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Study protocol. ECSSIT - Elective Caesarean Section Syntocinon Infusion Trial. A multi-centre randomised controlled trial of oxytocin (Syntocinon) 5 IU bolus and placebo infusion versus oxytocin 5 IU bolus and 40 IU infusion for the control of blood loss at elective caesarean section.  

LENUS (Irish Health Repository)

BACKGROUND: Caesarean section is one of the most commonly performed major operations in women throughout the world. Rates are escalating, with studies from the United States of America, the United Kingdom, China and the Republic of Ireland reporting rates between 20% and 25%. Operative morbidity includes haemorrhage, anaemia, blood transfusion and in severe cases, maternal death. The value of routine oxytocics in the third stage of vaginal birth has been well established and it has been assumed that these benefits apply to caesarean delivery as well. A slow bolus dose of oxytocin is recommended following delivery of the baby at caesarean section. Some clinicians use an additional infusion of oxytocin for a further period following the procedure. Intravenous oxytocin has a very short half-life (4-10 minutes) therefore the potential advantage of an oxytocin infusion is that it maintains uterine contractility throughout the surgical procedure and immediate postpartum period, when most primary haemorrhages occur. The few trials to date addressing the optimal approach to preventing haemorrhage at caesarean section have been under-powered to evaluate clinically important outcomes. There has been no trial to date comparing the use of an intravenous slow bolus of oxytocin versus an oxytocin bolus and infusion. METHODS AND DESIGN: A multi-centre randomised controlled trial is proposed. The study will take place in five large maternity units in Ireland with collaboration between academics and clinicians in the disciplines of obstetrics and anaesthetics. It will involve 2000 women undergoing elective caesarean section after 36 weeks gestation. The main outcome measure will be major haemorrhage (blood loss >1000 ml). A study involving 2000 women will have 80% power to detect a 36% relative change in the risk of major haemorrhage with two-sided 5% alpha. DISCUSSION: It is both important and timely that we evaluate the optimal approach to the management of the third stage at elective caesarean section. Safe operative delivery is now a priority and a reality for many pregnant women. Obstetricians, obstetric anaesthetists, midwives and pregnant women need high quality evidence on which to base management approaches. The overall aim is to reduce maternal haemorrhagic morbidity and its attendant risks at elective caesarean section. TRIAL REGISTRATION: number: ISRCTN17813715.

Murphy, Deirdre J

2009-01-01

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Study protocol. ECSSIT - Elective Caesarean Section Syntocinon Infusion Trial. A multi-centre randomised controlled trial of oxytocin (Syntocinon) 5 IU bolus and placebo infusion versus oxytocin 5 IU bolus and 40 IU infusion for the control of blood loss at elective caesarean section.  

LENUS (Irish Health Repository)

BACKGROUND: Caesarean section is one of the most commonly performed major operations in women throughout the world. Rates are escalating, with studies from the United States of America, the United Kingdom, China and the Republic of Ireland reporting rates between 20% and 25%. Operative morbidity includes haemorrhage, anaemia, blood transfusion and in severe cases, maternal death. The value of routine oxytocics in the third stage of vaginal birth has been well established and it has been assumed that these benefits apply to caesarean delivery as well. A slow bolus dose of oxytocin is recommended following delivery of the baby at caesarean section. Some clinicians use an additional infusion of oxytocin for a further period following the procedure. Intravenous oxytocin has a very short half-life (4-10 minutes) therefore the potential advantage of an oxytocin infusion is that it maintains uterine contractility throughout the surgical procedure and immediate postpartum period, when most primary haemorrhages occur. The few trials to date addressing the optimal approach to preventing haemorrhage at caesarean section have been under-powered to evaluate clinically important outcomes. There has been no trial to date comparing the use of an intravenous slow bolus of oxytocin versus an oxytocin bolus and infusion. METHODS AND DESIGN: A multi-centre randomised controlled trial is proposed. The study will take place in five large maternity units in Ireland with collaboration between academics and clinicians in the disciplines of obstetrics and anaesthetics. It will involve 2000 women undergoing elective caesarean section after 36 weeks gestation. The main outcome measure will be major haemorrhage (blood loss >1000 ml). A study involving 2000 women will have 80% power to detect a 36% relative change in the risk of major haemorrhage with two-sided 5% alpha. DISCUSSION: It is both important and timely that we evaluate the optimal approach to the management of the third stage at elective caesarean section. Safe operative delivery is now a priority and a reality for many pregnant women. Obstetricians, obstetric anaesthetists, midwives and pregnant women need high quality evidence on which to base management approaches. The overall aim is to reduce maternal haemorrhagic morbidity and its attendant risks at elective caesarean section. TRIAL REGISTRATION: number: ISRCTN17813715.

Murphy, Deirdre J

2012-02-01

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ECSSIT - Elective caesarean section Syntocinon infusion trial a multi-centre randomized controlled trial oxytocin Syntocinon % iu bolus and placebo infusion versus oxtocin 5 iu bolus and 40 iu infusion for the control of blood loss at elective caesarean section  

LENUS (Irish Health Repository)

Institute of Obstetricians & Gynaecologists, RCPI Four Provinces Meeting, Junior Obstetrics & Gynaecology Society Annual Scientific Meeting, Royal Academy of Medicine in Ireland Dublin Maternity Hospitals Reports Meeting, Nov 2010

Sheehan, S

2011-02-01

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Comparison of Ephedrine infusion and crystalloid preload in maintaining blood pressure in cesarean section under spinal anesthesia  

Directory of Open Access Journals (Sweden)

Full Text Available Hypotention is hazardous for fetus and mother under spinal anesthesia in cesarean section. Prophylactic effect of crystalloid preload and ephedrine infusion were compared in preventing of hypotention in these patients. From the cases, 44 women candidate for elective cesarean section were randomly divided in two groups. In first group, 15 ml per kg Ringer infused before spinal anesthesia. In the second group, Ephedrine infusion 0.25 mg/kg/3 min started immediately after spinal. During the section, BP was more stable in second group than the first group. Therefore ephedrine infusion seems to be more effective in controlling of BP in these patients.

Sadeghy Poor Roodsary H

2001-10-01

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Continuous infusion of recombinant activated factor VII during caesarean section delivery in a patient with congenital factor VII deficiency.  

Science.gov (United States)

Recombinant activated factor VII (rFVIIa) can be used as an alternative therapy in patients with FVII deficiency. However, as the drug has a very short half-life, continuous infusion could be a meaningful administration modality. We report the case of a 30-year-old woman with moderate FVII deficiency and human immunodeficiency virus infection who underwent a caesarean section delivery. She was treated with a continuous infusion of rFVIIa and did not suffer any bleeding complication. The continuous infusion of rFVIIa was a safe and effective therapeutic approach for our patient, maintaining her levels of FVII:C and avoiding bleeding during caesarean section and afterwards. PMID:11012708

Jiménez-Yuste, V; Villar, A; Morado, M; Canales, M; Hernández, M C; Sanjurjo, M J; Quintana, M; Hernández-Navarro, F

2000-09-01

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Induction of Labor Using Native (OXYTIP) in Comparison to Foreign Oxytocin (SYNTOCINON)  

Science.gov (United States)

Objective This study was conducted with the aim to investigate and compare Iranian produced and foreign oxytocin for use in induction of labor. Materials and methods This random clinical trial was conducted on a population of 198 pregnant women with live fetus and cephalic presentation and conditions conducive to induction of labor, monitored by obstetricians and gynecologists. They were randomly divided into group A (n = 99) received 10 units of Syntocinon (Novartis Pharma Canada) in 500 cc Ringer lactate, and group B (n = 99) received 10 units of Oxytip (Caspian Tamin Company Iran) in 500 cc serum, who entered the study to commence induction, by signing written consent. Study variables such as induction indications (post-term, ruptured membranes, diabetes, and..), induction duration, duration of the 1st and the 2nd stages of labor, and delivery method; as well as labor outcomes like hyper-stimulation of uterine, postpartum bleeding, 5-minute Apgar score, and infant's birth weight; and neonatal outcomes (admission to NICU, oxygen and intubation) were assessed for the two groups by a trained midwife and registered in the patient's questionnaire. Data were analyzed in SPSS software using statistical tests: t-test, Chi-square, and Mann-Whitney. Results Two groups were similar in demographic variables such as; age, BMI, parity, education. There was no significant difference regarding to obstetric and gynecologic characteristics such as: gestational age, dilatation, effacement, and fetal positioning, as well as the indication for labor induction when the study began. After intervention, variables including: induction duration, duration of the 1st and the 2nd stages of labor, delivery method; and labor outcomes such as: hyper-stimulation of uterine, postpartum bleeding, 5-minute Apgar score, and infant's birth weight; and neonatal outcomes (admission to NICU, oxygen and intubation), in the two groups, were found to be the same (P induction and neonatal complications had similar outcomes and the locally made drug with a lower dosage appears to produce the desired outcome.

Haghollahi, Fedyeh; Khazardoost, Soghra; Hantoushzadeh, Sedigheh; Naghizadeh, Mohammad Mehdi

2014-01-01

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Evaluation of the Effect of Intravenous Lidocaein Infusion on Postoperative Analgesia after Cesarean Section under Spinal Anesthesia  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction & Objective: Many surgical patients still experience moderate to severe pain after surgery despite efforts to administer new drugs and techniques. Postoperative analgesia clearly enhances patient’s satisfaction and facilitates earlier mobilization and rehabilitation. lidocaein has been introduced as part of post operative pain management and clinical studies revealed analgesic actions in patients with chronic neuropathic pain. Our goal in this study was to determine the effect of intravenous lidocaein on post operative pain of women under-going cesarean section under spinal anesthesia. Materials & Methods: In this double blinded clinical trial study, 72 patients candidate for Ce-sarean section under spinal anesthesia were randomly selected and divided in two groups. In the case group, infusion of1.5 mg/kg lidocaein and in the control group infusion of the same volume normal saline started 15 minutes before the beginning of operation. After spinal anes-thesia with definite technique in both groups, infusion of 1.5 mg/kg/h lidocaein in case group and the same volume normal saline in the control group was administered and continued till 0.5 hour after finishing the operation. Data including systolic and diastolic blood pressure, heart rate, analgesic score according VAS and using of analgesic drugs were recorded during 24 hours after the operation. Results: Pain intensity according to VAS score in the time 2,6,12 hours post operation were significantly lower in the case group ( P2= 0.05, P6 = 0.01, P12= 0.05 .Analgesic consumption in form of suppository & IV,24 hours after surgery, was significantly lower in the case group.(P=0.001. Conclusion: Lidocaein infusion can decrease pain intensity & analgesic consumption after ce-sarean section under spinal anesthesia. (Sci J Hamadan Univ Med Sci 2013; 20 (1:9-14

M. H. Bakhshaei

2013-04-01

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A randomised controlled trial of oxytocin 5IU and placebo infusion versus oxytocin 5IU and 30IU infusion for the control of blood loss at elective caesarean section--pilot study. ISRCTN 40302163.  

LENUS (Irish Health Repository)

OBJECTIVE: To compare the blood loss at elective lower segment caesarean section with administration of oxytocin 5IU bolus versus oxytocin 5IU bolus and oxytocin 30IU infusion and to establish whether a large multi-centre trial is feasible. STUDY DESIGN: Women booked for an elective caesarean section were recruited to a pilot randomised controlled trial and randomised to either oxytocin 5IU bolus and placebo infusion or oxytocin 5IU bolus and oxytocin 30IU infusion. We wished to establish whether the study design was feasible and acceptable and to establish sample size estimates for a definitive multi-centre trial. The outcome measures were total estimated blood loss at caesarean section and in the immediate postpartum period and the need for an additional uterotonic agent. RESULTS: A total of 115 women were randomised and 110 were suitable for analysis (5 protocol violations). Despite strict exclusion criteria 84% of the target population were considered eligible for study participation and of those approached only 15% declined to participate and 11% delivered prior to the planned date. The total mean estimated blood loss was lower in the oxytocin infusion arm compared to placebo (567 ml versus 624 ml) and fewer women had a major haemorrhage (>1000 ml, 14% versus 17%) or required an additional uterotonic agent (5% versus 11%). A sample size of 1500 in each arm would be required to demonstrate a 3% absolute reduction in major haemorrhage (from baseline 10%) with >80% power. CONCLUSION: An additional oxytocin infusion at elective caesarean section may reduce blood loss and warrants evaluation in a large multi-centre trial.

Murphy, Deirdre J

2012-02-01

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Current use of intraosseous infusion in Danish emergency departments: a cross-sectional study  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Intraosseous infusion (IOI is recommended when intravenous access cannot be readily established in both pediatric and adult resuscitation. We evaluated the current use of IOI in Danish emergency departments (EDs. Methods An online questionnaire was e-mailed to the Heads of Department of the twenty EDs currently established in Denmark. The questionnaire focused on the use of IOI in the EDs and included questions on frequency of use, training, equipment and attitudes towards IOI. Results We received a total of 19 responses (response rate of 95%. Of the responding 19 Danish EDs 74% (n = 14 reported having intraosseous devices available. The median number of IOI procedures performed in these departments over the preceding 12 months was 5.0 (range: 0-45. In 47% (n = 9 of the departments, prior training sessions in the use of intraosseous devices had not been provided, and 42% (n = 8 did not have local guidelines on IOI. The indication for IOI use was often not clearly defined and only 11% (n = 2 consistently used IOI on relevant indication. This is surprising as 95% (n = 18 of responders were aware that IOI can be utilized in both pediatric and adult resuscitation. Conclusions The study shows considerable variations in IOI usage in Danish EDs despite the fact that IOI devices were available in the majority of EDs. In addition, in many EDs there were no local guidelines on IOI and no training in the procedure. We recommend more extensive training of medical staff in IOI techniques in Danish EDs.

Brabrand Mikkel

2010-07-01

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Oxytocin bolus versus oxytocin bolus and infusion for control of blood loss at elective caesarean section: double blind, placebo controlled, randomised trial.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

OBJECTIVES: To determine the effects of adding an oxytocin infusion to bolus oxytocin on blood loss at elective caesarean section. DESIGN: Double blind, placebo controlled, randomised trial, conducted from February 2008 to June 2010. SETTING: Five maternity hospitals in the Republic of Ireland. PARTICIPANTS: 2069 women booked for elective caesarean section at term with a singleton pregnancy. We excluded women with placenta praevia, thrombocytopenia, coagulopathies, previo...

Gleeson, Ronan Patrick; Murphy, Deirdre

2011-01-01

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21 CFR 880.6990 - Infusion stand.  

Science.gov (United States)

...2010-04-01 2010-04-01 false Infusion stand. 880.6990 Section 880.6990...Use Miscellaneous Devices § 880.6990 Infusion stand. (a) Identification. The infusion stand is a stationary or movable stand...

2010-04-01

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IT infusion  

Science.gov (United States)

Infusing IT technology is a perennial challenge. The Technology Infusion and Maturity Assessment approach of Cornford & Hicks is shown applied to an example of IT infusion: moedl-based V&V of spacecraft software.

Feather, M. S.

2002-01-01

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Infusion extractor  

Science.gov (United States)

This invention relates to an apparatus and method of removing desirable constituents from an infusible material by infusion extraction. A piston operating in a first chamber draws a solvent into the first chamber where it may be heated, and then moves the heated solvent into a second chamber containing the infusible material, where infusion extraction takes place. The piston then moves the solvent containing the extract through a filter into the first chamber, leaving the extraction residue in the second chamber. The method is applicable to operation in low or micro-gravity environments.

Chang-Diaz, Franklin R. (inventor)

1986-01-01

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Induction of labor using double balloon cervical device in women with previous cesarean section: Experience and review  

Directory of Open Access Journals (Sweden)

Full Text Available Induction of labour remains one of the most challenging interventions in current obstetrics. Different pharmaceuticals have been used for cervical ripening such as prostaglandins; however they can lead to a number of potential inconvenient risks namely uterine tachysystole and pathological fetal cardiotocography (CTG. In cases of women with previous caesarean births, using prostaglandins would pose even higher risks such as uterine rupture and perinatal mortality. A mechanical method of cervical ripening could represent an alternative for these women. We report the use of the extra-amniotic double balloon cervical device (Cook’s device for ripening of unfavourable cervix in seventeen women attempting vaginal birth after cesarean section (VBAC. Using Bishop scoring system to assess cervical dilatetion, position, consistency, fetal station and effacement, the unfavourable cervix is the cervix that scores less than 6. We review the relevant literature discussing this method of induction focusing on its effectiveness, simplicity, safety and efficacy, low cost and any associated serious side effects. Conclusion: Success was estimated to be over 50% with no serious life threatening maternal or fetal complications. We considered the process satisfactory and practical. We recommend larger studies to assess safety and efficacy of Cook’s device in vaginal birth after caesarean section before embarking on routine elective caesarean delivery. Objectives: To estimate success rate for vaginal delivery after previous caesarean section using cervical double balloon device (Cook’s device. Design: Three-year observational study. Setting: Maternity unit in district general hospital, UK. Population: Women who had one previous lower segment caesarean section and unfavourable cervix identified as having Bishop Score less than 6. Methods: Data were obtained from the birth registry over 3 years from January 2008 until December 2010. Main outcome: Measure successful vaginal delivery. Results: Out of 25 cases that had induction of labour with history of one previous lower segment caesarean section, 17 patients did fit in the inclusion criteria and were studied. 53% had a successful vaginal delivery while 47% had to have cesarean section either due to failure to progress or pathological cardiotocography. 82% required to have syntocinon infusion for augmentation as per local unit protocol. All newborn babies were in good condition and did not require admission to neonatal intensive care unit.

N. Nassif

2013-03-01

15

[Infusion solutions].  

Science.gov (United States)

Infusion solutions or preparations for intravenous administration have been developed since 1830 after the work of Thomas Latta. This particular pharmaceutical form, which brings large accounts of liquid (100 to 3000 ml) and nourishes, equilibrates, hydrates, clears, serves as a vehicule for many drugs and allows organ storage, has had a considerable development owing to its successes in a number of severe diseases and because it has supported the emergence of critical care and intensive care medicine. This form has an unappreciated story. It was first used in hospitals but it is now manufactured by the pharmaceutical industry after a long series of technical improvements and galenic innovations bringing solutions to the problems successively encountered (microbial contamination, embolism, blood alteration, "saline fever", degradation and adsorption of drugs, allergic shock...) and answers to the new requirements resulting from progresses in physiology and biology (hydroeletrolytic support, plasma expansion, energy supply, acidobasic homeostasis, malnutrition...). This story is depicted with respect to the indications, the formulation, the infusion devices from the origin to nowadays. PMID:14606483

Dauphin, Alain; Cazalaa, Jean-Bernard; Pradeau, Dominique; Chaouky, Hamitha; Saince-Viard, Dominique

2003-01-01

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21 CFR 880.5965 - Subcutaneous, implanted, intravascular infusion port and catheter.  

Science.gov (United States)

...Subcutaneous, implanted, intravascular infusion port and catheter. 880.5965 Section...Subcutaneous, implanted, intravascular infusion port and catheter. (a) Identification...subcutaneous, implanted, intravascular infusion port and catheter is a device...

2009-04-01

17

21 CFR 526.464b - Cloxacillin benzathine for intramammary infusion, sterile.  

Science.gov (United States)

...Cloxacillin benzathine for intramammary infusion, sterile. 526.464b Section 526...Cloxacillin benzathine for intramammary infusion, sterile. (a) Specifications...slaughtered for food from the time of infusion until 72 hours after calving....

2010-04-01

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21 CFR 526.464a - Cloxacillin benzathine for intramammary infusion.  

Science.gov (United States)

...Cloxacillin benzathine for intramammary infusion. 526.464a Section 526.464a...Cloxacillin benzathine for intramammary infusion. (a) Specifications. Each dose...food use for 30 days after the latest infusion. Federal law restricts this drug...

2009-04-01

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21 CFR 526.1696c - Penicillin G procaine-dihydrostreptomycin sulfate for intramammary infusion (dry cows).  

Science.gov (United States)

...procaine-dihydrostreptomycin sulfate for intramammary infusion (dry cows). 526.1696c Section...procaine-dihydrostreptomycin sulfate for intramammary infusion (dry cows). (a) Specifications...food within 60 days from the time of infusion nor within 96 hours after...

2010-04-01

20

Intraosseous Infusion Device.  

Science.gov (United States)

A device for infusion or aspiration that includes a base and at least one needle positioned within the base, where the base includes one or more locators for positioning the infusion device in relation to one or more predetermined anatomical features. A d...

D. Nedder J. F. Stokes M. J. Turieo R. P. Maloney R. W. Etheredge

2005-01-01

 
 
 
 
21

Continuous-infusion adriamycin  

International Nuclear Information System (INIS)

This chapter discusses the diminished cardiotoxicity as well as diminished nausea and vomiting with continuous infusions of adriamycin to patients undergoing radiation therapy, particularly with infusions of 48 hours or longer, and best with 96-hour infusions, the longest duration that has been studied systematically. In breast cancer, data show that more adriamycin is better, but only for a selected subgroup of patients: those with complete remission. The diminished cardiotoxicity makes the use of adriamycin more attractive in the adjuvant situation, where increased safety will decrease the chances of long-term complications and make retreatment easy for cured patients who develop second malignancies

1986-01-01

22

Continuous radioisotope infusion  

International Nuclear Information System (INIS)

Continuous infusion of a radioactive marker was used instead of a conventional bolus injection to improve haemodynamic studies. Tc-99m was infused into the blood circulation at a constant rate for 100-300 seconds and the activity in the target structure was measured by a gamma camera with a computer system or by a single detector. The concentration of the marker increased linearly at the same rate throughout the circulating system. Due to variations in transport time from infusion site to different parts of the system the rise of activity occurred at different times. A theory for the calculations was presented and consequently confirmed in a model study. Blood flow patterns in artificial kidneys and alterations in renal blood flow induced by angiotensin were studied. The results are presented as time-function curves or as computer images. This technique can be used to evaluate distributions and alterations of flow in separate parts of a complex circulating system. (author)

1978-01-01

23

Rockburst prevention by infusion  

Energy Technology Data Exchange (ETDEWEB)

The Sonnenschein seam at Nordstern-Zollverei colliery in the FRG is rock-burst prone; it was decided to carry out preproduction infusion in the Zollverein panel. A total of 34 infusion holes were drilled to depths of 30, 45, 60 and 75m; seam reactions were recorded during drilling. Water at a pressure of 300 bar was pumped into the holes and the holes closed with wooden wedges and polyurethane. During production, the face was monitored by 10m deep test holes along the face. 1 fig.

Reiss, R.; Kasimir, F.; Klammer, G.

1988-01-01

24

Coal-face infusion. Kohlenstosstraenken  

Energy Technology Data Exchange (ETDEWEB)

Trials with continuous infusion methods were run in 22 collieries. Longwall infusion was used either for the first time or as an alternative to other infusion techniques. Several collieries stepped up the development of long drill holes achieving depths of up to 184 m by increasing drilling water pressure and associated adequate water quantities. A measuring device was used to determine the direction and inclination of the drill holes. Addition of fluorescine sodium to the infusion water allowed the course of the water to be verified across a distance of 70 m. A carriage-type drilling machine was equipped with electric sensors to establish drilling-machine-specific data. New cement mixtures were developed to achieve better drill hole sealing in longwall infusion. New transducers were installed to begin with the acquisition of infusion water quantity data and their transmission to the central mine control station. (orig.).

Becker, H.; Betting, K.; Korth, H.; Stockmann, H.W.; Goeretz, H. (Steinkohlenbergbauverein, Essen (Germany, F.R.). Hauptstelle fuer Staubbekaempfung und Pneumokonioseverhuetung)

1989-01-01

25

Thallium-201 infusion imaging  

International Nuclear Information System (INIS)

To test the accuracy of Thallium-201 coronary artery infusion imaging of the earth during rapid changes in blood flow through a major coronary artery, the author performed a study in dogs correlating electromagnetic flow probe recordings with 201Tl scintillation camera acquisitions. Hyperemic vascular response was produced experimentally in a major coronary artery by occlusion and release interventions which altered flow from baseline to zero during occlusion (20 seconds), followed by rapid flow increases approaching three times baseline immediately upon release of the occlusion. Flow returned to the baseline level within 60 seconds following release. Flow was also altered in a controlled fashion by other interventions. Recordings of Thallium uptake in the myocardium were displayed as a time histogram (counts per second squared vs time) which correlated very closely with electromagnetic flow probe recordings of flow (R=o.82-0.97). These experiments demonstrate a high degree of accuracy in Thallium infusion imaging to detect rapid changes in flow through a major coronary artery

1988-01-01

26

[Development of smart infusion system].  

Science.gov (United States)

The free care smart infusion system which has the function of liquid end alarm and automatic stopping has been designed. In addition, the system can send the alarm to the health care staff by Zigbee wireless network. Besides, the database of infusion information has been set up, it can be used for inquiry afterwards. PMID:24839846

Li, Junyang

2014-01-01

27

[Intraduodenal infusion of levodopa].  

Science.gov (United States)

In the advanced stages of Parkinson's disease (PD), the conventional orally-administered pharmacological treatment can prove to be insufficient to control the motor complications associated with the disease. One of the causes involved in the genesis of the motor fluctuations that are observed in PD is the variable absorption of the medication due to an irregular or erratic emptying of the gastric content. Today, a method of therapy is now available that allows levodopa to be administered directly into the duodenum at a continuous rate by a perfusor. The medication is applied through a duodenal catheter implanted by means of a percutaneous endoscopic gastrostomy. This new form of administration has been marketed under the name of Duodopa, which is a pharmaceutical form of levodopa in a micronised suspension in a thickening gel consisting of sodium carmelose. It is presented in combination with levodopa (20 mg/mL) and a dopa decarboxylase inhibitor, carbidopa (5 mg/mL). Duodopa has proved to be effective in reducing the percentage of off time and in diminishing the periods with disabling dyskinesias. This therapy has also proved to be useful for relieving certain non-motor aspects associated with PD and presents fewer limitations regarding indication for advanced PD patients than those that usually exist for the case of deep brain stimulation. Although the therapy has proved to be effective, it is not free of complications arising from malfunctioning of the infusion system or in relation to the percutaneous endoscopic gastrostomy. PMID:20568067

Valldeoriola, Francesc; Cámara, Ana

2010-07-01

28

[Clinical use of infusion pumps with rotors in occlusive tracts].  

Science.gov (United States)

The authors used in clinical practice an infusion pump driven by a rotation system with an occlusive pathway whereby the movement of the rotor is ensured by a stepper with reduction of the steps to 12,800 microsteps per revolution. As regards the degree of mechanical damage of the inserted tube of the infusion set this system did not differ from the keyboard system which is used by the majority of manufacturers as the driving unit of infusion pumps. Mechanical damage of the infusion set made from PVC was evaluated by the authors with regard to the amount of phthalic acid extracts which are added to PVC as softening agents and are not chemically linked. The authors recorded an increase of the temperature of the infusion solution during the flow through the driving unit in both investigated systems, however, the increase was smaller in the keyboard system. The increase of temperature was, however, in both instances small and has no impact on clinical practice. Contrary to the infusion pump with the keyboard system, the infusion pump with a rotor in an occlusive pathway and a microstep motor (12,800 microsteps per revolution) was significantly more accurate as regards dosage (evaluated as the difference between the required and actually achieved value of flow). The revealed difference was statistically significant at the 1% level. This greater precision of dosage can be ascribed to the point compression of the inserted and to the microvibrations transmitted from the rotor to the inserted tube of the infusion set which helps to recover after every compression the original volume (circular shape of section) of the inserted tube. PMID:8928410

Sevela, K; Gajd?sková, V; Havránková, V; Havlát, F; Krifta, P; Jarosová, A

1996-06-01

29

De-stressing infusion in level workings susceptible to rock bursts  

Energy Technology Data Exchange (ETDEWEB)

De-stressing drilling and infusion were used in conjunction on a seam in level to moderately inclined deposits at Consolidation Colliery. The limits for de-stressing infusion were delineated. In sections of the seam constrained by washouts or faulting, and where pressure weighting is high, de-stressing infusion is not as effective. In such areas, de-stressing drilling was used. The results from a large number of de-stressing holes and infusion tests are analysed. They show that the success of de-stressing infusion is intimately linked with careful monitoring. It is clear that de-stressing infusion takes much less time and is far cheaper than de-stressing drilling.

Grosskreuz, H.

1984-08-09

30

Water infusion for coal-mine dust control: three case studies. Report of Investigations/1987  

Energy Technology Data Exchange (ETDEWEB)

This Bureau of Mines report discusses recent applications of water infusion technology to control dust in U.S. coal mines and presents recommended guidelines for determining coal-seam infusibility. The techniques required to use water infusion are presented in detail. A Bureau case study indicated that water infusion reduced dust levels by 68% along a longwall plow face, bringing this section into compliance with the 2.0-mg/cu m Federal dust standard. Similar studies conducted by Occidental Research Corp. under a Bureau contract show that water infusion at two longwall double-drum shearer operations produced dust reductions ranging from 38 to 50%. Water infusion was found to be cost effective, averaging 5 cents per ton.

McClelland, J.J.; Organiscak, J.A.; Jankowski, R.A.; Pothini, B.R.

1987-01-01

31

Abandonment of infusion in production workings in the Ruhr coalfield; Traenkverzicht in Gewinnungsbetrieben im Ruhrkarbon  

Energy Technology Data Exchange (ETDEWEB)

Infusion of coal before extraction is a measure to reduce dust both from the point of view of health protection as well as fire and explosion protection. However, the effectiveness of infusion is higher in highly coalified sections of seams than in sections with low coalification. The highly effective dust suppression measures in the area of coal winning by cutting and stripping have meanwhile allowed the infusion effect to recede into the background, so that it is possible to dispense with this measure in seam areas with low coalification. It was proved in practical tests that the effectiveness of the infusion is no longer detectable, if optimised secondary dust suppression methods are used. Nowadays infusion work can be dispensed with in stratigraphically young seams during coal winning, if it is guaranteed that mining authority requirements to ensure lower dust pollution are met. (orig.)

Kadow, T.; Suedhofer, F. [Deutsche Steinkohle AG, Herne (Germany); Henke, B.

2004-03-18

32

The use of a volumetric infusion pump for the intra-arterial infusion of drugs.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Volumetric infusion pumps are widely used for intravenous infusions. We have extended their use to the intra-arterial infusion of drugs. An in vitro evaluation of the performance of such devices, under experimental conditions comparable to an intra-arterial infusion, was carried out. The results obtained confirmed the accuracy of volumetric infusion pumps for intra-arterial infusions. The system was found to be safe, reliable and simple in clinical practice.

Cooper, A. M.; Lilliman, M.

1985-01-01

33

Survival of intravenous chemotherapy infusion sites.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Factors associated with the failure of intravenous infusions due to phlebitis and extravasation were studied with 218 infusions delivering cytotoxic drugs. The survival rate of these infusions was not significantly different from that of 56 non-cytotoxic infusions in oncology patients. Although survival analysis indicated that cisplatin was associated with longer survival, this was probably an artifact caused by this drug usually being preceded by 24 h prehydration. Multivariate analysis indi...

Hecker, J. F.

1990-01-01

34

Hypodermoclysis: an alternative infusion technique.  

Science.gov (United States)

Hypodermoclysis, the subcutaneous infusion of fluids, is a useful and easy hydration technique suitable for mildly to moderately dehydrated adult patients, especially the elderly. The method is considered safe and does not pose any serious complications. The most frequent adverse effect is mild subcutaneous edema that can be treated by local massage or systemic diuretics. Approximately 3 L can be given in a 24-hour period at two separate sites. Common infusion sites are the chest, abdomen, thighs and upper arms. The preferred solution is normal saline, but other solutions, such as half-normal saline, glucose with saline or 5 percent glucose, can also be used. Potassium chloride can be added to the solution bag if needed. Hyaluronidase can also be added to enhance fluid absorption. Hypodermoclysis can be administered at home by family members or a nurse; the technique should be familiar to every family physician. PMID:11730312

Sasson, M; Shvartzman, P

2001-11-01

35

What is Nano-Infusion?  

Science.gov (United States)

This page from Nano-Link describes Nano-Infusion. This program "promotes integration and inclusion of nanoscale concepts into high school and college level education." Teachers are encouraged to join the free program to obtain training, support, and nano-related supplies that will aid in introducing nano experiments into their classrooms. To join the program, applicants merely need to create an account on the Nan-Link website and complete and introductory survey.

2012-11-08

36

Interdependence between fissures caused by water infusion and natural fissure system of a coal seam  

Energy Technology Data Exchange (ETDEWEB)

The effects are investigated of the natural fissure system in a coal seam on fissures caused by water infusion into coal seams in the im. 9 Pyatiletki coal mine. Coal seam from 1.9 to 2.1 m thick was prone to rock bursts. Water infusion was used for rock burst prevention; 9568 m/sup 3/ of water were injected using pressure from 16.5 to 29.8 MPa. Infusion rate amounted to 65 l/s. Four fissure systems were analyzed. Data on fissure systems in the infusion zone and in coal seam zones not influenced by water infusion were analyzed. Investigations showed that the natural fissure system in a coal seam was the major channel of water propagation in the seam. Water infusion reduced fissure density 1.2 to 2.6 times while fissure cross-section increased 10 to 100 times. The natural fissures and fissures caused by water infusion were of the same genetic type. Their parameters and orientation were influenced by factors of random character. Effects of the natural fissure systems in coal seams on efficiency of water infusion into coal seams were evaluated. 1 reference.

Bukhantsov, A.I.

1984-07-01

37

Coal face infusion measures and methods  

Energy Technology Data Exchange (ETDEWEB)

Coal face infusion is the most effective and thus the most important measure for reduction of dust development. Hence it must top the list when planning dust suppression measures. The infusion methods, which can be applied from outside the face, are preferable from the point of view of effectiveness and for operational and economic reasons. Longwall infusion has the highest priority as a dust suppression measure. It must therefore be our aim to widen its field of application by careful planning and coordination of the individual steps with due consideration of the operating conditions such as face length, seam thickness, face advance and distance between infusion holes. The infusion work can be improved by remote transmission of volumetric flow and pressure of the infusion water. An increase in the specific infusion water quantity, which is currently at least 10 l water per solid cubic metre of coal, is desirable. 7 refs., 2 figs., 2 tabs.

Guntau, A.

1989-03-16

38

Continuous duodenal infusions of levodopa.  

Science.gov (United States)

Infusion of carbidopa/levodopa or levodopa through a duodenal tube can facilitate increased mobility and functional ability in individuals with Parkinson's disease when conventional drug therapy is unsuccessful in achieving desired outcomes. Therapy requires appropriate patient selection, ongoing assessment of the patient's physical and emotional needs and collaboration between the patient, nurses and physicians. Determining the amount of medication required to achieve the desired outcomes takes time. Implantable pumps may be a future strategy. Future research should focus on patient and family coping throughout hospitalization and at home so the emotional needs of this specific population can be met. PMID:8270813

Fowler, S B; Bergen, M

1993-10-01

39

Automated Segmentation Tool for Brain Infusions  

Digital Repository Infrastructure Vision for European Research (DRIVER)

This study presents a computational tool for auto-segmenting the distribution of brain infusions observed by magnetic resonance imaging. Clinical usage of direct infusion is increasing as physicians recognize the need to attain high drug concentrations in the target structure with minimal off-target exposure. By co-infusing a Gadolinium-based contrast agent and visualizing the distribution using real-time using magnetic resonance imaging, physicians can make informed decisions about when to s...

2013-01-01

40

75 FR 21641 - Infusion Pumps; Public Meeting; Request for Comments  

Science.gov (United States)

...Docket No. FDA-2010-N-0204] Infusion Pumps; Public Meeting; Request for...announcing a public meeting regarding external infusion pumps. The purpose of the meeting is...current problems associated with external infusion pump use, to help the agency...

2010-04-26

 
 
 
 
41

Strontium-rubidium infusion pump with in-line dosimetry  

International Nuclear Information System (INIS)

A strontium-rubidium infusion system is described which consists of: (a) means for generating rubidium 82 in a solution which can be infused into a patient; (b) means for infusing the solution into a patient; (c) means for measuring the radioactivity present in the solution as it is infused into the patient; and (d) means for controlling the means for infusing in response to the amount of radioactivity which has been infused into the patient

1986-01-01

42

The effect of glucagon on infusion cholangiography  

International Nuclear Information System (INIS)

An assessment has been made of the effects of glucagon on biliary tract opacification during intravenous cholangiography. Two series of infusion cholangiograms were obtained at two investigating centres designated A and B. In series A, 41 patients had ioglycamide infusions at a rate of 0.2833 g min-1 over 1 h. In series B, 31 patients had ioglycamide infusions at a rate of 0.3886 g min-1 over 30 min. Radiographs were taken in both series immediately at the end of the infusion, 10 min later and 30 min after the infusion. Two mg of intravenous glucagon was injected into alternate cases in both series A and B immediately after the first radiograph was taken at the completion of the ioglycamide infusion. Two observers in each series then assessed the radiographic opacification of the biliary system without prior knowledge of which patients had received the glucagon. Delineation of the biliary system was considered better in both series in those patients who received glucagon when compared with the controls. Gallbladder opacification was definitely increased in series A in those receiving glucagon, and a similar tendency was shown in series B. The amount of contrast in the upper intestine was increased in series A in the glucagon group, but not in series B. It is concluded that glucagon improves visualisation of the biliary tract, especially the gallbladder at infusion cholangiography. (author)

1979-01-01

43

Antiproliferative activities of tea and herbal infusions.  

Science.gov (United States)

The consumption of tea and herbal infusions has increased rapidly in recent years. More and more people consume these infusions as daily beverages as well as for health purposes. The aim of this study was to supply new information on the antiproliferative function of these infusions for nutritionists and the general public. The in vitro antiproliferative activities of 60 different tea and herbal infusions on four cancer cell lines were evaluated by MTT assay. The results showed that some infusions strongly inhibited the proliferation of A549 (human lung cancer cells), MCF-7 (human breast cancer cells), HepG2 (human hepatoma cells) and HT-29 (human colon cancer cells), and decreased the viability of these cancer cell lines in a dose-dependent manner. In addition, some bioactive components in the infusions were also separated and determined by HPLC. The results suggested that some tea and herbal infusions may be potential dietary supplements for the prevention and treatment of cancer. PMID:23307138

Li, Fang; Li, Sha; Li, Hua-Bin; Deng, Gui-Fang; Ling, Wen-Hua; Xu, Xiang-Rong

2013-04-25

44

Social and Personal Factors in Semantic Infusion Projects  

Science.gov (United States)

As part of our semantic data framework activities across multiple, diverse disciplines we required the involvement of domain scientists, computer scientists, software engineers, data managers, and often, social scientists. This involvement from a cross-section of disciplines turns out to be a social exercise as much as it is a technical and methodical activity. Each member of the team is used to different modes of working, expectations, vocabularies, levels of participation, and incentive and reward systems. We will examine how both roles and personal responsibilities play in the development of semantic infusion projects, and how an iterative development cycle can contribute to the successful completion of such a project.

West, P.; Fox, P. A.; McGuinness, D. L.

2009-12-01

45

Thrombolytic treatment for acute ischemic cerebral stroke: intraarterial urokinase infusion vs. intravenous heparin and urokinase infusion  

International Nuclear Information System (INIS)

To evaluate the efficacy and limitation of intra-arterial urokinase (IAUK) infusion for treatment of acute cerebral stroke. Twenty-seven acute cerebral stroke patients treated with IAUK infusion within six hours of stroke onset were reviewed. All patients showed normal initial brain findings on CT. In 21 patients, urokinase(5-15 x 105IU) was administered through a microcatheter placed into or proximal to occluded segment. Mechanical disruption of thrombus by guidewire was performed in 17 patients. Angiographic and clinical responses and complications after IAUK infusion, were evaluated and the results were compared with those of intravenous heparin(N=19) and urokinase infusion(N=19). Complete or partial angiographic recanalization of occluded segment was found in 18 patients (67%), and neurologic improvement was followed in 14 patients(52%). The degree of improvement on the stroke scale score after IAUK infusion was statistically more significant(p<0.05) than that shown after intravenous heparin and urokinase infusion. Complications after IAUK infusion were large(15%) and small amount intracerebral hemorrhage(15%), contrast leakage into brain parenchyma(11%), and gastrointestinal bleeding(4%). Between the IAVK and the intravenous urokinase infusion group, differences in extent and types of complications were statistically insignificant, but were significantly higher in those two groups than in the intravenous heparin infusion group. IAUK infusion may be effective for the treatment of acute cerebral stroke

1996-07-01

46

Thrombolytic treatment for acute ischemic cerebral stroke: intraarterial urokinase infusion vs. intravenous heparin and urokinase infusion  

Energy Technology Data Exchange (ETDEWEB)

To evaluate the efficacy and limitation of intra-arterial urokinase (IAUK) infusion for treatment of acute cerebral stroke. Twenty-seven acute cerebral stroke patients treated with IAUK infusion within six hours of stroke onset were reviewed. All patients showed normal initial brain findings on CT. In 21 patients, urokinase(5-15 x 10{sup 5}IU) was administered through a microcatheter placed into or proximal to occluded segment. Mechanical disruption of thrombus by guidewire was performed in 17 patients. Angiographic and clinical responses and complications after IAUK infusion, were evaluated and the results were compared with those of intravenous heparin(N=19) and urokinase infusion(N=19). Complete or partial angiographic recanalization of occluded segment was found in 18 patients (67%), and neurologic improvement was followed in 14 patients(52%). The degree of improvement on the stroke scale score after IAUK infusion was statistically more significant(p<0.05) than that shown after intravenous heparin and urokinase infusion. Complications after IAUK infusion were large(15%) and small amount intracerebral hemorrhage(15%), contrast leakage into brain parenchyma(11%), and gastrointestinal bleeding(4%). Between the IAVK and the intravenous urokinase infusion group, differences in extent and types of complications were statistically insignificant, but were significantly higher in those two groups than in the intravenous heparin infusion group. IAUK infusion may be effective for the treatment of acute cerebral stroke.

Ko, Gi Young; Suh, Dae Chul; Lee, Jae Hong; Kim, Jun Hyoung; Choi, Choong Gon; Lee, Ho Kyu; Lee, Myoung Chong [Ulsan Univ. College of Medicine, Seoul (Korea, Republic of)

1996-07-01

47

Longwall dust control by water infusion  

Energy Technology Data Exchange (ETDEWEB)

Water infusion to reduce the generation of respirable dust during mining is limited in the USA to a few retreating longwall plough faces in the deeper parts of the Pocahontas No. 3 Coalbed. USBM tests in the Lower Sunnyside Coalbed have shown dust reductions of between 47 and 64%. Because water infusion increases the moisture content of the seam, face air velocities in excess of 2.5 m/s are possible before dust entrainment occurs. An economic analysis shows a 23% reduction in operating costs when coal production is increased by changing from unidirectional to bidirectional mining with water infusion.

Cervik, J.

1985-02-01

48

Krypton 81m infusion studies. Chapter 18  

International Nuclear Information System (INIS)

A technique is described to give a continuous, constant-rate, intravascular infusion of "8"1Krsup(m). Modifications of earlier generators included production of sodium-free "8"1Rb, the use of a solution of commercial sterile isotonic non-ionic 5% dextrose-in-water as an eluant, the incorporation of a constant-rate infusion pump, and the miniaturization of the generator column and catheter system. Results are presented of studies of "8"1Krsup(m) distribution in dogs, using both intravenous and intra-arterial infusion. (author)

1978-01-01

49

Pharmacokinetics of morphine infusion in premature neonates.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Morphine pharmacokinetics were studied in 17 premature neonates (26-34 weeks' gestation) after intravenous infusion during the first 24 hours of life. Infants received either standard dose morphine that comprised of a 100 micrograms/kg/hour loading infusion for 2 hours followed by a maintenance infusion of 12.5 micrograms/kg/hour, or a high dose of 200 micrograms/kg/hour for 2 hours followed by 50 micrograms/kg/hour. Mean plasma concentrations of morphine (SD) after 2 and 24 hours were 99 (12...

Hartley, R.; Green, M.; Quinn, M.; Levene, M. I.

1993-01-01

50

Space Tethers Programmatic Infusion Opportunities  

Science.gov (United States)

Programmatic opportunities abound for space Cables, Stringers and Tethers, justified by the tremendous performance advantages that these technologies offer and the rather wide gaps that must be filled by the NASA Exploration program, if the "sustainability goal" is to be met. A definition and characterization of the three categories are presented along with examples. A logical review of exploration requirements shows how each class can be infused throughout the program, from small experimental efforts to large system deployments. The economics of tethers in transportation is considered along with the impact of stringers for structural members. There is an array of synergistic methodologies that interlace their fabrication, implementation and operations. Cables, stringers and tethers can enhance a wide range of other space systems and technologies, including power storage, formation flying, instrumentation, docking mechanisms and long-life space components. The existing tether (i.e., MXER) program's accomplishments are considered consistent with NASA's new vision and can readily conform to requirements-driven technology development.

Bonometti, J. A.; Frame, K. L.

2005-01-01

51

Infusion thrombophlebitis: the histological and clinical features.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Thrombophlebitis was induced in 8 greyhounds by intravenous infusion of naftidrofuryl (Praxilene), dextrose saline being used as a control. The histological features were the same in the treated and the control veins: circulating polymorphonuclear leucocytes became attached to and later infiltrated the vein endothelium. In more severe cases the deeper layers of the vein wall were affected. The clinical features in 97 patients receiving intravenous infusions of physiological saline, dextrose s...

Woodhouse, C. R.

1980-01-01

52

Implantable Micropump Technologies for Murine Intracochlear Infusions  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Due to the very small size of the mouse inner ear, 600 nL volume, developing effective, controlled infusion systems is quite challenging. Key technologies have been created to minimize both size and power for an implantable pump for murine intracochlear infusions. A method for coupling fine capillary tubing to microfluidic channels is presented which provides low volume, biocompatible interconnects withstanding pressures as high as 827 kPa (120 psi) and consuming less than 20 nL of volume exi...

Johnson, D. G.; Waldron, M. J.; Frisina, R. D.; Borkholder, D. A.

2010-01-01

53

The Efficacy of Postoperative Wound Infusion with Bupivacaine for Pain Control after Cesarean Delivery: Randomized Double Blind Clinical Trial  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Objective: This study investigated the efficacy of bupivacaine wound infusion for pain control and opioid sparing effect after cesarean delivery."nMaterials and methods: We conducted a randomized double blind, placebo controlled clinical trial on 60 parturients undergoing cesarean section at a university hospital in Tehran. Patients were randomized to receive a pump infusion system that was filled with either 0.25% bupivacaine or equal volume of distilled water. A catheter was placed abo...

Azin Alavi; Saghar Salehpour; Mahnaz Narimani

2007-01-01

54

Stability and Antibacterial Activity of Cefepime during Continuous Infusion  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The stability of cefepime during simulated continuous infusion was determined with a motorized portable infusion pump worn over a period of 24 to 36 h. Susceptibility testing on cefepime solutions over time indicates that the degradation products do not exhibit antibacterial activity. Cefepime stability at 24 h following continuous infusion was 94.3% ± 1.0%, which supports the use of continuous infusion.

Sprauten, Pa?l F.; Beringer, Paul M.; Louie, Stan G.; Synold, Timothy W.; Gill, Mark A.

2003-01-01

55

A remote drip infusion monitoring system employing Bluetooth.  

Science.gov (United States)

We have developed a remote drip infusion monitoring system for use in hospitals. The system consists of several infusion monitoring devices and a central monitor. The infusion monitoring device employing a Bluetooth module can detect the drip infusion rate and an empty infusion solution bag, and then these data are sent to the central monitor placed at the nurses' station via the Bluetooth. The central monitor receives the data from several infusion monitoring devices and then displays graphically them. Therefore, the developed system can monitor intensively the drip infusion situation of the several patients at the nurses' station. PMID:23366317

Amano, Hikaru; Ogawa, Hidekuni; Maki, Hiromichi; Tsukamoto, Sosuke; Yonezawa, Yoshiharu; Caldwell, W Morton

2012-01-01

56

Subcutaneous insulin infusion: change in basal infusion rate has no immediate effect on insulin absorption rate  

Energy Technology Data Exchange (ETDEWEB)

Eight insulin-dependent diabetic patients were simultaneously given subcutaneous infusions (1.12 IU/h each) of /sup 125/I-labeled Actrapid insulin in each side of the abdominal wall. After 24 h of infusion, the size of the infused insulin depots was measured by external counting for 5 h. The basal infusion rate was then doubled in one side and halved in the other for the next 4 h. Finally, 1.12 IU/h of insulin was given in both sides of the abdominal wall for an additional 3 h. The changes in the size of the depots were measured, and the absorption rates for each hour were calculated. During the first 5 h of infusion, the depot size was almost constant (approximately 5 IU) with an absorption rate that equaled the infusion rate. Doubling the infusion rate led to a significant increase in depot size, but the absorption rate remained unchanged for the first 3 h, and only thereafter was a significant increase seen. When the infusion rate was reduced to the initial 1.12 IU/h, the absorption rate remained elevated during the next 3 h. Correspondingly, when the infusion rate was decreased, the depot size also decreased, but the absorption rate remained unchanged for the first 3 h. The results show that a change in the basal insulin infusion rate does not lead to any immediate change in the insulin absorption rate. This should be considered when planning an insulin-infusion program that includes alteration(s) in the basal-rate setting.

