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COMPROMISO SISTÉMICO POR LINFOMA INTRAVASCULAR DE CÉLULA GRANDE / SYSTEMIC COMPROMISE FROM LARGE CELL INTRAVASCULAR LYMPHOMA / COMPROMISSO SISTÉMICO POR LINFOMA INTRAVASCULAR DE CÉLULA GRANDE  

Scientific Electronic Library Online (English)

Full Text Available SciELO Colombia | Language: Spanish Abstract in portuguese Apresenta-se o primeiro caso de linfoma intravascular de célula grande, uma variante do linfoma de células B grandes difuso, diagnosticado no Hospital Militar Central de Bogotá, numa mulher adulta maior, quem conferiu por uma síndrome febril prolongado, perda de peso, sintomas constitucionais e quem [...] vinte dias antes do rendimento perdeu força progressiva, até a paraplegia. Iniciaram-se estudos para descartar doenças neoplásicas, infecciosas e auto-imunes, mas faleceu o dia quatorze de sua hospitalização. O estudo post-mortem, realizado cinco horas depois, mostrou uma lesão tumoral maligna de célula grande, limitada aos espaços vasculares de múltiples vísceras. Propôs-se como diagnóstico uma neoplasia de origem linfóide, que se confirmou posteriormente mediante provas inmunohistoquímicas. Abstract in spanish Se presenta el primer caso de linfoma intravascular de célula grande, una variante del linfoma de células B grandes difuso, diagnosticado en el Hospital Militar Central de Bogotá, en una mujer adulta mayor, quien consultó por un síndrome febril prolongado, pérdida de peso, síntomas constitucionales [...] y quien veinte días antes del ingreso perdió fuerza progresiva, hasta la paraplejia. Se iniciaron estudios para descartar enfermedades neoplásicas, infecciosas y autoinmunes, pero falleció el día catorce de su hospitalización. El estudio post-mortem, realizado cinco horas después, mostró una lesión tumoral maligna de célula grande, limitada a los espacios vasculares de múltiples vísceras. Se planteó como diagnóstico una neoplasia de origen linfoide, que se confirmó posteriormente mediante pruebas inmunohistoquímicas. Abstract in english This is the first case of intravascular large cell lymphoma diagnosed at the Hospital Militar de Bogota, in an adult female who presented with chronic fever, weight loss, constitutional symptoms and progressive motor deterioration for the previous 20 days to the point of paraplegia. A work up was ca [...] rried out to rule out neoplastic diseases, infections or autoimmune diseases, but she died on the fourteen hospital day. The autopsy, performed 5 hours post mortem, showed an intravascular large cell malignancy, limited to the vascular spaces of multiple organs. The lymphomatous origin was confirmed posteriorly by immunochemical tests.

JOSÉ J., ARIAS A.; LAURA, ESCOBAR; MARÍA HELENA, ASTORQUIZA.

2008-07-01

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Linfoma intravascular do pulmão: A propósito de um caso clínico com boa resposta à terapêutica / Intravascular pulmonary lymphoma with good response to treatment. A case report  

Scientific Electronic Library Online (English)

Full Text Available SciELO Portugal | Language: Portuguese Abstract in portuguese O linfoma intravascular é uma forma muito rara de linfoma não Hodgkin de células grandes B. Caracteriza-se pela proliferação celular tumoral de linfócitos limitada aos pequenos vasos, particularmente nos capilares. Apresentamos o caso de uma doente de 54 anos, não fumadora, que foi admitida no nosso [...] hospital para investigação de um quadro com quatro meses de evolução de febre, sudorese nocturna, emagrecimento não quantificado e dispneia progressiva. Ao exame objectivo apresentava-se febril, taquicárdica e polipneica. Analiticamente, destacava-se anemia, leucocitose e LDH elevada. Gasometria arterial - FiO2 1 l/m: PaO2-63,6 mm Hg. A telerradiografia de tórax revelava infiltado intersticial difuso. Foram excluídas todas as causas de febre de origem indeterminada. O diagnóstico foi realizado por biópsia pulmonar cirúrgica e foi prescrita terapêutica citostática combinada e rituximab com boa resposta clínica. Relatamos o caso pela dificuldade diagnóstica e pela boa resposta à terapêutica. Abstract in english Intravascular lymphoma is a very rare form of large B cell non-Hodgkin’s lymphoma, characterised by the presence of lymphoma cells in the lumina of small vessels only, particulary in the capillaries. We report a 54 year-old female non-smoker, admitted to hospital for further examination of a four mo [...] nth long clinical condition involving high fever, night sweats, unqualified weight loss and progressive dyspnea. Patient’s temperature was 38.5 ºC, pulse 100/min and respiratory 22 cycles/min. Patient’s haemoglobin was 9.4g/dL, she had leukocytosis, elevated LDH and arterial blood gas analysis with moderate hypoxaemia (FiO2 1l/m: PaO2-63.6 mm Hg). Chest X-ray revealed diffuse interstitial changes. All the possible causes of unknown origin fever were excluded. Diagnosis was made through lung biopsy and treatment with combined chemotherapy and rituximab was prescribed leading to a 48 hours clinical remission. We present this case to show how difficult this diagnosis can be and how a good response to therapy is possible.

M, Felizardo; A C, Mendes; A, Fernandes; P, Campos; V, Magalhães; I, Correia; A, Pignatelli; C, Ferreira; R, Sotto-Mayor; A Bugalho de, Almeida.

2008-12-01

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Primary lymphoma of the liver treated by extended hepatectomy and chemotherapy: a case report Linfoma primário do fígado tratado por hepatectomia ampliada e quimioterapia: relato de caso  

Directory of Open Access Journals (Sweden)

Full Text Available Primary lymphoma of the liver is an extremely rare entity. A case of anaplastic large B-cell (both CD-20 and lambda positive non-Hodgkin's lymphoma that was confined to the liver in a 33-year-old man is reported. The patient was treated with an extended right hepatectomy and combination chemotherapy: cyclophosphamide, adriamycin, vincristine, and prednisone. The patient was disease free 24 months after the procedure.O linfoma primário do fígado é uma entidade extremamente rara. Os autores relatam um caso de linfoma não-Hodgkin de células B grandes anaplásicas (positivo para CD-20 e Lambda em um paciente do sexo masculino de 33 anos. O tumor estava localizado no lobo hepático direito e foi tratado por hepatectomia direita ampliada e quimioterapia pós-operatória com ciclofosfamida, adriamicina, vincristina e prednisone. Vinte quatro meses de seguimento o paciente encontra-se sem recidiva tumoral.

Eleazar Chaib

2002-09-01

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Linfoma intravascular de células B grandes: hallazgos clínicos y morfológicos en un caso con desenlace fatal / Intravascular large B cell lymphoma: Report of one case  

Scientific Electronic Library Online (English)

Full Text Available SciELO Chile | Language: Spanish Abstract in spanish [...] Abstract in english Intravascular large B cell lymphoma is a rare subtype of large cell lymphoma that is characterized by the proliferation of lymphoid cells within the lumina of small blood vessels. We report a 61-year-old male presenting paresis of both lower limbs, confusion and a history of weight loss. Magnetic re [...] sonance and CAT imaging studies showed multiple images of brain and cerebellar infarctions. Twenty days after admission, the patient died and the postmortem study demonstrated a multisystem intravascular large B cell lymphoma.

Oscar, Tapia E; Paula, Jiménez P.

2012-02-01

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Linfoma de Hodgkin óseo  

Scientific Electronic Library Online (English)

Full Text Available SciELO Ury | Language: Spanish Abstract in portuguese Resumo Introdução: os linfomas ósseos são pouco freqüentes e o inicio de um linfoma de Hodgkin com compressão medular é raro e para seu diagnóstico é necessário contar com um alto índice de suspeita. Na literatura estão descritos menos de dez casos com essas características. Material e método: apres [...] enta-se o caso clínico de um paciente de sexo masculino de 37 anos que, depois de meses com dor na coluna lombar com sintomas constitucionais apresenta paraparesia de membros inferiores; a avaliação com radiografia tomografia e ressonância da coluna mostrou destruição e compressão de vértebras lombares com compromisso medular realizando-se cirurgia para estabilização da coluna. A biopsia óssea mostrou infiltrado inflamatório com fibrose não específica; o paciente foi tratado com antibióticos e posteriormente recebeu tratamento antituberculoso. Na evolução observou-se o aparecimento de conglomerados adenopáticos superficiais e profundos; a biopsia de gânglio axilar levou ao diagnóstico de linfoma de Hodgkin. Realizou-se uma revisão bibliográfica de linfoma de Hodgkin ósseo e sua apresentação com compressão de medula. Resultados: o paciente foi tratado com radioterapia e quimioterapia com evolução clínica boa, com resolução radiológica das lesões ósseas e persistência da tumoração parotídea, razão pela qual recebeu radioterapia. O compromisso ósseo no linfoma de Hodgkin não é um fator independente de mal prognóstico e não se deve extrapolar ao compromisso da medula óssea na doença avançada. Conclusão: os linfomas ósseos são pouco frequentes, porém podem começar com compromisso ósseo e com compressão medular. Muitas vezes, se não há suspeita da doença, o diagnóstico da biopsia óssea pode ser infiltrado inflamatório inespecífico com elementos de fibrose e nessa situação devemos suspeitar de linfoma ósseo. O tratamento habitual é a combinação de radioterapia e quimioterapia com bom prognóstico funcional e vital, pois o compromisso ósseo não é um fator de predição independente de mal prognóstico. Abstract in spanish Introducción: los linfomas óseos son infrecuentes y el debut del linfoma de Hodgkin como compresión medular es excepcional y requiere para su diagnóstico alto índice de sospecha. Se describen menos de diez casos en la literatura con esta presentación. Material y método: se presenta el caso clínico d [...] e un paciente de sexo masculino de 37 años que tras meses de dolor en columna lumbar con síntomas constitucionales, instala paraparesia de miembros inferiores siendo valorado con radiografía, tomografía y resonancia de columna que muestran destrucción y aplastamiento vertebral lumbar con compromiso medular, por lo cual se interviene quirúrgicamente para estabilización de columna. La biopsia ósea muestra infiltrado inflamatorio con fibrosis no específico y recibe tratamiento antibiótico y posteriormente tratamiento antituberculoso. En la evolución instala conglomerados adenopáticos superficiales y profundos, lográndose el diagnóstico de linfoma de Hodgkin a través de la biopsia de ganglio axilar. Se realiza una revisión bibliográfica del linfoma de Hodgkin óseo y su presentación como compresión medular. Resultados: el paciente recibe tratamiento combinado de radioterapia y quimioterapia con buena evolución clínica, con resolución radiológica de las lesiones óseas y persistencia de tumoración parotidea, por lo que recibe radioterapia. El compromiso óseo en el linfoma de Hodgkin no constituye un factor independiente de mal pronóstico y no debe extrapolarse al compromiso de la médula ósea en la enfermedad avanzada. Conclusión: los linfomas óseos son infrecuentes, pero la enfermedad puede debutar con el compromiso óseo y manifestarse como compresión medular. La biopsia ósea, si no se sospecha la enfermedad, muchas veces es informada como infiltrado inflamatorio inespecífico con elementos de fibrosis y es en esa situ

Marianella, Maiche; María, Piñeyrúa; Victoria, Perroni; Gabriela, Alliaume; Ruben, Martínez.

2010-03-01

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Linfoma Gástrico Primario  

Scientific Electronic Library Online (English)

Full Text Available Introducción: El Linfoma Gástrico Primario es una entidad infrecuente dentro de las neoplasias que afectan el estómago. La histología del Linfoma Gástrico Primario es variada y adquiere connotación especial el Linfoma a células B de la zona marginal extranodal, por su potencial remisión con la antib [...] ioticoterapia. Objetivos: Apreciar las características clínicas de los pacientes con Linfoma Gástrico Primario, los hallazgos endoscópicos más relevantes, identificar los factores que influencian la supervivencia y evaluar los efectos de la terapia. Material y métodos: El presente estudio es de tipo observacional, analítico y de corte transversal, se realizó en 169 pacientes con diagnóstico histológico de Linfoma Gástrico que fueron atendidos en el Instituto Especializado de Enfermedades Neoplásicas, Lima-Perú, desde Enero de 1995 a Diciembre del 2000. Para el estadiaje se utilizó el sistema Ann Arbor modificado por Musshoff y la histología de acuerdo a la clasificación REAL-WHO. El análisis estadístico incluyó el t de student y el chi cuadrado. La supervivencia fue consignada con las curvas de Kaplan Meier y los factores pronóstico con el test de regresión de Cox. Resultados: La muestra es representativa de pacientes de la Costa Peruana. La edad promedio es 55 años, con discreta predominancia del sexo femenino (54.4%). Los signos y síntomas son inespecíficos. El estadio clínico I-II corresponde al 75% de los pacientes. El patrón endoscópico de lesiones ulceradas múltiples es característico del Linfoma Gástrico. El 71% de los pacientes con Linfoma a células B de la zona marginal extranodal tuvieron remisión completa de la enfermedad con antibióticoterapia (5/7). El tipo histológico del Linfoma Gástrico en los 169 pacientes fue el siguiente: Linfoma a células B grande difuso 137 pacientes, Linfoma a células B de la zona marginal extra nodal 16 pacientes, Linfoma a células T periférico 6 pacientes, Linfoma a células grandes T anaplásico 3 pacientes, Linfoma no determinado 3 pacientes, Linfoma a células del manto 2 pacientes, Linfoma a células T del adulto 1 paciente y Linfoma folicular 1 paciente. La sobrevida global a 36 meses fue de 61.34%, la supervivencia de acuerdo al tipo histológico fue del 92.31% para Los Linfomas a células B de la zona marginal extranodal, del 62.21% para los Linfomas a células B grande difuso y del 29.63% para los Linfomas a células T. La sobrevida a 36 meses en pacientes con estadio clínico I-II que fueron tratados con quimioterapia fue del 82.16%, con cirugía fue del 71.89% y con cirugía más quimioterapia fue del 70.39%, mostrando los 3 grupos resultados semejantes (p: 0.6530). Los grupos catalogados de acuerdo al índice internacional, mostraron una clara diferencia entre ellos (p: 0.0000). El análisis univariado reveló que el Zubrod (p: 0.0000), el DHL (p: 0.0073), la remisión de la enfermedad (p: 0.0000), el estadio (p: 0.0000), el tratamiento (p: 0.0000), y la localización (p: 0.0000), tuvieron significancia estadística. El análisis multivariado mostró que en el modelo de regresión de Cox, la remisión (OR: 13.342, p: 0.0000), y la localización (OR: 2.375, p: 0.041), se encuentran dentro de la ecuación de dicha función. Conclusiones: Las lesiones ulceradas múltiples son características del Linfoma Gástrico. Se demuestra remisión de enfermedad en el Linfoma a células B de la zona marginal extranodal con antibioticoterapia (5/7). La quimioterapia en pacientes con EC I-II, alcanza resultados de supervivencia semejantes a la cirugía y a la combinación de ambas. Se confirma la validez del índice internacional y se demuestra en el análisis multivariado que la remisión y la localización de la enfermedad tienen significancia estadística. Abstract in english Introduction: Primary Gastric Lymphoma is an uncommon malignancy among gastric malignancies. Histology of the Primary Gastric Lymphoma is varied and the extranodal marginal zone B-cells lymphoma is specially significant on account of its potent

Fernando, Barreda B; Regina, Gómez P; Dolly, Quispe L; Juvenal, Sánchez L; Juan, Combe G; Luis, Casanova M; Juan, Celis Z.

2004-07-01

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Advanced Hodgkin's lymphoma: results in 216 patients treated with ABVD in Brazil / Linfoma de Hodgkin em estádio avançado: resultados do tratamento em 216 pacientes tratados com ABVD no Brasil  

Scientific Electronic Library Online (English)

Full Text Available Os resultados do tratamento do linfoma de Hodgkin (LH) melhoraram substancialmente ao longo das últimas décadas e tornaram o LH uma das neoplasias humanas com maior chance de cura. Entretanto, os dados sobre tratamento em países em desenvolvimento são escassos. Entre 1996 e 2005, 370 pacientes conse [...] cutivos com LH tratados em três instituições públicas no Rio de Janeiro foram identificados. Destes, 216 em estádio avançado (IIB-IV) foram selecionados para esta análise. Os pacientes foram tratados com o protocolo ABVD (doxorrubicina, bleomicina, vinblastina e dacarbazina). A mediana do tempo de seguimento dos sobreviventes foi de 6,3 anos (1-11,8). Quinze pacientes morreram durante o tratamento de primeira linha. A probabilidade de sobrevida livre de progressão (SLP) em cinco anos e a probabilidade de sobrevida global (SG) em cinco anos foram de 69% e 83%, respectivamente. A SLP nos grupos de baixo risco e de alto risco, de acordo com o "International Prognostic Score", foi de 81% e 62% (p=0,003), respectivamente. A SG em cinco anos nos grupos de baixo risco e de alto risco foi de 89% e 78% (p=0,02), respectivamente. O presente estudo apresenta uma estimativa representativa dos resultados atuais do tratamento do LH avançado em instituições públicas no Brasil. Fica claro que o tratamento completo pode ser oferecido à grande maioria dos pacientes, embora aqueles com baixo status socioeconômico possam exigir atenção especial. Em vista das dimensões continentais do Brasil, com substancial heterogeneidade interregional, um registro nacional de pacientes com LH está sendo implementado. Abstract in english The outcome of Hodgkin's lymphoma (HL) has markedly improved over the last few decades, placing HL among the human cancers with highest cure rates. However, data about treatment outcomes in developing countries are scarce. From 1996 to 2005, 370 consecutive patients with HL treated in three public i [...] nstitutions in Rio de Janeiro were identified. A total of 216 patients who presented with advanced stage (IIB-IV) HL were selected for the present analysis. Patients with advanced disease were treated with ABVD, complemented or not by radiation therapy. The median follow-up time of survivors was 6.3 years (1-11.8). Fifteen patients died during first-line treatment. The complete remission rate was 80%. The 5-year progression-free survival (PFS) and the 5-year overall survival (OS) probabilities were 69% and 83%, respectively. The 5-year PFS in low-risk and high-risk patients were 81% and 62% (p=0.003), respectively. The 5-year OS in low-risk and high-risk International Prognostic Score patients were 89% and 78% (p=0.02), respectively. The present study provides a representative estimate of current treatment results for advanced HL in public institutions in an urban area in Brazil. It is clear that full treatment can be given to most patients, although those with very low socio-economic status might require special attention and support. Since Brazil is a large country, with substantial interregional heterogeneity, a nationwide registry of HL patients is currently being implemented.

Luciana, Britto; Irene, Biasoli; Denize, Azambuja; Adriana, Scheliga; Andrea, Soares; Munya, Gandour; Tatiana, Hofmeister; Thiago, Vieites; Cristiane, Milito; Wolmar, Pulcheri; José Carlos, Morais; Nelson, Spector.

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Advanced Hodgkin's lymphoma: results in 216 patients treated with ABVD in Brazil Linfoma de Hodgkin em estádio avançado: resultados do tratamento em 216 pacientes tratados com ABVD no Brasil  

Directory of Open Access Journals (Sweden)

Full Text Available The outcome of Hodgkin's lymphoma (HL has markedly improved over the last few decades, placing HL among the human cancers with highest cure rates. However, data about treatment outcomes in developing countries are scarce. From 1996 to 2005, 370 consecutive patients with HL treated in three public institutions in Rio de Janeiro were identified. A total of 216 patients who presented with advanced stage (IIB-IV HL were selected for the present analysis. Patients with advanced disease were treated with ABVD, complemented or not by radiation therapy. The median follow-up time of survivors was 6.3 years (1-11.8. Fifteen patients died during first-line treatment. The complete remission rate was 80%. The 5-year progression-free survival (PFS and the 5-year overall survival (OS probabilities were 69% and 83%, respectively. The 5-year PFS in low-risk and high-risk patients were 81% and 62% (p=0.003, respectively. The 5-year OS in low-risk and high-risk International Prognostic Score patients were 89% and 78% (p=0.02, respectively. The present study provides a representative estimate of current treatment results for advanced HL in public institutions in an urban area in Brazil. It is clear that full treatment can be given to most patients, although those with very low socio-economic status might require special attention and support. Since Brazil is a large country, with substantial interregional heterogeneity, a nationwide registry of HL patients is currently being implemented.Os resultados do tratamento do linfoma de Hodgkin (LH melhoraram substancialmente ao longo das últimas décadas e tornaram o LH uma das neoplasias humanas com maior chance de cura. Entretanto, os dados sobre tratamento em países em desenvolvimento são escassos. Entre 1996 e 2005, 370 pacientes consecutivos com LH tratados em três instituições públicas no Rio de Janeiro foram identificados. Destes, 216 em estádio avançado (IIB-IV foram selecionados para esta análise. Os pacientes foram tratados com o protocolo ABVD (doxorrubicina, bleomicina, vinblastina e dacarbazina. A mediana do tempo de seguimento dos sobreviventes foi de 6,3 anos (1-11,8. Quinze pacientes morreram durante o tratamento de primeira linha. A probabilidade de sobrevida livre de progressão (SLP em cinco anos e a probabilidade de sobrevida global (SG em cinco anos foram de 69% e 83%, respectivamente. A SLP nos grupos de baixo risco e de alto risco, de acordo com o "International Prognostic Score", foi de 81% e 62% (p=0,003, respectivamente. A SG em cinco anos nos grupos de baixo risco e de alto risco foi de 89% e 78% (p=0,02, respectivamente. O presente estudo apresenta uma estimativa representativa dos resultados atuais do tratamento do LH avançado em instituições públicas no Brasil. Fica claro que o tratamento completo pode ser oferecido à grande maioria dos pacientes, embora aqueles com baixo status socioeconômico possam exigir atenção especial. Em vista das dimensões continentais do Brasil, com substancial heterogeneidade interregional, um registro nacional de pacientes com LH está sendo implementado.

Luciana Britto

2010-01-01

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Linfoma renal primario / Primary renal lymphoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish OBJETIVO: Presentar un caso de linfoma renal primario. MATERIAL Y MÉTODOS: Estudiamos el caso clínico de un paciente en el que se descubrió una masa renal, con el diagnóstico anatomopatológico de linfoma renal primario. RESULTADOS: Se trata de un paciente de 78 años de edad que acudió a nuestra cons [...] ulta por dolor en fosa renal derecha. Al realizar varias pruebas complementarias se llegó al diagnóstico de masa renal derecha, cuyo estudio anatomopatológico tras punción-biopsia reveló un linfoma difuso de células B, siendo tratado con ciclos de quimioterapia sistémica según la pauta CHOP. CONCLUSIONES: El linfoma renal primario es una entidad rara y cuestionada por muchos autores. En la práctica clínica se presenta de modo similar al resto de tumores renales, por lo que su diagnóstico debe ser histológico. El tratamiento de elección es la quimioterapia sistémica con la combinación CHOP. Abstract in english OBJECTIVE: To describe a case of primary renal lymphoma. MATERIAL AND METHODS: We presents a patient with a right renal mass which histological analysis revealed a non-Hodgkin Lymphoma. RESULTS: A 78-year-old male patient with right flank pain mass was referred to our Service. He was diagnosed of re [...] nal mass by imaging studies. Inmunohistochemical investigations revealed a B-cell-type lymphoma. He received combination chemotherapy with CHOP. CONCLUSIONS: Primary renal lymphoma is a rare disease whose existence has been questioned, because the kidney does not normally contain lymphoid tissue. Its clinical presentation is like any other renal tumor and its definitive diagnosis is by histology. Elective treatment is chemotherapy (CHOP).

J.R., Torrecilla García-Ripoll; M., Pascual Samaniego; S., Martín Blanco; J., Rivera Ferro; J.I., Peral Martínez; E., Fernández del Busto.

2003-08-01

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Tratamiento del linfoma cutáneo de células T con bexaroteno a dosis bajas en combinación con fototerapia o interferon alfa: comunicación de ocho casos tratados en el Hospital Edgardo Rebagliati Martins, 2003-2007, Lima, Perú / Therapy for cutaneous T-cell lymphoma using low-dose bexarotene combined with phototherapy or alpha-interferon: Report of eight cases treated in Hospital Nacional Edgardo Rebagliati-Martins, Lima, Peru between 2003 and 2007  

Scientific Electronic Library Online (English)

Full Text Available Introducción: bexaroteno es un rexinoide aprobado en el tratamiento de estadios tempranos y avanzados del linfoma cutáneo de células T (LCCT). Caso Clínico: el presente reporte de casos mostramos los resultados del empleo de bexaroteno en dosis bajas más fototerapia o Interferon alfa 9 millones en e [...] l tratamiento del LCCT. Ocho pacientes fueron tratados, cinco fueron Micosis fungoides, dos Linfoma Epidermotrópico CD8 agresivo y uno fue un Síndrome Sézary. La respuesta global fue del 62.5% (5/8) y la duración media de respuesta fue de 20 meses. El bexaroteno en dosis bajas en combinación a fototerapia o interferon alfa 2a puede ser efectivo en el tratamiento del LCCT. Abstract in english Introduction: Bexarotene is a rexinoid compound that is approved for use in the therapy for early and advanced stage cutaneous T-cell lymphoma (CTCL). Clinical Cases: We present in this report the results of the use of low-dose bexarotene plus phototherapy or alpha-interferon, nine million units, in [...] the treatment of CTCL. Eight patients were treated, five had mycosis fungoides, two had CD-8 epidermothropic aggressive lymphoma. The overall response rate was 62.5% (5/8), and the mean duration of response was 20 months. Low-dose bexarotene combined with phototherapy or alpha-interferon may be effective in the treatment of CTCL.

Brady, Beltrán Gárate; Antonio, Paredes Arcos; Celia, Moisés Alfaro; Gadwin, Sanchez Félix; Luis, Riva Gonzales; Fernando, Hurtado de Mendoza; Esther, Cotrina Montenegro; Renzo, Rojas.

2008-10-01

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Intravascular ultrasound  

Science.gov (United States)

IVUS; Ultrasound - coronary artery; Endovascular ultrasound; Intravascular echocardiography ... A tiny ultrasound wand is attached to the top of a thin tube called a catheter. This ultrasound catheter is inserted ...

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Tumor intracardíaco como presentación de leiomiomatosis intravascular / Intracardiac tumor as presentation of Intravascular leiomyomatosis  

Scientific Electronic Library Online (English)

Full Text Available SciELO Chile | Language: Spanish Abstract in spanish Presentamos un caso de leiomiomatosis intravascular que se extiende a cavidades cardiacas derechas, siendo tratado mediante cirugía en un tiempo. [...] Abstract in english We present a case of an intravenous leiomyomatosis extending into the right cardiac chambers, which was treated by one stage surgery. [...

Javier, Labbé; Andrés, Pumarino; Gerardo, Valdivia; Julio, Ibarra; Lorenzo, Merello; Manuel, Quiroz.

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Disseminated intravascular coagulation (DIC)  

Science.gov (United States)

Disseminated intravascular coagulation (DIC) is a serious disorder in which the proteins that control blood clotting become over ... Levi M. Disseminated intravascular coagulation. In: Hoffman R, ... LE, et al., eds. Hematology: Basic Principles and Practice . 6th ...

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Disseminated Intravascular Coagulation  

Science.gov (United States)

... page from the NHLBI on Twitter. What Is Disseminated Intravascular Coagulation? Disseminated intravascular coagulation (ko-ag-u-LA-shun), or DIC, is ... condition. Rate This Content: NEXT >> November 2, 2011 Disseminated Intravascular Coagulation Clinical Trials Clinical trials are research studies that ...

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Linfoma não Hodgkin gástrico Gastric non-Hodgkin Lymphoma  

OpenAIRE

Os linfomas extralinfonodais representam aproximadamente 1/3 de todos os linfomas não Hodgkin (LNH) e, embora possam ter início em qualquer tecido, mais frequentemente acometem o trato gastrointestinal, sendo o estômago o órgão responsável pela grande maioria dos casos. Os linfomas primários gástricos são comumente LNH, sendo representados em mais de 95% dos casos pelo linfoma difuso de grandes células B e pelo linfoma MALT (mucosa associated lymphoid tissue). De evolução indolent...

Costa, Renata O.; Hallack Neto, Abraha?o E.; Chamone, Dalton A. F.; Vera Lúcia Aldred; Pracchia, Luis F.; Juliana Pereira

2010-01-01

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Primary Non-Hodgkins lymphoma of the parotid gland Linfomas malignos primários nas glandulas salivares  

Directory of Open Access Journals (Sweden)

Full Text Available Primary malignant lymphomas in the salivary glands are relatively rare. Clinical presentation is not characteristic and the disease is often overlooked resulting in diagnosis and treatment delays. AIM: To stress the importance of the diagnostic process and combined management, we present a series of eight patients with malignant lymphoma of the parotid who were diagnosed only after surgery and managed with radiation and chemotherapy. METHODS: Retrospective series of patients with primary malignant lymphoma of the parotid gland managed with radiotherapy and diagnostic surgical partial resection. RESULTS: After treatment completion we achieved a loco-regional control rate of 87.5%. Toxicity was charted according to the Common Toxicity Criteria and it was seen in six patients (75%. Six patients are still alive without evidence of recurrent disease in their last follow-up. CONCLUSION: Our study confirms that primary early stage Non-Hodgkin Lymphoma of the parotid gland is a disease with an excellent prognosis and a good local control rate, with minimal morbidity.Linfomas primários das glândulas salivares são relativamente raros. Sua apresentação clínica não écaracterística e, frequentemente, a doença passa despercebida, resultando em atrasos no diagnóstico e tratamento. OBJETIVO: Enfatizar a importância do diagnóstico e tratamento combinado. Apresentamos uma casuística de oito pacientes com linfoma maligno da parótida, que foram diagnosticados somente após a cirurgia e tratados com radio e quimioterapia. MÉTODOS: Estudo retrospectivo de pacientes com linfoma maligno primário da glândula parótida, tratados com radioterapia e ressecção cirúrgica parcial diagnóstica. RESULTADOS: Após a conclusão do tratamento, atingimos uma taxa de controle loco-regional de 87,5%. A toxicidade foi classificada de acordo com os Critérios Comuns de Toxicidade e afetou seis pacientes (75%. Seis pacientes ainda estão vivos, sem evidência de doença na mais recente consulta de acompanhamento. CONCLUSÃO: Nosso estudo confirma que o Linfoma primário Não-Hodgkin em estágios iniciais da glândula parótida é uma doença com excelente prognóstico e boa taxa de controle local, com mínima morbidade.

Francesco Dispenza

2011-10-01

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Linfoma primario de pulmón: Serie de casos / Primary pulmonary lymphoma: A case serie  

Scientific Electronic Library Online (English)

Full Text Available Los linfomas primarios de pulmón (LPP) son infrecuentes. Sus manifestaciones clínicas y las imágenes son inespecíficas. El retraso diagnóstico puede ser considerable. Objetivo: Analizar los LPP durante el período 2003-2013 en nuestra institución. Sobre 1892 linfomas, 4 fueron LPP (0,21%): 1) linfoma [...] no Hodgkin (n = 2); 2) linfoma Hodgkin (n= 1); 3) linfoma intravascular pulmonar (n = 1). Las manifestaciones clínicas y radiológicas fueron inespecíficas (masa pulmonar y derrame pleural, consolidación con broncograma aéreo y cavitación o bien ausencia de lesiones). Los métodos diagnósticos fueron: 1) punción guiada bajo TAC; 2) videotoracoscopía (VATS) y 3) VATS orientada por PET (tomografia por emisión de positrones) y 4) toracotomía. El tiempo entre la consulta inicial hasta el diagnóstico fue de 45 a 90 días. Este reporte confirma la baja incidencia de LPP, y sus manifestaciones clínicas y radiologías poco específicas. Esto puede contribuir a las demoras en el diagnóstico. El PETpuede mejorar el rendimiento diagnóstico, en especial en ausencia de compromiso pulmonar radiológico evidente. Abstract in english Primary Pulmonary Lymphomas (LPP) are infrequent and their clinical manifestations and images are usually nonspecific. Diagnostic delay may be important. The objective of this study was to analyze the LLP in our institution. Between 2003 and 2013, over 1,892 lymphomas were analyzed in our institutio [...] n. Only 4 of them (0.21% incidence) were detected as LPP: Non Hodgkin's Lymphoma (n = 2), Hodgkin's Lymphoma (n = 1), and Intravascular Pulmonary Lymphoma (n = 1). Clinical manifestations of the 4 cases presented were unspecific: 1) pulmonary mass and pleural effusion; 2) consolidation with air bronchogram and cavitations; 3) normal images and 4) pulmonary mass. Given these clinical settings, 4 diagnostic methods were used: 1) Computed Tomography-Guided Puncture, 2) Video-Assisted Thoracoscopic Surgery (VATS); 3) VATS guided by positron emission tomography (PET) and 4) thoracotomy. Hence, diagnosis was successfully made between 45 to 90 days from the initial consultation. This report confirms the low incidence of LPP, and its unspecific clinical and radiographic manifestations that may cause delay in diagnosis. PET can contribute to improve diagnostic performance, especially in patients without apparent lung involvement.

JULIO C, VILLARROEL S; MÁXIMO, ROMANCZUK; ESTEBAN J, WAINSTEIN; MARCOS, LAS HERAS; EDUARDO L, DE VITO; GRACIELA, SVETLIZA; JUAN A, PRECERUTTI.

2014-03-01

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Linfoma de ovario Ovarian lymphoma  

Directory of Open Access Journals (Sweden)

Full Text Available Introducción: el 50 % de la patología oncológica en pediatría corresponde a masas o tumores sólidos, alrededor del 20 % del total se ubica en abdomen. Los tumores que se presentan con mayor frecuencia en el abdomen son el nefroblastoma o tumor de Wilms, el linfoma tipo Burkitt, el neuroblastoma y los tumores germinales de ovario. Objetivo: presentar un caso pediátrico con tumor abdominal. Caso clínico: se presenta un caso de una niña de 8 años de edad con antecedentes de salud aparente, atendida en el Hospital Público de la Universidad de Mbarara, Uganda. Resultado: paciente pediátrica que fue ingresada con una historia de 3 meses de dolor abdominal, pérdida ligera de peso y masa abdominal de crecimiento rápido, fue sometida a una laparotomía exploradora donde se resecó la masa tumoral, la que histológicamente arrojó ser un linfoma ovárico, como hallazgo durante la intervención quirúrgica se diagnosticó una agenesia de útero. Conclusión: la paciente se encuentra después del tratamiento con quimioterapia en seguimiento, lleva aparentemente hace 5 meses una vida normal (noviembre 2011.Introduction: 50 % of pediatric oncologic pathology corresponds to mass or solid tumors, reaching about 20 % of total abdomen. The tumors that most frequently occur in the abdomen are nephroblastoma or Wilms tumor, Burkitt's lymphoma, neuroblastoma, and ovarian germ cell tumors. Objective: to present a pediatric case with abdominal tumor. Case report: we report a case of an 8 year old girl with a history of apparent good health. This patient was assisted the Public Hospital of Mbarara University, Uganda. Result: a female pediatric patient was admitted with a 3-month history of abdominal pain, mild weight loss, and rapid growth of an abdominal mass. This patient underwent an exploratory laparotomy where the tumor mass was removed. It was histologically confirmed as an ovarian lymphoma. It was diagnosed uterus agenesis. Conclusion: after chemotherapy, the patient is controlled, and she has an apparently normal life for already 5 months (November 2011.

Iván Bonet Fonseca

2012-09-01

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Linfoma de Hodgkin con afectación ósea: comunicación de un caso y revisión de la literatura  

Scientific Electronic Library Online (English)

Full Text Available Existen pocas comunicaciones en la literatura acerca de la afectación ósea primaria por linfoma de Hodgkin. El linfoma de Hodgkin representa menos del 0'15% de los tumores malignos primarios del hueso, aunque por radiología es frecuente detectar lesiones óseas en pacientes con enfermedad de Hodgkin. [...] Comunicamos el caso de un paciente inicialmente diagnosticado de linfoma de Hodgkin en fémur izquierdo, tratado con un régimen combinado de quimioradioterapia secuencial, que permanece libre de recaída a cuatro años después, aprovechando para revisar la literatura respecto a su diagnóstico y tratamiento. Abstract in english There are few literature reports about bone primary Hodgkin's lymphoma. Hodgkin's lymphoma represents less than 0.15 % of the primary malignant bone tumors, although radiology studies frequently detect bone lesions in patients with Hodgkin's disease. We report the case of a patient that was initiall [...] y diagnosed of bone Hodgkin's lymphoma with left femur involvement. The patient was treated by a combined regime of sequential chemo-radiotherapy in our Oncology Unit. He remains relapse-free three years after diagnosis. Taking advantage of our report we reviewed the literature looking for diagnostic and treatment strategies for the process.

