procedure was based on ultrasonic extraction for dried tea and liquid-liquid extraction for infusions. All samples were cleaned up by florisil cartridge. The total content of 23 PAH varied between 22.9 microg/kg to 2945.5 microg/kg and 2.7 microg/kg to 63,1 microg/kg microg/kg for BaP. The analysed tea samples showed an increasing presence of PAH in the following order (mean value): black tea < red tea < green tea < white tea. However the highest content of PAH was found in the one brand of black tea bag both in sum of PAH and BaP content. During tea infusion 1.6% of total PAHs contained in tea was released into the beverage. The dominant PAHs in tea infusion were 2, 3 and 4 rings PAH, while the most toxic compounds were found at trace amounts. The concentrations of total 23 PAHs and BaP in tea infusions ranged from 332.5 ng/dm3 to 2245.9 ng/dm3 and 0.35 ng/dm3 to 18.7 ng/dm3 respectively. PMID:21365858

Ciemniak, Artur; Mocek, Kamila

2010-01-01

137

Successful rechallenge of cetuximab following severe infusion-related reactions: a case report  

OpenAIRE

Cetuximab, an anti-epidermal growth factor receptor (EGFR) monoclonal antibody, is associated with a risk of infusion reactions, similar to other infusional agents. Although avoiding a rechallenge with cetuximab following a severe infusion reaction is preferable, this may not be an option if few other reasonable alternatives exist. We report herein a successful case of cetuximab rechallenge, carried out by extending infusion times and using saline dilution in a patient who had severe infusion...

Chang, Pei-hung; Huang, Jen-seng

2014-01-01

138

Regulation of iodothyronine deiodinase activity as studied in thyroidectomized rats infused with thyroxine or triiodothyronine  

OpenAIRE

To provide new insights into the in vivo regulation of iodothyronine deiodinases in the different tissues of the rat, we have evaluated the effects on these enzymatic activities of T4 or T3 infusions into thyroidectomized rats. Thyroidectomized rats were infused with placebo, T4, or T3. Placebo-infused intact rats served as euthyroid controls. Plasma and samples of cerebral cortex, brown adipose tissue, pituitary, liver, and lung were obtained after 12-13 days of infusion. Plasma TSH, plasma ...

Escobar-morreale, He?ctor F.; Obrego?n, Mari?a Jesu?s; Herna?ndez, Arturo; Escobar Del Rey, Francisco; Morreale Escobar, Gabriella

1997-01-01

139

Continuous versus Intermittent Infusions of Ceftazidime for Treating Exacerbation of Cystic Fibrosis?  

OpenAIRE

The present multicenter, randomized crossover study compared the safety and efficacy of continuous infusion with those of short infusions of ceftazidime in patients with cystic fibrosis. Patients with chronic Pseudomonas aeruginosa colonization received two successive courses of intravenous tobramycin and ceftazidime (200 mg/kg of body weight/day) for pulmonary exacerbation administered as thrice-daily short infusions or as a continuous infusion. The primary endpoint was the variation in the ...

Hubert, Dominique; Le Roux, Evelyne; Lavrut, Thibaud; Wallaert, Benoit; Scheid, Philippe; Manach, Dominique; Grenet, Dominique; Sermet-gaudelus, Isabelle; Ramel, Sophie; Cracowski, Claire; Sardet, Anne; Wizla, Nathalie; Deneuville, Eric; Garraffo, Rodolphe

2009-01-01

140

Infusion pressure and pain during microneedle injection into skin of human subjects  

OpenAIRE

Infusion into skin using hollow microneedles offers an attractive alternative to hypodermic needle injections. However, the fluid mechanics and pain associated with injection into skin using a microneedle have not been studied in detail before. Here, we report on the effect of microneedle insertion depth into skin, partial needle retraction, fluid infusion flow rate and the co-administration of hyaluronidase on infusion pressure during microneedle-based saline infusion, as well as on associat...

Gupta, Jyoti; Park, Sohyun; Bondy, Brian; Felner, Eric I.; Prausnitz, Mark R.

2011-01-01

141

Mineral Analysis the Infusion of Black Tea Samples by Atomic Absorption Spectrometry  

OpenAIRE

Tea infusion is one of the most popular drinks around the world. Since tea infusion is known to contain several essential nutrients, it is considered a healthy beverage. In this study eight different Iranian brands of tea infusion and eleven brands imported tea infusion samples from another country for Cu, Zn, Mn and Al were determined by flame atomic absorption spectrometry after wet digestion. The results of analysis showed that the extraction rates of minerals from dry black tea to infusio...

Lahiji N.; Tadayon F.; Tamiji F.; Lahiji A. H.

2013-01-01

142

Using miniature osmotic infusion pumps to maintain tritiated thymidine exposure to cells in culture  

International Nuclear Information System (INIS)

To provide a constant level of tracer doses of tritiated thymidine to cultured cells during continuous infusion, miniature osmotic infusion pumps were used to provide replacement thymidine. By determining the loss of isotope from the media during nonreplacement, the rate of constant infusion replacement to maintain thymidine levels was calculated. The replacement rates were similar for the three cell lines examined and allowed a standard osmotic pump infusion

143

Haemolysis following rapid experimental red blood cell transfusion--an evaluation of two infusion pumps  

DEFF Research Database (Denmark)

The vast majority of infusion pumps used for rapid transfusion of large amounts of blood have never been properly examined regarding their influence on the quality of the red blood cells (RBCs) infused. In this study, we evaluated the effect of two different infusion pumps on the degree of RBC destruction following rapid experimental blood transfusion.

Hansen, Tom Giedsing; SprogØe-Jakobsen, U

1998-01-01

144

Long-term intraarterial chemotherapy infusion of ambulatory head and neck cancer patients.  

Science.gov (United States)

The complications of percutaneous intraarterial infusion chemotherapy of the head-and-neck-cancer patient has dampened enthusiasm for this approach. A totally implantable infusion pump system circumvents many of these complications and will in the long term enhance the opportunity to expand upon the advantages of infusion chemotherapy for the benefit of all cancer patients. PMID:6290790

Baker, S R; Wheeler, R H

1982-10-01

145

Glucose Infusion into Exercising Dogs after Confinement: Rectal and Active Muscle Temperatures  

Science.gov (United States)

Intravenous glucose infusion into ambulatory dogs results in attenuation of exercise-induced increase of both rectal and thigh muscle temperatures. That glucose (Glu) infusion attenuates excessive increase in body temperature from restricted activity during confinement deconditioning. Intravenous glucose infusion attenuates the rise in exercise core temperature in deconditioned dogs by a yet undefined mechanism.

Greenleaf, J. E.; Kruk, B.; Nazar, K.; Falecka-Wieczorek, I.; Kaciuba-Uscilko, H.

1995-01-01

146

Mannitol infusion immediately after reperfusion suppresses the development of focal cortical infarction after temporary cerebral ischemia in gerbils.  

Science.gov (United States)

Previously we found that, after temporary cerebral ischemia, microvasculogenic secondary focal cerebral cortical ischemia occurred, caused by microvascular obstruction due to compression by swollen astrocytic end-feet, resulting in focal infarction. Herein, we examined whether mannitol infusion immediately after restoration of blood flow could protect the cerebral cortex against the development of such an infarction. If so, the infusion of mannitol might improve the results of vascular reperfusion therapy. We selected stroke-positive animals during the first 10?min after left carotid occlusion performed twice with a 5-h interval, and allocated them into four groups: sham-operated control, no-treatment, mannitol-infusion, and saline-infusion groups. Light- and electron-microscopic studies were performed on cerebral cortices of coronal sections prepared at the chiasmatic level, where the focal infarction develops abruptly in the area where disseminated selective neuronal necrosis is maturing. Measurements were performed to determine the following: (A) infarct size in HE-stained specimens from all groups at 72 and 120 h after return of blood flow; (B) number of carbon-black-suspension-perfused microvessels in the control and at 0.5, 3, 5, 8, 12 and 24 h in the no-treatment and mannitol-infusion groups; (C) area of astrocytic end-feet; and (D) number of mitochondria in the astrocytic end-feet in electron microscopic pictures taken at 5?h. The average decimal fraction area ratio of infarct size in the mannitol group was significantly reduced at 72 and 120?h, associated with an increased decimal fraction number ratio of carbon-black-suspension-perfused microvessels at 3, 5 and 8?h, and a marked reduction in the size of the end-feet at 5 h. Mannitol infusion performed immediately after restitution of blood flow following temporary cerebral ischemia remarkably reduced the size of the cerebral cortical focal infarction by decreasing the swelling of the end-feet, thus preventing the microvascular compression and stasis and thereby microvasculogenic secondary focal cerebral ischemia. PMID:24661099

Ito, Umeo; Hakamata, Yoji; Watabe, Kazuhiko; Oyanagi, Kiyomitsu

2014-08-01

147

Liquid Resin Infusion process monitoring with embedded superimposed long period and short period Bragg grating sensor.  

Directory of Open Access Journals (Sweden)

Full Text Available We propose here the monitoring of the Liquid Resin Infusion (LRI process for using a superimposed long period (LPG and short period (FBG Bragg grating sensor. Monitoring of such a process is usually made measuring simultaneously temperature and strain by the use of an electro-optical device (FBG-Thermocouple. It has been shown that an applied solicitation is measured by a wavelength shift with a different sensitivity for LPG and FBG; thus strain and temperature influences can be determined separately by measuring corresponding wavelength shifts. The reported configuration is based on the use of these two Bragg gratings types written in the same fibre section, which allows us to discriminate the contributions of the temperature and strain. The sensor is embedded in a composite specimen manufactured by LRI process for monitoring in real time and simultaneously the applied temperature and strain.

Robert L.

2010-06-01

148

Studies on the subcommissural organ area in the rat: the effects aldosterone infused into the central nervous system  

International Nuclear Information System (INIS)

D-aldosterone (5 ng/?l/hr) was infused for six days into the area of the subcommissural organ (SCO) of conscious rats to test the hypothesis that the SCO and the adrenal zona glomerulosa are related functionally in a negative feedback manner. Aldosterone increased urinary sodium loss and the sodium/potassium ratio. These effects still occurred when cannulae were displaced caudally up to 1 mm from the targeted SCO area. Aldosterone decreased the cross-sectional area of the adrenal medulla without affecting chromaffin cell density. Adrenal content of corticosterone was increased. These effects were highly dependent upon proper cannula placement and were not observed when the tip of the cannula was not in contact with the cerebrospinal fluid of the pineal recess over the rostral two-thirds of the SCO. Aldosterone infused intracerebroventricularly (ivt) into a lateral ventricle had no effect on sodium excretion, adrenal corticosterone concentration or adrenal morphology. After the infusion of radiolabelled aldosterone into the SCO area, the majority of the radioactivity was restricted to an area about 1-2 mm in diameter from the SCO. Iron-dextran injected intraperiotoneally did not accumulate in the SCO; therefore, the blood-brain barrier is intact. It is concluded that the effects of aldosterone were dependent upon the area of the brain in which it was infused. Aldosterone increased sodium excretion by an action in the SCO and/or adjacent structures. A relationship between mineralocorticoids and the adrenal modulla mediated by the SCO is also postulated. With regard to the blood-brain and brain-CSF barriers, the SCO more closely resembles general brain tissue than other circumventricular organs

149

Delivery after caesarean section: review of 2176 consecutive cases.  

OpenAIRE

A total of 2176 consecutive patients who had had one previous caesarean section were studied retrospectively. A repeat elective caesarean section was performed in 395 (18.2%). Labour started spontaneously in 1363 patients, 301 of whom were given oxytocin to accelerate inert labour, and was induced by amniotomy and infusion of oxytocin in 418 women; 1618 of these 1781 patients (90.8%) delivered vaginally. Patients who had had a previous vaginal delivery were more likely to deliver vaginally ag...

Molloy, B. G.; Sheil, O.; Duignan, N. M.

1987-01-01

150

Geophysical control of water infusion into rock strata for reducing rock burst hazards  

Energy Technology Data Exchange (ETDEWEB)

Presented is a review of seismic, geoelectric, seismoacoustic and microseismic methods for control of water infusion used for rock burst prevention in Poland. The seismic method consists in measuring propagation of transverse or longitudinal waves before and after water infusion into a coal seam. The CS-4G seismic detection system (made in Poland) is used. Geoelectric method consists in determining effects of water infusion on electric conductivity of coal. The Terrameter system made by the ABEM company (Sweden) is used. Seismoacoustic monitoring supplies valuable information on dynamics of fissure formation in coal and rock strata during water infusion. The reviewed control methods are used in the Wujek mine for assessment of water infusion efficiency. Conditions of water infusion such as borehole dimensions and distribution, water pressure, and infusion time are described. Evaluation results are shown in 8 schemes and diagrams. On the basis of experiments carried out in the Wujek mine criteria for assessment of water infusion efficiency are determined. Three classes are used: extremely efficient water infusion, efficient infusion, and water infusion with low efficiency. 6 references.

Dubinski, J.; Szot, M.

1983-07-01

151

Rapid infusion with rituximab: short term safety in systemic autoimmune diseases  

DEFF Research Database (Denmark)

To describe the incidence, types and severity of adverse events, related to an accelerated regime of rituximab infusion in patients with various autoimmune diseases. Fifty-four patients with systemic autoimmune disease, to be treated with 1,000 mg of rituximab twice 2 weeks apart, participated. Pre-medication (oral prednisolone, anti-histamine and paracetamol) was administered 1-4 h before infusion start. The first infusion was administered over a period of 195 min. The second infusion over a period of 90 min. Any adverse events were classified using the Clinical Trials Classification of Adverse Events (CTCAE) v. 3.0. Ten patients (18.5%) experienced at least one infusion-related reaction (IRR) ever. The first infusion was associated with reactions in 4 CTCAE categories of which rhinitis were the most frequent. The CTCAE severity grading showed six patients (11.1%) had a grade 1 reaction. One patient (1.8%) had grade 2 events on both infusions and two patients (3.6%) had a grade 3 event on both infusions. RA patients more often had an infusion-related reaction (IRR) (9.2%) than the rest. The types of IRR were mostly of allergic or angio-oedematic nature. In practise, the rapid infusion was an easy to use regime and the second infusion is of time sparing significance to health professionals. No unexpected side effects were observed in relation to the accelerated regime.

Larsen, Janni Lisander; Jacobsen, Soren

2013-01-01

152

Rare, potentially fatal, poorly understood propofol infusion syndrome  

Directory of Open Access Journals (Sweden)

Full Text Available We present the case of a 7-year old boy with traumatic brain injury who received propofol during 38 h. Thirty-six hours after cessation of propofol infusion asystole occurred. After immediate mechanical and medical resuscitation, unreactive dilated pupils were observed. The following computed tomography scan revealed a generalized brain edema with transtentorial herniation. Prolonged bradyarrhythmia, rhabdomyolysis, and peracute renal failure were observed. Despite immediate craniectomy, barbiturate treatment, hemofiltration, and recovery of appropriate cardiac function, the patient died four days after discontinuation of propofol. In this case, metabolic acidosis, cardiac failure, rhabdomyolysis, and renal failure are in accordance with the symptoms of propofol infusion syndrome (PRIS, while seizure, brain edema, and transtentorial herniation could be caused by traumatic brain injury. However, it may be assumed that the entire clinical picture was caused by PRIS. This view could be explained by a common loss of function of ryanodine receptors in patients presenting with PRIS.

Albert Urwyler

2012-05-01

153

Infusing Disability Sport into the Sport Management Curriculum  

Directory of Open Access Journals (Sweden)

Full Text Available Disability sport is growing around the world with momentum and is described as a “movement” (Bailey, 2008; DePauw & Gavron, 2005. While there are more similarities than differences with sport management for able-bodied athletes and those with disabilities, there are additional needs and considerations for persons with disabilities (DePauw & Gavron, 2005. The noticeable visibility of individuals with disabilities in society, including sport, raises concerns about the degree to which sport management academic programs have modified their curricula to ensure that individuals working in the sport management field are prepared to deal with theuniqueness of disability sport. This paper (a discusses theoretical perspectives toward understanding and thinking about disability, (b explores ways to enhance sport management curricula through infusion of disability sport, (c reflects upon current social practices for curriculum integration of athletes with disabilities in sport, and (d acknowledges infusion of disability sport businesses, organizations and events.

Jimmy Calloway

2012-01-01

154

Smart Infusion Pump: A boon to the Health Care Industry  

Directory of Open Access Journals (Sweden)

Full Text Available Main motive of any hospital or clinic is to provide the best patient care. Patient care can be drastically improved using electronic medical record. An electronic medical record (EMR is a computerized medical record created in an organization that delivers care, such as a hospital or physician's office. The costs of storage media, such as paper and film, per unit of information differ dramatically from that of electronic storage media. When paper records are stored in different locations, collating them to a single location for review by a health care provider is time consuming and complicated, whereas the process can be simplified with electronic records. When treating a patient another major thing is to monitor the drug or fluid administered to the patient. Better and safer drug delivery systems will be the one with automatic or an intelligent infusion pump system. Thus automatic intravenous infusion will efficiently reduce medication and administration error.

K.V. Padmaja#1 , Apoorva M. Kalgal

2013-06-01

155

Oviposition responses of Culex tarsalis and Culex quinquefasciatus to aged Bermuda grass infusions.  

Science.gov (United States)

Fermented infusions of organic matter are commonly used as baits in traps for gravid female mosquitoes. However, infusions are dynamic, and their effects on mosquito oviposition as their chemical and microbial constituents change over time are not well documented. Bermuda grass infusion fermented for periods of 0-63 days was stimulatory to gravid Culex quinquefasciatus. In contrast, only 5-25-day-old infusion was stimulatory to Culex tarsalis. Standard-aged infusion (7 days old) was as effective or better than infusion of any other age for Cx. tarsalis, whereas Cx. quinquefasciatus exhibited a distinct preference for 2-4-wk-old infusion. The results are discussed in terms of mosquito species' oviposition site preferences and in terms of mosquito surveillance programs. PMID:7616188

Isoe, J; Beehler, J W; Millar, J G; Mulla, M S

1995-03-01

156

Somatostatin infusion enhances hepatic glucose production during hyperglucagonemia.  

Science.gov (United States)

Somatostatin (SRIH) is widely employed in metabolic studies to permit quantitation of glucose production and disposal rates while the endocrine pancreas is suppressed and the hormonal milieu is under the investigator's control. In these studies it is assumed that if peripheral levels of insulin and glucagon are the same during SRIH infusion as during control studies, the effects of these hormones on glucose metabolism are equivalent. If the effect of glucagon is influenced by SRIH infusion, then these techniques may be unsuitable for the study of the regulation of hepatic glucose output. To assess the influence of SRIH on glucagon-stimulated hepatic glucose production (Ra), we determined Ra during paired studies in ten healthy (five younger and five older) subjects. In each study an insulin infusion designed to yield physiologic systemic insulin levels of 20 to 30 microU/mL was given from 0 to 210 minutes. In addition, from 60 to 210 minutes either glucagon alone (3.5 ng/kg/min) (I + IRG) or glucagon (3.5 ng/kg/min) and SRIH (250 micrograms/h) (I + IRG + SRIH) was infused. Since results for plasma levels of insulin, C-peptide, glucagon, and Ra were similar in young and old subjects, the two age groups were combined for analysis. Basal plasma insulin, glucagon, C-peptide, glucose, and Ra were similar in each arm of the study. Insulin values were nearly identical from 60 to 210 minutes (I + IRG, 23.8 +/- 1.1; I + IRG + SRIH, 24.0 +/- 1.0 microU/mL).(ABSTRACT TRUNCATED AT 250 WORDS) PMID:2893970

Meneilly, G S; Minaker, K L; Elahi, D; Rowe, J W

1988-03-01

157

Hepatic Arterial Infusion Chemotherapy for Advanced Hepatocellular Carcinoma in Japan  

OpenAIRE

Transcatheter methods such as transcatheter arterial chemoembolization (TACE) and hepatic arterial infusion chemotherapy (HAIC) have an important role in the treatment for advanced hepatocellular carcinoma (HCC). Recently, sorafenib, an inhibitor of tyrosine kinases, has been found to obtain survival benefits in patients with HCC, leading to major advances in the treatment of advanced HCC. However, it is associated with a low tumor response rate, minimal survival advantage, and high rates of ...

Ryuichi Kita; Toru Kimura; Hiroki Nishikawa; Yukio Osaki

2012-01-01

158

Continuous infusion of doxorubicin, epirubicin and mitoxantrone in cancer chemotherapy  

OpenAIRE

Most types of metastatic solid tumors cannot be cured by the available chemotherapeutic agents. Although this failure is often a result of intrinsic or acquired drug resistance, ineffective drug dosage or scheduling may contribute to treatment inefficacy. The therapeutic index of drugs may be improved by modifying the delivery schedule, such as expanding the infusion time, in order to increase the exposure of metabolically active tumor cells to the drug and simultaneously decrease toxicicty b...

Greidanus, Janke

1988-01-01

159

Continuous infusion of methylene blue for septic shock.  

OpenAIRE

Nitric oxide has been determined to be a potential mediator of the haemodynamic changes associated with sepsis. The haemodynamic eects of nitric oxide can be partially antagonised by methylene blue, through inhibition of the enzyme, guanylate cyclase. The case report presented here demonstrates a beneficial haemodynamic eect of continuous infusion of methylene blue during sepsis. These findings could be extrapolated to other patients or prompt additional research.

Brown, G.; Frankl, D.; Phang, T.

1996-01-01

160

Metabolism of ifosfamide during a 3 day infusion.  

OpenAIRE

Urinary drug metabolites were measured in 21 patients receiving ifosfamide by continuous infusion over 3 days. Mean values for the proportion of drug excreted as parent compound, 2-dechloroethylifosfamide (2-DC), 3-dechloroethylifosfamide (3-DC), carboxyifosfamide (CX) and ifosforamide mustard (IPM) were 19, 6, 10, 7 and 8% of dose respectively. The proportion of urinary drug products in the form of ifosfamide fell considerably over the course of the 3 days. This was mirrored by an increase i...

Hartley, J. M.; Hansen, L.; Harland, S. J.; Nicholson, P. W.; Pasini, F.; Souhami, R. L.

1994-01-01

161

The analgesic and sedative properties of dexmedetomidine infusion after uvulopalatopharyngoplasty  

OpenAIRE

Background: Dexmedetomidine is an alpha2 - adrenergic agonist with sedative and analgesic properties. This study aimed to investigate if the use of continuous dexmedetomidine infusion with i.v. morphine patient-controlled analgesia (PCA) could improve postoperative analgesia while reducing opioid consumption and opioid-related side effects. Materials & methods: In this prospective randomized, double-blinded, controlled study, 24 patients with obstructive sleep apnea syndrome undergoing uvulop...

Nassar, W. Abd El Megid ¹. And Ahmed M.

2009-01-01

162

Liquid infused porous surfaces for mineral fouling mitigation.  

Science.gov (United States)

Prevention of mineral fouling, known as scale, is a long-standing problem in a wide variety of industrial applications, such as oil production, water treatment, and many others. The build-up of inorganic scale such as calcium carbonate on surfaces and facilities is undesirable as it can result in safety risks and associated flow assurance issues. To date the overwhelming amount of research has mainly focused on chemical inhibition of scale bulk precipitation and little attention has been paid to deposition onto surfaces. The development of novel more environmentally-friendly strategies to control mineral fouling will most probably necessitate a multifunctional approach including surface engineering. In this study, we demonstrate that liquid infused porous surfaces provide an appealing strategy for surface modification to reduce mineral scale deposition. Microporous polypyrrole (PPy) coatings were fabricated onto stainless steel substrates by electrodeposition in potentiostatic mode. Subsequent infusion of low surface energy lubricants (fluorinated oil Fluorinert FC-70 and ionic liquid 1-Butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide (BMIm)) into the porous coatings results in liquid-repellent slippery surfaces. To assess their ability to reduce surface scaling the coatings were subjected to a calcium carbonate scaling environment and the scale on the surface was quantified using Inductively Coupled Plasma Atomic Emission Spectroscopy (ICP-AES). PPy surfaces infused with BMIm (and Fluorinert to a lesser extent) exhibit remarkable antifouling properties with the calcium carbonate deposition reduced by 18 times in comparison to untreated stainless steel. These scaling tests suggest a correlation between the stability of the liquid infused surfaces in artificial brines and fouling reduction efficiency. The current work shows the great potential of such novel coatings for the management of mineral scale fouling. PMID:25585291

Charpentier, Thibaut V J; Neville, Anne; Baudin, Sophie; Smith, Margaret J; Euvrard, Myriam; Bell, Ashley; Wang, Chun; Barker, Richard

2015-04-15

163

The calcaneum as a site for intraosseous infusion.  

OpenAIRE

Intraosseous infusion has been recommended as a rapid and effective form of circulatory access in the collapsed child. Recognised sites for insertion include the tibia, femur, iliac crest, sternum, and clavicle. The case of a 3 year old collapsed child is described who was successfully resuscitated with the use of an intraosseous needle placed in the calcaneum; the method of needle insertion is also detailed.

Mccarthy, G.; Buss, P.

1998-01-01

164

Efficacy of hepatic arterial infusion chemotherapy in advanced hepatocellular carcinoma  

OpenAIRE

AIM: To investigate the efficacy of hepatic arterial infusion chemotherapy (HAIC) using floxuridine (FUDR) in patients with advanced hepatocellular carcinoma (HCC) confined to the liver. METHODS: Thirty-four patients who had advanced HCC with unresectability or unsuccessful previous therapy in the absence of extrahepatic metastasis were treated with intra-arterial FUDR chemotherapy at our hospital between March 2005 and May 2008. Among the 34 patients, 9 patients were classified as Child clas...

Yang Hyun Baek; Kyoung Tae Kim; Sung Wook Lee; Jin Sook Jeong; Byeong Ho Park; Kyung Jin Nam; Jin Han Cho; Young Hoon Kim; Young Hoon Roh; Hyung Sik Lee; Young Min Choi; Sang Young Han

2012-01-01

165

Understanding Infusion Administration in the ICU through Distributed Cognition  

OpenAIRE

To understand how healthcare technologies are used in practice and evaluate them, researchers have argued for adopting the theoretical framework of Distributed Cognition (DC). This paper describes the methods and results of a study in which a DC methodology, Distributed Cognition for Teamwork (DiCoT), was applied to study the use of infusion pumps by nurses in an Intensive Care Unit (ICU). Data was gathered through ethnographic observations and interviews. Data analysis consisted of construct...

Rajkomar, A.; Blandford, A. E.

2012-01-01

166

Saline infusion sonohysterography versus hysteroscopy for uterine cavity evaluation  

OpenAIRE

Background and Objectives: The most frequent procedures performed on women with abnormal uterine bleeding are 2D and 3D ultrasound. The most common accepted approach for the management of abnormal uterine bleeding is 2D TV scan followed by therapeutic hysteroscopy. The purpose of this prospective study was to assess whether 3D saline infusion sonohysterography (3D SIS) could replace diagnostic hysteroscopy (DH) for the diagnosis of endometrial pathology, in patients with abnormal uteri...

Khan Faryal; Jamaat Sadia; Al-Jaroudi Dania

2011-01-01

167

Combined infusion cholecystography in patients with the postgastroresection syndromes  

International Nuclear Information System (INIS)

Using a combined infusion cholecystography in patients with postgastroresection syndromes, the concentration, motor-evacuator function of the biliary bladder and changes in biliary tracts are studied. 71 patients (63 men and 8 women) in the age of 31-65 have been investigated. It is shown that in patients who have suffered resection, the interaction of motor-evacuator function of the gastrointestinal tract.and biliary tracts is upset which can further lead to profound pathologic changes in these organs

168

Sustained resveratrol infusion increases natriuresis independent of renal vasodilation.  

Science.gov (United States)

Resveratrol is reported to exert cardio-renal protective effects in animal models of pathology, yet the mechanisms underlying these effects are poorly understood. Previously, we reported an i.v. bolus of resveratrol induces renal vasodilation by increasing nitric oxide bioavailability and inhibiting reactive oxygen species. Thus, we hypothesized a sustained infusion of resveratrol would also increase renal blood flow (RBF), and additionally glomerular filtration rate (GFR). We infused vehicle for 30 min followed by 30 min resveratrol at either: 0, 0.5, 1.0, 1.5 mg/min, and measured RBF, renal vascular resistance (RVR), GFR, and urinary sodium excretion. At all three doses, blood pressure and GFR remained unchanged. Control RBF was 7.69 ± 0.84 mL/min/gkw and remained unchanged by 0.5 mg/min resveratrol (7.88 ± 0.94 mL/min/gkw, n = 9), but urinary sodium excretion increased from 2.19 ± 1.1 to 5.07 ± 0.92 ?mol/min/gkw (n = 7, P RBF by 17%, from 7.16 ± 0.29 to 8.35 ± 0.42 mL/min/gkw (P RBF 12% from 6.76 ± 0.57 to 7.58 ± 0.60 mL/min/gkw (n = 8, P < 0.003), decreased RVR 15% (15.58 ± 1.35 to 13.27 ± 1.14 ARU, P < 0.003) and increased sodium excretion (3.99 ± 1.71 to 7.80 ± 1.51 ?mol/min/gkw, n = 8, P < 0.04). We conclude that a constant infusion of resveratrol can induce significant renal vasodilation while not altering GFR or blood pressure. Also, resveratrol infusion produced significant natriuresis at all doses, suggesting it may have a direct effect on renal tubular sodium handling independent of renal perfusion pressure or flow. PMID:25214522

Gordish, Kevin L; Beierwaltes, William H

2014-09-01

169

Impaired bacteriological responses in babies after maternal iron dextran infusion.  

OpenAIRE

The effect of a total dose infusion of iron dextran in pregnancy on 15 mothers and their babies was compared with 19 controls. The bacteriostatic effect and opsonising ability of the sera, of babies born to the treated mothers, were considerably impaired. This was associated with a significantly lower transferrin concentration in these mothers. Although these in vitro tests were not associated with an increase in overt infection during the perinatal period, they suggest the need for caution i...

Webster, M. H.; Waitkins, S. A.; Stott, A.

1981-01-01

170

Reactive hypoglycaemia following GLP-1 infusion in pancreas transplant recipients  

OpenAIRE

The aim of the study was to determine whether reactive hypoglycaemia in pancreas transplant recipients that followed administration of glucagon-like peptide-1 (GLP-1) was associated with excessive insulin, insufficient glucagon, or both. Methodology involved six portally drained pancreas recipients who received GLP-1 (1.5 pmol/kg/min) or placebo infusion on randomized occasions during glucose-potentiated arginine testing. The second subject developed symptomatic hypoglycaemia [plasma glucose ...

Rickels, M. R.; Naji, A.

2010-01-01

171

A Successful Infusion Process for Enabling Lunar Exploration Technologies  

Science.gov (United States)

The NASA Vision for Space Exploration begins with a more reliable flight capability to the International Space Station and ends with sending humans to Mars. An important stepping stone on the path to Mars encompasses human missions to the Moon. There is little doubt throughout the stakeholder community that new technologies will be required to enable this Vision. However, there are many factors that influence the ability to successfully infuse any technology including the technical risk, requirement and development schedule maturity, and, funds available. This paper focuses on effective infusion processes that have been used recently for the technologies in development for the lunar exploration flight program, Constellation. Recent successes with Constellation customers are highlighted for the Exploration Technology Development Program (ETDP) Projects managed by NASA Glenn Research Center (GRC). Following an overview of the technical context of both the flight program and the technology capability mapping, the process is described for how to effectively build an integrated technology infusion plan. The process starts with a sound risk development plan and is completed with an integrated project plan, including content, schedule and cost. In reality, the available resources for this development are going to change over time, necessitating some level of iteration in the planning. However, the driving process is based on the initial risk assessment, which changes only when the overall architecture changes, enabling some level of stability in the process.

Over, Ann P.; Klem, Mark K.; Motil, Susan M.

2008-01-01

172

Zoledronic acid infusion for prevention and treatment of osteoporosis.  

Science.gov (United States)

Osteoporotic fractures are associated with significant morbidity, reduced quality of life, increased mortality, and high health care costs. Bisphosphonates are standard therapy for treatment of osteoporosis. However, patient compliance and persistence with oral weekly or monthly bisphosphonate therapy are suboptimal and may lead to reduced effectiveness. Zoledronic acid (ZOL) is an intravenous bisphosphonate that is given once yearly for the treatment of osteoporosis via a medically supervised 15-minute infusion. This ensures compliance for a full 12 months. In clinical trials, an annual infusion of ZOL 5 mg has shown sustained efficacy in reducing hip and spine fractures in postmenopausal women with osteoporosis. It has also been shown to increase bone density in postmenopausal women with osteopenia (low bone mass) and in men with osteoporosis. Transient flu-like symptoms are the most common adverse effects following ZOL infusion, and these can generally be managed with acetaminophen. The availability of an intravenous bisphosphonate that ensures compliance over a long dosing interval may help to overcome barriers to efficacy resulting from poor long-term compliance with oral agents. PMID:21151682

Sunyecz, John A

2010-01-01

173

Infusion of docosahexaenoic acid protects against myocardial infarction.  

Science.gov (United States)

Most of the cardioprotective effects of long-chain omega 3 fatty acids, namely docosahexaenoic (DHA; 22:6n-3) and eicosapentaenoic (EPA; 20:5n-3), are due to their hypotriglyceridemic and anti-inflammatory effects, which lower the risk for cardiovascular disease and myocardial infarction. Little is known on the direct preventive activities of DHA and EPA on heart function. In isolated hearts, we studied (1) whether infused DHA is able to protect the heart from ischemia/reperfusion damage and (2) the role played by Notch-mediated signal transduction pathways in myocardial infarction. Perfusion with DHA before and before/after induction of ischemia reperfusion significantly diminished cardiac damage and afforded antioxidant protection. Mechanistically, infusion of DHA before and before/after the induction of ischemia differentially modulated the expression of Notch2 and 3 target genes. In particular, DHA increased the expression of Hey1 when infused pre- and pre/post-ischemia; Jagged 1 and the Notch2 receptors increased with DHA pre-ischemia, but not pre/post; Notch2 and 3 receptors as well as Delta increased following DHA administration pre- and (especially) pre/post-ischemia. In conclusion, while the precise nature of the Notch-mediated protection from ischemia/reperfusion afforded by DHA is as yet to be fully elucidated, our data add to the growing body of literature that indicates how systemic administration of DHA provides cardiovascular protection. PMID:24480264

Richard, D; Oszust, F; Guillaume, C; Millart, H; Laurent-Maquin, D; Brou, C; Bausero, P; Visioli, F

2014-04-01

174

Regional blood flow during continuous low-dose endotoxin infusion  

International Nuclear Information System (INIS)

Escherichia coli endotoxin (ET) was administered to adult rats by continuous IV infusion from a subcutaneously implanted osmotic pump (Alzet). Cardiac output and regional blood flow were determined by the radiolabeled microsphere method after 6 and 30 hr of ET or saline infusion. Cardiac output (CO) of ET rats was not different from time-matched controls, whereas arterial pressure was 13% lower after 30 hr of infusion. After both 6 and 30 hr of ET, pancreatic blood flow and percentage of cardiac output were lower than in controls. Estimated portal venous flow was decreased at each time point, and an increased hepatic arterial flow (significant after 30 hr) resulted in an unchanged total hepatic blood flow. Blood flow to most other tissues, including epididymal fat, muscle, kidneys, adrenals, and gastrointestinal tract, was similar between treatments. Maintenance of blood flow to metabolically important tissues indicates that the previously reported alterations in in vitro cellular metabolism are not due to tissue hypoperfusion. Earlier observations of in vitro myocardial dysfunction, coexistent with the significant impairment in pancreatic flow, raise the possibility that release of a myocardial depressant factor occurs not only in profound shock but also under less severe conditions of sepsis and endotoxemia

175

Zoledronic acid infusion for prevention and treatment of osteoporosis  

Directory of Open Access Journals (Sweden)

Full Text Available John A SunyeczLaurel Highlands Ob/Gyn, Hopwood, Pennsylvania, USA and MenopauseRx, Inc., Uniontown, PA, USAAbstract: Osteoporotic fractures are associated with significant morbidity, reduced quality of life, increased mortality, and high health care costs. Bisphosphonates are standard therapy for treatment of osteoporosis. However, patient compliance and persistence with oral weekly or monthly bisphosphonate therapy are suboptimal and may lead to reduced effectiveness. Zoledronic acid (ZOL is an intravenous bisphosphonate that is given once yearly for the treatment of osteoporosis via a medically supervised 15-minute infusion. This ensures compliance for a full 12 months. In clinical trials, an annual infusion of ZOL 5 mg has shown sustained efficacy in reducing hip and spine fractures in postmenopausal women with osteoporosis. It has also been shown to increase bone density in postmenopausal women with osteopenia (low bone mass and in men with osteoporosis. Transient flu-like symptoms are the most common adverse effects following ZOL infusion, and these can generally be managed with acetaminophen. The availability of an intravenous bisphosphonate that ensures compliance over a long dosing interval may help to overcome barriers to efficacy resulting from poor long-term compliance with oral agents.Keywords: fractures, intravenous bisphosphonate, osteoporosis, zoledronic acid

John A Sunyecz

2010-10-01

176

Fat overload syndrome after the rapid infusion of SMOFlipid emulsion.  

Science.gov (United States)

Fat overload syndrome is a well-known complication of intravenous lipid emulsion therapy. It is characterized by headaches, fever, jaundice, hepatosplenomegaly, respiratory distress, and spontaneous hemorrhage. Other symptoms include anemia, leukopenia, thrombocytopenia, low fibrinogen levels, and coagulopathy. Several reports in the literature describe fat overload syndrome caused by rapid infusion of lipid emulsions, all with soybean-based lipid emulsions. We report fat overload syndrome in a 2-year-old girl with short bowel syndrome on home parenteral nutrition. Fat overload syndrome occurred as a result of accidental, very rapid infusion of a 20% soy oil, medium-chain triglyceride, olive and fish oil-based lipid emulsion (SMOFlipid) that showed the same complications seen with an earlier lipid emulsion (Intralipid). The patient was successfully treated with supportive care combining fluid infusion, transfusion of platelets, and substitution of serum albumin (0.5 g/kg/d) and fresh-frozen plasma (10 mL/kg). In the next couple of days, she received extra platelets, erythrocyte transfusion, and filgrastim (Neupogen; 5 µg/kg/d) due to a very low leukocyte count. To the best of our knowledge, this is the first case of fat overload syndrome caused by SMOFlipid emulsion described in the literature. PMID:23520135

Hojsak, Iva; Kola?ek, Sanja

2014-01-01

177

Double balloon device compared to oxytocin for induction of labour after previous caesarean section  

Directory of Open Access Journals (Sweden)

Full Text Available Objective: To assess cervical changes, duration of oxytocin infusion, mode of delivery and complications after cervical ripening using a double balloon device in women with a previous caesarean section. Methods: Longitudinal study including 80 women with a previous caesarean section, no previous vaginal delivery and an unfavourable cervix (Bishop score

José García-Adanez

2013-02-01

178

Preliminary results of a randomized study of intrahepatic infusion versus systemic infusion of FUDR for metastatic colorectal carcinoma  

International Nuclear Information System (INIS)

This paper presents a randomized study that compares intrahepatic infusion to systemic infusion applying the same chemotherapeutic agent (FUDR), schedule, and method of administration. Radiation therapy patients with measurable metastatic colorectal carcinoma to the liver, without extrahepatic disease, are eligible. Patients with a Karnofsky Performance Status less than 60% and a serum bilirubin greater than 4.0 mg/d1 are excluded. To date, 11 partial responses (PR's) in 26 evaluable patients were seen in the intrahepatic group and 8 PR's in 24 evaluable patients in the systemic group. The median duration of response is 7 months for both groups. There were two minor responses in each group. In the systemic group, 3 patients have stable disease for 4-13+ months. Fifteen patients in the intrahepatic group and 10 patients in the systemic group have had more than 50% reduction in carcinoembryonic antigen level

179

Intracoronary ghrelin infusion decreases coronary blood flow in aneIntracoronary ghrelin infusion decreases coronary blood flow in anesthetized pigs  

OpenAIRE

The peptide ghrelin has been linked to the atherosclerotic process and coronary artery disease. We planned to study, for the first time, the primary effects of ghrelin on the intact coronary circulation and determine the mechanisms involved. In 24 sodium pentobarbitone-anesthetized pigs, changes in anterior descending coronary blood flow caused by intracoronary infusion of ghrelin at constant heart rate and arterial pressure were assessed using electromagnetic flowmeters. In 20 pigs, intracor...