Hildebrandt, P.; Birch, K.; Jensen, B.M.; Kuehl, C.

1986-11-01

57

Subcutaneous insulin infusion: change in basal infusion rate has no immediate effect on insulin absorption rate  

International Nuclear Information System (INIS)

Eight insulin-dependent diabetic patients were simultaneously given subcutaneous infusions (1.12 IU/h each) of "1"2"5I-labeled Actrapid insulin in each side of the abdominal wall. After 24 h of infusion, the size of the infused insulin depots was measured by external counting for 5 h. The basal infusion rate was then doubled in one side and halved in the other for the next 4 h. Finally, 1.12 IU/h of insulin was given in both sides of the abdominal wall for an additional 3 h. The changes in the size of the depots were measured, and the absorption rates for each hour were calculated. During the first 5 h of infusion, the depot size was almost constant (approximately 5 IU) with an absorption rate that equaled the infusion rate. Doubling the infusion rate led to a significant increase in depot size, but the absorption rate remained unchanged for the first 3 h, and only thereafter was a significant increase seen. When the infusion rate was reduced to the initial 1.12 IU/h, the absorption rate remained elevated during the next 3 h. Correspondingly, when the infusion rate was decreased, the depot size also decreased, but the absorption rate remained unchanged for the first 3 h. The results show that a change in the basal insulin infusion rate does not lead to any immediate change in the insulin absorption rate. This should be considered when planning an insulin-infusion program that includes alteration(s) in the basal-rate setting

1986-01-01

58

Pre-rigor infusion with kiwifruit juice improves lamb tenderness.  

Science.gov (United States)

The ability of pre-rigor infusion of kiwifruit juice to improve the tenderness of lamb was investigated. Lamb carcasses were infused (10% body weight) with fresh kiwifruit juice (Ac), water (W) and a non-infusion control (C) treatment. Infusion treatment had no effect on lamb hot carcass weight, cold carcass weight and chilling evaporative losses. The infused treatment carcasses of Ac and W had lower (Pprepared meat tenderizer, which could contribute efficiently and effectively to the meat tenderization process. PMID:20416722

Han, J; Morton, J D; Bekhit, A E D; Sedcole, J R

2009-07-01

59

Decreased flow accuracy from volumetric infusion pumps.  

Science.gov (United States)

Accurate flow from infusion pumps should be maintained when exposed to a variety of clinical conditions. The intent of this study was to evaluate in vitro flow rate accuracy of three infusion pumps subjected to the influences of variable back-pressure, solution viscosity, and infusion rates. A factorial study design was selected to determine the influence of three flow rates (5, 10, and 20 ml/h), three back-pressures (100, 200, and 300 mm Hg), and two solution viscosities (5%, 25% dextrose in water) on flow rate accuracy from three infusion pumps (Abbott 4P, IVAC 560, and Travenol 6200) using a standard gravimetric technique. Mean +/- SD accuracy values were -9.4 +/- 6.4% (range -29.1 to -0.7), 0.5 +/- 2.2% (range -4.2 to 6.3), and -0.5 +/- 4.7% (range -8.5 to 9.9) of the desired rate for the Abbott, IVAC, and Travenol devices, respectively. Back-pressure was the only factor to influence significantly flow accuracy for the Abbott device (r = .81). All factors significantly influenced accuracy for the Travenol device (r = .55). No factor influenced accuracy for the IVAC infusion pump. Both the IVAC 560 and Travenol 6200 have acceptable flow accuracy values within the range of study factors examined. The Abbott 4P had significant decreases in flow accuracy in response to increasing back-pressure. PMID:2766767

Stull, J C; Schneider, P J; Erenberg, A; Leff, R D

1989-09-01

60

Infusion devices: risks and user responsibilities.  

Science.gov (United States)

The Medical Devices Agency of the UK Department of Health continues to receive and investigate reports of incidents that arise from the use of infusion devices. In 1996, the Medical Devices Agency received some 4300 reports of incidents, over 400 of which were classified as infusion-, transfusion-, or dialysis-related. There is, however, a trend towards more active management of medical devices focusing on aspects such as purchasing, training, clinical use, and maintenance, and clearly, nursing staff have an important role in developing such policies. Also, nurses with the responsibility for setting up and overseeing infusions should be aware of some of the problems that can arise during routine use, as an awareness of potential hazards allows users to manage the risks more effectively. This article examines some of the risks associated with the use of infusion devices; in particular, problems that arise while loading the administration set or syringe into the pump, the risks of fluid free flow and syringe siphoning, and the risks from air embolism, flow rate accuracy and infusion pump pressure. PMID:9495951

Morling, S

 
 
 
 
61

PET physiological measurements using constant infusion  

Energy Technology Data Exchange (ETDEWEB)

A wide range of study designs can be used with positron emission tomography methods to provide quantitative measurements of physiological parameters. While bolus injection of tracer is the conventional approach, use of combined bolus plus constant infusion provides a number of advantages for receptor-binding tracers. Of recent interest is the use of this approach to dynamically follow the displacement of tracer during in vivo changes in neurotransmitter concentrations. This paper provides an overview of the tradeoffs in using bolus/infusion methods versus conventional bolus injection for receptor binding studies.

Carson, Richard E. E-mail: richard-e-carson@nih.gov

2000-10-01

62

Intermittent intraarterial infusion chemotherapy for intrapelvic malignancy  

International Nuclear Information System (INIS)

A new modality of topical chemotherapy using intermittent arterial infusion with simultanous occlusion of contralateral feeding artery was performed in 6 patients with intrapelvic malignant tumors (4 prostatic cancer, 1 ovarian cancer and 1 vaginal cancer). The alteration of intrapelvic hemodynamics was achieved by steel coil embolization in the contralateral internal iliac artery via an indwelling infusion tube. After coil embolization, pelvic angiography demonstrated distinct tumor vessels which were not visible before embolization. Furthermore, intensive RI accumulation was found at the site of tumor by scintigram with 99mTc-MAA injected through the infusion tube. In all 4 patients with prostatic cancer, remarkable improvements in symptoms were noted. In two of these patients, a remarkable reduction in tumor size was revealed by Computed Tomogram and sonogram. In the patient with ovarian cancer, tumor size was reduced without pancytopenia which frequently accompanies conventional systemic chemotherapy. These results indicated that this therapy was extremely valuable in the management of intrapelvic malignant tumors, as it allowed concentrated anticancer agents to be selectively infused directly into the tumor feeding vessels without serious side effects. (author)

1987-01-01

63

Intermittent intraarterial infusion chemotherapy for intrapelvic malignancy  

Energy Technology Data Exchange (ETDEWEB)

A new modality of topical chemotherapy using intermittent arterial infusion with simultanous occlusion of contralateral feeding artery was performed in 6 patients with intrapelvic malignant tumors (4 prostatic cancer, 1 ovarian cancer and 1 vaginal cancer). The alteration of intrapelvic hemodynamics was achieved by steel coil embolization in the contralateral internal iliac artery via an indwelling infusion tube. After coil embolization, pelvic angiography demonstrated distinct tumor vessels which were not visible before embolization. Furthermore, intensive RI accumulation was found at the site of tumor by scintigram with /sup 99m/Tc-MAA injected through the infusion tube. In all 4 patients with prostatic cancer, remarkable improvements in symptoms were noted. In two of these patients, a remarkable reduction in tumor size was revealed by Computed Tomogram and sonogram. In the patient with ovarian cancer, tumor size was reduced without pancytopenia which frequently accompanies conventional systemic chemotherapy. These results indicated that this therapy was extremely valuable in the management of intrapelvic malignant tumors, as it allowed concentrated anticancer agents to be selectively infused directly into the tumor feeding vessels without serious side effects.

Nakamura, Kenji; Rin, Mohitsu; Tamaoka, Kouichi and others

1987-07-01

64

Intraventricular infusion of Dopamine in Parkinson's disease.  

Science.gov (United States)

A patient with severe end-stage Parkinson's disease and troublesome fluctuations in motor function was treated with a long-term intraventricular infusion of dopamine. There was modest improvement in speech and mentation and there was smoother control of motor symptoms that was superior to that achieved by conventional oral medications. PMID:2604387

Horne, M K; Butler, E G; Gilligan, B S; Wodak, J; Stark, R J; Brazenor, G A

1989-12-01

65

Low Back Pain During Streptokinase Infusion  

Digital Repository Infrastructure Vision for European Research (DRIVER)

We report the case of a 57-year-old male patient with severe low back pain during streptokinase infusion administered to treat typical chest pain and elevation of the ST segment in the inferior wall. We reviewed the literature, emphasizing the differential diagnosis, the pathophysiology, and management of the event.

Ronald Feitosa Pinheiro; Adriana Sanches Pedrolo; Marcelo Nigri; Antonio Carlos de Camargo Carvalho

2002-01-01

66

The NASA SARP Software Research Infusion Initiative  

Science.gov (United States)

A viewgraph presentation describing the NASA Software Assurance Research Program (SARP) research infusion projects is shown. The topics include: 1) Background/Motivation; 2) Proposal Solicitation Process; 3) Proposal Evaluation Process; 4) Overview of Some Projects to Date; and 5) Lessons Learned.

Hinchey, Mike; Pressburger, Tom; Markosian, Lawrence; Feather, Martin

2006-01-01

67

21 CFR 526.88 - Amoxicillin trihydrate for intramammary infusion.  

Science.gov (United States)

...2010-04-01 2010-04-01 false Amoxicillin trihydrate for intramammary infusion...INTRAMAMMARY DOSAGE FORMS § 526.88 Amoxicillin trihydrate for intramammary infusion... Each single dose syringe contains amoxicillin trihydrate equivalent to 62.5...

2010-04-01

68

Insulin Infusion Set: The Achilles Heel of Continuous Subcutaneous Insulin Infusion  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Continuous subcutaneous insulin infusion from an insulin pump depends on reliable transfer of the pumped insulin to the subcutaneous insulin depot by means of an insulin infusion set (IIS). Despite their widespread use, the published knowledge about IISs and related issues regarding the impact of placement and wear time on insulin absorption/insulin action is relatively small. We also have to acknowledge that our knowledge is limited with regard to how often patients encounter issues with IIS...

Heinemann, Lutz; Krinelke, Lars

2012-01-01

69

Pharmacokinetics and haemodynamic effects of prolonged methohexitone infusion.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

1. The use of continuous infusion anaesthesia has only been of interest since the development of short-acting, less cumulative and less toxic drugs. 2. This study aimed to compare pharmacokinetics and haemodynamic effects during and after long time methohexitone constant rate infusion. Sixteen patients were given either 60 or 90 micrograms kg-1 min-1 methohexitone during 14 h. Blood samples were taken hourly during this time and 12 h following the end of infusion. 3. Infusion period was analy...

Le Normand, Y.; Villepoix, C.; Pinaud, M.; Bernard, J. M.; Fraboul, J. P.; Athouel, A.; Ribeyrol, M.; Beneroso, N.; Larousse, C.

1988-01-01

70

Experiments with wetting agents in coal seam water infusion  

Energy Technology Data Exchange (ETDEWEB)

Coal seam water infusion is an effective dust suppression method. Field tests were conducted with 5 wetting agents in thin seam long-hole water infusion in Hanqiao Colliery, Xuzhou, and the technical parameters for water infusion have been improved at varying degree. Starting from mechanism of wetting agents, the paper describes the lab and site tests with several wetting agents, and the data obtained. Based on comparisons, application of wetting agents in water infusion for dust suppression is preliminarily discussed.

1984-08-01

71

Numerical Simulation Study on the Coal Seam Pulse Water Infusion  

Directory of Open Access Journals (Sweden)

Full Text Available In the process of coal seam pulse water infusion, liquid-solid coupling effect exists in coal seam between the stress field and seepage field. Based on the basic principle of liquid-solid coupling, the dynamic liquid-solid coupling effect of stress and seepage field during coal seam pulse water infusion is simulated through secondary development of ABAQUS software, during this process the mathematical model of the strain accumulation model due to the periodic changes of pulse water pressure is embedded in SOIL module of ABAQUS software. The law of different parameters of pulse water infusion on the permeability of coal around the infusion hole is gotten. Numerical simulation results show that, during the process of coal seam high pressure pulse water infusion, the stress field and flow field are mutual influence and mutual restriction. The coupling of the stress and flow field have impact on the physical and mechanical properties of coal in front of the working face, these factors promote each other and preventing coal and gas outburst effectively. The permeability of coal increase significantly with the water infusion time prolong under constant water infusion pressure and frequency. The permeability of coal increase significantly with the water infusion pressure improving under constant water infusion time and frequency. The permeability of coal increase significantly with the water infusion frequency improving under constant water infusion pressure and time. So the pulse water infusion time needs to ensure a better effect of preventing coal and gas outburst is gotten. Meanwhile the high pressure pulse water infusion pressure needs to improve under the existing technical conditions and not cause big coal fissure. The frequency of pulse water infusion needs to improve under the existing technical conditions. This research results have great theoretical value and practical significance on revealing the mechanism of coal seam pulse water infusion on permeability, enhancing the validity of the technological parameters design in coal seam water infusion and implementing the technology in the site.

Meng Junqing

2014-01-01

72

Accuracy of drug infusion pumps under computer control.  

Science.gov (United States)

Prototype systems implementing algorithms for automated drug infusions are typically constructed by coupling a microcomputer to a drug infusion pump through a serial communications interface. Infusion rates demanded of the infusion pump in many computed-controlled drug delivery applications are made to change at intervals much shorter than those encountered under routine clinical use. Because the ability of infusion pumps to maintain accurate flow rates during high frequency rate changes has not been documented, the purpose of this study was to validate the volumetric accuracy of three commercially available infusion pumps operating in a demanding computer-controlled application. In independent 2-h evaluations, the infusion rate demanded of each pump changed as often as every 5, 10, or 15 s using an algorithm for computer-controlled pharmacokinetic model-driven intravenous infusion. Accuracy of the infusion devices was determined gravimetrically. At all measurement times, each of the infusion pumps was accurate to within approximately +/- 5% of the expected volumetric output under each of the infusion rate intervals tested. Flow rate accuracy of +/- 5% is equal to the nominal expected accuracy of these infusion pumps in conventional clinical use. PMID:1473827

Connor, S B; Quill, T J; Jacobs, J R

1992-09-01

73

Research on wetting agent for water infusion of coal seams  

Energy Technology Data Exchange (ETDEWEB)

Pre-wetting of coal seams by water infusion is an essential measure for dust control at working faces. Adding of wetting agent is an important approach for improving water infusion. This paper discusses the function, effect, optimal concentration, the effect on flotation and selection of wetting agent for coal seam infusion. 2 refs., 11 figs., 10 tabs.

Wang, H.; Wang, Y.; Lu, P. (Huanian Mining Institute (China))

1994-04-01

74

An audit of hospital based outpatient infusions and a pilot program of community-based monoclonal antibody infusions.  

LENUS (Irish Health Repository)

INTRODUCTION: Infliximab, a chimeric monoclonal antibody to tumour necrosis factor alpha, is administered as an intravenous infusion requiring a costly hospital day case or inpatient admission. METHODS: An audit of all current therapies given by intravenous infusions in an outpatient setting in St Vincent\\'s University Hospital (SVUH) was undertaken. Furthermore, in conjunction with TCP homecare, we established in a general practise health clinic, the first Irish community infusion centre for the administration of infliximab in August 2006. RESULTS: All outpatient departments indicated that they would favour a centralized hospital infusion unit. There were no adverse events and the mean global satisfaction improved in the community infliximab infusion pilot programme of seven patients. CONCLUSION: This study suggests efficiencies in providing centralized infusion facilities, while the community based infusion of infliximab is feasible and safe in this small cohort and identifies the community infusion unit as a viable and cost efficient alternative for administration of infliximab.

Doran, J-P

2012-02-01

75

Software Engineering Technology Infusion Within NASA  

Science.gov (United States)

Abstract technology transfer is of crucial concern to both government and industry today. In this paper, several software engineering technologies used within NASA are studied, and the mechanisms, schedules, and efforts at transferring these technologies are investigated. The goals of this study are: 1) to understand the difference between technology transfer (the adoption of a new method by large segments of an industry) as an industry-wide phenomenon and the adoption of a new technology by an individual organization (called technology infusion); and 2) to see if software engineering technology transfer differs from other engineering disciplines. While there is great interest today in developing technology transfer models for industry, it is the technology infusion process that actually causes changes in the current state of the practice.

Zelkowitz, Marvin V.

1996-01-01

76

Epipodophyllotoxin and cisplatin on continuous infusion schedules  

International Nuclear Information System (INIS)

The Epipodophyllotoxins, VP16-213 and VM26, and the heavy metal cytotoxic agents, Cisplatin and its analogs, Spriogermanium and Gallium are discussed as representing classes of agents which in clinical trials are traditionally delivered on an intermittent bolus schedule to coincide with radiation therapy. The continuous infusion of VP16-213 has a strong rationale based upon pharmacokinetic considerations of the drug and schedule dependency in experimental tumor systems. The regional delivery of Cisplatin is examined and has demonstrated some exceptional therapeutic effects, particularly in brain tumors, although toxicity has been substantial. VP16-213 has practical limitations with regard to the infusion schedule relative to the insolubility of the agent in small volumes

1986-01-01

77

[The infusion therapy of the acute bleeding].  

Science.gov (United States)

Intravenous colloid and crystalloid solutions are the mainstay of the acute bleeding therapy. Infusion therapy normalizes the blood circulation volume and improves its flow characteristics. The conducted study revealed that the method normovolemic hemodilution lead to an early unknown type of oxygen insufficiency called the dilutional anemic hypoxia. Authors set up and proved the hypothesis, that decompensated dilutional anemic hypoxia lead to cardiac insufficiency, leading finally to the so called dilutional circulatory hypoxia. PMID:18833153

Bagdasarova, E A; Iarochkin, V S; Chernookov, A I; Bagdasarov, V V; Ramishvili, V Sh

2008-01-01

78

Analysis of the vacuum infusion moulding process  

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This thesis focuses on flow through compliant porous media with applications to the manufacturing of composites by vacuum infusion (VI). The context of this work is the need for reliability in environmentally friendly composite processing methods for composite materials. Commercial reality and the prospective application to low cost structures for the transportation industry dictate that appropriate emphasis should be put on obtaining robust simulations, ensuring reliability and progressing t...

Correia, Nuno Andre? Curado Mateus

2004-01-01

79

Evaluation of Talbot's Safety Zone of Infusion Volume and Osmolality in Infusion Therapy for Decompensated Liver Cirrhosis  

Directory of Open Access Journals (Sweden)

Full Text Available Problems with infusion therapy for correcting fluid and sodium imbalance in decompensated liver cirrhosis (DLC were investigated by establishing the safety zone of Talbot et al. for parenteral fluid therapy in 4 DLC patients infused with over 900 ml of fluid each day for at least 9 days. The safety zone was different in each case. The safe infusion volume decreased and the safe electrolyte concentration shifted to a lower osmolality when there was ascites with renal failure than ascites without renal failure. Infusion therapy was performed without deterioration of the water and sodium balance in those patients whose infusion volume and fluid osmolality were in the safety zone. In contrast, ascites retention increased and peripheral edema appeared in patients whose infusion volume and osmolality were out of the safety zone. Therefore, the safety zone should be determined repeatedly during infusion therapy.

Yuasa,Shiro

1985-06-01

80

Kiovig for primary immunodeficiency: reduced infusion and decreased costs per infusion.  

Science.gov (United States)

Kiovig is a ready-to-use 10% liquid immunoglobulin preparation that is medically indicated for the treatment of primary immunodeficiency. This study aims to conduct an economic evaluation which compares the intravenous immunoglobulin (IVIg) preparations Kiovig, Multigam, and Sandoglobulin from the Belgian societal perspective. As three prospective studies have observed no difference in outcomes, a cost-minimization analysis is considered appropriate to evaluate differences in treatment costs that can arise from IVIgs. A decision-analytic model simulated treatment costs attributed to one infusion. Resource use data were derived from a Dutch costing study. Cost items included immunoglobulin costs, pharmacy administration and nursing costs, mini-forfait for hospital infusion, costs of adverse events, and lost productivity with 2009 as base year. Cost data were identified from published sources and Belgian hospital administrators. A probabilistic sensitivity analysis explored the impact of parameter uncertainty on cost results. Costs per infusion cycle in adult primary immunodeficiency patients were €1,046 (95% confidence interval: €1,006-1,093) with Kiovig; €1,102 (€1,064-1,147) with Multigam; and €1,147 (€1,108-1,193) with Sandoglobulin. The average cost savings per infusion with Kiovig as compared to Multigam and Sandoglobulin amounted to €56 and €101 per infusion. In conclusion, treatment costs with Kiovig were shown to be lower as compared to other IVIgs in Belgium. Reduced costs per infusion were attributed to lower costs associated with treating adverse events and the opportunity cost of nursing time and time off work for working adults. PMID:21570491

Connolly, Mark; Simoens, Steven

2011-09-01

 
 
 
 
81

Implantable, remotely-programmable insulin infusion system  

Energy Technology Data Exchange (ETDEWEB)

An implantable, remotely-programmable insulin infusion system is described which has a mass of 280 grams and an implanted lifetime exceeding two years. The system uses a rotary solenoid-driven peristaltic pump controlled by low power CMOS timing circuitry which provides bimodal insulin delivery. Fifteen low rates from 0.39 to 5.9 units/hour and 15 high doses from 0.84 to 12.5 units are available using U100 insulin. The system has been tested in the laboratory, evaluated in diabetic dogs, and implanted in one diabetic human.

Carlson, G.A.; Bair, R.E.; Gaona, J.I. Jr.; Love, J.T.; Urenda, R.S.

1981-10-01

82

Rat enterohepatic circulation and intestinal distribution of enterally infused thyroid hormones  

International Nuclear Information System (INIS)

The enterohepatic circulation (recycling), intestinal (gut) distribution, metabolism, and excretion of enterally infused thyroid hormones were studied in the intact rat under approximately normal physiological steady state conditions. Rats with 7-day osmotic minipumps implanted ip received constant intraduodenal infusions to steady state of very small trace doses of either 125I-labeled T3 (T3*) or T4 (T4*). Enterohepatic and other pathways remained open to normal function, and in particular, there was no biliary diversion or ligation. Complete feces and urine were collected daily, to assess daily distributions of radioactivity and establishment of the steady state, which occurred by day 3. On day 7, rats were anesthetized, blood was sampled, whole intestine and minipumps were removed, and the gut was separated into six segments. Fecal samples and the contents of each gut section were homogenized, ethanol extracted, evaporated, and reconstituted in NaOH for quantitative aqueous chromatography along with infusate, urine, and plasma samples, on Sephadex G-25 columns. No T3* or T4* was found in urine, but feces contained 39% of the T3* infused and 36% of the T4* infused in steady state. Statistically significant amounts of both T3* and T4* in systemic plasma on day 7 clearly indicated absorption of the hormones from the intestine, distinctly demonstrating an enterohepatic circulation of T3 and T4 under experimental conditions closely approximating the physiological steady state. This also establishes the intestine (with its contents) as an exchangeable hormone pool, physiologically internal to the system regulating thyroid hormones and their distribution. Gut contents contained 52 times more T3* and 4.34 times more T4* than corresponding plasma pools in steady state

1988-01-01

83

INTRAVENOUS FENTANYL INFUSION AS AN ANALAGESIC AGENTS FOR LABOR PAIN  

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Introduction. There are few studies about intravenous fentanyl infusion for reduce labor pain. This study evaluate the usefulness of intravenous fentanyl infusion for labor analgesia. Methods. Seventy seven healthy pregnant women were randomized to recive 1.5-2.5µg/kg/hr intravenous fentanyl infusion (interventional group) or placebo (control group). Maternal labor pain intensity, systolic, diastolic and mean arterial blood pressure, pulse and respiratory rate, frequency of nausea and v...

Soltani Nezhad, H.; SH ARAM; Monajjemi, Z.; Jaafar-zadeh, L.

2001-01-01

84

Clinical applications of continuous infusion chemotherapy ahd concomitant radiation therapy  

Energy Technology Data Exchange (ETDEWEB)

This book presents information on the following topics: theoretical basis and clinical applications of 5-FU as a radiosensitizer; treatment of hepatic metastases from gastro intestingal primaries with split course radiation therapy; combined modality therapy with 5-FU, Mitomycin-C and radiation therapy for sqamous cell cancers; treatment of bladder carcinoma with concomitant infusion chemotherapy and irradiation; a treatment of invasiv bladder cancer by the XRT/5FU protocol; concomitant radiation therapy and doxorubicin by continuous infusion in advanced malignancies; cis platin by continuous infusion with concurrent radiation therapy in malignant tumors; combination of radiation with concomitant continuous adriamycin infusion in a patient with partially excised pleomorphic soft tissue sarcoma of the lower extremeity; treatment of recurrent carcinoma of the paranasal sinuses using concomitant infusion cis-platinum and radiation therapy; hepatic artery infusion for hepatic metastases in combination with hepatic resection and hepatic radiation; study of simultaneous radiation therapy, continuous infusion, 5FU and bolus mitomycin-C; cancer of the esophagus; continuous infusion VP-16, bolus cis-platinum and simultaneous radiation therapy as salvage therapy in small cell bronchogenic carcinoma; and concomitant radiation, mitomycin-C and 5-FU infusion in gastro intestinal cancer.

Rosenthal, C.J.; Rotman, M.

1986-01-01

85

Clinical applications of continuous infusion chemotherapy ahd concomitant radiation therapy  

International Nuclear Information System (INIS)

This book presents information on the following topics: theoretical basis and clinical applications of 5-FU as a radiosensitizer; treatment of hepatic metastases from gastro intestingal primaries with split course radiation therapy; combined modality therapy with 5-FU, Mitomycin-C and radiation therapy for sqamous cell cancers; treatment of bladder carcinoma with concomitant infusion chemotherapy and irradiation; a treatment of invasiv bladder cancer by the XRT/5FU protocol; concomitant radiation therapy and doxorubicin by continuous infusion in advanced malignancies; cis platin by continuous infusion with concurrent radiation therapy in malignant tumors; combination of radiation with concomitant continuous adriamycin infusion in a patient with partially excised pleomorphic soft tissue sarcoma of the lower extremeity; treatment of recurrent carcinoma of the paranasal sinuses using concomitant infusion cis-platinum and radiation therapy; hepatic artery infusion for hepatic metastases in combination with hepatic resection and hepatic radiation; study of simultaneous radiation therapy, continuous infusion, 5FU and bolus mitomycin-C; cancer of the esophagus; continuous infusion VP-16, bolus cis-platinum and simultaneous radiation therapy as salvage therapy in small cell bronchogenic carcinoma; and concomitant radiation, mitomycin-C and 5-FU infusion in gastro intestinal cancer

1986-11-12

86

Pulsatile versus steady infusions for hepatic artery chemotherapy  

International Nuclear Information System (INIS)

Hepatic artery chemotherapy for unresectable liver tumors requires an even distribution of the drugs in the tumor or vascular bed. This cannot be determined angiographically because the drugs are infused at a much lower rate than the contrast media. It is easy, however, to determine the quality of the perfusion by injecting a small volume of Tc-99m MAA in one of the side ports while chemotherapeutic agent is being infused at the same rate. Usually this shows a uniform, satisfactory distribution of isotope. Occasionally, however, some areas fail to receive Tc-99m in spite of what appears to be a good position of the catheter tip. Since ''streaming'' of the infused drugs has been blamed for their uneven distribution, the authors decided to compare the usual steady flow infusions with infusions made pulsatile by the addition of a pulsing device (Gianturco Pump) attached to the infusion tubing. Eighty-three patients were studied with steady as well as pulsatile infusions. In 16 of these patients the perfusion pattern was definitely changed by the pulsatile infusion. In one patient the pulsatile mode resulted in an unwanted gastric perfusion. In 5 patients the distribution was improved in one hepatic lobe and in 10 patients it was improved in both lobes. These results show that hepatic artery perfusions can occasionally be improved by pulsing the infusate. However, pulsing can produce the unwanted perfusion of extra-hepatic areas

1984-06-05

87

Adenosine infusion increases plasma levels of VEGF in humans  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Many in vitro studies have shown that adenosine (Ado can induce vascular endothelial growth factor (VEGF mRNA and protein expression and stimulate endothelial proliferation. In the present study, we seek to determine whether Ado can increase circulating levels of VEGF protein in the intact human. Methods Five outpatients 49.3 ± 6.7 years of age and weighing 88.2 ± 8.5 kg were selected. They were given a 6 min intravenous infusion of Ado (0.14 mg kg-1 min-1 in conjunction with sestamibi myocardial perfusion scans. Mean blood pressure (MBP, calculated from systolic and diastolic values and heart rate (HR were determined before Ado infusion and every 2 min for the next 10 min. Plasma VEGF concentrations (ELISA were determined immediately before Ado infusion and 1 h, 2 h, and 8 h after the infusion. Results Plasma VEGF concentration averaged 20.3 ± 2.0 pg ml-1 prior to Ado infusion, and increased to 62.7 ± 18.1 pg ml-1 at 1 h post- infusion (p -1. MBP averaged 116 ± 7 mmHg and heart rate averaged 70 ± 7 prior to Ado infusion. MBP decreased by a maximum of ~22% and HR increased by a maximum of ~17% during the infusion. Conclusion We conclude from these preliminary findings that intravenous infusion of adenosine can increase plasma levels of VEGF in humans.

Pryor Janelle S

2005-06-01

88

Is pancreatitis a complication of propofol infusion?  

Science.gov (United States)

The effects of bolus and infusion doses of propofol on histopathological changes in the rat pancreas are reported. After obtaining Hospital Ethics Committee approval, 75 female Wistar rats were assigned to three study groups. Groups I (n = 30) and II (n = 30) received 10 mg kg-1 intravenous bolus of propofol; with propofol administered to group II at an infusion rate of 10 mg kg-1 h-1 for 30 min immediately after the bolus doses. Group III (n = 15) was used as the control group. Twenty-four hours after propofol administration blood samples and pancreatic tissue specimens were obtained under ether anaesthesia. Plasma cholesterol, triglyceride, amylase, and lipase levels were studied, and pancreatic tissues were examined under light microscopy. Plasma cholesterol and triglyceride levels were significantly higher in group II compared with the other groups. Differences between the groups in respect of plasma amylase and lipase levels were not statistically significant. Acute pancreatitis was observed under light microscopy, in three rats (10%) in group II, and in one rat (6.6%) in the control group. The pancreatic tissues of group I were normal. The incidence of acute pancreatitis in each of the groups was not significant. It is therefore suggested that, further controlled studies are needed to investigate the relation between pancreatitis and the use of propofol. PMID:10434163

Dönmez, A; Arslan, G; Pirat, A; Demirhan, B

1999-06-01

89

Reassessment of external insulin infusion pumps.  

Science.gov (United States)

Continuous subcutaneous insulin infusion (CSII) therapy using external infusion pumps provides an alternative to multiple daily injections (MDI) for insulin-dependent diabetics who require intensive insulin therapy. CSII allows for the delivery of regular insulin continuously at preset basal rates and at bolus doses, which can be varied in response to insulin needs of the patient. Intensive insulin therapy by CSII or MDI was administered to diabetics to improve control of their blood glucose levels and to assess its effects on the development of complications such as retinopathy and nephropathy. CSII appeared to be as effective as MDI in attaining near-normoglycemia and improving metabolic control in patients with insulin-dependent diabetes mellitus who required intensive insulin therapy. It was not clear, however, whether the improved control of the blood glucose levels resulted in the prevention or progression of the diabetic complications. The risks of having adverse effects, such as diabetic ketoacidosis or hypoglycemia, were higher with CSII as compared with MDI; both methods having higher risks of these complications in comparison to conventional insulin therapy. CSII may be beneficial for patients requiring intensive insulin therapy who may need greater lifestyle flexibility with regard to meal timing, work, and recreational scheduling. PMID:2129578

Hotta, S S; Adams, D

1990-01-01

90

Evaluation of Talbot's Safety Zone of Infusion Volume and Osmolality in Infusion Therapy for Decompensated Liver Cirrhosis  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Problems with infusion therapy for correcting fluid and sodium imbalance in decompensated liver cirrhosis (DLC) were investigated by establishing the safety zone of Talbot et al. for parenteral fluid therapy in 4 DLC patients infused with over 900 ml of fluid each day for at least 9 days. The safety zone was different in each case. The safe infusion volume decreased and the safe electrolyte concentration shifted to a lower osmolality when there was ascites with renal failure than ascites w...

Yuasa, Shiro; Itoshima, Tatsuya; Ono, Ryosaku; Nagashima, Hideo

1985-01-01

91

A comparison of three different target-controlled remifentanil infusion rates during target-controlled propofol infusion for oocyte retrieval  

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OBJECTIVE: To evaluate the effects of three different target-controlled remifentanil infusion rates during target-controlled propofol infusion on hemodynamic parameters, pain, sedation, and recovery score during oocyte retrieval. METHODS: Sixty-nine women were scheduled for oocyte retrieval. Target-controlled propofol infusion at an effectsite concentration of 1.5 ?g/mL was instituted. The patients were randomly allocated to receive remifentanil at an effect-site concentration of either ...

Demet Coskun; Berrin Gunaydin; Ayca Tas; Gozde Inan; Hulya Celebi; Kadir Kaya

2011-01-01

92

RF tumor ablation with internally cooled electrodes and saline infusion: what is the optimal location of the saline infusion?  

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Abstract Background Radiofrequency ablation (RFA) of tumors by means of internally cooled electrodes (ICE) combined with interstitial infusion of saline may improve clinical results. To date, infusion has been conducted through outlets placed on the surface of the cooled electrode. However, the effect of infusion at a distance from the electrode surface is unknown. Our aim was to assess the effect of perfusion distance (PD) on the coagulation geometry and deposited power duri...

2007-01-01

93

Experimental study on intra-arterial infusion of basic fibroblast growth factor in the ischemic limbs of rabbit model  

International Nuclear Information System (INIS)

Objective: To evaluate the effect of intra-arterial infusion of basic fibroblast growth factor (bFGF) on improving neovascularization, vascular perfusion and the function of partially ischemic limbs of rabbits. Methods: Twenty-seven New Zealand male rabbits were selected. Partial ischemia model was induced by surgical ligation of the primary branches of right femoral artery in each animal, and the left hind limb of each animal was served as a nonischemic control. Then, 27 rabbits were randomly assigned to three groups: intra-arterial (IA) infusion of bFGF (n=9), intravenous (IV) infusion of bFGF and IA infusion of saline (n=9). Infusion was separately performed immediately after vascular ligation, 8th and 15th days post-surgery with 10 ?g (4 ml) of bFGF per-time (or the same volume of saline). The differences between three groups and between ischemic and nonischemic limbs of the same group were compared and evaluated by the following indexes: (1) vessel section count (VSC), vessel section surface area (VSS) and vessel section perimeter (VSP) in the field of ischemic muscle tissues taken at 22nd day postoperatively; (2) capillary refilling time of ischemic limbs; and (3) functional and trophic changes of ischemic limbs. Statistical differences were evaluated by one-way ANOVA and T test. Results: VSC, VSS and VSP of the IA-bFGF group were significantly increased than those of the IV-bFGF and IA-saline groups (P<0.01). At 22nd day postoperatively, the capillary refilling time, new hair growth, the appearance and function of all ischemic limbs in IA-bFGF group were approximately normal. However, in IA-saline group, the ischemic changes, capillary refilling time and the function of ischemic limbs were not improved significantly. All the indexes of IV-bFGF group showed no difference statistically from those of IA-saline group. Conclusions: This experimental study identifies that intra-arterial infusion of bFGF may significantly promote neovascularization and vascular perfusion in ischemic limbs, suggesting that a better effect may be obtained with IA-infusion bFGF than that of IV-infusion bFGF. (authors)

2005-02-01

94

Evaluation of platelet deposition at local thrombophlebitis, caused by intravenous infusion of anticancer drug (Bisantrene), with In-111-platelets in rabbits  

Energy Technology Data Exchange (ETDEWEB)

Several anticancer drugs produce localized thrombophlebitis (LTP) when infused intravenously and LTP is the dose-limiting factor. LTP was studied in New Zealand albino rabbits by I.V. infusion of Bisantrene (BS: approx. = 40 mg/rabbit, six rabbits via ear veins, five via jugular veins, two control, 0.9% saline). Radioactivity in three sections of each harvested vein was determined with a gamma counter, and the ratio of radioactivity per mg of infused vein and control vein was determined and the results are presented in this paper. Scanning electron micrograph of BS-infused vein lumen revealed plaques of amorphous material (BS) and adherent platelet thrombus. Platelet deposition at BS-induced LTP in jugular and ear veins reached a maximum at four to eight hours. Thus, LTP could be imaged and quantified with In-111-labeled platelets.

Dewanjee, M.K.; Powis, G.; Chowdhury, S.

1985-05-01

95

Evaluation of platelet deposition at local thrombophlebitis, caused by intravenous infusion of anticancer drug (Bisantrene), with In-111-platelets in rabbits  

International Nuclear Information System (INIS)

Several anticancer drugs produce localized thrombophlebitis (LTP) when infused intravenously and LTP is the dose-limiting factor. LTP was studied in New Zealand albino rabbits by I.V. infusion of Bisantrene (BS: ? 40 mg/rabbit, six rabbits via ear veins, five via jugular veins, two control, 0.9% saline). Radioactivity in three sections of each harvested vein was determined with a gamma counter, and the ratio of radioactivity per mg of infused vein and control vein was determined and the results are presented in this paper. Scanning electron micrograph of BS-infused vein lumen revealed plaques of amorphous material (BS) and adherent platelet thrombus. Platelet deposition at BS-induced LTP in jugular and ear veins reached a maximum at four to eight hours. Thus, LTP could be imaged and quantified with In-111-labeled platelets

1985-05-01

96

Acute renal artery occlusion following infliximab infusion.  

Science.gov (United States)

We report the case of a 44-year-old male patient who presented with acute renal artery occlusion, 3 d after first injection of infliximab for steroid refractory attack of ulcerative colitis. Extensive work-up provided no evidence of predisposing factors for arterial thrombosis. Infliximab was thus suspected in the genesis of thrombosis, based on both intrinsic and extrinsic criteria. At month 3 after thrombosis with ongoing anticoagulation, angio-tomodensitometry showed complete revascularization of the left renal artery with renal atrophy. Renal function remained normal and the patient was still in steroid free remission on mercaptopurin monotherapy at maximal follow-up. Few thromboembolic events have been described with anti- tumor necrosis factor (TNF) agents, but it is the first case reported of renal artery thrombosis after infliximab infusion. In addition, we review thrombosis associated with anti-TNF agents. PMID:24255891

Lemaitre, Caroline; Iwanicki-Caron, Isabelle; Vecchi, Clément De; Bertiaux-Vandaële, Nathalie; Savoye, Guillaume

2013-08-01

97

Inhibition of endogenous lactate turnover with lactate infusion in humans  

Energy Technology Data Exchange (ETDEWEB)

The extent to which lactate infusion may inhibit endogenous lactate production, though previously considered, has never been critically assessed. To examine this proposition, single injection tracer methodology (U-{sup 14}C Lactate) has been used for the estimation of lactate kinetics in 12 human subjects under basal conditions and with the infusion of sodium lactate. The basal rate of lactate turnover was measured on a day before the study with lactate infusion, and averaged 63.7 + 5.5 mg/kg/h. Six of these individuals received a stable lactate infusion at an approximate rate of 160 mg/kg/h, while the remaining six individuals were infused at the approximate rate of 100 mg/kg/h. It has been found that stable lactate infused at rates approximating 160 mg/kg/h consistently produced a complete inhibition of endogenous lactate production. Infusion of lactate at 100 mg/kg/h caused a lesser and more variable inhibition of endogenous lactate production (12% to 64%). In conclusion, lactate infusion significantly inhibits endogenous lactate production.

Searle, G.L.; Feingold, K.R.; Hsu, F.S.; Clark, O.H.; Gertz, E.W.; Stanley, W.C. (Veterans Administration Medical Center, San Francisco, CA (USA))

1989-11-01

98

Perisciatic infusion of ropivacaine and analgesia after hallux valgus repair  

DEFF Research Database (Denmark)

Moderate to severe pain after hallux valgus repair can be successfully treated with a continuous popliteal sciatic nerve block in ambulatory patients. Different anesthesiologists use various infusion rates for this purpose. The aim of this study was to compare the analgesic efficacy of two infusion rates of ropivacaine 2 mg/ml: 5 and 8 ml/h.

Zaric, D; Jørgensen, B G

2010-01-01

99

Brain activity following esophageal acid infusion using positron emission tomography  

Directory of Open Access Journals (Sweden)

Full Text Available AIM: To investigate symptoms and brain activity following esophageal acid infusion.METHODS: Fifteen healthy volunteers were recruited for the study. Hydrochloric acid (pH 1 and 2 and distilled water (pH 7 were randomly and repeatedly infused into the esophagus. The brain activity was evaluated by positron emission tomography. The severity of heartburn elicited by the infusion was rated on an auditory analog scale of 0-10.RESULTS: The severity of heartburn following each infusion showed a step-wise increase with increasing acidity of the perfusate. The heartburn scores were significantly higher in the second pH 1 infusion compared with the first infusion. Acid and distilled water infusion induced activation of various brain areas such as the anterior insula, temporal gyrus, and anterior/posterior cingulate cortex. At pH 1 or 2, in particular, activation was observed in some emotion-related brain areas such as the more anterior part of the anterior cingulate cortex, parahippocampal gyrus, or the temporal pole. Strong activation of the orbitofrontal cortex was found by subtraction analysis of the two second pH 1 infusions, with a significant increase of heartburn symptoms.CONCLUSION: Emotion-related brain areas were activated by esophageal acid stimulation. The orbitofrontal area might be involved in symptom processing, with esophageal sensitization induced by repeated acid stimulation.

Shigeyuki Kobayashi, Yasuhiko Abe, Manabu Tashiro, Tomoyuki Koike, Katsunori Iijima, Akira Imatani, Shuichi Ohara, Satoshi Watanabe, Shin Fukudo, Tooru Shimosegawa

2010-11-01

100

Infusion of mature megakaryocytes into mice yields functional platelets  

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Thrombopoiesis, the process by which circulating platelets arise from megakaryocytes, remains incompletely understood. Prior studies suggest that megakaryocytes shed platelets in the pulmonary vasculature. To better understand thrombopoiesis and to develop a potential platelet transfusion strategy that is not dependent upon donors, of which there remains a shortage, we examined whether megakaryocytes infused into mice shed platelets. Infused megakaryocytes led to clinically relevant increases...

Fuentes, Rudy; Wang, Yuhuan; Hirsch, Jessica; Wang, Cheng; Rauova, Lubica; Worthen, G. Scott; Kowalska, M. Anna; Poncz, Mortimer

2010-01-01

 
 
 
 
101

Longwall dust control potentially enhanced by surface borehole water infusion  

Energy Technology Data Exchange (ETDEWEB)

Injecting water under pressure to wet the coalbed in advance of mining reduces mining-generated respirable dust. Owing to economic and geological barriers, water infusion for longwall dust control in the United States is currently limited to the Pocahontas No. 3 Coalbed in Virginia. Water is pumped into the coalbed through underground boreholes drilled horizontally from the headgate toward the tailgate side of retreat longwall panels. This paper theorizes that the barriers to widespread utilization of water infusion for longwall dust control could be overcome by long-duration, low-pressure water infusion through vertical gob gas boreholes. Currently, 43% of the 72 longwall mines in the United States employ vertical gob gas boreholes. Computer coalbed reservoir simulation suggests that one vertical surface borehole could infuse the same longwall panel area as four horizontal boreholes in the current water infusion system for longwall dust control in the Pocahontas No. 3 Coalbed.

Campoli, A.A.; McCall, F.E.; Finfinger, G.L. [Bureau of Mines, Pittsburgh, PA (United States); Zuber, M.D. [S.A. Holditch and Associates, Inc., Pittsburgh, PA (United States)

1995-12-31

102

Accelerated infliximab infusions for inflammatory bowel disease improve effectiveness  

Directory of Open Access Journals (Sweden)

Full Text Available AIM: To study the safety and effectiveness associated with accelerated infliximab infusion protocols in patients with inflammatory bowel disease (IBD. METHODS: Original protocols and infusion rates were developed for the administration of infliximab over 90-min and 60-min. Then the IBD patients on stable maintenance infliximab therapy were offered accelerated infusions. To be eligible for the study, patients needed a minimum of four prior infusions. An initial infusion of 90-min was given to each patient; those tolerating the accelerated infusion were transitioned to a 60-min infusion protocol at their next and all subsequent visits. Any patient having significant infusion reactions would be reverted to the standard 120-min protocol. A change in a patient’s dose mandated a single 120-min infusion before accelerated infusions could be administered again. RESULTS: The University of Virginia Medical Center's Institutional Review Board approved this study. Fifty IBD patients treated with infliximab 5 mg/kg, 7.5 mg/kg and 10 mg/kg were offered accelerated infusions. Forty-six patients consented to participate in the study. Nineteen (41.3% were female, five (10.9% were African American and nine (19.6% had ulcerative colitis. The mean age was 42.6 years old. Patients under age 18 were excluded. Ten patients used immunosuppressive drugs concurrently out of which six were taking azathioprine, three were taking 6-mercaptopurine and one was taking methotrexate. One of the 46 study patients used corticosteroid therapy for his IBD. Seventeen of the patients used prophylactic medications prior to receiving infusions; six patients received corticosteroids as pre-medication. Four patients had a history of distant transfusion reactions to infliximab. These reactions included shortness of breath, chest tightness, flushing, pruritus and urticaria. These patients all took prophylactic medications before receiving infusions. 46 patients (27 males and 19 females received a total of fifty 90-min infusions and ninety-three 60-min infusions. No infusion reactions were reported. There were no adverse events, including drug-related infections. None of the patients developed cancer of any type during the study timeframe. Total cost savings for administration of the both 90-min and 60-min accelerated infusions compared to standard 120-min infusions was estimated to be $53?632 ($116?965 vs $63?333, P = 0.001. One hundred and eighteen hours were saved in the administration of the accelerated infusions (17?160 min vs 10?080 min, P = 0.001. In the study population, overweight females [body mass index (BMI > 25.00 kg/m2] were found to have statistically higher BMIs than overweight males (mean BMI 35.07 ± 2.66 kg/m2 vs 30.08 ± 0.99 kg/m2, P = 0.05, finding which is of significance since obesity was described as being one of the risk factors for Crohn’s disease. CONCLUSION: We are the first US group to report substantial cost savings, increased safety and patient satisfaction associated with accelerated infliximab infusion.

John McConnell

2012-01-01

103

Evaluation of maternal infusion therapy during pregnancy for fetal development  

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Full Text Available The aim of this project was to study the possible association between maternal infusion treatments during pregnancy and variables of fetal development as well as the occurrence of congenital abnormalities (CA in a case-control design. The large population-based data set of the Hungarian Case?Control Surveillance of Congenital Abnormalities (HCCSCA was evaluated based on the medically recorded infusion treatment during pregnancy. Of 22,843 case pregnant women who had newborns or fetuses with congenital abnormalities, 112 (0.5%, while of 38,151 control pregnant women who had newborn infants without any defects, 262 (0.7%, had infusion treatment during pregnancy. Infusion treatment was more frequent in the control group than in the case group with congenital abnormalities (adjusted POR with 945 95% CI: 0.7, 0.6-0.9 and there was no higher rate of maternal infusion treatments in any congenital abnormality group. Mean gestational age was shorter and mean birth weight was smaller in control newborn infants without CA born to mothers with infusion treatment during pregnancy than in the babies of mothers without infusion treatment. The prevalence of mild intrauterine growth retardation was more frequent in the fetuses of pregnant women with hyperemesis gravidarum treated with infusion. The results of the study suggest that infusion treatment of pregnant women did not associate with a higher risk of congenital abnormalities. In addition, the intravenous infusion of drugs has some, but limited efficacy to prevent the adverse effects of hyperemesis gravidarum and threatened preterm delivery.

