WorldWideScience
 
 
1

Study Protocol. ECSSIT – Elective Caesarean Section Syntocinon® Infusion Trial. A multi-centre randomised controlled trial of oxytocin (Syntocinon®) 5 IU bolus and placebo infusion versus oxytocin 5 IU bolus and 40 IU infusion for the control of blood loss at elective caesarean section  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Caesarean section is one of the most commonly performed major operations in women throughout the world. Rates are escalating, with studies from the United States of America, the United Kingdom, China and the Republic of Ireland reporting rates between 20% and 25%. Operative morbidity includes haemorrhage, anaemia, blood transfusion and in severe cases, maternal death. The value of routine oxytocics in the third stage of vaginal birth has been well established and it has been assumed that these benefits apply to caesarean delivery as well. A slow bolus dose of oxytocin is recommended following delivery of the baby at caesarean section. Some clinicians use an additional infusion of oxytocin for a further period following the procedure. Intravenous oxytocin has a very short half-life (4–10 minutes) therefore the potential advantage of an oxytocin infusion is that it maintains uterine contractility throughout the surgical procedure and immediate postpartum period, when most primary haemorrhages occur. The few trials to date addressing the optimal approach to preventing haemorrhage at caesarean section have been under-powered to evaluate clinically important outcomes. There has been no trial to date comparing the use of an intravenous slow bolus of oxytocin versus an oxytocin bolus and infusion. Methods and design A multi-centre randomised controlled trial is proposed. The study will take place in five large maternity units in Ireland with collaboration between academics and clinicians in the disciplines of obstetrics and anaesthetics. It will involve 2000 women undergoing elective caesarean section after 36 weeks gestation. The main outcome measure will be major haemorrhage (blood loss >1000 ml). A study involving 2000 women will have 80% power to detect a 36% relative change in the risk of major haemorrhage with two-sided 5% alpha. Discussion It is both important and timely that we evaluate the optimal approach to the management of the third stage at elective caesarean section. Safe operative delivery is now a priority and a reality for many pregnant women. Obstetricians, obstetric anaesthetists, midwives and pregnant women need high quality evidence on which to base management approaches. The overall aim is to reduce maternal haemorrhagic morbidity and its attendant risks at elective caesarean section. Trial registration number: ISRCTN17813715

Murphy Deirdre J; Carey Michael; Montgomery Alan A; Sheehan Sharon R

2009-01-01

2

Study protocol. ECSSIT - Elective Caesarean Section Syntocinon Infusion Trial. A multi-centre randomised controlled trial of oxytocin (Syntocinon) 5 IU bolus and placebo infusion versus oxytocin 5 IU bolus and 40 IU infusion for the control of blood loss at elective caesarean section.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Caesarean section is one of the most commonly performed major operations in women throughout the world. Rates are escalating, with studies from the United States of America, the United Kingdom, China and the Republic of Ireland reporting rates between 20% and 25%. Operative morbidity inc...

MURPHY, DEIRDRE

3

Study Protocol. ECSSIT – Elective Caesarean Section Syntocinon® Infusion Trial. A multi-centre randomised controlled trial of oxytocin (Syntocinon®) 5 IU bolus and placebo infusion versus oxytocin 5 IU bolus and 40 IU infusion for the control of blood loss at elective caesarean section  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Abstract Background Caesarean section is one of the most commonly performed major operations in women throughout the world. Rates are escalating, with studies from the United States of America, the United Kingdom, China and the Republic of Ireland reporting rates between 20% and 25%...

Murphy Deirdre J; Carey Michael; Montgomery Alan A; Sheehan Sharon R

4

Current use of intraosseous infusion in Danish emergency departments: a cross-sectional study  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Abstract Background Intraosseous infusion (IOI) is recommended when intravenous access cannot be readily established in both pediatric and adult resuscitation. We evaluated the current use of IOI in Danish emergency departments (EDs). Methods An online questionnaire wa...

Molin Rune; Hallas Peter; Brabrand Mikkel; Schmidt Thomas

5

Current use of intraosseous infusion in Danish emergency departments: a cross-sectional study  

DEFF Research Database (Denmark)

Intraosseous infusion (IOI) is recommended when intravenous access cannot be readily established in both pediatric and adult resuscitation. We evaluated the current use of IOI in Danish emergency departments (EDs).

Molin, Rune; Hallas, Peter

2010-01-01

6

Evaluation of the Effect of Intravenous Lidocaein Infusion on Postoperative Analgesia after Cesarean Section under Spinal Anesthesia  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction & Objective: Many surgical patients still experience moderate to severe pain after surgery despite efforts to administer new drugs and techniques. Postoperative analgesia clearly enhances patient’s satisfaction and facilitates earlier mobilization and rehabilitation. lidocaein has been introduced as part of post operative pain management and clinical studies revealed analgesic actions in patients with chronic neuropathic pain. Our goal in this study was to determine the effect of intravenous lidocaein on post operative pain of women under-going cesarean section under spinal anesthesia. Materials & Methods: In this double blinded clinical trial study, 72 patients candidate for Ce-sarean section under spinal anesthesia were randomly selected and divided in two groups. In the case group, infusion of1.5 mg/kg lidocaein and in the control group infusion of the same volume normal saline started 15 minutes before the beginning of operation. After spinal anes-thesia with definite technique in both groups, infusion of 1.5 mg/kg/h lidocaein in case group and the same volume normal saline in the control group was administered and continued till 0.5 hour after finishing the operation. Data including systolic and diastolic blood pressure, heart rate, analgesic score according VAS and using of analgesic drugs were recorded during 24 hours after the operation. Results: Pain intensity according to VAS score in the time 2,6,12 hours post operation were significantly lower in the case group ( P2= 0.05, P6 = 0.01, P12= 0.05) .Analgesic consumption in form of suppository & IV,24 hours after surgery, was significantly lower in the case group.(P=0.001). Conclusion: Lidocaein infusion can decrease pain intensity & analgesic consumption after ce-sarean section under spinal anesthesia. (Sci J Hamadan Univ Med Sci 2013; 20 (1):9-14)

M. H. Bakhshaei; M. Davoudi; A. Amini

2013-01-01

7

Current use of intraosseous infusion in Danish emergency departments : a cross-sectional study  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Udgivelsesdato: 2010 , BACKGROUND: Intraosseous infusion (IOI) is recommended when intravenous access cannot be readily established in both pediatric and adult resuscitation. We evaluated the current use of IOI in Danish emergency departments (EDs). METHODS: An online questionnaire was e-mailed to the ...

Molin, Rune; Hallas, Peter; Brabrand, Mikkel; Schmidt, Thomas Andersen

8

The usefulness of thin section rapid infusion CT for detection of cerebral aneurysm  

Energy Technology Data Exchange (ETDEWEB)

With 2 mm thick CT scanning during the rapid infusion of contrast material(TICT), cerebral aneurysms arising from the circle of Willis and adjacent vessels can be directly visualized. Twenty five patients who had cerebral aneurysm confirmed by surgery were examined with TICT and digital subtraction angiography. The authors examined TICT prospectively to assess the detection rate of the cerebral aneurysms and to evaluation the clinical usefulness of TICT. The detection rates of aneurysms by TICT and digital subtraction angiography were 68% and 84%, respectively. TICT is a rapid, safe and reliable method in the evaluation of patients with suspected cerebral aneurysm, permitting direct visualization of the aneurysm.

Kim, Jong Min; Kim, So Sun; Huh, Jin Do [Kosin Medical College, Pusan (Korea, Republic of)

1993-11-15

9

Current use of intraosseous infusion in Danish emergency departments: a cross-sectional study.  

UK PubMed Central (United Kingdom)

BACKGROUND: Intraosseous infusion (IOI) is recommended when intravenous access cannot be readily established in both pediatric and adult resuscitation. We evaluated the current use of IOI in Danish emergency departments (EDs). METHODS: An online questionnaire was e-mailed to the Heads of Department of the twenty EDs currently established in Denmark. The questionnaire focused on the use of IOI in the EDs and included questions on frequency of use, training, equipment and attitudes towards IOI. RESULTS: We received a total of 19 responses (response rate of 95%). Of the responding 19 Danish EDs 74% (n = 14) reported having intraosseous devices available. The median number of IOI procedures performed in these departments over the preceding 12 months was 5.0 (range: 0-45). In 47% (n = 9) of the departments, prior training sessions in the use of intraosseous devices had not been provided, and 42% (n = 8) did not have local guidelines on IOI. The indication for IOI use was often not clearly defined and only 11% (n = 2) consistently used IOI on relevant indication. This is surprising as 95% (n = 18) of responders were aware that IOI can be utilized in both pediatric and adult resuscitation. CONCLUSIONS: The study shows considerable variations in IOI usage in Danish EDs despite the fact that IOI devices were available in the majority of EDs. In addition, in many EDs there were no local guidelines on IOI and no training in the procedure. We recommend more extensive training of medical staff in IOI techniques in Danish EDs.

Molin R; Hallas P; Brabrand M; Schmidt TA

2010-01-01

10

Current use of intraosseous infusion in Danish emergency departments: a cross-sectional study  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Intraosseous infusion (IOI) is recommended when intravenous access cannot be readily established in both pediatric and adult resuscitation. We evaluated the current use of IOI in Danish emergency departments (EDs). Methods An online questionnaire was e-mailed to the Heads of Department of the twenty EDs currently established in Denmark. The questionnaire focused on the use of IOI in the EDs and included questions on frequency of use, training, equipment and attitudes towards IOI. Results We received a total of 19 responses (response rate of 95%). Of the responding 19 Danish EDs 74% (n = 14) reported having intraosseous devices available. The median number of IOI procedures performed in these departments over the preceding 12 months was 5.0 (range: 0-45). In 47% (n = 9) of the departments, prior training sessions in the use of intraosseous devices had not been provided, and 42% (n = 8) did not have local guidelines on IOI. The indication for IOI use was often not clearly defined and only 11% (n = 2) consistently used IOI on relevant indication. This is surprising as 95% (n = 18) of responders were aware that IOI can be utilized in both pediatric and adult resuscitation. Conclusions The study shows considerable variations in IOI usage in Danish EDs despite the fact that IOI devices were available in the majority of EDs. In addition, in many EDs there were no local guidelines on IOI and no training in the procedure. We recommend more extensive training of medical staff in IOI techniques in Danish EDs.

Molin Rune; Hallas Peter; Brabrand Mikkel; Schmidt Thomas

2010-01-01

11

[The influence of warmed infusion during C-section on the mother and child--a pilot randomised prospective study].  

UK PubMed Central (United Kingdom)

AIM OF THE STUDY: To evaluate the influence of warmed infusions on the mothers and newborns well-being after C-section. DESIGN: Prospective randomized study. SETTING: Dept. of Anaesthesiology, Resuscitation and Intensive Care Medicine, Dept. of Obstetrics and Gynaecology, Faculty of Medicine and Dentistry Palacký University and University Hospital Olomouc. METHODS: Prospective randomized study including 29 pregnant women between 38th and 42nd week of pregnancy, that were indicated to elective caesarian section (SC) and from all of which the fetal distress was excluded. The women were randomized into four groups according to the temperature of applied infusion solution - colloids and afterwards crystalloids (pre-heated and non pre-heated), and according to the type of anaesthesia (general or SAB). These values were monitored in perioperative period: body temperature, differences of hemoglobin and hematocrit levels, tremor and pain level after the operation. In newborns the acid-base balance parameters and Apgar score were monitored. RESULTS: The study is still going on, however up to now some of the results suggest that usage of pre-heated infusion solutions is effective both for mother and child in increasing of their comfort in the perioperative period. In the group of actively heated mothers we have noticed: lower perioperative blood loss - differences in haemoglobin levels were 8 g/l compared to 15 g/l in the group of non heated mothers. The umbilical cord blood of the newborns whose mothers were not actively heated and were operated in subarachnoid anaesthesia had the lowest pO2 (0.9 kPa). The lowest level of umbilical cord blood lactate was noticed in the group of newborns whose mothers underwent the surgery under general anaesthesia and were actively heated. CONCLUSION: Up to now results suggest that the heating of mothers during the SC lowers the loss of body temperature, blood loss, and perception of pain by the mother. In combination with general anaesthesia it increases pO2 and lowers the levels of lactate in umbilical arteria in the newborns.

Kirchnerová M; Mrozek Z; Oborná I; Kantor L

2013-06-01

12

[Biochemical markers of cardiac damage increased after carbetocin infusion during cesarean section].  

UK PubMed Central (United Kingdom)

BACKGROUND: carbetocin, a potentially cardio toxic drug is used by intravenous bolus for uterine bleeding prevention during cesarean section. The aim was to assess the cardiac effects of carbetocin in patients undergoing cesarean sections. METHODS: a pretest-postest design study was carried out on 74 women (23 ± 5.3 years, ASA I-II classification, no history of pregnant induced-hypertension) who underwent elective or emergency cesarean section. At surgical room entry (baseline), and after administration of carbetocin (infunded 100 ?g along 30 minutes) during the anesthesic-surgical follow up, vital signs and EKG were registered; and CK, CK MB, and troponin I blood levels were measured. Wilcoxon's rank test was used. RESULTS: significant changes were found on CK (30 vs. 58), CK MB (4.0 vs. 5.9), troponin I (0.01 vs. 0.03), blood sistolic pressure (110 vs. 100), blood diastolic pressure (70 vs. 60) and heart rate (76 vs. 90); all of them: p < 0.001. However, no patient showed heart ischemia signs during EKG monitoring. CONCLUSIONS: an increase on biochemical indicators of myocardiac damage blood levels was observed after the administration of a carbetocin bolus in patients underwent cesarean section.

Gamboa-López Gde J; Bolado-García PB; Alvarez-Nemegyei J

2012-09-01

13

[Ephedrine vs. phenylephrine by intravenous bolus and continuous infusion to prevent hypotension secondary to spinal anesthesia during cesarean section: a randomized comparative trial].  

UK PubMed Central (United Kingdom)

OBJECTIVE: Subarachnoid spinal anesthesia for cesarean section is associated with a high incidence of hypotension, which can require the use of vasoconstrictors. The aim of this trial was to compare ephedrine to phenylephrine for the prevention of secondary hypotension and to assess the adverse effects on both mother and newborn. MATERIAL AND METHODS: Eighty patients undergoing elective or emergency cesarean section, in the absence of uterine activity or fetal risk, were randomized to receive prophylaxis with ephedrine or phenylephrine immediately after the spinal block. Patients in the ephedrine group received an intravenous bolus of 0.1 mg/kg plus continuous infusion at a rate of 0.5 mg/kg/h; patients in the phenylephrine group received an intravenous bolus of 1.5 microg/kg plus a continuous infusion at 1.5 microg/kg/min. Infusion was maintained until umbilical cord clamping. We recorded maternal blood pressure, heart rate, nausea and vomiting, dizziness, bradycardia, hypotension, hypertension, fetal Apgar index, and umbilical cord blood parameters (pH, PCO2, and HCO3). RESULTS: The overall incidence of hypotension was 11.2%, with no significant between-group differences (ephedrine group, 11.4%; phenylephrine group, 11.1%). The incidences of hypertension and bradycardia were higher in the phenylephrine group (27.8% and 2.3%, respectively) than in the ephedrine group (25% and 0%, respectively). Umbilical cord blood parameters and Apgar scores were similar. After suspension of continuous infusion, an episode of hypotension was detected in 22.5% of the patients (72.2% of these patients were in the phenylephrine group and 27.8% were in the ephedrine group). CONCLUSIONS: At the doses of ephedrine and phenylephrine administered in this trial, the ability of these drugs to prevent hypotension during cesarean section proved to be similar. Higher incidences of adverse events (hypertension and bradycardia) were observed in the phenylephrine group. No differences were observed in neonatal effects.

Alday Muñoz E; Palacio Abizanda F; De Diego Pdel R; Gilsanz Rodríguez F

2011-08-01

14

Carbetocin versus sublingual misoprostol plus oxytocin infusion for prevention of postpartum hemorrhage at cesarean section in patients with risk factors: a randomized, open trail study.  

UK PubMed Central (United Kingdom)

OBJECTIVES: To compare combined sublingual misoprostol plus oxytocin infusion with intravenous carbetocin for prevention of postpartum hemorrhage (PPH) in patients with risk factors during cesarean section (CS). METHODS: In this randomized study, 380 patients were randomly allocated to receive either combined 400 ?g sublingual misoprostol before surgery plus 20 IU oxytocin after delivery of baby (n = 190) or intravenous 100 ?g carbetocin (n = 190). The main outcome measure was requirement of additional pharmacological uterotonic. Secondary outcomes were the difference in preoperative and postoperative hemoglobin, estimated blood loss, incidence of blood transfusion and adverse effects. RESULTS: 16.3 % of women who received sublingual misoprostol plus oxytocin infusion required additional uterotonic versus 13.7 % of women who received intravenous carbetocin with no significant difference (p = 0.27). No significant difference between treatment groups in preoperative and postoperative hemoglobin level change, estimated blood loss, incidence of blood transfusion was observed. Shivering and fever were significantly higher with misoprostol plus oxytocin (p = <0.001 and <0.001, respectively). CONCLUSION: Both sublingual misoprostol plus oxytocin infusion and intravenous carbetocin are similarly effective for the prevention of PPH in patients with risk factors during CS.

Elgafor El Sharkwy IA

2013-05-01

15

Case report: hyponatremia and generalized convulsion after intravenous oxytocin infusion  

Directory of Open Access Journals (Sweden)

Full Text Available Most patients with drug-induced hyponatraemia are asymptomatic and the diagnosis is made incidentally following routine blood tests. Mild cases may be managed either by stopping the drug or by careful observation if the drug is considered essential. Severe hyponatremia (serum sodium levels less than 120 mmol/l) is associated with increased morbidity and mortality (confusion, convulsions, coma, congestive heart failure e.g.). We present a case of severe water intoxication with convulsion and prolonged coma, following the use of a high dose syntocinon infusion. A 22-year-old female who has intrauterine anencephalic fetus was refered to our hospital. Intravenous oxytocin was used to induce first-trimester abortion, eight hours later generalized tonic-clonic seizures occured and coma followed. Hyponatremia was found as the cause and treated by intravenous infusion of hypertonic 3% NaCl. The patient recovered and no seizure observed on follow-up. The central nervous system manifestations of acute hyponatremia may be related to cerebral edema. Drugs administration and electrolyte disturbances should be remembered as causes of coma and seizure in obstetric patients.

Ufuk Emre; Gülay Kad?o?lu; Aysun Ünal; H. Tu?rul Atasoy

2009-01-01

16

TOMATO SWEET INFUSION PROCESS  

UK PubMed Central (United Kingdom)

A tomato sweet infusion process involves heating sliced tomato sections in a bath of high fructose corn syrup, water, citric acid and ascorbic acid. The tomato sections in the bath are subjected to cycles of negative pressure and atmospheric pressure and then spread on a drying tray. The tomato sections are dehydrated to a moisture content of between twelve and twenty percent, preferably between fourteen percent and eighteen percent.

CORONA CESAR; MCGILL TIM; BENECH ROBERT

17

Infusion alarm  

UK PubMed Central (United Kingdom)

The invention discloses an infusion alarm. The alarm comprises a shell 1, an alarm device 2 and an infusion liquid metering electric contact device 3, wherein the alarm device 2 comprises a circuit control chip 21, a battery 22, a touch switch 23 and a buzzer 25 the infusion liquid metering electric contact device 3 comprises a spring tube 31, a spring 32, a sliding conductive bar 33 and an infusion bottle rod 34 the spring tube 31 is arranged in shell 1 an open slot 35 is arranged on the wall of the spring tube 31 the spring 32 is arranged in the spring tube 31 the sliding conductive bar 33 is connected to the upper end or the lower end of the spring 32 the two ends of the sliding conductive bar 33 are positioned in the open slot 35 the upper end of the infusion bottle rod 34 is fixedly connected with the sliding conductive bar 33, while the lower end is connected with a hook 36 and the sliding conductive bar 33 is connected with the circuit control chip 21. The alarm has the advantage of realizing the automatic alarming when no infusion liquid is left and timely treatment is needed so as to avoid the trouble and fatigue of a person special in charge of the infusion process.

CHAOSHENG XUE

18

Infusion sleeve  

UK PubMed Central (United Kingdom)

An infusion sleeve having a two-piece body. The first piece is conical in shape and is attached to the handpiece by conventional methods. The distal end of the first piece contains a series of annular grooves. The second piece is tubular in shape and contains an annular rim or lip on the proximal end that interlocks within the annular grooves on the first piece.

INJEV VALENTINE P

19

INFUSION SLEEVE  

UK PubMed Central (United Kingdom)

An infusion sleeve having a two-piece body. The first piece is conical in shape and is attached to the handpiece by conventional methods. The distal end of the first piece contains a series of annular grooves. The second piece is tubular in shape and contains an annular rim or lip on the proximal end that interlocks within the annular grooves on the first piece.

INJEV Valentine P.

20

Intraosseous infusion.  

UK PubMed Central (United Kingdom)

Establishing vascular access is vital in the resuscitation of critically-ill children and adults. Intraosseous infusion (IOI) is a viable route for providing vascular access when traditional intravenous methods cannot be accomplished. IOI is relatively easy to perform and is a standard recommended intervention for the resuscitation of both adults and children. The authors review the history, anatomy, technique, and clinical application of IOI. They also highlight the use of IOI in the prehospital setting.

LaRocco BG; Wang HE

2003-04-01

 
 
 
 
21

INFUSION PUMPS  

UK PubMed Central (United Kingdom)

Ambulatory infusion pumps, pump assemblies, cartridges, baseplates, cannulas, insertion tools, and related components as well as combinations thereof and related methods. An exemplary medicament cartridge may comprise: a barrel defining at least a substantial portion of a medicament reservoir that has a total filled volume and a plunger movable with respect to the barrel to controllably dispense out of the reservoir an amount of medicament of 0.1% or less of the total filled volume of the reservoir and with a single-dose precision ofbetter than plus or minus 20% and the precision is obtained within a dispensing period of less than eight hours.

SMITH ROGER E; CAUSEY JAMES; GIBSON SCOTT R; HE TOM XIAOHAI; FOGARTY THOMAS G; RING LAWRENCE SCOTT; LOFTIN SCOTT M

22

Critical parameters in drug delivery by intravenous infusion.  

UK PubMed Central (United Kingdom)

INTRODUCTION: Intravenous infusion is commonly used to deliver medications and fluids to patients. The duration of an infusion is short (hours) in the operating room where intravenous agents are infused to anesthetize patients and to manage circulation. Critically ill patients often receive infusions for days. Infusion technology has become increasingly sophisticated and complex. The technical advances broaden the clinical application of intravenous infusion methodology and provide safety features. AREAS COVERED: This article provides an historical overview of intravenous infusion and discusses components of infusion systems. A section describes configuration of components to meet clinical needs. The article describes physical properties of infusion systems, emphasizing how critical parameters of resistance to flow, infusion pump performance and interactions between fluid flows and the dead volume influence medication and fluid delivery. The authors emphasize the use of infusions in the intensive care and operating room environments, although the general principles apply to other clinical settings. EXPERT OPINION: Intravenous infusion systems contribute significantly to clinical care, but in a deceptively simple way. Several critical parameters combine to influence the performance of an infusion system, with a number of pitfalls potentially confounding utility of the technology. Safe and effective clinical application of intravenous infusion technology depends on an appreciation of this complexity which impacts the performance of infusion systems.

Peterfreund RA; Philip JH

2013-08-01

23

Telescopic pressurizing infusion set  

UK PubMed Central (United Kingdom)

The utility model belongs to a medical instrument, and particularly relates to a telescopic pressurizing infusion set, which comprises an infusion support and an air inlet pipe. The infusion support comprises a motor, a telescopic rod and a control panel which are connected sequentially, and an elastic air bag is arranged in the air inlet pipe. Therefore, the height of the infusion support can be adjusted by controlling the telescopic rod with electric energy, the control panel arranged on the infusion support facilitates operation of a patient, and a certain pressure can be kept when the height of the infusion support is adjusted, so that blood backflow is prevented.

GUOMEI SHEN

24

Infusion pump integration.  

UK PubMed Central (United Kingdom)

A very small but growing number of hospitals have begun integrating their infusion pumps with their information systems and patient records. integrating your pumps can dramatically reduce infusion-related medication errors. But there are a number of significant barriers. Find out how the three main approaches to integration work, and learn some best practices for tackling the challenges.

2013-07-01

25

Intraosseous Infusion Device.  

Science.gov (United States)

A device for infusion or aspiration that includes a base and at least one needle positioned within the base, where the base includes one or more locators for positioning the infusion device in relation to one or more predetermined anatomical features. A d...

D. Nedder J. F. Stokes M. J. Turieo R. P. Maloney R. W. Etheredge

2005-01-01

26

Infusion pump integration.  

Science.gov (United States)

A very small but growing number of hospitals have begun integrating their infusion pumps with their information systems and patient records. integrating your pumps can dramatically reduce infusion-related medication errors. But there are a number of significant barriers. Find out how the three main approaches to integration work, and learn some best practices for tackling the challenges. PMID:23967467

2013-07-01

27

CINA: a software to Compose INfusion sheets for i.v. Anesthetic drugs.  

UK PubMed Central (United Kingdom)

CINA is a software which uses LOTUS 1-2-3 commands and macros and it runs on an IBM PC. It contains an extensive database of three sections. Section 1 includes a list of several models of commercialized infusion devices. Section 2 presents the available IV packagings for a list of IV drugs. Section 3 contains the record of IV standard infusion regimens for each drug. Any other new infusion device, drug, or standard infusion regimen can be added or modified. The software verifies the compatibility of the prescribed infusion device according to the available drug packaging contained in the database. Moreover, it converts the infusion steps into the flow-rate units of the selected infusion device according to the patient's weight and the chosen drug concentration. Finally, the software allows the storage of all the information on a disk file or outputting on a printer.

Barvais L; Cantraine F; Coussaert E; d'Hollander A

1991-01-01

28

Home infusion 101.  

UK PubMed Central (United Kingdom)

This article is a brief compilation of some of the information a compounding pharmacist should consider if they are interested in entering the home infusion therapy business. Home infusion therapy is a prevalent and growing business, wrought out of necessity, convenience, and effectiveness. A coumpounding pharmacist can assist in making the patient's transition from hospital to home infusion care go smoother and with minimum amount of stress. A treatment strategy that continues the healing process by taking place in a patient's home, keeps healthier patients from potentially contracting illnesses in a hospital setting. By working with a team made up of the physician, nurse, pharmacist, dietitian, and the patient, decision making for the appropriate care becomes an easier task.

Williams LA

2011-01-01

29

MEDICATION INFUSION SET  

UK PubMed Central (United Kingdom)

An infusion set is provided for use in delivering fluid through a cannula, which is housed on a cannula housing, to a selected subcutaneous infusion site on a patient. The fluid is generally a medication, e.g., insulin. The cannula is in fluid communication with a fluid passageway surrounded by a projection on the cannula housing that includes one or more rail-like extensions acting as guides. A connector connects the cannula housing to a fluid delivery system, e.g., an infusion pump. The connector includes a needle, one or more guide arms that slide over the rail-like extensions to guide the needle into the self-sealing septum, and one or more locking arms, with barbs at the end, to connect with corresponding recesses in the cannula housing. An introducer having one or more similar guide arms and locking arms, and a longer needle, may be used to insert the cannula into the patient.

MAULE SUSIE E; MOBERG SHELDON B; HOLECEK ARIN N; GRIFFIN CHRISTOPHER G; KAVAZOV JULIAN D; KOVELMAN PAUL H

30

INFUSION SET SAFETY MANAGER  

UK PubMed Central (United Kingdom)

PURPOSE: An infusion set safety manager is provided to prevent a hose from being twisted, adjust the temperature of a medicine agent and handle an injection needle with safety after injection in a process of injecting a fluid into the body of a patient through the infusion set. CONSTITUTION: A shelf(3) is mounted on the center part of a main body(1) to be vertically movable and an intermediate connector connecting a lot of hoses(9b) is placeable on the shelf(3). A cylinder(4) is assembled on one side of the main body(1) and a water cylinder(2) is mounted on the other side for winding and fixing hoses(9b) thereto. An infusion bar(10) is inserted between a groove of the main body(1) and a plate(6a) and fixed by a clamping screw(6).

NAM YOUNG HEE

31

Back infusion stand  

UK PubMed Central (United Kingdom)

The utility model discloses a back infusion stand, which comprises a back plate, a back rod with retractable function, a suspender, a picking type arm sling, and a waist belt with a nylon fastener, wherein the back rod is fixed between the upper back plate and the lower back plate the upper part of the suspender is connected in a snap ring of the upper back plate the lower part is connected with the waist belt penetrating the lower back plate and a height-adjustable retractable draw bar of the back rod is fixed by a locking bolt. The back infusion stand has the advantages of good appearance, light weight, and convenient and reliable use. Wearing the back infusion stand, the patient with a mild disease can be free to engage in the activities of playing chess, reading, and walking, thereby relieving the pain of long-term bedridden. By using the nylon fastener to connect the suspender, the back infusion stand has the advantages of more convenient manufacture, easy assembly, easy large-scale production and low production cost. The product is more convenient, safer, and effort-saving for the patients, and is popular with the using units, so that the product can achieve good social and economic benefits after popularization and application.

KONGCHI ZHANG

32

Resin Film Infusion  

UK PubMed Central (United Kingdom)

This investigation completed the verification of a three-dimensional resin transfer molding/resin film infusion (RTM/RFI) process simulation model. The model incorporatesresin flow through an anisotropic carbon fiber preform, cure kinetics of the resin, and heattransfer within the preform/tool assembly. The computer model can predict the flow frontlocation, resin pressure distribution, and thermal profiles in the modeled part.

Prof Romesh; C. Batra; Prof Eric; R. Johnson; Aaron C. Caba

33

Infusion alarming devices  

UK PubMed Central (United Kingdom)

The utility model discloses an infusion alarming device comprising an outer shell, a hanging ring arranged at the upper part of the outer shell, a hook arranged at the lower part of the outer shell and used to hang infusion bottles or infusion bags and a weight detection device arranged in the outer shell. The weight detection device comprises a pull ring connected with the hook, a quartz sensor fixed in the outer shell and a weight detection signal processing device. A support point is arranged at the upper part of the pull ring. The pull ring freely supports the top of the quartz sensor through the support point. The weight detection signal processing device comprises two oscillating circuits, an isolation circuit, a signal shaping circuit, a MCU and an alarming circuit. The two oscillating circuits are connected through the isolation circuit and the signal shaping circuit. The signal shaping circuit and the alarming circuit are respectively connected with the MCU. The utility model has the advantages of a low cost, a high sensitivity of detection and a good reliability.

CHENG YU

34

Infusion Pressure Monitoring System  

UK PubMed Central (United Kingdom)

An infusion pressure monitoring system for a phacoemulsification or vitrectomy machine to be operated by a health care provider includes an irrigation path configured to carry an irrigation solution to a surgical site and a fluid sensor configured to detect a fluid parameter in the irrigation path. An input device receives a variable fluid flow command from the health care provider commanding an irrigation fluid flow through the irrigation path at a flow rate corresponding to the command. A controller communicates with both the fluid sensor and the input device. The controller determines an expected fluid pressure value and a dynamically variable threshold pressure value based upon the variable fluid flow command.

INJEV VALENTINE P

35

[Intraosseous infusion in children  

UK PubMed Central (United Kingdom)

OBJECTIVE: To assess the benefits and drawbacks of intraosseous infusion (IOI) for emergency therapy in children. STUDY DESIGN: Retrospective, non comparative study of IOI carried out between January 1994 and June 1998. PATIENTS: Forty-one children requiring without delay IOI either in the emergency medical ambulance or the emergency admission and intensive therapy units. METHODS: The tibia was punctured by paediatricians either with Mallarmé's trocars in 1994 or Cook Critical Care trocars from 1995 on. RESULTS: Overall, 46 IOI have been carried out in 41 children with a median age of 18 months (range: 8 days-9 years). The main indications for IOI were the management of near drowning, road traffic accidents and cardiopulmonary resuscitation. Complications included one articular puncture and nine subcutaneous extravasations, requiring the puncture of the other limb in five cases. CONCLUSION: IOI is an easy technique for vascular access. It is indicated in emergency cases when, after a delay of five minutes, other techniques have failed.

Claudet I; Alberge C; Bloom MC; Friès F; Lelong-Tissier MC

1999-03-01

36

ANSWER: Complications of intraosseous infusion.  

Directory of Open Access Journals (Sweden)

Full Text Available (Refer to page 209)Answer: Osteomyelitis of the tibia following intraosseous infusionIn critically ill or injured paediatric patients, intraosseous infusion (IO) provides rapid access to the systemic venous circulation. This has replaced venous cut-down and central line insertion in emergency situations, being included in standard protocols and trainingprocedures recommended by most specialty associations and societies.

Ketan PANDE; Kylath George MAMMAN

2011-01-01

37

Vacuum-attached infusion terminal.  

UK PubMed Central (United Kingdom)

A vacuum-attached infusion terminal for use in vitrectomy procedures has the advantage of being rapidly positioned in the eye through a 20-gauge pars plana incision. The terminal can be used as a temporary infusion source or throughout an entire vitrectomy procedure.

May DR; Dignam BJ

1983-05-01

38

Comparing subcutaneous fluid infusion with intravenous fluid infusion in children.  

UK PubMed Central (United Kingdom)

INTRODUCTION: This study examined subcutaneous (SC) infusion as a parenteral alternative for children with mild to moderate illness. The purpose was to compare the difference in infusion start time of parenteral fluid between an initial SC order and an initial intravenous (IV) order. In addition, the number of needlesticks a child received for each method was evaluated. This study also sought to address the following question: If SC fluids were given and an IV attempt was made later, did the administration of SC fluids enhance the success of venous cannulation? METHODS: A retrospective descriptive design was used for review of medical records for 36 children from November 2008 to May 2010 who had received SC fluids only or received SC fluids after 2 or more failed IV attempts. RESULTS: The IV/SC group had significantly longer time to infusion (M = 97.33 minutes) than did the SC group (M = 20.95 minutes; U = .000; P < .001). The IV/SC group included the number of needlesticks for the intravenous attempts plus the needle stick needed for the subcutaneous infusion. A significant difference was found between the 2 groups (mean IV = 4.87; mean SC = 1; Z = .000; P < .001). DISCUSSION: In a child who is not seriously ill, SC infusions appear to facilitate the initiation of parenteral rehydration. SC infusions minimized the number of needlesticks a child endured. More study is needed to determine if SC fluids enhance success of subsequent venous cannulation.

Kuensting LL

2013-01-01

39

The extra burden of infliximab infusions in inflammatory bowel disease.  

UK PubMed Central (United Kingdom)

BACKGROUND: Infliximab (IFX) infusions require repeated hospitalizations. The median duration of each hospitalization stay, including time for infusion and the cost for the health care system, are unknown. We assessed the extra burden of IFX infusions in inflammatory bowel disease (IBD). METHODS: This was a prospective cross-sectional study enrolling all consecutive patients with IBD treated with IFX at the Nancy IBD Unit (January to March 2012). Four parameters were assessed: median travel duration, median time that patients stayed at the IBD unit, reimbursement for transport by the health care system, and impact of IFX infusions on their work. RESULTS: Among 137 IBD patients, 48.9% were women, 74.5% had Crohn's disease, and the median age was 35 (range, 18-65) years. The median travel duration backward and forward from home to the Nancy IBD unit was 2 (range, 0.5-4) hours. The patients stayed at the IBD unit for a median period of 4.5 (range, 2.8-6.7) hours. For 63.5% of the patients (87/137), transport was reimbursed by the health care system. Of the patients receiving IFX infusions, 10.9% (15/137) were unemployed, 24.8% (34/137) had the agreement of their employer to spend 1 day at the hospital for their IFX infusion, 27.0% (36/137) asked specifically a vacation for the IFX infusion, and 13.9% (19/137) were in sick leave. CONCLUSIONS: The patients spend a median of 6.5 hours outside their home for each IFX infusion, and they often take a day of vacation or rest. This represents an extra burden for IFX-treated patients and for the health care system.

Buisson A; Seigne AL; D?huart MC; Bigard MA; Peyrin-Biroulet L

2013-10-01

40

Survival of intravenous chemotherapy infusion sites.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Factors associated with the failure of intravenous infusions due to phlebitis and extravasation were studied with 218 infusions delivering cytotoxic drugs. The survival rate of these infusions was not significantly different from that of 56 non-cytotoxic infusions in oncology patients. Although surv...

Hecker, J. F.

 
 
 
 
41

Abandonment of infusion in production workings in the Ruhr coalfield; Traenkverzicht in Gewinnungsbetrieben im Ruhrkarbon  

Energy Technology Data Exchange (ETDEWEB)

Infusion of coal before extraction is a measure to reduce dust both from the point of view of health protection as well as fire and explosion protection. However, the effectiveness of infusion is higher in highly coalified sections of seams than in sections with low coalification. The highly effective dust suppression measures in the area of coal winning by cutting and stripping have meanwhile allowed the infusion effect to recede into the background, so that it is possible to dispense with this measure in seam areas with low coalification. It was proved in practical tests that the effectiveness of the infusion is no longer detectable, if optimised secondary dust suppression methods are used. Nowadays infusion work can be dispensed with in stratigraphically young seams during coal winning, if it is guaranteed that mining authority requirements to ensure lower dust pollution are met. (orig.)

Kadow, T.; Suedhofer, F. [Deutsche Steinkohle AG, Herne (Germany); Henke, B.

2004-03-18

42

SAFETY CONNECTOR FOR INFUSION THERAPY  

UK PubMed Central (United Kingdom)

A safety connector for infusion therapy for several feeding lines has a housing (1) in which is arranged a chamber (4) delimited by a substantially cylindrical inner wall (5) of the housing, into which open several infusion line connecting channels (2) and which has an outflowing channel (9) for connecting to an outflowing line. An elastic and ring-shaped valve body lies with its cylindrical outer wall on the inner wall (5) of the housing which encloses the chamber (4). The cylindrical bearing surfaces between the ring-shaped valve body and the cylindrical inner wall (5) which encloses the chamber (4) ensure already at low bearing forces a high tightness of the nonreturn valves. The sealing force can be accurately determined down to very low pressures. A safety connector is thus for the first time created which is suitable for gravity infusion systems.

Haindl Hans Dr.

43

Myocardial infarction after rituximab infusion.  

UK PubMed Central (United Kingdom)

Myocardial infarction after rituximab or other monoclonal antibody therapies has been reported in rare cases, all in patients with classical cardiovascular risk factors or associated inflammatory or lymphoproliferative disorders. We report the case of a 52-year-old man, without classical cardiovascular risk factors or associated inflammatory or lymphoproliferative disorder, treated for seronegative myasthenia with rituximab infusions complicated by myocardial infarction. The exact origin of myocardial infarction after monoclonal antibody treatment is unclear. Myocardial infarction is a rare but possibly fatal complication of rituximab infusion, even occurring in relatively young patients, without classical risk factors and without associated inflammatory or lymphoproliferative disorder.

Renard D; Cornillet L; Castelnovo G

2013-07-01

44

Prolonged fever after Infliximab infusion  

Directory of Open Access Journals (Sweden)

Full Text Available Pharmacologic management for ulcerative colitis (UC) has recently been expanded to include anti- tumor necrosis factor (TNF) therapy for severe disease. Infliximab, a chimeric monoclonal antibody directed again TNF ? was first tested in patients with Crohn’s disease. In addition to serious infections, malignancy, drug induced lupus and other autoimmune diseases, serum sickness-like reactions, neurological disease, and infusion reactions further complicate the use of Infliximab. We report a case of prolonged fever after Infliximab infusion to treat steroid refractory UC.

Jennifer Katz; Michael Frank

2012-01-01

45

[The intraosseous infusion in adult].  

UK PubMed Central (United Kingdom)

Intraosseous infusion is an old knowledge, abandoned in the 1950s in favor of the peripheral vein, and it was essentially described in pediatrics and military medicine. Since 2005, this way is experiencing a resurgence of interest in emergency medicine particularly in adults after the failure's installation of a peripheral vein in order not to waste the time of care and administration of treatment. New devices that allow intraosseous infusion are currently used in humans. We propose to review the different kind of catheters used, to know the main technical characteristics, indications, contraindications and potential complications. We propose a comparison with the peripheral vein and a comparison between the different catheters.

Plancade D; Rüttimann M; Wagnon G; Landy C; Schaeffer E; Gagnon N; Nadaud J; Favier JC

2013-05-01

46

The impact of colloid infusion prior to spinal anaesthesia for caesarean section on the condition of a newborn--a comparison of balanced and unbalanced hydroxyethyl starch 130/0.4.  

UK PubMed Central (United Kingdom)

BACKGROUND: Fluid therapy is the most commonly used treatment to prevent hypotension associated with spinal anaesthesia. The aim of this study was to test the hypothesis that a balanced solution of 6% hydroxyethyl starch will have a more beneficial impact on the condition of newborns at birth than an unbalanced 6% solution of HES. METHODS: The study participants included 51 healthy parturients undergoing elective caesarean section with spinal anaesthesia. Patients received a transfusion of 500 mL of unbalanced 6% HES (Voluven) or balanced 6% HES (Tetraspan) prior to anaesthesia. The condition of the newborn was assessed using the Apgar score, and the acid-base balances of venous and arterial umbilical cord blood were also measured. RESULTS: The incidence of hypotension after spinal anaesthesia was 80% in Group A and 76.9% in Group B (P = 1.0). There were no differences between the two groups in the total doses of ephedrine and no differences between treatment groups in Apgar scores. Also, no differences in acid-base balance parameters (pH, H(+), pCO(2), pO(2), HCO(3)(-), BE) were found. CONCLUSION: A balanced 6% solution of hydroxyethyl starch (HES 130/0.42) did not significantly influence the condition of the newborns at birth or the acid-base and electrolyte concentration of newborns compared to an unbalanced solution of 6% hydroxyethyl starch (HES 130/0.4).

Marciniak A; Wujtewicz M; Owczuk R

2013-01-01

47

Infusion of radionuclides throughout pregnancy  

International Nuclear Information System (INIS)

This work is part of a long-term study to examine the cancer incidence in the offspring of mice exposed to 239Pu or 147Pm throughout pregnancy. The need to model the human intake scenario and the possibility of a critical period during uterine development necessitates constant availability of radionuclides throughout pregnancy. Various methods (multiple daily injections, infusion by external cannula and infusion by indwelling osmotic pump) have been examined and osmotic infusion pumps chosen. These pumps result in a near-constant blood concentration for up to 21 days. Part of the study is the estimation of dose to the critical haemopoietic tissues of the pup from a knowledge of the radionuclide distribution and kinetics. At present the distribution has been followed from birth to 180 days. Activity in the suckling pups at 7 days old is around 1 percent of the infused activity, though most of this is accounted for by the contents of the stomach and gastrointestinal tract. The liver and femur account for around 0.025 percent and 0.012 percent respectively per pup. Activity increases in both liver and femur during lactation after which both concentration and activity fall with time. Long-term studies with the pups of dams exposed to a range of 239Pu concentrations between 0-70 kBq/kg are underway. Correlation of average organ dose with tumour incidence will be determined at completion of the life-span study. (Author) 39 refs., 5 tabs., 6 figs

1991-06-00

48

Propofol infusion syndrome or adrenoleukodystrophy?  

UK PubMed Central (United Kingdom)

Following a propofol anesthetic, a 5-year-old girl with lower extremity spasticity seized and developed hypertriglyceridemia, hyperkalemia, and metabolic acidosis. A presumed diagnosis of propofol infusion syndrome (PRIS) was made, but further investigation revealed neonatal adrenoleukodystrophy. PRIS should be considered with this constellation of symptoms, but other neurometabolic disorders must always be ruled out.

Karaman Y; Goktay A; Agin H; Karaarslan U

2013-04-01

49

Cerebral oxygenation following epinephrine infusion.  

Science.gov (United States)

Evidence suggests that the autonomic nervous system may actively regulate the cerebral vasculature. In this study, central hemodynamics and brain oxy-hemoglobin, deoxy-hemoglobin and total hemoglobin changes (bO?Hb, bdHb and bTHb) were monitored during infusion of epinephrine (0.06 ?g/kg/min over 6 min, and 0.12 ?g/kg/min for 3 min) in 12 men. Epinephrine decreased mean arterial pressure (MAP) and total peripheral resistance (TPR), while heart rate (HR), stroke volume (SV) and cardiac output (CO) increased, but did not affect bO?Hb, bdHb or bTHb. However, upon the cessation of epinephrine infusion an increase in both Oxy- and Total Hb occurred which peaked at 3 min post infusion (+6.0±4.6 and +4.9±4.8 ?mol/L respectively, P<0.05) and persisted for 20 min post infusion (+1.5±2.2 and +1.8±2.7 ?mol/L respectively, P<0.05). No evidence was found for reduction in cerebral oxygenation during a cold-pressor test. The results of the present study demonstrated that clinical doses of epinephrine result in a delayed increase in cortical blood volume due to an increase in Oxy-Hb, consistent with vasodilation. PMID:22853845

Steinback, Craig D; Zubin, Petra; Breskovic, Toni; Bakovic, Darija; Pivac, Nediljko; Dujic, Zeljko

2012-07-31

50

Cerebral oxygenation following epinephrine infusion.  

UK PubMed Central (United Kingdom)

Evidence suggests that the autonomic nervous system may actively regulate the cerebral vasculature. In this study, central hemodynamics and brain oxy-hemoglobin, deoxy-hemoglobin and total hemoglobin changes (bO?Hb, bdHb and bTHb) were monitored during infusion of epinephrine (0.06 ?g/kg/min over 6 min, and 0.12 ?g/kg/min for 3 min) in 12 men. Epinephrine decreased mean arterial pressure (MAP) and total peripheral resistance (TPR), while heart rate (HR), stroke volume (SV) and cardiac output (CO) increased, but did not affect bO?Hb, bdHb or bTHb. However, upon the cessation of epinephrine infusion an increase in both Oxy- and Total Hb occurred which peaked at 3 min post infusion (+6.0±4.6 and +4.9±4.8 ?mol/L respectively, P<0.05) and persisted for 20 min post infusion (+1.5±2.2 and +1.8±2.7 ?mol/L respectively, P<0.05). No evidence was found for reduction in cerebral oxygenation during a cold-pressor test. The results of the present study demonstrated that clinical doses of epinephrine result in a delayed increase in cortical blood volume due to an increase in Oxy-Hb, consistent with vasodilation.

Steinback CD; Zubin P; Breskovic T; Bakovic D; Pivac N; Dujic Z

2012-10-01

51

Acute pseudogout after pamidronate infusion.  

UK PubMed Central (United Kingdom)

A 72-year-old man, treated with a 60-mg intravenous infusion of pamidronate for shoulder hand syndrome, developed after few hours an acute pseudogout arthritis of his right knee. Diagnosis was confirmed by synovial fluid analysis and was associated with hypocalcemia. Only a few cases are reported in the literature. The mechanism of this potential side effect remains speculative.

Wendling D; Tisserand G; Griffond V; Saccomani C; Toussirot E

2008-09-01

52

Acute pseudogout after pamidronate infusion.  

Science.gov (United States)

A 72-year-old man, treated with a 60-mg intravenous infusion of pamidronate for shoulder hand syndrome, developed after few hours an acute pseudogout arthritis of his right knee. Diagnosis was confirmed by synovial fluid analysis and was associated with hypocalcemia. Only a few cases are reported in the literature. The mechanism of this potential side effect remains speculative. PMID:18500436

Wendling, Daniel; Tisserand, Guillaume; Griffond, Vincent; Saccomani, Clarisse; Toussirot, Eric

2008-05-24

53

Infusing Culture in Career Counseling  

Science.gov (United States)

|This article introduces the culture-infused career counselling (CICC) model. Six principles are foundational to a tripartite model emphasizing cultural self-awareness, awareness of client cultural identities, and development of a culturally sensitive working alliance. The core competencies ensure the cultural validity and relevance of career…

Arthur, Nancy; Collins, Sandra

2011-01-01

54

Remifentanil infusion prolongs spinal anesthesia.  

UK PubMed Central (United Kingdom)

Spinal anesthesia was given to a patient undergoing transurethral resection ofprostate (TURP). A total of 3.2 ml of bupivacaine 0.5% mixed with fentanyl 20 mcg were used. The patient started experiencing sensation after 150 min. Remifentanil intravenous infusion prolonged the duration of anesthesia for an additional 105 minutes.

Soliman MH; Ibrahim SM; Saeed K; El-Omrani H; Kokach O

2013-02-01

55

Hypodermoclysis: an alternative infusion technique.  

UK PubMed Central (United Kingdom)

Hypodermoclysis, the subcutaneous infusion of fluids, is a useful and easy hydration technique suitable for mildly to moderately dehydrated adult patients, especially the elderly. The method is considered safe and does not pose any serious complications. The most frequent adverse effect is mild subcutaneous edema that can be treated by local massage or systemic diuretics. Approximately 3 L can be given in a 24-hour period at two separate sites. Common infusion sites are the chest, abdomen, thighs and upper arms. The preferred solution is normal saline, but other solutions, such as half-normal saline, glucose with saline or 5 percent glucose, can also be used. Potassium chloride can be added to the solution bag if needed. Hyaluronidase can also be added to enhance fluid absorption. Hypodermoclysis can be administered at home by family members or a nurse; the technique should be familiar to every family physician.

Sasson M; Shvartzman P

2001-11-01

56

Hypodermoclysis: an alternative infusion technique.  

Science.gov (United States)

Hypodermoclysis, the subcutaneous infusion of fluids, is a useful and easy hydration technique suitable for mildly to moderately dehydrated adult patients, especially the elderly. The method is considered safe and does not pose any serious complications. The most frequent adverse effect is mild subcutaneous edema that can be treated by local massage or systemic diuretics. Approximately 3 L can be given in a 24-hour period at two separate sites. Common infusion sites are the chest, abdomen, thighs and upper arms. The preferred solution is normal saline, but other solutions, such as half-normal saline, glucose with saline or 5 percent glucose, can also be used. Potassium chloride can be added to the solution bag if needed. Hyaluronidase can also be added to enhance fluid absorption. Hypodermoclysis can be administered at home by family members or a nurse; the technique should be familiar to every family physician. PMID:11730312

Sasson, M; Shvartzman, P

2001-11-01

57

Rapid rituximab infusion, local center experience.  

UK PubMed Central (United Kingdom)

Rituximab, a chimeric monoclonal antibody (MoAb) targeting CD20 has been widely used in the management of B-cell lympho-proliferative disorders.(1-3) The usual recommended schedule of regular administration over 3 to 4 hours requires considerable healthcare resources and oftentimes inconvenient for patients. Literature shows the availability of published reports proving the safety and feasibility of rapid infusion of rituximab. This study explored the safety and tolerability of rituximab infusion over a shorter total infusion time. A total of 24 patients diagnosed with CD20+ Non-Hodgkin's lymphoma and planned to receive rituximab at a dose of 375mg/m2 in combination with standard chemotherapy regimens were included in the study from January 2009 to December 2009. The administration of first rituximab dose was unaltered and given as per standard practice of 3-4 hours infusion. The second and subsequent doses were delivered over a total infusion time of only 90 minutes (20% of dose in the first 30 minutes, remaining 80% over the next 60 minutes). These patients, aged between 15 and 79 years, received a total of 152 rituximab infusions with an average of 6.33 (+/-2.37) infusions per patient. Grade 1 infusion related toxicity was reported in 5 infusions (3.2%), and there were no acute reactions or G3/4 toxicity in any infusion episode. A rapid infusion of rituximab is well tolerated, feasible and safe when administered as second and subsequent infusions in the course of therapy for those who tolerate the first dose without significant infusion related toxicity. This shortened infusion method results in a substantial reduction in resource utilization. Our institution has now adopted this as a routine practice. Keywords: Rituximab, Short infusion, Oman.

Monem EA; Al-Bahrani B; Mehdi I; Nada A

2013-07-01

58

Rapid rituximab infusion, local center experience.  

Science.gov (United States)

Rituximab, a chimeric monoclonal antibody (MoAb) targeting CD20 has been widely used in the management of B-cell lympho-proliferative disorders.(1-3) The usual recommended schedule of regular administration over 3 to 4 hours requires considerable healthcare resources and oftentimes inconvenient for patients. Literature shows the availability of published reports proving the safety and feasibility of rapid infusion of rituximab. This study explored the safety and tolerability of rituximab infusion over a shorter total infusion time. A total of 24 patients diagnosed with CD20+ Non-Hodgkin's lymphoma and planned to receive rituximab at a dose of 375mg/m2 in combination with standard chemotherapy regimens were included in the study from January 2009 to December 2009. The administration of first rituximab dose was unaltered and given as per standard practice of 3-4 hours infusion. The second and subsequent doses were delivered over a total infusion time of only 90 minutes (20% of dose in the first 30 minutes, remaining 80% over the next 60 minutes). These patients, aged between 15 and 79 years, received a total of 152 rituximab infusions with an average of 6.33 (+/-2.37) infusions per patient. Grade 1 infusion related toxicity was reported in 5 infusions (3.2%), and there were no acute reactions or G3/4 toxicity in any infusion episode. A rapid infusion of rituximab is well tolerated, feasible and safe when administered as second and subsequent infusions in the course of therapy for those who tolerate the first dose without significant infusion related toxicity. This shortened infusion method results in a substantial reduction in resource utilization. Our institution has now adopted this as a routine practice. Keywords: Rituximab, Short infusion, Oman. PMID:23996867

Monem, E A; Al-Bahrani, B; Mehdi, I; Nada, A

2013-07-01

59

Infusion medicament for treating impetigo  

UK PubMed Central (United Kingdom)

The invention discloses a traditional Chinese medicine medicament, namely an infusion medicament for curing impetigo. The medicament is prepared by raw material with the following parts by weight, such as yellow alley stone 100g, lycium Chinese mill 60g, Ligusticum wallichii 60g and black catechu 50g. The invention has the advantages of novel formula, low cost, simple preparation, convenient employment and obvious effect.

DONGJIAN XU; PINGER XU; YUANBEN XU

60

Antiproliferative activities of tea and herbal infusions.  

UK PubMed Central (United Kingdom)

The consumption of tea and herbal infusions has increased rapidly in recent years. More and more people consume these infusions as daily beverages as well as for health purposes. The aim of this study was to supply new information on the antiproliferative function of these infusions for nutritionists and the general public. The in vitro antiproliferative activities of 60 different tea and herbal infusions on four cancer cell lines were evaluated by MTT assay. The results showed that some infusions strongly inhibited the proliferation of A549 (human lung cancer cells), MCF-7 (human breast cancer cells), HepG2 (human hepatoma cells) and HT-29 (human colon cancer cells), and decreased the viability of these cancer cell lines in a dose-dependent manner. In addition, some bioactive components in the infusions were also separated and determined by HPLC. The results suggested that some tea and herbal infusions may be potential dietary supplements for the prevention and treatment of cancer.

Li F; Li S; Li HB; Deng GF; Ling WH; Xu XR

2013-04-01

 
 
 
 
61

Variable flow infusion pump system  

UK PubMed Central (United Kingdom)

An implantable infusion pump system is disclosed. The pump system preferably includes an implantable pump and a removable module. The module may provide for varying flow rates of fluid being dispensed from the pump or may provide for a constant flow rate of such fluid. In the case of varying flow rate capabilities, the module preferably includes one or more sensors to determine information relating to the flow rate, electronics for analyzing the flow rate information, and a mechanism for physically altering the flow rate. Methods of dispensing a medicament to a patient are also disclosed, as are variations of the pump system.