Ghigo, Ezio

2007-01-01

180

Scanning Electron Microscopy of the Endometrium of Mares Infused with Gentamicin  

Science.gov (United States)

Scanning electron microscopy (SEM) was used to study the endometrium of nine 1-year-old thoroughbred mares after twice intrauterine infusions of gentamicin, on 2 consecutive days. Five mares were infused on 2 consecutive days with 40 ml gentamicin (50 mg/ml) mixed with 80 ml of normal saline. Four mares served as controls and were infused with 120 ml of saline on 2 consecutive days. Endometrial biopsies were obtained from all mares 3 days after the second intrauterine infusion. Each biopsy was processed for SEM by standard methods. The endometrial epithelium of the gentamicin-infused mares had more cellular perforations than the saline-infused mares. The gentamicin-infused mares had less and shorter microvilli. The ciliated cells were fewer and some ciliated cells had disrupted and some had drooping cilia. The endometrial epithelium of the gentamicin-infused mares had a considerable number of endometrial cells that lost their luminal surfaces and some that lost their microvilli, compared to the saline-infused mares. We suggest that the information gathered in this pilot study should be used as basis for further investigation, on a larger scale basis, of the effects of repeated intrauterine infusion of gentamicin on the endometrial mucosa of mares.

Al-Bagdadi, F. K.; Eilts, B. E.; Richardson, G. F.

2004-04-01

181

Clinical assessment of first pass radionuclide ventriculography after dipyridamole infusion in patients with coronary artery disease  

International Nuclear Information System (INIS)

First pass radionuclide ventriculography (RNV) was performed after dipyridamole (D) infusion in 33 patients with coronary artery disease (CAD) and 15 normal volunteers. RNV findings after D infusion were compared with those of conventional exercise RNV and body surface ECG mapping (MAP). For patients with multiple vessel disease, left ventricular ejection fraction (LVEF) was significantly lower after D infusion than at rest. Wall motion abnormality (WMA) sites induced by D infusion were well coincident with those induced by exercise. Pressure rate product at exercise was significantly higher than that after D infusion, suggesting the different mechanism of the occurrence of WMA after D infusion and at exercise. The incidence of ischemic reaction tended to be higher after D infusion than at exercise in 25 patients with CAD. There was negative correlation between ST depression on MAP after D infusion and LVEF on RNV after D infusion. This RNV after D infusion can be used as a supplement tool to conventional exercise RNV in the evaluation of the degree of coronary artery lesions and preserved left ventricular function. (Namekawa, K.)

182

Investigation on the pancreatic and stomach secretion in pigs by means of continuous infusion of 14C-amino acids  

International Nuclear Information System (INIS)

2 pigs received a barley-soya bean meal diet and another 2 a casein-wheat starch diet. The specific radioactivity (SR = dpm/?mol) of leucine and phenylalanine in the TCA soluble fraction of plasma and in the TCA soluble and TCA precipitable fractions of pancreatic juice and of digesta leaving the stomach was determined during 6 hours of intravenous infusion of 14C-leucine and 14C-phenylalanine. At the end of the infusion the SR of both amino acids in both fractions of several tissues was measured and used for calculations of the rate of tissue protein synthesis. The results are that mainly amino acids derived from the extracellular space were used for synthesis that the process of synthesis, concentration and secretion of secretory proteins requires in pigs 120 to 180 minutes, and that TCA soluble amino acids in pancreatic juice are not free amino acids per se, but originate from processing of presecretory proteins. In the duodenal digesta labelled proteins appeared 3 to 4 hours after the beginning of the infusion. Both, secretion of proteins by the pancreas and by the stomach seemed to be more stimulated after feeding the barley-soya diet than the casein-starch diet. Of all tissues, the SR of amino acids in proteins was highest in the pancreas. However, proteins secreted by the pancreas were 3 to 4 times higher labelled than those retained in the tissue. The range of the fractional rate of protein synthesis was calculated for the sections of thsis was calculated for the sections of the gastrointestinal tract, the liver and skeletal muscles and discussed with other findings. (author)

183

Continuous versus Intermittent Infusions of Ceftazidime for Treating Exacerbation of Cystic Fibrosis?  

Science.gov (United States)

The present multicenter, randomized crossover study compared the safety and efficacy of continuous infusion with those of short infusions of ceftazidime in patients with cystic fibrosis. Patients with chronic Pseudomonas aeruginosa colonization received two successive courses of intravenous tobramycin and ceftazidime (200 mg/kg of body weight/day) for pulmonary exacerbation administered as thrice-daily short infusions or as a continuous infusion. The primary endpoint was the variation in the forced expiratory volume in 1 s (FEV1) during the course of antibiotic treatment. Sixty-nine of the 70 patients enrolled in the study received at least one course of antibiotic treatment. The improvement in FEV1 at the end of therapy was not statistically different between the two treatment procedures (+7.6% after continuous infusion and +5.5% after short infusions) but was better after continuous ceftazidime treatment in patients harboring resistant isolates (P < 0.05). The interval between the course of antibiotic treatments was longer after the continuous infusion than after the short infusion of ceftazidime (P = 0.04). The mean serum ceftazidime concentration during the continuous infusion was 56.2 ± 23.2 ?g/ml; the mean peak and trough concentrations during the short infusions were 216.3 ± 71.5 and 12.1 ± 8.7 ?g/ml, respectively. The susceptibility profiles of the P. aeruginosa isolates remained unchanged and were similar for both regimens. Quality-of-life scores were similar whatever the treatment procedure, but 82% of the patients preferred the continuous-infusion regimen. Adverse events were not significantly different between the two regimens. In conclusion, the continuous infusion of ceftazidime did not increase its toxicity and appeared to be as efficient as short infusions in patients with cystic fibrosis as a whole, but it gave better results in patients harboring resistant isolates of P. aeruginosa. PMID:19528265

Hubert, Dominique; Le Roux, Evelyne; Lavrut, Thibaud; Wallaert, Benoit; Scheid, Philippe; Manach, Dominique; Grenet, Dominique; Sermet-Gaudelus, Isabelle; Ramel, Sophie; Cracowski, Claire; Sardet, Anne; Wizla, Nathalie; Deneuville, Eric; Garraffo, Rodolphe

2009-01-01

184

Carotid artery mixing with diastole-phased pulsed drug infusion  

International Nuclear Information System (INIS)

Focal injury to the brain or retina is a frequent complication of drug delivery to the internal carotid artery (ICA) and may be due to poor mixing of the drug with blood at the infusion site. Rhesus monkeys were studied to determine whether phased drug delivery during diastole from a modified pulsatile angiographic injector would improve drug mixing in vivo. A radiolabeled flow tracer, carbon-14-iodoantipyrine (14C-IAP), was injected into the ICA of three monkeys in 80-msec pulses, each ending at least 50 msec before the end of local diastole. Local isotope concentration in the brain was determined by quantitative autoradiography. The ratio of highest to lowest concentration was 1.86 +/- 0.26 (mean +/- standard deviation) in the frontoparietal cortex, 1.65 +/- 0.42 in the frontoparietal white matter, 1.89 +/- 0.28 in the temporal cortex, and 1.39 +/- 0.17 in the basal ganglia. These results were similar to recordings in three control animals that received intravenous 14C-IAP to demonstrate complete drug mixing (1.37 +/- 0.12, 1.41 +/- 0.11, 1.70 +/- 0.08, 1.22 +/- 0.24, respectively), and contrasted to findings in five animals which received continuous intracarotid infusions to demonstrate standard ICA drug delivery (4.54 +/- 2.07, 2.94 +/- 1.45, 5.43 +/- 3.57, 3.60 +/- 2.90, respectively). Pulsed intra-arterial infusion during diastole provides a technically simple method for improving intravascular drug mixing, and results in drug delivery to t mixing, and results in drug delivery to tissue capillaries that is proportional to blood flow

185

Digital subtraction angiography of inferior gluteal artery through the infusion catheter of chemotherapy for bladder cancer  

International Nuclear Information System (INIS)

More than fifty patients of invasive bladder cancer had been treated by selective intra-arterial chemotherapy through the inferior or superior gluteal arteries. The distribution of infused drugs had been evaluated by RI-angiography through a thin arterial infusion catheter. This time we performed digital subtraction angiography (DSA) through an infusion catheter in order to know the precise distribution of infused materials in seven patients with locally advanced bladder cancer. Pharmaco-DSA with norepinephrine was also done in four patients. Satisfactory spatial and contrast resolution were gained in four patients and pharmaco-DSA showed better quality. In our experience DSA through intra-arterial infusion catheter was a useful procedure in the evaluation of distribution of infused drugs. (author)

186

The use of intraosseous infusions in the operating room.  

Science.gov (United States)

The use of an intraosseous (IO) infusion during the anesthetic care of an 8-month-old, 5.4-kg infant with cyanotic congenital heart disease (CHD) is presented. Previous vascular access had resulted in thrombotic occlusion of the upper and lower venous systems. When intravenous access could not be achieved, an IO needle was placed and IO access was used during the surgical procedure. The role of the IO route in the perioperative period is discussed and its adverse effect profile is reviewed. PMID:18929292

Joseph, Gayatri; Tobias, Joseph D

2008-09-01

187

Creating an IPE infusion plan: from foundation to implementation.  

Science.gov (United States)

Today's health care system has embraced the model of collaborative interprofessional efforts among health care professionals to achieve desired patient health outcomes. The Academy can offer the foundational experiences needed to support and develop interprofessional patient-centered plans of care for health professional students. This paper explores one institution's approach to the creation of an infusion plan which the authors have termed a "structured immersion approach" (SIA) to interprofessional education (IPE). The SIA supports "Core Signature IPE" experiences within existing silo-based curriculums that allow for interprofessional education experiences and the appreciation of the importance of interprofessional practice in today's health care. PMID:24925042

Pinto Zipp, Genevieve; Maher, Catherine; LaFountaine, Michael; Rizzolo, Denise; Dayalu, Vikram; Goeckel, Carolyn; Torcivia, Elizabeth; Phillips, H James

2014-01-01

188

NASA In-Space Propulsion Technologies and Their Infusion Potential  

Science.gov (United States)

The In-Space Propulsion Technology (ISPT) program has been developing in-space propulsion technologies that will enable or enhance NASA robotic science missions. The ISPT program is currently developing technology in four areas that include Propulsion System Technologies (Electric and Chemical), Entry Vehicle Technologies (Aerocapture and Earth entry vehicles), Spacecraft Bus and Sample Return Propulsion Technologies (components and ascent vehicles), and Systems/Mission Analysis. Three technologies are ready for flight infusion: 1) the high-temperature Advanced Material Bipropellant Rocket (AMBR) engine providing higher performance; 2) NASA s Evolutionary Xenon Thruster (NEXT) ion propulsion system, a 0.6-7 kW throttle-able gridded ion system; and 3) Aerocapture technology development with investments in a family of thermal protection system (TPS) materials and structures; guidance, navigation, and control (GN&C) models of blunt-body rigid aeroshells; and aerothermal effect models. Two component technologies that will be ready for flight infusion in the near future will be Advanced Xenon Flow Control System, and ultra-lightweight propellant tank technologies. Future focuses for ISPT are sample return missions and other spacecraft bus technologies like: 1) Mars Ascent Vehicles (MAV); 2) multi-mission technologies for Earth Entry Vehicles (MMEEV) for sample return missions; and 3) electric propulsion for sample return and low cost missions. These technologies are more vehicle-focused, and present a different set of technology infusion challenges. While the Systems/Mission Analysis area is focused on developing tools and assessing the application of propulsion technologies to a wide variety of mission concepts. These in-space propulsion technologies are applicable, and potentially enabling for future NASA Discovery, New Frontiers, and sample return missions currently under consideration, as well as having broad applicability to potential Flagship missions. This paper provides a brief overview of the ISPT program, describing the development status and technology infusion readiness of in-space propulsion technologies in the areas of electric propulsion, aerocapture, Earth entry vehicles, propulsion components, Mars ascent vehicle, and mission/systems analysis.

Anderson, David; Munk, Michelle; Pencil, Eric; Dankanich, John; Glaab, Lou; Peterson, Todd; Vento, Dan

2012-01-01

189

Wave motions in unbounded poroelastic solids infused with compressible fluids  

CERN Document Server

Looking at rational solid-fluid mixture theories in the context of their biomechanical perspectives, this work aims at proposing a two-scale constitutive theory of a poroelastic solid infused with an inviscid compressible fluid. The propagation of steady-state harmonic plane waves in unbounded media is investigated in both cases of unconstrained solid-fluid mixtures and fluid-saturated poroelastic solids. Relevant effects on the resulting characteristic speed of longitudinal and transverse elastic waves, due to the constitutive parameters introduced, are finally highlighted and discussed.

Quiligotti, S; dell'Isola, F

2010-01-01

190

Propofol infusion rate does not affect local pain on injection.  

OpenAIRE

BACKGROUND: Local pain at the site of an i.v. injection of propofol is a well-known problem, particularly in infants. This randomised investigator-blinded crossover study was designed to assess the effect of the i.v. bolus infusion rate on propofol-induced pain at the site of injection. METHODS: Thirty unpremedicated patients scheduled for ear-nose-throat or plastic surgery at Malmö University Hospital, Sweden, were given two consecutive 2.0 ml injections of propofol 10 mg/ml (Diprivan, Astr...

Grauers, A.; Liljeroth, Elisabeth; A?keson, Jonas

2002-01-01

191

Rectus sheath catheter infusions for post-operative pain management.  

Science.gov (United States)

Managing pain following major abdominal surgery remains a challenge. Traditionally, patient-controlled analgesia (PCA) or epidural analgesia have been used, which have improved post-operative pain and the patient experience, but have presented some problems in recovery. PCA can cause adverse effects, including sedation, nausea, vomiting, and prolonged gastric ileus. While epidurals do have some advantages over PCA, there are risks involved related to catheter insertion and adverse effects, such as hypotension and motor blocks which limit mobility. This article examines rectus sheath catheter infusions, a relatively new and alternative technique to epidural analgesia, and presents some early audit data related to pain scores, analgesic use and mobility. PMID:24938982

Layzell, Mandy

2014-06-24

192

The Case for Infusing Quantitative Literacy into Introductory Geoscience Courses  

Directory of Open Access Journals (Sweden)

Full Text Available We present the case for introductory geoscience courses as model venues for increasing the quantitative literacy (QL of large numbers of the college-educated population. The geosciences provide meaningful context for a number of fundamental mathematical concepts that are revisited several times in a single course. Using some best practices from the mathematics education community surrounding problem solving, calculus reform, pre-college mathematics and five geoscience/math workshops, geoscience and mathematics faculty have identified five pedagogical ideas to increase the QL of the students who populate introductory geoscience courses. These five ideas include techniques such as: place mathematical concepts in context, use multiple representations, use technology appropriately, work in groups, and do multiple-day, in-depth problems that place quantitative skills in multiple contexts. We discuss the pedagogical underpinnings of these five ideas and illustrate some ways that the geosciences represent ideal places to use these techniques. However, the inclusion of QL in introductory courses is often met with resistance at all levels. Faculty who wish to include quantitative content must use creative means to break down barriers of public perception of geoscience as qualitative, administrative worry that enrollments will drop and faculty resistance to change. Novel ways to infuse QL into geoscience classrooms include use of web-based resources, shadow courses, setting clear expectations, and promoting quantitative geoscience to the general public. In order to help faculty increase the QL of geoscience students, a community-built faculty-centered web resource (Teaching Quantitative Skills in the Geosciences houses multiple examples that implement the five best practices of QL throughout the geoscience curriculum. We direct faculty to three portions of the web resource: Teaching Quantitative Literacy, QL activities, and the 2006 workshop website - Infusing Quantitative Literacy into Introductory Geoscience Courses. These portions of the website are designed to give geoscience faculty the resources they need to infuse quantitative content into their entry-level courses, thereby building the QL of the students who enroll. The infusion of QL in the introductory geoscience classroom allows faculty to realistically represent the quantitative nature of the science to the students who may need it most. Ultimately, the inclusion of pedagogically sound quantitative activities and exercises will serve to increase QL of our educated citizenry.

Jennifer M. Wenner

2009-01-01

193

Successful retreatment with infliximab in patients with prior severe infusion reactions.  

Science.gov (United States)

Infusion of the antitumor necrosis factor-alpha chimeric monoclonal antibody infliximab can be associated with the development of severe infusion reactions (IR) during retreatment. We present the case of two rheumatoid arthritis patients with a history of severe acute IR to infliximab who subsequently underwent successful infusion using a prophylactic treatment with a combination of H1 and H2 receptor blockers, hydrocortisone, and diphenhydramine. PMID:16211336

Uthman, Imad; Touma, Zahi; El-Sayyad, Jinane; Zaitoun, Fares

2006-07-01

194

Severe Infusion Reactions to Fabry Enzyme Replacement Therapy: Rechallenge After Tracheostomy  

OpenAIRE

A 34-year-old male patient with Fabry disease (OMIM 301500) commenced enzyme replacement therapy (ERT) with Agalsidase alfa, with positive clinical response. Infusion reactions, initially mild and easily managed, commenced during his 13th infusion, and continued over the next 3 years. Severity of reactions subsequently increased despite very slow infusion, extended prophylactic medication and attempted desensitisation, requiring regular intensive care unit (ICU) admissions. Facial oedema and ...

Nicholls, K.; Bleasel, K.; Becker, G.

2012-01-01

195

Motor Stepper Berbasis Mikrokontroller ATMega 8535 Pada Perancangan Sistem Kendali Otomatis Tetesan Cairan Infus Pada Pasien.  

OpenAIRE

The function infuse which is to give intravenous fluids to patients on a regular basis Mistakes in giving intra venous fluids may be detrimental to the patient, also if there are problems with blockage or running out of liquids if not immediately addressed would be dangerous for patients. Infuse the current user is still manually where mistakes – mistakes such as these are still common, there fore we make an infusion control device design that can work automatically and digit...

Nugraha, Arie Yudha

2011-01-01

196

Morphology and functional responses of isolated inner adrenocortical cells of rats infuse with interleukin-B  

OpenAIRE

The effects of the prolon Ye d infusion with interleukin-1B (IL-10) (20 pM.kg- .min- ') on the function and morphology of the isolated inner cells of the rat adrenal cortex were investigated. After 3 and 5 days of IL-1B infusion, the level of circulating ACTH was below the control level, while the plasma concentration of corticosterone was strikingly elevated. After 5 days of infusion, isolated inner adrenocortical cells showed an enhanced basal and ACTH-stimul...

Rebuffat, P.; Malendowicz, L. K.; Andreis, P. G.; Meneghelli, V.; Kasprzak, A.; Nussdorfer, G. G.

1992-01-01

197

Propofol infusion syndrome in a super morbidly obese patient (BMI = 75)  

OpenAIRE

Propofol infusion syndrome (PRIS) is a rare but often fatal complication as a result of large doses of propofol infusion (4–5 mg/kg/hr) for a prolonged period (>48 h). It has been reported in both children and adults. Besides large doses of propofol infusion, the risk factors include young age, acute neurological injury, low carbohydrate and high fat intake, exogenous administration of corticosteroid and catecholamine, critical illness, and inborn errors of mitochondrial fatty acid oxidatio...

Ramaiah, Ramesh; Lollo, Loreto; Brannan, Douglas; Bhananker, Sanjay M.

2011-01-01

198

Safe and tolerable one-hour pamidronate infusion for multiple myeloma patients  

OpenAIRE

Dimitrios Chantzichristos, Andréasson Björn, Johansson PeterDepartment of Internal Medicine, Uddevalla Hospital, Uddevalla, SwedenBackground: Once a month, patients with multiple myeloma received an infusion of bisphosphonates, principally to reduce osteoclastic bone resorption. Recommended infusion time for pamidronate is 2 hours in the US and 4 hours in Europe because of its potential nephrotoxicity. From 2003, a 90 mg infusion of pamidronate was provided over 1 hour to ...

Dimitrios Chantzichristos; Andréasson Björn; Johansson Peter

2008-01-01

199

A Multicenter Retrospective Experience of Infliximab in Crohn's Disease Patients: Infusion Reaction Rates and Treatment Persistency  

OpenAIRE

Background: Infusion reactions have been associated with infliximab therapy, but no study has assessed how physicians treat and manage this common adverse event. Goals: To determine how gastroenterologists manage infusion reactions, identify prophylactic pretreatment protocols, and determine infliximab treatment persistence in the presence of infusion reactions. Method: This retrospective multicenter chart review analyzed data from adults younger than 90 years at the time of their first infli...

Keshavarzian, Ali; Mayer, Lloyd; Salzberg, Bruce; Garone, Michael; Finkelstein, Warren; Cappa, Joseph; Brand, Myron; Hain, Jon; Zelinger, David; Hegedus, Ronald; Diamond, Robert H.; Campbell, Ulka; Lane, Christi; Stang, Paul; Watson, John

2007-01-01

200

Hepatic artery infusion (HAI) for hepatic metastases in combination with hepatic resection and hepatic radiation  

International Nuclear Information System (INIS)

Renewed interest in hepatic artery infusion has been stimulated by the development of a totally implantable pump which eliminates many of the problems encountered by the external pumps and catheters. As the potential benefit of hepatic artery infusion would be greater if either all gross disease were removed by prior resection, or alternatively, if non-resectable disease were irradiated in conjunction with hepatic artery infusion, the authors initiated a phase I-II trial to evaluate combined modality therapy

201

Is continuous infusion of beta-lactam antibiotics worthwhile?--efficacy and pharmacokinetic considerations  

OpenAIRE

The most important pharmacodynamic parameter for beta-lactam antibiotics has been shown to be the time above the MIC, which is used as an argument to administer beta-lactam antibiotics by continuous infusion. Studies in vitro and in laboratory animals comparing efficacy of continuous and intermittent infusion of beta-lactam antibiotics generally show continuous infusion to be more efficacious. While comparative trials in humans ...

Mouton, J. W.; Vinks, A. A.

1996-01-01

202

Protocol-directed insulin infusion sliding scales improve perioperative hyperglycaemia in critical care  

OpenAIRE

Abstract Perioperative hyperglycaemia is associated with poor outcomes in patients undergoing cardiac surgery. Frequent postoperative hyperglycaemia in cardiac surgery patients has led to the initiation of an insulin infusion sliding scale for quality improvement. A systematic review was conducted to determine whether a protocol-directed insulin infusion sliding scale is as safe and effective as a conventional practitioner-directed insulin infusion sliding scale, within targe...

Hui Man; Kumar Arun; Adams Gary G

2012-01-01

203

Augmentation of Chemotherapeutic Infusion Effect by TSU-68, an Oral Targeted Antiangiogenic Agent, in a Rabbit VX2 Liver Tumor Model  

International Nuclear Information System (INIS)

Purpose: This study was designed to investigate the in vivo effects of combination therapy with TSU-68 and chemotherapeutic infusion in a rabbit VX2 liver tumor model. Methods: This study was approved by the animal care committee at our institute. Three weeks before chemotherapeutic infusion, VX2 carcinoma was implanted into the livers of 32 rabbits. One week after chemotherapeutic infusion, vehicle was administered orally for 3 weeks in the control group (n = 16), and TSU-68 was administered orally at a daily dose of 200 mg/kg for 3 weeks in the treated group (n = 16). Computed tomography (CT) was performed before and 1, 2, 3, and 4 weeks after chemotherapeutic infusion. Tumor response was assessed according to the Response Evaluation Criteria in Solid Tumors (RECIST) on CT scan. The maximum thickness of viable tumor was measured on microscopic sections. Results: According to the RECIST, stable disease was observed in 9 (56%) rabbits and progressive disease in 7 (44%) in the control group, whereas partial response was observed in 1 (6%) rabbit and stable disease in 15 (94%) in the treated group. On pathologic examination, a viable lesion was present in 12 (75%) rabbits in the control group and in 6 (38%) rabbits in the treated group (P = 0.073). The mean maximum thickness of viable tumor in the treated group was significantly smaller than that in the control group (0.74 mm vs. 3.39 mm; P = 0.02). Conclusions: Oral administration of TSU-68 augmented the effect of chemion of TSU-68 augmented the effect of chemotherapeutic infusion in a rabbit VX2 liver tumor model.

204

Rapid-Infusion Rituximab in Lymphoma Treatment: 2-Year Experience in a Single Institution  

Science.gov (United States)

Purpose: Rituximab is a chimeric anti-CD20 monoclonal antibody. We aimed to explore the safety and tolerability of rapid infusion rituximab, (over 90 minutes) in patients with non-Hodgkin's lymphoma at Hacettepe University Department of Medical Oncology. Patients and Methods: Adult patients diagnosed with non-Hodgkin's lymphoma who were to receive rituximab were included in the study. The schedule of administration for cycle 1 was unaltered and delivered according to the product monograph. All subsequent cycles were administered over a total infusion time of 90 minutes (20% of the dose in the first 30 minutes, then the remaining 80% over 60 minutes, total dose delivered in 500 mL). All patients were observed for infusion-related reactions during the rituximab infusion, and vital signs were recorded every 15 minutes. Results: From July 2006 to December 2008, 75 patients with non-Hodgkin's lymphoma were treated with rituximab-based chemotherapy. A total of 372 infusions were administered. The majority of patients were treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone, or rituximab only. The 90-minute rituximab infusion schedule was well tolerated, with no grade 3 or 4 infusion-related adverse events observed. Conclusion: A rapid infusion rituximab over 90 minutes is well tolerated and safe when administered as the second and subsequent infusions in the course of therapy. PMID:22942806

Atay, Sevcan; Barista, Ibrahim; Gundogdu, Fatma; Akgedik, Kiymet; Arpaci, Afey

2012-01-01

205

Radiographic and Histologic Study After Infusion of Contrast Media into Rabbit Submandibular Gland  

International Nuclear Information System (INIS)

50 submandibular glands of rabbits were examined historadiologically after infusion with normal and over volumes of physiologic saline and 5 radiographic contrast media. The results were as follows: 1. All water soluble contrast media showed similar radiographic contrasts and absorbed about 5 minutes after infusion except Telebrix 30 which took 30 minutes in both normal and overfilled glands. 2. Lipid soluble medium, Lipiodol UF had excellent radiographic contrast and could be seen on the radiograms even after 24 hours after infusion. 3. Salivary glands infused with physiologic saline didn't show any histologic changes except slight duct dilation right after infusion. 4. Telebrix 30 caused mild to moderate duct dilation and inflammation at immediate and 24 hours after infusion which was more severe in overfilled glands. At 7 days after infusion, there were mild to moderate fibrosis of the gland and areas of necrosis was seen in overfilled glands. 5. Hypaque 60% showed similar histologic reactions to Telebrix 30 except more severe tissue destruction at 7 days after infusion. 6. Urografin 60% showed mildest histologic changes among the media used in the study. 7. Biliscopin had mild duct dilation which returned to normal after 7 days but there were moderate inflammation and tissue necrosis at that time. 8. Lipiodol UF showed severe duct dilation with numerous vacuoles and there were tissue fibrosis at 7 days after infusion but no tissue necrosis was seen.o tissue necrosis was seen.

206

Plasma Calcium, Inorganic Phosphate and Magnesium During Hypocalcaemia Induced by a Standardized EDTA Infusion in Cows  

Directory of Open Access Journals (Sweden)

Full Text Available The intravenous Na2EDTA infusion technique allows effective specific chelation of circulating Ca2+ leading to a progressive hypocalcaemia. Methods previously used were not described in detail and results obtained by monitoring total and free ionic calcium were not comparable due to differences in sampling and analysis. This paper describes a standardized EDTA infusion technique that allowed comparison of the response of calcium, phosphorus and magnesium between 2 groups of experimental cows. The concentration of the Na2EDTA solution was 0.134 mol/l and the flow rate was standardized at 1.2 ml/kg per hour. Involuntary recumbency occurred when ionised calcium dropped to 0.39 – 0.52 mmol/l due to chelation. An initial fast drop of ionized calcium was observed during the first 20 min of infusion followed by a fluctuation leading to a further drop until recumbency. Pre-infusion [Ca2+] between tests does not correlate with the amount of EDTA required to induce involuntary recumbence. Total calcium concentration measured by atomic absorption remained almost constant during the first 100 min of infusion but declined gradually when the infusion was prolonged. The concentration of inorganic phosphate declined gradually in a fluctuating manner until recumbency. Magnesium concentration remained constant during infusion. Such electrolyte responses during infusion were comparable to those in spontaneous milk fever. The standardized infusion technique might be useful in future experimental studies.

Enemark JMD

2001-06-01

207

Clinical evaluation of preoperative arterial infusion chemotherapy and surgical operation for colorectal carcinoma  

International Nuclear Information System (INIS)

Objective: To investigate the clinical values of preoperative arterial infusion chemotherapy and surgical operation for colorectal carcinoma. Methods: 66 patients with colorectal carcinoma were subjected to percutaneous femoral artery catheterization by Seldinger's technique with infusion of anti-cancer drugs. The resection was performed 5-30 days after the arterial infusion (mean 12 days). In 50 surgical specimens of the 66 cases, histological findings were evaluated including the density and distribution of the apoptosis cells under the observation by DNA nick end labelling technique. Of which 22 specimens before arterial infusion chemotherapy (got from biopsy of preoperation) and 25 normal mucosa (got from normal surgical specimens) were used as controls. Results: The total histological response rate was 100% with grade I in 20 cases, grade II in 21 cases, grade III in 9 cases. The densities of the apoptosis cells were 31.47 ± 5.58 before arterial infusion chemotherapy, 76.69 ± 17.12 after arterial infusion chemotherapy and 8.01 ± 3.39 in normal mucosa. The density of the apoptosis cells after arterial infusion chemotherapy was significantly higher than that before arterial infusion chemotherapy (P2=4.696, P>0.30). There were no significant differences in the apoptosis of adenocarcinoma during different pathological stages (F=0.001376, P>0.05). Conclusions: Peroperative transcatheter arterial infusion chemotherapy resulting in apoptosis of adenocarcinoma, can raise the radical operation rate, and prolong survival rate for colorectal carcinoma patients

208

Vacuum infusion manufacturing and experimental characterization of Kevlar/epoxy composites  

Energy Technology Data Exchange (ETDEWEB)

Epoxy/Kevlar composites have been manufactured by conventional Vacuum Infusion process and the Pulse Infusion technique. Pulse Infusion allows to control the pressure of the vacuum bag on the dry fiber reinforcement by using a proper designed pressure distributor that induces a pulsed transverse action and promotes the through thickness resin flow. The realized composite panel have been mechanically characterized by performing tensile and short beam shear tests according with the ASTM D3039 and ASTM D2344/D 2344M standard respectively in order to investigate the effect of Pulse Infusion on the tensile strength and ILSS.

Ricciardi, M. R.; Giordano, M.; Antonucci, V. [National Research Council, Institute for Composite and Biomedical Materials, P.le Enrico Fermi, 1, 80055 Portici (Italy); Langella, A.; Nele, L. [University of Naples Federico II, Chemical, Materials and Production Engineering Department, P.le Tecchio 80, 80125 Naples (Italy)

2014-05-15

209

Vacuum infusion manufacturing and experimental characterization of Kevlar/epoxy composites  

Science.gov (United States)

Epoxy/Kevlar composites have been manufactured by conventional Vacuum Infusion process and the Pulse Infusion technique. Pulse Infusion allows to control the pressure of the vacuum bag on the dry fiber reinforcement by using a proper designed pressure distributor that induces a pulsed transverse action and promotes the through thickness resin flow. The realized composite panel have been mechanically characterized by performing tensile and short beam shear tests according with the ASTM D3039 and ASTM D2344/D 2344M standard respectively in order to investigate the effect of Pulse Infusion on the tensile strength and ILSS.

Ricciardi, M. R.; Giordano, M.; Langella, A.; Nele, L.; Antonucci, V.

2014-05-01

210

Vacuum infusion manufacturing and experimental characterization of Kevlar/epoxy composites  

International Nuclear Information System (INIS)

Epoxy/Kevlar composites have been manufactured by conventional Vacuum Infusion process and the Pulse Infusion technique. Pulse Infusion allows to control the pressure of the vacuum bag on the dry fiber reinforcement by using a proper designed pressure distributor that induces a pulsed transverse action and promotes the through thickness resin flow. The realized composite panel have been mechanically characterized by performing tensile and short beam shear tests according with the ASTM D3039 and ASTM D2344/D 2344M standard respectively in order to investigate the effect of Pulse Infusion on the tensile strength and ILSS

211

A comparison of continuous infusion of vecuronium and atracurium in midline and paramedian laparotomies.  

OpenAIRE

This was a study to compare continuous intravenous infusion of atracurium with continuous intravenous infusion of vecuronium for intraoperative muscle relaxation in 62 ASA I / II patients. Scheduled for laparotomies and pelvic surgeries under general anaesthesia. They were randomly allocated in two groups to receive either vecuronium infusion of 50 microg/kg/hour following a bolus dose of 0.1 microg/kg, or atracurium infusion of 400 microg/kg/hour following a bolus dose of 0.5 microg/kg. The ...

Chaudhari L; Shetty A; Buddhi M; Krishnan G

1999-01-01

212

HEMOGLOBIN INFUSION DOES NOT ALTER MURINE PULMONARY VASCULAR TONE  

Science.gov (United States)

Plasma hemoglobin (Hb) scavenges endothelium-derived nitric oxide (NO), producing systemic and pulmonary vasoconstriction in many species. We hypothesized that i.v. administration of murine cell-free Hb would produce pulmonary vasoconstriction and enhance hypoxic pulmonary vasoconstriction (HPV) in mice. To assess the impact of plasma Hb on basal pulmonary vascular tone in anesthetized mice we measured left lung pulmonary vascular resistance (LPVRI) before and after infusion of Hb at thoracotomy. To confirm the findings obtained at thoracotomy, measurements of right ventricular systolic pressure (RVSP) and systemic arterial pressure (SAP) were obtained in closed-chest wild-type mice. To elucidate whether pretreatment with Hb augments HPV we assessed the increase in LPVRI before and during regional lung hypoxia produced by left mainstem bronchial occlusion (LMBO) in wild-type mice pretreated with Hb. Infusion of Hb increased SAP but did not change pulmonary arterial pressure (PAP), left lung pulmonary arterial flow (QLPA) or LPVRI in either wild-type or diabetic mice with endothelial dysfunction. Scavenging of NO by plasma Hb did not alter HPV in wild-type mice. Inhibition of NO synthase with L-NAME did not change the basal LPVRI, but augmented HPV during LMBO. Our data suggest that scavenging of NO by plasma Hb does not alter pulmonary vascular tone in mice. Therefore, generation of NO in the pulmonary circulation is unlikely to be responsible for the low basal pulmonary vascular tone of mice. PMID:23313572

Beloiartsev, Arkadi; Baron, David M.; Yu, Binglan; Bloch, Kenneth D.; Zapol, Warren M.

2013-01-01

213

L-ornithine-L-aspartate infusion efficacy in hepatic encephalopathy  

International Nuclear Information System (INIS)

To determine the efficacy of L-ornithine-L-aspartate in treatment of hepatic encephalopathy. Cirrhotic patients with hyperammonemia and overt hepatic encephalopathy were enrolled. Eighty patients were randomized to two treatment groups, L-ornithine-L-aspartate (20g/d) or placebo, both dissolved in 250mL of 5% dextrose water and infused intravenously for four hours a day for five consecutive days with 0.5 g/kg dietary protein intake at the end of daily treatment period. Outcome variables were postprandial blood ammonia and mental state grade. Adverse reactions and mortality were also determined. Both treatment groups were comparable regarding age, gender, etiology of cirrhosis, Child-Pugh class, mental state grade and blood ammonia at baseline. Although, improvement occurred in both groups, there was a greater improvement in L-ornithine-L-aspartate group with regard to both variables. Four patients in the placebo group and 2 in L-ornithine-L-aspartate group died. L-ornithine-L-aspartate infusions were found to be effective in cirrhotic patients with hepatic encephalopathy. (author)

214

Technology Transition a Model for Infusion and Commercialization  

Science.gov (United States)

The National Aeronautics and Space Administration has as part of its charter the mission of transferring technologies developed for the space program into the private sector for the purpose of affording back to the American people the economical and improved quality of life benefits associated with the technologies developed. In recent years considerable effort has been made to use this program for not only transitioning technologies out of the NASA Mission Directorate Programs, but also to transfer technologies into the Mission Directorate Programs and leverage the impact of government and private sector innovation. The objective of this paper is to outline an approach and the creation of a model that brings together industry, government, and commercialization strategies. When these elements are integrated, the probability of successful technology development, technology infusion into the Mission Programs, and commercialization into the private sector is increased. This model primarily addresses technology readiness levels between TRL 3 and TRL 6. This is typically a gap area known as the valley of death. This gap area is too low for commercial entities to invest heavily and not developed enough for major programs to actively pursue. This model has shown promise for increasing the probably of TRL advancement to an acceptable level for NASA programs and/or commercial entities to afford large investments toward either commercialization or infusion.

McMillan, Vernotto C.

2006-01-01

215

Anaphylactoid reactions after infusion of radiographic contrast media  

International Nuclear Information System (INIS)

Pathophysiology and Prophylaxis: Anaphylactoid reactions after infusion of radiographic contrast media (RCM) do not occur infrequently (5-20%). The pathophysiology of these reactions is not totally clear. In the majority of the reactions, immunological mechanisms do not seem to play a role; rather pseudo-allergic mechanisms are involved, namely the direct liberation of vasoactive mediator substances (e.g. histamine) or activation of the complement, coagulation or kallikrein-kinin system. For the prophylaxis of RCM-induced reactions, different drugs have been recommended such as antihistamines, gluco-corticosteroids, adrenergic agents, epsilonaminocaproic acid, psychopharmaca or hypnotic suggestion. In a controlled randomized study with 800 patients undergoing intravenous urography, the efficacy of 3 different pretreatment schedules (H1-antagonists, combined H1 + H2-antagonists, prednisolone) was compared to a placebo control. It was found that the application of combined H1- and H2-antagonists 5 minutes prior to RCM infusion significantly reduced the frequency of objective anaphylactoid reactions. Neither H1-antagonists alone nor prednisolone (250 mg) showed an effect in this study. (orig.)

216

Continuous venovenous renal replacement therapy using a conventional infusion pump.  

Science.gov (United States)

To evaluate continuous venovenous hemofiltration and hemodiafiltration with a conventional infusion pump in a pediatric sized animal model. Fourteen Maryland pigs weighing 8 to 13 kg were used. A conventional infusion pump (IVAC 571), with a flow of 900 ml/h and a pediatric hemofilter of 0.22 m2 were used. Ringer's solution was used for both the dialysate and the replacement fluid. Each experiment included 1 hour of hemofiltration and 1 hour of hemodiafiltration. Heart rate, arterial blood pressure, pH, Na, K, Cl, and hematocrit were measured every 30 minutes. Mean ultrafiltrate flow was 249.7 +/- 100.3 ml/hr, 240.5 +/- 109.5 ml/hr with hemofiltration and 271 +/- 101.1 ml/hr with hemodiafiltration, the differences not being significant. No significant changes were seen in heart rate, blood pressure, hematocrit, electrolytes, or pH. Pressure in the circuit rose from 107.7 +/- 70.3 mm Hg at the beginning of the experiment to 234.2 +/- 118.1 mm Hg after 2 hours (p extrarenal replacement therapy in neonates and infants. PMID:11482478

Sánchez, C; López-Herce, J; García, E; Moreno de Guerra, M; Moral, R; Carrillo, A

2001-01-01

217

Tea and herbal infusions: Their antioxidant activity and phenolic profile  

International Nuclear Information System (INIS)

Tea and herbal infusions have been studied for their polyphenolic content, antioxidant activity and phenolic profile. The total phenolics recovered by ethyl acetate from the water extract, were determined by the Folin-Ciocalteu procedure and ranged from 88.1 ± 0.42 (Greek mountain tea) to 1216 ± 32.0 mg (Chinese green tea) GAE (Gallic acid equivalents)/cup. The antioxidant activity was evaluated by two methods, DPPH and chemiluminescence assays, using Trolox and quercetin as standards. The EC50 of herbal extracts ranged from 0.151 ± 0.002 mg extract/mg DPPH (0.38 quercetin equivalents and 0.57 Trolox equivalents), for Chinese green tea, to 0.77 ± 0.012 mg extract/mg DPPH (0.08 quercetin equivalents and 0.13 Trolox equivalents), for Greek mountain tea. Chemiluminescence assay results showed that the IC50 ranged from 0.17 ± 3.4 x 103 lg extract/ml of the final solution in the measuring cell (1.89 quercetin and 5.89 Trolox equivalents) for Chinese green tea, to 1.10 ± 1.86 x 102 g extract/ml of the final solution in the measuring cell (0.29 quercetin and 0.90 Trolox equivalents) for Greek mountain tea. The phenolic profile in the herbal infusions was investigated by LC-DAD-MS in the positive electrospray ionization (ESI) mode. About 60 different flavo- noids, phenolic acids and their derivatives have been identified. (author)

218

Morphine infusions into the rostrolateral periaqueductal gray affect maternal behaviors  

Directory of Open Access Journals (Sweden)

Full Text Available It is well established that morphine inhibits maternal behaviors. Previous studies by our group have shown activation of the rostrolateral periaqueductal gray (rlPAG upon inhibition-intended subcutaneous injections of morphine. In this context, we demonstrated that a single naloxone infusion into the rlPAG, following this opioid-induced inhibition, reactivated maternal behaviors. Since these data were obtained by using peripheral morphine injections, the present study was designed to test whether morphine injected directly into the rlPAG would affect maternal behaviors. Our hypothesis that morphine acting through the rlPAG would disrupt maternal behaviors was confirmed with a local infusion of morphine. The mothers showed shorter latency for locomotor behavior to explore the home cage (P = 0.049. Inhibition was especially evident regarding retrieving (P = 0.002, nest building (P = 0.05 and full maternal behavior (P = 0.023. These results support the view that opioidergic transmission plays a behaviorally meaningful inhibitory role in the rostrolateral PAG.