D., Márquez Medina; B., Márquez Lobo; M. C., Talavera Hernández; I., Blancas López-Barajas; I., Sáez Medina; J. L., García Puche.

2004-03-01

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Linfoma de ovario / Ovarian lymphoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Introducción: el 50 % de la patología oncológica en pediatría corresponde a masas o tumores sólidos, alrededor del 20 % del total se ubica en abdomen. Los tumores que se presentan con mayor frecuencia en el abdomen son el nefroblastoma o tumor de Wilms, el linfoma tipo Burkitt, el neuroblastoma y lo [...] s tumores germinales de ovario. Objetivo: presentar un caso pediátrico con tumor abdominal. Caso clínico: se presenta un caso de una niña de 8 años de edad con antecedentes de salud aparente, atendida en el Hospital Público de la Universidad de Mbarara, Uganda. Resultado: paciente pediátrica que fue ingresada con una historia de 3 meses de dolor abdominal, pérdida ligera de peso y masa abdominal de crecimiento rápido, fue sometida a una laparotomía exploradora donde se resecó la masa tumoral, la que histológicamente arrojó ser un linfoma ovárico, como hallazgo durante la intervención quirúrgica se diagnosticó una agenesia de útero. Conclusión: la paciente se encuentra después del tratamiento con quimioterapia en seguimiento, lleva aparentemente hace 5 meses una vida normal (noviembre 2011). Abstract in english Introduction: 50 % of pediatric oncologic pathology corresponds to mass or solid tumors, reaching about 20 % of total abdomen. The tumors that most frequently occur in the abdomen are nephroblastoma or Wilms tumor, Burkitt's lymphoma, neuroblastoma, and ovarian germ cell tumors. Objective: to presen [...] t a pediatric case with abdominal tumor. Case report: we report a case of an 8 year old girl with a history of apparent good health. This patient was assisted the Public Hospital of Mbarara University, Uganda. Result: a female pediatric patient was admitted with a 3-month history of abdominal pain, mild weight loss, and rapid growth of an abdominal mass. This patient underwent an exploratory laparotomy where the tumor mass was removed. It was histologically confirmed as an ovarian lymphoma. It was diagnosed uterus agenesis. Conclusion: after chemotherapy, the patient is controlled, and she has an apparently normal life for already 5 months (November 2011).

Iván, Bonet Fonseca; Amnia, Díaz Anaya; Tabu, Francis; Yarine Leonell, Fajardo Tornés.

2012-09-01

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Intravascular pulmonary metastases  

International Nuclear Information System (INIS)

The diagnosis of intravascular metastatic tumor emboli to the lungs is rarely made. The authors present a characteristic radiographic finding of intravascular lung metastases that they observed in four patients with diagnoses or right atrial myoxoma, invasive renal cell carcinoma, invasive pelvic osteosarcoma, and recurrent pelvic chondrosarcoma. Substantiation of intravascular pulmonary metastases was achieved by means of autopsy, pulmonary artery biopsy, and surgical documentation of tumor invasion of the inferior vena cava or pelvic veins. In all four cases, chest computed tomography (CT) demonstrated branching, beaded opacities extending from the hila into the periphery of the lung in the distribution of pulmonary arteries. In one case, similar findings were observed in magnetic resonance (MR) images of the chest. Follow-up studies in three cases showed progressive enlargement and varicosity of the abnormal pulmonary artery consistent with proliferation of intravascular tumor. In the case of metastatic osteosarcoma, intraluminal ossification was also observed at CT. In three of four cases, pulmonary infarction was demonstrated in the distribution of the abnormal pulmonary arteries seen at CT as small, peripheral, wedge-shaped opacities. The demonstration of progressively dilated and beaded pulmonary arteries in patients with extrathoracic malignancies is suggestive of intravascular lung metastases, particularly when accompanied by peripheral infarctionanied by peripheral infarction

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Linfoma de Hodgkin na infância e adolescência: 15 anos de experiência com o protocolo DH-II-90 Hodgkin's lymphoma in children and adolescents: 15 years of experience with the DH-II-90 protocol  

OpenAIRE

O desafio do tratamento do linfoma de Hodgkin na infância reside na redução da toxicidade aguda e tardia sem afetar os bons resultados terapêuticos. Crianças e adolescentes portadores de linfoma de Hodgkin recém-diagnosticado foram tratados com o protocolo institucional DH-II-90. Os objetivo deste trabalho foram: 1)avaliar as taxas de sobrevida global (SG) e livre de eventos (SLE) do protocolo DH-II-90 aplicado a portadores de LH; 2)avaliar as taxas de SG e SLE conforme estádio, idade,...

Souza, Luciana N. S.; Maluf Junior, Paulo T.; Almeida, Maria Tereza A.; Eduardo Weltman; Ana Lucia Cornacchioni; Teixeira, Roberto Augusto P.; Vicente Odone Filho; Lilian Maria Cristofani

2010-01-01

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Linfoma no Hodgkin primario de vagina  

Scientific Electronic Library Online (English)

Full Text Available SciELO Chile | Language: Spanish Abstract in spanish La afectación primaria del tracto genital femenino de los linfomas no Hodgkin es poco frecuente (2% de los linfomas primarios extraganglionares). Los órganos más afectados son los ovarios seguidos del cérvix, siendo la localización endometrial y vaginal extremadamente rara. Presentamos el caso de un [...] a paciente de 44 años diagnosticada de linfoma primario de vagina, estadio IE A, con remisión completa tras tratamiento combinado quimioterápico y quirúrgico. Es importante tener presente estas raras aunque posibles localizaciones de linfomas para evitar que se puedan confundir con lesiones inflamatorias u otros tipos de tumores que nos lleven a un fracaso terapéutico. Abstract in english Primary non-Hodgkin lymphomas rarely involve the female genital tract (2% of primary extranodal lym-phomas). The ovaries followed by the cervix are the most common affected sites while the involvement of the endometrium and vagina is extremely rare. We report the case of a 44 year old woman with a p [...] rimary lymphoma of the vagina, stage IE A, with complete remission after combined chemotherapy and surgical treatment. These rare but possible locations must be kept in mind to avoid misdiagnosis with inflammatory lesions or other types of tumors which may lead us to a therapeutic failure.

Eva María, Guldrís N; María Pía, Vázquez C; Elba, Carballo N; Magdalena, Porto Q; Luis, Heliodoro Alba O; Begoña, Iglesias R.

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Primary Non-Hodgkins lymphoma of the parotid gland / Linfomas malignos primários nas glandulas salivares  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Languages: English, Portuguese Abstract in portuguese Linfomas primários das glândulas salivares são relativamente raros. Sua apresentação clínica não écaracterística e, frequentemente, a doença passa despercebida, resultando em atrasos no diagnóstico e tratamento. OBJETIVO: Enfatizar a importância do diagnóstico e tratamento combinado. Apresentamos um [...] a casuística de oito pacientes com linfoma maligno da parótida, que foram diagnosticados somente após a cirurgia e tratados com radio e quimioterapia. MÉTODOS: Estudo retrospectivo de pacientes com linfoma maligno primário da glândula parótida, tratados com radioterapia e ressecção cirúrgica parcial diagnóstica. RESULTADOS: Após a conclusão do tratamento, atingimos uma taxa de controle loco-regional de 87,5%. A toxicidade foi classificada de acordo com os Critérios Comuns de Toxicidade e afetou seis pacientes (75%). Seis pacientes ainda estão vivos, sem evidência de doença na mais recente consulta de acompanhamento. CONCLUSÃO: Nosso estudo confirma que o Linfoma primário Não-Hodgkin em estágios iniciais da glândula parótida é uma doença com excelente prognóstico e boa taxa de controle local, com mínima morbidade. Abstract in english Primary malignant lymphomas in the salivary glands are relatively rare. Clinical presentation is not characteristic and the disease is often overlooked resulting in diagnosis and treatment delays. AIM: To stress the importance of the diagnostic process and combined management, we present a series of [...] eight patients with malignant lymphoma of the parotid who were diagnosed only after surgery and managed with radiation and chemotherapy. METHODS: Retrospective series of patients with primary malignant lymphoma of the parotid gland managed with radiotherapy and diagnostic surgical partial resection. RESULTS: After treatment completion we achieved a loco-regional control rate of 87.5%. Toxicity was charted according to the Common Toxicity Criteria and it was seen in six patients (75%). Six patients are still alive without evidence of recurrent disease in their last follow-up. CONCLUSION: Our study confirms that primary early stage Non-Hodgkin Lymphoma of the parotid gland is a disease with an excellent prognosis and a good local control rate, with minimal morbidity.

Francesco, Dispenza; Giuseppe, Cicero; Gianluca, Mortellaro; Donatella, Marchese; Gautham, Kulamarva; Carlo, Dispenza.

2011-10-01

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Linfoma hepático primario: Evolución favorable con quimioterapia combinada con rituximab / Primary hepatic lymphoma: favorable outcome with chemotherapy plus rituximab  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish Comunicamos el caso de una paciente con un linfoma hepático primario tratado con éxito con quimioterapia combinada con rituximab. Utilizando los "encabezamientos estándar para búsquedas bibliográficas informatizadas" (Medical Subject Heading) revisamos los casos publicados hasta la fecha de esta inf [...] recuente entidad. Abstract in english This article describes the case of a patient with a non-Hodgkin primary hepatic lymphoma who was successfully treated with chemotherapy combined with rituximab. Using the Medical Subject Headings the published reports of this rare entity were reviewed. [...

I., Serrano-Navarro; J. F., Rodríguez-López; R., Navas-Espejo; M. A., Pérez-Jacoiste; M. A., Martínez-González; C., Grande; S., Prieto.

2008-11-01

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Linfoma hepático primario: Evolución favorable con quimioterapia combinada con rituximab Primary hepatic lymphoma: favorable outcome with chemotherapy plus rituximab  

Directory of Open Access Journals (Sweden)

Full Text Available Comunicamos el caso de una paciente con un linfoma hepático primario tratado con éxito con quimioterapia combinada con rituximab. Utilizando los "encabezamientos estándar para búsquedas bibliográficas informatizadas" (Medical Subject Heading revisamos los casos publicados hasta la fecha de esta infrecuente entidad.This article describes the case of a patient with a non-Hodgkin primary hepatic lymphoma who was successfully treated with chemotherapy combined with rituximab. Using the Medical Subject Headings the published reports of this rare entity were reviewed.

I. Serrano-Navarro

2008-11-01

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Linfoma de celulas B de la zona marginal extraganglionar del tejido linfoide asociado a mucosa (linfoma MALT) de pulmón  

OpenAIRE

Los Linfomas Pulmonares Primarios son extremadamente raros (0,4% de los linfomas extraganglionares), y generalmente son de tejido linfoide asociado a mucosas (tipo MALT), con ocasionales linfomas de células grandes difusos. Los síntomas son inespecíficos, y casi la mitad de los pacientes son asintomáticos. Se presenta el caso de un paciente masculino de 56 años de edad, quien presentó durante 7 meses accesos diarios de tos seca, de predominio nocturno, asociados en el último mes a fieb...

Carlos Vergara-Uzcategui; Melizabeth Ruiz

2014-01-01

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Coagulación intravascular diseminada / Disseminated intravascular coagulation  

Scientific Electronic Library Online (English)

Full Text Available La coagulación intravascular diseminada (CID) es una entidad clínica frecuente que se presenta como fenómeno secundario a diversas enfermedades entre las cuales se destacan las infecciones graves, las neoplasias y las catástrofes obstétricas. Se caracteriza por una activación difusa y simultánea de [...] los sistemas endógenos de la coagulación y la fibrinólisis. El depósito de pequeños trombos en la circulación conduce finalmente a disfunción orgánica múltiple y en algunos casos a la muerte. Las manifestaciones clínicas pueden incluir fenómenos trombóticos y hemorrágicos. Se ha propuesto un puntaje de fácil aplicación para simplificar el diagnóstico de la entidad. El tratamiento incluye el control específico de la causa subyacente que favorece la aparición de la CID, el soporte con hemoderivados en pacientes con manifestaciones de sangrado y la anticoagulación terapéutica en pacientes con trombosis mayores. El desarrollo de CID es un factor pronóstico adverso que aumenta significativamente la tasa de mortalidad. En este artículo de revisión se incluyen los siguientes aspectos de la CID: historia, epidemiología, clasificación, entidades asociadas, fisiopatología, clínica, diagnóstico, tratamiento y pronóstico. Abstract in english Disseminated intravascular coagulation (DIC) is a frequent clinical entity that presents as a secondary phenomenon associated with some diseases, including, among others, severe infections, neoplastic disorders and obstetric catastrophes. It is characterized by a diffuse and simultaneous activation [...] of the clotting and fibrinolytic systems. The deposit of small thrombi in the circulation eventually leads to dysfunction of multiple organs, and in some cases to death. Clinical findings include thrombotic as well as hemorrhagic manifestations. A simple scoring system has been proposed to aid in the diagnosis of this entity. Treatment includes the specific management of the underlying cause that triggered the DIC, support with blood products in patients with bleeding manifestations and therapeutic anticoagulation in patients with thrombotic events. The development of DIC is an adverse prognostic factor that significantly increases mortality. In this review article the following aspects of CID are included: history, epidemiology, classification, associated diseases, physiopathology, clinical presentation, diagnosis, treatment and prognosis.

Marcos, Arango Barrientos.

2010-12-01

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Linfomas del tubo digestivo y glándulas anexas en pacientes con SIDA. Serie de casos  

Directory of Open Access Journals (Sweden)

linfoma. La incidencia global de linfomas (primarios del sistema nervioso central, no Hodgkin sistémicos y de Hodgkin durante el período de estudio fue de 2,9% (54 casos; 17 pacientes (32% tuvieron diagnóstico de LNH sistémicos; 10 (58,8% de ellos tuvieron presentación extranodal al momento del inicio de las manifestaciones clínicas y 8 (80% comprometieron el tubo digestivo y las glándulas anexas (parótida, cavum, esófago, estómago, duodeno, colon derecho en 2 casos e hígado en el restante, como LNH primarios, de alto grado y de fenotipo "B". Todos los pacientes presentaron síntomas "B" al momento del diagnóstico. De acuerdo con los criterios de estadificación de Lugano, 4 se encontraban en el estadio I, 2 pertenecían al IIa y uno al III y al IV, respectivamente. El linfoma de duodeno fue el único de tipo Burkitt en esta serie y se detectó el genoma del virus de Epstein-Barr en las muestras de biopsias del tumor, así como también en el que comprometió el hígado. Cuatro pacientes recibieron tratamiento con quimioterapia sistémica más factor estimulante de colonias de granulocitos y TARGA; 2 de ellos (cavum y uno de los de colon tienen una sobrevida prolongada con reconstitución inmune luego de 5 y 6 años del diagnóstico, respectivamente. La mediana de supervivencia de los pacientes tratados con TARGA más quimioterapia fue de 33 meses. La mediana de supervivencia de los otros pacientes fue de 90 días. Conclusión: los LNH del tracto gastrointestinal son una grave complicación de la enfermedad VIH/SIDA avanzada. El diagnóstico precoz seguido del tratamiento combinado de quimioterapia más TARGA mejora el pronóstico y la supervivencia de estos pacientes.

Marcelo Corti

2006-01-01

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How Is Disseminated Intravascular Coagulation Treated?  

Science.gov (United States)

... page from the NHLBI on Twitter. How Is Disseminated Intravascular Coagulation Treated? Treatment for disseminated intravascular coagulation (DIC) ... clotting problems and treat the underlying cause. Acute Disseminated Intravascular Coagulation People who have acute DIC may have ...

31

Intravascular Imaging With Ultrasound  

Science.gov (United States)

One of the major unresolved problems in the development of laser angioplasty is in monitoring the process of plaque ablation in real-time to provide the necessary operator feedback. As part of a project to test the feasibility of intravascular imaging with ultrasound we have developed, constructed, and tested a 20 MHz transmitter/receiver which can detect echoes from transducers small enough to fit on a 3-F (1 mm diameter) catheter. Resolution with a small aperture (0.5 x 1.0 mm) focused transducer is about 0.25 mm in both axial and longitudinal directions at 1.5 to 6.0 mm from the transducer face. Images of arteries made in the laboratory with a simple rotational scanner have sufficient resolution to show lumen size and geometry, wall thickness, branches, and craters caused by laser ablation. From these initial studies intravascular ultrasonic imaging appears feasible.

Hartley, Craig J.; Sartori, Michele P.; Henry, Philip D.

1988-04-01

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Intravascular (catheter) MR imaging  

International Nuclear Information System (INIS)

Intravascular MR probes allow excellent spatial resolution and have the potential to detect arterial wall microstructure. Ultrasonic intravascular probes suggest that detailed morphologic information can assist clinical decision making. Catheter MR probes of 2--7 mm outside diameter (OD) were built of copper wire, Teflon, and parts from standard commercial catheters. The probes were connected to the surface coil receiver input of our Picker VISTA 2055HP 1.5-T imaging system. The extant (linear) body coil was used for transmit. Phantoms were constructed of coaxial glass MR tubes, filled with doped water. Watanabe rabbit aorta and human autopsy iliac artery specimens were examined within 4 hours of excision or stored by freezing. In vivo iliac arteries in dogs under general anesthesia were imaged, with percutaneous placement of the probe. Results are presented

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Intravascular lesions of the hand  

OpenAIRE

Abstract Introduction Intravascular lesions of the hand comprise reactive and neoplastic entities. The clinical diagnosis of such lesions is often difficult, and usually requires pathologic examination. We present the largest series to date of intravascular lesions affecting the hand. Methods A retrospective review of intravascular (arterial and venous) lesions involving the hand was conducted. Data regarding clinicopathologic findings were analyzed. Results We identified 10 patients with int...

Duke Wayne H; Pantanowitz Liron

2008-01-01

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Disseminated intravascular coagulation  

OpenAIRE

Disseminated intravascular coagulation (DIC) is a reflection of an underlying systemic disorder which affects the coagulation system, simultaneously resulting in pro-coagulant activation, fibrinolytic activation, and consumption coagulopathy and finally may result in organ dysfunction and death. Though septicaemia is the most common cause of DIC, several other conditions can also lead to it. A diagnosis of DIC should be made only in the presence of a causative factor supported by repeated lab...

Stiehm, E. Richard

2014-01-01

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Linfoma não-Hodgkin de órbita: relato de caso Non-Hodgkin orbital lymphoma: case report  

Directory of Open Access Journals (Sweden)

Full Text Available O objetivo é relatar manifestação incomum de linfoma não-Hodgkin de órbita. Paciente masculino, de 75 anos, se apresentou com queixa de lacrimejamento crônico bilateral. Havia feito dacriocistorrinostomia endonasal à direita e à esquerda por duas vezes, sem sucesso. Ao exame, massas de consistência fibroelástica, em topografia das "bolsas" de gordura das pálpebras inferiores e proptose axial. O paciente negava outros sintomas ou sinais sistêmicos. Hemograma sem alteração, hormônios tireoidianos normais. A tomografia computadorizada mostrava infiltrado difuso na órbita e proptose axial. Biópsia de gordura orbitária e de medula óssea diagnosticaram linfoma não-Hodgkin. O paciente foi tratado com quimioterapia, sendo em seguida submetido à cirurgia da via lacrimal bilateral, com resolução do quadro. A doença sistêmica que exigia diagnóstico e tratamento adequados para que se tivesse bom prognóstico estava mascarada pelo quadro de epífora bilateral.The purpose is to report an unusual case of orbital non-Hodgkin lymphoma. A 75-year-old man presented with bilateral chronic epiphora complaint and inferior eyelid tumors, axial proptosis, without previous systemic manifestation. The patient was submitted to bilateral endonasal dacryocystorhinostomy twice and the epiphora complaint persisted. The inferior eyelid and bone marrow biopsy revealed non-Hodgkin lymphoma. The patient was treated with systemic chemotherapy and dacryocystorhinostomy with good resolution. The precise diagnosis and the treatment were very important to reach a good resolution of the bilateral epiphora complaint.

Cristiane do Prado Silva

2008-04-01

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Linfoma não-Hodgkin de órbita: relato de caso / Non-Hodgkin orbital lymphoma: case report  

Scientific Electronic Library Online (English)

Full Text Available O objetivo é relatar manifestação incomum de linfoma não-Hodgkin de órbita. Paciente masculino, de 75 anos, se apresentou com queixa de lacrimejamento crônico bilateral. Havia feito dacriocistorrinostomia endonasal à direita e à esquerda por duas vezes, sem sucesso. Ao exame, massas de consistência [...] fibroelástica, em topografia das "bolsas" de gordura das pálpebras inferiores e proptose axial. O paciente negava outros sintomas ou sinais sistêmicos. Hemograma sem alteração, hormônios tireoidianos normais. A tomografia computadorizada mostrava infiltrado difuso na órbita e proptose axial. Biópsia de gordura orbitária e de medula óssea diagnosticaram linfoma não-Hodgkin. O paciente foi tratado com quimioterapia, sendo em seguida submetido à cirurgia da via lacrimal bilateral, com resolução do quadro. A doença sistêmica que exigia diagnóstico e tratamento adequados para que se tivesse bom prognóstico estava mascarada pelo quadro de epífora bilateral. Abstract in english The purpose is to report an unusual case of orbital non-Hodgkin lymphoma. A 75-year-old man presented with bilateral chronic epiphora complaint and inferior eyelid tumors, axial proptosis, without previous systemic manifestation. The patient was submitted to bilateral endonasal dacryocystorhinostomy [...] twice and the epiphora complaint persisted. The inferior eyelid and bone marrow biopsy revealed non-Hodgkin lymphoma. The patient was treated with systemic chemotherapy and dacryocystorhinostomy with good resolution. The precise diagnosis and the treatment were very important to reach a good resolution of the bilateral epiphora complaint.

Cristiane do Prado, Silva; Maria Aparecida, Domingues; Silvana Artioli, Schellini; Ligia, Niero.

2008-04-01

37

Linfoma primario de cavidades / Primary effusion lymphoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish El linfoma primario de cavidades es un linfoma no Hodgkin de fenotipo B raro, de alto grado, asociado con el virus herpes humano 8 (VHH-8), y la mayoría de los casos se dan en el seno de una infección por VIH (SIDA). El pronóstico es pobre, con una mediana de supervivencia menor a los 6 meses. Prese [...] ntamos el caso de un varón de 65 años, con una hepatopatía crónica de origen incierto, anemia hemolítica crónica y ascitis. La biopsia del peritoneo evidenció un linfoma primario de cavidades. El paciente falleció dos meses después. Abstract in english Primary effusion lymphoma is a rare high-grade B-cell non-Hodgkin's lymphoma associated with human herpesvirus 8 (HHV-8) infection, and is mostly observed in the course of HIV infection (AIDS). The prognosis is poor, with reported median survival time shorter than 6 months. We present a case of a 65 [...] -year-old man, with prior unknown origin chronic hepatopathy, chronic hemolytic anaemia, and ascitis. El biopsy of peritoneum showed a primary effusion lymphoma. The patient died two month later.

P., Khosravi Shahi; P., Sabin Domínguez; G., Pérez Manga.

2006-09-01

38

Linfoma no Hodgkin fulminante presentándose con acidosis láctica e insuficiencia hepática aguda: reporte de caso y revisión de la literatura  

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Full Text Available La falla hepática causada por neoplasias malignas es rara. Puede ser secundaria a cáncer hepatocelular, metástasis hepáticas, neoplasias secundarias o como complicación de agentes quimioterapéuticos. Las neoplasias hematológicas, como la leucemia, linfoma no Hodgkin y linfoma Hodgkin generalmente no causan falla hepática y más raramente aún producen falla hepática aguda fulminante. Caso clínico: se presenta un hombre de 43 años de edad con diarrea, náuseas y dolor abdominal leve de dos semanas de evolución. Fue tratado con antibióticos orales sin mejoría. Ingresó con falla hepática al departamento de urgencias en donde se lo encontró ictérico, agitado, taquicárdico e hipotenso. Tenía equimosis alrededor de los ojos y tórax, sangrado activo en sitios de venopunción y hematuria macroscópica. El abdomen estaba doloroso con hepatomegalia. Los estudios de laboratorio tenían hallazgos que correspondían a falla hepatorrenal aguda, serología para hepatitis viral negativa, anticuerpos antinucleares negativos y el panel de hierro normal. El ultrasonido abdominal mostró hepatoesplenomegalia. El paciente desarrolló hipoglucemia refractaria y mayor aumento de ácido láctico sérico. Falleció a los cinco días de su admisión. Conclusiones: la falla hepática aguda como presentación inicial de linfoma es rara. Esto puede retrasar el diagnóstico, contribuyendo al mal pronóstico de esta entidad. Establecer el diagnóstico de malignidad como causa de falla hepática aguda es difícil y requiere un alto índice de sospecha. Dado el mal pronóstico asociado con el diagnóstico tardío y los potenciales beneficios de la quimioterapia, se debe considerar al linfoma como causa de falla hepática aguda sin una etiología evidente y asociado a acidosis láctica y hepatomegalia.

Guillermo Flores Padilla

2009-01-01

39

Coagulación intravascular diseminada = Disseminated intravascular coagulation  

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Full Text Available La coagulación intravascular diseminada (CID es una entidad clínica frecuente que se presenta como fenómeno secundario a diversas enfermedades entre las cuales se destacan las infecciones graves, las neoplasias y las catástrofes obstétricas. Se caracteriza por una activación difusa y simultánea de los sistemas endógenos de la coagulación y la fibrinólisis. El depósito de pequeños trombos en la circulación conduce finalmente a disfunción orgánica múltiple y en algunos casos a la muerte. Las manifestaciones clínicas pueden incluir fenómenos trombóticos y hemorrágicos. Se ha propuesto un puntaje de fácil aplicación para simplificar el diagnóstico de la entidad. El tratamiento incluye el control específico de la causa subyacente que favorece la aparición de la CID, el soporte con hemoderivados en pacientes con manifestaciones de sangrado y la anticoagulación terapéutica en pacientes con trombosis mayores. El desarrollo de CID es un factor pronóstico adverso que aumenta significativamente la tasa de mortalidad. En este artículo de revisión se incluyen los siguientes aspectos de la CID: historia, epidemiología, clasificación, entidades asociadas, fisiopatología, clínica, diagnóstico, tratamiento y pronóstico.

Arango Barrientos, Marcos

2010-12-01

40

Linfoma MALT en diferentes localizaciones / MALT lymphoma in different locations  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Se describen 3 casos de pacientes con linfoma MALT, diagnosticados, tratados y seguidos en la consulta de hematología del Hospital Provincial Docente Clinicoquirúrgico "Saturnino Lora" de Santiago de Cuba, a la cual fueron remitidos por gastroenterólogos, otorrinolaringólogos y maxilofaciales de la [...] mencionada institución. Uno de los afectados presentaba una masa tumoral gástrica y en nasofaringe, aparecida en diferentes momentos; otro un tumor linfoide en el paladar duro, que recurrió en ganglios infradiafragmáticos; y un tercero un nódulo linfoide en la glándula salival parótida unilateral, con recidiva en ganglios regionales después de haber sido extirpado. Todos experimentaron una buena respuesta clínica al inicio del tratamiento convencional, pero en 2 de ellos se confirmaron reapariciones no locales del proceso morboso. Abstract in english Three cases of patients with MALT lymphoma are described, who were diagnosed, treated and followed up at the hematology department of "Saturnino Lora" Teaching Provincial Hospital in Santiago de Cuba, to which they were referred by gastroenterologists, otolaryngologists and maxillofacial specialists [...] of that institution. One of those patients presented with a nasopharyngeal and gastric mass, which appeared at different times; another patient had lymphoid tumor of the hard palate, which recurred in infradiaphragmatic lymph nodes; and a third one had a lymphoid node in the unilateral salivary parotid gland with recurrence in regional nodes after having been removed. All experienced a good clinical response at the beginning of conventional treatment, but in 2 of them non-local recurrences of the disease process were confirmed.

Ana Dolores, Izquierdo Calzado; Juan Carlos, Espinosa Expósito; José, Jardón Caballero; Jesús, Díaz Fondén; Frida Yarina, González Núñez.

2012-03-01

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Linfomatosis intravascular cerebral como causa de demencia rápidamente progresiva: Reporte de un caso / Cerebral intravascular lymphomatosis as cause of subacute dementia: Report of a case  

Scientific Electronic Library Online (English)

Full Text Available La linfomatosis intravascular cerebral es un tipo de Linfoma no Hodgkin generalmente de células B, de presentación infrecuente, curso clínico progresivo y fatal. El daño vascular es producto de oclusión de vasos de pequeño calibre por infiltración tumoral, con resultado de múltiples infartos. Las ma [...] nifestaciones neurológicas suelen ser la forma de presentación clínica inicial, caracterizadas por un amplio espectro que incluye encefalopatía subaguda, deterioro cognitivo, delirio, afasia, hemiparesia, trastornos visuales, paraplejia, parestesias y compromiso de pares craneanos. Los estudios de RNM evidencian alteraciones indistinguibles de las vasculitis del SNC. La linfomatosis intravascular debe considerarse en el diagnóstico diferencial de las demencias rápidamente progresivas y en los cuadros de multi infarto cerebral de pequeño vaso de etiología inusual y recurrente. Se presenta el caso de un paciente con demencia rápidamente progresiva, con manifestaciones neurológicas de deterioro cognitivo y enfermedad sistémica. El compromiso del SNC se expresó como encefalopatía subaguda con confusión, agitación, y crisis convulsivas, trastornos motores con reflejo cutáneo plantar extensor bilateral y compromiso cerebeloso, de curso clínico sintomático progresivo, con baja de peso y fiebre fluctuante. El paciente fue sometido a tratamiento con metilprednisolona a pesar del cual falleció. El estudio necrópsico demostró alteraciones por Linfoma no Hodgkin difuso de células B, variante intra vascular, con compromiso del cerebro, cerebelo, glándulas suprarrenales, páncreas, miocardio, tiroides, pulmón riñón e hígado. Abstract in english Cerebral Intravascular Lymphomatosis is a type of non Hodgkin Lymphoma, generally composed with B cells, its ocurrence is infrequent, clinically progressive and has a fatal course. Vascular damage is related with tumoral infiltration and small caliber occlusion, with results in multi infarcts. Neuro [...] logical symptoms and signs are frequently the first clinical manifestation, which include sub acute encephalopathy, cognitive impairment, delirium, aphasia, hemipharesis, visual disturbances, paraplegia, paresthesia and cranial nerves involvement. MRI shows images of vasculitis from CNS. Cerebral Intravascular Lymphomatosis must be considered in differential diagnosis of rapid and subacute dementias, and clinical cases with small vessel recurrent multi infarct of unusual etiology. We present the clinical case of a patient with rapid progressive dementia and systemic disease manifestation. The CNS involvement was characterized as a subacute encephalopathy, with confusion and agitation, seizures, motor disturbances, bilateral plantar extensor reflexes and cerebellar signs. The clinical symptomatic course was progressive, with weight loss and fluctuant fever. The patient had a fatal course after he was treated with Methylprednisolone. Postmortem pathologic examination revealed a diffuse non Hodgkin lymphoma of B cells, intravascular variant, with brain compromise, cerebellum, suprarenal glands, pancreas, myocardium, thyroid gland, lung kidney and the lever.

Paula, Jiménez P; Oscar, Jiménez L; Pía, García F.

2013-03-01

42

Linfoma del manto / Mantle cell lymphoma  

Scientific Electronic Library Online (English)

Full Text Available El linfoma del manto representa el 7% de los linfomas no Hodgkin del adulto. Se trata de una neoplasia de células B monomorfas de talla pequeña o mediana con núcleo irregular. Las células tumorales expresan fuertemente IgM e IgD, así como los antígenos de clase B. La proteína nuclear ciclina D1 está [...] presente en todos los casos, y es el "gold estándar" para el diagnóstico. La traslocación t(11;14) (q13;q32) en la mayoría de los casos da lugar a un reordenamiento del locus BCL-1 y una sobreexpresión del gen de ciclina D1. La mayoría de los pacientes presentan estadios avanzados. El linfoma del manto es una neoplasia incurable, pero puede ser tratada con diferentes esquemas de quimioterapia (R-Hyper-CVAD, R-CHOP, bortezomib) y los pacientes jóvenes podrían ser sometidos a quimioterapia de alta dosis y trasplante de médula ósea autólogo o alogénico. Abstract in english Mantle cell lymphoma accounts for approximately 7% of adult Non-Hodgkin Lymphomas. It is a neoplasm of monomorphous small to medium-sized B cells with irregular nuclei. The tumor cells express strong IgM and IgD, and B-cell-associated antigens. Nuclear cyclin D1 protein is present in all cases and i [...] s the gold standard for the diagnosis. The t(11;14) (q13;q32) in the majority of the cases results in rearrangement of the BCL-1 locus and overexpression of the cyclin D1 gene. Most patients present with disseminated disease. Mantle cell lymphoma is an incurable neoplasm, but it may be treated with different chemotherapy regimen (R-Hyper-CVAD, R-CHOP, bortezomib) and young patients should be considered for high-dose therapy and autologous or allogeneic bone marrow transplantation.

P., Khosravi Shahi; A., del Castillo Rueda; G., Pérez Manga.

2007-03-01

43

Transfusión intrauterina intravascular  

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Full Text Available Objetivo: Evaluar los resultados de 90 transfusiones intrauterinas intravasculares realizadas en 45 fetos afectados por aloinmunización Rh. Método: Descripción del procedimiento de transfusiones intrauterinas intravasculares y presentación de la evaluación y seguimiento prospectivo de 90 transfusiones llevadas a cabo entre el período 1995- 2002. Ambiente: Unidad de Alto Riesgo del Servicio de Prenatal de la Maternidad “Concepción Palacios”. Caracas. Resultados: La edad promedio de las pacientes fue 25,8 años; se realizaron en promedio 2 transfusiones por paciente, con un mínimo de 1 y un máximo de 4; la mayoría de las pacientes tenían antecedentes de importancia como mortinato anterior e historia de enfermedad hemolítica; la principal indicación para realizar la el procedimiento fue la lectura de densidad óptica seguida por el hidrops fetal; la edad promedio para realizar la primera transfusión fue de 25,6 semanas con un mínimo de 20 semanas; los valores de hemoglobina fetal previa a la primera oscilaron entre 2 y 11,3 g/dL ascendiendo posterior a la transfusión a valores entre 5 y 15,3 g/dL; la sobrevida total fue de 69 % y al analizar sólo los fetos sin hidrops la sobrevida ascendió a 84,37 %. Conclusiones: La prevención con el uso de inmunoglobulina anti Rh D es definitivamente el mejor protocolo para evitar la anemia fetal por aloinmunización Rh, cuando se produce la enfermedad hemolítica intrauterina el mejor tratamiento es la reposición de sangre a través del cordón umbilical. En nuestro trabajo confirmamos que se debe adquirir una amplia experiencia en el manejo de las transfusiones intrauterinas para de esta forma prolongar la vida intrauterina y así alcanzar mayor madurez y probabilidad de sobrevida neonatal con menores riesgos y complicaciones.Objective: To present the results of 90 intrauterine intravascular transfusions performed in 45 Rh isoinmunized fetuses. Method: Description of the intrauterine intravascular transfusion´s procedure and presentation of evaluation and prospective floow up of 90 transfusions practiced from 1995 to 2002. Setting: High Risk Unit of Prenatal Service at Maternidad Concepción Palacios. Caracas. Results: The mean age of patients was 25.8 years; the number of transfusions ranged from one to tour (the mean was two; most patients had important records of fetal death and hemolytic disease; transfusion was mainly prescribed after optical density values followed by fetal hydrops. Gestational age for the first procedure was 25.6 weeks with a minimum of 20 weeks; fetal haemoglobin values prior to the first transfusion ranged between 2-11.3 g/dL increasing to 5-15.3 g/dL post transfusion. Total survival was 69 % and increased to 84.37 % in the nonhydropic group. Conclusion: Prevention using antiRhD inmunoglobulin is definitively the best protocol when avoiding fetal anaemia due to Rh isoimmunization. When intrauterine hemolytic disease occurs, blood transfusion through umbilical cord seems to be the best option. In our experience, we confirmed that the accumulation of experience in intrauterine intravascular transfusion is needed in order to extend intrauterine life and so achieve a higher neonatal outcome along with less risk and complications.