STEINBACH BERND; WALLMANN FRANK; LEDERER KLAUS G; SAAR DAVID; DAVID SIDNEY

62

VARIABLE FLOW INFUSION PUMP SYSTEM  

UK PubMed Central (United Kingdom)

An implantable infusion pump system is disclosed. The pump system preferably includes an implantable pump and a removable module. The module may provide for varying flow rates of fluid being dispensed from the pump or may provide for a constant flow rate of such fluid. In the case of varying flow rate capabilities, the module preferably includes one or more sensors to determine information relating to the flow rate, electronics for analyzing the flow rate information, and a mechanism for physically altering the flow rate. Methods of dispensing a medicament to a patient are also disclosed, as are variations of the pump system.

STEINBACH BERND; WALLMANN FRANK; LEDERER KLAUS G; SAAR DAVID; DAVID SIDNEY

63

Intraosseous infusion of hypertonic glucose and dopamine.  

UK PubMed Central (United Kingdom)

Intraosseous infusion of drugs for resuscitation and of fluids has been advocated as an alternate emergency technique to intravenous infusion. The reliability of intraosseous infusion of many substances has not been established. Glucose and dopamine hydrochloride are two commonly used emergency drugs in pediatric practice that have not been carefully studied when administered into the bone marrow. In an animal model, we compared the response of an intraosseous injection of hypertonic glucose with that of an intravenous injection of hypertonic glucose. Serum glucose measurements following the injection revealed both routes of administration to be effective. A dopamine infusion was then administered through the bone marrow for 20 minutes. A statistically significant rise in blood pressure was observed two minutes after initiation of the infusion. Intraosseous infusion of hypertonic glucose and dopamine is an effective route by which to administer these medications and is potentially useful in emergency situations in which intravascular access is delayed.

Neish SR; Macon MG; Moore JW; Graeber GM

1988-08-01

64

Persistent hiccups with continuous intrathecal morphine infusion.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To report a case of hiccups secondary to intrathecal (IT) morphine infusion. METHODS: Case report and discussion. RESULTS: The hiccups in our patient resolved on substitution of IT morphine infusion with hydromorphone. DISCUSSION: We report a case of a 44-year-old man who developed persistent hiccups with IT morphine infusion pump therapy. The hiccups persisted despite various nonpharmacological and pharmacological measures. The untoward symptom resolved after substitution of IT hydromorphone for IT morphine.

Loomba V; Gupta M; Kim D

2012-02-01

65

Air-embolism prevention infusion apparatus  

UK PubMed Central (United Kingdom)

The utility model relates to an air-embolism prevention infusion apparatus, which comprises a liquid taking needle tube, an upper infusion tube, a Murphy's dropper, a dropper, a lower infusion tube, a flow control valve sleeved on the lower infusion tube and an infusion needle. The infusion apparatus is characterized in that the Murphy's dropper takes the shape of a cone, wherein the inner diameter of one end of the Murphy's dropper connected with the upper infusion tube is larger than that of the end connected with the lower infusion tube a floating stop ball is arranged in the Murphy's dropper, of which the diameter is equal to that of the lower end of the Murphy's dropper and the stop ball can rise and decline along with the height of liquid medicine by means of the buoyancy force of the liquid medicine in the Murphy's dropper and the self gravity, thereby efficiently stopping air from entering after the liquid medicine in a medicine bottle is used up. Therefore, the structure can effectively prevent accidents caused by air embolism after an infusion is finished, and ensure the health of patients and in addition, the utility model also has the advantages of simple structure and time and labor conservation.

NUO XU; LILI MIAO

66

Safety of rapid intravenous of infusion acetaminophen.  

UK PubMed Central (United Kingdom)

Intravenous acetaminophen, Ofirmev®, is approved for management of mild to moderate pain, management of moderate to severe pain with adjunctive opioids, and reduction of fever. The product is supplied as a 100 mL glass vial. As stated in the prescribing information, it is recommended to be infused over 15 minutes. This recommendation is related to the formulation propacetamol, the prodrug to acetaminophen, approved in Europe, which caused pain on infusion, and data from the clinical development of acetaminophen. The objective of this retrospective chart review study was to show the lack of side effects of rapidly infusing intravenous acetaminophen. Charts of American Society of Anesthesiology (ASA) Class I-III ambulatory surgical patients who received only acetaminophen in the preoperative setting were reviewed for any infusion-related side effects. Using standard binomial proportion analyses and employing SAS/JMP software, all vital signs were analyzed for statistically significant changes between pre- and postinfusion values. One hundred charts were reviewed. Only one patient had pain on infusion, which lasted 10 seconds. No reported side effects or erythema was seen at the injection site. No infusions had to be slowed or discontinued. The median infusion time was 3:41 minutes. Of the vital signs monitored, only the systolic (P < 0.0001) and diastolic (P < 0.0099) blood pressures had statistically significant changes from pre- to postinfusion; however, they were of no clinical relevance. Acetaminophen can be administered as a rapid infusion with no significant infusion-related side effects or complications.

Needleman SM

2013-07-01

67

Cetuximab infusion reactions: French pharmacovigilance database analysis.  

UK PubMed Central (United Kingdom)

OBJECTIVES: To compare characteristics of patients exhibiting cetuximab infusion reactions or another adverse drug reaction related to cetuximab and to identify factors associated with the severity of cetuximab infusion reactions. METHODS: All cases of adverse drug reaction reported with cetuximab from 1985 to 2010 were extracted from the French Pharmacovigilance database. The severity of infusion reactions was assessed according to the NCI-CTCAE criteria (v4.0). Multiple logistic regression analysis was performed to identify factors associated with the severity of infusion reactions. RESULTS: Among the 602 adverse drug reaction reported with cetuximab during the study period, 374 infusion reactions were identified. Indication is more likely to be head and neck than colorectal cancer among patients experiencing an infusion reaction (p < 0.001). Among the seven deaths related to an infusion reaction, five patients were treated for head and neck cancer. Infusion reactions were more likely to be severe when they occurred during the first administration (OR = 7.40 95% CI [2.21-24.71]), adjusted for age, sex, region of France, quarter of the year, indication, year of occurrence, and premedication. CONCLUSION: Our study found that reports of infusion reactions more often concerned patients treated for head and neck cancer, that in these patients the adverse drug reaction was more often fatal and severe infusion reactions were more likely during the first administration. In daily practice, the close monitoring of patients during the first infusion, especially patients with head and neck cancer, is recommended. Considering the possible immunoglobulin E-mediated mechanism, reliable tests for their detection need to be readily available.

Grandvuillemin A; Disson-Dautriche A; Miremont-Salamé G; Fourrier-Reglat A; Sgro C

2013-06-01

68

Effects of portal infusion of hypertonic solution on jejunal electrolyte transport in anesthetized dogs.  

UK PubMed Central (United Kingdom)

Jejunal electrolyte absorption was measured in the jejunal loops of anesthetized dogs during infusions of hypertonic solutions via the portal vein. The net Na absorption was not influenced by the 9% NaCl infusion into the inferior vena cava, although it was significantly attenuated by the portal 9% NaCl infusion. This effect may not be due to the osmotic stimulus, since the portal 50% glucose or 6.5% LiCl infusion had no significant influence on the net Na absorption. To determine the mechanism of the decrease in the net Na absorption during the portal hypertonic NaCl infusion, the net Na absorption was measured after the section of anterior and posterior hepatic nerves (SAPH) or intravenous atropine injection. Both SAPH and the intravenous atropine injection completely blocked the effect of the portal 9% NaCl infusion on the net Na absorption. These results indicate that 1) net Na absorption in dog jejunum is depressed by the hypertonic NaCl infusion via the portal vein; 2) the effect is NaCl specific and may not be due to the osmotic stimulus; and 3) the afferent limbs of this effect are the anterior and posterior hepatic nerves, and the efferent limb of this effect is the vagus nerve. Thus the hepatojejunal reflex may play an important role in the regulation of body fluid homeostasis.

Morita H; Ohyama H; Hagiike M; Horiba T; Miyake K; Yamanouchi H; Matsushita K; Hosomi H

1990-12-01

69

Finger actuated medication infusion system  

UK PubMed Central (United Kingdom)

A Finger Actuated Medication Infusion System (FAMIS) (5) for delivering a dosage of medication into a living body. The FAMIS is fully mechanical and comprises a reservoir (10), a pump (60) and connecting catheters (58). The reservoir (10) includes a sealed bellows portion (21) which contains a pressurant and exerts a substantially constant pressure on the medication in the reservoir (10), regardless of the amount of medication therein. The pump (60) includes a bellows assembly (81) disposed within an equalizing pressure chamber (63), and will deliver medication through the bellows assembly (81) at a predetermined flow rate independent of ambient temperature, ambient pressure or the amount of medication remaining in the reservoir (10). The FAMIS design also provides safeguards against inadvertant overdosing, transmission of bacteria into the body and prevents gas bubbles within the reservoir (10) from impeding the flow of medication through an outlet flow restrictor (98) which forms part of the FAMIS pump (60).

Fischell David R.

70

Finger actuated medication infusion system  

UK PubMed Central (United Kingdom)

A Finger Actuated Medication Infusion System (FAMIS) for delivering a dosage of medication into a living body. The FAMIS is fully mechanical and comprises a reservoir, a pump and connecting catheters. The reservoir includes a sealed bellows portion which contains a pressurant and exerts a substantially constant pressure on the medication in the reservoir, regardless of the amount of medication therein. The pump includes a bellows assembly disposed within an equalizing pressure chamber, and will deliver medication through the bellows assembly at a predetermined flow rate independent of ambient temperature, ambient pressure or the amount of medication remaining in the reservoir. The FAMIS design also provides safeguards against inadvertant overdosing, transmission of bacteria into the body and prevents gas bubbles within the reservoir from impeding the flow of medication through an outlet flow restrictor which forms part of the FAMIS pump.

FISCHELL DAVID R; FISCHELL TIM A

71

Propofol-Related Infusion Syndrome  

Directory of Open Access Journals (Sweden)

Full Text Available Background: Propofol is a drug that is used for induction of anaesthesia at surgery. Its use is sometimesassociated with sudden hemodynamic instability, which may be life-threatening.Aim & Objectives: To report the occurrence of the propofol-related infusion syndrome in a child.Methods/Study Design: A 13 year- old girl who received a bolus dose of propofol for induction ofanaesthesia at surgery developed sudden hemodynamic instability.Results/Findings: Investigations suggested that the child had developed propofol- related infusionsyndrome. Close monitoring and supportive management eventually enabled the patient to recover fromthis dreaded complication.Study Limitations: It was not possible to determine the exact reason why the child developed thissyndrome.Conclusion: An accurate specific diagnosis of this condition and prompt institution of appropriatetherapy aid recovery from this syndrome.

Joseph Theodore; A. Radhakrishnan

2011-01-01

72

VARIABLE FLOW INFUSION PUMPS SYSTEM.  

UK PubMed Central (United Kingdom)

An implantable infusion pump system is disclosed. The pump system preferably includes an implantable pump (800) and a removable module (820, 820'). The module (820, 820') may provide for varying flow rates of fluid being dispensed from the pump or may provide for a constant flow rate of such fluid. In the case of varying flow rate capabilities, the module (820, 820') preferably includes one or more sensors (830, 831) to determine information relating to the flow rate, electronics (844, 846, 835, 844e, 844f, 849, 848, 850, 851, 853, 854, 855, 856) for analyzing the flow rate information, and a mechanism for physically altering the flow rate (821). Methods of dispensing a medicament to a patient are also disclosed, as are variations of the pump system.

STEINBACH BERND; WALLMANN FRANK; LEDERER KLAUS G; SAAR DAVID; DAVID SIDNEY

73

VARIABLE FLOW INFUSION PUMP SYSTEM  

UK PubMed Central (United Kingdom)

An implantable infusion pump system is disclosed. The pump system prefera bly includes an implantable pump (800) and a removable module (820, 820'). T he module (820, 820') may provide for varying flow rates of fluid being disp ensed from the pump or may provide for a constant flow rate of such fluid. I n the case of varying flow rate capabilities, the module (820, 820') prefera bly includes one or more sensors (830, 831) to determine information relatin g to the flow rate, electronics (844, 846, 835, 844e, 844f, 849, 848, 850, 8 51, 853, 854, 855, 856) for analyzing the flow rate information, and a mecha nism for physically altering the flow rate (821). Methods of dispensing a me dicament to a patient are also disclosed, as are variations of the pump syst em.

LEDERER KLAUS G; WALLMANN FRANK; SAAR DAVID; DAVID SIDNEY; STEINBACH BERND

74

Infusion techniques for perinatal home care.  

UK PubMed Central (United Kingdom)

Perinatal home infusion therapy is one service component of a comprehensive maternity care program. Physicians can prescribe perinatal home infusion therapies for various conditions, as an alternative to treatment in acute care settings. Maternal and fetal assessment is an integral part of the management of these therapies.

Eaton DG

1995-05-01

75

Automated segmentation tool for brain infusions.  

UK PubMed Central (United Kingdom)

This study presents a computational tool for auto-segmenting the distribution of brain infusions observed by magnetic resonance imaging. Clinical usage of direct infusion is increasing as physicians recognize the need to attain high drug concentrations in the target structure with minimal off-target exposure. By co-infusing a Gadolinium-based contrast agent and visualizing the distribution using real-time using magnetic resonance imaging, physicians can make informed decisions about when to stop or adjust the infusion. However, manual segmentation of the images is tedious and affected by subjective preferences for window levels, image interpolation and personal biases about where to delineate the edge of the sloped shoulder of the infusion. This study presents a computational technique that uses a Gaussian Mixture Model to efficiently classify pixels as belonging to either the high-intensity infusate or low-intensity background. The algorithm was implemented as a distributable plug-in for the widely used imaging platform OsiriX®. Four independent operators segmented fourteen anonymized datasets to validate the tool's performance. The datasets were intra-operative magnetic resonance images of infusions into the thalamus or putamen of non-human primates. The tool effectively reproduced the manual segmentation volumes, while significantly reducing intra-operator variability by 67±18%. The tool will be used to increase efficiency and reduce variability in upcoming clinical trials in neuro-oncology and gene therapy.

Rosenbluth KH; Gimenez F; Kells AP; Salegio EA; Mittermeyer GM; Modera K; Kohal A; Bankiewicz KS

2013-01-01

76

Automated segmentation tool for brain infusions.  

Science.gov (United States)

This study presents a computational tool for auto-segmenting the distribution of brain infusions observed by magnetic resonance imaging. Clinical usage of direct infusion is increasing as physicians recognize the need to attain high drug concentrations in the target structure with minimal off-target exposure. By co-infusing a Gadolinium-based contrast agent and visualizing the distribution using real-time using magnetic resonance imaging, physicians can make informed decisions about when to stop or adjust the infusion. However, manual segmentation of the images is tedious and affected by subjective preferences for window levels, image interpolation and personal biases about where to delineate the edge of the sloped shoulder of the infusion. This study presents a computational technique that uses a Gaussian Mixture Model to efficiently classify pixels as belonging to either the high-intensity infusate or low-intensity background. The algorithm was implemented as a distributable plug-in for the widely used imaging platform OsiriX®. Four independent operators segmented fourteen anonymized datasets to validate the tool's performance. The datasets were intra-operative magnetic resonance images of infusions into the thalamus or putamen of non-human primates. The tool effectively reproduced the manual segmentation volumes, while significantly reducing intra-operator variability by 67±18%. The tool will be used to increase efficiency and reduce variability in upcoming clinical trials in neuro-oncology and gene therapy. PMID:23755125

Rosenbluth, Kathryn Hammond; Gimenez, Francisco; Kells, Adrian P; Salegio, Ernesto A; Mittermeyer, Gabriele M; Modera, Kevin; Kohal, Anmol; Bankiewicz, Krystof S

2013-06-05

77

Hypodermoclysis or subcutaneous infusion revisited.  

UK PubMed Central (United Kingdom)

AIM OF STUDY: To review the use of hypodermoclysis in a local Hospice. METHOD: A review of all hypodermoclysis carried out over a six-month period was conducted. Special attention was paid to the reason for starting and stopping the drip, duration of the drip, complications, the type and amount of solution infused. RESULTS: Fifty-one (19%) out of 266 patients received hypodermoclysis during their stay. This constituted 5.9% of total patient-days in the study period. Vomiting and drowsiness were the main reasons for the use of drip. The commonest reason for stopping the drip was patient demise. Complications seen were drip site redness (16%), extravasation (15%) and bleeding (2.5%) There was no overt clinical sepsis in any of the patients. CONCLUSION: Hypodermoclysis is an easy and convenient means of providing hydration. The availability of a standard protocol with clearer guidelines on its use will help to reduce procedure-related complications and promote wider adoption of the practice.

Yap LK; Tan SH; Koo WH

2001-11-01

78

Financial analysis for the infusion alliance.  

UK PubMed Central (United Kingdom)

Providing high-quality, cost-efficient care is a major strategic initiative of every health care organization. Today's health care environment is transparent; very competitive; and focused upon providing exceptional service, safety, and quality. Establishing an infusion alliance facilitates the achievement of organizational strategic initiatives, that is, increases patient throughput, decreases length of stay, prevents the occurrence of infusion-related complications, enhances customer satisfaction, and provides greater cost-efficiency. This article will discuss how to develop a financial analysis that promotes value and enhances the financial outcomes of an infusion alliance.

Perucca R

2010-09-01

79

Impact of multiaccess infusion devices on in vitro drug delivery during multi-infusion therapy.  

UK PubMed Central (United Kingdom)

BACKGROUND: Multiaccess infusion sets allow multiple simultaneous infusions but may induce interference in drug delivery resulting from large variations in the delivery rate of potent drugs. In this study, we sought to understand the influence of multiaccess infusion device properties (dead space volume and antireflux valve [ARV]) on drug delivery during multi-infusion therapy. METHODS: Infusion sets differing in length, dead space volume, and presence of an ARV were assessed. Three drugs were infused simultaneously through different access points, and their concentrations were obtained using UV spectrophotometric analysis of the effluent. Different infusion configurations were compared by assessing (1) the amount of drug delivered to the patient per unit of time, (2) the mean amount of drug delivered to the patient per unit of time during the steady-state infusion (mass flow rate plateau), and (3) flow change efficiency calculated from the ratio of the area under the experimental instant mass flow rate curve to the area corresponding to theoretical instant mass flow rate curve. RESULTS: Infusion sets with lower dead space volumes offered significantly higher flow change efficiency (53.0% +/- 15.4% with a dead space volume equal to 0.046 mL 5 min after the start of infusion) than infusion sets with higher dead space volume (5.6% +/- 8.2% with a dead space volume equal to 6.16 mL), whatever the flow rate changes. Even in case of large dead space volumes, the presence of an ARV significantly increased the mass flow rate plateau (from 92.4% to 99.3% of the theoretical plateau without and with the presence of an ARV, respectively). CONCLUSIONS: Multi-infusion therapy induces perturbation in drug delivery. These perturbations (lag time, backflow, and bolus) could be reduced by using infusion sets including very low dead space volume and an ARV.

Décaudin B; Dewulf S; Lannoy D; Simon N; Secq A; Barthélémy C; Debaene B; Odou P

2009-10-01

80

A new infusion pathway intactness monitoring system.  

Science.gov (United States)

A new infusion pathway monitoring system has been developed for hospital and home use. The system consists of linear integrated circuits and a low-power 8-bit single chip microcomputer which constantly monitors the infusion pathway intactness. An AC (alternating current) voltage is induced on the patient's body by electrostatic coupling from the normal 100 volt, 60 Hz AC power line wiring field in the patient's room. The induced AC voltage can be recorded by a main electrode wrapped around the infusion polyvinyl chloride tube. A reference electrode is wrapped on the electrode to monitor the AC voltage around the main electrode. If the injection needle or infusion tube becomes detached, then the system detects changes in the induced AC voltages and alerts the nursing station, via the nurse call system or PHS (personal handy phone system). PMID:17945872

Ogawa, Hidekuni; Yonezawa, Yoshiharu; Maki, Hiromichi; Ninomiya, Ishio; Sata, Koji; Hamada, Shingo; Caldwell, W Morton

2006-01-01

 
 
 
 
81

A new infusion pathway intactness monitoring system.  

UK PubMed Central (United Kingdom)

A new infusion pathway monitoring system has been developed for hospital and home use. The system consists of linear integrated circuits and a low-power 8-bit single chip microcomputer which constantly monitors the infusion pathway intactness. An AC (alternating current) voltage is induced on the patient's body by electrostatic coupling from the normal 100 volt, 60 Hz AC power line wiring field in the patient's room. The induced AC voltage can be recorded by a main electrode wrapped around the infusion polyvinyl chloride tube. A reference electrode is wrapped on the electrode to monitor the AC voltage around the main electrode. If the injection needle or infusion tube becomes detached, then the system detects changes in the induced AC voltages and alerts the nursing station, via the nurse call system or PHS (personal handy phone system).

Ogawa H; Yonezawa Y; Maki H; Ninomiya I; Sata K; Hamada S; Caldwell WM

2006-01-01

82

A 19-gauge illuminating infusion probe.  

UK PubMed Central (United Kingdom)

A 19-gauge illuminating infusion probe has been developed and used during the past four years. This instrument is potentially useful in many deep vitrectomy procedures in which intraocular illumination is also required.

May DR; Dignam BJ

1983-08-01

83

Subcutaneous insulin infusion: change in basal infusion rate has no immediate effect on insulin absorption rate  

International Nuclear Information System (INIS)

[en] Eight insulin-dependent diabetic patients were simultaneously given subcutaneous infusions (1.12 IU/h each) of 125I-labeled Actrapid insulin in each side of the abdominal wall. After 24 h of infusion, the size of the infused insulin depots was measured by external counting for 5 h. The basal infusion rate was then doubled in one side and halved in the other for the next 4 h. Finally, 1.12 IU/h of insulin was given in both sides of the abdominal wall for an additional 3 h. The changes in the size of the depots were measured, and the absorption rates for each hour were calculated. During the first 5 h of infusion, the depot size was almost constant (approximately 5 IU) with an absorption rate that equaled the infusion rate. Doubling the infusion rate led to a significant increase in depot size, but the absorption rate remained unchanged for the first 3 h, and only thereafter was a significant increase seen. When the infusion rate was reduced to the initial 1.12 IU/h, the absorption rate remained elevated during the next 3 h. Correspondingly, when the infusion rate was decreased, the depot size also decreased, but the absorption rate remained unchanged for the first 3 h. The results show that a change in the basal insulin infusion rate does not lead to any immediate change in the insulin absorption rate. This should be considered when planning an insulin-infusion program that includes alteration(s) in the basal-rate setting

1986-01-01

84

Subcutaneous insulin infusion: change in basal infusion rate has no immediate effect on insulin absorption rate  

Energy Technology Data Exchange (ETDEWEB)

Eight insulin-dependent diabetic patients were simultaneously given subcutaneous infusions (1.12 IU/h each) of /sup 125/I-labeled Actrapid insulin in each side of the abdominal wall. After 24 h of infusion, the size of the infused insulin depots was measured by external counting for 5 h. The basal infusion rate was then doubled in one side and halved in the other for the next 4 h. Finally, 1.12 IU/h of insulin was given in both sides of the abdominal wall for an additional 3 h. The changes in the size of the depots were measured, and the absorption rates for each hour were calculated. During the first 5 h of infusion, the depot size was almost constant (approximately 5 IU) with an absorption rate that equaled the infusion rate. Doubling the infusion rate led to a significant increase in depot size, but the absorption rate remained unchanged for the first 3 h, and only thereafter was a significant increase seen. When the infusion rate was reduced to the initial 1.12 IU/h, the absorption rate remained elevated during the next 3 h. Correspondingly, when the infusion rate was decreased, the depot size also decreased, but the absorption rate remained unchanged for the first 3 h. The results show that a change in the basal insulin infusion rate does not lead to any immediate change in the insulin absorption rate. This should be considered when planning an insulin-infusion program that includes alteration(s) in the basal-rate setting.

Hildebrandt, P.; Birch, K.; Jensen, B.M.; Kuehl, C.

1986-11-01

85

Vocal fold submucosal infusion technique in phonomicrosurgery.  

UK PubMed Central (United Kingdom)

Phonomicrosurgery is optimized by maximally preserving the vocal fold's layered microstructure (laminae propriae). The technique of submucosal infusion of saline and epinephrine into the superficial lamina propria (SLP) was examined to delineate how, when, and why it was helpful toward this surgical goal. A retrospective review revealed that the submucosal infusion technique was used to enhance the surgery in 75 of 152 vocal fold procedures that were performed over the last 2 years. The vocal fold epithelium was noted to be adherent to the vocal ligament in 29 of the 75 cases: 19 from previous surgical scarring, 4 from cancer, 3 from sulcus vocalis, 2 from chronic hemorrhage, and 1 from radiotherapy. The submucosal infusion technique was most helpful when the vocal fold epithelium required resection and/or when extensive dissection in the SLP was necessary. The infusion enhanced the surgery by vasoconstriction of the microvasculature in the SLP, which improved visualization during cold-instrument tangential dissection. Improved visualization facilitated maximal preservation of the SLP, which is necessary for optimal pliability of the overlying epithelium. The infusion also improved the placement of incisions at the perimeter of benign, premalignant, and malignant lesions, and thereby helped preserve epithelium uninvolved by the disorder.

Kass ES; Hillman RE; Zeitels SM

1996-05-01

86

High-precision infusion pump and using method  

UK PubMed Central (United Kingdom)

The invention relates to a high-precision infusion pump and a using method thereof, belonging to the field of medical devices. The key is to always maintain accurate speed by carrying out the immediate implementation and the adjustment by a single-chip microcomputer according to a weight signal the pump is characterized in that: the single-chip microcomputer is arranged in the infusion pump, an upper transverse frame of a frame body is hung with a weight meter, the weight meter is hung with a liquid bottle, the infusion pump is arranged on a lower transverse frame of the frame body, the liquid bottle is inserted with one end of a soft tube, the other end of the soft tube is inserted with an input end of the infusion pump, an output end of the infusion pump is inserted with an infusion tube, and the output end of the weight signal of the weight meter is electrically connected with the single-chip microcomputer. The operation steps of the method are as follows: the infusion amount and the infusion time are input to the single-chip microcomputer according to the order of doctor by the high-precision infusion pump, the liquid bottle is hung on the weight meter, the soft tube is use for connecting the liquid bottle with the infusion pump, the infusion pump is started to allow liquid medicine to be flowed out of the infusion tube, then the infusion pump is closed, and the infusion pump is started to carry out the infusion after a needle of the infusion tube is punctured into a vein of a patient. The high-precision infusion pump is used for infusion of the patient. The operation is simple, and the self-weight of liquid is a control signal for carrying out the immediate implementation and adjustment and maintaining the infusion speed.

AIMIN MAO

87

A new venous infusion pathway monitoring system.  

Science.gov (United States)

A new infusion catheter pathway monitoring system employing linear integrated circuits and a low-power 8-bit single chip microcomputer has been developed for hospital and home use. The sensor consists of coaxial three-layer conductive tapes wrapped around the polyvinyl chloride infusion tube. The inner tape is the main electrode, which records an AC (alternating current) voltage induced on the patient's body by electrostatic coupling from the normal 100 volt, 60 Hz AC power line wiring field in the patient's room. The outside tape layer is a reference electrode to monitor the AC voltage around the main electrode. The center tape layer is connected to system ground and functions as a shield. The microcomputer calculates the ratio of the induced AC voltages recorded by the main and reference electrodes and if the ratio indicates a detached infusion, alerts the nursing station, via the nurse call system or low transmitting power mobile phone. PMID:18002453

Maki, Hiromichi; Yonezawa, Yoshiharu; Ogawa, Hidekuni; Ninomiya, Ishio; Sata, Koji; Hamada, Shingo; Caldwell, W Morton

2007-01-01

88

A new venous infusion pathway monitoring system.  

UK PubMed Central (United Kingdom)

A new infusion catheter pathway monitoring system employing linear integrated circuits and a low-power 8-bit single chip microcomputer has been developed for hospital and home use. The sensor consists of coaxial three-layer conductive tapes wrapped around the polyvinyl chloride infusion tube. The inner tape is the main electrode, which records an AC (alternating current) voltage induced on the patient's body by electrostatic coupling from the normal 100 volt, 60 Hz AC power line wiring field in the patient's room. The outside tape layer is a reference electrode to monitor the AC voltage around the main electrode. The center tape layer is connected to system ground and functions as a shield. The microcomputer calculates the ratio of the induced AC voltages recorded by the main and reference electrodes and if the ratio indicates a detached infusion, alerts the nursing station, via the nurse call system or low transmitting power mobile phone.

Maki H; Yonezawa Y; Ogawa H; Ninomiya I; Sata K; Hamada S; Caldwell WM

2007-01-01

89

High-tech homecare infusion therapies.  

Science.gov (United States)

Dramatic changes in health care delivery have created an increased reliance on ambulatory care. Adults and children increasingly are receiving infusions of intravascular medication or fluid in the home for a wide array of conditions. Several therapies have been adapted to the home, including chemotherapy, BRMs, TPN, blood components, anti-infectives, analgesics, inotropic agents, and investigational drugs. High-technology therapy in the home mandates safe and reliable vascular access to maximize positive outcomes, independence, and self-care; minimize costs and disruption of daily activities and work schedules; and enhance client and family adjustments and satisfaction. Currently, the four main VADs for vascular access are central venous catheters (CVCs), peripherally inserted central catheters (PICCs, implantable infusion ports, and external or implantable ambulatory infusion pumps. PMID:9855892

Bean, C A

1998-09-01

90

Image of Interest: Complications of intraosseous infusion.  

Directory of Open Access Journals (Sweden)

Full Text Available A 5-month-old child was admitted to the paediatric intensive care unit with status epilepticus and cardio-respiratory arrest. Due to difficulty with obtaining intravenous access, an intraosseous infusion was started in the left proximal tibia. This was discontinued after two days. On examination there was swelling of the left leg with minimal redness. The site of infusion did not show any abnormality. A radiograph of the left leg performed on the ninth day did not reveal any abnormalities. A repeat radiograph performed on the twentieth day is shown above (Panel).What is the diagnosis?Answer: refer to page 237

Ketan PANDE; Kylath George MAMMAN

2011-01-01

91

Muscle relaxation with an infusion of vecuronium.  

UK PubMed Central (United Kingdom)

Vecuronium was administered by a continuous intravenous infusion following a bolus dose of 0.1 mg kg-1 in 10 patients. Following recovery of twitch height to 10% of control, steady state dose requirement for maintaining a 90% block was attained in an average of 15.4 min. The average dose required was 0.083 mg kg-1 h-1 or 3.27 mg m-2 h-1. Large individual variations were observed but each patient required an approximately constant dose over periods up to 4.5 h. Recovery was prompt following cessation of infusion.

Mirakhur RK; Ferres CJ

1984-12-01

92

Rapid self-infusion of tap water.  

UK PubMed Central (United Kingdom)

Intravenous self-infusion of tap water has never been reported in the literature.  We present a 24-year-old healthy man who self-administered 2.5 L of tap water over 2 hours and developed acute illness including fever, change of mental status, acute hemolysis, low-grade disseminated intravascular coagulation, and acute kidney injury.  

Chaudhary S; Kashani K; Williams AW; El-Zoghby ZM; Albright RC; Qian Q

2013-03-01

93

NON-MAGNETIC MEDICAL INFUSION DEVICE  

UK PubMed Central (United Kingdom)

Liquid infusion apparatus includes non-magnetic materials in a pumping structure and drive motor therefore, and in a controller that supplies drive signals to the motor to facilitate convenient operation in intense magnetic fields without distorting the magnetic fields and without radiating objectionable radio-frequency interference.

SUSI ROGER E

94

Intravenous infusions in chronic pain management.  

UK PubMed Central (United Kingdom)

In the United States, millions of Americans are affected by chronic pain, which adds heavily to national rates of morbidity, mortality, and disability, with an ever-increasing prevalence. According to a 2011 report titled Relieving Pain in America: A Blueprint for Transforming Prevention, Care, Education, and Research by the Institute of Medicine of the National Academies, pain not only exacts its toll on people's lives but also on the economy with an estimated annual economic cost of at least $560 - 635 billion in health care costs and the cost of lost productivity attributed to chronic pain. Intravenous infusions of certain pharmacologic agents have been known to provide substantial pain relief in patients with various chronic painful conditions. Some of these infusions are better, and although not necessarily the first therapeutic choice, have been widely used and extensively studied. The others show promise, however are in need of further investigations. This article will focus on non-opiate intravenous infusions that have been utilized for chronic painful disorders such as fibromyalgia, neuropathic pain, phantom limb pain, post-herpetic neuralgia, complex regional pain syndromes (CRPS), diabetic neuropathy, and central pain related to stroke or spinal cord injuries. The management of patients with chronic pain conditions is challenging and continues to evolve as new treatment modalities are explored and tested. The following intravenous infusions used to treat the aforementioned chronic pain conditions will be reviewed: lidocaine, ketamine, phentolamine, dexmedetomidine, and bisphosphonates. This overview is intended to familiarize the practitioner with the variety of infusions for patients with chronic pain. It will not, however, be able to provide guidelines for their use due to the lack of sufficient evidence.

Kosharskyy B; Almonte W; Shaparin N; Pappagallo M; Smith H

2013-05-01

95

Pharmacokinetics of continuous subcutaneous insulin infusion  

DEFF Research Database (Denmark)

One of the reasons for the variability of blood glucose regulation in Type 1 (insulin-dependent) diabetic patients is the huge variation in subcutaneous absorption of intermediate-acting insulin. We have investigated the variation in insulin absorption during continuous subcutaneous insulin infusion in eight such patients. The content of insulin in the subcutaneous tissue was measured using 125I-labelled insulin. The concentration of free serum insulin and blood glucose was followed from 1 h before and from 7 h after breakfast on two consecutive days. The amount of insulin absorbed during 24 h differed in all cases by less than 3% from the daily insulin dose given by the pumps. Mean insulin absorption rates and mean free insulin concentration showed peak values 30-90 min after meal bolus injections; this was sufficient to maintain near-normal blood glucose. Mean free serum insulin correlated strongly with disappearance of insulin from the subcutaneous tissue (r = 0.98). From the insulin absorption rates and free insulin concentrations during basal constant insulin infusion, the half-time of serum insulin was calculated as 6 min. Compared with the known large variability in the absorption of intermediate-acting insulin, continuous subcutaneous insulin infusion offers a precise and reproducible way of insulin administration resulting in post-prandial serum insulin peaks sufficient to maintain near-normal blood glucose levels. The half-time of serum insulin during subcutaneous infusion corresponds to values for intravenous infusion given in the literature, indicating that local degradation of insulin in subcutaneous tissue is of minor importance.

Lauritzen, Torsten; Pramming, S

1983-01-01

96

Intravenous infusions in chronic pain management.  

Science.gov (United States)

In the United States, millions of Americans are affected by chronic pain, which adds heavily to national rates of morbidity, mortality, and disability, with an ever-increasing prevalence. According to a 2011 report titled Relieving Pain in America: A Blueprint for Transforming Prevention, Care, Education, and Research by the Institute of Medicine of the National Academies, pain not only exacts its toll on people's lives but also on the economy with an estimated annual economic cost of at least $560 - 635 billion in health care costs and the cost of lost productivity attributed to chronic pain. Intravenous infusions of certain pharmacologic agents have been known to provide substantial pain relief in patients with various chronic painful conditions. Some of these infusions are better, and although not necessarily the first therapeutic choice, have been widely used and extensively studied. The others show promise, however are in need of further investigations. This article will focus on non-opiate intravenous infusions that have been utilized for chronic painful disorders such as fibromyalgia, neuropathic pain, phantom limb pain, post-herpetic neuralgia, complex regional pain syndromes (CRPS), diabetic neuropathy, and central pain related to stroke or spinal cord injuries. The management of patients with chronic pain conditions is challenging and continues to evolve as new treatment modalities are explored and tested. The following intravenous infusions used to treat the aforementioned chronic pain conditions will be reviewed: lidocaine, ketamine, phentolamine, dexmedetomidine, and bisphosphonates. This overview is intended to familiarize the practitioner with the variety of infusions for patients with chronic pain. It will not, however, be able to provide guidelines for their use due to the lack of sufficient evidence. PMID:23703410

Kosharskyy, Boleslav; Almonte, Wilson; Shaparin, Naum; Pappagallo, Marco; Smith, Howard

97

Infusion MR arteriography during hepatic arterial infusion chemotherapy. Evaluation of clinical usefulness  

International Nuclear Information System (INIS)

We developed a new method of infusion MR arteriography (IMRA) via an implantable port system using an infusion pump for the evaluation of drug distribution during hepatic arterial infusion chemotherapy. The purposes of this study were to optimize the method and evaluate its clinical usefulness. We used 3D-T1 turbo field echo (TFE) as the most suitable sequence for IMRA according to the results of a phantom model experiment. We examined 33 cases of liver cancer that had been treated by arterial infusion chemotherapy via the port system. The following investigations were performed: degree of tumor enhancement, intra- and extra- hepatic perfusion abnormality, and related toxicity. The evaluation of images was performed separately by two radiologists. IMRA provided good images of contrast enhancement, to reveal the perfusion patterns. The treatment response rate in the tumor group with well enhancement was higher than that of the group with poor enhancement (p

2003-01-01

98

75 FR 21641 - Infusion Pumps; Public Meeting; Request for Comments  

Science.gov (United States)

...Docket No. FDA-2010-N-0204] Infusion Pumps; Public Meeting; Request for Comments...public meeting regarding external infusion pumps. The purpose of the meeting is to inform...problems associated with external infusion pump use, to help the agency identify...

2010-04-26

99

[Levodopa intestinal infusion therapy in Parkinson's disease].  

UK PubMed Central (United Kingdom)

Medical treatment of advanced Parkinson disease complicated with fluctuations and dyskinesias remains difficult or in some patients totally ineffective. Recently, new methods were introduced to manage those problems: deep brain stimulation, subcutaneous apomorphine infusion and the Duodopa system for intrajejunal continuous delivery of gel containing levo-dopa/carbidopa (through percutaneous gastrostomy). This last method was proven to be very effective in reducing the fluctuations of levodopa plasma levels and furthermore in reducing the off periods and dyskinesias. The Duodopa system is used in patients with contraindications to deep brain stimulation or apomorphine infusions. According to recently published studies, it may also be more effective in reducing motor complications than other methods. The authors present the current knowledge on the Duodopa system, its effectiveness (also in relationship to other methods, specially deep brain stimulation and apomorphine) and possible complications (mostly due to gastric tube failures) along with the indications and contraindications.

S?awek J; Bogucki A

2010-07-01

100

[Levodopa intestinal infusion therapy in Parkinson's disease].  

Science.gov (United States)

Medical treatment of advanced Parkinson disease complicated with fluctuations and dyskinesias remains difficult or in some patients totally ineffective. Recently, new methods were introduced to manage those problems: deep brain stimulation, subcutaneous apomorphine infusion and the Duodopa system for intrajejunal continuous delivery of gel containing levo-dopa/carbidopa (through percutaneous gastrostomy). This last method was proven to be very effective in reducing the fluctuations of levodopa plasma levels and furthermore in reducing the off periods and dyskinesias. The Duodopa system is used in patients with contraindications to deep brain stimulation or apomorphine infusions. According to recently published studies, it may also be more effective in reducing motor complications than other methods. The authors present the current knowledge on the Duodopa system, its effectiveness (also in relationship to other methods, specially deep brain stimulation and apomorphine) and possible complications (mostly due to gastric tube failures) along with the indications and contraindications. PMID:20827613

S?awek, Jaros?aw; Bogucki, Andrzej

 
 
 
 
101

Impact of priming the infusion system on the performance of target-controlled infusion of remifentanil.  

UK PubMed Central (United Kingdom)

BACKGROUND: The start-up behavior of syringe and syringe pump is known to be one of the causes of inaccurate intravenous infusion. This study evaluated the method of priming the infusion system (PRIMING), and its impact on the target-controlled infusion (TCI) of two remifentanil diluents. METHODS: PRIMING was performed using an evacuation of 2.0 ml to the atmosphere prior to TCI. Forty-eight TCI, using 50 µg/ml (Remi50) or 20 µg/ml (Remi20) of diluents, were performed targeting 4.0 ng/ml of effect-site concentration (Ceff), with PRIMING or not. The gravimetrical measurements of the delivered infusates reproduced actual Ceff. The bolus amount and time to reach 95% target were compared. RESULTS: Without PRIMING, Remi50 infused less bolus (43 ± 23 %) than Remi20 (19 ± 9 %) (P = 0.003), and showed more delayed increase of Ceff (11.2 ± 4.0 min) than Remi20 (7.4 ± 0.4 min) (P = 0.028). However, PRIMING significantly decreased the deficit of the bolus (2 ± 1%), as well as the delay of the increase of Ceff in Remi50 (1.2 ± 0.2 min) (both P < 0.001). In addition, with PRIMING, the start-up bolus showed minimal difference to the nominal bolus (1 and 2%), and Ceff were increased to 4.0 ± 0.1 ng/ml at the expected time of peak effect, irrespective of the diluents. CONCLUSIONS: Proper operation of the syringe pump used in the priming of the syringe may be helpful in reduction of the inaccuracy of TCI, particularly during the early phase of infusion, or the infusion of a more concentrated diluent.

Kim JY; Moon BK; Lee JH; Jo YY; Min SK

2013-05-01

102

Superselective arterial infusion and concomitant radiotherapy  

Energy Technology Data Exchange (ETDEWEB)

Superselective arterial infusion for patients with advanced head and neck cancer has been increasingly applied in Japan. We analyzed our experiences and evaluated the efficacy and safety of this treatment. Through October 1999 to March 2002, 29 patients, ranging in age between 33 and 71 years (median 52 years), received superselective intra-arterial infusion therapy of cisplatin (100-120 mg/m{sup 2}/week) with simultaneous intravenous infusion of thiosulfate for neutralizing cisplatin toxicity, and conventional concomitant extrabeam radiotherapy (65 Gy/26 f/6.5 weeks). Four patients were diagnosed with stage III and 25 with stage IV. Thirteen patients were considered contraindicated for surgery, and the other 16 patients rejected radical surgery. Primary tumor sites included paranasal sinus (11 patients), hypopharynx (7), oropharynx (6), oral cavity (4), and parotid gland (1). During the median follow-up period of 20 months, there was no apparent recurrence in 14 (48.3%) of 29 patients. Eleven (37.9%) patients died of disease, and three (10.3%) were alive with disease. In twenty-one patients (72.4%) the primary lesions were well-controlled. Acute toxic effects were moderate, and severe toxic events occurred in four cases, namely, methicillin-resistant staphylococcus aureus (MRSA) pneumonia, sepsis, tetraplasia, and osteoradionecrosis. We confirmed the effectiveness and safety of superselective arterial infusion and concomitant radiotherapy. Furthermore, we must establish the optimal procedures and schedule, as well as the indications for this treatment. This treatment protocol may improve the prognosis of patients with unresectable disease and patients rejecting surgical treatment. Further study in this particular area is needed. (author)

Homma, Akihiro; Suzuki, Fumiyuki; Inuyama, Yukio; Fukuda, Satoshi [Hokkaido Univ., Sapporo (Japan). School of Medicine

2003-05-01

103

Superselective arterial infusion and concomitant radiotherapy  

International Nuclear Information System (INIS)

[en] Superselective arterial infusion for patients with advanced head and neck cancer has been increasingly applied in Japan. We analyzed our experiences and evaluated the efficacy and safety of this treatment. Through October 1999 to March 2002, 29 patients, ranging in age between 33 and 71 years (median 52 years), received superselective intra-arterial infusion therapy of cisplatin (100-120 mg/m2/week) with simultaneous intravenous infusion of thiosulfate for neutralizing cisplatin toxicity, and conventional concomitant extrabeam radiotherapy (65 Gy/26 f/6.5 weeks). Four patients were diagnosed with stage III and 25 with stage IV. Thirteen patients were considered contraindicated for surgery, and the other 16 patients rejected radical surgery. Primary tumor sites included paranasal sinus (11 patients), hypopharynx (7), oropharynx (6), oral cavity (4), and parotid gland (1). During the median follow-up period of 20 months, there was no apparent recurrence in 14 (48.3%) of 29 patients. Eleven (37.9%) patients died of disease, and three (10.3%) were alive with disease. In twenty-one patients (72.4%) the primary lesions were well-controlled. Acute toxic effects were moderate, and severe toxic events occurred in four cases, namely, methicillin-resistant staphylococcus aureus (MRSA) pneumonia, sepsis, tetraplasia, and osteoradionecrosis. We confirmed the effectiveness and safety of superselective arterial infusion and concomitant radiotherapy. Furthermore, we must establish the optimal procedures and schedule, as well as the indications for this treatment. This treatment protocol may improve the prognosis of patients with unresectable disease and patients rejecting surgical treatment. Further study in this particular area is needed. (author)

2003-01-01

104

Pulmonary Embolysm After Cesarean Section  

Directory of Open Access Journals (Sweden)

Full Text Available Pregnancy is a physiologic state with an increased risk for thromboembolic complications. Tachypnea and respiratory distress was evident in a 36- yearold female patient in the postoperative third hour after an elective cesarean section in the 38. week of pregnancy. Thoracic tomography revealed pulmonary embolism, the patient was admitted to the intensive care unit and tranecsamic acid infusion was started. Paradoxical septal motion and a 4x1 cm hpyerechogenic mobile mass on the right atrium attached to the inferior wall was apparent in the echocardiographic assessment. Thrombolytic infusion therapy was started due to the worsening of the patient's respiratory distress and hemodynamic state but was withdrawn due to the active bleeding from the vagina and the operation site. Bleeding was controlled by erythrocyte and thrombocyte suspensions, freshly drawn blood, and fresh frozen plasma. Echocardiographic control revealed lysis of the thrombus in the right atrium and the patient was moved to the obstetrics ward on the 4. day.

Sevtap HEKIMOGLU SAHIN; Dilek MEMIS; Sermin SEKER; Ozlem SARITABAK; Tarik YANDIM

2007-01-01

105

Safe infusion apparatus and preparation method thereof  

UK PubMed Central (United Kingdom)

The invention provides a safe infusion apparatus and a preparation method thereof. The infusion apparatus comprises a dropping funnel and a perfusion tube wherein, both the dropping funnel and the perfusion tube are made of polyurethane/ polyvinyl chloride double-layer composite material the inner surface layer of the dropping funnel made of the polyurethane/ polyvinyl chloride double-layer composite material is a polyurethane layer, and the outer surface layer thereof is a polyvinyl chloride layer. The polyurethane/ polyvinyl chloride double-layer composite material is prepared by a co-extrusion blow molding method, and the perfusion tube made of the polyurethane/ polyvinyl chloride double-layer composite material is prepared by a co-extrusion method. The safe infusion apparatus can avoid the defect that the polyvinyl chloride perfusion tube absorbs micromolecules such as medicine, plasticizer and the like to pollute liquid medicine, and has the advantages of excellent mechanical property, easy bonding and assembling as well as low raw material cost.

SHIFANG LUAN; JINGHUA YIN; HENGCHONG SHI

106

Intelligent infusion device based on wireless network  

UK PubMed Central (United Kingdom)

The invention discloses an intelligent infusion device based on a wireless network, comprising a dropping funnel (20), a flexible pipe (8), a dripping speed monitoring device (1), a display screen (2), a wireless transmit-receive device (3), a dripping speed controller (4), a microcontroller MCU (5) and a movable type infusion controller (6), wherein the flexible pipe (8) is communicated with both ends of the dropping funnel (20) the dripping speed monitoring device (1), the display screen (2) and the microcontroller MCU (5) are integrated on a circuit board (90), and the circuit board (90) is arranged on the dropping funnel (20) and the wireless transmit-receive device (3) and the dripping speed controller (4) are arranged on the flexible pipe (8) positioned below the dropping funnel (20) and are respectively connected with the microcontroller MCU (5) arranged on the circuit board (90) through lead wires. The invention realizes the whole-course intelligent control in the infusion process, so that medical workers can more conveniently and comprehensively know the information of patients in the treatment process.

ZHIYU QIAN; BEN QU; JIANHUA ZHANG; YUE PAN

107

Irreversible sediment formation in green tea infusions.  

UK PubMed Central (United Kingdom)

The formation of irreversible tea sediment (IRS) and its chemical components in green tea infusions were investigated. The results showed that the amounts of IRS in the green tea infusions from various tea cultivars ranged from 0.10 to 1.47 mg/mL. The amount of IRS was influenced remarkably by the chemical components in the green tea infusion. Principal component analysis and regression analysis indicated that gallated catechins, Mn, Ca, caffeine, Na, and (-)-gallocatechin gallate (GCG) were the principal components. IRS (mg/mL) = -4.226 + 0.275 gallated catechins + 79.551 Na + 7.321 Mn + 21.055 Ca + 0.513 caffeine - 0.129 GCG (R2 = 0.697). The contents of the main chemical components in the reversible tea sediment (RTS) and IRS were markedly different, especially the minerals. Large amount of minerals participated in the formation of irreversible green tea sediment. The amount of IRS increased with the extraction temperature.

Xu YQ; Chen GS; Wang QS; Yuan HB; Feng CH; Yin JF

2012-03-01

108

Technical risks with subcutaneous insulin infusion.  

UK PubMed Central (United Kingdom)

The popularity of continuous subcutaneous insulin infusion (CSII), as a way for achieving long term strict glycaemic control in diabetic patients, has increased over the last ten years. Most reports on technical faults, often leading to metabolic emergencies, mainly ketoacidosis, have been published in the 1980s. Obstruction of infusion set and infection of infusion site are the most frequent events. Insulin precipitation or aggregation is thought to be one of the precipitating factors. Few data are available about failures of the pump itself. We report our experience of pump malfunctions recorded between 2001 and 2004 in 376 pumps used by patients treated with CSII therapy in Brittany. Recent studies indicate a decrease of metabolic complication frequency during CSII. This suggests technical improvements and/or a greater experience of physicians in selecting and educating patients. We report instructions for monitoring insulin pump therapy that should be included in a formal educational program for pump users. Clinical studies using newly available devices should reassess technical risks associated with CSII.

Guilhem I; Leguerrier AM; Lecordier F; Poirier JY; Maugendre D

2006-06-01

109

Serial infusions of low-dose ketamine for major depression.  

UK PubMed Central (United Kingdom)

BACKGROUND: Single infusions of ketamine have been used successfully to achieve improvement in depressed patients. Side effects during the infusions have been common. It is not known whether serial infusions or lower infusion rates result in greater efficacy. METHODS: Ten depressed patients were treated with twice weekly ketamine infusions of ketamine 0.5 mg/kg administered over 100 min until either remission was achieved or four infusions were given. Side effects were assessed with the Young Mania Rating Scale (YMRS) and the Brief Psychiatric Rating Scale (BPRS). Patients were followed naturalistically at weekly intervals for four weeks after completion of the infusions. RESULTS: Five of 10 patients achieved remission status. There were no significant increases on the BPRS or YMRS. Two of the remitting patients sustained their improvement throughout the four week follow-up period. CONCLUSIONS: Ketamine infusions at a lower rate than previously reported have demonstrated similar efficacy and excellent tolerability and may be more practically available for routine clinical care. Serial ketamine infusions appear to be more effective than a single infusion. Further research to test relapse prevention strategies with continuation ketamine infusions is indicated.

Rasmussen KG; Lineberry TW; Galardy CW; Kung S; Lapid MI; Palmer BA; Ritter MJ; Schak KM; Sola CL; Hanson AJ; Frye MA

2013-05-01

110

[Infusion MR arteriography during hepatic arterial infusion chemotherapy: evaluation of clinical usefulness].  

UK PubMed Central (United Kingdom)

PURPOSE: We developed a new method of infusion MR arteriography (IMRA) via an implantable port system using an infusion pump for the evaluation of drug distribution during hepatic arterial infusion chemotherapy. The purposes of this study were to optimize the method and evaluate its clinical usefulness. MATERIALS AND METHODS: We used 3D-T1 TFE as the most suitable sequence for IMRA according to the results of a phantom model experiment. We examined 33 cases of liver cancer that had been treated by arterial infusion chemotherapy via the port system. The following investigations were performed: degree of tumor enhancement, intra- and extrahepatic perfusion abnormality, and related toxicity. The evaluation of images was performed separately by two radiologists. RESULTS: IMRA provided good images of contrast enhancement, to reveal the perfusion patterns. The treatment response rate in the tumor group with well enhancement was higher than that of the group with poor enhancement (p < 0.0001). Extrahepatic perfusion was well visualized and was correlated with toxicity (p < 0.0001). CONCLUSION: IMRA is a useful method to evaluate drug perfusion for the optimization of arterial infusion chemotherapy.

Uchino M; Takizawa K

2003-11-01

111

Evaluation of Talbot's Safety Zone of Infusion Volume and Osmolality in Infusion Therapy for Decompensated Liver Cirrhosis  

Directory of Open Access Journals (Sweden)

Full Text Available Problems with infusion therapy for correcting fluid and sodium imbalance in decompensated liver cirrhosis (DLC) were investigated by establishing the safety zone of Talbot et al. for parenteral fluid therapy in 4 DLC patients infused with over 900 ml of fluid each day for at least 9 days. The safety zone was different in each case. The safe infusion volume decreased and the safe electrolyte concentration shifted to a lower osmolality when there was ascites with renal failure than ascites without renal failure. Infusion therapy was performed without deterioration of the water and sodium balance in those patients whose infusion volume and fluid osmolality were in the safety zone. In contrast, ascites retention increased and peripheral edema appeared in patients whose infusion volume and osmolality were out of the safety zone. Therefore, the safety zone should be determined repeatedly during infusion therapy.

Yuasa,Shiro; Itoshima,Tatsuya; Ono,Ryosaku; Nagashima,Hideo

1985-01-01

112

Comparison of 20-, 23-, and 25-gauge air infusion forces.  

UK PubMed Central (United Kingdom)

PURPOSE: To determine and compare 20-, 23-, and 25-gauge retinal infusion air jet impact pressure (force per unit area) in an experimental setting. METHODS: Experimental laboratory investigation. Infusion cannulas were connected to a compressed air system. A controlled valve mechanism was used to obtain increasing levels of infusion pressure. Each infusion tube was positioned in front of a manual transducer to measure force. Impact pressure was calculated using known formulas in fluid dynamics. RESULTS: The 20-gauge infusion jet showed similar impact pressure values compared with the 23-gauge infusion jet. Both showed higher levels than the 25-gauge infusion jet. This was because of the smaller jet force for the 25-gauge system. CONCLUSION: In this experimental study, both the 23- and the 20-gauge air infusion jet showed higher impact pressure values compared with the 25-gauge air infusion jet. This could be of concern regarding air infusion during 23-gauge vitrectomy since retinal damage has been shown in standard-gauge surgeries.

Machado LM; Magalhães O Jr; Maia M; Rodrigues EB; Farah ME; Ismail KA; Molon L; Oliveira DA

2011-11-01

113

Dispensing Fluid from an Infusion Pump System  

UK PubMed Central (United Kingdom)

Some embodiments of a medical infusion pump system include a pump device having a cap device that mates with a pump housing to retain a medicine cartridge therein. In addition to retaining the medicine cartridge in the pump housing, the cap device may perform a number of preparatory functions or safety functions. In addition or in the alternative, some embodiments of the pump device may include a drive system that advances a piston rod to dispense medicine to the patient in a safe and energy efficient manner.

CAUSEY JAMES; KIRSCHEN TODD; WENGER MITCHELL; FRIEDMAN STEVEN; COLTON JOSHUA; CHRISTENSEN KELD SLOTH

114

INTRAOSSEOUS INFUSION: RECENT ADVANCE IN DRUG DELIVERY  

Directory of Open Access Journals (Sweden)

Full Text Available Intraosseus infusion offers an attractive alternative to conventional drug delivery method of injection. It is theprocess of injection directly into the marrow of the bone. It is used to provide fluids and medication, when an IV linecannot be used. The needle is injected through the bone's hard cortex and into the soft marrow interior. Often theantero-medial aspect of the tibia is used as it lies just under the skin and can easily be palpated and located. Anterioraspect of the femur the superior iliac crest and the head of the humerus are other sites that can be used.