L.M. Moura

2010-09-01

219

Morphine infusions into the rostrolateral periaqueductal gray affect maternal behaviors  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english It is well established that morphine inhibits maternal behaviors. Previous studies by our group have shown activation of the rostrolateral periaqueductal gray (rlPAG) upon inhibition-intended subcutaneous injections of morphine. In this context, we demonstrated that a single naloxone infusion into t [...] he rlPAG, following this opioid-induced inhibition, reactivated maternal behaviors. Since these data were obtained by using peripheral morphine injections, the present study was designed to test whether morphine injected directly into the rlPAG would affect maternal behaviors. Our hypothesis that morphine acting through the rlPAG would disrupt maternal behaviors was confirmed with a local infusion of morphine. The mothers showed shorter latency for locomotor behavior to explore the home cage (P = 0.049). Inhibition was especially evident regarding retrieving (P = 0.002), nest building (P = 0.05) and full maternal behavior (P = 0.023). These results support the view that opioidergic transmission plays a behaviorally meaningful inhibitory role in the rostrolateral PAG.

L.M., Moura; N.S., Canteras; M.H., Sukikara; L.F., Felicio.

2010-09-01

220

The Efficacy of Postoperative Wound Infusion with Bupivacaine for Pain Control after Cesarean Delivery: Randomized Double Blind Clinical Trial  

Directory of Open Access Journals (Sweden)

Full Text Available Objective: This study investigated the efficacy of bupivacaine wound infusion for pain control and opioid sparing effect after cesarean delivery."nMaterials and methods: We conducted a randomized double blind, placebo controlled clinical trial on 60 parturients undergoing cesarean section at a university hospital in Tehran. Patients were randomized to receive a pump infusion system that was filled with either 0.25% bupivacaine or equal volume of distilled water. A catheter was placed above the fascia and connected to electronic pump for 24 hours. Postoperative analog pain scores and morphine consumption were assessed at 6, 12 and 24 hours. Also time interval to first ambulation, length of hospitalization, complications and patient satisfaction were recorded. Data were analyzed using the SPSS software and P < 0.05 was considered statistically significant. Mann-Whitney u-test, student t-test and chi-square were used. "nResults: There were no differences in patient demographics and length of hospitalization and patient-generated resting pain scores between the two groups. Pain scores after coughing and leg raise during the first 6 postoperative hours were significantly less in the Bupivacaine group (P<0.001. The total dose of morphine consumption during the 24 hours study period was 2.5 ± 2.5 mg vs. 7.3 ± 2.7 mg for the bupivacaine and control groups, respectively (P<0.001. Compared with the control group, time to first ambulation was shorter in the bupivacaine group (11± 5h vs. 16 ± 4h (P< 0.01. "nConclusion: Bupivacaine wound infusion was a simple and safe technique that provides effective analgesia and reduces morphine requirements after cesarean delivery.

Azin Alavi

2007-06-01

221

Pharmacokinetics and pharmacodynamics of continuous infusion of cefepime in cystic fibrosis patients, and stability of cefepime during simulated continuous infusion administration  

OpenAIRE

Time above minimal inhibitory concentration (MIC) (T>MIC) is the PK/PD parameter that best correlates with bacterial killing for cefepime. Cefepime CI provides an efficient method of achieving T>MIC throughout the dosing interval. The purpose of this study was to determine whether cefepime exhibits sufficient stability and antibacterial activity to be given by 24-hour CI using portable infusion pumps. In addition, assess the PK and PD of CI versus intermittent infusion of cefepi...

Sprauten, Pa?l Falck

2002-01-01

222

Septal co-infusions of glucose with the benzodiazepine agonist chlordiazepoxide impair memory, but co-infusions of glucose with the opiate morphine do not  

OpenAIRE

We have found repeatedly that medial septal (MS) infusions of glucose impair memory when co-infused with the ?-amino butyric acid (GABA) agonist muscimol. The present experiment sought to determine whether the memory-impairing effects of this concentration of glucose would generalize to another GABAA receptor agonist and to an agonist from another neurotransmitter system that is known to impair memory. Specifically, we determined whether the dose of glucose that produces memory deficits when...

Krebs-kraft, Desiree L.; Parent, Marise B.

2009-01-01

223

Dimensionnement d'un fuselage composite réalisé par infusion de résine = Numerical modeling of an aircraft composite fuselage manufactured by Liquid Resin Infusion  

OpenAIRE

Le projet FUSCOMP (FUSelage COMPosite) est un programme de Recherche & Développement qui a reçu la labellisation du pôle de compétitivité de l'Aerospace Valley. Il mènera d'ici 2011 au test d'un démonstrateur de fuselage composite réalisé par le procédé d'infusion de résine LRI (Liquid Resin Infusion). Ce procédé utilise une résine liquide infusée dans des tissus secs plutôt que des tissus préimprégnés, pour mettre en oeuvre des pièces en matériaux composites hautes perf...

Perret, Adrien; Mistou, Se?bastien; Denaud, Louis-etienne; Veyrac, Claudia; Molle?, Thierry; Karama, Moussa

2009-01-01

224

Does prolonged ?-lactam infusions improve clinical outcomes compared to intermittent infusions? A meta-analysis and systematic review of randomized, controlled trials  

OpenAIRE

Abstract Background The emergence of multi-drug resistant Gram-negatives (MDRGNs) coupled with an alarming scarcity of new antibiotics has forced the optimization of the therapeutic potential of available antibiotics. To exploit the time above the minimum inhibitory concentration mechanism of ?-lactams, prolonging their infusion may improve outcomes. The primary objective of this meta-analysis was to determine if prolonged ?-lactam infusion resulted in decreased mortality a...

Van Arendonk Kyle J; Suh Yong D; Putcha Nirupama; Tamma Pranita D; Rinke Michael L

2011-01-01

225

Decoction, infusion and hydroalcoholic extract of Origanum vulgare L.: different performances regarding bioactivity and phenolic compounds  

OpenAIRE

Bioactivity of oregano methanolic extracts and essential oils is well known. Nonetheless, reports using aqueous extracts are scarce, mainly decoction or infusion preparations used for therapeutic applications. Herein, the antioxidant and antibacterial activities, and phenolic compounds of the infusion, decoction and hydroalcoholic extract of oregano were evaluated and compared. The antioxidant activity is related with phenolic compounds, mostly flavonoids, since decoction presente...

Martins, Nata?lia; Barros, Lillian; Santos-buelga, Celestino; Henriques, Mariana; Ferreira, Isabel C. F. R.

2014-01-01

226

Administration of 131I-Metaiodobenzylguanidine Using the Peristaltic Infusion Pump Method.  

Science.gov (United States)

Syringe pumps are commonly used to administer therapeutic (131)I-metaiodobenzylguanidine. Here we describe our recent experience with a peristaltic infusion pump system in a pediatric setting. This method can easily accommodate infusions from several vials simultaneously and is adaptable to various types of peristaltic pump. PMID:24799606

Guardia, Miguel de la; McCammon, Steven; Nielson, Karen; Granger, Meaghan

2014-05-01

227

Intraarterial low-dose streptokinase infusion in the treatment of acute renal thromboembolism  

International Nuclear Information System (INIS)

A case of acute renal thromboembolism treated by intraarterial low dose streptokinase infusion is reported. The treatment appears effective, safe and less-invasive then surgery, with quick relief of pain and normalisation of blood pressure and renal function. It is concluded that intraarterial infusion of thrombolytic agents should be attempted first in the treatment of renal arterial thromboembolism. (orig.)

228

Responses of blood glucose, insulin, glucagon, and Fatty acids to intraruminal infusion of propionate in hanwoo.  

Science.gov (United States)

This study was carried out to investigate the effects of intraruminal infusion of propionate on ruminal fermentation characteristics and blood hormones and metabolites in Hanwoo (Korean cattle) steers. Four Hanwoo steers (average body wt. 270 kg, 13 month of age) equipped with rumen cannula were infused into rumens with 0.0 M (Water, C), 0.5 M (37 g/L, T1), 1.0 M (74 g/L, T2) and 1.5 M (111 g/L, T3) of propionate for 1 hour per day and allotted by 4×4 Latin square design. On the 5th day of infusion, samples of rumen and blood were collected at 0, 60, 120, 180, and 300 min after intraruminal infusion of propionate. The concentrations of serum glucose and plasma glucagon were not affected (p>0.05) by intraruminal infusion of propionate. The serum insulin concentration at 60 min after infusion was significantly (pfatty acid (NEFA) at 60 and 180 min after infusion was significantly (p<0.05) lower in the propionate treatments than in C. Hence, intraruminal infusion of propionate stimulates the secretion of insulin, and decreases serum NEFA concentration rather than the change of serum glucose concentration. PMID:25557815

Oh, Y K; Eun, J S; Lee, S C; Chu, G M; Lee, Sung S; Moon, Y H

2015-02-01

229

Brain SPECT by intraarterial infusion of [sup 99m]Tc-HMPAO for assessing the cerebral distribution of carotid artery infusions in patient with brain tumor  

Energy Technology Data Exchange (ETDEWEB)

In order to assess the cerebral distribution of intracarotid chemotherapy, 17 postoperative patients with brain tumor underwent brain SPECT obtrained by intraarterial infusion of 18.5 MBq of [sup 99m]Tc-d,l,-hexamethylpropyleneamine oxime ([sup 99m]Tc-HMPAO). Injection methods were continuous (5.0 ml/min) or pulsatile infusion with supra- or infraophthalmic catheterization. The findings obtained by brain SPECT were frequently different from those of angiography and/or DSA. In supraophthalmic catheterization with continuous infusion, only 2 of 10 studies (20%) had homogeneous distribution and 5 of them (50%) had maldistribution of [sup 99m]Tc-HMPAO which appears in association with laminar flow effect. The remaining 3 studies showed localized distribution (two: tumor localization, one: healthy brain localization). On the other hand, all of 5 studies with pulsatile infusion had homogeneous distribution of [sup 99m]Tc-HMPAO. In infraophthalmic catheterization, all but one of 5 studies had homogeneous distribution with continuous infusion. These results suggest that pulsatile infusion may be effective in eliminating maldistribution of [sup 99m]Tc-HMPAO in supraophthalmic catheterization. In conclusion, we are convinced that [sup 99m]Tc-HMPAO is a useful intraarterial agent for assessing cerebral distribution of intracarotid chemotherpay. (author).

Kosuda, Shigeru; Kusano, Shoichi (National Defense Medical College, Saitama (Japan)); Aoki, Shigeki (and others)

1993-06-01

230

Effects of lipid and propionic acid infusions on feed intake of lactating dairy cows.  

Science.gov (United States)

Propionic acid is more hypophagic for cows with elevated hepatic acetyl coenzyme A (CoA) concentration in the postpartum period. The objective of this experiment was to evaluate the interaction of hepatic acetyl CoA concentration, which is elevated by intravenous lipid infusion, and intraruminal propionic acid infusion on feed intake and feeding behavior responses of lactating cows. Eight multiparous, ruminally cannulated, Holstein dairy cows past peak lactation were used in a replicated 4×4 Latin square experiment with a 2×2 factorial arrangement of treatments. Treatments were propionic acid (PI) infused intraruminally at 0.5mol/h for 18h starting 6h before feeding and behavior monitoring or sham control (CO), and intravenous jugular infusion of lipid (LI, Intralipid 20%; Baxter US, Deerfield, IL) or saline (SI, 0.9% NaCl; Baxter US) infused at 250mL/h for 12h before feeding and behavior monitoring, and then 500mL/h for 12h after feeding. Changes in plasma concentrations of metabolites and hormones and hepatic acetyl CoA from before infusion until the end of infusion were evaluated. We observed a tendency for an interaction between PI and LI for the change in plasma nonesterified fatty acid (NEFA) concentration from the preliminary day to the end of the infusion period. Infusion of propionic acid decreased dry matter intake (DMI) 15% compared with CO, but lipid infusion did not affect DMI over the 12h following feeding. Infusion of propionic acid tended to decrease hepatic acetyl CoA concentration from the preliminary day to the end of the infusion compared with CO, consistent with PI decreasing DMI by stimulating oxidation of acetyl CoA. Contrary to our expectations, LI did not increase concentration of NEFA or ?-hydroxybutyrate in plasma, concentration of acetyl CoA in the liver, or milk fat yield, suggesting that the infused lipid was stored or oxidized by extra-hepatic tissues. As a result, we detected no interaction between PI and LI for DMI. Although the effect of PI on DMI was consistent with our previous results, this lipid infusion model using cows past peak lactation was not useful to simulate the lipolytic state of cows in the postpartum period in this experiment. PMID:24534511

Stocks, S E; Allen, M S

2014-04-01

231

Intravenous ketamine infusions for chronic algodystrophy: a review.  

Science.gov (United States)

Abstract Chronic algodystrophy is difficult to treat, because the disease in this stage is usually resistant to many therapies. It particularly concerns conditions with predominant severe, intractable pain and disability of the involved extremity. In these, the severest cases, searching for effective pain control therapy is extremely important. Intravenous ketamine infusions constitute a promising therapy, which appeared recently. Ketamine possesses properties of blocking central sensitization and development of neuropathic pain through its effect on NMDA receptor, a critical factor in this process. The article presents problem of chronic, refractory algodystrophy, mechanism of ketamine action in pain control, literature review on treatment outcomes and authors' own experience in this field. Ketamine seems to be a useful option for pain control in patients with refractory algodystrophy. PMID:24710331

?yluk, Andrzej; Pastuszka, Joanna

2014-01-01

232

Anaphylactic shock and cardiac arrest caused by thiamine infusion  

DEFF Research Database (Denmark)

Parenteral thiamine has a very high safety profile. The most common adverse effect is local irritation; however, anaphylactic or anaphylactoid reactions may occur, mostly related to intravenous administration. We describe a 44-year-old man, a chronic alcoholic, who was admitted with alcohol intoxication and developed cardiac arrest due to anaphylactic shock following intravenous thiamine infusion. The patient was successfully resuscitated after 15 min and repeated epinephrine administrations. He was discharged in good health after 14 days. This case report emphasises both the importance of recognising the symptoms of anaphylaxis and the fact that facilities for treating anaphylaxis and cardiopulmonary resuscitation should be available when thiamine or for that matter, any drug is given in-hospital.

Juel, Jacob; Pareek, Manan

2013-01-01

233

Pharmacology and therapeutic efficacy of bleomycin administered by continuous infusion  

International Nuclear Information System (INIS)

A study was done at Memorial Hospital in which Bleomycin was given by continuous intravenous infusion to radiation therapy patients with a variety of far advanced unresectable malignant neoplastic diseases. Smaller doses than usual were administered initially, approximately 1/10 the dose that had been previously studied. The dose was gradually escalated when it was shown that there was no acute toxicity from the smaller dose. Bleomycin blood levels were measured by bioassay and pulmonary function was studied by measurement of total lung capacity and carbon monoxide diffusing capacity. In this study, therapeutic activity in cervix cancer appeared to be significantly better than in earlier studies by the same group of investigators. However, in vitro and animal studies in the author's own clinical pharmacologic studies support the logic of continuous intravenous administration in the effort to decrease pulmonary toxicity and to improve therapeutic effect

234

Ist die subkutane Infusion eine praktische Alternative in der Geriatrie?  

Directory of Open Access Journals (Sweden)

Full Text Available In der Geriatrie hat das Thema der Flüssigkeitssubstitution einen besonderen Stellenwert - so verwundert es nicht, daß hauptsächlich Geriater die subkutane Infusion als Methode der Flüssigkeitszufuhr für ihre Patienten wiederentdeckten. Sie gilt heute als einfach, komplikationsarm, sicher und vor allem als für den Patienten schonend. Sie hat viele Vorteile und nur wenige Nachteile. Ihre Domäne ist die Vorbeugung von Dehydratation in Situationen, die dafür ein Risiko darstellen, sowie die Therapie von leichter bis mäßiger Dehydratation. Die bis vor wenigen Jahren, als neue Publikationen zu diesem Thema erschienen, archaisch anmutende Methode wurde jahrzehntelang kaum mehr angewandt und wenn, dann höchstens mit einem schlechten Gewissen und der Verzweiflung, keinen intravenösen Zugang gefunden zu haben. Sie schnitt auch hinsichtlich Sicherheit und Komplikationsrate im Vergleich zu den damals neu entwickelten Technologien und Materialien für den intravenösen Zugang schlechter ab. In einer kurzen Literaturübersicht wird über die Indikationen, Kontraindikationen und die Technik dieser wiederentdeckten Methode der Flüssigkeitssubstitution berichtet.

Frühwald T

2001-01-01

235

Polymeric mandrels: supersmooth finish by an infusion process  

International Nuclear Information System (INIS)

Extremely smooth surfaces (less than 1 mm maximum defect size) have been produced on acrylic polymer rods by an infusion process. The technique involves bathing the rod in a mixture of a solvent and a diluent, a nonsolvent for the polymer. This causes the rod to soften and permits limited flow and leveling of its surface. The solvent is then gradually displaced from the bath by additional diluent. As this occurs, the surface of the rod becomes rigid once more, but now with a defect-free finish. Acetone may be used as the solvent. The smoothest surfaces have been obtained using a mixture of 50% water and 50% polyethylene glycol with a molecular weight of about 4000 as the diluent

236

Attribute based selection of thermoplastic resin for vacuum infusion process : A decision making methodology  

DEFF Research Database (Denmark)

The composite industry looks toward a new material system (resins) based on thermoplastic polymers for the vacuum infusion process, similar to the infusion process using thermosetting polymers. A large number of thermoplastics are available in the market with a variety of properties suitable for different engineering applications, and few of those are available in a not yet polymerised form suitable for resin infusion. The proper selection of a new resin system among these thermoplastic polymers is a concern for manufactures in the current scenario and a special mathematical tool would be beneficial. In this paper, the authors introduce a new decision making tool for resin selection based on significant attributes. This article provides a broad overview of suitable thermoplastic material systems for vacuum infusion process available in today’s market. An illustrative example—resin selection for vacuum infused of a wind turbine blade—is shown to demonstrate the intricacies involved in the proposed methodology for resin selection.

Prabhakaran, R.T. Durai; Lystrup, Aage

2011-01-01

237

Attribute Based Selection of Thermoplastic Resin for Vacuum Infusion Process: A Decision Making Methodology  

DEFF Research Database (Denmark)

The composite industry looks toward a new material system (resins) based on thermoplastic polymers for the vacuum infusion process, similar to the infusion process using thermosetting polymers. A large number of thermoplastics are available in the market with a variety of properties suitable for different engineering applications, and few of those are available in a not yet polymerised form suitable for resin infusion. The proper selection of a new resin system among these thermoplastic polymers is a concern for manufactures in the current scenario and a special mathematical tool would be beneficial. In this paper, the authors introduce a new decision making tool for resin selection based on significant attributes. This article provides a broad overview of suitable thermoplastic material systems for vacuum infusion process available in today’s market. An illustrative example—resin selection for vacuum infused of a wind turbine blade—is shown to demonstrate the intricacies involved in the proposed methodology for resin selection.

Raghavalu Thirumalai, Durai Prabhakaran; Lystrup, Aage

2012-01-01

238

The impact of Ca2+ combination with organic acids on green tea infusions.  

Science.gov (United States)

The effect of Ca(2+) in brewing water on the organic acid content, turbidity, and formation of tea cream and sediment in green tea infusions was studied. When the Ca(2+) concentration of the brewing water was >40 mg L(-1), the green tea infusion became more turbid. The turbidity of the tea infusion was highly negatively correlated with the contents of oxalic acid (R=-0.89, pacid (R=-0.90, pacid (R=-0.82, pacid on its own interacted with Ca(2+) at low concentrations, whereas polyphenols and protein did not. In conclusion, Ca(2+) in brewing water influences the quality of a tea infusion by inducing tea cream and sediment formation from combination of Ca(2+) and organic acids, such as oxalic acid, quinic acid and tartaric acid. Ca(2+) and oxalate are the main metal ion and anion, respectively, involved in tea cream and sediment formation on tea infusion cooling or concentrating. PMID:23561194

Xu, Yong-Quan; Zhong, Xiao-Yu; Yin, Jun-Feng; Yuan, Hai-Bo; Tang, Ping; Du, Qi-Zhen

2013-08-15

239

Long-term BPA infusions. Evaluation in the rat brain tumor and rat spinal cord models  

International Nuclear Information System (INIS)

In the BPA-based dose escalation clinical trial, the observations of tumor recurrence in areas of extremely high calculated tumor doses suggest that the BPA distribution is non-uniform. Longer (6-hour) i.v. infusions of BPA are evaluated in the rat brain tumor and spinal cord models to address the questions of whether long-term infusions are more effective against the tumor and whether long-term infusions are detrimental in the central nervous system. In the rat spinal cord, the 50% effective doses (ED50) for myeloparesis were not significantly different after a single i.p. injection of BPA-fructose or a 6 hour i.v. infusion. In the rat 9L gliosarcoma brain tumor model, BNCT following 2-hr or 6-hr infusions of BPA-F produced similar levels of long term survival. (author)

240

Haemolytic anaemia as a complication to intravenous immunoglobulin infusion  

DEFF Research Database (Denmark)

Intravenous immunoglobulin (IVIg) is an established treatment for various neuromuscular disorders. Recently, we have observed a few cases of haemolytic anaemia following IVIg treatment. The objective of this study was to determine the extent of anaemia and haemolysis as a complication to IVIg. In a prospective study we included 28 post-polio patients treated with 2g per kilo of Privigen® and 22 CIDP patients treated with 1.7±0.4 (mean±SD) g per kilo of Kiovig®. The post-polio patients were all IVIg treatment naitive whereas the CIDP patients were in maintenance therapy. Venous blood samples were performed before and two weeks after infusion of IVIg. Following treatment blood haemoglobin declined from 8.6±0.8 to 8.1±1.3mmol/l, p<0.001. Furthermore, decreasing haptoglobin and increasing reticulocyte count, blood bilirubin, and lactate dehydrogenase were observed, all p<0.05. The decrease of haemoglobin was 0.79±1.2 in the treatment naive versus 0.25±0.3mmol/l in the long-term treated patients, p=0.05. Alterations of reticulocyte count, haptoglobin and lactate dehydrogenase were more pronounced in the treatment naive group, all p<0.05. In 7 patients we observed a substantial decline of haemoglobin of more than 1.5mmol/l (1.8-2.9). Six of those 7 patients had undetectable levels of haptoglobin after IVIg and the mean reticulocyte count, blood bilirubin and lactate dehydrogenase increased 420%, 130% and 108%. All were in the de-novo treated group. Our observations indicate that treatment naive patients are susceptible to develop haemolysis. Haemolytic anaemia is a severe side effect that seems to be more frequent after immunoglobulin infusions than previously recognized.

Markvardsen, Lars HØj; Harbo, Thomas

241

Process Optimization of Bismaleimide (BMI) Resin Infused Carbon Fiber Composite  

Science.gov (United States)

Bismaleimide (BMI) resins are an attractive new addition to world-wide composite applications. This type of thermosetting polyimide provides several unique characteristics such as excellent physical property retention at elevated temperatures and in wet environments, constant electrical properties over a vast array of temperature settings, and nonflammability properties as well. This makes BMI a popular choice in advance composites and electronics applications [I]. Bismaleimide-2 (BMI-2) resin was used to infuse intermediate modulus 7 (IM7) based carbon fiber. Two panel configurations consisting of 4 plies with [+45deg, 90deg]2 and [0deg]4 orientations were fabricated. For tensile testing, a [90deg]4 configuration was tested by rotating the [0deg]4 configirration to lie orthogonal with the load direction of the test fixture. Curing of the BMI-2/IM7 system utilized an optimal infusion process which focused on the integration of the manufacturer-recommended ramp rates,. hold times, and cure temperatures. Completion of the cure cycle for the BMI-2/IM7 composite yielded a product with multiple surface voids determined through visual and metallographic observation. Although the curing cycle was the same for the three panellayups, the surface voids that remained within the material post-cure were different in abundance, shape, and size. For tensile testing, the [0deg]4 layup had a 19.9% and 21.7% greater average tensile strain performance compared to the [90deg]4 and [+45deg, 90deg, 90deg,-45degg] layups, respectively, at failure. For tensile stress performance, the [0deg]4 layup had a 5.8% and 34.0% greater average performance% than the [90deg]4 and [+45deg, 90deg, 90deg,-45deg] layups.

Ehrlich, Joshua W.; Tate, LaNetra C.; Cox, Sarah B.; Taylor, Brian J.; Wright, M. Clara; Caraccio, Anne J.; Sampson, Jeffery W.

2013-01-01

242

Alfentanil used to supplement propofol infusions for oesophagoscopy and bronchoscopy.  

Science.gov (United States)

This randomised double-blinded study compared the cardiovascular stability and rate of recovery when propofol infusions with or without alfentanil were used to provide anaesthesia for rigid oesophagoscopy and (or) bronchoscopy. Forty-six patients were allocated randomly to receive either alfentanil 10 micrograms/kg or saline just before a rapid sequence induction with propofol. Suxamethonium 1 mg/kg was given and infusions of suxamethonium 10 mg/minute and propofol (10 mg/kg/hour for 10 minutes, 8 mg/kg/hour for 10 minutes and then 6 mg/kg/hour thereafter) were started. There were 23 patients in each group with no significant demographic differences between the groups. A significantly mean lower induction dose of propofol was needed in the alfentanil group (1.7 mg/kg compared to 2.2 mg/kg). Cardiovascular measurements were made on the ward pre-operatively, just before induction, just after induction, just after intubation, and at 3-minute intervals thereafter. Arterial pressure was significantly lower during the procedure in the patients who received alfentanil and there was a significant incidence of hypotension. There was no significant difference between the groups in respect of heart rate, with a significant increase in both groups just after intubation compared to the baseline values. Recovery from anaesthesia was assessed using the critical flicker fusion threshold. No differences were found between the groups and patients in both groups had returned to baseline values by 60 minutes. No patient had any recall of intra-operative events, and there were no other adverse effects of any significance. PMID:2694861

Kestin, I G; Chapman, J M; Coates, M B

1989-12-01

243

Intracoronary stem cell infusion in heart transplant candidates  

International Nuclear Information System (INIS)

The stem cell transplantation is emerging as a potential therapeutic modality for patients with heart failure. It has been demonstrated that intracoronary stem cell transplantation had beneficial effects on left ventricular perfusion and contractile functions. We hypothesized that patients with end-stage ischemic cardiomyopathy, who are candidates for heart transplantation, could also benefit from autologous intracoronary stem cell transplantation. We performed a prospective, open-labeled study in 10 patients with end-stage ischemic cardiomyopathy, who were on the waiting list for heart transplantation. Each patient received bone marrow-derived mononuclear cell infusion via balloon catheter in the target vessel, which had been revascularized by percutaneous intervention and was patent before the procedure. Clinical and laboratory evaluations, a treadmill exercise test, echocardiography, and single photon emission tomography (SPECT) were performed to the patients at baseline and 6 months after stem cell infusion. At 6-month follow-up of the eight patients who were able to complete the study, we revealed a significant increase in ejection fraction (from 30.0±6.6% to 36.2±7.3%; p=0.001) in echocardiographic evaluation. SPECT evaluation also displayed a reduction in infarct area (50.4±16.1% to 44.1±12.5%; p=0.003). Both myocardial oxygen consumption (p=0.001) and metabolic equivalents (p=0.001) were significantly increased at 6-month follow-up. These results demonstranth follow-up. These results demonstrate that intracoronary stem cell transplantation ameliorates heart failure symptoms and improves left ventricular function and perfusion. Therefore intracoronary stem cell transplantation may be used as an alternative treatment option for heart transplant candidates. (author)

244

Evaluation of free radical scavenging activity of tea infusion of commercial tea products available in uae  

International Nuclear Information System (INIS)

In the present study, twenty four commercial tea samples were assayed to determine their free radical scavenging activity and polyphenolic contents based on the brewing/infusing period. Tea samples were infused/brewed in 200 mL boiled water at 120 degree C for 1, 2 and 5 min, respectively. The radical scavenging activities of tea infusion/brewing were measured using 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) assay method. The results were ranged from 67.81-90.51% for black tea bags, 90.37-94.51% for green tea bags, 24.66-92.25% for black tea powder, 16.08-93.06% for green tea powder and 32.90- 45.54% for Camomile herbal infusion. The results showed that 1 or 2 min black tea bags infusion exhibited highest radical scavenging activity than 5 min infusion. Antioxidant activities of tea powders were variable with the amount of tea powder. It was observed that antioxidant activity increased with increasing boiling time for smaller amount of sample. In contrary, shorter boiling time was better for larger amount of sample. The polyphenol contents of tea infusion were determined and the results were expressed as milligram quercetin equivalent/200 mL of tea infusion. The polyphenol content was increased with increased brewing period. In contrary, brewing for longer time rendered extract less antiradical activity. This study suggests that infusing tea bag for 1 or 2 min is sufficient for getting infusion with maximum radical scavenging activity and in case of tea powder, shorter boiling time is better for larger amount of powder or small amount of powder should be boiled for minimum 5 min for rendering extract with maximum radical scavenging activity. (author)

245

Systemic and regional hemodynamic effects of enalaprilat infusion in experimental normotensive sepsis  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english Angiotensin-converting enzyme inhibitors have been shown to improve splanchnic perfusion in distinct shock states. We hypothesized that enalaprilat potentiates the benefits of early fluid resuscitation in severe experimental sepsis, particularly in the splanchnic region. Anesthetized and mechanicall [...] y ventilated mongrel dogs received an intravenous infusion of live Escherichia coli over a period of 30 min. Thereafter, two interventions were performed: fluid infusion (normal saline, 32 mL/kg over 30 min) and enalaprilat infusion (0.02 mg kg-1 min-1 for 60 min) in randomized groups. The following groups were studied: controls (fluid infusion, N = 4), E1 (enalaprilat infusion followed by fluid infusion, N = 5) and E2 (fluid infusion followed by enalaprilat infusion, N = 5). All animals were observed for a 120 min after bacterial infusion. Mean arterial pressure, cardiac output (CO), portal vein blood flow (PVBF), systemic and regional oxygen-derived variables, and lactate levels were measured. Rapid and progressive reductions in CO and PVBF were induced by the infusion of live bacteria, while minor changes were observed in mean arterial pressure. Systemic and regional territories showed a significant increase in oxygen extraction and lactate levels. Widening venous-arterial and portal-arterial pCO2 gradients were also detected. Fluid replacement promoted transient benefits in CO and PVBF. Enalaprilat after fluid resuscitation did not affect systemic or regional hemodynamic variables. We conclude that in this model of normotensive sepsis inhibition of angiotensin-converting enzyme did not interfere with the course of systemic or regional hemodynamic and oxygen-derived variables.

L., Rahal; A.G., Garrido; R.J., Cruz Jr.; M., Rocha e Silva; L.F., Poli-de-Figueiredo.

1205-12-01

246

Anti-Peroxyl Radical Quality and Antibacterial Properties of Rooibos Infusions and Their Pure Glycosylated Polyphenolic Constituents  

OpenAIRE

The anti-peroxyl radical quality of two aqueous rooibos infusions and solutions of their most abundant glycosylated polyphenols was evaluated using pyrogallol red and fluorescein-based oxygen radical absorbance ratios. It was observed that the artificial infusions, prepared using only the most abundant polyphenols present in rooibos and at concentrations similar to those found in the natural infusions, showed greater antioxidant quality than the latter infusions, reaching values close to thos...

Udekwu, Klas I.; Elizabeth Joubert; Eduardo Lissi; Baback Salehani; Akop Yepremyan; Minehan, Thomas G.; Camilo López-Alarcón; Nadja Karamehmedovic; Daisy Hjelmqvist; Simpson, Madeline J.; Alarcon, Emilio I.

2013-01-01

247

Bile duct complications of hepatic arterial infusion chemotherapy evaluated by helical CT  

Energy Technology Data Exchange (ETDEWEB)

AIM: To describe the imaging findings of bile duct complications of hepatic arterial infusion chemotherapy (HAIC) using helical CT, to set diagnostic criteria, to develop a CT grading system, and to correlate these with clinical findings and laboratory data. METHODS: Follow-up helical CT of the abdomen was performed every 3 months for 60 patients receiving HAIC. Three radiologists reviewed all CT studies before and after treatment, using either the picture archiving and communication system or hard copies. The findings of bile duct abnormalities were correlated with findings from other imaging techniques, clinical symptoms and laboratory data. RESULTS: Bile duct abnormalities developed in 34 (57%) of cases either during HAIC or 1 to 12 months after treatment. In 14 (41%) of these 34 patients, enhancement of the hepatic parenchyma along the dilated bile duct or in the segmental or lobar distribution was observed. In 43 cases (72%), normal or abnormal alkaline phosphatase levels were consistent with normal or abnormal CT findings, respectively. Increasing alkaline phosphatase and bilirubin levels were related to CT grade. CONCLUSION: Imaging findings of bile duct complications of HAIC are similar to those of primary sclerosing cholangitis, and correlate well with abnormal clinical and laboratory data. In the presence of such clinical abnormalities, thin-section helical CT with careful review of the imaging studies helps to determine the correct diagnosis, monitor the changes and guide appropriate treatment.

Phongkitkarun, S. [Department of Diagnostic Radiology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States)]. E-mail: rasih@mahidol.ac.th; Kobayashi, S. [Department of Diagnostic Radiology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Varavithya, V. [Department of Diagnostic Radiology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Huang, X. [Department of Biostatistics, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Curley, S.A. [Department of Surgical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Charnsangavej, C. [Department of Diagnostic Radiology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States)

2005-06-01

248

Extended-Infusion versus standard-infusion piperacillin-tazobactam for sepsis syndromes at a tertiary medical center.  

Science.gov (United States)

Piperacillin-tazobactam (PTZ) is frequently used as empirical and targeted therapy for Gram-negative sepsis. Time-dependent killing properties of PTZ support the use of extended-infusion (EI) dosing; however, studies have shown inconsistent benefits of EI PTZ treatment on clinical outcomes. We performed a retrospective cohort study of adult patients who received EI PTZ treatment and historical controls who received standard-infusion (SI) PTZ treatment for presumed sepsis syndromes. Data on mortality rates, clinical outcomes, length of stay (LOS), and disease severity were obtained. A total of 843 patients (662 with EI treatment and 181 with SI treatment) were available for analysis. Baseline characteristics of the two groups were similar, except for fewer female patients receiving EI treatment. No significant differences between the EI and SI groups in inpatient mortality rates (10.9% versus 13.8%; P = 0.282), overall LOS (10 versus 12 days; P = 0.171), intensive care unit (ICU) LOS (7 versus 6 days; P = 0.061), or clinical failure rates (18.4% versus 19.9%; P = 0.756) were observed. However, the duration of PTZ therapy was shorter in the EI group (5 versus 6 days; P treatment. We did not observe significant differences in inpatient mortality rates, overall LOS, ICU LOS, or clinical failure rates between patients receiving EI PTZ treatment and patients receiving SI PTZ treatment. Patients receiving EI PTZ treatment had a shorter duration of PTZ therapy than did patients receiving SI treatment, and EI dosing may provide cost savings to hospitals. PMID:24867975

Cutro, Scott R; Holzman, Robert; Dubrovskaya, Yanina; Chen, Xian Jie Cindy; Ahuja, Tania; Scipione, Marco R; Chen, Donald; Papadopoulos, John; Phillips, Michael S; Mehta, Sapna A

2014-08-01

249

Is routine replacement of i.v. administration sets required after each change of intermittently administrated antibiotic infusions?  

Directory of Open Access Journals (Sweden)

Full Text Available [english] Aim: Manufacturers’ instructions recommend changing the infusion line together with the infusion bottle after each administration. We investigated if the complete infusion line may be microbiologically contaminated after short-time antibiotic and rinse-solution application.Method: Immediately after the change of an infusion administration set after 72 hours the remaining antibiotic solution was inactivated with yolk and cultured on blood agar for 48 hours at 36°C to detect possible contaminants.Results: Among 87 investigated samples no microbial growth was detected. One sample which hadn’t any contact to antibiotics yielded forming unit (cfu of coagulase-negative staphylococci.These results suggest that in case of consecutive antibiotic-short- and rinse-infusions the infusion line may be in place up to 72 hours without contamination. This, however, may be only the case for infusion sets, which are in contact with antibiotics. If no antibiotic is administered, the infusion bottle and the infusion line must be renewed together for every change. To clarify this question into more detail, a larger consecutive study is required. Conclusion: I.v. administration sets without any contact to antibiotics must be changed together with their infusion bottle after administration. In case of consecutive antibiotic-short- and rinse-infusions our pilot study suggests using the i.v. administration sets for up to 72 hours without renewing it at every infusion-set exchange.

von Au, Felix

2013-04-01

250

Increased neutrophil mobilization and decreased chemotaxis during cortisol and epinephrine infusions.  

Science.gov (United States)

Although hormones are putative mediators of neutrophil changes after injury, the effects of trauma-induced levels of plasma cortisol and epinephrine on circulating neutrophils have not been reported in humans. The dynamics of PMN mobilization and chemotaxis were evaluated during 19 infusions of epinephrine or cortisol or a combined infusion of both hormones in ten normal volunteers. Basal levels of epinephrine and cortisol increased during infusions to levels consistent with those reported following severe injury. Circulating neutrophil counts increased in parallel with plasma cortisol levels. Epinephrine mobilized the entire marginated pool of neutrophils, and the neutrophil half-life was extended from a normal of 6.6 hours to 10.4 hours by cortisol. Chemotaxis after six hours of epinephrine infusion was reduced compared with baseline chemotaxis. In four volunteers who had a second infusion of cortisol, chemotaxis was significantly depressed ten days after the infusion compared with baseline. From these data we conclude that stress levels of epinephrine mobilize the marginated pool of granulocytes into the circulating pool in a linear fashion, and cortisol raises the half-life of circulating neutrophils. Reduced neutrophil chemotaxis seen as a consequence of these infusions could account for some of the increased susceptibility to infection that occurs after major trauma. PMID:2056538

Davis, J M; Albert, J D; Tracy, K J; Calvano, S E; Lowry, S F; Shires, G T; Yurt, R W

1991-06-01

251

Albumin infusion in humans does not model exercise induced hypervolaemia after 24 hours  

Science.gov (United States)

We rapidly infused 234 +/- 3 mL of 5% human serum albumin in eight men while measuring haematocrit, haemoglobin concentration, plasma volume (PV), albumin concentration, total protein concentration, osmolality, sodium concentration, renin activity, aldosterone concentration, and atrial natriuretic peptide concentration to test the hypotheses that plasma volume expansion and plasma albumin content expansion will not persist for 24 h. Plasma volume and albumin content were expanded for the first 6 h after infusion (44.3 +/- 1.9-47.2 +/- 2.0 mL kg-1 and 1.9 +/- 0.1-2.1 +/- 0.1 g kg-1 at pre-infusion and 1 h, respectively, P plasma volume and albumin content decreased significantly from 1 h post-infusion and were not different from pre-infusion (44.8 +/- 1.9 mL kg-1 and 1.9 +/- 0.1 g kg-1, respectively). Plasma aldosterone concentration showed a significant effect of time over the 24 h after infusion (P plasma volume and 10.5% expansion of plasma albumin content by infusion does not remain in the vascular space for 24 h and suggest a redistribution occurs between the intravascular space and interstitial fluid space.

Haskell, A.; Gillen, C. M.; Mack, G. W.; Nadel, E. R.