Freddy González Arias

2006-06-01

44

Complicaciones neurológicas en pacientes con linfomas  

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Full Text Available Se realizó un estudio descriptivo prospectivo en 270 pacientes con diagnóstico de linfoma ingresados en el Servicio de Hematología del Hospital Clinicoquirúrgico "Hermanos Ameijeiras" de Ciudad de La Habana, Cuba, en el período comprendido del 1ro de marzo de 1996 al 31 de diciembre de 1998, para conocer las complicaciones neurológicas. Se detectaron 26 pacientes con complicaciones neurológicas. De 188 enfermos con linfomas no-Hodgkin, el 12,2 % presentó manifestaciones neurológicas. En estos pacientes, la infiltración leptomeníngea fue la complicación neurológica más frecuente. En los 82 pacientes con enfermedad de Hodgkin, solamente 3,6 % tuvieron alteraciones neurológicas y la infección por Herpes zoster fue la más común. Se observó el mayor porcentaje de pacientes con síntomas y signos atribuibles a compresión de la médula espinal y a la alteración de pares craneales, la cefalea como el síntoma más común y el déficit motor, el signo más frecuente. Se comprobó que los pacientes con linfoma no Hodgkin de alto grado de malignidad presentaron el mayor porcentaje de complicaciones neurológicas (28,7 % y el tiempo promedio entre el diagnóstico del linfoma y el diagnóstico de la complicación neurológica fue menor en estos enfermos (5,5 meses. El tiempo de supervivencia después del diagnóstico de las manifestaciones neurológicas en la mayoría de los pacientes fue inferior a un año. De los 14 pacientes fallecidos, la complicación neurológica fue la principal causa directa de la muerteA prospective and descriptive study was carried out in 270 patients diagnosed of lymphoma, admitted in Hematology Service of "Hermanos Ameijeiras" Clinical Surgical Hospital in Havana City, Cuba, from March 1, 1996 to December 31, 1998, to assess neurologic complications. 26 patients presenting with neurologic complications were detected. From 188 sick persons with non-Hodgkin's lymphoma, 12,2 % had neurologic manifestations. In these patients, leptomeninges infiltration was the more frequent neurologic complication. In 82 patients with Hodgkin's disease, only 3,6 % had neurologic alteration and Herpes zoster infection was the commonest one. We found higher percent of patients with syndromes attributable to spinal cord compression and to craneal pars disturbance, headache was commonest and motor deficit the more frequent one. It was confirmed that patients carriers of high grade malinancy non-Hodgkin' s lymphoma, had the great percentage of neurologic complications (28,7 %, and average time between diagnosis of lymphoma and that of neurologic complications was shorter in these patients was (5,5 months. Survival after diagnosis of neurologic manifestations in most patients was under l year. In 14 patients deceaced, neurologic complication was main direct cause of death

Nelson Gómez Viera

2000-06-01

45

Linfoma não Hodgkin gástrico Gastric non-Hodgkin Lymphoma  

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Full Text Available Os linfomas extralinfonodais representam aproximadamente 1/3 de todos os linfomas não Hodgkin (LNH e, embora possam ter início em qualquer tecido, mais frequentemente acometem o trato gastrointestinal, sendo o estômago o órgão responsável pela grande maioria dos casos. Os linfomas primários gástricos são comumente LNH, sendo representados em mais de 95% dos casos pelo linfoma difuso de grandes células B e pelo linfoma MALT (mucosa associated lymphoid tissue. De evolução indolente, o linfoma MALT destaca-se por ser um modelo de câncer secundário à estimulação antigênica crônica exercida por uma bactéria denominada Helicobacter pylori (HP. No outro polo, situa-se o linfoma difuso de células B (LDGCB, que, de patogênese duvidosa, pode tratar-se de uma transformação de LNH MALT ou ainda se caracterizar por um linfoma "de novo". Neste estudo, revisamos a literatura, enfatizando aspectos importantes à prática clínica destes linfomas.Extranodal lymphomas account for about 30% of all non-Hodgkin lymphomas (NHL, and although they can originate in any tissue, the gastrointestinal tract is the most commonly affected structure with the stomach being the most common subtype. Diffuse Large B cell lymphoma (DLBCL and MALT (mucosa associated lymphoid tissue lymphoma account for more than 95% of the cases of gastric lymphoma. The indolent development of MALT lymphoma stands out as it is a type of cancer subject to chronic antigen stimulation by the Helicobacter pylori bacteria. Conversely, diffuse large B cell lymphomas, whose pathogenesis is uncertain, can be a transformation from MALT NHL or perhaps a new type of lymphoma. In this study we carried out a review of the literature, stressing the key aspects of these lymphomas in the clinical practice.

Renata O. Costa

2010-02-01

46

Linfoma não Hodgkin gástrico / Gastric non-Hodgkin Lymphoma  

Scientific Electronic Library Online (English)

Full Text Available Os linfomas extralinfonodais representam aproximadamente 1/3 de todos os linfomas não Hodgkin (LNH) e, embora possam ter início em qualquer tecido, mais frequentemente acometem o trato gastrointestinal, sendo o estômago o órgão responsável pela grande maioria dos casos. Os linfomas primários gástric [...] os são comumente LNH, sendo representados em mais de 95% dos casos pelo linfoma difuso de grandes células B e pelo linfoma MALT (mucosa associated lymphoid tissue). De evolução indolente, o linfoma MALT destaca-se por ser um modelo de câncer secundário à estimulação antigênica crônica exercida por uma bactéria denominada Helicobacter pylori (HP). No outro polo, situa-se o linfoma difuso de células B (LDGCB), que, de patogênese duvidosa, pode tratar-se de uma transformação de LNH MALT ou ainda se caracterizar por um linfoma "de novo". Neste estudo, revisamos a literatura, enfatizando aspectos importantes à prática clínica destes linfomas. Abstract in english Extranodal lymphomas account for about 30% of all non-Hodgkin lymphomas (NHL), and although they can originate in any tissue, the gastrointestinal tract is the most commonly affected structure with the stomach being the most common subtype. Diffuse Large B cell lymphoma (DLBCL) and MALT (mucosa asso [...] ciated lymphoid tissue) lymphoma account for more than 95% of the cases of gastric lymphoma. The indolent development of MALT lymphoma stands out as it is a type of cancer subject to chronic antigen stimulation by the Helicobacter pylori bacteria. Conversely, diffuse large B cell lymphomas, whose pathogenesis is uncertain, can be a transformation from MALT NHL or perhaps a new type of lymphoma. In this study we carried out a review of the literature, stressing the key aspects of these lymphomas in the clinical practice.

Renata O., Costa; Abrahão E., Hallack Neto; Dalton A. F., Chamone; Vera Lúcia, Aldred; Luis F., Pracchia; Juliana, Pereira.

2010-02-01

47

Intravascular large B cell lymphoma  

OpenAIRE

Intravascular large B cell lymphoma (IVBCL) is a rare type of extranodal large B cell lymphoma characterized by selective growth of lymphoma cells within the microvasculature. We present an illustrative case of intravascular B cell lymphoma suspected by the presence of a very small monoclonal B cell population identified by immunophenotype and polymerase chain reaction in bone marrow. The diagnosis was confirmed by skin biopsy.

Garci?a-mun?oz, Ricardo; Rubio-mediavilla, Susana; Robles-de-castro, Diego; Mun?oz, Aura; Herrera-pe?rez, Pilar; Rabasa, Pilar

2014-01-01

48

Tejido linfoide y linfomas gástricos / Lymphoid tissue and gastric lymphomas  

Scientific Electronic Library Online (English)

Full Text Available En este artículo hemos realizado una amplia revisión de los linfomas primarios gástricos, su clasificación y aspectos clínico-patológicos más importantes, haciendo énfasis especial en los linfomas MALT o asociados a las mucosas y su relación con la infección por Helicobacter pylori. [...] Abstract in english In this review we describe various aspects of the primary gastric lymphomas, the classification, and the most important clinico-pathological aspects, with emphasis in mucosa associated lymphoma (MALT) and the Helicobacter pylori infection. [...

Rocío del Pilar, López P; Rafael Enrique, Andrade P.

2010-12-30

49

Linfoma metastásico cardíaco / Metastatic Cardiac Lymphoma  

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Full Text Available SciELO Argentina | Language: Spanish Abstract in spanish Los tumores cardíacos secundarios o metastásicos son unas 20-40 veces más comunes que los primitivos benignos y malignos. Las neoplasias que con más frecuencia producen metástasis en el corazón son los carcinomas pulmonares, los de mama, los melanomas malignos y, en una proporción menor, las leucosi [...] s y los linfomas. En esta presentación se describe el caso de una paciente femenina, de 36 años, con síntomas cardiovasculares de arritmia y síncope y evidencia ecocardiográfica de tumor cardíaco de crecimiento acelerado. Debido al agravamiento de las manifestaciones clínicas, se inició tratamiento con esteroides sistémicos, con el que experimentó mejoría clínica en las primeras 72 horas. Esto llevó a enfocar el diagnóstico en una causa secundaria de invasión cardíaca. Los hallazgos histopatológicos de una biopsia gástrica evidenciaron la presencia de un linfoma no Hogdkin. Se inició el tratamiento citostático específico; la paciente se encuentra en remisión y con regresión total de sus síntomas cardiovasculares. En nuestra paciente llama la atención la forma de presentación de los síntomas, que estuvieron limitados a la esfera cardiovascular pese a la localización en el sistema digestivo del tumor primario. Abstract in english Secondary or metastatic cardiac tumors are 20 to 40 times more common than primary benign or malignant neoplasms. Lung and breast carcinoma, malignant melanoma, and, to a lesser degree, leukemia and lymphoma, often metastasize to the heart. We describe the case of a 36-year old female patient with a [...] rrhythmia and echocardiographic evidence of a rapidly growing heart tumor. Treatment with systemic corticosteroids was initiated due to symptoms aggravation and the patient improved within 72 hours. A metastatic tumor was then suspected. A gastric biopsy confirmed the presence of a non-Hodgkin lymphoma. Specific cytostatic treatment was started; the patient remains in remission with complete regression of cardiovascular symptoms. Interestingly, our patient presented only cardiovascular symptoms despite the primary tumor was located in the digestive system.

Sheila, Hechavarría Pouymiró; Roberto, Marrero Mederos; Juan, Valiente Mustelier; Francisco, Cabrera.

2011-04-01

50

Linfoma T subcutâneo do tipo paniculite: relato de um caso acometendo paciente pediátrico  

OpenAIRE

Os autores relatam um caso de linfoma T subcutâneo do tipo paniculite em uma paciente feminina de 3 anos, apresentando havia um mês múltiplos nódulos subcutâneos, indolores, disseminados no abdome, região peitoral e cervical. Ao exame histopatológico, evidenciou-se um linfoma T infiltrando tecido adiposo subcutâneo. Os linfomas T subcutâneos representam uma entidade clinicopatológica distinta, sendo raro o acometimento pediátrico.

Noronha Lúcia; Medeiros Fabiola; Prevedello Luciano Monte Serrat; Martins Vanessa Dello Monaco; Watanabe Flora; Fillus Neto José

2001-01-01

51

QUIMIOTERAPIA COMBINADA NEOADYUVANTE SEGUIDA DE RADIOTERAPIA EXTERNA EN EL TRATAMIENTO DE DOS CASOS DE LINFOMA PRIMARIO DEL CUELLO UTERINO  

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Full Text Available Los linfomas primarios del cuello uterino son poco frecuentes. Dado que no hay esquemas de manejo definido, presentamos 2 nuevos casos tratados y controlados desde 1999 a la fecha en la Fundación Arturo López Pérez. El tratamiento consistió en quimioterapia combinada neoadyuvante seguida de radioterapia externa. Se verificó respuesta clínica y radiológica completa en ambos casos. Conclusión: Se puede lograr respuesta completa de estas neoplasias linfoides con esta modalidad de tratamientoBackground: Primary extranodal lymphomas of the genital tract are rare. Cases: As there is no current consensus in its management, we present two further cases and their treatment with neoadyuvant chemotherapy, followed by radiation therapy. A radical hysterectomy with bilateral pelvic lymphadenectomy was performed after primary treatment in one case. Clinical response was complete in both cases and pathological response was documented in one. Conclusions: Complete response of these lymphoid neoplasms can be achieved by neoadyuvant chemotherapy followed by external irradiation

Marco Bravo S.

2005-01-01

52

Intravascular blood coagulation after irradiation  

International Nuclear Information System (INIS)

The problems of activation of intravascular blood coagulation (JVBC) at different stages after irradiation, are considered. JVBC peculiarities (disseminated intravascular syndrome (DIV) or thrombo hemorrhagic syndrome) are investigated. Literature on alterations which take place in the organism under effect of ionizing irradiation is analyzed. This analysis proves the characteristic features of thrombinogenesis activation and development of DIV syndrome not only in the early post-radiation period, but in the middle of radiation disease, as well. It is also shown that ionizing radiation activizes the hemocoagulation process and causes IVBC in the case of both local and general irradiation

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Manifestaciones pulmonares en pacientes con linfomas  

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Full Text Available Se realizó un estudio descriptivo en 88 pacientes con linfomas (25 con enfermedad de Hodgkin y 63 con linfoma no Hodgkin atendidos en el Hospital Clinicoquirúrgico "Hermanos Ameijeiras" desde abril de 1997 hasta diciembre de 1998, para identificar las manifestaciones pulmonares. Se estudiaron los síntomas y signos del aparato respiratorio y los resultados de la radiografía del tórax en todos los pacientes. En 79 de ellos se realizaron pruebas funcionales respiratorias. Predominaron los pacientes asintomáticos (69/88; 78,4 % (p A descriptive study was conducted in 88 patients with lymphomas (25 Hodgkin’s disease and 63 non-Hodgkin’s lymphoma seen at "Hermanos Ameijeiras" Clinical and Surgical Hospital from April 1997 to December 1998. Its objective was to identify the pulmonary manifestations. Symptoms and signs of the respiratory system and chest Rx results were analyzed in all the patients. Seventy-nine of them underwent respiratory function testing. Asymptomatic patients prevailed (69/88 for 78,4 % (p < 0,01; the most frequent respiratory symptom was cough (6/25 for 24 % in Hodgkin’s disease and 10/63 for 15,8 % in non-Hodgkin’s lymphomas. A high number of patients did not present alterations when they were applied a respiratory physical exam (73/88 for 82,9 % (p < 0,01; the reduction of vesicular breath sounds was the most frequent disturbance (15/88 for 17 %. It was observed that chest radiology was normal in more than half of the cases (53/88 for 60.2% (p = 0,025 and mediastinal adenopathies were the most frequent disorders (30/88 for 34 %. Alterations in X-rays were mostly found in Hodgkin’s disease (18/25 for 72 % that non-Hodgkin´s lymphoma (17/63, 27 %. The respiratory function tests were normal in 74.7 % of the cases (59/79 (p < 0,01 whereas slight restrictive ventilatory disorder was more detected (9/79 for 11,4 %. Data revealed that in the group of studied patients, the frequency of pulmonary manifestations is similar to the one reported by other authors and that there are neither pathognomonic respiratory symptoms nor signs for each type of lymphoma.

Jesús Diego de la Campa

2002-04-01

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Primary testicular non-Hodgkin's lymphoma: a review article / Linfoma primário do testículo: um artigo de revisão  

Scientific Electronic Library Online (English)

Full Text Available O linfoma primário do testículo (LPT) foi descrito como uma entidade clínica pela primeira vez em 1866. É uma doença rara e corresponde a 1% de todos os linfomas não-Hodgkin, 2% de todos os linfomas extranodais e 5% de todos as neoplasias testiculares. É o tumor testicular mais comum em homens entre [...] 60 e 80 anos de idade. LPT é único em sua elevada incidência de envolvimento bilateral (8-38%), sendo o tumor testicular bilateral mais comum. Tem uma predileção por disseminação para regiões extranodais não-contíguas, especialmente para o sistema nervoso central (SNC). Estágios avançados da doença são usualmente tratados com quimioterapia à base de doxorubicina. Para os estágios mais precoces, as opiniões são divergentes quanto à quimioterapia associada à orquiectomia. A alta prevalência de disseminação, especialmente para o SNC, sugere o uso de quimioterapia intratecal como profilaxia. Estudos prospectivos multicêntricos incluindo um grande número de pacientes poderiam resolver a questão com relação ao manejo deste subtipo de linfoma não-Hodgkin. Abstract in english Primary testicular non-Hodgkin's lymphoma was first described as a clinical entity in 1866. It is a rare disease and accounts for 1% of all non-Hodgkin's lymphoma, 2% of all extranodal lymphomas and 5% of all testicular neoplasms. It is the most common testicular tumor in males between sixty and eig [...] hty years of age. Testicular non-Hodgkin's lymphoma is unique in its high incidence of bilateral involvement (8-38%), and it is also the most common bilateral testicular tumor. Testicular non-Hodgkin's lymphoma has a predilection for spreading to non-contiguous extranodal sites, especially the central nervous system. Advanced-stage disease is usually managed with doxorubicin-based chemotherapy. For early-stage disease, opinion is divided regarding systemic chemotherapy following orchidectomy. The high incidence of spreading, especially to the central nervous system, leads to advocacy of the use of central nervous system prophylaxis with intrathecal chemotherapy. Prospective multicenter trials incorporating a large number of patients may lead to better guidelines for optimal management of this subtype of non-Hodgkin's lymphoma.

Komal, Bhatia; Ashok Kumar, Vaid; Sachin, Gupta; Dinesh Chandra, Doval; Vineet, Talwar.

2007-09-01

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Linfoma de celulas B de la zona marginal extraganglionar del tejido linfoide asociado a mucosa (linfoma MALT de pulmón  

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Full Text Available Los Linfomas Pulmonares Primarios son extremadamente raros (0,4% de los linfomas extraganglionares, y generalmente son de tejido linfoide asociado a mucosas (tipo MALT, con ocasionales linfomas de células grandes difusos. Los síntomas son inespecíficos, y casi la mitad de los pacientes son asintomáticos. Se presenta el caso de un paciente masculino de 56 años de edad, quien presentó durante 7 meses accesos diarios de tos seca, de predominio nocturno, asociados en el último mes a fiebre de 39ºC, disnea a medianos esfuerzos y expectoración verduzca. Los exámenes de laboratorio fueron normales. La radiografía de tórax mostró el mediastino ensanchado, un proceso en lóbulo medio con efecto atelectásico, y un nódulo en hemitórax izquierdo. La tomografía computarizada (TC torácica de alta resolución evidenció proceso alveolar derecho en lóbulo medio y un nódulo pulmonar izquierdo calcificado de tipo inespecífico. El estudio inmunohistoquímico de la biopsia pulmonar fue compatible con Linfoma de Células B de la zona marginal extraganglionar del tejido linfoide asociado a mucosa (Linfoma MALT de pulmón. La TC corporal y la Tomografía por Emisión de Positrones (PET evidenciaron importantes hallazgos complementarios para determinar la extensión de la enfermedad. El paciente se trato con quimioterapia y actualmente se encuentra en buenas condiciones, sin recidiva de la sintomatología. Dado lo infrecuente de la patología se presenta este caso y se hace una revisión de la literatura

Carlos Vergara-Uzcategui

2014-09-01

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Quinine induced disseminated intravascular coagulopathy  

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Full Text Available There are only a handful of case reports of DisseminatedIntravascular Coagulopathy (DIC as a result of quinine usehowever it is important to recognise this early especiallywhen quinine has not been prescribed for managingmalaria. Off licence use of any medicine may result inserious complications, quinine induced DIC is one of them.

Nikolaus Hammerl

2011-09-01

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Quinine induced disseminated intravascular coagulopathy  

OpenAIRE

There are only a handful of case reports of Disseminated Intravascular Coagulopathy (DIC) as a result of quinine use however it is important to recognise this early especially when quinine has not been prescribed for managing malaria. Off licence use of any medicine may result in serious complications, quinine induced DIC is one of them.

Nikolaus Hammerl; Muhammad Kashif Nadeem

2011-01-01

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Linfoma no Hodgkin extraganglionar. Reporte de un caso  

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Full Text Available El linfoma no Hodgkin extraganglionar es un trastorno linfoproliferativo crónico de causa aún dudosa. Se reporta un caso de una paciente con una masa tumoral a nivel del anillo de Waldeyer, se realizó el diagnóstico por biopsia de la lesión de un linfoma no Hodgkin de alto grado de malignidad extraganglionar. Se inició tratamiento con esquema ChopBleo y se obtuvo repuesta favorable, presentó recaída hematológica dos años más tarde, por lo que se inició tratamiento con radioterapia de cabeza y cuello con resultados alentadores. Actualmente se mantiene asintomática.

Jos\\u00E9 Ignacio Larquin Comet

2008-01-01

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Incidencia de linfoma gastrointestinal en el hospital militar Dr. Carlos Arvelo en el lapso 2003-2008 un período de 5 años  

Scientific Electronic Library Online (English)

Full Text Available Los Linfomas No Hodgkin del tracto gastrointestinal son los linfomas extranodales más comunes, representando entre el 30 y 70% de esta última patología constituyendo un grupo heterogéneo de tumores con diferentes características clínicas y patológicas. El estómago está lesionado de manera predominan [...] te siendo los linfomas tipo MALT los tumores de bajo grado más frecuentes en el sistema gastrointestinal, contando con 40% de todos los linfomas gástricos primarios, manteniéndose localizados por períodos prolongados sin tratamiento. Objetivos: evaluar la epidemiología de los linfomas gastrointestinales en nuestro centro. Pacientes y métodos: Análisis retrospectivo de las historias de pacientes con diagnóstico de Linfoma Gastrointestinal. Resultados: Se presentan datos clínicos e histopatológicos de 20 pacientes con diagnóstico de Linfoma Gastrointestinal tratados en el Hospital Militar "Dr. Carlos Arvelo", Caracas, Venezuela, desde 2003 a 2008. 15 hombres, 5 mujeres, con edades comprendidas entre 23 y 64 años. De ellos, 14 (70 %) se presentaron con enfermedad limitada (estadio I-II) mientras que 6 (30%) tuvieron lesión de varios órganos (hígado, páncreas, bazo, duodeno) o más de un órgano gastrointestinal, siendo clasificado como estadio IV. 11 pacientes tuvieron linfoma gástrico, 2 de páncreas, 1 hepático esplénico y de columna lumbar, 1 intestino delgado, 1 en bazo, 4 de colon, y en 5 pacientes se observaron multiples localizaciones en el sistema gastrointestinal. Dolor abdominal, hemorragia digestiva, pérdida de peso fueron los síntomas más frecuentes de presentación. El estómago fue el órgano mas frecuentemente lesionado. Abstract in english Non-Hodgkin´s lymphomas (NHL) of the gastrointestinal (GI) tract are the most common extra nodal lymphomas. They represent between 30% to 70% of all extra nodal lymphomas and constitute a heterogeneous group of tumors with different clinical and pathological features. The stomach is predominantly in [...] volved. MALT type lymphomas are the most frequent low grade non-Hodgkin´s lymphomas encountered in the GI tract. They account for 40% of all primary gastric lymphomas and remain, in the majority of cases, localized for a prolonged period of time without therapy. Aim: To evaluate the epidemiology of gastrointestinal lymphomas in our Hospital. Patients and Methods: Retrospective analysis of patientÊs recorders performed at the Hospital Militar "Dr. Carlos Arvelo", Caracas, that had the diagnosis of gastrointestinal lymphoma. Results Clinical and histopathologjcal data from 20 patients presenting with GI-NHL treated from 2003 until 2008, were reviewed. 15 men, 5 women with an age range between 23 and 64 years old. Of these, 14 (70%) presented with limited disease (stage I and II), while 6 patients were found to have disease involvement of other abdominal organs (i.e., liver, pancreas, spleen, duodenum) or more than one gastrointestinal site and were therefore classified as stage IV. 11 patients presented with lymphoma in the stomach, 2 pancreatic, 1 in liver, spleen and lumbar vertebrae, 1 in the small intestine and 4 in the large bowel, while in 5 cases multiple localizations of the gastrointestinal tract were documented. Abdominal pain, gastrointestinal bleeding, weighs loose were the main presenting symptom.

Beatriz, Pernalete; María Alejandra, La Cruz; Livia, Rodríguez; Sylvia, Benítez; Oscar, Pérez; Rosanna, Bonardo; Noheltriz, Camaray; Francisco, Guzman; Lorena, Villarreal; Jacinto, Lara.

2009-12-01

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Hypothesis: disseminated intravascular inflammation as the inflammatory counterpart to disseminated intravascular coagulation.  

OpenAIRE

We have identified a leukocyte activation syndrome that is occasionally associated with the transfusion of intraoperatively recovered erythrocytes. This syndrome appears to result from intravascular damage caused by leukocytes activated during the erythrocyte salvage process. We hypothesize that this syndrome is part of a larger disease grouping: disseminated intravascular inflammation (DII). DII is the analog of the coagulation disorder disseminated intravascular coagulation. In disseminated...

Bull, B. S.; Bull, M. H.

1994-01-01

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Estudio histológico e inmunofenotípico de linfoma canino en el centro de México  

OpenAIRE

El inmunofenotipo constituye un factor importante en el pronóstico del linfoma canino. Se ha demostrado que perros con linfoma de células B presentan tiempos de sobrevivencia más largos que los perros con linfoma de células T. Los antígenos CD3 y CD79a son los marcadores más utilizados en inmunohistoquímica para la determinación del fenotipo celular T y B, respectivamente, en muestras fijadas en formalina y conservadas en bloques de parafi na. En este estudio se describen las caracter...

Lvarez Berger, Francisco J. U. C.; Ndez, Enrique Aburto Fern U. E.; Gerardo Aristi Urista; Vez Gris, Gilberto Ch U. E.

2009-01-01

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Murine neonatal intravascular injections: Modeling newborn disease  

Science.gov (United States)

The ability to perform murine neonatal intravascular injections likely will prove useful in studying many newborn-specific disease states that are modeled in mice. Unfortunately, effective intravascular injection in the neonatal mouse has been limited by developmental immaturity and small size. To e...

63

Primary lymphoma of the colon / Linfoma primario de colon  

Scientific Electronic Library Online (English)

Full Text Available Introducción: el linfoma primario de colon y recto es una patología poco prevalente, representa tan solo el 0,5 % de todas las neoplasias primarias de colon y recto. El tracto gastrointestinal es el lugar donde asientan la gran mayoría de los linfomas extranodales, siendo el más frecuente el tipo li [...] nfoma no-Hodking. El diagnóstico precoz es siempre difícil debido a que la sintomatología es muy poco específica. Los algoritmos terapéuticos han incluido clásicamente la resección radical, el tratamiento con quimioterapia y con radioterapia. Materiales y métodos: presentamos nuestra experiencia en el manejo de los linfomas primarios de colon en un periodo de 17 años (1994-2011). Resultados: en dicho periodo en nuestro centro fueron diagnosticaron 7 casos de linfoma primario de colon. El dolor abdominal y los cambios en el ritmo deposicional fueron los síntomas más frecuentes. Cinco pacientes requirieron tratamiento quirúrgico urgente debido a hemorragia digestiva u obstrucción intestinal. El estudio anatomopatológico reveló que todos los linfomas tenían el fenotipo de tipo B. Los pacientes tuvieron un seguimiento medio de 59 meses (rango 1-180). Tres de ellos siguen vivos sin evidencia de recidiva. Conclusión: el tratamiento combinado con quimioterapia y cirugía puede obtener buenos resultados de remisión. La cirugía puede resolver complicaciones como la hemorragia o la perforación intestinal, ambas directamente relacionadas con la mortalidad por linfoma. Abstract in english Background: primary colorectal lymphoma is a very rare disease, representing less than 0.5 % of all primary colorectal neoplasms. The gastrointestinal tract is the most frequently involved site of all extranodal lymphomas, the most common type of that is non-Hodgkin's lymphoma. Early diagnosis is of [...] ten difficult because of unspecific symptoms. Therapeutic approaches have classically included radical resection, chemotherapy and radiotherapy. Materials and methods: we present our experience in the management of primary colorectal lymphomas over a 17-year period (1994-20011). Results: in this period 7 cases of primary colorectal lymphoma were diagnosed in our institution. Abdominal pain and change in bowel habit were the most frequent symptoms. Five patients underwent emergency surgery because of bleeding or bowel obstruction. All primary intestinal lymphomas studied were of the B-cell phenotype. Patients were followed up for a median of 59 months (range 1-180). Three of them are alive with no evidence of recurrence. Conclusion: combination treatment with chemotherapy and surgery can obtain good remission rate. Surgery can resolve complications such bleeding or intestinal perforation that are implicated in lymphoma mortality.

Marta, Pascual; Blanca, Sánchez-González; Mar, García; Miguel, Pera; Luis, Grande.

2013-02-01

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Asociación de linfomas malignos con herpes virus I y II  

Scientific Electronic Library Online (English)

Full Text Available SciELO Peru | Language: Spanish Abstract in spanish Objetivos: Conocer la prevalencia de la seropositividad para herpes virus I y II en pacientes con linfomas non Hodgkin y su asociación con el linaje celular (B ó T). Pacientes y métodos: Se tomó una muestra de 60 pacientes en el Hospital Almenara de agosto de 1999 a diciembre del 2000 todos ellos pa [...] cientes con diagnostico establecido de linfoma non Hodgkin nuevos o en primera recaída, el análisis se realizó mediante bioestadística descriptiva. Resultados: La mediana de la edad fue de 59 años, 2/3 fueron varones, 65% pacientes nuevos y el linfoma primario fue extraganglionar en un 58% de los casos. El 80% de los linfomas fueron a células B y mas del 90% en estadios avanzados (III y IV), ningún caso fue positivo para IgM herpes I o II y 25% tuvieron serología positiva IgG para herpes I o II (2/3 positivos para IgG I) de los cuales el 93% fueron a células B. Conclusiones: La prevalencia de seropositividad para herpes virus I y II en pacientes con linfoma non Hodgkin es del 25%, mayormente asociado a células B, además de tener un porcentaje considerable de linfomas a células T (25%) y linfomas extranodales (58%); para evaluar la posibilidad de asociación entre este virus y los linfomas requerimos de un estudio caso-control. Abstract in english Objectives: To know the prevalence of seropositivity for herpes virus I and II in patients with malignant non Hodgkin lymphoma (NHL), and the association with the cell lineage (B or T). Patients and Methods: We considered 60 new or in first recurrence patients with NHL at the Hospital Nacional Guill [...] ermo Almenara from August 1999 to December 2000. We analyzed the data by descriptive biostatistics in Epi-Info program. Results: Median age was 59 years, two thirds were men, 65% were new patients and the primary site was extranodular in 58% of the cases. 80% were NHL to B cells, and more than 90% in advance stage (III and IV), none of them were positive for IgM herpes virus I or II and 25% were positive for IgG I or II (2/3 positive for IgG I) and more than 90% of them were for B cell. Conclusion: The prevalence of seropositivity for herpes I or II in patients with NHL was 25%, usually associated to B cells, on the other hand we have an elevated percentage of T cell NHL (25%) as well as extranodular NHL (58%). We need more studies specially a case-control study to define the association of herpes virus I or II with NHL.

Ashley Efraín, Alarcon-Rozas; Fernando, Salas Sánchez; Karina, Villacres Vela; Julio, Guevara Guevara.

2002-04-01

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Acantosis nigricans y linfoma no Hodgkin: presentación de un caso  

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Full Text Available Fundamento: la acantosis nigricans fue la primera dermatosis en la que se reconoció un carácter paraneoplásico. La característica sobresaliente es la hiperpigmentación simétrica y el engrosamiento aterciopelado de la piel. Se sugiere que algún factor producido por el tumor estimula el crecimiento epidérmico. Objetivo: presentar un caso poco frecuente de un paciente con el diagnóstico de linfoma no Hodgkin y acantosis nigricans. Caso clínico: se presenta el caso de un paciente masculino de 62 años de edad con antecedentes de hipertensión arterial que un año previo a su ingreso manifestó cambios en la coloración de la piel, dermatosis generalizada, hiperpigmentación e hiperqueratosis en las palmas de las manos y el cuello. Conclusiones: el tumor más frecuente asociado con acantosis es el adenocarcinoma abdominal en 90 % de los casos, entre los cuales 64 a 69 % son de origen gástrico; el resto (10 % se asocian con cáncer no digestivo; linfoma de Hodgkin, micosis fungoide, cáncer de esófago, próstata y tiroides. En el linfoma no Hodgkin su asociación es considerada muy rara y son pocos los casos reportados en la bibliografía.

Miguel Dami\\u00E1n Junco Bonet

2014-01-01

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Intravascular hemolysis in aluminium phosphide poisoning.  

Science.gov (United States)

Intravascular hemolysis is most often secondary to exposure to a variety of drugs or infections, and usually occurs in patients who are deficient in glucose-6-phosphate dehydrogenase (G-6-PD) enzyme. Aluminium phosphide, a fumigant widely used in India, has been reported to produce intravascular hemolysis in only one patient who also had concomitant G-6-PD deficiency. This report describes the occurrence of intravascular hemolysis with aluminium phosphide poisoning in a patient with normal G-6-PD levels. This is of significance as jaundice in patients with this poisoning is often attributed to hepatic damage alone. PMID:10496516

Aggarwal, P; Handa, R; Wig, N; Biswas, A; Saxena, R; Wali, J P

1999-09-01

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Acute Disseminated Intravascular Coagulation in Neuroendocrine Carcinoma  

Science.gov (United States)

Malignancy is a common cause of disseminated intravascular coagulation and usually presents as a chronic disorder in solid organ tumours. We present a rare case of recurrent acute disseminated intravascular coagulation in neuroendocrine carcinoma after manipulation, firstly, by core biopsy and, later, by cytotoxic therapy causing a release of procoagulants and cytokines from lysed tumour cells. This is reminiscent of tumour lysis syndrome where massive quantities of intracellular electrolytes and nucleic acid are released, causing acute metabolic imbalance and renal failure. This case highlights the potential complication of acute disseminated intravascular coagulation after trauma to malignant cells. PMID:23139666

Teh, Ru-Wen; Tsoi, Daphne T.

2012-01-01

68

Obstetrical disseminated intravascular coagulation score.  

Science.gov (United States)

Obstetrical disseminated intravascular coagulation (DIC) is usually a very acute, serious complication of pregnancy. The obstetrical DIC score helps with making a prompt diagnosis and starting treatment early. This DIC score, in which higher scores are given for clinical parameters rather than for laboratory parameters, has three components: (i) the underlying diseases; (ii) the clinical symptoms; and (iii) the laboratory findings (coagulation tests). It is justifiably appropriate to initiate therapy for DIC when the obstetrical DIC score reaches 8 points or more before obtaining the results of coagulation tests. Improvement of blood coagulation tests and clinical symptoms are essential to the efficacy evaluation for treatment after a diagnosis of obstetrical DIC. Therefore, the efficacy evaluation criteria for obstetrical DIC are also defined to enable follow-up of the clinical efficacy of DIC therapy. PMID:24888908

Kobayashi, Takao

2014-06-01

69

Dosimetric model for intravascular brachytherapy  

International Nuclear Information System (INIS)

Full text: Intravascular brachytherapy has been shown to be a prophylaxis for restenosis. Adventitial macrophages, which are extremely radiosensitive, initiate neointima formation. A model of the dose levels of the treatment range is developed, assuming that the adventitia is the target tissue. If the adventitia receives a dose of less than 10 Gy, it is assumed the treatment will be ineffective. If the dose to any part of the wall is above 30 Gy, it is assumed that the treatment could be detrimental. Hence the treatment range is between 10 and 30 Gy, with 20 Gy being the optimum dosage to the adventitia. An algorithm using numerical integration of published dose kernels calculates the dose at any point surrounding a beta (32P) line source of finite length. Dose profiles were obtained to demonstrate edge effects. For long lesions, the source is often stepped along the artery. Dose changes due to separation or overlapping of sources during source stepping procedures were also determined. Isodose curves were superimposed on intravascular ultrasound images to demonstrate dose levels. For an exposure time of 60 seconds with a 200mCi source, the optimum dose of 20 Gy occurs at a distance 1.94mm from the centre of the source. The upper limit of the treatment dose range (30 Gy) occurs at 1.59mm. The lower limit of the treatment dose range (10 Gy) occurs at 2.7mm. Significant perturbations to the treatment dose range can be caused by non-centering of the source, edgcaused by non-centering of the source, edge effects and separation or overlapping of sources in stepping procedures. Despite these concerns, many successful procedures have been reported and this implies that the model is over simplified and requires modifications. Copyright (2000) Australasian College of Physical Scientists and Engineers in Medicine

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Pulmonary intravascular lipid in neonatal necropsy specimens.  