2005-10-01

104

Early mechanism of action of arterially infused ethanol: an experimental study on the influence of infusion speed  

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Abdominal aortography and histopathologic examination after absolute ethanol infusion at fast (0.4cc/sec) and slow speed (0.04cc/sec) were performed on 16 rats (2 controls. 7 fast infusion group. 7 slow infusion group). Angiographic and histopathologic findings were correlated and the findings of slow and fast infusion groups were studied. The results are as follows: 1. Histopathologic findings of the fast infusion group revealed wide area of glomerular and tubular collapses, obliteration of the free space between the Bowmann's capsule and glomerulus, sloughing and loss of the endothelium, fresh thrombi attached to the wall, and cleavage of the muscle layer of the arteries. 2. Angiographic findings of the fast infusion group revealed luminal irregularity, early obstruction of the aorta and the renal arteries, and delayed circulation time. 3. Histopathologic findings of the slow infusion group revealed degenerated, coalesced red blood cell packed in the glomeruli, focal areas of severe glomerular and tubular damage on relatively normal background, endothelial and muscular damage of the arteries. 4. Angiographic findings of the slow infusion group revealed focal perfusion defect of the kidney, delayed circulation time, and mild luminal irregularity, but there was no obstruction of the major arteries. 5. In conclusion, author believes that endothelial damage and thrombus formation from the damaged vessel wall, as well as direct cytotoxicity and in situ emboli formation play a significant role in the embolic effect of absolute ethanol.

Han, Joon Koo [Seoul District Armed Force General Hospital, Seoul (Korea, Republic of)

1988-12-15

105

Early mechanism of action of arterially infused ethanol: an experimental study on the influence of infusion speed  

International Nuclear Information System (INIS)

Abdominal aortography and histopathologic examination after absolute ethanol infusion at fast (0.4cc/sec) and slow speed (0.04cc/sec) were performed on 16 rats (2 controls. 7 fast infusion group. 7 slow infusion group). Angiographic and histopathologic findings were correlated and the findings of slow and fast infusion groups were studied. The results are as follows: 1. Histopathologic findings of the fast infusion group revealed wide area of glomerular and tubular collapses, obliteration of the free space between the Bowmann's capsule and glomerulus, sloughing and loss of the endothelium, fresh thrombi attached to the wall, and cleavage of the muscle layer of the arteries. 2. Angiographic findings of the fast infusion group revealed luminal irregularity, early obstruction of the aorta and the renal arteries, and delayed circulation time. 3. Histopathologic findings of the slow infusion group revealed degenerated, coalesced red blood cell packed in the glomeruli, focal areas of severe glomerular and tubular damage on relatively normal background, endothelial and muscular damage of the arteries. 4. Angiographic findings of the slow infusion group revealed focal perfusion defect of the kidney, delayed circulation time, and mild luminal irregularity, but there was no obstruction of the major arteries. 5. In conclusion, author believes that endothelial damage and thrombus formation from the damaged vessel wall, as well as direct cytotoxicity and in situ emboli formation play a significant role in the embolic effect of absolute ethanol.

1988-12-01

106

Redistribution of arterial blood flow in metastases-bearing livers after infusion of degradable starch microspheres.  

Science.gov (United States)

Changes in intrahepatic arterial blood flow after intraarterial injection of degradable starch microspheres (DSM) were studied in four patients undergoing hepatic arterial chemotherapy. All four livers contained metastases, three from colorectal cancer and one from melanoma. Using a CT scanner with a dynamic program, 8 mm liver sections were studied in each patient before and after the DSM infusion (180(-6) in 3 min). Density plots were obtained from 12 tumoral and 12 parenchymal areas after 5 ml push arterial injections of nonionic contrast medium. The areas under the curves (ID) were calculated. The ID after DSM infusion was reduced by 94% in a single hyperdense colorectal metastasis and by a mean of c. 82% in ten parenchymal areas. By contrast, nine hypodense colorectal metastases showed an average ID decrease of c. 156%. The ID of two melanoma metastases was reduced after DSM (-48% and -68%), while the ID of two matched parenchymal areas showed an approximately similar degree of increase (+36% and +64%). Since ID after contrast injection can be assumed to be a function of blood volume, mutual changes of parenchymal and tumoral blood flow appear to take place in metastases-bearing liver after arterial infusion of DSM. This phenomenon may be of diagnostic and therapeutic value for intraarterial chemotherapy of liver tumors. PMID:4090888

Civalleri, D; Rollandi, G; Simoni, G; Mallarini, G; Repetto, M; Bonalumi, U

1985-01-01

107

Intraarterial infusion chemotherapy for the treatment of metastatic liver cancer  

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Some techniques of the most recent interventional radiology are very useful for the treatment of metastatic liver cancer and changing the style of hepatic infusion chemotherapy. This report shows our latest results and methods of hepatic infusion chemotherapy for metastatic liver cancer. 1. For the catheter placement, a new catheterization route via the left subclavian artery into the hepatic artery was developed and performed in 132 cases. Superselective catheterization succeeded in 123 cases (93.2%). This procedure is less invasive than laparotomy and less troublesome than other percutaneous routes. 2. For useful infusion system, an implantable injection port ''Reservoir'' was developed and it was used in 87 cases. This method makes arterial infusion chemotherapy easy, and imploves their quality of life. 3. To acquire adequate drug delivery, arterial redistribution by steel coils was done, and 109 arteries in 80 cases were occluded. This method is very useful to make multiple hepatic artery single and it is important to avoid gasroduodenal complications. 4. Now, using these techniques, the phase II study of 5FU, ADM, MMC combined hepatic infusion in patients with non-resectable metastatic liver cancer is done. Up to this time, such a phase study on arterial infusion chemotherapy was difficult because of technical problems, but these new techniques make it possible. In conclusion, these new methods change the style and conception of hepatic infusion, and these make much progress on the treatment of patients with metastatic liver cancer.

Arai, Yasuaki; Kido, Choichiro

1987-12-01

108

Intraarterial infusion chemotherapy for the treatment of metastatic liver cancer  

International Nuclear Information System (INIS)

Some techniques of the most recent interventional radiology are very useful for the treatment of metastatic liver cancer and changing the style of hepatic infusion chemotherapy. This report shows our latest results and methods of hepatic infusion chemotherapy for metastatic liver cancer. 1. For the catheter placement, a new catheterization route via the left subclavian artery into the hepatic artery was developed and performed in 132 cases. Superselective catheterization succeeded in 123 cases (93.2 %). This procedure is less invasive than laparotomy and less troublesome than other percutaneous routes. 2. For useful infusion system, an implantable injection port ''Reservoir'' was developed and it was used in 87 cases. This method makes arterial infusion chemotherapy easy, and imploves their quality of life. 3. To acquire adequate drug delivery, arterial redistribution by steel coils was done, and 109 arteries in 80 cases were occluded. This method is very useful to make multiple hepatic artery single and it is important to avoid gasroduodenal complications. 4. Now, using these techniques, the phase II study of 5FU, ADM, MMC combined hepatic infusion in patients with non-resectable metastatic liver cancer is done. Up to this time, such a phase study on arterial infusion chemotherapy was difficult because of technical problems, but these new techniques make it possible. In conclusion, these new methods change the style and conception of hepatic infusion, and these make much progress on the treatment of patients with metastatic liver cancer. (author)

1987-01-01

109

Interdisciplinary development of an intravenous infusion protocol for Orthoclone OKT3.  

Science.gov (United States)

The development and implementation of an infusion protocol for Orthoclone OKT3 (Ortho Biotech, Inc., Raritan, NJ) is described in this article. OKT3 is a potent immunosuppressant drug used to lower the incidence of graft rejection in transplant patients. Nurses and physicians use the protocol described in this article to administer OKT3 to heart and lung transplant patients at our institution. Pharmacokinetics, along with the nursing care, associated with OKT3 administration are described in the protocol section. The benefits of protocol use are reported in the conclusion. PMID:8788828

Byrd, J G; Raulinaitis, A; Burke, P B; Welsh, D

1996-01-01

110

Radiofrequency ablation during continuous saline infusion can extend ablation margins  

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Full Text Available AIM: To determine whether fluid injection during radiofrequency ablation (RFA can increase the coagulation area. METHODS: Bovine liver (1-2 kg was placed on an aluminum tray with a return electrode affixed to the base, and the liver was punctured by an expandable electrode. During RFA, 5% glucose; 50% glucose; or saline fluid was infused continuously at a rate of 1.0 mL/min through the infusion line connected to the infusion port. The area and volume of the thermocoagulated region of bovine liver were determined after RFA. The Joule heat generated was determined from the temporal change in output during the RFA experiment. RESULTS: No liquid infusion was 17.3 ± 1.6 mL, similar to the volume of a 3-cm diameter sphere (14.1 mL. Mean thermocoagulated volume was significantly larger with continuous infusion of saline (29.3 ± 3.3 mL than with 5% glucose (21.4 ± 2.2 mL, 50% glucose (16.5 ± 0.9 mL or no liquid infusion (17.3 ± 1.6 mL. The ablated volume for RFA with saline was approximately 1.7-times greater than for RFA with no liquid infusion, representing a significant difference between these two conditions. Total Joule heat generated during RFA was highest with saline, and lowest with 50% glucose. CONCLUSION: RFA with continuous saline infusion achieves a large ablation zone, and may help inhibit local recurrence by obtaining sufficient ablation margins. RFA during continuous saline infusion can extend ablation margins, and may be prevent local recurrence.

Toru Ishikawa

2013-01-01

111

Hepatobiliary scintigraphy in patients receiving hepatic artery infusion chemotherapy  

International Nuclear Information System (INIS)

Hepatic artery infusion chemotherapy is used in the treatment of certain selected hepatic tumors, especially metastatic adenocarcinoma of the colon. Chemical cholecystitis has been recognized recently as a complication of hepatic artery infusion chemotherapy. The authors performed hepatobiliary scans on ten patients receiving hepatic artery infusion chemotherapy. All ten patients had abnormal hepatobiliary scintigraphy. They present case reports of three patients with abnormal hepatobiliary scans who have required cholecystectomy for symptoms of chemical cholecystitis to illustrate the clinical, scintigraphic, and pathologic findings in these patients

1985-01-01

112

Hepatobiliary scintigraphy in patients receiving hepatic artery infusion chemotherapy  

Energy Technology Data Exchange (ETDEWEB)

Hepatic artery infusion chemotherapy is used in the treatment of certain selected hepatic tumors, especially metastatic adenocarcinoma of the colon. Chemical cholecystitis has been recognized recently as a complication of hepatic artery infusion chemotherapy. The authors performed hepatobiliary scans on ten patients receiving hepatic artery infusion chemotherapy. All ten patients had abnormal hepatobiliary scintigraphy. They present case reports of three patients with abnormal hepatobiliary scans who have required cholecystectomy for symptoms of chemical cholecystitis to illustrate the clinical, scintigraphic, and pathologic findings in these patients.

Housholder, D.F.; Hynes, H.E.; Dakhil, S.R.; Marymont, J.V.

1985-05-01

113

Cardiovascular stability with rapid intravenous infusion of ondansetron.  

Science.gov (United States)

The acute cardiovascular effects of rapid iv administration of the antiemetic ondansetron, a selective serotonin (5-HT3) receptor antagonist were determined in a randomized, blinded, placebo-controlled study. Measurements of heart rate, blood pressure, oxygen saturation and respiratory rate were made preoperatively over a five-minute period which followed a two-minute infusion of the medication. Intraoperative and postoperative data were not collected. None of the variables recorded changed significantly during the infusion or in the observation period which followed. Within the limitations of this study, we detected no cardiovascular change in the five minutes between the end of the drug infusion and the induction of anaesthesia. PMID:8513525

Heyman, J S; Young, M L; Bagshaw, R J; Levy, W J; Geer, R T; Aukburg, S J; Joslyn, A F; Conahan, T J

1993-05-01

114

Intestinal levodopa infusion: the Belgian experience.  

Science.gov (United States)

Data concerning efficacy, safety, and patient satisfaction of levodopa/carbidopa intestinal gel (LCIG, Duodopa, AbbVie, Wavre, Belgium) infusion in routine clinical practice were needed to maintain reimbursement of the drug in Belgium. Patients with advanced Parkinson's disease in 27 neurology centers across Belgium were included. Of 100 patients who underwent naso-intestinal (NI) evaluation with LCIG, 67 received permanent treatment with LCIG via percutaneous endoscopic gastrostomy and jejunal tube (PEG/J). Efficacy was evaluated at baseline (on levodopa) and during a follow-up (FU) visit (on LCIG) using the Unified Parkinson's Disease Rating Scale (UPDRS) IV. Patient appraisal of the Duodopa system was evaluated using a visual analog scale for therapy compliance, user-friendliness, and global appreciation. Safety was assessed by reporting suspected adverse drug reactions (ADRs) and medical device-related complaints. FU evaluations were conducted in 37 patients. Significant improvement at FU was observed for motor complications (UPDRS IV) as the mean change from baseline to FU was -6.3 (95 % CI -8.1 to -4.5). Patient appraisal showed high scores for hospital delivery, user-friendliness, and patient global appreciation, as well as family appreciation of the system on daily life. Few ADRs and system malfunctions were reported, with no unexpected ADRs. In conclusion, the symptoms and impact of Parkinsonism improved markedly when LCIG PEG/J was initiated. PMID:24379105

Pickut, Barbara Anne; van der Linden, Chris; Dethy, Sophie; Van De Maele, Hilde; de Beyl, Diederik Zegers

2014-06-01

115

Cesarean Sections  

Science.gov (United States)

... come home sooner and recover quicker after a vaginal delivery. However, C-sections can help women at risk ... has a medical condition that could make a vaginal delivery risky for herself or the baby (such as ...

116

Radionuclide localization of intraarterial infusions in head and neck cancer  

International Nuclear Information System (INIS)

The therapeutic advantage of intraarterial infusion chemotherapy depends upon delivery of a high drug concentration to the entire tumor bulk with maximum sparing of critical normal tissues. It is clear that successful application of regional therapy must include methodology to assess quantitatively and qualitatively the infused area. /sup 99m/Tc macroaggregated albumin (Tc-MAA) injected intraarterially is held on first pass in the arteriolar capillary bed, thus providing a map of blood flow distribution. Analog and digital planar images and single photon emission computed tomography (SPECT) after Tc-MAA injections provide static and transaxial tomographic images of head and neck intraarterial infusions. SPECT can be viewed as an endless movie-type display, thus producing a rotating cimematic display. These radionuclide localization techniques provide a three-dimensional delineation of the tissues infused, including subsurface details not appreciated with dye injection alone. These procedures should be considered an integral part of intraarterial therapy of head and neck cancer

1984-01-01

117

De-stressing infusion in outburst-prone steep faces  

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An account is given of de-stressing measures taken in a steep face in the Sonnenschein seam at Consolidation Colliery. The equipment used for infusion, as well as test drilling operations and follow-up test drilling are described. De-stressing infusion has been shown to be a successful process which can be readily integrated into the operational cycle. A displacement of the stress zone close to the coalface usually took place with an infused water volume of 700 l per hole, an initial pressure of more than 200 bar and a pressure difference between beginning and end of some 100 bar. A wet follow-up testing method made possible an immediate confirmation of the effectiveness and range of de-stressing infusion.

Grosskreuz, H.

1984-03-08

118

Intravenous infusion of sterile water for the treatment of hypernatraemia.  

Science.gov (United States)

Little research has been carried out into the infusion of intravenous sterile water for the treatment of hypernatraemia, and it remains a contentious issue. We conducted a review of the literature and extract results following an extensive search of Medline 1946, Embase 1974, ProQuest, evidence-based practice resources, national and international guideline sites and the publications of various professional bodies. The review is presented on the infusion of sterile water (hypotonic fluid) to lower serum sodium level in those circumstances when enteral supplementation of water is not possible, such as in postoperative patients or when other isotonic fluids (such as 5% dextrose in water infusion) are less than ideal-for example, hyperglycaemic patients on an insulin infusion. Absence of guidelines has limited the use of sterile water, even as an off-label drug when it can be administered relatively safely via a central line. PMID:24580394

Ramaswamykanive, H; Greaves, J

2014-03-01

119

Infusion device standardisation and dose error reduction software.  

Science.gov (United States)

In 2004, the National Patient Safety Agency (NPSA) released a safety alert relating to the management and use of infusion devices in England and Wales. The alert called for the standardisation of infusion devices and a consideration of using centralised equipment systems to manage device storage. There has also been growing interest in smart-pump technology, such as dose error reduction software (DERS) as a way to reduce IV medication errors. However, questions remain about the progress that has been made towards infusion device standardisation and the adoption of DERS. In this article, the authors report the results of a survey investigating the extent to which the standardisation of infusion devices has occurred in the last 10 years and centralised equipment libraries are being used in practice, as well as the prevalence of DERS use within the UK. Findings indicate that while reported standardisation levels are high, use of centralised equipment libraries remains low, as does DERS usage. PMID:25062367

Iacovides, Ioanna; Blandford, Ann; Cox, Anna; Franklin, Bryony Dean; Lee, Paul; Vincent, Christopher J

2014-07-01

120

Inhibition of Insulin Secretion by Infused Epinephrine in Phesus Monkeys.  

Science.gov (United States)

The effect of infused l-epinephrine bitartrate on plasma insulin levels has been studied in the fasted, normal, waking rhesus monkey, with chronically implanted venous catheters. It was demonstrated that sharp rises in peripheral plasma glucose levels dur...

A. O. Kris R. E. Miller F. E. Wherry J. W. Mason

1965-01-01

 
 
 
 
121

A Framework for Infusing Multicultural Curriculum into Gifted Education.  

Science.gov (United States)

This article offers a framework for infusing multicultural curriculum into gifted education that integrates two, heretofore, parallel models in education, Benjamin Bloom's taxonomy of educational objectives (1956) and Banks and Banks' (1993) model of multicultural education. (Contains 15 references.) (DB)

Ford, Donna Y.; Harris, J. John, III

2000-01-01

122

INTRAVENOUS FENTANYL INFUSION AS AN ANALAGESIC AGENTS FOR LABOR PAIN  

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Full Text Available Introduction. There are few studies about intravenous fentanyl infusion for reduce labor pain. This study evaluate the usefulness of intravenous fentanyl infusion for labor analgesia. Methods. Seventy seven healthy pregnant women were randomized to recive 1.5-2.5µg/kg/hr intravenous fentanyl infusion (interventional group or placebo (control group. Maternal labor pain intensity, systolic, diastolic and mean arterial blood pressure, pulse and respiratory rate, frequency of nausea and vomiting were monitored. Fetal heart rate (FHR and neonatal APGAR score also monitored. Results. Maternal intensity of labor pain, frequency of nausea and FHR changes were significantly lower in interventional group. There was no significant difference between groups about maternal frequency of vomiting, systolic, diastolic and mean arterial pressure, pulse rate and neonatal 1 and 5 min APGAR score. Discussion. Intravenous fentanyl infusion (1.5-2 µg/kg/hr during active phase of labor can diminish labor pain without any side effects of neonate and mother.

H SOLTANI NEZHAD

2001-06-01

123

How to Keep an Infusion Log: Intravenous Immune Globulin (IVIG)  

Science.gov (United States)

... left at the end is a highly purified immunoglobulin preparation that has only trace (intravenous (IV) infusion. In the usual case, the immunoglobulin replacement lasts approximately one month in the patient ...

124

COMPENSATORY CHANGES IN THE HIPPOCAMPUS FOLLOWING INTRADENTATE INFUSION OF COLCHICINE  

Science.gov (United States)

Direct infusion of colchicine into the dentate gyrus of the hippocampus kills granule cells and elicits compensatory behavioral, neurochemical and neuroanatomical changes. olchicine-treated rats are less sensitive to the behavioral effects of cholinergic muscarinic receptor antag...

125

Secondary prophylaxis with factor IX concentrates: continuous infusion  

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Haemophilia patients may require prolonged treatment during peri-operative period or life-threatening bleedings. Intermittent bolus infusions of factor concentrates have been used successfully for many years. However, pharmacokinetics may vary among products and patients, and the wide fluctuations in factor levels during therapy can make management inaccurate and unsafe. Specific protocols for continuous infusion have been developed, which may decrease factor utilization, facilitate laborator...

Morfini, Massimo

2008-01-01

126

Infusing Software Engineering Technology into Practice at NASA  

Science.gov (United States)

We present an ongoing effort of the NASA Software Engineering Initiative to encourage the use of advanced software engineering technology on NASA projects. Technology infusion is in general a difficult process yet this effort seems to have found a modest approach that is successful for some types of technologies. We outline the process and describe the experience of the technology infusions that occurred over a two year period. We also present some lessons from the experiences.

Pressburger, Thomas; Feather, Martin S.; Hinchey, Michael; Markosia, Lawrence

2006-01-01

127

Evaluation of maternal infusion therapy during pregnancy for fetal development  

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The aim of this project was to study the possible association between maternal infusion treatments during pregnancy and variables of fetal development as well as the occurrence of congenital abnormalities (CA) in a case-control design. The large population-based data set of the Hungarian Case?Control Surveillance of Congenital Abnormalities (HCCSCA) was evaluated based on the medically recorded infusion treatment during pregnancy. Of 22,843 case pregnant women who had newborns or fetuses wi...

Petik, Do?ra; Puho?, Erzse?bet; Czeizel, Andrew E.

2005-01-01

128

Role of saline infusion sonography in abnormal uterine bleeding  

Directory of Open Access Journals (Sweden)

Conclusions: We found Saline Infusion Sonography to be an easy and safe procedure, though being less sensitive, it cannot replace hysteroscopy as a whole. Though hysteroscopy is a gold standard, saline infusion sonography is an easy, safe procedure for diagnosing intracavitary pathologies in low resource setting and despite being less sensitive, it can still reduce the number of hysteroscopies. [Int J Reprod Contracept Obstet Gynecol 2013; 2(4.000: 533-538

Megha Sharma

2013-08-01

129

Isolation and characterization of polysaccharides from Fraxinus angustifolia infusions  

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In folk medicine there is a great variety of plants that are used for as infusions, such as Camellia sinensis and Matricaria recutita. Despite the reported biological activities and health benefits of these infusions, most of the knowledge achieved so far is based on folk tradition passed over several generations, without a sound scientific basis. In Trás-os-Montes region, the dried leaves of the narrow-leafed ash “freixo” (Fraxinus angustifolia) are used for medicinal purposes, part...

Martins, Vitor Manuel Ramalheira; Coimbra, Manuel A.

2012-01-01

130

Isolation and characterization of polysaccharides from Fraxinus angustifolia infusions  

Digital Repository Infrastructure Vision for European Research (DRIVER)

In folk medicine there is a great variety of plants that are used for as infusions, such as Camellia sinensis and Matricaria recutita. Despite the reported biological activities and health benefits of these infusions [1,2], most of the knowledge achieved so far is based on folk tradition passed over several generations, without a sound scientific basis. In Trás-os-Montes region, the dried leaves of the narrow-leafed ash “freixo” (Fraxinus angustifolia) are used for medicin...

Martins, Vitor Manuel Ramalheira; Coimbra, Manuel A.

2012-01-01

131

Effect of phenylephrine infusion on atrial electrophysiological properties.  

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OBJECTIVE: To determine the effect of changes in autonomic tone induced by phenylephrine infusion on atrial refractoriness and conduction. DESIGN: Left and right atrial electrophysiological properties were measured before and after a constant phenylephrine infusion designed to increase sinus cycle length by 25%. SUBJECTS: 20 patients, aged 53 (SD 6) years, undergoing electrophysiological study for investigation of idiopathic paroxysmal atrial fibrillation (seven patients) or for routine follo...

Leitch, J. W.; Basta, M.; Fletcher, P. J.

1997-01-01

132

Identifying value constellations for service infusion in SMEs  

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Manufacturing firms have always delivered services, by supplying spare parts, installing equipment, training employees, or performing maintenance. In competitive markets though, firms seek new ways to differentiate their business, including an increased focus on service, often referred to as service infusion. Of the studies that seek to understand this phenomenon, most focus on large multinational firms; little is known about service infusion in small and medium-sized enterprises (SMEs). This...

2013-01-01

133

Haemolytic uraemic syndrome: therapeutic effect of plasma infusion.  

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The therapeutic effect of plasma infusion was evaluated in 10 children and seven adults with haemolytic uraemic syndrome. All but one patient responded to this treatment with rapid disappearance of haematological abnormalities. The patient who apparently failed to respond to plasma infusion obtained complete remission of the disease after plasmapheresis. Although 15 of the 17 patients were anuric or oliguric on admission, renal function recovered completely in eight children and two adults. S...

Misiani, R.; Appiani, A. C.; Edefonti, A.; Gotti, E.; Bettinelli, A.; Giani, M.; Rossi, E.; Remuzzi, G.; Mecca, G.

1982-01-01

134

Evaluation of maternal infusion therapy during pregnancy for fetal development  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The aim of this project was to study the possible association between maternal infusion treatments during pregnancy and variables of fetal development as well as the occurrence of congenital abnormalities (CA) in a case-control design. The large population-based data set of the Hungarian Case?Control Surveillance of Congenital Abnormalities (HCCSCA) was evaluated based on the medically recorded infusion treatment during pregnancy. Of 22,843 case pregnant women who had newborns or fet...

Petik Dóra; Puhó Erzsébet; Czeizel Andrew E

2005-01-01

135

Vascular responses to local atrial natriuretic peptide infusion in man.  

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1. The effect on skin and muscle blood flow of arterial infusion of atrial natriuretic peptide (ANP) directly into the forearm circulation, and on venous tone of direct infusion into a dorsal hand vein, was studied in normal subjects. 2. ANP produced a dose-dependent increase in both skin and muscle blood flow, but at equivalent doses, produced no dilatation of noradrenaline-preconstricted dorsal hand veins. These findings indicate that ANP acting locally, is an arterioselective dilator in th...

1988-01-01

136

Haemorrheological effects of prostaglandin E1 infusion in Raynaud's syndrome.  

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Eighteen patients with severe Raynaud's syndrome had impaired deformability of erythrocytes, as measured by filtration through 5 micron diameter pores, compared with 19 healthy controls. The patients were given prostaglandin E1 (PGE1) or placebo by intravenous infusion for 72 h to assess the haemorrheological action of PGE1. Contrary to a previous report, PGE1 did not improve erythrocyte filterability. Infusion of PGE1 did, however, evoke an acute phase response with hyperproteinaemia and a l...

Lucas, G. S.; Simms, M. H.; Caldwell, N. M.; Alexander, S. J.; Stuart, J.

1984-01-01

137

Prepreg and infusion processes for modern wind turbine blades  

Energy Technology Data Exchange (ETDEWEB)

The different elements of wind turbine blades have been analyzed for their main function, performance requirements and drivers. Key drivers can be simplified to either performance or cost. The use of prepreg and infusion to make these blade elements has then been compared and shows, from a comparison of test laminates, that prepreg typically delivers higher mechanical performance on both glass and carbon. One of the main process differences, cure temperature, has been overcome with the introduction of M79 which cures at 70 deg. - 80 deg. C. M79 combines this low cure temperature with a much lower reaction enthalpy allowing shorter cure cycles. This means that prepregs can now be cured in the same molds, at the same temperatures and with the same foam as used in a conventional infusion process. Although prepreg and infusion are usually used separately for making blade elements, they may also be used in combination: co-infused and co-cured using prepregs for the hard to infuse unidirectional load-carrying elements and infusion for the other elements. This can thus simplify the production process. The conclusion is that unidirectional prepregs are ideally suited for the performance driven parts of the blade such as in load carrying elements. (Author)

Shennan, C. [Hexcel, Cambridge (United Kingdom)

2013-09-01

138

Tracer studies with aortic infusion result in improper tracer distribution  

International Nuclear Information System (INIS)

It has been suggested that lactate turnover can be accurately assessed by infusing radioactive lactate tracer into the aorta and sampling blood in the vena cava. However, there may be streaming of newly infused tracer in the aorta, resulting in a nonuniform arterial specific activity (SA). Furthermore vena caval blood may not be representative of mixed venous blood. The authors examined this problem in 7 anesthetized dogs with sampling catheters in the pulmonary (PA), carotid (CA), and femoral (FA) arteries, and the superior (SVC) and inferior (IVC) vena cavi. [1-"1"4C]lactate was continuously infused into the left ventricle through a catheter introduced through the femoral artery. The same SA (dpm/?mol) was found in the CA and FA, indicating adequate mixing of newly infused tracer with trace. Three dogs showed differences between SVC, IVC and PA, suggesting a mixed venous sample can not be obtained from the VC. When the catheter was moved into the aorta, wide differences in SA appeared between the CA and FA, clearly reflecting streaming of tracer. These differences also appeared in the SVC and IVC. In conclusion, adequate mixing does not occur between tracer and trace in arterial blood with aortic infusion. Further, VC sampling will not give a consistent mixed venous SA. Therefore, for practical reasons, aortic tracer infusion with vena caval sampling will lead to erroneous turnover values

1986-03-05

139

Lipolytic response to glucose infusion in human subjects  

International Nuclear Information System (INIS)

The authors have determined the effect of various rates of glucose infusion on the rates of release of glycerol (R/sub a/ glycerol), free fatty acids (R/sub a/ FFA), and on energy metabolism in normal human volunteers. Plasma kinetics were determined with use of the stable isotopic tracers D-5-glycerol and [1-"1"3C]palmitate, and energy metabolism was determined by indirect calorimetry. The effect of glucose infusion on R/sub a/ glycerol and R/sub a/ FFA was dose-dependent. At 4 mg x kg"-"1 x min"-"1, both R/sub a/ glycerol and R/sub a/ FFA were suppressed; at 8 mg x kg"-"1 x min"-"1, R/sub a/ FFA was even more depressed, but R/sub a/ glycerol was similar to the value during the 4 mg x kg"-"1 x min"-"1 infusion. At all infusion rates tested, the amount of potential energy available from the sum of the glucose infusion and endogenously mobilized fat was always greater than when no glucose was infused. Glucose decreased fat mobilization by both inhibiting lipolysis and stimulating reesterification, thus causing a significant increase in triglyceride-fatty acid substrate cycling within the adipose tissue. Plasma insulin was determined by radioimmunoassay

1987-01-01

140

Electro-osmotic infusion for joule heating soil remediation techniques  

Energy Technology Data Exchange (ETDEWEB)

Electro-osmotic infusion of ground water or chemically tailored electrolyte is used to enhance, maintain, or recondition electrical conductivity for the joule heating remediation technique. Induced flows can be used to infuse electrolyte with enhanced ionic conductivity into the vicinity of the electrodes, maintain the local saturation of near-electrode regions and resaturate a partially dried out zone with groundwater. Electro-osmotic infusion can also tailor the conductivity throughout the target layer by infusing chemically modified and/or heated electrolyte to improve conductivity contrast of the interior. Periodic polarity reversals will prevent large pH changes at the electrodes. Electro-osmotic infusion can be used to condition the electrical conductivity of the soil, particularly low permeability soil, before and during the heating operation. Electro-osmotic infusion is carried out by locating one or more electrodes adjacent the heating electrodes and applying a dc potential between two or more electrodes. Depending on the polarities of the electrodes, the induced flow will be toward the heating electrodes or away from the heating electrodes. In addition, electrodes carrying a dc potential may be located throughout the target area to tailor the conductivity of the target area.

Carrigan, C.R.; Nitao, J.J.

1999-11-02

 
 
 
 
141

Electro-osmotic infusion for joule heating soil remediation techniques  

Energy Technology Data Exchange (ETDEWEB)

Electro-osmotic infusion of ground water or chemically tailored electrolyte is used to enhance, maintain, or recondition electrical conductivity for the joule heating remediation technique. Induced flows can be used to infuse electrolyte with enhanced ionic conductivity into the vicinity of the electrodes, maintain the local saturation of near-electrode regions and resaturate a partially dried out zone with groundwater. Electro-osmotic infusion can also tailor the conductivity throughout the target layer by infusing chemically modified and/or heated electrolyte to improve conductivity contrast of the interior. Periodic polarity reversals will prevent large pH changes at the electrodes. Electro-osmotic infusion can be used to condition the electrical conductivity of the soil, particularly low permeability soil, before and during the heating operation. Electro-osmotic infusion is carried out by locating one or more electrodes adjacent the heating electrodes and applying a dc potential between two or more electrodes. Depending on the polarities of the electrodes, the induced flow will be toward the heating electrodes or away from the heating electrodes. In addition, electrodes carrying a dc potential may be located throughout the target area to tailor the conductivity of the target area.

Carrigan, Charles R. (Tracy, CA); Nitao, John J. (Castro Valley, CA)

1999-01-01

142

Tracer studies with aortic infusion result in improper tracer distribution  

Energy Technology Data Exchange (ETDEWEB)

It has been suggested that lactate turnover can be accurately assessed by infusing radioactive lactate tracer into the aorta and sampling blood in the vena cava. However, there may be streaming of newly infused tracer in the aorta, resulting in a nonuniform arterial specific activity (SA). Furthermore vena caval blood may not be representative of mixed venous blood. The authors examined this problem in 7 anesthetized dogs with sampling catheters in the pulmonary (PA), carotid (CA), and femoral (FA) arteries, and the superior (SVC) and inferior (IVC) vena cavi. (1-/sup 14/C)lactate was continuously infused into the left ventricle through a catheter introduced through the femoral artery. The same SA (dpm/..mu..mol) was found in the CA and FA, indicating adequate mixing of newly infused tracer with trace. Three dogs showed differences between SVC, IVC and PA, suggesting a mixed venous sample can not be obtained from the VC. When the catheter was moved into the aorta, wide differences in SA appeared between the CA and FA, clearly reflecting streaming of tracer. These differences also appeared in the SVC and IVC. In conclusion, adequate mixing does not occur between tracer and trace in arterial blood with aortic infusion. Further, VC sampling will not give a consistent mixed venous SA. Therefore, for practical reasons, aortic tracer infusion with vena caval sampling will lead to erroneous turnover values.

Wisneski, J.A.; Brooks, G.A.; Neese, R.A.; Stanley, W.C.; Morris, D.L.; Gertz, E.W.

1986-03-05

143

Volatile fraction of lavender and bitter fennel infusion extracts.  

Science.gov (United States)

The relative proportions of chemical classes (hydrocarbons, oxides, alcohols/ethers, aldehydes/ketones, acids/esters/lactones) in the essential oil of lavender (Lavendula angustifolia Mill., family Lamiaceae) and bitter fennel (Foeniculum vulgare Mill. subsp. vulgare var. vulgare (Mill.) Thellung, family Apiaceae) and in the volatile fraction of infusion extracts were examined and showed remarkable differences. The volatile compounds of infusions were isolated by hydrodistillation and solid phase extraction (SPE). Their qualitative and semiquantitative compositions were compared with the essential oil isolated by hydrodistillation directly from the plant material and analyzed by GC-MS. Furthermore, quantification of the major constituents of lavender oil and of the volatile fraction obtained by hydrodistillation of the infusion was performed. Comparison of the total essential oil yield quantified by hydrodistillation of the lavender infusion (0.7% v/w, corresponding to plant material) with the essential oil yield of the blossoms (5.1% v/w) revealed that only 13.9% of the initial oil could be extracted by infusion. The main constituents of the volatile fraction of the lavender infusion were (hydrodistillation/SPE): linalool (39.3%/28.2%), 1,8 cineole (24.8%/18.9%), cis-linalool oxide (furanoid) (5.8%/8.0%), trans-linalool oxide (furanoid) (4.1%/7.1%), camphor (5.3%/4.0%) and alpha-terpineol (4.0%/3.0%). The major constituents of lavender essential oil were linalool (28.8%), 1,8-cineole (18.05%), linalyl acetate (13.9%) and alpha-terpineol (4.0%). Most intriguing, in the volatile fraction of lavender infusion a significant proportional decrease of linalyl acetate and an increase of linalool oxides was recognized. The essential oil yield of fennel fruits was 12.5% v/w, whereas 1.8% v/w volatile fraction (corresponding to plant material) was obtained by hydrodistillation of the fennel infusion, which is equivalent to 14.5% of the initial fennel essential oil. The main constituents of the volatile fraction of the fennel infusion were (hydrodistillation/SPE): trans-anethole (56.4%/54.8%), fenchone (36.2%/39.5%) and estragole (2.5%/2.2%), which were also the major compounds of the genuine bitter fennel essential oil. In infusions, the proportion of ethers vs. ketones was shifted significantly towards a higher proportion of the latter compared with the essential oil obtained from the fruits. PMID:20923003

Tschiggerl, Christine; Bucar, Franz

2010-09-01

144

Physical and chemical stability of cisplatin infusions in PVC containers  

Directory of Open Access Journals (Sweden)

Full Text Available Study objectives: To determine the extended chemical and physical stability of cisplatin infusions in PVC containers at normal in-use concentrations in saline, with and without added electrolyte combinations relevant to clinical practice. Methods: Cisplatin infusions 0.1–0.4 mg/mL were prepared in normal saline, with and without magnesium sulphate and potassium chloride supplements in 500 mL PVC bags, and stored at 25°C protected from light. Chemical stability was assessed by a stability-indicating LC method. Evidence for precipitation was detected by a light-blocking particle count method for sub-visible particles, supported by visual examination. pH and weight changes were also monitored for at least 28 days. Results: Both 0.1 mg/mL and 0.4 mg/mL infusions, with or without the added electrolyte supplements, were chemically stable over 28 days at 25°C. The pH of infusions varied by no more than 0.2 units over this time, there was no visible precipitation, and no significant changes in sub-visual particulate levels or infusion weight. The study was restricted to 28 days because small, visual precipitation was evident in some infusions after 35 days. Conclusion: Cisplatin infusions at concentrations ranging from 0.1–0.4 mg/mL, in 500 mL PVC bags containing either 0.9% sodium chloride or 0.9% sodium chloride + 20 mmoL KCl + 8 mmoL MgSO4 were physically and chemically stable for up to 28 days at 25°C, when protected from light. Extending shelf lives beyond this period is unsafe due to the potential development of precipitates.

Graham Sewell

2010-01-01

145

Demonstration of the dorsal pancreatic artery by CTA to facilitate superselective arterial infusion of stem cells into the pancreas  

International Nuclear Information System (INIS)

Purpose: To investigate the diagnostic performance of 64-section CTA in the detection of dorsal pancreatic artery before interventional therapy for patients with diabetes. Materials and methods: The study was approved by the institutional ethics committee; written informed consent was obtained. Forty-two consecutive patients with diabetes received an experimental treatment of autologous bone marrow-derived stem cell transplantation by means of infusion into the dorsal pancreatic artery. All cases underwent abdominal CTA before angiography of pancreatic arteries in order to locate the origin and course of dorsal pancreatic artery. Angiography of coeliac artery, splenic artery, common hepatic artery and superior mesenteric artery were performed both in CTA and DSA. Superselective catheterization of dorsal pancreatic artery was carried out for the infusion of stem cell. Sensitivity, specificity and accuracy for the detection of dorsal pancreatic artery with CTA were calculated using DSA images as the reference standard. Results: Thirty-five and thirty-six dorsal pancreatic arteries were detected by CTA and DSA respectively. Dorsal pancreatic artery was not visualized in either CTA or DSA in 5 patients. The sensitivity, specificity and accuracy for CTA were 94.4%, 83.3% and 92.9%. Conclusion: 64-section CTA is accurate for the detection of dorsal pancreatic artery. It may be useful for the facilitation of superselective arterial infusion of stem cells to pancreas.

2012-03-01

146

Longwall dust control potentially enhanced by surface borehole water infusion  

Energy Technology Data Exchange (ETDEWEB)

Injecting pressurized water into a coalbed prior to mining reduces mining-generated respirable dust. Because of economic and geological barriers, water infusion for longwall dust control in the United States is now limited to the Pocahontas No. 3 Coalbed in Virginia. Water is pumped into the coalbed through underground boreholes that are drilled horizontally from the headgate toward the tailgate side of retreat longwall panels. This paper theorizes that the barriers to wide-spread utilization of water infusion for longwall dust control could be overcome by long-duration, low-pressure water infusion through vertical gob-gas boreholes. Currently, 43% of the 72 longwall mines in the United States employ vertical gob-gas boreholes. Computer coalbed-reservoir simulation suggests that one vertical surface borehole could infuse the same longwall panel areas as four horizontal boreholes in the current water-infusion system for longwall dust control in the Pocahontas No.3 Coalbed. 8 refs., 5 figs., 2 tabs.

Campoli, A.A.; McCall, F.E.; Finfinger, G.L.; Zuber, M.D. [GAI Consultants, Inc., Charleston, WV (United States)

1996-07-01

147

De-stressing infusion in outburst-prone steep faces  

Energy Technology Data Exchange (ETDEWEB)

Rockburst prevention had to be practised at Consolidation Colliery in the Sonnenschein seam. Problems arise especially in faces. Extensive testing and destressing measures in a steep face in which 80% of test drillings gave critical values are described in this article. Apart from the Mines Inspectorate requirements about de-stressing infusion, the technical equipment used and improved in this face is demonstrated. A detailed account is given of the execution of test measures, de-stressing infusion and results verification with dry and wet follow-up test drilling. The improvements made in equipment and method turned de-stressing infusion into a successful process which can be readily integrated into the operational cycle. Usually, a displacement of the stress zone close to the coalface took place with an infused water volume of 700 l per hole, an initial pressure of over 200 bar and a pressure difference between start and end of about 100 bar. The wet follow-up testing method developed here made possible an immediate confirmation of the effectiveness and reach of de-stressing infusion. This rockburst-prone face could not have worked with the use of de-stressing drilling rigs for safety, organisational and economic reasons.

Grosskreuz, H.

1984-03-08

148

Effects of adenosine infusion into renal interstitium on renal hemodynamics  

International Nuclear Information System (INIS)

This study was designed to investigate the hemodynamic effects of exogenous adenosine in the interstitium of the rat kidney. Adenosine or its analogues were infused into the renal interstitium by means of chronically implanted capsules. In fusion of adenosine decreased glomerular filtration rate (GFR) from 0.81 +/- 0.06 to 0.37 +/- 0.06 ml/min while having no effect on renal blood flow (RBF). The metabolically stable analogue, 2-chloradenosine (2-ClAdo), decreased GFR from 0.73 +/- 0.07 to 021 +/- 0.06 ml/min. Interstitial infusion of theophylline, an adenosine receptor antagonist, completely abolished the effects of adenosine and 2-ClAdo on GFR. The distribution of adenosine, when infused into the renal interstitium, was determined using radiolabeled 5'-(N-ethyl)-carboxamidoadenosine (NECA), a metabolically stable adenosine agonist. After continuous infusion, [3H]NECA was distributed throughout the kidney. The effects of NECA to reduce GFR were similar to those of adenosine and 2-ClAdo. They conclude that increased levels of adenosine in the renal interstitium markedly decrease GFR without affecting RBF in steady-state conditions. The marked effects of adenosine agonists during their infusion into the renal interstitium and the complete blockade of these effects by theophylline suggest an extracellular action of adenosine

1987-01-01

149

Auditory brainstem responses during systemic infusion of lidocaine.  

Science.gov (United States)

Auditory brainstem-evoked responses (ABR) to clicks were recorded in unanesthetized restrained cats before, during, and after systemic intravenous infusion of lidocaine hydrochloride. The drug was infused continuously at varying rates. Lidocaine's major effect on ABR was to lengthen latent periods to all wave-form peaks in proportion with the infusion rate. The effect on latent periods was cumulative throughout the auditory brainstem, ie, all interpeak time intervals increased. Increases in ABR latencies were not due to reductions in effective stimulus intensity because lidocaine did not reduce ABR component amplitudes or increase thresholds. The effects of the drug were reversible. The data are consistent with the notion that lidocaine, directly or indirectly, works throughout the auditory brainstem to increase axonal and synaptic conduction times. PMID:7059316

Javel, E; Mouney, D F; McGee, J; Walsh, E J

1982-02-01

150

Continuous infusion with implantable pumps: expanding the radiologist's role.  

Science.gov (United States)

Drug infusion systems attract increasing attention as biomedical technology offers miniaturized devices for targeted delivery of therapeutic substances on an outpatient basis. We have used a totally implantable, subcutaneous pump, externally programmable by radiofrequency link, learning the technique of implantation and management and using various imaging modalities for the diagnosis and control of complications. The procedure for implanting systems for continuous intrathecal analgesia and systemic intravenous chemotherapy is described. Our experience of the latter is made up of 296 implants in 290 patients. The selected infusion pump proved reliable and acceptable to patients and the quality of life, given the reduced drug toxicity, more than good. The complications were few both in frequency and in severity. The setting-up of a long-term infusion system, when major surgery is not needed, can fall within the interventional radiologist's field, partly because of a good cost-benefit ratio. PMID:1906807

Damascelli, B; Bonalumi, M G; Marchianò, A; Spreafico, C; Garbagnati, F; Amadeo, A; Salvetti, M; Frigerio, L F; Piragine, G; Cesa Bianchi, A

1991-01-01

151

Apomorphine and levodopa infusion therapies for advanced Parkinson's disease.  

Science.gov (United States)

Continuous infusion of levodopa or apomorphine provide constant dopaminergic stimulations are good alternatives to deep brain stimulation to control motor fluctuations in patients with advanced Parkinson's disease (PD). Apomorphine provides motor benefit similar to dopamine, but its long-term use is limited by compliance, mostly injection site skin reactions. Administration of levodopa/carbidopa by continuous duodenal infusion allows replacement of all oral medications and permits achievement of a satisfactory therapeutic response paralleled by a reduction in motor complication severity. However, this procedure is more invasive than apomorphine as it requires a percutaneous endoscopic gastrostomy Clinical experience with infusions shows that continuous dopaminergic stimulation of dopaminergic medications reduces dyskinesia and widens the therapeutic window in advanced PD. PMID:24868344

Antonini, Angelo

2009-05-01

152

Assessing patient preference for two types of elastomeric infusion device.  

Science.gov (United States)

Home administration of antibiotic therapy to cystic fibrosis patients is one of many applications for the use of elastomeric infusion devices. Patient acceptability can significantly affect adherence to complex drug regimens with concordance being a concern in this patient population. While patient acceptance is often cited as a factor in pump selection, patient preference has not been assessed within a particular class of infusion device. The objective of this study was to assess patient preference for one type of elastomeric infusion device (Baxter Intermate--hard-shelled design) or another (Fresenius Kabi Eclipse--soft-shelled design). Twenty-four patients entered the study. 20/24 (83%) patients expressed a preference for the Eclipse, while 4/24 (17%) stated no preference for either device. The Eclipse device was found to be much more favourable in terms of comfort and discreetness. Patient preference should therefore be given significant consideration in order to maximize concordance with drug regimens. PMID:18026019

Dodd, Susan

153

Composition of antioxidants and amino acids in Stevia leaf infusions.  

Science.gov (United States)

Stevia, a non-caloric natural sweetener with beneficial properties and considerable antioxidants and amino acids, is increasingly consumed as an infusion. This work evaluates the influence of the conditions (temperature: 50, 70 or 90 °C and time: 1, 5, 20 or 40 min) applied to obtain Stevia infusions, on antioxidants (total phenols, flavonoids and antioxidant activity) and amino acids. The total concentration of the eleven amino acids found was 11.70 mg/g in dried leaves and from 6.84 to 9.11 mg/g per gram of Stevia in infusions. However, infusions showed higher levels of certain amino acids (alanine, asparagine, leucine and proline), and greater values of the three antioxidant parameters in comparison with dry leaves. Temperature had more influence (minimum values at 50 °C and maximum at 90 °C) than time in the case of antioxidants. At 90 °C there were no important increases in the extraction of antioxidant compounds after 5 min; each gram of Stevia had 117 mg trolox (total antioxidant activity), 90 mg gallic acid (total phenols) and 56 mg catechin equivalents (flavonoids). Varying the temperature and time conditions no notable differences were observed in the concentrations of the majority of amino acids. However, the infusion treatment at 90 °C for 5 min was the best, as it gave the highest yield of 8 of the 11 amino acids. Therefore, with respect to the compounds analyzed in this study, the best way to obtain Stevia leaf infusions is the same as the domestic process, almost boiling water for a short time. PMID:24293005

Periche, Angela; Koutsidis, Georgios; Escriche, Isabel

2014-03-01

154

Radionuclide venography using continuous Kr-81 m infusion: preliminary note  

International Nuclear Information System (INIS)

Continuous infusion of Kr-81m presents important advantages compared to the commonly used radionuclides for venography. High count rates can be accumulated, and a high resolution collimator can be employed to ensure good quality images. The study can be repeated immediately and multiple views can be performed until a satisfactory result is obtained. The production of radionuclide from a Rb-81--Kr-81m generator suitable for intravenous infusion is almost the same as that which is suitable for ventilation. The same generator can first be used for venography and then for ventilation imaging to complete the work-up patients suspected of having thromboembolic disease

1981-01-01

155

Melissa officinalis and Passiflora caerulea infusion as physiological stress decreaser  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The objective of this study was to determine the effect of a Melissa officinalis and Passiflora caerulea infusion on the severity of physiological chronic stress induced by movement restriction in CF-1 mice. 40 CF-1 male mice, six weeks of age, were divided into 4 groups (n = 10 for each group): (1) Group RS/MP received two treatments, induced stress through movement restriction and a infusion of Melissa officinalis and Passiflora caerulea in a dose of 200 mg/kg, (2) RS group with induced str...