1998-01-01

252

Transfer of difenoconazole and azoxystrobin residues from chrysanthemum flower tea to its infusion.  

Science.gov (United States)

Investigations of the transfer of pesticide residues from tea to its infusion can be important in the assessment of the possible health benefits of tea consumption. In this work the transfer of difenoconazole and azoxystrobin residues from chrysanthemum tea to its infusion was investigated at different water temperatures, infusion intervals and times. The transfer percentages were in the range of 18.7-51.6% for difenoconazole and of 38.1-71.2% for azoxystrobin, and increased considerably with longer infusion intervals. The results indicated that azoxystrobin with a lower octanol-water partition coefficient of 2.5, showed a higher transfer than that of difenoconazole with a relatively high octanol-water partition coefficient of 4.4. Water temperature had no significant effect on the transfer of the two residues, and no obvious loss of difenoconazole and azoxystrobin occurred during the infusion process. The concentrations in the infusions decreased gradually from 0.67 to 0.30 ?g kg(-1) for difenoconazole and from 2.3 to 0.46 ?g kg(-1) for azoxystrobin after five infusions. To assess the potential health risk, the values of estimate expose risk were calculated to be 0.016 for difenoconazole and 0.0022 for azoxystrobin, meaning the daily residue intake of the two analytes from chrysanthemum tea was safe. This research may help assure food safety and identify the potential exposure risks from pesticides in chrysanthemum that may be health concerns. PMID:24405376

Xue, Jiaying; Li, Huichen; Liu, Fengmao; Xue, Jian; Chen, Xiaochu; Zhan, Jing

2014-04-01

253

Prophylactic fibrinogen infusion reduces bleeding after coronary artery bypass surgery. A prospective randomised pilot study.  

Science.gov (United States)

It has been suggested that preoperative fibrinogen plasma concentration is independently associated to postoperative blood loss after cardiac surgery. Theoretically, prophylactic infusion of fibrinogen concentrate may thus reduce postoperative bleeding, but this has not previously been investigated. Twenty elective coronary artery bypass graft (CABG) patients with preoperative plasma fibrinogen levels FIB group) or no infusion before surgery (control group). Primary endpoint was safety with clinical adverse events and graft occlusion assessed by multi-slice computed tomography. Predefined secondary endpoints were postoperative blood loss, blood transfusions, haemoglobin levels 24 hours (h) after surgery, and global haemostasis assessed with thromboelastometry, 2 and 24 hours after surgery. Infusion of 2 g fibrinogen concentrate increased plasma levels of fibrinogen by 0.6 +/- 0.2 g/l. There were no clinically detectable adverse events of fibrinogen infusion. Computed tomography revealed one subclinical vein graft occlusion in the FIB group. Fibrinogen concentrate infusion reduced postoperative blood loss by 32% (565 +/- 150 vs. 830 +/- 268 ml/12 h, p=0.010). Haemoglobin concentration was significantly higher 24 h after surgery in the FIB group (110 +/- 12 vs. 98 +/- 8 g/l, p=0.018). Prophylactic fibrinogen concentrate infusion did not influence global postoperative haemostasis as assessed by thromboelastometry. In conclusion, in this pilot study preoperative fibrinogen concentrate infusion reduced bleeding after CABG without evidence of postoperative hypercoagulability. Larger studies are necessary to ensure safety and confirm efficacy of prophylactic fibrinogen treatment in cardiac surgery. PMID:19572078

Karlsson, Martin; Ternström, Lisa; Hyllner, Monica; Baghaei, Fariba; Flinck, Agneta; Skrtic, Stanko; Jeppsson, Anders

2009-07-01

254

Effects of glucagon infusions on protein and amino acid composition of milk from dairy cows.  

Science.gov (United States)

Changing the composition of milk proteins and AA affects the nutritional and physical properties of dairy products. Intravenous infusions of glucagon decreases milk protein production and concentration by promoting the use of gluconeogenic blood AA for hepatic glucose synthesis. Little is known about how the diversion of AA to gluconeogenesis affects the composition of milk proteins and AA. The objective was to quantify changes in composition of milk protein and AA in response to i.v. glucagon infusions. Three separate experiments were used: 1) 8 Holstein cows were fed ad libitum and infused with glucagon at 10 mg/d for 14 d, 2) 7 Holstein cows were feed restricted and infused with glucagon at 10 mg/d for 14 d, and 3) 4 Brown Swiss cows were infused with glucagon at 5 and 10 mg/d for 2 d each. Milk and milk component yields and milk protein and amino acid composition of samples, collected with blood samples at the first and last day of the glucagon infusion period, were compared with those collected 1 d before and after the glucagon infusion period. Glucagon infusions decreased milk protein production and concentration in each experiment by at least 0.2 +/- 0.05 kg/d and 4 +/- 0.4 g/L, respectively. The decrease was accompanied by changes in milk protein composition, the most consistent being an increase in kappa-casein (1.68 +/- 0.27%). Overall, glucagon infusions resulted in higher proportions of kappa-casein and alpha(S2)-casein (1.34 +/- 0.51%) and smaller proportions of alpha(S1)-casein (-3.83 +/- 1.75%) and alpha-lactalbumin (-0.91 +/- 0.32%). Glucagon had little impact on milk AA composition except an increase in glycine (0.26 +/- 0.11%). The results suggest that milk protein synthesis is regulated by many factors including AA and glucose availability. PMID:19109271

Bobe, G; Hippen, A R; She, P; Lindberg, G L; Young, J W; Beitz, D C

2009-01-01

255

ANG II infusion promotes abdominal aortic aneurysms independent of increased blood pressure in hypercholesterolemic mice  

OpenAIRE

Infusion of ANG II in hyperlipidemic mice augments atherosclerosis and causes formation of abdominal aortic aneurysms (AAAs). The purpose of this study was to define the contribution of ANG II-induced hypertension to these vascular pathologies. Male apolipoprotein E (apoE)- and LDL receptor (LDLr)-deficient mice were infused with ANG II (1,000 ng·kg?1·min?1) or norepinephrine (NE; 5.6 mg·kg?1·day?1) for 28 days. Infusion of ANG II or NE increased mean arterial pressure (MAP; ANG I...

Cassis, Lisa A.; Gupte, Manisha; Thayer, Sarah; Zhang, Xuan; Charnigo, Richard; Howatt, Deborah A.; Rateri, Debra L.; Daugherty, Alan

2009-01-01

256

Changes in circulating blood volume after infusion of hydroxyethyl starch 6% in critically ill patients  

DEFF Research Database (Denmark)

The cardiovascular response to a volume challenge with hydroxyethyl starch (HES) (200/0.5) 6% depends on the relation between the volume of HES 6% infused and the expansion of the blood volume in critically ill patients. However, only relatively limited data exist on the plasma expanding effect of infusion of HES 6% in critically ill patients. The purpose of the study was to evaluate the variation in the expansion of the circulating blood volume (CBV) in critically ill patients after infusion of 500 ml of colloid (HES (200/0.5) 6%) using the carbon monoxide method.

Christensen, P; Andersson, J

2001-01-01

257

Infusion tomography and ultrasonography of the gallbladder in the diagnosis of acute cholecystitis  

International Nuclear Information System (INIS)

Sixty-three patients with the clinical suspicion of acute cholecystitis were examined with infusion tomography of the gallbladder. Ultrasonography was performed in 51 of these cases. The technique and diagnostic principles of both methods are discussed. The diagnostic value of the two methods when used in combination is stressed. Thus in a case of gangrenous cholecystitis when opacification of the gallbladder wall may not appear at infusion tomography, ultrasonography may demonstrate signs of gallbladder disease. Infusion tomography, on the other hand, may be of great value if ultrasonography is not informative. (orig.) 891 AJ/orig. 892 BRE

258

[Selective intraarterial infusion chemotherapy using a combined MRI-angiography system for head and neck cancers].  

Science.gov (United States)

We performed selective intraarterial infusion chemotherapy using a combined MRI-angiography system for head and neck cancers. In three patients, three or five infusions of CDDP (100 mg/body) were administered to the feeding arteries selectively. For the evaluation of drug distribution, MRI during arteriography through the infusion pump was performed before CDDP administration. When a distribution mismatch was found, arterial selection was attempted again under a mechanically unstable C-arm system, and further evaluation under an MR system was carried out. Thus, more ideal treatment could be provided. We consider MRI during arteriography to be useful in assessing for distribution during intraarterial chemotherapy. PMID:11857953

Mori, Harushi; Hayashi, Naoto; Aoki, Shigeki; Masumoto, Tomohiko; Yoshikawa, Takeharu; Abe, Osamu; Ohtomo, Kuni; Yuge, Tadashi; Kaga, Kimitaka

2002-01-01

259

Treatment of lung cancer with bronchial artery infusion of cisplatin and intravenous sodium thiosulfate rescue  

International Nuclear Information System (INIS)

Forty-nine patients with primary lung cancer were treated with bronchial artery infusion of cisplatin and intravenous injection of an antidote, sodium thiosulfate. More than 50% reduction of tumor size (PR) was observed in 8 of 9 small cell carcinomas (SCLC) and in 16 of 40 non-small cell carcinomas (NSCLC). In NSCLC patients PR was obtained in 71% (12/17) after repeated infusions (? 200 mg cisplatin) and in 17% (4/23) after a single infusion (? 150 mg cisplatin). There was a significant linear relationship between cisplatin dose and tumor reduction in this group. No severe adverse effects were encountered. (orig.)

260

Sub-Acute Toxicity Studies of Paracetamol Infusion in Albino Wistar Rats  

Directory of Open Access Journals (Sweden)

Full Text Available The objective of the present study was to evaluate the sub-acute toxicity of paracetamol infusion in albino wistar rats (male and female at different dose levels, ranging from 16 to 66 mg/kg body weight. No mortality was seen in any of the treatment groups during the course of study. Various physiological, hematological as well as biochemical parameters were studied and found not to be changed significantly, indicating that paracetamol infusion is non toxic even at higher dose level in wistar rats. Overall safety and tolerability profile of paracetamol infusion is proved good and does not appear to carry risk of serious adverse effects.

Anurag Payasi

2010-04-01

261

Technical Sections  

International Nuclear Information System (INIS)

Full text: 1. Detector Construction Laboratory for High Energy Physics. Head: Marek Stodulski, Ph.D., Deputy: Jacek Blocki, Ph.D. Eng. Personnel of 4 research staff members and 9 technical staff . Main subject of activity: design and construction of mechanical structures and cooling systems applied in high energy physics experiments. Includes research, development, prototyping and tests. Presently involved in the installation of the ATLAS experiment and the LHC machine at CERN and in the design of new detectors (ICARUS, CASTOR and LUMICAL) at IFJ PAN. Also, research and development of new materials, such as carbon-carbon (C/C) composites. 2. Mechanical Engineering Section. Head: Jerzy Brzezicki, M.Sc. Eng., Deputy: Krzysztof Wisniewski, M.Sc. Eng. Personnel of 22 people. Activity: design and production of scientific apparatus. Construction of versatile equipment, including, e.g. electrically driven lock in the shield and automatic targets for beam diagnostics for the AIC-144 cyclotron, mechanisms supporting thermoluminescent readers (EU project MAESTRO), design and construction of an equipment for production of elements for ICARUS neutrino experiment (Gran Sasso), and series of equipment constructed for CERN i.e.: periscope instruments for visual inspection of LHC beam (6 items), optical tool for verification of LHC magnet transverse alignment before interconnection (1 item), line N protection covers (100 items), line N handling assembly (100 items), cooling system sung assembly (100 items), cooling system support (500 items), final production of the series of stesalite elements (? 100 items) for the cooling system of ATLAS experiment. 3. The Cyclotron Division. Head: Jacek Sulikowski, M.Sc. Personnel: 2 research staff members and 14 people of technical staff . Main subject of activity: modernization of the AIC-144 IFJ PAN cyclotron and its adaptation for medical purposes (proton/neutron radiotherapy, production of radioisotopes).Th is program includes extraction of 60 MeV proton and hellions and 30 MeV deuteron beams, purchase, installation and putting into operation of the new magnet power supply and the new PIG ion source. During last two years period we completed the modernization of the experimental hall No.1 and rebuilt the system of the beam transport lines. The proton beam was delivered to the box for an eye melanoma treatment. We have also continued the efforts on the analytical computer programme HELP for the calculation of main parameters of the beam dynamics (in cooperation with JINR Dubna). (author)

262

Hemolytic uremic syndrome following the infusion of oxaliplatin: case report  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Oxaliplatin is a platinum derivative, which is used in the treatment of colorectal cancer. A small number of oxaliplatin-related hemolytic and/or thrombocytopenic reactions have been reported. We present a case of hemolytic-uremic syndrome that developed during the 4th cycle of combination chemotherapy with oxaliplatin, 5-fluorouracil and leucovorin. Case presentation A 52-year-old-male was administered chemotherapy with oxaliplatin, 5-fluorouracil and leucovorin for a Duke's stage C colorectal carcinoma. Three cycles of chemotherapy had been administered without complications when, at the beginning of the fourth cycle, the patient developed clinical and laboratory abnormalities consistent with the development of the hemolytic-uremic syndrome. Treatment was discontinued; the patient was managed with monitored IV hydration and loop diuretics, high dose corticosteroids and fresh frozen plasma infusions and recovered completely. Conclusion The hemolytic-uremic syndrome may be a rare complication of oxaliplatin-based chemotherapy. Clinicians need to maintain a high index of suspicion to diagnose and treat this life-threatening adverse event.

Tseligas Dimitrios

2006-09-01

263

Adverse events with continuous doxapram infusion against late postoperative hypoxaemia.  

DEFF Research Database (Denmark)

OBJECTIVE: A randomized double-blind controlled trial of doxapram versus placebo against late postoperative hypoxaemia was planned to include 40 patients (2 x 20). RESULTS: After inclusion of 18 patients a serious adverse event was encountered with development of a brain stem infarction in a 90-year-old woman receiving doxapram. At this point the randomization code was broken and we decided to terminate the trial. Three of nine patients receiving doxapram had had an adverse event whereas none of the patients receiving placebo had adverse events (P = 0.2). In the 18 patients studied, there was an insignificant trend towards higher mean oxygen saturation in the doxapram group, and a significantly higher minimum oxygen saturation and reduced number of hypoxaemic events on the first postoperative night. CONCLUSION: Although these preliminary data on the effect of doxapram on postoperative hypoxaemia seem promising, further studies on the effect of continuous nocturnal postoperative doxapram infusion on levels of arterial oxygen saturation should be postponed until more knowledge about the pharmacokinetics of doxapram in this particular clinical situation has been gathered.

Rosenberg, J; Kristensen, P A

1996-01-01

264

Hepatic Arterial Infusion Chemotherapy for Advanced Hepatocellular Carcinoma in Japan  

Directory of Open Access Journals (Sweden)

Full Text Available Transcatheter methods such as transcatheter arterial chemoembolization (TACE and hepatic arterial infusion chemotherapy (HAIC have an important role in the treatment for advanced hepatocellular carcinoma (HCC. Recently, sorafenib, an inhibitor of tyrosine kinases, has been found to obtain survival benefits in patients with HCC, leading to major advances in the treatment of advanced HCC. However, it is associated with a low tumor response rate, minimal survival advantage, and high rates of adverse events. On the other hand, high rates of objective treatment response with HAIC for advanced HCC have been reported, although convincing evidence of it contributing to overall survival in HAIC has been lacking. In Japan, HAIC still tends to be the preferred method for the treatment of advanced HCC, even in patients with poor liver function. However, the choice of chemotherapeutic agents in TACE/HAIC for HCC varies between institutions. In this review, based on studies reported to date in the literature, we refer to current knowledge regarding the chemotherapeutic agents used for TACE/HAIC for HCC in Japan and consider the future perspectives for HAIC for this cancer.

Ryuichi Kita

2012-02-01

265

Radiation resistance of microorganisms on unsterilized infusion sets  

DEFF Research Database (Denmark)

Three different methods were used for detecting and isolating microorganisms with high radiation resistance from the microbial contamination on infusion sets prior to sterilization. By all three methods, microorganisms with a radiation resistance high enough to be a critical factor in a sterilization process (D-6 value greater-than-or-equal-to 30 kGy) were found with a frequency of approximately two colony forming units (cfu) per 100 product items, even though the product items in two of the series of analyses were irradiated with doses of 3-6 kGy. The frequency of occurrence of isolates with D-6 values greater-than-or-equal-to 30 kGy was 0.45 per 1000 cfu of the total aerobic count. Eight different isolates of microorganisms had D-6 values greater-than-or-equal-to 40 kGy when irradiated in dried laboratory preparation. All but one of these were classified according to morphologic criteria as Deinococcus, and all but one had nonlinear dose-response relationships in semilogarithmic presentation.

Christensen, E. Ahrensburg; Kristensen, H.

1991-01-01

266

Incidence and management of infusion reactions to infliximab in 186 italian patient’s with rheumatoid arthritis: the Padua experience  

Directory of Open Access Journals (Sweden)

Full Text Available Objective: We report the incidence and treatment of infusion reactions to infliximab, a chimeric monoclonal IgG1 antibody against tumor necrosis factor a, in a large cohort of patients with rheumatoid arthritis. Patients and methods: One hundred eighty six patients with rheumatoid arthritis treated with infliximab for a total of 216.6 patient years were retrospectively evaluated. Patients received 2160 infliximab infusions at the Division of Rheumatology at the University Hospital of Padua from May, 2000 to April, 2004. Specific treatment protocols for initial and subsequent acute infusion reactions were followed and the outcomes documented. Results: The overall incidence of infusion reactions to infliximab was 0.8% (19 out of 2160 of infusions, affecting 10.2% of patients (19 out of 186. Mild, moderate, or severe acute reactions occurred in 0.1% (3 of 2160, 0.6% (13 of 2160, and 0.04% (1 of 2160 of infliximab infusions, respectively. Delayed infusion reactions occurred in 0.09% (2 of 2160 of infusions. Use of specific treatment protocols resulted in rapid resolution of all acute reactions to infliximab. With a prophylaxis protocol, all patients who experienced an initial mild acute reaction were able to receive additional infusions. Conclusions: Using appropriate treatment protocols, infliximab infusion reactions were effectively treated and prevented in patients with mild acute reactions upon retreatment. In the case of moderate to severe infusion reactions, the risks and the benefits of the continuation of infliximab therapy need to be carefully considered.

S. Todesco

2011-09-01

267

Anti-peroxyl radical quality and antibacterial properties of rooibos infusions and their pure glycosylated polyphenolic constituents.  

Science.gov (United States)

The anti-peroxyl radical quality of two aqueous rooibos infusions and solutions of their most abundant glycosylated polyphenols was evaluated using pyrogallol red and fluorescein-based oxygen radical absorbance ratios. It was observed that the artificial infusions, prepared using only the most abundant polyphenols present in rooibos and at concentrations similar to those found in the natural infusions, showed greater antioxidant quality than the latter infusions, reaching values close to those reported for tea infusions. Additionally, the antimicrobial activity of the natural and artificial infusions was assessed against three species of bacteria: Gram (+) Staphylococus epidermidis and Staphylococcus aureus and Gram (-) Escherichia coli. When compared to the natural infusions the artificial beverages did not demonstrate any bacterostatic/cidal activity, suggesting that the antibacterial activity of rooibos is related to compounds other than the glycosylated polyphenols employed in our study. PMID:24036515

Simpson, Madeline J; Hjelmqvist, Daisy; López-Alarcón, Camilo; Karamehmedovic, Nadja; Minehan, Thomas G; Yepremyan, Akop; Salehani, Baback; Lissi, Eduardo; Joubert, Elizabeth; Udekwu, Klas I; Alarcon, Emilio I

2013-01-01

268

Anti-Peroxyl Radical Quality and Antibacterial Properties of Rooibos Infusions and Their Pure Glycosylated Polyphenolic Constituents  

Directory of Open Access Journals (Sweden)

Full Text Available The anti-peroxyl radical quality of two aqueous rooibos infusions and solutions of their most abundant glycosylated polyphenols was evaluated using pyrogallol red and fluorescein-based oxygen radical absorbance ratios. It was observed that the artificial infusions, prepared using only the most abundant polyphenols present in rooibos and at concentrations similar to those found in the natural infusions, showed greater antioxidant quality than the latter infusions, reaching values close to those reported for tea infusions. Additionally, the antimicrobial activity of the natural and artificial infusions was assessed against three species of bacteria: Gram (+ Staphylococus epidermidis and Staphylococcus aureus and Gram (? Escherichia coli. When compared to the natural infusions the artificial beverages did not demonstrate any bacterostatic/cidal activity, suggesting that the antibacterial activity of rooibos is related to compounds other than the glycosylated polyphenols employed in our study.

Klas I. Udekwu

2013-09-01

269

Variation of the intercellular space in the esophageal epithelium in response to hydrochloridric acid infusion in patients with erosive esophagitis  

Directory of Open Access Journals (Sweden)

Full Text Available The purpose of this study was to compare esophageal infusion with 0.1 N hydrochloridric acid (HCl to esophageal infusion with saline in patients presenting with typical gastroesophageal reflux symptoms and erosive esophagitis. METHODS: Upper gastrointestinal endoscopy was performed on 44 prospective subjects, 29 of whom were included in the study. Eighteen patients presented with normal esophagi (Control Group "C", nine of whom were infused with HCl and nine with saline. Eleven patients presented with erosive esophagitis (Lesion Group "L", five of whom were infused with HCl and six with saline. Biopsies of the esophageal mucosa were collected before and after infusions. RESULTS: No statistically significant difference was found between the two types of infusions in terms of the dilation of the intercellular space of the esophageal epithelium, regardless of the status of the patient. CONCLUSIONS: Response to HCl infusion cannot be used as a marker for gastroesophageal reflux disease.

Ricardo Tedeschi Matos

2009-01-01

270

In vitro study of the antioxidant and immunomodulatory activity of aqueous infusion of Bidens pilosa.  

Science.gov (United States)

Bidens pilosa is an annual plant from tropical America with anti-inflammatory properties in hepatitis, laryngitis, headache and digestive disorders, among others. Its wide pharmacological applications can be attributed to its chemical composition, with inhibitory effects on pathogenic microorganisms and flavonoids, which show strong antioxidant capacities. We investigated the antioxidant activity of an aqueous infusion of Bidens pilosa by studying its protective effect on the hemolysis induced by an initiator of radicals such as 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH). The immunomodulatory activity of the infusion was tested using whole blood cells. Cytokine production increased in whole blood stimulated or not by lipopolysaccharides (LPSs). The infusion is also characterized by its capacity to protect erythrocytes from the phototoxic effect of chlorpromazine, which allows its use as a potential photoprotector. Finally, it did not show ocular irritation, as demonstrated by the effect on hemoglobin denaturation. This study supports the health benefits of the ingestion of the infusion. PMID:15234771

Abajo, Celia; Boffill, María Angeles; del Campo, Jaime; Alexandra Méndez, María; González, Yisel; Mitjans, Montserrat; Pilar Vinardell, María

2004-08-01

271

A new venous infusion path monitoring system utilizing electrostatic induced potential.  

Science.gov (United States)

A new venous infusion pathway monitoring system has been developed for hospital and home use. The system consists of linear and digital integrated circuits and a low-power 8-bit single chip microcomputer which constantly monitors the infusion pathway intactness. A 330 kHz AC voltage, which is induced on the patient's body by electrostatic coupling from a 330 kHz pulse oscillator, can be recorded by main and reference electrodes wrapped around the infusion polyvinyl chloride tube. If the injection needle or infusion tube becomes detached, then the system detects changes in the induced AC voltages and alerts the nursing station, via the nurse call system or PHS (personal handy phone system). PMID:19163413

Ogawa, Hidekuni; Yonezawa, Yoshiharu; Maki, Hiromichi; Caldwell, W Morton

2008-01-01

272

75 FR 12760 - Determination That CERNEVIT-12 (Multivitamins for Infusion) Was Withdrawn From Sale for Reasons...  

Science.gov (United States)

...multivitamins for infusion (retinol palmitate corresponding to retinol (Vitamin A) 3500 international units (I.U.), cholecalciferol (Vitamin D 3 ) 200 I.U., DL alpha-tocopherol 10.2 milligrams (mg) corresponding to...

2010-03-17

273

Decoction, infusion and hydroalcoholic extract of Origanum vulgare L.: different performances regarding bioactivity and phenolic compounds.  

Science.gov (United States)

Bioactivity of oregano methanolic extracts and essential oils is well known. Nonetheless, reports using aqueous extracts are scarce, mainly decoction or infusion preparations used for therapeutic applications. Herein, the antioxidant and antibacterial activities, and phenolic compounds of the infusion, decoction and hydroalcoholic extract of oregano were evaluated and compared. The antioxidant activity is related with phenolic compounds, mostly flavonoids, since decoction presented the highest concentration of flavonoids and total phenolic compounds, followed by infusion and hydroalcoholic extract. The samples were effective against gram-negative and gram-positive bacteria. It is important to address that the hydroalcoholic extract showed the highest efficacy against Escherichia coli. This study demonstrates that the decoction could be used for antioxidant purposes, while the hydroalcoholic extract could be incorporated in formulations for antimicrobial features. Moreover, the use of infusion/decoction can avoid the toxic effects showed by oregano essential oil, widely reported for its antioxidant and antimicrobial properties. PMID:24731316

Martins, Natália; Barros, Lillian; Santos-Buelga, Celestino; Henriques, Mariana; Silva, Sónia; Ferreira, Isabel C F R

2014-09-01

274

Intra-arterial Infusion of Leptin does not Affect Blood Pressure in Salt-loaded Rabbits  

Directory of Open Access Journals (Sweden)

Full Text Available The aim of this research is to see the effect of intra-arterial infusion of leptin on blood pressure of salt loaded rabbits in vivo. Increased blood pressure was produced in rabbits by giving diets containing 8% sodium chloride for 5 weeks. Leptin in different concentrations was infused intra-arterially into rabbits fed on high salt diets and the response was compared in rabbits fed with low salt diets. High salt diets produced significant increase in blood pressure. In rabbits fed with low salt diet, leptin infused intra-arterially caused an increase in blood pressure while infusion of leptin into rabbits fed with high salt diets does not affect the blood pressure. In conclusion, salt loading to rabbits abolishes the effect of leptin on cardiovascular system. This may indicate that leptin effect on sympathetic activity is altered by high salt diets in these animals.

Mohammad Nidal Khabaz

2010-01-01

275

ACOG technology assessment in obstetrics and gynecology. Number 3, September 2003. Saline infusion sonohysterography.  

Science.gov (United States)

Saline infusion sonohysterography consists of ultrasonographic imaging of the uterus and uterocervical cavity, using real-time ultrasonography during injection of sterile saline into the uterus. When properly performed, saline infusion sonohysterography can provide information about the uterus and endometrium. The most common indication for sonohysterography is abnormal uterine bleeding. Sonohysterography should not be performed in a woman who is pregnant or who could be pregnant or in a woman with a pelvic infection or unexplained pelvic tenderness. Physicians who perform or supervise diagnostic saline infusion sonohysterography should have training, experience, and demonstrated competence in gynecologic ultrasonography and saline infusion sonohysterography. Portions of this document were developed jointly with the American College of Radiology and the American Institute of Ultrasound in Medicine. PMID:12962967

Breitkopf, Daniel; Goldstein, Steven R; Seeds, John W

2003-09-01

276

IPMC-assisted miniature disposable infusion pumps with embedded computer control  

Science.gov (United States)

For military applications, the availability of safe, disposable, and robust infusion pumps for intravenous fluid and drug delivery would provide a significant improvement in combat healthcare. To meet these needs, we have developed a miniature infusion prototype pump for safe and accurate fluid and drug delivery that is programmable, lightweight, and disposable. In this paper we present techniques regarding inter-digitated IPMCs and a scaleable IPMC that exhibits significantly improved force performance over the conventional IPMCs. The results of this project will be a low cost accurate infusion device that can be scaled from a disposable small volume liquid drug delivery patch to disposable large volume fluid resuscitation infusion pumps for trauma victims in both the government and private sectors of the health industry.

Vohnout, Sonia; Kim, Sang-Mun; Park, Il-Seok; Banister, Mark; Tiwari, Rashi; Kim, Kwang J.

2007-04-01

277

Altered hepatic vasopressin and alpha 1-adrenergic receptors after chronic endotoxin infusion  

International Nuclear Information System (INIS)

Sepsis and septic shock are complicated by a number of hemodynamic and metabolic aberrations. These include catecholamine refractoriness and altered glucose metabolism. Recently, a nonshock rat model of continuous endotoxin infusion via an implanted osmotic pump was developed that reproduces some of the metabolic and cardiovascular findings of human sepsis. By using this model, we have found a decreased number of hepatic plasma membrane alpha 1-adrenergic and [Arg8]vasopressin receptors in rats continuously infused with endotoxin. There was a significant decrease in [3H]prazosin (35 +/- 7%) and [3H] [Arg8]vasopressin (43 +/- 8%) receptors after 30 h of continuous endotoxin infusion with no change in affinity. The ability of norepinephrine to form the high-affinity complex with alpha 1-adrenergic receptors was not altered after chronic endotoxin infusion. The results are consistent with the concept that alterations in receptor number might underlie certain of the metabolic consequences of chronic sepsis

278

A technique of infusion of contrast material on CT enhancement study  

International Nuclear Information System (INIS)

We have studied the method of enhancement on a fast CT scanner of the third generation by changing the infusion time of contrast material, 3 min., 5 min. and 7 min., and by measuring the attenuation values of certain ROIs at 1 min., 3 min. and 5 min. after infusion. 60% meglumine iothalamate and 65% meglumine diatrizoate were compared in their enhancing effect and side effects. There was no difference in the enhancing effect between the two contrast materials, but 60% meglumine iothalamate had less side effect than the other. The longer the infusion time, the less the side effects, especially nausea and vomiting. We have come to the conclusion that 7 min. infusion of 100 ml of 60% meglumine iothalamate is the method of choice for contrast enhancement CT scan. (author)

279

Hemodynamic effects of rapid and slow infusions of manganese chloride and gadolinium-DTPA in dogs  

International Nuclear Information System (INIS)

The acute hemodynamic effects of two paramagnetic contrast materials, manganese chloride and gadolinium-DTPA, were examined in dogs using ultrasonic dimension gauge crystals. Slow infusions (more than 15 minutes) of MnCl2 or Gd-DTPA via an infusion pump had no significant hemodynamic effects. When given in just over 1 minute, Gd-DTPA produced elevated left ventricular (LV) end diastolic pressure and minor dilation of the ventricle and slowed diastolic filling. MnCl2, given rapidly, reduced systemic vascular resistance, resulting in hypotension. With both agents, these side effects waned after 5-10 minutes. It is concluded that both Gd-DTPA and MnCl2 can be given safely in 0.1-mm/kg doses when administered as a slow, continuous infusion. Slow, intravenous infusion of Gd-DTPA or MnCl2 is likely to be tolerated well by even severely ill individuals

280

21 CFR 526.464b - Cloxacillin benzathine for intramammary infusion, sterile.  

Science.gov (United States)

...mastitis caused by Staphylococcus aureus and Streptococus...used for human food. Animals infused...slaughtered for food from the time...agalactiae and Staphylococcus aureus. (3) Limitations...slaughtered for food use for 4...

2010-04-01

281

Efficacy of Synthetic Insecticide and Botanical Infusions Against Onion Thrips in Balochistan, Pakistan-I  

Directory of Open Access Journals (Sweden)

Full Text Available A synthetic insecticide (Monocrotophos 40WSL and three botanical infusions (Datura alba Seed Extract Infusion, SEI; Calotropis procera Latex Infusion, LI and Citrullus colocynthus Fruit Extract Infusion, FEI were tried against onion thrips on broadcasted onion variety “Chlitan 89” in Quetta, Pakistan. All tested insecticides caused mortality of onion thrips at various degrees of significance over untreated control. C. procera LI, proved it self the best among the tested botanical insecticides and provided 42.67 % control after Monocrotophos that caused 76.24 % mortality of onion thrips. D. alba SEI and C. colocynthus FEI showed minimal control (17.23 and 6.77 % respectively of the said pest than other tested insecticides but the results encourage the idea of pollution free methods of pest control. The C. procera LI can be used as good as any other botanical insecticide in Integrated Pest Management (IPM of onion thrips.

Muhammad Faheem Malik

2003-01-01

282

Aktifitas Penangkapan Radikal Bebas dari Infus Kelopak Bunga Rosella Yang difermentasi dengan Lactobacillus  

OpenAIRE

Penelitian ini bertujuan untuk mengetahui aktivitas penangkapan radikal bebas dari fraksi etil asetat infuse kelopak bunga rosella (hibiscus sabdariffa L.) yang difermentasi dengan Lactobacillus casei strain shirota terhadap radikal bebas DPPH (2,2-diphenyl-2-picrylhydrazyl). Kelopak bunga rosella diekstraksi dengan cara infudasi dengan konsentrasi 5% b/v. Infus yang diperoleh difermentasi menggunakan kultur Lactobacillus casei strain Shirota dengan lama inkubasi 3 x 24 jam suhu 37???C. Hasil...

Sartini; Lethe, Christiana; Frengky

2014-01-01

283

Lack of antibacterial activity after intravenous hydrogen peroxide infusion in experimental Escherichia coli sepsis.  

OpenAIRE

The intravenous administration of hydrogen peroxide has been reported to benefit patients with pneumonia and to reduce Plasmodium parasitemia in experimentally infected mice. We assessed the antibacterial activity of intravenously infused hydrogen peroxide against hydrogen peroxide-susceptible Escherichia coli (MBC of hydrogen peroxide, 0.23 mM) in experimentally infected rabbits. No decrease in the level of bacteremia was detected at the maximum intravenous infusion rate of hydrogen peroxide...

Shenep, J. L.; Stokes, D. C.; Hughes, W. T.

1985-01-01

284

Effect of boldo (Peumus boldus Molina) infusion on lipoperoxidation induced by cisplatin in mice liver.  

Science.gov (United States)

Peumus boldus Molina (Monimiaceae), commonly referred to as 'boldo', is used in traditional Chilean medicine to treat hepatic and gastrointestinal diseases. Its leaves are rich in antioxidant compounds, principally alkaloids and flavonoids. This study evaluates the protective effect of a complete boldo leaf infusion on lipoperoxidation (MDA determination at 532 nm) induced by cisplatin in mice liver. To determine if the observed effect can be explained by the action of boldine or catechin, each compound was studied separately. The mice were divided into 8 groups (n = 6): (I) not treated; (II) treated with cisplatin 6 mg/Kg b.w.; (III) treated with boldo leaf infusion 5%; (IV) pretreated with boldo leaf infusion 5% and treated with cisplatin 6 mg/Kg b.w.; (V) treated with boldine 50 mg/Kg b.w.; (VI) pretreated with boldine 50 mg/Kg b.w. and treated with cisplatin 6 mg/kg.b.w.; (VII) treated with catechin; and (VIII) pretreated with catechin 50 mg/Kg b.w. and treated with cisplatin 6 mg/Kg b.w. As expected, the treatment with cisplatin significantly increased (p < 0.01) lipoperoxidation in comparison with the non-treated group. Pretreatment with boldo leaf infusion significantly diminished (p < 0.05) the lipoperoxidation induced by cisplatin with respect to the animals not pretreated with the infusion. The pretreatments with boldine and catechin significantly diminished (p < 0.05) the lipoperoxidation induced by cisplatin with respect to the group treated only with cisplatin. The results suggest that the boldo infusion is acting as a protector with respect to the oxidative hepatic damage caused by cisplatin, and that this protective ability would be due to the presence in the infusion of the natural antioxidants boldine and principally catechin. These findings suggest the potential use of the infusion as a chemoprotector. PMID:19145575

Fernández, J; Lagos, P; Rivera, P; Zamorano-Ponce, E

2009-07-01

285

Plasma Calcium, Inorganic Phosphate and Magnesium During Hypocalcaemia Induced by a Standardized EDTA Infusion in Cows  

OpenAIRE

The intravenous Na2EDTA infusion technique allows effective specific chelation of circulating Ca2+ leading to a progressive hypocalcaemia. Methods previously used were not described in detail and results obtained by monitoring total and free ionic calcium were not comparable due to differences in sampling and analysis. This paper describes a standardized EDTA infusion technique that allowed comparison of the response of calcium, phosphorus and magnesium between 2...

Jmd, Enemark; Rj, Jørgensen; Lsb, Mellau

2001-01-01

286

Thrombotic thrombocytopenic purpura following zoledronic acid infusion with a fatal outcome  

OpenAIRE

A 56-year-old woman presented with generalised bone pain with bone mineral density showing severe osteoporosis for which she received a single 4 mg infusion of zoledronic acid (ZA). On the second day following the infusion, she developed fever with altered sensorium. A complete blood count showed anaemia and thrombocytopenia with peripheral blood smear repeatedly showing schistocytes, anisopoikilocytes and target cells. Serum biochemistry revealed elevation of serum creatinine at 1.5 mg/dl. I...

Bhadada, Sanjay K.; Bhansali, Anil; Das, Sambit; R, Ananthraman; Rao, Sudhakar D.

2009-01-01

287

Suppression of 3rd Ventricular NPY-Elicited Feeding Following Medullary Reticular Formation Infusions of Muscimol  

Science.gov (United States)

The appetitive component of feeding is controlled by forebrain substrates but the consummatory behaviors of licking, mastication and swallowing are organized in the brainstem. The target of forebrain appetitive signals is unclear but likely includes regions of the medullary reticular formation (RF). The present study was undertaken to determine the necessity of different RF regions for mastication induced by a descending appetitive signal. We measured solid food intake in response to third ventricular (3V) infusions of the orexigenic peptide, neuropeptide Y 3-36 in awake, freely-moving rats and determined whether focal RF infusions of the GABAA agonist muscimol suppressed eating. Reticular formation infusions were centered in either the lateral tegmental field, comprised of the intermediate (IRt) and parvocellular (PCRt) RF, or in the nucleus gigantocellularis (Gi). Infusions of NPY 3-36 (5 ug/5ul) into 3V significantly increased feeding of solid food over a 90 minute period compared to the non-infused condition (4.3 ± 0.56 versus 0.57 ± 0.57g, p < .001). NPY 3-36 induced food intake was suppressed (1.7g ± 0.48) by simultaneous infusions of muscimol (0.6 mM/100 nl) into the IRt/PCRt (p < .01). Coincident with the decrease in feeding was a decrease in the amplitude of anterior digastric muscle contractions in response to intra-oral sucrose infusions. In contrast, infusions of muscimol into Gi had no discernible effect on food intake or EMG amplitude. These data suggest that the IRt/PCRt is essential for forebrain-initiated mastication but that the Gi is not a necessary link in this pathway. PMID:20364882

Travers, Joseph B.; Herman, Kenneth; Travers, Susan P.

2010-01-01

288

Sensitization to methyl methacrylate in the plastic catheter of an insulin pump infusion set  

OpenAIRE

Cases of allergic contact dermatitis due to acrylics in the adhesive used to attach the needle to the tubing have previously been reported in pump infusion set users, but never previously due to an acrylic in the plastic tubing itself, as in this case. The presence of methyl methacrylate demonstrated in the catheter of the patient’s own infusion set correlated with her positive patch test results. Since patch testing and chemical-physical analysis was negati...

Saccabusi, Stanislao; Boatto, Gianpiero; Asproni, Battistina; Pau, Amedeo

2001-01-01

289

Critical Success Factors in The Infusion of Instructional Technologies for Open Learning in Development Settings  

OpenAIRE

This article seeks to identify critical success factors for the appropriate infusion of instructional technologies to advance open learning in higher education within developing settings. Describe here is a descriptive account of a two-year case study based on the author’s personal analysis of, and reflection on, factors that contributed to the infusion of instructional technologies to advance open learning at the University of Botswana. The first critical success factors identified in this...

Uys, Philip M.

2003-01-01

290

Chitosan-DNA nanoparticles delivered by intrabiliary infusion enhance liver-targeted gene delivery  

OpenAIRE

The goal of this study was to examine the efficacy of liver-targeted gene delivery by chitosan-DNA nanoparticles through retrograde intrabiliary infusion (RII). The transfection efficiency of chitosan-DNA nanoparticles, as compared with PEI-DNA nanoparticles or naked DNA, was evaluated in Wistar rats by infusion into the common bile duct, portal vein, or tail vein. Chitosan-DNA nanoparticles administrated through the portal vein or tail vein did not produce detectable luciferase expression. I...