Science.gov (United States)

The lungs of 482 liveborn infants were examined at necropsy for the presence of intravascular lipid. Forty one patients had received parenteral feeding (including lipid emulsion in 30), and 441 had died before starting feeds or had received enteral feeds alone. Tissue was processed into wax and then stained with Sudan black; intravascular lipid was found in 15 of 30 infants who had received intravenous fat (Intralipid), but in no others. Those patients with positive lipid staining had received significantly more fat during parenteral nutrition than those in whom intravascular lipid was not found but the two groups were otherwise clinically indistinguishable. Using this staining technique intravascular lipid can be shown relatively often, although only in patients who have received intravenous lipid emulsion. The location of fat, predominantly in small pulmonary capillaries, and the absence of lipid emboli in other organs, suggests that lipid coalescence takes place before death and is not a postmortem artefact. The clinical relevance remains uncertain. PMID:1899990

Puntis, J W; Rushton, D I

1991-01-01

71

Disseminated intravascular coagulation with Fusobacterium necrophorum septicaemia.  

OpenAIRE

A 23 year old woman died within six hours of admission from acute disseminated intravascular coagulation. Fusobacterium necrophorum, a Gram negative anaerobic organism, was isolated as a single pathogen from the blood cultures. This association has not previously been reported.

Potter, M. N.; Drysdale, H. C.; Price, P. A.; Buck, A. C.

1988-01-01

72

LINFOMA CUTÁNEO PRIMARIO DE CÉLULAS B, DEL TIPO DE LA PIERNA / PRIMARY CUTANEOUS B CELL LYMPHOMA, LEG TYPE / LINFOMA CUTÂNEO PRIMÁRIO DE CÉLULAS B, DO TIPO DA PERNA  

Scientific Electronic Library Online (English)

Full Text Available O linfoma de células B do tipo da perna é uma neoplasia rara e agressiva, com características clínicas, morfológicas e imunofenotípicas distintivas. Está classificado dentro do grupo de linfomas cutâneos primários de células B e se apresenta em idades avançadas, com predomínio em mulheres e altas ta [...] xas de recorrência. Apresentamos o caso de uma mulher de 63 anos de idade, com diagnóstico clínico e inmunofenotípico de linfoma cutâneo de células B do tipo da perna. Abstract in spanish El linfoma de células B del tipo de la pierna, es una neoplasia rara y agresiva, con características clínicas, morfológicas e inmunofenotípicas distintivas. Está clasificada dentro del grupo de linfomas cutáneos primarios de células B y se presenta en edades avanzadas, con predominio en mujeres y al [...] tas tasas de recurrencia. Presentamos el caso de una mujer de 63 años de edad, con diagnóstico clínico e inmunofenotípico de linfoma cutáneo de células B del tipo de la pierna. Abstract in english Primary cutaneous B?cell lymphoma, leg type, is an uncommon and aggressive neoplasm with unique clinical features, morphology and immunophenotype. It is classified as a primary B?cell cutaneous lymphoma and it occurs in advanced age and women with high rates of recurrences. We present the case of a [...] 63?year?old woman, with clinical and immunophenotypic diagnosis of primary cutaneous B?cell lymphoma, leg type.

LINA MARÍA, BONILLA JARAMILLO; JORGE ENRIQUE, CALDERÓN; CHALELA, JUAN GUILLERMO; MARÍA ISABEL, GONZÁLEZ.

2012-12-01

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Acute Disseminated Intravascular Coagulation in Neuroendocrine Carcinoma  

OpenAIRE

Malignancy is a common cause of disseminated intravascular coagulation and usually presents as a chronic disorder in solid organ tumours. We present a rare case of recurrent acute disseminated intravascular coagulation in neuroendocrine carcinoma after manipulation, firstly, by core biopsy and, later, by cytotoxic therapy causing a release of procoagulants and cytokines from lysed tumour cells. This is reminiscent of tumour lysis syndrome where massive quantities of intracellular electrolytes...

Teh, Ru-wen; Tsoi, Daphne T.

2012-01-01

74

Linfomas cutáneos: Aspectos relevantes Cutaneous lynphomas: Significant aspects  

Directory of Open Access Journals (Sweden)

Full Text Available Los linfomas cutáneos constituyen un amplio grupo dentro de los linfomas no hodgkinianos. Incluyen varios tipos de desórdenes linfoproliferativos y se clasifican según su origen en T ó B, cuadro clínico y morfología. Dentro de estos se encuentran la micosis fungoides y el síndrome de Sézary, que son entidades que aunque difieren en sus manifestaciones clínicas, se cree que son variantes de un mismo trastorno linfoproliferativo del linfocito T CD4. Estos linfomas no hodgkinianos de células T aparecen entre los 40 y 60 años y es 2,2 veces más frecuente en el sexo masculino que en el femenino. Un adecuado tratamiento depende de un exacto diagnóstico morfológico, inmunológico, genético y molecular que permitiría una más rápida remisión, una mayor sobrevida y la incorporación de estos individuos a la vida útil de la sociedad.The cutaneous lymphomas constitute a large group within the non-Hodgkin lymphomas. They include various types of lymphoproliferative disorders and they are classified according to their origin, clinical picture and morphology in T or B. The fungoid mycosis and Sézary's syndrome are among them. Although these entities differ in their clinical manifestations, it is believed that they are variants of a same lymphoproliferative disorder of the CD4 T-lymphocyte. These non-Hodgkin lymphomas of T-cells appear in individuals aged 40-60 and they are two times more frequent in males than in females. An adequate treatment depends on an accurate morphological, immunological, genetic and molecular diagnosis that will allow a faster remission, a higher survival and the incorporation of these individuals to society's useful life.

Bertha Beatriz Socarrás Ferrer

2005-04-01

75

Apresentação cutânea inicial de linfomas na infância Initial cutaneous manifestation of lymphomas in children  

Directory of Open Access Journals (Sweden)

Full Text Available Os linfomas cutâneos compreendem um grupo heterogêneo de desordens linfoproliferativas que envolvem a pele e são classificados como um subgrupo dos linfomas não Hodgkin. No período de 1981 a 2007, 100 casos de linfomas em crianças foram admitidos no Serviço de Hematologia, do Hospital das Clínicas da Universidade Federal de Minas Gerais, sendo que nove apresentaram manifestação cutânea inicial. Três pacientes foram classificados como linfoma cutâneo primário e seis como sistêmicos. Sete pacientes apresentaram linfoma de células T, um, linfoma linfoblástico B e um, imunofenótipo indefinido. Nenhum óbito ocorreu nos pacientes com linfoma cutâneo primárioCutaneous lymphomas comprise a heterogeneous group of lymphoproliferative disorders with skin involvement and are classified as a subgroup of non-Hodgkin lymphomas. From 1981 to 2007, 100 children with non-Hodgkin lymphomas were admitted to the Hematology Unit of the Federal University of Minas Gerais Teaching Hospital. In nine of these children, the skin was involved at the onset of the disease. Three patients were classified as having primary cutaneous lymphoma, while in six the disease was systemic with cutaneous involvement. In seven patients, the immunophenotype was T-cell, in one it was B-cell, and in the remaining case the immunophenotype was indefinable. No deaths occurred in any of the children with primary cutaneous lymphoma

Maria Christina Lopes Araujo de Oliveira

2011-08-01

76

Apresentação cutânea inicial de linfomas na infância / Initial cutaneous manifestation of lymphomas in children  

Scientific Electronic Library Online (English)

Full Text Available Os linfomas cutâneos compreendem um grupo heterogêneo de desordens linfoproliferativas que envolvem a pele e são classificados como um subgrupo dos linfomas não Hodgkin. No período de 1981 a 2007, 100 casos de linfomas em crianças foram admitidos no Serviço de Hematologia, do Hospital das Clínicas d [...] a Universidade Federal de Minas Gerais, sendo que nove apresentaram manifestação cutânea inicial. Três pacientes foram classificados como linfoma cutâneo primário e seis como sistêmicos. Sete pacientes apresentaram linfoma de células T, um, linfoma linfoblástico B e um, imunofenótipo indefinido. Nenhum óbito ocorreu nos pacientes com linfoma cutâneo primário Abstract in english Cutaneous lymphomas comprise a heterogeneous group of lymphoproliferative disorders with skin involvement and are classified as a subgroup of non-Hodgkin lymphomas. From 1981 to 2007, 100 children with non-Hodgkin lymphomas were admitted to the Hematology Unit of the Federal University of Minas Gera [...] is Teaching Hospital. In nine of these children, the skin was involved at the onset of the disease. Three patients were classified as having primary cutaneous lymphoma, while in six the disease was systemic with cutaneous involvement. In seven patients, the immunophenotype was T-cell, in one it was B-cell, and in the remaining case the immunophenotype was indefinable. No deaths occurred in any of the children with primary cutaneous lymphoma

Maria Christina Lopes Araujo de, Oliveira; Luciana Baptista, Pereira; Priscila Cezarino, Rodrigues; Keyla Cunha, Sampaio; Benigna Maria de, Oliveira; Marcos Borato, Viana.

2011-08-01

77

Pain in an osseous lymphoma. A case presentation. Dolor en el linfoma oseo. Presentación de un caso.  

Directory of Open Access Journals (Sweden)

Full Text Available This is a 79 year-old, white, male patient suffering from osseous lymphoma, a less frequent illness, came to the university Hospital Dr. Gustavo Aldereguía Lima¨ in Cienfuegos city, Cuba complaining of intercostal pain in the left hemithorax. This pain was not relieved with the regular medical treatment, that´s why the anesthesia service doctors gave assistance. Costal osteolysis at level D7, D8 and D9 were shown in a thorax X ray. He was treated with analgesic through peridural via such as morphine, local anesthetic. Betametasone was used as anti-inflammatory having positive results. The use of ethylic alcohol as agents contributed to the patient´s improvement and to get back to his normal life. 

Se presenta el caso de un paciente del hospital provincial clínico quirúrgico universitario ¨Dr. Gustavo Aldereguía Lima¨ de Cienfuegos, portador de una enfermedad muy poco frecuente (linfoma óseo, de 79 años de edad, masculino, de raza blanca, que refería dolor intercostal en hemitórax izquierdo, el cual no cedía ante el tratamiento médico habitual, por lo que es atendido por anestesiología. En el rayos X de tórax se apreció osteolisis costal a nivel de D7, D8 y D9. En forma frecuente fue tratado con analgésicos por vía peridural: morfina, anestésicos locales y como antiinflamatorio la betametasona con resultados satisfactorios. El uso de agentes como el alcohol etílico, contribuyó a mejorar su cuadro y a que se incorporara a sus labores habituales.

Alexis Guillén Sánchez

78

Diffuse large B-cell lymphoma of the oral cavity / Linfoma difuso de células B grandes de la cavidad bucal  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: English Abstract in spanish Se reporta un caso de linfoma difuso de células B grandes (DLBL) de la cavidad bucal. Se trata de un paciente masculino, blanco, de 73 años de edad, que se presentó a la División de Estomatología, con una masa nodular difusa en el paladar duro y una lesión nodular en el labio superior, diagnosticada [...] s como DLBL. El paciente fue tratado con ocho ciclos de quimioterapia CHOP (ciclofosfamida, doxorrubicina, vincristina, prednisona), pero se constató recidiva de la enfermedad en ambos sitios primarios, en el paladar duro y en el labio superior a los 22 meses después del término de la terapia. El paciente fue sometido de nuevo a la quimioterapia. Abstract in english The authors report a case of diffuse large B-cell lymphoma (DLBL) of the oral cavity. The patient was a 73-year-old white man who first presented at the Division of Stomatology with a large nodular mass in the hard palate and a nodular lesion in the upper lip, which were diagnosed as DLBL. The patie [...] nt was treated with eight cycles of CHOP chemotherapy (cyclophosphamide, doxorubicin, vincristine and prednisone), but the disease recurred 22 months after the end of the therapy. Both primary sites hard palate and upper lip were involved again and the patient was resubmitted to chemotherapy.

Marcelo, Carlos Bortoluzzi; Jonas, Dantas Batista; Karen, Cherubini; Fernanda, Gonçalves Salum; Maria Antonia, Figueiredo.

2010-09-01

79

Linfoma primário de cólon: relato de caso Primary colorectal lymphoma: case report  

OpenAIRE

O linfoma colorretal primário é uma doença rara (0.2 a 0.6% de todas as neoplasias colônicas), apresentando pior prognóstico quando comparado com o linfoma gástrico primário ou com o adenocarcinoma do cólon. É uma doença com sintomatologia inespecífica, o que dificulta o diagnóstico precoce. O objetivo deste relato é mostrar um caso de linfoma primário do cólon, revisar critérios diagnósticos e tratamento.The primary colorectal lymphoma is a rare disease (0.2 to 0.6% of all c...

Rafael Luís Luporini; Antonio Carlos Roma Júnior; Elaine Cristina Henrique Almeida; Marcelo Rodolfo Marciano; Luiz Vagner Sipriani; Francisco de Assis Gonçalves Filho; Alexandre Lopes de Carvalho; Marcelo Maia Caixeta Melo; Luís Sérgio Ronchi; Geni Satomi Cunrath; João Gomes Netinho

2010-01-01

80

Diagnóstico de Linfoma no Hodgkin con infiltración intra-auricular / No Hodgkin Linfoma diagnosis with intra-atrial infiltration  

Scientific Electronic Library Online (English)

Full Text Available Los tumores cardíacos, son entidades raras en la práctica médica, tienen una incidencia del 0,05%, aproximadamente el 75% es benigno y un 25% maligno. De estos el linfoma es infrecuente representando alrededor del 0,25%. Los linfomas no Hodgkin pueden ser extranodales en el 20% de los casos, así mis [...] mo el 80% de los linfomas no Hodgkin son de células B difusos, que es la forma más frecuente de presentación en adultos jóvenes; corresponden a alto grado de malignidad y crecimiento rápido, pueden presentarse con infiltración primaria a diferentes órganos, con afectación cardiaca en 20 a 28% de los casos y suelen localizarse en las cavidades derechas. Los síntomas son inespecíficos, dependientes de la localización y extensión del tumor y la prueba diagnóstica en estos casos es indudablemente la biopsia ya sea del ganglio linfático o del tejido afectado. Se presenta un caso de linfoma no Hodgkin difuso, de células grandes con afectación intra-auricular derecha, en una paciente de 23 años que debutó con disnea progresiva. Se realizó un ecocardiograma transesofágico que detectó una masa tumoral intra-auricular derecha, por lo que se realizó biopsia por cateterismo venoso por vía femoral, que permitió hacer el diagnóstico histopatológico y establecer el tratamiento, con lo cual se encuentra en primera remisión completa a un año del evento Abstract in english Cardiac tumors are rare entities in clinical practice, with an incidence of 0.05%. Approximately 75% are benign and 25% malignant. Among these, Lymphomas are uncommon, representing about 0.25%. The non-Hodgkin lymphomas can occur in extranodal tissues in 20% of the cases and 80% of these non-Hodgkin [...] lymphomas are composed of diffuse B cells. The extranodal presentation is most frequent in young adults, with a high degree of malignancy and rapid growth. It can present with primary infiltration of various organs; cardiac involvement occurs in 20 to 28% of cases, usually located in the right chambers and with nonspecific symptoms, depending on the location and extent of the tumor. The diagnostic test in these cases is undoubtedly the biopsy of the lymph node or the affected tissue. We present the case of non-Hodgkin disease of diffuse large cells, with right intra-atrial involvement in a 23-year-old-female patient, who presented with progressive dyspnea. A transesophageal echocardiography was performed and an intra-atrial tumor mass was detected. A biopsy was performed, by femoral venous catheterization, allowing the establishment of the histopathological diagnosis and treatment. At a one year follow up, the patient shows complete remission

Marco Antonio, Alcocer Gamba; Salvador León, González; Eliodoro, Castro Montes; Luis Martín, Loarca Piña; Leslie Marisol, Lugo Gavidia; Enrique, García Hernández; Ulises, González Galindo; Miguel Isaías, Paredes Serrano.

2012-09-01

81

[Literature review of intravascular lymphomatosis].  

Science.gov (United States)

Intravascular lymphoma (IVL) is a rare form of malignant lymphoma characterized by the selective growth of lymphoma cells within the lumina of vessels, without the involvement of adjacent parenchymal tissue. IVL is predominantly of B-cell lineage, but cases of T-cell or natural killer cell lineage have been described occasionally, predominantly involving the skin. IVL usually affects elderly patients with a poor performance status, elevated serum lactic dehydrogenase levels, anemia, and B symptoms. The clinical presentation varies in different geographical areas, particularly between patients diagnosed in Europe and Asia. In European countries, the Western variant of IVL mainly involves the central nervous system and skin; in particular, there is a "cutaneous variant" limited to the skin. In Asian countries, the Asian variant of IVL predominantly accompanies hemophagocytic syndrome. Identification of this disease is difficult because it presents with non-specific clinical symptoms. Although organ biopsies are mandatory for accurate IVL diagnosis, no standard procedure has been established. An additional random skin biopsy may be useful to diagnose IVL at an early stage. Early diagnosis and treatment can improve the outcome of IVL patients following treatment with rituximab-containing chemotherapy. PMID:25082315

Koyano, Shigeru; Hashiguchi, Shunta; Tanaka, Fumiaki

2014-08-01

82

É possível diferenciar derrames pleurais linfocíticos secundários a tuberculose ou linfoma através de variáveis clínicas e laboratoriais? / Differentiating between tuberculosis-related and lymphoma-related lymphocytic pleural effusions by measuring clinical and laboratory variables: Is it possible?  

Scientific Electronic Library Online (English)

Full Text Available OBJETIVO: Descrever características clínicas e laboratoriais em pacientes com derrames pleurais linfocíticos secundários a tuberculose ou linfoma, a fim de identificar as variáveis que possam contribuir no diagnóstico diferencial dessas doenças. MÉTODOS: Estudo retrospectivo com 159 pacientes adulto [...] s HIV negativos com derrame pleural linfocítico secundário a tuberculose ou linfoma (130 e 29 pacientes, respectivamente) tratados no Ambulatório da Pleura, Instituto do Coração, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo (SP), entre outubro de 2008 e março de 2010. RESULTADOS: A média de idade e de duração dos sintomas foi menor no grupo tuberculose que no grupo linfoma. Os níveis pleurais de proteínas, albumina, colesterol, amilase e adenosina desaminase (ADA), assim como os níveis séricos de proteínas, albumina e amilase, foram maiores no grupo tuberculose, enquanto os níveis séricos de colesterol e triglicérides foram maiores no grupo linfoma. As contagens de leucócitos e linfócitos no líquido pleural foram maiores no grupo tuberculose. Células malignas estavam ausentes no grupo tuberculose, entretanto, linfócitos atípicos foram observados em 4 desses pacientes. No grupo linfoma, a citologia para células neoplásicas foi positiva, suspeita e negativa em 51,8%, 24,1% e 24,1% dos pacientes, respectivamente. A imunofenotipagem do líquido pleural foi conclusiva na maioria dos pacientes com linfoma. CONCLUSÕES: Nossos resultados demonstram semelhanças clínicas e laboratoriais entre os pacientes com tuberculose ou linfoma. Embora os níveis de proteínas e ADA no líquido pleural tendam a ser mais elevados no grupo tuberculose que no grupo linfoma, mesmo essas variáveis mostraram uma sobreposição. Entretanto, nenhum paciente com tuberculose apresentou níveis de ADA no líquido pleural inferiores ao ponto de corte (40 U/L). Abstract in english OBJECTIVE: To describe clinical and laboratory characteristics in patients with tuberculosis-related or lymphoma-related lymphocytic pleural effusions, in order to identify the variables that might contribute to differentiating between these diseases. METHODS: This was a retrospective study involvin [...] g 159 adult HIV-negative patients with tuberculosis-related or lymphoma-related lymphocytic effusions (130 and 29 patients, respectively), treated between October of 2008 and March of 2010 at the Pleural Diseases Outpatient Clinic of the University of São Paulo School of Medicine Hospital das Clínicas Heart Institute, in the city of São Paulo, Brazil. RESULTS: Mean age and the mean duration of symptoms were lower in the tuberculosis group than in the lymphoma group. The levels of proteins, albumin, cholesterol, amylase, and adenosine deaminase (ADA) in pleural fluid, as well as the serum levels of proteins, albumin, and amylase, were higher in the tuberculosis group, whereas serum cholesterol and triglycerides were higher in the lymphoma group. Pleural fluid leukocyte and lymphocyte counts were higher in the tuberculosis group. Of the tuberculosis group patients, none showed malignant cells; however, 4 showed atypical lymphocytes. Among the lymphoma group patients, cytology for neoplastic cells was positive, suspicious, and negative in 51.8%, 24.1%, and 24.1%, respectively. Immunophenotyping of pleural fluid was conclusive in most of the lymphoma patients. CONCLUSIONS: Our results demonstrate clinical and laboratory similarities among the patients with tuberculosis or lymphoma. Although protein and ADA levels in pleural fluid tended to be higher in the tuberculosis group than in the lymphoma group, even these variables showed an overlap. However, none of the tuberculosis group patients had pleural fluid ADA levels below the 40-U/L cut-off point.

Leila, Antonangelo; Francisco Suso, Vargas; Eduardo Henrique, Genofre; Caroline Maris Neves de, Oliveira; Lisete Ribeiro, Teixeira; Roberta Karla Barbosa de, Sales.

2012-04-01

83

Dosimetry in intravascular brachytherapy; Calculos dosimetricos em braquiterapia intravascular  

Energy Technology Data Exchange (ETDEWEB)

Among the cardiovascular diseases responsible for deaths in the adult population in almost all countries of the world, the most common is acute myocardial infarction, which generally occurs because of the occlusion of one or more coronary arteries. Several diagnostic techniques and therapies are being tested for the treatment of coronary artery disease. Balloon angioplasty has been a popular treatment which is less invasive than traditional surgeries involving revascularization of the myocardium, thus promising a better quality of life for patients. Unfortunately, the rate of restenosis (re-closing of the vessel) after balloon angioplasty is high (approximately 30-50% within the first year after treatment).Recently, the idea of delivering high radiation doses to coronary arteries to avoid or delay restenosis has been suggested. Known as intravascular brachytherapy, the technique has been used with several radiation sources, and researchers have obtained success in decreasing the rate of restenosis in some patient populations. In order to study the radiation dosimetry in the patient and radiological protection for the attending staff for this therapy, radiation dose distributions for monoenergetic electrons and photons (at nine discrete energies) were calculated for blood vessels of diameter 0.15, o,30 and 0.45 cm with balloon and wire sources using the radiation transport code MCNP4B. Specific calculations were carried out for several candidate radionuclides as well. Two s tent sources (metallic prosthesis that put inside of patient's artery through angioplasty) employing {sup 32} P are also simulated. Advantages and disadvantages of the various radionuclides and source geometries are discussed. The dosimetry developed here will aid in the realization of the benefits obtained in patients for this promising new technology. (author)

Campos, Laelia Pumilla Botelho

2000-03-01

84

Linfoma primario de pene / Primary lymphoma of penis  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish Se describe un caso de linfoma primario de pene en un paciente de 71 años. Se revisa la bibliografía destacando su extrema rareza y las diferentes formas clínicas de presentación. La clínica fue insidiosa, y los datos de la exploración física y los hallazgos ecográficos la hicieron indistinguible de [...] otras neoplasias. La resonancia magnética confirmó la existencia de un proceso neoformativo de densidad homogénea en la parte distal del pene, cuya toma biópsica junto con las técnicas de inmunohistoquímica confirmó el diagnóstico de linfoma de pene. El tratamiento combinado de quimio y radioterapia permitió conservar el órgano, encontrándose el paciente a los 48 meses libre de enfermedad. Abstract in english We describe a case of primary penis lymphoma in a 71yr old man. We review the bibliography and we emphasize the peculiarity and different sorts of clinical presentation. The initial symptoms were insidious. Physical examination and ultrasound findings made it indistinguishable from other tumors. A M [...] RI confirmed the presence of a tumoral process with a homogeneous density in the distal part of the penis whose biopsy with immune histological processing confirme us the diagnosis of primary penis lymphoma. The combined treatment with chemotherapy and radiotherapy allowed preserving the sexual organ and being without disease at 48 month of follow up.

Lluis, Ibarz Servio; Montserrat, Arzoz Fábregas; José M., Ruiz Domínguez; Montserrat, Batlle Massana; José L., Mate Sanz; José M., Saladié Roig.

2009-08-01

85

Intravascular Stenting in Microvascular Anastomoses  

DEFF Research Database (Denmark)

Background?The effect of intravascular stenting (IVaS) on microvascular anastomoses has given adverse results. For experienced microsurgeons the benefit of IVaS is doubtful. We have investigated the potential benefit of the IVaS technique for two groups of inexperienced microsurgeons with different surgical levels of experience (medical students and young residents). Experienced microsurgeons acted as a control group. Materials and Methods?In an experimental crossover study, 139 microsurgical anastomoses were performed on the femoral artery in 70 rats by 10 surgeons. On one side of the rat, the IVaS technique was used. A small piece of 5-0 nylon monofilament was placed in the vessel lumen, acting as a temporary stent during microvascular anastomosis. A conventional technique without the stent was performed on the other side. Patency rates of the vessels in each group were compared as well as the time spent on the anastomosis. Results?No significant difference in patency rates was seen between the stenting andconventional technique in all three groups. The experienced microsurgeons had 100% patency rate with both techniques. The medical students had 20/28 in the IVaS and 19/28 conventional group and the patency rates for the residents were 23/27 using IVaS and 23/28 using the conventional technique. The residents were faster using the IVaS whereas the students and experienced microsurgeons were faster without the stent. Conclusion?The IVaS technique did not seem to benefit either the inexperienced or experienced microsurgeons regardless of their clinical experience. The study also shows that some surgical experience seems to be an advantage in performing microsurgery.

Assersen, Kristine; SØrensen, Jens

2015-01-01

86

The radiobiology of intravascular irradiation  

International Nuclear Information System (INIS)

Purpose: There is increasing interest in the use of vascular irradiation, from an internally introduced radioactive source to control restenosis after balloon angioplasty. Both animal experiments and early clinical studies appear to show promising results in this regard. We consider various mechanistic interpretations of the experimental and clinical observations that doses of 12-20 Gy appear to be efficacious in preventing restenosis. We develop and investigate simple models, both experimental and theoretical, of the kinetics of radiation-induced smooth muscle cell (SMC) inactivation and regrowth, as a first step toward optimizing the design of clinical vascular irradiation. Methods and Materials: Using in vitro models of human SMCs, we investigate the relative radiosensitivity of SMCs compared with endothelial cells and measure the dose-dependent ability of SMCs to repopulate a denuded region in a confluent layer of cells. We then use quantitative information on the number, radiation sensitivity, and growth rate of the potential arterial target cells to model the time course of the SMC population after irradiation. Results and Conclusion: Doses >20 Gy, which would be required to completely eliminate the SMC population which has the potential to cause restenosis, are too large to be practical because of the unacceptable risk of late complications. However, doses that can be practically given in vascular irradiation (<20 Gy) will certainly delay restenosis by 1-3 yearill certainly delay restenosis by 1-3 years, with larger doses producing longer delays. Whether such doses can avert restenosis permanently is unclear, as permanent prevention at realistic doses depends critically on the assumption that those SMCs which survive irradiation have a significantly limited capacity for proliferation. With regard to current animal model experiments, routine follow-up of <1 year, which is standard practice, is probably too short to address some of the key mechanistic question in intravascular radiation therapy

87

Linfoma primario de páncreas en un paciente de 27 anos de edad. Reporte de un caso  

OpenAIRE

Los linfomas representan una pequeña fracción de todas las neoplasias malignas de páncreas, siendo inferior al 1 o 2%, y es aún más extremadamente extraño en individuos menores de 35 años, por lo que presentamos caso de linfoma primario de páncreas en un paciente de 27 años de edad, que presentó ictericia y dolor abdominal, como única sintomatología. El ultrasonido abdominal solo reportó litiasis biliar mixta, por lo que se programó cirugía electiva para colecistectomía y expl...

Andrea Fargier Paoli; Estrella Celeste Uzcátegui Paz; Fabiana Noboa; Plata Patin?o, Jose L.

2013-01-01

88

Processos linfoproliferativos da pele: parte 2 - linfomas cutâneos de células T e de células NK  

OpenAIRE

Os linfomas cutâneos de células T/NK constituem um grupo de doenças linfoproliferativas extranodais atualmente classificadas e subdivididas de acordo com o comportamento clínico segundo consenso da Organização Mundial de Saúde e da Organização Européia para Pesquisa e Tratamento do Câncer. Os linfomas cutâneos de células T/NK de comportamento clínico indolente compreendem a micose fungóide clássica, a micose fungóide foliculotrópica, a reticulose pagetóide, a cútis laxa gr...

Sanches Jr. José Antonio; Moricz Claudia Zavaloni M. de; Festa Neto Cyro

2006-01-01

89

Linfoma primario del sistema nervioso central en pacientes inmunocompetentes / Primary central nervous system lymphoma in immunocompetent patients  

Scientific Electronic Library Online (English)

Full Text Available SciELO Mexico | Language: Spanish Abstract in spanish El linfoma primario del sistema nervioso central ha sido informado con frecuencia en pacientes que padecen síndromes de inmuno deficiencia. Sin embargo ésta no es una condición necesaria para su presentación, dado que existen informes de la enfermedad en sujetos inmunológicamente competentes. En el [...] presente trabajo se analizaron en forma retrospectiva, los expedientes de 22 pacientes inmunocompetentes con diagnóstico confirmado de linfoma primario encefálico, se revisó la literatura mundial, con el fin de analizar objetivamente las manifestaciones clínicas, comportamiento radiológico, aspecto histopatológico, dificul tades diagnósticas y terapéuticas, así como las consideraciones pro nósticas. El promedio de edad fue de 65 años y con una relación equitativa hombre/mujer. El tiempo de evolución del cuadro clínico fue de 80.4 días y estuvo dominado por cefalea y déficit neurológico focal. En cuatro pacientes se encontraron lesiones múltiples, mientras que en el resto se trataba de lesiones únicas con localización predominante en la región periventricular de los hemisferios cerebrales. Todos los pacientes fueron manejados inicialmente con esteroides y sometidos a toma de biopsia por estereotaxia. La variedad histológica más frecuente fue la de células grandes difusas y la totalidad de los casos reaccionaron positivamente a antígenos de células B en la inmunohistoquímica. Los 22 pacientes fueron tratados con radio terapia y 10 de ellos además con quimioterapia con metotrexato. La supervivencia promedio fue de 11 meses en los pacientes radiados y de 36 meses en los que se agregó quimioterapia. Abstract in english Primary central nervous system lymphoma has been traditionally described in patients with immunodeficiency syndromes; however, there is an increasing number of immunocompetent patients with this type of tumor that have been reported recently. In this paper we have retrospectively analyzed 22 immunoc [...] ompetent patients with a confirmed diagnosis of primary lymphoma of the brain. The mean age in this group was 65 years with a similar male/female ratio. The time of evolution of the clinical course was 80.4 days and it was mainly characterized by headache and focal neurological deficit. In four patients multiple lesions were observed, while the remaining presented single lesions mainly located in the periventricular area of the cerebral hemispheres. All patients were initially administered steroids and a stereotactic biopsy was performed. The majority of tumors were histologically classified as diffuse large cells and all of them showed a positive reaction to B cells antigens on immunohistochemistry. All patients were treated with radiotherapy and in 10 of them, chemotherapy with methotrexate was also indicated. The mean survival rate was 11 months among patients treated with radiotherapy alone and increased to 36 months when chemotherapy was added.

Gerardo, Guinto-Balanzar; Ignacio, Félix-Espinoza; Salvador, De Anda Ponce-de -León; Norma C, Aréchiga-Ramos; Víctor, Arteaga-Larios; Kalman, Kovacs.

2005-12-01

90

Argyrophilic Fibers of Intravascular Threadlike Structures in Rat  

Directory of Open Access Journals (Sweden)

Full Text Available Objective : We took intravascular threadlike structures from rat aortas to investigate their histological characteristics consistent with the intravascular Bonghan duct. Methods : Gomori’s silver impregnation method, in addition to routine hematoxylin and eosin staining, was applied to demonstrate the characteristic feature of the intravascular threadlike structures. Results : These two staining methods clearly showed that the intravascular threadlike structures had unique features of argyrophilic reticular fibers and heavily stained oval or rod-shaped nuclei in them. Conclusion : The results are strong evidences for identifying threadlike structure as the intravascular Bonghan duct.

Byung-Cheon Lee

2008-09-01

91

Transplante de células-tronco hematopoéticas em linfoma Hodgkin / Stem cell transplantation in Hodgkin lymphoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese O linfoma Hodgkin(LH) é uma malignidade hematológica que conta com um armamentário terapêutico selecionado de acordo com o estadiamento e a classificação prognóstica de cada doente. A sobrevida dos pacientes tratados para o LH clássico vem aumentando significativamente, com taxas de cura entre 80%-8 [...] 5%. Entretanto, 20%-25% são refratários aos tratamentos iniciais e cerca de 30% recaem após ter alcançado resposta completa. Os pacientes considerados com falha à terapia de primeira linha ainda têm uma segunda chance de cura se apresentarem quimiossensibilidade aos esquemas de salvamento, seguido por uma das modalidades de transplante de células-tronco hematopoéticas (TCTH). O TCTH autólogo representa uma estratégia atrativa para os pacientes com LH que falham ao tratamento convencional de primeira linha. Os resultados em termos de sobrevidas livre de doença e global são superiores aos esquemas de salvamento com quimioterapia convencional. Este procedimento tem finalidade curativa para 50% dos pacientes em segunda remissão quimiossensíveis e pode levar a remissões duráveis naqueles com mais de duas linhas de terapia. Atualmente, o TCTH alogênico, basicamente com condicionamento de intensidade reduzida (RIC), está indicado em pacientes com recaída precoce após o TCTH autólogo ou em pacientes bastante jovens com refratariedade a mais de duas linhas de tratamento convencional. Abstract in english Hodgkin's Lymphoma is a hematologic malignancy with a wide range of therapeutic options that must be chosen according to the stage and the prognostic classification of each patient. The overall survival of patients treated for classic Hodgkin's Lymphoma is increasing significantly, with current cure [...] rates being between 80% and 85%. Nevertheless, 20% to 25% are refractory to the initial treatment and about 30% relapse after having reached a complete response. Patients that have failed standard therapy still have a second chance of cure if they present chemosensitivity to cure schemes, followed by one type of hematopoietic stem cell transplantation (TCTH). Autologous TCTH is an attractive strategy for Hodgkin's Lymphoma patients that fail in the conventional standard therapy. The results in terms of overall survival and disease-free survival are higher than the cure schemes with conventional chemotherapy. This procedure addresses the cure in 50% of chemosensitive patients in second remission, and can lead to lasting remissions for those with more than two lines of treatment. Today, allogeneic TCTH, basically with reduced intensity conditioning (RIC) is indicated for patients with premature relapse after autologous TCTH or for young patients refractory to one or more lines of conventional treatment.

Rosane I., Bittencourt; Laura, Fogliato; Alessandra, Paz; Mair P., Souza; Decio, Lerner.