Feliu?-hemmelmann, Karina; Monsalve, Francisco; Rivera, Ce?sar

2013-01-01

156

Pharmacokinetics of Ertapenem following Intravenous and Subcutaneous Infusions in Patients?  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Steady-state pharmacokinetics of ertapenem were compared in patients after 1-g intravenous and subcutaneous (s.c.) infusions. Bioavailability was 99% ± 18% after s.c. administration, but peaks were reduced by about (43 ± 29 versus 115 ± 28 ?g/ml) and times to peak were delayed. Simulations based on unbound concentrations show that time over the MIC should always be longer than 30% to 40% of the dosing interval, suggesting that s.c. infusion could be an alternative in patients with reduced...

Frasca, Denis; Marchand, Sandrine; Petitpas, Franck; Dahyot-fizelier, Claire; Couet, William; Mimoz, Olivier

2010-01-01

157

Effect of Insulin Infusion on Liver Protein Synthesis during Hemodialysis  

DEFF Research Database (Denmark)

Background Hemodialysis (HD) is a catabolic procedure that may contribute to the high frequency of protein-energy wasting among patients receiving maintenance HD. The present study investigated the additional effect of glucose and glucose-insulin infusion on liver protein synthesis during HD compared with a meal alone. Methods In a randomized cross-over study with three arms, 11 non-diabetic HD patients were assigned to receive a conventional HD session with either: � no treatment (NT) � IV infusion of glucose (G) � IV infusion of glucose-insulin (GI) During infusions blood glucose levels were maintained at 8.0-10.0 mmol/L by additional glucose infusion. Glucose and glucose-insulin infusions were commenced 2 h prior to HD and continued throughout the HD session. Fasting blood samples were collected at baseline before infusion and followed by the only meal allowed during the study. Results Blood glucose and insulin: The change in blood glucose differed significantly from baseline (-120 min) to end of HD (240 min) between the NT group and the G group (p=0.002); there was no significant difference in the change between the NT group and the GI group (p=0.06), or between the G group and the GI group (p=0.15). Fibrinogen and albumin: There was an overall increase in serum albumin (38.8±2.1 to 40.4±2.5 g/L, p<0.0001) and in serum fibrinogen (11.7±1.7 to 12.8±1.8 µmol/L, p<0.0001) from HD start (0 min) to 2 h post HD (360 min), but no significant difference in the change in either albumin (p=0.12) or fibrinogen (p=0.12) between the groups. IGFBP-1: During the first 4 h after baseline (-120 min) we observed an overall decrease in serum IGF-binding protein 1 (IGFBP-1) (from 267±147 to 140±84 µg/L, p<0.0001), but no difference in the change between groups (p=0.41). However, from 4 h after baseline to the end of the study there was a significant difference in the change in serum IGFBP-1 between the groups (p=0.003) with a significant increase in serum IGFBP-1 in the NT group (p<0.0001), but not in the G group or GI group (p=0.50 and p=0.07, respectively). Conclusions Compared with a meal neither glucose nor glucose-insulin infusion appear to have any extra effects on liver protein synthesis during HD.

Reinhard, Mark; Frystyk, Jan

158

An experimental study on the influence of infusion speed on the early mechanism of embolic effect of arterially infused absolute Ethanol in the rat  

Energy Technology Data Exchange (ETDEWEB)

In order to clarify the early mechanism of action of the tissue necrosis induced by intraarterially infused absolute ethanol, abdominal aortography and histopathologic examination after absolute ethanol infusion into aorta at fast (0.4ml/sec) and slow speed (0.04ml/sec) were performed on 22 rats (2 controls, 7 in fast infusion group, 7 in slow infusion group, 3 in fast and 3 in slow infusion groups during aorta compression, respectively). Histopathologic features under the light and scanning electron microscope were correlated with the angiographic findings within 30 minutes after ethanol infusion. The results are as follows : 1. In fast infusion group, histopathologic examination of the kidney showed severe glomerular and tubular damage. Extensive damage on endothelial and medial layer was noted in arteries, and fresh thrombi originated from the damaged arterial wall were seen. 2. Angiographic findings in the fast infusion group were luminal irregularity and early obstruction of large arteries. And circulation time was prolonged. 3. In slow infusion group, histopathologic examination of the kidney showed focal area of severe glomerular and tubular damage on relatively normal background. Endothelial and muscular damage was noted in arteries, but the degree of the damage was less severe than that of the fast infusion group. 4. Angiographic findings in the slow infusion group were focal perfusion defect of the kidney, delayed circulation time, and mild luminal irregularity, but obstruction of the major arteries was not seen.

Han, Joon Koo; Kim, Woo Ho; Lee, Byung Hee; Park, Kil Sun; Park, Jae Hyung; Kim, Chu Wan; Han, Man Chung [College of Medicine, Seoul National Univ., Seoul (Korea, Republic of)

1990-10-15

159

The value of MR enteroclysis with air infusion in the diagnosis of small bowel disease  

International Nuclear Information System (INIS)

Objective: To investigate the value of MR enteroclysis with air infusion in the diagnosis of small bowel disease. Methods: Sixteen patients with suspected small bowel disease, but without acute inflammatory disease or bowel obstruction, received MR enteroclysis with air infusion. There were 12 males and 4 females, and their age ranged from 17 to 75 years. 10 patients had abdominal pain, 4 with melena or blood stool, and 2 with diarrhea. The longest course was 7 years, and the shortest 1 week. Before MR imaging, a nasoenteric catheter was inserted into the distal part of duodenum, and about 1000 ml of air was infused through the tube to distend the small bowel. 20 mg of IV anisodamine was given to reduce small-bowel peristalsis. All patients were imaged with fat-saturated Gd-DTPA enhanced coronal and axial T1-weighted spin-echo (SE) sequence and fast spoiled gradient echo (FSPGR) sequence. Comparison between the diagnosis of MRI and the results of surgery, pathology or clinic was performed to assess the sensitivity and specificity of MRI. Results: 5 cases were normal, 6 with Crohn disease, 2 with gastric intestinal stromal tumor (GIST), and 1 each of lymphoma, tuberculosis and irritable bowel syndrome. The lumen of normal small bowel in MR enteroclysis was no signal, the wall was outlined as middle signal by intraluminal air and surrounding air-distended bowel and was between 1-3 mm thick, and the diameter of the lumen was between 17-28 mm. Crohn disease showed segmental mural thickening, increased enhancement, luminal stricture, and even extraluminal inflammatory mass or fistula. Intestinal tuberculosis invaded the distal section of ileum, cecum, and the proximal ascending colon, the wall thickened and enhanced apparently, and cecum and proximal ascending colon shortened. GIST showed a mass that was iso-signal on T1WI, high signal on T2WI, and enhanced significantly after IV Gd-DTPA. 1 recurrent lymphoma of ileum showed mural thickening and increased enhancement but no stenosis. 1 irritable bowel syndrome is disfunction, so its shape and signal is normal. Except 1 Crohn disease, which showed a large mass, was misdiagnosed as lymphoma and no abnormality was found in 1 irritable bowel syndrome, the other diagnosis of MRI was correct. The sensitivity in diagnosing small intestinal disease was 100%, and the specificity was 83%. Conclusion: MR enteroclysis with air infusion is a sensitive method in diagnosing the small bowel disease, especially in Crohn disease and tumor. It can clearly display the mural thickening and the extraluminal inflammatory mass

2004-05-01

160

Evaluation of oviposition substrates and organic infusions on collection of Culex in Florida.  

Science.gov (United States)

Gravid mosquito traps are commonly used for both arbovirus surveillance and population surveillance of mosquitoes of the genus Culex. Oviposition substrates, used as baits in these traps, were tested against Culex under laboratory and field conditions. In the laboratory all substrates tested as 1% and 10% dilutions in 2-choice bioassays against female Cx. quinquefasciatus were significantly more effective than well water controls in eliciting oviposition. Strongest responses were to dilutions of dairy effluent, followed by larval water and infusions of alfalfa hay, alfalfa pellets, Bermuda hay, oak leaves, and Typha leaves, with lowest responses to cow manure infusion. In the field, few significant differences in collections were obtained between traps baited with different infusions. Significantly more Cx. quinquefasciatus and Cx. nigripalpus were collected in traps baited with cow manure infusion (highest) compared to alfalfa hay infusion (lowest). Responses of Cx. quinquefasciatus to dairy effluent and infusions of Bermuda hay, oak leaves, and Typha leaves were not significantly different from either cow manure infusion or alfalfa hay infusion. Responses of Cx. nigripalpus were highest to cow manure infusion and equally low to infusions of alfalfa hay and Typha leaves; moderate responses were observed to dairy effluent and infusions of Bermuda hay and oak leaves. Gravid females comprised 66.7-81.9% of the collections for each infusion type, with no significant difference among infusions in the proportion of gravid females collected. PMID:16252516

Allan, Sandra A; Bernier, Ulrich R; Kline, Daniel L

2005-09-01

 
 
 
 
161

Diversity Curriculum Infusion within a Film and Video Directing Course  

Science.gov (United States)

This paper reports on the "diversity curriculum infusion" course design process as applied within a Film/Video Directing class at the University of Missouri in Kansas City during the Spring 2006 semester. By custom, film directing has been grounded in aesthetic principles originating in Western European craft and art traditions. While students…

Gutenko, Gregory

2006-01-01

162

[Diuretic activity of the infusion of flowers from Lavandula officinalis].  

Science.gov (United States)

The diuretic activity of an infusion of Lavandula officinalis was studied in the Wistar rat. Thus, the kinetics of hydroelectrolytic elimination in response to the oral administration of an infusion of pharmaceutical lavender flowers were measured in the rats. Experiments were completed under similar conditions using a synthetic pharmacological diuretic, Diamox. The aqueous extract of this aromatic plant accelerated the elimination of the water overload. At the peak of the diuretic response, urinary osmolarity was significantly less than that of controls (111+/-14 vs. 195+/-11 mosmol x kg(-1)). Sodium excretion was moderate following administration of the infusion when compared to the synthetic diuretic. The stability of the aldosterone concentrations in the plasma and the absence of correlation with plasma sodium concentrations, coupled with the observed clearance of the free water (0.055+/-0.007 vs. 0.045+/-0.012 mL x min(-1)) show that the increase in diuresis and the moderate increase in sodium excretion are of tubular origin. The result of the phytochemical analysis of hexane extracts in the infusion and in urine indicated that four or five chemical factors may be involved in the diuretic effect of lavender. PMID:12014366

Elhajili, M; Baddouri, K; Elkabbaj, S; Meiouat, F; Settaf, A

2001-01-01

163

Technique and diagnostic utility of saline infusion sonohysterography.  

Science.gov (United States)

The introduction of saline infusion sonohysterography has significantly improved sonographic diagnosis of various endometrial pathologies. This procedure entails instillation of warm saline into the uterine cavity transcervically to provide enhanced visualization of the endometrium during transvaginal ultrasound examination. This article reviews the sonohysterography technique and current utility, as well as the spectrum of imaging features of various endometrial pathologies. PMID:19232599

Elsayes, Khaled M; Pandya, Amit; Platt, Joel F; Bude, Ronald O

2009-04-01

164

Treatment of bladder carcinoma with concomitant infusion chemotherapy and irradiation  

International Nuclear Information System (INIS)

In an attempt to increase tumor clearance and bladder preservation without increased morbidity, a pilot study using irradiation and concomitant continuous 5-FU infusion, and Mitomycin C as IV bolus in the treatment of invasive high grade bladder carcinomas was started at Downstate Medical Center. This report shows the preliminary results regarding tumor response, survival, and morbidity of treatment

1986-01-01

165

Animal model of rapid crystalloid infusion in rats  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english PURPOSE: To describe an animal model of rapid intravenous infusion with different volumes of crystalloid and discuss the clinical findings. METHODS: Fifty six male Wistar rats were used, divided randomly in seven groups (n = 8). The rats of groups 1 to 6 received lactated Ringer´s solution intraveno [...] usly, in the rate of 25 ml/min, with different volumes proportional to blood volume (BV). The rats of group 0 were submitted to the same procedure, but did not receive the fluid (control group). The data included respiratory rate, heart rate, saturation of peripheral oxygen (SpO2) in two times (before and after the infusion), and upshots (respiratory arrest and death). Dunnett´s test and ANOVA were used. RESULTS: The clinical signs significantly changed in the 2, 2.5 and 3 fold BV groups. The respiratory arrest was observed in the 1.5, 2, 2.5 and 3 fold BV groups, but death was present only in 2.5 and 3 fold BV groups. CONCLUSIONS: The infusion of crystalloid in the same volume of blood volume did not cause significant variation in respiratory and heart rate, saturation of peripheral oxygen and did not induce respiratory arrest. The infusion of a volume of 3 fold blood volume was lethal to all animals.

Orgaes, Flavio Stillitano; Oliveira Neto, Fausto Viterbo de; Mendes, Flavio Henrique; Yabiku, Renato Florio.

166

Slippery Liquid-Infused Porous Surfaces Showing Marine Antibiofouling Properties  

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Marine biofouling is a longstanding problem because of the constant challenges placed by various fouling species and increasingly restricted environmental regulations for antifouling coatings. Novel nonbiocidal strategies to control biofouling will necessitate a multifunctional approach to coating design. Here we show that slippery liquid-infused porous surfaces (SLIPSs) provide another possible strategy to obtaining promising antifouling coatings. Microporous butyl methacrylate-ethylene dime...

2013-01-01

167

Target-controlled infusion systems: role in anaesthesia and analgesia.  

Science.gov (United States)

Drug delivery by target-controlled infusion (TCI) allows automatic adjustments of the infusion rate of a drug to maintain a desired target concentration. Since drug effect is more closely related to blood concentration than to infusion rate, drug delivery via TCI is capable of creating stable blood concentrations of intravenous anaesthetics and analgesics. In this article the concept and history of TCI are described. The rational administration of TCI requires an appropriate pharmacokinetic data set and knowledge of the concentration-effect relationship; therefore, general pharmacokinetic and pharmacodynamic aspects of intravenous anaesthetics and analgesics are also addressed. Intraoperative investigations have demonstrated that TCI drug delivery allows rapid titration to a desired effect. The use of TCI for postoperative analgesia is still experimental, but TCI can, in part, overcome the disadvantages associated with continuous infusions and patient-controlled analgesia regimens in the postoperative period. Although TCI is capable of creating stable blood concentrations, when the target concentration is changed the resulting effect correlates better with a theoretical effect site concentration. The efficacy of TCI systems that can perform effect-site steering are still to be explored. PMID:10709777

van den Nieuwenhuyzen, M C; Engbers, F H; Vuyk, J; Burm, A G

2000-02-01

168

Prostacyclin infusion may prevent secondary damage in pericontusional brain tissue  

DEFF Research Database (Denmark)

Prostacyclin is a potent vasodilator, inhibitor of leukocyte adhesion, and platelet aggregation, and has been suggested as therapy for cerebral ischemia. A case of focal traumatic brain lesion that was monitored using intracerebral microdialysis, and bedside analysis and display is reported here. When biochemical signs of cerebral ischemia progressed, i.v. infusion of prostacyclin was started.

Reinstrup, Peter; Nordström, Carl-Henrik

2011-01-01

169

[Prophylactic chemotherapy by regional arterial infusion in resected hepatoma patients].  

Science.gov (United States)

We established risk factors for high post-resectional recurrence in patients with hepatocellular carcinoma (HCC). They included: (1)Vp (+), (2)IM (+), (3)more than 5 cm in diameter of the main tumor, and (4)gross type except single nodular tumor. Seventy HCC patients in this category were divided into two groups. In group 1, 11 patients prophylactically underwent hepatic arterial infusion chemotherapy after liver resection. Chemotherapeutic agents (MMC, 5-FU, ADM, CDDP) with Lipiodol were administered 4 times a year via Infuse-A-port. The remaining 59 cases served as the control without prophylactic infusion. Two-year survival rate was better in prophylactic group (75%) than in the control (46%, p = 0.063). The two-year disease-free survival was significantly improved in group 1 (40%) compared with that in group 2 (26%, p = 0.019). Based on our data, we suggest that prophylactic arterial infusion chemotherapy can be efficacious in alleviating hepatoma recurrence after liver resection. PMID:1326914

Nakashima, K; Kim, Y I; Okada, K; Iwao, Y; Aramaki, M; Kobayashi, M; Aikawa, H; Suzuki, K

1992-08-01

170

Improving Middle School Students' Science Literacy through Reading Infusion  

Science.gov (United States)

Despite recent calls for border crossing between reading and science, few studies have examined the impact of reading infusion in the science curriculum on students' science literacy. In this quasi-experimental study, the authors investigated the effects of an inquiry-based science curriculum that integrated explicit reading strategy instruction…

Fang, Zhihui; Wei, Youhua

2010-01-01

171

Modern Methods of Infusion Therapy in Patients with Shock  

Directory of Open Access Journals (Sweden)

Full Text Available The aim of the investigation is the assessment of the effect of various variant of infusion therapy on the function of organs and systems of patients with hemorrhagic and traumatic shock. Materials and methods. There have been presented the results of the single-blind prospective cohort randomized study (by envelope technique of 219 patients with hemorrhagic and traumatic shock divided into group depending on infusion therapy variant. Results. The use of 6% hydroxyethylated starch colloid solution 200/0.5 in infusion therapy program in patients with II–III degree hemorrhagic and traumatic shock was stated not to contribute to effective correction of hypovolemia and systemic hemodynamicss as well as have the negative effect on hemostasis that causes the severity of multiple organ failure. Meanwhile, the use of 4% oxypolygelatin in these patients appeared to correct systemic hemodynamics and not to contribute to severe organ dysfunctions. The use of balanced crystalloid solution of sterofundin isotonic in contrast to imbalanced solution of normal saline has a positive effect on electrolyte and acid-base composition of blood plasma in infusion therapy of patients with II–III degree hemorrhagic and traumatic shock.

?.?. Girsh

2012-08-01

172

Doing Business with China: Curriculum Internationalisation through an Infusion Method  

Science.gov (United States)

The US apparel and textiles industry operates within an interdependent global system, necessitating workforces competent for day-to-day operations. The US workforce lacks preparedness in working globally; this study tests an infusion method of curriculum internationalisation to enhance students' global understanding. Four cognitive and…

Jin, Byoungho; Swinney, Jane; Cao, Huantian; Muske, Glenn; Nam, Jinhee; Kang, Ji Hye

2011-01-01

173

Animal model of rapid crystalloid infusion in rats  

Directory of Open Access Journals (Sweden)

Full Text Available PURPOSE: To describe an animal model of rapid intravenous infusion with different volumes of crystalloid and discuss the clinical findings. METHODS: Fifty six male Wistar rats were used, divided randomly in seven groups (n = 8. The rats of groups 1 to 6 received lactated Ringer´s solution intravenously, in the rate of 25 ml/min, with different volumes proportional to blood volume (BV. The rats of group 0 were submitted to the same procedure, but did not receive the fluid (control group. The data included respiratory rate, heart rate, saturation of peripheral oxygen (SpO2 in two times (before and after the infusion, and upshots (respiratory arrest and death. Dunnett´s test and ANOVA were used. RESULTS: The clinical signs significantly changed in the 2, 2.5 and 3 fold BV groups. The respiratory arrest was observed in the 1.5, 2, 2.5 and 3 fold BV groups, but death was present only in 2.5 and 3 fold BV groups. CONCLUSIONS: The infusion of crystalloid in the same volume of blood volume did not cause significant variation in respiratory and heart rate, saturation of peripheral oxygen and did not induce respiratory arrest. The infusion of a volume of 3 fold blood volume was lethal to all animals.

Flavio Stillitano Orgaes

2013-04-01

174

Using Cross-Curricular Ideas to Infuse Paralympic Sport  

Science.gov (United States)

The Paralympic Games are the second largest sport event in the world. They occur two weeks after the Olympic Games in the same geographic location and sport venues. Despite the Paralympic Games' longevity, many Americans do not even know they exist. One way to meaningfully share information about this event with people of all ages is to infuse

Tepfer, Amanda T. S.; Lieberman, Lauren J.

2012-01-01

175

Duodenal levodopa infusion in Parkinson's disease--long-term experience.  

Science.gov (United States)

Motor fluctuations in parkinsonian patients can be reduced by intraduodenal infusion of levodopa. Between 1991 and 1998 continuous daytime administration of levodopa through a transabdominal port has been used in 28 very advanced patients over a total period of 1045 months. A stable suspension of levodopa and carbidopa (Duodopa) has been developed. Patients were characterized by early onset, long history of disease and levodopa therapy. The reason for infusion was in all cases related to on-off fluctuations. All patients experienced a general improvement after the introduction of continuous treatment. There have been no severe complications. Six patients have taken the decision to curtail their treatment. The mean daily levodopa consumption has been slightly reduced on infusion as compared to oral therapy. Nine of the first group of patients participating in the new therapy have been regularly evaluated by means of rating scales and movement analyses. Short-term results have already been published and a follow-up showing continued positive effect after 4-7 years of continuous duodenal infusion is presented. PMID:11903087

Nilsson, D; Nyholm, D; Aquilonius, S M

2001-12-01

176

Stability of ondansetron hydrochloride in portable infusion-pump reservoirs.  

Science.gov (United States)

The stability of ondansetron hydrochloride 0.24 and 2 mg/mL when delivered by portable infusion pump at near-body temperature over various time periods was investigated. Nine 100-mL drug reservoirs were prepared, three containing ondansetron hydrochloride 2 mg/mL and six containing ondansetron hydrochloride diluted with 0.9% sodium chloride injection to 0.24 mg/mL. Three of the reservoirs containing the diluted solution were refrigerated for up to 30 days at 3 degrees C before being attached to portable infusion pumps and pumped over 24 hours at 30 degrees C. The remaining six reservoirs were attached to pumps immediately after being filled, and the solutions were delivered for up to 24 hours (the diluted solution; three reservoirs) or up to seven days (the concentrated solution; three reservoirs) at 30 degrees C. Samples were taken initially and periodically and analyzed by high-performance liquid chromatography and with a pH meter. Both the diluted and the concentrated solutions of ondansetron hydrochloride retained at least 95% of the initial drug concentration under all the conditions studied. There was no appreciable change in pH. Ondansetron hydrochloride 0.24 mg/mL was stable when stored for up to 30 days at 3 degrees C and infused over 24 hours at 30 degrees C. Ondansetron hydrochloride 2 mg/mL was stable when infused for up to one week at 30 degrees C. PMID:1388331

Stiles, M L; Allen, L V; Fox, J L

1992-06-01

177

Behavior of Homologous exp 125 I Fibrinogen after Thrombin and Ancrod Infusion in Rabbits.  

Science.gov (United States)

The behavior of radioactively labelled fibrinogen after infusion of thrombin or ancrod is investigated. Common factors and differences in the behaviour of fibrinogen after infusion of these two enzymes, which act proteolytically on the fibrinogen, are dea...

R. Setter

1977-01-01

178

Can infusion tests be recommended for patients with giant hydrocephalus?  

Directory of Open Access Journals (Sweden)

Full Text Available Background : The problem of adequate diagnosis of hydrocephalus followed by administration of an effective treatment has not yet been properly solved. Specifically, this pertains to the decision about the surgical insertion of a flow diverting device. Aims : A lumbar infusion test was used to examine the compensatory parameters of intracranial space in giant hydrocephalus. The early and late results of shunt implantation were analyzed together with complications after surgery. Settings and Design : In-house software was used offline to adjust the dynamic intracranial pressure (ICP response to infusion. Materials and Methods : Nine patients with giant hydrocephalus were the subjects for the study. We analyzed recordings of the response in ICP to the 2 ml/min infusion of saline. We performed computerized identification of outflow resistance and intracranial compliance based on the truncated (30- 100% ICP response and assessed the stability of estimates over time. Eight out of nine patients were shunted. Monitoring of patients was followed for a period of up to 9 months. Results : Five out of eight shunted patients improved within a few days of surgery. During follow-up five patients developed various complications. A definite improvement was noted in four patients. The improvement rate did not correlate with any of the compensatory parameters. Most of the patients studied exhibited a lack of intracranial space reserve, a significantly reduced rate of CSF secretion, and a slightly elevated value of outflow resistance. Conclusions : The infusion test showed itself to be more useful as a way of revealing the compensatory parameters of the intracranial space than as a prognostic tool. The outcome of shunted patients with giant hydrocephalus was uncertain, owing to the relatively high rate of complications. We may therefore suggest that the diagnosis of giant hydrocephalus is a relative contraindication to implantation, as well as to the performance of an infusion test.

Cieslicki Krzysztof

2010-01-01

179

Chronopharmacologic aspects of continuous AcSDKP infusion in mice.  

Science.gov (United States)

Inconsistent results characterized N-acetyl-Ser-Asp-Lys-Pro (AcSDKP or Goralatide) effects upon hematologic proliferation, possibly because its circadian organization had been overlooked. We investigated the circadian changes in AcSDKP disposition in plasma and in bone marrow during continuous infusion and AcSDKP effects upon the circadian rhythms in bone marrow granulomonocytic precursors (CFU-GM) and circulating blood cell counts. One hundred ninety-six male B6D2F1 mice received a constant infusion of AcSDKP (24 microg/ day) or 0.9% NaCl for 7 days, using an osmotic minipump. All mice were synchronized with an alternation of 12 hours of light and 12 hours of darkness for 3 weeks prior to study. Mice were sacrificed on the fifth or seventh infusional day at 3, 9, 15, or 21 hours after light onset (HALO) in order to assess plasma and bone marrow AcSDKP concentrations, CFU-GM, and/or circulating blood cell counts. In control mice, plasma and bone marrow AcSDKP concentrations displayed a circadian rhythm with a maximum level during the dark span, at 21 and 15 HALO respectively, while CFU-GM, leukocyte, lymphocyte, and monocyte counts peaked during early light. Continuous AcSDKP infusion increased fivefold mean plasma AcSDKP level at 3 or 9 HALO, thus inverted its physiologic rhythm and suppressed the CFU-GM peak that normally occurs at these times. This inhibition however, was indirect, because the rhythms in bone marrow AcSDKP concentration were similar with or without AcSDKP infusion. Conversely, mean leukocyte and lymphocyte counts were significantly reduced with AcSDKP infusion, while their circadian rhythms remained unaffected and were amplified. The results indicate that AcSDKP pharmacology displays circadian rhythmicity and warrant the exploration of chronopharmacologic schedules of AcSDKP delivery for further protecting bone marrow against chemotherapy insults. PMID:9923440

Li, X M; Ezan, E; Bindoula, G; Soulard, C; Liu, X H; Deschamps de Paillette, E; Lévi, F

1999-01-01

180

Liquid Resin Infusion process monitoring with embedded superimposed long period and short period Bragg grating sensor.  

Directory of Open Access Journals (Sweden)

Full Text Available We propose here the monitoring of the Liquid Resin Infusion (LRI process for using a superimposed long period (LPG and short period (FBG Bragg grating sensor. Monitoring of such a process is usually made measuring simultaneously temperature and strain by the use of an electro-optical device (FBG-Thermocouple. It has been shown that an applied solicitation is measured by a wavelength shift with a different sensitivity for LPG and FBG; thus strain and temperature influences can be determined separately by measuring corresponding wavelength shifts. The reported configuration is based on the use of these two Bragg gratings types written in the same fibre section, which allows us to discriminate the contributions of the temperature and strain. The sensor is embedded in a composite specimen manufactured by LRI process for monitoring in real time and simultaneously the applied temperature and strain.

Robert L.

2010-06-01

 
 
 
 
181

Using miniature osmotic infusion pumps to maintain tritiated thymidine exposure to cells in culture  

Energy Technology Data Exchange (ETDEWEB)

To provide a constant level of tracer doses of tritiated thymidine to cultured cells during continuous infusion, miniature osmotic infusion pumps were used to provide replacement thymidine. By determining the loss of isotope from the media during nonreplacement, the rate of constant infusion replacement to maintain thymidine levels was calculated. The replacement rates were similar for the three cell lines examined and allowed a standard osmotic pump infusion.

Neely, J.E.; Hake, D.A.

1982-06-01

182

Using miniature osmotic infusion pumps to maintain tritiated thymidine exposure to cells in culture  

International Nuclear Information System (INIS)

To provide a constant level of tracer doses of tritiated thymidine to cultured cells during continuous infusion, miniature osmotic infusion pumps were used to provide replacement thymidine. By determining the loss of isotope from the media during nonreplacement, the rate of constant infusion replacement to maintain thymidine levels was calculated. The replacement rates were similar for the three cell lines examined and allowed a standard osmotic pump infusion

1982-01-01

183

Mineral Analysis the Infusion of Black Tea Samples by Atomic Absorption Spectrometry  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Tea infusion is one of the most popular drinks around the world. Since tea infusion is known to contain several essential nutrients, it is considered a healthy beverage. In this study eight different Iranian brands of tea infusion and eleven brands imported tea infusion samples from another country for Cu, Zn, Mn and Al were determined by flame atomic absorption spectrometry after wet digestion. The results of analysis showed that the extraction rates of minerals from dry black tea to infusio...

Lahiji N.; Tadayon F.; Tamiji F.; Lahiji A. H.

2013-01-01

184

Regulation of iodothyronine deiodinase activity as studied in thyroidectomized rats infused with thyroxine or triiodothyronine  

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To provide new insights into the in vivo regulation of iodothyronine deiodinases in the different tissues of the rat, we have evaluated the effects on these enzymatic activities of T4 or T3 infusions into thyroidectomized rats. Thyroidectomized rats were infused with placebo, T4, or T3. Placebo-infused intact rats served as euthyroid controls. Plasma and samples of cerebral cortex, brown adipose tissue, pituitary, liver, and lung were obtained after 12-13 days of infusion. Plasma TSH, plasma ...

1997-01-01

185

A comparison of three different target-controlled remifentanil infusion rates during target-controlled propofol infusion for oocyte retrieval  

Directory of Open Access Journals (Sweden)

Full Text Available OBJECTIVE: To evaluate the effects of three different target-controlled remifentanil infusion rates during target-controlled propofol infusion on hemodynamic parameters, pain, sedation, and recovery score during oocyte retrieval. METHODS: Sixty-nine women were scheduled for oocyte retrieval. Target-controlled propofol infusion at an effectsite concentration of 1.5 ?g/mL was instituted. The patients were randomly allocated to receive remifentanil at an effect-site concentration of either 1.5 (group I, n = 23, 2 (group II, n = 23 or 2.5 ng/mL (group III, n = 23. Hemodynamic variables, sedation, pain, the Aldrete recovery score, and side effects were recorded. RESULTS: Hemodynamic variables, sedation and pain scores and the number of patients with the maximum Aldrete recovery score 10 min after the procedure were comparable among the groups. The number of patients in group III with the maximum Aldrete recovery score 5 min after the procedure was significantly lower than that in groups I and II. One patient in group II and one patient in group III suffered from nausea. CONCLUSION: Similar pain-free conscious sedation conditions without significant changes in hemodynamic parameters were provided by all three protocols. However, target controlled infusion of remifentanil at 1.5 or 2 ng/mL proved superior at providing early recovery compared to 2.5 ng/mL.

Demet Coskun

2011-01-01

186

Mineralocorticoid receptor in the NTS stimulates saline intake during fourth ventricular infusions of aldosterone.  

Science.gov (United States)

The purpose of this study was to determine whether neurons within the nucleus tractus solitarius (NTS) that express the mineralocorticoid receptor (MR) play a role in aldosterone stimulation of salt intake. Adult Wistar-Kyoto (WKY) rats received microinjections into the NTS of a short-hairpin RNA (shRNA) for the MR, to site specifically reduce levels of the MR by RNA interference (shRNA; n = 9) or scrambled RNA as a control (scRNA; n = 8). After injection of the viral construct, aldosterone-filled osmotic minipumps were implanted subcutaneously and connected to a cannula extending into the fourth ventricle to infuse aldosterone at a rate of 25 ng/h. Before and after surgeries, rats had ad libitum access to normal sodium (0.26%) rat chow and two graduated drinking bottles filled with either distilled water or 0.3 M NaCl. Before the surgeries, basal saline intake was 1.6 ± 0.6 ml in the scRNA group and 1.56 ± 0.6 ml in the shRNA group. Twenty-four days postsurgery, saline intake was elevated to a greater extent in the scRNA group (5.9 ± 1.07 ml) than in the shRNA group (2.41 ± 0.6 ml). Post mortem immunohistochemistry revealed a significant reduction in the number of NTS neurons exhibiting immunoreactivity for MR in shRNA-injected rats (23 ± 1 cells/section) versus scRNA-injected rats (33 ± 2 cells/section; P = 0.008). shRNA did not alter the level of 11-?-hydroxysteroid dehydrogenase type II (HSD2) protein in the NTS as judged by the number of HSD2 immunoreactive neurons. These results suggest that fourth ventricular infusions of aldosterone stimulate saline intake, and that this stimulation is at least in part mediated by hindbrain NTS neurons that express MR. PMID:24259463

Koneru, Bhuvaneswari; Bathina, Chandra Sekhar; Cherry, Brandon H; Mifflin, Steve W

2014-01-01

187

Haemolysis following rapid experimental red blood cell transfusion--an evaluation of two infusion pumps  

DEFF Research Database (Denmark)

The vast majority of infusion pumps used for rapid transfusion of large amounts of blood have never been properly examined regarding their influence on the quality of the red blood cells (RBCs) infused. In this study, we evaluated the effect of two different infusion pumps on the degree of RBC destruction following rapid experimental blood transfusion.

Hansen, Tom Giedsing; Sprogøe-Jakobsen, U

1998-01-01

188

Design of a safer approach to intravenous drug infusions: failure mode effects analysis  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Objectives: A set of standard processes was developed for delivering continuous drug infusions in order to improve (1) patient safety; (2) efficiency in staff workflow; (3) hemodynamic stability during infusion changes, and (4) efficient use of resources. Failure modes effects analysis (FMEA) was used to examine the impact of process changes on the reliability of delivering drug infusions.

Apkon, M.; Leonard, J.; Probst, L.; Delizio, L.; Vitale, R.

2004-01-01

189

Optimisation of drilling equipment for drilling long infusion holes. Optimierung der Bohrausruestung zum Bohren langer Traenkloecher  

Energy Technology Data Exchange (ETDEWEB)

Concentration of the operating points requires compensation for the operating processes to an increasing extent. In coal face infusion intensification of the longwall fusion is a suitable measure. The mechanical engineering had to be optimised for the planned drilling of long infusion holes, which enable longwall infusion ahead of the face from only one gate road without additional measures on the face. (orig.).

Betting, K.; Stockmann, H.W.; Henke, B.

1992-05-14

190

Studies on the subcommissural organ area in the rat: the effects aldosterone infused into the central nervous system  

International Nuclear Information System (INIS)

D-aldosterone (5 ng/?l/hr) was infused for six days into the area of the subcommissural organ (SCO) of conscious rats to test the hypothesis that the SCO and the adrenal zona glomerulosa are related functionally in a negative feedback manner. Aldosterone increased urinary sodium loss and the sodium/potassium ratio. These effects still occurred when cannulae were displaced caudally up to 1 mm from the targeted SCO area. Aldosterone decreased the cross-sectional area of the adrenal medulla without affecting chromaffin cell density. Adrenal content of corticosterone was increased. These effects were highly dependent upon proper cannula placement and were not observed when the tip of the cannula was not in contact with the cerebrospinal fluid of the pineal recess over the rostral two-thirds of the SCO. Aldosterone infused intracerebroventricularly (ivt) into a lateral ventricle had no effect on sodium excretion, adrenal corticosterone concentration or adrenal morphology. After the infusion of radiolabelled aldosterone into the SCO area, the majority of the radioactivity was restricted to an area about 1-2 mm in diameter from the SCO. Iron-dextran injected intraperiotoneally did not accumulate in the SCO; therefore, the blood-brain barrier is intact. It is concluded that the effects of aldosterone were dependent upon the area of the brain in which it was infused. Aldosterone increased sodium excretion by an action in the SCO and/or adjacent structures. A relationship between mineralocorticoids and the adrenal modulla mediated by the SCO is also postulated. With regard to the blood-brain and brain-CSF barriers, the SCO more closely resembles general brain tissue than other circumventricular organs

1985-01-01

191

Technical Sections  

International Nuclear Information System (INIS)

Full text: 1. Detector Construction Laboratory for High Energy Physics. Head: Marek Stodulski, Ph.D., Deputy: Jacek Blocki, Ph.D. Eng. Personnel of 4 research staff members and 9 technical staff . Main subject of activity: design and construction of mechanical structures and cooling systems applied in high energy physics experiments. Includes research, development, prototyping and tests. Presently involved in the installation of the ATLAS experiment and the LHC machine at CERN and in the design of new detectors (ICARUS, CASTOR and LUMICAL) at IFJ PAN. Also, research and development of new materials, such as carbon-carbon (C/C) composites. 2. Mechanical Engineering Section. Head: Jerzy Brzezicki, M.Sc. Eng., Deputy: Krzysztof Wisniewski, M.Sc. Eng. Personnel of 22 people. Activity: design and production of scientific apparatus. Construction of versatile equipment, including, e.g. electrically driven lock in the shield and automatic targets for beam diagnostics for the AIC-144 cyclotron, mechanisms supporting thermoluminescent readers (EU project MAESTRO), design and construction of an equipment for production of elements for ICARUS neutrino experiment (Gran Sasso), and series of equipment constructed for CERN i.e.: periscope instruments for visual inspection of LHC beam (6 items), optical tool for verification of LHC magnet transverse alignment before interconnection (1 item), line N protection covers (100 items), line N handling assembly (100 items), cooling system support (500 items), final production of the series of stesalite elements (? 100 items) for the cooling system of ATLAS experiment. 3. The Cyclotron Division. Head: Jacek Sulikowski, M.Sc. Personnel: 2 research staff members and 14 people of technical staff . Main subject of activity: modernization of the AIC-144 IFJ PAN cyclotron and its adaptation for medical purposes (proton/neutron radiotherapy, production of radioisotopes).Th is program includes extraction of 60 MeV proton and hellions and 30 MeV deuteron beams, purchase, installation and putting into operation of the new magnet power supply and the new PIG ion source. During last two years period we completed the modernization of the experimental hall No.1 and rebuilt the system of the beam transport lines. The proton beam was delivered to the box for an eye melanoma treatment. We have also continued the efforts on the analytical computer programme HELP for the calculation of main parameters of the beam dynamics (in cooperation with JINR Dubna). (author)

2007-01-01

192

Aluminum Contents in Dry Leaves and Infusions of Commercial Black and Green Tea Leaves: Effects of Sucrose and Ascorbic Acid Added to Infusions  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Tea consumption has increased due to its beneficial effects. Results from a lab study on the effect of sucrose (5 g per cup, 150 mL) and/or ascorbic acid (2 mL per cup, 150 mL) on dissolved aluminum compounds during the infusion of two commercial types of dry tea leaves (black, green) with boiling water (5, 15 min infusion time) are presented. Factors influencing the presence of dissolved aluminum in the infusions of both tea leaves were infusion time and sugar contents, as well as the intera...

Diego Armando Bárcena-Padilla; Marisela Bernal-González; Amalia Panizza-de-León; Rolando Salvaor García-Gómez; Carmen Durán-Domínguez-de-Bazúa

2011-01-01

193

Combined radiosensitizer infusion and irradiation of osteogenic sarcomas  

International Nuclear Information System (INIS)

Three children with osteogenic sarcomas which were either unresectable or whose parents refused permission to amputate were treated with combined intra-arterial 5'bromodeoxyuridine (BUdR) infusion and high-dose-per-fraction megavoltage irradiation to the primary site. Pulsed, 48-hour BUdR infusions were performed prior to each 600-rad radiation therapy fraction, with a total radiation dose to the primary site of 4,200 to 4,800 rads in five weeks. Local control was obtained in all 3 children. One child is alive two years after treatment, another died with metastatic disease, and the third patient who received radiotherapy to the lungs for pulmonary metastases is without evidence of disease one year later. (auth)

1975-01-01

194

Anisomycin infusions in the parabrachial nucleus and taste neophobia.  

Science.gov (United States)

To investigate whether de novo protein synthesis in the parabrachial nucleus (PBN) is required for recovery from taste neophobia, anisomycin (a protein synthesis inhibitor) was infused immediately after consumption of a novel saccharin solution (Experiment 1). Unexpectedly, this PBN treatment caused a reduction in saccharin intake. In addition, we found that the anisomycin-induced suppression of tastant intake was attenuated by prior intra-PBN infusions of lidocaine (Experiment 2). This pattern of results raises concerns about using anisomycin to investigate memory consolidation processes in the PBN. Thus, a different manipulation may be needed to examine the nature of the neuroplastic changes that occur in the PBN during taste memory formation. PMID:23063932

Lin, Jian-You; Amodeo, Leslie Renee; Arthurs, Joe; Reilly, Steve

2012-11-01

195

Internal mammary arterial infusion therapy for chest diseases  

International Nuclear Information System (INIS)

Objective: To study the value of interventional therapy for chest diseases via internal mammary artery (IMA) and the features of internal mammary artery angiography. Methods: 31 cases of different chest diseases were undertaken the angiography and interventional therapy through IMA. Results: The lesions of 31 cases were supplied by internal mammary artery partly or totally. The good therapeutic effectiveness was achieved in 20 cases with pulmonary carcinoma. The masses and the enlarged lymph nodes were shrunk obviously in 4 cases of advanced breast carcinoma and one of them was cured with operation after internal mammary arterial infusion. One case of low invasive thymoma was cured by internal mammary arterial infusion combined with resection. The bleeding was stopped absolutely after IMA embolization in 6 cases of hemoptysis (bronchiectasis in 2 cases, pulmonary tuberculosis in 4 cases). Conclusions: The interventional therapy via IMA is very important and necessary when the mass in the chest is supplied by IMA. (authors)

2004-12-01

196

Infusing Disability Sport into the Sport Management Curriculum  

Directory of Open Access Journals (Sweden)

Full Text Available Disability sport is growing around the world with momentum and is described as a “movement” (Bailey, 2008; DePauw & Gavron, 2005. While there are more similarities than differences with sport management for able-bodied athletes and those with disabilities, there are additional needs and considerations for persons with disabilities (DePauw & Gavron, 2005. The noticeable visibility of individuals with disabilities in society, including sport, raises concerns about the degree to which sport management academic programs have modified their curricula to ensure that individuals working in the sport management field are prepared to deal with theuniqueness of disability sport. This paper (a discusses theoretical perspectives toward understanding and thinking about disability, (b explores ways to enhance sport management curricula through infusion of disability sport, (c reflects upon current social practices for curriculum integration of athletes with disabilities in sport, and (d acknowledges infusion of disability sport businesses, organizations and events.

Jimmy Calloway

2012-01-01

197

Abnormal thallium 201 scintigraphy during low-dose vasopressin infusions  

Energy Technology Data Exchange (ETDEWEB)

Thallium 201 (/sup 201/Tl) myocardial scans were obtained in 16 patients just prior to the discontinuation of a vasopressin infusion (.1 to .2 units/min) administered for the treatment of upper gastrointestinal bleeding. Repeat scintigraphy was performed two to three hours after the vasopressin was stopped. Eleven of the 16 patients (69 percent) demonstrated areas of decreased myocardial /sup 201/Tl uptake that resolved after the infusion was stopped. Heart rate-blood pressure product was significantly lower at the time of the second scan. Autopsies were secured in three of 11 scan-positive patients: one had severe coronary artery obstruction, one nonsignificant disease, and another had normal coronary arteries. Vasopressin, even at low doses, can induce abnormalities in myocardial perfusion that are probably mediated by a direct effect on the coronary circulation. They are usually not detectable by routine monitoring techniques and conceivably form the basis for the cardiovascular morbidity associated with the use of this agent.

Davison, R.; Kaplan, K.; Bines, A.; Spies, S.; Reed, M.T.; Lesch, M.

1986-12-01

198

A Fast Technology Infusion Model for Aerospace Organizations  

Science.gov (United States)

A multi-year Fast Technology Infusion initiative proposes a model for aerospace organizations to improve the cost-effectiveness by which they mature new, in-house developed software and hardware technologies for space mission use. The first year task under the umbrella of this initiative will provide the framework to demonstrate and document the fast infusion process. The viability of this approach will be demonstrated on two technologies developed in prior years with internal Jet Propulsion Laboratory (JPL) funding. One hardware technology and one software technology were selected for maturation within one calendar year or less. The overall objective is to achieve cost and time savings in the qualification of technologies. At the end of the recommended three-year effort, we will have demonstrated for six or more in-house developed technologies a clear path to insertion using a documented process that permits adaptation to a broad range of hardware and software projects.

Shapiro, Andrew A.; Schone, Harald; Brinza, David E.; Garrett, Henry B.; Feather, Martin S.

2006-01-01

199

Rare, potentially fatal, poorly understood propofol infusion syndrome  

Directory of Open Access Journals (Sweden)

Full Text Available We present the case of a 7-year old boy with traumatic brain injury who received propofol during 38 h. Thirty-six hours after cessation of propofol infusion asystole occurred. After immediate mechanical and medical resuscitation, unreactive dilated pupils were observed. The following computed tomography scan revealed a generalized brain edema with transtentorial herniation. Prolonged bradyarrhythmia, rhabdomyolysis, and peracute renal failure were observed. Despite immediate craniectomy, barbiturate treatment, hemofiltration, and recovery of appropriate cardiac function, the patient died four days after discontinuation of propofol. In this case, metabolic acidosis, cardiac failure, rhabdomyolysis, and renal failure are in accordance with the symptoms of propofol infusion syndrome (PRIS, while seizure, brain edema, and transtentorial herniation could be caused by traumatic brain injury. However, it may be assumed that the entire clinical picture was caused by PRIS. This view could be explained by a common loss of function of ryanodine receptors in patients presenting with PRIS.

Albert Urwyler

2012-05-01

200

Intraventricular baclofen infusion for dystonia. Report of two cases.  

Science.gov (United States)

Two children with generalized dystonia were given continuous intraventricular baclofen (IVB) infusions. The first was a 12-year-old girl with mixed dystonia and spasticity caused by methylmalonic aciduria whose spinal anatomy precluded administration of intrathecal baclofen (ITB). The second was an 11-year-old boy whose dystonia was associated with cerebral palsy and had not improved significantly in response to conventional ITB treatment. The girl improved dramatically with IVB; the boy experienced no greater improvement from IVB than from ITB. No adverse effects were noted in either child during 2 to 6 months of infusion. These are the first reports of the use of IVB in this clinical setting. The results warrant additional investigation. PMID:16871874

Albright, A Leland

2006-07-01

 
 
 
 
201

Adenosine infusion increases plasma levels of VEGF in humans  

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Abstract Background Many in vitro studies have shown that adenosine (Ado) can induce vascular endothelial growth factor (VEGF) mRNA and protein expression and stimulate endothelial proliferation. In the present study, we seek to determine whether Ado can increase circulating levels of VEGF protein in the intact human. Methods Five outpatients 49.3 ± 6.7 years of age and weighing 88.2 ± 8.5 kg were selected. They were given a 6 min intravenous infusion...

Adair Thomas H; Cotten Reid; Gu Jian-Wei; Pryor Janelle S; Bennett Kenneth R; McMullan Michael R; McDonnell Preston; Montani Jean-Pierre

2005-01-01

202

Pethidine clearance during continuous intravenous infusions in postoperative patients.  

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1 Pethidine pharmacokinetics in ten female patients during continuous i.v. infusion for 32 h post-surgery have been determined. 2 The blood clearance of pethidine (mean +/- 2.d.) measured directly was 599 +/- 135 ml/min and is in marked contrast to some reported values. 3 Other model-dependent pharmacokinetic parameters were consistent with previously reported values. 4 Pethidine and indocyanine green clearance were correlated but the correlation was mediated through body weight. 5 Pethidine ...

Austin, K. L.; Stapleton, J. V.; Mather, L. E.

1981-01-01

203

Saline infusion sonohysterography versus hysteroscopy for uterine cavity evaluation  

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Background and Objectives: The most frequent procedures performed on women with abnormal uterine bleeding are 2D and 3D ultrasound. The most common accepted approach for the management of abnormal uterine bleeding is 2D TV scan followed by therapeutic hysteroscopy. The purpose of this prospective study was to assess whether 3D saline infusion sonohysterography (3D SIS) could replace diagnostic hysteroscopy (DH) for the diagnosis of endometrial pathology, in patients with abnormal uteri...