Dai, Hui; Jiang, Xuan; Tan, Geoffrey Cy; Chen, Yong; Torbenson, Michael; Leong, Kam W.; Mao, Hai-quan

2006-01-01

291

Numerical modelling of a composite fuselage manufactured by liquid resin infusion  

OpenAIRE

FUSCOMP (FUSelage COMPosite) is a Research & Development program which has received the label from the Aerospace Valley competitiveness cluster. It will lead to a test of a composite fuselage demonstrator manufactured by the Liquid Resin Infusion (LRI) process. LRI is based on the moulding of high performance composite parts by infusing liquid resin on dry fibers instead of prepreg fabrics. The study of this proof of concept is based on the TBM 850 airframe, a pressurized business turboprop a...

Perret, Adrien; Mistou, Se?bastien; Denaud, Louis Etienne; Molle?, Thierry; Veyrac, Claudia; Karama, Moussa

2011-01-01

292

Rapid improvement of diffusion?weighted imaging abnormalities after glucose infusion in hypoglycaemic coma  

OpenAIRE

Diffusion-weighted imaging (DWI) may detect hyperintense lesions in patients with transient hypoglycaemia-induced hemiparesis or coma, which are completely reversible after glucose infusion.1–3 In vivo animal studies have documented the visualisation of such hypoglycaemia-induced changes of signal intensity and the reversal by glucose intake in detail.4 However, the time necessary for hyperintense lesions on DWI to disappear after glucose infusion in humans is still unclear. A 54 year old w...

Maruya, J.; Endoh, H.; Watanabe, H.; Motoyama, H.; Abe, H.

2007-01-01

293

Phenolic profiles of cultivated, in vitro cultured and commercial samples of Melissa officinalis L. infusions  

OpenAIRE

Melissa officinalis L. (lemon balm) is normally consumed as infusions and presents therapeutic properties such as sedative, carminative and antispasmodic, being also included in some pharmaceutical preparations. The phenolic profiles of different samples of lemon balm prepared as infusions were evaluated by HPLC-DAD-ESI/MS. The profiles were compared in order to understand the differences between cultivated, in-vitro cultured and commercial (bags and granulated) samples. All the samples showe...

Barros, Lillian; Duen?as, Montserrat; Dias, Maria Ine?s; Sousa, Maria Joa?o; Santos-buelga, Celestino; Ferreira, Isabel C. F. R.

2013-01-01

294

Recombinant human tripeptidyl peptidase-1 infusion to the monkey CNS: safety, pharmacokinetics, and distribution.  

Science.gov (United States)

CLN2 disease is caused by deficiency in tripeptidyl peptidase-1 (TPP1), leading to neurodegeneration and death. The safety, pharmacokinetics (PK), and CNS distribution of recombinant human TPP1 (rhTPP1) were characterized following a single intracerebroventricular (ICV) or intrathecal-lumbar (IT-L) infusion to cynomolgus monkeys. Animals received 0, 5, 14, or 20mg rhTPP1, ICV, or 14 mg IT-L, in artificial cerebrospinal fluid (aCSF) vehicle. Plasma and CSF were collected for PK analysis. Necropsies occurred at 3, 7, and 14 days post-infusion. CNS tissues were sampled for rhTPP1 distribution. TPP1 infusion was well tolerated and without effect on clinical observations or ECG. A mild increase in CSF white blood cells (WBCs) was detected transiently after ICV infusion. Isolated histological changes related to catheter placement and infusion were observed in ICV treated animals, including vehicle controls. The CSF and plasma exposure profiles were equivalent between animals that received an ICV or IT-L infusion. TPP1 levels peaked at the end of infusion, at which point the enzyme was present in plasma at 0.3% to 0.5% of CSF levels. TPP1 was detected in brain tissues with half-lives of 3-14 days. CNS distribution between ICV and IT-L administration was similar, although ICV resulted in distribution to deep brain structures including the thalamus, midbrain, and striatum. Direct CNS infusion of rhTPP1 was well tolerated with no drug related safety findings. The favorable nonclinical profile of ICV rhTPP1 supports the treatment of CLN2 by direct administration to the CNS. PMID:24642058

Vuillemenot, Brian R; Kennedy, Derek; Reed, Randall P; Boyd, Robert B; Butt, Mark T; Musson, Donald G; Keve, Steve; Cahayag, Rhea; Tsuruda, Laurie S; O'Neill, Charles A

2014-05-15

295

An Oxytocin Antagonist Infused Into the Central Nucleus of the Amygdala Increases Maternal Aggressive Behavior  

OpenAIRE

Decreased oxytocin levels in the amygdalas of rat dams following chronic gestational cocaine exposure have been correlated with heightened maternal aggressive behavior. In this experiment, drug-naive dams were implanted with bilateral cannulas into the central nucleus of the amygdala (CNA) or control area and infused with 1,000 or 500 ng of an oxytocin antagonist (OTA) or buffer, 4 hr before testing. Behavior was compared among dams infused with OTA into target areas just outside the CNA and ...

Lubin, Deborah A.; Elliott, Jay C.; Black, Mitchell C.; Johns, Josephine M.

2003-01-01

296

Duodenal levodopa infusion for advanced Parkinson's disease: 12-month treatment outcome  

OpenAIRE

We assessed prospectively clinical and quality of life changes in 9 patients with Parkinson's disease (PD; HY > or = 3) with severe motor fluctuations and dyskinesia who started continuous daily levodopa duodenal infusion through percutaneous endoscopic gastrostomy. Seven patients completed the follow-up period. Duration of 'off' periods and time with disabling dyskinesia shortened significantly in all patients (P < 0.01). Total daily dose of levodopa infused did not differ from baseline equi...

Lopiano, Leonardo; Zibetti, Maurizio

2007-01-01

297

Prolonged increase in digital blood flow following iloprost infusion in patients with systemic sclerosis.  

OpenAIRE

Thirteen patients with Raynaud's phenomenon secondary to systemic sclerosis received three 8-hour infusions of a synthetic prostacyclin analogue (Iloprost) on consecutive days and were followed-up over a period of 10 weeks during the winter of 1985/86. Six weeks after infusion, digital peripheral vascular resistance had fallen (P less than 0.05) and dicrotic notch proportion of pulse amplitude increased (P less than 0.05). Digital blood flow and pulse amplitude (measured by photoplethymograph...

Rademaker, M.; Thomas, R. H.; Provost, G.; Beacham, J. A.; Cooke, E. D.; Kirby, J. D.

1987-01-01

298

Effect of increasing intraperitoneal infusion rates on bupropion hydrochloride-induced seizures in mice  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background It is not known if there is a relationship between input rate and incidence of bupropion-induced seizures. This is important, since different controlled release formulations of bupropion release the active drug at different rates. Methods We investigated the effect of varying the intraperitoneal infusion rates of bupropion HCl 120 mg/kg, a known convulsive dose50 (CD50, on the incidence and severity of bupropion-induced convulsions in the Swiss albino mice. A total of 69 mice, approximately 7 weeks of age, and weighing 21.0 to 29.1 g were randomly assigned to bupropion HCl 120 mg/kg treatment by intraperitoneal (IP administration in 7 groups (9 to 10 animals per group. Bupropion HCl was infused through a surgically implanted IP dosing catheter with infusions in each group of 0 min, 15 min, 30 min, 60 min, 90 min, 120 min, and 240 min. The number, time of onset, duration and the intensity of the convulsions or absence of convulsions were recorded. Results The results showed that IP administration of bupropion HCl 120 mg/kg by bolus injection induced convulsions in 6 out of 10 mice (60% of convulsing mice in group 1. Logistic regression analysis revealed that infusion time was significant (p = 0.0004; odds ratio = 0.974 and increasing the IP infusion time of bupropion HCl 120 mg/kg was associated with a 91% reduced odds of convulsions at infusion times of 15 to 90 min compared to bolus injection. Further increase in infusion time resulted in further reduction in the odds of convulsions to 99.8% reduction at 240 min. Conclusion In conclusion, the demonstration of an inverse relationship between infusion time of a fixed and convulsive dose of bupropion and the risk of convulsions in a prospective study is novel.

Fleming Rosanna

2008-12-01

299

Evaluation of slow infusions of co-trimoxazole by using predictive pharmacokinetics.  

OpenAIRE

Digital computer simulations of plasma concentration-time profiles of single intravenous infusions of trimethoprim (160 mg)/sulfamethoxazole (800 mg) based on data from other workers showed that increasing the infusion period from the hitherto generally recommended 1 to 1.5 h to 6 h did not significantly affect the interval (approximately 10 h and 8.5 h, respectively) during which trimethoprim and sulfamethoxazole plasma concentrations were maintained above their minimum effective plasma conc...

Morgan, D. J.; Raymond, K.

1980-01-01

300

Glycine and urea kinetics in nonalcoholic steatohepatitis in human: effect of intralipid infusion  

OpenAIRE

The rates of oxidation of glycine and ureagenesis were quantified in the basal state and in response to an intravenous infusion of intralipid with heparin (IL) in healthy subjects (n = 8) and in subjects with nonalcoholic steatohepatitis (NASH) (n = 6). During fasting, no significant difference in weight-specific rate of appearance (Ra) of glycine, glycine oxidation, and urea synthesis was observed. Intralipid infusion resulted in a significant increase in plasma ?-hydroxybutyrate in both gr...

Dasarathy, Srinivasan; Kasumov, Takhar; Edmison, John M.; Gruca, Lourdes L.; Bennett, Carole; Duenas, Clarita; Marczewski, Susan; Mccullough, Arthur J.; Hanson, Richard W.; Kalhan, Satish C.

2009-01-01

301

Effects of amino acid infusion on renal hemodynamics. Role of endothelium-derived relaxing factor.  

Science.gov (United States)

Ingestion of protein or intravenous infusion of amino acids acutely elevates glomerular filtration rate (GFR) and renal plasma flow (RPF) by unknown mechanisms. Endothelium-derived relaxing factor (EDRF), now known to be nitric oxide derived from metabolism of L-arginine, participates in local regulation of vascular tone. To investigate the hypothesis that EDRF may participate in the renal vasodilatation and increased GFR after amino acid infusion, we characterized the effect of inhibition of EDRF synthesis with NG-monomethyl L-arginine (LNMMA) on basal renal hemodynamics and the response to infusion of a 10% mixed amino acid solution (1 ml/hr i.v.) in the rat. Renal arterial infusion of LNMMA (500 micrograms/kg/min) resulted in a significant increase in mean arterial pressure, decreases in GFR (20%) and RPF (44%), and a significant increase in filtration fraction. Pretreatment with the angiotensin II receptor antagonist Sar-Gly-angiotensin II did not prevent the increase in blood pressure but blunted the decreases in GFR (11%) and RPF (27%) after LNMMA infusion. Amino acid infusion in the untreated, fasted rat resulted in no change in blood pressure but significant increases in GFR and RPF; these effects were completely inhibited by intrarenal LNMMA but not an equihypertensive intravenous infusion of phenylephrine. In summary, EDRF participates in regulation of basal renal hemodynamics. Furthermore, amino acid-induced hyperfiltration and renal vasodilatation are completely prevented by inhibition of EDRF synthesis. We conclude that EDRF may participate in the renal hemodynamic response to amino acid infusion. PMID:2045148

Tolins, J P; Raij, L

1991-06-01

302

Metabolic and hemodynamic effects of saline infusion to maintain volemia on temporary abdominal aortic occlusion  

OpenAIRE

OBJECTIVE: To analyze hemodynamic and metabolic effects of saline solution infusion in the maintenance of blood volume in ischemia-reperfusion syndrome during temporary abdominal aortic occlusion in dogs. METHODS: We studied 20 dogs divided into 2 groups: the ischemia-reperfusion group (IRG, n=10) and the ischemia-reperfusion group with saline solution infusion aiming at maintaining mean pulmonary arterial wedge pressure between 10 and 20 mmHg (IRG-SS, n=10). All animals were anesthetized wit...

Fábio Ferreira Amorim; Bruno do Vale Pinheiro; Hélio Romaldini

2002-01-01

303

Infusion pumps for systemic and intra-arterial chemotherapy of colorectal liver metastases.  

OpenAIRE

Over a 12 month period, we prospectively evaluated the use of an ambulatory infusion pump for intra-arterial and intravenous chemotherapy in patients with colorectal liver metastases. In all, 274 separate infusions were given with minor complications occurring on six occasions. Administering treatment on an outpatient basis rather than as an inpatient has resulted in savings of over Pounds 17000 in the first year.

Howell, J. D.; Gallagher, H.; Kane, E.; Maguire, R.; Mcardle, C. S.

1997-01-01

304

Randomised controlled trial of low dose fentanyl infusion in preterm infants with hyaline membrane disease  

OpenAIRE

Aim—To evaluate the effects of low dose fentanyl infusion analgesia on behavioural and neuroendocrine stress response and short term outcome in premature infants ventilated for hyaline membrane disease.?METHODS—Twenty seven ventilated preterm infants were randomly assigned to receive a mean fentanyl infusion of 1.1 (0.08 SE) µg/kg/h for 75 (5) hours, and 28 untreated infants were considered a control group. A behavioural sedation score was used to assess the infants' ...

Lago, P.; Benini, F.; Agosto, C.; Zacchello, F.

1998-01-01

305

Voxelized Model of Interstitial Transport in the Rat Spinal Cord Following Direct Infusion Into White Matter  

OpenAIRE

Direct tissue infusion, e.g., convection-enhanced delivery (CED), is a promising local delivery technique for treating diseases of the central nervous system. Predictive models of spatial drug distribution during and following direct tissue infusion are necessary for treatment optimization and planning of surgery. In this study, a 3D interstitial transport modeling approach in which tissue properties and anatomical boundaries are assigned on a voxel-by-voxel basis using tissue alignment data ...

Kim, Jung Hwan; Astary, Garrett W.; Chen, Xiaoming; Mareci, Thomas H.; Sarntinoranont, Malisa

2009-01-01

306

INDEFINITE SURVIVAL OF RAT ISLET ALLOGRAFTS FOLLOWING INFUSION OF DONOR BONE MARROW WITHOUT CYTOABLATION  

OpenAIRE

We have tested the effect of donor bone marrow cell (DBMC) infusion on the survival of pancreatic islet allografts in the rat, without the use of cytoablative recipient conditioning. Lewis and diabetic Brown Norway rats were used as donors and recipients, respectively. Donor islets were placed beneath the left renal capsule. Infusion of DBMC and temporary immunosuppression followed by delayed islet transplantation resulted in indefinite survival of all islet grafts (MST >180 days). Control an...

Ricordi, Camillo; Murase, Norico; Rastellini, Cristiana; Behboo, Roubik; Demetris, Anthony J.; Starzl, Thomas E.

1996-01-01

307

Effects of various arterial infusion solutions on red blood cells in the newborn  

OpenAIRE

AIM—To examine in vitro the effects of brief contact with various infusion solutions on red blood cells from newborn infants, as occurs in the "waste" syringe during routine blood sampling from umbilical artery catheters. The mixture of blood and solution in the "waste" syringe is usually reinfused into the baby. Reinfused red blood cells may be damaged by the infusion solution. It is hypothesised that an isotonic amino acid solution would cause no red blood cell agglut...

Jackson, J.; Derleth, D.

2000-01-01

308

Systemic and regional hemodynamic effects of enalaprilat infusion in experimental normotensive sepsis  

OpenAIRE

Angiotensin-converting enzyme inhibitors have been shown to improve splanchnic perfusion in distinct shock states. We hypothesized that enalaprilat potentiates the benefits of early fluid resuscitation in severe experimental sepsis, particularly in the splanchnic region. Anesthetized and mechanically ventilated mongrel dogs received an intravenous infusion of live Escherichia coli over a period of 30 min. Thereafter, two interventions were performed: fluid infusion (normal saline, 32 mL/kg ov...

Rahal L.; Garrido A.G.; Cruz Jr. R.J.; Rocha e Silva M.; Poli-de-Figueiredo L.F.

2006-01-01

309

Selection of vasodilator therapy for severe Raynaud's phenomenon by sequential arterial infusion.  

OpenAIRE

Two young adults with impending gangrene due to persistent Raynaud's vasospasm were studied by sequential intra-arterial (IA) infusion of three vasodilatory drugs while arterial pressure and plethysmographic digital pulse volume were continuously monitored. The results of the IA infusion accurately predicted relief from vasospastic symptoms by oral drugs of the same class. This method may be useful in selecting the most effective vasodilator for patients with severe vasospasm.

Russell, I. J.; Walsh, R. A.

1985-01-01

310

The infusion of fauna of water cleaning installations working with mechanical method  

International Nuclear Information System (INIS)

According to our investigations 77 kinds of infusions are determined in the watercleaning installations, working with mechanical method. In the given article the description of watercleaning installations, spreading of infusions on taxons in water purifying basins, their changes according to the seasons, the number of dynamics on biotops, the comparison of siliofauna of cleaning installations on their role in the cleaning of water are analyzed

311

Decoction, infusion and hydroalcoholic extract of cultivated thyme : antioxidant and antibacterial activities, and phenolic characterisation  

OpenAIRE

Bioactivity of thyme has been described, but mostly related to its essential oils, while studies with aqueous extracts are scarce. Herein, the antioxidant and antibacterial properties of decoction, infusion and hydroalcoholic extract, as also their phenolic compounds, were evaluated and compared. Decoction showed the highest concentration of phenolic compounds (either phenolic acids or flavonoids), followed by infusion and hydroalcoholic extract. In general, the samples were effective against...

Martins, Nat Lia; Barros, Lillian; Santos-buelga, Celestino; Silva, S. Nia Carina; Henriques, Mariana; Ferreira, Isabel C. F. R.

2015-01-01

312

A direct growth effect of growth hormone in rat hindlimb shown by arterial infusion.  

Science.gov (United States)

We have developed a method for infusing substances into one hindlimb of the rat via the arterial supply. A catheter attached to an osmotic minipump is inserted into the right superior vesical artery and advanced to the junction of the right common iliac artery. This arrangement permits either constant or pulsatile infusion for 7 days. We employed this method to study the direct action of rat growth hormone (rGH) on the proximal tibial epiphysial plate in hypophysectomized rats. Infusion of neither the solvent nor ovine prolactin (2 micrograms X rat-1 X day -1) affected epiphysial plate width compared with control (uninfused) legs. The rGH infused at 0.4 and 2.0 micrograms X rat-1 X day-1 produced dose-related local growth effects that were of similar magnitude with either constant or pulsatile (eight 1-h pulses/day) infusion. However, the higher dose of rGH also resulted in a systemic effect (i.e., epiphysial plate growth in the uninfused limb), and the pulsatile mode produced a greater systemic effect than that produced by constant infusion. Our results indicate that GH can act directly on cartilage in vivo to maintain growth and that its effectiveness is not enhanced by pulsatile delivery. In contrast, the indirect (i.e., systemic) growth effects of the hormone may be enhanced by intermittent infusion. Our infusion system is well suited for studying the direct effect of substances on hindlimb tissues in conscious, unrestrained rats over extended periods. PMID:3953810

Schlechter, N L; Russell, S M; Greenberg, S; Spencer, E M; Nicoll, C S

1986-03-01

313

Enhanced Distal Nephron Sodium Reabsorption in Chronic Angiotensin II Infused Mice  

OpenAIRE

Chronic angiotensin II (Ang II) infusions enhance urinary excretion of angiotensinogen suggesting augmentation of distal nephron sodium reabsorption. To assess if chronic Ang II infusions (15 ng/min for 2 weeks) enhance distal nephron sodium reabsorption, we compared sodium excretion before and following blockade of the two main distal nephron sodium transporters by iv amiloride (5 mg/kg body weight) plus bendroflumethiazide (12 mg/kg body weight) in male C57/BL6 anesthetized control mice (n=...

Zhao, Di; Seth, Dale M.; Navar, L. Gabriel

2009-01-01

314

Effect of intravenous iron-dextran (Imferon) infusion on antigen induced monarticular arthritis in rabbits.  

OpenAIRE

The effect of intravenously infused iron-dextran (Imferon) on the progression of antigen induced monarticular arthritis in rabbits was studied. A rapid deposition of iron and apoferritin in the synovia of arthritis joints occurred after infusion of iron-dextran during either the acute or chronic phases of the disease. This coincided with the appearance of catalytic (bleomycin reactive) iron in the synovial fluid. There was no evidence, however, for an exacerbation of the antigen induced arthr...

Kind, C. N.; Blackham, A.; Morris, C. J.

1992-01-01

315

The pharmacokinetics of 5-fluorouracil administered by arterial infusion in advanced colorectal hepatic metastases.  

OpenAIRE

The pharmacokinetics of 5-fluorouracil (5FU) following its administration via the hepatic artery in conjunction with biodegradable albumin microspheres and angiotensin II have been studied. Peripheral venous concentrations of 5FU are lower and plasma clearance values higher following intrahepatic arterial administration compared with a similar dose administered by intravenous infusion over both 2 h and 24 h. For the 2 h drug infusions, plasma 5FU concentrations following co-treatment with ang...

Goldberg, J. A.; Kerr, D. J.; Watson, D. G.; Willmott, N.; Bates, C. D.; Mckillop, J. H.; Mcardle, C. S.

1990-01-01

316

Teaching new graduate nurses about infusion therapy in a nurse residency program.  

Science.gov (United States)

The purpose of this article is to describe how the concept of infusion nursing was incorporated into orientation for new graduate nurses at an academic medical center in the Midwest. Strategies were identified based on their unique learning needs and a desire to instill safe infusion practices early in their nursing careers. (A Supplemental Video Abstract for this article is available at http://links.lww.com/JIN/A64.). PMID:25545974

McPhee, Kim

2015-01-01

317

Brittle diabetes: long-term control with a portable, continuous, intravenous insulin infusion system.  

OpenAIRE

A young woman had severe brittle diabetes mellitus that was critically unmanageable with all conventional insulin treatment. Continuous subcutaneous and intramuscular infusions of insulin also failed to control her metabolic instability. Use of a continuous intravenous infusion, however, whereby a portable, variable-rate, battery-operated syringe pump delivered insulin through a subcutaneously tunnelled central venous catheter, resulted in good control. When she was receiving hourly intramusc...

Bayliss, J.

1981-01-01

318

Infusion of donor leukocytes to induce tolerance in organ allograft recipients  

OpenAIRE

To further enhance chimerism, 229 primary allograft recipients have received perioperative intravenous infusion of a single dose of 3 to 6 × 108 unmodified donor bone marrow (BM) cells/kg body weight. In addition, 42 patients have been accrued in a concurrent protocol involving multiple (up to three) sequential perioperative infusions of 2 × 108 BM cells/kg/day from day 0–2 posttransplantation (PTx). Organ recipients (n = 133) for whom BM was not available were monitored as controls. The ...

Salgar, S. K.; Shapiro, R.; Dodson, F.; Corry, R.; Mccurry, K.; Zeevi, A.; Pham, S.; Abu-elmagd, K.; Reyes, J.; Jordan, M.; Keenan, R.; Griffith, B.; Sesky, T.; Ostrowski, L.; Starzl, T. E.

1999-01-01

319

Saline Infusion Markedly Reduces Impedance and Improves Efficacy of Pulmonary Radiofrequency Ablation  

International Nuclear Information System (INIS)

Radiofrequency ablation (RFA) is a relatively new technique that has been investigated for the treatment of lung tumors. We evaluated for the first time the in vivo use of saline infusion during radiofrequency ablation of sheep lung. We performed RFA on 5 sheep using open and closed chest RFA and the RITA starburst XL and Xli probes using saline infusion with the Xli probe. The impedance and volume of ablation were compared. A total of 16 ablations were produced, 5 percutaneously and 11 open. The impedance during percutaneous and open RFA without saline infusion was 110 ± 16.2 and 183.3 ± 105.8 O, respectively. With the saline infusion the impedance was 71.3 ± 22O and 103.6 ± 37.5O. The effect of this was a significantly larger volume of ablation using the saline infusion during percutaneous RFA (90.6 ± 23 cm3 vs 10.47 ± 2.9 cm3, p = 0.01) and open RFA (107.8 ± 25.8 cm3 vs 24.9 ± 19.3 cm3, p = 0.0002). Saline infusion during RFA is associated with lower impedance, higher power delivery and larger lesion size

320

Should we use closed or open infusion containers for prevention of bloodstream infections?  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Hospitalized patients in critical care settings are at risk for bloodstream infections (BSI. Most BSIs originate from a central line (CL, and they increase length of stay, cost, and mortality. Open infusion containers may increase the risk of contamination and administration-related (CLAB because they allow the entry of air into the system, thereby also providing an opportunity for microbial entry. Closed infusion containers were designed to overcome this flaw. However, open infusion containers are still widely used throughout the world. The objective of the study was to determine the effect of switching from open (glass, burettes, and semi-rigid infusion containers to closed, fully collapsible, plastic infusion containers (Viaflex® on the rate and time to onset of central line-associated bloodstream infections CLABs. Methods An open label, prospective cohort, active healthcare-associated infection surveillance, sequential study was conducted in four ICUs in Mexico. Centers for Disease Control National Nosocomial Infections Surveillance Systems definitions were used to define device-associated infections. Results A total of 1,096 adult patients who had a central line in place for >24 hours were enrolled. The CLAB rate was significantly higher during the open versus the closed container period (16.1 versus 3.2 CLAB/1000 central line days; RR = 0.20, 95% CI = 0.11-0.36, P Conclusions Closed infusion containers significantly reduced CLAB rate, the probability of acquiring CLAB, and mortality.

Martinez-Soto Jose

2010-02-01

321

Experimental intraperitoneal infusion of OK-432 in rats: Evaluation of peritoneal complications and pathology  

Energy Technology Data Exchange (ETDEWEB)

Purpose: OK-432 is known to be a potent sclerosant of cystic lesions. The purpose of this study was to evaluate both its safety and pathologic effects after the infusion of OK-432 into the peritoneal cavity of rats. Materials and methods: Twenty male rats were used in this study. Twelve rats were infused intraperitoneally with 0.2 Klinishe Einheit of OK-432 melted in 2 mL of normal saline (group 1: the treated group); four rats each were infused intraperitoneally with 0.5 mL of 99% ethanol (group 2) and normal saline (group 3), and served as the control groups. An abdominal ultrasonographic examination was performed both before and after the infusions in all rats. Three rats in group 1 and one rat in each of groups 2 and 3 were sacrificed each week following the infusion. Gross and microscopic evaluations of the peritoneum and abdominal cavity were performed on each rat. Results: In group 1, the abdomen was clear on gross inspection and the peritoneum was unremarkable on microscopic examination. In group 2, mild-to-moderate peritoneal adhesions were revealed grossly, and inflammation and fibrosis of the peritoneum were demonstrated microscopically. In group 3, no specific abnormalities were noted on gross or microscopic examinations. Conclusion: Leakage or abnormal infusion of OK-432 solution into the peritoneal cavity during sclerotherapy of intra-abdominal or retroperitoneal cystic lesions does not result in any significant complications.

Kim, Dong Wook [Department of Radiology, Busan Paik Hospital, Inje University College of Medicine, Busan (Korea, Republic of); Kim, Hak Jin, E-mail: hakjink@pusan.ac.k [Department of Radiology, Pusan National University Hospital, Pusan National University College of Medicine, Medical Research Institute, Busan (Korea, Republic of); Lee, Jun Woo [Department of Radiology, Pusan National University Hospital, Pusan National University College of Medicine, Medical Research Institute, Busan (Korea, Republic of)

2010-06-15

322

Investigation of the release behavior of DEHP from infusion sets by paclitaxel-loaded polymeric micelles.  

Science.gov (United States)

The current clinical formulation of paclitaxel (Taxol) contains 1:1 blend of Cremophor EL (polyethoxylated castor oil) and dehydrated ethanol. Cremophor EL and dehydrated ethanol are well known to leach di-(2-ethylhexyl) phthalate (DEHP) from polyvinyl chloride (PVC) infusion bags and PVC administration sets. DEHP is a possible hepatotoxin, carcinogen, teratogen and mutagen. Long-term exposure to DEHP may cause health risks. As an alternative formulation for paclitaxel, paclitaxel-loaded polymeric micelles (PLPM), made of monomethoxy poly(ethylene glycol)-block-poly(d,l-lactide) (mPEG-PDLLA) diblock copolymer, has demonstrated clear advantages over Taxol in pharmacokinetics and therapeutic index. Paclitaxel in either PLPM or Taxol formulations, diluted in 0.9% sodium chloride injection, was stable in the PVC infusion bags. The PLPM formulation significantly reduced the amount of DEHP extracted from PVC infusion bags and PVC administration sets. For PLPM diluted in 0.9% sodium chloride injection, the total amount of DEHP delivered over the simulated infusion period was 0.7 mg for 3h and 2.0 mg for 24 h, which was less than 2.9% of the DEHP extracted by Taxol. These results confirmed that there is negligible risk of DEHP exposure from diluted PLPM i.v. infusion using PVC infusion bags and PVC administration sets. PMID:15778068

Kim, Sung Chul; Yoon, Hye Jeong; Lee, Jang Won; Yu, Jaewon; Park, Eun-Seok; Chi, Sang-Cheol

2005-04-11

323

Eggplant (Solanum melongena infusion has a modest and transitory effect on hypercholesterolemic subjects  

Directory of Open Access Journals (Sweden)

Full Text Available Eggplant (Solanum melongena is consumed extensively in Brazil. It has been believed that infusion of a powdered preparation of the fruit may reduce serum cholesterol. However, there are few documented reports on its effects on cholesterol metabolism and its possible hypocholesterolemic effect has not been proved by well-controlled studies. The aim of the present study was to observe the effects of S. melongena on the serum cholesterol and triglycerides of 38 hypercholesterolemic human volunteers ingesting S. melongena infusion for five weeks. Thirty-eight hypercholesterolemic subjects receiving either S. melongena infusion (N = 19 or placebo (N = 19 participated in two clinical experiments in which the effect of S. melongena infusion was studied with (N = 16 or without (N = 38 dietary orientation. Total cholesterol and its fractions, triglycerides, and apolipoproteins A and B were measured in blood at the beginning of the experiment and three and five weeks thereafter. No differences were observed compared to control. Intraindividual analysis showed that S. melongena infusion significantly reduced the blood levels of total and LDL cholesterol and of apolipoprotein B. After dietary orientation, no intra- or intergroup differences were seen for any of the parameters analyzed. The results suggest that S. melongena infusion had a modest and transitory effect, which was not different from that obtained with standard orientation for dyslipidemia patients (diet and physical activities.

Guimarães P.R.

2000-01-01

324

Determination of trace elements in herbal tea products and their infusions consumed in Thailand.  

Science.gov (United States)

Nineteen elements, Mg, Al, Ca, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Se, Sr, Sb, Ba, As, Cd, Hg, and Pb, were determined in three types of popular herbal tea products, Gynostemma pentaphyllum, Camellia sinensis, and Morus alba. These herbal tea products, both imported and locally made products, are widely consumed in Thailand and worldwide. Microwave-assisted acid digestion was used for all of the samples, and the element contents were determined by ICP-MS. The concentrations of all elements varied among these herbal teas. Ca and Mg were the most abundant elements in all herbal samples (1384-34070 and 783-7739 mg/kg, respectively). Most elements in these herbal tea powders were also released into the infusions at different percentages depending on types of herbs. G. pentaphyllum infusion contained essential elements (Mg, Ca, V, and Fe) at higher levels than C. sinensis and M.alba infusions. Al and Ni were present at high levels in C. sinensis infusion, and Cd level was high in M. alba infusion. The daily intake of all elements from these herbal tea infusions (three cups/day) is still within the average daily intake. Therefore, it may not produce any health risks for human consumption, if other sources of toxic metal contaminated food are not taken at the same time. PMID:16939361

Nookabkaew, Sumontha; Rangkadilok, Nuchanart; Satayavivad, Jutamaad

2006-09-01

325

Prolonging ?-lactam infusion: a review of the rationale and evidence, and guidance for implementation.  

Science.gov (United States)

Given the sparse antibiotic pipeline and the increasing prevalence of resistant organisms, efforts should be made to optimise the pharmacodynamic exposure of currently available agents. Prolonging the infusion duration is a strategy used to increase the percentage of the dosing interval that free drug concentrations remain above the minimum inhibitory concentration (fT>MIC), the pharmacodynamic efficacy driver for time-dependent antibiotics such as ?-lactams. ?-Lactams, the most commonly prescribed class of antibiotics owing to their efficacy and safety profile, have been the mainstay of therapy since the discovery of penicillin over 60 years ago. Mounting evidence, including the use of population pharmacokinetic modelling and Monte Carlo simulation, suggests that prolonging the infusion time of ?-lactam antibiotics may have advantages over standard infusion techniques, including an enhanced probability of achieving requisite fT>MIC exposures, lower mortality and potentially reductions in infection/antibiotic-related costs. As a result of these favourable attributes, clinical practice guidelines support the use of prolonged-infusion ?-lactams in the treatment of many severe infections. This article discusses the rationale and evidence for prolonging the infusion of ?-lactam antibiotics and provides guidance for the implementation of a prolonged-infusion programme. PMID:24359838

MacVane, Shawn H; Kuti, Joseph L; Nicolau, David P

2014-02-01

326

Effects of leucine, isoleucine, or threonine infusion on leucine metabolism in humans  

International Nuclear Information System (INIS)

Leucine and/or its ?-keto acid, ?-ketoisocaproate (KIC), have been reported to spare protein in humans. To determine whether specific amino acid infusions affect whole-body protein metabolism as estimated by changes in leucine flux and oxidation, five groups of normal subjects were infused with saline, leucine, isoleucine, or threonine. Independent estimates of leucine metabolism were obtained using simultaneous infusions of [3H]-leucine and ?-[14C]ketoisocaproate. Nearly identical results were obtained using either tracer compared with the saline controls. Compared with the saline controls, leucine infusion (1) had no effect on estimated rates of appearance of endogenous leucine, (2) stimulated leucine oxidation, (3) decreased plasma concentrations of other amino acids, and (4) stimulated nonoxidized leucine disappearance in a dose-dependent fashion. In contrast, isoleucine and threonine infusions had no effect on leucine metabolism. Assuming the validity of the isotope model employed, these data suggest that the purported anabolic effect of leucine infusion on whole-body protein metabolism is mediated via stimulation of protein synthesis rather than decreased proteolysis

327

Mechanisms of cell death induced by infusion sets leachables in in vitro experimental settings.  

Science.gov (United States)

Leachable materials that are released from infusion sets during their use can induce local and systemic toxic effects. We studied the mechanisms and kinetics of cell death induced by infusion sets leachates in vitro using L-929 and bEnd. 3 cells. Changes in cell morphology and metabolic activity were determined using light microscopy and the MTT test, respectively. Detailed analysis of the mechanisms of cell death was performed using membrane integrity and caspases 3 and 7 activity tests, annexin V-FITC/7-AAD analysis by FACS, and DAPI nuclear staining followed by confocal microscopy. Infusion sets released toxic leachables and induced toxic effects. Latex flashball was the most toxic part of the studied infusion sets, and it potently induced cell oncosis via increased permeability of the cell membrane. Latex-induced decrease in cells metabolic activity and cell death were not accompanied by activation of caspases 3 and 7, changes in nuclear morphology, or substantial annexin V-FITC cell staining. Leachables from the tube part of the infusion sets were less toxic, and induced some biochemical changes without altering the cells morphology. Further studies are needed to reveal the in vivo toxicity of infusion sets and its correlation with the results of in vitro toxicity studies. PMID:25510603

Kozlovskaya, Luba; Stepensky, David

2015-01-30

328

The availability of DSA used continuous intraarterial infusion tubes founded various malignancy  

International Nuclear Information System (INIS)

DSA was employed using continuous intraarterial infusion tubes for various malignancies (73 cases) which were examined a total of 135 times. In head and neck malignancy (50 cases), the general position of the infusion tube had been determined beforehand by dye infusion, but DSA from the tube showed that the tubes in 24 cases (48 %) were located in the wrong position, especially in tongue cancer (21 cases) where many tubes were discovered to be in an erroreous position (71 %) such as the common carotid artery. We were unable to determine the effect of chemotherapy and radiation using DSA only. In 9 cases of breast cancer for which fixation of the tube was not attempted under X-ray fluoroscopy, 7 (78 %) showed an unusual tube position such as the intraaortic arch. In 5 cases of abdominal malignancy, only the tube position for sigmoid colon cancer was unusual. We were able to observe the effect of chemotherapy by DSA in 2 cases. For DSA in one out of 3 hepatomas using a Port-A-Cath, we observed that infusion of anticancer drug with degradable starch microspheres caused a reduction in tumor size. However, in the two remaining cases, we were unable to observe any effect of infusion of these drugs by DSA for various mechanical reasons. DSA from an infusion tube revealed not only the location of the tube accurately and promptly, but also the effect of chemotherapy. (author)

329

Availability of DSA used continuous intraarterial infusion tubes founded various malignancy  

Energy Technology Data Exchange (ETDEWEB)

DSA was employed using continuous intraarterial infusion tubes for various malignancies (73 cases) which were examined a total of 135 times. In head and neck malignancy (50 cases), the general position of the infusion tube had been determined beforehand by dye infusion, but DSA from the tube showed that the tubes in 24 cases (48 %) were located in the wrong position, especially in tongue cancer (21 cases) where many tubes were discovered to be in an erroreous position (71 %) such as the common carotid artery. We were unable to determine the effect of chemotherapy and radiation using DSA only. In 9 cases of breast cancer for which fixation of the tube was not attempted under X-ray fluoroscopy, 7 (78 %) showed an unusual tube position such as the intraaortic arch. In 5 cases of abdominal malignancy, only the tube position for sigmoid colon cancer was unusual. We were able to observe the effect of chemotherapy by DSA in 2 cases. For DSA in one out of 3 hepatomas using a Port-A-Cath, we observed that infusion of anticancer drug with degradable starch microspheres caused a reduction in tumor size. However, in the two remaining cases, we were unable to observe any effect of infusion of these drugs by DSA for various mechanical reasons. DSA from an infusion tube revealed not only the location of the tube accurately and promptly, but also the effect of chemotherapy.

Minakuchi, Kazuo; Kobayashi, Nobuyuki; Yamada, Tetsuya

1987-10-01

330

[The availability of digital subtraction angiography using continuous intra-arterial infusion tubes founded various malignancy].  

Science.gov (United States)

DSA was employed using continuous intraarterial infusion tubes for various malignancies (73 cases) which were examined a total of 135 times. In head and neck malignancy (50 cases), the general position of the infusion tube had been determined beforehand by dye infusion, but DSA from the tube showed that the tubes in 24 cases (48%) were located in the wrong position, especially in tongue cancer (21 cases) where many tubes were discovered to be in an erroneous position (71%) such as the common carotid artery. We were unable to determine the effect of chemotherapy and radiation using DSA only. In 9 cases of breast cancer for which fixation of the tube was not attempted under X-ray fluoroscopy, 7 (78%) showed an unusual tube position such as the intraaortic arch. In 5 cases of abdominal malignancy, only the tube position for sigmoid colon cancer was unusual. We were able to observe the effect of chemotherapy by DSA in 2 cases. For DSA in one out of 3 hepatomas using a Port-A-Cath, we observed that infusion of anticancer drug with degradable starch microspheres caused a reduction in tumor size. However, in the two remaining cases, we were unable to observe any effect of infusion of these drugs by DSA for various mechanical reasons. DSA from an infusion tube revealed not only the location of the tube accurately and promptly, but also the effect of chemotherapy. PMID:3310906

Minakuchi, K; Kobayashi, N; Yamada, T; Manabe, T; Kaminou, T; Tubakimoto, M; Takashima, S; Nakatsuka, H; Nakamura, K; Oda, J

1987-10-01

331

Effect of abomasal ferrous lactate infusion on phosphorus absorption in lactating dairy cows.  