2010-05-01

92

Linfoma hepático primario: causa infrecuente de lesión focal hepática  

Directory of Open Access Journals (Sweden)

de una punción biopsia ecoguiada informa una infiltración masiva por un linfoma B difuso de células grandes. La inmunohistoquímica es CD20+ , CD45+ con CD3, CKAE1, AE3, Hepatocyte y HMB45 negativos. La citología del líquido pleural es negativa para atipía, el frotis de sangre periférica descarta una leucemia, la biopsia de médula ósea es negativa para infitración linfomatosa y el centellograma con galio y la tomografía computada corporal pelvis no revelan lesiones extrahepáticas. La paciente inicia quimioterapia con ciclofosfamida y metilprednisona, pero empeora y fallece dos semanas después de iniciado el tratamiento. Concluimos que nuestra paciente tenía una enfermedad rara con una lesión irresecable, factores de mal pronóstico y alto riesgo de recurrencia. La quimioterapia es el tratamiento de elección en estos casos.

Carolina Balduzzi

2010-01-01

93

Hepatic angiosarcoma associated with disseminated intravascular coagulation.  

Science.gov (United States)

We present a case of hepatic angiosarcoma that presented with disseminated intravascular coagulopathy to highlight the difficulty in diagnosing this disease due its aggressive clinical course, the overlapping features of various coagulopathies, and the nonspecific appearance of angiosarcomas on imaging. PMID:25552799

Mazharuddin, Samir; Podduturi, Varsha; Guileyardo, Joseph M; Cooper, Barry

2015-01-01

94

Hepatic angiosarcoma associated with disseminated intravascular coagulation  

Science.gov (United States)

We present a case of hepatic angiosarcoma that presented with disseminated intravascular coagulopathy to highlight the difficulty in diagnosing this disease due its aggressive clinical course, the overlapping features of various coagulopathies, and the nonspecific appearance of angiosarcomas on imaging. PMID:25552799

Podduturi, Varsha; Guileyardo, Joseph M.; Cooper, Barry

2015-01-01

95

Disseminated intravascular coagulation: old disease, new hope  

OpenAIRE

Disseminated intravascular coagulation has long been associated with increased mortality in patients with sepsis. An effective treatment is now available, and the authors of this review describe how improved understanding and earlier diagnosis could lead to targeted treatment and improved prognosis

Toh, Cheng Hock; Dennis, Michael

2003-01-01

96

Ulcerative colitis complicated by disseminated intravascular coagulation.  

OpenAIRE

We report a case of chronic ulcerative colitis complicated by clinical evidence of disseminated intravascular coagulation and pathological evidence of intestinal ischaemia secondary to venular and capillary fibrin thrombi. This may well represent an example of univisceral Shwartzman reaction occurring in a sensitized target organ.

Muller, S.; Chesner, I. M.; Sheridan, J.; Newman, J.

1987-01-01

97

Linfoma B difuso de células grandes: factores pronósticos en la era del rituximab / Diffuse large B cell lymphoma: prognostic factors in the rituximab era  

Scientific Electronic Library Online (English)

Full Text Available SciELO Colombia | Language: Spanish Abstract in spanish Introducción: la inclusión del rituximab para el tratamiento del linfoma B difuso de células grandes generó la necesidad de reevaluar los factores pronósticos que se empleaban convencionalmente, y la de explorar otros que podrían resultar útiles para establecer el pronóstico. Objetivo: describir los [...] principales factores clínicos, hematológicos, bioquímicos e inmunohistoquímicos que han sido útiles para el pronóstico en estudios de seguimiento de pacientes con linfoma B difuso de células grandes tratados con esquemas de quimioterapia que contenían rituximab. Resultados: entre los factores con significancia para el pronóstico se encontraron el Índice Pronóstico Internacional (IPI) revisado, la infiltración de la médula ósea, la presencia de masa voluminosa, la expresión de CD5 y el porcentaje de expresión de Ki-67; en contraste, es controversial la aplicación de otros factores como el IPI convencional, la expresión de Bcl-2, Bcl-6 y el perfil inmunohistoquímico. Abstract in english Introduction: The inclusion of rituximab for treatment of diffuse large B cell lymphoma (DLBCL) generated the need to re-assess the conventionally employed prognostic factors and to explore others that could be useful for prognostic purposes. Objective: To describe the most important clinical, hemat [...] ological, biochemical and immunohistochemical factors that have been useful for prognostic purposes in follow-up studies of patients with DLBCL treated with chemotherapy plus rituximab. Results: The following factors were found to have prognostic significance: the revised International Prognostic Index, bone marrow infiltration, the presence of a bulky mass, CD5 expression and the percentage of Ki-67 expression. Contrariwise, the application of other factors remains controversial: conventional IPI, Bcl-2 and Bcl-6 expression, and the immunohistochemical profile.

Natalia María, Guevara Arismendy; Patricia Elena, Jaramillo Arbeláez; Lina María, Gaviria Jaramillo.

2013-07-01

98

Quilotórax bilateral y linfoma simultáneo en dos varones: presentación de dos casos / Bilateral chylothorax and simultaneous lymphoma in two male patients: report of two cases  

Scientific Electronic Library Online (English)

Full Text Available Fundamento: el quilotórax es una enfermedad grave, más aún si es bilateral y de causa maligna, pero tiene tratamiento y el enfermo puede estabilizarse. Objetivo: presentar dos pacientes de interés médico y demostrar que puede esperarse buena respuesta al tratamiento. Casos Clínicos: se presentaron d [...] os enfermos portadores de quilotórax bilateral y linfoma, ambos varones, atendidos en el hospital de forma simultánea; se realizaron los exámenes complementarios diagnósticos. El diagnóstico en ambos resultó linfoma no Hodgkin y Hodgkin respectivamente, fueron tratados con dieta, se restringieron las grasas; tratamiento oncoespecÍfico y toracocentésis repetidas en ambos hemitórax. El primero, mejorado del derrame bilateral y síntomas inicialmente, fallece a los 11 meses por no control de su enfermedad base. El segundo, estable de ambas afecciones a los 18 meses, en ambos casos el quilotórax se compensó y no fue necesario repetir drenaje. Se hacen análisis comparativo con otros reportes sobre todo cuando el linfoma es la causa etiológica, la conducta adoptada concuerda con otros estudios actuales. Conclusiones: los enfermos mejoraron del quilotórax bilateral, uno no estabilizó su enfermedad de base y murió, mientras el otro está asintomático. Puede obtenerse buena respuesta terapéutica. Abstract in english Background: chylothorax is a serious disease, even more if it is bilateral and of a malignant cause; but it has treatment and the patient’s condition may be stable. Objective: to present two patients of medical interest and prove that a good response from the treatment may be expected. Clinical case [...] s: two male patients with bilateral chylothorax and lymphoma were simultaneously attended at the hospital. Complementary diagnostic tests were made. The diagnosis of both patients turned out to be non-Hodgkin’s and Hodgkin’s lymphomas respectively. They were put on a diet in which fat was cut; the oncospecific treatment and repeated thoracocentesis were applied in both hemithoraxes. The first patient, after getting better from the bilateral effusion and initial symptoms, passed away 11 months later for not controlling the base disease. The second patient presented a stable condition of both complaints 18 months later. In both cases chylotorax was eased and it was not necessary to repeat the drainage. Analyses compared to other reports are made mainly when the lymphoma is the etiological cause; the adopted conduct coincides with other current studies. Conclusions: the patients got better from bilateral chylothorax; one of them did not get a stable condition of his base disease and died and the second one is asymptomatic. A good therapeutic response may be obtained.

Karina, Armas Moredo; Yamilet, Santos Herrera; Orlando E., Olivera Morán; Miguel Emilio, García Rodríguez; Bárbaro Agustín, Armas Pérez.

2014-02-01

99

Síndrome de vena cava superior: Una emergencia oncológica en niños con linfoma. Revisión de 5 casos / Superior Vena Cava Syndrome: an oncologic emergency in children with lymphoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Chile | Language: Spanish Abstract in spanish Introducción: Un niño con cáncer puede presentar durante su enfermedad una emergencia, ya sea como manifestación inicial, en la fase de diagnóstico, durante la evolución o en el periodo terminal. Objetivo: Presentar nuestra experiencia en el manejo del síndrome de Vena Cava Superior en niños con lin [...] foma. Pacientes y Método: Revisión retrospectiva de 44 fichas clínicas de menores de 15 años con linfoma tratados entre enero de 1989 y diciembre de 1999 en la Unidad de Hematología/Oncología Infantil del Hospital Clínico Regional de Valdivia. Resultados: 5 casos presentaron síndrome de Vena Cava Superior: Linfoma de Hodgkin 2. Linfoma no Hodgkin 3. El síndrome de Vena Cava Superior fue la manifestación inicial en 4. En la emergencia todos los pacientes recibieron corticoides y radioterapia. Tres pacientes se encuentran vivos y en remisión completa. Conclusiones: El síndrome de Vena Cava Superior, es poco frecuente en niños con patología tumoral, sin embargo, por constituir una emergencia médica requiere tratamiento inmediato, necesitándose claras pautas de manejo Abstract in english Introduction: A child with cancer may have an oncologic emergency during one of the following situations: A) Primary manifestation of the disease. B) Diagnostic phase. C) During clinical evolution of the disease. D) Terminal stage. Objective: To review our experience in the management of patients wi [...] th lymphoma presenting with Superior Vena Cava Syndrome (SVCS). Method: Retrospective analysis of clinical data of 44 patients younger than 15 years-old affected with lymphoma and treated at the Hemathology/Oncology Unit of the Clinical Hospital from Valdivia, between 1989 and 1999. Results: 5 patients presented SVCS; 2 of them had Hodgkin lymphoma and 3 had no-Hodgkin lymphoma. The SVCS was the first clinical manifestation in 4 of them. During the emergency, all patients were treated with steroids and radiotherapy, observing 3 of them still alive and free of disease. Conclusions: The SVCS is a rare complication in pediatric tumoral disease. It constitutes an oncologic emergency that we ought to know in terms of diagnosis and treatment

Miriam, Davis G.; Paola, Zolezzi R.; Nilda, Zumelzu D..

2005-10-01

100

Linfomas asociados a infección por VIH en pacientes del Hospital Clínico San Borja Arriarán / Fundación Arriarán2001-2008 / Lymphomas associated with HIV infection in patients at the Hospital San Borja Arriarán /Fundación Arriarán 2001-2008, Santiago, Chile  

Scientific Electronic Library Online (English)

Full Text Available SciELO Chile | Language: Spanish Abstract in spanish Introducción: Los linfomas de Hodgkin (LH) y no Hodgkin (LNH) se asocian con alta frecuencia al síndrome de inmunodeficiencia humana en adultos. Objetivo: Sistematizar los aspectos clínicos e histológicos de los linfoma que afectan a pacientes con SIDA, su tratamiento y resultados globales en nuestr [...] a institución. Pacientes y Métodos: Análisis retrospectivo de pacientes con linfoma asociado a VIH entre enero de 2001 y diciembre de 2008 en el complejo hospitalario San Borja Arriarán. Resultados: Se obtuvo información de 30 pacientes con LNH y 7 LH, con una mediana de 40 años. Los tipos histológicos predominantes fueron linfoma de Burkitt (47 %), linfoma difuso de células grandes de estirpe B (37 %) y LNH de estirpe T (10%). No se diagnosticaron LNH del SNC ni linfoma de cavidades. Casi la totalidad de los pacientes (86,7%) con LNH se trataron con esquema CHOP, 57% de quienes recibieron tratamiento presentaron progresión o recaída desde remisión completa, ofreciéndoles una quimioterapia de rescate a cuatro pacientes. El 73% de los pacientes que recibieron CHOP lograron completar entre cinco y seis ciclos de quimioterapia. El uso de quimioterapia CHOP para el subgrupo de pacientes con linfoma de Burkitt alcanzó bajos porcentajes de remisión completa y mayoritariamente progresó la enfermedad, siendo esta quimioterapia, inefectiva para mejorar la sobrevida, especialmente en los pacientes de riesgo alto. Se encontraron diferencias estadísticamente significativas en sobrevida según el IPIae (índice internacional pronóstico ajustado por edad) al ingreso. Conclusión: El LNH en los pacientes con VIH tratados con los protocolos de quimioterapia PANDA persiste en nuestro medio como una enfermedad de muy mal pronóstico comparado con los resultados en la literatura internacional. La incorporación de nuevos fármacos de demostrada utilidad como rituximab y esquemas específicos de quimioterapia podrían mejorar estos resultados. El establecimiento de grupos pronósticos establecidos por IPIae puede orientar el trabajo clínico para el uso de quimioterapia ajustada a su riesgo específico y optimizado según tipo histológico. Abstract in english Introduction: Hodgkin lymphomas (HL) and non Hodgkin lymphomas (NHL) are frequently associated to acquired immunodeficiency syndrome in adults. Objective: To systematize the clinical features and histological characteristics of lymphomas in AIDS patients, its treatment and outcomes in our institutio [...] n. Patients and Methods: Retrospective analysis of patients with HIV-associated lymphoma between January 2001 and December 2008 at the San Borja Arriarán Hospital complex. Results: Information was obtained from 30 patients with NHL and 7 with HL, with a median of 40 years. The majority of tumors were Burkitt lymphoma (47%), diffuse large cell lymphoma B-cell (37%) and NHL of T lineage (10%). There was no CNS or cavities lymphoma. Almost all patients (86.7%) with NHL were treated with CHOP chemotherapy, 57% of those receiving treatment had progression or relapse from complete remission. A rescue chemotherapy was indicated in 4 patients. 73% of patients receiving CHOP, complete 5 to 6 cycles of chemotherapy. The use of CHOP chemotherapy for the subgroup of patients with Burkitt lymphoma achieved low rates of complete remission and frequent relapse and disease progression, showing that CHOP was ineffective in improving survival, especially in high risk patients. We found statistically significant differences in survival according to IPIae (International prognostic Index age-adjusted). Conclusion: Non-Hodgkin lymphoma in HIV patients treated with chemotherapy protocols PAlNDA persists in our environment as a disease with a poor prognosis compared with findings in the international literature. The incorporation of new drugs of proven utility as rituximab and specific schemes chemotherapy could improve these results. The establishment of prognostic groups established by IPIae can guide clinical

Álvaro, Pizarro; Hernán, García; Ana, Riquelme; Javiera, Carmona; Claudia, Cortés.

2013-02-01

101

Linfoma renal: espectro de imagens na tomografia computadorizada Renal lymphoma: spectrum of computed tomography findings  

Directory of Open Access Journals (Sweden)

Full Text Available O acometimento renal no linfoma é raro, uma vez que o rim não possui tecido linfóide. O envolvimento secundário é mais freqüente, ocorrendo em até um terço das autópsias dos portadores de linfoma. Alguns autores acreditam que esta seja a única forma de acometimento renal, questionando a existência do linfoma primário. O linfoma renal representaria metástases hematogênicas ou invasão direta do tumor ocorrendo no espaço perirrenal. A partir destes tipos de envolvimento decorrem as formas de apresentação do linfoma renal: múltiplos nódulos, massa solitária, invasão renal por doença retroperitoneal contígua, doença perirrenal e infiltração difusa. Neste trabalho são discutidas e apresentadas imagens destas diferentes formas de acometimento.Isolated renal lymphoma is rare due to the absence of lymphoid tissue in kidneys. Secondary involvement occurs more frequently and is reported in up to 1/3 of the autopsies of patients who died from lymphoma. Some authors believe this is actually the only existing form of renal lymphoma. The involvement of the kidney by lymphoma would occur through hematogenic metastasis or direct tumor invasion of the perirenal space. These different types of involvement determine the several forms of renal lymphoma presentation: multiple nodules, solitary mass, renal invasion from contiguous retroperitoneal disease, perirenal disease and diffuse infiltration. In this study the imaging findings features of the different forms of involvement are presented and discussed.

Carol Pontes de Miranda Maranhão

2005-04-01

102

Linfoma renal: espectro de imagens na tomografia computadorizada / Renal lymphoma: spectrum of computed tomography findings  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese O acometimento renal no linfoma é raro, uma vez que o rim não possui tecido linfóide. O envolvimento secundário é mais freqüente, ocorrendo em até um terço das autópsias dos portadores de linfoma. Alguns autores acreditam que esta seja a única forma de acometimento renal, questionando a existência d [...] o linfoma primário. O linfoma renal representaria metástases hematogênicas ou invasão direta do tumor ocorrendo no espaço perirrenal. A partir destes tipos de envolvimento decorrem as formas de apresentação do linfoma renal: múltiplos nódulos, massa solitária, invasão renal por doença retroperitoneal contígua, doença perirrenal e infiltração difusa. Neste trabalho são discutidas e apresentadas imagens destas diferentes formas de acometimento. Abstract in english Isolated renal lymphoma is rare due to the absence of lymphoid tissue in kidneys. Secondary involvement occurs more frequently and is reported in up to 1/3 of the autopsies of patients who died from lymphoma. Some authors believe this is actually the only existing form of renal lymphoma. The involve [...] ment of the kidney by lymphoma would occur through hematogenic metastasis or direct tumor invasion of the perirenal space. These different types of involvement determine the several forms of renal lymphoma presentation: multiple nodules, solitary mass, renal invasion from contiguous retroperitoneal disease, perirenal disease and diffuse infiltration. In this study the imaging findings features of the different forms of involvement are presented and discussed.

Carol Pontes de Miranda, Maranhão; Tufik, Bauab Jr.

2005-04-01

103

Intravascular photoacoustic imaging of human coronary atherosclerosis  

Science.gov (United States)

We demonstrate intravascular photoacoustic imaging of human coronary atherosclerotic plaque. We specifically imaged lipid content, a key factor in vulnerable plaques that may lead to myocardial infarction. An integrated intravascular photoacoustics (IVPA) and ultrasound (IVUS) catheter with an outer diameter of 1.25 mm was developed. The catheter comprises an angle-polished optical fiber adjacent to a 30 MHz single-element transducer. The ultrasonic transducer was optically isolated to eliminate artifacts in the PA image. We performed measurements on a cylindrical vessel phantom and isolated point targets to demonstrate its imaging performance. Axial and lateral point spread function widths were 110 ?m and 550 ?m, respectively, for PA and 89 ?m and 420 ?m for US. We imaged two fresh human coronary arteries, showing different stages of disease, ex vivo. Specific photoacoustic imaging of lipid content, is achieved by spectroscopic imaging at different wavelengths between 1180 and 1230 nm.

Jansen, Krista; van der Steen, Antonius F. W.; Springeling, Geert; van Beusekom, Heleen M. M.; Oosterhuis, J. Wolter; van Soest, Gijs

2011-03-01

104

Techniques for Intravascular Foreign Body Retrieval  

International Nuclear Information System (INIS)

As endovascular therapies increase in frequency, the incidence of lost or embolized foreign bodies is increasing. The presence of an intravascular foreign body (IFB) is well recognized to have the potential to cause serious complications. IFB can embolize and impact critical sites such as the heart, with subsequent significant morbidity or mortality. Intravascular foreign bodies most commonly result from embolized central line fragments, but they can originate from many sources, both iatrogenic and noniatrogenic. The percutaneous approach in removing an IFB is widely perceived as the best way to retrieve endovascular foreign bodies. This minimally invasive approach has a high success rate with a low associated morbidity, and it avoids the complications related to open surgical approaches. We examined the characteristics, causes, and incidence of endovascular embolizations and reviewed the various described techniques that have been used to facilitate subsequent explantation of such materials

105

Intravascular papillary endothelial hyperplasia: report of two cases  

International Nuclear Information System (INIS)

Intravascular papillary endothelial hyperplasia is a rare benign vascular proliferative process as a result of papillary proliferation of the endothelial cells within the vascular lumen. We report two cases of intravascular papillary endothelial hyperplasia affecting the extremities. The characteristic sonological and MR imaging features are discussed, with updated review of literature. Imaging features are helpful in achieving a definitive diagnosis of the intravascular papillary endothelial hyperplasia

106

Intravascular papillary endothelial hyperplasia: report of two cases  

Energy Technology Data Exchange (ETDEWEB)

Intravascular papillary endothelial hyperplasia is a rare benign vascular proliferative process as a result of papillary proliferation of the endothelial cells within the vascular lumen. We report two cases of intravascular papillary endothelial hyperplasia affecting the extremities. The characteristic sonological and MR imaging features are discussed, with updated review of literature. Imaging features are helpful in achieving a definitive diagnosis of the intravascular papillary endothelial hyperplasia

Paunipagar, Bhawan K.; Rasalkar, Darshana D.; Ng, Alex; Griffith, James F. (Dept. of Imaging and Interventional Radiology, The Chinese Univ. of Hong Kong, Prince of Wales Hospital, Shatin, (Hong Kong)), email: darshana@cuhk.edu.hk; Bagaria, Vaibhav (Columbia Asia Hospital, Delhi (India))

2011-06-15

107

[Disseminated intravascular coagulation in solid tumours].  

Science.gov (United States)

Disseminated intravascular coagulation (DIC) is a complex abnormality of hemostasis with dramatic consequences and long described as associated with tumors. Yet the diagnosis and management of paraneoplastic DIC are poorly defined. The purpose of this paper is to review DIC associated with solid tumors, at the pathophysiological and therapeutic levels in particular. We also report data from a recent retrospective series of patients with DIC in the context of a solid tumor, to illustrate the epidemiological, clinical and prognostic. PMID:24977447

Ferrand, François Régis; Garcia-Hejl, Carine; Moussaid, Yassine; Schernberg, Antoine; Bidard, François-Clément; Pavic, Michel; Khenifer, Safia; Stoclin, Annabelle

2014-06-01

108

Automatic lumen segmentation from intravascular OCT images  

Science.gov (United States)

In the last decade intravascular optical coherence tomography has known a tremendous progress. Its high resolution (5- 10?m) allows coronary plaque characterization, vulnerable plaque assessment, and the guidance of intravascular interventions. However, one intravascular OCT sequence contains hundreds of frames, and their interpretation requires a lot of time and energy. Therefore, there is a strong need for automated segmentation algorithms to process this large amount of data. In this article, we present an automated algorithm to extract lumen contours from images obtained with intravascular Optical Coherence Tomography (OCT). Unlike existing methods, our algorithm requires no post- or preprocessing of the image. First, a sliding window is passed on every A-scan to locate the artery tissue, this location being determined from the largest distribution of the grey level values. Once all the tissue is extracted from the image, every segmented A-scan is binarized separately. For a single A-scan, the level of amplitude often varies strongly across the tissue. A global threshold would cause low amplitude parts of the tissue to be considered as belonging to the background. Our solution is to determine local thresholds for every A-scan. That is, instead of having a single global threshold, we allow the threshold itself to smoothly vary across the image. Subsequently, on the binarized image the Prewitt mask is moved from the detected tissue position toward the probe to segment the lumen. The proposed method has been validated qualitatively on images acquired under different conditions without changing any parameter of the algorithm. Experimental results show that the proposed method is accurate and robust to extract lumen borders.

Bourezak, Rafik; Lamouche, Guy; Cheriet, Farida

2010-03-01

109

Ventricular metastasis resulting in disseminated intravascular coagulation  

OpenAIRE

Abstract Background Disseminated Intravascular Coagulation (DIC) complicates up to 7% of malignancies, the commonest solid organ association being adenocarcinoma. Transitional Cell Carcinoma (TCC) has rarely been associated with DIC. Case presentation A 74-year-old woman with TCC bladder and DIC was found to have a cardiac lesion suspicious for metastatic disease. The DIC improved with infusion of plasma and administration of Vitamin K, however the cardiac lesion was deemed inoperable and che...

Davis Ian D; John Thomas

2005-01-01

110

Dapsone hypersensitivity syndrome causing disseminated intravascular coagulation  

OpenAIRE

Dapsone hypersensitivity syndrome is an idiosyncratic reaction to this drug and can present with different clinical manifestations of varying severity. We describe a patient with disseminated intravascular coagulation (DIC) as an adverse reaction to dapsone. To the best of our knowledge, this is the first time it has been described in the literature. She presented with fever, rash and abdominal pain; she also had marked eosinophilia and features suggestive of oxidative haemolysis. Her course ...

Figtree, Melanie Clare; Miyakis, Spiros; Tanaka, Kumiko; Martin, Linda; Konecny, Pam; Krilis, Steven

2009-01-01

111

Ophthalmic complications with disseminated intravascular coagulation.  

OpenAIRE

Massive lid oedema, ecchymosis, proptosis with a total restriction of extraocular movement, markedly raised intraocular pressure, and occlusion of the central retinal artery developed acutely in the right eye of a 26-year-old woman with a past history of disseminated intravascular coagulation. She had been admitted to hospital for symptoms of abdominal pain and bleeding from multiple sites a few hours earlier. Five days previously she had some proptosis of the other eye and had been treated w...

Patchett, R. B.; Wilson, W. B.; Ellis, P. P.

1988-01-01

112

Optimization of Stent Deployment by Intravascular Ultrasound  

OpenAIRE

Intravascular ultrasound (IVUS) is a useful diagnostic method that provides valuable information in addition to angiography regarding the coronary vessel lumen, dimensions, plaque burden, and characteristics. The major use of IVUS in coronary intervention is to guide interventional strategies and assess optimal stent deployment. Since the introduction of the drug-eluting stent (DES), concerns about restenosis have decreased. However, high-risk lesion subsets are being routinely treated with D...

Yoon, Hyuck-jun; Hur, Seung-ho

2012-01-01

113

Diagnosis and treatment of disseminated intravascular coagulation.  

Science.gov (United States)

Disseminated intravascular coagulation (DIC) is a condition in which systemic activation of coagulation without a specific localization occurs, resulting in extensive formation of intravascular fibrin, particularly in small and midsize vessels. Disseminated intravascular coagulation may lead to several altered coagulation parameters, including a low platelet count, abnormal global clotting assays, low levels of physiological anticoagulant proteases, or increased fibrin degradation products. Also, more complex assays for activation of coagulation factors or pathways may indicate involvement of these molecules in DIC. None of these tests alone, however, can accurately ascertain or rebuff a diagnosis of DIC. Nonetheless, a combination of readily available routine assays may be instrumental in establishing a diagnosis of DIC and can also be useful to point to a subset of patients with DIC that may need definite, often costly, interventions in the hemostatic system. Current insights on relevant etiological pathways that may contribute to the occurrence of DIC have led to innovative therapeutic and adjunctive approaches to patient with DIC. Management options directed at the amelioration of hemostatic activation may tentatively be indicated and were found to be advantageous in experimental and clinical investigations. These treatments encompass elimination of tissue factor-mediated thrombin generation or restitution of normal anticoagulant function. PMID:24750668

Levi, M

2014-06-01

114

Intravascular iodinated contrast media and the anaesthetist.  

Science.gov (United States)

The use of intravascular iodinated contrast media (ICM) in radiological investigations is common. Increasingly, anaesthetists and intensivists are involved in the care of patients undergoing these investigations. Whilst the use of ICM is generally safe there are important adverse effects that need to be recognised and measures instigated to prevent or treat these effects. In patients at risk of developing adverse reactions it is important to consider alternative modes of imaging so that ICM can be avoided. Strategies for the prevention of ICM nephropathy should be considered in all patients receiving ICM. Currently intravascular volume expansion with 0.9% saline has the strongest evidence base. The use of isotonic sodium bicarbonate combined with N-acetylcysteine appears promising in providing further benefits. Although the use of N-acetylcysteine alone has not been shown to significantly reduce the incidence of ICM nephropathy it is cheap, has few adverse effects and it would seem reasonable to continue its use in conjunction with intravascular volume expansion. The routine use of corticosteroid and antihistamine premedication is not always effective in preventing general adverse reactions. PMID:18477275

Dickinson, M C; Kam, P C A

2008-06-01

115

Reuso do efluente tratado na indústria curtidora  

Directory of Open Access Journals (Sweden)

Full Text Available Com o objetivo de avaliar a possibilidade de reúso do efluente líquido tratado de uma indústria curtidora, foi realizada esta pesquisa. O procedimento experimental comparou a produção de couros confeccionados com água potável, extraída de poçosartesianos, com couros produzidos a partir do efluente líquido final tratado. Para alcançar este objetivo, foram realizados testes físicose químicos através de análises em laboratório (análises químicas e de resistências físicas e avaliações organolépticas executadas porprofissionais do setor de couro (quanto a cor, firmeza de flor, enchimento e toque. A avaliação analítica e a das característicasorganolépticas não indicam diferenças representativas quando comparadas aos padrões de referência da ABNT de couros produzidos,permitindo, assim, concluir que o reúso de efluente tratado não altera a aparência dos artigos de couro.Abstract This research was carried out to evaluate the possibility of reuse of a tannery treated effluent. The experimental procedure compared the production of leather made by the use of drinking water, extracted from artesian wells, to leather produced by the use of the final treated liquid effluent. In order to achieve this goal, physic-chemical tests were carried out in laboratory (chemical and physical resistance analysis and leather industry professionals performed organoleptic evaluations (for color, grain firmness, filling and touch. The analytical evaluation and the organoleptic properties evaluation do not indicate a statistically significant difference when compared to ABNT reference standards of produced leathers, what allows the researchers to conclude that the reuse of treated effluent does not change the appearance of leather goods.

Karl Heinz Luersen

2012-01-01

116

Linfoma primário de cólon: relato de caso / Primary colorectal lymphoma: case report  

Scientific Electronic Library Online (English)

Full Text Available O linfoma colorretal primário é uma doença rara (0.2 a 0.6% de todas as neoplasias colônicas), apresentando pior prognóstico quando comparado com o linfoma gástrico primário ou com o adenocarcinoma do cólon. É uma doença com sintomatologia inespecífica, o que dificulta o diagnóstico precoce. O objet [...] ivo deste relato é mostrar um caso de linfoma primário do cólon, revisar critérios diagnósticos e tratamento. Abstract in english The primary colorectal lymphoma is a rare disease (0.2 to 0.6% of all colonic neoplasias), that has a worse prognosis than primary gastric lymphoma or colon adenocarcinoma. The poor signals makes the early diagnosis difficult. The objectives of this report is to describe a case of primary colon lymp [...] homa, revise diagnosis criteria and treatment.

Rafael Luís, Luporini; Antonio Carlos, Roma Júnior; Elaine Cristina Henrique, Almeida; Marcelo Rodolfo, Marciano; Luiz Vagner, Sipriani; Francisco de Assis, Gonçalves Filho; Alexandre Lopes de, Carvalho; Marcelo Maia Caixeta, Melo; Luís Sérgio, Ronchi; Geni Satomi, Cunrath; João Gomes, Netinho.

2010-09-01

117

MALT-linfoma de cérvix: reporte de caso  

Scientific Electronic Library Online (English)

Full Text Available Los linfomas MALT de cérvix son de muy rara presentación. Se reporta el caso de una paciente de 38 años con neoplasia linfoproliferativa detectada incidentalmente en los cortes de rutina, durante el estudio anátomo-patológico de espécimen de resección producto de histerectomía total, motivada por ha [...] llazgos ecográficos compatibles con miomatosis en cuerpo uterino. La etiología de esta neoplasia está asociada a procesos infecciosos o autoinmunes, se ha descrito alta radiosensibilidad y quimiosensibilidad a la biotera-pia contra anticuerpos CD20. Abstract in english The MALT-lymphomas of cervix are of very rare presentation. This is the case of a 38 years old patient in which this linfoproliferative disorder was detected incidentally in the routine cuts, during the anatomo-pathological study of a resection specimen product of total hysterectomy motivated by eco [...] graphic findings that were compatible with myomatosis of the uterine corpus. The etiology of these tumors is associated with infectious or autoimmune processes, and high radiosensitivity and chemosensitivity to biotherapy against antibodies CD20 (rituximab) has been described.

Inés, Benedetti P; Lía, Barrios G; Eusebio, Contreras B.

118

MALT-linfoma de cérvix: reporte de caso  

Directory of Open Access Journals (Sweden)

Full Text Available Los linfomas MALT de cérvix son de muy rara presentación. Se reporta el caso de una paciente de 38 años con neoplasia linfoproliferativa detectada incidentalmente en los cortes de rutina, durante el estudio anátomo-patológico de espécimen de resección producto de histerectomía total, motivada por hallazgos ecográficos compatibles con miomatosis en cuerpo uterino. La etiología de esta neoplasia está asociada a procesos infecciosos o autoinmunes, se ha descrito alta radiosensibilidad y quimiosensibilidad a la biotera-pia contra anticuerpos CD20.The MALT-lymphomas of cervix are of very rare presentation. This is the case of a 38 years old patient in which this linfoproliferative disorder was detected incidentally in the routine cuts, during the anatomo-pathological study of a resection specimen product of total hysterectomy motivated by ecographic findings that were compatible with myomatosis of the uterine corpus. The etiology of these tumors is associated with infectious or autoimmune processes, and high radiosensitivity and chemosensitivity to biotherapy against antibodies CD20 (rituximab has been described.

Inés Benedetti P

2012-01-01

119

Hypothesis: Disseminated Intravascular Inflammation as the Inflammatory Counterpart to Disseminated Intravascular Coagulation  

Science.gov (United States)

We have identified a leukocyte activation syndrome that is occasionally associated with the transfusion of intraoperatively recovered erythrocytes. This syndrome appears to result from intravascular damage caused by leukocytes activated during the erythrocyte salvage process. We hypothesize that this syndrome is part of a larger disease grouping: disseminated intravascular inflammation (DII). DII is the analog of the coagulation disorder disseminated intravascular coagulation. In disseminated intravascular coagulation, the organ damage results from uncontrolled activation of the clotting pathway; in DII the damage is caused by leukocytes that have become activated by direct contact with bacteria or in rare instances-such as erythrocyte salvage-in the absence of bacteria and bacterial products. Recent studies of the hazards associated with intraoperative blood salvage indicate that activation of leukocytes can be achieved by exposure to activated platelets alone. If such activated leukocytes are reinfused along with the washed erythrocytes, widespread organ damage may result. The lung is the organ most severely affected by activated leukocytes. Adult respiratory distress syndrome is one outcome. It is likely that DII is a presently unrecognized pathophysiological process that complicates a variety of primary disease states and increases their lethality.

Bull, Brian S.; Bull, Maureen H.

1994-08-01

120

Recurrent Disseminated Intravascular Coagulation Caused by Intermittent Dosing of Rifampin  

OpenAIRE

Daily rifampin therapy is associated with minimal adverse effects, but administration on an intermittent or interrupted basis has been associated with severe immunoallergic reactions such as hemolytic anemia, acute renal failure, and disseminated intravascular coagulation. We describe a patient with Mycobacterium leprae infection who experienced recurrent episodes of disseminated intravascular coagulation after intermittent exposures to rifampin, and review eight previously reported cases of ...

Havey, Thomas C.; Cserti-gazdewich, Christine; Sholzberg, Michelle; Keystone, Jay S.; Gold, Wayne L.

2012-01-01

121

Disseminated Intravascular Coagulation and Death Due to Snake Bites  

OpenAIRE

Disseminated intravascular coagulation is a serious and life threatening systemic complication of snake bites that can cause death if the treatment is delayed. Herein we present a 57-year-old female patient with no prior systemic disease who died because of disseminated intravascular coagulation that developed in 6 hours due to a snake bite.

Yavuz Orak; Tunga Barç?n; Sevgi Akbulut; Bilal Ba?analan; Filiz Orak

2012-01-01

122

Disseminated Intravascular Coagulation and Death Due to Snake Bites  

Directory of Open Access Journals (Sweden)

Full Text Available Disseminated intravascular coagulation is a serious and life threatening systemic complication of snake bites that can cause death if the treatment is delayed. Herein we present a 57-year-old female patient with no prior systemic disease who died because of disseminated intravascular coagulation that developed in 6 hours due to a snake bite.

Yavuz Orak

2012-04-01

123

The Potential and Limitations of Intravascular Optical Coherence Tomography  

Directory of Open Access Journals (Sweden)

Full Text Available There has been analyzed the experience gained on optical coherence tomography (OCT application for diagnosis and control of arterial sclerotic disease. The principles of OCT-images acquisition have been described; there have been assessed the advantages and disadvantages of intravascular OCT devices used in clinical practice; and safety and the capabilities of intravascular OCT-procedure have been discussed. Great potential of intravascular OCT for understanding and management of arterial sclerotic disease has been demonstrated. There have been considered the possibilities of life-time diagnostics of a “vulnerable” atherosclerosis plaque, the determination of calcium and macrophages content in atherosclerosis plaque, as well as the features of coronarothrombosis. There has been brought to a sharper focus the role of intravascular OCT in stenting monitoring. The ways of improvement of intravascular OCT and its further development prospects have been presented.