2011-01-01

204

Can infusion tests be recommended for patients with giant hydrocephalus?  

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Background : The problem of adequate diagnosis of hydrocephalus followed by administration of an effective treatment has not yet been properly solved. Specifically, this pertains to the decision about the surgical insertion of a flow diverting device. Aims : A lumbar infusion test was used to examine the compensatory parameters of intracranial space in giant hydrocephalus. The early and late results of shunt implantation were analyzed together with complications after surgery. ...

Cieslicki Krzysztof; Czepko Ryszard

2010-01-01

205

Hepatic Arterial Infusion Chemotherapy for Advanced Hepatocellular Carcinoma in Japan  

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Transcatheter methods such as transcatheter arterial chemoembolization (TACE) and hepatic arterial infusion chemotherapy (HAIC) have an important role in the treatment for advanced hepatocellular carcinoma (HCC). Recently, sorafenib, an inhibitor of tyrosine kinases, has been found to obtain survival benefits in patients with HCC, leading to major advances in the treatment of advanced HCC. However, it is associated with a low tumor response rate, minimal survival advantage, and high rates of ...

Hiroki Nishikawa; Yukio Osaki; Ryuichi Kita; Toru Kimura

2012-01-01

206

Cardiovascular effects of intravenous ghrelin infusion in healthy young men  

DEFF Research Database (Denmark)

Ghrelin infusion improves cardiac function in patients suffering from cardiac failure, and bolus administration of ghrelin increases cardiac output in healthy subjects. The cardiovascular effects of more continuous intravenous ghrelin exposure remain to be studied. We therefore studied the cardiovascular effects of a constant infusion of human ghrelin at a rate of 5 pmol/kg per minute for 180 min. Fifteen healthy, young (aged 23.2 +/- 0.5 yr), normal-weight (23.0 +/- 0.4 kg/m(2)) men volunteered in a randomized double-blind, placebo-controlled crossover study. With the subjects remaining fasting, peak myocardial systolic velocity S', tissue tracking TT, left ventricular ejection fraction EF, and endothelium-dependent flow-mediated vasodilatation were measured. Ghrelin infusion increased S' 9% (P = 0.002) and TT 10% (P <0.001), whereas EF, resting blood flow velocity, and endothelium-dependent flow-mediated vasodilatation did not change (P = 0.13). This was associated with a peak in serum growth hormone after 60 min of infusion (37.77 +/- 5.27 ng/ml, P <0.001), a doubling of free fatty acid levels (P = 0.001), and a 1.6-fold increase in cortisol levels (P <0.05), whereas glucose and catecholamine levels were constant. In conclusion, supraphysiological levels of ghrelin stimulate left ventricular function in terms of S' and TT in healthy young normal-weight men without changing resting blood flow velocity and endothelium-dependent flow-mediated vasodilatation. The effects did not translate into detectable increments in EF.

Vestergaard, Esben Thyssen; Andersen, Niels Holmark

2007-01-01

207

A pharmacokinetic-pharmacodynamic model for duodenal levodopa infusion  

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Objective Levodopa in presence of decarboxylase inhibitors is following two-compartment kinetics and its effect is typically modelled using sigmoid Emax models. Pharmacokinetic modelling of the absorption phase of oral distributions is problematic because of irregular gastric emptying. The purpose of this work was to identify and estimate a population pharmacokinetic- pharmacodynamic model for duodenal infusion of levodopa/carbidopa (Duodopa®) that can be used for in numero simulation of tre...

2007-01-01

208

Ist die subkutane Infusion eine praktische Alternative in der Geriatrie?  

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In der Geriatrie hat das Thema der Flüssigkeitssubstitution einen besonderen Stellenwert - so verwundert es nicht, daß hauptsächlich Geriater die subkutane Infusion als Methode der Flüssigkeitszufuhr für ihre Patienten wiederentdeckten. Sie gilt heute als einfach, komplikationsarm, sicher und vor allem als für den Patienten schonend. Sie hat viele Vorteile und nur wenige Nachteile. Ihre Domäne ist die Vorbeugung von Dehydratation in Situationen, die dafür ein Risiko darstellen, sowie ...

2001-01-01

209

Paradoxical hypotension during dobutamine infusion for myocardial perfusion scintigraphy  

International Nuclear Information System (INIS)

Dobutamine as a predominant beta-1 agonist increases heart rate and myocardial contractility and at sufficient high doses, it also increases systolic blood pressure. This study was undertaken to describe instances of paradoxical hypotension during dobutamine infusion for Tl-201 myocardial perfusion SPECT study and the relationship between scintigraphic findings and hypotension occurred during dobutamine infusion. Methods: In 201 consecutive patients unable to perform adequate exercise, dobutamine Tl-201 myocardial SPECT was performed. Dobutamine was infused starting from 10 ?g/kg/min increasing to 40 ?/kg/min. Paradoxical hypotension was defined as a decrease in systolic blood pressure ? 20 mmHg compared with baseline study. Paradoxical hypotension was observed in 40 patients (Group A) out of 201 (19.9%) while no significant change in systolic blood pressure was detected in the remaining 161 patients (Group B). Mean maximum fall in systolic blood pressure was 39±18 mmHg (range: 20-90). In 33 of 40 patients (83%) with paradoxical hypotension, scintigraphy was normal compared to 131 (81%) of the remaining 161 patients. In patients of Group A, angiography, echocardiography and tilt table tests were performed in 13, 11 and 6 patients respectively. Nine of 13 angiographic evaluations (69%), 10 of 11 echocardiographic evaluations (91%), all of the tilt table tests were normal. Additionally, all of the patients of Group A were clinically followed up at least 6 months after the myocardial perfusion scintigraphy. None of the patients had a cardiac event except one patient during the follow-up period. Conclusion: Paradoxical hypotension during dobutamine infusion for myocardial scintigraphy is not an uncommon finding and up to 19.9% patients may develop such hypotension. To maximize test safety, precautions should be taken during dobutamine myocardial stress test, since remarkable decrease in systolic blood pressure may occur. Unlike hypotension occurring with exercise test, hypotension response to dobutamine is not always a marker for coronary artery disease. (orig.)

1998-01-01

210

Effect of magnesium infusion on thoracic epidural analgesia  

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Introduction: Patients of lung volume reduction surgery (LVRS) having an ASA status III or more are likely to be further downgraded by surgery to critical levels of pulmonary function. Aim: To compare the efficacy of thoracic epidural block with (0.125%) bupivacaine, fentanyl combination and (0.125%) bupivacaine, fentanyl combination with adjunctive intravenous magnesium infusion for the relief of postoperative pain in patients undergoing LVRS. Methods: Pati...

Gupta Sampa; Mitra Koel; Mukherjee Maitreyee; Roy Suddhadeb; Sarkar Aniruddha; Kundu Sudeshna; Goswami Anupam; Sarkar Uday; Sanki Prakash; Mitra Ritabrata

2011-01-01

211

Reactive hypoglycaemia following GLP-1 infusion in pancreas transplant recipients  

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The aim of the study was to determine whether reactive hypoglycaemia in pancreas transplant recipients that followed administration of glucagon-like peptide-1 (GLP-1) was associated with excessive insulin, insufficient glucagon, or both. Methodology involved six portally drained pancreas recipients who received GLP-1 (1.5 pmol/kg/min) or placebo infusion on randomized occasions during glucose-potentiated arginine testing. The second subject developed symptomatic hypoglycaemia [plasma glucose ...

Rickels, M. R.; Naji, A.

2010-01-01

212

Regional blood flow during continuous low-dose endotoxin infusion  

International Nuclear Information System (INIS)

Escherichia coli endotoxin (ET) was administered to adult rats by continuous IV infusion from a subcutaneously implanted osmotic pump (Alzet). Cardiac output and regional blood flow were determined by the radiolabeled microsphere method after 6 and 30 hr of ET or saline infusion. Cardiac output (CO) of ET rats was not different from time-matched controls, whereas arterial pressure was 13% lower after 30 hr of infusion. After both 6 and 30 hr of ET, pancreatic blood flow and percentage of cardiac output were lower than in controls. Estimated portal venous flow was decreased at each time point, and an increased hepatic arterial flow (significant after 30 hr) resulted in an unchanged total hepatic blood flow. Blood flow to most other tissues, including epididymal fat, muscle, kidneys, adrenals, and gastrointestinal tract, was similar between treatments. Maintenance of blood flow to metabolically important tissues indicates that the previously reported alterations in in vitro cellular metabolism are not due to tissue hypoperfusion. Earlier observations of in vitro myocardial dysfunction, coexistent with the significant impairment in pancreatic flow, raise the possibility that release of a myocardial depressant factor occurs not only in profound shock but also under less severe conditions of sepsis and endotoxemia

1986-01-01

213

A Successful Infusion Process for Enabling Lunar Exploration Technologies  

Science.gov (United States)

The NASA Vision for Space Exploration begins with a more reliable flight capability to the International Space Station and ends with sending humans to Mars. An important stepping stone on the path to Mars encompasses human missions to the Moon. There is little doubt throughout the stakeholder community that new technologies will be required to enable this Vision. However, there are many factors that influence the ability to successfully infuse any technology including the technical risk, requirement and development schedule maturity, and, funds available. This paper focuses on effective infusion processes that have been used recently for the technologies in development for the lunar exploration flight program, Constellation. Recent successes with Constellation customers are highlighted for the Exploration Technology Development Program (ETDP) Projects managed by NASA Glenn Research Center (GRC). Following an overview of the technical context of both the flight program and the technology capability mapping, the process is described for how to effectively build an integrated technology infusion plan. The process starts with a sound risk development plan and is completed with an integrated project plan, including content, schedule and cost. In reality, the available resources for this development are going to change over time, necessitating some level of iteration in the planning. However, the driving process is based on the initial risk assessment, which changes only when the overall architecture changes, enabling some level of stability in the process.

Over, Ann P.; Klem, Mark K.; Motil, Susan M.

2008-01-01

214

iPRECIO® Micro Infusion Pump: Programmable, refillable and implantable  

Directory of Open Access Journals (Sweden)

Full Text Available Successful drug delivery using implantable pumps may be found in over 12,500 published articles. Their versatility in delivering continuous infusion, intermittent or complex infusion protocols acutely or chronically has made them ubiquitous in drug discovery and basic research. The recent availability of iPRECIO®, a programmable, refillable and implantable infusion pump has made it possible to carry out quantitative pharmacology (PKPD in single animals. When combined with specialized catheters, specific administration sites have been selected. When combined with radiotelemetry, the physiologic gold standard, more sensitive and powerful means of detecting drug induced therapeutic and/or adverse effects has been possible. Numerous application examples are cited from iPRECIO® use in Japan, United States and Europe with iPRECIO® as an enabling drug delivery device where the refillable and programmability functionality were key benefits. The ability to start/stop drug delivery and to have control periods prior dosing made it possible to have equivalent effects at a much lower dose than previously studied. Five different iPRECIO® applications are described in detail with references to the original work where the implantable, refillable and programmable benefits are demonstrated with their different end-points.

TsungTan

2011-07-01

215

Duodenal levodopa infusion for the treatment of Parkinson's disease.  

Science.gov (United States)

Motor fluctuations are a common problem in the long-term management of Parkinson's disease (PD), resulting in disability and impaired quality of life. The relatively short serum half-life (approximately 90 min) of oral levodopa/carbidopa and its erratic absorption due to delayed and inconsistent gastric emptying (a non-motor feature of PD) are thought to be important factors in the development of motor fluctuations. Continuous infusion of levodopa/carbidopa directly into the small intestine of PD patients results in marked reduction of motor fluctuations by reducing plasma levodopa variability by an order of magnitude over oral therapy. Previously, the use of long-term intraduodenal infusion of levodopa/carbidopa was limited by the relatively large volumes of infusate necessitated by the low solvency of levodopa. The development of a micronized levodopa (20 mg/ml) and carbidopa (5 mg/ml) suspension utilizing a methylcellulose gel provides the high levodopa concentration and physical and chemical stability necessary for long-term enteral therapy. Clinical evidence indicates that a marked reduction of motor fluctuations and dyskinesias can be achieved and maintained by intraduodenal administration of this suspension. This article reviews the published data describing the efficacy and safety of duodenal levodopa, and discusses its current and potential role in meeting the needs of PD patients. PMID:17376020

Samanta, Johan; Hauser, Robert A

2007-04-01

216

Intracranial hemodynamics during intravenous infusion of glyceryl trinitrate  

DEFF Research Database (Denmark)

The mechanisms of glyceryl trinitrate (GTN)-induced headache are not fully elucidated. In this study we administered GTN 0.5 microg/kg/min i.v. for 20 min in six healthy volunteers. Before, during and 60 min after the infusion, we investigated regional cerebral blood flow (rCBF), cerebral blood volume (CBV), both estimated with SPECT, and blood flow velocity (BFV) in the middle cerebral artery (MCA), measured with transcranial Doppler. Headache was scored on a numerical verbal rating (0-10) scale. rCBF was unchanged, CBV was slightly increased (13%) during GTN infusion, whereas BFV decreased both during (20%) and 60 min (15%) after GTN. Headache was short-lived and maximal during infusion. This discrepancy of time-effect curves for the effect of GTN on headache and dilatation of MCA indicates that MCA is most likely not the primary source of pain in GTN-induced headache. The time-effect curves for the effect of GTN on headache and on dilation of MCA differed markedly. This indicates that MCA is most likely not the primary source of pain in GTN-induced headache Udgivelsesdato: 2008/6

Iversen, H.K.; Holm, S.

2008-01-01

217

Fat overload syndrome after the rapid infusion of SMOFlipid emulsion.  

Science.gov (United States)

Fat overload syndrome is a well-known complication of intravenous lipid emulsion therapy. It is characterized by headaches, fever, jaundice, hepatosplenomegaly, respiratory distress, and spontaneous hemorrhage. Other symptoms include anemia, leukopenia, thrombocytopenia, low fibrinogen levels, and coagulopathy. Several reports in the literature describe fat overload syndrome caused by rapid infusion of lipid emulsions, all with soybean-based lipid emulsions. We report fat overload syndrome in a 2-year-old girl with short bowel syndrome on home parenteral nutrition. Fat overload syndrome occurred as a result of accidental, very rapid infusion of a 20% soy oil, medium-chain triglyceride, olive and fish oil-based lipid emulsion (SMOFlipid) that showed the same complications seen with an earlier lipid emulsion (Intralipid). The patient was successfully treated with supportive care combining fluid infusion, transfusion of platelets, and substitution of serum albumin (0.5 g/kg/d) and fresh-frozen plasma (10 mL/kg). In the next couple of days, she received extra platelets, erythrocyte transfusion, and filgrastim (Neupogen; 5 µg/kg/d) due to a very low leukocyte count. To the best of our knowledge, this is the first case of fat overload syndrome caused by SMOFlipid emulsion described in the literature. PMID:23520135

Hojsak, Iva; Kola?ek, Sanja

2014-01-01

218

Review of pharmacokinetic models for target controlled infusions in anesthesia  

Directory of Open Access Journals (Sweden)

Full Text Available Intravenous injection of anesthetic drugs dates back to the 17th Century when opium and chloral hydrate have been injected intravenously. It was not until the 1930s intravenous anesthesia became popular with the invention of barbiturates.Early intravenous anesthetic agents such as barbiturates were ideal for induction of anesthesia, but not suitable for maintenance of anesthesia. Most of these drugs accumulated significantly with increasing durations of infusion and also resulted in cardiorespiratory depression. The invention of propofol and shorter acting opioid analgesics such as remifentanil and alfentanil have revolutionized intravenous anesthesia. The rapid onset and offset of these drugs lends itself to being suitable agents for maintenance of anesthesia over prolonged periods of time. Detailed understanding of the pharmacokinetics of propofol and remifentanil, combined with technological advances in intravenous pumps capable of accurate delivery of drugs have resulted in great development of the field of total intravenous anesthesia and target controlled infusions. I would like to discuss, in this article, the pharmacokinetics and pharmacokinetic models behind these intravenous infusion pumps. [Int J Basic Clin Pharmacol 2014; 3(3.000: 417-423

Subash Kennedy Sivasubramaniam

2014-06-01

219

Effect of infusible carbonaceous additives on coking coal fusibility  

Energy Technology Data Exchange (ETDEWEB)

Infusible materials are often included in the formulation of coking coal blends in order to modify the fissuring behaviour of the product coke, to meet ash specifications, or as cheapening agents. It is well known, and intuitively obvious, that the addition of infusible material will reduce the fusibility of the blend. However, because the commonly used tests of coal fusibility, such as Gieseler plastometry, Audibert-Arnu dilatometry and crucible swelling number, are empirically based, there has been little attempt to derive and test theoretical models that aim to predict the expected reduction in fusibility on addition of inert materials. Thus there have been no fluidity or related studies of possible interactions between blend components that could modify the thermoplastic behaviour of the blend. Proton magnetic resonance thermal analysis (PMRTA) measures the extent and degree to which a material is fused during heating to temperatures of up to 600{degrees}C. Because it is a quantitative technique, the behaviour of mixtures of materials can be predicted from a knowledge of the behaviour of the components. Discrepancies between the predicted and measured results for mixtures thus indicate interactions between the components. This paper describes a PMRTA and dilatometry study of the effect of blending a series of infusible materials (including petroleum coke, semi-anthracite and charcoal) with a coal on its thermoplastic behaviour.

Sakurovs, R.; Burke, L.; Tyler, R.J. [CSIRO, North Ryde (Australia)

1995-12-31

220

Local Intraarterial Thrombolysis: In Vitro Comparison of Various Infusion Catheters  

International Nuclear Information System (INIS)

Purpose: Catheters are compared in vitro to evaluate the efficacy of thrombolysis during urokinase infusion within the thrombus. Methods: Six catheters were introduced individually into human thrombus within a stenotic flow model. Urokinase was infused continuously into the thrombus. To quantify the efficacy of thrombolysis, pressure gradients were recorded proximal and distal to the thrombus and during the course of infusion. Uniformity of lysis was assessed radiographically. Results: The fastest and most homogeneous thrombolysis was achieved with the EDM and the straight-flush catheter, shown by decreasing transthrombotic pressure gradients. All other catheter designs showed less homogeneous and delayed thrombolysis (p? 0.001, Friedmann-Test, Schaich-Hamerle). There was no significant difference in the efficacy of thrombus dissolution between the EDM and the straight-flush catheter (Wilcoxon, matched pairs, p> 0.7). Conclusion: The EDM catheter and the straight flush catheter achieved the most homogeneous and fastest thrombolysis, apparently due to the best urokinase distribution within the thrombus

1997-09-01

 
 
 
 
221

Preliminary results of a randomized study of intrahepatic infusion versus systemic infusion of FUDR for metastatic colorectal carcinoma  

International Nuclear Information System (INIS)

This paper presents a randomized study that compares intrahepatic infusion to systemic infusion applying the same chemotherapeutic agent (FUDR), schedule, and method of administration. Radiation therapy patients with measurable metastatic colorectal carcinoma to the liver, without extrahepatic disease, are eligible. Patients with a Karnofsky Performance Status less than 60% and a serum bilirubin greater than 4.0 mg/d1 are excluded. To date, 11 partial responses (PR's) in 26 evaluable patients were seen in the intrahepatic group and 8 PR's in 24 evaluable patients in the systemic group. The median duration of response is 7 months for both groups. There were two minor responses in each group. In the systemic group, 3 patients have stable disease for 4-13+ months. Fifteen patients in the intrahepatic group and 10 patients in the systemic group have had more than 50% reduction in carcinoembryonic antigen level

1986-01-01

222

The analgesic and sedative properties of dexmedetomidine infusion after uvulopalatopharyngoplasty  

Directory of Open Access Journals (Sweden)

Full Text Available Background: Dexmedetomidine is an alpha2 - adrenergic agonist with sedative and analgesic properties. This study aimed to investigate if the use of continuous dexmedetomidine infusion with i.v. morphine patient-controlled analgesia (PCA could improve postoperative analgesia while reducing opioid consumption and opioid-related side effects. Materials & methods: In this prospective randomized, double-blinded, controlled study, 24 patients with obstructive sleep apnea syndrome undergoing uvulopalatopharyngoplasty were assigned to two groups. Group D received a loading dose of dexmedetomidine 1µg kg¯¹ i.v., 30 min before the anticipated end of surgery, followed by a continuous infusion at a rate of 0.6 µg kg¯¹ hr¯¹ for 24 hr. Group P received a volume-matched bolus and infusion of placebo. In both groups, postoperative pain was initially controlled by i.v. morphine titration and then PCA with morphine. Cumulative PCA morphine consumption, pain intensities, sedation scores, cardiovascular and respiratory variables and narcotic-related adverse effects were recorded for 48 h after operation. Results: Extubation time was significantly prolonged in dexmedetomidine group (16±7 vs. 11±6 min p=0.074 in the placebo group. Visual analogue scale scores were significantly greater during the first 2h after tracheal extubation in the placebo group than in the dexmedetomidine group. The time to first analgesic request was significantly longer in the dexmedetomidine group than in the placebo group (21±11 vs. 9±4min; p=0.002. Compared with group P, patients in group D required 52.7% less morphine by PCA during the first 24h postoperative period, whereas levels of sedation were similar between the 2 groups at each observational time point. Fewer patients in group D experienced nausea and vomiting than those in group P (P< 0.05. There was no bradycardia, hypotension, or respiratory depression. Continuous dexmedetomidine infusion may be a useful anesthetic adjuvant for patients who are susceptible to narcotic-induced respiratory depression. Conclusion: Continuous infusion of dexmedetomidine for pain relief after uvulopalatopharyngoplasty significantly reduces the amount of PCA morphine used by the patients postoperatively without affecting their ventilatory parameters and was associated with fewer morphine-related side effects. This novel drug could become a useful anesthetic adjuvant for patients with obstructive sleep apnea who are susceptible to narcotic-induced respiratory depression

W.Abd El Megid ¹* and Ahmed M. Nassar

2009-09-01

223

RF tumor ablation with internally cooled electrodes and saline infusion: what is the optimal location of the saline infusion?  

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Full Text Available Abstract Background Radiofrequency ablation (RFA of tumors by means of internally cooled electrodes (ICE combined with interstitial infusion of saline may improve clinical results. To date, infusion has been conducted through outlets placed on the surface of the cooled electrode. However, the effect of infusion at a distance from the electrode surface is unknown. Our aim was to assess the effect of perfusion distance (PD on the coagulation geometry and deposited power during RFA using ICE. Methods Experiments were performed on excised bovine livers. Perfusion distance (PD was defined as the shortest distance between the infusion outlet and the surface of the ICE. We considered three values of PD: 0, 2 and 4 mm. Two sets of experiments were considered: 1 15 ablations of 10 minutes (n ? 4 for each PD, in order to evaluate the effect of PD on volume and diameters of coagulation; and 2 20 additional ablations of 20 minutes. The effect of PD on deposited power and relative frequency of uncontrolled impedance rises (roll-off was evaluated using the results from the two sets of experiments (n ? 7 for each PD. Comparisons between PD were performed by analysis of variance or Kruskal-Wallis test. Additionally, non-linear regression models were performed to elucidate the best PD in terms of coagulation volume and diameter, and the occurrence of uncontrolled impedance rises. Results The best-fit least square functions were always obtained with quadratic curves where volume and diameters of coagulation were maximum for a PD of 2 mm. A thirty per cent increase in volume coagulation was observed for this PD value compared to other values (P Conclusion Saline perfusion at around 2 mm from the electrode surface while using an ICE in RFA improves deposition of energy and enlarges coagulation volume.

Cruz Ignacio

2007-07-01

224

Scanning Electron Microscopy of the Endometrium of Mares Infused with Gentamicin  

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Scanning electron microscopy (SEM) was used to study the endometrium of nine 1-year-old thoroughbred mares after twice intrauterine infusions of gentamicin, on 2 consecutive days. Five mares were infused on 2 consecutive days with 40 ml gentamicin (50 mg/ml) mixed with 80 ml of normal saline. Four mares served as controls and were infused with 120 ml of saline on 2 consecutive days. Endometrial biopsies were obtained from all mares 3 days after the second intrauterine infusion. Each biopsy was processed for SEM by standard methods. The endometrial epithelium of the gentamicin-infused mares had more cellular perforations than the saline-infused mares. The gentamicin-infused mares had less and shorter microvilli. The ciliated cells were fewer and some ciliated cells had disrupted and some had drooping cilia. The endometrial epithelium of the gentamicin-infused mares had a considerable number of endometrial cells that lost their luminal surfaces and some that lost their microvilli, compared to the saline-infused mares. We suggest that the information gathered in this pilot study should be used as basis for further investigation, on a larger scale basis, of the effects of repeated intrauterine infusion of gentamicin on the endometrial mucosa of mares.

Al-Bagdadi, F. K.; Eilts, B. E.; Richardson, G. F.

2004-04-01

225

Clinical assessment of first pass radionuclide ventriculography after dipyridamole infusion in patients with coronary artery disease  

International Nuclear Information System (INIS)

First pass radionuclide ventriculography (RNV) was performed after dipyridamole (D) infusion in 33 patients with coronary artery disease (CAD) and 15 normal volunteers. RNV findings after D infusion were compared with those of conventional exercise RNV and body surface ECG mapping (MAP). For patients with multiple vessel disease, left ventricular ejection fraction (LVEF) was significantly lower after D infusion than at rest. Wall motion abnormality (WMA) sites induced by D infusion were well coincident with those induced by exercise. Pressure rate product at exercise was significantly higher than that after D infusion, suggesting the different mechanism of the occurrence of WMA after D infusion and at exercise. The incidence of ischemic reaction tended to be higher after D infusion than at exercise in 25 patients with CAD. There was negative correlation between ST depression on MAP after D infusion and LVEF on RNV after D infusion. This RNV after D infusion can be used as a supplement tool to conventional exercise RNV in the evaluation of the degree of coronary artery lesions and preserved left ventricular function. (Namekawa, K.)

1986-01-01

226

Comparison of continuous subcutaneous and intravenous hydromorphone infusions for management of cancer pain.  

Science.gov (United States)

To compare the safety and efficacy of subcutaneous and intravenous infusion of opioid analgesics, a randomised, double-blind, crossover trial was carried out in inpatients. 15 patients with severe cancer pain received two 48 h infusions of hydromorphone--one subcutaneously and one intravenously in randomly allocated order. The study was made double-blind by the use of two infusion pumps throughout; during the active subcutaneous infusion the intravenous pump delivered saline and vice versa. Serial measurements of pain intensity, pain relief, mood, and sedation by means of visual analogue scales showed no clinically or statistically significant difference between the two infusion routes. Side-effects were slight, and the mean number of morphine injections for breakthrough pain did not differ significantly between the routes (4.8 [SD 4.5] for intravenous vs 5.3 [5.6] for subcutaneous). Plasma hydromorphone concentrations measured at 24 h and 48 h of infusion showed stable steady-state pharmacokinetics; the mean bioavailability from subcutaneous infusion was 78% of that with intravenous infusion. Because of the simplicity, technical advantages, and cost-effectiveness of continuous subcutaneous opioid infusion into the chest wall or trunk, intravenous opioid infusion for the management of severe cancer pain should be abandoned. PMID:1704089

Moulin, D E; Kreeft, J H; Murray-Parsons, N; Bouquillon, A I

1991-02-23

227

Corneal Endothelial Cell Density and Morphology Following Bolus versus Infusion Intracameral Adrenaline during Phacoemulsification  

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Full Text Available

PURPOSE: To compare early postoperative corneal endothelial cell density and morphology after phacoemulsification using bolus versus infusion intracameral adrenaline. METHODS: In this randomized clinical trial, 71 eyes of 71 patients scheduled for phaco-emulsification were randomly assigned to two groups: one group (31 eyes received bolus intracameral adrenaline (1:10,000 and the other group (30 eyes received adrenaline infusion (1:1,000,000. Pre- and one month postoperatively, a complete ophthalmologic examination as well as endothelial evaluation using ConfoScan III was performed; effective phaco time (EPT and mydriasis during surgery were also compared between the study groups. RESULTS: The two study groups were not significantly different in terms of demographic characteristics, lens opacity and EPT. Endothelial cell density was 2737±321 cell/mm2 in the bolus group vs 2742±426 cell/mm2 in the infusion group preoperatively (P=0.1. One month postoperatively, the rate of cell loss was 7.21% in the infusion group versus 8.87% in the bolus group (P= 0.13. Pupil diameter was > 6 mm in 48% of eyes in the infusion group vs 33% of eyes in the bolus group (P=0.5. CONCLUSION: Adrenaline was safe at the studied concentrations and there was no significant difference between bolus and infusion routes of administration in terms of pupil dilation and endothelial cell loss.

 
 
241

Augmentation of Chemotherapeutic Infusion Effect by TSU-68, an Oral Targeted Antiangiogenic Agent, in a Rabbit VX2 Liver Tumor Model  

International Nuclear Information System (INIS)

Purpose: This study was designed to investigate the in vivo effects of combination therapy with TSU-68 and chemotherapeutic infusion in a rabbit VX2 liver tumor model. Methods: This study was approved by the animal care committee at our institute. Three weeks before chemotherapeutic infusion, VX2 carcinoma was implanted into the livers of 32 rabbits. One week after chemotherapeutic infusion, vehicle was administered orally for 3 weeks in the control group (n = 16), and TSU-68 was administered orally at a daily dose of 200 mg/kg for 3 weeks in the treated group (n = 16). Computed tomography (CT) was performed before and 1, 2, 3, and 4 weeks after chemotherapeutic infusion. Tumor response was assessed according to the Response Evaluation Criteria in Solid Tumors (RECIST) on CT scan. The maximum thickness of viable tumor was measured on microscopic sections. Results: According to the RECIST, stable disease was observed in 9 (56%) rabbits and progressive disease in 7 (44%) in the control group, whereas partial response was observed in 1 (6%) rabbit and stable disease in 15 (94%) in the treated group. On pathologic examination, a viable lesion was present in 12 (75%) rabbits in the control group and in 6 (38%) rabbits in the treated group (P = 0.073). The mean maximum thickness of viable tumor in the treated group was significantly smaller than that in the control group (0.74 mm vs. 3.39 mm; P = 0.02). Conclusions: Oral administration of TSU-68 augmented the effect of chemotherapeutic infusion in a rabbit VX2 liver tumor model.

2012-02-01

242

Analysis of the Environmental Impact of Insulin Infusion Sets Based on Loss of Resources with Waste  

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Insulin pump therapy [continuous subcutaneous insulin infusion (CSII)] requires regular change of infusion sets every 2-3 days in order to minimize the risk of skin irritations or other adverse events. This has been discussed to be a potential burden to the environment. The purpose of this analysis was to perform an environmental assessment of insulin pump infusion sets based on loss of resources occurring during incineration of the discarded products and by means of a lifecycle concept used ...

Pfu?tzner, Andreas; Musholt, Petra B.; Malmgren-hansen, Bjoern; Nilsson, Nils H.; Forst, Thomas

2011-01-01

243

Hepatic artery infusion (HAI) for hepatic metastases in combination with hepatic resection and hepatic radiation  

International Nuclear Information System (INIS)

Renewed interest in hepatic artery infusion has been stimulated by the development of a totally implantable pump which eliminates many of the problems encountered by the external pumps and catheters. As the potential benefit of hepatic artery infusion would be greater if either all gross disease were removed by prior resection, or alternatively, if non-resectable disease were irradiated in conjunction with hepatic artery infusion, the authors initiated a phase I-II trial to evaluate combined modality therapy

1986-01-01

244

Protocol-directed insulin infusion sliding scales improve perioperative hyperglycaemia in critical care  

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Abstract Perioperative hyperglycaemia is associated with poor outcomes in patients undergoing cardiac surgery. Frequent postoperative hyperglycaemia in cardiac surgery patients has led to the initiation of an insulin infusion sliding scale for quality improvement. A systematic review was conducted to determine whether a protocol-directed insulin infusion sliding scale is as safe and effective as a conventional practitioner-directed insulin infusion sliding scale, within targe...

Hui Man; Kumar Arun; Adams Gary G

2012-01-01

245

Relief of pain by infusion of morphine after operation: does tolerance develop?  

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To see whether continuous intravenous infusion of opiates provides more effective postoperative relief of pain than conventional intramuscular injection these regimens were compared in a prospective double blind trial. Thirty patients undergoing elective cholecystectomy were allocated randomly to receive an infusion of morphine or an infusion of placebo (control group) for 24 hours. Both groups were allowed supplementary morphine boluses as requested. During the first 48 hours after operation...

Marshall, H.; Porteous, C.; Mcmillan, I.; Macpherson, S. G.; Nimmo, W. S.

1985-01-01

246

Propofol infusion syndrome in a super morbidly obese patient (BMI = 75)  

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Propofol infusion syndrome (PRIS) is a rare but often fatal complication as a result of large doses of propofol infusion (4–5 mg/kg/hr) for a prolonged period (>48 h). It has been reported in both children and adults. Besides large doses of propofol infusion, the risk factors include young age, acute neurological injury, low carbohydrate and high fat intake, exogenous administration of corticosteroid and catecholamine, critical illness, and inborn errors of mitochondrial fatty acid oxidatio...

Ramaiah, Ramesh; Lollo, Loreto; Brannan, Douglas; Bhananker, Sanjay M.

2011-01-01

247

A Multicenter Retrospective Experience of Infliximab in Crohn's Disease Patients: Infusion Reaction Rates and Treatment Persistency  

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Background: Infusion reactions have been associated with infliximab therapy, but no study has assessed how physicians treat and manage this common adverse event. Goals: To determine how gastroenterologists manage infusion reactions, identify prophylactic pretreatment protocols, and determine infliximab treatment persistence in the presence of infusion reactions. Method: This retrospective multicenter chart review analyzed data from adults younger than 90 years at the time of their first infli...

Keshavarzian, Ali; Mayer, Lloyd; Salzberg, Bruce; Garone, Michael; Finkelstein, Warren; Cappa, Joseph; Brand, Myron; Hain, Jon; Zelinger, David; Hegedus, Ronald; Diamond, Robert H.; Campbell, Ulka; Lane, Christi; Stang, Paul; Watson, John

2007-01-01

248

Rapid switch from oral antiparkinsonian combination drug therapy to duodenal levodopa infusion.  

Science.gov (United States)

Six patients with Parkinson's disease (PD) with severe motor complications were directly switched from their oral antiparkinsonian combination drug regime to nasoduodenal levodopa infusion without previously recommended transient treatment with levodopa alone. Duodenal levodopa infusion reduced motor complications to a considerable extent. We have shown that a prior change to an oral levodopa monotherapy and a slow titration of duodenal levodopa infusion may be skipped and a direct switch to duodenal levodopa is a safe option. PMID:17987653

Meiler, Birgit; Andrich, Jürgen; Müller, Thomas

2008-01-01

249

An economic justification for autologous blood re-infusion in primary total knee replacement surgery.  

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INTRODUCTION: To justify economically the use of autologous blood re-infusion after total knee replacement surgery compared with vacuum drains. To determine if the patients using autologous re-infusion units have a reduced allogenic blood transfusion requirement and hospital stay. PATIENTS AND METHODS: Prospectively, 50 patients undergoing primary unilateral total knee replacements with autologous re-infusion units were studied. They were matched for age, sex, type of prosthesis and the month...

Rees, J. E.; Jeavons, R.; Dixon, J. H.

2005-01-01

250

Does prolonged ?-lactam infusions improve clinical outcomes compared to intermittent infusions? A meta-analysis and systematic review of randomized, controlled trials  

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Full Text Available Abstract Background The emergence of multi-drug resistant Gram-negatives (MDRGNs coupled with an alarming scarcity of new antibiotics has forced the optimization of the therapeutic potential of available antibiotics. To exploit the time above the minimum inhibitory concentration mechanism of ?-lactams, prolonging their infusion may improve outcomes. The primary objective of this meta-analysis was to determine if prolonged ?-lactam infusion resulted in decreased mortality and improved clinical cure compared to intermittent ?-lactam infusion. Methods Relevant studies were identified from searches of MEDLINE, EMBASE, and CENTRAL. Heterogeneity was assessed qualitatively, in addition to I2 and Chi-square statistics. Pooled relative risks (RR and 95% confidence intervals (CI were calculated using Mantel-Haenszel random-effects models. Results Fourteen randomized controlled trials (RCTs were included. Prolonged infusion ?-lactams were not associated with decreased mortality (n= 982; RR 0.92; 95% CI:0.61-1.37 or clinical cure (n = 1380; RR 1.00 95% CI:0.94-1.06 compared to intermittent infusions. Subgroup analysis for ?-lactam subclasses and equivalent total daily ?-lactam doses yielded similar results. Most studies had notable methodological flaws. Conclusions No clinical advantage was observed for prolonged infusion ?-lactams. The limited number of studies with MDRGNs precluded evaluation of prolonged infusion of ?-lactams for this subgroup. A large, multicenter RCT with critically ill patients infected with MDRGNs is needed.

Van Arendonk Kyle J

2011-06-01

251

Aluminum Contents in Dry Leaves and Infusions of Commercial Black and Green Tea Leaves: Effects of Sucrose and Ascorbic Acid Added to Infusions  

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Full Text Available Tea consumption has increased due to its beneficial effects. Results from a lab study on the effect of sucrose (5 g per cup, 150 mL and/or ascorbic acid (2 mL per cup, 150 mL on dissolved aluminum compounds during the infusion of two commercial types of dry tea leaves (black, green with boiling water (5, 15 min infusion time are presented. Factors influencing the presence of dissolved aluminum in the infusions of both tea leaves were infusion time and sugar contents, as well as the interaction between ascorbic acid and sucrose (p < 0.05. Aluminum contents found after 15 min of infusion were 0.7 mg L–1 for black tea infusions added with sugar, and 0.69 mg L–1 for green tea added with both sugar and ascorbic acid. Both concentrations are higher than the level accepted in Mexico for drinking water (there is no act concerning tea infusions, that is 0.2 mg L–1.

Diego Armando Bárcena-Padilla

2011-09-01

252

C-Section  

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Full Text Available C-Section Introduction A Cesarean section, or C-section, is the surgical delivery of a baby through ... the baby while recovering from surgery. After a C-Section The hospital stay after a C-section ...

253

3-Hydroxybutyrate co-infused with noradrenaline decreases resulting plasma levels of noradrenaline in Wistar rats.  

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Pentobarbital-anaesthetized male Wistar rats were infused with 6microgkg-1min-1 of noradrenaline. The infusion was supplemented with 8.5 mgkg-1min-1 of D-3-hydroxybutyrate (3-OHB) for 15 min in order to determine its effect on the adrenergic response of the rat. Plasma levels of noradrenaline rose to a plateau of approximately 50 nmoll-1 with infusion. In the group infused with noradrenaline alone, noradrenaline levels were maintained for 1h. Supplementation with 3-OHB induced a decrease in plasma noradrenaline level that was inversely correlated with 3-OHB level. Aortic and interscapular brown adipose tissue temperatures increased with noradrenaline infusion, but the rise was arrested by 3-OHB; replacing 3-OHB with glucose had no effect. Infusion of saline, glucose or 3-OHB in the absence of noradrenaline did not induce a rise in temperature in either tissue. Blood 3-OHB concentration increased to 1.2 mmoll-1 during 3-OHB infusion, decreasing rapidly at the end of infusion. Blood glucose levels increased with noradrenaline infusion; the presence of high 3-OHB levels decreased glucose concentration. The effects observed were transient and dependent on 3-OHB concentration; these effects may help explain most of the other effects of noradrenaline described here. The role of 3-OHB as a regulator of adrenergic responses seems to be part of a complex fail-safe mechanism which prevents wasting. PMID:9359370

Cañas, N; Sanchis, D; Gómez, G; Casanovas, J M; Artigas, F; Fernández-López, J A; Remesar, X; Alemany, X

1997-10-01

254

An experimental study on renal arterial and parenchymal change caused by selective renal infusion of epinephrine  

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Selective infusion of the epinephrine into the renal artery has been used in the field of the diagnostic and the therapeutic radiology for correct diagnosis and effective treatment, respectively. However, administration of overdose of epinephrine may cause serious complication, renal infarction. The study was undertaken to evaluate the sequential change of renal arterial constrictive effect of selective infusion of epinephrine into renal artery and to determine the critical doses of epinephrine producing irreversible renal infarct. A total of 25 rabbits are used, which are divided into 5 groups. Under the general anesthesia is made the selective infusion of various doses of epinephrine into the right renal artery of the rabbits. At the various time interval during and after the epinephrine infusion, renal angiography was done, and 24 hrs. later, gross and microscopic findings of the kidney were observed. The results are as follows; 1. Vasoconstriction of renal artery occurred within 2 mins. infusion, and maximum effect within 5 mins. 2. It seems that there is correlation between the amount of infused epinephrine and the time taken to recover from constriction of renal artery. 3. When epinephrine is infused into the renal artery in the rate of 1 ug/min., renal infarct is not noticed below the level of 10 mins., but correlation between the amount of infused epinephrine and the frequency of renal infarct occurs above 20 mins. infusion.

Jeon, Seok Chol; Yeon, Kyung Mo; Han, Man Chung [College of Medicine, Seoul National University, Seoul (Korea, Republic of)

1981-06-15

255

Radiographic and Histologic Study After Infusion of Contrast Media into Rabbit Submandibular Gland  

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50 submandibular glands of rabbits were examined historadiologically after infusion with normal and over volumes of physiologic saline and 5 radiographic contrast media. The results were as follows: 1. All water soluble contrast media showed similar radiographic contrasts and absorbed about 5 minutes after infusion except Telebrix 30 which took 30 minutes in both normal and overfilled glands. 2. Lipid soluble medium, Lipiodol UF had excellent radiographic contrast and could be seen on the radiograms even after 24 hours after infusion. 3. Salivary glands infused with physiologic saline didn't show any histologic changes except slight duct dilation right after infusion. 4. Telebrix 30 caused mild to moderate duct dilation and inflammation at immediate and 24 hours after infusion which was more severe in overfilled glands. At 7 days after infusion, there were mild to moderate fibrosis of the gland and areas of necrosis was seen in overfilled glands. 5. Hypaque 60% showed similar histologic reactions to Telebrix 30 except more severe tissue destruction at 7 days after infusion. 6. Urografin 60% showed mildest histologic changes among the media used in the study. 7. Biliscopin had mild duct dilation which returned to normal after 7 days but there were moderate inflammation and tissue necrosis at that time. 8. Lipiodol UF showed severe duct dilation with numerous vacuoles and there were tissue fibrosis at 7 days after infusion but no tissue necrosis was seen.

Nah, Kyung Soo; Park, Tae Won [Department of Oral Radiology, Seoul National University, Seoul (Korea, Republic of)

1990-02-15

256

Quantitative evaluation of valvular regurgitation by "1"3"3Xenon infusion  

International Nuclear Information System (INIS)

Mitral and aortic regurgitation was evaluated by X-ray, dye dilution bolus, and "1"3"3Xenon infusion methods in 24 patients with mitral, aortic or both valve lesions. Good reproducibility was found using the "1"3"3Xenon infusion method. The regurgitant fraction estimated by "1"3"3Xenon constant infusion method correlates well with the results of the dye dilution method in mitral regurgitation as well as in aortic regurgitation. The "1"3"3Xenon infusion method is well-suited for quantitative evaluation of mitral and aortic regurgitation. For its simplicity, it is therefore recommended for further clinical evaluation in pharmacodynamic and preoperative studies. (author)

1983-01-01

257

An experimental study on renal arterial and parenchymal change caused by selective renal infusion of epinephrine  

International Nuclear Information System (INIS)

Selective infusion of the epinephrine into the renal artery has been used in the field of the diagnostic and the therapeutic radiology for correct diagnosis and effective treatment, respectively. However, administration of overdose of epinephrine may cause serious complication, renal infarction. The study was undertaken to evaluate the sequential change of renal arterial constrictive effect of selective infusion of epinephrine into renal artery and to determine the critical doses of epinephrine producing irreversible renal infarct. A total of 25 rabbits are used, which are divided into 5 groups. Under the general anesthesia is made the selective infusion of various doses of epinephrine into the right renal artery of the rabbits. At the various time interval during and after the epinephrine infusion, renal angiography was done, and 24 hrs. later, gross and microscopic findings of the kidney were observed. The results are as follows; 1. Vasoconstriction of renal artery occurred within 2 mins. infusion, and maximum effect within 5 mins. 2. It seems that there is correlation between the amount of infused epinephrine and the time taken to recover from constriction of renal artery. 3. When epinephrine is infused into the renal artery in the rate of 1 ug/min., renal infarct is not noticed below the level of 10 mins., but correlation between the amount of infused epinephrine and the frequency of renal infarct occurs above 20 mins. infusion

1981-06-01

258

Plasma Calcium, Inorganic Phosphate and Magnesium During Hypocalcaemia Induced by a Standardized EDTA Infusion in Cows  

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Full Text Available The intravenous Na2EDTA infusion technique allows effective specific chelation of circulating Ca2+ leading to a progressive hypocalcaemia. Methods previously used were not described in detail and results obtained by monitoring total and free ionic calcium were not comparable due to differences in sampling and analysis. This paper describes a standardized EDTA infusion technique that allowed comparison of the response of calcium, phosphorus and magnesium between 2 groups of experimental cows. The concentration of the Na2EDTA solution was 0.134 mol/l and the flow rate was standardized at 1.2 ml/kg per hour. Involuntary recumbency occurred when ionised calcium dropped to 0.39 – 0.52 mmol/l due to chelation. An initial fast drop of ionized calcium was observed during the first 20 min of infusion followed by a fluctuation leading to a further drop until recumbency. Pre-infusion [Ca2+] between tests does not correlate with the amount of EDTA required to induce involuntary recumbence. Total calcium concentration measured by atomic absorption remained almost constant during the first 100 min of infusion but declined gradually when the infusion was prolonged. The concentration of inorganic phosphate declined gradually in a fluctuating manner until recumbency. Magnesium concentration remained constant during infusion. Such electrolyte responses during infusion were comparable to those in spontaneous milk fever. The standardized infusion technique might be useful in future experimental studies.

Enemark JMD

2001-06-01

259

[Intra-arterial infusion of high dose methotrexate therapy in recurrent gliomas].  

Science.gov (United States)

Intra-arterial high dose methotrexate (MTX) infusion therapy for ACNU resistant recurrent gliomas was reported. MTX was administered 16 times to 6 patients. In all cases, 20% mannitol was infused to produce a reversible osmotic blood brain barrier disruption. Dosage of infused MTX was 1,000-2,000 mg per an artery. One case revealed a complete response on CT. Another case showed an intratumoral necrosis. Intra-arterial high dose MTX infusion yielded high arterial and cerebrospinal fluid concentration of MTX. No critical complications were experienced. Dosage of MTX, an interval between the therapies and proper timing to start leucovorin rescue will be discussed. PMID:2117886

Hayashi, A; Kyuma, Y

1990-08-01

260

Stabilization of a percutaneously implanted port catheter system for hepatic artery chemotherapy infusion  

International Nuclear Information System (INIS)

A port catheter system for hepatic artery infusion chemotherapy was implanted percutaneously via the left subclavian artery in 41 patients for treatment of unresectable liver metastases. The catheter tip was inserted into the gastroduodenal artery (GDA), the end hole was occluded with a guidewire fragment, and a side-hole for infusion was positioned at the bifurcation of the proper hepatic artery and the GDA. The GDA was embolized with steel coils around the infusion catheter tip via a transfemoral catheter. This procedure is designed to reduce the incidence of hepatic artery occlusion and infusion catheter dislocation.

1999-07-01

 
 
 
 
261

Stabilization of a Percutaneously Implanted Port Catheter System for Hepatic Artery Chemotherapy Infusion  

International Nuclear Information System (INIS)

A port catheter system for hepatic artery infusion chemotherapy was implanted percutaneously via the left subclavian artery in 41 patients for treatment of unresectable liver metastases. The catheter tip was inserted into the gastroduodenal artery (GDA), the end hole was occluded with a guidewire fragment, and a side-hole for infusion was positioned at the bifurcation of the proper hepatic artery and the GDA. The GDA was embolized with steel coils around the infusion catheter tip via a transfemoral catheter. This procedure is designed to reduce the incidence of hepatic artery occlusion and infusion catheter dislocation

1999-07-01

262

Epidural infusion of levobupivacaine and sufentanil following thoracotomy.  