Science.gov (United States)

The objective of this study was to evaluate the effect of ferrous lactate infusion on postruminal P absorption in lactating dairy cows. Four ruminally cannulated lactating cows were used in a 4×4 Latin square design with 14 d per period. Cows were fed a basal diet containing 0.39% P, providing 100% of the calculated P requirement. On d 8 to 14 of each period, each cow was infused with 0, 200, 500, or 1,250mg of Fe/d in the form of ferrous lactate solution (ferrous lactate in 1L of double-distilled water) into the abomasum. Infusate was formulated to approximate 0, 2, 5, or 12.5mg of Fe/L in drinking water with 100L of water intake/d. Total fecal collection was conducted in the last 4 d of each period to measure nutrient digestion and excretion. Dry matter intake, milk yield, and milk composition were not affected by treatment. Digestibility of DM, NDF, and nitrogen decreased linearly with increasing ferrous lactate infusion. Infusion of ferrous lactate did not affect intake and digestibility of total P, inorganic P, or phytate P. In lactating cows, P absorption was not negatively influenced by abomasally infused ferrous lactate up to 1,250mg of Fe/d. PMID:23660146

Feng, X; Knowlton, K F; Dietrich, A D; Duncan, S

2013-07-01

332

Body Temperatures During Exercise in Deconditioned Dogs: Effect of NACL and Glucose Infusion  

Science.gov (United States)

Infusion of glucose (Glu) into normal exercising dogs attenuates the rise in rectal temperature (Delta-Tre) when compared with delta-Tre during FFA infusion or no infusion. Rates of rise and delta-=Tre levels are higher during exercise after confinement. Therefore, the purpose of this study was to determine if Glu infusion would attenuate the exercise-induced excess hyperthermia after deconditioning. Rectal and quadricep femoris muscle temperatures (Tmu) were measured in 7 male, mongrel dogs dogs (19.6 +/- SD 3.0 kg) during 90 minutes of treadmill exercise (3.1 +/-SD 0.2 W/kg) with infusion (30ml/min/kg) of 40% Glu or 0.9% NaCL before BC) and after confinement (AC) in cages (40 x 110 x 80 cm) for 8 wk. Mean (+/-SE body wt. were 19.6 +/- 1.1 kg BC and 19.5 +/- 1.1kg AC, exercise VO2 were not different (40.0 - 42.0 mi/min/kg-1). With NaCl AC, NaCl BC, GluAC, and GluBC: Delta-Tre were, 1.8, 1.4, 1.3 and 0.9C respectively; and Delta-Tmu were 2.3, 1.9, 1.6, and 1.4C. respectively (Ptemperature with Glu infusion must affect avenues of heat dissipation.

Greenleaf, J. E.; Kruk, B.; Nazar, K.; Kaciuba-Usciko, H.

2000-01-01

333

Flow manipulation and control methodologies for vacuum infusion processes  

Science.gov (United States)

Vacuum Infusion Processes (VIPs) are very attractive composite manufacturing processes since large structures such as fuselages and wind blades can be fabricated in a cost effective manner. In VIPs, the fabric layers are placed on a one sided mold which is closed by enveloping the entire mold with a thin plastic film and evacuating the air out. The vacuum compresses the fabric and when a resin inlet is opened, resin flows into the mold. The resin is allowed to cure before demolding the structure. However, VIPs causes non-repeatable and problematic resin filling patterns due to the heterogeneous nature of the material, nesting between various layers, and the hand labor utilized for laying up the fabric. The design of the manufacturing process routinely involves a trial and error model which make manufacturing costs and development time difficult to estimate. The clear solution to improving the reliability and robustness of VIPs is to implement a system capable of on-line flow control. While on-line flow control has been studied and developed for other composite manufacturing processes, the VIPs have been largely ignored as there are few process parameters that lend themselves to effective flow control. In this work, two new processes were discovered with the goal of on-line control of VIPs in mind. These two processes referred to as Flow Flooding Chamber (FFC) and Vacuum Induced Preform Relaxation (VIPR) will be discussed. They both employ an external vacuum chamber to influence the permeability of the fabric temporarily which allows one to redirect the resin flow to resin starved regions of the mold. The VIPR process in addition uses a low and regulated vacuum pressure in the external chamber to increase the permeability of the fabric in a controllable manner. The objective is to understand how the VIPR process affects the resin flow in order to implement it into a complete flow control and automated environment which will reduce or eliminate the variability experienced. First, the effect on permeability is characterized, so the process can be simulated and the flow front patterns can be predicted. It was found that using the VIPR process in combination with tool side injection gates is a very effective method to control resin flow. Based on this understanding several control algorithms were developed to use the process in an automated manufacturing environment which were tested and validated in a virtual environment. To implement and demonstrate the approach, an experimental workstation was built and various infusion examples were performed in the automated environment to validate the capability of the VIPR process with the control methodologies. The VIPR process with control consistently performed better than the process without control. This contribution should prove useful in making VIPs more reliable in the production of large scale composite structures.

Alms, Justin B.

334

Mechanical behaviour of composite materials made by resin film infusion  

Directory of Open Access Journals (Sweden)

Full Text Available Innovative composite materials are frequently used in designing aerospace, naval and automotive components. In the typical structure of composites, multiple layers are stacked together with a particular sequence in order to give specific mechanical properties. Layers are organized with different angles, different sequences and different technological process to obtain a new and innovative material. From the standpoint of engineering designer it is useful to consider the single layer of composite as macroscopically homogeneous material. However, composites are non homogeneous bodies. Moreover, layers are not often perfectly bonded together and delamination often occurs. Other violations of lamination theory hypotheses, such as plane stress and thin material, are not unusual and in many cases the transverse shear flexibility and the thickness-normal stiffness should be considered. Therefore the real behaviour of composite materials is quite different from the predictions coming from the traditional lamination theory. Due to the increasing structural performance required to innovative composites, the knowledge of the mechanical properties for different loading cases is a fundamental source of concern. Experimental characterization of materials and structures in different environmental conditions is extremely important to understand the mechanical behaviour of these new materials. The purpose of the present work is to characterize a composite material developed for aerospace applications and produced by means of the resin film infusion process (RFI. Different tests have been carried out: tensile, open-hole and filled-hole tensile, compressive, openhole and filled-hole compressive. The experimental campaign has the aim to define mechanical characteristics of this RFI composite material in different conditions: environmental temperature, Hot/Wet and Cold.

Casavola C.

2010-06-01

335

Saline infusion sonohysterography versus hysteroscopy for uterine cavity evaluation  

Directory of Open Access Journals (Sweden)

Full Text Available Background and Objectives: The most frequent procedures performed on women with abnormal uterine bleeding are 2D and 3D ultrasound. The most common accepted approach for the management of abnormal uterine bleeding is 2D TV scan followed by therapeutic hysteroscopy. The purpose of this prospective study was to assess whether 3D saline infusion sonohysterography (3D SIS could replace diagnostic hysteroscopy (DH for the diagnosis of endometrial pathology, in patients with abnormal uterine bleeding. Design and Setting: A prospective study in the ultrasound department of the Women?s Specialized Hospital, King Fahad Medical City, Riyadh, Saudi Arabia from January 2008 to February 2010. Patients and Methods: 0One hundred and one patients with abnormal uterine bleeding, suspected to have endometrial abnormality by 2D and 3D transvaginal scan, were prospectively studied. Of these, 55 patients had undergone both 3D SIS and DH, followed by verification of results with histopathology. Results: Upon comparison of 3D SIS and DH individually with histopathology, specificity and sensitivity for 3D SIS were 67% and 100%, respectively, and for hysteroscopy 67% and 98%, respectively. In addition, the positive predictive value and negative predictive value were 98% and 100%, respectively, for 3D SIS, while for DH they were 98% and 67%, respectively. Conclusion: 3D SIS is a safe alternative to hysteroscopy. However, larger randomized controlled trials should be conducted to ascertain the validity and reliability of this advantageous, less-invasive procedure, for women with abnormal uterine bleeding, who require evaluation of the endometrial cavity.

Khan Faryal

2011-01-01

336

A novel brain heart infusion broth supports the study of common Francisella tularensis serotypes.  

Science.gov (United States)

Francisella tularensis Schu S4, LVS and U112 have become model organisms for the study of Francisella pathogenesis, and represent a cross section of the different F. tularensis subspecies. Both Schu S4 and LVS are fastidious organisms, requiring medium fortified with supplements and nutrients for enhanced growth. Chamberlains defined medium, Tryptone Soy Broth supplemented with cysteine (TSBc), and cation-adjusted Mueller-Hinton broth (CAMHB) supplemented with 2% IsoVitaleX are typically used in the cultivation of these bacteria. In this report, we describe a simple brain heart infusion broth formulation that can be used to obtain superior growth characteristics in all of these model organisms, and can support bacterial growth from low inoculum. Surprisingly, CAMHB, which is favored in the literature for culturing Schu S4 and LVS, induced the worst growth characteristics of the four formulations studied. To expand on these observations, an additional seven strains of F. tularensis, representing types A.I, A.II, and B were selected from the Department of Defense United Culture Collection (UCC) and a comparative analysis of their growth characteristics performed in the four broth formulations. Results demonstrate differences in the growth characteristics of Francisella species that are significantly influenced by both strain type and the choice of growth medium. Though four of the five additional Type A strains displayed superior growth characteristics in Chamberlain's defined medium, growth characteristics of all three model organisms, as well the Type B strains, were enhanced by the new BHI-based broth formulation. We conclude that this medium represents the optimal choice for cultivation of the three model organisms used for Francisella research. PMID:20005265

Mc Gann, Patrick; Rozak, David A; Nikolich, Mikeljon P; Bowden, Robert A; Lindler, Luther E; Wolcott, Mark J; Lathigra, Raju

2010-02-01

337

Enhanced distal nephron sodium reabsorption in chronic angiotensin II-infused mice.  

Science.gov (United States)

Chronic angiotensin II (Ang II) infusions enhance urinary excretion of angiotensinogen, suggesting augmentation of distal nephron sodium reabsorption. To assess whether chronic Ang II infusions (15 ng/min for 2 weeks) enhance distal nephron sodium reabsorption, we compared sodium excretion before and after blockade of the 2 main distal nephron sodium transporters by IV amiloride (5 mg/kg of body weight) plus bendroflumethiazide (12 mg/kg of body weight) in male C57/BL6 anesthetized control mice (n=10) and in chronic Ang II-infused mice (n=8). Chronic Ang II infusions increased systolic blood pressure to 141+/-6 mm Hg compared with 106+/-4 mm Hg in control mice. After anesthesia, mean arterial pressure averaged 97+/-4 mm Hg in chronic Ang II-infused mice compared with 94+/-3 mm Hg in control mice, allowing comparison of renal function at similar arterial pressures. Ang II-infused mice had lower urinary sodium excretion (0.16+/-0.04 versus 0.30+/-0.05 microEq/min; P<0.05), higher distal sodium reabsorption (1.74+/-0.18 versus 1.12+/-0.18 microEq/min; P<0.05), and higher fractional reabsorption of distal sodium delivery (91.1+/-1.8% versus 77.9+/-4.3%; P<0.05) than control mice. Urinary Ang II concentrations, measured during distal blockade, were greater in Ang II-infused mice (1235.0+/-277.2 versus 468.9+/-146.9 fmol/mL; P<0.05). In chronic Ang II-infused mice treated with spironolactone (n=5), fractional reabsorption of distal sodium delivery was similarly augmented as in chronic Ang II-infused mice (94.6+/-1.7%; P<0.01). These data provide in vivo evidence that there is enhanced distal sodium reabsorption dependent on sodium channel and Na(+)-Cl(-) cotransporter activity and increased urinary Ang II concentrations in mice infused chronically with Ang II. PMID:19487583

Zhao, Di; Seth, Dale M; Navar, L Gabriel

2009-07-01

338

Effect of glucose supply on fasting nitrogen excretion and effect of level and type of volatile fatty acid infusion on response to protein infusion in cattle.  

Science.gov (United States)

Two experiments were carried out on cattle nourished entirely by intragastric infusion, to determine the extent to which glucose or a glucose precursor determines the response to protein infusion in energy-undernourished animals. In order to determine the requirement for glucose in 1-year-old fasting cattle, glucose was infused at increments to supply 0, 1.5, 2.5, 3.5, 4.5, 5.5 and 6.5 g/kg metabolic body weight (W0.75) and the effects on plasma beta-hydroxybutyrate and N excretion were measured. At 5.5 g glucose/kg W0.75 plasma beta-hydroxybutyrate was reduced to a basal level of 1.65 mmol/l and fasting N excretion reduced from 529 to 280 mg N/kg W0.75. No further reduction was observed with the higher level of 6.5 g glucose/kg W0.75. In the second trial, three steers were used in a 3 x 3 Latin square design and infused with a volatile fatty acid mixture of 65, 27 and 8 mol acetic, propionic and butyric acids respectively/100 mol, either at an estimated maintenance energy level of 450 kJ/kg W0.75 and supplying a calculated glucose equivalent level of 13.0 g/kg W0.75 (M1A), or at 1.5 x maintenance supplying a glucose equivalent of 20 g/kg W0.75 (M1.5A). Another mixture infused at the maintenance energy level contained 49, 43 and 8 mol acetic, propionic and butyric acids respectively/100 mol but with a glucose equivalent of 20 g/kg W0.75 (M1P). Casein was infused at each of these energy treatments to supply 0, 200, 400, 800, 1600 and 2500 mg N/kg W0.75 daily, and N balance and blood metabolites were measured. N retention increased linearly (r 0.98) with casein infusion. The coefficients for N retention were 0.55, 0.57 and 0.64 for M1A, M1.5A and M1P respectively. The mean efficiency of N utilization was 0.58. The results suggest that provided the glucose need is met there is no relationship between energy supply and efficiency and level of protein retention. However, the results also indicate that glucose requirement in cattle may be higher than that previously observed in sheep. PMID:10615211

Orskov, E R; Meehan, D E; MacLeod, N A; Kyle, D J

1999-05-01

339

Effect of intra-arterial infusion with triolein emulsion on rabbit liver  

Science.gov (United States)

AIM: To determine whether intra-arterial infusion of triolein emulsion has biochemical and histopathologic effect on rabbit liver. METHODS: An emulsion of 0.2 mL triolein in 20 mL of saline was infused into either the hepatic arteries of nine rabbits (group 1) or the superior mesenteric arteries of 12 rabbits (group 2). Five rabbits infused with 20 mL of normal saline were used as a control group (group 3). The serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were measured to evaluate liver function in each group just before the infusion, at 2 h, day 1, day 4, and day 7 following infusion. Each rabbit in all of the groups was infused with Evans blue on day 7 to evaluate changes in vascular permeability, and obtain the stained area of the hepatic surface. If the stained area was not available, the anteroinferior portion of the right hepatic lobe was selected. The obtained tissues were examined by light, electron and confocal microscopy. The changes in AST and ALT levels at each time point were calculated and statistically analyzed using a mixed linear model. A P value 0.05). Only three rabbits in each group showed hepatic surface staining with the Evans blue dye. Light and electron microscopic findings showed no specific changes in the selected hepatic tissues. Confocal microscopic examination with transferase-mediated dUTP nick-end labeling stain revealed lack of hepatocyte apoptosis in any of the groups. There were no differences in the results between group 1 and group 2. CONCLUSION: Infusion of triolein emulsion into rabbit livers revealed a minimal transient decrease of liver function, and no specific histopathologic changes. PMID:25339830

Kim, Yong-Woo; Park, Young Mi; Yoon, Sik; Kim, Hak Jin; Park, Do Yoon; Cho, Byung Mann; Choi, Seon Hee

2014-01-01

340

Five-year clinical effects of donor bone marrow cells infusions in kidney allograft recipients  

Science.gov (United States)

Augmentation of microchimerism in solid organ transplant recipients by donor bone marrow cells (DBMC) infusion may promote immune hyporesponsiveness and consequently improve long-term allograft survival. Between March 2005 and July 2007, outcomes for 20 living unrelated donor (LURD) primary kidney recipients with concurrent DBMC infusion (an average of 2.19 ± 1.13 x 109 donor cells consisting of 2.66 ± 1.70 x 107 CD34+ cells) were prospectively compared with 20 non-infused control allograft recipients given similar conventional immunosuppressive regimens. With five years of clinical follow up, a total of 11 cases experienced rejection episodes (3 DBMI patients vs. 8 controls, p = 0.15). One DBMC-infused patient experienced chronic rejection vs. two episodes (1 biopsy-confirmed) in the control patients. Actuarial and death-censored 5-y graft survival was significantly higher in infused patients compared with controls (p = 0.01 and p = 0.03, respectively). Long-term graft survival was significantly associated with pre-transplant anti-HLA antibodies (p = 0.01), slightly with peripheral microchimerism (p = 0.09) and CD4+CD25+FoxP3+ T cells (p = 0.09). Immunosuppressant dosing was lower in infused patients than controls, particularly for mycophenolate mofetil (p = 0.001). The current findings as well as our previous reports on these patients indicates clinical improvement in long-term graft survival of renal transplant patients resulting from low-dose DBMC infusion given without induction therapy. PMID:23639966

Solgi, Ghasem; Gadi, Vijayakrishna; Paul, Biswajit; Mytilineos, Joannis; Pourmand, Gholamreza; Mehrsai, Abdolrasoul; Ranjbar, Moslem; Mohammadnia, Mousa; Nikbin, Behrouz; Amirzargar, Ali Akbar

2013-01-01

341

Two-operator glucose infusion test (GIT2) for vascular access recirculation measurement during hemodialysis.  

Science.gov (United States)

Vascular access recirculation rate (AR) monitoring is fundamental to guarantee treatment adequacy and to detect access failure early. We have evaluated the GIT2 test to measure AR unaffected by cardio-pulmonary recirculation (CPR), based on a short glucose infusion in place of the bolus and on a two-operator sampling, differently from the classical glucose infusion test (GIT). The GIT2 test is based on four steps: 1) basal (B) glucose arterial sample; 2) 10% glucose infusion for 1 min, by infusion pump at 600 ml/hr; (or 20% at 300 ml/hr); 3) simultaneous sampling at arterial (A) and venous (V) ports, after 35-40 sec from starting the infusion, taking care to avoid blood pump stop during the test; 4) AR=100*((A-B)/(V-B)). In vitro tests by dialysis on a 40 L tank containing a urea solution, with AR volumetrically simulated at 0, 5, 10, 20%, and in vivo comparison of GIT, GIT2 with stop-flow (SF) urea method. Our results have shown in vitro an almost perfect correspondence of SF urea method and a better reliability of GIT2 than GIT. The methylene-blue test has shown that a single color bolus in V reaches the A port after variable time, depending on blood flow and AR, while the continuous infusion determines a steady gradient after about 30". In vivo tests (n=24) show good correspondence between GIT2 (4.37 +/- 3.36) and SF (4.51 +/- 3.62), while GIT data (1.01 +/- 0.51) are significantly underestimated. In conclusion, our preliminary results have evidenced a good reliability of the new test, the continuous infusion causing a steady gradient in V and A that more precisely reflects the AR rate. PMID:20383860

Bosticardo, Gian Mario; Morellini, Veronica; Schillaci, Enrico; Battisti, Marco; Norza, Massimo; Detoma, Paolo; Forneris, Giacomo; Filiberti, Oliviero; Bajardi, Pietro

2010-01-01

342

Protocol-directed insulin infusion sliding scales improve perioperative hyperglycaemia in critical care  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Perioperative hyperglycaemia is associated with poor outcomes in patients undergoing cardiac surgery. Frequent postoperative hyperglycaemia in cardiac surgery patients has led to the initiation of an insulin infusion sliding scale for quality improvement. A systematic review was conducted to determine whether a protocol-directed insulin infusion sliding scale is as safe and effective as a conventional practitioner-directed insulin infusion sliding scale, within target blood glucose ranges. A literature survey was conducted to identify reports on the effectiveness and safety of an insulin infusion protocol, using seven electronic databases from 2000 to 2012: MEDLINE, CINAHL, EMBASE, the Cochrane Library, the Joanna Briggs Institute Library and SIGLE. Data were extracted using pre-determined systematic review and meta-analysis criteria. Seven research studies met the inclusion criteria. There was an improvement in overall glycaemic control in five of these studies. The implementation of protocols led to the achievement of blood glucose concentration targets more rapidly and the maintenance of a specified target blood glucose range for a longer time, without any increased frequency of hyperglycaemia. Of the seven studies, four used controls and three had no controls. In terms of the meta-analysis carried out, four studies revealed a failure of patients reaching target blood glucose levels (P P It can be concluded that the protocol-directed insulin infusion sliding scale is safe and improves blood glucose control when compared with the conventional practitioner-directed insulin infusion sliding scale. This study supports the adoption of a protocol-directed insulin infusion sliding scale as a standard of care for post-cardiac surgery patients.

Hui Man

2012-10-01

343

Use of technetium-99m hexamethylpropylene amine oxime SPET for the study of cerebral blood flow reactivity after acetazolamide infusion in patients with Behcet's disease  

International Nuclear Information System (INIS)

The purpose of this study was to characterise the nature of the baseline perfusion defects found in patients with Behcet's disease using hexamethylpropylene amine oxime single-photon emission tomography in conjunction with acetazolamide test (Acz SPET). Eleven patients underwent both baseline and Acz SPET. Regions of interest (ROIs) were drawn on the areas with decreased perfusion (D-ROI) and, in the same section, on areas with normal perfusion (N-ROI). The ROIs were then repositioned on the corresponding section on Acz SPET. The mean ROI counts were then transformed into a perfusion index value (PIV) with reference to the global brain counts. In total we found 24 D-ROIs (17 in the cortical and 7 in subcortical grey matter). The influence of Acz infusion was selectively registered in the D-ROIs, where PIVs changed from 1.23±0.17 (baseline SPET) to 1.63±0.23 (Acz SPET) (P<0.001). No significant difference was seen in the N-ROIs (1.46±0.21 and 1.40±0.17, respectively, on baseline SPET and Acz SPET). Our results demonstrate that Acz infusion increases the regional cerebral blood flow within baseline grey matter perfusion defects. This finding suggests that baseline perfusion abnormalities could reflect a disconnection rather than local vasculitic involvement. (orig.)

344

Mesenchymal stem cells are short-lived and do not migrate beyond the lungs after intravenous infusion  

OpenAIRE

Mesenchymal stem cells (MSC) are under investigation as a therapy for a variety of disorders. Although animal models show long term regenerative and immunomodulatory effects of MSC, the fate of MSC after infusion remains to be elucidated. In the present study the localization and viability of MSC was examined by isolation and re-culture of intravenously infused MSC. C57BL/6 MSC (500,000) constitutively expressing DsRed-fluorescent protein and radioactively labeled with Cr-51 were infused via ...

Eggenhofer, E.; Benseler, V.; Kroemer, A.; Popp, F. C.; Geissler, E. K.; Schlitt, H. J.; Baan, C. C.; Dahlke, M. H.; Hoogduijn, M. J.

2012-01-01

345

Tolerability of Shortened Infliximab Infusion in Scheduled Maintenance Therapy for IBD: A Prospective Multi-center European Cohort Study  

Directory of Open Access Journals (Sweden)

Full Text Available AIM: Although an infusion time of at least one hour is mandatedby the European label for infliximab (IFX maintenance treatmentof patients with IBD, shorter infusion times of 30 min have beenreported with low dose treatment in rheumatoid arthritis. The aim ofthis study was to prospectively evaluate the tolerability of shortenedIFX infusions in a multi-center cohort study.METHODS: Adults with Crohn’s disease or ulcerative colitistolerating at least seven IFX infusions (5 mg/kg of which at least3 infusions over one hour, without infusion reactions, were invitedto receive the same dose in 30 min for four consecutive infusionsand with the same dosing frequency. The primary endpoint was theproportion of patients completing the trial without a severe infusionreaction. Tolerability, infusion times and total procedure times,clinical disease activity and patient preference was assessed at everyinfusion.RESULTS: One hundred eleven (25 UC, 84 CD, 2 IBD-unclassifiedpatients enrolled in the trial. All shortened, 30 minute infusions werecompleted by 91/111 (83% patients and no severe infusion reactionswere observed. Mild to moderate reactions occurred in 10/111patients (6 acute and twenty terminated before week 24; infusionreactions (11, increased dosing of IFX (4, loss of efficacy (4 and 1patient moved out of the country. Median clinical activity indices andCRP remained stable throughout the study.CONCLUSION: In a selected population of patients with IBD,who have tolerated IFX maintenance infusions, infusion times canbe shortened from one hour to 30 min. No severe infusion reactionswere observed.

Ragnar Befrits

2013-06-01

346

Prevention of bedrest-induced physical deconditioning by daily dobutamine infusions. Implications for drug-induced physical conditioning.  

OpenAIRE

The effects of intermittent infusions of dobutamine were studied in young normal male subjects during a period of bedrest deconditioning to determine whether this synthetic catechol affects physical conditioning processes in humans. 24 volunteers were placed at bedrest and randomized to daily 2-h treatments of saline infusions (control), dobutamine infusions, or maintenance exercise (control). Exercise, hemodynamic, and metabolic studies were performed at base line and at the termination of t...

Sullivan, M. J.; Binkley, P. F.; Unverferth, D. V.; Ren, J. H.; Boudoulas, H.; Bashore, T. M.; Merola, A. J.; Leier, C. V.

1985-01-01

347

Shifting Perspectives and Practices: Teacher Candidates’ Experiences of a First Nation, Métis, and Inuit Infusion in Mainstream Teacher Education  

OpenAIRE

This exploratory case study shares teacher candidates’ perspectives and experiences of the First Nation, Métis, and Inuit Infusion at ABC University’s Faculty of Education field site in XYZ, Ontario. For this initiative, Aboriginal content and pedagogies were infused throughout placements and courses of the mainstream teacher education program. Teacher candidates shared that the Infusion prepared them to teach Aboriginal content in culturally respectful and meaningful ways by pr...

Melissa Marilyn Fern Blimkie; Diane Vetter; Celia Haig-Brown

2014-01-01

348

Prolonged Infusion of Angiotensin II in apoE?/? Mice Promotes Macrophage Recruitment with Continued Expansion of Abdominal Aortic Aneurysm  

OpenAIRE

Angiotensin II (AngII) infusion initiates abdominal aortic aneurysm (AAA) development due to medial disruption and results in luminal dilation and thrombus formation. The objective of this study was to determine whether AAA progressed during protracted AngII infusion. Male apoE?/? mice were infused with AngII using miniosmotic pumps. On day 27, suprarenal aortic luminal diameters were ultrasonically measured to identify mice exhibiting AAAs. Mice were designated to three groups with simil...

Rateri, Debra L.; Howatt, Deborah A.; Moorleghen, Jessica J.; Charnigo, Richard; Cassis, Lisa A.; Daugherty, Alan

2011-01-01

349

Urokinase Lysis for Acute Left Subclavian Artery Thrombosis after Placement of Infusion Catheter: Report of Two Cases  

International Nuclear Information System (INIS)

We present two cases of acute subclavian and/or axillary arterial occlusion after transaxillary catheterization with an implantable port for hepatic arterial infusion chemotherapy. They were successfully treated with thrombolytic therapy using intraarterial administration of urokinase without removal of the infusion catheter system. We consider that this treatment is suitable for managing acute thrombosis of the conduit artery after catheterization for hepatic arterial infusion chemotherapy

350

The flavonoids casticin and artemetin are poorly extracted and are unstable in an Artemisia annua tea infusion  

OpenAIRE

A number of flavonoids including casticin and artemetin from Artemisia annua have shown synergism with artemisinin against Plasmodium falciparum, but it is unclear if flavonoids are also extracted into a tea infusion of the plant. Using a tea infusion preparation protocol that was reported to be highly effective for artemisinin extraction, we measured casticin and artemetin extraction. There was only a 1.8% recovery of casticin in the infusion while artemetin was undetectable. After 24 hr sto...

Weathers, Pj; Towler, Mj

2012-01-01

351

Radiosensitization By Gemcitabine Fixed-Dose-Rate Infusion Versus Bolus Injection in a Pancreatic Cancer Model1  

OpenAIRE

It has recently been shown that fixed-dose-rate (gemcitabine) infusion may be superior to bolus gemcitabine in the treatment of metastatic pancreas cancer. We wished to compare the radiosensitizing effects of fixed-dose-rate gemcitabine infusion to standard bolus injection. We measured weight loss and mouse intestinal crypt survival to determine equally toxic concentrations of gemcitabine administered through a 3-hour fixed-dose-rate infusion versus bolus injection in combination with fractio...

Morgan, Meredith; El Shaikh, Mohamed A.; Abu-isa, Eyad; Davis, Mary A.; Lawrence, Theodore S.

2008-01-01

352

Duration and distribution of experimental muscular hyperalgesia in humans following combined infusions of serotonin and bradykinin  

DEFF Research Database (Denmark)

The present study examined distribution and duration of muscle hyperalgesia to pressure stimuli after intramuscular bolus-infusions of serotonin (5-HT, 20 nmol) and bradykinin (BKN, 10 nmol) in 10 volunteers. Infusions were given into the tibialis anterior (TA) muscle over 20 s with an inter-infusions interval of 3 min. Infusions of isotonic saline (NaCl, 0.9%) were given as control. Pain intensity was continuously scored on a visual analogue scale (VAS), and subjects drew the distribution of the pain areas on an anatomical map. Pressure pain thresholds (PPTs) were assessed with an electronic algometer at the injection site (10 cm below the patella), 2, 5, and 10 cm distal from the injection site, and at the ankle. Control assessments of PPTs were done at the contralateral TA and ankle. Skin sensibility was assessed with a Von Frey hair at the same sites. All measurements were done before and 5, 20, 40, and 60 min after infusions. The VAS-peak after BKN was significantly higher (P<0.05) compared with 5-HT andthe second infusion of NaCl. The duration of the increase in VAS after 5-HT+BKN was significantly longer (P<0.05) compared with the infusions of NaCl. The local pain area after infusion of BKN was significantly larger (P<0.05) compared with 5-HT and control infusions. Cutaneous sensibility to tactile stimuli was not affected by any of the combinations. PPTs at the injection site and 2 cm (5, 20, and 40 min) were significantly decreased (P<0.05) after 5-HT+BKN compared with baseline and isotonic saline. In addition, PPTs were significantly decreased (P<0.05) after 5-HT+BKN at 5 cm (5 and 20 min) and 10 cm (5 min). Serotonin may enhance the effect of bradykinin in producing experimental muscle pain and muscle hyperalgesia to mechanical stimuli. The combination of serotonin and bradykinin can produce muscle hyperalgesia, lasted for up to 40 min and located within the muscle. No widespread hyperalgesia to the ankle and other leg (tested at 10 cm below the patella and ankle) was observed suggesting a predominant peripheral origin of the experimentally induced hyperalgesic stage.

Babenko, Victor; Svensson, Peter

2000-01-01

353

Renal effects of multiple infusion of pyridoxalated-hemoglobin-polyoxyethylene conjugate (PHP) solution in dogs.  

Science.gov (United States)

Pyridoxalated-hemoglobin-polyoxyethylene conjugate (PHP), which is made from out-dated human red blood cells by two major chemical modifications, namely pyridoxalation and conjugation with polyoxyethylene (POE), is currently under development as a physiological oxygen carrier. This study assessed the effects of PHP-88 solution, which contains 8% (wt/vol) each of hemoglobin (Hb) and maltose, on renal function when it was infused 3 times every other day into the intact circulation of 8 dogs (5 dogs for the PHP group and 3 for the control group; 20 ml/kg for the first infusion, and 10 ml/kg each for the second and third infusions, at the rate of 2.5 ml/h/kg). Serial determinations of glomerular filtration rate (GFR) and renal plasma flow (RPF) were carried out pre- and postinfusion for up to 3 months along with measurements of blood and urine analyses, urine output rate, fractional excretion of sodium (FES), and free water clearance (CH2O). The results showed that plasma colloid osmotic pressure (COP) elevated an average of 3.3 mm Hg (p = 0.0085), and GFR and RPF tended to increase by 13% (NS) and 38% (NS), respectively, immediately after the third infusion with PHP solution. Urine output rate increased during and after the infusion, and FES and CH2O also increased for 24 h after the infusion in both groups. Blood urea nitrogen, serum creatinine, and serum Na+ concentrations were not affected greatly by the infusions, but hematocrit was decreased by 8% in the PHP group, indicating approximately a 42% expansion of plasma volume. These changes were observed to return to their preinfusion levels by 1 week postinfusion. Renal histology of the PHP group obtained at 2 weeks postinfusion revealed vacuole formation in the proximal tubules which was not associated with any pathologic changes indicative of cell death or regeneration. In 4 out of 5 dogs at 3 months postinfusion (necropsy), the vacuoles were not present. Though urinary N-acetyl-beta-glucosaminidase (NAG) activity had significantly increased after infusion, it returned to the preinfusion level by 1 month postinfusion. No detrimental effect of vacuoles on the assessed renal tubular functions was confirmed in the present study. The results demonstrated that multiple infusions of PHP solutions were well tolerated in normal dogs, and the observed effects were conceived predominantly attributable to the physiological response of the kidneys to an oncotic load into the circulation, which produced plasma volume expansion. PMID:8215940

Takahashi, T; Iwasaki, K; Malchesky, P S; Harasaki, H; Matsushita, M; Nosé, Y; Rolin, H; Hall, P M

1993-03-01

354

Contribution of 99mTc-sestamibi infusion SPECT to the characterization of fixed perfusion defects  

International Nuclear Information System (INIS)

In patients with coronary artery disease, the distinction between scar and viable myocardium by means of myocardial perfusion imaging (MPI) sometimes can be difficult because of the equivocal meaning of fixed perfusion defects. In this study we examined whether addition of a 99mTc-sestamibi infusion study to the standard MPI could provide extra information regarding the fixed defects. Thirty-seven patients underwent standard MPI and an extra SPECT study in which 99mTc-sestamibi was given as a prolonged constant infusion. Of 324 myocardial segments available for analysis, 134 had fixed or resting perfusion abnormalities on standard MPI studies, of which 25% (33/134) in 12 patients showed partial improvement in the perfusion pattern whereas in 6% (8/134) the improvement was very significant in infusion studies. In 19 patients who were also examined with dobutamine echocardiography, 13 showed concordance between echocardiography and infusion MPI. This study suggests that infusion MPI may provide complementary information to the conventional scintigraphy with regard to interpretation of standard myocardial perfusion scans with fixed defects. (author)

355

Insulin compatibility with polymer materials used in external pump infusion systems.  

Science.gov (United States)

In a study designed to mimic actual user conditions for external insulin pump infusion, the insulin quality after passage through the infusion set was assessed by various analytical methods, including high performance liquid chromatography. The two infusion sets tested consisted of, firstly, a polyvinylchloride/rubber syringe and a polyvinylchloride catheter sterilized by gamma irradiation and, secondly, a polyethylene/polypropylene syringe connected to a polyethylene catheter and sterilized by ethylene oxide. The insulin solution delivered through the PVC infusion set showed a reduction of preservative to less than 30% of the initial content and increased formation of chemical transformation products of insulin varying from twice the reference level during the first day to more than three times on the third day. By contrast, the polyethylene/polypropylene infusion system showed only a minor decrease in preservative content and no increase in chemical transformation. These effects were observed irrespective of the brand of insulin and were not affected by increase of the zinc content of the insulin solution. Investigation of the influence of the sterilization methods performed on polyvinylchloride and polyethylene catheters revealed that gamma irradiated polyvinylchloride catheters were markedly harmful to the insulin solution, whereas ethylene oxide sterilization did not influence the chemical stability of insulin. PMID:2967145

Melberg, S G; Havelund, S; Villumsen, J; Brange, J

1988-04-01

356

Inositol lipid metabolism in vasopressin stimulated hepatocytes from rats infused with tumor necrosis factor  

International Nuclear Information System (INIS)

We studied the effect of i.v. infusion of human recombinant tumor necrosis factor alpha (rHuTNF alpha, Cetus, 15 micrograms/100 g bw over 3 h) on vasopressin (VP)-stimulated 32P-inositol lipid turnover and the release of 3H-inositol phosphates in isolated rat hepatocytes. The early VP-induced decrease (within 30 s) in 32P-phosphatidylinositol 4-phosphate and 32P-phosphatidylinositol 4,5-bisphosphate labeling was significantly reduced (-40%) and at the same time the uptake of 32P into phosphatidic acid was 50% lower than in saline-infused (matched control) rats. Within 5 min of VP-stimulation, lower 32P phosphatidylinositol (-40%) and higher 32P-phosphatidic acid (+30%) labeling were observed in rHuTNF alpha-infused rats. Infusion of rHuTNF alpha also affected the VP-induced release of 3H-inositol phosphates. The accumulation of 3H-inositol-labeled water soluble products was decreased by 25% and 17% at 30 s and 10 min, respectively. These data show that rHuTNF alpha mimics early perturbations induced by Escherichia coli endotoxin infusion in VP-stimulated inositol lipid metabolism in rat hepatocytes

357

Antioxidant Activity of Oak (Quercus Leaves Infusions against Free Radicals and their Cardioprotective Potential  

Directory of Open Access Journals (Sweden)

Full Text Available The aim of present study was to evaluate antioxidant capacity and cardioprotective potential of leaves infusions and partially purified fractions of Quercus sideroxyla and Q. eduardii (red oaks and Q. resinosa (white oak. Consumption of polyphenol-rich beverages derived from plants, such as oak may represent a beneficial diet in terms of cardiovascular protection. Infusions from Oak leaves were obtained and probed for total phenolics by Folin-Ciocalteu, DPPH and hydroxyl radicals scavenging by DPPH test and Deoxy-D-ribose method, the antioxidant capacity was evaluated by FRAP and ORAC tests, inhibitions of Low Density Lipoproteins (LDL oxidation and Angiotensin Converting Enzyme (ACE activity were measured. A HPLC analysis was performed by HPLC-MS. Bioactive polyphenols such as gallic and ellagic acids, catechin, quercetin and derivatives: naringenin and naringin were detected in Quercus infusions. A distinctive HPLC profile was observed among the red and white oak samples. Q. resinosa infusions have exhibited the highest antioxidant activity in comparison with the other species, although in the inhibition of LDL oxidation no differences were observed. In the inhibition of the ACE, Q. resinosa was more effective (IC50, 18 ppm than Q. sideroxyla, showing same effect as the control Captopril. From the results it is possible to postulate that not only chelating activity is important in these infusions, especially in Q. resinosa.

Rong (Tsao Cao

2010-01-01

358

Infusion of allogeneic umbilical cord blood hematopoietic stem cells in patients with chemotherapy-related myelosuppression.  

Science.gov (United States)

Chemotherapy-induced myelosuppression is one of the main problems in the treatment of cancer. In the present study, the effects of allogeneic umbilical cord blood hematopoietic stem cell (UCB-HSC) infusion were investigated on the treatment of chemotherapy-related myelosuppression. In total, 65 patients (male, 42; female, 23) diagnosed with chemotherapy-related myelosuppression were included in the study. The majority of the patients were classified with stage II myelosupression at enrolment, and an average concentration of 7.07×10(9)/l UCB-HSCs were transfused through the peripheral vein. The minimum values of the white blood cell (WBC) count, hemoglobin (Hb) level, platelet (PLT) count and Karnofsky performance status (KPS) scores were recorded prior to and between days 7 and 14 following UCB-HSC infusion. When assessing the overall data, the results revealed that the mean WBC and PLT counts increased significantly following UCB-HSC infusion. However, the subgroup analyses based on gender and KPS score revealed that UCB-HSC infusion was more successful in male patients and those with a higher KPS score. Spearman's correlation analysis revealed a linear correlation between the number of transfused UCB-HSCs and the changes in the WBC and PLT counts following treatment. In conclusion, the results indicated that peripheral vein infusion of non-human leukocyte antigen matched UCB-HSCs can markedly improve chemotherapy-related myelosuppression in a safe and effective manner. PMID:25371761

Yao, Yi; Song, Qibin; Chu, Yuxin; Gong, Hongyun; Li, Na; Hu, Qinyong; Xu, Xiaotao

2014-12-01

359

Insulin secretion and cellular glucose metabolism after prolonged low-grade intralipid infusion in young men  

DEFF Research Database (Denmark)

We examined the simultaneous effects of a 24-h low-grade Intralipid infusion on peripheral glucose disposal, intracellular glucose partitioning and insulin secretion rates in twenty young men, by 2-step hyperinsulinemic euglycemic clamp [low insulin clamp (LI), 10 mU/m(2) x min; high insulin clamp (HI), 40 mU/m(2) x min], 3-(3)H-glucose, indirect calorimetry, and iv glucose tolerance test. Free fatty acid concentrations were similar during basal steady state but 3.7- to 13-fold higher during clamps. P-glucagon increased and the insulin/glucagon ratio decreased at both LI and HI during Intralipid infusion. At LI, glucose oxidation decreased by 10%, whereas glucose disposal, glycolytic flux, glucose storage, and glucose production were not significantly altered. At HI, glucose disposal, and glucose oxidation decreased by 12% and 24%, respectively, during Intralipid infusion. Glycolytic flux, glucose storage, and glucose production were unchanged. Insulin secretion rates increased in response to Intralipid infusion, but disposition indices (DI = insulin action.insulin secretion) were unchanged. In conclusion, a 24-h low-grade Intralipid infusion caused insulin resistance in the oxidative (but not in the nonoxidative) glucose metabolism in young healthy men. Moreover, insulin hypersecretion perfectly countered the free-fatty acid-induced insulin resistance. Future studies are needed to determine the role of a prolonged moderate lipid load in subjects at increased risk of developing diabetes.