N.D. Gladkova

2012-12-01

124

Multi-frequency intravascular ultrasound (IVUS) imaging.  

Science.gov (United States)

Acute coronary syndrome (ACS) is frequently associated with the sudden rupture of a vulnerable atherosclerotic plaque within the coronary artery. Several unique physiological features, including a thin fibrous cap accompanied by a necrotic lipid core, are the targeted indicators for identifying the vulnerable plaques. Intravascular ultrasound (IVUS), a catheter-based imaging technology, has been routinely performed in clinics for more than 20 years to describe the morphology of the coronary artery and guide percutaneous coronary interventions. However, conventional IVUS cannot facilitate the risk assessment of ACS because of its intrinsic limitations, such as insufficient resolution. Renovation of the IVUS technology is essentially needed to overcome the limitations and enhance the coronary artery characterization. In this paper, a multi-frequency intravascular ultrasound (IVUS) imaging system was developed by incorporating a higher frequency IVUS transducer (80 to 150 MHz) with the conventional IVUS (30-50 MHz) system. The newly developed system maintains the advantage of deeply penetrating imaging with the conventional IVUS, while offering an improved higher resolution image with IVUS at a higher frequency. The prototyped multifrequency catheter has a clinically compatible size of 0.95 mm and a favorable capability of automated image co-registration. In vitro human coronary artery imaging has demonstrated the feasibility and superiority of the multi-frequency IVUS imaging system to deliver a more comprehensive visualization of the coronary artery. This ultrasonic-only intravascular imaging technique, based on a moderate refinement of the conventional IVUS system, is not only cost-effective from the perspective of manufacturing and clinical practice, but also holds the promise of future translation into clinical benefits. PMID:25585394

Ma, Teng; Yu, Mingyue; Chen, Zeyu; Fei, Chunlong; Shung, K Kirk; Zhou, Qifa

2015-01-01

125

Positron autoradiography for intravascular imaging: feasibility evaluation  

International Nuclear Information System (INIS)

Approximately 70% of acute coronary artery disease is caused by unstable (vulnerable) plaques with an inflammation of the overlying cap and high lipid content. A rupturing of the inflamed cap of the plaque results in propagation of the thrombus into the lumen, blockage of the artery and acute ischaemic syndrome or sudden death. Morphological imaging such as angiography or intravascular ultrasound cannot determine inflammation status of the plaque. A radiotracer such as 18F-FDG is accumulated in vulnerable plaques due to higher metabolic activity of the inflamed cap and could be used to detect a vulnerable plaque. However, positron emission tomography (PET) cannot detect the FDG-labelled plaques because of respiratory and heart motions, small size and low activity of the plaques. Plaques can be detected using a miniature particle (positron) detector inserted into the artery. In this work, a new detector concept is investigated for intravascular imaging of the plaques. The detector consists of a storage phosphor tip bound to the end of an intravascular catheter. It can be inserted into an artery, absorb the 18F-FDG positrons from the plaques, withdrawn from the artery and read out. Length and diameter of the storage phosphor tip can be matched to the length and the diameter of the artery. Monte Carlo simulations and experimental evaluations of coronary plaque imaging with the proposed detector were performed. It was shown that the sensitivity of the storage phosphor dethe sensitivity of the storage phosphor detector to the positrons of 18F-FDG is sufficient to detect coronary plaques with 1 mm and 2 mm sizes and 590 Bq and 1180 Bq activities in the arteries with 2 mm and 3 mm diameters, respectively. An experimental study was performed using plastic tubes with 2 mm diameter filled with an FDG solution, which simulates blood. FDG spots simulating plaques were placed over the surface of the tube. A phosphor tip was inserted into the tube and imaged the plaques. Exposure time was 1 min in all simulations and experiments. Experiments showed that detecting the coronary plaques using the proposed technique is possible. The proposed technique has the potential for fast and accurate detection of vulnerable coronary and other intravascular plaques

126

Positron autoradiography for intravascular imaging: feasibility evaluation  

Science.gov (United States)

Approximately 70% of acute coronary artery disease is caused by unstable (vulnerable) plaques with an inflammation of the overlying cap and high lipid content. A rupturing of the inflamed cap of the plaque results in propagation of the thrombus into the lumen, blockage of the artery and acute ischaemic syndrome or sudden death. Morphological imaging such as angiography or intravascular ultrasound cannot determine inflammation status of the plaque. A radiotracer such as 18F-FDG is accumulated in vulnerable plaques due to higher metabolic activity of the inflamed cap and could be used to detect a vulnerable plaque. However, positron emission tomography (PET) cannot detect the FDG-labelled plaques because of respiratory and heart motions, small size and low activity of the plaques. Plaques can be detected using a miniature particle (positron) detector inserted into the artery. In this work, a new detector concept is investigated for intravascular imaging of the plaques. The detector consists of a storage phosphor tip bound to the end of an intravascular catheter. It can be inserted into an artery, absorb the 18F-FDG positrons from the plaques, withdrawn from the artery and read out. Length and diameter of the storage phosphor tip can be matched to the length and the diameter of the artery. Monte Carlo simulations and experimental evaluations of coronary plaque imaging with the proposed detector were performed. It was shown that the sensitivity of the storage phosphor detector to the positrons of 18F-FDG is sufficient to detect coronary plaques with 1 mm and 2 mm sizes and 590 Bq and 1180 Bq activities in the arteries with 2 mm and 3 mm diameters, respectively. An experimental study was performed using plastic tubes with 2 mm diameter filled with an FDG solution, which simulates blood. FDG spots simulating plaques were placed over the surface of the tube. A phosphor tip was inserted into the tube and imaged the plaques. Exposure time was 1 min in all simulations and experiments. Experiments showed that detecting the coronary plaques using the proposed technique is possible. The proposed technique has the potential for fast and accurate detection of vulnerable coronary and other intravascular plaques.

Shikhaliev, Polad M.; Xu, Tong; Ducote, Justin L.; Easwaramoorthy, Balasubramaniam; Mukherjee, Jogeshwar; Molloi, Sabee

2006-02-01

127

Positron autoradiography for intravascular imaging: feasibility evaluation  

Energy Technology Data Exchange (ETDEWEB)

Approximately 70% of acute coronary artery disease is caused by unstable (vulnerable) plaques with an inflammation of the overlying cap and high lipid content. A rupturing of the inflamed cap of the plaque results in propagation of the thrombus into the lumen, blockage of the artery and acute ischaemic syndrome or sudden death. Morphological imaging such as angiography or intravascular ultrasound cannot determine inflammation status of the plaque. A radiotracer such as 18F-FDG is accumulated in vulnerable plaques due to higher metabolic activity of the inflamed cap and could be used to detect a vulnerable plaque. However, positron emission tomography (PET) cannot detect the FDG-labelled plaques because of respiratory and heart motions, small size and low activity of the plaques. Plaques can be detected using a miniature particle (positron) detector inserted into the artery. In this work, a new detector concept is investigated for intravascular imaging of the plaques. The detector consists of a storage phosphor tip bound to the end of an intravascular catheter. It can be inserted into an artery, absorb the 18F-FDG positrons from the plaques, withdrawn from the artery and read out. Length and diameter of the storage phosphor tip can be matched to the length and the diameter of the artery. Monte Carlo simulations and experimental evaluations of coronary plaque imaging with the proposed detector were performed. It was shown that the sensitivity of the storage phosphor detector to the positrons of 18F-FDG is sufficient to detect coronary plaques with 1 mm and 2 mm sizes and 590 Bq and 1180 Bq activities in the arteries with 2 mm and 3 mm diameters, respectively. An experimental study was performed using plastic tubes with 2 mm diameter filled with an FDG solution, which simulates blood. FDG spots simulating plaques were placed over the surface of the tube. A phosphor tip was inserted into the tube and imaged the plaques. Exposure time was 1 min in all simulations and experiments. Experiments showed that detecting the coronary plaques using the proposed technique is possible. The proposed technique has the potential for fast and accurate detection of vulnerable coronary and other intravascular plaques.

Shikhaliev, Polad M [Department of Radiological Sciences, University of California at Irvine, Irvine, CA 92697 (United States); Xu, Tong [Department of Radiological Sciences, University of California at Irvine, Irvine, CA 92697 (United States); Ducote, Justin L [Department of Radiological Sciences, University of California at Irvine, Irvine, CA 92697 (United States); Easwaramoorthy, Balasubramaniam [Department of Psychiatry and Human Behavior, University of California at Irvine, Irvine, CA 92697 (United States); Mukherjee, Jogeshwar [Department of Psychiatry and Human Behavior, University of California at Irvine, Irvine, CA 92697 (United States); Molloi, Sabee [Department of Radiological Sciences, University of California at Irvine, Irvine, CA 92697 (United States)

2006-02-21

128

Pulmonary intravascular hemangiosarcoma in a cat  

International Nuclear Information System (INIS)

A 9-year-old, castrated male Japanese domestic cat presented with a complaint of exertional dyspnea. Based on the radiographic findings, presumptive diagnosis of aspiration pneumonia or primary diffuse pulmonary neoplasia in the right middle lobe was made. Histologically, the pulmonary lesion was characterized by diffuse thickening of alveolar wall with the proliferation of apparently atypical irregular-shaped cells. Immunohistochemical staining using anti-human factor VIII-related antigen antiserum showed positive reaction in the cytoplasm of the atypical cells. According to the findings, the lesion was diagnosed as pulmonary intravascular hemangiosarcoma

129

Anemia hemolítica autoinmune como manifestación inicial de linfoma hodgkin  

Scientific Electronic Library Online (English)

Full Text Available Se presenta el caso de una paciente de 66 años de edad, a la que se le diagnostica anemia hemolítica, la cual fue refractaria al tratamiento y requirió esplenectomía. Además presenta adenomegalias inguinales, cuya biopsia determina infiltración parcial por células linfoides B CD20+, con atipia, y CD [...] 30+, con factor de proliferación alto; en médula ósea se constata incremento de linfocitos T. Cuatro meses después, consulta por la aparición de adenopatías inguinales y axilares, de las cuales la biopsia reveló enfermedad de Hodgkin variante esclerosis nodular, y en médula ósea se evidenció infiltración por la enfermedad linfoproliferativa. Si bien es infrecuente la asociación entre anemia hemolítica y linfoma Hodgkin, debe tenerse en cuenta para llegar a la búsqueda oportuna de su causa y al diagnóstico de un probable proceso linfoproliferativo subyacente. Abstract in english In this work we report and study a case of 66 year old woman, whit diagnosis of hemolytic anemia, which was refractory to treatment and she required splenectomy. The patient presented inguinal lymphadenopathy which biopsy has determined a partial infiltration of B-cells CD20 + and CD30 + with atypia [...] and high growth factor. The bone marrow biopsy informed an increased number of T lymphocytes. Four month later, the patient complained due to the appearance of inguinal and axillaries lymph nodes, which biopsy revealed a nodular sclerosis Hodgkin lymphoma. The bone marrow biopsy showed infiltration by lymphoproliferative disease. Although the association between hemolytic anemia and Hodgkin lymphoma is less frequent, this fact should be taken into account in searching its cause and reaching the diagnosis of a probable underlying lymphoproliferative process.

María Virginia, Bürgesser; Diego, Camps; Ana, Diller; Gastón, Caeiro.

2011-03-01

130

Linfoma gástrico tipo malt presentación de un caso  

Scientific Electronic Library Online (English)

Full Text Available Paciente femenina, raza blanca, de 50 años de edad, que acudió a consulta de gastroenterología de la clínica Popular „Simón Bolívar‰ remitida de su área de salud, por presentar dolor abdominal de tipo epigastralgias, de moderada intensidad, de 2 meses de evolución, con sensación de ardor, además de [...] aparecer más recientemente náuseas y vómitos post-prandiales. La endoscopia superior evidenció lesiones nodulares del fondo y ulcerada del cardias, el estudio histopatológico con inmunohistoquímica reveló linfoma no Hodgkin de células B extranodal, del tejido linfoide asociado a mucosa (MALTOMA). Cumplió tratamiento erradicador para el Helicobacter pylori. Las endoscopias evolutivas mostraron evidente mejoría. Catorce meses después, la evaluación histopatológica reportó gastritis crónica atrófica sin atipias, ausencia de infección por Helicobacter pylori. Actualmente está asintomática y tiene seguimiento semestral. Abstract in english Female patient, Caucasian, 50 years old, who turned up for Gastroenterology consult of the „Simon Bolivar‰Popular Clinic, remitted from their health area , because of epigastric abdominal pain of moderate intensity with two months of evolution, with burning sensation, besides nauseas and vomiting. T [...] he upper digestive endoscopy showed a big ulceration in the cardial portion and granulate mucosa in the bottom of stomach. The histological study with inmunohistochemistry revealed a B extranodal cell non Hodgkin lymphoma of mucosa-associated lymphoid tissue (MALT). She completed treatment for eradication of Helicobacter pylori . Fourteen months later, the histopathologic evaluation reported a chronic atrophic gastritis without atypical cells and an absence of infection for Helicobacter pylori. At the moment she is asymptomatic and has a biannual follow-up.

Alfonso, Norlan de la Cruz; Zuleyma Carolina, De Jesús; Caridad, Kindelán Medina.

2008-03-01

131

Linfoma gástrico MALT de alto grado: A propósito de un caso  

Scientific Electronic Library Online (English)

Full Text Available El Linfoma MALT o también llamado Maltoma es una entidad clínica bien conocida descrita como un tipo de respuesta inmune basada en la interconexión de órganos mucosos distantes entre sí. Dicha entidad se ha relacionado claramente con la infección por H. pylori como ente bacteriano que estimula la re [...] spuesta inmunológica, corroborándose tal causalidad al erradicarse la bacteria y observar la regresión del tumor en su totalidad. A continuación presentamos el caso de masculino de 76 años a quien se le diagnóstica un Linfoma MALT de alto grado y posterior a recibir tratamiento se logra la regresión total del tumor, el cual bajo un seguimiento estricto a lo largo de 10 años se mantiene asintomático. Abstract in english Linfoma MALT or also Maltoma call is a clinical organization described well-known good like a type of immune response based on the interconnection of distant mucous organs to each other. This organization has been related clearly to the infection by H. pylori like bacterial being that stimulates the [...] immunological answer, corroborating such causality when eradicating itself the bacterium and to observe the regression of the tumor in its totality. Next we presented/displayed the case of masculine of 76 years to that diagnostic him a Linfoma MALT of high later degree and to be received treatment is obtained the total regression of the tumor, which under a strict pursuit throughout 10 years stays asintomatic.

Gerardo, Casanova; Sirlene, Ramírez; Regulo, Ochoa; Jhoanny, Pereira.

2006-06-01

132

Linfoma primario de hueso con afectación multicéntrica / Primary bone lymphoma with multicentric involvement  

Scientific Electronic Library Online (English)

Full Text Available SciELO Argentina | Language: Spanish Abstract in spanish El linfoma primario de hueso es una enfermedad infrecuente, que tiene una presentación y evolución diferente a los linfomas de otras localizaciones. Se presenta un caso de linfoma primario de hueso de localización craneana y esternal de rápido crecimiento. En su evolución, realizada la exéresis de l [...] a lesión primaria de calota, presentó aparición de nuevas lesiones de rápido crecimiento a nivel craneano y fémur y progresión de lesión preesternal que, con anatomía patológica de linfoma no Hodgkin difuso de células grandes B, inició R-CHOPP (ciclofosfamida, doxorrubicina, vincristina, prednisona y rituximab) con rápida disminución de todas las lesiones sin evidencia de progresión al cabo de los seis ciclos. Abstract in english Primary bone lymphoma is a rare disease, which usually has a different presentation and evolution than lymphomas of other locations. We are presenting a case of primary bone lymphoma of rapid growth, in cranial and sternal locations. In its evolution, once the excision of the primary lesion of the s [...] kull was performed, the patient presented new lesions of rapid growth at the skull and femur level, and progression of pre-sternal lesion. With large B-cell diffuse non-Hodgkin lymphoma pathology, the patient initiated R-CHOPP (cyclophosphamide, doxorubicin, vincristine, prednisone and rituximab) with rapid reduction of all lesions without evidence of progression after the six cycles.

Marcelo, Graziadio; Natalia, Medina; Marcelo, Amato; María del Carmen, Ardaiz; Santiago, Ilutovich; Marcelo, Torino.

2012-10-01

133

Linfoma B difuso de células grandes en ovario: presentación de un caso  

Scientific Electronic Library Online (English)

Full Text Available SciELO Chile | Language: Spanish Abstract in spanish El linfoma B difuso de células grandes es un linfoma no Hodgkin de fenotipo B y gran agresividad, con una diseminación a ovario del 7%. Su presentación de forma primaria en ovario es muy poco común, representando el 0,5% de todos los linfomas no Hodgkin y el 1,5% de todos los tumores de ovario. En e [...] ste caso se presenta una paciente con clínica de dolor y distensión abdominal con una masa pélvica palpable, estableciéndose posteriormente el diagnóstico de linfoma B difuso de células grandes bilateral de ovario. En determinadas situaciones resulta complicado diferenciar el origen primario o secundario de la neoplasia. Los linfomas primarios localizados en ovario tienen un mejor pronóstico que los secundarios diseminados a ovario cuyo pronóstico es más sombrío. Sin embargo la mayoría de los casos publicados están basados en tratamiento quimioterápico previo a la era de rituximab. Abstract in english The diffuse large B-cell lymphoma is a highly aggressive phenotype B non-Hodgkin lymphoma which is characterized by 7% dissemination in the ovary. Its presentation in primary form in the ovary is very uncommon and accounts for 0.5% of all lymphomas. In this case, the patient presents symptoms of pai [...] n and abdominal strain with a palpable pelvic mass and a post-diagnosis of bilateral diffuse large B-cell lymphoma in the ovary. In certain situations, it is complicated to differentiate between the primary and secondary origin of the neoplasia. The primary lymphomas located in the ovary have a better prognosis than secondary lymphomas whose prognosis is more uncertain. However, the majority of published cases are subjected to chemothe-rapeutic treatment prior to rituximab.

Mariam, Abulhaj Martínez; Nicolás, Alayón Hernández; Rafael, Sotelo Avilés; Encarnación, Arévalo Reyes; Mercedes, Caba Molina; Mercedes, Gómez Morales.

134

Linfoma T subcutâneo do tipo paniculite: relato de um caso acometendo paciente pediátrico Subcutaneous panniculitic T cell lymphoma: a case report affecting a child  

OpenAIRE

Os autores relatam um caso de linfoma T subcutâneo do tipo paniculite em uma paciente feminina de 3 anos, apresentando havia um mês múltiplos nódulos subcutâneos, indolores, disseminados no abdome, região peitoral e cervical. Ao exame histopatológico, evidenciou-se um linfoma T infiltrando tecido adiposo subcutâneo. Os linfomas T subcutâneos representam uma entidade clinicopatológica distinta, sendo raro o acometimento pediátrico.We report a case of lypotrophic lymphoma affecting a...

Lúcia Noronha; Fabiola Medeiros; Luciano Monte Serrat Prevedello; Vanessa Dello Monaco Martins; Flora Watanabe; José Fillus Neto

2001-01-01

135

Disseminated intravascular coagulation or extended intravascular coagulation in massive pulmonary embolism  

OpenAIRE

See also Leitner JM, Jilma B, Spiel AO, Sterz F, Laggner AN, Janata KM. Massive pulmonary embolism leading to cardiac arrest is associated with consumptive coagulopathy presenting as disseminated intravascular coagulation. This issue, pp 1477–82; Thachil J. DIC score predicts mortality in massive clot coagulopathy as a result of extensive pulmonary embolism: a rebuttal. This issue, pp 1657–8; Leitner JM, Janata-Schwatzek K, Spiel AO, Sterz F, Laggner AN, Jilma B. DIC score predicts mortal...

Levi, M.

2010-01-01

136

Asociación entre hepatitis crónica por virus C y linfoma no Hodgkin de células B / Association between chronic hepatitis C virus infection and non-Hodgkin B cell lymphoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Se estima que unos 170 millones de personas están infectadas por el virus de la hepatitis C (VHC) en todo el mundo. La persistencia del virus en el organismo es consecuencia de su capacidad de mutar y de las alteraciones en la respuesta inmunológica que produce. Existen teorías que relacionan este v [...] irus con la linfomagénesis. El riesgo relativo de que pacientes infectados con el VHC padezcan linfoma no Hodgkin (LNH) es de 2 a 4 veces mayor que en los sujetos no infectados. Esta asociación tiene variabilidad geográfica: los países donde esa asociación es mayor son Italia, Japón y Estados Unidos, y donde es menor son Canadá y los del norte de Europa. El linfoma de la zona marginal de células B y el linfoplasmocitico son los más reportados en asociación con el VHC. Los LNH indolentes asociados con el VHC pueden ser tratados con terapia antiviral, no así las formas agresivas que necesitan de inmunoquimioterapia específica. Se ha demostrado que la hepatitis C es un significativo factor de riesgo para la toxicidad hepática en los pacientes que necesitan quimioterapia. Abstract in english 170 million people are estimated to be infected with hepatitis C virus (HCV) worldwide. The persistence of the virus in the body is due to its ability to mutate and alterations in the immune response that occurs. There are theories linking this virus lymphoma genesis. The relative risk of HCV-infect [...] ed patients suffering from non-Hodgkin lymphoma is 2-4 times higher than in uninfected subjects. This association has geographic variability. Countries where the association is stronger are Italy, Japan, and the United States, and it is lesser in Canada and northern Europe. Lymphoma of the marginal zone in B cells and lymphoplasmacytic are the most well-informed in association with HCV. Indolent non-Hodgkin lymphomas associated with HCV can be treated with antiviral therapy, but the aggressive forms require specific immunochemotherapy. Hepatitis C has been shown to be a significant risk factor for hepatic toxicity in patients needing chemotherapy.

Zaily, Dorta Guridi; Enrique Rogelio, Arús Soler; Luis, Calzadilla Bertot.

2014-12-01

137

Death following intravascular administration of contrast media  

International Nuclear Information System (INIS)

Adverse reactions to intravascularly administered contrast media preceding death and the autopsy findings in 44 patients are presented. There is a wide scatter of the age distribution of fatal reactions. The highest incidence is in the 50-70 year age group. Similar observations were obtained from the 405 deaths due to contrast media reported to the Food and Drug Administration of the United States. In the same age group the number of reactions is highest, likewise the autopsy findings. The predominant autopsy findings are pulmonary edema, congestion and hemorrhage; arteriosclerosis, both general and coronary. In the younger age group the autopsy findings are limited mostly to the respiratory tract. Fatal reactions to contrast media occur often without warning and most deaths occur within 15 min to 6 hours. Reactions to contrast media occur without relation to sex or age. (orig.)

138

Prostate cancer: beware of disseminated intravascular coagulation.  

Science.gov (United States)

Disseminated intravascular coagulation (DIC) is a pathological systemic condition resulting from aberrant activation of the coagulation system. It is characterised by the release and activation of procoagulants into the blood, with an associated consumption coagulopathy. Its association with solid and haematological malignancies is well described in literature. This case describes an elderly man, known to have prostate cancer, who following transurethral resection of the prostate developed DIC with haematuria, spontaneous ecchymoses and mucosal bleeding. Subsequent investigations revealed a prostate-specific antigen (PSA) >1000?µg/L, and staging CT showed multiple sclerotic metastatic lesions affecting the thoracic and lumbar vertebra, as well as infiltration into his left femur. Coagulation normalised with blood products and vitamin K within 1?week, and the patient responded to antiandrogen therapy with a reduction in pain and PSA on discharge. PMID:25819815

Desai, Mihir; John, Babbin; Evans, Gillian; Eddy, Ben

2015-01-01

139

Ventricular metastasis resulting in disseminated intravascular coagulation  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Disseminated Intravascular Coagulation (DIC complicates up to 7% of malignancies, the commonest solid organ association being adenocarcinoma. Transitional Cell Carcinoma (TCC has rarely been associated with DIC. Case presentation A 74-year-old woman with TCC bladder and DIC was found to have a cardiac lesion suspicious for metastatic disease. The DIC improved with infusion of plasma and administration of Vitamin K, however the cardiac lesion was deemed inoperable and chemotherapy inappropriate; given the patients functional status. We postulate that direct activation of the coagulation cascade by the intraventricular metastasis probably triggered the coagulopathy in this patient. Conclusion Cardiac metastases should be considered in cancer patients with otherwise unexplained DIC. This may influence treatment choices.

Davis Ian D

2005-05-01

140

Características epidemiológicas, clínicas y patológicas de los linfomas en el Hospital Nacional Cayetano Heredia del año 1998 al 2008 / Epidemiological, clinical, and pathologic characteristics of lymphoma cases in Cayetano Heredia National Hospital from 1998 to 2008  

Scientific Electronic Library Online (English)

Full Text Available SciELO Peru | Language: Spanish Abstract in spanish Objetivo: Conocer las características epidemiológicas, clínicas y patológicas de los pacientes con linfoma diagnosticados en el Hospital Nacional Cayetano Heredia. Material y métodos: Se realizó un estudio descriptivo, retrospectivo, tipo serie de casos de 433 pacientes portadores de linfoma del año [...] 1998 al 2008. Resultados: El promedio de edad fue de 44,8 años, 60,04% eran de sexo masculino. El lugar de nacimiento y procedencia más frecuente fue Lima con 61,5% y 90% respectivamente. Los síntomas más frecuentes son la baja de peso y la presencia de linfoadenopatías (40,5% y 3,7% respectivamente). El 55,08% de los pacientes se encontraban en estadio clínico I - II. La localización más frecuente fue ganglionar (55,1%). Las localizaciones extraganglionares más frecuentes fueron: gastrointestinal (15,2%) y piel (10,8%). Se hallo que el inmunofenotipo B fue de 57.8% de los linfoma no Hodgkin y el patrón histológico más común fue el linfoma de células grandes difuso (35,8%), enfermedad de Hodgkin fue el 14,08%. De los pacientes tratados, 78,12% tuvieron respuesta completa y parcial de la enfermedad. El tratamiento en la enfermedad de Hodgkin fue ABVD con 90,97% de respuesta completa y parcial. Solo se reportó que el 23,45% de los pacientes han fallecido al momento. Conclusiones: Los pacientes con linfoma atendidos en el Hospital Nacional Cayetano Heredia tienen características similares a lo reportado a nivel mundial. Abstract in english Objective: To determine the epidemiological, clinical and pathological characteristics of lymphoma cases in Cayetano Heredia National Hospital. Material and methods: We conducted a descriptive and retrospective case series including 433 patients with lymphoma diagnosed from 1998 to 2008. Results: Av [...] erage age of patients was 44.8 years, and 60.04% were male. Most frequent birthplace and living area was Lima, with 61.5% and 90% of all patients, respectively. Most frequent symptoms were weight loss and lymph node enlargement (40.5% and 3,7%, respectively). More than half of all patients (55.08%) were in I-II clinical stages. The most frequent location of the disease was in the lymph nodes (55.1%). Extranodal locations were the gastrointestinal tract (15.2%) and the skin (10.8%). The B immunophenotype corresponded to 57.8% o all non-Hodgkin lymphoma cases, and the most common histological type was diffuse large cell lymphoma (35.8%), and Hodgkin’s disease accounted for 14.08%. Of all treated patients, 78.12% had complete and partial response. Therapy for Hodgkin’s disease was ABVD, with 90.97% of all patients achieving complete and/or partial response. Only 23.45% of all patients were reported as dead. Conclusions: Lymphoma patients seen in Cayetano Heredia National Hospital have similar characteristics compared to was is reported in a worldwide basis.

Juan José, Padilla Valdez; Victor, Ulloa Pérez; Diego, Venegas Ojeda.

2011-01-01

141

Recurrent disseminated intravascular coagulation caused by intermittent dosing of rifampin.  

Science.gov (United States)

Daily rifampin therapy is associated with minimal adverse effects, but administration on an intermittent or interrupted basis has been associated with severe immunoallergic reactions such as hemolytic anemia, acute renal failure, and disseminated intravascular coagulation. We describe a patient with Mycobacterium leprae infection who experienced recurrent episodes of disseminated intravascular coagulation after intermittent exposures to rifampin, and review eight previously reported cases of rifampin-associated disseminated intravascular coagulation. In six (75%) cases, previous exposure to rifampin was reported and seven (87.5%) patients were receiving the medication on an intermittent or interrupted basis. Clinical features of rifampin-associated disseminated intravascular coagulation included fever, hypotension, abdominal pain, and vomiting within hours of ingestion. Average time to reaction was 3-6 doses if rifampin was being administered on a monthly schedule. Three (37.5%) of eight reported cases were fatal. A complete history of previous exposure to rifampin is recommended before intermittent therapy with this medication. PMID:22302861

Havey, Thomas C; Cserti-Gazdewich, Christine; Sholzberg, Michelle; Keystone, Jay S; Gold, Wayne L

2012-02-01

142

Recurrent Disseminated Intravascular Coagulation Caused by Intermittent Dosing of Rifampin  

Science.gov (United States)

Daily rifampin therapy is associated with minimal adverse effects, but administration on an intermittent or interrupted basis has been associated with severe immunoallergic reactions such as hemolytic anemia, acute renal failure, and disseminated intravascular coagulation. We describe a patient with Mycobacterium leprae infection who experienced recurrent episodes of disseminated intravascular coagulation after intermittent exposures to rifampin, and review eight previously reported cases of rifampin-associated disseminated intravascular coagulation. In six (75%) cases, previous exposure to rifampin was reported and seven (87.5%) patients were receiving the medication on an intermittent or interrupted basis. Clinical features of rifampin-associated disseminated intravascular coagulation included fever, hypotension, abdominal pain, and vomiting within hours of ingestion. Average time to reaction was 3–6 doses if rifampin was being administered on a monthly schedule. Three (37.5%) of eight reported cases were fatal. A complete history of previous exposure to rifampin is recommended before intermittent therapy with this medication. PMID:22302861

Havey, Thomas C.; Cserti-Gazdewich, Christine; Sholzberg, Michelle; Keystone, Jay S.; Gold, Wayne L.

2012-01-01

143

Causas de mortalidad en pacientes con linfoma de Hodgkin / Causes of mortality in patients with Hodgkin lymphoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Se realizó un estudio retrospectivo-descriptivo en el Servicio de Hematología del Hospital Clinicoquirúrgico "Hermanos Ameijeiras" para conocer las causas de muerte en pacientes con diagnóstico de linfoma de Hodgkin tratados desde enero de 1983 hasta diciembre de 2008. De los 619 pacientes diagnosti [...] cados en ese período, la muestra quedó constituida por 443, de los cuales 287 (64,8 %) se encontraban vivos al final del estudio y 156 (35,2 %) habían fallecido. La recaída/progresión de la enfermedad fue la causa más importante de muerte, independientemente de la edad de presentación, la modalidad de tratamiento empleada y el tiempo de evolución (125 pacientes, 80 %). El 20 % restante de las muertes ocurrió por segundas neoplasias en 10 pacientes (6,4 %), complicaciones del tratamiento en 8 (5,1 %), complicaciones infecciosas fatales en 2 (1,2 %) y enfermedad cardiovascular en 3 (1,9 %). En 8 pacientes (5,1 %) no se precisó la causa de muerte. Las segundas neoplasias predominaron en pacientes de 40-59 años, que recibieron la modalidad de tratamiento combinada y con menos de 10 años de evolución. Abstract in english A retrospective descriptive study was conducted in the Hematology Service at Hermanos Ameijeriras Hospital to know the causes of death in patients with Hodgkin lymphoma, who were treated from January 1983 to December 2008. Out of 619 patients diagnosed in that period, the total sample was formed by [...] 443 patients. 287 (64.8 %) of them were alive at the end of the study, and 156 (35.2%) had died. This disease relapse/progression were the leading cause of death, regardless age of its presentation, treatment used, and the time of progression (125 patients, 80 %). The remaining 20 % of deaths occurred from secondary malignancies in 10 patients (6.4 %), complications of treatment in 8 (5.1 %), fatal infectious complications in 2 (1.2 %), and cardiovascular disease in 3 (1.9 %). In 8 patients (5.1 %) the cause of death was not stated. Secondary malignancies were predominant in patients aged 40-59, who received combined treatment with less than 10 years of evolution.

Tamara, Delgado Vargas; José, Carnot Uria; Raúl, de Castro Arenas; Jorge, Muñío Perurena; Calixto, Hernández Cruz; Aramís, Núñez Quintana; Guillermo, Pérez Román; Yusaima, Rodríguez Fraga.

2013-12-01

144

Disseminated intravascular coagulation and massive obstetric hemorrhage. Management dilemma.  

OpenAIRE

OBJECTIVES The objective of this retrospective study is to reflect on our experience on an optimal management for major postpartum hemorrhage, which would prevent the occurrence and complications of disseminated intravascular coagulation and minimize maternal mortality and morbidity. METHODS Ten cases out of the 30,000 of total deliveries of severe obstetric hemorrhage associated with disseminated intravascular coagulation were studied. This study was carried out over a 7 year period...

Al-nuaim, Lulu A.; Mustafa, Mohamed S.; Abdel Gader, Galil M.

2002-01-01

145

Chronic disseminated intravascular coagulation presenting as renal mass  

OpenAIRE

Disseminated intravascular coagulation (DIC) is a complex clinical syndrome, described as a sequential activation of the coagulation and fibrinolytic system. Trauma and sepsis are some of the known precipitating factors. We report a case of nonovert disseminated intravascular coagulation presenting as a huge renal mass in a 3-year-old child, suspected to be a Wilms? tumor. On imaging studies, it was found to be a renal hematoma. Laboratory investigations revealed an underlying chronic ...

Somashekhar Manjiri; Kadamba Padmalatha; Wakodkar Mugdha

2008-01-01

146

Acute intravascular hemolysis and methemoglobinemia following naphthalene ball poisoning.  

Science.gov (United States)

Naphthalene (C10H8) is a natural component of fossil fuels such as petroleum, diesel and coal. The common consumer products made from naphthalene are moth repellents, in the form of mothballs or crystals, and toilet deodorant blocks. Major toxic effects of naphthalene are due to precipitation of acute intravascular hemolysis. Very few cases of naphthalene poisoning and its effects have been reported from India. We report a case of accidental naphthalene poisoning, who presented with intravascular hemolysis and methemoglobinemia. PMID:25332608

Kapoor, Rajan; Suresh, P; Barki, Satish; Mishra, Mayank; Garg, M K

2014-09-01

147

A Fatal Case of Intravascular Coagulation After Bee Sting Acupuncture  

OpenAIRE

Bee stings can cause severe adverse reactions, leading to anaphylaxis, cardiovascular collapse, and death. In some cases, bee venom also induces disseminated intravascular coagulation (DIC). However, to our knowledge, there has been no fatal case of intravascular coagulation accompanied by anaphylaxis caused by bee sting acupuncture. Here, we report a fatal case of a 65-year-old woman with DIC, following anaphylactic shock after bee sting acupuncture. This case emphasizes that practitioners s...