Science.gov (United States)

A prospective, randomised, double-blind study was conducted to compare the efficacy of two doses of levobupivacaine combined with sufentanil for continuous epidural infusion following thoractomy. A total of 72 patients undergoing lobectomy or pneumonectomy were enrolled. An epidural catheter was inserted between the levels of T4 and T6 before induction of anaesthesia and a loading dose of levobupivacaine and sufentanil was administered. At the end of surgery an epidural infusion was commenced at 5 mlxh(-1) and continued for 48 h. Patients were randomly allocated to receive either levobupivacaine 0.125% (group A) or 0.0625% (group B) and all patients also received sufentanil (1 microgxml(-1)). Visual analogue pain scores after coughing (VASi) were always higher in group B (p < 0.05); VAS pain scores at rest were higher for the first 4 h and at 16 and 28 h in group B (p < 0.05). Total morphine consumption and requests number was lower in group A (p < 0.05). Better pain relief was achieved using epidural 0.125% levobupivacaine. PMID:17845650

De Cosmo, G; Congedo, E; Mascia, A; Adducci, E; Lai, C; Aceto, P

2007-10-01

263

Boron biodistribution after boronophenylalanine-fructose (BPA-F) infusion  

International Nuclear Information System (INIS)

In vivo dynamic tissue boron concentration measurements are not available for BNCT in clinical settings. Whole blood boron concentrations and converting factors are currently used in stead to estimate the boron concentrations in the target tissues and the ensuing radiation doses. We studied with ICP-AES the boron concentrations in blood after 2 hour intravenous infusions of BPA-F in 8 patients (290 mg/kg). As BPA-F is water soluble we calculated respective doses per lean body weight (LBW (360 - 471 mg/kg) - the peak plasma concentrations and area under plasma boron concentration time curve correlated with the mg/LBW dose, but not with dose per skin surface area (mg/m"2). The mean boron concentrations in plasma, whole blood and red cells at the infusion were 32.1 ± 3.3, 23.3 ± 2.4 and 9.5 ± 2.8, respectively. LBW doses should be considered to ensure more homogenous dosing and BNCT irradiation. (author)

2000-10-01

264

Boron biodistribution after boronophenylalanine-fructose (BPA-F) infusion  

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In vivo dynamic tissue boron concentration measurements are not available for BNCT in clinical settings. Whole blood boron concentrations and converting factors are currently used in stead to estimate the boron concentrations in the target tissues and the ensuing radiation doses. We studied with ICP-AES the boron concentrations in blood after 2 hour intravenous infusions of BPA-F in 8 patients (290 mg/kg). As BPA-F is water soluble we calculated respective doses per lean body weight (LBW) (360 - 471 mg/kg) - the peak plasma concentrations and area under plasma boron concentration time curve correlated with the mg/LBW dose, but not with dose per skin surface area (mg/m{sup 2}). The mean boron concentrations in plasma, whole blood and red cells at the infusion were 32.1 {+-} 3.3, 23.3 {+-} 2.4 and 9.5 {+-} 2.8, respectively. LBW doses should be considered to ensure more homogenous dosing and BNCT irradiation. (author)

Kallio, M.; Kulvik, M.; Laakso, J.; Ruokonen, I.; Vaehaetalo, J.; Faerkkilae, M. [University of Helsinki (Finland); Rasilainen, M.; Jaerviluoma, E. [Helsinki University Central Hospital, Pharmacy, Helsinki (Finland)

2000-10-01

265

Tea and herbal infusions: Their antioxidant activity and phenolic profile  

International Nuclear Information System (INIS)

Tea and herbal infusions have been studied for their polyphenolic content, antioxidant activity and phenolic profile. The total phenolics recovered by ethyl acetate from the water extract, were determined by the Folin-Ciocalteu procedure and ranged from 88.1 ± 0.42 (Greek mountain tea) to 1216 ± 32.0 mg (Chinese green tea) GAE (Gallic acid equivalents)/cup. The antioxidant activity was evaluated by two methods, DPPH and chemiluminescence assays, using Trolox and quercetin as standards. The EC50 of herbal extracts ranged from 0.151 ± 0.002 mg extract/mg DPPH (0.38 quercetin equivalents and 0.57 Trolox equivalents), for Chinese green tea, to 0.77 ± 0.012 mg extract/mg DPPH (0.08 quercetin equivalents and 0.13 Trolox equivalents), for Greek mountain tea. Chemiluminescence assay results showed that the IC50 ranged from 0.17 ± 3.4 x 103 lg extract/ml of the final solution in the measuring cell (1.89 quercetin and 5.89 Trolox equivalents) for Chinese green tea, to 1.10 ± 1.86 x 102 g extract/ml of the final solution in the measuring cell (0.29 quercetin and 0.90 Trolox equivalents) for Greek mountain tea. The phenolic profile in the herbal infusions was investigated by LC-DAD-MS in the positive electrospray ionization (ESI) mode. About 60 different flavo- noids, phenolic acids and their derivatives have been identified. (author)

2005-01-01

266

Interventional DSA for lung cancer. Bronchial artery infusion  

Energy Technology Data Exchange (ETDEWEB)

Bronchial artery infusion (BAI) has been looked to as an important adjunct for controlling lung cancer. However, there are some anatomic facts to meet in performing angiography: multiplicity of the bronchial artery with wide variation of ramification pattern. To deal with these problems, since 1984, we have been working with DSA apparatus (Siemens: ANGIOTRON) for intervention in 162 cases of lung cancer. Because of higher contrast resolution, subtracted dynamic image and realtime replay on CRT, DSA allows (1) bronchial artery mapping on aortography, (2) prompt verification of the areas to be or not to be infused by anticancer drugs, and (3) tumor stain not only in the primary lesion but also metastasized lymph nodes or mediastinal invasion. DSA aortography evaluated the right-sided bronchial artery more frequently (90.1%) than the left-sided (46.3%). Tumor location made feeding vessels mare remarkable on DSA: 96.0% in the right and 68.9% in the left . The overall accuracy of BAI basically depends on the result of DSA measuring 91.9% (149 of 162 cases). The effect of BAI combined with radiation therapy, for each histologic category, is preliminarily estimated in two groups: one with two drugs and another with CDDP. Small cell carcinoma with 'two drugs' and squamous cell carcinoma with CDDP seem to show statistical predominance in the period of 50% tumor size reduction. (author).

Kuroda, Yasumasa; Takahashi, Masashi; Sano, Akira; Imanaka, Kazufumi; Kono, Michio.

1989-04-01

267

[Significance of isuprel infusion in unexplained syncope after myocardial infarction].  

Science.gov (United States)

The prognosis for patients with complications and syncope following myocardial infarction depends on the left ventricular ejection fraction (LVEF) and the mechanism of the syncope. The aim of this study was to evaluate the results of an electrophysiological study (EPS) following isoproterenol infusion in patients with a negative EPS under basal conditions. The population included 60 patients, aged 60 +/- 12 years, 5 of whom had syncope on effort or with stress. The EPS included measurement of AV conduction, with programmed atrial and ventricular stimulation. It was repeated following infusion of 2 to 4 microg/kg of isoproterenol. Results: An arrhythmia was identified as preceding the syncope in 27 patients (45%): ventricular tachycardia (VT) n = 16, supraventricular tachycardia (n = 5), 2nd or 3rd degree AV block (n = 3), vaso-vagal reaction (n = 3): 3 subjects developed coronary ischaemia. The subjects with VT on Isuprel differed from those without VT, with a lower LVEF (34 +/- 8 vs 45 +/- 14%) (p < 0.05), a higher incidence of effort related syncope (4 vs 1) and a higher risk of cardiac death (6/16 vs 2/44) (p < 0.01). In conclusion, we recommend repeating the electrophysiogical test under Isuprel in patients with complications after MI and a negative EPS in the basal state whether or not they have exercise related syncope, which will reveal an arrhythmia in 45% of cases. Subjects with inducible VT are at high risk of cardiac death. PMID:16555696

Brembilla-Perrot, B; Muhanna, I; Terrier de la Chaise, A; Louis, P; Nippert, M; Claudon, O; Belhakem, H; Selton, O; Ernst, Y

2006-02-01

268

Abnormal thallium 201 scintigraphy during low-dose vasopressin infusions  

International Nuclear Information System (INIS)

Thallium 201 ("2"0"1Tl) myocardial scans were obtained in 16 patients just prior to the discontinuation of a vasopressin infusion (.1 to .2 units/min) administered for the treatment of upper gastrointestinal bleeding. Repeat scintigraphy was performed two to three hours after the vasopressin was stopped. Eleven of the 16 patients (69 percent) demonstrated areas of decreased myocardial "2"0"1Tl uptake that resolved after the infusion was stopped. Heart rate-blood pressure product was significantly lower at the time of the second scan. Autopsies were secured in three of 11 scan-positive patients: one had severe coronary artery obstruction, one nonsignificant disease, and another had normal coronary arteries. Vasopressin, even at low doses, can induce abnormalities in myocardial perfusion that are probably mediated by a direct effect on the coronary circulation. They are usually not detectable by routine monitoring techniques and conceivably form the basis for the cardiovascular morbidity associated with the use of this agent

1986-01-01

269

THE ROLE OF INTRAVENOUS AMINO ACID INFUSION IN OLIGOHYDRAMNIOS  

Directory of Open Access Journals (Sweden)

Full Text Available Oligohydramnios means the fetus is in a compromised condition. Ante partum amniotic fluid index (A.F.I. assessment is one of the reliable, good predictor and standard technique for assessment of fetal well-being in antenatal period. In the present study 25 cases of Oligohydramnios in the third trimester were given intravenous amino acid in 1000cc of 10% fructodex drip on 1st day and the amino acid infusion drip in 500 ml of 10% fructodex daily till 6 days. After that biweekly till patient deliver or till term. There were 4 cases of severe Oligohydramnios and 21 cases of moderate Oligohydramnios at the time of their first visit. After amino acid infusion therapy, on repeat ultrasonography, 9 (36% cases patients with moderate Oligohydramnios had improved amniotic fluid index (AFI to normal whereas two patients with severe Oligohydramnios had improved A.F.I. to moderate Oligohydramnios and remaining 12 and two patients of moderate and severe Oligohydramnios group patients did not show any changes in A.F.I. Maximum cases delivered vaginally.

Ritu Gupta et al

2012-10-01

270

Chronic spinal infusion of loperamide alleviates postsurgical pain in rats.  

Science.gov (United States)

Plantar incision in rat generates spontaneous pain behaviour. The opioid drug, morphine used to treat postsurgical pain produces tolerance after long-term administration. Loperamide, a potent mu-opioid agonist, has documented analgesic action in various pain conditions. However, loperamide analgesia and associated tolerance following continuous spinal administration in postsurgical pain has not been reported. Chronic spinal infusion of drugs was achieved using intrathecal catheters connected to osmotic minipump. Coinciding with the onset of spinal infusion of loperamide or morphine, rats were subjected to plantar incision. Pain-related behaviour was assessed by Hargreaves apparatus (thermal hyperalgesia) and von Frey filaments (mechanical allodynia). Morphine and loperamide (0.5, 1 and 2 microL/h) induced analgesia was observed until 7th day post-plantar incision in Sprague-Dawley rats. Morphine and loperamide produced dose-dependent analgesia. Loperamide, in the highest dose, produced analgesia till 7th day. However, the highest dose of morphine produced inhibition of thermal hyperalgesia till 5th day and mechanical allodynia only till 3rd day post-plantar incision. Morphine and loperamide produced analgesia in postsurgical pain, which may be mediated through different mechanisms. Longer duration of analgesia with loperamide could probably be due sustained blockade of calcium channels. PMID:24772934

Kumar, Rakesh; Reeta, K H; Ray, Subrata Basu

2014-04-01

271

Cesarean Section Birth  

Medline Plus

Full Text Available ... cesarean section with her last delivery. Other common reasons for cesarean sections are when we can tell ... fit through the birth canal, that's another common reason for cesarean section. Other less common reasons are ...

272

The Efficacy of Postoperative Wound Infusion with Bupivacaine for Pain Control after Cesarean Delivery: Randomized Double Blind Clinical Trial  

Directory of Open Access Journals (Sweden)

Full Text Available Objective: This study investigated the efficacy of bupivacaine wound infusion for pain control and opioid sparing effect after cesarean delivery."nMaterials and methods: We conducted a randomized double blind, placebo controlled clinical trial on 60 parturients undergoing cesarean section at a university hospital in Tehran. Patients were randomized to receive a pump infusion system that was filled with either 0.25% bupivacaine or equal volume of distilled water. A catheter was placed above the fascia and connected to electronic pump for 24 hours. Postoperative analog pain scores and morphine consumption were assessed at 6, 12 and 24 hours. Also time interval to first ambulation, length of hospitalization, complications and patient satisfaction were recorded. Data were analyzed using the SPSS software and P < 0.05 was considered statistically significant. Mann-Whitney u-test, student t-test and chi-square were used. "nResults: There were no differences in patient demographics and length of hospitalization and patient-generated resting pain scores between the two groups. Pain scores after coughing and leg raise during the first 6 postoperative hours were significantly less in the Bupivacaine group (P<0.001. The total dose of morphine consumption during the 24 hours study period was 2.5 ± 2.5 mg vs. 7.3 ± 2.7 mg for the bupivacaine and control groups, respectively (P<0.001. Compared with the control group, time to first ambulation was shorter in the bupivacaine group (11± 5h vs. 16 ± 4h (P< 0.01. "nConclusion: Bupivacaine wound infusion was a simple and safe technique that provides effective analgesia and reduces morphine requirements after cesarean delivery.

Azin Alavi

2007-06-01

273

Brain SPECT by intraarterial infusion of 99mTc-HMPAO for assessing the cerebral distribution of carotid artery infusions in patient with brain tumor  

International Nuclear Information System (INIS)

In order to assess the cerebral distribution of intracarotid chemotherapy, 17 postoperative patients with brain tumor underwent brain SPECT obtrained by intraarterial infusion of 18.5 MBq of 99mTc-d,l,-hexamethylpropyleneamine oxime (99mTc-HMPAO). Injection methods were continuous (5.0 ml/min) or pulsatile infusion with supra- or infraophthalmic catheterization. The findings obtained by brain SPECT were frequently different from those of angiography and/or DSA. In supraophthalmic catheterization with continuous infusion, only 2 of 10 studies (20%) had homogeneous distribution and 5 of them (50%) had maldistribution of 99mTc-HMPAO which appears in association with laminar flow effect. The remaining 3 studies showed localized distribution (two: tumor localization, one: healthy brain localization). On the other hand, all of 5 studies with pulsatile infusion had homogeneous distribution of 99mTc-HMPAO. In infraophthalmic catheterization, all but one of 5 studies had homogeneous distribution with continuous infusion. These results suggest that pulsatile infusion may be effective in eliminating maldistribution of 99mTc-HMPAO in supraophthalmic catheterization. In conclusion, we are convinced that 99mTc-HMPAO is a useful intraarterial agent for assessing cerebral distribution of intracarotid chemotherpay. (author)

1993-06-01

274

Brain SPECT by intraarterial infusion of [sup 99m]Tc-HMPAO for assessing the cerebral distribution of carotid artery infusions in patient with brain tumor  

Energy Technology Data Exchange (ETDEWEB)

In order to assess the cerebral distribution of intracarotid chemotherapy, 17 postoperative patients with brain tumor underwent brain SPECT obtrained by intraarterial infusion of 18.5 MBq of [sup 99m]Tc-d,l,-hexamethylpropyleneamine oxime ([sup 99m]Tc-HMPAO). Injection methods were continuous (5.0 ml/min) or pulsatile infusion with supra- or infraophthalmic catheterization. The findings obtained by brain SPECT were frequently different from those of angiography and/or DSA. In supraophthalmic catheterization with continuous infusion, only 2 of 10 studies (20%) had homogeneous distribution and 5 of them (50%) had maldistribution of [sup 99m]Tc-HMPAO which appears in association with laminar flow effect. The remaining 3 studies showed localized distribution (two: tumor localization, one: healthy brain localization). On the other hand, all of 5 studies with pulsatile infusion had homogeneous distribution of [sup 99m]Tc-HMPAO. In infraophthalmic catheterization, all but one of 5 studies had homogeneous distribution with continuous infusion. These results suggest that pulsatile infusion may be effective in eliminating maldistribution of [sup 99m]Tc-HMPAO in supraophthalmic catheterization. In conclusion, we are convinced that [sup 99m]Tc-HMPAO is a useful intraarterial agent for assessing cerebral distribution of intracarotid chemotherpay. (author).

Kosuda, Shigeru; Kusano, Shoichi (National Defense Medical College, Saitama (Japan)); Aoki, Shigeki (and others)

1993-06-01

275

Ist die subkutane Infusion eine praktische Alternative in der Geriatrie?  

Directory of Open Access Journals (Sweden)

Full Text Available In der Geriatrie hat das Thema der Flüssigkeitssubstitution einen besonderen Stellenwert - so verwundert es nicht, daß hauptsächlich Geriater die subkutane Infusion als Methode der Flüssigkeitszufuhr für ihre Patienten wiederentdeckten. Sie gilt heute als einfach, komplikationsarm, sicher und vor allem als für den Patienten schonend. Sie hat viele Vorteile und nur wenige Nachteile. Ihre Domäne ist die Vorbeugung von Dehydratation in Situationen, die dafür ein Risiko darstellen, sowie die Therapie von leichter bis mäßiger Dehydratation. Die bis vor wenigen Jahren, als neue Publikationen zu diesem Thema erschienen, archaisch anmutende Methode wurde jahrzehntelang kaum mehr angewandt und wenn, dann höchstens mit einem schlechten Gewissen und der Verzweiflung, keinen intravenösen Zugang gefunden zu haben. Sie schnitt auch hinsichtlich Sicherheit und Komplikationsrate im Vergleich zu den damals neu entwickelten Technologien und Materialien für den intravenösen Zugang schlechter ab. In einer kurzen Literaturübersicht wird über die Indikationen, Kontraindikationen und die Technik dieser wiederentdeckten Methode der Flüssigkeitssubstitution berichtet.

Frühwald T

2001-01-01

276

Polymeric mandrels: supersmooth finish by an infusion process  

International Nuclear Information System (INIS)

Extremely smooth surfaces (less than 1 mm maximum defect size) have been produced on acrylic polymer rods by an infusion process. The technique involves bathing the rod in a mixture of a solvent and a diluent, a nonsolvent for the polymer. This causes the rod to soften and permits limited flow and leveling of its surface. The solvent is then gradually displaced from the bath by additional diluent. As this occurs, the surface of the rod becomes rigid once more, but now with a defect-free finish. Acetone may be used as the solvent. The smoothest surfaces have been obtained using a mixture of 50% water and 50% polyethylene glycol with a molecular weight of about 4000 as the diluent

1981-01-01

277

[Salvage of digits replantations by direct arterial antithrombotic infusion].  

Science.gov (United States)

At the end of the seventy, we saw the reconstructive microsurgery developed to such an extent that it became a new and an independent surgical specialty. The development of the microsurgical instrumentation and the description of the surgical anatomy allowed the application of this technology to the most complex plastic reconstructions and particularly to the replantation of the amputated digits, especially the very distal digital amputations. Nowadays, the indications of digital replantation are well-defined according to numerous parameters conditioning the anatomical result and the functional outcome. It is well-known that the replantation of the amputated digit should be realized as soon as possible with optimal conditions of digital hibernation during the patient transport. In spite of that technical progress, the failure rate is still relatively important. The causes are sometimes recognizable and connected to technical defection, such as a non permeable vascular anastomosis, bad hemodynamics conditions or an insufficient anticoagulation, while in certain cases, the digital ischemia occurs in spite of permeable and technically successful arterial anastomosis. We then consider a "no reflow phenomenon". It corresponds to the constitution of vascular microthrombi which will block the arteriolar network. Those microthrombi are inaccessible to the microsurgical techniques and their treatment remains medical by intra-arterial infusion of antithrombotic agents. Through our series of fifteen digital replantations, having suffered a "no reflow phenomenon", we are going to present the fibrinolytic protocol we used and the promising results we obtained. All our patients were victims of traumatisms associating avulsions and crush injuries mechanisms. The conditions of preservation of the amputated digits were all quite unfavourable: 1) the amputated digit soaked in water in 5 cases; 2) the amputated fingers underwent a long-term "warm ischemia" in three cases, going up to 13 hours for one of them; 3) the amputated digits were completely frozen in six cases; 4) and one amputated finger was correctly hibernated but for too long a period (8 hours). The signs of ischemia appeared very prematurely in the first minutes after the microvascular revascularisation in ten cases, and in average within three hours postoperatively in the other five cases, with extreme cases going from 2 up to 6 hours. As soon as the diagnosis of "no reflow phenomenon" was confirmed, an intra-arterial catheter was fixed. The radial axis was chosen as the arterial infusion way and approached at the level of the pulse groove. The antithrombotic protocol included a flash of 50,000 UI of urokinase, 36 ml of lidocaïne 1% and 40 mg of enoxaparine, followed by an electric syringe infusion the first six hours with 150,000 UI of urokinase, 36 ml of lidocaïne 1% and 40 mg of enoxaparine at 6 cc/h speed. The urokinase was then interrupted but the intra-arterial infusion maintained with 72 ml of lidocaïne 1% and 80 mg of enoxaparine for 24 hours, at a 3 cc/h speed, and this for ten days. In 12 cases, the "no reflow phenomenon" was able to be raised and the digital vascularization restored. The success rate is very encouraging (80%) and it turns this protocol into a precious ally of the digit replantation microsurgery and an effective therapeutic means way against the "no reflow phenomenon". PMID:16626848

Oufquir, A; Bakhach, J; Panconi, B; Guimberteau, J-C; Baudet, J

2006-12-01

278

Photodynamic therapy with Photofrin II by bronchial artery infusion  

Science.gov (United States)

Photodynamic therapy (PDT) utilizing Photofrin II is proving to be an effective modality in the treatment of early stage lung cancer. However, wider clinical application of Photofrin II as a photosensitizer for various cancers is hampered by the potentially serious and prolonged skin photosensitivity. To prevent these side effects and reduce the inpatient period, we recently tried to give reduced doses of Photofrin II by bronchial artery infusion (BAI). Six patients with endoscopically evaluated early stage carcinoma of the lung were given 0.7 mg/kg of Photofrin II by BAI 48 hours before PDT. Complete remission was obtained in all 6 cases, and there was no evidence of skin photosensitivity when exposed to outside light under careful surveillance at one week after PDT.

Okunaka, Tetsuya; Kato, Harubumi; Konaka, Chimori; Kinoshita, Komei; Yamada, Kimito

1993-03-01

279

Use of a Tea Infuser to Submerge Low-Density Dry Ice  

Science.gov (United States)

A simple tea infuser is obtained and been used as a container for the dry ice to simulate the effect from high-density dry ice. The tea infuser is a simple, low cost device to allow instructors with access to dry ice makers to effectively use the interesting demonstration.

Fictorie, Carl P.; Vitz, Ed

2004-01-01

280

Effects of radiolabelled monoclonal antibody infusion on blood leukocytes in cancer patients  

Energy Technology Data Exchange (ETDEWEB)

This study was undertaken to investigate the effects of a single infusion of radiolabelled murine monoclonal antibody (MAb) on peripheral blood leukocytes in cancer patients. Eleven patients with disseminated colon cancer, malignant melanoma, or lung adenocarcinoma were infused with 111In-labelled anti-ZCE 025, anti-p97 type 96.5c, or LA 20207 MAb, respectively. Blood samples were obtained before infusion, immediately after infusion (1 hr), and at 4 and 7 days postinfusion. Flow cytometry analysis of CD3+, CD4+, CD8+, CD16+, and CD19+ lymphocytes showed increasing CD4:CD8 ratios in seven patients after infusion. This phenomenon was not restricted to antibody subclass or to type of cancer. Two of the remaining patients exhibited a marked post-infusion increase in CD8+ cells. In all three patients with malignant melanoma, decreasing levels of CD16+ lymphocytes were noted after infusion and natural killer cell cytotoxicity showed fluctuations which paralleled the changes in the CD16+ subpopulation. Oxygen radical production by phagocytic cells was markedly affected in three subjects. These results suggest that a single infusion of radiolabelled murine MAb may alter the balance of critical lymphocyte subpopulations and modulate other leukocyte responses in cancer patients.

Gridley, D.S.; Slater, J.M.; Stickney, D.R. (Loma Linda Univ./Independent Order of Foresters Cancer Research Laboratory, CA (USA))

1990-01-01

 
 
 
 
281

Development of nitrogen infusion technology for fighting and inhibition of fires  

Energy Technology Data Exchange (ETDEWEB)

Nitrogen infusion was used to inhibit underground fires. It can be used to contain underground fires in cases where either the area is not properly sealed off or there is a leakage from the surface. The period required before reopening a mine/district can be considerably reduced by nitrogen infusion. Case histories using this technology are presented.

Garg, P.C.

1987-05-01

282

Thermoplastic film infusion process for long fiber reinforced composites using rubber expandable tools  

Energy Technology Data Exchange (ETDEWEB)

Thermoplastic film infusion process was investigated by using a rubber tool, which intrinsically contains a thermally-expandable characteristic and effectively compensates for the pressure loss caused by thermoplastic polymer infusion. Increasing temperature up to the melting temperature of matrix, the polymer melt subsequently infused into the dry fabric, but the pressure was successfully sustained by the rubber tool. Even with the decreased resin volume, the rubber tool produced sufficiently high elastic force for continuous resin infusion. Combining D'Arcy's law with the compressibility of rubber tool and elastic fiber bed, a film infusion model was developed to predict the resin infusion rate and pressure change as a function of time. In addition, the film infusion process without the rubber tool was viewed and analyzed by a compression process of the elastic fiber bed and viscous resin melt. The compressibility of fiber bed was experimentally measure and the multiple-step resin infusion was well described by the developed model equations. (author). 36 refs., 9 figs.

Kim, D.W. [Oriental Industry Co, Ltd. (Korea); An, Y.S.; Lee, Y.K. [Sungkyunkwan University, Suwon (Korea); Kim, S.W. [Kyunggi University, Suwon (Korea); Nam, S.D. [Sungkyunkwan University, Suwon (Korea)

2001-01-01

283

Toxicity of Guanazole (NSC 1895) Administered by 48-Hour Intravenous Infusions in Dogs.  

Science.gov (United States)

Two dogs were administered 5.0 gm/kg Guanazole, Triazole 3,5-diamino-S (NSC 1895) by 48-hour i.v. infusion followed by an observation period of 183 days and a second infusion of 7.5 gm/kg. Clinical signs were minimal but liver damage was indicated by tran...

P. E. Palm E. P. Arnold P. C. Rachwall C. J. Kensler

1972-01-01

284

Vancomycin penetration of uninfected pleural fluid exudate after continuous or intermittent infusion.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Blood and pleural exudate samples were obtained from 16 patients receiving intermittent or continuous infusions of vancomycin after lung surgery. The areas under the concentration-time curves for blood and pleural exudates were identical for both administration schedules, while continuous infusion allowed the concentrations in pleural exudates to be more sustained (mean concentration, 12 mg/liter).

Byl, Baudouin; Jacobs, Fre?de?rique; Wallemacq, Pierre; Rossi, Camelia; Francquen, Philippe; Cappello, Matteo; Leal, Teresinha; Thys, Jean-pierre

2003-01-01

285

Vancomycin penetration of uninfected pleural fluid exudate after continuous or intermittent infusion.  

Science.gov (United States)

Blood and pleural exudate samples were obtained from 16 patients receiving intermittent or continuous infusions of vancomycin after lung surgery. The areas under the concentration-time curves for blood and pleural exudates were identical for both administration schedules, while continuous infusion allowed the concentrations in pleural exudates to be more sustained (mean concentration, 12 mg/liter). PMID:12760889

Byl, Baudouin; Jacobs, Frédérique; Wallemacq, Pierre; Rossi, Camelia; de Francquen, Philippe; Cappello, Matteo; Leal, Teresinha; Thys, Jean-Pierre

2003-06-01

286

Vancomycin Penetration of Uninfected Pleural Fluid Exudate after Continuous or Intermittent Infusion  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Blood and pleural exudate samples were obtained from 16 patients receiving intermittent or continuous infusions of vancomycin after lung surgery. The areas under the concentration-time curves for blood and pleural exudates were identical for both administration schedules, while continuous infusion allowed the concentrations in pleural exudates to be more sustained (mean concentration, 12 mg/liter).

Byl, Baudouin; Jacobs, Fre?de?rique; Wallemacq, Pierre; Rossi, Camelia; Francquen, Philippe; Cappello, Matteo; Leal, Teresinha; Thys, Jean-pierre

2003-01-01

287

Effects of radiolabelled monoclonal antibody infusion on blood leukocytes in cancer patients  

International Nuclear Information System (INIS)

This study was undertaken to investigate the effects of a single infusion of radiolabelled murine monoclonal antibody (MAb) on peripheral blood leukocytes in cancer patients. Eleven patients with disseminated colon cancer, malignant melanoma, or lung adenocarcinoma were infused with 111In-labelled anti-ZCE 025, anti-p97 type 96.5c, or LA 20207 MAb, respectively. Blood samples were obtained before infusion, immediately after infusion (1 hr), and at 4 and 7 days postinfusion. Flow cytometry analysis of CD3+, CD4+, CD8+, CD16+, and CD19+ lymphocytes showed increasing CD4:CD8 ratios in seven patients after infusion. This phenomenon was not restricted to antibody subclass or to type of cancer. Two of the remaining patients exhibited a marked post-infusion increase in CD8+ cells. In all three patients with malignant melanoma, decreasing levels of CD16+ lymphocytes were noted after infusion and natural killer cell cytotoxicity showed fluctuations which paralleled the changes in the CD16+ subpopulation. Oxygen radical production by phagocytic cells was markedly affected in three subjects. These results suggest that a single infusion of radiolabelled murine MAb may alter the balance of critical lymphocyte subpopulations and modulate other leukocyte responses in cancer patients

1990-01-01

288

The influence of extended glucagon infusion on liver cell regeneration after partial hepatectomy in the rat.  

Science.gov (United States)

Extended infusion of various amounts of glucagon leads, in normal rats, to a slight reduction in liver cell DNA synthesis. After partial hepatectomy the extended infusion of glucagon causes a large reduction in DNA synthesis in the remaining liver. PMID:549425

Strecker, W; Goldberg, M; Feeny, D A; Ruhenstroth-Bauer, G

1979-12-01

289

Randomized Trial of a Calling-Infused Career Workshop Incorporating Counselor Self-Disclosure  

Science.gov (United States)

A randomized controlled trial was used to test (1) the efficacy of a two-session career development workshop for college student participants; (2) the effect of counselor self-disclosure on outcomes; and (3) the effect of infusing calling and vocation concepts on outcomes. Both standard (person-environment fit) and calling/vocation-infused…

Dik, Bryan J.; Steger, Michael F.

2008-01-01

290

A Study of Mathematics Infusion in Middle School Technology Education Classes  

Science.gov (United States)

The present study examined the impact of introducing a mathematics infused engineering/technology education (ETE) curriculum on students' mathematics content knowledge and attitudes toward mathematics. The purpose of the present study was to: (a) compare the effects of a mathematics infused ETE curriculum and a control curriculum on student…

Burghardt, M. David; Hecht, Deborah; Russo, Maria; Lauckhardt, James; Hacker, Michael

2010-01-01

291

Extended-Infusion Cefepime Reduces Mortality in Patients with Pseudomonas aeruginosa Infections  

Science.gov (United States)

In an era of escalating resistance and a lack of new antimicrobial discovery, stewardship programs must utilize knowledge of pharmacodynamics to achieve maximal exposure in the treatment of Pseudomonas aeruginosa infections. We evaluated the clinical and economic outcomes associated with extended-infusion cefepime in the treatment of P. aeruginosa infections. This single-center study compared inpatients who received cefepime for bacteremia and/or pneumonia admitted from 1 January 2008 through 30 June 2010 (a 30-min infusion of 2 g every 8 h) to those admitted from 1 July 2010 through 31 May 2011 (a 4-h infusion of 2 g every 8 h). The overall mortality was significantly lower in the group that received extended-infusion treatment (20% versus 3%; P = 0.03). The mean length of stay was 3.5 days less for patients who received extended infusion (P = 0.36), and for patients admitted to the intensive care unit the mean length of stay was significantly less in the extended-infusion group (18.5 days versus 8 days; P = 0.04). Hospital costs were $23,183 less per patient, favoring the extended-infusion treatment group (P = 0.13). We conclude that extended-infusion treatment with cefepime provides increased clinical and economic benefits in the treatment of invasive P. aeruginosa infections.

Bauer, Karri A.; West, Jessica E.; O'Brien, James M.

2013-01-01

292

The treatment of haemophilia, including prophylaxis, constant infusion and DDAVP.  

Science.gov (United States)

Recent years have witnessed advances in the treatment of haemophilia such as the introduction of prophylaxis, continuous infusion and pharmacological treatment with desmopressin (DDAVP). Prophylactic treatment on a long-term basis appears to be effective in preventing the development of arthropathy in severe haemophilia. The largest body of experience is that from Sweden, where prophylaxis is started at the age of 1-2 years. The dosage used is 25-40 U factor VIII/IX per kilogram bodyweight given three times or twice weekly, respectively. In some cases an intravenous access device has to be used during the first years of treatment. The patients grow up like normal boys and can live virtually normal lives. The beneficial psychological impact of prophylaxis on the family cannot be overestimated. Side-effects are not more frequent with prophylaxis than with on-demand treatment. The feasibility of continuous infusion of factor VIII/IX concentrates during bleeding episodes, or as cover for surgery, has been documented. This mode of delivery increases convenience and the cost-benefit ratio of the treatment, with savings in postoperative replacement of factor concentrate of about 50-75%. Many modern concentrates are stable enough for the purpose, and several pump systems, including portable ones, are available. The haemostatic drug DDAVP can be effectively used in most cases of mild haemophilia A. Intravenous administration is to be preferred as cover for surgery or in the case of severe bleeds. There is an effective nasal spray which can also be used for home therapy in mild or moderate bleedings. PMID:8800504

Berntorp, E

1996-06-01

293

Hydrophobic liquid-infused porous polymer surfaces for antibacterial applications.  

Science.gov (United States)

Biofilms represent a fundamental problem in environmental biology, water technology, food hygiene as well as in medical and technical systems. Recently introduced slippery liquid-infused porous surface (SLIPS) showed great promise for preventing biofilm formation owing to the low surface energy of such surface in combination with its self-cleaning properties. In this study we demonstrated a novel hydrophobic liquid-infused porous poly(butyl methacrylate-co-ethylene dimethacrylate) surface (slippery BMA-EDMA) with bacteria-resistance in BM2 mineral medium and long-term stability in aqueous environments. We showed that the slippery BMA-EDMA surface prevents biofilm formation of different strains of opportunistic pathogen Pseudomonas aeruginosa for at least up to 7 days in low nutrient medium. Only ?1.8% of the slippery surface was covered by the environmental P. aeruginosa PA49 strain under investigation. In uncoated glass controls the coverage of surfaces reached ?55% under the same conditions. However, in high nutrient medium, more relevant to physiological conditions, the biofilm formation on the slippery surface turned out to be highly dependent on the bacterial strain. Although the slippery surface could prevent biofilm formation of most of the P. aeruginosa strains tested (?1% surface coverage), the multiresistant P. aeruginosa strain isolated from wastewater was able to cover up to 12% of the surface during 7 days of incubation. RAPD-PCR analysis of the used P. aeruginosa strains demonstrated their high genome variability, which might be responsible for their difference in biofilm formation on the slippery BMA-EDMA surface. The results show that although the slippery BMA-EDMA surface has a great potential against biofilm formation, the generality of its bacteria resistant properties is still to be improved. PMID:23777668

Li, Junsheng; Kleintschek, Tanja; Rieder, Annika; Cheng, Yin; Baumbach, Tilo; Obst, Ursula; Schwartz, Thomas; Levkin, Pavel A

2013-07-24

294

Haemolytic anaemia as a complication to intravenous immunoglobulin infusion  

DEFF Research Database (Denmark)

Intravenous immunoglobulin (IVIg) is an established treatment for various neuromuscular disorders. Recently, we have observed a few cases of haemolytic anaemia following IVIg treatment. The objective of this study was to determine the extent of anaemia and haemolysis as a complication to IVIg. In a prospective study we included 28 post-polio patients treated with 2g per kilo of Privigen® and 22 CIDP patients treated with 1.7±0.4 (mean±SD) g per kilo of Kiovig®. The post-polio patients were all IVIg treatment naitive whereas the CIDP patients were in maintenance therapy. Venous blood samples were performed before and two weeks after infusion of IVIg. Following treatment blood haemoglobin declined from 8.6±0.8 to 8.1±1.3mmol/l, p<0.001. Furthermore, decreasing haptoglobin and increasing reticulocyte count, blood bilirubin, and lactate dehydrogenase were observed, all p<0.05. The decrease of haemoglobin was 0.79±1.2 in the treatment naive versus 0.25±0.3mmol/l in the long-term treated patients, p=0.05. Alterations of reticulocyte count, haptoglobin and lactate dehydrogenase were more pronounced in the treatment naive group, all p<0.05. In 7 patients we observed a substantial decline of haemoglobin of more than 1.5mmol/l (1.8-2.9). Six of those 7 patients had undetectable levels of haptoglobin after IVIg and the mean reticulocyte count, blood bilirubin and lactate dehydrogenase increased 420%, 130% and 108%. All were in the de-novo treated group. Our observations indicate that treatment naive patients are susceptible to develop haemolysis. Haemolytic anaemia is a severe side effect that seems to be more frequent after immunoglobulin infusions than previously recognized.

Markvardsen, Lars Høj; Harbo, Thomas

295

Process Optimization of Bismaleimide (BMI) Resin Infused Carbon Fiber Composite  

Science.gov (United States)

Bismaleimide (BMI) resins are an attractive new addition to world-wide composite applications. This type of thermosetting polyimide provides several unique characteristics such as excellent physical property retention at elevated temperatures and in wet environments, constant electrical properties over a vast array of temperature settings, and nonflammability properties as well. This makes BMI a popular choice in advance composites and electronics applications [I]. Bismaleimide-2 (BMI-2) resin was used to infuse intermediate modulus 7 (IM7) based carbon fiber. Two panel configurations consisting of 4 plies with [+45deg, 90deg]2 and [0deg]4 orientations were fabricated. For tensile testing, a [90deg]4 configuration was tested by rotating the [0deg]4 configirration to lie orthogonal with the load direction of the test fixture. Curing of the BMI-2/IM7 system utilized an optimal infusion process which focused on the integration of the manufacturer-recommended ramp rates,. hold times, and cure temperatures. Completion of the cure cycle for the BMI-2/IM7 composite yielded a product with multiple surface voids determined through visual and metallographic observation. Although the curing cycle was the same for the three panellayups, the surface voids that remained within the material post-cure were different in abundance, shape, and size. For tensile testing, the [0deg]4 layup had a 19.9% and 21.7% greater average tensile strain performance compared to the [90deg]4 and [+45deg, 90deg, 90deg,-45degg] layups, respectively, at failure. For tensile stress performance, the [0deg]4 layup had a 5.8% and 34.0% greater average performance% than the [90deg]4 and [+45deg, 90deg, 90deg,-45deg] layups.

Ehrlich, Joshua W.; Tate, LaNetra C.; Cox, Sarah B.; Taylor, Brian J.; Wright, M. Clara; Caraccio, Anne J.; Sampson, Jeffery W.

2013-01-01

296

Effects of lipid and propionic acid infusions on feed intake of lactating dairy cows.  

Science.gov (United States)

Propionic acid is more hypophagic for cows with elevated hepatic acetyl coenzyme A (CoA) concentration in the postpartum period. The objective of this experiment was to evaluate the interaction of hepatic acetyl CoA concentration, which is elevated by intravenous lipid infusion, and intraruminal propionic acid infusion on feed intake and feeding behavior responses of lactating cows. Eight multiparous, ruminally cannulated, Holstein dairy cows past peak lactation were used in a replicated 4×4 Latin square experiment with a 2×2 factorial arrangement of treatments. Treatments were propionic acid (PI) infused intraruminally at 0.5mol/h for 18h starting 6h before feeding and behavior monitoring or sham control (CO), and intravenous jugular infusion of lipid (LI, Intralipid 20%; Baxter US, Deerfield, IL) or saline (SI, 0.9% NaCl; Baxter US) infused at 250mL/h for 12h before feeding and behavior monitoring, and then 500mL/h for 12h after feeding. Changes in plasma concentrations of metabolites and hormones and hepatic acetyl CoA from before infusion until the end of infusion were evaluated. We observed a tendency for an interaction between PI and LI for the change in plasma nonesterified fatty acid (NEFA) concentration from the preliminary day to the end of the infusion period. Infusion of propionic acid decreased dry matter intake (DMI) 15% compared with CO, but lipid infusion did not affect DMI over the 12h following feeding. Infusion of propionic acid tended to decrease hepatic acetyl CoA concentration from the preliminary day to the end of the infusion compared with CO, consistent with PI decreasing DMI by stimulating oxidation of acetyl CoA. Contrary to our expectations, LI did not increase concentration of NEFA or ?-hydroxybutyrate in plasma, concentration of acetyl CoA in the liver, or milk fat yield, suggesting that the infused lipid was stored or oxidized by extra-hepatic tissues. As a result, we detected no interaction between PI and LI for DMI. Although the effect of PI on DMI was consistent with our previous results, this lipid infusion model using cows past peak lactation was not useful to simulate the lipolytic state of cows in the postpartum period in this experiment. PMID:24534511

Stocks, S E; Allen, M S

2014-04-01

297

Labetalol infusion for refractory hypertension causing severe hypotension and bradycardia: an issue of patient safety  

Science.gov (United States)

Incremental doses of intravenous labetalol are safe and effective and, at times, such therapy may need to be augmented by a continuous infusion of labetalol to control severe hypertension. Continuous infusions of labetalol may exceed the recommended maximum daily dose of 300 mg on occasion. We report a case in which hypertension occurring after an abdominal aortic aneurysm repair, initially responsive to intermittent intravenous beta-blockade, became resistant to this therapy leading to the choice of an intravenous labetalol infusion as the therapeutic option. The labetalol infusion resulted in a profound cardiovascular compromise in this postoperative critically ill patient. While infusions of labetalol have successfully been used, prolonged administration in the intensive care unit requires vigilance and the establishment of a therapeutic rationale/policy for interventions, such as the ready availability of glucagon, ?-agonists, phosphodiesterase inhibitors, insulin, and vasopressin when severe cardiovascular depression occurs.

Fahed, Samir; Grum, Daniel F; Papadimos, Thomas J

2008-01-01

298

Long-term BPA infusions. Evaluation in the rat brain tumor and rat spinal cord models  

Energy Technology Data Exchange (ETDEWEB)

In the BPA-based dose escalation clinical trial, the observations of tumor recurrence in areas of extremely high calculated tumor doses suggest that the BPA distribution is non-uniform. Longer (6-hour) i.v. infusions of BPA are evaluated in the rat brain tumor and spinal cord models to address the questions of whether long-term infusions are more effective against the tumor and whether long-term infusions are detrimental in the central nervous system. In the rat spinal cord, the 50% effective doses (ED{sub 50}) for myeloparesis were not significantly different after a single i.p. injection of BPA-fructose or a 6 hour i.v. infusion. In the rat 9L gliosarcoma brain tumor model, BNCT following 2-hr or 6-hr infusions of BPA-F produced similar levels of long term survival. (author)

Coderre, J.A.; Micca, P.L.; Nawrocky, M.M.; Joel, D.D. [Brookhaven National Laboratory, Medical Department, Upton, NY (United States); Morris, G.M. [University of Oxford, Research Institute, Oxford (United Kingdom)

2000-10-01

299

Labetalol infusion for refractory hypertension causing severe hypotension and bradycardia: an issue of patient safety  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Incremental doses of intravenous labetalol are safe and effective and, at times, such therapy may need to be augmented by a continuous infusion of labetalol to control severe hypertension. Continuous infusions of labetalol may exceed the recommended maximum daily dose of 300 mg on occasion. We report a case in which hypertension occurring after an abdominal aortic aneurysm repair, initially responsive to intermittent intravenous beta-blockade, became resistant to this therapy leading to the choice of an intravenous labetalol infusion as the therapeutic option. The labetalol infusion resulted in a profound cardiovascular compromise in this postoperative critically ill patient. While infusions of labetalol have successfully been used, prolonged administration in the intensive care unit requires vigilance and the establishment of a therapeutic rationale/policy for interventions, such as the ready availability of glucagon, ?-agonists, phosphodiesterase inhibitors, insulin, and vasopressin when severe cardiovascular depression occurs.

Papadimos Thomas J

2008-05-01

300

Determination of 210Po in tea, mat and their infusions and its annual intake by Syrians  

International Nuclear Information System (INIS)

Polonium-210 was determined in 34 kinds of imported tea and 9 kinds of mat collected from the Syrian local market. The 210Po concentration was found to vary from 5.5 to 39 Bq x kg-1 and 47 to 82 Bq x kg-1 in tea and mat samples, respectively. In addition 210Po was also determined in tea and mat infusions where different infusion conditions have been examined: amount, temperature and infusion time. The results have shown that the amount of 210Po transferred from tea and mat leaves to the aqueous extract ranged from 9 to 21% and 3 to 15%, respectively. The annual intake of 210Po by Syrians due to tea consumption and mat infusions was calculated and found to be 9 Bq and 151 Bq for tea and mat respectively: washing of mat with warm water is recommended before preparation the infusions to decrease the annual intake of 210Po. (author)

2004-04-01

 
 
 
 
301

Comparison of surface modifications of poly(ether urethanes) by chemical infusion and graft polymerization  

Energy Technology Data Exchange (ETDEWEB)

Our approach to surface modification uses the chemical infusion process to introduce materials into the outermost layer of the polymeric material, thereby altering the surface without changing the bulk properties of the polymer. The infused materials may slowly diffuse out of the infusion layer if they are volatile or highly mobile. However, if polymeric infusant materials are employed, they may become chain entangled with the host polymer and result in a permanently modified surface. A second approach utilizes photo-initiated graft polymerization of poly(ether urethanes) with an appropriate monomer. We have explored both of these methods by examining the infusion of polyvinylpyrrolidone (PVP) and poly(ethylene glycol) (PEG) into commercially available poly(ether urethanes) and the graft polymerization of N-vinyl pyrrolidone onto poly(ether urethanes). Results are presented here. 7 refs., 1 tab.

Wrobleski, D.A.; Cash, D.L.; Hermes, R.E.

1988-01-01

302

Boron biodistribution in Beagles after intravenous infusion of 4-dihydroxyborylphenylalanine-fructose complex  

Energy Technology Data Exchange (ETDEWEB)

Boron biodistribution after intravenous infusion of 4-dihydroxyborylphenylalanine-fructose (BPA-F) complex was investigated in six dogs. Blood samples were evaluated during and following doses of 205 and 250 mg/kgbw BPA in a 30 min infusion, and 500 mg/kgbw in a 1 h infusion. Samples from whole blood, urine, brain and other organs were analysed for boron content after varying times following the onset of infusion. The whole blood boron concentrations declined from 27 to 8.4 ppm over the period of 39-165 min after the onset of infusion and the levels increased from 1.9 to 12 ppm in the grey matter of the brain over the same period. The boron concentrations in whole blood decreased steadily, whereas the boron values in brain tissue rose steadily with time. It was concluded that whole blood boron concentrations do not seem to reflect accurately the boron concentration in brain tissue at respective time points.

Kulvik, M.E. E-mail: martti.kulvik@welho.com; Vaehaetalo, J.K.; Benczik, J.; Snellman, M.; Laakso, J.; Hermans, R.; Jaerviluoma, E.; Rasilainen, M.; Faerkkilae, M.; Kallio, M.E

2004-11-01

303

A computer designed graph for administration of atracurium by i.v. infusion.  

Science.gov (United States)

A bi-exponential mathematical computer model was used to develop a guidance graph for atracurium infusions. The model permitted variation in infusion rates, in pharmacokinetic parameters and in "effect" thresholds. Systematic experiments revealed a relationship between the rate of recovery from a fixed bolus loading dose and the most appropriate initial infusion rate. This relationship was expressed as a guidance graph or "ready reckoner". The quality of guidance was assessed in 50 anaesthetics, given consecutively. In 39 patients optimal myoneural block for surgery was maintained for the duration of the infusion without adjustments or supplementary bolus doses. The mean operating time was 92 min and the mean duration of infusion was 59 min. PMID:2265046

Simpson, D S; Souter, A J

1990-12-01

304

Attribute Based Selection of Thermoplastic Resin for Vacuum Infusion Process: A Decision Making Methodology  

DEFF Research Database (Denmark)

The composite industry looks toward a new material system (resins) based on thermoplastic polymers for the vacuum infusion process, similar to the infusion process using thermosetting polymers. A large number of thermoplastics are available in the market with a variety of properties suitable for different engineering applications, and few of those are available in a not yet polymerised form suitable for resin infusion. The proper selection of a new resin system among these thermoplastic polymers is a concern for manufactures in the current scenario and a special mathematical tool would be beneficial. In this paper, the authors introduce a new decision making tool for resin selection based on significant attributes. This article provides a broad overview of suitable thermoplastic material systems for vacuum infusion process available in todayâ??s market. An illustrative exampleâ??resin selection for vacuum infused of a wind turbine bladeâ??is shown to demonstrate the intricacies involved in the proposed methodology for resin selection.