Jensen, Christine B; Storgaard, Heidi

2003-01-01

360

Insulin secretion and cellular glucose metabolism after prolonged low-grade intralipid infusion in young men.  

DEFF Research Database (Denmark)

We examined the simultaneous effects of a 24-h low-grade Intralipid infusion on peripheral glucose disposal, intracellular glucose partitioning and insulin secretion rates in twenty young men, by 2-step hyperinsulinemic euglycemic clamp [low insulin clamp (LI), 10 mU/m(2) x min; high insulin clamp (HI), 40 mU/m(2) x min], 3-(3)H-glucose, indirect calorimetry, and iv glucose tolerance test. Free fatty acid concentrations were similar during basal steady state but 3.7- to 13-fold higher during clamps. P-glucagon increased and the insulin/glucagon ratio decreased at both LI and HI during Intralipid infusion. At LI, glucose oxidation decreased by 10%, whereas glucose disposal, glycolytic flux, glucose storage, and glucose production were not significantly altered. At HI, glucose disposal, and glucose oxidation decreased by 12% and 24%, respectively, during Intralipid infusion. Glycolytic flux, glucose storage, and glucose production were unchanged. Insulin secretion rates increased in response to Intralipid infusion, but disposition indices (DI = insulin action.insulin secretion) were unchanged. In conclusion, a 24-h low-grade Intralipid infusion caused insulin resistance in the oxidative (but not in the nonoxidative) glucose metabolism in young healthy men. Moreover, insulin hypersecretion perfectly countered the free-fatty acid-induced insulin resistance. Future studies are needed to determine the role of a prolonged moderate lipid load in subjects at increased risk of developing diabetes.

Jensen, Christine B; Storgaard, Heidi

2003-01-01

361

Proximal tubular function and hyperfiltration during amino acid infusion in man.  

Science.gov (United States)

The relations between renal hemodynamics (Inutest, CPAH) and sodium segmental handling (sodium distal delivery, distal reabsorption, and fractional excretion) were studied in 9 healthy adults infused with an isotonic amino acid solution and in 6 subjects infused with 0.9% saline for 3 h at 0.2 ml/min/kg. During all tests maximal water diuresis was induced and maintained to effect analysis of sodium segmental transport. Both types of infusion produced a similar expansion of extracellular volume (weight increase, hematocrit fall, suppressed plasma renin activity and plasma aldosterone). The amino acid infusion increased the glomerular filtration rate (GFR) and renal blood flow without modifying the filtration fraction. With saline no hemodynamic modifications were observed. The expansion with saline depressed proximal and distal sodium reabsorption whereas during amino acid infusion sodium distal delivery was unaltered and the significantly increased sodium fractional excretion was sustained only by depressed distal reabsorption. Therefore, in parallel with the GFR increase, closely dependent on renal vasodilatation, the well-known stimulation of sodium cotransport by amino acids is able to antagonize the effects of expansion on the proximal sodium reabsorption. An explanation of glomerular hyperfiltration based on a primary metabolic stimulation of the proximal tubular function is suggested. PMID:3394727

Claris-Appiani, A; Assael, B M; Tirelli, A S; Cavanna, G; Corbetta, C; Marra, G

1988-01-01

362

Apoptosis and histological response of preoperative intraarterial chemotherapy infusion for colorectal carcinoma  

International Nuclear Information System (INIS)

Objective: To investigate apoptosis and histological response of preoperative intraarterial chemotherapy infusion for colorectal carcinoma. Methods: Fifty patients with colorectal carcinoma were treated by intraarterial infusion of anti-cancer drugs. Surgical resection of the tumor was performed 5-30 days after the intraarterial infusion (mean 12 days). The histological response was evaluated. The density and distribution of the apoptosis cells were observed by DNA nick end labelling technique. 22 biopsy specimens before the intraarterial chemotherapy and 25 normal mucosa (obtained from surgery specimen) were used as controls. Results: The total histological response rate was 100% with grade I in 20 cases, grade II in 21 cases, and grade III in 9 cases. The density of the apoptosis cells was 31.47±5.58 before and 76.69±17.12 after the intraarterial chemotherapy infusion, and 8.01±3.39 in normal mucosa, respectively. The density of the apoptosis cells after the intraarterial chemotherapy was significantly higher than that before the intraarterial chemotherapy (t=13.701, P2=4.696, P>0.30). The apoptosis of adenocarcinoma was significantly differennocarcinoma was significantly different with different histological response (F=7.73, P0.05) and for adenocarcinoma with different pathological stages (F=0.001376, P>0.05). Conclusion: As an effective and safe procedure, preoperative transcatheter intraarterial chemotherapy infusion achieves a significant histological response and apoptosis in colorectal adenocarcinoma

363

[The postoperative analgesic effects of magnesium infusion on brachial plexus block].  

Science.gov (United States)

Magnesium sulphate infusion decreases analgesic requirements after general anesthesia. Aim of this study was to assess the effects of postoperative magnesium infusion for 24 hours on duration of the block, sedation and postoperative analgesic consumption after brachial plexus block. After obtaining approval from local ethic committee, 70 ASA class I and II patients were included to the randomised double blind study. Brachial plexus block was performed using axillary approach with lignocaine 1.25% adrenaline 1/200 000 40 ml. Groups received 5 mg/kg bolus and 500 mg/h magnesium sulphate infusion or saline controls at the same volume during 24 hour. Analgesia and sedation were assessed while determining time to first pain and rescue analgesic, time to regain motor capability, visual analogue scale and sedation scores for every 4 hour during postoperative 24 h. period. While time to first pain and rescue analgesic was increased, total analgesic consumption was reduced significantly on magnesium infusion group (Meperidine: C: 36.3 +/- 42.6 mg, Mg: 11.7 +/- 12.2 mg, p: 0.001). Visual analogue scales were also observed to be lower in all periods. Time to motor block resolution, and sedation scores were similar. Magnesium sulphate infusion is thought as a safe and suitable adjunct for reducing analgesic consumption and possible complications without interfering daily activity in patients undergoing brachial plexus block. PMID:18095196

Anbarci, Ozlem; Apan, Alparslan; Sahin, Saziye

2007-07-01

364

Chronic ICV infusion of neuropeptides alters lymphocyte populations in experimental rodents.  

Science.gov (United States)

The sympathetic nervous system has been shown to influence immune function. Angiotensin II and substance P are two neurally active peptides that have been shown to increase sympathetic nervous system activity when injected centrally. Using osmotic minipumps, we chronically infused angiotensin II (1 microgram/h) and substance P (2 micrograms/h) into the brains of intact Sprague-Dawley rats for a period of 1 month and 2 weeks, respectively. Age-matched control animals were infused with artificial cerebrospinal fluid. We then examined the effect of this infusion on the percentage of different lymphocyte populations in the peripheral blood. The angiotensin II infused animals showed an increase in the percentage of total T-cells and a decrease in the percentage of B-cells relative to controls. The substance P treated animals also showed an increase in the percentage of T-cells present, but failed to show the decrease in the B-cell population seen with the angiotensin II infused group. This study shows that the central nervous system can influence the immune system. As shown in this study, these effects are most likely mediated via the sympathetic nervous system. These results add to the expanding body of data suggesting an important role of the central nervous in regulating immune function and our susceptibility to disease. PMID:1718015

Fannon, L D; Phillips, M I

1991-07-01

365

Direct vs. indirect pathway of hepatic glycogen synthesis as a function of glucose infusion rate  

International Nuclear Information System (INIS)

This study was initiated to determine the influence of the rate of exogenous glucose administration on liver glycogen synthesis by the direct (glucose uptake and incorporation into glycogen) vs the indirect pathway (glucose degradation to 3-carbon intermediates, e.g., lactate, prior to incorporation into glycogen). Catheterized rats were fasted 2 days prior to receiving a 3 hr infusion of glucose at rates of 0 to 230 ?mol/min/kg containing tracer [6-3H]- and [U-14C]-glucose. Plasma glucose (r = 0.80), insulin (r = 0.90) and lactate (r = 0.84) were correlated with glucose infusion rate. The rate of liver glycogen deposition (0.46 +/- 0.03 ?mol/min/g) did not differ between a glucose infusion rate of 20 and 230 ?mol/min/kg. At the lowest and highest glucose infusion rates hepatic glycogenesis accounted for 87 +/- 6 and 9 +/- 1% of the total glucose load, respectively. The percent contribution of the direct pathways to glycogen deposition ([3H] specific activity in hepatic glycogen/[3H] specific activity in plasma glucose) increased from 16 +/- 3 to 83 +/- 5% from lowest to highest glucose infusion rates (prevailing plasma glucose concentrations: 9 +/- 1 and 21 +/- 2 mM, respectively). The results indicate that the relative contribution of the direct and indirect pathways of glucogen synthesis are dependent upon the glucose load or plasma glucose concentration

366

Chronic intrastriatal dopamine infusions in rats with unilateral lesions of the substantia nigra  

International Nuclear Information System (INIS)

This study examined the effects of continuously supplied dopamine delivered directly into the dopamine-deficient striatum. Rats received unilateral lesions of the substantia nigra by stereotaxic administration of 6-hydroxydopamine and were tested for apomorphine-induced rotational behavior and general activity. Osmotic mini-pumps were filled with dopamine in various concentrations, implanted subcutaneously and connected to a cannula implanted directly into the striatum. The system delivered solution at a rate of .5 ?l/hr for two weeks. Dopamine in a dosage of 0.5 ?g/per hour reduced apomorphine-induced rotational behavior by a mean of 52 +/- 5.8% (mean +/- SEM n=20) with a maximal individual decrease of 99%. There was no change in general activity or increase in stereotype behavior. Infusions of vehicle solutions did not decrease rotational behavior. Spread of the infused dopamine and its metabolites was estimated by adding 3H-dopamine to the pumps in tracer quantities. Radioactivity was highly concentrated at the infusion site and decreased rapidly within a few mm from the infusion site. Continuous infusion methods may eventually prove to be effective in the treatment of nigro-striatal degenerative disease. 12 references, 4 figures

367

Trioctanoin infusion increases in vivo leucine oxidation: a lesson in isotope modeling  

International Nuclear Information System (INIS)

We have reported that infusion of trioctanoin in conscious dogs had little effect on leucine oxidation but decreased the rate of appearance (Ra) and interconversion of leucine and its alpha-keto acid, alpha-ketoisocaproate (KIC). To verify that these conclusions were independent of the leucine tracers and isotope models employed, the studies were repeated using [1-14C]leucine and [4,5-3H]KIC rather than [1-14C]KIC and [4,5-3H]leucine. In the present study, leucine oxidation calculated using the plasma [14C]leucine or [14C]KIC specific activities (SA) increased nearly twofold (P less than 0.001) during trioctanoin infusion in direct contrast to our previous results. When the data from either study were analyzed using the plasma SA of the leucine moiety reciprocal to the infused tracer as a potential indicator of the intracellular leucine SA, similar conclusions were obtained from either study: trioctanoin infusion in conscious dogs appears to increase whole-body leucine oxidation and does not decrease proteolysis. These studies challenge the validity of previously used isotope models of leucine metabolism and suggest that the plasma KIC SA during infusion of labeled leucine may most accurately reflect changes in whole-body leucine metabolism

368

Recycling of an amino acid label with prolonged isotope infusion: Implications for kinetic studies  

International Nuclear Information System (INIS)

To investigate whether recycling of a labeled amino acid would occur after 24 h of infusion, two groups of normal volunteers were infused with [3H]leucine and alpha-[14C]-ketoisocaproate for 4 h and [2H3]leucine for either 4 or 24 h (groups I and II, respectively). Entry of [2H3]leucine at steady state into the plasma space was indistinguishable from its infusion rate for group I but 30% higher (P less than 0.001) than this rate for group II, demonstrating significant recycling of label. After discontinuation of the infusions, isotope disappearance from the plasma space was followed for 2 h. The 3H and 14C decay data for both groups suggest that plasma leucine and alpha- ketoisocaproate are derived from a single intracellular pool in the postabsorptive state. In group I, the 3H and 2H labels decayed identically; whereas, in group II, the decay of [2H3]-leucine and alpha- [2H3]ketoisocaproate was slower (P less than 0.01) than the decay of [3H]leucine and alpha-[3H]ketoisocaproate, confirming re-entry of label after a 24-h infusion. Therefore kinetic values calculated from models assuming no recycling of labeled amino acids are most likely not quantitative and must be interpreted with care when flux does not change or decreases

369

Materials Characterisation and Analysis for Flow Simulation of Liquid Resin Infusion  

Science.gov (United States)

Liquid Resin Infusion (LRI) processes including VARI and VARTM have received increasing attention in recent years, particularly for infusion of large parts, or for low volume production. This method avoids the need for costly matched metal tooling as used in Resin Transfer Moulding (RTM) and can provide fast infusion if used in combination with flow media. Full material characterisation for LRI analysis requires models for three dimensional fabric permeability as a function of fibre volume content, fabric through-thickness compliance as a function of resin pressure, flow media permeability and resin viscosity. The characterisation of fabric relaxation during infusion is usually determined from cyclic compaction tests on saturated fabrics. This work presents an alternative method to determine the compressibility by using LRI flow simulation and fitting a model to experimental thickness measurements during LRI. The flow media is usually assumed to have isotropic permeability, but this work shows greater simulation accuracy from combining the flow media with separation plies as a combined orthotropic material. The permeability of this combined media can also be determined by fitting the model with simulation to LRI flow measurements. The constitutive models and the finite element solution were validated by simulation of the infusion of a complex aerospace demonstrator part.

Sirtautas, J.; Pickett, A. K.; George, A.

2014-08-01

370

The contamination of intravenous fluids by writing on the infusion bag: Fact or fiction?  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction -Laboratory experiments were conducted to ascertain whether Sharpie® brand black permanent marker ink will permeate through intravenous infusion bags. The practice of writing directly on infusion bags is a frequent yet controversial practice. There are no known written standards that exist which pertain to this practice. Methods – Five types of intravenous bags containing different solutions marked with black ink from a fine point felt tipped Sharpie® marker. Sample extraction occurred after infusion bags had been warmed to 40 C or remained ambient.  Spectrophotometric scans and measurements were conducted at 300 to 600 NM on each solution contained in the experimental bags. Writing with Sharpie® pens on filter paper and surgical tape was also conducted. Results – A total of 17 experiments were conducted with intravenous bags of five different types of manufacture.  There appeared to be no visible or ultraviolet spectrophotometric evidence of leaching of the ink from Sharpie® pens. Four different lot numbers of Sharpie® pens were used. Surgical tape that was written on using Sharpie® markers readily exhibited visible evidence of permeability. Discussion - The experiments conducted would appear to indicate that the infusion containers tested maintained an intact barrier to the application of Sharpie® brand permanent marker ink. Writing on surgical tape does not stop the permeability of Sharpie® pens. This study could serve as a suitable pilot study for others to conduct a much more comprehensive study using a greater number of intravenous containers, solutions and ink markers.   Keywords: Fluid therapy, infusion, ink, intravenous, writing.

James Daniel Langston

2013-11-01

371

UJI KHASIAT ANTIDIARE INFUS DAUN JATI BELANDA (GUAZUMA ulmifolia LAMK. PADA TIKUS PUTIH  

Directory of Open Access Journals (Sweden)

Full Text Available Salah satu pemakaian empirik daun jati-belanda adalah sebagai obat mencret atau diare. Diketahui di dalam daun jati-belanda terkandung zat yang berperan sebagai astrigen yaitu menciutkan lapisan permukaan usus, sehingga mengurangi kepekaan sekresi yang dapat menekan peristaltik usus. Untuk mengetahui efek antidiare infus daun jati-belanda, telah dilakukan percobaan uji khasiat antidiare infus daun jati-belanda (Guazuma ulmifolia Lamk. menggunakan model tikus putih yang dibuat diare dengan pemberian minyak jarak. Infus daun jati-belanda diberikan secara oral dengan dosis 60 mg, 180 mg dan 600 mg/100 g bb. satu jam sebelum pemberian minyak jarak. Sebagai pembanding positif digunakan Loperamide HC1 dengan dosis 0,12 mg/100 g bb. serta akuades sebagai kontrol negatif. Hasil percobaan menunjukkan bahwa pemberian infus dengan dosis 60 mg dan 180 mg/100 g bb. memperlihatkan efek antidiare dibandingkan dengan akuades, tetapi bila dibandingkan dengan Loperamide kedua dosis tersebut efek antidiarenya lebih kecil. Infus dosis 600 mg/100 g bb. mempunyai efek antidiare yang hampir sama dengan Loperamide.   Kata kunci: Tanaman Obat, Jati-Belanda (Guazuma ulmifolia Lamk., Antidiare.

Dian Sundari

2012-09-01

372

Low flow measurement for infusion pumps: implementation and uncertainty determination of the normalized method  

International Nuclear Information System (INIS)

Intravenous drug delivery is a standard practice in hospitalized patients. As the blood concentration reached depends directly on infusion rate, it is important to use safe devices that guarantee output accuracy. In pediatric intensive care units, low infusion rates (i.e. lower than 10.0 ml/h) are frequently used. Thus, it would be necessary to use control programs to search for deviations at this flow range. We describe the implementation of a gravimetric method to test infusion pumps in low flow delivery. The procedure recommended by the ISO/IEC 60601-2-24 standard was used being a reasonable option among the methods frequently used in hospitals, such as infusion pumps analyzers and volumetric cylinders. The main uncertainty sources affecting this method are revised and a numeric and graphic uncertainty analysis is presented in order to show its dependence on flow. Additionally, the obtained uncertainties are compared to those presented by an automatic flow analyzer. Finally, the results of a series of tests performed on a syringe infusion pump operating at low rates are shown.

373

Phytochemical composition and antioxidant activity of Laurus nobilis L. leaf infusion.  

Science.gov (United States)

Laurus nobilis L. (laurel) leaves are frequently used as a spice for cooking purposes. Folk medicine in many countries uses the infusion of the plant in stomachic and carminative remedies, as well as for the treatment of gastric diseases. Little information is available about the phytochemical composition of the infusion of dried leaves, which is a way to consume this aromatic and medicinal plant. Phytochemical investigations on the infusion were performed by high-performance liquid chromatography (HPLC) with a diode array detector (DAD) and direct electrospray ionization-tandem mass spectrometry. Several flavonoid derivatives were detected. Semipreparative HPLC from the infusion of laurel leaves isolated 10 flavonoid O-glycosides, one flavonoid C-glycoside, catechin, and cinnamtannin B1. Structures of the isolated compounds were computed on the basis of spectral measurements including high-resolution mass spectrometry spectroscopy and one- and two-dimensional nuclear magnetic resonance techniques. The amount of the flavonoids was also determined by HPLC-DAD. The antioxidant activity of the tea and the isolated compounds was also measured using two different in vitro methods: the Briggs-Rauscher oscillating reaction test, at a pH similar to that of the gastric juice, and the Trolox equivalent antioxidant capacity assay, at the pH of blood. For the infusion and the methanol extract the total phenolic content was also measured using the Folin-Ciocalteu reagent. PMID:19735189

Dall'Acqua, Stefano; Cervellati, Rinaldo; Speroni, Ester; Costa, Stefano; Guerra, Maria Clelia; Stella, Laura; Greco, Emanuela; Innocenti, Gabbriella

2009-08-01

374

Safety of adenosine stress myocardial perfusion imaging by a one-route infusion protocol  

International Nuclear Information System (INIS)

When adenosine stress testing is performed, a vein is generally accessed in each arm. To determine whether the one-route infusion protocol, that is, infusion via one upper arm vein, is safe, myocardial perfusion imaging was performed during adenosine stress testing in patients with angina pectoris. Sixty-six consecutive patients (43 men, 68±11 years of age) with suspected coronary artery disease were enrolled in this study. For the stress test, adenosine was injected at 120 ?g/kg/min for 6 minutes. Systolic blood pressure, diastolic blood pressure, and heart rate did not show any significant changes after injection of the adenosine and radioisotope (RI) tracer. Adverse events during infusion of the adenosine were seen in 42 (64%) patients and included chest discomfort/oppression in 17 (26%) and dyspnea/throat discomfort in 15 (23%). On the other hand, adverse events just after infusion of the RI tracer occurred in 5 (8%) patients and included chest oppression in 2 (3%) and dyspnea in 1 (2%). Almost all adverse events disappeared quickly without treatment. Therefore, we concluded that adenosine stress myocardial perfusion imaging using a one-route infusion protocol is safe and useful to do for patients unable to secure veins in both arms. (author)

375

PENGARUH INFUS BUAH Foeniculum vulgare Mill PADA SIKLUS ESTRUS DAN BOBOT UTERUS TIKUS PUTIH  

Directory of Open Access Journals (Sweden)

Full Text Available Buah Foeniculum vulgare Mill (adas secara tradisional untuk obat dan campuran jamu pengatur haid. Diduga buah Foeniculum vulgare Mill mempunyai pengaruh pada sistem reproduksi. Oleh karena itu, kami melakukan penelitian pengaruh infus buah Foeniculum vulgare Mill pada siklus estrus dan bobot uterus tikus putih.Infus diberikan secara oral sekali sehari selama 12 hari dengan dosis setara dengan 7,3 mg, 73 mg dan 219 mg/100 g bobot badan. Selama pemberian bahan, siklus estrus diperiksa setiap hari dan pada hari ke-13 diotopsi dan ditimbang bobot uterusnya.Hasil penelitian menunjukkan bahwa infus buah Foeniculum vulgare Mill setara dengan serbuk 7,3 mg, 73 mg dan 219 mg/100 g bobot badan dapat menghambat fase estrus (masa subur. Infus setara dengan serbuk 7 mg dan 219 mg/100 g bobot badan kelihatan dapat menghambat fase estrus yang sangat nyata dibandingkan dengan akuades. Infus buah Foeniculum vulgare Mill setara dengan serbuk 219 mg/100 g bobot badan dapat menurunkan bobot uterus, tetapi secara statistik tidak berbeda nyata dengan akuades. Kata kunci: Obat tradisional; Foeniculum vulgare Mill; Sistem Reproduksi

Sa'roni Sa'roni

2012-10-01

376

The removal of infused leucine after injury, starvation and other conditions in man.  

Science.gov (United States)

1. To investigate the effects of starvation, elective surgery, accidental injury and other clinical conditions on the metabolism of branched-chain amino acids in man, we have measured the basal concentration of leucine and the removal of metabolic effects of infused L-leucine. 2. The blood concentration of leucine as significantly increased by surgery, starvation and accidental injury, and decreased in cirrhosis. It tended to increase in diabetes and was unaffected by muscular dystrophy. 3. The half-life of infused leucine was nearly doubled by 4 days of complete starvation, unaltered by surgery and decreased by severe accidental injury, Infusion with Intralipid, which increased free fatty acid and ketone-body concentrations, had no effect on the removal of a leucine load. The clearance rate of infused leucine was reduced in diabetes and muscular dystrophy and increased in cirrhosis. 4. The effects of infused leucine on blood glucose and ketone bodies differed according to the groups studied. 5. Since the traumatized patients were given sufficient energy and nitrogen and disposed of a leucine load at a different rate from the starved patients, the causes of the increase in blood concentration of leucine in these two conditions are different. PMID:7428295

Elia, M; Farrell, R; Ilic, V; Smith, R; Williamson, D H

1980-10-01

377

C-Section  

Medline Plus

Full Text Available C-Section Introduction A Cesarean section, or C-section, is the surgical delivery of a baby through ... the baby while recovering from surgery. After a C-Section The hospital stay after a C-section ...

378

Immersion Condensation on Oil-Infused Heterogeneous Surfaces for Enhanced Heat Transfer  

Science.gov (United States)

Enhancing condensation heat transfer is important for broad applications from power generation to water harvesting systems. Significant efforts have focused on easy removal of the condensate, yet the other desired properties of low contact angles and high nucleation densities for high heat transfer performance have been typically neglected. In this work, we demonstrate immersion condensation on oil-infused micro and nanostructured surfaces with heterogeneous coatings, where water droplets nucleate immersed within the oil. The combination of surface energy heterogeneity, reduced oil-water interfacial energy, and surface structuring enabled drastically increased nucleation densities while maintaining easy condensate removal and low contact angles. Accordingly, on oil-infused heterogeneous nanostructured copper oxide surfaces, we demonstrated approximately 100% increase in heat transfer coefficient compared to state-of-the-art dropwise condensation surfaces in the presence of non-condensable gases. This work offers a distinct approach utilizing surface chemistry and structuring together with liquid-infusion for enhanced condensation heat transfer.

Xiao, Rong; Miljkovic, Nenad; Enright, Ryan; Wang, Evelyn N.

2013-06-01

379

Electromagnetic interference to infusion pumps. Update2008 from GSM mobile phones.  

Science.gov (United States)

Electromagnetic interference (EMI) to critical care medical devices has been reported by various groups. Previuos study demonstrated that infusion pumps are susceptible of false alarm buzzing and block of infusion, when exposed to various EMI sources. Aim of this paper is to investigate the changes in the risk of EMI from the estimates of our previous 2005 survey and to extend the EMI risk assessment to newer telecommunication products: DECT phones and WiFi terminals. With regards to GSM phones, compare to the results obtained in 2005, we observed a decrease in the rate of failure (from 58% to 30%). From our findings, the use of WiFi and DECT does not pose a real risk to infusion systems. PMID:19163716

Calcagnini, G; Censi, F; Triventi, M; Mattei, E; Losterzo, R; Marchetta, E; Bartolini, P

2008-01-01

380

Dialysis Access Graft Thrombolysis: Randomized Study of Pulse-Spray Versus Continuous Urokinase Infusion  

International Nuclear Information System (INIS)

Purpose: To compare pulse-spray to continuous-infusion thrombolysis with high-dose urokinase in thrombosed dialysis access grafts. Methods: A prospective randomized controlled trial was performed. From August 1992 to September 1993, 30 thrombosed polytetrafluoroethylene (PTFE) grafts in 24 patients were included, 15 grafts in each group. The success of thrombolysis, mean time to thrombolysis, mean urokinase dose, and 60-day patency rate were evaluated. Results: In the pulse-spray group, the mean time to thrombolysis was 72 min with a mean urokinase dose of 560,000 U. The 60-day patency rate was 71%. In the continuous-infusion group, the mean infusion time to thrombolysis was 55 min with a mean dose of 479,000 U. The 60-day patency rate was 73%. Conclusion: No statistically significant difference was found between the two techniques in the mean time to thrombolysis, the mean urokinase dose used, or the 60-day patency rate

381

PENGARUH INFUS DAUN PLANTAGO MAYOR L (DAUN URAT PADA UTERUS TIKUS YANG DIOVAREKTOMI  

Directory of Open Access Journals (Sweden)

Full Text Available Secara empiris daun Plantigo mayor L (daun urat digunakan untuk obat tidur teratur datang haid. Berdasarkan pemakaian tersebut, diduga daun Plantigo mayor L dapat mempengaruhi sistem reproduksi termasuk organ reproduksi. Oleh karena itu, dilakukan penelitian pengaruh infus daun Plantigo mayor L terhadap uterus pada tikus yang diovarektomi untuk membuktikan adanya pengaruh terhadap organ reproduksi, terutama uterus. Infus diberikan secara oral dengan dosis 7,5mg ; 75mg dan 225mg/100g bobot badan dan sebagai blangko diberikan akuades dengan volume dosis 1 kl/100g bobot badan yang juga diberikan secara oral. Perlakuan diberikan setiap hari selama 7 hari. Hasil penelitian menunjukkan bahwa infus daun Plantigo mayor L dosis 7,5mg/100g bobot badan dapat menghambat atrofi uterus pada tikus yang diovarektomi.

Sa'roni Sa'roni

2012-10-01

382

Treatment of cytomegalovirus retinitis with cytomegalovirus-specific T-lymphocyte infusion.  

Science.gov (United States)

Cytomegalovirus (CMV) retinitis is a potentially blinding infection that affects immunocompromised patients who are unable to generate a T-cell response against the organism. Infusion of CMV-specific leukocytes has been shown to be effective in patients with systemic CMV infection, especially those resistant to standard therapies. The authors report a case of a patient with CMV viremia with progressive retinitis in whom infusion of third-party donor-derived CMV pp65-specific T cells alone prompted resolution of CMV retinitis. This case suggests a potential role for CMV-specific leukocyte infusion in the treatment of CMV retinitis, especially in cases resistant or refractory to antiviral therapies. [Ophthalmic Surg Lasers Imaging Retina. 2015;46:80-82.]. PMID:25559515

Gupta, Mrinali Patel; Coombs, Peter; Prockop, Susan E; Hasan, Aisha A; Doubrovina, Ekatarina; O'Reilly, Richard J; Cohen, Stuart H; Park, Susanna S; Kiss, Szilárd

2015-01-01

383

Fluctuating functions related to quality of life in advanced Parkinson disease: effects of duodenal levodopa infusion  

DEFF Research Database (Denmark)

OBJECTIVE: To assess fluctuations in quality of life (QoL) and motor performance in patients with advanced Parkinson disease (PD) treated with continuous daytime duodenal levodopa/carbidopa infusion or conventional therapy. METHODS: Of 18 patients completing a 6-week trial (DIREQT), 12 were followed for up to 6 months and assessed using electronic diaries and the PD Questionnaire-39 (PDQ-39). RESULTS: During the trial and follow-up, major diurnal fluctuations were observed, especially for hyperkinesia, 'off' time, ability to walk and depression. Duodenal infusion was associated with significantly more favourable outcomes compared with conventional treatment for satisfaction with overall functioning, 'off' time and ability to walk, with improved outcomes with PDQ-39. CONCLUSIONS: Relative to conventional treatment, infusion therapy may stabilize and significantly improve motor function and patient's QoL. The potential for daily fluctuation in PD symptoms means single measures of treatment effectiveness can result in bias in effect estimates and hence repeated measures are recommended.

Isacson, D; Bingefors, K

2008-01-01

384

Model Predictive Control of Drug Infusion System for Mean Arterial Pressure Regulation of Critical Care Patients  

Directory of Open Access Journals (Sweden)

Full Text Available Patients recovering in critical care units are continuously monitored for their hemodynamic states and accordingly given proper medication. The widely monitored hemodynamic variable is the Mean Arterial Pressure (MAP, which is regulated by infusion of vasoactive drugs like Sodium Nitroprusside (SNP. Presently, physicians check the patients’ MAP at regular intervals. This task is time-consuming and if automated, allows the physicians to attend to other critical parameters, which cannot be measured. Automation of the drug infusion based on the MAP would lead to continuous regulation of the hemodynamic variable enabling speedier recovery. This study attempts to automate the regulation of the drug infusion system using a model predictive controller. The controller’s performance was tested for three types of patient models. The controller tracks the set point changes and maintains the mean arterial pressure within the required values.

S.A. Nirmala

2014-05-01

385

[Residual pesticide concentrations after processing various types of tea and tea infusions].  

Science.gov (United States)

The effects of processing to produce various types of tea or infusion on the levels of pesticide residues in tea were investigated for three insecticides (chlorfenapyr, pyrimiphos-methyl, and clothianidin). Tea plants were sprayed with one of the three pesticides and cultivated under cover. The levels of pesticide residues in tea decreased after processing according to the time and temperature of heating, as well as fermentation. Although significant differences were not observed among the three pesticides in the ratio of decreased of pesticide concentration after processing to green tea, clothianidin, which is a neonicotinoid insecticide and has a lower log Pow value, tended to be transferred more than the other two insecticides into infusions. However, no significant difference in the ratios of clothianidin transferred to infusions was observed among green tea with three different leaf sizes. PMID:24025203

Kondo, Takahide; Watanabe, Ayaka; Shitara, Hiroshi; Kaburagi, Yasuo; Shibata, Masahisa; Kanda, Noriko; Kurokawa, Chieko; Inoue, Yutaka; Miyazaki, Motonobu; Togawa, Masayuki; Ozawa, Akihito; Uchiyama, Toru; Koizumi, Yutaka; Nakamura, Yoriyuki; Masuda, Shuichi; Maitani, Tamio

2013-01-01

386

Decoction, infusion and hydroalcoholic extract of cultivated thyme: antioxidant and antibacterial activities, and phenolic characterisation.  

Science.gov (United States)

Bioactivity of thyme has been described, but mostly related to its essential oils, while studies with aqueous extracts are scarce. Herein, the antioxidant and antibacterial properties of decoction, infusion and hydroalcoholic extract, as also their phenolic compounds, were evaluated and compared. Decoction showed the highest concentration of phenolic compounds (either phenolic acids or flavonoids), followed by infusion and hydroalcoholic extract. In general, the samples were effective against gram-positive (Staphylococcus aureus and Staphylococcus epidermidis) and gram-negative (Escherichia coli, Klebsiella spp., Pseudomonas aeruginosa, Enterococcus aerogenes, Proteus vulgaris and Enterobacter sakazakii) bacteria, with decoction presenting the most pronounced effect. This sample also displayed the highest radical scavenging activity and reducing power. Data obtained support the idea that compounds with strong antioxidant and antibacterial activities are also water-soluble. Furthermore, the use of thyme infusion and decoction, by both internal and external use, at recommended doses, is safe and no adverse reactions have been described. PMID:25148969

Martins, Natália; Barros, Lillian; Santos-Buelga, Celestino; Silva, Sónia; Henriques, Mariana; Ferreira, Isabel C F R

2015-01-15

387

Selective intra arterial infusion chemotherapy for malignant nasal and paranasal sinus tumors  

Energy Technology Data Exchange (ETDEWEB)

Since 1998, we have treated 14 malignant nasal and paranasal sinus tumor patients with selective intra arterial infusion chemotherapy. We report results for 7 of maxillary sinus, 3 of sphenoid sinus 1 of ethmoid sinus, and 3 of the nasal cavity. Only 1 maxillary sinus case involved recurrence. Intra arterial infusions of cisplatin (100 mg/body) was delivered rapidly to the tumor and usually repeated for 4 times. Conventional external-beam irradiation (2 Gy per fraction x 30) was also used. Complete response cases were 9 of 14 and control of the local lesion found in all new cases. These results indicate that intra arterial infusion therapy is effective against advanced malignant nasal and paranasal sinus tumors. (author)

Miyajima, Yoshimi; Nakashima, Tadashi; Hayabuchi, Naofumi; Abe, Toushi; Tanaka, Norimitsu [Kurume Univ., Fukuoka (Japan). School of Medicine

2003-04-01

388

Superselective cerebral arterial infusion of BCNU in high-grade glioma: The radiologist's point of view  

International Nuclear Information System (INIS)

Twenty-seven patients with high-grade glioma were candidates for superselective cerebral infusion of BCNU after surgery and radiation therapy. A total of 59 catheterizations were undertaken using an 8-F guiding catheter through which a 2.5 F balloon catheter was propelled into the main arterial trunk feeding the tumor. Ten procedures were stopped because of arterial spasm with transient deficit or prolonged catheterization time. Forty-nine infusions of 150-200 mg of BCNU were carried out, each lasting 3 hours. In 75% of patients, stabilization or improvement was noted on CT scan 5 weeks after treatment. This study demonstrates the safety of supraophthalmic catheterization, the feasibility of prolonged catheterization, and the relative effectiveness of low-dose BCNU infused over a long period of time

389

Antimutagenic Activity and Radical Scavenging Activity of Water Infusions and Phenolics from Ligustrum Plants Leaves  

Directory of Open Access Journals (Sweden)

Full Text Available Water infusions of Ligustrum delavayanum and Ligustrum vulgare leaves and eight phenolics isolated therefrom have been assayed in vitro on ofloxacin-induced genotoxicity in the unicellular flagellate Euglena gracilis. The tested compounds luteolin, quercetin, luteolin-7-glucoside, luteolin-7-rutinoside, quercetin-3-rutinoside, apigenin-7-rutinoside, tyrosol and esculetin inhibited the mutagenic activity of ofloxacin (43 µM in E. gracilis. Water infusions from leaves of L. delavayanum and L. vulgare showed higher antimutagenic effect (pt < 0.001. The activity of these samples against ofloxacin (86 µM-induced genotoxicity was lower, but statistically significant (pt < 0.05, excluding the water infusion of L. delavayanum leaves (pt < 0.01. Efficacy of quercetin, luteolin-7-rutinoside, apigenin-7-rutinoside was insignificant. The antimutagenic effect of most phenolics we studied could be clearly ascribed to their DPPH scavenging activity, substitution patterns and lipophilicity.

Milan Nagy

2009-01-01

390

Transarterial infusion chemotherapy with a combination of gemcitabine and 5-fluorouracil in advanced pancreatic carcinoma  

International Nuclear Information System (INIS)

Objective: To retrospectively analyze the effectiveness of transarterial infusion chemotherapy of gemcitabine and 5-fluorouracil in advanced pancreatic carcinoma. Methods: Twenty-two patients with advanced pancreatic carcinoma were treated with transarterial infusion chemotherapy. Gemcitabine and 5-fluorouracil was administered to the patients via an interarterial catheter. Then the tumor response rate and clinical benefit were observed. Results: A clinical benefit was obtained in 8 patients (36.4%). The tumor response rate was 13.6%. Median survival for all the patients was 6.1 months. Median time to tumor progression was 2.9 months. Conclusion: Transarterial infusion chemotherapy with a combination of gemcitabine and 5-fluorouracil appears to have good clinical benefit and may prolong the survival time of patients with advanced pancreatic carcinoma

391

Infusion of hypertonic saline before elective hysterectomy: effects on cytokines and stress hormones.  

DEFF Research Database (Denmark)

BACKGROUND: Infusion of hypertonic saline provides early haemodynamic benefits and may affect the immune system. It is unknown if infusion of hypertonic saline affects plasma cytokines and stress hormones after surgery. METHODS: Sixty-two women undergoing abdominal hysterectomy were randomized in a double-blind study to infusion of NaCl 7.5% (HS), NaCl 0.9% (NS4), both 4 ml kg(-1), or NaCl 0.9% 32 ml kg(-1) (NS32) over 20 min. Blood was collected at baseline, 1, 4, and 24 h after surgery (n=34) for the determination of interleukin (IL)-1beta, IL-6, IL-8, IL-10, IL-12, IL-1ra, and tumour necrosis factor-alpha. Serum cortisol and vasopressin were measured at these time points and 48 h after operation. Epinephrine and norepinephrine (n=26) were quantified at baseline, after infusion, 25 min after incision, 1, and 4 h after surgery. Finally, C-reactive protein was measured at baseline, 24, and 48 h after surgery. RESULTS: Surgery and anaesthesia induced well-reported changes in the concentrations of cytokines andhormones. The concentration of norepinephrine briefly increased after infusion of HS and NS32 but not NS4 (P<0.05). Epinephrine was increased 25 min after incision in Group NS32 compared with the other groups (P<0.05). No other differences were found between the groups. CONCLUSIONS: Infusion of a clinically relevant dose of hypertonic saline before hysterectomy appears to have limited effect on the postoperative concentration of selected plasma cytokines and the hormonal stress-response. Udgivelsesdato: 2008-Apr

KØlsen-Petersen, Jens Aage; Bendtzen, Klaus

2008-01-01

392

Severe infusion reactions to infliximab: aetiology, immunogenicity and risk factors in patients with inflammatory bowel disease  

DEFF Research Database (Denmark)

BACKGROUND: Infliximab (IFX) elicits acute severe infusion reactions in about 5% of patients with inflammatory bowel disease (IBD). AIM: To investigate the role of anti-IFX antibodies (Ab) and other risk factors. METHODS: The study included all IBD patients treated with IFX at a Danish university hospital until 2010 either continuously (IFX every 4-12 weeks) or episodically (reinitiation after >12 weeks). Anti-IFX Ab were measured using radioimmunoassay. RESULTS: Twenty-five (8%) of 315 patients experienced acute severe infusion reactions. Univariate analysis showed that patients who reacted were younger at the time of diagnosis (19 vs. 26 years, P=0.013) and at first IFX infusion (28 vs. 35 years, P=0.012). Furthermore, they more often received episodic therapy (72% vs. 31%, P<0.001) and logistic regression revealed this as the only significant predictor of reactions (OR 5 [2-13]; P<0.001). IFX reinitiation after 6 months intermission further increased the risk (OR 8 [3-20], P<0.001). Most reactions (n=14, 88%) occurred at 2nd infusion in the 2nd treatment series (P=0.006). Anti-IFX IgG Ab were highly positive in 19 of 20 patients (95%) shortly after the reactions (median 84 U/mL). Anti-IFX IgG Ab measured prior to the retreatment series were negative in 7 of 11 patients tested (64%). Anti-IFX IgE Ab were negative in all patients with reactions. CONCLUSIONS: Acute severe infusion reactions were strongly associated with development of anti-IFX IgG Ab, but not with anti-IFX IgE Ab. The risk was particularly high at the 2nd infusion in retreatment series. Negative anti-IFX Ab before reinitiation did not rule out reactions.