Rohan d. zade [1]* Mitkare s.s [2] A.V.Yadav [3] Gadhve S.V [1

2011-01-01

115

Rat enterohepatic circulation and intestinal distribution of enterally infused thyroid hormones  

Energy Technology Data Exchange (ETDEWEB)

The enterohepatic circulation (recycling), intestinal (gut) distribution, metabolism, and excretion of enterally infused thyroid hormones were studied in the intact rat under approximately normal physiological steady state conditions. Rats with 7-day osmotic minipumps implanted ip received constant intraduodenal infusions to steady state of very small trace doses of either 125I-labeled T3 (T3*) or T4 (T4*). Enterohepatic and other pathways remained open to normal function, and in particular, there was no biliary diversion or ligation. Complete feces and urine were collected daily, to assess daily distributions of radioactivity and establishment of the steady state, which occurred by day 3. On day 7, rats were anesthetized, blood was sampled, whole intestine and minipumps were removed, and the gut was separated into six segments. Fecal samples and the contents of each gut section were homogenized, ethanol extracted, evaporated, and reconstituted in NaOH for quantitative aqueous chromatography along with infusate, urine, and plasma samples, on Sephadex G-25 columns. No T3* or T4* was found in urine, but feces contained 39% of the T3* infused and 36% of the T4* infused in steady state. Statistically significant amounts of both T3* and T4* in systemic plasma on day 7 clearly indicated absorption of the hormones from the intestine, distinctly demonstrating an enterohepatic circulation of T3 and T4 under experimental conditions closely approximating the physiological steady state. This also establishes the intestine (with its contents) as an exchangeable hormone pool, physiologically internal to the system regulating thyroid hormones and their distribution. Gut contents contained 52 times more T3* and 4.34 times more T4* than corresponding plasma pools in steady state.

DiStefano, J.J. III; Sternlicht, M.; Harris, D.R.

1988-11-01

116

Clinical applications of continuous infusion chemotherapy ahd concomitant radiation therapy  

International Nuclear Information System (INIS)

[en] This book presents information on the following topics: theoretical basis and clinical applications of 5-FU as a radiosensitizer; treatment of hepatic metastases from gastro intestingal primaries with split course radiation therapy; combined modality therapy with 5-FU, Mitomycin-C and radiation therapy for sqamous cell cancers; treatment of bladder carcinoma with concomitant infusion chemotherapy and irradiation; a treatment of invasiv bladder cancer by the XRT/5FU protocol; concomitant radiation therapy and doxorubicin by continuous infusion in advanced malignancies; cis platin by continuous infusion with concurrent radiation therapy in malignant tumors; combination of radiation with concomitant continuous adriamycin infusion in a patient with partially excised pleomorphic soft tissue sarcoma of the lower extremeity; treatment of recurrent carcinoma of the paranasal sinuses using concomitant infusion cis-platinum and radiation therapy; hepatic artery infusion for hepatic metastases in combination with hepatic resection and hepatic radiation; study of simultaneous radiation therapy, continuous infusion, 5FU and bolus mitomycin-C; cancer of the esophagus; continuous infusion VP-16, bolus cis-platinum and simultaneous radiation therapy as salvage therapy in small cell bronchogenic carcinoma; and concomitant radiation, mitomycin-C and 5-FU infusion in gastro intestinal cancer

1986-01-01

117

Clinical applications of continuous infusion chemotherapy ahd concomitant radiation therapy  

Energy Technology Data Exchange (ETDEWEB)

This book presents information on the following topics: theoretical basis and clinical applications of 5-FU as a radiosensitizer; treatment of hepatic metastases from gastro intestingal primaries with split course radiation therapy; combined modality therapy with 5-FU, Mitomycin-C and radiation therapy for sqamous cell cancers; treatment of bladder carcinoma with concomitant infusion chemotherapy and irradiation; a treatment of invasiv bladder cancer by the XRT/5FU protocol; concomitant radiation therapy and doxorubicin by continuous infusion in advanced malignancies; cis platin by continuous infusion with concurrent radiation therapy in malignant tumors; combination of radiation with concomitant continuous adriamycin infusion in a patient with partially excised pleomorphic soft tissue sarcoma of the lower extremeity; treatment of recurrent carcinoma of the paranasal sinuses using concomitant infusion cis-platinum and radiation therapy; hepatic artery infusion for hepatic metastases in combination with hepatic resection and hepatic radiation; study of simultaneous radiation therapy, continuous infusion, 5FU and bolus mitomycin-C; cancer of the esophagus; continuous infusion VP-16, bolus cis-platinum and simultaneous radiation therapy as salvage therapy in small cell bronchogenic carcinoma; and concomitant radiation, mitomycin-C and 5-FU infusion in gastro intestinal cancer.

Rosenthal, C.J.; Rotman, M.

1986-01-01

118

Adenosine infusion increases plasma levels of VEGF in humans  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Many in vitro studies have shown that adenosine (Ado) can induce vascular endothelial growth factor (VEGF) mRNA and protein expression and stimulate endothelial proliferation. In the present study, we seek to determine whether Ado can increase circulating levels of VEGF protein in the intact human. Methods Five outpatients 49.3 ± 6.7 years of age and weighing 88.2 ± 8.5 kg were selected. They were given a 6 min intravenous infusion of Ado (0.14 mg kg-1 min-1) in conjunction with sestamibi myocardial perfusion scans. Mean blood pressure (MBP, calculated from systolic and diastolic values) and heart rate (HR) were determined before Ado infusion and every 2 min for the next 10 min. Plasma VEGF concentrations (ELISA) were determined immediately before Ado infusion and 1 h, 2 h, and 8 h after the infusion. Results Plasma VEGF concentration averaged 20.3 ± 2.0 pg ml-1 prior to Ado infusion, and increased to 62.7 ± 18.1 pg ml-1 at 1 h post- infusion (p -1). MBP averaged 116 ± 7 mmHg and heart rate averaged 70 ± 7 prior to Ado infusion. MBP decreased by a maximum of ~22% and HR increased by a maximum of ~17% during the infusion. Conclusion We conclude from these preliminary findings that intravenous infusion of adenosine can increase plasma levels of VEGF in humans.

Adair Thomas H; Cotten Reid; Gu Jian-Wei; Pryor Janelle S; Bennett Kenneth R; McMullan Michael R; McDonnell Preston; Montani Jean-Pierre

2005-01-01

119

Quantitative evaluation of valvular regurgitation by 133Xenon infusion  

International Nuclear Information System (INIS)

[en] Mitral and aortic regurgitation was evaluated by X-ray, dye dilution bolus, and 133Xenon infusion methods in 24 patients with mitral, aortic or both valve lesions. Good reproducibility was found using the 133Xenon infusion method. The regurgitant fraction estimated by 133Xenon constant infusion method correlates well with the results of the dye dilution method in mitral regurgitation as well as in aortic regurgitation. The 133Xenon infusion method is well-suited for quantitative evaluation of mitral and aortic regurgitation. For its simplicity, it is therefore recommended for further clinical evaluation in pharmacodynamic and preoperative studies. (author)

1983-01-01

120

Warmed intravenous infusion for controlling intraoperative hypothermia.  

UK PubMed Central (United Kingdom)

OBJECTIVE: to verify the effectiveness of warmed intravenous infusion for hypothermia prevention in patients during the intraoperative period. METHOD: experimental, comparative, field, prospective and quantitative study undertaken at a federal public hospital. The sample was composed of 60 adults, included based on the criteria of axillary temperature between 36ºC and 37.1ºC and surgical abdominal access, divided into control and experimental groups, using the systematic probability sampling technique. RESULTS: 22 patients (73.4%) from both groups left the operating room with hypothermia, that is, with temperatures below 36ºC (p=1.0000). The operating room temperature when patients arrived and patients' temperature when they arrived at the operating room were statistically significant to affect the occurrence of hypothermia. CONCLUSION: the planning and implementation of nursing interventions carried out by baccalaureate nurses are essential for preventing hypothermia and maintaining perioperative normothermia.

Mattia AL; Barbosa MH; Freitas JP Filho; Rocha AD; Pereira NH

2013-06-01

 
 
 
 
121

Iron infusion and deposition in the kidney.  

UK PubMed Central (United Kingdom)

BACKGROUND: Parenteral iron therapy is the mainstay of treating iron deficiency anemia in chronic kidney disease (CKD) patients. METHODS: Retrospective case study of iron staining of renal tissues in 2 CKD patients who had received intravenous iron prior to the renal biopsy. RESULTS: Following the infusion of ferumoxytol, iron staining of renal biopsy demonstrated blue curvilinear deposition of iron in the tissue macrophages (histocytes) and interstitium of the kidney. Renal iron deposition was not observed in a patient administered intravenous iron dextran. CONCLUSION: We postulate that the higher molecular weight of ferumoxytol and different carbohydrate components may lead to deposition and trapping of the ironcarbohydrate complexes in the reticuloendothelial system of the kidney. Potential renal toxicity from iron induced oxidant stress, especially in patients with underlying chronic kidney disease, merits further investigation.

Tolouian R; Rajabi B; Boman D; Bilbao J; Gupta A

2013-03-01

122

Augmenting Information Retrieval by Knowledge Infusion  

UK PubMed Central (United Kingdom)

WiseWare is an operational knowledge-basedsystem providing support for help desk analysts,users in Information Technology departments andchannel partners [Delic and Lahaix, 1998]. AWiseWare document is an entity containinghuman readable knowledge expressed in freeform English text. Documents are evaluated andannotated for complexity, quality, usefulness andage, etc. The retrieval of documents relevant tosome query can be augmented by the infusion ofsome domain knowledge. This knowledgeinfusion can take place at one or both of twodistinct places in the retrieval process:. before the search, knowledge of a user'shabits, preferences and query history, etc. canbe used to modify a query. after the search, knowledge of a user'spreferences, skill level and viewing history,etc. can be combined with knowledge of theretrieved documents' complexity, quality, ageand source, etc. to rank and sort the results ina more relevant manner.This paper investigate...

Jeff Riley; Kemal A. Delic

123

Winged infusion apparatus for patient implantable access ports  

UK PubMed Central (United Kingdom)

There is disclosed a winged infusion apparatus for use with patient implantable access ports. Essentially, the apparatus includes a composite disc housing which is circular in configuration and has integrally formed therewith two winged sections which overlie arcuate apertures in the sides of the disc. A cannula is embedded within the internal body of the disc, and via a right angle bend the cannula emanates from the bottom surface of the disc at a central location. The winged members are operable so that they can be grasped by a user and placed in an upright position via integral hinges associated with each winged member. In this manner the user can then insert the cannula into an axis port which is implanted in a suitable body cavity of a patient and which has an output aperture on the patient's skin. By utilizing the device and due to the fact that the needle is centrally located and based on the position of the winged members, the entire unit has an extremely uniform profile whereby once the winged members are utilized in an upright position as manipulated by the fingers of a practitioner, they spring back so that they are flush with the top surface of the disc. Once the cannula is emplaced into the access port of the patient, the entire unit is taped by means of a suitable surgical tape onto the skin of the patient to thereby hold the entire unit in a rigid and fixed position.

MARCUS JOEL

124

Carmustine infusion reactions are more common with rapid administration.  

UK PubMed Central (United Kingdom)

PURPOSE: Carmustine is a nitrosurea alkylating agent predominantly used at Peter MacCallum Cancer Centre as part of the autologous stem cell transplant induction regimens Stanford BCNU and BEAM. Acute infusion reactions were anecdotally reported to be higher than the reported rates of 10%, and it was suggested that the rate of infusion being employed was excessive. Some references suggest maximum infusion rates of 3 mg/m(2)/min for carmustine, a rate which is exceeded in the 2-h infusions used for Stanford BCNU, but not with BEAM. METHODS: A retrospective audit was conducted in 64 patients (57 Stanford BCNU, 7 BEAM) who had received these regimens between January 2009 and November 2010. RESULTS: Rates of infusion reaction to carmustine were higher than literature values, with reactions in Stanford BCNU (94.7%) being significantly higher than for BEAM (28.6%; P = 0.0003). These findings have resulted in a change of administration of carmustine in Stanford BCNU from 2 to 3 h. Further studies plan to compare the incidence of infusion reactions before and after the change in administration rates. CONCLUSION: Patients receiving rapid infusion of carmustine in the Stanford BCNU regimen for stem cell conditioning have a high rate of infusion reaction. A maximum rate of 3 mg/m(2)/min is recommended.

Janson B; Van Koeverden P; Yip SW; Thakerar A; Mellor JD

2012-10-01

125

Perisciatic infusion of ropivacaine and analgesia after hallux valgus repair  

DEFF Research Database (Denmark)

Moderate to severe pain after hallux valgus repair can be successfully treated with a continuous popliteal sciatic nerve block in ambulatory patients. Different anesthesiologists use various infusion rates for this purpose. The aim of this study was to compare the analgesic efficacy of two infusion rates of ropivacaine 2 mg/ml: 5 and 8 ml/h.

Zaric, D; JØrgensen, B G

2010-01-01

126

Brain activity following esophageal acid infusion using positron emission tomography  

Directory of Open Access Journals (Sweden)

Full Text Available AIM: To investigate symptoms and brain activity following esophageal acid infusion.METHODS: Fifteen healthy volunteers were recruited for the study. Hydrochloric acid (pH 1 and 2) and distilled water (pH 7) were randomly and repeatedly infused into the esophagus. The brain activity was evaluated by positron emission tomography. The severity of heartburn elicited by the infusion was rated on an auditory analog scale of 0-10.RESULTS: The severity of heartburn following each infusion showed a step-wise increase with increasing acidity of the perfusate. The heartburn scores were significantly higher in the second pH 1 infusion compared with the first infusion. Acid and distilled water infusion induced activation of various brain areas such as the anterior insula, temporal gyrus, and anterior/posterior cingulate cortex. At pH 1 or 2, in particular, activation was observed in some emotion-related brain areas such as the more anterior part of the anterior cingulate cortex, parahippocampal gyrus, or the temporal pole. Strong activation of the orbitofrontal cortex was found by subtraction analysis of the two second pH 1 infusions, with a significant increase of heartburn symptoms.CONCLUSION: Emotion-related brain areas were activated by esophageal acid stimulation. The orbitofrontal area might be involved in symptom processing, with esophageal sensitization induced by repeated acid stimulation.

Shigeyuki Kobayashi, Yasuhiko Abe, Manabu Tashiro, Tomoyuki Koike, Katsunori Iijima, Akira Imatani, Shuichi Ohara, Satoshi Watanabe, Shin Fukudo, Tooru Shimosegawa

2010-01-01

127

Cerebral arterial air embolism in a child after intraosseous infusion  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Cerebral arterial air embolism (CAAE) has been reported as a rare complication of medical intervention. There has been one reported case of CAAE after the use of an intraosseous infusion (IO) system. We report on a case of CAAE after tibial IO infusion in a 7-month-old girl during resuscitation.

van Rijn, R. R.; Knoester, H.; Maes, A.; van der Wal, A. C.; Kubat, B.

128

Insulin infusion set: the Achilles heel of continuous subcutaneous insulin infusion.  

UK PubMed Central (United Kingdom)

Continuous subcutaneous insulin infusion from an insulin pump depends on reliable transfer of the pumped insulin to the subcutaneous insulin depot by means of an insulin infusion set (IIS). Despite their widespread use, the published knowledge about IISs and related issues regarding the impact of placement and wear time on insulin absorption/insulin action is relatively small. We also have to acknowledge that our knowledge is limited with regard to how often patients encounter issues with IISs. Reading pump wearer blogs, for instance, suggests that these are a frequent source of trouble. There are no prospective clinical studies available on current IIS and insulin formulations that provide representative data on the type and frequency of issues with infusion sets. The introduction of new IISs and patch pumps may foster a reassessment of available products and of patient problems related to their use. The aim of this review is to summarize the current knowledge and recommendations about IISs and to highlight potential directions of IIS development in order to make insulin absorption safer and more efficient.

Heinemann L; Krinelke L

2012-07-01

129

Insulin Infusion Set: The Achilles Heel of Continuous Subcutaneous Insulin Infusion  

Science.gov (United States)

Continuous subcutaneous insulin infusion from an insulin pump depends on reliable transfer of the pumped insulin to the subcutaneous insulin depot by means of an insulin infusion set (IIS). Despite their widespread use, the published knowledge about IISs and related issues regarding the impact of placement and wear time on insulin absorption/insulin action is relatively small. We also have to acknowledge that our knowledge is limited with regard to how often patients encounter issues with IISs. Reading pump wearer blogs, for instance, suggests that these are a frequent source of trouble. There are no prospective clinical studies available on current IIS and insulin formulations that provide representative data on the type and frequency of issues with infusion sets. The introduction of new IISs and patch pumps may foster a reassessment of available products and of patient problems related to their use. The aim of this review is to summarize the current knowledge and recommendations about IISs and to highlight potential directions of IIS development in order to make insulin absorption safer and more efficient.

Heinemann, Lutz; Krinelke, Lars

2012-01-01

130

Accelerated infliximab infusions for inflammatory bowel disease improve effectiveness  

Directory of Open Access Journals (Sweden)

Full Text Available AIM: To study the safety and effectiveness associated with accelerated infliximab infusion protocols in patients with inflammatory bowel disease (IBD). METHODS: Original protocols and infusion rates were developed for the administration of infliximab over 90-min and 60-min. Then the IBD patients on stable maintenance infliximab therapy were offered accelerated infusions. To be eligible for the study, patients needed a minimum of four prior infusions. An initial infusion of 90-min was given to each patient; those tolerating the accelerated infusion were transitioned to a 60-min infusion protocol at their next and all subsequent visits. Any patient having significant infusion reactions would be reverted to the standard 120-min protocol. A change in a patient’s dose mandated a single 120-min infusion before accelerated infusions could be administered again. RESULTS: The University of Virginia Medical Center's Institutional Review Board approved this study. Fifty IBD patients treated with infliximab 5 mg/kg, 7.5 mg/kg and 10 mg/kg were offered accelerated infusions. Forty-six patients consented to participate in the study. Nineteen (41.3%) were female, five (10.9%) were African American and nine (19.6%) had ulcerative colitis. The mean age was 42.6 years old. Patients under age 18 were excluded. Ten patients used immunosuppressive drugs concurrently out of which six were taking azathioprine, three were taking 6-mercaptopurine and one was taking methotrexate. One of the 46 study patients used corticosteroid therapy for his IBD. Seventeen of the patients used prophylactic medications prior to receiving infusions; six patients received corticosteroids as pre-medication. Four patients had a history of distant transfusion reactions to infliximab. These reactions included shortness of breath, chest tightness, flushing, pruritus and urticaria. These patients all took prophylactic medications before receiving infusions. 46 patients (27 males and 19 females) received a total of fifty 90-min infusions and ninety-three 60-min infusions. No infusion reactions were reported. There were no adverse events, including drug-related infections. None of the patients developed cancer of any type during the study timeframe. Total cost savings for administration of the both 90-min and 60-min accelerated infusions compared to standard 120-min infusions was estimated to be $53?632 ($116?965 vs $63?333, P = 0.001). One hundred and eighteen hours were saved in the administration of the accelerated infusions (17?160 min vs 10?080 min, P = 0.001). In the study population, overweight females [body mass index (BMI) > 25.00 kg/m2] were found to have statistically higher BMIs than overweight males (mean BMI 35.07 ± 2.66 kg/m2 vs 30.08 ± 0.99 kg/m2, P = 0.05), finding which is of significance since obesity was described as being one of the risk factors for Crohn’s disease. CONCLUSION: We are the first US group to report substantial cost savings, increased safety and patient satisfaction associated with accelerated infliximab infusion.

John McConnell; Simona Parvulescu-Codrea; Brian Behm; Beth Hill; Elizabeth Dunkle; Karen Finke; Kathryn Snyder; Anne Tuskey; Debbie Cox; Beth Woodward

2012-01-01

131

CAESAREAN SECTION  

Directory of Open Access Journals (Sweden)

Full Text Available Objective: To determine what surgical techniques are used by obstetricians in Pakistan for caesarean section operations and tocompare it with the recommendation, proposal and guidelines of Royal College of Obstetrician and Gynecologist (RCOG) and CochraneReviews. Methods: A questionnaire was set up regarding surgical technique used during caesarean section and one hundred obstetricianswere part of study. Setting: Hospitals in two large cities of Pakistan i.e. Karachi and Rawalpindi were requested to fill them. Period: Jan 2009 to June 2009. Result: Substantial and remarkable and difference noted in the practice of caesarean section among the obstetricians. Certain practices and procedures performed by our obstetrician are same as proved to be beneficial and valuable based on evidence andrecommended by the RCOG and Cochrane Data on pregnancy. Conclusion: We observed that our obstetricians follow different surgical techniques for performing caesarean section. Some of the techniques follow recommendations by RCOG and provide to effective and beneficial by cochrane data.

HABIBA SHARAF ALI; NEELOFER SALEEM; FARAH AGHA

2010-01-01

132

Evaluation of maternal infusion therapy during pregnancy for fetal development  

Directory of Open Access Journals (Sweden)

Full Text Available The aim of this project was to study the possible association between maternal infusion treatments during pregnancy and variables of fetal development as well as the occurrence of congenital abnormalities (CA) in a case-control design. The large population-based data set of the Hungarian Case?Control Surveillance of Congenital Abnormalities (HCCSCA) was evaluated based on the medically recorded infusion treatment during pregnancy. Of 22,843 case pregnant women who had newborns or fetuses with congenital abnormalities, 112 (0.5%), while of 38,151 control pregnant women who had newborn infants without any defects, 262 (0.7%), had infusion treatment during pregnancy. Infusion treatment was more frequent in the control group than in the case group with congenital abnormalities (adjusted POR with 945 95% CI: 0.7, 0.6-0.9) and there was no higher rate of maternal infusion treatments in any congenital abnormality group. Mean gestational age was shorter and mean birth weight was smaller in control newborn infants without CA born to mothers with infusion treatment during pregnancy than in the babies of mothers without infusion treatment. The prevalence of mild intrauterine growth retardation was more frequent in the fetuses of pregnant women with hyperemesis gravidarum treated with infusion. The results of the study suggest that infusion treatment of pregnant women did not associate with a higher risk of congenital abnormalities. In addition, the intravenous infusion of drugs has some, but limited efficacy to prevent the adverse effects of hyperemesis gravidarum and threatened preterm delivery.

Petik Dóra; Puhó Erzsébet; Czeizel Andrew E.

2005-01-01

133

Randomized Trial of Infusion Set Function: Steel Versus Teflon.  

UK PubMed Central (United Kingdom)

Abstract Background: This study compared infusion set function for up to 1 week using either a Teflon(®) (Dupont(™), Wilmington, DE) catheter or a steel catheter for insulin pump therapy in type 1 diabetes mellitus. Subjects and Methods: Twenty subjects participating in a randomized, open-labeled, crossover study were asked to wear two Quick-Set(®) and two Sure-T(®) infusion sets (both from Medtronic Minimed, Northridge, CA) until the infusion set failed or was worn for 1 week. All subjects wore a MiniMed continuous glucose monitoring system for the duration of the study. Results: One subject withdrew from the study. There were 38 weeks of Sure-T wear and 39 weeks of Quick-Set wear with no difference in the survival curves of the infusion sets. There was, however, a 15% initial failure rate with the Teflon infusion set. After 7 days, both types of infusion sets had a 64% failure rate. Overall, 30% failed because of hyperglycemia and a failed correction dose, 13% were removed for pain, 10% were pulled out by accident, 10% had erythema and/or induration of>10?mm, 5% fell out because of loss of adhesion, and 4% were removed for infection. The main predictor of length of wear was the individual subject. There was no increase in hyperglycemia or daily insulin requirements when an infusion set was successfully used for 7 days (n=25 of 77 weeks). Conclusions: We found no difference between steel and Teflon infusion sets in their function over 7 days, although 15% of Teflon sets failed because of kinking on insertion. The strongest predictor of prolonged 7-day infusion set function was the individual subject, not the type of infusion set.

Patel PJ; Benasi K; Ferrari G; Evans MG; Shanmugham S; Wilson DM; Buckingham BA

2013-10-01

134

Duodenal infusion of donor feces for recurrent Clostridium difficile.  

UK PubMed Central (United Kingdom)

BACKGROUND: Recurrent Clostridium difficile infection is difficult to treat, and failure rates for antibiotic therapy are high. We studied the effect of duodenal infusion of donor feces in patients with recurrent C. difficile infection. METHODS: We randomly assigned patients to receive one of three therapies: an initial vancomycin regimen (500 mg orally four times per day for 4 days), followed by bowel lavage and subsequent infusion of a solution of donor feces through a nasoduodenal tube; a standard vancomycin regimen (500 mg orally four times per day for 14 days); or a standard vancomycin regimen with bowel lavage. The primary end point was the resolution of diarrhea associated with C. difficile infection without relapse after 10 weeks. RESULTS: The study was stopped after an interim analysis. Of 16 patients in the infusion group, 13 (81%) had resolution of C. difficile-associated diarrhea after the first infusion. The 3 remaining patients received a second infusion with feces from a different donor, with resolution in 2 patients. Resolution of C. difficile infection occurred in 4 of 13 patients (31%) receiving vancomycin alone and in 3 of 13 patients (23%) receiving vancomycin with bowel lavage (P<0.001 for both comparisons with the infusion group). No significant differences in adverse events among the three study groups were observed except for mild diarrhea and abdominal cramping in the infusion group on the infusion day. After donor-feces infusion, patients showed increased fecal bacterial diversity, similar to that in healthy donors, with an increase in Bacteroidetes species and clostridium clusters IV and XIVa and a decrease in Proteobacteria species. CONCLUSIONS: The infusion of donor feces was significantly more effective for the treatment of recurrent C. difficile infection than the use of vancomycin. (Funded by the Netherlands Organization for Health Research and Development and the Netherlands Organization for Scientific Research; Netherlands Trial Register number, NTR1177.).

van Nood E; Vrieze A; Nieuwdorp M; Fuentes S; Zoetendal EG; de Vos WM; Visser CE; Kuijper EJ; Bartelsman JF; Tijssen JG; Speelman P; Dijkgraaf MG; Keller JJ

2013-01-01

135

Early mechanism of action of arterially infused ethanol: an experimental study on the influence of infusion speed  

International Nuclear Information System (INIS)

Abdominal aortography and histopathologic examination after absolute ethanol infusion at fast (0.4cc/sec) and slow speed (0.04cc/sec) were performed on 16 rats (2 controls. 7 fast infusion group. 7 slow infusion group). Angiographic and histopathologic findings were correlated and the findings of slow and fast infusion groups were studied. The results are as follows: 1. Histopathologic findings of the fast infusion group revealed wide area of glomerular and tubular collapses, obliteration of the free space between the Bowmann's capsule and glomerulus, sloughing and loss of the endothelium, fresh thrombi attached to the wall, and cleavage of the muscle layer of the arteries. 2. Angiographic findings of the fast infusion group revealed luminal irregularity, early obstruction of the aorta and the renal arteries, and delayed circulation time. 3. Histopathologic findings of the slow infusion group revealed degenerated, coalesced red blood cell packed in the glomeruli, focal areas of severe glomerular and tubular damage on relatively normal background, endothelial and muscular damage of the arteries. 4. Angiographic findings of the slow infusion group revealed focal perfusion defect of the kidney, delayed circulation time, and mild luminal irregularity, but there was no obstruction of the major arteries. 5. In conclusion, author believes that endothelial damage and thrombus formation from the damaged vessel wall, as well as direct cytotoxicity and in situ emboli formation play a significant role in the embolic effect of absolute ethanol.

1988-01-01

136

Early mechanism of action of arterially infused ethanol: an experimental study on the influence of infusion speed  

Energy Technology Data Exchange (ETDEWEB)

Abdominal aortography and histopathologic examination after absolute ethanol infusion at fast (0.4cc/sec) and slow speed (0.04cc/sec) were performed on 16 rats (2 controls. 7 fast infusion group. 7 slow infusion group). Angiographic and histopathologic findings were correlated and the findings of slow and fast infusion groups were studied. The results are as follows: 1. Histopathologic findings of the fast infusion group revealed wide area of glomerular and tubular collapses, obliteration of the free space between the Bowmann's capsule and glomerulus, sloughing and loss of the endothelium, fresh thrombi attached to the wall, and cleavage of the muscle layer of the arteries. 2. Angiographic findings of the fast infusion group revealed luminal irregularity, early obstruction of the aorta and the renal arteries, and delayed circulation time. 3. Histopathologic findings of the slow infusion group revealed degenerated, coalesced red blood cell packed in the glomeruli, focal areas of severe glomerular and tubular damage on relatively normal background, endothelial and muscular damage of the arteries. 4. Angiographic findings of the slow infusion group revealed focal perfusion defect of the kidney, delayed circulation time, and mild luminal irregularity, but there was no obstruction of the major arteries. 5. In conclusion, author believes that endothelial damage and thrombus formation from the damaged vessel wall, as well as direct cytotoxicity and in situ emboli formation play a significant role in the embolic effect of absolute ethanol.

Han, Joon Koo [Seoul District Armed Force General Hospital, Seoul (Korea, Republic of)

1988-12-15

137

Intraarterial infusion chemotherapy for the treatment of metastatic liver cancer  

International Nuclear Information System (INIS)

[en] Some techniques of the most recent interventional radiology are very useful for the treatment of metastatic liver cancer and changing the style of hepatic infusion chemotherapy. This report shows our latest results and methods of hepatic infusion chemotherapy for metastatic liver cancer. 1. For the catheter placement, a new catheterization route via the left subclavian artery into the hepatic artery was developed and performed in 132 cases. Superselective catheterization succeeded in 123 cases (93.2 %). This procedure is less invasive than laparotomy and less troublesome than other percutaneous routes. 2. For useful infusion system, an implantable injection port ''Reservoir'' was developed and it was used in 87 cases. This method makes arterial infusion chemotherapy easy, and imploves their quality of life. 3. To acquire adequate drug delivery, arterial redistribution by steel coils was done, and 109 arteries in 80 cases were occluded. This method is very useful to make multiple hepatic artery single and it is important to avoid gasroduodenal complications. 4. Now, using these techniques, the phase II study of 5FU, ADM, MMC combined hepatic infusion in patients with non-resectable metastatic liver cancer is done. Up to this time, such a phase study on arterial infusion chemotherapy was difficult because of technical problems, but these new techniques make it possible. In conclusion, these new methods change the style and conception of hepatic infusion, and these make much progress on the treatment of patients with metastatic liver cancer. (author)

1987-01-01

138

Systemic response to low-dose endotoxin infusion in cats.  

UK PubMed Central (United Kingdom)

Sepsis is a common problem in feline patients and is associated with substantial morbidity and mortality. There has been little research investigating the physiologic response to bacterial infection in cats, in part because appropriate models have not been developed. The objective of this study was to characterize the response to low-dose LPS infusion in conscious, healthy cats. Measures of systemic inflammation, hemodynamic stability, coagulation, metabolic function, and organ damage were compared between placebo and low-dose LPS infusion (2mcg/kg/hx4h, IV) in cats, with each cat serving as its own control. Markers of systemic inflammation including temperature, plasma TNF activity, IL-6, CXCL-8 and IL-10 concentrations were significantly increased and white blood cell counts were significantly decreased after LPS infusion. A biphasic hypotensive response was observed after initiation of LPS infusion without concurrent tachycardia. Additionally, LPS administration significantly increased blood glucose, lactate and creatinine concentrations. Patchy alveolar congestion, multifocal acute alveolar epithelial necrosis, and mild pulmonary edema were noted in the lungs along with acute centrilobular hepatocellular necrosis, and mild lymphocyte apoptosis in the spleen and/or intestinal Peyer's patches. No biologically significant alterations in coagulation parameters developed after LPS infusion. Low-dose LPS infusion in cats induced systemic inflammation, hemodynamic derangement, metabolic alterations and mild organ damage. Low-dose endotoxin infusion is a viable pre-clinical model to study naturally developing sepsis in cats.

DeClue AE; Williams KJ; Sharp C; Haak C; Lechner E; Reinero CR

2009-12-01

139

Systemic response to low-dose endotoxin infusion in cats.  

Science.gov (United States)

Sepsis is a common problem in feline patients and is associated with substantial morbidity and mortality. There has been little research investigating the physiologic response to bacterial infection in cats, in part because appropriate models have not been developed. The objective of this study was to characterize the response to low-dose LPS infusion in conscious, healthy cats. Measures of systemic inflammation, hemodynamic stability, coagulation, metabolic function, and organ damage were compared between placebo and low-dose LPS infusion (2mcg/kg/hx4h, IV) in cats, with each cat serving as its own control. Markers of systemic inflammation including temperature, plasma TNF activity, IL-6, CXCL-8 and IL-10 concentrations were significantly increased and white blood cell counts were significantly decreased after LPS infusion. A biphasic hypotensive response was observed after initiation of LPS infusion without concurrent tachycardia. Additionally, LPS administration significantly increased blood glucose, lactate and creatinine concentrations. Patchy alveolar congestion, multifocal acute alveolar epithelial necrosis, and mild pulmonary edema were noted in the lungs along with acute centrilobular hepatocellular necrosis, and mild lymphocyte apoptosis in the spleen and/or intestinal Peyer's patches. No biologically significant alterations in coagulation parameters developed after LPS infusion. Low-dose LPS infusion in cats induced systemic inflammation, hemodynamic derangement, metabolic alterations and mild organ damage. Low-dose endotoxin infusion is a viable pre-clinical model to study naturally developing sepsis in cats. PMID:19577810

DeClue, Amy E; Williams, Kurt J; Sharp, Claire; Haak, Carol; Lechner, Elizabeth; Reinero, Carol R

2009-06-11

140

Radiofrequency ablation during continuous saline infusion can extend ablation margins  

Directory of Open Access Journals (Sweden)

Full Text Available AIM: To determine whether fluid injection during radiofrequency ablation (RFA) can increase the coagulation area. METHODS: Bovine liver (1-2 kg) was placed on an aluminum tray with a return electrode affixed to the base, and the liver was punctured by an expandable electrode. During RFA, 5% glucose; 50% glucose; or saline fluid was infused continuously at a rate of 1.0 mL/min through the infusion line connected to the infusion port. The area and volume of the thermocoagulated region of bovine liver were determined after RFA. The Joule heat generated was determined from the temporal change in output during the RFA experiment. RESULTS: No liquid infusion was 17.3 ± 1.6 mL, similar to the volume of a 3-cm diameter sphere (14.1 mL). Mean thermocoagulated volume was significantly larger with continuous infusion of saline (29.3 ± 3.3 mL) than with 5% glucose (21.4 ± 2.2 mL), 50% glucose (16.5 ± 0.9 mL) or no liquid infusion (17.3 ± 1.6 mL). The ablated volume for RFA with saline was approximately 1.7-times greater than for RFA with no liquid infusion, representing a significant difference between these two conditions. Total Joule heat generated during RFA was highest with saline, and lowest with 50% glucose. CONCLUSION: RFA with continuous saline infusion achieves a large ablation zone, and may help inhibit local recurrence by obtaining sufficient ablation margins. RFA during continuous saline infusion can extend ablation margins, and may be prevent local recurrence.

Toru Ishikawa; Tomoyuki Kubota; Ryoko Horigome; Naruhiro Kimura; Hiroki Honda; Akito Iwanaga; Keiichi Seki; Terasu Honma; Toshiaki Yoshida

2013-01-01

 
 
 
 
141

Acute respiratory distress syndrome after aprotinin infusion.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To report a case of acute respiratory distress syndrome (ARDS) following first exposure to aprotinin. CASE SUMMARY: A 24-year-old previously healthy white man was treated with aprotinin infusion because of bleeding following tonsillectomy. The patient had never been treated with aprotinin before, including local application of different hemostatics containing the aprotinin component. Two hours later, hypotension and severe ARDS developed. A full recovery was noted after discontinuation of the drug and prolonged ventilatory support. DISCUSSION: To our knowledge, this is the first reported case of ARDS following first administration of aprotinin, although serious adverse effects at first exposure have been reported. We propose two possible mechanisms for this adverse reaction: a nonallergic or anaphylactoid reaction with direct degranulation of mast cells and basophils by aprotinin, and microthrombosis of the small pulmonary arterioles precipitated by aprotinin. CONCLUSIONS: Most clinicians consider aprotinin to be a safe drug, especially if it has not been administered before. Reexposure carries a high risk of allergic reactions because of possible sensitization. Nonimmunologic, toxic, or idiosyncratic adverse reactions can be expected at first exposure to any drug, as well as to aprotinin.

Vucicevic Z; Suskovic T

1997-04-01

142

Polymyositis and myocarditis after donor lymphocyte infusion.  

Science.gov (United States)

Chronic graft versus host disease (GVHD) is a common late complication of hematopoietic stem cell transplantation. Polymyositis is a rare manifestation of chronic GVHD after donor lymphocyte infusion (DLI). Patients with both polymyositis and myocarditis have not been reported to date. Here, we report an 18-year-old female patient who developed polymyositis and myocarditis after a DLI. The patient developed the symptoms of fever, generalized myalgia, dysarthria, and asymptomatic sinus tachycardia at DLI day +102, and 17 days after the discontinuation of immunosuppressants. The laboratory testing showed elevated muscle enzymes, and the electromyographic examination revealed myopathic abnormalities compatible with the diagnosis of myositis. The muscle biopsy showed CD8+ T cell infiltration of the muscle fibers. The electrocardiogram (ECG) showed sinus tachycardia with an incomplete right bundle branch block, anteroseptal ST elevation and lateral ST depression. Echocardiography showed mild hypokinesia of the left interventricular septal wall without evidence of infection or leukemic relapse. The patient was immediately treated with 60 mg/day of prednisone and tacrolimus after the diagnosis of polymyositis and myocarditis, apparently associated with chronic GVHD. The cardiac and muscle enzymes decreased and the ECG normalized after immunosuppressant treatment. The follow-up ECG 2 weeks after initiation of therapy was normal. PMID:19472035

Ahn, Jae-Sook; Cho, Sang-Hee; Kim, Yeo-Kyeoung; Yang, Deok-Hwan; Bae, Woo Kyun; Shim, Hyun Jeong; Lee, Je-Jung; Chung, Ik-Joo; Juhng, Sang Woo; Kim, Hyeoung-Joon

2009-05-27

143

Polymyositis and myocarditis after donor lymphocyte infusion.  

UK PubMed Central (United Kingdom)

Chronic graft versus host disease (GVHD) is a common late complication of hematopoietic stem cell transplantation. Polymyositis is a rare manifestation of chronic GVHD after donor lymphocyte infusion (DLI). Patients with both polymyositis and myocarditis have not been reported to date. Here, we report an 18-year-old female patient who developed polymyositis and myocarditis after a DLI. The patient developed the symptoms of fever, generalized myalgia, dysarthria, and asymptomatic sinus tachycardia at DLI day +102, and 17 days after the discontinuation of immunosuppressants. The laboratory testing showed elevated muscle enzymes, and the electromyographic examination revealed myopathic abnormalities compatible with the diagnosis of myositis. The muscle biopsy showed CD8+ T cell infiltration of the muscle fibers. The electrocardiogram (ECG) showed sinus tachycardia with an incomplete right bundle branch block, anteroseptal ST elevation and lateral ST depression. Echocardiography showed mild hypokinesia of the left interventricular septal wall without evidence of infection or leukemic relapse. The patient was immediately treated with 60 mg/day of prednisone and tacrolimus after the diagnosis of polymyositis and myocarditis, apparently associated with chronic GVHD. The cardiac and muscle enzymes decreased and the ECG normalized after immunosuppressant treatment. The follow-up ECG 2 weeks after initiation of therapy was normal.

Ahn JS; Cho SH; Kim YK; Yang DH; Bae WK; Shim HJ; Lee JJ; Chung IJ; Juhng SW; Kim HJ

2009-07-01

144

CULTIVATOR SECTION  

UK PubMed Central (United Kingdom)

FIELD: agriculture. ^ SUBSTANCE: section of cultivator comprises beam, bracket with working element fixed on it and adjustment spring. Beam is arranged as elastic. On top above beam there is a limiter installed. ^ EFFECT: such design version will make it possible to reduce energy intensity of process of obstacle bypassing by working element. ^ 3 dwg

KUDZAEV ANATOLIJ BESHTAUOVICH; TSGOEV ALAN EHL BRUSOVICH; KOROBEJNIK IVAN ANATOL EVICH; SAVKHALOV ARTUR BATRAZOVICH; URTAEV TAJMURAZ ASLANBEKOVICH; TSGOEV DAVID VALERIANOVICH

145

A new infusion pathway monitoring system utilizing electrostatic induced potential.  

Science.gov (United States)

We have developed a new infusion pathway monitoring system employing linear integrated circuits and a low-power 8-bit single chip microcomputer. The system is available for hospital and home use and it constantly monitors the intactness of the pathway. The sensor is an electro-conductive polymer electrode wrapped around the infusion polyvinyl chloride infusion tube. This records an AC (alternating current) voltage induced on the patient's body by electrostatic coupling from the normal 100 volt, 60 Hz AC power line wiring field in the patient's room. If the injection needle or infusion tube becomes detached, then the system detects changes in the induced AC voltage and alerts the nursing station, via the nurse call system or PHS (personal handy phone System). PMID:16817637

Maki, Hiromichi; Yonezawa, Yoshiharu; Ogawa, Hidekuni; Ninomiya, Ishio; Sada, Kouji; Hamada, Shingo; Hahn, Alien W; Caldwell, W Morton

2006-01-01

146

A new infusion pathway monitoring system utilizing electrostatic induced potential.  

UK PubMed Central (United Kingdom)

We have developed a new infusion pathway monitoring system employing linear integrated circuits and a low-power 8-bit single chip microcomputer. The system is available for hospital and home use and it constantly monitors the intactness of the pathway. The sensor is an electro-conductive polymer electrode wrapped around the infusion polyvinyl chloride infusion tube. This records an AC (alternating current) voltage induced on the patient's body by electrostatic coupling from the normal 100 volt, 60 Hz AC power line wiring field in the patient's room. If the injection needle or infusion tube becomes detached, then the system detects changes in the induced AC voltage and alerts the nursing station, via the nurse call system or PHS (personal handy phone System).

Maki H; Yonezawa Y; Ogawa H; Ninomiya I; Sada K; Hamada S; Hahn AW; Caldwell WM

2006-01-01

147

Cardiovascular effects of intravenous ghrelin infusion in healthy young men  

Digital Repository Infrastructure Vision for European Research (DRIVER)

  Udgivelsesdato: 2007-Nov , Ghrelin infusion improves cardiac function in patients suffering from cardiac failure, and bolus administration of ghrelin increases cardiac output in healthy subjects. The cardiovascular effects of more continuous intravenous ghrelin exposure remain to be studied. We there...

Vestergaard, Esben Thyssen; Andersen, Niels Holmark; Hansen, Troels Krarup; Rasmussen, Lars Melholt; Møller, N

148

[Target control infusion of propofol: is this method really preferable?  

UK PubMed Central (United Kingdom)

In order to elucidate the advantages of target control infusion (TCI) over common manually controlled infusion, we evaluated the results of 54 anesthesias carried out at department of roentgeno-endovascular surgery. All 54 patients received intravenous controlled sedation with propofol. The rate of arrest of sedation signs after the end of infusion, hemodynamics during anesthesia, comfort for the patient, and convenience for the anesthesiologist were evaluated. As regards intravenous controlled sedation, we observed no obvious advantages of the TCI method for the patient over common manually controlled infusion. Performed by a skilled anesthesiologist, both methods ensure sufficient comfort for the patient, stable hemodynamics, and easy regulation of the depth of sedation. However, TCI is more convenient for physician, and this is the reason why many specialists prefer it.

Kazanikova AN; Likhvantsev VV; Subbotin VV

2002-05-01

149

[Target control infusion of propofol: is this method really preferable?].  

Science.gov (United States)

In order to elucidate the advantages of target control infusion (TCI) over common manually controlled infusion, we evaluated the results of 54 anesthesias carried out at department of roentgeno-endovascular surgery. All 54 patients received intravenous controlled sedation with propofol. The rate of arrest of sedation signs after the end of infusion, hemodynamics during anesthesia, comfort for the patient, and convenience for the anesthesiologist were evaluated. As regards intravenous controlled sedation, we observed no obvious advantages of the TCI method for the patient over common manually controlled infusion. Performed by a skilled anesthesiologist, both methods ensure sufficient comfort for the patient, stable hemodynamics, and easy regulation of the depth of sedation. However, TCI is more convenient for physician, and this is the reason why many specialists prefer it. PMID:12221877

Kazanikova, A N; Likhvantsev, V V; Subbotin, V V

150

Risk factors of ventricular fibrillation during rapid amphotericin B infusion.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Amphotericin B causes reversible concentration-dependent loss of intracellular potassium in vitro and hyperkalemic ventricular arrhythmias in dogs. Hyperkalemic ventricular arrhythmias associated with amphotericin B infusion have not been well documented in humans. Ventricular fibrillation with prog...

Craven, P C; Gremillion, D H

151

Hemodynamic and Metabolic Responses of Infused Low Molecular Weight Dextran.  

Science.gov (United States)

Thirteen series of experiments were conducted to determine some hemodynamic and metabolic responses of infused LMD (low molecular weight dextran, 40,000) in rats. Oxygen consumption, respiratory quotient, circulating histamine levels, arterial and venous ...

E. Evonuk

1966-01-01

152

Radionuclide localization of intraarterial infusions in head and neck cancer  

International Nuclear Information System (INIS)

The therapeutic advantage of intraarterial infusion chemotherapy depends upon delivery of a high drug concentration to the entire tumor bulk with maximum sparing of critical normal tissues. It is clear that successful application of regional therapy must include methodology to assess quantitatively and qualitatively the infused area. /sup 99m/Tc macroaggregated albumin (Tc-MAA) injected intraarterially is held on first pass in the arteriolar capillary bed, thus providing a map of blood flow distribution. Analog and digital planar images and single photon emission computed tomography (SPECT) after Tc-MAA injections provide static and transaxial tomographic images of head and neck intraarterial infusions. SPECT can be viewed as an endless movie-type display, thus producing a rotating cimematic display. These radionuclide localization techniques provide a three-dimensional delineation of the tissues infused, including subsurface details not appreciated with dye injection alone. These procedures should be considered an integral part of intraarterial therapy of head and neck cancer.

1984-01-01

153

Parameter estimations for the cerebrospinal fluid infusion test.  

UK PubMed Central (United Kingdom)

We consider parameter estimation for a single compartment model of a cerebrospinal fluid (CSF) infusion test using an inverse power law cerebral compliance depending on intracranial pressure (ICP). A least squares optimization is used to solve the inverse problem of estimating model parameter values from ICP observed during an infusion test. The optimization is applied to synthetic test data and to clinical ICP data from a number of infusion tests.We show that in tests that successfully reach a new plateau pressure, the resistance to CSF outflow and elastance can be reliably estimated using an automated least squares process. We find that a single infusion test does not provide enough resolution to distinguish between compliance models.

Eisenträger A; Sobey I; Czosnyka M

2013-06-01

154

[Continuous infusion of vancomycin in pediatric critical care].  

UK PubMed Central (United Kingdom)

Continuous infusion of vancomycin may be a strategy for critically ill patients who do not achieve adequate plasma levels. There is few literature on this dosage regimen. We present six children (2 months to 7 years, 4 male and 2 female), admitted to the Intensive Care Unit of the "Prof. Dr. Garrahan Children Hospital", with methicillin-resistant Staphylococcus aureus sepsis, treated with vancomycin 40 and 60 mg/kg/day every 8-6 hrs. Continuous infusion at 50 mg/kg/day was implemented due to poor outcome, persistent fever, positive cultures and inadequate vancomycin plasma levels. All patients achieved levels between 10 and 25 ug/ml, their outcome was favorable and cultures became negative, with no signs of nephrotoxicity. Treatment duration of the continuous infusion was 9 to 18 days. Continuous infusion of vancomycin was effective in these patients without evidence of associated nephrotoxicity.

Zylbersztajn BL; Chicco P; Vega L; Centeno M; Filippini S; Ruvinsky S

2013-01-01

155

Accidental intravenous infusion of air: a concise review.  

UK PubMed Central (United Kingdom)

The unintended intravenous infusion of small volumes of air is common in clinical practice. International Electrotechnical Commission guidelines for infusion pumps permit infusion of up to 1 mL in 15 minutes and discount bubbles smaller than 50 ?L. A review of the literature, however, suggests that these limits may be too generous. Neonates and patients with right-to-left cardiac shunts (eg, patent foramen ovale [PFO]) are at risk from lower volumes. Because PFO is prevalent in 20% to 27% of healthy adults and generally asymptomatic, all patients are at risk from small air bubbles, although clinically significant air embolism from intravenous infusion is rare. Attention to good clinical practice and use of an inline air filter should be considered to reduce any risk.

Wilkins RG; Unverdorben M

2012-11-01

156

Herbal infusions used for induced abortion.  

Science.gov (United States)

Plants and herbs have been used to induce abortions but there is very little published information describing the commonly used ones. The purpose of this report is to describe the herbal products used to induce abortions, and to enhance awareness and understanding of their toxic effects. A descriptive retrospective survey was conducted on the calls received by the Montevideo Poison Centre between 1986 and 1999 concerning the ingestion of herbal infusions with abortive intent. A total of 86 cases involving 30 different plant species were identified. The species most frequently involved were ruda (Ruta chalepensis/graveolens), cola de quirquincho (Lycopodium saururus), parsley (Petroselinum hortense), and an over-the-counter herbal product named Carachipita. The components of Carachipita are pennyroyal (Mentha pulegium), yerba de la perdiz (Margiricarpus pinnatus), oregano (Origanum vulgare), and guaycuri (Statice brasiliensis). Abortion occurred in 23 cases after the ingestion of parsley, ruda, Carachipita, celery, Cedron, francisco alvarez, floripon, espina colorada. Out of the 23 cases, 15 involved the only the ingestion of plants, 4 cases used injected drugs (presumably hormones), and in 4 cases there was associated self-inflicted instrumental manipulation. Multiple organ system failure occurred in those patients who had ingested ruda (alone or in combination with parsley or fennel), Carachipita, arnica, or bardana. Deaths occurred in one case of Carachipita ingestion and in 4 cases of ruda ingestion (2 cases of ruda alone, 2 cases of ruda with parsley and fennel). Self-inflicted instrumental manipulations were found in 4 of the patients with multiple organ system failure and in one of those who died. The results of this report are not conclusive, but it appears that the ingestion of plants to induce abortion involves the risk of severe morbidity and mortality. PMID:12807304

Ciganda, Carmen; Laborde, Amalia

2003-01-01

157

Herbal infusions used for induced abortion.  

UK PubMed Central (United Kingdom)

Plants and herbs have been used to induce abortions but there is very little published information describing the commonly used ones. The purpose of this report is to describe the herbal products used to induce abortions, and to enhance awareness and understanding of their toxic effects. A descriptive retrospective survey was conducted on the calls received by the Montevideo Poison Centre between 1986 and 1999 concerning the ingestion of herbal infusions with abortive intent. A total of 86 cases involving 30 different plant species were identified. The species most frequently involved were ruda (Ruta chalepensis/graveolens), cola de quirquincho (Lycopodium saururus), parsley (Petroselinum hortense), and an over-the-counter herbal product named Carachipita. The components of Carachipita are pennyroyal (Mentha pulegium), yerba de la perdiz (Margiricarpus pinnatus), oregano (Origanum vulgare), and guaycuri (Statice brasiliensis). Abortion occurred in 23 cases after the ingestion of parsley, ruda, Carachipita, celery, Cedron, francisco alvarez, floripon, espina colorada. Out of the 23 cases, 15 involved the only the ingestion of plants, 4 cases used injected drugs (presumably hormones), and in 4 cases there was associated self-inflicted instrumental manipulation. Multiple organ system failure occurred in those patients who had ingested ruda (alone or in combination with parsley or fennel), Carachipita, arnica, or bardana. Deaths occurred in one case of Carachipita ingestion and in 4 cases of ruda ingestion (2 cases of ruda alone, 2 cases of ruda with parsley and fennel). Self-inflicted instrumental manipulations were found in 4 of the patients with multiple organ system failure and in one of those who died. The results of this report are not conclusive, but it appears that the ingestion of plants to induce abortion involves the risk of severe morbidity and mortality.

Ciganda C; Laborde A

2003-01-01

158

Cyclical pamidronate infusions in postmenopausal osteoporosis.  

UK PubMed Central (United Kingdom)

OBJECTIVES: Until recently, two bisphosphonates, pamidronate (APD) and etidronate were available for clinical purposes. Contrary to etidronate, pamidronate was not extensively studied in osteoporosis. Therefore, we investigated the effect of cyclic intravenous APD treatment in postmenopausal osteoporosis. METHODS: Parameters of bone remodelling and lumbar spine bone mineral density (BMDL) were assessed in 36 postmenopausal women with osteoporosis (BMDL t-score < -2.5). They received five courses of APD. Intervals between courses were defined according to the fasting urinary calcium excretion (UCa/Cr, mg/mg creatinine) which was measured before each APD course and every 2 weeks after the first treatment. The patients were retreated when UCa/Cr had reached baseline levels. Serum biochemical parameters and urinary hydroxyproline (UOHPro/Cr, mg/mg) were measured before each APD. RESULTS: UCa/Cr decreased during 21-28 days after each course but UCa/Cr measured before APD infusion remained unchanged. UOHPro/Cr significantly fell after the third APD (P = 0.02). Serum calcium was however not modified. Parameters of bone remodelling decreased with time: bone-GLA protein (BGP) started to fall after the first APD (P = 0.0001) and continued to decrease until the fourth APD course, alkaline phosphatase (ALP) significantly decreased after the first APD (P = 0.005); intact PTH significantly increased at the fifth APD (P = 0.02). BMDL significantly increased after 1 year treatment: +2.9% of baseline value. CONCLUSIONS: Cyclical pamidronate treatment of postmenopausal osteoprosis appeared to be effective in reducing bone turnover assessed by BGP, ALP and OHPro/Cr. This effect is followed by an increase in vertebral BMD.

Peretz A; Body JJ; Dumon JC; Rozenberg S; Hotimski A; Praet JP; Moris M; Ham H; Bergmann P

1996-08-01

159

Transcutaneous oxygen tension during prostacyclin infusion in distal limb ischaemia.  

UK PubMed Central (United Kingdom)

Transcutaneous oxygen tension measurement is an established method for monitoring immediate drug actions. The effects of prostacyclins in advanced limb ischaemia are controversial. To evaluate the immediate effects of epoprostenol infusion (10 ng/kg/min) on forefoot circulation, ten patients with distal ischaemia lesions were evaluated. During infusions systemic blood pressure was lowered, toe temperature elevated but transcutaneous oxygen tension was not changed. These results suggest a vasodilating action of the epoprostenol but contradict immediate positive effects on skin oxygenation.

Lepäntalo M; Hietaniemi K

1990-01-01

160

Large infusion soft bag with hard double-inlet tube  

UK PubMed Central (United Kingdom)

A large soft infusion bag with a hard dual-port pipe cap includes a bag for containing the medicine, which connects to the hard dual-port pipe cap and a composite cover B to seal the hard dual-port pipe cap, this hard dual-port pipe cap is comprised of the hard dual couplings which can fill the medicine to the bag for containing the medicine and output the medicine liquid, a composite cover A which can seal the hard dual couplings and enclasp and seal the needle cylinder of the infusion set during the infusion while the hard dual couplings are comprised of a medicine giving coupling, a infusion coupling is arranged up in parallel with the medicine giving coupling and a connection base which connects the two couplings into a whole body, wherein the medicine giving coupling is comprised of a medicine giving channel and a connection ring B which is placed on the upper end of the medicine giving channel, the medicine giving coupling is connected to the composite cover B sealedly through the connection ring B the infusion coupling is comprised of a medicine output channel and a connection ring A which is placed on the upper end of the medicine output channel, the infusion coupling is connected to the composite cover A sealedly through the connection ring A. The utility model can separate the dosage port and the infusion port, make it convenient and safe to dosage and infuse, thus to avoid the pollution to the medicine liquid, at the same time, the process is simple and the production cost is low.