Jung, Jae Woo; Jeon, Eun Ju; Kim, Jeong Wook; Choi, Jae Chol; Shin, Jong Wook; Kim, Jae Yeol; Park, In Won; Choi, Byoung Whui

2011-01-01

148

T- Lymphoblastic lymphoma in adults / Linfoma linfoblástico T dos adultos  

Scientific Electronic Library Online (English)

Full Text Available O linfoma linfoblástico de célula T é raro e com prognóstico ruim. Após introdução de terapêutica quimioterápica seqüencial e intensificada, remissões completas passaram a ser obtidas em 75%-95% dos pacientes. Entretanto, muitos pacientes, particularmente aqueles com a chamada doença avançada, conti [...] nuaram a recair tanto durante a terapia de indução como na manutenção. Além disso, todos estes estudos iniciais não foram capazes de detectar qualquer índice prognóstico capaz de prever a evolução dos pacientes. No sentido de reduzir as taxas de recidiva, o transplante autólogo de célula progenitora hematopoética em pacientes em remissão completa foi introduzido. Os resultados obtidos com esta abordagem foram bastante homogêneos, indicando uma probabilidade de sobrevida livre de doença de 65%-75% e uma sobrevida global de 60%. Sucessivos tratamentos desenhados já nos anos 2000, foram capazes de obter remissões completas acima de 90%, com taxas de recidivas da ordem de 30% e uma sobrevida global comparável à obtida com o transplante. Ainda, estes estudos também não foram capazes de detectar fatores prognósticos relacionados à evolução válidos. Mais ainda, qualquer estudo com perfil biológico foi desenvolvido. Para melhorar o prognóstico do LLB-T parece ser necessário esforço multicêntrico, de caráter nacional ou internacional, para coletar dados clínicos e biológicos. Nesta linha, é possível alcançar número crítico de dados com valor estatístico que poderiam ser capazes de detectar fatores com influência prognóstica. Finalmente, grupos de pacientes necessitam ser identificados para selecionar aqueles que poderiam se beneficiar do transplante de célula progenitora hematopoética detectados ao diagnóstico. Abstract in english Adult T-lymphoblastic lymphoma is rare and has a poor prognosis. In the 80s, following the introduction of sequential, intensified chemotherapy, complete remissions in the order of 75%-95% of treated patients, were achieved. However, several patients, namely those with advanced disease, continued to [...] relapse either in remission or during maintenance therapy. Moreover, all these early studies were not able to detect any valuable prognostic index to predict the outcome. In an attempt to reduce the relapse rate, upfront autologous stem cell transplantation in patients in complete remission was introduced. The results obtained with this approach were quite homogeneous, indicating a probability of disease-free survival of about 65%-75% and an overall survival rate of 60%. Successive therapies designed since 2000 were able to obtain complete remissions of above 90%, with a relapse rate in the order of 30% and an overall survival comparable to that obtained with the transplant procedure. Yet, these studies were also unable to detect valuable prognostic factors predictive of the outcome. Moreover, no study on the biologic profile of the disease has been developed. To improve the prognosis of T-lymphoblastic lymphoma it seems necessary to create national registries to collect both clinical and biological data of all lymphoblastic lymphoma patients. In this way it will be possible to reach critical numbers of data with which valid statistical analysis may be performed that is able to detect factors influencing the outcome. Moreover, subsets of patients needing intensified procedures such as stem cell transplant may be detected at diagnosis.

Gino, Santini; Adolfo, Porcellini; Simona, Zupo; Mauro, Truini.

2008-06-01

149

Primary pulmonary AIDS-related lymphoma / Linfoma primario de pulmón en un paciente con sida  

Scientific Electronic Library Online (English)

Full Text Available El compromiso extranodal es frecuente en los linfomas asociados con la enfermedad debida al virus de la inmunodeficiencia humana y su consecuencia, el síndrome de inmunodeficiencia adquirida. Sin embargo, el linfoma pulmonar primario es muy raro y solo existen pocos casos publicados en la literatura [...] . La presentación clínica de esta complicación es inespecífica, con síntomas "B" y manifestaciones respiratorias. Generalmente, la radiografía de tórax muestra nódulos periféricos o masas que pueden cavitarse y los pacientes presentan inmunodeficiencia severa al momento del diagnóstico. El linfoma pulmonar primario asociado con el sida es un tumor de alto grado, de células B y asociado en su patogenia con el virus de Epstein-Barr. Se relata un caso de linfoma primario de pulmón que se presentó bajo la forma radiológica de una atelectasia global del pulmón izquierdo. Abstract in english Extranodal involvement is common in lymphomas associated with human immunodeficiency virus infection (HIV) and acquired immunodeficiency syndrome (AIDS). However, primary pulmonary AIDS-related non-Hodgkin's lymphoma is very rare and only few reports were published in the medical literature. Clinica [...] l presentation is nonspecific, with "B" and respiratory symptoms. Also, patients were with advanced immunodeficiency at the time of diagnosis. Generally, chest radiography showed peripheral nodules or cavitary masses. Primary pulmonary lymphoma associated with AIDS is generally a high-grade B-cell non-Hodgkin lymphoma and Epstein-Barr virus is strongly associated with the pathogenesis of these tumors. We report a patient with AIDS and primary pulmonary lymphoma which clinical presentation was a total atelectasis of the left lung.

Marcelo, Corti; María F., Villafañe; Norberto, Trione; Ricardo, Schtirbu; Marina, Narbaitz.

2005-08-01

150

Leucemia/linfoma de células T do adulto Adult T-cell leukemia/lymphoma  

OpenAIRE

A leucemia/linfoma de células T do adulto (ATL) é tipo agressivo de doença linfoproliferativa causada pelo vírus linfotrópico para células T humanas (HTLV-I), geralmente fatal e que não responde a quimioterapia. Classifica-se em formas aguda, crônica, linfomatosa e indolente (smoldering). Outra forma clínica, a tumoral primária de pele, com características diferentes, foi sugerida recentemente. As formas aguda, linfomatosa e tumoral primária de pele são as de pior prognóstico. O...

Bittencourt, Achile?a L.; Lourdes Farré

2008-01-01

151

Primary cardiac lymphoma in dogLinfoma cardíaco primário em cão  

Directory of Open Access Journals (Sweden)

Full Text Available Lymphomas are malignant neoplasm characterized by proliferation of lymphocytes that originate primarily in lymphoid organ such as lymph nodes, liver, spleen and bone marrow. However the feature of continuous migration of lymphocytes in different organs, this tumor can develop in any organ. Although lymphoma is a very common hematopoietic neoplasm in dogs, cardiac location is rare. The diagnosis of primary cardiac lymphoma may be performed when there is involvement of the heart and / or the pericardium without evidence of involvement in other organs. In veterinary medicine there are few reports on the diagnosis, treatment and prognosis of cardiac lymphoma. Therefore, the purpose of this report is to describe a case of cardiac lymphoma in which the patient responded favorably to chemotherapy employee with disease-free interval of 19 months and highlight the importance of including this neoplasm in the differential diagnosis of diseases that affect the cardiovascular system. Os linfomas são neoplasias caracterizadas pela proliferação maligna de linfócitos, que originamse principalmente em órgão linfóides como linfonodos, fígado, baço e medula óssea. Entretanto pela característica de contínua migração dos linfócitos por diferentes órgãos, esta neoplasia pode se desenvolver em qualquer órgão. Embora o linfoma seja a neoplasia hematopoiética de maior incidência em cães, a localização cardíaca é rara. O diagnóstico de linfoma cardíaco primário pode ser realizado quando há envolvimento do coração e/ou pericárdio sem evidências de ocorrência de órgãos linfáticos ou extranodais. Em medicina veterinária existem poucos relatos sobre o diagnóstico, tratamento e prognóstico desta neoplasia cardíaca. Portanto o objetivo do presente relato é descrever um caso de linfoma cardíaco em que o paciente respondeu favoravelmente ao tratamento quimioterápico empregado com intervalo livre de doença de 19 meses e salientar a importância de incluir essa neoplasia na lista de diagnósticos diferenciais de doenças que acometem o sistema cardiovascular.

Mirela Tinucci Costa

2013-10-01

152

Leucemia linfóide crônica e linfoma linfocítico de pequenas células Chronic lymphocytic leukemia and small lymphocytic lymphoma  

OpenAIRE

O linfoma linfocítico de pequenas células (LLPC) é considerado uma variante tumoral da leucemia linfocítica crônica e, por conseguinte, a mesma doença. Existem similaridades clínicas, morfológicas, imunofenotípicas e genéticas que parecem resistir até mesmo a uma análise mais aprofundada com o instrumental técnico atualmente disponível para o estudo da biologia molecular. Talvez o refinamento das técnicas de análise da expressão de multiplos genes, incluindo genes para microR...

Silla, Lucia M. R.

2005-01-01

153

Linfoma subcutâneo de células T paniculite-símile Subcutaneous panniculitis-like T-cell lymphoma  

OpenAIRE

Linfoma subcutâneo de células T paniculite-símile foi recentemente reconhecido como entidade clínico-patológica. Paciente do sexo feminino, 17 anos, relatou nodosidades eritêmato-violáceas e depressões nos membros e abdome há três anos e discreta perda ponderal, sem outros sintomas gerais. Adenomegalia, visceromegalias e infiltração da medula óssea estavam ausentes, e a histopatologia da pele mostrou densa infiltração de linfócitos atípicos CD3/CD8 no subcutâneo. A quimioter...

Renato Soriani Paschoal; Renata Nahas Cardilli; Darlene Arruda; Belinda Pinto Simões; Cacilda da Silva Souza

2009-01-01

154

La Política Criminal de los Tratados Internacionales  

Scientific Electronic Library Online (English)

Full Text Available SciELO Chile | Language: Spanish Abstract in spanish El artículo expone las principales características comunes de los "delitos de trascendencia internacional" (international crimes) contemplados en tratados y convenciones, que no constituyen "crímenes de derecho internacional" (crimes under international law), presentando un rudimiento de sistematiza [...] ción de su parte general, en el sentido de la dogmática continental. Se sostiene que los hechos comprendidos en tales categorías, que en general afectan la libertad, la vida y la seguridad personal, se reconocen como delictivos por un amplio número de Estados, lo que podría ser indicador de la existencia de un incipiente "Estado mundial", con reglas comunes de penalización al mismo tiempo necesitadas de implementación por parte de los Estados e independientes de la existencia de un órgano supranacional para hacerlas efectivas Abstract in english This article exposes the principal characteristics that are common to the international crimes contemplated in treaties and conventions which do not constitute "crimes under international law", presenting a rudiment of systematization of its general part in the sense of the continental dogmatic. It [...] is sustained that the facts understood in these categories, which in general affects the liberty, the life, and the personal security considered as crimes by a wide number of States which could be an indicator of the existence of an incipient "world state", with common rules of penalization at the same time needed to implement by the states and independents of the existence of an supranational organ to make these effective

Jean Pierre, Matus A.

155

Linfoma primario de célula B grande de próstata. Comunicación de un caso  

Directory of Open Access Journals (Sweden)

Full Text Available El linfoma prostático representa 0.09% de los tumores malignos de ese órgano. La forma de presentación habitual consta de signos de prostatismo y se descubre, predominantemente, de manera incidental por medio de tejido obtenido por resección transuretral de próstata. La sensibilidad de la biopsia transrectal es de 22%. El linfoma de próstata casi siempre es indistinguible de un adenocarcinoma, e incluso, puede encontrarse una próstata pétrea, fija y mal delimitada. En el estudio anatomopatológico se observan intensos infiltrados linfohistiocitarios. En estos pacientes debe tomarse en cuenta la posible existencia de una afectación linfática sistémica, por lo que es conveniente realizar mielograma, biopsia de médula ósea, tomografía computada toracoabdominal y gammagrama óseo. El diagnóstico se corrobora por medio de inmunohistoquímica con la detección de linfocitos B en el inmunomarcaje. El tratamiento consiste en la desobstrucción con alivio de los síntomas urinarios, así como de quimioterapia a base de ciclofosfamida, adriamicina, vincristina y prednisona con rituximab. Se comunica un caso de linfoma prostático destacando su infrecuencia con el fin de llamar la atención de la comunidad médica para realizar un abordaje diagnóstico y terapéutico adecuado. En el caso que se comunica, tras seis ciclos de quimioterapia, no se encontró actividad tumoral ni adenopatías retroperitoneales en los seguimientos radiológicos.

Salim Antonio Villacis Fonseca

2012-01-01

156

Linfoma tipo MALT de la glándula parótida / Lymphoma type MALT of the parotid gland  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Los linfomas tipo MALT (tejido linfoideo asociado a mucosa), constituyen la variedad más recientemente descubierta de los linfomas no Hodgkin, tienen lugar fundamentalmente en la mucosa gástrica asociados a infección por Helycobacter pylori, y en la glándula tiroides en relación con la tiroiditis de [...] Hashimoto. Sin embargo, internacionalmente se han descrito casos en glándulas salivales asociados a linfoadenitis. La naturaleza de la lesión a menudo no puede ser determinada solo por el estudio citológico; se hace necesario el análisis histopatológico para el diagnóstico definitivo en la mayoría de los casos. El presente estudio muestra un paciente masculino con aumento de volumen bilateral de ambas glándulas parótidas y diagnóstico citohistopatológico de un proceso linfoepitelial benigno, el cual desarrolló un linfoma tipo MALT en relación con la glándula parótida derecha. Abstract in english The lymphomas type MALT or the mucosa-associated lymphoid tissue, are the most recent variety of non-Hodgkin lymphomas present mainly in the gastric mucosa associated with Helycobacter pylori infection and in the thyroid gland in relation to Hashimoto's thyroiditis. Frequently the origin of this les [...] ion can't be determined only by cytology study, thus it is necessary the histopathology analysis for a definitive diagnosis in most cases. Present paper includes the case of male patient with bilateral volume increase of both parotid glands and a diagnosis cytopathological of a benign lymphoepithelial process and the development of a type MALT lymphoma in relation to the right parotid gland.

Carlos, Frómeta Neira; Juan Manuel, González Gómez; Miguel, Arredondo López.

2010-09-01

157

Linfoma tipo MALT de la glándula parótida Lymphoma type MALT of the parotid gland  

Directory of Open Access Journals (Sweden)

Full Text Available Los linfomas tipo MALT (tejido linfoideo asociado a mucosa, constituyen la variedad más recientemente descubierta de los linfomas no Hodgkin, tienen lugar fundamentalmente en la mucosa gástrica asociados a infección por Helycobacter pylori, y en la glándula tiroides en relación con la tiroiditis de Hashimoto. Sin embargo, internacionalmente se han descrito casos en glándulas salivales asociados a linfoadenitis. La naturaleza de la lesión a menudo no puede ser determinada solo por el estudio citológico; se hace necesario el análisis histopatológico para el diagnóstico definitivo en la mayoría de los casos. El presente estudio muestra un paciente masculino con aumento de volumen bilateral de ambas glándulas parótidas y diagnóstico citohistopatológico de un proceso linfoepitelial benigno, el cual desarrolló un linfoma tipo MALT en relación con la glándula parótida derecha.The lymphomas type MALT or the mucosa-associated lymphoid tissue, are the most recent variety of non-Hodgkin lymphomas present mainly in the gastric mucosa associated with Helycobacter pylori infection and in the thyroid gland in relation to Hashimoto's thyroiditis. Frequently the origin of this lesion can't be determined only by cytology study, thus it is necessary the histopathology analysis for a definitive diagnosis in most cases. Present paper includes the case of male patient with bilateral volume increase of both parotid glands and a diagnosis cytopathological of a benign lymphoepithelial process and the development of a type MALT lymphoma in relation to the right parotid gland.

Carlos Frómeta Neira

2010-09-01

158

Linfoma malt primario de la lengua / Primary malt limphoma of the tongue  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish Los linfomas derivados de los tejidos linfoides asociados a las mucosas (MALT) primarios de la lengua son infrecuentes. Se documenta el caso de una paciente de 80 años de edad, con un tumor en el dorso de la lengua filiado histológicamente como linfoma extranodal de células B. Se sugiere como posibl [...] e origen del linfoma un proceso reactivo de origen desconocido, al presentar las glándulas salivales menores adyacentes al tumor un cuadro compatible con una sialadenitis mioepitelial. Abstract in english Primitive malignant lymphoma mucosa associated lymphoid tissue (MALT) on the tongue are rare entities. We report here a case of an old woman (80 years old) with a tumor in the dorsum of the tongue, which was histologically diagnosed as an extra-nodal marginal B cell lymphoma. An inflammatory reactio [...] n resembling myoepithelial sialoadenitis was observed in the minor salivary glands adjacent at the tumour, suggesting a possible derivation of the lymphoma from a previous reactive process of unknown origin.

Gaia, Goteri; Giuliano, Ascani; Alessandra, Filosa; C, Corrado Rubini; Sonsoles, Olay; Paolo, Balercia.

2004-12-01

159

Linfoma cutâneo de células B: relato de caso Cutaneous B-cell lymphoma: a case report  

Directory of Open Access Journals (Sweden)

Full Text Available Os linfomas cutâneos são classificados em linfomas de células B ou de células T, sendo os primeiros menos freqüentes. O linfoma cutâneo de células B (LCCB pode ser primário ou secundário, tendo o último história natural mais agressiva, com pior prognóstico. Os autores apresentam um caso de LCCB secundário com três anos de evolução, curso indolente, sem envolvimento de outros órgãos além da pele, com ótima resposta ao tratamento quimioterápico. A distinção entre LCCB primário e secundário é muito difícil de ser realizada, uma vez que eles são clínica e histopatologicamente indistinguíveis. Deve-se sempre pesquisar o acometimento de órgãos internos para então definir o prognóstico.Cutaneous lymphomas are classified as either type B cell or T cell lymphoma, the former type being less frequent. Cutaneous B cell lymphoma (CBCL may be primary or secondary. The latter has a more aggressive natural history with a worse prognostic. In this paper, the authors present a secondary CBCL case with a three-year evolution, indolent course, without involvement of other organs beside the skin and with optimal response to chemotherapeutic treatment. The distinction between primary and secondary CBCL is very difficult to determine insofar as they are clinically and histopathologically indistinguishable. It is always necessary to investigate whether internal organs have been affected prior to defining the prognosis.

Mariana de Gusmão Nunes

2004-12-01

160

Linfoma cutâneo de células B: relato de caso / Cutaneous B-cell lymphoma: a case report  

Scientific Electronic Library Online (English)

Full Text Available Os linfomas cutâneos são classificados em linfomas de células B ou de células T, sendo os primeiros menos freqüentes. O linfoma cutâneo de células B (LCCB) pode ser primário ou secundário, tendo o último história natural mais agressiva, com pior prognóstico. Os autores apresentam um caso de LCCB sec [...] undário com três anos de evolução, curso indolente, sem envolvimento de outros órgãos além da pele, com ótima resposta ao tratamento quimioterápico. A distinção entre LCCB primário e secundário é muito difícil de ser realizada, uma vez que eles são clínica e histopatologicamente indistinguíveis. Deve-se sempre pesquisar o acometimento de órgãos internos para então definir o prognóstico. Abstract in english Cutaneous lymphomas are classified as either type B cell or T cell lymphoma, the former type being less frequent. Cutaneous B cell lymphoma (CBCL) may be primary or secondary. The latter has a more aggressive natural history with a worse prognostic. In this paper, the authors present a secondary CBC [...] L case with a three-year evolution, indolent course, without involvement of other organs beside the skin and with optimal response to chemotherapeutic treatment. The distinction between primary and secondary CBCL is very difficult to determine insofar as they are clinically and histopathologically indistinguishable. It is always necessary to investigate whether internal organs have been affected prior to defining the prognosis.

Mariana de Gusmão, Nunes; Ana Paula Soares de Moura, Pierro; Maria Fernanda Villela, Coutinho; José Carlos Oliveira de, Morais; Sueli Coelho da Silva, Carneiro; David Rubem, Azulay.

2004-12-01

161

A Dual-Modality Probe Utilizing Intravascular Ultrasound and Optical Coherence Tomography for Intravascular Imaging Applications  

OpenAIRE

We have developed a dual-modality biomedical imaging probe utilizing intravascular ultrasound (IVUS) and optical coherence tomography (OCT). It consists of an OCT probe, a miniature ultrasonic transducer and a fixed mirror. The mirror was mounted at the head of the hybrid probe 45° relative to the light and the ultrasound beams to change their propagation directions. The probe was designed to be able to cover a larger area in blood vessel by IVUS and then visualize a specific point at a much...

Yang, Hao-chung; Yin, Jiechen; Hu, Changhong; Cannata, Jonathan; Zhou, Qifa; Zhang, Jun; Chen, Zhongping; Shung, K. Kirk

2010-01-01

162

Disseminated intravascular coagulation or extended intravascular coagulation in massive pulmonary embolism  

Science.gov (United States)

See also Leitner JM, Jilma B, Spiel AO, Sterz F, Laggner AN, Janata KM. Massive pulmonary embolism leading to cardiac arrest is associated with consumptive coagulopathy presenting as disseminated intravascular coagulation. This issue, pp 1477–82; Thachil J. DIC score predicts mortality in massive clot coagulopathy as a result of extensive pulmonary embolism: a rebuttal. This issue, pp 1657–8; Leitner JM, Janata-Schwatzek K, Spiel AO, Sterz F, Laggner AN, Jilma B. DIC score predicts mortality in massive clot coagulopathy as a result of extensive pulmonary embolism: reply to a rebuttal. This issue, pp 1658–9. PMID:20412432

LEVI, M

2010-01-01

163

[Intravascular ultrasound--the new gold standard?].  

Science.gov (United States)

Intravascular ultrasound (IVUS) has evolved to a research tool to an intrinsic part of modern invasive cardiology. The main reason is the capability to obtain "in-vivo" micro anatomy by means of miniaturized echo-transducers with an outer diameter of 2.9-3.5 French. For the first time it is possible to base decisions not only on lumenograms but also on vessel wall assessment. The capabilities of IVUS can be divided in its diagnostic and intervention associated potentials. The diagnostic strength of IVUS is the ability to monitor compensatory coronary artery enlargement as a response to arteriosclerosis, to assess intermediate lesions, to reveal occult left main stem disease, and angiographically "silent" arteriosclerosis. In conjunction with the estimation of intracoronary flow reserve, patients with the diagnosis of coronary "syndrome X" can be better classified into those with or without early signs of arteriosclerosis. Additionally, IVUS is at present the only method allowing the classification of coronary artery lesions according to the AHA/ACC Stary classification. The intervention associated potentials of IVUS are the ability to allow optimal device selection, i.e. rotablators in calcified lesions or atherectomy devices in large plaque burden. The effects of PTCA on vessel wall morphology can be studied in great detail and the effect on luminal gain can be assessed almost on-line. The correlation between IVUS and angiography for estimation of luminal dimensions is inferior, because angiography is not able to describe complex luminal geometries. Several groups showed that the residual plaque area even after angiographically successful PTCA lies still in the range of 60%. A significant reduction of this number may influence long-term outcome after PTCA. Minimal luminal areas and residual plaque area after PTCA seem to be an indicator of restenosis, while the presence or absence of dissections seem to be less predictive. Additionally, the main mechanism of restenosis after PTCA is vessel shrinkage, not intimal hyperplasia. Intravascular monitoring of stent expansion led to high-pressure stent deployment with significant increase in post-procedural luminal diameters and finally the ability to withhold anticoagulation in patients with optimal stent deployment and to lower subacute stent thrombosis rates. First results for IVUS guided PTCA show a superior gain in post procedural free lumen without an increased complication rate. In the future, integrated devices, like balloons on IVUS catheters, steerable catheters, integrated flow and pressure transducers, tissue characterisation, and 0.018 inch IVUS guidewires will further enhance the usefulness of IVUS. PMID:9782590

Görge, G; Ge, J; von Birgelen, C; Erbel, R

1998-08-01

164

Intravascular probe for detection of vulnerable plaque  

Science.gov (United States)

Coronary angiography is unable to define the status of the atheroma, and only measures the luminal dimensions of the blood vessel, without providing information about plaque content. Up to 70% of heart attacks are caused by minimally obstructive vulnerable plaques, which are too small to be detected adequately by angiography. We have developed an intravascular imaging detector to identify vulnerable coronary artery plaques. The detector works by sensing beta or conversion electron radiotracer emissions from plaque-binding radiotracers. The device overcomes the technical constraints of size, sensitivity and conformance to the intravascular environment. The detector at the distal end of the catheter uses six 7mm long by 0.5mm diameter scintillation fibers coupled to 1.5m long plastic fibers. The fibers are offset from each other longitudinally by 6mm and arranged spirally around a guide wire in the catheter. At the proximal end of the catheter the optical fibers are coupled to an interface box with a snap on connector. The interface box contains a position sensitive photomultiplier tube (PSPMT) to decode the individual fibers. The whole detector assembly fits into an 8-French (2.7 mm in diameter) catheter. The PSPMT image is further decoded with software to give a linear image, the total instantaneous count rate and an audio output whose tone corresponds to the count rate. The device was tested with F-18 and Tl-204 sources. Spectrometric response, spatial resolution, sensitivity and beta to background ratio were measured. System resolution is 6 mm and the sensitivity is >500 cps / micrometers Ci when the source is 1 mm from the detector. The beta to background ratio was 11.2 for F-18 measured on a single fiber. The current device will lead to a system allowing imaging of labeled vulnerable plaque in coronary arteries. This type of signature is expected to enable targeted and cost effective therapies to prevent acute coronary artery diseases such as: unstable angina, acute myocardial infarction, and sudden cardiac death.

Patt, Bradley E.; Iwanczyk, Jan S.; MacDonald, Lawrence R.; Yamaguchi, Yuko; Tull, Carolyn R.; Janecek, Martin; Hoffman, Edward J.; Strauss, H. William; Tsugita, Ross; Ghazarossian, Vartan

2001-12-01

165

Linfoma conjuntival tipo MALT bilateral en adolescente / Bilateral Conjunctival MALT Lymphoma in an Adolescent  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Los linfomas tipo MALT primarios de conjuntiva son infrecuentes y es mucho menor la afectación conjuntival exclusiva, su bilateralidad es poco común, representan el 5% del total de los linfomas no Hodgkin extranodales; son linfomas B de bajo grado derivados de linfocitos de la zona marginal con alte [...] raciones moleculares que han bloqueado su apoptosis. Se presentó un caso de linfoma tipo MALT primario de la conjuntiva tarsal inferior de ambos ojos, en un niño de 12 años de edad, que acudió por enrojecimiento y molestias en ambos ojos de un año de evolución. Al realizar el examen físico presentó discreta ptosis del ojo izquierdo de un milímetro, masa de color anaranjada-salmón en fondo saco conjuntival inferior en ambos ojos, no adherida a planos profundos. El rayo x de órbita y la tomografía axial de cráneo no arrojó alteraciones. Se realizó hematología completa, pruebas de coagulación, bioquímica elemental y toda la analítica fue normal. El estudio anatomopatológico reportó: infiltrado linfoide denso y extenso constituido por linfocitos pequeños, algunos de aspecto plasmocitoide, sin nucléolo y sin indentación, dichos datos sugieren proliferacion linfoide maligna. Se confirmó el diagnóstico de linfoma B de bajo grado de tipo MALT. Abstract in english The primary MALT lymphomas of the conjunctiva are uncommon, the conjunctival affection is less frequent, and its bilaterality is uncommon, representing 5% of all extranodal non- Hodgkin lymphomas. Low-grade B lymphomas derived from marginal zone lymphocytes with molecular alterations are those that [...] have blocked its apoptosis. A 12 -year- old patient with primary MALT type lymphoma of the lower tarsal conjunctiva of both eyes was presented in this paper. The patient was healthy and presented redness and discomfort in both eyes in a year of evolution. The physical examination showed discrete ptosis of the left eye of a millimeter. Mass of orange - salmon color in lower conjunctival sac of both eyes, not adhered to deep planes was observed. Orbital X-ray and cranial CT were unaltered. Complete hematology, coagulation tests, and all elemental analytical biochemistry were performed, the results were normal. The pathological study reported: dense and extensive infiltrate lymphoid, composed of small lymphocytes, some without nucleolus plasmacytoid appearance without indentation, these data suggested a malignant lymphoid proliferation. The diagnosis of low-grade B-cell lymphoma of MALT type was confirmed.

Hiram Luis, Mena Estévez; Mabel Marilín, Calderín López; Deysi Mayle, Oquendo Calderín; Hiram Alejandro, Mena Calderín; Diagnis, Rodriguez Verdecia.

2014-03-01

166

Risk stratification for indolent lymphomas / Estratificação de risco dos linfomas indolentes  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese Os linfomas de células B indolentes representam aproximadamente 40% do total de linfomas não Hodgkin (LNHs). O avanço das tecnologias novas tem contribuído para a melhora no diagnóstico e classificação dos LNH indolentes. O linfoma folicular é o mais comum e sua frequência varia significantemente pe [...] lo mundo. Adescrição do Índice Internacional de Prognóstico dos linfomas folicular (FLIPI) representa um passo importante na identificação de subgrupos de pacientes, mas seu uso na prática clínica ainda necessita ser estabelecido. O uso de um número maior de anticorpos monoclonais para imunoistoquímica, estudo citogenético incluindo citogenética convencional ou hibridização in-situ por fluorescência (FISH), bem como o desenvolvimento de técnicas de alta resolução incluindo a expressão por microarray possibilita maior acurácia no diagnóstico e definição precisa dos biomarcadores com valor na estratificação de risco. A identificação de genes específicos para os diversos tipos de linfomas permite o reconhecimento de potenciais proteínas alvo que podem ser validadas usando imunoistoquímica. Análises da expressão do perfil de genes ou variações genéticas constitutivas pode também prover conhecimentos adicionais para o prognóstico em um futuro próximo. Um entendimento da biologia desses distintos tumores linfoides permite-nos identificar novos grupos de genes relacionados à doença e deve facilitar o desenvolvimento diagnóstico, predizendo a evolução e permitindo tratamentos personalizados. Abstract in english Indolent B-cell lymphomas account for approximately 40% of all non-Hodgkin lymphomas (NHLs). Advances in technology have contributed to improvements in the diagnosis and classification of indolent non-Hodgkin lymphomas. Follicular Lymphomas are the most common although the frequency varies significa [...] ntly throughout the world. The description of the Follicular Lymphoma International Prognostic Index (FLIPI) was an important step in identifying patient subgroups, but its use in the clinical practice has not been established yet. The use of a larger number of paraffin active monoclonal antibodies for immunohistochemistry, molecular cytogenetic studies including standard cytogenetics, multi-color fluorescence in-situ hybridization (FISH), polymerase chain reaction and locus-specific fluorescence insitu hybridization as well as developments in high-resolution techniquesincluding microarray gene expression profiling allow more accurate diagnosis andprecise definition of biomarkers of value in risk stratification. The identification ofdiseasespecific gene lists resulting from expression profiling provides a number ofpotential protein targets that can be validated using immunohistochemistry. Analysesof gene expression profiles or constitutive gene variations may also provide additional insight for prognostication in the near future. A comprehensive understanding of the biology of these distinct lymphoid tumors will allow us to identify novel diseaserelated genes and should facilitate the development of improved diagnosis, outcome prediction, and personalized approaches to treatment.

Abrahão Elias, Hallack Neto; Renata Oliveira, Costa; Angelo, Atalla; Frederico Luiz, Dulley; Dalton Alencar Fischer, Chamone; Juliana, Pereira.

167

Linfoma não Hodgkin primário da coluna vertebral / Primary non-Hodgkin's lymphoma of the vertebral column  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese O linfoma primário do osso (LPO) é uma condição extremamente rara, habitualmente confundida com outras lesões ósseas primárias. É responsável por cerca de 3%-5% de todos os tumores malignos no osso e 4%-7% de todos os linfomas nãoHodgkin extranodais. Caracteriza-se pelo envolvimento de um ou vários [...] locais ósseos, com ou sem comprometimento de linfonodos regionais e vísceras. Histopatologicamente, o linfoma non Hodgkin de grandes células B representa a maioria dos casos de LPO. Ossos longos são mais frequentemente comprometidos, e o fêmur é o sítio mais acometido. Osso ilíaco e da coluna vertebral também podem ser atingidos. Relatamos um caso raro de linfoma não Hodgkin da vértebra em mulher de 41 anos. A imuno-histoquímica revelou CD20 e CD45 positivos. Ela foi diagnosticada com linfoma primário difuso de grandes células B da coluna vertebral. O estudo histopatológico da medula óssea não detectou infiltração por hemopatia linfoide. A paciente foi tratada com quimioterapia CHOP juntamente com etoposide, seguida de radioterapia (dose total = 3600cGy) na região tóraco-lombar. Não houve evidência de recidiva em um período de vinte meses de acompanhamento. Abstract in english Primary bone lymphoma (PBL) is an extremely rare condition, commonly confused with other primary bone injuries. It accounts for approximately 3-5% of all malignant bone tumors and 4-7% of all extranodal non-Hodgkin's lymphomas. It is characterized by the involvement of one or multiple bone locations [...] , with or without the involvement of regional lymph nodes and viscera. Histopathologically, diffuse large-B-cell lymphomas account for the majority of cases of PBL. Long bones are usually involved, with the femur being the most commonly affected site. Pelvic bones and the vertebral column can also be involved. We report on a rare case of PLB of the vertebra in a 41-year-old woman. Immunohistochemistry examinations revealed CD20 and CD45 positive cells. She was diagnosed with primary diffuse large B-cell lymphoma presenting as a vertebral column tumor. The histopathologic analysis of the bone marrow did not show lymphoproliferative disorders. The patient was treated with a CHOP plus etoposide regimen. Systemic chemotherapy was followed by radiotherapy (total dose = 3600 cGy) in the thoracolumbar region. There was no evidence of recurrence in the 20-month follow up.

Ronald F., Pinheiro; Francisco D., Rocha Filho; Francisco V. A., Ferreira; Gabrielle G., Lima; Jacqueline H., Souza; Michelle G., Lima.

168

Primary cutaneous centrofollicular lymphoma with a good response to radiotherapy / Linfoma centrofolicular cutâneo primário com boa resposta a radioterapia  

Scientific Electronic Library Online (English)

Full Text Available Os linfomas cutâneos primários têm comportamento clínico e prognóstico diferente dos linfomas sistêmicos de subtipo histológico semelhante. Cerca de 30% dos linfomas não-Hodgkin acometem tecidos extranodais, sendo a pele o segundo órgão mais envolvido após o trato gastrointestinal (aproximadamente 1 [...] 8%). De acordo com a classificação EORTC (European Organization for Research and Treatment of Cancer), o linfoma centrofolicular cutâneo é indolente, uma vez que as lesões aumentam de tamanho lentamente ao longo dos anos e a disseminação para sitios extracutâneos é incomum. Com base nisso, a radioterapia tem sido apontada como o tratamento de primeira escolha por muitos estudos. Apresentamos um caso de paciente com linfoma cutâneo centrofolicular no couro cabeludo há 1 ano e que apresentou boa resposta à radioterapia. Abstract in english Primary cutaneous lymphomas have different clinical behavior and prognosis than systemic lymphomas of similar histological subtype. About 30% of non-Hodgkin lymphomas involve extranodal tissues, the skin being the second most affected body organ after the gastrointestinal tract (approximately 18%). [...] According to the EORTC (European Organization for Research and Treatment of Cancer) classification, the lymphoma centrofollicular is indolent, since the lesions increase in size slowly over the years and spread to extracutaneous sites is uncommon. Based on this, radiotherapy has been considered the treatment of choice by many studies. We present the case of a patient who had cutaneous centrofollicular scalp lymphoma for 1 year and showed good response to radiotherapy.

Cláudia Medeiros dos Santos, Camargo; Lislaine, Bomm; Leonardo Spagnol, Abraham; Rafael, Daher; Maria de Fátima Guimarães, Scotelaro; Luna Azulay, Abulafia.

2013-12-01

169

Burkitt-like lymphoma in an infant: a case report / Linfoma burkitt-like em um lactente: relato de caso  

Scientific Electronic Library Online (English)

Full Text Available Os linfomas não Hodgkin da infância, incluindo os linfomas de Burkitt e Burkitt-like são raros em lactentes. Um caso de linfoma não Hodgkin B em uma lactente de 13 meses de idade é descrito. Ao diagnóstico a paciente apresentava extenso comprometimento abdominal associado à ascite, derrame pleural e [...] síndrome de lise tumoral. A análise imunofenotípica mostrou um fenótipo compatível com células linfóides oriundas do centro germinativo e a origem clonal dessas células foi demonstrada por reação em cadeia da polimerase. Não foi demonstrada associação do linfoma com infecção pelo vírus Epstein-Barr e/ou virus da imunodeficiência adquirida. O caso apresentado enfatiza a necessidade de considerar o diagnóstico de linfoma mesmo em lactentes. Abstract in english Childhood non-Hodgkin's lymphomas, including Burkitt and Burkitt-like, are rarely diagnosed in infants. A case of B-cell lymphoma in a 13-month-old girl with extensive abdominal disease, ascites, pleural effusion, and tumor lysis syndrome is reported. Phenotypic analysis showed a germinal center B-c [...] ell phenotype, and a B-cell clonality was confirmed by polymerase chain reaction. There was no evidence of Epstein-Barr and HIV infection. The case herein reported emphasizes the need for considering the diagnosis of lymphoma even in very young children.