Steenholdt, Casper; Svenson, M

2011-01-01

393

Exercise-mediated vasodilation in human obesity and metabolic syndrome: effect of acute ascorbic acid infusion.  

Science.gov (United States)

We tested the hypothesis that infusion of ascorbic acid (AA), a potent antioxidant, would alter vasodilator responses to exercise in human obesity and metabolic syndrome (MetSyn). Forearm blood flow (FBF, Doppler ultrasound) was measured in lean, obese, and MetSyn adults (n = 39, 32 ± 2 yr). A brachial artery catheter was inserted for blood pressure monitoring and local infusion of AA. FBF was measured during dynamic handgrip exercise (15% maximal effort) with and without AA infusion. To account for group differences in blood pressure and forearm size, and to assess vasodilation, forearm vascular conductance (FVC = FBF/mean arterial blood pressure/lean forearm mass) was calculated. We examined the time to achieve steady-state FVC (mean response time, MRT) and the rise in FVC from rest to steady-state exercise (?, exercise - rest) before and during acute AA infusion. The MRT (P = 0.26) and steady-state vasodilator responses to exercise (?FVC, P = 0.31) were not different between groups. Intra-arterial infusion of AA resulted in a significant increase in plasma total antioxidant capacity (174 ± 37%). AA infusion did not alter MRT or steady-state FVC in any group (P = 0.90 and P = 0.85, respectively). Interestingly, higher levels of C-reactive protein predicted longer MRT (r = 0.52, P exercise does not alter the time course or magnitude of exercise-mediated vasodilation in groups of young lean, obese, or MetSyn adults. However, systemic inflammation may limit the MRT to exercise, which can be improved with AA. PMID:25038148

Limberg, Jacqueline K; Kellawan, J Mikhail; Harrell, John W; Johansson, Rebecca E; Eldridge, Marlowe W; Proctor, Lester T; Sebranek, Joshua J; Schrage, William G

2014-09-15

394

Abnormal renal vasodilation to an amino acid infusion in congestive heart failure: normalization by enalapril.  

Science.gov (United States)

In congestive heart failure (CHF), the neurohormonal mechanisms that cause renal vasoconstriction, particularly those depending on the renin-angiotensin system, could interfere with renal vasodilating mechanisms. To elucidate this issue, we studied the kidney response to an amino acid infusion (known to cause renal vasodilation in healthy individuals) in eight patients with CHF. We found that the amino acid infusion (0.7 mL/kg/h of a 10% solution) elicited no renal hemodynamic response, in marked contrast to healthy subjects. We next hypothesized that the renin-angiotensin system (known to be activated in heart failure) has a role in the lack of response to the amino acid infusion. To test this hypothesis, we repeated the study after two 5-mg doses of enalapril, an inhibitor of the angiotensin-converting enzyme, administered 12 hours apart. After enalapril treatment, the amino acid infusion caused a 45% increase in mean renal blood flow (RBF) from 383 +/- 55 to 557 +/- 51 mL/min at the fifth hour (P renal response to the amino acid infusion occurred without changes in cardiac output or in systemic vascular resistance. Hence, the renal fraction of the cardiac output increased during the amino acid infusion. The recovery of the renal vascular response was not accompanied by an increase in glomerular filtration rate (GFR; filtration fraction decreased), suggesting a predominant efferent arteriole dilatation. Our study shows that, in heart failure, the kidney loses its ability to increase RBF in response to an amino acid load. This lack of renal vascular response can be restored by inhibiting the renin-angiotensin system and is unrelated to changes in systemic hemodynamics. PMID:9915266

Juncos, L I; Juncos, L A; Ferrer, M C; Sampaolessi, A H; Romero, J C

1999-01-01

395

Airway hyperresponsiveness induced by repeated esophageal infusion of HCl in guinea pigs.  

Science.gov (United States)

Gastroesophageal reflux is a common disorder closely related to chronic airway diseases, such as chronic cough, asthma, chronic bronchitis, and chronic obstructive disease. Indeed, gastroesophageal acid reflux into the respiratory tract causes bronchoconstriction, but the underlying mechanisms have still not been clarified. This study aimed to elucidate functional changes of bronchial smooth muscles (BSMs) isolated from guinea pigs in an animal model of gastroesophageal reflux. The marked airway inflammation, hyperresponsiveness and remodeling were observed after guinea pigs were exposed to intraesophageal HCl infusion for 14 days. In addition, contractile responses to acetylcholine (ACh), KCl, electrical field stimulation, and extracellular Ca(2+) were greater in guinea pigs infused with HCl compared with control groups. The L-type voltage-dependent Ca(2+) channels (L-VDCC) blocker, nicardipine, significantly inhibited ACh- and Ca(2+)-enhanced BSM contractions in guinea pigs infused with HCl. The Rho-kinase inhibitor, Y27632, attenuated ACh-enhanced BSM contractions in guinea pigs infused with HCl. Moreover, mRNA and protein expressions for muscarinic M2 and M3 receptors, RhoA, and L-VDCC in BSM were detected by real-time PCR and Western blot. Expressions of mRNA and protein for muscarinic M3 receptors, RhoA, and L-VDCC were greater than in BSM of HCl-infused guinea pigs, whereas levels of muscarinic M2 receptors were unchanged. We demonstrate that acid infusion to the lower esophagus and, subsequently, microaspiration into the respiratory tract in guinea pigs leads to airway hyperresponsiveness and overactive BSM. Functional and molecular results indicate that overactive BSM is the reason for enhancement of extracellular Ca(2+) influx via L-VDCC and Ca(2+) sensitization through Rho-kinase signaling. PMID:24828018

Cheng, Yan-Mei; Cao, Ai-Li; Zheng, Jian-Pu; Wang, Hong-Wei; Sun, Yong-Shun; Liu, Chun-Fang; Zhang, Bei-Bei; Wang, Yi; Zhu, Sheng-Liang; Wu, Da-Zheng

2014-11-01

396

CT enhancement of acute cerebral infarction following long-term continuous contrast infusion  

International Nuclear Information System (INIS)

In this experimental study, we employed a long-term (3 hours) continuous-drip infusion of the contrast medium (200 ml of meglumine amidtrizoate) rather than the conventional bolus injection. On admission, four-vessel angiography was performed on all 14 patients. Within 3 days after the onset of the disease, CT scan was carried out repeatedly just prior to contrast infusion, immediately after the end of the continuous-contrast infusion, and additionally, in 4 cases, 3 hours after the end of the contrast infusion. The Haunsfield number was calculated in 3 regions of interest (Radius 5) in the infarction. Positive enhancement was observed in 10 out of the 14 patients (71 %). Among them, 4 out of 5 patients in whom no vascular obstraction on angiography, but marked low-density areas with a mass effect on CT were observed, showed moderate to marked enhancement. In these 4 patients, a temporary cerebral ischemia due to vascular embolization was considered. From the other 4 patients in whom the additional CT scan was performed 3 hours after the end of the contrast infusion, a blood sample was obtained at each of the 3 CT scannings. The iodine concentrations of the blood samples were measured, and their Haunsfield numbers were calculated in the water phantom. The above two parameters were well correlated in a linear function. Among the 4 patients, Gado's tissue-blood ratio (the Haunsfield number of the CT lesion is divided by that of the blood sample) was more than 17.2 % immthe blood sample) was more than 17.2 % immediately after, and more than 54.7 % 3 hours after, the contrast infusion. Thus, we could conclude that the break-down of the BBB which was demonstrated by a long-term high-blood-concentration level of the contrast medium is an earlier event in human cerebral infarction than is usually accepted. The findings are compatible with our results in animal experiments. (author)

397

Tracer measured substrate turnover requires arterial sampling downstream of infusion site  

International Nuclear Information System (INIS)

Measurement of metabolite turnover (Rt) with radioactive tracers is done by either infusing tracer venously and sampling specific activity (SA) arterially (V-A modes), or by infusing into the aorta and sampling venous blood (A-V mode). Using the Fick principle, the necessity for using the V-A mode can be demonstrated. If tracer is infused into the left ventricle, in a steady state the Rt is the product of arterial trace concentration, the cardiac output, and the tracer extraction ratio for the whole body. This is expressed as: Rt = Ca x Qx ((*Ca - *Cv)/*Ca) (Eq1) where C=trace concentration (?mol/ml), *C=tracer conc. (dpm/ml), a=arterial, v-=mixed venous, and Q=cardiac output (ml/min). Rearranging the equation: Rt = Qx(*Ca - *Cv)/SAa = F/SAa (Eq2) where SAa is *Ca/Ca, and Qx (*Ca-*Cv) equals the infusion rate (F). The authors compared Eqs1 and 2 (Rt = F/SAa) in 3 anesthetized dogs in which [1-14C] lactate was infused into the left ventricle, and blood was sampled arterially downstream from the infusion site and in the pulmonary artery. Eqs 1 and 2 gave similar results for Rt (45.9 vs. 43.9 ?mol/kg min), while substituting SAv for SAa (A-V mode) into Eq 2 gave a higher Rt (53.6). When SAv (A-V mode) is used, the specific activity seen by the tissues (SAa) is not considered in the calculation of Rt. Therefore, only the V-A mode meets the requirements for tracer measured metabolite turnover

398

Characterization of peptide-YY release in response to intracolonic infusion of amino acids.  

Science.gov (United States)

Peptide-YY-(1-36) [PYY-(1-36)] is an endocrine peptide that is found primarily in the mucosal layer of the colon. We reported previously that a direct intracolonic (IC) infusion of amino acids in dogs resulted in a robust release of PYY compared to other nutrients (fat, glucose, and protein). The objective of this study was to investigate the possible mechanisms underlying the release of PYY in response to IC infusion of amino acids. Intracolonic infusion of a mixture of tryptophan and phenylalanine (Trp+Phe; 100 mM; 200 ml/h) resulted in a significant release of PYY [integrated PYY release, 74.5 +/- 14.0 ng (0-120 min)/ml], which was not affected by iv atropine, hexamethonium, or propranolol treatment. Intravenous infusion of Trp+Phe failed to release PYY [integrated PYY release, -0.6 +/- 0.9 ng (0-120 min)/ml]. Intracolonic infusion of aromatic amino acids (Trp+Phe) was more potent in releasing PYY than aliphatic (leucine and glycine) and charged (arginine) amino acids. PYY release in response to IC infusion of the deamino and decarboxylated forms of Phe was significantly (P contact of amino acids with the luminal pole of PYY cells in the colon and is not the result of a stimulatory action of amino acids via the general circulation; and 3) the amino and carboxylic groups of an amino acid as well as the ring structures of aromatic amino acids are structural requirements for PYY release. PMID:8093875

Zhang, T; Brubaker, P L; Thompson, J C; Greeley, G H

1993-02-01

399

Natriuretic peptide infusion reduces myocardial injury during acute ischemia/reperfusion  

DEFF Research Database (Denmark)

Aim: The aim of this study was to determine whether a natriuretic peptide infusion during reperfusion can reduce cardiomyocyte ischemia–reperfusion damage. Materials and methods: The effect of B-type natriuretic peptide (BNP) activity was assessed in vitro and in vivo: the cellular effect was determined by assessment of intracellular caspase activity and troponin T release from cultured HL-1 cells subjected to short-term hypoxia–reperfusion. Cardiac effects were further examined in pigs (n=25) that had been subjected to 1 h of regional cardiac ischemia, followed by 3 h of reperfusion. Results: HL-1 cardiomyocytes responded to exogenous BNP with increased cGMP activity (?3-fold, P=0.0037) and hypoxia–reperfusion with increased vascular endothelial growth factor and BNPmRNA contents (2.3- and 2.5-fold, respectively, P<0.0001) and caspase activity (2.9-fold, P=0.03), but without a decrease in apoptotic changes in the BNP-stimulated cells. Pigs tolerated the BNP and CD-NP (a CNP analogue) infusion well,with a decrease in systemic blood pressure (?15 mmHg) and increased diuresis compared with the controls. Left ventricular pressure decreased in the pigs that received BNP infusion compared with controls (P=0.02). A similar trend was observed in the pigs that received CD-NP infusion, although this was not significant (P=0.3). BNP and CD-NP infusion in pigs reduced total cardiac troponin T release by 46 and 40%, respectively (P=0.0015 and 0.0019), and were associated with improved RNA integrity in the ischemic left ventricular region (P<0.05). Conclusion: We report that natriuretic peptide infusion in vivo reduces cardiomyocyte injury in acute ischemia–reperfusion, possibly through indirect mechanisms (e.g. increased diuresis and vasodilation). The results suggest a role for natriuretic peptide therapy in human cardiac ischemia.

Kousholt, Birgitte S.; Larsen, Jens Kjærgaard Rolighed

2012-01-01

400

In vivo tracking of 111In-oxine labeled mesenchymal stem cells following infusion in patients with advanced cirrhosis  

International Nuclear Information System (INIS)

Background: Several animal and few human studies suggest the beneficial role of bone marrow mesenchymal stem cells (MSCs) in liver cirrhosis. However, little is known about the fate of MSCs after infusion in cirrhotic patients. We evaluated stem cell biodistribution after peripheral infusion of MSCs in four cirrhotic patients. Methods: After three passages of MSCs, the patients received a total of 250-400x106 cells, of which only 50% of the cells were labeled. Specific activities of 0.21-0.67 MBq/106 cells were maintained for the injected labeled MSCs. Planar whole-body acquisitions (anterior/posterior projections) were acquired immediately following infusion as well as at 2 h, 4 h, 6 h, 24 h, 48 h, 7th and 10th days after cell infusion. Results: After intravenous infusion, the radioactivity was first observed to accumulate in the lungs. During the following hours to days, the radioactivity gradually increased in the liver and spleen, with spleen uptake exceeding that in the liver in all patients. Region-of-interest analysis showed that the percentage of cells homing to the liver (following decay and background corrections and geometric mean calculation) increased from 0.0%-2.8% at immediately post-infusion images to 13.0-17.4% in 10th-day post-infusion. Similarly, the residual activities in the spleen increased from 2.0%-10.2% at immediately post-infusion images to 30.1%-42.2% in 10th-day post-infusion. During the same period, the residual activDuring the same period, the residual activities in the lungs decreased from 27.0-33.5% to 2.0-5.4%. Conclusion: The infusion of MSCs labeled with 111In-oxine through a peripheral vein is safe in cirrhosis. Cell labeling with 111In-oxine is a suitable method for tracking MSC distribution after infusion.

401

In vivo tracking of {sup 111}In-oxine labeled mesenchymal stem cells following infusion in patients with advanced cirrhosis  

Energy Technology Data Exchange (ETDEWEB)

Background: Several animal and few human studies suggest the beneficial role of bone marrow mesenchymal stem cells (MSCs) in liver cirrhosis. However, little is known about the fate of MSCs after infusion in cirrhotic patients. We evaluated stem cell biodistribution after peripheral infusion of MSCs in four cirrhotic patients. Methods: After three passages of MSCs, the patients received a total of 250-400x10{sup 6} cells, of which only 50% of the cells were labeled. Specific activities of 0.21-0.67 MBq/10{sup 6} cells were maintained for the injected labeled MSCs. Planar whole-body acquisitions (anterior/posterior projections) were acquired immediately following infusion as well as at 2 h, 4 h, 6 h, 24 h, 48 h, 7th and 10th days after cell infusion. Results: After intravenous infusion, the radioactivity was first observed to accumulate in the lungs. During the following hours to days, the radioactivity gradually increased in the liver and spleen, with spleen uptake exceeding that in the liver in all patients. Region-of-interest analysis showed that the percentage of cells homing to the liver (following decay and background corrections and geometric mean calculation) increased from 0.0%-2.8% at immediately post-infusion images to 13.0-17.4% in 10th-day post-infusion. Similarly, the residual activities in the spleen increased from 2.0%-10.2% at immediately post-infusion images to 30.1%-42.2% in 10th-day post-infusion. During the same period, the residual activities in the lungs decreased from 27.0-33.5% to 2.0-5.4%. Conclusion: The infusion of MSCs labeled with {sup 111}In-oxine through a peripheral vein is safe in cirrhosis. Cell labeling with {sup 111}In-oxine is a suitable method for tracking MSC distribution after infusion.

Gholamrezanezhad, Ali, E-mail: agholam1@jhmi.edu [Research Institute for Nuclear Medicine. Shariati Hospital. Tehran University of Medical Sciences, Tehran, 14114 (Iran, Islamic Republic of); Mirpour, Sahar [Research Institute for Nuclear Medicine. Shariati Hospital. Tehran University of Medical Sciences, Tehran, 14114 (Iran, Islamic Republic of); Bagheri, Mohammad; Mohamadnejad, Mehdi [Digestive Disease Research Center. Shariati Hospital. Tehran University of Medical Sciences, Tehran, 14114 (Iran, Islamic Republic of); Alimoghaddam, Kamran [Hematology and BMT Research Center. Shariati Hospital. Tehran University of Medical Sciences, Tehran, 14114 (Iran, Islamic Republic of); Abdolahzadeh, Leila [Digestive Disease Research Center. Shariati Hospital. Tehran University of Medical Sciences, Tehran, 14114 (Iran, Islamic Republic of); Saghari, Mohsen [Research Institute for Nuclear Medicine. Shariati Hospital. Tehran University of Medical Sciences, Tehran, 14114 (Iran, Islamic Republic of); Malekzadeh, Reza [Digestive Disease Research Center. Shariati Hospital. Tehran University of Medical Sciences, Tehran, 14114 (Iran, Islamic Republic of)

2011-10-15

402

Effect of Calendula officinalis infusion on indomethacin-induced gastric lesions in Wistar rats. Effecto de la infusion de Calendula officinalis sobre las lesions gástricas provocadas por indometacina  

OpenAIRE

Calendula officinalis is a phytopharmaceutical believed to inhibit gastric emptying and to have hypoglycemic and gastroprotective effects. We aimed to study the putative effect of an infusion of Calendula officinalis on indomethacin-induced gastric lesions. 30 adult male Wistar rats, divided in 2 groups, received indomethacin 20 mg/kg through gavage. Group A (Study) further received 1 mL of 10 % doses of Calendula officinalis, and group B (Control) received saline, for 2 days. After this peri...

Luiz Carlos Bertges; Ângela Maria Gonçalves Felga; João Batista Piccinini Teixeira; Carolina Frade Magalhães Girardin Pimentel; Priscilla Ornella Neves

2006-01-01

403

Detection of reversible myocardial ischemia with MR imaging during dobutamine infusion  

International Nuclear Information System (INIS)

This paper shows that MR imaging detects reversible wall motion abnormalities in 67% of patients with coronary artery disease (CAD) and reversible thallium perfusion defects during dipyridamole stress. This study examines the feasibility and diagnostic value of MR imaging during infusion of dobutamine, an alternative stressor with easily controlled level and duration of stress. Patients undergoing coronary angiography were studied with cine MR imaging of ventricular wall motion in two long and two short axes, and with dobutamine thallium tomography. Baseline and peak stress images were acquired. Dobutamine was infused in four stages from 5--20 ?g/kg/min until maximum dose or symptoms occurred

404

Effect of abomasal glucose infusion on splanchnic amino acid metabolism in periparturient dairy cows  

DEFF Research Database (Denmark)

Six Holstein cows fitted with ruminal cannulas and permanent indwelling catheters in the portal vein, hepatic vein, mesenteric vein, and an artery were used to study the effects of abomasal glucose infusion on splanchnic AA metabolism. The experimental design was a split plot, with cow as the whole plot, treatment as the whole-plot factor and days in milk (DIM) as the subplot factor. Cows were assigned to 1 of 2 treatments: control or infusion of 1,500 g/d of glucose into the abomasum from the day of calving to 29 DIM.

Larsen, Mogens; Kristensen, Niels Bastian

2009-01-01

405

Failure of Vancomycin Continuous Infusion against Experimental Endocarditis Due to Vancomycin-Intermediate Staphylococcus aureus ?  

OpenAIRE

Continuous infusion of vancomycin was evaluated against experimental endocarditis due to heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) and VISA. Animals were infected with hVISA PC1 (vancomycin MIC, 2 mg/liter) or VISA PC3 (vancomycin MIC, 8 mg/liter) and treated for 5 days with constant serum levels of 20 or 40 mg/liter. Vancomycin continuous infusion was unsuccessful, as 20 mg/liter was barely active against PC1 (6 of 13 sterile vegetations) and 40 mg/liter failed agai...

Entenza, J. M.; Veloso, T. R.; Vouillamoz, J.; Giddey, M.; Moreillon, P.

2011-01-01

406

Blood bank leukocyte infusions as remission induction therapy in a case of acute lymphoblastic leukemia.  

Science.gov (United States)

A 15-year-old female with pre-pre B ALL in third relapse was treated with administration of eight blood bank leukocyte concentrates per day for 5 days. The total number of mononuclear cells per kilogram of weight was 4.89 x 10(8). On the fifth day of infusions the patient was in complete remission (CR), asymptomatic and with a normal CBC. No secondary effects were found. The patient remained in CR without treatment for 10 weeks before relapsing again. The possibility of reaching a short-lived, clinically relevant response, using blood bank leukocyte infusions, is a promising new approach for the treatment of leukemia. PMID:9383238

Borbolla, J R; López, M A; Alvarado, M; Guzman, L; DeDiego, J; Trueba, E; González, M; Anaya, I

1997-10-01

407

15O-water constant infusion system for clinical routine application  

International Nuclear Information System (INIS)

For measurements of extravascular water in the lungs, we have set up a constant infusion system for 15O-water. 15O is produced by 8 MeV deuteron bombardment of nitrogen containing 0.2% oxygen. About 20m from the target, the molecular oxygen passes a control station for calibration, purification and analysis and is then led on for about 30m to the 15O-water production and infusion system right besides the PET imaging device. The system has been used in clinical routine studies on more than 200 patients during the past 3 years without adverse effects in any case. (author)

408

Effects of an EDTA infusion on the urinary elimination of several elements in healthy subjects.  

OpenAIRE

Ethylene diamine tetraacetate calcium disodium salt (EDTA Ca Na2), 1 g dissolved in 250 ml of 5% w/v glucose solution, was infused intravenously over 1 h into 10 healthy subjects (eight males and two females). Urines were collected over 24 h, the day before and on the day of the EDTA Ca Na2 infusion test. The elements Al, B, Ba, Cu, Fe, Mn, Si, Sr, Zn, Na, K, Ca, Mg, S and P were measured by inductively coupled plasma optical emission spectrometry. Pb was measured by inductively coupled plasm...

Allain, P.; Mauras, Y.; Premel-cabic, A.; Islam, S.; Herve, J. P.; Cledes, J.

1991-01-01

409

Intra-arterial Infusion of Leptin does not Affect Blood Pressure in Salt-loaded Rabbits  

OpenAIRE

The aim of this research is to see the effect of intra-arterial infusion of leptin on blood pressure of salt loaded rabbits in vivo. Increased blood pressure was produced in rabbits by giving diets containing 8% sodium chloride for 5 weeks. Leptin in different concentrations was infused intra-arterially into rabbits fed on high salt diets and the response was compared in rabbits fed with low salt diets. High salt diets produced significant increase in blood pressure. In rabbits fed wit...

Mohammad Nidal Khabaz; Mohamad, Mohamad M. J.; Khalid Talafih; Mohammad, Mukhallad A.

2010-01-01

410

The pharmacokinetics of ifosfamide given as short and long intravenous infusions in cancer patients.  

OpenAIRE

1. We investigated the pharmacokinetics of ifosfamide 5 g m-2 given by two regimens. Six patients (one female), median age 55 (range 40-71) years, all with lung cancer received 5 g m-2 ifosfamide (median ifosfamide dose 8.95 g) as an intravenous infusion over 0.5 h with mesna. Four other cancer patients (all male) of median age 52.5 (range 23-72) years were studied on seven treatment occasions with 5 g m-2 ifosfamide (median ifosfamide dose 8.88 g) as a 24 h intravenous infusion with mesna. P...

Lewis, L. D.; Fitzgerald, D. L.; Mohan, P.; Thatcher, N.; Harper, P. G.; Rogers, H. J.

1991-01-01

411

Promoting Active Learning in Technology-Infused TILE Classrooms at the University of Iowa  

Directory of Open Access Journals (Sweden)

Full Text Available In this case study, the authors describe the successful implementation of technology-infused TILE classrooms at the University of Iowa. A successful collaboration among campus units devoted to instructional technologies and teacher development, the TILE Initiative has provided instructors with a new set of tools to support active learning. The authors detail the implementation of the TILE classrooms, the process of training instructors to design effective instruction for these classrooms, and an assessment project that helps improve the process of ensuring faculty can successfully facilitate learning activities in a technology-infused learning environment.

Sam Van Horne

2012-06-01

412

The new treatment of hepatocellular carcinoma; Hepatic arterial infusion of sup 131 I-Lipiodol  

Energy Technology Data Exchange (ETDEWEB)

We performed intrahepatic arterial infusion of {sup 131}I-labelled Lipiodol ({sup 131}I-Lipiodol) as an internal radiation therapy in twenty patients with hepatocellular carcinoma (HCC). Tumor sizes were reduced in all attempted patients, and serum AFP levels were also decreased in the patients with high levels of serum AFP. Furthermore, the resected specimens of the tumors revealed complete or nearly complete necrosis in 2 patients who were underwent the surgical resection after the treatment. No significant side effects were observed in all attempted patients. These results suggest that intrahepatic arterial infusion of {sup 131}I-Lipiodol is a safe and effective therapeutic method for HCC. (author).

Nagataki, Shigenobu; Johya, Kouichi (Nagasaki Univ. (Japan). School of Medicine)

1989-03-01

413

Analysis of cervical cancer cells treated with radiotherapy or arterial infusion chemotherapy  

Energy Technology Data Exchange (ETDEWEB)

The present study was designed to analyze cervical cancer cells treated with radiotherapy or intraarterial infusion of CDDP using image analysis. Total nuclear extinction (TE), 5 N-exceeding rate (5 NER) and nuclear area (NA) gradually increased following irradiation, in cervical cancer cases. TE and 5 NER increased markedly following radiotherapy in good response cases. TE, 5 NER and NA were not-changed following irradiation in poor response cases. 5 NER, in good prognostic cases was higher than in poor prognostic cases, significantly among cervical cancer cases treated with radiotherapy. 5 NER and NA increased dramatically in good response cases treated with intraarterial infusion of CDDP. (author).

Izutu, Toshihiko; Nishiya, Iwao [Iwate Medical Univ., Morioka (Japan). School of Medicine

1995-07-01

414

Evaluation of lipiodol infusion-CT for the diagnosis of hepatobiliary tumor  

International Nuclear Information System (INIS)

Lipiodol infusion-CT(Lip-CT) performed in 42 patients with hepatobiliary tumor was evaluated. Lip-CT made it possible to identify the margin and structure of main tumor. In the detection of small intrahepatic metastases, Lip-CT was more useful than infusion hepatic arteriography(IHA), balloon occluded hepatic arteriography (BOHA) and contrast enhancement-CT(CE-CT). Therefore, it was considered that Lip-CT was useful for the diagnosis of hepatobiliary tumor and the invasion to portal vein or inferior vena cava. (author)

415

Theoretical, clinical and pharmacokinetic aspects of cancer chemotherapy administered by continuous infusion  

International Nuclear Information System (INIS)

This chapter reviews some of the theoretical and empirical aspects of the administration of anti-cancer drugs by continuous intravenous infusion in conjunction with radiation therapy. The variables contributing to schedule dependence of anti-cancer drugs are discussed. A table shows the improved therapeutic index of Bleomycin by continuous infusion in mice. The use of Cytarabine, a pyrimidine anti-metabolite which kills cells during S-phase or DNA synthesis, is examined. Fluorouracil and Doxorubicin are examined and several other drugs including vincristine, vinblastine, etoposide, and cisplatin are discussed

416

Plasma concentrations of fentanyl with subcutaneous infusion in palliative care patients.  

OpenAIRE

1. Plasma concentrations of fentanyl were measured by g.c. in 20 patients (median age: 75 years and range: 54-86 years; eight females) in palliative care receiving the drug by continuous s.c. infusion (median rate: 1200 micrograms day-1 and range: 100-5000 micrograms day-1). 2. The infusion rate was significantly related to the duration of therapy (Spearman rho = 0.56, P < 0.05). The total steady-state plasma concentrations of fentanyl ranged between 0.1 and 9 ng ml-1, with a median of 1 ng m...

Miller, R. S.; Peterson, G. M.; Abbott, F.; Maddocks, I.; Parker, D.; Mclean, S.

1995-01-01

417

Topotecan given as a 21-day infusion in the treatment of advanced ovarian cancer  

OpenAIRE

A phase II programme was carried out in both Europe and North America to evaluate the activity of topotecan administered as a 21-day continuous intravenous infusion to patients with recurrent ovarian cancer. The European results are reported here. Patients who had failed first line therapy with a platinum-based regimen received topotecan 0.4?mg/m2/day, as a 21-day infusion every 28 days. Patients were only permitted one prior regimen. 35 patients were enrolled and evaluable for response. 3 ...

Gore, M.; Rustin, G.; Schu?ller, J.; Lane, S. R.; Hearn, S.; Beckman, R. A.; Ross, G.

2001-01-01

418

5 FU infusion with mitomycin-C vs. 5 FU infusion with methyl-CCNU in the treatment of advanced upper gastrointestinal cancer: a Southwest Oncology Group Study.  

Science.gov (United States)

A randomized trial was conducted by the Southwest Oncology Group (SWOG) in advanced carcinoma of the stomach and pancreas. Patients were assigned to receive monthly 5-fluorouracil 96-hour continuous infusions with either bolus mitomycin-C or oral methyl-CCNU. Mitomycin-C and methyl-CCNU were administered every eight weeks. The 5 FU-mitomycin combination produced a 14% and 22% response rate in disseminated stomach and pancreatic carcinoma, respectively. The combination of infusion 5 FU and methyl-CCNU achieved responses in 9% and 5% of stomach and pancreatic tumors, respectively. There was no significant difference in survival between limbs for either tumor. Median survival in gastric carcinoma on the 5 FU-mitomycin regimen was 25 weeks vs. 18 weeks on the 5 FU-METHYL-CCNU arm. In pancreatic carcinoma median survival on the mitomycin limb was 19 weeks as compared to 17 weeks on the methyl-CCNU program. Leukopenia was greater for the first course on the mitomycin limb. Regression analysis demonstrated that performance status was the most important pretreatment characteristic for predicting survival in both tumors. Neither 5 FU infusion combination appears to significantly alter the dismal prognosis of advanced upper gastrointestinal neoplasms. PMID:387204

Buroker, T; Kim, P N; Groppe, C; McCracken, J; O'Bryan, R; Panettiere, F; Costanzi, J; Bottomley, R; King, G W; Bonnet, J; Thigpen, T; Whitecar, J; Haas, C; Vaitkevicius, V K; Hoogstraten, B; Heilbrun, L

1979-10-01

419

Effect of a povidone-iodine intrauterine infusion on progesterone levels and endometrial steroid receptor expression in mares  

OpenAIRE

Abstract Background Intrauterine infusions have been widely used for the treatment of endometritis in the mare. Nevertheless, their consequences on endocrine and endometrial molecular aspects are unknown. We studied the effect of a 1% povidone-iodine solution intrauterine infusion on progesterone levels, endometrial histology and estrogen (ER?) and progesterone (PR) receptor distribution by immunohistochemistry. Methods Fourteen healthy mares were used in this ...

Talmon Marilina; Rivero Rodolfo; Perdigón Fernando; Kalpokas Irene; Sartore Isabel; Viñoles Carolina

2010-01-01

420

Multiple intravenous infusions of bone marrow mesenchymal stem cells reverse hyperglycemia in experimental type 2 diabetes rats.  

Science.gov (United States)

The worldwide rapid increase in diabetes poses a significant challenge to current therapeutic approaches. Single-dose mesenchymal stem cell (MSC) infusion ameliorates hyperglycemia but fails to restore normoglycemia in diabetic animals. We therefore hypothesized that multiple intravenous MSC infusions may reverse hyperglycemia in type 2 diabetes (T2D) rats. We administered serial allogenous bone-marrow derived MSC infusions (1 × 10(6)cells/infusion) via the tail vein once every 2 weeks to T2D rats, induced by high-fat diet and streptozocin (STZ) administration. Hyperglycemia decreased only transiently after a single infusion in early-phase (1 week) T2D rats, but approximated normal levels after at least three-time infusions. This normal blood level was maintained for at least 9 weeks. Serum concentrations of both insulin and C-peptide were dramatically increased after serial MSC infusions. Oral glucose tolerance tests revealed that glucose metabolism was significantly ameliorated. Immunofluorescence analysis of insulin/glucagon staining revealed the restoration of islet structure and number after multiple MSC treatments. When multiple-MSC treatment was initiated in late-phase (5 week) T2D rats, the results were slightly different. The results of this study suggested that a multiple-MSC infusion strategy offers a viable clinical option for T2D patients. PMID:23770360

Hao, Haojie; Liu, Jiejie; Shen, Jing; Zhao, Yali; Liu, Huilin; Hou, Qian; Tong, Chuan; Ti, Dongdong; Dong, Liang; Cheng, Yu; Mu, Yiming; Liu, Jianping; Fu, Xiaobing; Han, Weidong

2013-07-01

421

Safety of and tolerance to adenosine infusion for myocardial perfusion single-photon emission computed tomography in a Japanese population  

International Nuclear Information System (INIS)

Adenosine has been available for use in myocardial perfusion single-photon emission computed tomography (SPECT) in Japan since 2005. The purpose of this study was to evaluate the safety of and tolerance to thallium-201 myocardial perfusion SPECT with intravenous adenosine infusion in Japanese patients with suspected coronary artery disease. Two hundred and six consecutive patients who underwent an adenosine infusion (120 ?g·kg-1·min-1) SPECT at Sumitomo Besshi Hospital (Niihama, Japan) were investigated. The effects of adenosine infusion were monitored for each patient. A coronary angiography was performed in 81 patients. Adenosine infusion significantly decreased blood pressure and increased heart rate. Adverse reactions were observed in 161 patients (78.2%). Most reactions were transient, disappearing soon after the termination of adenosine infusion. No serious adverse reactions, such as acute myocardial infarction or death, occurred. Adenosine infusion was terminated in 3 patients (1.5%) because of near syncope or sustained 2:1 atrioventricular block. Electrocardiographic changes occurred in 15 patients (7.3%). Self-assessed scoring after SPECT showed that the patients were very tolerant (74.6% of 177 patients) of adenosine infusion myocardial SPECT. The sensitivity and specificity were 75.0% and 69.7%, respectively. Adenosine infusion myocardial SPECT is safe and well tolerated in the Japanese population, despite the frequent occurrence ofion, despite the frequent occurrence of minor adverse reactions. (author)

422

EC infuses Serbian nuclear relic cleanup with critical donation  

International Nuclear Information System (INIS)

Full text: As part of the Vinca Institute Nuclear Decommissioning (VIND) Programme, the Serbian government and the IAEA recently signed an $8.63 million (EUR 5.46 million) framework agreement with the European Commission to help fund activities related to decommissioning of the aging Cold War-era nuclear reactor. The European donation is the largest in the project's history, and the infusion of funds is vital to complete a crucial stage of the decommissioning programme. 'Thanks to the impressive contribution by the European Commission, we're one step closer to completing this important and complex project,' said John J. Kelly, the IAEA's Special Programme Manager for VIND. 'With radioactive waste, disused sources, and leaking spent fuel that's almost 45 years old, the Vinca site presents huge radiological challenges.' The task at Vinca is a mammoth undertaking, and the work is split into three major projects. In the first and most expensive project, old Soviet fuel, some of which is high-enriched uranium (HEU) that could be converted to weapons-grade material, must be safely repackaged and then prepared and repatriated to Russia for reprocessing. Once completed, the VIND spent fuel shipment will comprise the largest shipment of spent research reactor fuel in the European theatre, and extra shipping casks have already been built for the project through funding received from the USA. In the second VIND project, thousands of containers of unprocessed radioactive waste and disused sealed radioactive sources must be removed from old, degraded storage buildings, conditioned and packaged for safe, secure storage, and placed into new storage facilities, The new storage facilities are currently under construction and should be ready later this year. The third VIND project focuses on decommissioning of the research reactor. The reactor's draft decommissioning plan is almost finished, and plans are in place to begin some decommissioning and dismantlement activities in 2009. In addition to the radiological legacy at Vinca, security had long been a source of concern. The reactor has been offline since 1984, and much of the dangerous material and facilities were inadequately protected. Thanks to funding and other support activities provided by the Serbian government and the USA for security upgrades and police support, overall site security has been substantially improved over the past two years. Yet more needs to be done, and time is running out. Along with the EC's recent donation, an additional $25 million must be raised by 2010 to meet a crucial deadline. The fuel needs to be shipped back to Russia by the end of 2010 or the job falls off the shipping schedule, and potential funding for VIND would also dry up should the 2010 target date be missed. VIND is the largest one-house programme within the IAEA, and the EC contribution is the largest single contribution ever received for a Technical Cooperation (TC) national project. 'The EC support was absolutely crucial to the life of the programme, but we have quite a way to go to find the remaining $25 million for the project,' said Kelly. 'The EC contribution serves as a great example and encourages other potential donors to invest in an important and successful project.' Background: Located on the outskirts of Belgrade, the 'Institute for Nuclear Sciences (Vinca)' was set up as a research centre in the former Yugoslavia in the 1950s. A civilian nuclear research reactor loaded with high-enriched uranium was housed at the site. The area was also a central radioactive waste collection and consolidation centre for the former Yugoslavia. The grounds at Vinca accumulated all the former country's dangerous radioactive waste and other radioactive sources for nearly 45 years, and though the reactor went offline in 1984, the radioactive waste and sources received from around the country continued to pile up. International concern about Vinca mushroomed in the 1990s after the break-up of the former Yugoslavia, which led to increased international cooperation to remediate the site and reduce the

423

C-Section  

Science.gov (United States)

C-Section Introduction A Cesarean section, or C-section, is the surgical delivery of a baby through an incision in the abdomen. About 1 out of ... placenta is delivered. Indications A doctor performs a Cesarean section if he or she thinks it is safer ...

424

C-Section  

Medline Plus

Full Text Available C-Section Introduction A Cesarean section, or C-section, is the surgical delivery of a baby through an incision in the abdomen. About 1 out of ... placenta is delivered. Indications A doctor performs a Cesarean section if he or she thinks it is safer ...

425

HPLC Determination of Antilipoxygenase Activity of a Water Infusion of Ligustrum vulgare L. Leaves and Some of Its Constituents  

Directory of Open Access Journals (Sweden)

Full Text Available The aim of the study was a HPLC evaluation of the lipoxygenase activity inhibiting activity of a water infusion of Ligustrum vulgare L. leaves and selected isolates from it. The antiradical activity of the water infusion was determined using DPPH, ABTS and FRAP tests. Oleuropein and echinacoside concentrations in the water infusion were determined by HPLC. Water infusion, echinacoside and oleuropein were used for an antilipoxygenase activity assay using lipoxygenase isolated from rat lung cytosol fraction. Activity of 8-LOX, 12-LOX and 15-LOX were monitored through formation of 8-HETE, 12-HETE and 15-HETE, respectively. The water infusion exhibited the highest activity against all lipoxygenases, followed by oleuropein. Echinacoside was ineffective against LOXs in lower concentrations, while higher concentration showed similar inhibition on 8-LOX and 12-LOX. 15-LOX was affected more and the presence of echinacoside remarkably decreased its activity.

Milan Nagy

2011-09-01

426

Complications following balloon-occluded arterial infusion chemotherapy for pelvic malignancies  

International Nuclear Information System (INIS)

Purpose: To evaluate the incidence and causes of complications associated with balloon-occluded arterial infusion chemotherapy (BOAI) for pelvic malignancies.Methods: In 34 courses of BOAI in 22 patients with pelvic malignancies, we analyzed the incidence of complications as well as the effect of the dose of the anticancer drugs, the infusion site, and the number of BOAI administrations on these complications. Complications were divided into two categories: cystitis-like symptoms and neurological complications such as pain, numbness, and paresthesia of the lower extremities and the hip.Results: Eleven patients (50%) suffered from complications, seven (31.8%) from neurological complications and four (18.2%) from cystitis-like symptoms. The complications appeared in 14 courses (42.4%) of BOAI, neurological complications in 10 (30.3%) and cystitis-like symptoms in four (12.1%). A high dose of anti-cancer drugs and infusion from the anterior division tended to induce neurological complications more frequently; however, the cystitis-like symptoms were not related to any factors.Conclusion: Our results indicate th