LIU XIANGHUA PENG

 
 
 
 
161

Subepithelial vocal fold infusion: a useful diagnostic and therapeutic technique.  

UK PubMed Central (United Kingdom)

OBJECTIVES: Preservation of the maximum amount of subepithelial superficial lamina propria (SLP) remains an important goal during microlaryngoscopic surgery of phonatory mucosa. Volume expansion of the SLP (Reinke's space) with subepithelial infusion of saline solution has been widely adopted since its introduction in 1991. This technique has evolved so that it is currently used to assist with determining the depth of vocal fold disease, defining residual pliable SLP, enhancing microsurgical precision, and identifying unrecognized disease. The purpose of this investigation was to examine the indications, methods, and benefits of subepithelial infusion of saline solution as an adjunct technique during phonomicrosurgery. METHODS: In a prospective case series, we collected data on 280 consecutive microlaryngoscopy procedures performed over a 12-month period. Subepithelial infusion of saline solution was included in 178 procedures. RESULTS: New disease was identified in 20 of the 178 patients (scar in 15, sulcus in 4, and a mucosal bridge in 1). The depth of needle placement varied depending on the specific disease: 118 of the 178 infusions were done just below the epithelial basement membrane, and 60 infusions were performed deeper within the SLP, just superficial to the vocal ligament. The infusion technique provided surgical assistance in multiple ways, including identifying residual SLP (130 patients), defining the SLP-lesion interface (65 patients), lifting scar (60 patients),providing tension for cordotomy (47 patients), expanding the SLP volume to protect against laser damage (45 patients), and providing hydrostatic compression of vascular ectasias or varices for photoangiolysis (7 patients). The microlaryngoscopy procedures during which infusion was not performed (102 of 280 procedures) were primarily for nonglottic cancer (46 patients), stenosis (30 patients), or arytenoid granuloma (13 patients). CONCLUSIONS: Subepithelial infusion of the SLP with saline solution is a useful microsurgical adjunct during diagnosis and treatment of phonatory mucosal lesions.

Burns JA; Friedman AD; Lutch MJ; Zeitels SM

2012-04-01

162

Lipolytic response to glucose infusion in human subjects  

International Nuclear Information System (INIS)

[en] The authors have determined the effect of various rates of glucose infusion on the rates of release of glycerol (R/sub a/ glycerol), free fatty acids (R/sub a/ FFA), and on energy metabolism in normal human volunteers. Plasma kinetics were determined with use of the stable isotopic tracers D-5-glycerol and [1-13C]palmitate, and energy metabolism was determined by indirect calorimetry. The effect of glucose infusion on R/sub a/ glycerol and R/sub a/ FFA was dose-dependent. At 4 mg x kg-1 x min-1, both R/sub a/ glycerol and R/sub a/ FFA were suppressed; at 8 mg x kg-1 x min-1, R/sub a/ FFA was even more depressed, but R/sub a/ glycerol was similar to the value during the 4 mg x kg-1 x min-1 infusion. At all infusion rates tested, the amount of potential energy available from the sum of the glucose infusion and endogenously mobilized fat was always greater than when no glucose was infused. Glucose decreased fat mobilization by both inhibiting lipolysis and stimulating reesterification, thus causing a significant increase in triglyceride-fatty acid substrate cycling within the adipose tissue. Plasma insulin was determined by radioimmunoassay

1987-01-01

163

Electro-osmotic infusion for joule heating soil remediation techniques  

Energy Technology Data Exchange (ETDEWEB)

Electro-osmotic infusion of ground water or chemically tailored electrolyte is used to enhance, maintain, or recondition electrical conductivity for the joule heating remediation technique. Induced flows can be used to infuse electrolyte with enhanced ionic conductivity into the vicinity of the electrodes, maintain the local saturation of near-electrode regions and resaturate a partially dried out zone with groundwater. Electro-osmotic infusion can also tailor the conductivity throughout the target layer by infusing chemically modified and/or heated electrolyte to improve conductivity contrast of the interior. Periodic polarity reversals will prevent large pH changes at the electrodes. Electro-osmotic infusion can be used to condition the electrical conductivity of the soil, particularly low permeability soil, before and during the heating operation. Electro-osmotic infusion is carried out by locating one or more electrodes adjacent the heating electrodes and applying a dc potential between two or more electrodes. Depending on the polarities of the electrodes, the induced flow will be toward the heating electrodes or away from the heating electrodes. In addition, electrodes carrying a dc potential may be located throughout the target area to tailor the conductivity of the target area.

Carrigan, Charles R. (Tracy, CA); Nitao, John J. (Castro Valley, CA)

1999-01-01

164

Electro-osmotic infusion for joule heating soil remediation techniques  

Energy Technology Data Exchange (ETDEWEB)

Electro-osmotic infusion of ground water or chemically tailored electrolyte is used to enhance, maintain, or recondition electrical conductivity for the joule heating remediation technique. Induced flows can be used to infuse electrolyte with enhanced ionic conductivity into the vicinity of the electrodes, maintain the local saturation of near-electrode regions and resaturate a partially dried out zone with groundwater. Electro-osmotic infusion can also tailor the conductivity throughout the target layer by infusing chemically modified and/or heated electrolyte to improve conductivity contrast of the interior. Periodic polarity reversals will prevent large pH changes at the electrodes. Electro-osmotic infusion can be used to condition the electrical conductivity of the soil, particularly low permeability soil, before and during the heating operation. Electro-osmotic infusion is carried out by locating one or more electrodes adjacent the heating electrodes and applying a dc potential between two or more electrodes. Depending on the polarities of the electrodes, the induced flow will be toward the heating electrodes or away from the heating electrodes. In addition, electrodes carrying a dc potential may be located throughout the target area to tailor the conductivity of the target area.

Carrigan, C.R.; Nitao, J.J.

1999-11-02

165

Intrastriatal infusions of brain-derived neurotrophic factor: retrograde transport and colocalization with dopamine containing substantia nigra neurons in rat.  

UK PubMed Central (United Kingdom)

The pattern of retrogradely transported BDNF, a member of the nerve growth family of neurotrophins, following intrastriatal infusion was immunohistochemically visualized within the rodent central nervous system. Human recombinant BDNF was infused at a rate of 3 micrograms/h for 7 days with an Alzet 2002 minipump prior to sacrifice. Tissue immunohistochemically processed using a turkey anti-BDNF antibody revealed retrogradely transported BNDF within neurons located mainly within the ipsilateral frontoparietal cortex (predominantly layer V), parafascicular and posterior thalamic nuclei, and substantia nigra, pars compacta. Sections dual immunoreacted for BNNF and tyrosine hydroxylase revealed a subpopulation of dopaminergic neurons (approximately 28%) within the pars compacta which contained retrogradely transported BDNF. Experiments in which a mixture of BDNF and the retrograde tracer fluorogold were simultaneously infused for 7 days into the striatum revealed BDNF and fluorogold single-labeled neurons as well as BDNF and fluorogold dual-labeled cells within the substantia nigra, pars compacta. These observations indicate that only a subpopulation of neurons within the substantia nigra retrogradely transport BDNF following intrastriatal infusion and thus only a subpopulation of cells may be responsive to the trophic influences of BDNF. The retrograde transport of trophins, such as BDNF, represents a unique neuroanatomical tool to selectivity map the location of specific neurotrophin-responsive systems. Unraveling the trophic anatomy of BDNF will aid in understanding its role in development, degeneration, and experimental animal models of regeneration providing essential data for its use in clinical neurodegenerative disorders including Parkinson's disease.

Mufson EJ; Kroin JS; Sobreviela T; Burke MA; Kordower JH; Penn RD; Miller JA

1994-09-01

166

Intrastriatal infusions of brain-derived neurotrophic factor: retrograde transport and colocalization with dopamine containing substantia nigra neurons in rat.  

Science.gov (United States)

The pattern of retrogradely transported BDNF, a member of the nerve growth family of neurotrophins, following intrastriatal infusion was immunohistochemically visualized within the rodent central nervous system. Human recombinant BDNF was infused at a rate of 3 micrograms/h for 7 days with an Alzet 2002 minipump prior to sacrifice. Tissue immunohistochemically processed using a turkey anti-BDNF antibody revealed retrogradely transported BNDF within neurons located mainly within the ipsilateral frontoparietal cortex (predominantly layer V), parafascicular and posterior thalamic nuclei, and substantia nigra, pars compacta. Sections dual immunoreacted for BNNF and tyrosine hydroxylase revealed a subpopulation of dopaminergic neurons (approximately 28%) within the pars compacta which contained retrogradely transported BDNF. Experiments in which a mixture of BDNF and the retrograde tracer fluorogold were simultaneously infused for 7 days into the striatum revealed BDNF and fluorogold single-labeled neurons as well as BDNF and fluorogold dual-labeled cells within the substantia nigra, pars compacta. These observations indicate that only a subpopulation of neurons within the substantia nigra retrogradely transport BDNF following intrastriatal infusion and thus only a subpopulation of cells may be responsive to the trophic influences of BDNF. The retrograde transport of trophins, such as BDNF, represents a unique neuroanatomical tool to selectivity map the location of specific neurotrophin-responsive systems. Unraveling the trophic anatomy of BDNF will aid in understanding its role in development, degeneration, and experimental animal models of regeneration providing essential data for its use in clinical neurodegenerative disorders including Parkinson's disease. PMID:7523178

Mufson, E J; Kroin, J S; Sobreviela, T; Burke, M A; Kordower, J H; Penn, R D; Miller, J A

1994-09-01

167

Mineral Analysis the Infusion of Black Tea Samples by Atomic Absorption Spectrometry  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Tea infusion is one of the most popular drinks around the world. Since tea infusion is known to contain several essential nutrients, it is considered a healthy beverage. In this study eight different Iranian brands of tea infusion and eleven brands imported tea infusion samples from another country...

Lahiji N.; Tadayon F.; Tamiji F.; Lahiji A. H.

168

Physical and chemical stability of cisplatin infusions in PVC containers  

Directory of Open Access Journals (Sweden)

Full Text Available Study objectives: To determine the extended chemical and physical stability of cisplatin infusions in PVC containers at normal in-use concentrations in saline, with and without added electrolyte combinations relevant to clinical practice. Methods: Cisplatin infusions 0.1–0.4 mg/mL were prepared in normal saline, with and without magnesium sulphate and potassium chloride supplements in 500 mL PVC bags, and stored at 25°C protected from light. Chemical stability was assessed by a stability-indicating LC method. Evidence for precipitation was detected by a light-blocking particle count method for sub-visible particles, supported by visual examination. pH and weight changes were also monitored for at least 28 days. Results: Both 0.1 mg/mL and 0.4 mg/mL infusions, with or without the added electrolyte supplements, were chemically stable over 28 days at 25°C. The pH of infusions varied by no more than 0.2 units over this time, there was no visible precipitation, and no significant changes in sub-visual particulate levels or infusion weight. The study was restricted to 28 days because small, visual precipitation was evident in some infusions after 35 days. Conclusion: Cisplatin infusions at concentrations ranging from 0.1–0.4 mg/mL, in 500 mL PVC bags containing either 0.9% sodium chloride or 0.9% sodium chloride + 20 mmoL KCl + 8 mmoL MgSO4 were physically and chemically stable for up to 28 days at 25°C, when protected from light. Extending shelf lives beyond this period is unsafe due to the potential development of precipitates.

Graham Sewell

2010-01-01

169

A comparison of infusion devices at 1 ml/hr.  

UK PubMed Central (United Kingdom)

Delivery of medications by some infusion devices is irregular. This study investigated instantaneous flow in several infusion devices set at a rate of 1 ml/hr. The following devices were tested: Infusion Pumps: IMED 956A, IVAC 570, IVION "Kids Pump." Syringe Pumps: Medfusion, Baxter, Baxter OR. Tests were performed using a Bio-Tek Infusion Device Analyzer (Model IDA-1). Instantaneous flow rate was defined as Q1/T1 where: Q=sample volume and T=time required to deliver sample volume. The infusion devices were received directly from their respective manufacturers and had not seen clinical service before testing. The units were fully charged and were tested while on AC power. The tests were conducted by the authors, using standard infusion sets and commercially prepared 5% dextrose and 0.45% sodium chloride solution. Each pump was tested for several hours and multiple trials were performed on each pump. The infusion pumps, IMED, IVION, and IVAC all demonstrated deviations from the desired flow rate. The IVAC pump had a greater fluctuation in flow from the set value of 1 ml/hr (p less than 0.02). Variances from mean +/- standard error for each device are shown in parenthesis. IMED 965A (0.005+/-0.014), IVION Kid's Pump (0.002+/-0.009), IVAC 570 (0.001+/-0.006). The Baxter syringe pump (0.002+/-0.009) also had a wide variance in flow. The Baxter OR (0.001+/-0.005) and the Medfusion (0.001+/-0.008) syringe pumps maintained the most consistent flow and showed less variance than the other devices tested.(ABSTRACT TRUNCATED AT 250 WORDS)

Wood BR; Huddleston K; Kolm P

1993-05-01

170

Plasma ropivacaine concentrations during bilateral transversus abdominis plane infusions.  

UK PubMed Central (United Kingdom)

BACKGROUND: /st> The transversus abdominis plane (TAP) block is a regional anaesthetic technique that blocks abdominal wall somatic afferent nerves. We conducted a prospective observational study to evaluate the venous plasma concentrations of ropivacaine during a continuous TAP infusion. METHODS: /st> Twenty patients who were planned to undergo intra-abdominal cavity surgery requiring a mid-line laparotomy incision were enrolled. Patients were excluded if they had a history of chronic pain, opioid tolerance, renal or hepatic impairment, or contraindication to study medications. Subjects received a standardized general anaesthetic, and at the completion of surgery, ultrasound-guided subcostal or posterior TAP blocks and catheters. A TAP infusion of 2 mg ml(-1) ropivacaine was administered for 72 h after operation. Data collection during the 72 h included morphine requirements, pain scores, and plasma ropivacaine levels. RESULTS: /st> TAP blocks and catheters were successfully inserted in all recruited subjects. The fourth subject experienced neurological symptoms attributed to local anaesthetic toxicity, but did not have high plasma ropivacaine concentrations. However, the protocol was amended for the subsequent 16 subjects, to a weight-based dosing regimen. The range of total plasma ropivacaine concentrations was 0.98-3.41 mg litre(-1) for posterior infusions and 0.96-3.48 mg litre(-1) for subcostal infusions. Four subjects had total ropivacaine levels >3.4 mg litre(-1). The range of unbound plasma ropivacaine concentrations was 0.022-0.135 mg litre(-1) for posterior infusions and 0.031-0.120 mg litre(-1) for subcostal infusions. CONCLUSION: /st> Given the potential for high plasma concentrations from a bilateral TAP infusion technique, attention should be paid to individualized dosing strategies.

Hessian EC; Evans BE; Woods JA; Taylor DJ; Kinkel E; Bjorksten AR

2013-09-01

171

Intravenous sulprostone infusion in the treatment of retained placenta.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To analyze the effectiveness of intravenous sulprostone infusion for the treatment of retained placenta without massive primary hemorrhage among women at an university hospital over a three-year period. DESIGN: Retrospective observational study. SETTING: University teaching hospital. POPULATION: 126 consecutive women with placental retention and intravenous sulprostone infusion as primary treatment performed from October 2007 up to December 2011. METHODS: Hospital records of women who received sulprostone infusion to attempt placental expulsion were reviewed. MAIN OUTCOME MEASURES: Primary endpoints of the study were expulsion of placenta and the total amount of blood loss during delivery. RESULTS: The placenta was successfully expelled in 39.7% of cases, whereas 60.3% of women underwent manual removal of placenta. Blood loss was significantly lower in women with successful placental expulsion than in women who had manual removal of the placenta (582 ± 431 ml vs. 1275 ± 721 ml, p < 0.0001). Sulprostone infusion did not cause adverse effects or significant postpartum morbidity. CONCLUSIONS: Intravenous sulprostone infusion is safe and reduces both blood loss and the need for manual removal of the placenta.

Stefanovic V; Paavonen J; Loukovaara M; Halmesmäki E; Ahonen J; Tikkanen M

2013-04-01

172

Tocilizumab infusion therapy normalizes inflammation in sporadic ALS patients.  

Science.gov (United States)

Patients with sporadic amyotrophic lateral sclerosis (sALS) show inflammation in the spinal cord and peripheral blood. The inflammation is driven by stimulation of macrophages by aggregated superoxide dismutase 1 (SOD1) through caspase1, interleukin 1 (IL1), IL6 and chemokine signaling. Inflammatory gene activation is inhibited in vitro by tocilizumab, a humanized antibody to IL6 receptor (IL6R). Tocilizumab inhibits global interleukin-6 (IL6) signaling, a key mechanism in chronic rheumatoid disorders. Here we studied in vivo baseline inflammatory gene transcription in peripheral blood mononuclear cells (PBMCs) of 10 sALS patients, and the effects of tocilizumab (Actemra(R)) infusions. At baseline, one half of ALS subjects had strong inflammatory activation (Group 1) (8 genes up regulated >4-fold, PTocilizumab infusions in the Group 1 patients resulted in down regulation of inflammatory genes (in particular IL1?), whereas in the Group 2 patients in up regulation of inflammatory genes. Post-infusion serum and CSF concentrations of tocilizumab inhibited caspase1 activation in vitro. Three of 5 patients receiving tocilizumab infusions showed time-limited attenuation of clinical progression. In conclusion, inflammation of sALS patients at baseline is up- or down-regulated in comparison to controls, but is partially normalized by tocilizumab infusions. PMID:23844337

Fiala, Milan; Mizwicki, Mathew T; Weitzman, Rachel; Magpantay, Larry; Nishimoto, Norihiro

2013-06-21

173

Tocilizumab infusion therapy normalizes inflammation in sporadic ALS patients.  

UK PubMed Central (United Kingdom)

Patients with sporadic amyotrophic lateral sclerosis (sALS) show inflammation in the spinal cord and peripheral blood. The inflammation is driven by stimulation of macrophages by aggregated superoxide dismutase 1 (SOD1) through caspase1, interleukin 1 (IL1), IL6 and chemokine signaling. Inflammatory gene activation is inhibited in vitro by tocilizumab, a humanized antibody to IL6 receptor (IL6R). Tocilizumab inhibits global interleukin-6 (IL6) signaling, a key mechanism in chronic rheumatoid disorders. Here we studied in vivo baseline inflammatory gene transcription in peripheral blood mononuclear cells (PBMCs) of 10 sALS patients, and the effects of tocilizumab (Actemra(R)) infusions. At baseline, one half of ALS subjects had strong inflammatory activation (Group 1) (8 genes up regulated >4-fold, P<0.05 vs. controls) and the other half (Group 2) had weak activation. All patients showed greater than four-fold up regulation of MMP1, CCL7, CCL13 and CCL24. Tocilizumab infusions in the Group 1 patients resulted in down regulation of inflammatory genes (in particular IL1?), whereas in the Group 2 patients in up regulation of inflammatory genes. Post-infusion serum and CSF concentrations of tocilizumab inhibited caspase1 activation in vitro. Three of 5 patients receiving tocilizumab infusions showed time-limited attenuation of clinical progression. In conclusion, inflammation of sALS patients at baseline is up- or down-regulated in comparison to controls, but is partially normalized by tocilizumab infusions.

Fiala M; Mizwicki MT; Weitzman R; Magpantay L; Nishimoto N

2013-01-01

174

Resin infusion of large composite structures modeling and manufacturing process  

Energy Technology Data Exchange (ETDEWEB)

The resin infusion processes resin transfer molding (RTM), resin film infusion (RFI) and vacuum assisted resin transfer molding (VARTM) are cost effective techniques for the fabrication of complex shaped composite structures. The dry fibrous preform is placed in the mold, consolidated, resin impregnated and cured in a single step process. The fibrous performs are often constructed near net shape using highly automated textile processes such as knitting, weaving and braiding. In this paper, the infusion processes RTM, RFI and VARTM are discussed along with the advantages of each technique compared with traditional composite fabrication methods such as prepreg tape lay up and autoclave cure. The large number of processing variables and the complex material behavior during infiltration and cure make experimental optimization of the infusion processes costly and inefficient. Numerical models have been developed which can be used to simulate the resin infusion processes. The model formulation and solution procedures for the VARTM process are presented. A VARTM process simulation of a carbon fiber preform was presented to demonstrate the type of information that can be generated by the model and to compare the model predictions with experimental measurements. Overall, the predicted flow front positions, resin pressures and preform thicknesses agree well with the measured values. The results of the simulation show the potential cost and performance benefits that can be realized by using a simulation model as part of the development process. (au)

Loos, A.C. [Michigan State Univ., Dept. of Mechanical Engineering, East Lansing, MI (United States)

2006-07-01

175

Demonstration of the dorsal pancreatic artery by CTA to facilitate superselective arterial infusion of stem cells into the pancreas  

International Nuclear Information System (INIS)

Purpose: To investigate the diagnostic performance of 64-section CTA in the detection of dorsal pancreatic artery before interventional therapy for patients with diabetes. Materials and methods: The study was approved by the institutional ethics committee; written informed consent was obtained. Forty-two consecutive patients with diabetes received an experimental treatment of autologous bone marrow-derived stem cell transplantation by means of infusion into the dorsal pancreatic artery. All cases underwent abdominal CTA before angiography of pancreatic arteries in order to locate the origin and course of dorsal pancreatic artery. Angiography of coeliac artery, splenic artery, common hepatic artery and superior mesenteric artery were performed both in CTA and DSA. Superselective catheterization of dorsal pancreatic artery was carried out for the infusion of stem cell. Sensitivity, specificity and accuracy for the detection of dorsal pancreatic artery with CTA were calculated using DSA images as the reference standard. Results: Thirty-five and thirty-six dorsal pancreatic arteries were detected by CTA and DSA respectively. Dorsal pancreatic artery was not visualized in either CTA or DSA in 5 patients. The sensitivity, specificity and accuracy for CTA were 94.4%, 83.3% and 92.9%. Conclusion: 64-section CTA is accurate for the detection of dorsal pancreatic artery. It may be useful for the facilitation of superselective arterial infusion of stem cells to pancreas.

2012-01-01

176

Interstitial pressure, volume, and flow during infusion into brain tissue.  

UK PubMed Central (United Kingdom)

A model of infusion-induced swelling in the brain is presented, in which gray and white matter are treated as poroelastic media. The distributions of interstitial pressure, flow, and volume are derived for steady-state and transient infusion protocols. A significant percentage increase in interstitial volume is predicted near the injection site, despite only a modest increase in tissue-averaged fluid content there. The model also can be used to estimate mechanical parameters of brain tissue, such as its hydraulic permeability, shear modulus, and Lamé constant. A solute transport equation that incorporates tissue swelling is also presented. This work suggests that knowing the distribution of swelling induced by infusion is a prerequisite to describing interstitial transport of solutes.

Basser PJ

1992-09-01

177

[Infusion therapy with antidepressants in patients with depression  

UK PubMed Central (United Kingdom)

After a review on the evidence for efficacy of infusions with antidepressants a study is presented which included 100 depressed patients (77 females, 23 males) treated with infusions at a private clinic in Basel. In almost all cases "Ludiomil" and "Anafranil" were administered. Women in the forth decade were the most important age group in the females. Immediately after discharge from the hospital 72.5% of the patients assessed their condition as healthy or markedly improved, 23% as slightly improved, 39% remained well for over 1 year, 14.5% for 7 to 12 months. 26% had previously attempted suicide at least once. Intravenous infusion-therapy with antidepressants has advantages over oral administration of the same substances that are however not solely founded on pharmacologic but also on psychologic reasons.

Haenel T

1993-02-01

178

Effect of intravenous infusion of propantheline bromide on gastric secretion.  

UK PubMed Central (United Kingdom)

The effect of 2 hours' intravenous infusion (7.5 mg/h) of propantheline bromide (Ercotina, Erco Läkemedel AB) on basal or pentagastrin-stimulated gastric secretion was studied in 7 healthy subjects and in 11 patients with acute duodenal ulcer. A moderate to marked decrease in acid secretion rate and acid output was found both in subjects and patients during the infusion period. The acidity decreased in most of the subjects but did not change much in the patients. Two other dose rates (3.75 and 15 mg/h) were studied in a few subjects and patients. The lowest dose rate gave as good an inhibition of the gastric secretion as the higher ones. No troublesome side effects were noticed. It was concluded that a dose rate of around 5-10 mg/h may be suitable for prolonged i.v. infusion, for example as trial therapy in patients with upper gastro-intestinal bleeding.

Furberg B; Krause U; Rimsten A

1975-01-01

179

Effect of intravenous infusion of propantheline bromide on gastric secretion.  

Science.gov (United States)

The effect of 2 hours' intravenous infusion (7.5 mg/h) of propantheline bromide (Ercotina, Erco Läkemedel AB) on basal or pentagastrin-stimulated gastric secretion was studied in 7 healthy subjects and in 11 patients with acute duodenal ulcer. A moderate to marked decrease in acid secretion rate and acid output was found both in subjects and patients during the infusion period. The acidity decreased in most of the subjects but did not change much in the patients. Two other dose rates (3.75 and 15 mg/h) were studied in a few subjects and patients. The lowest dose rate gave as good an inhibition of the gastric secretion as the higher ones. No troublesome side effects were noticed. It was concluded that a dose rate of around 5-10 mg/h may be suitable for prolonged i.v. infusion, for example as trial therapy in patients with upper gastro-intestinal bleeding. PMID:1145899

Furberg, B; Krause, U; Rimsten, A

1975-01-01

180

Antioxidative properties and phytochemical composition of Ballota nigra infusion  

UK PubMed Central (United Kingdom)

The ability of Ballota nigra (Lamiaceae) infusion to act as a scavenger of DPPH radical, reactive oxygen species (superoxide radical, hydroxyl radical, hypochlorous acid) and nitric oxide was investigated. The tested infusion mainly exhibited a potent scavenging effect on DPPH, nitric oxide and superoxide radicals. In hydroxyl radical assay a potent pro-oxidant activity was noticed. No effect was found against hypochlorous acid. A phytochemical study was also undertaken, and seven phenolic compounds (chlorogenic, caffeic and caffeoylmalic acids, ballotetroside, forsythoside B, verbascoside and allysonoside) and eight organic acids (oxalic, aconitic, citric, ascorbic, malic, quinic, shikimic and fumaric acids) were identified and quantified by HPLC/DAD and HPLC/UV, respectively. Forsythoside B and quinic acid were revealed to be the main compounds in this infusion.

Vrchovska? V; Spilkova? J; Valenta?o P; Sousa C; Andrade PB; Seabra RM

2007-01-01

 
 
 
 
181

Intravenous infusion of n-3 polyunsaturated fatty acids.  

UK PubMed Central (United Kingdom)

Dietary supplementation with n-3 polyunsaturated fatty acids (PUFA) is regarded as beneficial for the prevention and treatment of atherosclerosis and thrombosis and chronic inflammatory diseases like rheumatoid arthritis and psoriasis. It may be possible to treat some acute diseases like acute myocardial infarction or acute rejection of grafted organs if it is possible to make n-3 PUFA take effect quickly (in hours instead of days). Three sets of experiments were done. In Experiment 1, emulsion of trieicosapentaenoyl-glycerol (EPA-TG) and tridocosahexaenoyl-glycerol was infused through rabbit ear veins, and the leukotriene B4/B5 production from polymorphonuclear leukocytes was measured at different time points by high-performance liquid chromatography. In Experiment 2, delayed type hypersensitivity (DTH) of mice was measured with sheep red blood cells as an antigen. Pure n-3 PUFA emulsions or a control solution were infused through tail veins just before the second challenge of the antigen. DTH was measured 24 hr after the second challenge. In Experiment 3, human natural killer cell activity was measured using K562 target cells before and after the infusion of pure EPA-TG emulsion to an antecubital vein. Leukotriene B4 production by rabbit polymorphonuclear leukocytes was depressed by 40% by EPA-TG infusion. DTH was suppressed almost completely by n-3 PUFA infusion. Natural killer cell activity was suppressed almost completely by EPA-TG infusion in 8 hr. DTH, natural killer cell activity, and leukotriene B4 production are probably related to acute rejection of grafted organs.(ABSTRACT TRUNCATED AT 250 WORDS)

Hamazaki T

1992-06-01

182

[Adverse events in 1395 infusions with different intravenous gammaglobulin products].  

Science.gov (United States)

The processes of isolation and sterilization of intravenous gamma globulin (IVIG) affect the end product characteristics and, therefore, its tolerability. Different products have different incidences of adverse reactions. The aim of this study was to quantify the immediate adverse events (AE) caused by the different IVIG preparations. We analyzed 1 395 infusions in 28 patients, with a median of 32.5 per subject (range 2-214), using six different IVIG preparations, with an average dose 40.3 ± 8.3 g. One thousand and thirty-one infusions were analyzed retrospectively and 364 prospectively. Patients used a mean of 2.68 ± 1.8 different IVIGs, with a median of 2 (range 1-6) per person. The number of trademarks used was related to the number of infusions received, r = 0.73. AE presented in 24 (2.3%) of 1 031 infusions retrospectively analyzed, affecting 11 of 23 patients enrolled, with a mean of 2.18 ± 1.08 AE per subject. Of 24 patients and 364 infusions prospectively analyzed, AE were observed in 14 patients and in 32 (7.2%) procedures. Twenty-four (42.9%) of 56 AE were mild, 31 (55.5%) moderate and one (1.8%) severe. The infusion rate was 9.04 ± 6 g/h for those presenting AE vs. 10.6 ± 4.6 g/h for those who did not (p = 0.31, NS). The incidence, severity and proportion of patients with AE for each brand of IVIG were very different from each other. This information should be taken into account when selecting the IVIG to be used. PMID:24152399

Malbrán, Alejandro; Larrauri, Blas; Juri, María Cecilia; Fernández Romero, Diego S

2013-01-01

183

Hepatic intra-arterial infusion of fotemustine: pharmacokinetics.  

UK PubMed Central (United Kingdom)

Fotemustine is a new nitrosourea derivative that contains an alpha-aminophosphonic acid and has a short half-life and a high plasma clearance. As myelosuppression occurs as the dose-limiting toxicity, local drug delivery has been investigated in the treatment of liver metastases arising from colorectal cancer. A pharmacokinetic study was undertaken in patients who received either i.v. or hepatic intra-arterial (HIA) infusion of 100 mg/m2 fotemustine so as to estimate the advantage of local chemotherapy, considering the pharmacokinetic differences between the two routes together with the resultant toxicities (when available). Our findings substantiated the hypothesis that a 4-h HIA infusion of foetmustine would result in a lower exposure of healthy tissues to the drug, since the AUC measured in systemic plasma was reduced by approximately 50% following such treatment as compared with i.v. infusion. This reduction in AUC should indicate a manyfold increase in exposure of the liver tumour to the alkylating properties of the drug, since it represents the proportion of the dose that has degraded within the liver. The first-pass liver-extraction ratio of fotemustine given as a 4-h HIA infusion, which ranged from 0.4 to 0.9 as estimated in patients receiving i.v. and HIA infusions in a cross-over study, argues for further investigation of HIA foetemustine infusion for the treatment of liver metastases so as to increase the response rate and decrease the occurrence of major toxic side effects in such patients.

Fety R; Lucas C; Solere P; Cour V; Vignoud J

1992-01-01

184

Hepatic intra-arterial infusion of fotemustine: pharmacokinetics.  

Science.gov (United States)

Fotemustine is a new nitrosourea derivative that contains an alpha-aminophosphonic acid and has a short half-life and a high plasma clearance. As myelosuppression occurs as the dose-limiting toxicity, local drug delivery has been investigated in the treatment of liver metastases arising from colorectal cancer. A pharmacokinetic study was undertaken in patients who received either i.v. or hepatic intra-arterial (HIA) infusion of 100 mg/m2 fotemustine so as to estimate the advantage of local chemotherapy, considering the pharmacokinetic differences between the two routes together with the resultant toxicities (when available). Our findings substantiated the hypothesis that a 4-h HIA infusion of foetmustine would result in a lower exposure of healthy tissues to the drug, since the AUC measured in systemic plasma was reduced by approximately 50% following such treatment as compared with i.v. infusion. This reduction in AUC should indicate a manyfold increase in exposure of the liver tumour to the alkylating properties of the drug, since it represents the proportion of the dose that has degraded within the liver. The first-pass liver-extraction ratio of fotemustine given as a 4-h HIA infusion, which ranged from 0.4 to 0.9 as estimated in patients receiving i.v. and HIA infusions in a cross-over study, argues for further investigation of HIA foetemustine infusion for the treatment of liver metastases so as to increase the response rate and decrease the occurrence of major toxic side effects in such patients. PMID:1451232

Fety, R; Lucas, C; Solere, P; Cour, V; Vignoud, J

1992-01-01

185

Risk factors of ventricular fibrillation during rapid amphotericin B infusion.  

UK PubMed Central (United Kingdom)

Amphotericin B causes reversible concentration-dependent loss of intracellular potassium in vitro and hyperkalemic ventricular arrhythmias in dogs. Hyperkalemic ventricular arrhythmias associated with amphotericin B infusion have not been well documented in humans. Ventricular fibrillation with progressive hyperkalemia (up to 8 to 8.4 meq/liter) occurred twice in an anuric patient during rapid infusion of high-dose amphotericin B (1.4 mg/kg over 45 min). The peak amphotericin B concentration in serum at the end of infusion was 6.7 micrograms/ml. Prolonged infusion (3 h) and concurrent hemodialysis each prevented the development of hyperkalemia and ventricular arrhythmia. In two anuric patients receiving 4-h infusions of amphotericin B during dialysis (0.7 and 1.0 mg/kg), peak amphotericin B concentrations in serum were lower, 1.6 +/- 0.1 and 2.7 +/- 0.7 micrograms/ml, respectively; serum potassium levels were maintained in the normal range; and venous access for outpatient therapy was convenient. Peak concentrations of amphotericin B in serum were also lower (1.7 +/- 0.7 micrograms/ml) in eight patients with normal renal function who received lower doses (0.7 +/- 0.2 mg/kg) over 45 min; there were only slight increases in the serum potassium level (from 3.9 +/- 0.9 to 4.4 +/- 0.6 meq/liter, P less than 0.05). We recommend that rapid infusion of amphotericin B not be used in patients with impaired potassium excretion unless accompanied by hemodialysis and careful potassium monitoring.

Craven PC; Gremillion DH

1985-05-01

186

Risk factors of ventricular fibrillation during rapid amphotericin B infusion.  

Science.gov (United States)

Amphotericin B causes reversible concentration-dependent loss of intracellular potassium in vitro and hyperkalemic ventricular arrhythmias in dogs. Hyperkalemic ventricular arrhythmias associated with amphotericin B infusion have not been well documented in humans. Ventricular fibrillation with progressive hyperkalemia (up to 8 to 8.4 meq/liter) occurred twice in an anuric patient during rapid infusion of high-dose amphotericin B (1.4 mg/kg over 45 min). The peak amphotericin B concentration in serum at the end of infusion was 6.7 micrograms/ml. Prolonged infusion (3 h) and concurrent hemodialysis each prevented the development of hyperkalemia and ventricular arrhythmia. In two anuric patients receiving 4-h infusions of amphotericin B during dialysis (0.7 and 1.0 mg/kg), peak amphotericin B concentrations in serum were lower, 1.6 +/- 0.1 and 2.7 +/- 0.7 micrograms/ml, respectively; serum potassium levels were maintained in the normal range; and venous access for outpatient therapy was convenient. Peak concentrations of amphotericin B in serum were also lower (1.7 +/- 0.7 micrograms/ml) in eight patients with normal renal function who received lower doses (0.7 +/- 0.2 mg/kg) over 45 min; there were only slight increases in the serum potassium level (from 3.9 +/- 0.9 to 4.4 +/- 0.6 meq/liter, P less than 0.05). We recommend that rapid infusion of amphotericin B not be used in patients with impaired potassium excretion unless accompanied by hemodialysis and careful potassium monitoring. PMID:4015077

Craven, P C; Gremillion, D H

1985-05-01

187

Effect of Insulin Infusion on Liver Protein Synthesis during Hemodialysis  

DEFF Research Database (Denmark)

Background Hemodialysis (HD) is a catabolic procedure that may contribute to the high frequency of protein-energy wasting among patients receiving maintenance HD. The present study investigated the additional effect of glucose and glucose-insulin infusion on liver protein synthesis during HD compared with a meal alone. Methods In a randomized cross-over study with three arms, 11 non-diabetic HD patients were assigned to receive a conventional HD session with either: • no treatment (NT) • IV infusion of glucose (G) • IV infusion of glucose-insulin (GI) During infusions blood glucose levels were maintained at 8.0-10.0 mmol/L by additional glucose infusion. Glucose and glucose-insulin infusions were commenced 2 h prior to HD and continued throughout the HD session. Fasting blood samples were collected at baseline before infusion and followed by the only meal allowed during the study. Results Blood glucose and insulin: The change in blood glucose differed significantly from baseline (-120 min) to end of HD (240 min) between the NT group and the G group (p=0.002); there was no significant difference in the change between the NT group and the GI group (p=0.06), or between the G group and the GI group (p=0.15). Fibrinogen and albumin: There was an overall increase in serum albumin (38.8±2.1 to 40.4±2.5 g/L, p<0.0001) and in serum fibrinogen (11.7±1.7 to 12.8±1.8 µmol/L, p<0.0001) from HD start (0 min) to 2 h post HD (360 min), but no significant difference in the change in either albumin (p=0.12) or fibrinogen (p=0.12) between the groups. IGFBP-1: During the first 4 h after baseline (-120 min) we observed an overall decrease in serum IGF-binding protein 1 (IGFBP-1) (from 267±147 to 140±84 µg/L, p<0.0001), but no difference in the change between groups (p=0.41). However, from 4 h after baseline to the end of the study there was a significant difference in the change in serum IGFBP-1 between the groups (p=0.003) with a significant increase in serum IGFBP-1 in the NT group (p<0.0001), but not in the G group or GI group (p=0.50 and p=0.07, respectively). Conclusions Compared with a meal neither glucose nor glucose-insulin infusion appear to have any extra effects on liver protein synthesis during HD.

Reinhard, Mark; Frystyk, Jan

188

Delivery interaction between co-infused medications: an in vitro modeling study of microinfusion.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To test the hypothesis that steady-state drug delivery by continuous infusion is predictably affected by a second drug infusion in the same lumen. BACKGROUND: Clinicians commonly administer two drugs by continuous infusion through one central venous catheter lumen (co-infusion). To limit fluid delivery, low flow rate carriers transport concentrated drug solutions; a method called microinfusion. How microinfusion delivery of one drug is affected by a second drug infusion has not been explored. METHODS: Two water-soluble dyes, tartrazine and erioglaucine, infused at 3 ml · h(-1), modeled drug delivery through a four stopcock linear manifold and catheter lumen. A pump drove a carrier fluid (10 ml · h(-1)). After tartrazine reached steady-state delivery, erioglaucine entered downstream or upstream of the tartrazine infusion. Quantitative spectrophotometry measured dye delivery. RESULTS: Starting erioglaucine's infusion upstream of tartrazine's entry caused a transient tartrazine bolus (duration 10 min, peak drug delivery 20% higher than target levels). Starting erioglaucine's infusion downstream produced a similar amplitude, briefer, bolus. Stopping the erioglaucine infusion caused a transient reduction in tartrazine delivery. Measured delivery profiles were comparable to prediction models. CONCLUSIONS: We confirmed the hypothesis that delivery of one infused drug is transiently affected by starting or stopping a second drug infusion in the same line. The magnitude of the changes can be estimated quantitatively. The clinical impact depends on the drugs being co-infused and patient sensitivity, but could be clinically important; the findings have safety implications for infused medication delivery to critically ill or anesthetized children. We recommend minimizing infusion system dead volumes, connecting the most essential infusion(s) to the main fluid pathway as close as possible to the patient, and recognizing the potential for unintended alterations in delivery when multiple drugs co-infuse.

Tsao AC; Lovich MA; Parker MJ; Zheng H; Peterfreund RA

2013-01-01

189

An experimental study on the influence of infusion speed on the early mechanism of embolic effect of arterially infused absolute Ethanol in the rat  

International Nuclear Information System (INIS)

In order to clarify the early mechanism of action of the tissue necrosis induced by intraarterially infused absolute ethanol, abdominal aortography and histopathologic examination after absolute ethanol infusion into aorta at fast (0.4ml/sec) and slow speed (0.04ml/sec) were performed on 22 rats (2 controls, 7 in fast infusion group, 7 in slow infusion group, 3 in fast and 3 in slow infusion groups during aorta compression, respectively). Histopathologic features under the light and scanning electron microscope were correlated with the angiographic findings within 30 minutes after ethanol infusion. The results are as follows : 1. In fast infusion group, histopathologic examination of the kidney showed severe glomerular and tubular damage. Extensive damage on endothelial and medial layer was noted in arteries, and fresh thrombi originated from the damaged arterial wall were seen. 2. Angiographic findings in the fast infusion group were luminal irregularity and early obstruction of large arteries. And circulation time was prolonged. 3. In slow infusion group, histopathologic examination of the kidney showed focal area of severe glomerular and tubular damage on relatively normal background. Endothelial and muscular damage was noted in arteries, but the degree of the damage was less severe than that of the fast infusion group. 4. Angiographic findings in the slow infusion group were focal perfusion defect of the kidney, delayed circulation time, and mild luminal irregularity, but obstruction of the major arteries was not seen.

1990-01-01

190

Effect of intragastric infusion of tobacco powder on DNA content of gastric aspirate.  

Science.gov (United States)

The DNA content in gastric aspirate was measured before and during intragastric infusion of 0.1 or 0.2 g/hr tobacco powder. The infusion of 0.1 g/hr caused an insignificant rise in the DNA content but infusion of 0.2 g/hr of tobacco caused a marked and rapid rise in the DNA content of gastric aspirate during the hour of infusion. The effect of tobacco was transient (ie, only during the period of infusion). These observations indicate that the increased exfoliation of surface epithelial cells of human gastric mucosa with tobacco infusion is dose related. PMID:1130370

Desai, H G; Venugopalan, K; Anita, F P

1975-05-01

191

Down-regulation of rat kidney calcitonin receptors by salmon calcitonin infusion evidence by autoradiography  

International Nuclear Information System (INIS)

In treating age-related osteoporosis and Paget disease of bone, it is of major importance to avoid an escape phenomenon that would reduce effectiveness of the treatment. The factors involved in the loss of therapeutic efficacy with administration of large pharmacological doses of the hormone require special consideration. Down-regulation of the hormone receptors could account for the escape phenomenon. Specific binding sites for salmon calcitonin (sCT) were characterized and localized by autoradiography on rat kidney sections incubated with 125I-labeled sCT. Autoradiograms demonstrated a heterogeneous distribution of 125I-labeled sCT binding sites in the kidney, with high densities in both the superficial layer of the cortex and the outer medulla. Infusion of different doses of unlabeled sCT by means of Alzet minipumps for 7 days produced rapid changes in plasma calcium, phosphate, and magnesium levels, which were no longer observed after 2 or 6 days of treatment. Besides, infusion of high doses of sCT induced down-regulation of renal sCT binding sites located mainly in the medulla, where calcitonin (CT) has been shown to exert it physiological effects on water and ion reabsorption. These data suggest that the resistance to high doses of sCT often observed during long-term treatment of patients may be the consequence of not only bone-cell desensitization but also down-regulation of CT-sensitive kidney receptor sites.

1987-01-01

192

Animal model of rapid crystalloid infusion in rats  

Directory of Open Access Journals (Sweden)

Full Text Available PURPOSE: To describe an animal model of rapid intravenous infusion with different volumes of crystalloid and discuss the clinical findings. METHODS: Fifty six male Wistar rats were used, divided randomly in seven groups (n = 8). The rats of groups 1 to 6 received lactated Ringer´s solution intravenously, in the rate of 25 ml/min, with different volumes proportional to blood volume (BV). The rats of group 0 were submitted to the same procedure, but did not receive the fluid (control group). The data included respiratory rate, heart rate, saturation of peripheral oxygen (SpO2) in two times (before and after the infusion), and upshots (respiratory arrest and death). Dunnett´s test and ANOVA were used. RESULTS: The clinical signs significantly changed in the 2, 2.5 and 3 fold BV groups. The respiratory arrest was observed in the 1.5, 2, 2.5 and 3 fold BV groups, but death was present only in 2.5 and 3 fold BV groups. CONCLUSIONS: The infusion of crystalloid in the same volume of blood volume did not cause significant variation in respiratory and heart rate, saturation of peripheral oxygen and did not induce respiratory arrest. The infusion of a volume of 3 fold blood volume was lethal to all animals.

Flavio Stillitano Orgaes; Fausto Viterbo de Oliveira Neto; Flavio Henrique Mendes; Renato Florio Yabiku

2013-01-01

193

Pharmacokinetics and pharmacodynamics of nifedipine infusion in normal volunteers.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Two studies of the pharmacokinetics and pharmacodynamics of intravenous nifedipine infusion were performed: the first, a randomised double-blind crossover study of nifedipine and its vehicle in eight subjects, the second a dose ranging study in nine subjects. Nifedipine pharmacokinetics did not vary...

Walley, T J; Heagerty, A M; Woods, K L; Bing, R F; Pohl, J E; Barnett, D B

194

Pharmacokinetics of Ertapenem following Intravenous and Subcutaneous Infusions in Patients?  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Steady-state pharmacokinetics of ertapenem were compared in patients after 1-g intravenous and subcutaneous (s.c.) infusions. Bioavailability was 99% ± 18% after s.c. administration, but peaks were reduced by about (43 ± 29 versus 115 ± 28 ?g/ml) and times to peak were delayed. Simulations based on ...

Frasca, Denis; Marchand, Sandrine; Petitpas, Franck; Dahyot-Fizelier, Claire; Couet, William; Mimoz, Olivier

195

Predictors of acute adverse events from rapid rituximab infusion.  

UK PubMed Central (United Kingdom)

PURPOSE: This study aimed to identify the predictors of acute adverse events resulting from rapid rituximab infusion over 90 min. METHOD: It was a retrospective cohort study using medical record review based on a convenience sampling from 2007 till May 2011 in both in-patient and ambulatory setting in Royal Adelaide Hospital. RESULTS: There were a total of 294 patients who received 376 courses and 1,571 cycles of rapid rituximab infusion. Forty-three (14.6 %) patients experienced acute adverse events of hypotension being the most commonly occurring events followed by patients feeling hot and face-flushed. There were 11 predictors analysed, namely age, gender, diagnosis, stage of disease, presence of cardiac or lung morbidities, type of treatment, number of course and cycles, total white blood cells count, lymphocyte counts and lactate dehydrogenase using log generalised estimating equation for univariate and multivariate analysis. The findings successfully demonstrated that high lymphocyte counts were the independent predictor of acute adverse event from rapid rituximab infusion (p = 0.0009). Patient with high lymphocyte counts were 6.9382 times the odd to experience an adverse event as compared to those with normal lymphocyte counts. CONCLUSION: There are no specific patient characteristics to preclude prescribing rapid rituximab infusion following a 90-min regimen for non-Hodgkin lymphoma except a potential for adverse events to occur when patients have abnormally high lymphocyte counts.

Lang DS; Keefe DM; Schultz T; Pearson A

2013-08-01

196

Outcome of dual infusion through irrigating chopper in conventional phacoemulsification.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To determine the operative advantage in terms of minimizing the complications following conventional phaco surgery with dual infusion through irrigating chopper. METHODS: A Randomized Controlled Clinical Trial (RCCT) was conducted in the Ophthalmology Unit-III, Sindh Government Lyari General Hospital and DUHS and Al-Noor Eye Hospital Karachi, from March 2008 to February 2009. A total of 200 eyes with nuclear/cortico-nuclear cataract on Lens Opacity Classification System III underwent phacoemulsification. In all 100 eyes in group A were randomized to have conventional phacoemulsification with dual infusion technique through irrigating chopper and another 100 eyes in group B by conventional phaco surgery. Outcomes in two groups were judged by amount of Ringer's Lactate used, stability of anterior chamber and number of complications observed. RESULTS: Rate of intra-operative complications was lower in group A as compared to group B (p=0.002). Anterior chamber depth was maintained in all cases of group A while it collapsed in 9 cases of group B which was highly significant (p=0.003). Mean amount of Ringer's Lactate used in group A was 260.2 +/- 55.07 ml and 195.8 +/- 35.0 ml in group B, which was significantly high (p<0.001). CONCLUSION: Dual infusion through irrigating chopper serves triple function of irrigation, chopping and additional separate distant infusion. It improves anterior chamber stability and compensates surge and operative advantage to surgeon.

Wahab S; Faiz-ur-Rab K; Hargun LD

2011-02-01

197

Curriculum Infusion as College Student Mental Health Promotion Strategy  

Science.gov (United States)

This article describes efforts to increase faculty involvement in suicide prevention and mental health promotion via curriculum infusion. The participants were faculty, staff, and 659 students enrolled in classes of a large eastern university from Fall 2007-Spring 2011. Counselors, health educators, and medical providers recruited faculty from a…

Mitchell, Sharon L.; Darrow, Sherri A.; Haggerty, Melinda; Neill, Thomas; Carvalho, Amana; Uschold, Carissa

2012-01-01

198

Technology Infusion in a Chinese Middle School: A Comparative Perspective.  

Science.gov (United States)

This paper reports on an investigation of technology infusion at QiBao Middle School, one of the leading secondary schools in Shanghai (China). Major focuses of the study are models of professional development for teachers and how teachers enlist the help of their students. Results are presented related to: technology infrastructure; technology…

Lan, Jiang; He, Shujia; Ouyang, John Ronghua; Zhonghai, Qiu; Bao, Qiu

199

Reduction of Reaction due to Iron Dextran Infusion using Chloroquine  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The use of promethazine and chloroquine sulphate to reduce reaction to total dose infusion of iron dextran (Imferon) is described. The patients chosen for the investigation were anaemic pregnant African women living in the coastal region of East Africa where malaria due to Plasmodium falciparum is h...

Byles, A. B.; D'sa, Avita

200

Impaired bacteriological responses in babies after maternal iron dextran infusion.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The effect of a total dose infusion of iron dextran in pregnancy on 15 mothers and their babies was compared with 19 controls. The bacteriostatic effect and opsonising ability of the sera, of babies born to the treated mothers, were considerably impaired. This was associated with a significantly low...

Webster, M H; Waitkins, S A; Stott, A

 
 
 
 
201

A model of chronic nutrient infusion in the rat.  

Science.gov (United States)

Chronic exposure to excessive levels of nutrients is postulated to affect the function of several organs and tissues and to contribute to the development of the many complications associated with obesity and the metabolic syndrome, including type 2 diabetes. To study the mechanisms by which excessive levels of glucose and fatty acids affect the pancreatic beta-cell and the secretion of insulin, we have established a chronic nutrient infusion model in the rat. The procedure consists of catheterizing the right jugular vein and left carotid artery under general anesthesia; allowing a 7-day recuperation period; connecting the catheters to the pumps using a swivel and counterweight system that enables the animal to move freely in the cage; and infusing glucose and/or Intralipid (a soybean oil emulsion which generates a mixture of approximately 80% unsaturated/20% saturated fatty acids when infused with heparin) for 72 hr. This model offers several advantages, including the possibility to finely modulate the target levels of circulating glucose and fatty acids; the option to co-infuse pharmacological compounds; and the relatively short time frame as opposed to dietary models. It can be used to examine the mechanisms of nutrient-induced dysfunction in a variety of organs and to test the effectiveness of drugs in this context. PMID:23979115

Fergusson, Grace; Ethier, Mélanie; Zarrouki, Bader; Fontés, Ghislaine; Poitout, Vincent

2013-08-14

202

A model of chronic nutrient infusion in the rat.  

UK PubMed Central (United Kingdom)

Chronic exposure to excessive levels of nutrients is postulated to affect the function of several organs and tissues and to contribute to the development of the many complications associated with obesity and the metabolic syndrome, including type 2 diabetes. To study the mechanisms by which excessive levels of glucose and fatty acids affect the pancreatic beta-cell and the secretion of insulin, we have established a chronic nutrient infusion model in the rat. The procedure consists of catheterizing the right jugular vein and left carotid artery under general anesthesia; allowing a 7-day recuperation period; connecting the catheters to the pumps using a swivel and counterweight system that enables the animal to move freely in the cage; and infusing glucose and/or Intralipid (a soybean oil emulsion which generates a mixture of approximately 80% unsaturated/20% saturated fatty acids when infused with heparin) for 72 hr. This model offers several advantages, including the possibility to finely modulate the target levels of circulating glucose and fatty acids; the option to co-infuse pharmacological compounds; and the relatively short time frame as opposed to dietary models. It can be used to examine the mechanisms of nutrient-induced dysfunction in a variety of organs and to test the effectiveness of drugs in this context.

Fergusson G; Ethier M; Zarrouki B; Fontés G; Poitout V

2013-01-01

203

Doing Business with China: Curriculum Internationalisation through an Infusion Method  

Science.gov (United States)

The US apparel and textiles industry operates within an interdependent global system, necessitating workforces competent for day-to-day operations. The US workforce lacks preparedness in working globally; this study tests an infusion method of curriculum internationalisation to enhance students' global understanding. Four cognitive and…

Jin, Byoungho; Swinney, Jane; Cao, Huantian; Muske, Glenn; Nam, Jinhee; Kang, Ji Hye

2011-01-01

204

Unremarkable errors: low-level disturbances in infusion pump use  

Digital Repository Infrastructure Vision for European Research (DRIVER)

In this paper we describe results from an exploratory study observing infusion pump use in practice. From 31 observations of pump programming we note 10 low-level disturbances, which we conceptualise in terms of unremarkable error. This data supports a view that well performing systems cope with err...

Furniss, DJ; Blandford, A; Mayer, A

205

Fat embolism in infancy after intravenous fat infusions.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Four cases of fat embolism are described in infants receiving prolonged intravenous infusion of fat (Intralipid 20%). This therapeutic complication has been termed 'fat overloading syndrome' but bears a clinical similarity to post-traumatic fat embolism. These 4 cases are the first to be recorded in...

Barson, A J; Chistwick, M L; Doig, C M

206

Melissa officinalis and Passiflora caerulea infusion as physiological stress decreaser.  

UK PubMed Central (United Kingdom)

The objective of this study was to determine the effect of a Melissa officinalis and Passiflora caerulea infusion on the severity of physiological chronic stress induced by movement restriction in CF-1 mice. 40 CF-1 male mice, six weeks of age, were divided into 4 groups (n = 10 for each group): (1) Group RS/MP received two treatments, induced stress through movement restriction and a infusion of Melissa officinalis and Passiflora caerulea in a dose of 200 mg/kg, (2) RS group with induced stress using movement restriction, (3) MP group, which received only a infusion, and (4) a CONTROL group that received no treatment. The severity of the stress was obtained by analysis of the physical parameters of body weight, thymus and spleen, and associated biomarkers with stress, corticosterone, and glucose. Animals that consumed Melissa officinalis and Passiflora caerulea infusion had lower plasma corticosterone levels (Student's t test, Welch, p = 0.05), which is the most important biomarker associated with physiological stress, demonstrating a phytotherapy effect.