Raghavalu Thirumalai, Durai Prabhakaran; Lystrup, Aage

2012-01-01

305

Sincalide cholescintigraphy--32 years later: evidence-based data on its clinical utility and infusion methodology.  

Science.gov (United States)

Sincalide cholescintigraphy was first reported to have clinical utility in 1980. Since then, many publications have found that a reduced gallbladder ejection fraction (GBEF) can confirm the clinical diagnosis of acalculous chronic gallbladder disease and predict symptomatic relief with cholecystectomy. However, some publications had not found the test clinically predictive. Many different sincalide infusion methods and normal values have been used. It had been suspected that the different infusion methods and normal values might account for the variability in reported utility. Furthermore, clinical review articles have raised questions about the evidence-based quality of the published data on the diagnostic utility of sincalide cholescintigraphy. A recently published multicenter trial has established the optimal methodology for sincalide infusion and normal values. A subsequent multispecialty consensus publication has recommended that this method be the standard method for sincalide infusion, specifically, a 60-minute infusion of 0.02 ?g/kg (abnormal GBEF, gallbladder disease and the patient's response to cholecystectomy. PMID:22293163

Ziessman, Harvey A

2012-03-01

306

Attribute based selection of thermoplastic resin for vacuum infusion process : A decision making methodology  

DEFF Research Database (Denmark)

The composite industry looks toward a new material system (resins) based on thermoplastic polymers for the vacuum infusion process, similar to the infusion process using thermosetting polymers. A large number of thermoplastics are available in the market with a variety of properties suitable for different engineering applications, and few of those are available in a not yet polymerised form suitable for resin infusion. The proper selection of a new resin system among these thermoplastic polymers is a concern for manufactures in the current scenario and a special mathematical tool would be beneficial. In this paper, the authors introduce a new decision making tool for resin selection based on significant attributes. This article provides a broad overview of suitable thermoplastic material systems for vacuum infusion process available in todayâ??s market. An illustrative exampleâ??resin selection for vacuum infused of a wind turbine bladeâ??is shown to demonstrate the intricacies involved in the proposed methodology for resin selection.

Prabhakaran, R.T. Durai; Lystrup, Aage

2011-01-01

307

Mineral Analysis the Infusion of Black Tea Samples by Atomic Absorption Spectrometry  

Directory of Open Access Journals (Sweden)

Full Text Available Tea infusion is one of the most popular drinks around the world. Since tea infusion is known to contain several essential nutrients, it is considered a healthy beverage. In this study eight different Iranian brands of tea infusion and eleven brands imported tea infusion samples from another country for Cu, Zn, Mn and Al were determined by flame atomic absorption spectrometry after wet digestion. The results of analysis showed that the extraction rates of minerals from dry black tea to infusion tea were for Mn (19.35%, Cu (22.75%, Zn (54.43% and Al (61.48%. The results obtained from this analysis have shown good accuracy.

Lahiji N.

2013-04-01

308

Successful intraosseous infusion in the critically ill patient does not require a medullary cavity.  

LENUS (Irish Health Repository)

OBJECTIVES: To demonstrate that successful intraosseous infusion in critically ill patients does not require bone that contains a medullary cavity. DESIGN: Infusion of methyl green dye via standard intraosseous needles into bones without medullary cavity-in this case calcaneus and radial styloid-in cadaveric specimens. SETTING: University department of anatomy. PARTICIPANTS: Two adult cadaveric specimens. MAIN OUTCOME MEASURES: Observation of methyl green dye in peripheral veins of the limb in which the intraosseous infusion was performed. RESULTS: Methyl green dye was observed in peripheral veins of the chosen limb in five out of eight intraosseous infusions into bones without medullary cavity-calcaneus and radial styloid. CONCLUSIONS: Successful intraosseous infusion does not always require injection into a bone with a medullary cavity. Practitioners attempting intraosseous access on critically ill patients in the emergency department or prehospital setting need not restrict themselves to such bones. Calcaneus and radial styloid are both an acceptable alternative to traditional recommended sites.

McCarthy, Gerard

2012-02-03

309

Artemisia absinthium and Artemisia vulgaris: a comparative study of infusion polysaccharides.  

Science.gov (United States)

The aerial parts of Artemisia absinthium and Artemisia vulgaris are used in infusions for the treatment of several diseases. Besides secondary metabolites, carbohydrates are also extracted with hot water and are present in the infusions. The plant carbohydrates exhibit several of therapeutic properties and their biological functions are related to chemical structure. In this study, the polysaccharides from infusions of the aerial parts of A. absinthium and A. vulgaris were isolated and characterized. In the A. absinthium infusion, a type II arabinogalactan was isolated. The polysaccharide had a Gal:Ara ratio of 2.3:1, and most of the galactose was (1 ? 3)- and (1 ? 6)-linked, as typically found in type II arabinogalactans. In the A. vulgaris infusion, an inulin-type fructan was the main polysaccharide. NMR analysis confirmed the structure of the polymer, which is composed of a chain of fructosyl units ?-(2 ? 1) linked to a starting ?-d-glucose unit. PMID:24507342

Corrêa-Ferreira, Marília Locatelli; Noleto, Guilhermina Rodrigues; Oliveira Petkowicz, Carmen Lúcia

2014-02-15

310

Systemic and regional hemodynamic effects of enalaprilat infusion in experimental normotensive sepsis  

Directory of Open Access Journals (Sweden)

Full Text Available Angiotensin-converting enzyme inhibitors have been shown to improve splanchnic perfusion in distinct shock states. We hypothesized that enalaprilat potentiates the benefits of early fluid resuscitation in severe experimental sepsis, particularly in the splanchnic region. Anesthetized and mechanically ventilated mongrel dogs received an intravenous infusion of live Escherichia coli over a period of 30 min. Thereafter, two interventions were performed: fluid infusion (normal saline, 32 mL/kg over 30 min and enalaprilat infusion (0.02 mg kg-1 min-1 for 60 min in randomized groups. The following groups were studied: controls (fluid infusion, N = 4, E1 (enalaprilat infusion followed by fluid infusion, N = 5 and E2 (fluid infusion followed by enalaprilat infusion, N = 5. All animals were observed for a 120 min after bacterial infusion. Mean arterial pressure, cardiac output (CO, portal vein blood flow (PVBF, systemic and regional oxygen-derived variables, and lactate levels were measured. Rapid and progressive reductions in CO and PVBF were induced by the infusion of live bacteria, while minor changes were observed in mean arterial pressure. Systemic and regional territories showed a significant increase in oxygen extraction and lactate levels. Widening venous-arterial and portal-arterial pCO2 gradients were also detected. Fluid replacement promoted transient benefits in CO and PVBF. Enalaprilat after fluid resuscitation did not affect systemic or regional hemodynamic variables. We conclude that in this model of normotensive sepsis inhibition of angiotensin-converting enzyme did not interfere with the course of systemic or regional hemodynamic and oxygen-derived variables.

Rahal L.

2006-01-01

311

Physiology of Body Water and Salt Regulation. Part 2: Volume and Electrolyte Homeostasis after an Acute Saline Infusion.  

Science.gov (United States)

Six healthy male volunteers were investigated under strictly controlled conditions to determine the renal and hormonal responses to an acute isotonic saline infusion. During a nine day study in recumbent body position, the volunteers received an infusion ...

C. Drummer M. Heer B. Molz M. Schlossberger C. Stadeager

1990-01-01

312

Is routine replacement of i.v. administration sets required after each change of intermittently administrated antibiotic infusions?  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Aim: Manufacturers' instructions recommend changing the infusion line together with the infusion bottle after each administration. We investigated if the complete infusion line may be microbiologically contaminated after short-time antibiotic and rinse-solution application.Method: Immediately after the change of an infusion administration set after 72 hours the remaining antibiotic solution was inactivated with yolk and cultured on blood agar for 48 hours at 36°C to detect possible contami...

Von Au, F.; Ryll, S.; Wegner, C.; Gessner, S.; Kramer, A.

2013-01-01

313

Is routine replacement of i.v. administration sets required after each change of intermittently administrated antibiotic infusions?  

Directory of Open Access Journals (Sweden)

Full Text Available [english] Aim: Manufacturers’ instructions recommend changing the infusion line together with the infusion bottle after each administration. We investigated if the complete infusion line may be microbiologically contaminated after short-time antibiotic and rinse-solution application.Method: Immediately after the change of an infusion administration set after 72 hours the remaining antibiotic solution was inactivated with yolk and cultured on blood agar for 48 hours at 36°C to detect possible contaminants.Results: Among 87 investigated samples no microbial growth was detected. One sample which hadn’t any contact to antibiotics yielded forming unit (cfu of coagulase-negative staphylococci.These results suggest that in case of consecutive antibiotic-short- and rinse-infusions the infusion line may be in place up to 72 hours without contamination. This, however, may be only the case for infusion sets, which are in contact with antibiotics. If no antibiotic is administered, the infusion bottle and the infusion line must be renewed together for every change. To clarify this question into more detail, a larger consecutive study is required. Conclusion: I.v. administration sets without any contact to antibiotics must be changed together with their infusion bottle after administration. In case of consecutive antibiotic-short- and rinse-infusions our pilot study suggests using the i.v. administration sets for up to 72 hours without renewing it at every infusion-set exchange.

von Au, Felix

2013-04-01

314

Evaluating the Safety and Efficiency of a CPOE System for Continuous Medication Infusions in a Pediatric ICU  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Critically ill children often require continuous intravenous infusions of life-supporting medications. The complexity of ordering such infusions makes this an error prone process, and such errors can result in serious adverse events. A CPOE system was developed and evaluated to assess its impact on the safety and efficiency of prescribing continuous medication infusions.

Vaidya, Vinay; Sowan, Azizeh K.; Mills, Mary Etta; Soeken, Karen; Gaffoor, Mohamed; Hilmas, Elora

2006-01-01

315

Phase I clinical trial of continuous infusion cyclopentenyl cytosine.  

Science.gov (United States)

Cyclopentenyl cytosine (CPE-C) is an investigational drug that is active against human solid tumor xenografts. The 5'-triphosphate of CPE-C inhibits CTP synthase, and depletes CTP and dCTP pools. We conducted a phase I clinical trial of CPE-C given as a 24-h continuous i.v. infusion every 3 weeks in 26 adults with solid tumors. The starting dose rate, 1 mg/m2 per h, was selected on the basis of both preclinical studies and pharmacokinetic data from two patients obtained after a test dose of 24 mg/m2 CPE-C as an i.v. bolus. Dose escalation was guided by clinical toxicity. A total of 87 cycles were given, and ten patients received four or more cycles. The mean CPE-C steady-state plasma levels (Cpss) increased linearly from 0.4 microM to 3.1 microM at dose levels ranging from 1 to 5.9 mg/m2 per h (actual body weight); the mean total body clearance was 146 +/- 38 ml/min per m2. CPE-C was eliminated by both renal excretion of intact drug and deamination to cyclopentenyl uracil in an apparent 2:1 ratio. CTP synthase activity in intact bone marrow mononuclear cells was inhibited by 58% to 100% at 22 h compared to matched pretreatment samples at all CPE-C dose levels. When all data were combined, flux through CTP synthase was decreased by 89.6% +/- 3.1% at 22 h (mean +/- SE, n = 16), and remained inhibited by 67.6% +/- 7.7% (n = 10) for at least 24 h post-CPE-C infusion. Granulocyte and platelet toxicities were dose-dependent, and dose-limiting myelosuppression occurred during the initial cycle in two of three patients treated with 5.9 mg/m2 per h. Four of 11 patients (4 of 20 cycles) who received 4.7 mg/m2 per h CPE-C experienced hypotension 24-48 h after completion of the CPE-C infusion during their first (n = 2), third (n = 1) and sixth cycles (n = 1), respectively. Two of these patients died with refractory hypotension despite aggressive hydration and cardiopulmonary resuscitation. One of 12 patients (28 total cycles) treated with 3.5 mg/m2 per h CPE-C experienced orthostatic hypotension during cycle 1, and this patient had a second episode of orthostatic hypotension at a lower dose (3.0 mg/m2 per h). Hypotension was not seen in patients receiving < or = 2.5 mg/m2 per h CPE-C.(ABSTRACT TRUNCATED AT 400 WORDS) PMID:7554044

Politi, P M; Xie, F; Dahut, W; Ford, H; Kelley, J A; Bastian, A; Setser, A; Allegra, C J; Chen, A P; Hamilton, J M

1995-01-01

316

Transfer of difenoconazole and azoxystrobin residues from chrysanthemum flower tea to its infusion.  

Science.gov (United States)

Investigations of the transfer of pesticide residues from tea to its infusion can be important in the assessment of the possible health benefits of tea consumption. In this work the transfer of difenoconazole and azoxystrobin residues from chrysanthemum tea to its infusion was investigated at different water temperatures, infusion intervals and times. The transfer percentages were in the range of 18.7-51.6% for difenoconazole and of 38.1-71.2% for azoxystrobin, and increased considerably with longer infusion intervals. The results indicated that azoxystrobin with a lower octanol-water partition coefficient of 2.5, showed a higher transfer than that of difenoconazole with a relatively high octanol-water partition coefficient of 4.4. Water temperature had no significant effect on the transfer of the two residues, and no obvious loss of difenoconazole and azoxystrobin occurred during the infusion process. The concentrations in the infusions decreased gradually from 0.67 to 0.30 ?g kg(-1) for difenoconazole and from 2.3 to 0.46 ?g kg(-1) for azoxystrobin after five infusions. To assess the potential health risk, the values of estimate expose risk were calculated to be 0.016 for difenoconazole and 0.0022 for azoxystrobin, meaning the daily residue intake of the two analytes from chrysanthemum tea was safe. This research may help assure food safety and identify the potential exposure risks from pesticides in chrysanthemum that may be health concerns. PMID:24405376

Xue, Jiaying; Li, Huichen; Liu, Fengmao; Xue, Jian; Chen, Xiaochu; Zhan, Jing

2014-04-01

317

Choice of infusion-sampling mode for tracer studies of free fatty acid metabolism  

Energy Technology Data Exchange (ETDEWEB)

To determine the preferred infusion-sampling mode for isotopic studies of free fatty acid (FFA) metabolism, tracer ((/sup 14/C)palmitate) was infused into the left ventricle of five anesthetized dogs, and tracee ((/sup 3/H)palmitate) was infused into three separate peripheral veins of each dog. The (/sup 14/C)palmitate specific activity (SA) was lower in mixed venous than arterial blood, and (/sup 3/H)palmitate SA was equal in both sites. The actual infusion rate of (/sup 3/H)palmitate (2.15 +/- 0.31 X 10(5) disintegrations/min (dpm).kg-1.min-1) could be accurately predicted (2.14 +/- 0.32 X 10(5) dpm.kg-1.min-1) using the known (/sup 14/C)palmitate infusion rate and the arterial plasma (/sup 14/C)-to-(/sup 3/H)palmitate ratio. In contrast, the mixed venous (/sup 14/C)-to-(/sup 3/H)palmitate ratio resulted in overestimates (P less than 0.05) of the actual (/sup 3/H)palmitate infusion rate. In summary, venous tracer infusion with arterial blood sampling for FFA tracer studies provides the most accurate estimates of tracee rate of appearance.

Jensen, M.D.; Rogers, P.J.; Ellman, M.G.; Miles, J.M.

1988-05-01

318

Value of infusion-DSA (Digital Subtraction Angiography) in diagnosis of primary hepatocellular carcinoma  

Energy Technology Data Exchange (ETDEWEB)

In order to evaluate diagnostic effectiveness of the infusion-study, the authors prospectively evaluated hepatic digital subtraction angiography of bolus and infusion studies in 71 patients with hepatocellular carcinoma. In contrast to Bolus-DSA, which involves a 2 second injection of 10cc of contrast medium, the Infusion-DSA uses a protracted (10sec) injection, a lower injection rate, and larger total dose of contrast medium (20cc). The information yield of arterial and capillary phases of Infusion-DSA was compared with that of Bolus-DSA and graded as 'improved(+)', 'equivalent( {+-} )', or 'poor(-)'. Also, the contribution of Infusion-DSA to the diagnosis was classified into one of five in a graded system. In 29 hepatocellular patients, the Infusion-DSA was helpful in detecting daughter nodules, fibrous capsule and arteriovenous shunt. Infusion-DSA is a useful complementary technique in the diagnosis of hepatocellular carcinoma and was also helpful in determining the selection of the therapeutic modality of hepatocellular carcinoma.

Kwon, Jeong Mi; Kim, So Sun; Huh, Jin Do; Kim, Ho Joon; Chun, Byung Hee; Joh, Young Duk [Kosin Medical College, Busan (Korea, Republic of)

1991-09-15

319

Glucagon infusion increases rate of purine synthesis de novo in rat liver  

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Based on the parallel increases of glucagon, the second peak of hepatic cAMP, and the rate of purine synthesis de novo in the prereplicative period in regenerating rate liver after a 70% hepatectomy, it was hypothesized that glucagon is responsible for the increased rate of purine synthesis de novo. To test this hypothesis, the effect of glucagon or dibutyryl cAMP infusion on the rate of purine synthesis de novo in rat liver was studied. Glucagon infusion but not insulin or glucose infusion increased the rate of purine synthesis de novo, which was assayed by ({sup 14}C)glycine or ({sup 14}C)formate incorporation, by 2.7- to 4.3-fold. Glucagon infusion increased cAMP concentrations by 4.9-fold and 5-phosphoribosyl-1-pyrophosphate concentrations by 1.5-fold in liver but did not change the specific activity of amidophosphoribosyltransferase or purine ribonucleotide concentrations. Dibutyryl cAMP infusion also increased the rate of purine synthesis de novo by 2.2- to 4.0-fold. Because glucagon infusion increased the rate of purine synthesis de novo in the presence of unchanged purine ribonucleotide concentrations, it is concluded that glucagon after infusion or in animals after a 70% hepatectomy is playing an anabolic role to increase the rate of purine synthesis de novo by increasing cAMP and 5-phosphoribosyl-1-pyrophosphate concentrations.

Itakura, Mitsuo; Maeda, Noriaki; Tsuchiya, Masami; Yamashita, Kamejiro (Univ. of Tsukuba, Ibaraki (Japan))

1987-12-01

320

Glucagon infusion increases rate of purine synthesis de novo in rat liver  

International Nuclear Information System (INIS)

Based on the parallel increases of glucagon, the second peak of hepatic cAMP, and the rate of purine synthesis de novo in the prereplicative period in regenerating rate liver after a 70% hepatectomy, it was hypothesized that glucagon is responsible for the increased rate of purine synthesis de novo. To test this hypothesis, the effect of glucagon or dibutyryl cAMP infusion on the rate of purine synthesis de novo in rat liver was studied. Glucagon infusion but not insulin or glucose infusion increased the rate of purine synthesis de novo, which was assayed by [14C]glycine or [14C]formate incorporation, by 2.7- to 4.3-fold. Glucagon infusion increased cAMP concentrations by 4.9-fold and 5-phosphoribosyl-1-pyrophosphate concentrations by 1.5-fold in liver but did not change the specific activity of amidophosphoribosyltransferase or purine ribonucleotide concentrations. Dibutyryl cAMP infusion also increased the rate of purine synthesis de novo by 2.2- to 4.0-fold. Because glucagon infusion increased the rate of purine synthesis de novo in the presence of unchanged purine ribonucleotide concentrations, it is concluded that glucagon after infusion or in animals after a 70% hepatectomy is playing an anabolic role to increase the rate of purine synthesis de novo by increasing cAMP and 5-phosphoribosyl-1-pyrophosphate concentrations

1987-01-01

 
 
 
 
321

Value of infusion-DSA (Digital Subtraction Angiography) in diagnosis of primary hepatocellular carcinoma  

International Nuclear Information System (INIS)

In order to evaluate diagnostic effectiveness of the infusion-study, the authors prospectively evaluated hepatic digital subtraction angiography of bolus and infusion studies in 71 patients with hepatocellular carcinoma. In contrast to Bolus-DSA, which involves a 2 second injection of 10cc of contrast medium, the Infusion-DSA uses a protracted (10sec) injection, a lower injection rate, and larger total dose of contrast medium (20cc). The information yield of arterial and capillary phases of Infusion-DSA was compared with that of Bolus-DSA and graded as 'improved(+)', 'equivalent( ± )', or 'poor(-)'. Also, the contribution of Infusion-DSA to the diagnosis was classified into one of five in a graded system. In 29 hepatocellular patients, the Infusion-DSA was helpful in detecting daughter nodules, fibrous capsule and arteriovenous shunt. Infusion-DSA is a useful complementary technique in the diagnosis of hepatocellular carcinoma and was also helpful in determining the selection of the therapeutic modality of hepatocellular carcinoma

1991-09-01

322

C-Section  

Medline Plus

Full Text Available ... unexpected problems happen during labor. The most common reasons for a C-section are: 1. The baby ... doctor could suggest a C-section for various reasons. However, in some of these cases, a normal ...

323

Cesarean Section Birth  

Medline Plus

Full Text Available ... cesarean sections sometimes have a good bit of scar tissue. Sometimes there's really not a whole lot there. ... section, there's an increased risk of there being scar tissue, which may increase the patient's risk for complications ...

324

Cesarean Section Birth  

Medline Plus

Full Text Available ... JODI JACKSON, MD: Anytime that you have a c-section delivery without labor, there's an increased risk ... important to think about the reasons why a c-section is indicated. The literature suggests that once ...

325

C-Section  

Medline Plus

Full Text Available ... 1 out of 4 women in the United States deliver their babies via C-sections. That is ... one million deliveries every year in the United States. Most C-sections are done when unexpected problems ...

326

Cesarean Section Birth  

Medline Plus

Full Text Available ... established a regional anesthetic on Kristen so that she could be nice and comfortable during the procedure. ... her. Kristen's having a repeat cesarean section because she had to have a cesarean section with her ...

327

Proteolytic and proteomic changes in milk at quarter level following infusion with Escherichia coli lipopolysaccharide.  

Science.gov (United States)

Mastitis is a major disease in dairy cattle, which causes significant economic losses due to decreased milk production, veterinary costs, and discarded milk. Escherichia coli is one of the most prevalent species of gram-negative bacteria that induce clinical mastitis. The objective of the present study was to characterize the proteolytic and proteomic changes in milk in response to infusion with lipopolysaccharide (LPS) at quarter level in a model mastitis system. One quarter of each of 2 cows was infused with 0.1 or 5 ?g of LPS. The somatic cell count of the infused quarters reached a peak 6 h after infusion to a greater extent in the cow infused with 5 ?g of LPS and changes in plasmin activity in milk differed between the 2 animals. Urea-polyacrylamide gel electrophoretograms of milk samples of the cow infused with 5 ?g of LPS obtained at different time points after infusion and incubated for up to 7 d showed almost full hydrolysis of ?- and ?(s1)-casein during incubation of milk samples due to indigenous proteolytic activity. Two-dimensional gel electrophoretograms of milk at 0, 6, or 12 h after infusion with LPS showed hydrolysis of ?(s)-casein and ?-casein as well as the appearance of lower molecular weight products. Eleven fragments from proteolysis of the caseins were identified by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and, in addition, proteolysis patterns of casein by the indigenous bovine milk proteases plasmin and cathepsin D were studied in model studies using 2-dimensional gel electrophoretograms. Twelve hours after infusion, lower abundance markers of inflammation were identified, including serotransferrin, fibrinogen ? chain, protein S100 A12, and the antimicrobial polypeptide cathelicidin. PMID:22459814

Hinz, K; Larsen, L B; Wellnitz, O; Bruckmaier, R M; Kelly, A L

2012-04-01

328

Influences of brain tissue poroelastic constants on intracranial pressure (ICP) during constant-rate infusion.  

Science.gov (United States)

A 3D finite element (FE) model has been developed to study the mean intracranial pressure (ICP) response during constant-rate infusion using linear poroelasticity. Due to the uncertainties in the poroelastic constants for brain tissue, the influence of each of the main parameters on the transient ICP infusion curve was studied. As a prerequisite for transient analysis, steady-state simulations were performed first. The simulated steady-state pressure distribution in the brain tissue for a normal cerebrospinal fluid (CSF) circulation system showed good correlation with experiments from the literature. Furthermore, steady-state ICP closely followed the infusion experiments at different infusion rates. The verified steady-state models then served as a baseline for the subsequent transient models. For transient analysis, the simulated ICP shows a similar tendency to that found in the experiments, however, different values of the poroelastic constants have a significant effect on the infusion curve. The influence of the main poroelastic parameters including the Biot coefficient ?, Skempton coefficient B, drained Young's modulus E, Poisson's ratio ?, permeability ?, CSF absorption conductance C(b) and external venous pressure p(b) was studied to investigate the influence on the pressure response. It was found that the value of the specific storage term S(?) is the dominant factor that influences the infusion curve, and the drained Young's modulus E was identified as the dominant parameter second to S(?). Based on the simulated infusion curves from the FE model, artificial neural network (ANN) was used to find an optimised parameter set that best fit the experimental curve. The infusion curves from both the FE simulation and using ANN confirmed the limitation of linear poroelasticity in modelling the transient constant-rate infusion. PMID:22452461

Li, Xiaogai; von Holst, Hans; Kleiven, Svein

2013-01-01

329

Controlled studies of a new microprocessor-based portable infusion pump.  

Science.gov (United States)

A new microprocessor-controlled portable infusion pump, the Pancretec Provider IV 2000 TM was tested in vitro and in vivo in cancer patients. The Provider is a rotary peristaltic, battery-powered pump capable of flow rates of 0.2 to 83 ml/hour with delivery volumes up to 1999 ml. Two programming modes are available: intermittent infusion and continuous infusion. Bench tests showed the flow rate accuracy to be within 96% of the desired rate. Flow rate precision was similarly excellent at +/- 2%. Clinical studies were performed in 14 ambulatory patients receiving continuous infusion antineoplastic or analgesic drugs over 5-60 days as outpatients. The majority of infusions delivered fluoropyrimidines via indwelling central venous access ports. Two of the patients received long term (60 days) continuous infusion of analgesics for pain control. Flow rate accuracy with the pumps was within +/- 5% in 90% of the 27 infusion courses (244 patient-days of continuous infusion therapy). A significant therapy deviation (interruption 10% of the desired course) occurred in three instances. One related to a procedural error (incomplete cartridge insertion into the pump), two were caused by fluid leakage which interrupted pump function. Defect alarms (both visual and audible) operated in both instances. A KVO flow rate of 0.1 ml/hr was also found to be adequate to maintain catheter patency in peripheral veins over a 24-hour period in two normal volunteers. We conclude that the Provider pump is an accurate, reliable and state of the art infusion system with wide clinical applicability. PMID:3708536

Dorr, R T; Salmon, S E; Marsh, M E; Robertone, A

1986-01-01

330

Evaluation of efficacy and tolerability of fixed dose combination of ofloxacin with ornidazole infusion (infusion O2) in the management of diarrhoea and dysentery.  

Science.gov (United States)

Acute diarrhoea in adults is one of the most commonly encountered medical emergency in general practice and is responsible for considerable morbidity around the world. To evaluate the efficacy and tolerability of fixed dose combination of ofloxacin with ornidazole infusion (infusion O2) in the management of diarrhoea and dysentery, a study was carried out among 290 patients, age group from 18 to 65 years suffering from diarrhoea, dysentery, gastro-enteritis. Study drug infusion O2, (Medley Pharmaceutical, Mumbai) containing ofloxacin 200 mg + ornidazole 500 mg was administrated twice daily for a duration of 5 days. Number of soft or watery stool, body temperature, nausea, abdominal pain, gas and flatulence were recorded at baseline and at the end of the study. Tolerability and efficacy was evaluated based on the global assessment by the investigator based on a 3-point scale marked as excellent/good/poor. Two hundred and fifty-six-patients (160 male and 96 female) were included for final analysis, 34 patients lost to follow-up. Mean number of watery stool per day was reduced from 9.273 +/- 0.4537 to 1.375 +/- 0.07001 (p ofloxacin with ornidazole infusion (infusion O2) significantly reduces number of watery stool and associated symptoms like nausea, abdominal pain, flatulence/gas with excellent tolerability. PMID:23029956

Faruqui, Arif A; Joshi, Chandrakant

2012-03-01

331

C-Section  

Medline Plus

Full Text Available ... is rare for the outer scar of a C-section to be unsightly. However, internal and external scarring may ... a C-Section The hospital stay after a C-section is 3 to 4 days. It is a little longer than ...

332

Treatment of lung cancer with bronchial artery infusion of cisplatin and intravenous sodium thiosulfate rescue  

International Nuclear Information System (INIS)

Forty-nine patients with primary lung cancer were treated with bronchial artery infusion of cisplatin and intravenous injection of an antidote, sodium thiosulfate. More than 50% reduction of tumor size (PR) was observed in 8 of 9 small cell carcinomas (SCLC) and in 16 of 40 non-small cell carcinomas (NSCLC). In NSCLC patients PR was obtained in 71% (12/17) after repeated infusions (? 200 mg cisplatin) and in 17% (4/23) after a single infusion (? 150 mg cisplatin). There was a significant linear relationship between cisplatin dose and tumor reduction in this group. No severe adverse effects were encountered. (orig.)

1988-01-01

333

Sub-Acute Toxicity Studies of Paracetamol Infusion in Albino Wistar Rats  

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Full Text Available The objective of the present study was to evaluate the sub-acute toxicity of paracetamol infusion in albino wistar rats (male and female at different dose levels, ranging from 16 to 66 mg/kg body weight. No mortality was seen in any of the treatment groups during the course of study. Various physiological, hematological as well as biochemical parameters were studied and found not to be changed significantly, indicating that paracetamol infusion is non toxic even at higher dose level in wistar rats. Overall safety and tolerability profile of paracetamol infusion is proved good and does not appear to carry risk of serious adverse effects.

Anurag Payasi

2010-04-01

334

Development of nitrogen infusion technology for fighting and inhibition of fires  

Energy Technology Data Exchange (ETDEWEB)

Development of nitrogen infusion technology for fighting and inhibition of fires is discussed the main topics included are: the principle of inhibition of spontaneous combustion, the practice of nitrogen infusion in France, implementation of nitrogen infusion at Kotadih colliery, the quality of nitrogen required/proposed to be flushed, safety aspects for face workers, installation of an inert gas generator at Laikdah deep colliery, the cost of inert gas, the principle and description of a pressure-swing-absorption based nitrogen plant, liquid nitrogen versus gaseous nitrogen and proposed modifications and improvements to the processes.

Garg, P.C.

1987-08-01

335

Double-blind randomized study of the effect of infusion rates on toxicity of amphotericin B.  

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Results of a double-blind randomized non-crossover study of rapid (45 min) versus slow (4 h) infusion of amphotericin B administered to 20 patients with proven or suspected fungal infection are reported. Toxicity was higher in the rapid infusion group than it was in the slow infusion group (mean total 7-day chill score, 173 +/- 276 versus 20 +/- 30 [P less than 0.01]; mean total 7-day dosage of meperidine required to abate rigors, 180 +/- 133 versus 58 +/- 78 mg [P less than 0.05]; and mean m...

1992-01-01

336

Augmentation of endogenous intrarenal angiotensin II levels in Val5-ANG II-infused rats  

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In angiotensin II (ANG II)-induced hypertension, intrarenal ANG II levels are increased by AT1 receptor-mediated ANG II internalization and endogenous ANG II generation. The objective of the present study was to determine the relative contribution of de novo formation of endogenous ANG II. Male Sprague-Dawley rats were divided into three groups: sham operated (n = 6), Val5-ANG II infused (n = 16), and Ile5-ANG II infused (n = 6). Val5-ANG II and Ile5-ANG II were infused at 80 ng/min via subcu...

Shao, Weijian; Seth, Dale M.; Navar, L. Gabriel

2009-01-01

337

Circulating interleukin 6 during a continuous infusion of tumor necrosis factor and interferon gamma  

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Plasma samples obtained from patients receiving a 24-h continuous infusion of human recombinant (hr)TNF or a combination of two overlapping, 24-h continuous infusions of hrIFN-gamma and hrTNF were analyzed for IL-6 in a sensitive bioassay. A transient appearance of circulating IL-6 was observed with peak levels between 3 and 6 h after the start of the hrTNF infusion. These peak levels correlated quite well with the dose of hrTNF administered (r = 0.86; p less than 0.001). The maximal value ob...

1989-01-01

338

The disposition of bupivacaine following a 72 h interpleural infusion in cholecystectomy patients.  

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The disposition of bupivacaine and degree of analgesia following a 72 h interpleural infusion was investigated in 12 adult patients undergoing elective cholecystectomy. The infusion regimen of an initial interpleural bolus dose of 20 ml of 0.5% bupivacaine HCl with adrenaline (1:200,000) followed by continuous infusion at a rate of 8 ml h-1 of 0.25% plain bupivacaine HCl was designed to achieve continuous post-operative pain relief for 72 h. In practice an additional bolus dose (identical to ...

Kastrissios, H.; Triggs, E. J.; Mogg, G. A.; Higbie, J. W.

1991-01-01

339

Short versus Long Infusion of Meropenem in Very-Low-Birth-Weight Neonates  

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Prolonged infusion of meropenem has been suggested in studies with population pharmacokinetic modeling but has not been tested in neonates. We compared the steady-state pharmacokinetics (PK) of meropenem given as a short (30-min) or prolonged (4-h) infusion to very-low-birth-weight (gestational age, <32 weeks; birth weight, <1,200 g) neonates to define the appropriate dosing regimen for a phase 3 efficacy study. Short (n = 9) or prolonged (n = 10) infusions of meropenem were given at a dose o...

Padari, Helgi; Metsvaht, Tuuli; Ko?rgvee, Lenne-triin; Germovsek, Eva; Ilmoja, Mari-liis; Kipper, Karin; Herodes, Koit; Standing, Joseph F.; Oselin, Kersti; Lutsar, Irja

2012-01-01

340

Outcome Evaluation of Intravenous Infusion of Urokinase for Acute Ischemic Stroke  

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The aim of this study was to evaluate the clinical effect of a continuous infusion of urokinase in cerebral stoke patients who were late admitted over 6 hours after onset. From January to December in 2008, acute cerebral stroke patients (n=143) treated with intravenous urokinase infusion (Group I, n=93) or not (Group II, n=50) after 6 hours and within 72 hours of stroke onset were reviewed. Continuous intravenous infusion of urokinase was done for 5 days. The clinical outcome for each patient...

Lee, Rae Seop; Ok, Young Chul; Lim, Jun Seob; Lim, Byung Chan; Cho, Kyu Yong; Lee, Min Cheol

2012-01-01

 
 
 
 
341

Short versus Long Infusion of Meropenem in Very-Low-Birth-Weight Neonates  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Prolonged infusion of meropenem has been suggested in studies with population pharmacokinetic modeling but has not been tested in neonates. We compared the steady-state pharmacokinetics (PK) of meropenem given as a short (30-min) or prolonged (4-h) infusion to very-low-birth-weight (gestational age, <32 weeks; birth weight, <1,200 g) neonates to define the appropriate dosing regimen for a phase 3 efficacy study. Short (n = 9) or prolonged (n = 10) infusions of meropenem were given at a ...

Padari, Helgi; Metsvaht, Tuuli; Ko?rgvee, Lenne-triin; Germovsek, Eva; Ilmoja, Mari-liis; Kipper, Karin; Herodes, Koit; Standing, Joseph F.; Oselin, Kersti; Lutsar, Irja

2012-01-01

342

Changes in regional plasma extravasation in rats following endotoxin infusion  

International Nuclear Information System (INIS)

Regional differences in plasma extravasation during endotoxin shock in rats and a possible relationship with changes in regional blood flow were studied with radioactive isotopes (125I-HSA, 51Cr-labeled red blood cells, microspheres) in anesthetized rats (pentobarbital). Shock was induced by intravenous infusion of endotoxin (Eschericia coli; 10 mg X kg-1) for 60 min (starting at t = 0); at t = 120 min, the experiments were terminated. These rats (n = 8) were compared with time-matched control rats (n = 8). A third group (rats killed 7.5 min after injection of 125I-HSA, i.e., no extravasation; n = 8) served as baseline. The amount of plasma extravasated in 2 hr of endotoxin shock was significantly increased over control values in skin (by 67%), colon (88%), skeletal muscle (105%), stomach (230%), pancreas (300%), and diaphragm (1300%). Losses of 125I-HSA into intestinal lumen and peritoneal cavity had also increased over control values by 146 and 380%, respectively. Blood flow was compromised in most organs except heart and diaphragm. Extravasation when normalized for total plasma supply was correlated with total blood supply; the more the blood supply decreased, the higher the normalized extravasation. In the diaphragm, however, blood supply and plasma leakage increased together. Decreased blood supply and plasma extravasation may be related but they could also be simultaneously occurring independent phenomena with a common origin

1987-01-01

343

Changes in regional plasma extravasation in rats following endotoxin infusion  

Energy Technology Data Exchange (ETDEWEB)

Regional differences in plasma extravasation during endotoxin shock in rats and a possible relationship with changes in regional blood flow were studied with radioactive isotopes (/sup 125/I-HSA, 51Cr-labeled red blood cells, microspheres) in anesthetized rats (pentobarbital). Shock was induced by intravenous infusion of endotoxin (Eschericia coli; 10 mg X kg-1) for 60 min (starting at t = 0); at t = 120 min, the experiments were terminated. These rats (n = 8) were compared with time-matched control rats (n = 8). A third group (rats killed 7.5 min after injection of /sup 125/I-HSA, i.e., no extravasation; n = 8) served as baseline. The amount of plasma extravasated in 2 hr of endotoxin shock was significantly increased over control values in skin (by 67%), colon (88%), skeletal muscle (105%), stomach (230%), pancreas (300%), and diaphragm (1300%). Losses of /sup 125/I-HSA into intestinal lumen and peritoneal cavity had also increased over control values by 146 and 380%, respectively. Blood flow was compromised in most organs except heart and diaphragm. Extravasation when normalized for total plasma supply was correlated with total blood supply; the more the blood supply decreased, the higher the normalized extravasation. In the diaphragm, however, blood supply and plasma leakage increased together. Decreased blood supply and plasma extravasation may be related but they could also be simultaneously occurring independent phenomena with a common origin.

van Lambalgen, A.A.; van den Bos, G.C.; Thijs, L.G.

1987-07-01

344

Psychopathology and Continuous Subcutaneous Insulin Infusion in Type 1 Diabetes  

Science.gov (United States)

Aim. Continuous subcutaneous insulin infusion (CSII) is used as an option in patients with diabetes failing to multiple daily injections (MDI). Psychological factors may play a relevant role in the failure to attain therapeutic goals in patients on MDI. This could lead to an overrepresentation of psychopathology in patients treated with CSII. Methods. A consecutive series of 100 patients with type 1 diabetes was studied, collecting main clinical parameters and assessing psychopathology with the self-reported questionnaire Symptom Checklist 90-revised. Patients on CSII were then compared with those on MDI. Results. Of the 100 enrolled patients, 44 and 56 were on CSII and MDI, respectively. Among men, those on CSII were younger than those on MDI; conversely, no difference in age was observed in women. Women on CSII showed higher scores on most Symptom Checklist 90 subscales than those on MDI, whereas no differences were observed in men. Conclusion. Women with type 1 diabetes treated with CSII display higher levels of psychopathology than those on MDI. This is probably the consequence of the fact that patients selected for CSII are those failing to MDI. Higher levels of psychopathology could represent a limit for the attainment and maintenance of therapeutic goals with CSII.

Lamanna, Caterina; Dicembrini, Ilaria; Faravelli, Carlo; Calasso, Caterina; Mannucci, Edoardo

2013-01-01

345

Myasthenia gravis masquerading as dysphagia: unveiled by magnesium infusion.  

Science.gov (United States)

Myasthenia gravis (MG) is a neuromuscular disorder that typically affects the ocular, bulbar, neck, proximal limbs and respiratory muscles. Dysphagia can occasionally be the only presenting symptom leading to extensive but ultimately futile gastrointestinal workup. Delay in diagnosis and use of certain pharmacological agents in the interim can lead to a myasthenic crisis, which though diagnostic is life threatening. We document a case of dysphagia as the only symptom of myasthenia, diagnosed after a magnesium infusion precipitated myasthenic crisis. A 70-year-old Caucasian woman who had had progressive dysphagia for 2 years, for which multiple oesophageal dilations were performed. During a hosptalisation for further gastrointestinal workup, she went into myasthenic crisis (respiratory failure) after receiving magnesium replacement. She required ventilatory support and received five plasma exchange (PLEX) treatments after myasthenia was confirmed by the detection of high antiacetylcholine receptor antibody. Though her symptoms improved, she had a prolonged hospital stay (25 days) and required 18 days of mechanical ventilation. This underscores the morbidity associated with a delay in diagnosis of this condition. This case report suggests that neuromuscular causes should be considered early in elderly patients presenting with dysphagia. Timely diagnosis, initiation of management and avoidance of drugs that affect neuromuscular transmission may help reduce the morbidity and mortality associated with myasthenic crisis. PMID:24744075

Klair, Jagpal Singh; Rochlani, Yogita M; Meena, Nikhil K

2014-01-01

346

Hepatobiliary scintigraphy in patients receiving hepatic artery infusion chemotherapy  

International Nuclear Information System (INIS)

Two patients receiving hepatic artery infusion chemotherapy (HAIC) required cholecystectomy for both acute and chronic cholecystitis with cholelithiasis suggesting chemical cholecystitis. To evaluate the incidence of gall bladder dysfunction in patients receiving HAIC, the authors performed hepatobiliary scintigraphy using Tc-99m DISIDA or PIPIDA on eight patients receiving HAIC through an indwelling hepatic artery catheter and Infusaid (trademark) pump. In 7 of 8 patients, there was non-visualization of the gall bladder throughout the hepatobiliary study. In the eighth patient, the gall bladder visualized at 2 hr. One patient with non-visualization of the gall bladder at 4 hr developed acute symptoms requiring cholecystectomy which showed acute and chronic cholecystitis with cholethiasis. There was prominent sclerosis which was thought to be due to chemical cholecystitis as well as cholelithiasis. In all 10 patients, no evidence of cholecystitis had been observed during the surgical placement of the hepatic artery catheter and Infusaid pump. The hepatobiliary scintigraphic finding of gall bladder dysfunction in all eight patients studied is most likely due to chemical cholecystitis from HAIC. This series suggests that chemical cholecystitis is common during HAIC and can be identified by hepatobiliary scintigraphy. The authors consider elective cholecystectomy during the operative placement of the hepatic artery catheter and Infusaid pump

1984-06-05

347

Continuous dopaminergic stimulation achieved by duodenal levodopa infusion.  

Science.gov (United States)

Continuous dopaminergic stimulation is the ideal approach for the management of Parkinson's disease (PD); this goal can be partially reached with dopamine agonists, but the need for a therapeutic strategy providing a strong and constant dopaminergic stimulation also in the advanced phase of the disease remains unmet. The application of levodopa/carbidopa-gel suspension directly in the duodenum (Duodopa) allows a continuous delivery by a portable pump, resulting in smoother levodopa plasmatic concentrations, and consequently in a physiologic continuous receptor stimulation. Clinical studies have demonstrated that duodenal infusion was associated with significantly better outcome compared to conventional treatment regarding global functioning, ability to walk, "off" time and motor fluctuations. A retrospective analysis of the long-term clinical experience with Duodopa evidenced that daily dose of levodopa decreased by 5% during follow-up. The profile of pharmacological adverse events of Duodopa was similar to that observed with oral administration; dislocation of the intestinal tube to the stomach was the most common technical problem. PMID:19381770

Odin, Per; Wolters, Erik; Antonini, Angelo

2008-12-01

348

Radiation resistance of microorganisms on unsterilized infusion sets  

DEFF Research Database (Denmark)

Three different methods were used for detecting and isolating microorganisms with high radiation resistance from the microbial contamination on infusion sets prior to sterilization. By all three methods, microorganisms with a radiation resistance high enough to be a critical factor in a sterilization process (D-6 value greater-than-or-equal-to 30 kGy) were found with a frequency of approximately two colony forming units (cfu) per 100 product items, even though the product items in two of the series of analyses were irradiated with doses of 3-6 kGy. The frequency of occurrence of isolates with D-6 values greater-than-or-equal-to 30 kGy was 0.45 per 1000 cfu of the total aerobic count. Eight different isolates of microorganisms had D-6 values greater-than-or-equal-to 40 kGy when irradiated in dried laboratory preparation. All but one of these were classified according to morphologic criteria as Deinococcus, and all but one had nonlinear dose-response relationships in semilogarithmic presentation.

Christensen, E. Ahrensburg; Kristensen, H.

1991-01-01

349

Incidence and management of infusion reactions to infliximab in 186 italian patient’s with rheumatoid arthritis: the Padua experience  

Directory of Open Access Journals (Sweden)

Full Text Available Objective: We report the incidence and treatment of infusion reactions to infliximab, a chimeric monoclonal IgG1 antibody against tumor necrosis factor a, in a large cohort of patients with rheumatoid arthritis. Patients and methods: One hundred eighty six patients with rheumatoid arthritis treated with infliximab for a total of 216.6 patient years were retrospectively evaluated. Patients received 2160 infliximab infusions at the Division of Rheumatology at the University Hospital of Padua from May, 2000 to April, 2004. Specific treatment protocols for initial and subsequent acute infusion reactions were followed and the outcomes documented. Results: The overall incidence of infusion reactions to infliximab was 0.8% (19 out of 2160 of infusions, affecting 10.2% of patients (19 out of 186. Mild, moderate, or severe acute reactions occurred in 0.1% (3 of 2160, 0.6% (13 of 2160, and 0.04% (1 of 2160 of infliximab infusions, respectively. Delayed infusion reactions occurred in 0.09% (2 of 2160 of infusions. Use of specific treatment protocols resulted in rapid resolution of all acute reactions to infliximab. With a prophylaxis protocol, all patients who experienced an initial mild acute reaction were able to receive additional infusions. Conclusions: Using appropriate treatment protocols, infliximab infusion reactions were effectively treated and prevented in patients with mild acute reactions upon retreatment. In the case of moderate to severe infusion reactions, the risks and the benefits of the continuation of infliximab therapy need to be carefully considered.

S. Todesco

2011-09-01

350

Altered hepatic vasopressin and alpha 1-adrenergic receptors after chronic endotoxin infusion  

International Nuclear Information System (INIS)

Sepsis and septic shock are complicated by a number of hemodynamic and metabolic aberrations. These include catecholamine refractoriness and altered glucose metabolism. Recently, a nonshock rat model of continuous endotoxin infusion via an implanted osmotic pump was developed that reproduces some of the metabolic and cardiovascular findings of human sepsis. By using this model, we have found a decreased number of hepatic plasma membrane alpha 1-adrenergic and [Arg8]vasopressin receptors in rats continuously infused with endotoxin. There was a significant decrease in ["3H]prazosin (35 +/- 7%) and ["3H] [Arg8]vasopressin (43 +/- 8%) receptors after 30 h of continuous endotoxin infusion with no change in affinity. The ability of norepinephrine to form the high-affinity complex with alpha 1-adrenergic receptors was not altered after chronic endotoxin infusion. The results are consistent with the concept that alterations in receptor number might underlie certain of the metabolic consequences of chronic sepsis

1987-01-01

351

Hemodynamic effects of rapid and slow infusions of manganese chloride and gadolinium-DTPA in dogs  

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The acute hemodynamic effects of two paramagnetic contrast materials, manganese chloride and gadolinium-DTPA, were examined in dogs using ultrasonic dimension gauge crystals. Slow infusions (more than 15 minutes) of MnCl/sub 2/ or Gd-DTPA via an infusion pump had no significant hemodynamic effects. When given in just over 1 minute, Gd-DTPA produced elevated left ventricular (LV) end diastolic pressure and minor dilation of the ventricle and slowed diastolic filling. MnCl/sub 2/, given rapidly, reduced systemic vascular resistance, resulting in hypotension. With both agents, these side effects waned after 5-10 minutes. It is concluded that both Gd-DTPA and MnCl/sub 2/ can be given safely in 0.1-mm/kg doses when administered as a slow, continuous infusion. Slow, intravenous infusion of Gd-DTPA or MnCl/sub 2/ is likely to be tolerated well by even severely ill individuals.

Slutsky, R.A.; Peterson, T.; Strich, G.; Brown, J.J.

1985-03-01

352

In vitro study of the antioxidant and immunomodulatory activity of aqueous infusion of Bidens pilosa.  

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Bidens pilosa is an annual plant from tropical America with anti-inflammatory properties in hepatitis, laryngitis, headache and digestive disorders, among others. Its wide pharmacological applications can be attributed to its chemical composition, with inhibitory effects on pathogenic microorganisms and flavonoids, which show strong antioxidant capacities. We investigated the antioxidant activity of an aqueous infusion of Bidens pilosa by studying its protective effect on the hemolysis induced by an initiator of radicals such as 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH). The immunomodulatory activity of the infusion was tested using whole blood cells. Cytokine production increased in whole blood stimulated or not by lipopolysaccharides (LPSs). The infusion is also characterized by its capacity to protect erythrocytes from the phototoxic effect of chlorpromazine, which allows its use as a potential photoprotector. Finally, it did not show ocular irritation, as demonstrated by the effect on hemoglobin denaturation. This study supports the health benefits of the ingestion of the infusion. PMID:15234771

Abajo, Celia; Boffill, María Angeles; del Campo, Jaime; Alexandra Méndez, María; González, Yisel; Mitjans, Montserrat; Pilar Vinardell, María

2004-08-01

353

Intra-arterial Infusion of Leptin does not Affect Blood Pressure in Salt-loaded Rabbits  

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Full Text Available The aim of this research is to see the effect of intra-arterial infusion of leptin on blood pressure of salt loaded rabbits in vivo. Increased blood pressure was produced in rabbits by giving diets containing 8% sodium chloride for 5 weeks. Leptin in different concentrations was infused intra-arterially into rabbits fed on high salt diets and the response was compared in rabbits fed with low salt diets. High salt diets produced significant increase in blood pressure. In rabbits fed with low salt diet, leptin infused intra-arterially caused an increase in blood pressure while infusion of leptin into rabbits fed with high salt diets does not affect the blood pressure. In conclusion, salt loading to rabbits abolishes the effect of leptin on cardiovascular system. This may indicate that leptin effect on sympathetic activity is altered by high salt diets in these animals.

Mohammad Nidal Khabaz

2010-01-01

354

A technique of infusion of contrast material on CT enhancement study  

International Nuclear Information System (INIS)

We have studied the method of enhancement on a fast CT scanner of the third generation by changing the infusion time of contrast material, 3 min., 5 min. and 7 min., and by measuring the attenuation values of certain ROIs at 1 min., 3 min. and 5 min. after infusion. 60% meglumine iothalamate and 65% meglumine diatrizoate were compared in their enhancing effect and side effects. There was no difference in the enhancing effect between the two contrast materials, but 60% meglumine iothalamate had less side effect than the other. The longer the infusion time, the less the side effects, especially nausea and vomiting. We have come to the conclusion that 7 min. infusion of 100 ml of 60% meglumine iothalamate is the method of choice for contrast enhancement CT scan. (author)

1980-01-01

355

Hemodynamic effects of rapid and slow infusions of manganese chloride and gadolinium-DTPA in dogs  

International Nuclear Information System (INIS)

The acute hemodynamic effects of two paramagnetic contrast materials, manganese chloride and gadolinium-DTPA, were examined in dogs using ultrasonic dimension gauge crystals. Slow infusions (more than 15 minutes) of MnCl_2 or Gd-DTPA via an infusion pump had no significant hemodynamic effects. When given in just over 1 minute, Gd-DTPA produced elevated left ventricular (LV) end diastolic pressure and minor dilation of the ventricle and slowed diastolic filling. MnCl_2, given rapidly, reduced systemic vascular resistance, resulting in hypotension. With both agents, these side effects waned after 5-10 minutes. It is concluded that both Gd-DTPA and MnCl_2 can be given safely in 0.1-mm/kg doses when administered as a slow, continuous infusion. Slow, intravenous infusion of Gd-DTPA or MnCl_2 is likely to be tolerated well by even severely ill individuals

1985-03-01

356

Effect of the first infliximab infusion on sleep and alertness in patients with active rheumatoid arthritis  

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Material and methods: Evaluation of RA activity, sleepiness (Epworth scale and multiple sleep latency test), alertness (steer clear test), and sleep structure (polysomnography) were conducted before and after the first infusion of infliximab in six female patients with RA.

Zamarron, C.; Maceiras, F.; Mera, A.; Gomez-reino, J.

2004-01-01

357

A GOOD IDEA (INFUSING DATA INTO ENVIRONMEN TAL APPLICATIONS)-INVITED PRESENTATION  

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IDEA (Infusing satellite Data into Environmental Applications)is a partnership between researchers in the National Aeronautics and Space Administration (NASA), the United States Environmental Protection Agency (EP A), and the National Oceanic and Atmospheric Administration (NOAA)...

358

Preclinical Toxicology of Nsc 1895 Administered By 24-Hour Infusion in Dogs. Part II.  

Science.gov (United States)

NSC 1895, Guanazole, Triazole 3, 5-diamino-s, which shows strong antitumor activity has been studied for preclinical toxicological effects following weekly 24-hour infusions in young adult beagle dogs. At all dosage levels, clinical signs of toxicity were...

P. E. Palm M. S. Nick C. J. Kensler D. A. Cooney R. D. Davis

1969-01-01

359

Acute Cardiovascular Effects of Guanazole (NSC Number 1895) Following Continuous Intravenous Infusion to Anesthetized Beaglehounds.  

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Guanazole, in doses of 1750, 2500 and 5000 mg/kg was given by intravenous infusion over 60 minutes to normal, anesthetized beaglehounds instrumented for monitoring various cardiovascular parameters. Records were taken during two control periods 15 minutes...

R. L. Hamlin F. S. Pipers K. Nguyen P. Mihalko R. M. Folk

1977-01-01

360

CONTINUOUS INFUSION OF PYRIDOSTIGMINE IN THE MANAGEMENT OF MYASTHENIC CRISIS: A CASE REPORT  

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Myasthenia crisis is the most dangerous complication of myasthenia gravis. We report one case in which a continuous infusion of pyridostigmine resulted in successful management of myasthenia exacerbation in a 50 year old myasthenic female following thymectomy.

1998-01-01

 
 
 
 
361

CONTINUOUS INFUSION OF PYRIDOSTIGMINE IN THE MANAGEMENT OF MYASTHENIC CRISIS: A CASE REPORT  

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Full Text Available Myasthenia crisis is the most dangerous complication of myasthenia gravis. We report one case in which a continuous infusion of pyridostigmine resulted in successful management of myasthenia exacerbation in a 50 year old myasthenic female following thymectomy.

M. Mojiahedzadeh.

1998-08-01

362

Herbal infusions as a source of calcium, magnesium, iron, zinc and copper in human nutrition.  

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The study material consisted of five herbs: chamomile (flowers), mint (leaves), St John's wort (flowers and leaves), sage (leaves) and nettle (leaves), sourced from three producers. The calcium, magnesium, iron, zinc and copper contents were determined for both dried herb samples and prepared infusions, and the extraction rates were calculated. Mineral components were determined using atomic absorption spectrometry. Analysis showed that the contents of individual elements in herbs and infusions depended on the type of raw material, as well as on its origin. Moreover, it was found that iron penetrated the herbal infusions to the lowest degree (4.4-12.4%), while copper did so to the highest (26.7-50.7%). It is felt that in average consumption the herbal infusions are not important as calcium, magnesium, iron, zinc and copper sources in human nutrition. PMID:21916535

Suliburska, Joanna; Kaczmarek, Karolina

2012-03-01

363

Hemodynamic effects of mannitol infusion in patients with acute intracerebral hemorrhage  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english PURPOSE: To evaluate hemodynamic effects of mannitol infusion in patients with acute intracerebral hemorrhage. METHODS: Thirty patients with acute intracerebral hemorrhage were enrolled. Transcranial doppler was used to detect variables of bilateral middle cerebral arteria (MCA) including mean veloc [...] ity (Vm) and pulsitility index (PI) before and after125ml and 250ml mannitol infusion (0, 30, 60, 90, 120, 180, 240 min). RESULTS: When 125ml or 250ml mannitol was infused in patients with acute intracerebral hemorrhage, Vm of bilateral MCA elevated, and reached the top at 30min, and then decreased. PI decreased in the affected MCA (250ml) and in the unaffected MCA (125ml and 250ml). CONCLUSION: Mannitol infusion in patients with acute intracerebral hemorrhage can improve cerebral blood flow in bilateral hemispheres and decrease intracranial pressure in the hemorrhagic hemisphere (250ml) and in the nonhemorrhagic hemisphere (125ml and 250ml).

Hong, Ye; Yingying, Su.

364

Sterile Endophthalmitis in Vitrectomised Eyes due to Suspected Heat Resistant Endotoxins in the Infusion Fluid  

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Full Text Available Purpose: To report on to the possibility of development of severe postoperative sterile endophthalmitis due to heat-resistant bacterial endotoxins in commercially available infusion fluids Methods: A case study of 4 eyes that had previously undergone vitreoretinal surgery, which developed clinical endophthalmitis within 18 hours of surgery and two eyes that had vitreous surgery with intraocular gas and did not develop clinical endophthalmitis following intraocular surgery on three consecutive operative days Results: The vitreous samples were sterile, both for bacteria and fungi. The only common supply in all cases was a new batch of Ringer?s lactate infusion fluid. Though the Ringer?s lactate solutions in the same batch were also sterile, the infusion fluids contained abnormally high levels of bacterial endotoxins detected by gel clot method. Conclusion: Commercially available infusion fluid may be sterile, yet contain endotoxins from killed bacteria. This could cause postoperative sterile endophthalmitis.

Patnaik Bijayananda

2004-01-01

365

Comparison of the attractiveness of organic infusions to the standard CDC gravid mosquito trap.  

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Field experiments were conducted in southeastern Texas in 2008 to compare the attractiveness of selected gravid-trap infusions to ovipositing female mosquitoes. Comparisons were made among the following infusions: Bermuda grass, oak leaves, acacia leaves, rabbit chow (alfalfa pellets) and green algae. Experiments were conducted at 6 trap locations in Fort Sam Houston military reservation in San Antonio, Texas. Four (Bermuda grass, acacia leaves, oak leaves, and algae) of the 5 infusions were effective in collecting Culex quinquefasciatus, Cx nigripalpus, and Cx erraticus. However, Bermuda grass attracted the greatest numbers of the mosquito species. Aedes albopictus female mosquitoes were collected in moderate numbers during this study; however the infusions were not determined to be significantly different from one another in their attractiveness for this species. PMID:20084742

McPhatter, Lee P; Olsen, Cara H; Debboun, Mustapha

2009-01-01

366

Determination of mineral and trace elements in some medicinal herbs and their infusions consumed in Turkey.  

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Fourteen mineral and trace elements (Al, Ba, Ca, Cd, Co, Cr, Cu, Fe, Mg, Mn, Ni, Pb, Sr and Zn) were determined in the herbs and their infusions consumed for medical purposes in Turkey such as chamomile (Matricaria chammomile L.), fennel (Foeniculum vulgare), linden (Tilia vulgaris), nettle (Urtica dioical), rosehip (Fr.Rosa caninae), sage (Salvia officinalis) and senna tea (Cassia anqustifolia). Microwave digestion procedure was applied under optimized conditions for dissolution of medicinal herbs. Element concentrations in the medicinal herbs and their infusions were determined by FAAS and ICP-AES. The accuracy and precision were verified against a GBW 07605 Poplar leaves and Tea certified reference material. The mineral and trace element content of medicinal herbs and their infusions showed a wide variability. However, distribution of the elements in the infusions is not high and it is nil especially for Cd, Co, Cr and Pb. PMID:15907975

Ba?gel, S; Erdemo?lu, S B

2006-04-15

367

Efficacy of Synthetic Insecticide and Botanical Infusions Against Onion Thrips in Balochistan, Pakistan-I  

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Full Text Available A synthetic insecticide (Monocrotophos 40WSL and three botanical infusions (Datura alba Seed Extract Infusion, SEI; Calotropis procera Latex Infusion, LI and Citrullus colocynthus Fruit Extract Infusion, FEI were tried against onion thrips on broadcasted onion variety “Chlitan 89” in Quetta, Pakistan. All tested insecticides caused mortality of onion thrips at various degrees of significance over untreated control. C. procera LI, proved it self the best among the tested botanical insecticides and provided 42.67 % control after Monocrotophos that caused 76.24 % mortality of onion thrips. D. alba SEI and C. colocynthus FEI showed minimal control (17.23 and 6.77 % respectively of the said pest than other tested insecticides but the results encourage the idea of pollution free methods of pest control. The C. procera LI can be used as good as any other botanical insecticide in Integrated Pest Management (IPM of onion thrips.

Muhammad Faheem Malik

2003-01-01

368

Hemodynamic effects of mannitol infusion in patients with acute intracerebral hemorrhage  

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Full Text Available PURPOSE: To evaluate hemodynamic effects of mannitol infusion in patients with acute intracerebral hemorrhage. METHODS: Thirty patients with acute intracerebral hemorrhage were enrolled. Transcranial doppler was used to detect variables of bilateral middle cerebral arteria (MCA including mean velocity (Vm and pulsitility index (PI before and after125ml and 250ml mannitol infusion (0, 30, 60, 90, 120, 180, 240 min. RESULTS: When 125ml or 250ml mannitol was infused in patients with acute intracerebral hemorrhage, Vm of bilateral MCA elevated, and reached the top at 30min, and then decreased. PI decreased in the affected MCA (250ml and in the unaffected MCA (125ml and 250ml. CONCLUSION: Mannitol infusion in patients with acute intracerebral hemorrhage can improve cerebral blood flow in bilateral hemispheres and decrease intracranial pressure in the hemorrhagic hemisphere (250ml and in the nonhemorrhagic hemisphere (125ml and 250ml.

Hong Ye

2013-02-01

369

Decoction, infusion and hydroalcoholic extract of Origanum vulgare L.: different performances regarding bioactivity and phenolic compounds.  

Science.gov (United States)

Bioactivity of oregano methanolic extracts and essential oils is well known. Nonetheless, reports using aqueous extracts are scarce, mainly decoction or infusion preparations used for therapeutic applications. Herein, the antioxidant and antibacterial activities, and phenolic compounds of the infusion, decoction and hydroalcoholic extract of oregano were evaluated and compared. The antioxidant activity is related with phenolic compounds, mostly flavonoids, since decoction presented the highest concentration of flavonoids and total phenolic compounds, followed by infusion and hydroalcoholic extract. The samples were effective against gram-negative and gram-positive bacteria. It is important to address that the hydroalcoholic extract showed the highest efficacy against Escherichia coli. This study demonstrates that the decoction could be used for antioxidant purposes, while the hydroalcoholic extract could be incorporated in formulations for antimicrobial features. Moreover, the use of infusion/decoction can avoid the toxic effects showed by oregano essential oil, widely reported for its antioxidant and antimicrobial properties. PMID:24731316

Martins, Natália; Barros, Lillian; Santos-Buelga, Celestino; Henriques, Mariana; Silva, Sónia; Ferreira, Isabel C F R

2014-09-01

370

Utilities associated with subcutaneous injections and intravenous infusions for treatment of patients with bone metastases  

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Full Text Available Louis S Matza,1 Ze Cong,2 Karen Chung,2 Alison Stopeck,3 Katia Tonkin,4 Janet Brown,5 Ada Braun,2 Kate Van Brunt,6 Kelly McDaniel1 1Outcomes Research, United BioSource Corporation, Bethesda, MD, USA; 2Amgen, Inc, Thousand Oaks, CA, USA; 3Department of Medicine, University of Arizona, Tucson, AZ, USA; 4Department of Oncology, University of Alberta, Edmonton, Alberta, Canada; 5Leeds Institute of Molecular Medicine, St James University Hospital, Leeds, UK; 6formerly with Outcomes Research, United BioSource Corporation, Bethesda, MD, USA Introduction: Although cost-utility models are often used to estimate the value of treatments for metastatic cancer, limited information is available on the utility of common treatment modalities. Bisphosphonate treatment for bone metastases is frequently administered via intravenous infusion, while a newer treatment is administered as a subcutaneous injection. This study estimated the impact of these treatment modalities on health state preference. Methods: Participants from the UK general population completed time trade-off interviews to assess the utility of health state vignettes. Respondents first rated a health state representing cancer with bone metastases. Subsequent health states added descriptions of treatment modalities (ie, injection or infusion to this basic health state. The two treatment modalities were presented with and without chemotherapy, and infusion characteristics were varied by duration (30 minutes or 2 hours and renal monitoring. Results: A total of 121 participants completed the interviews (52.1% female, 76.9% white. Cancer with bone metastases had a mean utility of 0.40 on a standard utility scale (1 = full health; 0 = dead. The injection, 30-minute infusion, and 2-hour infusion had mean disutilities of ?0.004, ?0.02, and ?0.04, respectively. The mean disutility of the 30-minute infusion was greater with renal monitoring than without. Chemotherapy was associated with substantial disutility (?0.17. When added to health states with chemotherapy, the mean disutilities of injection, 30-minute infusion, and 2-hour infusion were ?0.02, ?0.03, and ?0.04, respectively. The disutility associated with injection was significantly lower than the disutility of the 30-minute and 2-hour infusions (P < 0.05, regardless of chemotherapy status. Conclusion: Respondents perceived an inconvenience with each type of treatment modality, but injections were preferred over infusions. The resulting utilities may be used in cost-utility models examining the value of treatments for the prevention of skeletal-related events in patients with bone metastases. Keywords: skeletal-related event, infusion, injection

Matza LS

2013-08-01

371

Use of a variable tracer infusion method to determine glucose turnover in humans  

International Nuclear Information System (INIS)

The single-compartment pool fraction model, when used with the hyperinsulinemic glucose clamp technique to measure rates of glucose turnover, sometimes underestimates true rates of glucose appearance (Ra) resulting in negative values for hepatic glucose output (HGO). We focused our attention on isotope discrimination and model error as possible explanations for this underestimation. We found no difference in [3-3H] glucose specific activity in samples obtained simultaneously from the femoral artery and vein (2,400 +/- 455 vs. 2,454 +/- 522 dpm/mg) in 6 men during a hyperinsulinemic euglycemic clamp study where insulin was infused at 40 mU.m-2.min-1 for 3 h; therefore, isotope discrimination did not occur. We compared the ability of a constant (0.6 microCi/min) vs. variable tracer infusion method (tracer added to the glucose infusate) to measure non-steady-state Ra during hyperinsulinemic clamp studies. Plasma specific activity fell during the constant tracer infusion studies but did not change from base line during the variable tracer infusion studies. By maintaining a constant plasma specific activity the variable tracer infusion method eliminates uncertainty about changes in glucose pool size. This overcame modeling error and more accurately measures non-steady-state Ra (P less than 0.001 by analysis of variance vs. constant infusion method). In conclusion, underestimation of Ra determined isotopically during hyperinsulinemic clamp studies is largely due to modeling error that can be overcome by use of the variable tracer infusion method. This method allows more accurate determination of Ra and HGO under non-steady-state conditions

1990-01-01

372

Plasma Calcium, Inorganic Phosphate and Magnesium During Hypocalcaemia Induced by a Standardized EDTA Infusion in Cows  

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The intravenous Na2EDTA infusion technique allows effective specific chelation of circulating Ca2+ leading to a progressive hypocalcaemia. Methods previously used were not described in detail and results obtained by monitoring total and free ionic calcium were not comparable due to differences in sampling and analysis. This paper describes a standardized EDTA infusion technique that allowed comparison of the response of calcium, phosphorus and magnesium between 2...

Lsb, Mellau; Rj, Jørgensen; Jmd, Enemark

2001-01-01

373

Tolerability, safety and efficacy of Iloprost infusion without peristaltic pump in systemic sclerosis  

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Objective. To evaluate safety, tolerability and efficacy on Raynaud’s phenomenon (Rp) of iloprost infusion without peristaltic pump in patients with systemic sclerosis (SSc). Patients and methods. The inclusion criteria were diagnosis of SSc, age between 18 and 65 years, presence of Rp, and absence of any controindication to the use of iloprost. The treatment was carried out in a day hospital setting and consisted first of 5 consecutive days of iloprost infusion (from an initial dose of 1.0...

Arreghini, M.; Prudente, P.; Maglione, W.; Arnoldi, C.; Tosi, S.; Marchesoni, A.

2011-01-01

374

Prophylactic fibrinogen infusion reduces bleeding after coronary artery bypass surgery. A prospective randomised pilot study.  

Science.gov (United States)

It has been suggested that preoperative fibrinogen plasma concentration is independently associated to postoperative blood loss after cardiac surgery. Theoretically, prophylactic infusion of fibrinogen concentrate may thus reduce postoperative bleeding, but this has not previously been investigated. Twenty elective coronary artery bypass graft (CABG) patients with preoperative plasma fibrinogen levels <3.8 g/l were included in a prospective randomised pilot study. Patients were randomised to receive an infusion of 2 g fibrinogen concentrate (FIB group) or no infusion before surgery (control group). Primary endpoint was safety with clinical adverse events and graft occlusion assessed by multi-slice computed tomography. Predefined secondary endpoints were postoperative blood loss, blood transfusions, haemoglobin levels 24 hours (h) after surgery, and global haemostasis assessed with thromboelastometry, 2 and 24 hours after surgery. Infusion of 2 g fibrinogen concentrate increased plasma levels of fibrinogen by 0.6 +/- 0.2 g/l. There were no clinically detectable adverse events of fibrinogen infusion. Computed tomography revealed one subclinical vein graft occlusion in the FIB group. Fibrinogen concentrate infusion reduced postoperative blood loss by 32% (565 +/- 150 vs. 830 +/- 268 ml/12 h, p=0.010). Haemoglobin concentration was significantly higher 24 h after surgery in the FIB group (110 +/- 12 vs. 98 +/- 8 g/l, p=0.018). Prophylactic fibrinogen concentrate infusion did not influence global postoperative haemostasis as assessed by thromboelastometry. In conclusion, in this pilot study preoperative fibrinogen concentrate infusion reduced bleeding after CABG without evidence of postoperative hypercoagulability. Larger studies are necessary to ensure safety and confirm efficacy of prophylactic fibrinogen treatment in cardiac surgery. PMID:19572078

Karlsson, Martin; Ternström, Lisa; Hyllner, Monica; Baghaei, Fariba; Flinck, Agneta; Skrtic, Stanko; Jeppsson, Anders

2009-07-01

375

Plasma infusions in thrombotic thrombocytopenic purpura complicating systemic lupus erythematosus—a successful outcome  

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A severe form of acute thrombotic thrombocytopenic purpura (TTP) developed in a patient with systemic lupus erythematosus (SLE). Infusions of large amounts of fresh frozen plasma (FFP) were added to steroid therapy and resulted in a rapid improvement and remission. Further episodes of thrombocytopenia and abdominal pains during a two-year follow-up were successfully treated with plasma alone and this indicates the important role of FFP infusions in the recovery of this patient.

Finkelstein, R.; Markel, A.; Carter, A.; Brook, J. G.

1982-01-01

376

ANTIMICROBIAL AND ANTIOXIDANT COMPOUNDS FROM THE INFUSION AND METHANOLIC EXTRACT OF Baccharis incarum (WEDD.) PERKINS  

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In the traditional medicine of the South American highlands, the infusion and decoction of aerial parts of “tola”, Baccharis incarum (Wedd.) Perkins (Asteraceae) is orally taken as an antiseptic, antipyretic and digestive or externally applied to relieve pain and infammation. A plant infusion and methanolic (MeOH) extract of the aerial parts were compared for main constituents by HPLC-MS as well as assessed for antimicrobial and free radical scavenging activities. Assay-guided fractionati...

IRIS CATIANA ZAMPINI; MARÍA INÉS ISLA; GUILLERMO SCHMEDA-HIRSCHMANN

2009-01-01

377

Assessment of hepatic blood flow in healthy subjects by continuous infusion of indocyanine green.  

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1. The applicability of a continuous infusion of indocyanine green (ICG) to detect changes in apparent hepatic blood flow (HBF) was investigated in six healthy subjects. 2. High-performance liquid chromatography was used to measure ICG concentrations, and the effect of intravenous propranolol (10 mg in 10 min) on HBF was investigated. 3. During 150 min infusions of ICG (1.0 mg min-1) steady-state was reached within about 30 min and thereafter the plasma dye concentration remained essentially ...

Soons, P. A.; Boer, A.; Cohen, A. F.; Breimer, D. D.

1991-01-01

378

Albumin infusion in humans does not model exercise induced hypervolaemia after 24 hours  

Science.gov (United States)

We rapidly infused 234 +/- 3 mL of 5% human serum albumin in eight men while measuring haematocrit, haemoglobin concentration, plasma volume (PV), albumin concentration, total protein concentration, osmolality, sodium concentration, renin activity, aldosterone concentration, and atrial natriuretic peptide concentration to test the hypotheses that plasma volume expansion and plasma albumin content expansion will not persist for 24 h. Plasma volume and albumin content were expanded for the first 6 h after infusion (44.3 +/- 1.9-47.2 +/- 2.0 mL kg-1 and 1.9 +/- 0.1-2.1 +/- 0.1 g kg-1 at pre-infusion and 1 h, respectively, P < 0.05), but by 24 h plasma volume and albumin content decreased significantly from 1 h post-infusion and were not different from pre-infusion (44.8 +/- 1.9 mL kg-1 and 1.9 +/- 0.1 g kg-1, respectively). Plasma aldosterone concentration showed a significant effect of time over the 24 h after infusion (P < 0.05), and showed a trend to decrease at 2 h after infusion (167.6 +/- 32.5(-1) 06.2 +/- 13.4 pg mL-1, P = 0.07). These data demonstrate that a 6.8% expansion of plasma volume and 10.5% expansion of plasma albumin content by infusion does not remain in the vascular space for 24 h and suggest a redistribution occurs between the intravascular space and interstitial fluid space.

Haskell, A.; Gillen, C. M.; Mack, G. W.; Nadel, E. R.

1998-01-01

379

Intratumoral infusion of fluid: estimation of hydraulic conductivity and implications for the delivery of therapeutic agents.  

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We have developed a new technique to measure in vivo tumour tissue fluid transport parameters (hydraulic conductivity and compliance) that influence the systemic and intratumoral delivery of therapeutic agents. An infusion needle approximating a point source was constructed to produce a radially symmetrical fluid source in the centre of human tumours in immunodeficient mice. At constant flow, the pressure gradient generated in the tumour by the infusion of fluid (Evans blue-albumin in saline)...

Boucher, Y.; Brekken, C.; Netti, P. A.; Baxter, L. T.; Jain, R. K.

1998-01-01

380

Use of a variable tracer infusion method to determine glucose turnover in humans.  

Science.gov (United States)

The single-compartment pool fraction model, when used with the hyperinsulinemic glucose clamp technique to measure rates of glucose turnover, sometimes underestimates true rates of glucose appearance (Ra) resulting in negative values for hepatic glucose output (HGO). We focused our attention on isotope discrimination and model error as possible explanations for this underestimation. We found no difference in [3-3H] glucose specific activity in samples obtained simultaneously from the femoral artery and vein (2,400 +/- 455 vs. 2,454 +/- 522 dpm/mg) in 6 men during a hyperinsulinemic euglycemic clamp study where insulin was infused at 40 mU.m-2.min-1 for 3 h; therefore, isotope discrimination did not occur. We compared the ability of a constant (0.6 microCi/min) vs. variable tracer infusion method (tracer added to the glucose infusate) to measure non-steady-state Ra during hyperinsulinemic clamp studies. Plasma specific activity fell during the constant tracer infusion studies but did not change from base line during the variable tracer infusion studies. By maintaining a constant plasma specific activity the variable tracer infusion method eliminates uncertainty about changes in glucose pool size. This overcame modeling error and more accurately measures non-steady-state Ra (P less than 0.001 by analysis of variance vs. constant infusion method). In conclusion, underestimation of Ra determined isotopically during hyperinsulinemic clamp studies is largely due to modeling error that can be overcome by use of the variable tracer infusion method. This method allows more accurate determination of Ra and HGO under non-steady-state conditions. PMID:2405697

Molina, J M; Baron, A D; Edelman, S V; Brechtel, G; Wallace, P; Olefsky, J M

1990-01-01

 
 
 
 
381

Recombinant human tripeptidyl peptidase-1 infusion to the monkey CNS: Safety, pharmacokinetics, and distribution.  

Science.gov (United States)

CLN2 disease is caused by deficiency in tripeptidyl peptidase-1 (TPP1), leading to neurodegeneration and death. The safety, pharmacokinetics (PK), and CNS distribution of recombinant human TPP1 (rhTPP1) were characterized following a single intracerebroventricular (ICV) or intrathecal-lumbar (IT-L) infusion to cynomolgus monkeys. Animals received 0, 5, 14, or 20mg rhTPP1, ICV, or 14mg IT-L, in artificial cerebrospinal fluid (aCSF) vehicle. Plasma and CSF were collected for PK analysis. Necropsies occurred at 3, 7, and 14days post-infusion. CNS tissues were sampled for rhTPP1 distribution. TPP1 infusion was well tolerated and without effect on clinical observations or ECG. A mild increase in CSF white blood cells (WBCs) was detected transiently after ICV infusion. Isolated histological changes related to catheter placement and infusion were observed in ICV treated animals, including vehicle controls. The CSF and plasma exposure profiles were equivalent between animals that received an ICV or IT-L infusion. TPP1 levels peaked at the end of infusion, at which point the enzyme was present in plasma at 0.3% to 0.5% of CSF levels. TPP1 was detected in brain tissues with half-lives of 3-14days. CNS distribution between ICV and IT-L administration was similar, although ICV resulted in distribution to deep brain structures including the thalamus, midbrain, and striatum. Direct CNS infusion of rhTPP1 was well tolerated with no drug related safety findings. The favorable nonclinical profile of ICV rhTPP1 supports the treatment of CLN2 by direct administration to the CNS. PMID:24642058

Vuillemenot, Brian R; Kennedy, Derek; Reed, Randall P; Boyd, Robert B; Butt, Mark T; Musson, Donald G; Keve, Steve; Cahayag, Rhea; Tsuruda, Laurie S; O'Neill, Charles A

2014-05-15

382

Antimutagenic Activity and Radical Scavenging Activity of Water Infusions and Phenolics from Ligustrum Plants Leaves  

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Water infusions of Ligustrum delavayanum and Ligustrum vulgare leaves and eight phenolics isolated therefrom have been assayed in vitro on ofloxacin-induced genotoxicity in the unicellular flagellate Euglena gracilis. The tested compounds luteolin, quercetin, luteolin-7-glucoside, luteolin-7-rutinoside, quercetin-3-rutinoside, apigenin-7-rutinoside, tyrosol and esculetin inhibited the mutagenic activity of ofloxacin (43 µM) in E. gracilis. Water infusions from leaves of L. delavayanum...

Milan Nagy; Lívia Križková; Pavel Mučaji; Zuzana Kontšeková; František Šeršeň; Juraj Krajčovič

2009-01-01

383

Labetalol infusion for refractory hypertension causing severe hypotension and bradycardia: an issue of patient safety  

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Abstract Incremental doses of intravenous labetalol are safe and effective and, at times, such therapy may need to be augmented by a continuous infusion of labetalol to control severe hypertension. Continuous infusions of labetalol may exceed the recommended maximum daily dose of 300 mg on occasion. We report a case in which hypertension occurring after an abdominal aortic aneurysm repair, initially responsive to intermittent intravenous beta-blockade, became resistant to this thera...

Fahed Samir; Grum Daniel F; Papadimos Thomas J

2008-01-01

384

Infusion of nonmyeloablative bone marrow alleviates acute rejection reaction in liver allotransplantation*  

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Objective: To study the effect and implication of nonmyeloablative donor specific bone marrow (DSBM) infusion on the immunoreaction of liver allotransplantation. Methods: Orthotopic liver transplantation model was used in this study. Groups were set as follows: Group I, syngeneic control (Wistar-to-Wistar); Group II, acute rejection (SD-to-Wistar); Group III, acute rejection treated with cyclosporine A (CsA) by intramuscular injection (SD-to-Wistar+CsA); Group IV, bone marrow infusion at 7 d ...

Xie, Hai-yang; Huang, Dong-sheng; Jia, Chang-ku; Zheng, Shu-sen

2005-01-01

385

Determination of lead, cadmium and arsenic in infusion tea cultivated in north of Iran  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Abstract Tea is one of the most common drinks in all over the world. Rapid urbanization and industrialization in recent decades has increased heavy metals in tea and other foods. In this research, heavy metal contents such as lead (Pb), cadmium (Cd) and arsenic (As) were determined in 105 black tea samples cultivated in Guilan and Mazandaran Provinces in north of Iran and their tea infusions. The amount of heavy metals in black tea infusions were analyzed using Inductively Coupled P...

Shekoohiyan Sakine; Ghoochani Mahboobeh; Mohagheghian Azita; Mahvi Amir Hossein; Yunesian Masoud; Nazmara Shahrokh

2012-01-01

386

Lack of antibacterial activity after intravenous hydrogen peroxide infusion in experimental Escherichia coli sepsis.  

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The intravenous administration of hydrogen peroxide has been reported to benefit patients with pneumonia and to reduce Plasmodium parasitemia in experimentally infected mice. We assessed the antibacterial activity of intravenously infused hydrogen peroxide against hydrogen peroxide-susceptible Escherichia coli (MBC of hydrogen peroxide, 0.23 mM) in experimentally infected rabbits. No decrease in the level of bacteremia was detected at the maximum intravenous infusion rate of hydrogen peroxide...

Shenep, J. L.; Stokes, D. C.; Hughes, W. T.

1985-01-01

387

Use of a variable tracer infusion method to determine glucose turnover in humans  

Energy Technology Data Exchange (ETDEWEB)

The single-compartment pool fraction model, when used with the hyperinsulinemic glucose clamp technique to measure rates of glucose turnover, sometimes underestimates true rates of glucose appearance (Ra) resulting in negative values for hepatic glucose output (HGO). We focused our attention on isotope discrimination and model error as possible explanations for this underestimation. We found no difference in (3-3H) glucose specific activity in samples obtained simultaneously from the femoral artery and vein (2,400 +/- 455 vs. 2,454 +/- 522 dpm/mg) in 6 men during a hyperinsulinemic euglycemic clamp study where insulin was infused at 40 mU.m-2.min-1 for 3 h; therefore, isotope discrimination did not occur. We compared the ability of a constant (0.6 microCi/min) vs. variable tracer infusion method (tracer added to the glucose infusate) to measure non-steady-state Ra during hyperinsulinemic clamp studies. Plasma specific activity fell during the constant tracer infusion studies but did not change from base line during the variable tracer infusion studies. By maintaining a constant plasma specific activity the variable tracer infusion method eliminates uncertainty about changes in glucose pool size. This overcame modeling error and more accurately measures non-steady-state Ra (P less than 0.001 by analysis of variance vs. constant infusion method). In conclusion, underestimation of Ra determined isotopically during hyperinsulinemic clamp studies is largely due to modeling error that can be overcome by use of the variable tracer infusion method. This method allows more accurate determination of Ra and HGO under non-steady-state conditions.

Molina, J.M.; Baron, A.D.; Edelman, S.V.; Brechtel, G.; Wallace, P.; Olefsky, J.M. (Univ. of California School of Medicine, La Jolla (USA))

1990-01-01

388

Numerical analysis and forecast of the in-seam water infusion effectiveness  

Energy Technology Data Exchange (ETDEWEB)

Based on the principles of numerical theory I, a mathematical model for forecasting the parameters and the effectiveness of water infusion (the moisture increment) is built. It has provided a computation method for the engineers on site to predict the infusion effectiveness and adjust any parameters if necessary. The method is simple and practical. Field application showed that it has satisfied the requirement of the engineering project. 3 refs., 7 tabs.

Hai, G.; Qin, S.; Li, Z.; Seng, H. [Fuxin Mining Institute (China)

1994-10-01

389

The infusion of fauna of water cleaning installations working with mechanical method  

International Nuclear Information System (INIS)

According to our investigations 77 kinds of infusions are determined in the watercleaning installations, working with mechanical method. In the given article the description of watercleaning installations, spreading of infusions on taxons in water purifying basins, their changes according to the seasons, the number of dynamics on biotops, the comparison of siliofauna of cleaning installations on their role in the cleaning of water are analyzed

2008-01-01

390

Tumor and liver drug uptake following hepatic artery and portal vein infusion  

Energy Technology Data Exchange (ETDEWEB)

Anatomic dye injection studies of the blood supply of colorectal hepatic metastases suggest that tumors are supplied predominantly by the hepatic artery. Using /sup 13/N amino acids with dynamic gamma camera imaging in patients with colorectal hepatic metastases, it has been shown that hepatic artery infusion results in a significantly greater nutrient delivery to tumor compared with portal vein infusion. However, direct measurements of drug levels in tumor following hepatic artery and portal vein infusion in humans have not previously been reported. Patients with metastatic colorectal cancer confined to the liver received fluorodeoxyuridine (FUdR) through the hepatic artery or through the portal vein. All patients had previously failed systemic chemotherapy. Five patients with hepatic artery catheters were matched (by age, serum lactic dehydrogenase levels, percent hepatic replacement, and tumor size) with five patients with portal vein catheters. At operation, /sub 3/H-FUdR (1 microCi/kg) and /sup 99m/Tc-macroaggregated albumin (MAA) (6 mCi) were injected into the hepatic artery or portal vein. Liver and tumor biopsies were obtained two and five minutes later. /sub 3/H and /sup 99m/Tc were measured per gram tissue by scintillation and gamma counting. The mean liver levels following hepatic artery infusion (23.9 +/- 11.4 nmol/g) and portal vein infusion (18.4 +/- 14.5 nmol/g) did not differ. However, the mean tumor FUdR level following hepatic artery infusion was 12.4 +/- 12.2 nmol/g, compared with a mean tumor FUdR level following portal vein infusion of 0.8 +/- 0.7 nmol/g (P less than .01). This low level of tumor drug uptake after portal vein infusion of FUdR predicts minimal tumor response to treatment via this route. Thus, regional chemotherapy for established colorectal hepatic metastases should be administered through the hepatic artery.

Sigurdson, E.R.; Ridge, J.A.; Kemeny, N.; Daly, J.M.

1987-11-01

391

Sivelestat Attenuates Myocardial Reperfusion Injury during Brief Low Flow Postischemic Infusion  

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The neutrophil elastase inhibitor sivelestat (ONO-5046) possesses unknown mechanisms of cardioprotection when infused following global ischemia, even in the absence of neutrophils. Since myocardial ischemia-reperfusion injury is strongly associated with endothelial dysfunction and reactive oxygen species (ROS) generation during reperfusion, we have tested the hypothesis that infusion of sivelestat during postischemic low flow would preserve endothelial and contractile function and reduce infa...

2013-01-01

392

Hepatic arterial infusion chemotherapy in hepatocellular carcinoma with portal vein tumor thrombosis  

Digital Repository Infrastructure Vision for European Research (DRIVER)

AIM: To evaluate the prognostic factors and efficacy of hepatic arterial infusion chemotherapy in hepatocellular carcinoma with portal vein tumor thrombosis. METHODS: Fifty hepatocellular carcinoma (HCC) patients with portal vein tumor thrombosis (PVTT) were treated using hepatic arterial infusion chemotherapy (HAIC) via a subcutaneously implanted port. The epirubicin-cisplatin-5-fluorouracil (ECF) chemotherapeutic regimen consisted of 35 mg/m2 epirubicin on day 1, 60 mg/m2 cisplatin for 2 h ...

2013-01-01

393

Testicular morphology of adult wistar rats treated with Rudgea viburnoides (Cham.) Benth. leaf infusion  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The present study was carried out to investigate the effects of Rudgea viburnoides infusion on the body biometry and testicular morphometry and stereology of adult Wistar rats. Two groups received the infusion daily at the concentration of 3 or 6 mg/mL for 40 days. The control group received only water. Neither the biometrical parameters nor the tubular diameter and the height of the seminiferous epithelium showed any significant alterations in the treated animals. Leydig cells stereology did...

Juliana Castro Monteiro; Sérgio Luis Pinto da Matta; Fabrícia de Souza Predes; Tarcízio Antônio Rego de Paula

2012-01-01

394

UJI KHASIAT ANTIDIARE INFUS DAUN JATI BELANDA (GUAZUMA ulmifolia LAMK.) PADA TIKUS PUTIH  

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Salah satu pemakaian empirik daun jati-belanda adalah sebagai obat mencret atau diare. Diketahui di dalam daun jati-belanda terkandung zat yang berperan sebagai astrigen yaitu menciutkan lapisan permukaan usus, sehingga mengurangi kepekaan sekresi yang dapat menekan peristaltik usus. Untuk mengetahui efek antidiare infus daun jati-belanda, telah dilakukan percobaan uji khasiat antidiare infus daun jati-belanda (Guazuma ulmifolia Lamk.) menggunakan model tik...

2012-01-01

395

Subcutaneous narcotic infusions for cancer pain: treatment outcome and guidelines for use.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

OBJECTIVE: To provide guidelines for the institution and maintenance of a continuous subcutaneous narcotic infusion program for cancer patients with chronic pain through an analysis of the narcotic requirements and treatment outcomes of patients who underwent such therapy and a comparison of the costs of two commonly used infusion systems. DESIGN: Retrospective study. SETTING: Tertiary care facilities and patients' homes. PATIENTS: Of 481 patients seen in consultation for cancer pain between ...

Moulin, D. E.; Johnson, N. G.; Murray-parsons, N.; Geoghegan, M. F.; Goodwin, V. A.; Chester, M. A.

1992-01-01

396

Determination of lead, cadmium and arsenic in infusion tea cultivated in north of Iran  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Tea is one of the most common drinks in all over the world. Rapid urbanization and industrialization in recent decades has increased heavy metals in tea and other foods. In this research, heavy metal contents such as lead (Pb), cadmium (Cd) and arsenic (As) were determined in 105 black tea samples cultivated in Guilan and Mazandaran Provinces in north of Iran and their tea infusions. The amount of heavy metals in black tea infusions were analyzed using Inductively Coupled Plasma Atomic Emissi...

2012-01-01

397

Determination of Lead, Cadmium and Arsenic in Infusion Tea Cultivated in North of Iran  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Tea is one of the most common drinks in all over the world. Rapid urbanization and industrialization in recent decades has increased heavy metals in tea and other foods. In this research, heavy metal contents such as lead (Pb), cadmium (Cd) and arsenic (As) were determined in 105 black tea samples cultivated in Guilan and Mazandaran Provinces in north of Iran and their tea infusions. The amount of heavy metals in black tea infusions were analyzedusing Inductively Coupled Plasma Atomic Emissio...

2012-01-01

398

Duodenal levodopa infusion for advanced Parkinson's disease: 12-month treatment outcome  

Digital Repository Infrastructure Vision for European Research (DRIVER)

We assessed prospectively clinical and quality of life changes in 9 patients with Parkinson's disease (PD; HY > or = 3) with severe motor fluctuations and dyskinesia who started continuous daily levodopa duodenal infusion through percutaneous endoscopic gastrostomy. Seven patients completed the follow-up period. Duration of 'off' periods and time with disabling dyskinesia shortened significantly in all patients (P < 0.01). Total daily dose of levodopa infused did not differ from baseline equi...

2007-01-01

399

Analysis of response to enteral infusion of levodopa in patients with Parkinson's disease  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Objective: We present a new evaluation of levodopa plasma concentrations and clinical effects during duodenal infusion of a levodopa/carbidopa gel (Duodopa ) in 12 patients with advanced Parkinson s disease (PD), from a study reported previously (Nyholm et al, Clin Neuropharmacol 2003; 26(3): 156-163). One objective was to investigate in what state of PD we can see the greatest benefits with infusion compared with corresponding oral treatment (Sinemet CR). Another objective was to identify f...

2004-01-01

400

Patient-Perceived Retrospective Outcome of Duodenal Levodopa Infusion in Advanced Parkinson’s Disease  

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Patients with advanced Parkinson’s disease (PD) are dependent on adequate dopaminergic therapy to treat motor and non-motor fluctuations. Continuous duodenal levodopa/carbidopa infusion is effective in relieving such complications, but patient-perceived outcome has not been thoroughly investigated so far. The present study retrospectively examined the patient-perceived frequency, as well as the discomfort, from both motor and non-motor symptoms before and after levodopa infusion initia...

2010-01-01

 
 
 
 
401

Duodenal levodopa infusion improves quality of life in advanced Parkinson's disease  

Digital Repository Infrastructure Vision for European Research (DRIVER)

BACKGROUND: A significant percentage of patients with Parkinson's disease (PD) continue to experience motor fluctuations and dyskinesias despite the association of dopamine agonists and levodopa with COMT or MAO-B inhibitors. The use of apomorphine infusion is limited by compliance while deep brain stimulation is feasible only for a small number of patients mostly because of age constraints. OBJECTIVE: To assess prospectively the effectiveness of duodenal levodopa infusion on quality of life ...

2008-01-01

402

Selecting deep brain stimulation or infusion therapies in advanced Parkinson's disease : an evidence-based review  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Motor complications in Parkinson’s disease (PD) result from the short half-life and irregular plasma fluctuations of oral levodopa. When strategies of providing more continuous dopaminergic stimulation by adjusting oral medication fail, patients may be candidates for one of three device-aided therapies: deep brain stimulation (DBS), continuous subcutaneous apomorphine infusion, or continuous duodenal/jejunal levodopa/carbidopa pump infusion (DLI). These therapies differ in their invasivenes...

2013-01-01

403

Any way goes:identifying value constellations for service infusion in SMEs  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Manufacturing firms have always delivered services, by supplying spare parts, installing equipment, training employees, or performing maintenance. In competitive markets though, firms seek new ways to differentiate their business, including an increased focus on service, often referred to as service infusion. Of the studies that seek to understand this phenomenon, most focus on large multinational firms; little is known about service infusion in small and medium-sized enterprises (SMEs). This...

2013-01-01

404

Any way goes : Identifying value constellations for service infusion in SMEs  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Manufacturing firms have always delivered services, by supplying spare parts, installing equipment, training employees, or performing maintenance. In competitive markets though, firms seek new ways to differentiate their business, including an increased focus on service, often referred to as service infusion. Of the studies that seek to understand this phenomenon, most focus on large multinational firms; little is known about service infusion in small and medium-sized enterprises (SMEs). This...

2013-01-01

405

Selection of vasodilator therapy for severe Raynaud's phenomenon by sequential arterial infusion.  

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Two young adults with impending gangrene due to persistent Raynaud's vasospasm were studied by sequential intra-arterial (IA) infusion of three vasodilatory drugs while arterial pressure and plethysmographic digital pulse volume were continuously monitored. The results of the IA infusion accurately predicted relief from vasospastic symptoms by oral drugs of the same class. This method may be useful in selecting the most effective vasodilator for patients with severe vasospasm.

Russell, I. J.; Walsh, R. A.

1985-01-01

406

A comparison of continuous infusion of vecuronium and atracurium in midline and paramedian laparotomies.  

Directory of Open Access Journals (Sweden)

Full Text Available This was a study to compare continuous intravenous infusion of atracurium with continuous intravenous infusion of vecuronium for intraoperative muscle relaxation in 62 ASA I / II patients. Scheduled for laparotomies and pelvic surgeries under general anaesthesia. They were randomly allocated in two groups to receive either vecuronium infusion of 50 microg/kg/hour following a bolus dose of 0.1 microg/kg, or atracurium infusion of 400 microg/kg/hour following a bolus dose of 0.5 microg/kg. The mean infusion dose of atracurium was 478 +/- 44.11 microg/kg/hour and that of vecuronium was 63.2 +/- 74 microg/kg/hour for adequate muscle relaxation. The depth of neuromuscular blockade was monitored by using peripheral nerve stimulator so that only one twitch of train of four was present, resistance to ventilation, surgical relaxation and haemodynamic changes. Vecuronium infusions produced more haemodynamic stability than atracurium infusions. Vecuronium produced lesser change in systolic blood pressure (mean change of 3. 46 +/- 3.33% from baseline values as compared to atracurium (mean change of 5.81 +/- 3.73% from baseline values ( p < 0.01 which was statistically significant. The difference in mean pulse rate change from baseline value in the atracurium group (4.78 +/- 2.745% was less than that in the vecuronium group (5.99 +/- 2.67%, which was not statistically significant. Spontaneous recovery was faster with vecuronium (540.94 +/- 76.46 seconds as compared to atracurium (596. 33 +/- 72.48 seconds. 84.4% of patients who received vecuronium fell within good to very good category of muscle relaxation as compared to 63.3% in atracurium group. There were no cost benefits when either agents were used in infusion form.

Chaudhari L

1999-01-01