Feliú-Hemmelmann K; Monsalve F; Rivera C

2013-01-01

207

Animal model of rapid crystalloid infusion in rats  

Scientific Electronic Library Online (English)

Full Text Available Abstract in english PURPOSE: To describe an animal model of rapid intravenous infusion with different volumes of crystalloid and discuss the clinical findings. METHODS: Fifty six male Wistar rats were used, divided randomly in seven groups (n = 8). The rats of groups 1 to 6 received lactated Ringer´s solution intravenously, in the rate of 25 ml/min, with different volumes proportional to blood volume (BV). The rats of group 0 were submitted to the same procedure, but did not receive the flu (more) id (control group). The data included respiratory rate, heart rate, saturation of peripheral oxygen (SpO2) in two times (before and after the infusion), and upshots (respiratory arrest and death). Dunnett´s test and ANOVA were used. RESULTS: The clinical signs significantly changed in the 2, 2.5 and 3 fold BV groups. The respiratory arrest was observed in the 1.5, 2, 2.5 and 3 fold BV groups, but death was present only in 2.5 and 3 fold BV groups. CONCLUSIONS: The infusion of crystalloid in the same volume of blood volume did not cause significant variation in respiratory and heart rate, saturation of peripheral oxygen and did not induce respiratory arrest. The infusion of a volume of 3 fold blood volume was lethal to all animals.

Orgaes, Flavio Stillitano; Oliveira Neto, Fausto Viterbo de; Mendes, Flavio Henrique; Yabiku, Renato Florio

2013-04-01

208

Can infusion tests be recommended for patients with giant hydrocephalus?  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Background : The problem of adequate diagnosis of hydrocephalus followed by administration of an effective treatment has not yet been properly solved. Specifically, this pertains to the decision about the surgical insertion of a flow diverting device. Aims : A lumbar infusion test was...

Cieslicki Krzysztof; Czepko Ryszard

209

Methotrexate infusion in low-risk gestational trophoblastic disease  

Digital Repository Infrastructure Vision for European Research (DRIVER)

OBJECTIVES: The current study attempts to evaluate the effectiveness of methotrexate infusion therapy in the management of low-risk gestational trophoblastic disease and to find out whether an increase in the dose intensity can effect a faster remission and a shorter treatment duration. STUDY DESIGN...

Wong, LC; Ngan, HYS; Cheng, DKL; Ng, TY

210

Evaluation of oviposition substrates and organic infusions on collection of Culex in Florida.  

UK PubMed Central (United Kingdom)

Gravid mosquito traps are commonly used for both arbovirus surveillance and population surveillance of mosquitoes of the genus Culex. Oviposition substrates, used as baits in these traps, were tested against Culex under laboratory and field conditions. In the laboratory all substrates tested as 1% and 10% dilutions in 2-choice bioassays against female Cx. quinquefasciatus were significantly more effective than well water controls in eliciting oviposition. Strongest responses were to dilutions of dairy effluent, followed by larval water and infusions of alfalfa hay, alfalfa pellets, Bermuda hay, oak leaves, and Typha leaves, with lowest responses to cow manure infusion. In the field, few significant differences in collections were obtained between traps baited with different infusions. Significantly more Cx. quinquefasciatus and Cx. nigripalpus were collected in traps baited with cow manure infusion (highest) compared to alfalfa hay infusion (lowest). Responses of Cx. quinquefasciatus to dairy effluent and infusions of Bermuda hay, oak leaves, and Typha leaves were not significantly different from either cow manure infusion or alfalfa hay infusion. Responses of Cx. nigripalpus were highest to cow manure infusion and equally low to infusions of alfalfa hay and Typha leaves; moderate responses were observed to dairy effluent and infusions of Bermuda hay and oak leaves. Gravid females comprised 66.7-81.9% of the collections for each infusion type, with no significant difference among infusions in the proportion of gravid females collected.

Allan SA; Bernier UR; Kline DL

2005-09-01

211

Influence of leucine infusion on intracellular amino acids in humans.  

UK PubMed Central (United Kingdom)

A continuous intravenous infusion of L-leucine (300 mumols min-1) was given to 12 healthy females over a 2 1/2 h period. Arterial plasma concentrations of amino acids and the keto acids of the branched-chain amino acids (BCAA) were measured. In six subjects muscle biopsies were taken before and at the end of the infusion for determination of intracellular (i.c.) free amino acid concentrations, and leg exchange of amino acids was measured. During infusion the plasma level of leucine rose sixfold. Approximately 40% of the infused amount was taken up by muscle. Of this, half was accumulated intracellularly, where the free leucine concentration increased from basal 190 +/- 22 to 580 +/- 110 mumols l-1 ICW (intracellular water) at the end of infusion. The concentrations of most other amino acids, above all the other BCAA and the aromatic amino acids, decreased, by 17-48% in the i.c. pool and by 17-79% in plasma. The plasma level of ketoisocaproic acid (KIC), the keto acid of leucine, increased in parallel with that of leucine. The concentration of keto valine, ketoisovaleric acid (KIV), decreased by 75%, whereas the keto acid of isoleucine, ketomethylvaleric acid (KMV), was unchanged. Leg release of alanine decreased significantly, whereas the exchange of other amino acids were unchanged. Taken together, decreased i.c. and plasma concentrations but unchanged leg exchange of tyrosine and phenylalanine suggest i.c. accumulation of protein. It can be calculated that approximately 40% of the leucine taken up by muscle was accumulated in the intracellular free pool, some 20% could have been incorporated into protein and 40% was probably oxidized.

Alvestrand A; Hagenfeldt L; Merli M; Oureshi A; Eriksson LS

1990-06-01

212

Influence of leucine infusion on intracellular amino acids in humans.  

Science.gov (United States)

A continuous intravenous infusion of L-leucine (300 mumols min-1) was given to 12 healthy females over a 2 1/2 h period. Arterial plasma concentrations of amino acids and the keto acids of the branched-chain amino acids (BCAA) were measured. In six subjects muscle biopsies were taken before and at the end of the infusion for determination of intracellular (i.c.) free amino acid concentrations, and leg exchange of amino acids was measured. During infusion the plasma level of leucine rose sixfold. Approximately 40% of the infused amount was taken up by muscle. Of this, half was accumulated intracellularly, where the free leucine concentration increased from basal 190 +/- 22 to 580 +/- 110 mumols l-1 ICW (intracellular water) at the end of infusion. The concentrations of most other amino acids, above all the other BCAA and the aromatic amino acids, decreased, by 17-48% in the i.c. pool and by 17-79% in plasma. The plasma level of ketoisocaproic acid (KIC), the keto acid of leucine, increased in parallel with that of leucine. The concentration of keto valine, ketoisovaleric acid (KIV), decreased by 75%, whereas the keto acid of isoleucine, ketomethylvaleric acid (KMV), was unchanged. Leg release of alanine decreased significantly, whereas the exchange of other amino acids were unchanged. Taken together, decreased i.c. and plasma concentrations but unchanged leg exchange of tyrosine and phenylalanine suggest i.c. accumulation of protein. It can be calculated that approximately 40% of the leucine taken up by muscle was accumulated in the intracellular free pool, some 20% could have been incorporated into protein and 40% was probably oxidized. PMID:2114990

Alvestrand, A; Hagenfeldt, L; Merli, M; Oureshi, A; Eriksson, L S

1990-06-01

213

Can infusion tests be recommended for patients with giant hydrocephalus?  

Directory of Open Access Journals (Sweden)

Full Text Available Background : The problem of adequate diagnosis of hydrocephalus followed by administration of an effective treatment has not yet been properly solved. Specifically, this pertains to the decision about the surgical insertion of a flow diverting device. Aims : A lumbar infusion test was used to examine the compensatory parameters of intracranial space in giant hydrocephalus. The early and late results of shunt implantation were analyzed together with complications after surgery. Settings and Design : In-house software was used offline to adjust the dynamic intracranial pressure (ICP) response to infusion. Materials and Methods : Nine patients with giant hydrocephalus were the subjects for the study. We analyzed recordings of the response in ICP to the 2 ml/min infusion of saline. We performed computerized identification of outflow resistance and intracranial compliance based on the truncated (30- 100%) ICP response and assessed the stability of estimates over time. Eight out of nine patients were shunted. Monitoring of patients was followed for a period of up to 9 months. Results : Five out of eight shunted patients improved within a few days of surgery. During follow-up five patients developed various complications. A definite improvement was noted in four patients. The improvement rate did not correlate with any of the compensatory parameters. Most of the patients studied exhibited a lack of intracranial space reserve, a significantly reduced rate of CSF secretion, and a slightly elevated value of outflow resistance. Conclusions : The infusion test showed itself to be more useful as a way of revealing the compensatory parameters of the intracranial space than as a prognostic tool. The outcome of shunted patients with giant hydrocephalus was uncertain, owing to the relatively high rate of complications. We may therefore suggest that the diagnosis of giant hydrocephalus is a relative contraindication to implantation, as well as to the performance of an infusion test.

Cieslicki Krzysztof; Czepko Ryszard

2010-01-01

214

Sectionalized marine seismic cable  

Energy Technology Data Exchange (ETDEWEB)

A marine seismic cable is sectionalized with the individual cable sections being joined by articulated connector assemblies which permit relative bending movement between such individual cable sections.

Neeley, W.P.

1984-05-22

215

A comparison of three different target-controlled remifentanil infusion rates during target-controlled propofol infusion for oocyte retrieval  

Scientific Electronic Library Online (English)

Full Text Available Abstract in english OBJECTIVE: To evaluate the effects of three different target-controlled remifentanil infusion rates during target-controlled propofol infusion on hemodynamic parameters, pain, sedation, and recovery score during oocyte retrieval. METHODS: Sixty-nine women were scheduled for oocyte retrieval. Target-controlled propofol infusion at an effectsite concentration of 1.5 ?g/mL was instituted. The patients were randomly allocated to receive remifentanil at an effect-site con (more) centration of either 1.5 (group I, n = 23), 2 (group II, n = 23) or 2.5 ng/mL (group III, n = 23). Hemodynamic variables, sedation, pain, the Aldrete recovery score, and side effects were recorded. RESULTS: Hemodynamic variables, sedation and pain scores and the number of patients with the maximum Aldrete recovery score 10 min after the procedure were comparable among the groups. The number of patients in group III with the maximum Aldrete recovery score 5 min after the procedure was significantly lower than that in groups I and II. One patient in group II and one patient in group III suffered from nausea. CONCLUSION: Similar pain-free conscious sedation conditions without significant changes in hemodynamic parameters were provided by all three protocols. However, target controlled infusion of remifentanil at 1.5 or 2 ng/mL proved superior at providing early recovery compared to 2.5 ng/mL.

Coskun, Demet; Gunaydin, Berrin; Tas, Ayca; Inan, Gozde; Celebi, Hulya; Kaya, Kadir

2011-01-01

216

Infusion medium delivery device with drive device for driving plunger in reservoir  

UK PubMed Central (United Kingdom)

Infusion medium delivery device for delivering an infusion medium to a user, with first and second housing portions, the device having a specific drive structure including a nut member and a rotatable lead shaft supported by the second housing portion.

MOBERG SHELDON B; HANSON IAN B; BENTE PAUL F; TIECK RUTH MARIE; KAVAZOV JULIAN D; GRIFFIN CHRISTOPHER; CHONG COLIN A; HOLT MARK D; MOUNCE PAUL R; HUDAK PHILIP J; NORTON MELISSA D; GUEZURAGA ROBERT M; ENEGREN BRADLEY J; MAULE SUSIE E; KOVELMAN PAUL H

217

Study of Cisatracurium and Sufentanil Consumption Using a Closed Loop Computer Control Infusion System  

Science.gov (United States)

The Intraoperative Effect of Dexmedetomidine on Cisatracurium Infusion Consumption and Its Recovery Index.; Effect of Dexmedetomidine on Sufentanil Consumption.; Quantitative Analysis of Cisatracurium Infusion Requirements, Sufentanil Consumption and Recovery Index in Different Age Groups.

2013-02-06

218

The home infusion formula: high tech + high touch = high-quality home care.  

UK PubMed Central (United Kingdom)

Case studies show that home infusion benefits a variety of patients, from ambulatory to pediatric patients. The first year of a home infusion program can offer many lessons for providers interested in starting their own programs.

Weaver J; Simmons G; Schofield RL

1995-05-01

219

Using miniature osmotic infusion pumps to maintain tritiated thymidine exposure to cells in culture  

Energy Technology Data Exchange (ETDEWEB)

To provide a constant level of tracer doses of tritiated thymidine to cultured cells during continuous infusion, miniature osmotic infusion pumps were used to provide replacement thymidine. By determining the loss of isotope from the media during nonreplacement, the rate of constant infusion replacement to maintain thymidine levels was calculated. The replacement rates were similar for the three cell lines examined and allowed a standard osmotic pump infusion.

Neely, J.E.; Hake, D.A.

1982-06-01

220

Use of nitric oxide producer L-arginine during infusion therapy of experimental hemorrhagic shock.  

UK PubMed Central (United Kingdom)

Experiments on rats showed that infusion of NO precursor L-arginine before bleeding enhanced their tolerance to hemorrhagic shock. When infused after blood loss as a component of saline solution, L-arginine improved efficiency of infusion therapy for hemorrhagic shock and increased survival rate of the animals.

Grishina GV; Gerbut KA; Remizova MI; Selivanov EA

2013-01-01

 
 
 
 
221

Optimisation of drilling equipment for drilling long infusion holes. Optimierung der Bohrausruestung zum Bohren langer Traenkloecher  

Energy Technology Data Exchange (ETDEWEB)

Concentration of the operating points requires compensation for the operating processes to an increasing extent. In coal face infusion intensification of the longwall fusion is a suitable measure. The mechanical engineering had to be optimised for the planned drilling of long infusion holes, which enable longwall infusion ahead of the face from only one gate road without additional measures on the face. (orig.).

Betting, K.; Stockmann, H.W.; Henke, B.

1992-05-14

222

Design of occlusion pressure testing system for infu-sion pump  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Reliability of medical devices such as infusion pumps is extremely important because these devices are being used in patients who are in critical condition. Occlusion pressure, as an important parameter of infusion pumps, should be detected when an occlusion occurred. How-ever, infusion pumps’ occlu...

Peng Zhang; Shu-Yi Wang; Chuan-Yi Yu; Min-Yan Zhang

223

Species Variability in the Cardiovascular and Hematologic Effects of Zymosan-Activated Plasma Infusion.  

Science.gov (United States)

The purpose of this study was to compare the effects of zymosan-activated plasma (ZAP) infusion in dogs, sheep, and baboons. ZAP was infused into dogs, baboons, and sheep. The infusion of ZAP resulted in significant changes in heart rate (HR) mean arteria...

L. C. Casey J. R. Fletcher B. Chernow P. W. Ramwell

1986-01-01

224

Studies on the subcommissural organ area in the rat: the effects aldosterone infused into the central nervous system  

Energy Technology Data Exchange (ETDEWEB)

D-aldosterone (5 ng/..mu..l/hr) was infused for six days into the area of the subcommissural organ (SCO) of conscious rats to test the hypothesis that the SCO and the adrenal zona glomerulosa are related functionally in a negative feedback manner. Aldosterone increased urinary sodium loss and the sodium/potassium ratio. These effects still occurred when cannulae were displaced caudally up to 1 mm from the targeted SCO area. Aldosterone decreased the cross-sectional area of the adrenal medulla without affecting chromaffin cell density. Adrenal content of corticosterone was increased. These effects were highly dependent upon proper cannula placement and were not observed when the tip of the cannula was not in contact with the cerebrospinal fluid of the pineal recess over the rostral two-thirds of the SCO. Aldosterone infused intracerebroventricularly (ivt) into a lateral ventricle had no effect on sodium excretion, adrenal corticosterone concentration or adrenal morphology. After the infusion of radiolabelled aldosterone into the SCO area, the majority of the radioactivity was restricted to an area about 1-2 mm in diameter from the SCO. Iron-dextran injected intraperiotoneally did not accumulate in the SCO; therefore, the blood-brain barrier is intact. It is concluded that the effects of aldosterone were dependent upon the area of the brain in which it was infused. Aldosterone increased sodium excretion by an action in the SCO and/or adjacent structures. A relationship between mineralocorticoids and the adrenal modulla mediated by the SCO is also postulated. With regard to the blood-brain and brain-CSF barriers, the SCO more closely resembles general brain tissue than other circumventricular organs.

Dundore, R.L.

1985-01-01

225

Studies on the subcommissural organ area in the rat: the effects aldosterone infused into the central nervous system  

International Nuclear Information System (INIS)

[en] D-aldosterone (5 ng/?l/hr) was infused for six days into the area of the subcommissural organ (SCO) of conscious rats to test the hypothesis that the SCO and the adrenal zona glomerulosa are related functionally in a negative feedback manner. Aldosterone increased urinary sodium loss and the sodium/potassium ratio. These effects still occurred when cannulae were displaced caudally up to 1 mm from the targeted SCO area. Aldosterone decreased the cross-sectional area of the adrenal medulla without affecting chromaffin cell density. Adrenal content of corticosterone was increased. These effects were highly dependent upon proper cannula placement and were not observed when the tip of the cannula was not in contact with the cerebrospinal fluid of the pineal recess over the rostral two-thirds of the SCO. Aldosterone infused intracerebroventricularly (ivt) into a lateral ventricle had no effect on sodium excretion, adrenal corticosterone concentration or adrenal morphology. After the infusion of radiolabelled aldosterone into the SCO area, the majority of the radioactivity was restricted to an area about 1-2 mm in diameter from the SCO. Iron-dextran injected intraperiotoneally did not accumulate in the SCO; therefore, the blood-brain barrier is intact. It is concluded that the effects of aldosterone were dependent upon the area of the brain in which it was infused. Aldosterone increased sodium excretion by an action in the SCO and/or adjacent structures. A relationship between mineralocorticoids and the adrenal modulla mediated by the SCO is also postulated. With regard to the blood-brain and brain-CSF barriers, the SCO more closely resembles general brain tissue than other circumventricular organs

1985-01-01

226

Rare, potentially fatal, poorly understood propofol infusion syndrome  

Directory of Open Access Journals (Sweden)

Full Text Available We present the case of a 7-year old boy with traumatic brain injury who received propofol during 38 h. Thirty-six hours after cessation of propofol infusion asystole occurred. After immediate mechanical and medical resuscitation, unreactive dilated pupils were observed. The following computed tomography scan revealed a generalized brain edema with transtentorial herniation. Prolonged bradyarrhythmia, rhabdomyolysis, and peracute renal failure were observed. Despite immediate craniectomy, barbiturate treatment, hemofiltration, and recovery of appropriate cardiac function, the patient died four days after discontinuation of propofol. In this case, metabolic acidosis, cardiac failure, rhabdomyolysis, and renal failure are in accordance with the symptoms of propofol infusion syndrome (PRIS), while seizure, brain edema, and transtentorial herniation could be caused by traumatic brain injury. However, it may be assumed that the entire clinical picture was caused by PRIS. This view could be explained by a common loss of function of ryanodine receptors in patients presenting with PRIS.

Eva Annen; Thierry Girard; Albert Urwyler

2012-01-01

227

Patterned polymer films via reactive silane infusion-induced wrinkling.  

UK PubMed Central (United Kingdom)

A method for simultaneously patterning and functionalizing thin poly(2-hydroxyethyl methacrylate) films through a reactive silane infusion based wrinkling is developed. Wrinkled patterns with tunable wavelengths on submicrometer size are easily produced over large area surfaces and can express a wide variety of chemical functional groups on the surface. The characteristic wavelength of wrinkling scales linearly with initial film thickness, in agreement with a gradationally swollen film model. Results from X-ray photoelectron spectroscopy confirm that the wrinkled film is composed of two layers: a gradient cross-linked top layer and a uniform un-cross-linked bottom layer. The surface chemical properties of wrinkles can be easily tuned by infusion of different functional silanes. Hierarchical wrinkled patterns with micro/nano structure can be achieved by combining wrinkling with other simple lithography methods. Wrinkled nanopatterns can be used as a mold to transfer the topology to a variety of other materials using nanoimprint lithography.

Li Y; Peterson JJ; Jhaveri SB; Carter KR

2013-04-01

228

[Infusion therapy complications in newborn and nursing infants  

UK PubMed Central (United Kingdom)

The case histories of 306 babies dying at the age under 6 months were analysed. All the babies were given medicinal and nutrient solutions mainly via the subclavical veins for different diseases. In the process of the infusion therapy complications were observed which were distributed into 5 groups: 1--traumatic injuries, 2--air embolism, 3--thrombosis, 4--diffuse hyalin thrombi predominantly in the lung vessels, 5--acute renal insufficiency (ARI). Formation of the hyalin thrombi appeared to be due to the damaging effect of the administered solutions on the vascular endothelium and changes in the properties of erythrocytes and blood plasma. In the development of ARI some importance is ascribed to infusion overloading of the structurally and functionally immature kidneys of young infants.

Eremeeva AS; Cherniavskaia NA

1978-01-01

229

Portable infusion pumps used for continuous regional analgesia: delivery rate accuracy and consistency.  

UK PubMed Central (United Kingdom)

BACKGROUND AND OBJECTIVES: Multiple benefits of postoperative perineural local anesthetic infusion have been shown including potent analgesia, decreased opioid requirements, and improved rehabilitation. Consequently, portable infusion pumps have been used with increasing frequency to provide perineural infusion for medically unsupervised ambulatory patients. We believe that the infusion rate accuracy and reliability of these pumps infusing potentially toxic doses of medication should be investigated independently. Therefore, we studied the flow-rate accuracy and consistency of various portable infusion pumps that have not been examined previously. METHODS: Using a computer/mass balance combination to record infusion rates, 6 pumps (3 electronic and 3 non electronic) were tested. Several factors that may influence pump performance were varied: temperature (ambient/skin), battery (replacement/addition), and catheter exchange (wound/perineural). RESULTS: Infusion rate accuracy differed significantly among the pumps, exhibiting flow rates within +/-15% of their expected rate for 55% to 99% of their infusion duration. Furthermore, the profiles (infusion rate over time) of the various pumps differed significantly depending on the pump power source. Although elastomeric pump infusion rate increased with an increase in temperature, battery life was a limiting factor for one of the electronic pumps. Substituting wound catheters with commonly used perineural catheters did not significantly alter infusion profile. CONCLUSIONS: Factors such as infusion rate accuracy and consistency, infusion profile, temperature sensitivity, and battery life affect the dose of medication administered by various portable pumps used for continuous regional analgesia. Health care providers should take these factors into consideration when choosing and using a portable infusion pump for local anesthetic administration.

Ilfeld BM; Morey TE; Enneking FK

2003-09-01

230

Dysphoria associated with methylphenidate infusion in borderline personality disorder.  

UK PubMed Central (United Kingdom)

Two patients with borderline personality disorder experienced dramatic dysphoric episodes after acute administration of intravenous methylphenidate in a double-blind manner. These dysphoric episodes were similar to those which occurred spontaneously under conditions of psychological stress. Case histories and the behavioral and cardiovascular effects of the infusions are described. The pharmacology of methylphenidate is discussed in order to elucidate possible mechanisms mediating the observed responses to this drug.

Lucas PB; Gardner DL; Wolkowitz OM; Cowdry RW

1987-12-01

231

Dysphoria associated with methylphenidate infusion in borderline personality disorder.  

Science.gov (United States)

Two patients with borderline personality disorder experienced dramatic dysphoric episodes after acute administration of intravenous methylphenidate in a double-blind manner. These dysphoric episodes were similar to those which occurred spontaneously under conditions of psychological stress. Case histories and the behavioral and cardiovascular effects of the infusions are described. The pharmacology of methylphenidate is discussed in order to elucidate possible mechanisms mediating the observed responses to this drug. PMID:3688282

Lucas, P B; Gardner, D L; Wolkowitz, O M; Cowdry, R W

1987-12-01

232

[Ketamine hydrochloride by continuous drip intravenous infusion in thoracic surgery  

UK PubMed Central (United Kingdom)

The Authors report an open trial on 50 patients anaesthetized with Ketamine hydrochloride, by continuous drip infusion progressively slowed, with the aid of Fentanil, in thoracic surgery. The proposed anaesthetic technique proved to be excellent as for as analgesia during and after operation as well cardiovascular stability and lackness of side effects is concerned. Recovery from anaesthesia was quick and extremely quite and free from side effects which are common in Ketamine anaesthesia.

Pietrobono P; Serafini G; Pagnin A; Venchi G

1980-08-01

233

[Ketamine hydrochloride by continuous drip intravenous infusion in thoracic surgery].  

Science.gov (United States)

The Authors report an open trial on 50 patients anaesthetized with Ketamine hydrochloride, by continuous drip infusion progressively slowed, with the aid of Fentanil, in thoracic surgery. The proposed anaesthetic technique proved to be excellent as for as analgesia during and after operation as well cardiovascular stability and lackness of side effects is concerned. Recovery from anaesthesia was quick and extremely quite and free from side effects which are common in Ketamine anaesthesia. PMID:7219752

Pietrobono, P; Serafini, G; Pagnin, A; Venchi, G

1980-08-01

234

Zoledronic acid infusion for prevention and treatment of osteoporosis  

Directory of Open Access Journals (Sweden)

Full Text Available John A SunyeczLaurel Highlands Ob/Gyn, Hopwood, Pennsylvania, USA and MenopauseRx, Inc., Uniontown, PA, USAAbstract: Osteoporotic fractures are associated with significant morbidity, reduced quality of life, increased mortality, and high health care costs. Bisphosphonates are standard therapy for treatment of osteoporosis. However, patient compliance and persistence with oral weekly or monthly bisphosphonate therapy are suboptimal and may lead to reduced effectiveness. Zoledronic acid (ZOL) is an intravenous bisphosphonate that is given once yearly for the treatment of osteoporosis via a medically supervised 15-minute infusion. This ensures compliance for a full 12 months. In clinical trials, an annual infusion of ZOL 5 mg has shown sustained efficacy in reducing hip and spine fractures in postmenopausal women with osteoporosis. It has also been shown to increase bone density in postmenopausal women with osteopenia (low bone mass) and in men with osteoporosis. Transient flu-like symptoms are the most common adverse effects following ZOL infusion, and these can generally be managed with acetaminophen. The availability of an intravenous bisphosphonate that ensures compliance over a long dosing interval may help to overcome barriers to efficacy resulting from poor long-term compliance with oral agents.Keywords: fractures, intravenous bisphosphonate, osteoporosis, zoledronic acid

John A Sunyecz

2010-01-01

235

Use of continuous infusion pumps during radiation treatment.  

UK PubMed Central (United Kingdom)

INTRODUCTION: Despite increasing chemoradiotherapy treatment, there is a paucity of information regarding the effects of radiation exposure on ambulatory infusion pumps used to deliver chemotherapy or other essential medications. The aim of this overview is to present the available evidence on this subject, heighten awareness within the clinical community, provide considerations for minimizing possible negative effects on patient care, and encourage the monitoring of infusion devices after exposure to radiation or electromagnetic interference. METHODS: Published literature was systematically searched using MEDLINE and EMBASE; gray literature was searched using Google and an environmental scan of relevant Web sites. A multidisciplinary working group reviewed the compiled evidence, and a draft of the document was sent to health professionals from various disciplines for an external review. RESULTS: Four reports and three manufacturer device alerts were identified that suggest a risk of pump malfunction as a result of radiation exposure. The estimated cumulative dose at which pump failure has been reported ranges from 28.5 to 42 Gy; however, additional clinical investigations should be undertaken. Pump relocation, pump shielding, and assessment of the pump after radiation exposure are most commonly suggested to minimize pump malfunction related to radiation exposure. A list of additional considerations is offered for those developing institution specific policies and procedures based on the available evidence and expert consensus. CONCLUSION: The varied and unpredictable results of radiation exposure on infusion devices suggest that additional testing should be carried out to determine the limits of dose exposure and to raise awareness around this patient safety issue.

Bak K; Gutierrez E; Lockhart E; Sharpe M; Green E; Costa S; Hertz S; Kaizer L; Whitton A; Warde P

2013-03-01

236

[Pediatric nosocomial bacteremia. Potential usefulness of culturing infusion liquids  

UK PubMed Central (United Kingdom)

Hospital-acquired bacteremia is a common cause of morbidity and mortality, mainly in pediatric units. In a 25 month retrospective study, we analyzed the blood cultures from the Hospital General Regional of the city of Leon, Guanajuato State, Mexico, in order to establish the causal agents of nosocomial bacteremia and infer some associations with contaminated intravenous infusion fluids. In addition we performed a two month study to culture the flasks and intravenous tubing used in our infusions. Five hundred and fifty one blood cultures drawn from August 1990 to September 1992 were analyzed. A total of 135 (24.5%) were positive, most of them (51.8%) with strains of the Klebsielleae tribe (SKT) (Klebsiella, Enterobacter, Serratia). The global incidence of bacteremia in the two year period was 4.3%. In the infusion study, 230 intravenous fluids were cultured, with 68 isolates (30%) most from the SKT tribe. A final consideration is made on the role that inadequate management of intravenous liquids could play in the development of endemic and epidemic nosocomial bacteremia in our hospital, and the eventual utility of making cultures of the i.v. liquids.

Macías-Hernández AE; Ortega-González P; Muñoz-Barrett JM; Hernández-Ramos I; Cal y Mayor-Turnbull I; Guerrero-Martínez FJ; Gollaz-Mares PG; Hernández-Hernández J; Ponce-de-León-Rosales S

1994-07-01

237

[Intraosseous infusions in pediatric life-threatening emergencies].  

Science.gov (United States)

As the bone marrow is a vascular tissue which cannot collapse, it may be used as a vascular access to treat life-threatening emergencies especially in children. Two cases reported here underline the value of this life-saving procedure. Both children were 9 months old, and were admitted for severe dehydration, having lost 15 and 10% of body weight respectively. All attempts to set up an intravenous infusion in a peripheral vein failed in both. The fontanelles were closed, and the central veins (internal jugular and subclavian veins) easily accessible, however collapsed. Intraosseous infusion was decided as a last ditch procedure. A 15-gauge Mallarmé's trocar was inserted at the proximal end of the tibia. In both children, this allowed rehydration to be carried out, and, in the second child, anticonvulsive and antibiotic therapy to be started. The intraosseous line was replaced, in the first child, at the third hour, by a conventional infusion line, set up by denudation, and in the second one, by a subclavian line. This technique has few contra-indications, and the complication rate is low. However, this technique should remain limited to a few indications only. PMID:8311352

Salino, D; Cottin, X; Bordenet, M

1993-01-01

238

Potential integration of gas infusion into a fuel cell system  

International Nuclear Information System (INIS)

'Full text:' An innovative gas infusion polymer electrolyte membrane (PEM) fuel cell prototype has been developed. PEM Fuel cell is operated under pressurized hydrogen gas and super oxygenated water. Gas infusion delivers super oxygenated water to the PEM fuel cell cathode at concentrations between 50 and 200 ppm, which overwhelms the limitation of 7 ppm concentration due to Henry's Law of the water within the cell. With adequate mixing, the water adjacent to the catalyst sites will have a higher concentration of oxygen than would be experienced in a cell running with the conventional method. The membrane is fully hydrated since the stack is constantly being fed with a liquid stream, which is recycled. Thermal management can be easily accomplished by liquid stream feed. The simple design of stack components, i.e. bipolar plate, gas diffusion layer (GDL) is studied. Application of gas infusion concepts in PEM fuel cell may alleviate cathode flooding and membrane dehydration problems in the absence of a humidifier. (author)

2004-01-01

239

Regional blood flow during continuous low-dose endotoxin infusion  

Energy Technology Data Exchange (ETDEWEB)

Escherichia coli endotoxin (ET) was administered to adult rats by continuous IV infusion from a subcutaneously implanted osmotic pump (Alzet). Cardiac output and regional blood flow were determined by the radiolabeled microsphere method after 6 and 30 hr of ET or saline infusion. Cardiac output (CO) of ET rats was not different from time-matched controls, whereas arterial pressure was 13% lower after 30 hr of infusion. After both 6 and 30 hr of ET, pancreatic blood flow and percentage of cardiac output were lower than in controls. Estimated portal venous flow was decreased at each time point, and an increased hepatic arterial flow (significant after 30 hr) resulted in an unchanged total hepatic blood flow. Blood flow to most other tissues, including epididymal fat, muscle, kidneys, adrenals, and gastrointestinal tract, was similar between treatments. Maintenance of blood flow to metabolically important tissues indicates that the previously reported alterations in in vitro cellular metabolism are not due to tissue hypoperfusion. Earlier observations of in vitro myocardial dysfunction, coexistent with the significant impairment in pancreatic flow, raise the possibility that release of a myocardial depressant factor occurs not only in profound shock but also under less severe conditions of sepsis and endotoxemia.

Fish, R.E.; Lang, C.H.; Spitzer, J.A.

1986-01-01

240

Intracranial hemodynamics during intravenous infusion of glyceryl trinitrate  

DEFF Research Database (Denmark)

The mechanisms of glyceryl trinitrate (GTN)-induced headache are not fully elucidated. In this study we administered GTN 0.5 microg/kg/min i.v. for 20 min in six healthy volunteers. Before, during and 60 min after the infusion, we investigated regional cerebral blood flow (rCBF), cerebral blood volume (CBV), both estimated with SPECT, and blood flow velocity (BFV) in the middle cerebral artery (MCA), measured with transcranial Doppler. Headache was scored on a numerical verbal rating (0-10) scale. rCBF was unchanged, CBV was slightly increased (13%) during GTN infusion, whereas BFV decreased both during (20%) and 60 min (15%) after GTN. Headache was short-lived and maximal during infusion. This discrepancy of time-effect curves for the effect of GTN on headache and dilatation of MCA indicates that MCA is most likely not the primary source of pain in GTN-induced headache. The time-effect curves for the effect of GTN on headache and on dilation of MCA differed markedly. This indicates that MCA is most likely not the primary source of pain in GTN-induced headache Udgivelsesdato: 2008/6

Iversen, H.K.; Holm, S.

2008-01-01

 
 
 
 
241

Local Intraarterial Thrombolysis: In Vitro Comparison of Various Infusion Catheters  

International Nuclear Information System (INIS)

[en] Purpose: Catheters are compared in vitro to evaluate the efficacy of thrombolysis during urokinase infusion within the thrombus. Methods: Six catheters were introduced individually into human thrombus within a stenotic flow model. Urokinase was infused continuously into the thrombus. To quantify the efficacy of thrombolysis, pressure gradients were recorded proximal and distal to the thrombus and during the course of infusion. Uniformity of lysis was assessed radiographically. Results: The fastest and most homogeneous thrombolysis was achieved with the EDM and the straight-flush catheter, shown by decreasing transthrombotic pressure gradients. All other catheter designs showed less homogeneous and delayed thrombolysis (p? 0.001, Friedmann-Test, Schaich-Hamerle). There was no significant difference in the efficacy of thrombus dissolution between the EDM and the straight-flush catheter (Wilcoxon, matched pairs, p> 0.7). Conclusion: The EDM catheter and the straight flush catheter achieved the most homogeneous and fastest thrombolysis, apparently due to the best urokinase distribution within the thrombus

1997-01-01

242

Fat Overload Syndrome After the Rapid Infusion of SMOFlipid Emulsion.  

Science.gov (United States)

Fat overload syndrome is a well-known complication of intravenous lipid emulsion therapy. It is characterized by headaches, fever, jaundice, hepatosplenomegaly, respiratory distress, and spontaneous hemorrhage. Other symptoms include anemia, leukopenia, thrombocytopenia, low fibrinogen levels, and coagulopathy. Several reports in the literature describe fat overload syndrome caused by rapid infusion of lipid emulsions, all with soybean-based lipid emulsions. We report fat overload syndrome in a 2-year-old girl with short bowel syndrome on home parenteral nutrition. Fat overload syndrome occurred as a result of accidental, very rapid infusion of a 20% soy oil, medium-chain triglyceride, olive and fish oil-based lipid emulsion (SMOFlipid) that showed the same complications seen with an earlier lipid emulsion (Intralipid). The patient was successfully treated with supportive care combining fluid infusion, transfusion of platelets, and substitution of serum albumin (0.5 g/kg/d) and fresh-frozen plasma (10 mL/kg). In the next couple of days, she received extra platelets, erythrocyte transfusion, and filgrastim (Neupogen; 5 µg/kg/d) due to a very low leukocyte count. To the best of our knowledge, this is the first case of fat overload syndrome caused by SMOFlipid emulsion described in the literature. PMID:23520135

Hojsak, Iva; Kolacek, Sanja

2013-03-21

243

Fat Overload Syndrome After the Rapid Infusion of SMOFlipid Emulsion.  

UK PubMed Central (United Kingdom)

Fat overload syndrome is a well-known complication of intravenous lipid emulsion therapy. It is characterized by headaches, fever, jaundice, hepatosplenomegaly, respiratory distress, and spontaneous hemorrhage. Other symptoms include anemia, leukopenia, thrombocytopenia, low fibrinogen levels, and coagulopathy. Several reports in the literature describe fat overload syndrome caused by rapid infusion of lipid emulsions, all with soybean-based lipid emulsions. We report fat overload syndrome in a 2-year-old girl with short bowel syndrome on home parenteral nutrition. Fat overload syndrome occurred as a result of accidental, very rapid infusion of a 20% soy oil, medium-chain triglyceride, olive and fish oil-based lipid emulsion (SMOFlipid) that showed the same complications seen with an earlier lipid emulsion (Intralipid). The patient was successfully treated with supportive care combining fluid infusion, transfusion of platelets, and substitution of serum albumin (0.5 g/kg/d) and fresh-frozen plasma (10 mL/kg). In the next couple of days, she received extra platelets, erythrocyte transfusion, and filgrastim (Neupogen; 5 µg/kg/d) due to a very low leukocyte count. To the best of our knowledge, this is the first case of fat overload syndrome caused by SMOFlipid emulsion described in the literature.

Hojsak I; Kolacek S

2013-03-01

244

Liposome distribution after intravenous and selective intraarterial infusion in dogs  

International Nuclear Information System (INIS)

In an effort to improve hepatic uptake of liposomes for drug delivery, empty vesicles were administered by means of selective arterial infusion. Negatively charged, multilamellar liposomes were labeled with technetium-99m and infused into healthy adult dogs. Each dog received 100 mg/m2 of lipid over 10 minutes at 2 mL/min. Liposomes were administered via the common hepatic artery after proximal occlusion of the gastroduodenal artery, via the cranial mesenteric artery, and via the cephalic vein. Distribution (liver, spleen, and lungs) was determined by computer-assisted external imaging techniques. On the average, after arterial infusion, 69.2% of the total activity was located in the liver, 3.6% in the spleen, 3.2% in the lungs, and 3.5% in the general circulation. Following venous injection, 50.7% of the radioactivity was found in the liver, 9.1% in the spleen, 8.6% in the lungs, and 6.7% in the peripheral blood. Once the liposomes entered the systemic circulation, they were cleared at the same rate (half-life beta = 21.5 hours) independent of their route of administration. Increased hepatic liposome uptake should translate into higher local and lower systemic liposomal drug levels.

1990-01-01

245

Phase II trial of vincristine infusion in acute leukemia.  

UK PubMed Central (United Kingdom)

A phase II trial of prolonged IV infusions of vincristine was conducted in 21 patients with refractory acute leukemia. Patients received 0.25-0.50 mg/m2 by infusion daily for 5 days after an initial 0.5-mg bolus. A partial response was observed in one of two patients with acute lymphoblastic leukemia. Of 14 patients with acute nonlymphoblastic leukemia, a complete response lasting for 2.5 months occurred in one patient and a partial response lasting 1.3 months was observed in a second. No objective responses were noted in five patients with blast crisis of chronic granulocytic leukemia. Nonhematologic toxicity was minimal and, when present, generally consisted of a feeling of weakness; constipation, mucositis, and areflexia were also observed. Hematologic toxicity consisted mainly of mild to moderate reduction of platelets in most patients; marked thrombocytopenia (less than 50,000/mm3) occurred in two patients whose pretreatment platelet count was greater than 100,000/mm3. Although generally well tolerated, prolonged infusion of vincristine appears to have limited activity in the treatment of refractory acute nonlymphoblastic leukemia and blast crisis of chronic granulocytic leukemia; further evaluation is needed in acute lymphoblastic leukemia refractory to conventional bolus injection.

Jackson DV Jr; Chauvenet AR; Callahan RD; Atkins JN; Trahey TF; Spurr CL

1985-01-01

246

Phase II trial of vincristine infusion in acute leukemia.  

Science.gov (United States)

A phase II trial of prolonged IV infusions of vincristine was conducted in 21 patients with refractory acute leukemia. Patients received 0.25-0.50 mg/m2 by infusion daily for 5 days after an initial 0.5-mg bolus. A partial response was observed in one of two patients with acute lymphoblastic leukemia. Of 14 patients with acute nonlymphoblastic leukemia, a complete response lasting for 2.5 months occurred in one patient and a partial response lasting 1.3 months was observed in a second. No objective responses were noted in five patients with blast crisis of chronic granulocytic leukemia. Nonhematologic toxicity was minimal and, when present, generally consisted of a feeling of weakness; constipation, mucositis, and areflexia were also observed. Hematologic toxicity consisted mainly of mild to moderate reduction of platelets in most patients; marked thrombocytopenia (less than 50,000/mm3) occurred in two patients whose pretreatment platelet count was greater than 100,000/mm3. Although generally well tolerated, prolonged infusion of vincristine appears to have limited activity in the treatment of refractory acute nonlymphoblastic leukemia and blast crisis of chronic granulocytic leukemia; further evaluation is needed in acute lymphoblastic leukemia refractory to conventional bolus injection. PMID:3965157

Jackson, D V; Chauvenet, A R; Callahan, R D; Atkins, J N; Trahey, T F; Spurr, C L

1985-01-01

247

Statistical Agglomeration: Peak Summarization for Direct Infusion Lipidomics.  

UK PubMed Central (United Kingdom)

MOTIVATION: Quantification of lipids is a primary goal in lipidomics. In direct infusion/injection (or shotgun) lipidomics, accurate downstream identification and quantitation requires accurate summarization of repetitive peak measurements. Imprecise peak summarization multiplies downstream error by propagating into species identification and intensity estimation. To our knowledge, this is the first analysis of direct infusion peak summarization in the literature. RESULTS: We present two novel peak summarization algorithms for direct infusion samples and compare them with an off-machine ad-hoc summarization algorithm as well as with the propriety Xcalibur algorithm. Our statistical agglomeration algorithm reduces peakwise error by 38% (m/z) and 44% (intensity) compared to the ad-hoc method over 3 data sets. Pointwise error is reduced by 23% (m/z). Compared to Xcalibur, our statistical agglomeration algorithm produces 68% less m/z error and 51% less intensity error on average on two comparable data sets. AVAILABILITY: The source code for Statistical Agglomeration and the data sets used are freely available for non-commercial purposes at https://github.com/optimusmoose/statistical_agglomeration. Modified Bin Aggolmeration is freely available in MSpire, an open source mass spectrometry package at https://github.com/princelab/mspire/. CONTACT: 2robsmith@gmail.com, jtprince@chem.byu.edu.

Smith R; Anthonymuthu TS; Ventura D; Prince JT

2013-07-01

248

Statistical agglomeration: peak summarization for direct infusion lipidomics.  

UK PubMed Central (United Kingdom)

MOTIVATION: Quantification of lipids is a primary goal in lipidomics. In direct infusion/injection (or shotgun) lipidomics, accurate downstream identification and quantitation requires accurate summarization of repetitive peak measurements. Imprecise peak summarization multiplies downstream error by propagating into species identification and intensity estimation. To our knowledge, this is the first analysis of direct infusion peak summarization in the literature. RESULTS: We present two novel peak summarization algorithms for direct infusion samples and compare them with an off-machine ad hoc summarization algorithm as well as with the propriety Xcalibur algorithm. Our statistical agglomeration algorithm reduces peakwise error by 38% mass/charge (m/z) and 44% (intensity) compared with the ad hoc method over three datasets. Pointwise error is reduced by 23% (m/z). Compared with Xcalibur, our statistical agglomeration algorithm produces 68% less m/z error and 51% less intensity error on average on two comparable datasets. AVAILABILITY: The source code for Statistical Agglomeration and the datasets used are freely available for non-commercial purposes at https://github.com/optimusmoose/statistical_agglomeration. Modified Bin Aggolmeration is freely available in MSpire, an open source mass spectrometry package at https://github.com/princelab/mspire/. CONTACT: 2robsmith@gmail.com or jtprince@chem.byu.edu SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

Smith R; Anthonymuthu TS; Ventura D; Prince JT

2013-10-01

249

Safety of iron polymaltose given as a total dose iron infusion.  

UK PubMed Central (United Kingdom)

An audit of the in-hospital safety and tolerability of 401 infusions of iron polymaltose in 386 patients has shown no cases of anaphylaxis or other cardiorespiratory compromise. The infusion was terminated prematurely because of adverse events in six patients (1.6%). No adverse events occurred within the first 15 min of the infusion. Premedication (in 24%) was not associated with fewer adverse events. Fear of anaphylaxis should not inhibit the use of total dose iron infusion and the practices of premedication and of medical supervision during the first 15 min of the infusion should be abandoned.

Newnham E; Ahmad I; Thornton A; Gibson PR

2006-10-01

250

Safety of iron polymaltose given as a total dose iron infusion.  

Science.gov (United States)

An audit of the in-hospital safety and tolerability of 401 infusions of iron polymaltose in 386 patients has shown no cases of anaphylaxis or other cardiorespiratory compromise. The infusion was terminated prematurely because of adverse events in six patients (1.6%). No adverse events occurred within the first 15 min of the infusion. Premedication (in 24%) was not associated with fewer adverse events. Fear of anaphylaxis should not inhibit the use of total dose iron infusion and the practices of premedication and of medical supervision during the first 15 min of the infusion should be abandoned. PMID:16958647

Newnham, E; Ahmad, I; Thornton, A; Gibson, P R

2006-10-01

251

Rapid infusion with rituximab: short term safety in systemic autoimmune diseases  

DEFF Research Database (Denmark)

To describe the incidence, types and severity of adverse events, related to an accelerated regime of rituximab infusion in patients with various autoimmune diseases. Fifty-four patients with systemic autoimmune disease, to be treated with 1,000 mg of rituximab twice 2 weeks apart, participated. Pre-medication (oral prednisolone, anti-histamine and paracetamol) was administered 1-4 h before infusion start. The first infusion was administered over a period of 195 min. The second infusion over a period of 90 min. Any adverse events were classified using the Clinical Trials Classification of Adverse Events (CTCAE) v. 3.0. Ten patients (18.5%) experienced at least one infusion-related reaction (IRR) ever. The first infusion was associated with reactions in 4 CTCAE categories of which rhinitis were the most frequent. The CTCAE severity grading showed six patients (11.1%) had a grade 1 reaction. One patient (1.8%) had grade 2 events on both infusions and two patients (3.6%) had a grade 3 event on both infusions. RA patients more often had an infusion-related reaction (IRR) (9.2%) than the rest. The types of IRR were mostly of allergic or angio-oedematic nature. In practise, the rapid infusion was an easy to use regime and the second infusion is of time sparing significance to health professionals. No unexpected side effects were observed in relation to the accelerated regime.

Larsen, Janni Lisander; Jacobsen, Soren

2011-01-01

252

Geophysical control of water infusion into rock strata for reducing rock burst hazards  

Energy Technology Data Exchange (ETDEWEB)

Presented is a review of seismic, geoelectric, seismoacoustic and microseismic methods for control of water infusion used for rock burst prevention in Poland. The seismic method consists in measuring propagation of transverse or longitudinal waves before and after water infusion into a coal seam. The CS-4G seismic detection system (made in Poland) is used. Geoelectric method consists in determining effects of water infusion on electric conductivity of coal. The Terrameter system made by the ABEM company (Sweden) is used. Seismoacoustic monitoring supplies valuable information on dynamics of fissure formation in coal and rock strata during water infusion. The reviewed control methods are used in the Wujek mine for assessment of water infusion efficiency. Conditions of water infusion such as borehole dimensions and distribution, water pressure, and infusion time are described. Evaluation results are shown in 8 schemes and diagrams. On the basis of experiments carried out in the Wujek mine criteria for assessment of water infusion efficiency are determined. Three classes are used: extremely efficient water infusion, efficient infusion, and water infusion with low efficiency. 6 references.

Dubinski, J.; Szot, M.

1983-07-01

253

The analgesic and sedative properties of dexmedetomidine infusion after uvulopalatopharyngoplasty  

Directory of Open Access Journals (Sweden)

Full Text Available Background: Dexmedetomidine is an alpha2 - adrenergic agonist with sedative and analgesic properties. This study aimed to investigate if the use of continuous dexmedetomidine infusion with i.v. morphine patient-controlled analgesia (PCA) could improve postoperative analgesia while reducing opioid consumption and opioid-related side effects. Materials & methods: In this prospective randomized, double-blinded, controlled study, 24 patients with obstructive sleep apnea syndrome undergoing uvulopalatopharyngoplasty were assigned to two groups. Group D received a loading dose of dexmedetomidine 1µg kg¯¹ i.v., 30 min before the anticipated end of surgery, followed by a continuous infusion at a rate of 0.6 µg kg¯¹ hr¯¹ for 24 hr. Group P received a volume-matched bolus and infusion of placebo. In both groups, postoperative pain was initially controlled by i.v. morphine titration and then PCA with morphine. Cumulative PCA morphine consumption, pain intensities, sedation scores, cardiovascular and respiratory variables and narcotic-related adverse effects were recorded for 48 h after operation. Results: Extubation time was significantly prolonged in dexmedetomidine group (16±7 vs. 11±6 min p=0.074) in the placebo group. Visual analogue scale scores were significantly greater during the first 2h after tracheal extubation in the placebo group than in the dexmedetomidine group. The time to first analgesic request was significantly longer in the dexmedetomidine group than in the placebo group (21±11 vs. 9±4min; p=0.002). Compared with group P, patients in group D required 52.7% less morphine by PCA during the first 24h postoperative period, whereas levels of sedation were similar between the 2 groups at each observational time point. Fewer patients in group D experienced nausea and vomiting than those in group P (P< 0.05). There was no bradycardia, hypotension, or respiratory depression. Continuous dexmedetomidine infusion may be a useful anesthetic adjuvant for patients who are susceptible to narcotic-induced respiratory depression. Conclusion: Continuous infusion of dexmedetomidine for pain relief after uvulopalatopharyngoplasty significantly reduces the amount of PCA morphine used by the patients postoperatively without affecting their ventilatory parameters and was associated with fewer morphine-related side effects. This novel drug could become a useful anesthetic adjuvant for patients with obstructive sleep apnea who are susceptible to narcotic-induced respiratory depression

W.Abd El Megid ¹* and Ahmed M. Nassar

2009-01-01

254

Acute infusion reactions to chemotherapeutic drugs: a single institute experience.  

UK PubMed Central (United Kingdom)

PURPOSE: Treating cancer often involves the use of chemotherapeutic agents. Due to the growing incidence of cancer worldwide and the expanding number of treatment options, it is important to understand the risks of adverse events associated with these treatments. In this study, we monitored the occurrence of acute infusion reactions in an outpatient chemotherapy center from April 2011 to April 2012. METHODS: For patients who developed infusion reactions, the causative drug, the dose and number of treatments received, the onset time of the reaction, the duration of the reaction, blood pressure, pulse, level of oxygen saturation during the reaction, and other symptoms were recorded. The severity of reactions was determined in accordance with NCI toxicity criteria. A reaction was considered as grade 1-2 (mild-moderate) if the patient experienced flushing, rash, fever, tremor, dyspnea, rigor, and mild hypotension. Symptoms such as severe hypotension, bronchospasm, cardiac dysfunction and anaphylaxis, requiring therapeutic intervention, were classified as severe, grade 3-4 reactions. RESULTS: Of the 2213 patients receiving chemotherapy during the study period, 138 (62%) developed an infusion reaction to the treatment. Among 138 patients most commonly treated types of carcinoma included breast (39.2%), lung (17.8%), colorectal (10%), and ovarian (8.5%) cancers. Docetaxel administration resulted in the largest number of infusion reactions, though most reactions were mild to moderate and did not require the cessation of treatment. Patients with mild to moderate reactions (89.2%) were able to continue treatment, while those who developed severe reactions (10.8%) could not continue treatment with the same agent. CONCLUSION: Although severe reactions are rare, the incidence of mild to moderate reactions against taxanes, platinum compounds, and monoclonal antibodies is quite high. Clinical symptoms do not vary widely among the agents, though the onset time of symptoms does vary. While reactions against platinum agents were of type 1 anaphylactic reactions, reactions against taxanes and monoclonal antibodies during the first infusion and in the following minutes suggest the activation of different mechanisms.

Muallaoglu S; Disel U; Mertsoylu H; Besen A; Karadeniz C; Taner Sumbul A; Abali H; Ozyilkan O

2013-01-01

255

RF tumor ablation with internally cooled electrodes and saline infusion: what is the optimal location of the saline infusion?  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Radiofrequency ablation (RFA) of tumors by means of internally cooled electrodes (ICE) combined with interstitial infusion of saline may improve clinical results. To date, infusion has been conducted through outlets placed on the surface of the cooled electrode. However, the effect of infusion at a distance from the electrode surface is unknown. Our aim was to assess the effect of perfusion distance (PD) on the coagulation geometry and deposited power during RFA using ICE. Methods Experiments were performed on excised bovine livers. Perfusion distance (PD) was defined as the shortest distance between the infusion outlet and the surface of the ICE. We considered three values of PD: 0, 2 and 4 mm. Two sets of experiments were considered: 1) 15 ablations of 10 minutes (n ? 4 for each PD), in order to evaluate the effect of PD on volume and diameters of coagulation; and 2) 20 additional ablations of 20 minutes. The effect of PD on deposited power and relative frequency of uncontrolled impedance rises (roll-off) was evaluated using the results from the two sets of experiments (n ? 7 for each PD). Comparisons between PD were performed by analysis of variance or Kruskal-Wallis test. Additionally, non-linear regression models were performed to elucidate the best PD in terms of coagulation volume and diameter, and the occurrence of uncontrolled impedance rises. Results The best-fit least square functions were always obtained with quadratic curves where volume and diameters of coagulation were maximum for a PD of 2 mm. A thirty per cent increase in volume coagulation was observed for this PD value compared to other values (P Conclusion Saline perfusion at around 2 mm from the electrode surface while using an ICE in RFA improves deposition of energy and enlarges coagulation volume.

Burdío Fernando; Berjano Enrique J; Navarro Ana; Burdío José M; Güemes Antonio; Grande Luis; Sousa Ramón; Subiró Jorge; Gonzalez Ana; Cruz Ignacio; Castiella Tomás; Tejero Eloy; Lozano Ricardo; de Gregorio Miguel A

2007-01-01

256

Rapid vascular glucose uptake via enzyme-assisted subcutaneous infusion: enzyme-assisted subcutaneous infusion access study.  

UK PubMed Central (United Kingdom)

BACKGROUND: Enzyme-assisted subcutaneous infusion (EASI), with subcutaneous human recombinant hyaluronidase pretreatment, may offer an alternative to standard intravenous (IV) access. OBJECTIVES: This study's objectives were to assess paramedic (Emergency Medical Technician-Paramedic [EMTP])-placed EASI access in volunteers to determine (1) feasibility of EMTP EASI access placement; (2) subject/EMTP ratings of placement ease, discomfort, and overall EASI vs IV preference; and (3) speed of intravascular uptake of EASI infusate. METHODS: Twenty adults underwent 20-gauge IV placement by 4 EMTPs, receiving a 250-mL maximal-rate IV bolus of normal saline. Next, each subject received in the other arm a 20-gauge EASI access line (with 1-mL injection of 150 U of human recombinant hyaluronidase), through which was infused 250 mL D5NS (1 g glucose was labeled with stable tracer 13C). Blood draws enabled gas chromatography/mass spectrometry (GC/MS) assessment of 13C-glucose uptake. Intravenous access and EASI access were compared for time parameters and subject/EMTP ratings. Data were analyzed with median and interquartile range, Kruskal-Wallis testing, Fisher exact test, and regression (GC/MS data). RESULTS: Intravenous access and EASI access were successful in all 20 subjects. Compared with EASI access (all placed in <15 seconds), IV access took longer; but the 250-mL bolus was given more quickly via IV access. EMTPs rated EASI easier to place than IV; pain ratings were similar for IV and EASI. The GC/MS showed intravascular uptake at all time points. CONCLUSIONS: Enzyme-assisted subcutaneous infusion is faster and easier to initiate than IV access; intravascular absorption of EASI-administered fluids begins within minutes.

Soremekun OA; Shear ML; Patel S; Kim GJ; Biddinger PD; Parry BA; Yialamas MA; Thomas SH

2009-11-01

257

Mixing in the human carotid artery during carotid drug infusion studied with PET  

Energy Technology Data Exchange (ETDEWEB)

The safety and efficacy of drug infusion into the carotid artery require adequate mixing of the infused solution with carotid blood. Using positron emission tomography (PET), we studied the mixing of solutions infused into the human carotid artery in seven patients by analyzing the distribution of (15O)H2O infused into the carotid artery and by vein. At four infusion rates ranging from 0.5 to 10 ml/min, the variability in distribution averaged 16.5-17.8% among the pixels in a large volume of interest, without dependence on the infusion rate. The overall correlation between (15O)H2O influx with arterial infusion and (15O)H2O influx with venous injection was 0.78-0.82 at the four infusion rates, with no trend toward higher correlations at the faster infusion rates. The distribution into the anterior, middle, and posterior cerebral artery territories differed from distribution throughout the entire carotid territory by an average of 6.2-9.6% at the four infusion rates, with no trend toward smaller differences at the faster infusion rates. Infusions performed into a vinyl tube simulating the carotid artery indicated that at 0.5 ml/min, the velocity of fluid exiting the catheter makes no apparent contribution to mixing. We conclude that with infusions at the carotid bifurcation, mixing in the human carotid artery is complete or nearly complete over a wide range of infusion rates. The mixing appears to result from the patterns of blood flow within the artery, and not from jet effects at the catheter tip.

Junck, L.; Koeppe, R.A.; Greenberg, H.S. (Univ. of Michigan, Ann Arbor (USA))

1989-10-01

258

[Normoglycemic control by artificial pancreas in patients with pancreatic diabetes or with primary diabetes mellitus--analysis of patterns of insulin infusion and nocturnal glucose infusion].  

UK PubMed Central (United Kingdom)

It has been reported that patients with pancreatic diabetes (PD) show nocturnal hypoglycemia frequently when compared to patients with diabetes mellitus (DM). Present study was carried out to compare patterns of insulin infusion and nocturnal glucose infusion under normoglycemic control in between PD and DM. Eleven PD patients whose onset of diabetes mellitus appeared after the onset of chronic pancreatitis (PD group), and 10 patients with insulin-dependent diabetes mellitus without pancreatic disease (DM group) were studied. To control the blood glucose level, a closed loop insulin delivery system (Biostator GCIIS, Miles Laboratories) was used. 24 hours infused amount of insulin in PD group was not different from that in DM group, while patterns of insulin infusion in both groups were different. Thus, most of 24 h-infused insulin were given during 2 hours postprandial period in PD group, while in DM group, insulin was given mostly as a basal infusion. In this study glucose infusion occur in a state of hypoglycemia (less than 90 mg/dl). 7 of 11 in PD group and 2 of 10 in DM group had glucose infusion which mostly occurred at a night time.

Yoshida Y; Koizumi M; Abe N; Ishizuka J; Sanoyama K; Goto Y

1989-03-01

259

Safe and tolerable one-hour pamidronate infusion for multiple myeloma patients  

Directory of Open Access Journals (Sweden)

Full Text Available Dimitrios Chantzichristos, Andréasson Björn, Johansson PeterDepartment of Internal Medicine, Uddevalla Hospital, Uddevalla, SwedenBackground: Once a month, patients with multiple myeloma received an infusion of bisphosphonates, principally to reduce osteoclastic bone resorption. Recommended infusion time for pamidronate is 2 hours in the US and 4 hours in Europe because of its potential nephrotoxicity. From 2003, a 90 mg infusion of pamidronate was provided over 1 hour to patients with no pre-existing renal impairment, in the Daily Care Unit at Uddevalla Hospital.Method: Retrospective analysis of the renal deterioration, serum calcium, and adverse effects in patients with multiple myeloma treated with 1-hour pamidronate 90 mg infusion from January 2003 to April 2007.Results: Seventy-nine patients provided valuable data. A total number of 846 infusions were given and the median number of infusion to each patient was 11. Significant creatinine elevation was seen in 7 patients (8.9%), after 19 infusions (2.2%). Renal deterioration occurred in 5 of these 7 patients, which was related to progress of the myeloma or opportunistic infections. Prevalence of infusion-related events was 0.8% and the mean total S-Ca was 0.05 mmol/L lower than the baseline.Conclusion: Few events of renal deterioration, hypocalcemia, or other adverse effects resulted from a 1-hour pamidronate 90 mg infusion for multiple myeloma patients with no pre-existing renal impairment.Keywords: bisphosphonates, pamidronate, multiple myeloma, infusion time

Dimitrios Chantzichristos; Andréasson Björn; Johansson Peter

2008-01-01

260

Prevention of drug delivery disturbances during continuous intravenous infusion: An in vitro study on a new multi-lumen infusion access device.  

UK PubMed Central (United Kingdom)

OBJECTIVE: Stopping and restarting carrier fluid flow and performing simultaneous drug infusions can lead to hazardous disturbances in drug delivery. The present study was designed to assess in vitro whether using a multi-lumen infusion access device could prevent noradrenaline disturbances. STUDY DESIGN: In vitro laboratory work. METHODS: Two infusion devices were studied: a standard device with a four-port manifold and a 150cm extension line and a nine-lumen infusion device (Edelvaiss-Multiline(®)) with eight accesses connected to nine separate lumens in a single tube of 150cm: seven accesses connected to seven peripheral lumens and one for the carrier fluid access connected to two lumens. Two experimental protocols of noradrenaline infusion were made: (a) drug flow rate change and (b) stop-and-go carrier fluid flows. Two parameters were studied: drug mass flow rate and flow change efficiency (FCE) calculated from the ratio of the area under the experimental mass flow rate curve to the area under the theoretical instantaneous mass flow rate curve. RESULTS: Variations in noradrenaline mass flow rate were more rapid with the Edelvaiss-Multiline(®) when the noradrenaline infusion rate was increased or decreased. FCE was significantly different from one infusion device to the other during both noradrenaline flow rate increase (standard vs. nine-lumen: 58% vs. 84%; P=0.008) and decrease (175% vs. 108%; P=0.008). Decreased drug delivery after stopping carrier fluid flow (standard vs. nine-lumen: 21% vs. 98%; P=0.008) and sudden temporary increases on resumption (253% vs. 103%; P=0.008) were reduced in magnitude and duration when using the Edelvaiss-Multiline(®) with a significant difference in FCE between the two infusion devices. CONCLUSIONS: Using the nine-lumen infusion device reduces drug delivery disturbances during continuous intravenous infusion.

Foinard A; Décaudin B; Barthélémy C; Debaene B; Odou P

2013-09-01

 
 
 
 
261

Effect of magnesium infusion on thoracic epidural analgesia.  

UK PubMed Central (United Kingdom)

INTRODUCTION: Patients of lung volume reduction surgery (LVRS) having an ASA status III or more are likely to be further downgraded by surgery to critical levels of pulmonary function. AIM: To compare the efficacy of thoracic epidural block with (0.125%) bupivacaine, fentanyl combination and (0.125%) bupivacaine, fentanyl combination with adjunctive intravenous magnesium infusion for the relief of postoperative pain in patients undergoing LVRS. METHODS: Patients were operated under general anesthesia. Thirty minutes before the anticipated completion of skin closure in both groups, (Group A and Group B) 7 ml of (0.125%) bupivacaine calculated as 1.5 ml/thoracic segment space for achieving analgesia in dermatomes of T4, T5, T6, T7, and T8 segments, along with fentanyl 50 ?g (0.5 ml), was administered through the catheter, activating the epidural block, and the time was noted. Thereafter, in patients of Group A, magnesium sulfate injection 30 mg/kg i.v. bolus was followed by infusion of magnesium sulfate at 10 mg/kg/hr and continued up to 24 hours. Group B was treated as control. RESULTS AND ANALYSIS: A significant increase in the mean and maximum duration of analgesia in Group A in comparison with Group B (P<0.05) was observed. Total epidural dose of fentanyl and bupivacaine required in Group A was significantly lower in comparison with Group B in 24 hours. DISCUSSION: Requirement of total doses of local anesthetics along with opioids could be minimized by magnesium infusion; therefore, the further downgradation of patients of LVRS may be prevented. CONCLUSION: Intravenous magnesium can prolong opioid-induced analgesia while minimizing nausea, pruritus, and somnolence.

Gupta SD; Mitra K; Mukherjee M; Roy S; Sarkar A; Kundu S; Goswami A; Sarkar UN; Sanki P; Mitra R

2011-01-01

262

Effect of magnesium infusion on thoracic epidural analgesia  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction: Patients of lung volume reduction surgery (LVRS) having an ASA status III or more are likely to be further downgraded by surgery to critical levels of pulmonary function. Aim: To compare the efficacy of thoracic epidural block with (0.125%) bupivacaine, fentanyl combination and (0.125%) bupivacaine, fentanyl combination with adjunctive intravenous magnesium infusion for the relief of postoperative pain in patients undergoing LVRS. Methods: Patients were operated under general anesthesia. Thirty minutes before the anticipated completion of skin closure in both groups, (Group A and Group B) 7 ml of (0.125%) bupivacaine calculated as 1.5 ml/thoracic segment space for achieving analgesia in dermatomes of T4, T5, T6, T7, and T8 segments, along with fentanyl 50 ?g (0.5 ml), was administered through the catheter, activating the epidural block, and the time was noted. Thereafter, in patients of Group A, magnesium sulfate injection 30 mg/kg i.v. bolus was followed by infusion of magnesium sulfate at 10 mg/kg/hr and continued up to 24 hours. Group B was treated as control. Results and Analysis: A significant increase in the mean and maximum duration of analgesia in Group A in comparison with Group B (PDiscussion: Requirement of total doses of local anesthetics along with opioids could be minimized by magnesium infusion; therefore, the further downgradation of patients of LVRS may be prevented. Conclusion: Intravenous magnesium can prolong opioid-induced analgesia while minimizing nausea, pruritus, and somnolence.

Gupta Sampa; Mitra Koel; Mukherjee Maitreyee; Roy Suddhadeb; Sarkar Aniruddha; Kundu Sudeshna; Goswami Anupam; Sarkar Uday; Sanki Prakash; Mitra Ritabrata

2011-01-01

263

Prostacyclin release following endoperoxide analogue infusion in the intact dog.  

UK PubMed Central (United Kingdom)

We examined the systemic and coronary hemodynamic responses after infusion of an endoperoxide analogue U 46,619 in anesthetized dogs and related the hemodynamic effects to the release of thromboxane A2 (TXA2) and prostacyclin (PGI2). Immediately after U 46,619 infusion, increases in mean arterial and left ventricular end-diastolic pressures (LVEDP) occurred, whereas coronary and aortic blood flows were unchanged. Calculated vascular resistances in the systemic and coronary vascular beds increased significantly. At 3-5 min after infusion, mean arterial pressure and LVEDP spontaneously decreased and vascular resistances also declined, whereas coronary and aortic blood flows were unchanged. Simultaneously measured plasma TXB2 and 6-keto-PGF1 alpha (stable hydrolysis metabolites of TXA2 and PGI2, respectively) increased in the femoral and coronary arterial blood samples in conjunction with the vasoconstrictor effects. At 3-5 min, plasma 6-keto-PGF1 alpha concentrations showed a further increase, whereas TXB2 concentrations slightly decreased, suggesting release of PGI2 as a possible mechanism of vasodilation. To examine this possibility, nine dogs were treated with cyclooxygenase inhibitors (aspirin or indomethacin) and given U 46,619. In these animals neither vasoconstrictor nor vasodilator effects were observed. Plasma TXB2 and 6-keto-PGF1 alpha concentrations also did not increase after U 46,619. These data show that the vasoconstrictor and platelet aggregatory agent U 46,619 results in PGI2 release in the dog. Release of PGI2 may be a protective and autoregulatory mechanism in the canine systemic and coronary vascular beds.

Mehta J; Nichols WW; Goldman R

1984-02-01

264

Carotid artery mixing with diastole-phased pulsed drug infusion  

Energy Technology Data Exchange (ETDEWEB)

Focal injury to the brain or retina is a frequent complication of drug delivery to the internal carotid artery (ICA) and may be due to poor mixing of the drug with blood at the infusion site. Rhesus monkeys were studied to determine whether phased drug delivery during diastole from a modified pulsatile angiographic injector would improve drug mixing in vivo. A radiolabeled flow tracer, carbon-14-iodoantipyrine (/sup 14/C-IAP), was injected into the ICA of three monkeys in 80-msec pulses, each ending at least 50 msec before the end of local diastole. Local isotope concentration in the brain was determined by quantitative autoradiography. The ratio of highest to lowest concentration was 1.86 +/- 0.26 (mean +/- standard deviation) in the frontoparietal cortex, 1.65 +/- 0.42 in the frontoparietal white matter, 1.89 +/- 0.28 in the temporal cortex, and 1.39 +/- 0.17 in the basal ganglia. These results were similar to recordings in three control animals that received intravenous /sup 14/C-IAP to demonstrate complete drug mixing (1.37 +/- 0.12, 1.41 +/- 0.11, 1.70 +/- 0.08, 1.22 +/- 0.24, respectively), and contrasted to findings in five animals which received continuous intracarotid infusions to demonstrate standard ICA drug delivery (4.54 +/- 2.07, 2.94 +/- 1.45, 5.43 +/- 3.57, 3.60 +/- 2.90, respectively). Pulsed intra-arterial infusion during diastole provides a technically simple method for improving intravascular drug mixing, and results in drug delivery to tissue capillaries that is proportional to blood flow.

Saris, S.C.; Shook, D.R.; Blasberg, R.G.; Dedrick, R.L.; Doppman, J.L.; Bankiewicz, K.S.; Blacklock, J.B.; Oldfield, E.H.

1987-11-01

265

Estimation of theophylline clearance during intravenous aminophylline infusions.  

Science.gov (United States)

The utility of predicting theophylline clearance (CL) from two serum concentrations obtained during continuous intravenous aminophylline infusion was examined in 16 stable, adult patients. Blood for theophylline measurement was obtained 0, 6, and 12 h after starting infusions and, thereafter, at 12-h intervals. EMIT was used to assay samples in multiple runs as they were obtained. Later, each sample was reassayed by EMIT within a single run. Bayesian least-squares regression and the algebraic method of Chiou were used to predict CL using the 0,6 and 0,12 h concentrations. "Actual" CL was measured by nonlinear least-squares regression of all concentrations obtained during prolonged infusions. Prediction bias and precision were assessed by calculating mean percent error (PCE) and mean absolute percent error (APCE), respectively. A three-way repeated-measures ANOVA was used to examine the effect of the method of CL prediction, assay procedure, and time interval between samples on PCE and APCE. Bayesian predictions were less biased and slightly more precise than Chiou predictions. The assay procedure had no effect on bias but precision was improved using a single-assay run. Predictions were less biased and more precise with 0,12 h versus 0,6 h data. Serum samples for theophylline measurement should be obtained after initiating constant intravenous aminophylline and again 8-12 h later in stable, adult patients. Prediction of CL with either of the concentration-based methods studied will then allow safe and rapid adjustment of dosage to achieve therapeutic serum concentrations. PMID:4020626

Gilman, T M; Muir, K T; Jung, R C; Walberg, C B

1985-05-01

266

A naturalistic glyceryl trinitrate infusion migraine model in the rat  

DEFF Research Database (Denmark)

Glyceryl trinitrate (GTN) infusion is a reliable method to provoke migraine-like headaches in humans. Previous studies have simulated this human model in anaesthetized or in awake rodents using GTN doses 10,000 times higher than used in humans. The relevance of such toxicological doses to migraine is not certain. Anaesthesia and low blood pressure caused by high GTN doses both can affect the expression of nociceptive marker c-fos. Therefore, our aim was to simulate the human GTN migraine model in awake rats using a clinically relevant dose.

Ramachandran, Roshni; Bhatt, Deepak Kumar

2012-01-01

267

Two key strategies for teaching prevention: specialized course and infusion.  

UK PubMed Central (United Kingdom)

Prevention is taught only rarely in counseling and counseling psychology curricula. Failure to teach it suggests that graduates may be less likely to conduct prevention. In this article, we describe two key strategies for addressing this problem, where prevention is being taught through (a) required courses, and (b) infusion within existing courses. Four training programs, two examples of each mode, are presented from the University of Cincinnati, Pennsylvania State University, Boston College, and the University of Minnesota. We describe the processes involved in developing and implementing these key pedagogical strategies that lead, we intend, to broadened application.

Conyne RK; Newmeyer MD; Kenny M; Romano JL; Matthews CR

2008-09-01

268

Two key strategies for teaching prevention: specialized course and infusion.  

Science.gov (United States)

Prevention is taught only rarely in counseling and counseling psychology curricula. Failure to teach it suggests that graduates may be less likely to conduct prevention. In this article, we describe two key strategies for addressing this problem, where prevention is being taught through (a) required courses, and (b) infusion within existing courses. Four training programs, two examples of each mode, are presented from the University of Cincinnati, Pennsylvania State University, Boston College, and the University of Minnesota. We describe the processes involved in developing and implementing these key pedagogical strategies that lead, we intend, to broadened application. PMID:18807193

Conyne, Robert K; Newmeyer, Mark D; Kenny, Maureen; Romano, John L; Matthews, Constance R

2008-09-19

269

The Case for Infusing Quantitative Literacy into Introductory Geoscience Courses  

Directory of Open Access Journals (Sweden)

Full Text Available We present the case for introductory geoscience courses as model venues for increasing the quantitative literacy (QL) of large numbers of the college-educated population. The geosciences provide meaningful context for a number of fundamental mathematical concepts that are revisited several times in a single course. Using some best practices from the mathematics education community surrounding problem solving, calculus reform, pre-college mathematics and five geoscience/math workshops, geoscience and mathematics faculty have identified five pedagogical ideas to increase the QL of the students who populate introductory geoscience courses. These five ideas include techniques such as: place mathematical concepts in context, use multiple representations, use technology appropriately, work in groups, and do multiple-day, in-depth problems that place quantitative skills in multiple contexts. We discuss the pedagogical underpinnings of these five ideas and illustrate some ways that the geosciences represent ideal places to use these techniques. However, the inclusion of QL in introductory courses is often met with resistance at all levels. Faculty who wish to include quantitative content must use creative means to break down barriers of public perception of geoscience as qualitative, administrative worry that enrollments will drop and faculty resistance to change. Novel ways to infuse QL into geoscience classrooms include use of web-based resources, shadow courses, setting clear expectations, and promoting quantitative geoscience to the general public. In order to help faculty increase the QL of geoscience students, a community-built faculty-centered web resource (Teaching Quantitative Skills in the Geosciences) houses multiple examples that implement the five best practices of QL throughout the geoscience curriculum. We direct faculty to three portions of the web resource: Teaching Quantitative Literacy, QL activities, and the 2006 workshop website - Infusing Quantitative Literacy into Introductory Geoscience Courses. These portions of the website are designed to give geoscience faculty the resources they need to infuse quantitative content into their entry-level courses, thereby building the QL of the students who enroll. The infusion of QL in the introductory geoscience classroom allows faculty to realistically represent the quantitative nature of the science to the students who may need it most. Ultimately, the inclusion of pedagogically sound quantitative activities and exercises will serve to increase QL of our educated citizenry.

Jennifer M. Wenner; Eric M. Baer; Cathryn A. Manduca; R. Heather Macdonald; Samuel Patterson; Mary Savina

2009-01-01

270

Crystallogenic Properties of a Biological Fluid in Chemical Agent Infusion  

Directory of Open Access Journals (Sweden)

Full Text Available There have been studied cocrystallization peculiarities of blood serum with urea water solutions of different concentration (30; 15; 7.5; 3.75 and 1.725%) in the ratio 1:1 compared to a proper structure-forming biosubstrate considering the uremia initial level. The urea dose-dependent infusion has been stated to alter the crystallogenic properties of biological fluid up to a full suppression of its proper crystallization in high concentrations of the compound (15 and 30% solutions), however, the shift expression is determined by initial endogenous urea content in blood.

A.K. Martusevich; Zh.G. Simonova

2011-01-01

271

Wave motions in unbounded poroelastic solids infused with compressible fluids  

CERN Multimedia

Looking at rational solid-fluid mixture theories in the context of their biomechanical perspectives, this work aims at proposing a two-scale constitutive theory of a poroelastic solid infused with an inviscid compressible fluid. The propagation of steady-state harmonic plane waves in unbounded media is investigated in both cases of unconstrained solid-fluid mixtures and fluid-saturated poroelastic solids. Relevant effects on the resulting characteristic speed of longitudinal and transverse elastic waves, due to the constitutive parameters introduced, are finally highlighted and discussed.

Quiligotti, S; dell'Isola, F

2010-01-01

272

Infusing protective factors for children in foster care.  

UK PubMed Central (United Kingdom)

This article looks at an example of infusing protective factors into a child welfare system. Focusing on Illinois and its state child welfare agency, the article reviews some of the research on the relationship between risk behaviors and protective factors of traumatized youth. Next, it looks at adapting treatment and evidence-based early intervention practices to local child welfare settings. These interventions are placed in the wider context of a state plan to enhance protective factors. The article reviews how the state and local plans have been influenced by federal policies and how the Illinois experience might help refine future policy.

Griffin G; McEwen E; Samuels BH; Suggs H; Redd JL; McClelland GM

2011-03-01

273

Subeschar antibiotic infusion in the treatment of burn wound infection.  

UK PubMed Central (United Kingdom)

In a reproducible infected rat burn model, subeschar infusion of antibiotics failed to protect the animals from death via burn wound invasion excepting those animals receiving carbenicillin. Subcutaneous injection of maximal doses of carbenicillin at a distance from the burn wound protected these animals equally well. Some advantage was defined for the subeschar route of administration with suboptimal doses of carbenicillin. More important is the fact that propective selection of an effective antibiotic could not be made on the basis of in vitro antibiotic sensitivity tests.

McManus WF; Mason AD Jr; Pruitt BA Jr

1980-12-01

274

[Acute pain at tumor recurrence site induced by vinorelbine infusion].  

UK PubMed Central (United Kingdom)

We present a case of vinorelbine (VNR)-induced acute tumor pain. Oral control-release oxycodone was administered for cancer pain by iliac bone metastasis. In chemotherapy by combined use of VNR and gemcitabine, severe pain in groin, thigh and hip occurred immediately after infusion of VNR. Oral rapid-release oxycodone was administered but the pain lasted half an hour and then resolved spontaneously. In the following course of chemotherapy by same regimen, pre-medication of rapid-release oxycodone did not prevent the pain.

Shibahara H; Hiramatsu Y

2013-07-01

275

[Acute pain at tumor recurrence site induced by vinorelbine infusion].  

Science.gov (United States)

We present a case of vinorelbine (VNR)-induced acute tumor pain. Oral control-release oxycodone was administered for cancer pain by iliac bone metastasis. In chemotherapy by combined use of VNR and gemcitabine, severe pain in groin, thigh and hip occurred immediately after infusion of VNR. Oral rapid-release oxycodone was administered but the pain lasted half an hour and then resolved spontaneously. In the following course of chemotherapy by same regimen, pre-medication of rapid-release oxycodone did not prevent the pain. PMID:23917136

Shibahara, Hiroaki; Hiramatsu, Yoshinori

2013-07-01

276

Assessment of the effectiveness of standardized infusion devices for healthcare management  

Directory of Open Access Journals (Sweden)

Full Text Available Since standardization is an important safety measure in healthcare systems, it is essential to systematically assess the effects of introducing new and increasingly complex medical equip-ment, such as infusion devices. In this study, we compared the effects of standardized polyvinyl chloride (PVC)-free closed-system integrated infusion devices with conventional infusion de-vices. Specifically, we assessed the safety, work efficiency, user-friendliness, and cost effec-tiveness of these devices. Compared with con-ventional infusion devices, integrated PVC-free infusion devices were more expensive to pur-chase and dispose, but were safer and more user-friendly and efficient. Although it would be preferable to use standardized infusion devices in all hospital departments, their cost may limit their application to departments that use high-risk treatments, where they would be most beneficial.

Shio Sugita; Hideko Aida; Aya Okada; Hiroyuki Kobayashi

2011-01-01

277

Transition to an elastomeric infusion pump in home care: an evidence-based approach.  

Science.gov (United States)

A fatal overdose of a chemotherapeutic agent delivered to a patient via an electronic infusion device served as a stark reminder of the risks that infusion therapy poses to patients and health care providers and as the impetus for a strategy to optimize safe and efficient delivery of home infusion therapy. The Academic Center for Evidence-Based Practice Star Model of Knowledge Transformation was used as the evidence-based framework for the implementation of a portable infusion pump that supports home infusion of high-risk medications, leading to increased patient and caregiver satisfaction. Evaluation of this implementation supports the use of an elastomeric infusion device for a high-risk therapy. PMID:22498484

Broadhurst, Daphne

278

Transition to an elastomeric infusion pump in home care: an evidence-based approach.  

UK PubMed Central (United Kingdom)

A fatal overdose of a chemotherapeutic agent delivered to a patient via an electronic infusion device served as a stark reminder of the risks that infusion therapy poses to patients and health care providers and as the impetus for a strategy to optimize safe and efficient delivery of home infusion therapy. The Academic Center for Evidence-Based Practice Star Model of Knowledge Transformation was used as the evidence-based framework for the implementation of a portable infusion pump that supports home infusion of high-risk medications, leading to increased patient and caregiver satisfaction. Evaluation of this implementation supports the use of an elastomeric infusion device for a high-risk therapy.

Broadhurst D

2012-05-01

279

Consequences of delayed pump infusion line change in patients with type 1 diabetes mellitus treated with continuous subcutaneous insulin infusion.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To systematically investigate the effect of lack of adherence to the recommended change in insulin pump infusion line use beyond 48 h and determine whether the type of insulin made a difference. RESEARCH DESIGN AND METHODS: This was a double-blind, randomized, crossover trial with 20 patients with diabetes mellitus I using insulins aspart and lispro without a line change for up to 100 h. Using retrospective continuous glucose monitoring, we analyzed the average glucose over the day. Changes in serum 1,5-anhydroglucitol, carboxymethyllysine, and free 15-F(2t) isoprostane were also studied. RESULTS: From Day 2 to Day 5 of the pump line use, the daily average glucose level increased from 122.7 to 163.9 mg/dl (P<.05), fasting glucose from 120.3 to 154.5 mg/dl (P<.05), postprandial glucose from 114.6 to 172.1 mg/dl (P<.05), and the daily maximum glucose from 207.7 to 242.8 dl (P<.05 for the trend). Time period that the glucose was >180 mg/dl increased from 14.5% to 38.3% (P<.05). Loss of control occurred despite increase in total daily insulin dose from 48.5+/-11.8 to 55.3+/-17.9 U (P=.05). There was no difference in loss of control between insulin types, and biomarkers measured did not change significantly. CONCLUSIONS: The insulin pump infusion should be changed every 48 h in patients using continuous subcutaneous insulin infusion (CSII), to avoid loss of glycemic control. In the short-term, this loss of glycemic control has no impact on oxidative stress and glycation.

Thethi TK; Rao A; Kawji H; Mallik T; Yau CL; Christians U; Fonseca V

2010-03-01

280

Does prolonged ?-lactam infusions improve clinical outcomes compared to intermittent infusions? A meta-analysis and systematic review of randomized, controlled trials  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background The emergence of multi-drug resistant Gram-negatives (MDRGNs) coupled with an alarming scarcity of new antibiotics has forced the optimization of the therapeutic potential of available antibiotics. To exploit the time above the minimum inhibitory concentration mechanism of ?-lactams, prolonging their infusion may improve outcomes. The primary objective of this meta-analysis was to determine if prolonged ?-lactam infusion resulted in decreased mortality and improved clinical cure compared to intermittent ?-lactam infusion. Methods Relevant studies were identified from searches of MEDLINE, EMBASE, and CENTRAL. Heterogeneity was assessed qualitatively, in addition to I2 and Chi-square statistics. Pooled relative risks (RR) and 95% confidence intervals (CI) were calculated using Mantel-Haenszel random-effects models. Results Fourteen randomized controlled trials (RCTs) were included. Prolonged infusion ?-lactams were not associated with decreased mortality (n= 982; RR 0.92; 95% CI:0.61-1.37) or clinical cure (n = 1380; RR 1.00 95% CI:0.94-1.06) compared to intermittent infusions. Subgroup analysis for ?-lactam subclasses and equivalent total daily ?-lactam doses yielded similar results. Most studies had notable methodological flaws. Conclusions No clinical advantage was observed for prolonged infusion ?-lactams. The limited number of studies with MDRGNs precluded evaluation of prolonged infusion of ?-lactams for this subgroup. A large, multicenter RCT with critically ill patients infected with MDRGNs is needed.

Tamma Pranita D; Putcha Nirupama; Suh Yong D; Van Arendonk Kyle J; Rinke Michael L

2011-01-01

 
 
 
 
281

THE ROLE OF INTRAVENOUS AMINO ACID INFUSION IN OLIGOHYDRAMNIOS  

Directory of Open Access Journals (Sweden)

Full Text Available Oligohydramnios means the fetus is in a compromised condition. Ante partum amniotic fluid index (A.F.I.) assessment is one of the reliable, good predictor and standard technique for assessment of fetal well-being in antenatal period. In the present study 25 cases of Oligohydramnios in the third trimester were given intravenous amino acid in 1000cc of 10% fructodex drip on 1st day and the amino acid infusion drip in 500 ml of 10% fructodex daily till 6 days. After that biweekly till patient deliver or till term. There were 4 cases of severe Oligohydramnios and 21 cases of moderate Oligohydramnios at the time of their first visit. After amino acid infusion therapy, on repeat ultrasonography, 9 (36%) cases patients with moderate Oligohydramnios had improved amniotic fluid index (AFI) to normal whereas two patients with severe Oligohydramnios had improved A.F.I. to moderate Oligohydramnios and remaining 12 and two patients of moderate and severe Oligohydramnios group patients did not show any changes in A.F.I. Maximum cases delivered vaginally.

Ritu Gupta et al

2012-01-01

282

Continuous intrathecal baclofen infusion for spasticity of cerebral origin.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To determine if continuous intrathecal baclofen infusion (CIBI) would provide continuous relief of spasticity in patients with spasticity of cerebral origin, especially children with cerebral palsy. DESIGN: Prospective, unblinded trial, before and after CIBI. SETTING: Children's Hospital of Pittsburgh (Pa). PATIENTS: Thirty-seven patients, 5 to 27 years of age, with spasticity of cerebral origin. INTERVENTION: Continuous intrathecal baclofen infusion for 3 to 48 months. MAIN OUTCOME MEASURES: Muscle tone, range of motion, upper extremity timed tasks, activities of daily living (ADLs). RESULTS: Six and 12 months after CIBI, muscle tone was significantly decreased in the upper (P = .04) and lower (P = .001) extremities. There was a significant relationship between baclofen dosage and muscle tone in the upper (P = .02) and lower (P = .001) extremities. Hamstring motion, upper extremity function, and ADLs were significantly improved in 25 patients who were capable of self-care. CONCLUSION: Spasticity of cerebral origin can be effectively treated with CIBI. Because baclofen dosages can be titrated for the desired clinical response, CIBI is particularly useful for patients who need some spasticity to stand and ambulate.

Albright AL; Barron WB; Fasick MP; Polinko P; Janosky J

1993-11-01

283

Brief report: Mechanism of extravasation of infused stem cells.  

Science.gov (United States)

In order for bloodborne stem cells to be effective in tissue regeneration, cells must cross vessel walls and enter the parenchyma. Although such transmigration does occur, the mechanism remains elusive. Leukocytes invade tissue by diapedesis; stem cells are commonly assumed to do likewise, but evidence is lacking. Cardiac-derived regenerative cells and multicellular cardiospheres (CSPs) were infused into the coronary vessels of rat hearts. Serial histology revealed a novel mechanism of cell transmigration, "active vascular expulsion," which underlies the extravasation of infused cells and cell aggregates. In this mechanism, the vascular barrier undergoes extensive remodeling, while the cells themselves are relatively passive. The mechanism was confirmed in vivo by serial intravital microscopy of CSP extravasation in a dorsal skin flap model. Integrins and matrix metalloproteinases play critical roles in active vascular expulsion. In vitro models revealed that active vascular expulsion is generalizable to other stem cell types and to breast cancer cells. Recognition of active vascular expulsion as a mechanism for transvascular cell migration opens new opportunities to enhance the efficacy of vascularly delivered cell therapy. PMID:23135922

Cheng, Ke; Shen, Deliang; Xie, Yucai; Cingolani, Eugenio; Malliaras, Konstantinos; Marbán, Eduardo

2012-12-01

284

Legal aspects of infusion practice: trends and issues.  

UK PubMed Central (United Kingdom)

Inserting intravenous catheter lines, giving injections, handling and discarding sharps, and assisting with sterile procedures.these, and many other high-risk procedures are an ordinary part of the daily practice regimen for many nurses, especially those specializing in infusion therapy. In addition, nurses engaged in an infusion practice are subject to exposure to bloodborne diseases that can prove to be career-ending and fatal. Despite the frequency with which these high-risk procedures are performed, developing case law reveals the perils associated with these activities. Courts around the country have dealt with a number of issues that may be of interest to nurses who start IV catheters, give injections, handle and discard sharps, and assist with sterile procedures. In addition, a growing number of cases are focusing on the rights and responsibilities of healthcare professionals and patients who have been exposed to blood and blood products. This article will explore a number of those issues: the distinction that courts make between nonclinicians and professionals who suffer needlestick injuries or who are exposed to blood and blood products; the intersection between needlestick injuries and exposure to blood and blood products and the worker's compensation system; product liability causes of action; and emotional distress causes of action filed by healthcare professionals and others. It is hoped that this information will be instructive, and that the issues discussed herein will be considered when practice expectations are identified. If that happens, the clinical environment can be safer for nurses and patients.

Monarch K

2002-11-01

285

Antioxidant capacity of teas and herbal infusions: polarographic assessment.  

UK PubMed Central (United Kingdom)

Hydrogen peroxide scavenging (HPS) activity of unfermented (green, yellow, and white), partially fermented (oolong), and completely fermented (black) tea ( Camellia sinensis ), maté ( Ilex paraguariensis ), and various herbal infusions, as well as individual compounds (flavan-3-ols, flavonols, cinnamic and benzoic acids, and methylxanthines), was assessed by recently developed direct current (DC) polarographic assay. Correlations of tea and herbal infusion HPS activity with total phenolic content determined using the Folin-Ciocalteu assay (FC-GAE) (0.81 and 0.93), ferric reducing/antioxidant power (FRAP) (0.97 and 0.92), 1,1-diphenyl-2-picrylhydrazyl (DPPH) (0.77 and 0.80), and 2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) scavenging (0.86 and 0.86) were statistically significant. Correlations between relative antioxidant capacity index (RACI), calculated by assigning all applied assays equal weight, and HPS (0.98), FRAP (0.97), ABTS (0.89), and DPPH (0.89) confirmed DC polarographic assay reliability when applied individually. Correlation analysis, ANOVA, and Levene and Tukey's HSD tests unequivocally confirmed this reliable, rapid, and low-cost assay validity, clearly demonstrating its advantages over spectrophotometric assays applied.

Gorjanovi? S; Komes D; Pastor FT; Belš?ak-Cvitanovi? A; Pezo L; He?imovi? I; Sužnjevi? D

2012-09-01

286

Morphine infusions into the rostrolateral periaqueductal gray affect maternal behaviors  

Scientific Electronic Library Online (English)

Full Text Available Abstract in english It is well established that morphine inhibits maternal behaviors. Previous studies by our group have shown activation of the rostrolateral periaqueductal gray (rlPAG) upon inhibition-intended subcutaneous injections of morphine. In this context, we demonstrated that a single naloxone infusion into the rlPAG, following this opioid-induced inhibition, reactivated maternal behaviors. Since these data were obtained by using peripheral morphine injections, the present study wa (more) s designed to test whether morphine injected directly into the rlPAG would affect maternal behaviors. Our hypothesis that morphine acting through the rlPAG would disrupt maternal behaviors was confirmed with a local infusion of morphine. The mothers showed shorter latency for locomotor behavior to explore the home cage (P = 0.049). Inhibition was especially evident regarding retrieving (P = 0.002), nest building (P = 0.05) and full maternal behavior (P = 0.023). These results support the view that opioidergic transmission plays a behaviorally meaningful inhibitory role in the rostrolateral PAG.

Moura, L.M.; Canteras, N.S.; Sukikara, M.H.; Felicio, L.F.

2010-09-01

287

Plasma Calcium, Inorganic Phosphate and Magnesium During Hypocalcaemia Induced by a Standardized EDTA Infusion in Cows  

Directory of Open Access Journals (Sweden)

Full Text Available The intravenous Na2EDTA infusion technique allows effective specific chelation of circulating Ca2+ leading to a progressive hypocalcaemia. Methods previously used were not described in detail and results obtained by monitoring total and free ionic calcium were not comparable due to differences in sampling and analysis. This paper describes a standardized EDTA infusion technique that allowed comparison of the response of calcium, phosphorus and magnesium between 2 groups of experimental cows. The concentration of the Na2EDTA solution was 0.134 mol/l and the flow rate was standardized at 1.2 ml/kg per hour. Involuntary recumbency occurred when ionised calcium dropped to 0.39 – 0.52 mmol/l due to chelation. An initial fast drop of ionized calcium was observed during the first 20 min of infusion followed by a fluctuation leading to a further drop until recumbency. Pre-infusion [Ca2+] between tests does not correlate with the amount of EDTA required to induce involuntary recumbence. Total calcium concentration measured by atomic absorption remained almost constant during the first 100 min of infusion but declined gradually when the infusion was prolonged. The concentration of inorganic phosphate declined gradually in a fluctuating manner until recumbency. Magnesium concentration remained constant during infusion. Such electrolyte responses during infusion were comparable to those in spontaneous milk fever. The standardized infusion technique might be useful in future experimental studies.

Mellau LSB; Jørgensen RJ; Enemark JMD

2001-01-01

288

Uterine infusion of melatonin or melatonin receptor antagonist alters ovine feto-placental hemodynamics during midgestation.  

UK PubMed Central (United Kingdom)

Dietary melatonin supplementation from mid- to late gestation increases umbilical artery blood flow and causes disproportionate fetal growth. Melatonin receptors have been described throughout the cardiovascular system; however, there is a paucity of data on the function of placental melatonin receptors. The objectives of the current experiment were to determine fetal descending aorta blood flow, umbilical artery blood flow, and placental and fetal development following a 4-wk uterine infusion of melatonin (MEL), melatonin receptor 1 and 2 antagonist (luzindole; LUZ), or vehicle (CON) from Day 62 to Day 90 of gestation. After 4 wk of infusion, umbilical artery blood flow and umbilical artery blood flow relative to placentome weight were increased (P < 0.05) in MEL- versus CON- and LUZ-infused dams. Fetal descending aorta blood flow was increased (P < 0.05) in MEL- versus CON- and LUZ-infused dams, while fetal descending aorta blood flow relative to fetal weight was increased in MEL- versus CON-infused dams and decreased in LUZ- versus CON-infused dams. Following the 4-wk infusion, we observed an increase in placental efficiency (fetal-placentome weight ratio) in MEL- versus LUZ-infused dams. The increase in umbilical artery blood flow due to chronic uterine melatonin infusion is potentiated by an increased fetal cardiac output through the descending aorta. Moreover, melatonin receptor antagonism decreased fetal descending aorta blood flow relative to fetal weight. Therefore, melatonin receptor activation may partially mediate the observed increase in fetal blood flow following dietary melatonin supplementation.

Lemley CO; Camacho LE; Vonnahme KA

2013-08-01

289

Radiographic and Histologic Study After Infusion of Contrast Media into Rabbit Submandibular Gland  

Energy Technology Data Exchange (ETDEWEB)

50 submandibular glands of rabbits were examined historadiologically after infusion with normal and over volumes of physiologic saline and 5 radiographic contrast media. The results were as follows: 1. All water soluble contrast media showed similar radiographic contrasts and absorbed about 5 minutes after infusion except Telebrix 30 which took 30 minutes in both normal and overfilled glands. 2. Lipid soluble medium, Lipiodol UF had excellent radiographic contrast and could be seen on the radiograms even after 24 hours after infusion. 3. Salivary glands infused with physiologic saline didn't show any histologic changes except slight duct dilation right after infusion. 4. Telebrix 30 caused mild to moderate duct dilation and inflammation at immediate and 24 hours after infusion which was more severe in overfilled glands. At 7 days after infusion, there were mild to moderate fibrosis of the gland and areas of necrosis was seen in overfilled glands. 5. Hypaque 60% showed similar histologic reactions to Telebrix 30 except more severe tissue destruction at 7 days after infusion. 6. Urografin 60% showed mildest histologic changes among the media used in the study. 7. Biliscopin had mild duct dilation which returned to normal after 7 days but there were moderate inflammation and tissue necrosis at that time. 8. Lipiodol UF showed severe duct dilation with numerous vacuoles and there were tissue fibrosis at 7 days after infusion but no tissue necrosis was seen.

Nah, Kyung Soo; Park, Tae Won [Department of Oral Radiology, Seoul National University, Seoul (Korea, Republic of)

1990-02-15

290

An experimental study on renal arterial and parenchymal change caused by selective renal infusion of epinephrine  

Energy Technology Data Exchange (ETDEWEB)

Selective infusion of the epinephrine into the renal artery has been used in the field of the diagnostic and the therapeutic radiology for correct diagnosis and effective treatment, respectively. However, administration of overdose of epinephrine may cause serious complication, renal infarction. The study was undertaken to evaluate the sequential change of renal arterial constrictive effect of selective infusion of epinephrine into renal artery and to determine the critical doses of epinephrine producing irreversible renal infarct. A total of 25 rabbits are used, which are divided into 5 groups. Under the general anesthesia is made the selective infusion of various doses of epinephrine into the right renal artery of the rabbits. At the various time interval during and after the epinephrine infusion, renal angiography was done, and 24 hrs. later, gross and microscopic findings of the kidney were observed. The results are as follows; 1. Vasoconstriction of renal artery occurred within 2 mins. infusion, and maximum effect within 5 mins. 2. It seems that there is correlation between the amount of infused epinephrine and the time taken to recover from constriction of renal artery. 3. When epinephrine is infused into the renal artery in the rate of 1 ug/min., renal infarct is not noticed below the level of 10 mins., but correlation between the amount of infused epinephrine and the frequency of renal infarct occurs above 20 mins. infusion.

Jeon, Seok Chol; Yeon, Kyung Mo; Han, Man Chung [College of Medicine, Seoul National University, Seoul (Korea, Republic of)

1981-06-15

291

An experimental study on renal arterial and parenchymal change caused by selective renal infusion of epinephrine  

International Nuclear Information System (INIS)

Selective infusion of the epinephrine into the renal artery has been used in the field of the diagnostic and the therapeutic radiology for correct diagnosis and effective treatment, respectively. However, administration of overdose of epinephrine may cause serious complication, renal infarction. The study was undertaken to evaluate the sequential change of renal arterial constrictive effect of selective infusion of epinephrine into renal artery and to determine the critical doses of epinephrine producing irreversible renal infarct. A total of 25 rabbits are used, which are divided into 5 groups. Under the general anesthesia is made the selective infusion of various doses of epinephrine into the right renal artery of the rabbits. At the various time interval during and after the epinephrine infusion, renal angiography was done, and 24 hrs. later, gross and microscopic findings of the kidney were observed. The results are as follows; 1. Vasoconstriction of renal artery occurred within 2 mins. infusion, and maximum effect within 5 mins. 2. It seems that there is correlation between the amount of infused epinephrine and the time taken to recover from constriction of renal artery. 3. When epinephrine is infused into the renal artery in the rate of 1 ug/min., renal infarct is not noticed below the level of 10 mins., but correlation between the amount of infused epinephrine and the frequency of renal infarct occurs above 20 mins. infusion.

1981-01-01

292

Pathways of infusate loss during convection-enhanced delivery into the putamen nucleus.  

UK PubMed Central (United Kingdom)

BACKGROUND: New strategies aiming to treat Parkinson's disease, such as delivery of trophic factors via protein infusion or gene transfer, depend upon localized intracerebral infusion, mainly into the putamen nucleus. Convection-enhanced delivery (CED) has been proposed as a method to improve intracerebral distribution of therapies. Yet analysis of controversial results during the clinical translation of these strategies suggests that intracerebral misdistribution of infusate may have affected the outcomes by limiting the amount of treatment into the target region. Objectives: This study aimed to identify possible pathways of infusate loss and their relative impact in the success of targeted CED into the postcommissural ventral putamen nucleus. MetHODS: Thirteen adult macaque monkeys received intraputaminal CED infusions of 100 µl of 2.0 mM gadoteridol and bromophenol blue (0.16 mg/ml) solution at a rate of 1.0 µl/min under intraoperative magnetic resonance imaging (MRI) guidance. Quantitative maps of infusate concentration were computed at 10-min intervals throughout the procedure in a 3-Tesla MRI scanner. The fraction of tracer lost from the putamen as well as the path of loss were evaluated and quantified for each infusion. RESULTS: All injections (total 22) were successfully placed in the ventral postcommissural putamen nucleus. Four major paths of infusate loss from the putamen were observed: overflow across putamen boundaries, perivascular flow along large blood vessels, backflow along the inserted catheter and catheter tract leakage into the vacated catheter tract upon catheter removal. Overflow loss was observed within the first 30 µl of infusion in all cases. Measurable tracer loss following the path of an artery out of the putamen was observed in 15 cases, and in 8 of these cases, the loss was greater than 10% of infusate. Backflow that exited the putamen was observed in 4 cases and led to large loss of infusate (80% in 1 case) into the corona radiata. Loss into the vacated catheter tract amounted only to a few microliters. CONCLUSIONS: Our analysis demonstrates that after controlling for targeting, catheter type, infusion rate and infusate, the main issues during surgical planning are the identification of appropriate infusate volume that matches the target area, as well as mapping the regional vasculature as it may become a pathway for infusate loss. Most importantly, these results underscore the significance of presurgical planning for catheter placement and infusion, and the value of imaging guidance to ensure targeting accuracy.

Brady ML; Raghavan R; Alexander A; Kubota K; Sillay K; Emborg ME

2013-01-01

293

Investigation on the pancreatic and stomach secretion in pigs by means of continuous infusion of 14C-amino acids  

International Nuclear Information System (INIS)

[en] 2 pigs received a barley-soya bean meal diet and another 2 a casein-wheat starch diet. The specific radioactivity (SR = dpm/?mol) of leucine and phenylalanine in the TCA soluble fraction of plasma and in the TCA soluble and TCA precipitable fractions of pancreatic juice and of digesta leaving the stomach was determined during 6 hours of intravenous infusion of 14C-leucine and 14C-phenylalanine. At the end of the infusion the SR of both amino acids in both fractions of several tissues was measured and used for calculations of the rate of tissue protein synthesis. The results are that mainly amino acids derived from the extracellular space were used for synthesis that the process of synthesis, concentration and secretion of secretory proteins requires in pigs 120 to 180 minutes, and that TCA soluble amino acids in pancreatic juice are not free amino acids per se, but originate from processing of presecretory proteins. In the duodenal digesta labelled proteins appeared 3 to 4 hours after the beginning of the infusion. Both, secretion of proteins by the pancreas and by the stomach seemed to be more stimulated after feeding the barley-soya diet than the casein-starch diet. Of all tissues, the SR of amino acids in proteins was highest in the pancreas. However, proteins secreted by the pancreas were 3 to 4 times higher labelled than those retained in the tissue. The range of the fractional rate of protein synthesis was calculated for the sections of the gastrointestinal tract, the liver and skeletal muscles and discussed with other findings. (author)

1983-01-01

294

The Efficacy of Postoperative Wound Infusion with Bupivacaine for Pain Control after Cesarean Delivery: Randomized Double Blind Clinical Trial  

Directory of Open Access Journals (Sweden)

Full Text Available Objective: This study investigated the efficacy of bupivacaine wound infusion for pain control and opioid sparing effect after cesarean delivery."nMaterials and methods: We conducted a randomized double blind, placebo controlled clinical trial on 60 parturients undergoing cesarean section at a university hospital in Tehran. Patients were randomized to receive a pump infusion system that was filled with either 0.25% bupivacaine or equal volume of distilled water. A catheter was placed above the fascia and connected to electronic pump for 24 hours. Postoperative analog pain scores and morphine consumption were assessed at 6, 12 and 24 hours. Also time interval to first ambulation, length of hospitalization, complications and patient satisfaction were recorded. Data were analyzed using the SPSS software and P < 0.05 was considered statistically significant. Mann-Whitney u-test, student t-test and chi-square were used. "nResults: There were no differences in patient demographics and length of hospitalization and patient-generated resting pain scores between the two groups. Pain scores after coughing and leg raise during the first 6 postoperative hours were significantly less in the Bupivacaine group (P<0.001). The total dose of morphine consumption during the 24 hours study period was 2.5 ± 2.5 mg vs. 7.3 ± 2.7 mg for the bupivacaine and control groups, respectively (P<0.001). Compared with the control group, time to first ambulation was shorter in the bupivacaine group (11± 5h vs. 16 ± 4h) (P< 0.01). "nConclusion: Bupivacaine wound infusion was a simple and safe technique that provides effective analgesia and reduces morphine requirements after cesarean delivery.

Azin Alavi; Saghar Salehpour; Mahnaz Narimani

2007-01-01

295

Systematic review of oxytocin dosing at caesarean section.  

UK PubMed Central (United Kingdom)

We undertook a systematic review to determine the optimal dose of oxytocin after elective caesarean section or caesarean section in labouring women. We identified seven trials. These trials raise questions about the use of high dose (10 international units; IU) or moderate dose (5 IU) oxytocin in both settings and provide evidence that lower doses are equally effective but associated with significantly fewer side-effects. For elective caesarean section, a slow 0.3 to 1 IU bolus of oxytocin over one minute, followed by an infusion of 5 to 10 IU.h(-1) for four hours represents an evidence-based approach to dosing for women at low risk of postpartum haemorrhage. For the labouring parturient a slow 3 IU bolus of oxytocin, followed by an infusion of 5 to 10 IU.h(-1) for four hours is supported by limited evidence. These doses represent a starting point in the control of postpartum haemorrhage after caesarean section and do not reduce the need for mandatory active observation of the clinical situation, to detect situations that require additional doses of oxytocin or other uterotonic drugs. These doses of oxytocin minimise the risk of adverse haemodynamic changes as well as the unpleasant side-effect of nausea.

Stephens LC; Bruessel T

2012-03-01

296

Increased adriamycin levels in hepatic implants of rabbit Vx-2 carcinoma from regional infusion.  

UK PubMed Central (United Kingdom)

Regional infusion chemotherapy for the treatment of primary or secondary hepatic cancer should allow delivery of a higher drug concentration to the tumor with decreased systemic exposure when compared with systemic therapy. Fifteen rabbits, each implanted with two hepatic Vx-2 tumors, were treated with infusion of Adriamycin (3 mg/kg and 7.5 muCi of [14C]Adriamycin) through the hepatic artery (n = 5), portal vein (n = 5), and a systemic vein (n = 5) at 20 mg/min. 99Tc-labeled macroaggregated albumin flow images documented specific hepatic perfusion in selected rabbits using this technique. Thirty min after infusion the animals were sacrificed, and multiple specimens of liver, tumor, and heart were taken for liquid scintillation counting and high-performance liquid chromatography. The 14C label remained associated with Adriamycin and metabolites. After systemic infusion 11.5 nmol/g of Adriamycin were found in tumor, and 32.4 nmol/g were found in liver. Infusion of Adriamycin through the hepatic artery produced drug levels of 34.3 nmol/g of tumor and 48.4 nmol/g of liver, while infusion through the portal vein produced drug levels of 6.5 nmol/g of tumor and 54.4 nmol/g of liver. The drug concentration in tumor was significantly higher after hepatic artery infusion compared with systemic (P less than 0.05) or portal vein (P less than 0.01) infusion. The tumor/liver ratio of [14C]Adriamycin tissue levels after hepatic artery infusion was greater than that measured after systemic vein treatment (no overlap of the 90% confidence intervals). Systemic infusion of Adriamycin produced a higher level of Adriamycin in the heart (13.6 nmol/g) than did hepatic artery (10.9 nmol/g) or portal vein (8.9 nmol/g) infusion. Hepatic artery infusion achieved the highest tumor Adriamycin level compared with systemic vein and portal vein infusion. The results suggest that these tumor implants are supplied primarily by the hepatic artery, that clearance of Adriamycin is efficient after regional infusion, and that systemic toxicity may be reduced using intraarterial infusion of Adriamycin for hepatic tumors.

Ridge JA; Collin C; Bading JR; Hancock C; Conti PS; Daly JM; Raaf JH

1988-08-01

297

Infusion pharmacokinetics of Lipocurc™ (liposomal curcumin) and its metabolite tetrahydrocurcumin in Beagle dogs.  

UK PubMed Central (United Kingdom)

Curcumin's instability and its metabolite, tetrahydrocurcumin (THC) pose a major issue for the establishment of dependable pharmacokinetics and excretion profiles. Additional pharmacokinetic variances are associated with durations of intravenous infusions. We found that stabilizing curcumin with phosphoric acid allows accurate quantitative determinations of curcuminoids in the plasma and bile, by preventing degradation during the analytical processes. Two male and two females dogs were infused with Lipocurc™ 10 mg/kg over two hours, and another four dogs (two males and two females) were infused with Lipocurc™ 10 mg/kg over eight hours. Plasma levels of curcumin and THC were determined during the infusions and at necropsy. THC levels were 6.3-9.6-fold higher than curcumin during both infusion rates, suggesting a combination of a high-rate of enzymatic curcumin metabolism and a comparatively slower rate of blood THC clearance. When levels of curcumin and THC were compared during infusion durations, the two-hour infusion levels were significantly higher than the eight-hour infusion. The plasma half-lives of both compounds following the two-hour infusion ranged from 0.4-0.7 hours, and was a consequence of both hepatic and renal clearance However, at higher plasma concentrations renal excretion predominated, particularly with THC. Enhanced clearance rates were noted during eight-hour infusions, which prevented achieving a steady state. These observations suggest that for leukemias and lymphomas, the two-hour infusion may be advantageous based upon higher concentration profiles, and unstimulated clearance rates, however data on curcumin penetration into circulating hematopoietic cancer cells and efficacy data are required in order to confirm these suggestions.

Helson L; Bolger G; Majeed M; Vcelar B; Pucaj K; Matabudul D

2012-10-01

298

Comparative study between target-controlled-infusion and continuous-infusion anesthesia in dogs treated with methotrimeprazine and treated with propofol and remifentanil.  

UK PubMed Central (United Kingdom)

PURPOSE: To compare two propofol infusion techniques in bitches subjected to ovary histerectomy by estimating the efficiency of the propofol target-dose, evaluating the cardiorespiratory and hemogasimetric attributes, and the bispectral scale index (BIS) as well as the recovery period characteristics. METHODS: Twenty anesthetized bitches were divided into two groups of 10 each (G1, G2). Animals of G1 were pre-treated with methotrimeprazine and anesthetized with target-controlled propofol infusion by means of a Harvard infusion pump combined to remifentanil through a syringe pump. RESULTS: Bradycardia and light hypotension, hemogasimetric and respiratory stability besides a good myorelaxation, more evident during continuous infusion and good hypnosis. CONCLUSIONS: Dosis used in both techniques, after methotrimeprazine pre-treatment and combined to the opioid, were efficient for the surgery. The target-controlled anesthesia required a smaller anesthetic consumption (propofol) with faster recovery periods.

Hatschbach E; Silva Fdo C; Beier SL; Lima AF; Massone F

2008-01-01

299

Cesarean Section Birth  

Medline Plus

Full Text Available ... c-section delivery without labor, there's an increased risk for the baby to need some extra help. ... with each successive c-section, there's an increased risk of there being scar tissue, which may increase ...

300

System and method for blockage detection for medication infusion  

UK PubMed Central (United Kingdom)

A medication infusion system may include a controller and a reservoir module including a reservoir containing medication to be delivered to an internal wound site via the controller. The controller may have a peristaltic pump driven by a motor to urge medication to flow toward the internal wound site, through a conduit. A blockage sensor disables the motor and provides an alarm if the tube is blocked. The blockage sensor detects distention of a preferentially distendable portion of the tube, which may be routed about a constraining member. When blockage occurs, the tube distends preferentially along a direction generally parallel to the radius about which the tube bends.; The blockage sensor may include a variety of switching elements, such as a pushbutton switch, a metal ring encircling the tube to make contact between conductors, and/or a metal bridge bendable to make contact between conductors.

YAP MARC; CAHILL SEAN B; MASON JEFFERY T; PADERI ELIZABETH A; HOURMAND BYRON

 
 
 
 
301

SHOCK CAUSED BY CONTINUOUS INFUSION OF METARAMINOL BITARTRATE (ARAMINE).  

UK PubMed Central (United Kingdom)

Increasing doses of metaraminol bitartrate (Aramine) in a continuous intravenous infusion were used to support the blood pressure in four patients. Under such treatment a state of shock developed, characterized by intense peripheral vasoconstriction, hypotension and anuria. In spite of an adequate fluid intake all patients showed severe hemoconcentration, and a critically low plasma volume could be demonstrated in two. While metaraminol (Aramine) was ineffective, noradrenaline still caused a moderate blood pressure response. Treatment with plasma expanders (Intradex) and small doses of noradrenaline (Levophed) resulted in transient improvement in one patient and complete recovery from shock in three. The peripheral vasoconstriction persisted up to 12 hours and renal function improved on the second day after the withdrawal of metaraminol. The etiology of this shock syndrome is believed to be similar to that of experimental shock produced with adrenaline and noradrenaline.

SPOEREL WE; SELENY FL; WILLIAMSON RD

1964-02-01

302

Intra-arterial infusion of prostaglandin EI in Buerger's disease  

International Nuclear Information System (INIS)

[en] In Buerger's disease, arterial occlusion is so peripheral that reopening procedure such as reconstructive vascular surgery, percutaneous transluminal angioplasty and local fibrinolysis are not feasible, and major amputation is the only alternative. Prostaglandin E1, a potent vasodilator and inhibitor of platelet aggregation, has been used to treat the patients with severe arterial occlusive disease. In three cases of Buerger's disease, who are manifested by resting pain, non-healing ischemic ulcer, or impending gangrene and who were not candidates for direct arterial reconstructive procedure, we infused Prostaglandin El intraarterially at a fixed dosage to evaluate its effectiveness. We report our experience with the use of this drug in relieving the ischemic symptoms, healing the intractable ulcer, or avoiding the major amputation

1990-01-01

303

Medical infusion system with pulse width modulation and safety circuit  

UK PubMed Central (United Kingdom)

Medical infusion system (1,11,21,31) comprising a control signal generator (2,12), a safety circuit (3,13) consisting of a high-pass circuit, a switching device (4,14) and a pump DC motor (5), wherein the pump motor (5) and the switching device (4,14) are connected in series and constitute a power supply circuit to be connected to a power supply. The control signal generator (2,12), configured to generate an AC control signal e.g. PWM, is connected to the input (3a,13a) of the safety circuit (3,13). The output (3b,13b) of the safety circuit (3,13) is connected to a control input (3a,13a) of the switching device (4,14). The pump DC motor (5) will not operate, if there is no AC signal applied to the input of the safety circuit (3,13).

FEHR JEAN-NOEL; VON BUEREN THOMAS; TROLLER STEFAN; MATTMUELLER MARC

304

Anaphylactic shock and cardiac arrest caused by thiamine infusion  

DEFF Research Database (Denmark)

Parenteral thiamine has a very high safety profile. The most common adverse effect is local irritation; however, anaphylactic or anaphylactoid reactions may occur, mostly related to intravenous administration. We describe a 44-year-old man, a chronic alcoholic, who was admitted with alcohol intoxication and developed cardiac arrest due to anaphylactic shock following intravenous thiamine infusion. The patient was successfully resuscitated after 15 min and repeated epinephrine administrations. He was discharged in good health after 14 days. This case report emphasises both the importance of recognising the symptoms of anaphylaxis and the fact that facilities for treating anaphylaxis and cardiopulmonary resuscitation should be available when thiamine or for that matter, any drug is given in-hospital.

Juel, Jacob; Pareek, Manan

2013-01-01

305

Infusing a diversity perspective into human development courses.  

UK PubMed Central (United Kingdom)

Students of human development must be well versed in issues of diversity if they are to appreciate the importance of developmental contextualism, and comprehend policy and professional issues related to poverty and ethnicity. One difficulty in addressing diversity issues in the minimal empirical foundation, a fact that was confirmed in Study 1 by content analyses of research on child and adolescent development. More problematic, sampling patterns reinforce a deficit perspective on low-income minority adolescents. Study 2 describes evaluation findings from a curriculum enhancement project, in which multicultural content was infused into a sequence of human development courses. Significant changes in attitudes toward poverty and racial minorities were observed in targeted courses, relative to comparison groups. Evidence is presented that this curriculum project decreased ethnocentrism and increased critical thinking skills and awareness of poverty as a developmental risk factor. Implications for pedagogy, research, and the culture of higher education are discussed.

MacPhee D; Kreutzer JC; Fritz JJ

1994-04-01

306

Infusing a diversity perspective into human development courses.  

Science.gov (United States)

Students of human development must be well versed in issues of diversity if they are to appreciate the importance of developmental contextualism, and comprehend policy and professional issues related to poverty and ethnicity. One difficulty in addressing diversity issues in the minimal empirical foundation, a fact that was confirmed in Study 1 by content analyses of research on child and adolescent development. More problematic, sampling patterns reinforce a deficit perspective on low-income minority adolescents. Study 2 describes evaluation findings from a curriculum enhancement project, in which multicultural content was infused into a sequence of human development courses. Significant changes in attitudes toward poverty and racial minorities were observed in targeted courses, relative to comparison groups. Evidence is presented that this curriculum project decreased ethnocentrism and increased critical thinking skills and awareness of poverty as a developmental risk factor. Implications for pedagogy, research, and the culture of higher education are discussed. PMID:8013249

MacPhee, D; Kreutzer, J C; Fritz, J J

1994-04-01

307

Ist die subkutane Infusion eine praktische Alternative in der Geriatrie?  

Directory of Open Access Journals (Sweden)

Full Text Available In der Geriatrie hat das Thema der Flüssigkeitssubstitution einen besonderen Stellenwert - so verwundert es nicht, daß hauptsächlich Geriater die subkutane Infusion als Methode der Flüssigkeitszufuhr für ihre Patienten wiederentdeckten. Sie gilt heute als einfach, komplikationsarm, sicher und vor allem als für den Patienten schonend. Sie hat viele Vorteile und nur wenige Nachteile. Ihre Domäne ist die Vorbeugung von Dehydratation in Situationen, die dafür ein Risiko darstellen, sowie die Therapie von leichter bis mäßiger Dehydratation. Die bis vor wenigen Jahren, als neue Publikationen zu diesem Thema erschienen, archaisch anmutende Methode wurde jahrzehntelang kaum mehr angewandt und wenn, dann höchstens mit einem schlechten Gewissen und der Verzweiflung, keinen intravenösen Zugang gefunden zu haben. Sie schnitt auch hinsichtlich Sicherheit und Komplikationsrate im Vergleich zu den damals neu entwickelten Technologien und Materialien für den intravenösen Zugang schlechter ab. In einer kurzen Literaturübersicht wird über die Indikationen, Kontraindikationen und die Technik dieser wiederentdeckten Methode der Flüssigkeitssubstitution berichtet.

Frühwald T

2001-01-01

308

A nursing process model: quantifying infusion therapy resource consumption.  

UK PubMed Central (United Kingdom)

Comprehensive measurement of the effort associated with a procedure, treatment, or project involves a myriad of planned observations and analyses. When accurately synthesized, these measurements show the amount of resources or the level of effort required for the intervention. In an era of unprecedented healthcare cost scrutiny, it is imperative for clinicians to understand and apply these components and methods to program development, budget management, staffing, and cost-to-outcome analysis. Through a series of on-site observations and interviews at in-office infusion centers providing a nonchemotherapeutic biologic therapy, specifically infliximab (Remicade), the investigators were able to isolate and assign value to the multiple factors that contribute to the cost of this procedure. The investigators also were able to establish a process model for clinicians who are inevitably involved in the "business" of healthcare.

Pierce CA; Baker JJ

2004-07-01

309

Infusing gerontology into grades 7-12 social studies curricula.  

UK PubMed Central (United Kingdom)

PURPOSE: This paper describes a model process to increase the exposure of middle and high school students to information on aging so they better understand the implications of an aging population and the stereotypes of older adults. DESIGN AND METHODS: A college Gerontology Institute, a social studies teacher education faculty member, and middle/high school social studies teachers collaborated on a program to develop and implement lesson plans that incorporate information on aging into existing courses. Institute staff provided expertise on gerontology and student teachers assisted in writing lesson plan objectives. RESULTS: Teachers developed about a dozen lessons covering from one class to two weeks in subjects such as global history, participation in government, Western civilizations, economics, and government. This experience suggests a number of issues that should be addressed when developing a gerontology infusion initiative with school teachers. IMPLICATIONS: Information on aging can be successfully incorporated into existing school curricula within the constraints of mandated learning objectives.

Krout JA; Wasyliw Z

2002-06-01

310

The environmental impact of health care: implications for infusion nursing.  

UK PubMed Central (United Kingdom)

Health care provision is a dangerous business. Health professionals recognize the potential for miscommunication, medication errors, and other possible threats to patient safety. Less evident are the hazards to the environment inherent in the everyday practice of patient care. This article addresses 3 areas of practice in which infusion nurses can make a positive impact on the environment: preferable intravenous (IV) supply purchasing, proper management of electronic equipment (including purchasing, servicing, and disposal), and appropriate medication use and disposal practices. The article aims to inform IV nurses of the alarming environmental effects that the health care industry has on the environment and to suggest a clear, direct course of action to improve our environmental impact.

Lipkin NC

2012-05-01

311

Implementation of intraosseous infusion technique by aeromedical transport programs.  

UK PubMed Central (United Kingdom)

Aeromedical transport program implementation of intraosseous infusion (IOI) was ascertained by telephone survey. One hundred thirty-three programs were polled: 69.2% had never utilized IOI nor were considering its use; 13.5% had previously utilized IOI; 15.8% had not yet implemented IOI but had been in-serviced on the technique; and 1.5% were considering implementation. Of 39 programs previously in-serviced or presently utilizing the procedure, seven restricted IOI insertion to physicians while 32 permitted placement by nurses or paramedics. Half of the programs would pursue IOI immediately after a 5-minute trial of peripheral line placement in preference to cutdown or central venous line attempts. About 50 IOI were performed by aeromedical transport personnel in 1986. Rate of successful insertion was approximately 80%. Complications were few and minor. This survey demonstrates that the simple, safe technique of IOI is being grossly under-utilized and warrants further consideration.

Zimmerman JJ; Coyne M; Logsdon M

1989-05-01

312

A flexible infusion micro-cannula for subretinal surgery.  

Science.gov (United States)

Injection of fluids or drugs into the subretinal space is often necessary during subretinal surgery. The authors have developed a flexible micro-cannula for subretinal surgery that can be used for submacular injection of drugs or for atraumatic hydrodissection of the retina. The novel features of the soft tip include reduced diameter (200 microns), increased length, and material selection for resistance to tip buckling. The authors have used this cannula following pars plana vitrectomy for 14 patients with subfoveal choroidal neovascularization secondary to age-related macular degeneration (13 patients) and angioid streaks (1 patient). The cannula creates a relatively atraumatic retinotomy and allows an efficient, controlled injection of subretinal fluid. This micro-cannula seems to be a valuable tool for the subretinal infusion of fluids or drugs. PMID:9304644

Loewenstein, A; Rader, R S; Shelley, T H; de Juan, E

1997-09-01

313

Infusion set characteristics such as antireflux valve and dead-space volume affect drug delivery: an experimental study designed to enhance infusion sets.  

UK PubMed Central (United Kingdom)

BACKGROUND: The ability of an infusion set to deliver a specific amount of drug to the patient can be directly related to the presence of an antireflux valve and dead-space volume. In this study we quantified separately the impact of these 2 components on drug delivery. METHODS: Various infusion sets were assessed differing in length, in dead-space volume, and with or without an antireflux valve. Noradrenaline was infused with a syringe pump simultaneously with a carrier flow. Effluent drug concentration was measured using ultraviolet spectrophotometry. Flow change efficiency (FCE) was calculated from the ratio of the area under the experimental mass flow rate curve to the area under the theoretical instantaneous mass flow rate curve. RESULTS: The FCE for infusion sets with or without antireflux valves were significantly different 10 to 15 minutes after the start of an infusion at flow rates of 7 mL/h for noradrenaline and 35 mL/h to 70 mL/h for the carrier fluid. They were not different with a carrier flow of 115 mL/h. DISCUSSION: These findings suggest that antireflux valves have a significant impact on FCE when the ratio of drug flow rate to carrier fluid flow rate is high. Infusion sets with very low dead-space volume connectors yield better FCE. There is a nonlinear relationship between dead-space volume and FCE 5 to 10 minutes after the onset of drug infusion. CONCLUSION: Care providers must consider dead-space volume and the presence of an antireflux valve when choosing their infusion sets.

Lannoy D; Décaudin B; Dewulf S; Simon N; Secq A; Barthélémy C; Debaene B; Odou P

2010-12-01

314

Continuous infusion of antibiotics in critically ill patients.  

UK PubMed Central (United Kingdom)

Antibiotics are the most commonly used drugs in intensive care unit patients and their supply should be based on pharmacokinetic/pharmacodynamic rules. The changes that occur in septic patients who are critically ill may be responsible for subtherapeutic antibiotic concentrations leading to poorer clinical outcomes. Evolving in time the disturbed pathophysiology in severe sepsis (high cardiac output, glomerular hyperfiltration) and therapeutic interventions (e.g. haemodynamically active drugs, mechanical ventilation, renal replacement therapy) alters antibiotic pharmacokinetics mainly through an increase in the volume of distribution and altered drug clearance. The lack of new and efficacious drugs and increased bacterial resistance are current problems of contemporary antibiotic therapy. Although intermittent administration is a standard clinical practice, alternative methods of antibiotic administration are sought, which may potentialise effects and reduce toxicity as well as contribute to inhibition of bacterial resistance. A wide range of studies prove that the application of continuous infusion of time-dependent antibiotics (beta-lactams, glycopeptides) is more rational than standard intermittent administration. However, there are also studies which do not confirm the advantage of one method over the other. In spite of controversy the continuous administration of this group of antibiotics is common practice, because the results of both studies point to the higher efficacy of this method in critically ill patients. Authors reviewed the literature to determine whether any clinical benefits exist for administration of time-dependent antibiotics by continuous infusion. Definite specification of the clinical advantage of administration this way over standard dosage requires a large-scale multi-centre randomised controlled trial.

Smuszkiewicz P; Sza?ek E; Tomczak H; Grze?kowiak E

2013-02-01

315

Hydrophobic liquid-infused porous polymer surfaces for antibacterial applications.  

Science.gov (United States)

Biofilms represent a fundamental problem in environmental biology, water technology, food hygiene as well as in medical and technical systems. Recently introduced slippery liquid-infused porous surface (SLIPS) showed great promise for preventing biofilm formation owing to the low surface energy of such surface in combination with its self-cleaning properties. In this study we demonstrated a novel hydrophobic liquid-infused porous poly(butyl methacrylate-co-ethylene dimethacrylate) surface (slippery BMA-EDMA) with bacteria-resistance in BM2 mineral medium and long-term stability in aqueous environments. We showed that the slippery BMA-EDMA surface prevents biofilm formation of different strains of opportunistic pathogen Pseudomonas aeruginosa for at least up to 7 days in low nutrient medium. Only ?1.8% of the slippery surface was covered by the environmental P. aeruginosa PA49 strain under investigation. In uncoated glass controls the coverage of surfaces reached ?55% under the same conditions. However, in high nutrient medium, more relevant to physiological conditions, the biofilm formation on the slippery surface turned out to be highly dependent on the bacterial strain. Although the slippery surface could prevent biofilm formation of most of the P. aeruginosa strains tested (?1% surface coverage), the multiresistant P. aeruginosa strain isolated from wastewater was able to cover up to 12% of the surface during 7 days of incubation. RAPD-PCR analysis of the used P. aeruginosa strains demonstrated their high genome variability, which might be responsible for their difference in biofilm formation on the slippery BMA-EDMA surface. The results show that although the slippery BMA-EDMA surface has a great potential against biofilm formation, the generality of its bacteria resistant properties is still to be improved. PMID:23777668

Li, Junsheng; Kleintschek, Tanja; Rieder, Annika; Cheng, Yin; Baumbach, Tilo; Obst, Ursula; Schwartz, Thomas; Levkin, Pavel A

2013-07-05

316

Intracoronary stem cell infusion in heart transplant candidates.  

Science.gov (United States)

The stem cell transplantation is emerging as a potential therapeutic modality for patients with heart failure. It has been demonstrated that intracoronary stem cell transplantation had beneficial effects on left ventricular perfusion and contractile functions. We hypothesized that patients with end-stage ischemic cardiomyopathy, who are candidates for heart transplantation, could also benefit from autologous intracoronary stem cell transplantation. We performed a prospective, open-labeled study in 10 patients with end-stage ischemic cardiomyopathy, who were on the waiting list for heart transplantation. Each patient received bone marrow-derived mononuclear cell infusion via balloon catheter in the target vessel, which had been revascularized by percutaneous intervention and was patent before the procedure. Clinical and laboratory evaluations, a treadmill exercise test, echocardiography, and single photon emission tomography (SPECT) were performed to the patients at baseline and 6 months after stem cell infusion. At 6-month follow-up of the eight patients who were able to complete the study, we revealed a significant increase in ejection fraction (from 30.0 +/- 6.6% to 36.2 +/- 7.3%; p = 0.001) in echocardiographic evaluation. SPECT evaluation also displayed a reduction in infarct area (50.4 +/- 16.1% to 44.1 +/- 12.5%; p = 0.003). Both myocardial oxygen consumption (p = 0.001) and metabolic equivalents (p = 0.001) were significantly increased at 6-month follow-up. These results demonstrate that intracoronary stem cell transplantation ameliorates heart failure symptoms and improves left ventricular function and perfusion. Therefore intracoronary stem cell transplantation may be used as an alternative treatment option for heart transplant candidates. PMID:17917404

Yelda, Tayyareci; Berrin, Umman; Murat, Sezer; Aytac, Oncul; Sevgi, Besisik; Yasemin, Sanli; Ay?e, Mudun; Deniz, Sargin; Yilmaz, Nisanci

2007-10-01

317

Intracoronary stem cell infusion in heart transplant candidates  

International Nuclear Information System (INIS)

The stem cell transplantation is emerging as a potential therapeutic modality for patients with heart failure. It has been demonstrated that intracoronary stem cell transplantation had beneficial effects on left ventricular perfusion and contractile functions. We hypothesized that patients with end-stage ischemic cardiomyopathy, who are candidates for heart transplantation, could also benefit from autologous intracoronary stem cell transplantation. We performed a prospective, open-labeled study in 10 patients with end-stage ischemic cardiomyopathy, who were on the waiting list for heart transplantation. Each patient received bone marrow-derived mononuclear cell infusion via balloon catheter in the target vessel, which had been revascularized by percutaneous intervention and was patent before the procedure. Clinical and laboratory evaluations, a treadmill exercise test, echocardiography, and single photon emission tomography (SPECT) were performed to the patients at baseline and 6 months after stem cell infusion. At 6-month follow-up of the eight patients who were able to complete the study, we revealed a significant increase in ejection fraction (from 30.0±6.6% to 36.2±7.3%; p=0.001) in echocardiographic evaluation. SPECT evaluation also displayed a reduction in infarct area (50.4±16.1% to 44.1±12.5%; p=0.003). Both myocardial oxygen consumption (p=0.001) and metabolic equivalents (p=0.001) were significantly increased at 6-month follow-up. These results demonstrate that intracoronary stem cell transplantation ameliorates heart failure symptoms and improves left ventricular function and perfusion. Therefore intracoronary stem cell transplantation may be used as an alternative treatment option for heart transplant candidates. (author)

2007-01-01

318

Combination high-dose etoposide and vincristine infusion.  

Science.gov (United States)

Following the identification of a synergistic antitumor effect in a murine model, the combination of etoposide and vincristine has been explored in the clinic. Etoposide was given at 4 dose levels (250, 500, 750 or 1,000 mg/m2) with each dose given in 3 equal fractions daily for 3 days. The dose of vincristine was fixed (two 0.75 mg infusions over 22 hours each between doses of etoposide). A total of 26 patients were entered into study and 7, 11, 10 and 5 patients were treated at the 250, 500, 750, and 1,000 mg/m2 dose levels, respectively. Myelosuppression was the principle side effect and Grade 4 WBC toxicity (less than 1,000/mm3) developed in 14%, 27%, 40% and 40%, respectively, of the patients treated at each of these respective dose levels. Life-threatening infections occurred in 0%, 9%, 30% and 60% of the patients at these levels, respectively. Reversal of marrow toxicity was rapid with repeat courses given at 3-week intervals. Non-hematologic toxicity, including neurotoxicity, nausea, vomiting, and mucositis was generally mild when present. Objective responses were observed in 1 patient each with refractory Hodgkin's disease and immunoblastic lymphoma. Prolonged periods of stable disease occurred in 2 patients with adenocarcinoma of the lung and one patient with Hodgkin's disease. The starting dose of etoposide recommended for further trials of this agent in combination with infusion of vincristine is 500 mg/m2 given in fractionated doses; dose escalation should be possible in many patients. PMID:2380018

Jackson, D V; Cruz, J M; White, D R; Muss, H B; Chauvenet, A R

1990-01-01

319

Combination high-dose etoposide and vincristine infusion.  

UK PubMed Central (United Kingdom)

Following the identification of a synergistic antitumor effect in a murine model, the combination of etoposide and vincristine has been explored in the clinic. Etoposide was given at 4 dose levels (250, 500, 750 or 1,000 mg/m2) with each dose given in 3 equal fractions daily for 3 days. The dose of vincristine was fixed (two 0.75 mg infusions over 22 hours each between doses of etoposide). A total of 26 patients were entered into study and 7, 11, 10 and 5 patients were treated at the 250, 500, 750, and 1,000 mg/m2 dose levels, respectively. Myelosuppression was the principle side effect and Grade 4 WBC toxicity (less than 1,000/mm3) developed in 14%, 27%, 40% and 40%, respectively, of the patients treated at each of these respective dose levels. Life-threatening infections occurred in 0%, 9%, 30% and 60% of the patients at these levels, respectively. Reversal of marrow toxicity was rapid with repeat courses given at 3-week intervals. Non-hematologic toxicity, including neurotoxicity, nausea, vomiting, and mucositis was generally mild when present. Objective responses were observed in 1 patient each with refractory Hodgkin's disease and immunoblastic lymphoma. Prolonged periods of stable disease occurred in 2 patients with adenocarcinoma of the lung and one patient with Hodgkin's disease. The starting dose of etoposide recommended for further trials of this agent in combination with infusion of vincristine is 500 mg/m2 given in fractionated doses; dose escalation should be possible in many patients.

Jackson DV Jr; Cruz JM; White DR; Muss HB; Chauvenet AR

1990-01-01

320

Brain SPECT by intraarterial infusion of 99mTc-HMPAO for assessing the cerebral distribution of carotid artery infusions in patient with brain tumor  

International Nuclear Information System (INIS)

In order to assess the cerebral distribution of intracarotid chemotherapy, 17 postoperative patients with brain tumor underwent brain SPECT obtrained by intraarterial infusion of 18.5 MBq of 99mTc-d,l,-hexamethylpropyleneamine oxime (99mTc-HMPAO). Injection methods were continuous (5.0 ml/min) or pulsatile infusion with supra- or infraophthalmic catheterization. The findings obtained by brain SPECT were frequently different from those of angiography and/or DSA. In supraophthalmic catheterization with continuous infusion, only 2 of 10 studies (20%) had homogeneous distribution and 5 of them (50%) had maldistribution of 99mTc-HMPAO which appears in association with laminar flow effect. The remaining 3 studies showed localized distribution (two: tumor localization, one: healthy brain localization). On the other hand, all of 5 studies with pulsatile infusion had homogeneous distribution of 99mTc-HMPAO. In infraophthalmic catheterization, all but one of 5 studies had homogeneous distribution with continuous infusion. These results suggest that pulsatile infusion may be effective in eliminating maldistribution of 99mTc-HMPAO in supraophthalmic catheterization. In conclusion, we are convinced that 99mTc-HMPAO is a useful intraarterial agent for assessing cerebral distribution of intracarotid chemotherpay. (author).

1993-01-01

 
 
 
 
321

Localized bullous eruptions away from infusion site due to intravenous acyclovir administration in a child.  

UK PubMed Central (United Kingdom)

Acyclovir is an antiviral agent against herpes virus. Its local adverse effects are common and typically consist of inflammation or phlebitis at the site of intravenous infusion. Here we present a child with bullous eruptions away from infusion site due to acyclovir administration. It is exceptionally rare with only one adult case has been reported to date.

Gurkan A; Erkek N; Senel S

2012-01-01

322

Effect of corticosteroids on phlebitis induced by intravenous infusion of antineoplastic agents in rabbits  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Purpose: Phlebitis caused by intravenous infusion of antineoplastic agents is one of the critical problems when anticancer therapy is prolonged. We have already reported that both rapid infusion and dilution of the injection solution were effective methods for reducing phlebitis caused by vinorelbin...

Kohno, Emiko; Murase, Saori; Matsuyama, Kenji; Okamura, Noboru

323

Effects of glucose infusion on hormone secretion and hepatic glucose production during heavy exercise.  

UK PubMed Central (United Kingdom)

Blood-borne metabolic feedback vs. neural feedforward regulation of glucose homeostasis during exercise was investigated by infusion glucose and [3H]glucose for glucose appearance determination intravenously in rats running for 20 min at 28 m/min [approximately 85% of maximal O2 consumption (VO2max)]. Infused glucose corresponded to the exercise-induced increase in hepatic glucose production (HGP) found in saline-infused rats. Saline- and glucose-infused resting rats were also studied. Arterial blood was sampled for analyses of hormones and metabolites. Plasma epinephrine, norepinephrine, and insulin were always similar and HGP was initially similar in the two exercising groups, although glucose infusion resulted in higher plasma glucose compared with control (P < 0.05). Late during exercise, high plasma glucose (11.3 +/- 0.4 vs. 9.6 +/- 0.3 mM) and low glucagon (16 +/- 2 vs. 27 +/- 3 pM) in glucose- vs. saline-infused rats caused an inhibition of HGP in glucose-infused rats, although never below preexercise levels. In resting rats, glucose infusion resulted in elevated plasma glucose and insulin and, in turn, inhibition of HGP but had no effect on catecholamines, corticosterone, or glucagon. The findings indicate that during heavy exercise, glucose homeostasis is regulated primarily by neural feedforward mechanisms and that blood-borne metabolic feedback mechanisms play a regulatory role if metabolic error signals are pronounced.

Wiersma MM; Vissing J; Steffens AB; Galbo H

1993-12-01

324

Effect of intravenous iron-dextran (Imferon) infusion on antigen induced monarticular arthritis in rabbits.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The effect of intravenously infused iron-dextran (Imferon) on the progression of antigen induced monarticular arthritis in rabbits was studied. A rapid deposition of iron and apoferritin in the synovia of arthritis joints occurred after infusion of iron-dextran during either the acute or chronic pha...

Kind, C N; Blackham, A; Morris, C J

325

Intramammary Honey Infusion: A New Trend in the Management of Bovine Subclinical Mastitis  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The objective of this study was to determine the most suitable and effective regimen of intramammary honey infusion in bovine subclinical mastitis. A total of twenty five subclinical mastitic cows from two farms were divided into two groups; group a: 10 lactating cows were infused 10 mL fennel honey...

Nahed M. Wahba; Neveen A. EL Nisr; S.M. Sayed; M.R. Abd Ellah; M.M. Abd El-Hafeez; A.A. Aamer

326

Appearance and Characterization of Lipoprotein X during Continuous Intralipid Infusions in the Neonate  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The development of hyperphospholipidemia and hypercholesterolemia was studied in infants that required total parenteral nutrition and given a continuous infusion of Intralipid, (1-4 g/kg body wt per 24 h. Detailed studies were carried out on infusion periods lasting 1-10 d. After 24 h there was a ma...

Griffin, E.; Breckenridge, W. C.; Kuksis, A.; Bryan, M. H.; Angel, A.

327

Pharmacokinetics of progesterone after its administration to ovariectomized rhesus monkeys by injection, infusion, or nasal spraying.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The pharmacokinetics of progesterone (dose: 10 microgram per animal) were studied in blood and cerebrospinal fluid of adult ovariectomized rhesus monkeys after the administration of the steroid as an intravenous injection, intravenous infusion (duration of infusion: 10 min), or nasal spray. The bioa...

Anand Kumar, T C; David, G F; Sankaranarayanan, A; Puri, V; Sundram, K R

328

Metabolomics reveals increased isoleukotoxin diol (12,13-DHOME) in human plasma after acute Intralipid infusion.  

UK PubMed Central (United Kingdom)

Intralipid is a fat emulsion that is regularly infused into humans and animals. Despite its routine use, Intralipid infusion can cause serious adverse reactions, including immunosuppression. Intralipid is a complex mix of proteins, lipids, and other small molecules, and the effect of its infusion on the human plasma metabolome is unknown. We hypothesized that untargeted metabolomics of human plasma after an Intralipid infusion would reveal novel insights into its effects. We infused Intralipid and saline into 10 healthy men in a double-blind, placebo-controlled experiment and used GC/MS, LC/MS, and NMR to profile the small-molecule composition of their plasma before and after infusion. Multivariate statistical analysis of the 40 resulting plasma samples revealed that after Intralipid infusion, a less-well-characterized pathway of linoleic acid metabolism had resulted in the appearance of (9Z)-12,13-dihydroxyoctadec-9-enoic acid (12,13-DHOME, P < 10(-3)), a leukotoxin that has powerful physiological effects and is known to inhibit the neutrophil respiratory burst. Intralipid infusion caused increased plasma 12,13-DHOME. Given that 12,13-DHOME is known to directly affect neutrophil function, we conclude that untargeted metabolomics may have revealed a hitherto-unknown mechanism of intralipid-induced immunosuppression.

Edwards LM; Lawler NG; Nikolic SB; Peters JM; Horne J; Wilson R; Davies NW; Sharman JE

2012-09-01

329

Feedback modeling of non-esterified fatty acids in rats after nicotinic acid infusions  

Digital Repository Infrastructure Vision for European Research (DRIVER)

A feedback model was developed to describe the tolerance and oscillatory rebound seen in non-esterified fatty acid (NEFA) plasma concentrations following intravenous infusions of nicotinic acid (NiAc) to male Sprague-Dawley rats. NiAc was administered as an intravenous infusion over 30 min (0, 1, 5 ...

Ahlström, Christine; Peletier, Lambertus A.; Jansson-Löfmark, Rasmus; Gabrielsson, Johan

330

Aedes albopictus (Diptera: Culicidae) oviposition response to organic infusions from common flora of suburban Florida.  

UK PubMed Central (United Kingdom)

We evaluated the oviposition response of gravid Aedes albopictus (Skuse) to six organic infusions. Laboratory and field-placed oviposition cups baited with water oak (Quercus nigra L.), longleaf pine (Pinus palustris P. Mill), or St. Augustine grass (Stenotaphrum secundatum (Walt.) Kuntze), as well as binary infusion mixtures of each, were used. In addition, a triple-cage, dual port olfactometer was used to measure upwind response of gravid individuals to these infusions. We found that Ae. albopictus deposited more eggs in infusion-baited cups compared with water alone. Moreover, significantly more eggs were laid in the water oak and a water oak-pine mixture as compared with the St. Augustine grass infusion in laboratory bioassays. However, a negative upwind response was observed with longleaf pine infusion in the olfactometer. In field cages, significantly more eggs were deposited in infusion-baited cups as compared with water alone and a greater percentage of eggs were deposited in cups containing a water oak and the water oak-longleaf pine mixture as compared with cups containing single infusions or their mixtures.

Obenauer PJ; Allan SA; Kaufman PE

2010-12-01

331

Toxicity of Guanazole (NSC 1895) Administered by 48-Hour Intravenous Infusions in Dogs.  

Science.gov (United States)

Two dogs were administered 5.0 gm/kg Guanazole, Triazole 3,5-diamino-S (NSC 1895) by 48-hour i.v. infusion followed by an observation period of 183 days and a second infusion of 7.5 gm/kg. Clinical signs were minimal but liver damage was indicated by tran...

P. E. Palm E. P. Arnold P. C. Rachwall C. J. Kensler

1972-01-01

332

Evaluation of slow infusions of co-trimoxazole by using predictive pharmacokinetics.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Digital computer simulations of plasma concentration-time profiles of single intravenous infusions of trimethoprim (160 mg)/sulfamethoxazole (800 mg) based on data from other workers showed that increasing the infusion period from the hitherto generally recommended 1 to 1.5 h to 6 h did not signific...

Morgan, D J; Raymond, K

333

Dispensable medical infusion apparatus capable of automatically closing and alarming at end of dripping  

UK PubMed Central (United Kingdom)

The invention discloses a dispensable medical infusion apparatus capable of automatically closing and alarming at end of dripping. The infusion apparatus concretely comprises a temporary liquid medicine container (1), an infusion tube (2) and a liquid medicine flow rate regulator, and is characterized by being provided with a structure for automatically closing the infusion tube when the liquid medicine drips out: a floater (4) capable of reciprocally moving on a central axis basically parallel to the temporary liquid medicine container (1) and a structure capable of ensuring the floater (4) blocks an infusion passage when falling down and closes the infusion apparatus are arranged in the temporary liquid medicine container (1). The dispensable medical infusion apparatus capable of automatically closing and alarming when the liquid medicine drips out is simple and effective in structure, low in cost and convenient in use. Meanwhile, the invention provides a plurality of alarming designschemes which are selectable according to actual needs. The infusion apparatus is a break through of the prior part and has foreseeable great economic and social values.

BAIHE WANG

334

Continuous extrapleural infusion of ropivacaine 0.2% after cardiovascular surgery via the lateral thoracotomy approach  

Digital Repository Infrastructure Vision for European Research (DRIVER)

OBJECTIVE: The pharmacokinetics of ropivacaine 0.2% were evaluated during a 48-hour continuous extrapleural infusion with 2 different infusion rates in patients undergoing cardiovascular surgery. The hypotheses that no toxic plasma concentrations of ropivacaine would be reached and that proportional...

Maurer, K; Blumenthal, S; Rentsch, K M; Schmid, E R

335

[The treatment of Paget's disease of bone with second-generation bisphosphonates via intravenous infusion  

UK PubMed Central (United Kingdom)

We compared the biochemical effects and safety of pamidronate (30 mg a day for 3 consecutive days) versus clodronate (300 mg a day for 3 consecutive days) via intravenous infusion in 14 patients with Paget's disease of bone (PDB). Both drugs induced a decrease in serum alkaline phosphatase levels as well as the elimination of hydroxyproline from urine, an effect most marked in the group treated with pamidronate. The response was maintained for 6 months after the infusion in the majority of the patients. No relevant side effects were found, except post-infusion febricula and in one patient, self-limiting thrombopenia 6 months after the infusion. We conclude that the intravenous infusion of either of the two drugs may constitute a safe and effective alternative for treatment of PDB with marked biochemical activity or resistant to conventional therapy.

Arboleya L; Sánchez J; Iglesias G; Arranz JL

1993-12-01

336

Long-term BPA infusions. Evaluation in the rat brain tumor and rat spinal cord models  

Energy Technology Data Exchange (ETDEWEB)

In the BPA-based dose escalation clinical trial, the observations of tumor recurrence in areas of extremely high calculated tumor doses suggest that the BPA distribution is non-uniform. Longer (6-hour) i.v. infusions of BPA are evaluated in the rat brain tumor and spinal cord models to address the questions of whether long-term infusions are more effective against the tumor and whether long-term infusions are detrimental in the central nervous system. In the rat spinal cord, the 50% effective doses (ED{sub 50}) for myeloparesis were not significantly different after a single i.p. injection of BPA-fructose or a 6 hour i.v. infusion. In the rat 9L gliosarcoma brain tumor model, BNCT following 2-hr or 6-hr infusions of BPA-F produced similar levels of long term survival. (author)

Coderre, J.A.; Micca, P.L.; Nawrocky, M.M.; Joel, D.D. [Brookhaven National Laboratory, Medical Department, Upton, NY (United States); Morris, G.M. [University of Oxford, Research Institute, Oxford (United Kingdom)

2000-10-01

337

Comparison of surface modifications of poly(ether urethanes) by chemical infusion and graft polymerization  

Energy Technology Data Exchange (ETDEWEB)

Our approach to surface modification uses the chemical infusion process to introduce materials into the outermost layer of the polymeric material, thereby altering the surface without changing the bulk properties of the polymer. The infused materials may slowly diffuse out of the infusion layer if they are volatile or highly mobile. However, if polymeric infusant materials are employed, they may become chain entangled with the host polymer and result in a permanently modified surface. A second approach utilizes photo-initiated graft polymerization of poly(ether urethanes) with an appropriate monomer. We have explored both of these methods by examining the infusion of polyvinylpyrrolidone (PVP) and poly(ethylene glycol) (PEG) into commercially available poly(ether urethanes) and the graft polymerization of N-vinyl pyrrolidone onto poly(ether urethanes). Results are presented here. 7 refs., 1 tab.

Wrobleski, D.A.; Cash, D.L.; Hermes, R.E.

1988-01-01

338

Attribute based selection of thermoplastic resin for vacuum infusion process : A decision making methodology  

DEFF Research Database (Denmark)

The composite industry looks toward a new material system (resins) based on thermoplastic polymers for the vacuum infusion process, similar to the infusion process using thermosetting polymers. A large number of thermoplastics are available in the market with a variety of properties suitable for different engineering applications, and few of those are available in a not yet polymerised form suitable for resin infusion. The proper selection of a new resin system among these thermoplastic polymers is a concern for manufactures in the current scenario and a special mathematical tool would be beneficial. In this paper, the authors introduce a new decision making tool for resin selection based on significant attributes. This article provides a broad overview of suitable thermoplastic material systems for vacuum infusion process available in today’s market. An illustrative example—resin selection for vacuum infused of a wind turbine blade—is shown to demonstrate the intricacies involved in the proposed methodology for resin selection.

Prabhakaran, R.T. Durai; Lystrup, Aage

2011-01-01

339

Mineral Analysis the Infusion of Black Tea Samples by Atomic Absorption Spectrometry  

Directory of Open Access Journals (Sweden)

Full Text Available Tea infusion is one of the most popular drinks around the world. Since tea infusion is known to contain several essential nutrients, it is considered a healthy beverage. In this study eight different Iranian brands of tea infusion and eleven brands imported tea infusion samples from another country for Cu, Zn, Mn and Al were determined by flame atomic absorption spectrometry after wet digestion. The results of analysis showed that the extraction rates of minerals from dry black tea to infusion tea were for Mn (19.35%), Cu (22.75%), Zn (54.43%) and Al (61.48%). The results obtained from this analysis have shown good accuracy.

Lahiji N.; Tadayon F.; Tamiji F.; Lahiji A. H.

2013-01-01

340

Labetalol infusion for refractory hypertension causing severe hypotension and bradycardia: an issue of patient safety  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Incremental doses of intravenous labetalol are safe and effective and, at times, such therapy may need to be augmented by a continuous infusion of labetalol to control severe hypertension. Continuous infusions of labetalol may exceed the recommended maximum daily dose of 300 mg on occasion. We report a case in which hypertension occurring after an abdominal aortic aneurysm repair, initially responsive to intermittent intravenous beta-blockade, became resistant to this therapy leading to the choice of an intravenous labetalol infusion as the therapeutic option. The labetalol infusion resulted in a profound cardiovascular compromise in this postoperative critically ill patient. While infusions of labetalol have successfully been used, prolonged administration in the intensive care unit requires vigilance and the establishment of a therapeutic rationale/policy for interventions, such as the ready availability of glucagon, ?-agonists, phosphodiesterase inhibitors, insulin, and vasopressin when severe cardiovascular depression occurs.

Fahed Samir; Grum Daniel F; Papadimos Thomas J

2008-01-01

 
 
 
 
341

Determination of 210Po in tea, mat and their infusions and its annual intake by Syrians  

International Nuclear Information System (INIS)

[en] Polonium-210 was determined in 34 kinds of imported tea and 9 kinds of mat collected from the Syrian local market. The 210Po concentration was found to vary from 5.5 to 39 Bq x kg-1 and 47 to 82 Bq x kg-1 in tea and mat samples, respectively. In addition 210Po was also determined in tea and mat infusions where different infusion conditions have been examined: amount, temperature and infusion time. The results have shown that the amount of 210Po transferred from tea and mat leaves to the aqueous extract ranged from 9 to 21% and 3 to 15%, respectively. The annual intake of 210Po by Syrians due to tea consumption and mat infusions was calculated and found to be 9 Bq and 151 Bq for tea and mat respectively: washing of mat with warm water is recommended before preparation the infusions to decrease the annual intake of 210Po. (author)

2004-01-01

342

Strategies for the delivery of multiple collinear infusion clouds in convection-enhanced delivery in the treatment of Parkinson's disease.  

UK PubMed Central (United Kingdom)

BACKGROUND: Delivery of multiple collinear payloads utilizing convection-enhanced delivery (CED) has historically been performed by retraction of a needle or catheter from the most distal delivery site. Few studies have addressed end-infusion morphology and associated payload reflux in stacked and collinear infusions, and studies comparing the advancement with the retraction mode are lacking. OBJECTIVE: To compare advancement versus retraction mode infusion results. METHODS: Infusion cloud pairs were created with the advancement and retraction technique in agarose gel using both open end-port SmartFlow (SF) and valve tip (VT) catheter infusion systems. Backflow, radius of infusion, and morphology were assessed. RESULTS: Infusions with the SF catheter, in contrast to the VT catheter, exhibited significantly more backflow in retraction mode at the shallow infusion site. Infusion morphology differed with the second infusion after retraction: the infusate at the proximal site first filling the channel left by the retraction and then being convected into gel in a pronouncedly non-spherical shape during the second infusion. CONCLUSIONS: Significant differences in cloud morphology were noted with respect to external catheter geometry with retraction versus penetration between infusions in an agarose gel model of the brain. Further study is warranted to determine optimal protocols for human clinical trials employing CED with multiple collinear payloads.

Sillay K; Hinchman A; Kumbier L; Schomberg D; Ross C; Kubota K; Brady M; Brodsky E; Miranpuri G; Raghavan R

2013-01-01

343

Intravascular infusion of lipid into ewes stimulates production of progesterone and prostaglandin.  

UK PubMed Central (United Kingdom)

Effects of infusion of a lipid emulsion into ewes during mid-to late diestrus on serum concentrations of total cholesterol (TC), progesterone (P4), prostaglandin (PG) F2 alpha metabolite (PGFM), and PGE2, and on ovulation rate were examined. In experiment 1, ewes received infusions of either saline (S, n = 3) or soybean oil emulsion (SB, n = 3) for 5 h on each of Days 9-13 of the estrous cycle. In experiment 2, ewes received infusions of either S (n = 4), SB (n = 5), or olive oil emulsion (OO, n = 5) for 5 h on each of Days 9 through 15 of the estrous cycle. In both experiment 1 and experiment 2, infusion of lipid increased serum concentrations of TC and P4, which declined with time after infusion was terminated (treatment x hour interaction, experiment 1: TC, p < 0.01, P4, p < 0.01; experiment 2: TC, p < 0.01, P4, p < 0.001). Serum PGFM and PGE2 concentrations were greater in lipid-infused ewes than in controls on Days 13 through 15 (treatment x hour interaction; p < 0.03, p < 0.001, respectively). Duration of the estrous cycle was shortened in OO-infused ewes (16.2 +/- 0.4 days) compared with that of SB- and S-infused ewes (17.2 +/- 0.2 and 18.0 +/- 0.0 days, respectively; p < 0.01). Numbers of corpora lutea and follicles, and diameter of follicles > 4 mm did not differ among treatment groups on Day 14 of the succeeding cycle after infusion. These data indicate that lipid infusion stimulated increases in serum concentrations of TC, P4, and prostaglandins and may shorten the estrous cycle.

Burke JM; Carroll DJ; Rowe KE; Thatcher WW; Stormshak F

1996-07-01

344

Standard versus prolonged doripenem infusion for treatment of gram-negative infections.  

UK PubMed Central (United Kingdom)

BACKGROUND: Doripenem is the most recently introduced carbapenem, with a broad spectrum of antimicrobial activity. Preliminary data indicated that activity is optimized by maximizing the time that serum concentration remains above the minimum inhibitory concentration; however, limited clinical data are available to support this approach. OBJECTIVE: To compare clinical outcomes before and after implementation of a hospital-wide initiative extending the duration of infusion for doripenem from 1 hour (standard) to 4 hours (prolonged). METHODS: This retrospective, quasi-experimental study compared clinical outcomes associated with doripenem administered as a 1-hour infusion versus a 4-hour infusion for treatment of suspected or documented infections caused by gram-negative organisms. Outcomes were assessed for the entire cohort, as well as for the subpopulation of patients admitted to the intensive care unit. RESULTS: Two hundred patients were included; 106 patients received doripenem via standard infusion and 94 patients via prolonged infusion. No significant differences were noted between the treatment groups in clinical success, length of stay, or duration of treatment when the entire cohort was evaluated. In the critically ill subgroup, pneumonia, standard-infusion doripenem, and concomitant bacteremia were independent predictors of clinical failure (adjusted odds ratio [95% CI] 7.8 [2.4-25.6], 5.5 [1.6-18.7], and 7.0 [1.6-31.3], respectively). Additionally, critically ill patients who received doripenem via standard infusion were significantly more likely to experience recurrence of infection or death within 90 days. No significant differences were noted in length of stay or duration of bacteremia. CONCLUSIONS: The duration of infusion did not significantly impact outcomes when the entire cohort was compared; however, prolonged infusion of doripenem was associated with significantly improved clinical outcomes among critically ill patients. These findings support the use of prolonged infusion of doripenem for critically ill patients.

Hsaiky L; Murray KP; Kokoska L; Desai N; Cha R

2013-07-01

345

Systemic and regional hemodynamic effects of enalaprilat infusion in experimental normotensive sepsis  

Directory of Open Access Journals (Sweden)

Full Text Available Angiotensin-converting enzyme inhibitors have been shown to improve splanchnic perfusion in distinct shock states. We hypothesized that enalaprilat potentiates the benefits of early fluid resuscitation in severe experimental sepsis, particularly in the splanchnic region. Anesthetized and mechanically ventilated mongrel dogs received an intravenous infusion of live Escherichia coli over a period of 30 min. Thereafter, two interventions were performed: fluid infusion (normal saline, 32 mL/kg over 30 min) and enalaprilat infusion (0.02 mg kg-1 min-1 for 60 min) in randomized groups. The following groups were studied: controls (fluid infusion, N = 4), E1 (enalaprilat infusion followed by fluid infusion, N = 5) and E2 (fluid infusion followed by enalaprilat infusion, N = 5). All animals were observed for a 120 min after bacterial infusion. Mean arterial pressure, cardiac output (CO), portal vein blood flow (PVBF), systemic and regional oxygen-derived variables, and lactate levels were measured. Rapid and progressive reductions in CO and PVBF were induced by the infusion of live bacteria, while minor changes were observed in mean arterial pressure. Systemic and regional territories showed a significant increase in oxygen extraction and lactate levels. Widening venous-arterial and portal-arterial pCO2 gradients were also detected. Fluid replacement promoted transient benefits in CO and PVBF. Enalaprilat after fluid resuscitation did not affect systemic or regional hemodynamic variables. We conclude that in this model of normotensive sepsis inhibition of angiotensin-converting enzyme did not interfere with the course of systemic or regional hemodynamic and oxygen-derived variables.

L. Rahal; A.G. Garrido; R.J. Cruz Jr.; M. Rocha e Silva; L.F. Poli-de-Figueiredo

2006-01-01

346

Systemic and regional hemodynamic effects of enalaprilat infusion in experimental normotensive sepsis  

Scientific Electronic Library Online (English)

Full Text Available Abstract in english Angiotensin-converting enzyme inhibitors have been shown to improve splanchnic perfusion in distinct shock states. We hypothesized that enalaprilat potentiates the benefits of early fluid resuscitation in severe experimental sepsis, particularly in the splanchnic region. Anesthetized and mechanically ventilated mongrel dogs received an intravenous infusion of live Escherichia coli over a period of 30 min. Thereafter, two interventions were performed: fluid infusion (norma (more) l saline, 32 mL/kg over 30 min) and enalaprilat infusion (0.02 mg kg-1 min-1 for 60 min) in randomized groups. The following groups were studied: controls (fluid infusion, N = 4), E1 (enalaprilat infusion followed by fluid infusion, N = 5) and E2 (fluid infusion followed by enalaprilat infusion, N = 5). All animals were observed for a 120 min after bacterial infusion. Mean arterial pressure, cardiac output (CO), portal vein blood flow (PVBF), systemic and regional oxygen-derived variables, and lactate levels were measured. Rapid and progressive reductions in CO and PVBF were induced by the infusion of live bacteria, while minor changes were observed in mean arterial pressure. Systemic and regional territories showed a significant increase in oxygen extraction and lactate levels. Widening venous-arterial and portal-arterial pCO2 gradients were also detected. Fluid replacement promoted transient benefits in CO and PVBF. Enalaprilat after fluid resuscitation did not affect systemic or regional hemodynamic variables. We conclude that in this model of normotensive sepsis inhibition of angiotensin-converting enzyme did not interfere with the course of systemic or regional hemodynamic and oxygen-derived variables.

Rahal, L.; Garrido, A.G.; Cruz Jr., R.J.; Rocha e Silva, M.; Poli-de-Figueiredo, L.F.

2006-09-01

347

Infusion of a lipid emulsion in healthy men decreases the serotonergic response.  

UK PubMed Central (United Kingdom)

Subjects with obesity and insulin resistance display a low response to a serotonergic challenge test. One of the hallmarks of obesity and insulin resistance is elevated plasma free fatty acids (FFAs). We hypothesize that increasing plasma FFA by infusion of a lipid emulsion, may be a contributing component leading to decreased serotonergic responsivity in healthy young men. Ten lean healthy men, 23.6 ± 5.0 years and BMI 22.6 ± 1.9 kg/m(2), were included. Serotonergic responsivity was assessed using the prolactin response to infusion with citalopram, a selective serotonin reuptake inhibitor, which is a validated tool to assess serotonergic tone. All participants received a lipid/heparin emulsion (Intralipid) infusion during 6 h. Saline infusion was used as a control. To evaluate a possible effect of heparin per se on prolactin, four out of the ten subjects also received heparin only during 6 h without the serotonergic challenge test. Plasma prolactin increased by 74.3 ± 15.5% during saline infusion. Intralipid infusion increased plasma FFA from 0.5 ± 0.05 to 2.3 ± 0.2 mmol/l (p < 0.001). The increase in plasma prolactin during Intralipid infusion was significantly lower (39.3 ± 10%; p < 0.001 compared to saline infusion). Heparin infusion per se increased plasma prolactin by 14.0 ± 1.9%. We found that during the Intralipid infusion with concomitant high plasma FFA levels the serotonergic response was decreased in healthy young men. Higher FFA levels may be the mediator of the decreased serotonergic response reported in patients with insulin resistance and obesity.

Sondermeijer BM; Klein Twennaar CF; Kastelein JJ; Franssen EJ; Hutten BA; Dallinga-Thie GM; Stroes ES; Fliers E; Twickler MT; Serlie MJ

2012-01-01

348

Behaviour of homologous 125I fibrinogen after thrombin and ancrod infusion in rabbits  

International Nuclear Information System (INIS)

[en] The behaviour of radioactively labelled fibrinogen after infusion of thrombin or ancrod is investigated. Common factors and differences in the behaviour of fibrinogen after infusion of these two enzymes, which act proteolytically on the fibrinogen, are dealt with. Rabbits received an i.v. injection of homologous 125I-fibrinogen 3 days before ancrod or thrombin infusion. On the day of the experiments, one group of animals received an ancrod infusion (1.5 U/kg body weight for 30 minutes), the other a thrombin infusion (600 U/kg body weight for 60 minutes). Intravenous ancrod and thrombin infusions lowered the fibrinogen level to 30% or 50% of the initial value due to intravascular coagulation. About 50% of the 125I fibrinogen was transformed after ancrod exposure into a non-coagulating fraction of fibrinogen derivatives which produces no fibrinolytic decomposition products. (orig./AJ)[de] Das Verhalten von radioaktivmarkiertem Fibrinogen nach Infusion von Thrombin bzw. Ancrod wird untersucht. Gemeinsamkeiten und Unterschiede in dem Verhalten von Fibrinogen nach Infusion dieser beiden am Fibrinogen proteolytisch angreifenden Enzyme werden herausgestellt. Kaninchen wurde 3 Tage vor Ancord- bzw. Thrombin-Infusion homologenes 125J-Fibrinogen intravenoes injiziert. Das Verhalten dieses Fibrinogens wurde ueber die naechsten drei Tage verfolgt. Am Versuchstag wurde einer Gruppe von Kaninchen Ancrod (1,5 U/kg Koerpergewicht ueber 30 Min.) und einer zweiten Gruppe Thrombin (600 U/kg Koerpergewicht ueber 60 Min.) infundiert. Die intravenoese Ancrod- bzw. Thrombin-Infusion liess den Fibrinogenspiegel durch intravaskulaere Gerinnung auf 30% bzw. 50% des Ausgangswertes absinken. Etwa 50% des 125J-Fibrinogens wurde nach Ancrodeinwirkung in eine nicht gerinnbare Fraktion von Fibrinogenderivaten ueberfuehrt, die keine fibrinolytischen Abbauprodukte darstellt. (orig./AJ)

1977-01-01

349

Utilities associated with subcutaneous injections and intravenous infusions for treatment of patients with bone metastases  

Science.gov (United States)

Introduction Although cost-utility models are often used to estimate the value of treatments for metastatic cancer, limited information is available on the utility of common treatment modalities. Bisphosphonate treatment for bone metastases is frequently administered via intravenous infusion, while a newer treatment is administered as a subcutaneous injection. This study estimated the impact of these treatment modalities on health state preference. Methods Participants from the UK general population completed time trade-off interviews to assess the utility of health state vignettes. Respondents first rated a health state representing cancer with bone metastases. Subsequent health states added descriptions of treatment modalities (ie, injection or infusion) to this basic health state. The two treatment modalities were presented with and without chemotherapy, and infusion characteristics were varied by duration (30 minutes or 2 hours) and renal monitoring. Results A total of 121 participants completed the interviews (52.1% female, 76.9% white). Cancer with bone metastases had a mean utility of 0.40 on a standard utility scale (1 = full health; 0 = dead). The injection, 30-minute infusion, and 2-hour infusion had mean disutilities of ?0.004, ?0.02, and ?0.04, respectively. The mean disutility of the 30-minute infusion was greater with renal monitoring than without. Chemotherapy was associated with substantial disutility (?0.17). When added to health states with chemotherapy, the mean disutilities of injection, 30-minute infusion, and 2-hour infusion were ?0.02, ?0.03, and ?0.04, respectively. The disutility associated with injection was significantly lower than the disutility of the 30-minute and 2-hour infusions (P < 0.05), regardless of chemotherapy status. Conclusion Respondents perceived an inconvenience with each type of treatment modality, but injections were preferred over infusions. The resulting utilities may be used in cost-utility models examining the value of treatments for the prevention of skeletal-related events in patients with bone metastases.

Matza, Louis S; Cong, Ze; Chung, Karen; Stopeck, Alison; Tonkin, Katia; Brown, Janet; Braun, Ada; Van Brunt, Kate; McDaniel, Kelly

2013-01-01

350

Renal medullary interstitial infusion of diltiazem alters sodium and water excretion in rats.  

UK PubMed Central (United Kingdom)

The role of renal papillary blood flow in regulation of fluid and electrolyte excretion was examined. The effects of an acute infusion of diltiazem (5 micrograms.kg-1 x min-1) into the renal medullary interstitium on papillary blood flow and sodium and water excretion were studied. Changes of renal blood flow were measured using an electromagnetic flow probe. Cortical and papillary blood flows were measured using laser-Doppler flowmetry. Renal and cortical blood flows were unchanged during medullary interstitial infusion of diltiazem, but papillary blood flow increased 26% (P < 0.05) and remained elevated for 1 h after diltiazem infusion was discontinued. Glomerular filtration rate (GFR) of the infused kidney increased by 21% from a control of 1.0 +/- 0.1 ml.min-1 x g-1 during infusion of diltiazem (P < 0.05), but it returned to control after diltiazem infusion was stopped. Urine flow and sodium excretion increased by 70% (P < 0.05), and fractional sodium excretion rose from 1.5 +/- 0.2 to 2.4 +/- 0.3% of the filtered load during the hour after diltiazem infusion. Renal blood flow, cortical and papillary blood flow, GFR, urine flow, and sodium excretion in the 0.9% sodium chloride vehicle-infused kidney were not significantly altered during the experiment. Intravenous infusion of the same dose of diltiazem (5 micrograms.kg-1 x min-1) increased GFR by 22%, but had no effect on urine flow and sodium excretion. These results indicate that renal medullary interstitial infusion of diltiazem selectively increased renal papillary blood flow, which was associated with an increase of sodium and water excretion.

Lu S; Roman RJ; Mattson DL; Cowley AW Jr

1992-11-01

351

Comparative pharmacokinetics, pharmacodynamics, and tolerability of ertapenem 1 gram/day administered as a rapid 5-minute infusion versus the standard 30-minute infusion in healthy adult volunteers.  

UK PubMed Central (United Kingdom)

STUDY OBJECTIVE: To compare ertapenem pharmacokinetics, pharmacodynamics, and tolerability when administered as a rapid 5-minute infusion to the standard 30-minute infusion. DESIGN: Prospective, randomized, crossover pharmacokinetic study. SETTING: Clinical research center. SUBJECTS: Twelve healthy adult volunteers. INTERVENTION: Each subject received ertapenem 1 g intravenously, administered either as a rapid 5-minute infusion or the standard 30-minute infusion, every 24 hours for 3 days (first phase); after a 4-day washout period, each subject then received the other infusion every 24 hours for 3 days (second phase). MEASUREMENTS AND MAIN RESULTS: Plasma samples were collected after the first and third (steady-state) doses of each study phase, and protein binding was assessed by use of ultrafiltration. Pharmacokinetic analyses were conducted using noncompartmental and compartmental methods. A 5000-subject Monte Carlo simulation was used to assess the probability of target attainment for free drug concentration remaining above the minimum inhibitory concentration (MIC) for 40% or greater of the dosing interval (40% fT > MIC) over an MIC range. Ertapenem was well tolerated and adverse events were similar for both infusions. The ertapenem steady-state mean ± SD maximum concentrations were 193.3 ± 43.3 and 165.7 ± 20.4 mg/L for the 5- and 30-minute infusions, respectively; the mean ± SD areas under the concentration-time curves from 0-24 hours were 561.2 ± 77.0 and 531.3 ± 56.9 ?g · hr/ml (geometric mean ratio 1.008, 90% confidence interval 0.999-1.017), respectively. Protein binding was concentration dependent (range 87.9-98.9%). A two-compartment model best described ertapenem pharmacokinetics with the following parameter estimates: clearance 1.89 ± 0.19 L/hr, volume of central compartment 5.04 ± 0.56 L, and transfer constants k12 0.43 ± 0.08/hr and k21 0.44 ± 0.07/hr. The probabilities of target attainment for 5- and 30-minute infusions were 97.0% and 97.9% at an MIC of 0.25 mg/L and 1.7% and 2.8% at an MIC of 0.5 mg/L, respectively. CONCLUSION: Ertapenem administered as a rapid 5-minute infusion provides a well tolerated, bioequivalent, and pharmacodynamically equivalent regimen to the 30-minute infusion at clinically relevant MICs.

Wiskirchen DE; Housman ST; Quintiliani R; Nicolau DP; Kuti JL

2013-03-01

352

Arrhythmias during and after zoledronic acid infusion patients with bone metastasis.  

Science.gov (United States)

Zoledronic acid (ZA) is one of the important bisphosphonates which is widely used in bone metastatic cancer and osteoporotic patients. In a few studies, it has been reported that treatment with bisphosphonates was associated with an increased risk of atrial fibrillation. We aimed to evaluate the arrhythmias that developed during and immediately after infusion of the ZA. Fifty-two bone metastatic patients were included in the study group. All patients had 24-h Holter monitorization during the first dose ZA infusion day. All of the patients had 4-h basal cardiac rhythm records before ZA infusion and about 19 h after infusion. A short survey including demographic data and past medical history has been completed. None of patients had clinically important arrhythmias before ZA infusion. We divided arrhythmias into two groups as supraventricular and ventricular. We evaluated arrhythmias in pre-infusion, during infusion, and post-infusion periods. ZA was administered 4 mg intravenously (IV) in 15 min. Thirty-three of patients (63.5 %) were male and 19 (36.5 %) patients were female. Mean age of the patients was 53.9 ± 11.8 years. Most frequent cancers were breast (25 %) and lung cancer (15.3 %). Twelve (23 %) patients had history of mediastinal radiotherapy. In basal records, we detected that twenty-four (46 %) of patients had supraventricular premature complexes (SVPC) or ventricular premature complexes (VPC). Fifteen (28.8 %) of patients had SVPC and fourteen (26.9 %) had VPC during infusion period. After infusion period, 48 (92.3 %) of patients had SVPC and 41 (78.8 %) had VPC. Only 3 patients had no arrhythmia after infusion. Three patients had sinus arrhythmia and two had Mobitz type 2 atrioventricular blocks after infusion. One patient, who had no history of comorbidities and had SVPC in the basal records, developed atrial fibrillation that was refractory to medical cardioversion after 10 days of seventh dose of ZA infusion. In this study, we found that both SVPC and VPC increased in cancer patients treated with ZA. Furthermore, ZA may induce clinically important arrhythmias. PMID:23690271

Yazici, Ozan; Aksoy, Sercan; Ucar, Ozgul; Ozdemir, Nuriye; Demir, Mevlut; Sendur, Mehmet Ali Nahit; Arik, Zafer; Yaman, Sebnem; Eren, Tulay; Uncu, Dogan; Zengin, Nurullah

2013-05-21

353

Comparative dose accuracy of durable and patch insulin infusion pumps.  

UK PubMed Central (United Kingdom)

BACKGROUND: As all major insulin pump manufacturers comply with the international infusion pump standard EN 60601-2-24:1998, there may be a general assumption that all pumps are equal in insulin-delivery accuracy. This research investigates single-dose and averaged-dose accuracy of incremental basal deliveries for one patch model and three durable models of insulin pumps. METHOD: For each pump model, discrete single doses delivered during 0.5 U/h basal rate infusion over a 20 h period were measured using a time-stamped microgravimetric system. Dose accuracy was analyzed by comparing single doses and time-averaged doses to specific accuracy thresholds (±5% to ±30%). RESULTS: The percentage of single doses delivered outside accuracy thresholds of ±5%, ±10%, and ±20% were as follows: Animas OneTouch® Ping® (43.2%, 14.3%, and 1.8%, respectively), Roche Accu-Chek® Combo (50.6%, 24.4%, and 5.5%), Medtronic Paradigm® Revel™/Veo™ (54.2%, 26.7%, and 6.6%), and Insulet OmniPod® (79.1%, 60.5%, and 34.9%). For 30 min, 1 h, and 2 h averaging windows, the percentage of doses delivered outside a ±15% accuracy were as follows: OneTouch Ping (1.0%, 0.4%, and 0%, respectively), Accu-Chek Combo (4.2%, 3.5%, and 3.1%), Paradigm Revel/Veo (3.9%, 3.1%, and 2.2%), and OmniPod (33.9%, 19.9%, and 10.3%). CONCLUSIONS: This technical evaluation demonstrates significant differences in single-dose and averaged-dose accuracy among the insulin pumps tested. Differences in dose accuracy were most evident between the patch pump model and the group of durable pump models. Of the pumps studied, the Animas OneTouch Ping demonstrated the best single-dose and averaged-dose accuracy. Further research on the clinical relevance of these findings is warranted.

Jahn LG; Capurro JJ; Levy BL

2013-07-01

354

A pharmacokinetic-pharmacodynamic model for duodenal levodopa infusion.  

UK PubMed Central (United Kingdom)

OBJECTIVE: The purpose of this work was to identify and estimate a population pharmacokinetic- pharmacodynamic model for duodenal infusion of a levodopa/carbidopa gel (Duodopa) to examine pharmacological properties of this treatment. METHODS: The modeling involved pooling data from 3 studies (on advanced Parkinson disease) and fixing some parameters to values found in literature. The first study involved 12 patients studied on 3 occasions each and was previously published. The second study involved 3 patients on 2 occasions. A bolus dose was given after a washout during night. Plasma samples and motor ratings (clinical assessment of motor function on a 7-point treatment response scale ranging from "very off" to "very hyperkinetic") were collected until the clinical effect returned to baseline. The third study involved 5 patients on 3 occasions receiving 5 different dose levels. Different structural models were evaluated using the nonlinear mixed-effects modeling program NONMEM VI. Population mean parameter values, and interindividual, interoccasion, and residual variabilities were estimated. RESULTS: Absorption of the levodopa/carbidopa gel can be adequately described with first-order absorption with bioavailability and lag time. Estimated population parameter values were a mean absorption time of 28.5 minutes, a lag time of 2.9 minutes, and a bioavailability of 88%. The pharmacodynamic model for motor ratings had the following population values: a half-life of effect delay of 21 minutes, a concentration at 50% effect of 1.55 mg/L, an Emax of 2.39 U on the treatment response scale, and a sigmoidicity of the Emax function of 11.6. CONCLUSIONS: For the typical unmedicated subject, it will take 51.4 minutes until the peak levodopa effect is reached after a bolus dose. This delay is, like the magnitude of the effect, highly variable in this patient group. The residual error magnitudes of 20% for levodopa concentrations and 0.92 U (SD) for motor ratings indicate that the models developed provide predictions of a relevant quality. The developed model may be a first step toward model-guided treatment individualization of duodenal infusion of levodopa.

Westin J; Nyholm D; Pålhagen S; Willows T; Groth T; Dougherty M; Karlsson MO

2011-03-01

355

UNIVERSAL SECTIONAL HOUSEHOLD DRYER  

UK PubMed Central (United Kingdom)

Invention herewith described refers to the universal sectional household dryer particularly applicable for the farm household and in dried herb and dietary product business. The sectional design and the energy solution with easy handling and adapting to the requirements are the main advantages as well as the competitive market price. In the technical section, there is mounted the heat source for solid fuel and the common fan to circulate air across the shelves in one or more sections for product drying. According to need, a predetermined adjustment can be performed in sections and shelves in accordance with the requirements of drying technology, as well as the assembling of the mounting duplex dryer with several sections.

CEROVINA BOJAN; CEROVINA ANDRIJA

356

Mechanized support section  

Energy Technology Data Exchange (ETDEWEB)

A mechanical support section is proposed consisting of a movable shroud and hinged cover, hydaulic jacks and stands, and connecting hydraulic lines. The shroud is equipped with a mechanism that ensures its proper positioning. The support design is simplified, and the section's reliability enhanced, by using two hydraulic cylinders and associated hydraulic connections to position the shroud. One of the hydraulic cylinders is mounted between the support section and the shroud cover while the other is deployed within the mobile section of the shroud itself.

Dubinin, V.Ye.; Namestnikov, Yu.I.; Romanov, P.D.; Zaykin, Ye.K.

1982-01-01

357

Intravascular infusion of lipid into ewes stimulates production of progesterone and prostaglandin.  

Science.gov (United States)

Effects of infusion of a lipid emulsion into ewes during mid-to late diestrus on serum concentrations of total cholesterol (TC), progesterone (P4), prostaglandin (PG) F2 alpha metabolite (PGFM), and PGE2, and on ovulation rate were examined. In experiment 1, ewes received infusions of either saline (S, n = 3) or soybean oil emulsion (SB, n = 3) for 5 h on each of Days 9-13 of the estrous cycle. In experiment 2, ewes received infusions of either S (n = 4), SB (n = 5), or olive oil emulsion (OO, n = 5) for 5 h on each of Days 9 through 15 of the estrous cycle. In both experiment 1 and experiment 2, infusion of lipid increased serum concentrations of TC and P4, which declined with time after infusion was terminated (treatment x hour interaction, experiment 1: TC, p 4 mm did not differ among treatment groups on Day 14 of the succeeding cycle after infusion. These data indicate that lipid infusion stimulated increases in serum concentrations of TC, P4, and prostaglandins and may shorten the estrous cycle. PMID:8793072

Burke, J M; Carroll, D J; Rowe, K E; Thatcher, W W; Stormshak, F

1996-07-01

358

Elimination of infusion bubbles and uncontrolled reflux in the alcon constellation vitrectomy vision system.  

UK PubMed Central (United Kingdom)

PURPOSE: To identify the sources and management of 2 problems associated with the Alcon Constellation Vitrectomy (Alcon Laboratories, Inc) System: 1) infusion bubbles and 2) uncontrolled reflux. METHODS: Surgical and analytical videos were evaluated to identify the source of intraoperative bubbles, which localized to the duckbill valve (DV). Intraoperatively, the authors modified the infusion tubing and its control by removing the DV. The DV was repurposed as a one-way valve to block reflux originating from the vitrectomy console. RESULTS: Twenty consecutive 23-gauge vitrectomies in 20 eyes of 20 subjects from 2 surgeons (S.R.R. and E.H.S.) were reviewed. Infusion bubbles at the DV developed with each transitory tubing pressure drop upon opening of the infusion clamp. Removal of the DV from the infusion line eliminated infusion bubbles in 20 consecutive 23-gauge cases. Adding a one-way valve, which was fashioned from the DV, to the aspiration tubing, resulted in elimination of infusion bubbles and console-originated reflux in 20 eyes. Placement of the DV to block reflux eliminated both uncontrolled and purposeful console-originated reflux. CONCLUSION: Intraoperative modification of Constellation tubing may eliminate two potentially harmful problems until manufacturer correction is instituted. Because the authors' modified connections represent off-label connectivity, the manufacturer cannot contact potentially affected surgeons or suggest temporary alternative connectivity improvements.

Russell SR; Sohn EH; Boldt HC; Folk JC; Tarantola RM; Kay CN; Mahajan VB

2013-04-01

359

Interstitial transport and transvascular fluid exchange during infusion into brain and tumor tissue.  

UK PubMed Central (United Kingdom)

A model of convection-enhanced delivery in brain and neoplastic tissue is presented that includes transvascular fluid exchange in addition to interstitial fluid transport. Measured values for the relevant material parameters are compiled from published literature. The transient distributions of interstitial fluid pressure and fluid velocity resulting from infusion into brain tissue and into a tissue-isolated tumor are derived, in addition to the steady-state distribution of interstitial fluid pressure and fluid velocity resulting from infusion into a tumor with a necrotic core. The analytic solutions suggest that (1) the distributions of both pressure and fluid velocity are very sensitive to the ratio of vascular conductivity and hydraulic conductivity; (2) in brain tissue, the convective fluid velocity is significant (within three orders of magnitude of the peak value, for example) for a large number of infusion catheter diameters away from the infusion site, whereas in neoplastic tissue the convective velocity is significant for a small number of infusion catheter diameters away from the infusion site; (3) the presence of a necrotic core substantially increases the convective fluid velocity in its vicinity; and (4) infusion proximal to a tumor is greatly impeded by the outward flow at the tumor's periphery. These and related findings are discussed in terms of their relevance to the treatment of tumors.

Smith JH; Humphrey JA

2007-01-01

360

Antropyloroduodenal, cholecystokinin and feeding responses to pulsatile and non-pulsatile intraduodenal lipid infusion.  

Science.gov (United States)

The contribution of the pulsatile nature of gastric emptying to small intestinal feedback mechanisms modulating antropyloroduodenal motility and appetite is unknown. On separate days, eight healthy male volunteers (18-34 years) received randomized, single-blind, intraduodenal (ID) infusions of 10% Intralipid (2 kcal min(-1)), either continuously [CID], or in a pulsatile manner [PID] (5 s on/15 s off) and 0.9% saline (control) administered continuously, each at a rate of 1.8 mL min(-1) for 3 h. During each infusion, subjective ratings of appetite were assessed and antropyloroduodenal pressures recorded with a 16-lumen manometric assembly incorporating a pyloric sleeve sensor. Plasma cholecystokinin was measured from blood collected at regular intervals throughout the infusion. At the end of each infusion the manometric assembly was removed, subjects were offered a buffet meal and the energy and macronutrient content of the meal was measured. Both ID lipid infusions stimulated isolated pyloric pressure waves (IPPWs) (P 0.05, CID vs. PID). Both intraduodenal lipid infusions decreased hunger (P < 0.05), increased fullness (P < 0.05) and reduced energy intake (P < 0.05) when compared with controls; again there was no difference between CID and PID lipid. We conclude that at the infusion rate of similar 2 kcal min(-1), the acute effects of intraduodenal lipid on antropyloroduodenal pressures, plasma CCK concentration and appetite are not modified by a pulsatile mode of lipid delivery into the duodenum. PMID:11874551

Vozzo, R; Su, Y-C; Fraser, R J; Wittert, G A; Horowitz, M; Malbert, C H; Shulkes, A; Volombello, T; Chapman, I M

2002-02-01

 
 
 
 
361

Glucagon infusion increases rate of purine synthesis de novo in rat liver  

Energy Technology Data Exchange (ETDEWEB)

Based on the parallel increases of glucagon, the second peak of hepatic cAMP, and the rate of purine synthesis de novo in the prereplicative period in regenerating rate liver after a 70% hepatectomy, it was hypothesized that glucagon is responsible for the increased rate of purine synthesis de novo. To test this hypothesis, the effect of glucagon or dibutyryl cAMP infusion on the rate of purine synthesis de novo in rat liver was studied. Glucagon infusion but not insulin or glucose infusion increased the rate of purine synthesis de novo, which was assayed by ({sup 14}C)glycine or ({sup 14}C)formate incorporation, by 2.7- to 4.3-fold. Glucagon infusion increased cAMP concentrations by 4.9-fold and 5-phosphoribosyl-1-pyrophosphate concentrations by 1.5-fold in liver but did not change the specific activity of amidophosphoribosyltransferase or purine ribonucleotide concentrations. Dibutyryl cAMP infusion also increased the rate of purine synthesis de novo by 2.2- to 4.0-fold. Because glucagon infusion increased the rate of purine synthesis de novo in the presence of unchanged purine ribonucleotide concentrations, it is concluded that glucagon after infusion or in animals after a 70% hepatectomy is playing an anabolic role to increase the rate of purine synthesis de novo by increasing cAMP and 5-phosphoribosyl-1-pyrophosphate concentrations.

Itakura, Mitsuo; Maeda, Noriaki; Tsuchiya, Masami; Yamashita, Kamejiro (Univ. of Tsukuba, Ibaraki (Japan))

1987-12-01

362

Glucagon infusion increases rate of purine synthesis de novo in rat liver  

International Nuclear Information System (INIS)

Based on the parallel increases of glucagon, the second peak of hepatic cAMP, and the rate of purine synthesis de novo in the prereplicative period in regenerating rate liver after a 70% hepatectomy, it was hypothesized that glucagon is responsible for the increased rate of purine synthesis de novo. To test this hypothesis, the effect of glucagon or dibutyryl cAMP infusion on the rate of purine synthesis de novo in rat liver was studied. Glucagon infusion but not insulin or glucose infusion increased the rate of purine synthesis de novo, which was assayed by [14C]glycine or [14C]formate incorporation, by 2.7- to 4.3-fold. Glucagon infusion increased cAMP concentrations by 4.9-fold and 5-phosphoribosyl-1-pyrophosphate concentrations by 1.5-fold in liver but did not change the specific activity of amidophosphoribosyltransferase or purine ribonucleotide concentrations. Dibutyryl cAMP infusion also increased the rate of purine synthesis de novo by 2.2- to 4.0-fold. Because glucagon infusion increased the rate of purine synthesis de novo in the presence of unchanged purine ribonucleotide concentrations, it is concluded that glucagon after infusion or in animals after a 70% hepatectomy is playing an anabolic role to increase the rate of purine synthesis de novo by increasing cAMP and 5-phosphoribosyl-1-pyrophosphate concentrations

1987-01-01

363

Dopamine infusion for postresuscitation blood pressure support after profound asphyxia in near-term fetal sheep.  

UK PubMed Central (United Kingdom)

Dopamine is commonly used for blood pressure support in the neonate, but has limited empirical evidence to support its use. We tested the hypothesis that after near-terminal asphyxia in utero, dopamine infusions would prevent secondary hypotension. Fetal sheep (122-129 days of gestation; term is 147 days) received umbilical cord occlusion for 15 min or sham occlusion (n = 5). If the mean arterial blood pressure fell below 90% of baseline within 6 h after occlusion, fetuses were randomized to either dopamine infusion starting at 4 ?g kg(-1) min(-1) and titrated according to mean arterial blood pressure up to a maximum of 40 ?g kg(-1) min(-1) (n = 5) or to the same volume of normal saline (n = 5). Dopamine infusion, initiated at a median of 180 min after occlusion (range 96-280 min), was associated with a marked but transient increase in mean arterial blood pressure and fall in femoral blood flow compared with saline. Terminal hypotension developed later in four of the five fetuses that received maximal dopamine infusions than in five of five receiving saline infusion [517 (range 240-715) versus 106 min (range 23-497) after the start of infusions, P < 0.05]. In conclusion, dopamine infusion delayed but did not prevent terminal hypotension after severe asphyxia.

Drury PP; Booth LC; Bennet L; Davidson JO; Wibbens B; Gunn AJ

2013-03-01

364

Dopamine infusion for postresuscitation blood pressure support after profound asphyxia in near-term fetal sheep.  

Science.gov (United States)

Dopamine is commonly used for blood pressure support in the neonate, but has limited empirical evidence to support its use. We tested the hypothesis that after near-terminal asphyxia in utero, dopamine infusions would prevent secondary hypotension. Fetal sheep (122-129 days of gestation; term is 147 days) received umbilical cord occlusion for 15 min or sham occlusion (n = 5). If the mean arterial blood pressure fell below 90% of baseline within 6 h after occlusion, fetuses were randomized to either dopamine infusion starting at 4 ?g kg(-1) min(-1) and titrated according to mean arterial blood pressure up to a maximum of 40 ?g kg(-1) min(-1) (n = 5) or to the same volume of normal saline (n = 5). Dopamine infusion, initiated at a median of 180 min after occlusion (range 96-280 min), was associated with a marked but transient increase in mean arterial blood pressure and fall in femoral blood flow compared with saline. Terminal hypotension developed later in four of the five fetuses that received maximal dopamine infusions than in five of five receiving saline infusion [517 (range 240-715) versus 106 min (range 23-497) after the start of infusions, P < 0.05]. In conclusion, dopamine infusion delayed but did not prevent terminal hypotension after severe asphyxia. PMID:23104935

Drury, Paul P; Booth, Lindsea C; Bennet, Laura; Davidson, Joanne O; Wibbens, Bert; Gunn, Alistair Jan

2012-10-26

365

Analysis of infusion pump error logs and their significance for health care.  

UK PubMed Central (United Kingdom)

Infusion therapy is one of the largest practised therapies in any healthcare organisation, and infusion pumps are used to deliver millions of infusions every year in the NHS. The aircraft industry downloads information from 'black boxes' to help design better systems and reduce risk; however, the same cannot be said about error logs and data logs from infusion pumps. This study downloaded and analysed approximately 360 000 hours of infusion pump error logs from 131 infusion pumps used for up to 2 years in one large acute hospital. Staff had to manage 260 129 alarms; this accounted for approximately 5% of total infusion time, costing about £1000 per pump per year. This paper describes many such insights, including numerous technical errors, propensity for certain alarms in clinical conditions, logistical issues and how infrastructure problems can lead to an increase in alarm conditions. Routine use of error log analysis, combined with appropriate management of pumps to help identify improved device design, use and application is recommended.

Lee PT; Thompson F; Thimbleby H

2012-04-01

366

Inhibition of prolactin secretion by low-dose dopamine infusion in patients with hyperprolactinaemia.  

UK PubMed Central (United Kingdom)

Dopamine inhibits the secretion of prolactin from the pituitary. We have examined the relation between plasma dopamine and serum prolactin in 12 patients with hyperprolactinaemia during the infusion of dopamine at low doses (0.01, 0.1 and 1 microgram/kg/min). Plasma dopamine levels were raised from less than 100 pg/ml at the lowest rate of infusion to more than 20 000 pg/ml at the highest. Suppression of prolactin secretion was seen in some patients even at the lowest rate of infusion (0.01 microgram/kg/min); marked suppression of prolactin secretion (60%; 17--83%) was found at the intermediate dose (0.1 microgram/kg/min) in 11 of the 12 subjects with little further decrease in serum prolactin (70%; 50--87%) in those in whom the rate of dopamine infusion was increased ten-fold. One patient with the highest serum prolactin (82 500 mu/l) showed no decrease in prolactin either at the lowest or intermediate rates of dopamine infusion. Serum prolactin levels returned to values similar to or greater than basal on cessation of dopamine infusion. Infusion of dopamine at doses much lower than previously used in man exposes the pituitary to a concentration of dopamine sufficient to suppress prolactin secretion. These observations have important implications in understanding the pathophysiology of prolactin secretion from the pituitary gland and for future investigations of the control of hormone release by dopamine.

Connell JM; Padfield PL; Bunting EA; Ball SG; Inglis GC; Beastall GH; Teasdale GM; Davies DL

1983-05-01

367

Transarterial Infusion Chemotherapy Using Cisplatin-Lipiodol Suspension With or Without Embolization for Unresectable Hepatocellular Carcinoma  

International Nuclear Information System (INIS)

[en] We evaluate the long-term prognosis and prognostic factors in patients treated with transarterial infusion chemotherapy using cisplatin-lipiodol (CDDP/LPD) suspension with or without embolization for unresectable hepatocellular carcinoma (HCC). Study subjects were 107 patients with HCC treated with repeated transarterial infusion chemotherapy alone using CDDP/LPD (adjusted as CDDP 10mg/LPD 1ml). The median number of transarterial infusion procedures was two (range, one to nine), the mean dose of CDDP per transarterial infusion chemotherapy session was 30 mg (range, 5.0-67.5 mg), and the median total dose of transarterial infusion chemotherapy per patient was 60 mg (range, 10-390 mg). Survival rates were 86% at 1 year, 40% at 3 years, 20% at 5 years, and 16% at 7 years. For patients with >90% LPD accumulation after the first transarterial infusion chemotherapy, rates were 98% at 1 year, 60% at 3 years, and 22% at 5 years. Multivariate analysis identified >90% LPD accumulation after the first transarterial infusion chemotherapy (p = 0.001), absence of portal vein tumor thrombosis (PVTT; p

2009-01-01

368

Home infusion program for Fabry disease: experience with agalsidase alfa in Argentina.  

UK PubMed Central (United Kingdom)

Fabry disease is an X-linked lysosomal storage disorder caused by inherited deficiency of the enzyme a-galactosidase A. Enzyme replacement treatment using agalsidase alfa significantly reduces pain, improves cardiac function and quality of life, and slows renal deterioration. Nevertheless, it is a life-long treatment which requires regular intravenous infusions and entails a great burden for patients. Our objective was to evaluate retrospectively the safety and tolerability of the home infusion of agalsidase alfa in patients with Fabry disease in Argentina. We evaluated all the patients with Fabry disease who received home infusion with agalsidase alfa 0.2 mg/kg between January 2005 and June 2011. The program included 87 patients; 51 males (mean age: 30 years) and 36 females (mean age: 34 years). A total of 5229 infusions (mean: 59 per patient; range: 1-150) were administered. A total of 5 adverse reactions were seen in 5 patients (5.7% of patients and 0.9% of the total number of infusions). All were mild in severity and resolved by reducing the rate of infusion and by using antihistaminics. All these 5 patients were positive for IgG antibodies, but none of them presented IgE antibodies and none suffered an anaphylactic shock. In our group 18 patients were switched from agalsidase beta to agalsidase alfa without complications. Home infusion with agalsidase alfa is safe, well tolerated and is associated to high compliance.

Kisinovsky I; Cáceres G; Coronel C; Reisin R

2013-01-01

369

Tachyphylaxis and sensitization to nicotine-induced tachycardiac and pressor effects after nicotine infusions.  

Science.gov (United States)

This work examined the effects of nicotine on mean arterial pressure and heart rate in non-anesthetized spinal rats. Nicotine (200 mg/kg) was administered as a single bolus, as infusions lasting 7.5, 15 or 30 min, and as a post-infusion bolus. A nicotine bolus increased pressure and rate. These effects were less marked as the rate of infusion decreased. The infusions affected differentially the effects of a subsequent bolus. Thus, while tachycardia was decreased, the blood pressure rise was increased. An initial transient bradycardia was observed after bolus administration, but not during infusions; this effect was unchanged after post-infusion boluses. Pharmacological analysis indicated that tachycardia and bradycardia were predominantly due to ganglionic stimulation, while adrenal and sympathetic nerve catecholamine release played a major role in the pressor response. These results indicate that slow nicotine infusions do not induce tachyphylaxis for all of the cardiovascular effects of a subsequent bolus, and that development of acute tolerance appears to depend on the mechanism of action of the response. PMID:9204607

Cruz, S L; Vidrio, H

1997-01-01

370

Continuous and extended infusions of ?-lactam antibiotics in the pediatric population.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To conduct a systematic review of available data on the use of extended or continuous infusion of ?-lactam and monobactam therapy in the pediatric population (aged 0-18 years). DATA SOURCES: A literature search was performed using PubMed (1975-May 2012), International Pharmaceutical Abstracts (1970-May 2012), and Web of Science (1977-May 2012) to identify studies for inclusion. In addition, reference citations from identified publications were reviewed. The following search terms were used: pediatric, children, neonate, infant, adolescent, ?-lactam, cephalosporin, carbapenem, penicillin, monobactam, continuous infusion, extended infusion, and/or prolonged infusion. Individual names of drugs in each class of antibiotics were also included in the search. STUDY SELECTION AND DATA EXTRACTION: Randomized controlled clinical trials, pharmacokinetic/pharmacodynamic studies, observational studies, and case reports involving pediatric patients who received extended or continuous infusion of ?-lactam or monobactam antibiotics were reviewed. Only English-language publications were included. DATA SYNTHESIS: One randomized controlled clinical trial, 5 pharmacokinetic studies, 2 pharmacodynamic studies using Monte Carlo simulation, 1 case series, and 7 case reports were included in the analysis. The cephalosporin class has been studied the most and currently represents the only clinical trial using a continuous infusion dosing strategy in pediatric patients. There is limited clinical evidence available to support the use of extended or continuous infusion of ?-lactam antibiotics in the pediatric population. Pharmacodynamic studies conducted in this population mirror the current evidence in adults for cefepime and meropenem. The single prospective clinical trial using continuous infusion of ceftazidime failed to demonstrate any clinical benefit over traditional dosing; however, there was equal efficacy. CONCLUSIONS: More well-designed prospective clinical trials are required to determine the role of extended or continuous infusion of ?-lactam antibiotics in treatment of pediatric patients.

Walker MC; Lam WM; Manasco KB

2012-11-01

371

Clinical experience with contrast infusion sonography as an Essure confirmation test.  

UK PubMed Central (United Kingdom)

OBJECTIVES: The purpose of this study was to assess the clinical experience, including the feasibility, safety, compliance, and efficacy, of contrast infusion sonography as an Essure (Conceptus Inc, Mountain View, CA) confirmation test. METHODS: A retrospective chart review and telephone survey were conducted at an academic multispecialty group. The study participants were women with Essure intervention who underwent contrast infusion sonography, transvaginal sonography, and hysterosalpingography as Essure confirmation tests. The main outcome measures included the feasibility, safety, compliance, and efficacy of contrast infusion sonography as a first-line Essure confirmation test. RESULTS: A total of 118 women had successful bilateral Essure placement. Of the 63 who consented to contrast infusion sonography, 53 (84.1%) had proper bilateral placement and tubal occlusion and were encouraged to rely on Essure. Four were suspected of having unilateral tubal patency; hysterosalpingography in 2 confirmed bilateral tubal occlusion, and 2 were noncompliant with second-line hysterosalpingography. Three patients suspected of having unsatisfactory or uncertain placement on initial transvaginal sonography were encouraged to undergo hysterosalpingography in lieu of contrast infusion sonography, which confirmed unsatisfactory placement in 2 and proper placement and occlusion in 1. Three contrast infusion sonographic procedures could not be completed because of technical issues; therefore, contrast infusion sonography was feasible in 95.2% of the patients (60 of 63). No notable adverse events occurred. Only 17 patients were noncompliant with any confirmation test, yielding an overall compliance rate of 86% (101 of 118). No pregnancies occurred during 669 woman-months of follow-up. The average reimbursement for contrast infusion sonography was US$251.78. CONCLUSIONS: Preliminary clinical data suggest that contrast infusion sonography is a feasible, safe, and accurate Essure confirmation test, which is well accepted by patients.

Connor VF

2011-06-01

372

[Pharmacokinetics of meropenem administered with prolonged infusion time in patients receiving continuous veno-venous hemofiltration].  

UK PubMed Central (United Kingdom)

OBJECTIVE: To demonstrate the pharmacokinetic profile of meropenem when administered by 3-hour infusion in patients undergoing continuous veno-venous hemofiltration (CVVH). METHODS: The study was conducted in 10 patients, who were treated with CVVH. Each subject received meropenem in 3-hour infusion of 500 mg every 6 hours. Blood samples were collected before infusion (0 hour) and 0.25, 0.5, 1, 1.5, 2, 3, 4, 5, 6 hours (just before the infusion of the next dose) after the beginning of the fourth infusion. The concentrations of meropenem in plasma were measured by high-performance liquid chromatography method, and mean serum meropenem concentration-time curve was plotted. RESULTS: Peak plasma drug concentrations measured 3 hours post-infusion were (25.05 ± 5.64) mg/L, and trough levels after 6 hours of infusion were (13.03 ± 3.01) mg/L. The area under the plasma concentration-time curve (AUC) was (118.42 ± 26.78) mg x h?¹ x L?². The elimination half-life (T1/2) was (3.74 ± 0.55) hours. The mean residence time (MRT) was (4.99 ± 0.84) hours. The volume of distribution (Vb) was (22.85 ± 9.85) L and clearance of meropenem (CL) was (4.49 ± 1.32) L/h. The percentage of time that the serum drug concentration was above the minimum inhibitory concentration (MIC) accounting for the interval time of infusion (%T>MIC) was 100% (MIC 8 mg/L) in all the 10 patients. CONCLUSION: Based on these data, we concluded that satisfactory pharmacodynamic parameters could be attained in CVVH patients treated with meropenem by a prolonged infusion time of 3 hours with a dosage of 500 mg for every 6 hours.

Bo SN; Li HL; Zhu X; Yao GQ; Hu YF; Zhai SD; Lu W; Wang SY; Xu YZ; He B

2012-03-01

373

[Evaluation of soft diets using freeze infusion in videofluorography].  

UK PubMed Central (United Kingdom)

A food developed at the Hiroshima Prefectural Food Technology Research Center, Hiroshima, Japan, has proved to be a boon in videofluorography. The food features decreased hardness with retained their shape due to being impregnated with macerating enzymes under reduced pressure after vegetables are defrosted. Samples were removed immediately from the enzyme solution after freeze infusion. All foods tested raging from carrots to chicken contasted well in videofluorography in an evaluation of swallowing in 107 subjects with dysphagia, results for carrots compared well with those for 33% iopamidol, jelly, and yogurt. Only a subjects showed silent aspiration with carrots, compared to 19 with 33% iopamidol. Among 70 subjects showing no residual jelly and/or yogurt, just 12-8 severe and 4 moderate-showed residual carrots in the pharyngeal space. In contrast, among 67 subjects showing no residual carrots in the pharyngeal spase, 9 moderate subjects showing no residual jelly and/or yogurt. We concluded foods such as carrots treated as stated following jelly and/or yogurt as new nutrition sources for subjects with dysphagia.

Hirai T; Fukushima N; Ono K; Hajima M; Katagiri Y; Masuda S

2010-03-01

374

Saline infusion sonohysterography versus hysteroscopy for uterine cavity evaluation  

Science.gov (United States)

BACKGROUND AND OBJECTIVES: The most frequent procedures performed on women with abnormal uterine bleeding are 2D and 3D ultrasound. The most common accepted approach for the management of abnormal uterine bleeding is 2D TV scan followed by therapeutic hysteroscopy. The purpose of this prospective study was to assess whether 3D saline infusion sonohysterography (3D SIS) could replace diagnostic hysteroscopy (DH) for the diagnosis of endometrial pathology, in patients with abnormal uterine bleeding. DESIGN AND SETTING: A prospective study in the ultrasound department of the Women's Specialized Hospital, King Fahad Medical City, Riyadh, Saudi Arabia from January 2008 to February 2010. PATIENTS AND METHODS: 0One hundred and one patients with abnormal uterine bleeding, suspected to have endometrial abnormality by 2D and 3D transvaginal scan, were prospectively studied. Of these, 55 patients had undergone both 3D SIS and DH, followed by verification of results with histopathology. RESULTS: Upon comparison of 3D SIS and DH individually with histopathology, specificity and sensitivity for 3D SIS were 67% and 100%, respectively, and for hysteroscopy 67% and 98%, respectively. In addition, the positive predictive value and negative predictive value were 98% and 100%, respectively, for 3D SIS, while for DH they were 98% and 67%, respectively. CONCLUSION: 3D SIS is a safe alternative to hysteroscopy. However, larger randomized controlled trials should be conducted to ascertain the validity and reliability of this advantageous, less-invasive procedure, for women with abnormal uterine bleeding, who require evaluation of the endometrial cavity.

Khan, Faryal; Jamaat, Sadia; Al-Jaroudi, Dania

2011-01-01

375

Propofol drip infusion anesthesia for MRI scanning: two case reports.  

Science.gov (United States)

The magnetic resonance imaging (MRI) room is a special environment. The required intense magnetic fields create unique problems with the use of standard anesthesia machines, syringe pumps, and physiologic monitors. We have recently experienced 2 oral maxillofacial surgery cases requiring MRI: a 15-year-old boy with developmental disability and a healthy 5-year-old boy. The patients required complete immobilization during the scanning for obtaining high-quality images for the best diagnosis. Anesthesia was started in the MRI scanning room. An endotracheal intubation was performed after induction with intravenous administration of muscle relaxant. Total intravenous anesthesia via propofol drip infusion (4-7 mg/kg/h) was used during the scanning. Standard physiologic monitors were used during scan pauses, but special monitors were used during scanning. In MRI scanning for oral maxillofacial surgery, general anesthesia, with the added advantage of having a secured airway, is recommended as a safe alternative to sedation especially in cases of patients with disability and precooperative chidren. PMID:23763561

Sasao-Takano, Mami; Misumi, Kan; Suzuki, Masayuki; Kamiya, Yoko; Noguchi, Izumi; Kawahara, Hiroshi

2013-01-01

376

Donor lymphocyte infusion in bone marrow transplantation therapy  

Directory of Open Access Journals (Sweden)

Full Text Available The dose escalation of chemo-radiotherapy that is achievable with stem cell transplantation is often insufficient to eradicate malignancy, and an associated immune-mediated graft-versus-malignancy effect may be equally important for many diseases. The most directly compelling evidence for its presence has been provided by the efficacy of donor lymphocyte infusions (DLI) in generating anti-tumor responses, particularly for relapsed chronic-phase CML. Response rates and durability appear lower with myeloma and AML/MDS, and minimal with ALL. There is relatively little data on indolent lymphoid malignancies. Issues that remain to be resolved include the precise nature of the effector cells and their target antigens, the best strategies for separating graft-versus-malignancy from graft-versus-host disease (GVHD) and their effect on the durability of responses, and the role of adjuvant chemotherapy/cytokines. Similar issues surround routine combination with nonmyeloablative transplantation protocols and preliminary data suggests that GVHD may continue to provide a major obstacle.

Mackinnon Stephen; Peggs Karl

2002-01-01

377

Granulomatous conduit for intrathecal infusion of morphine and bupivacaine.  

UK PubMed Central (United Kingdom)

OBJECTIVE: Intrathecal drug delivery systems (IT-DDSs) have gained more widespread use in patients with non-cancer-related pain, notably failed back surgery syndrome and spinal arachnoiditis. Secondary to the longer life spans of these patients, more complications have been discovered with IT-DDSs. With an estimated incidence of 1% to 3%, an uncommon but serious complication is that of granuloma formation. CASE REPORT: We describe a case of a 38-year-old woman with a malfunctioning IT-DDS containing morphine and bupivacaine. The device had stopped providing relief for several months because of presumed leakage from the connection site between the pump and the proximal catheter. The IT-DDS spontaneously resumed functioning. The IT-DDS was explanted for low battery life, upon which we discovered that the leakage site had been encapsulated by drug concretion and granuloma formation, thus providing a sealed conduit that reestablished drug flow between the pump and the catheter. CONCLUSIONS: This case report reinforces the view that the infusate is the causal agent of this lesion.

Webb DM; Schneider JR; Lober RM; Vender JR

2011-03-01

378

Electrochemical determination of antioxidant capacity of fruit tea infusions  

UK PubMed Central (United Kingdom)

Cyclic voltammograms (CV) taken to 800mV at a scan rate 100mVs?¹ were used to quantify electrochemical properties of antioxidants present in 10 fruit tea infusions as well as to deduce antioxidant capacity from the Q??? parameter (charge passed to 600mV). A pronounced anodic current peak observed at 440mV in all analysed fruit teas indicated that ortho-dihydroxy-phenol and gallate groups are the major contributors to the antioxidant capacity of investigated teas. Antioxidant composite index (ACI) was determined for each tea employing antioxidant capacity values from previous spectrophotometric determinations as well as the Q??? parameter derived from CV. A ranking of the most potent teas was obtained: the fruit tea containing a large portion of rose hip fruit exhibited the highest ACI and a CV with the most pronounced anodic current peak at 440mV pointing to the presence of ortho-dihydroxy-phenol and gallate group containing compounds. Strong positive correlation was established between antioxidant capacities deduced from CVs with those previously determined using established spectrophotometric techniques (FRAP, ABTS and DPPH assays).

Piljac-Žegarac Jasenka; Valek Lidija; Stip?evi? Tamara; Martinez Sanja

2010-08-01

379

Adverse events with continuous doxapram infusion against late postoperative hypoxaemia.  

DEFF Research Database (Denmark)

OBJECTIVE: A randomized double-blind controlled trial of doxapram versus placebo against late postoperative hypoxaemia was planned to include 40 patients (2 x 20). RESULTS: After inclusion of 18 patients a serious adverse event was encountered with development of a brain stem infarction in a 90-year-old woman receiving doxapram. At this point the randomization code was broken and we decided to terminate the trial. Three of nine patients receiving doxapram had had an adverse event whereas none of the patients receiving placebo had adverse events (P = 0.2). In the 18 patients studied, there was an insignificant trend towards higher mean oxygen saturation in the doxapram group, and a significantly higher minimum oxygen saturation and reduced number of hypoxaemic events on the first postoperative night. CONCLUSION: Although these preliminary data on the effect of doxapram on postoperative hypoxaemia seem promising, further studies on the effect of continuous nocturnal postoperative doxapram infusion on levels of arterial oxygen saturation should be postponed until more knowledge about the pharmacokinetics of doxapram in this particular clinical situation has been gathered.

Rosenberg, J; Kristensen, P A

1996-01-01

380

Acute cholecystitis: 137 patients studied by infusion tomography of the gallbladder.  

UK PubMed Central (United Kingdom)

Clinical experience with inflammatory cholecystopathy recognized in 137 patients studied by infusion tomography of the gallbladder is presented. Diagnostic accuracy was 96% in positive and 94% in negative histologically proven cases. Our results show that infusion tomography of the gallbladder is an accurate, rapid, and safe diagnostic aid in the evaluation of acute cholecystitis. In cases of chronic cholecystitis, infusion tomography may be confirmatory but should not be relied on as a final diagnostic test due to a high percentage of false negative cases.

Moncada R; Cardoso M; Danley R; Rodriguez J; Kimura K; Pickleman J; Brandly J

1977-10-01

 
 
 
 
381

Acute cholecystitis: 137 patients studied by infusion tomography of the gallbladder.  

Science.gov (United States)

Clinical experience with inflammatory cholecystopathy recognized in 137 patients studied by infusion tomography of the gallbladder is presented. Diagnostic accuracy was 96% in positive and 94% in negative histologically proven cases. Our results show that infusion tomography of the gallbladder is an accurate, rapid, and safe diagnostic aid in the evaluation of acute cholecystitis. In cases of chronic cholecystitis, infusion tomography may be confirmatory but should not be relied on as a final diagnostic test due to a high percentage of false negative cases. PMID:409225

Moncada, R; Cardoso, M; Danley, R; Rodriguez, J; Kimura, K; Pickleman, J; Brandly, J

1977-10-01

382

Changes in circulating blood volume after infusion of hydroxyethyl starch 6% in critically ill patients  

DEFF Research Database (Denmark)

The cardiovascular response to a volume challenge with hydroxyethyl starch (HES) (200/0.5) 6% depends on the relation between the volume of HES 6% infused and the expansion of the blood volume in critically ill patients. However, only relatively limited data exist on the plasma expanding effect of infusion of HES 6% in critically ill patients. The purpose of the study was to evaluate the variation in the expansion of the circulating blood volume (CBV) in critically ill patients after infusion of 500 ml of colloid (HES (200/0.5) 6%) using the carbon monoxide method.

Christensen, P; Andersson, J

2001-01-01

383

[Continuous infusion of ropivacaine has no effects on pyrolytic implant: a preliminary study in rats].  

UK PubMed Central (United Kingdom)

The aim of the study is to analyse the effects of ropivacaïne on a pyrolytic implant in bone surgery. Ten rats were operated with a pyrolytic implant placed at the hip after femoral head resection: five cases with continuous infusion of ropivacaïne and five cases with continuous infusion of sterile water. Six days after, all the implants were analysed: weight, length, width, thickness and global design. This work showed that ropivacaïne can be use as continuous infusion with pyrolytic implant. Other studies in human surgery are necessary.

Apard T; Lancigu R; Cronier P

2012-06-01

384

Sectional device handling tool  

Energy Technology Data Exchange (ETDEWEB)

Apparatus for remotely handling a device in an irradiated underwater environment includes a plurality of tubular sections interconnected end-to-end to form a handling structure, the bottom section being adapted for connection to the device. A support section is connected to the top tubular section and is adapted to be suspended from an overhead crane. Each section is flanged at its opposite ends. Axially retractable bolts in each bottom flange are threadedly engageable with holes in the top flange of an adjacent section, each bolt being biased to its retracted position and retained in place on the bottom flange. Guide pins on each top flange cooperate with mating holes on adjacent bottom flanges to guide movement of the parts to the proper interconnection orientation. Each section carries two hydraulic line segments provided with quick-connect/disconnect fittings at their opposite ends for connection to the segments of adjacent tubular sections upon interconnection thereof to form control lines which are connectable to the device and to an associated control console.

Candee, Clark B. (Monroeville, PA)

1988-07-12

385

Jet inclusive cross sections  

Energy Technology Data Exchange (ETDEWEB)

Minijet production in jet inclusive cross sections at hadron colliders, with large rapidity intervals between the tagged jets, is evaluated by using the BFKL pomeron. We describe the jet inclusive cross section for an arbitrary number of tagged jets, and show that it behaves like a system of coupled pomerons.

Del Duca, V.

1992-11-01

386

Jet inclusive cross sections  

International Nuclear Information System (INIS)

Minijet production in jet inclusive cross sections at hadron colliders, with large rapidity intervals between the tagged jets, is evaluated by using the BFKL pomeron. We describe the jet inclusive cross section for an arbitrary number of tagged jets, and show that it behaves like a system of coupled pomerons.

1992-01-01

387

The impact of multilumen infusion devices on the occurrence of known physical drug incompatibility: a controlled in vitro study.  

UK PubMed Central (United Kingdom)

BACKGROUND: Drug incompatibility is a problem, especially when managing patients in intensive care units. We designed the present study to assess the impact of multilumen infusion access devices on the occurrence of known physical drug incompatibility through a controlled in vitro study. METHODS: Three infusion devices connected to a single-lumen catheter were studied: a standard set with 2-port manifold and 1-m extension set and 2 multilumen infusion access devices: a 3-lumen extension set and a 9-lumen extension set (Edelvaiss-Multiline™; Doran International, Toussieu, France). For the 9-lumen extension set, 3 infusion access combinations were studied. Furosemide, midazolam, and saline were infused simultaneously through 3 infusion devices. Three concentrations of furosemide were tested. The infusion rate of saline (carrier) was initially set at 100 mL/h and stepwise decreased by 10 mL/h until precipitate formation. Physical incompatibility was assessed by 2 tests: visual inspection and the subvisible particle count test according to the European Pharmacopeia. The lowest saline infusion rate to prevent visible precipitate and attain an acceptable particle count (i.e., to pass "the 2 tests") was reported for each infusion set. RESULTS: The standard set revealed visible precipitate even at the highest saline flow rate (100 mL/h). The 3-lumen device prevented drug precipitation using the 2 lowest furosemide concentrations with a saline infusion rate that decreased with furosemide concentration. The 9-lumen infusion access device prevented drug precipitation whatever the furosemide concentration for 2 access combinations using saline infusion rates of between 20 and 60 mL/h but not for a third access combination, despite saline infusion rates equal to 100 mL/h. CONCLUSIONS: Infusion device characteristics appear to have an impact on the physical compatibility of the 2 drugs. Under specified conditions, the 9-lumen infusion access device prevents physical furosemide-midazolam incompatibility.

Foinard A; Décaudin B; Barthélémy C; Debaene B; Odou P

2013-01-01

388

Rate of metoclopramide infusion affects the severity and incidence of akathisia  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Objective: To investigate the effect of the rate of metoclopramide infusion on akathisia incidence, severity, onset of symptoms, and duration in patients with headache, and/or nausea/vomiting in the emergency department (ED) setting.

Parlak, I; Atilla, R; Cicek, M; Parlak, M; Erdur, B; Guryay, M; Sever, M; Karaduman, S

389

Cis platine (CDDP) in continuous intravenous ambulatory infusion: a new method of administration.  

Science.gov (United States)

Twenty-three patients with metastatic tumors received multiple chemotherapy regimens which included CIS platine (CDDP) by continuous ambulatory infusion for 4 successive days at a rate of 25 mg/m2/day repeated every 4 weeks. Continuous infusion was provided by an external disposable pump, the "Infusor," which delivers the drug in a volume of 48 ml at a constant rate of 2 ml/hour, in conjunction with oral hydration and antiemetics. No incident detrimental to the patient was recorded. The average duration of the infusions was 23 hr. Only 22% of the patients had minor nausea and vomiting, and 1 case of functional renal insufficiency (4%) was easily corrected by simple intravenous hydration. A randomized study is ongoing to compare continuous perfusion with standard infusion for efficiency, side effects and response rate. Patients with "Infusor" are treated at home under Minitel supervision. PMID:3779603

Benahmed, M; Renaux, J; Spielman, M; Rouesse, J

1986-01-01

390

Cis platine (CDDP) in continuous intravenous ambulatory infusion: a new method of administration.  

UK PubMed Central (United Kingdom)

Twenty-three patients with metastatic tumors received multiple chemotherapy regimens which included CIS platine (CDDP) by continuous ambulatory infusion for 4 successive days at a rate of 25 mg/m2/day repeated every 4 weeks. Continuous infusion was provided by an external disposable pump, the "Infusor," which delivers the drug in a volume of 48 ml at a constant rate of 2 ml/hour, in conjunction with oral hydration and antiemetics. No incident detrimental to the patient was recorded. The average duration of the infusions was 23 hr. Only 22% of the patients had minor nausea and vomiting, and 1 case of functional renal insufficiency (4%) was easily corrected by simple intravenous hydration. A randomized study is ongoing to compare continuous perfusion with standard infusion for efficiency, side effects and response rate. Patients with "Infusor" are treated at home under Minitel supervision.

Benahmed M; Renaux J; Spielman M; Rouesse J

1986-01-01

391

IPMC-assisted miniature disposable infusion pumps with embedded computer control  

Science.gov (United States)

For military applications, the availability of safe, disposable, and robust infusion pumps for intravenous fluid and drug delivery would provide a significant improvement in combat healthcare. To meet these needs, we have developed a miniature infusion prototype pump for safe and accurate fluid and drug delivery that is programmable, lightweight, and disposable. In this paper we present techniques regarding inter-digitated IPMCs and a scaleable IPMC that exhibits significantly improved force performance over the conventional IPMCs. The results of this project will be a low cost accurate infusion device that can be scaled from a disposable small volume liquid drug delivery patch to disposable large volume fluid resuscitation infusion pumps for trauma victims in both the government and private sectors of the health industry.

Vohnout, Sonia; Kim, Sang-Mun; Park, Il-Seok; Banister, Mark; Tiwari, Rashi; Kim, Kwang J.

2007-04-01

392

MECHANISMS OF ENDOTOXIN TOLERANCE : III. THE REFRACTORY STATE DURING CONTINUOUS INTRAVENOUS INFUSIONS OF ENDOTOXIN  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Bacterial endotoxins were administered by continuous intravenous infusions at constant rates to normal man and rabbits. An initial progressive febrile reaction was followed by progressive defervescence to baseline. The resulting pyrogenic refractory state was characterized as follows: (a) reticuloe...

Greisman, Sheldon E.; Woodwards, William E.

393

Herbal infusions as a source of calcium, magnesium, iron, zinc and copper in human nutrition.  

UK PubMed Central (United Kingdom)

The study material consisted of five herbs: chamomile (flowers), mint (leaves), St John's wort (flowers and leaves), sage (leaves) and nettle (leaves), sourced from three producers. The calcium, magnesium, iron, zinc and copper contents were determined for both dried herb samples and prepared infusions, and the extraction rates were calculated. Mineral components were determined using atomic absorption spectrometry. Analysis showed that the contents of i