Claudete Esteves, Klumb; Lídia Maria Magalhães de, Resende; Claudio Gustavo, Stefanoff; Carlos Humberto, Vicuña; Ilana Zalcberg, Renault; Raquel Ciuvalschi, Maia.

170

[Disseminated intravascular coagulation in eperythrozoonosis of swine].  

Science.gov (United States)

Investigations were carried out on the influence of latent and clinically manifest Eperythrozoon suis infection upon haemostasis in swine. The study was carried out with 14 German Landrace pigs. Latent eperythrozoonosis was induced in 7 animals by experimental infection. Splenectomy of these 7 animals and 2 spontaneously infected pigs led to clinical manifestation of eperythrozoonosis. Five clinically healthy pigs were splenectomized and served as controls. In healthy pigs splenectomy was followed by a transient rise in fibrinogen and platelet count. Latent infection with Eperythrozoon suis did not cause an impairment of haemostasis. Acute eperythrozoonosis was associated with increased haemorrhagic tendency considered to be a consequence of intravascular coagulation and subsequent consumption coagulopathy. There was a prolongation of partial thromboplastin time and prothrombin time (Quick) and a decrease of platelet count. Thrombelastography showed prolongation of reaction and clot building time and a short-term decrease of maximum amplitude. Deviation from normal values was proportional to the number of red blood cells infected with Eperythrozoon suis. Anti-rickettsial therapy led to quick normalization of haemostasis. Various aspects of the cause and the consequences of the haemostatic defect are discussed with special regard to the underlying disease. PMID:2302156

Plank, G; Heinritzi, K

1990-01-01

171

Rotational multispectral fluorescence lifetime imaging and intravascular ultrasound: bimodal system for intravascular applications  

Science.gov (United States)

We report the development and validation of a hybrid intravascular diagnostic system combining multispectral fluorescence lifetime imaging (FLIm) and intravascular ultrasound (IVUS) for cardiovascular imaging applications. A prototype FLIm system based on fluorescence pulse sampling technique providing information on artery biochemical composition was integrated with a commercial IVUS system providing information on artery morphology. A customized 3-Fr bimodal catheter combining a rotational side-view fiberoptic and a 40-MHz IVUS transducer was constructed for sequential helical scanning (rotation and pullback) of tubular structures. Validation of this bimodal approach was conducted in pig heart coronary arteries. Spatial resolution, fluorescence detection efficiency, pulse broadening effect, and lifetime measurement variability of the FLIm system were systematically evaluated. Current results show that this system is capable of temporarily resolving the fluorescence emission simultaneously in multiple spectral channels in a single pullback sequence. Accurate measurements of fluorescence decay characteristics from arterial segments can be obtained rapidly (e.g., 20 mm in 5 s), and accurate co-registration of fluorescence and ultrasound features can be achieved. The current finding demonstrates the compatibility of FLIm instrumentation with in vivo clinical investigations and its potential to complement conventional IVUS during catheterization procedures.

Ma, Dinglong; Bec, Julien; Yankelevich, Diego R.; Gorpas, Dimitris; Fatakdawala, Hussain; Marcu, Laura

2014-06-01

172

Hemostasia normal y coagulación intravascular diseminada en obstetricia / Normal hemostasis and disseminated intravascular clotting in Obstetrics  

Scientific Electronic Library Online (English)

Full Text Available En el período gravido - puerperal, la coagulación sanguínea sufre cambios que se impone conocer para interpretar correctamente esos trastornos cuando se presentan en esta etapa, teniendo en cuenta las posibles complicaciones y el peligro para la vida que pueden presentarse. El objetivo del presente [...] artículo es proporcionar a los obstetras una revisión bibliográfica que les permita actualizarse acerca del tema y facilite su modo de actuación ante pacientes con coagulación intravascular diseminada. Se concluye que es preciso diagnosticar tempranamente el proceso en la fase bioquímica de bajo grado y aplicar en las féminas el tratamiento expedito de la enfermedad de base para eliminar las complicaciones o disminuir su ocurrencia Abstract in english In the period from pregnancy to puerperium, blood clotting suffers changes which are important to be known in order to interpret correctly those dysfunctions when they appear in this stage, keeping in mind the possible complications and the danger for life which can take place. The objective of the [...] present work is to provide the obstetricians a literature review that allows them to be updated about the topic and facilitate their performance in case of patients with disseminated intravascular clotting. It is concluded that it is necessary to have an early diagnosis on the process during the low grade biochemical phase and to apply in these women the expedite treatment of the base disease to eliminate complications or to decrease their occurrence.

Danilo, Nápoles Méndez; Dianela, Nápoles García.

2012-03-01

173

Hemostasia normal y coagulación intravascular diseminada en obstetricia Normal hemostasis and disseminated intravascular clotting in Obstetrics  

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Full Text Available En el período gravido - puerperal, la coagulación sanguínea sufre cambios que se impone conocer para interpretar correctamente esos trastornos cuando se presentan en esta etapa, teniendo en cuenta las posibles complicaciones y el peligro para la vida que pueden presentarse. El objetivo del presente artículo es proporcionar a los obstetras una revisión bibliográfica que les permita actualizarse acerca del tema y facilite su modo de actuación ante pacientes con coagulación intravascular diseminada. Se concluye que es preciso diagnosticar tempranamente el proceso en la fase bioquímica de bajo grado y aplicar en las féminas el tratamiento expedito de la enfermedad de base para eliminar las complicaciones o disminuir su ocurrenciaIn the period from pregnancy to puerperium, blood clotting suffers changes which are important to be known in order to interpret correctly those dysfunctions when they appear in this stage, keeping in mind the possible complications and the danger for life which can take place. The objective of the present work is to provide the obstetricians a literature review that allows them to be updated about the topic and facilitate their performance in case of patients with disseminated intravascular clotting. It is concluded that it is necessary to have an early diagnosis on the process during the low grade biochemical phase and to apply in these women the expedite treatment of the base disease to eliminate complications or to decrease their occurrence.

Danilo Nápoles Méndez

2012-03-01

174

Linfoma de colo de útero: achados na ressonância magnética / Lymphoma of uterine cervix: magnetic resonance imaging findings  

Scientific Electronic Library Online (English)

Full Text Available Linfoma de colo uterino é uma doença rara. Cerca de 1,0% a 1,5% dos linfomas extranodais se origina no trato genital feminino. A apresentação clínica é inespecífica e a ressonância magnética é importante para a suspeita diagnóstica. Neste artigo relatamos o caso de uma paciente de 80 anos de idade c [...] om dor lombar, cuja ressonância mostrou volumosa massa uterina. O diagnóstico final foi de linfoma. Abstract in english Lymphoma of the cervix is a rare disease. About 1.0% to 1.5% of extranodal lymphomas originates in the female genital tract. The clinical presentation of this condition is nonspecific and magnetic resonance imaging is important for diagnostic elucidation. The present report describes the case of a 8 [...] 0-year-old patient with lumbar pain, whose magnetic resonance imaging showed a large uterine mass. The final diagnosis was lymphoma.

Daniel, Kanaan; Daniella Braz, Parente; Carolina Pesce Lamas, Constantino; Rodrigo Canellas de, Souza.

2012-06-01

175

Chronic disseminated intravascular coagulation presenting as renal mass  

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Full Text Available Disseminated intravascular coagulation (DIC is a complex clinical syndrome, described as a sequential activation of the coagulation and fibrinolytic system. Trauma and sepsis are some of the known precipitating factors. We report a case of nonovert disseminated intravascular coagulation presenting as a huge renal mass in a 3-year-old child, suspected to be a Wilms? tumor. On imaging studies, it was found to be a renal hematoma. Laboratory investigations revealed an underlying chronic disseminated intravascular coagulation caused by sepsis. The child recovered with conservative treatment; follow up investigations showed resolution of renal hematoma with renal function returning to base line. Clinical presentation of Chronic DIC is variable. Laboratory investigations usually help to diagnose the condition and also to monitor the progress of the treatment. The treatment of the triggering cause is the cornerstone of the management of this condition.

Somashekhar Manjiri

2008-01-01

176

The natural history of intravascular lymphomatosis.  

Science.gov (United States)

Intravascular lymphomatosis (IVL) is a rare and clinically devastating form of extranodal B-cell non-Hodgkin's lymphoma. We performed a comprehensive analysis of the literature on IVL's published between 1959 and 2011 and evaluated the natural history as well as identified prognostic and predictive factors in patients. Nonparametric two-tailed Mann-Whitney U-test and Mantel-Cox log rank test were used to evaluate the survival intervals and prognostic factors. Multivariate analysis of variance (MANOVA) and chi-squared statistics were carried out to examine treatment-related predictive factors. Of the 740 patients with IVL, 651 (88%) had a diagnosis of B-cell lymphoma, 45 (6%) with T-cell lymphoma, and 12 patients (2%) with NK cell lymphoma. Central nervous system (CNS) IVL had the highest proportion of postmortem diagnosis, 250 (60%) compared to 21 (8%) of skin, 28 (11%) of bone marrow (BM) and spleen, and 17 (7%) of lung IVL's. Age 71 and LDH >577 compared to nonrituximab, nondoxorubicin regimens (MANOVA 2 degrees of freedom, P = 0.0345), with a median time from treatment to death of 20.0 (95% confidence interval [CI] 14.0-N/A, n = 14) months versus 2.0 (95%CI 0.5-N/A, n = 5) (?(2) = 4.7, P = 0.0304). Patients with CNS IVL relapsed primarily in the CNS (88%) while same-organ relapse occurred less frequently in skin (23%), BM and spleen (50%) and lung (20%) IVL's. Our results indicate that IVL is primarily a disease of B-lymphoma cells. Timely diagnosis and treatment with rituximab-based chemotherapy improve patient survival. The pattern of recurrence is different between CNS IVL and IVL's in other organs. PMID:24931821

Fonkem, Ekokobe; Lok, Edwin; Robison, David; Gautam, Shiva; Wong, Eric T

2014-08-01

177

Incidental Intravascular Lipoleiomyomatosis in A Hysterectomy Specimen: How To Manage?  

Science.gov (United States)

Leiomyomas are common benign tumors in female gynaecologic surgery. They are originated from smooth muscle cells of the uterus and/or sometimes of the uterine vessels. Intravascular lipoleiomyomatosis is a very rare form of leiomyomas which grow within veins and can extend up to vena cava inferior and right heart chamber with cardiac symptoms and is diagnosed by cardiovascular surgeons. We report a case of incidental intravascular lipoleiomyomatosis which was confined to the uterus being diagnosed after a total abdominal hysterectomy by pathology and its management strategy. PMID:25738043

Aslanova, Rakhshanda; Can, Nuray; Okten, Sabri Berkem; Aslan, Mehmet Musa

2015-01-01

178

A study of intravascular brachytherapy treatment planning in peripheral arteries.  

Science.gov (United States)

A two-step method to determine the seed parameters for the planning of peripheral intravascular brachytherapy, which took the actual vessel geometry into consideration, was developed. Firstly, the characteristics of the vessel geometry was obtained by using active navigation; Then a method combined genetic algorithm with BFGS algorithm was applied to optimize the number of seeds, and the parameters associated with each seed such as the position, and the dwell time. Application of the method to a phantom model and three animal models of stenosis shows that promising result could be obtained, and the planning of peripheral intravascular brachytherapy should take actual vessel geometry into consideration. PMID:17282698

Zhou, Zhengdong; Haigron, Pascal; Acosta, Oscar; Shu, Huazhong; Yu, Wenxue; Luo, Liming; Manens, Jean-Pierre; Lucas, Antoine

2005-01-01

179

Hiperplasia endotelial papilar intravascular oral: uma entidade rara / Intravascular papillary endothelial hyperplasia: a rare entity  

Scientific Electronic Library Online (English)

Full Text Available A hiperplasia endotelial papilar intravascular (HEPI) é uma lesão vascular reativa caracterizada pela proliferação endotelial excessiva localizada no interior de vasos sangüíneos comumente dilatados, associada a trombos em organização, ou secundária a outras lesões vasculares, como hemangiomas e gra [...] nulomas piogênicos. A HEPI é um achado incomum na cavidade oral, onde os lábios são o principal sítio de acometimento, e surge clinicamente sob a forma de nódulos azulados de aspecto clínico semelhante ao de lesões como hemangioma, mucocele e varicosidades. Sob o aspecto histopatológico, observam-se projeções papilares de tecido conjuntivo fibroso revestidas por uma ou duas camadas de células endoteliais no interior de um lúmen vascular. A principal peculiaridade da HEPI reside em sua semelhança histológica com o angiossarcoma e na possível interpretação errônea como neoplasia maligna. Neste artigo, os autores descrevem um caso de HEPI oral e realizam uma breve revisão da literatura, enfatizando suas características histopatológicas e o diagnóstico diferencial. Abstract in english Intravascular papillary endothelial hyperplasia (IPEH) is a reactive vascular lesion characterized by excessive endothelial proliferation within a vascular lumen of commonly dilated vessels, associated to organizing thrombi or even secondary to other vascular lesions, such as hemagiomas and pyogenic [...] granulomas. Oral lesions of IPEH are uncommon, being lips the most frequent site, followed by, in decreasing frequency, tongue and buccal mucosa. Clinically, IPEH appears as bluish nodules that resembles clinical features of lesions as hemangioma, mucocele and varice. On histopathological examination, IPEH presents as papillary projections composed by a fibrous core lined by one or two layers of plump endothelial cells, without evidence of celullar pleomorphism, mitotic activity or necrosis. The mean peculiarity of IPEH is its histologic similarity to angiosarcoma and possible misinterpretation with malignant neoplasm. In this article, the author describe a rare case of oral IPEH and review of literature, emphasizing its histopathologic features and diferencial diagnosis.

João Augusto Vianna, Goulart Filho; Karuza Maria Alves, Pereira; Hébel Cavalcanti, Galvão.

2006-02-01

180

Hiperplasia endotelial papilar intravascular oral: uma entidade rara Intravascular papillary endothelial hyperplasia: a rare entity  

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Full Text Available A hiperplasia endotelial papilar intravascular (HEPI é uma lesão vascular reativa caracterizada pela proliferação endotelial excessiva localizada no interior de vasos sangüíneos comumente dilatados, associada a trombos em organização, ou secundária a outras lesões vasculares, como hemangiomas e granulomas piogênicos. A HEPI é um achado incomum na cavidade oral, onde os lábios são o principal sítio de acometimento, e surge clinicamente sob a forma de nódulos azulados de aspecto clínico semelhante ao de lesões como hemangioma, mucocele e varicosidades. Sob o aspecto histopatológico, observam-se projeções papilares de tecido conjuntivo fibroso revestidas por uma ou duas camadas de células endoteliais no interior de um lúmen vascular. A principal peculiaridade da HEPI reside em sua semelhança histológica com o angiossarcoma e na possível interpretação errônea como neoplasia maligna. Neste artigo, os autores descrevem um caso de HEPI oral e realizam uma breve revisão da literatura, enfatizando suas características histopatológicas e o diagnóstico diferencial.Intravascular papillary endothelial hyperplasia (IPEH is a reactive vascular lesion characterized by excessive endothelial proliferation within a vascular lumen of commonly dilated vessels, associated to organizing thrombi or even secondary to other vascular lesions, such as hemagiomas and pyogenic granulomas. Oral lesions of IPEH are uncommon, being lips the most frequent site, followed by, in decreasing frequency, tongue and buccal mucosa. Clinically, IPEH appears as bluish nodules that resembles clinical features of lesions as hemangioma, mucocele and varice. On histopathological examination, IPEH presents as papillary projections composed by a fibrous core lined by one or two layers of plump endothelial cells, without evidence of celullar pleomorphism, mitotic activity or necrosis. The mean peculiarity of IPEH is its histologic similarity to angiosarcoma and possible misinterpretation with malignant neoplasm. In this article, the author describe a rare case of oral IPEH and review of literature, emphasizing its histopathologic features and diferencial diagnosis.

João Augusto Vianna Goulart Filho

2006-02-01

181

Linfoma leptomeníngeo en un niño con infección por el virus de la inmunodeficiencia humana  

Scientific Electronic Library Online (English)

Full Text Available SciELO Argentina | Language: Spanish Abstract in spanish El linfoma primario del sistema nervioso central en pacientes pediátricos VIH positivos es poco frecuente. Se presenta un paciente, de siete años de edad, de sexo masculino, con síndrome de inmunodeficiencia adquirida, que desarrolló un linfoma de células B con localización leptomeníngea. El niño in [...] ició el cuadro con síntomas de alteración del sensorio, hipertensión endocraneana y amaurosis bilateral. El diagnóstico se efectuó por biopsia cerebral, inmunofenotipo de las células B del líquido cefalorraquídeo, además de PCR positiva para virus de Epstein Barr en el líquido. Realizó tratamiento con quimioterapia intratecal y sistémica. Mejoraron los síntomas durante quince meses y luego recidivó en la región talámica. Cumplió radioterapia craneoespinal y falleció cuatro meses después de la recidiva. En este artículo se realiza una revisión de la bibliografía sobre esta enfermedad, señalando el carácter excepcional de este paciente por tratarse de un linfoma localizado en forma exclusiva en el sistema nervioso central y, más precisamente, en la leptomeninges. Abstract in english Primary non-Hodgkin lymphoma in the central nervous system is rare in children and in AIDS pediatric patients. We report a seven years old boy, HIV-positive, C3 stage, who developed a non- Hodgkin lymphoma in the central nervous system, with leptomeningeal location. The patient started with signs an [...] d symptoms related to increased intracranial pressure, his conscience worsened and he became blind. The diagnosis was made through brain biopsy, immunophenotype of B cells in cerebrospinal fluid, and PCR for Epstein Barr virus in the fluid. The boy was treated with intrathecal and systemic chemotherapy. His condition improved during fifteen months, and then he presented a talamic relapse. He was treated with radiotherapy and finally died four months later. In this article we review the literature about this disease, pointing to the exceptional nature of this patient because of his lymphoma exclusively located in the central nervous system, specifically leptomeningeal.

Adriana, Scrigni; Mariana, Nastri; Susana, Rodríguez de Schiavi; Liliana, Czornyj; María, Felice; Beatriz, Mantese.

2004-10-01

182

Linfoma difuso primario de hígado: Presentación de un caso Diffuse primary hepatic lymphoma: Case report  

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Full Text Available El linfoma primario de hígado (LPH es un tumor raro y representa menos del 1% de los linfomas no Hodgkin extranodales de células B. Se reporta un caso de LPH en un paciente de sexo masculino de 32 años de edad, sin enfermedad hepática crónica, que ingresa a nuestra institución por sospecha de síndrome mononucleósico. La serología para Virus Epstein Barr fue positiva. Se observó mediante ecografía hepatoesplenomegalia con parénquima hepático heterogéneo en forma difusa. La RM demostró hepatoesplenomegalia y alteraciones en lóbulo derecho hepático, compatibles con infiltración linfoproliferativa. Se realizó biopsia hepática con guía ecográfica y el estudio histopatológico reveló un linfoma no Hodgkin difuso de células grandes con inmunofenotipo B. Se presentan las características clínicas y patológicas del caso, así como una revisión de los aspectos clínicos, hallazgos patológicos y radiológicos.Primary hepatic lymphoma (PHL is a rare tumor that represents less than 1% of extranodal non-Hodgkin B-cell lymphoma. We report a case of PHL in a 32 year-old male patient without chronic liver disease, who was admitted into our institution for suspected mononucleosis syndrome. Serology for Epstein-Barr virus was positive. Ultrasound revealed hepatosplenomegaly with diffuse heterogeneous liver parenchyma. The MRI showed hepatosplenomegaly and alterations in the right lobe of the liver compatible with lymphoproliferative infiltration. Liver biopsy was performed under ultrasound guidance, and histopathologic examination revealed a diffuse non-Hodgkin lymphoma of large cells with immunophenotype B. A clinical and a pathological case as well as a review of the clinical, pathological and radiological findings of this disease are presented.

Silvana I. Romero Vidomlansky

2011-06-01

183

Linfoma difuso primario de hígado: Presentación de un caso / Diffuse primary hepatic lymphoma: Case report  

Scientific Electronic Library Online (English)

Full Text Available El linfoma primario de hígado (LPH) es un tumor raro y representa menos del 1% de los linfomas no Hodgkin extranodales de células B. Se reporta un caso de LPH en un paciente de sexo masculino de 32 años de edad, sin enfermedad hepática crónica, que ingresa a nuestra institución por sospecha de síndr [...] ome mononucleósico. La serología para Virus Epstein Barr fue positiva. Se observó mediante ecografía hepatoesplenomegalia con parénquima hepático heterogéneo en forma difusa. La RM demostró hepatoesplenomegalia y alteraciones en lóbulo derecho hepático, compatibles con infiltración linfoproliferativa. Se realizó biopsia hepática con guía ecográfica y el estudio histopatológico reveló un linfoma no Hodgkin difuso de células grandes con inmunofenotipo B. Se presentan las características clínicas y patológicas del caso, así como una revisión de los aspectos clínicos, hallazgos patológicos y radiológicos. Abstract in english Primary hepatic lymphoma (PHL) is a rare tumor that represents less than 1% of extranodal non-Hodgkin B-cell lymphoma. We report a case of PHL in a 32 year-old male patient without chronic liver disease, who was admitted into our institution for suspected mononucleosis syndrome. Serology for Epstein [...] -Barr virus was positive. Ultrasound revealed hepatosplenomegaly with diffuse heterogeneous liver parenchyma. The MRI showed hepatosplenomegaly and alterations in the right lobe of the liver compatible with lymphoproliferative infiltration. Liver biopsy was performed under ultrasound guidance, and histopathologic examination revealed a diffuse non-Hodgkin lymphoma of large cells with immunophenotype B. A clinical and a pathological case as well as a review of the clinical, pathological and radiological findings of this disease are presented.

Silvana I., Romero Vidomlansky; Ana Julia, Nielsen; Juan Cruz, Gallo; Shigeru, Kozima.

2011-06-01

184

Invaginación ileocecal como forma de presentación de linfoma no Hodgkin en un paciente con SIDA  

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Full Text Available La invaginación intestinal es poco frecuente en el adulto. Aquí se describe el caso de un paciente adulto con SIDA que desarrolló una invaginación ileocólica secundaria a un linfoma de células B localizado en el ciego. Los hallazgos quirúrgicos fueron: íleon libre de tumor, invaginado en el ciego infiltrado por la neoplasia. Se realizó la resección del hemicolon derecho debido a la tumoración localizada en el ciego, causante de la invaginación. Se revisó la literatura inglesa y española sobre este tema.

Marcelo Corti

2008-01-01

185

Linfoma no Hodgkin laríngeo: Reporte de un caso / Laryngeal non Hodgkin Lymphoma: Case Report  

Scientific Electronic Library Online (English)

Full Text Available Los linfomas de la laringe son infrecuentes, correspondiendo a menos del 1% de las neoplasias de esta ubicación. La detección temprana puede permitir una mejor atención y eventualmente un mejor pronóstico. Se presenta un caso de linfoma no Hodgkin supraglótico derecho, correspondiente a una paciente [...] de sexo femenino de 68 años, que consulta por disfonía progresiva de varios meses de evolución que se intensifica durante el último mes. La nasofibroscopía mostró una lesión tumoral que comprometía el repliegue aritenoepiglótico derecho, con mucosa sana. La tomografía axial computarizada objetivó un tumor de hemilaringe derecha de aspecto sólido que se extendía desde la base de la epiglotis hasta la glotis. La resonancia magnética informó un proceso expansivo que comprometía la región supraglótica derecha, de aspecto benigno, sin infiltración. Se extirpó un tumor submucoso en su totalidad por tirotomía media. En el examen histopatológico se observaron elementos compatibles con linfoma no Hodgkin difuso, lo que fue confirmado por técnica de inmunohistoquímica. Se trató con esquema CHOP de quimioterapia. No ha habido recidiva tumoral al 3° año de seguimiento. Los linfomas no Hodgkin de laringe son poco frecuentes. Se describen las características y manejo de este tipo de tumores. Abstract in english Lymphomas of the larynx are rare, accounting for less than 1%% of neoplasms in this location. Early detection can allow better care, and possibly a better prognosis. We present a case of a right supraglottic Non-Hodgkin Lymphoma, corresponding to a female patient of 68 years who consulted for hoarse [...] ness of several months that progressed during the last month. Fibroscopic evaluation showed a tumor involving the right aryepiglottic fold, without mucosal lesion. Computed tomography showed a solid tumor of the right hemilarynx, that extends from base of epiglottis to glottis. Magnetic resonance showed tumor expansion process that involves the right epiglottic region, of benign appearence, without infiltration. We perform a complete removal of the submucosal tumor externally by a medial laryngeal thyroidotomy. Histopathological examination showed elements compatible with diffuse Non-Hodgkin Lymphoma, which was confirmed by immunohistochemestry. CHOP chemotherapy was indicated. Currently, patient followed up for 3 years, with no signs of tumor recurrence. Non-Hodgkin Lymphomas of the larynx are rare. We describe the characteristics and management of these tumors.

Jaime, Osorio M; Marcelo, Faraggi A; Felipe, Cardemil M.

2013-04-01

186

Linfoma testicular primario con afectación extranodal / Primary testicular lymphoma with extranodal involvement  

Scientific Electronic Library Online (English)

Full Text Available Objetivos: Presentamos un caso de masa testicular derecha en varón de 65 años con afectación sincrónica de piel y anillo de Waldeyer, datos que nos orientan a que se trate de un linfoma testicular maligno por lo característico de la presentación del cuadro clínico. Material/Resultados: Se realiza un [...] a presentación y comentarios de las características del caso clínico, así como una revisión de la literatura. Conclusiones: El linfoma testicular primario es un tumor testicular infrecuente, suponiendo no más del 9% de los tumores testiculares en las series con mayor incidencia; a su vez el linfoma testicular como tumor hematopoyético es infrecuente, con una incidencia del 1% de los linfomas, pero debido a su histopatología en la mayoría de los casos de alta malignidad, les hace ser de los tumores testiculares más agresivos. La edad de aparición es por encima de los 60 años, convirtiéndose en el tumor más frecuente para este grupo de edad. En el momento del diagnóstico el 70% de los pacientes presentan estadios I y II de Ann Arbor. Cuando el debut es en forma de estadio avanzado, las localizaciones extranodales más frecuentes son el sistema nervioso central, la piel, el anillo de Waldeyer y el pulmón. Abstract in english We report the case of a 65-year-old man who presented with a right testicular mass and synchronous involvement of skin and Waldeyer's ring. These facts led us to the working diagnosis of malignant primary testicular lymphoma. Material/Results: We present the case with comments and make a bibliograph [...] ic review of the disease. Conclusions: Primary testicular lymphoma is an uncommon testicular tumour that accounts for not more that 9% of all testicular tumours in the series with higher incidence. Testicular lymphomas are also rare among haematopoietic tumours, accounting for just 1% of all lymphomas, but due to their highly malignant histopathology they may become highly aggressive tumours. Patient age at presentation is over 60 years which makes it the most frequent tumour for this age group. 70% of recently diagnosed patients show Ann Arbor stages I and II. Tumours in advanced-stage have a predilection for spreading to extranodal sites such as central nervous system, skin, Waldeyer's ring and lungs.

Cristóbal, García Peñalver; Andrés, Lecki; Carlota, Sevilla Cecilia; Mario, Díaz Delgado; Juan Luis, Parra Escobar; Eloy, Sánchez Blasco.

2009-08-01

187

LINFOMA CUTÁNEO DE CÉLULAS B TIPO CENTRO FOLICULAR CON INFILTRACIÓN A MÉDULA ÓSEA: REPORTE DE UN CASO LINFOMA CUTÂNEO DE CÉLULAS B TIPO CENTRO FOLICULAR COM INFILTRAÇÃO NA MEDULA ÓSSEA PRIMARY CUTANEOUS FOLLICLE CENTER LYMPHOMA WITH BONE MARROW INFILTRATION: RELATÓRIO DE UM CASO  

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Full Text Available Los linfomas cutáneos primarios de células B constituyen cerca del 2025% de todos los linfomas. El linfoma cutáneo primario de células B tipo centro folicular es el subtipo más frecuente y se manifiesta principalmente en pacientes adultos con una edad media de 58 años (1, la diseminación extracutánea es muy rara y se presenta con nódulos, tumores o placas solitarios o en grupo usualmente localizados en cabeza o tronco. Presentamos el caso de una paciente con un linfoma primario cutáneo tipo centro folicular con infiltración a médula ósea.Os linfomas cutâneos primários de células B constituem cerca de 20 a 25% de todos os linfomas. O linfoma cutâneo primário de células B tipo centro folicular é o subtipo mais frequente e manifestase principalmente em pacientes adultos com uma idade média de 58 anos (1, a disseminação extracutânea é muito rara e apresentase com nódulos, tumores ou placas solitárias no grupo usualmente localizados na cabeça ou tronco. Apresentamos o caso de uma paciente com um linfoma primário cutâneo tipo centro folicular com infiltração na medula óssea.Primary B cell cutaneous lymphomas represent approximately 2025% of all lymphomas. Primary cutaneous follicle center lymphoma is the most common subtype occurring in adults with a mean age of 58 years. The disease typically presents with solitary plaques or nodules and is usually located in the head or trunk. Extra cutaneous dissemination is extremely rare. We present a case of a patient with primary cutaneous follicle center lymphoma with bone marrow infiltration.

CLAUDIA MARCELA ARENAS SOTO

2012-06-01

188

Intravascular filarial parasites elaborate cyclooxygenase-derived eicosanoids  

OpenAIRE

The nematode parasites that cause human lymphatic filariasis survive for long periods in their vascular habitats despite continual exposure to host cells. Since prostanoids formed from arachidonic acid can modulate interactions among platelets, leukocytes, and endothelial cells, we examined whether intravascular nematode parasites can elaborate prostanoids. Microfilariae of Brugia malayi utilize exogenous and endogenous arachidonic acid to generate and release two predominant prostanoids, pro...

1990-01-01

189

Disseminated intravascular coagulation in malaria: A case report  

Science.gov (United States)

Disseminated intravascular coagulation (DIC) is seen in <5% of patients with severe Plasmodium falciparum malaria and is more common in cerebral malaria. Here, we report the diagnosis and management of a case of severe P. falciparum malaria with DIC. PMID:24791054

Sailo, Laltanpuii; Pradhan, Debasis; Nongthombam, Rakesh; Bhattacharyya, Prithwis

2014-01-01

190

Erratum: Multi-frequency intravascular ultrasound (IVUS) imaging.  

Science.gov (United States)

When this paper was submitted for publication (T. Ma, et al) "Multifrequency intravascular ultrasound (IVUS) imaging," IEEE Trans. Ultrason. Ferroelectr. Freq. Control, vol. 62, no. 1, pp. 97-107, Jan. 2015), c-authors Jiawen Li and Chelsea E. Munding were erroneously omitted. PMID:25768827

Ma, Teng; Yu, Mingyue; Li, Jiawen; Munding, Chelsea; Chen, Zeyu; Fei, Chunlong; Shung, K; Zhou, Qifa

2015-03-01

191

New technologies to prevent intravascular catheter-related bloodstream infections.  

OpenAIRE

Most intravascular catheter-related infections are associated with central venous catheters. Technologic advances shown to reduce the risk for these infections include a catheter hub containing an iodinated alcohol solution, short-term chlorhexidine-silver sulfadiazine- impregnated catheters, minocycline-rifampin-impregnated catheters, and chlorhexidine- impregnated sponge dressings. Nontechnologic strategies for reducing risk include maximal barrier precautions during catheter insertion, spe...

Mermel, L. A.

2001-01-01

192

Características anatomoclínicas dos linfomas caninos na região de Botucatu, São Paulo Clinicopathological aspects of canine lymphoma in Botucatu region, São Paulo, Brazil  

OpenAIRE

Estudaram-se as características anatomoclínicas dos linfomas em cães da região de Botucatu, São Paulo. O material utilizado foi colhido de 34 cães portadores de linfoma maligno, dos quais nove eram da raça Pastor-Alemão, nove sem raça definida, cinco da raça Boxer, três animais da raça Dobermann e oito outros cada um de uma raça, 68% deles machos. A idade variou de 1 a 13 anos, com média de 6,2 anos. O estabelecimento do estádio dos linfomas foi baseado nos critérios estabelec...

Sequeira, J. L.; Franco, M.; Bandarra, E. P.; Figueiredo, L. M. A.; Rocha, N. S.

1999-01-01

193

Primary MALT lymphomas of the stomach: A pathological study of 18 cases / Linfomas gástricos primarios tipo MALT: un estudio patológico de 18 casos  

Scientific Electronic Library Online (English)

Full Text Available Objetivo: es difícil que alguien que padezca un linfoma gástrico de tipo MALT pueda librarse de la enfermedad,... a menos que se le trate con medicación para Helicobacter pylori. Material y métodos: se analizó una cohorte de 18 pacientes. Diez huéspedes tenían linfoma gástrico de tipo MALT y se trat [...] aron con resección gástrica como tratamiento inicial. Ocho recibieron antibióticos frente a Helicobacter pylori como tratamiento inicial. En los 18 pacientes se evaluaron la presencia de Helicobacter pylori, los hallazgos endoscópicos y los rasgos patológicos. Se realizó una inmunohistoquímica para valorar el bcl-2 y el p53. Resultados: los pacientes con linfoma MALT de grado bajo: a) dieron positivo a Helicobacter pylori (5 de 5); b) tenían una lesión superficial (5 de 5); c) no tenían afectados los ganglios linfáticos (5 de 5); y d) se estadificaron a la baja por comparación con los pacientes con tumores de grado alto. El bcl-2 fue positivo en 4 de los 5 tumores de grado bajo y el p53 fue positivo en 12 de 13 de los de grado alto. El estudio de los pacientes durante un seguimiento de 5 años (n = 18) reveló que todos los tumores menos uno de grado bajo siguieron siendo superficiales sin progresión. Estos tumores eran bcl-2+/p53-, mientras que el único con inmunofenotipo bcl-2+/p53+ progresó hasta convertirse en un tumor de bajo grado ulcerado tras la desaparición de Helicobacter pylori. Se observó una regresión completa en 6 de los 8 pacientes del grupo no tratado con cirugía (n = 8) tras la erradicación de Helicobacter pylori. Estos tumores eran superficiales, de bajo grado, con ganglios negativos y bcl-2+/p53 no concluyente (n = 2); superficiales, de bajo grado, con ganglios negativos y bcl-2+/p53- (n = 2), y ulcerativos, de grado alto, con ganglios negativos y bcl-2+/p53- (n = 2). Los dos tumores persistentes eran ulcerativos, de grado alto con ganglios negativos y bcl-2+/p53+. Conclusión: el linfoma gástrico de tipo MALT, Helicobacter pylori-positivo, superficial, de grado bajo y bcl-2+/p53- desaparece tras la erradicación de Helicobacter pylori. Abstract in english Aim: it is doubtful that whoever is suffering from gastric malt lymphoma will escape from the disease, if treated with medication against helicobacter pylori. Material and methods: a cohort of 18 patients was analysed. Ten hosts had primary gastric malt lymphoma and were treated with gastric resecti [...] on as the initial therapy. Eight hosts received antibiotics against Helicobacter pylori as the initial treatment. In all 18 patients Helicobacter pylori status, endoscopic findings and pathology features were evaluated. Immunohistochemistry was performed to assess the bcl-2 and p53 status. Results: patients with low grade malt lymphoma: a) were Helicobacter pylori positive (5 of 5); b) had a superficial lesion (5 of 5); c) had no lymph node involvement (5 of 5); and d) were downstaged by comparison to patients with high grade tumor. Bcl-2 was positive in 4 of 5 low grade tumors, and p53 was positive in 12 of 13 high grade ones. Investigation of patients with 5-year follow up (n = 18) revealed that all but one low-grade tumors remained superficial with no progression. These tumors were bcl-2+/p53-, and the one with a bcl-2+/p53+ immunophenotype progressed to an ulcerated low-grade tumor after disappearance of Helicobacter pylori. Complete regression was found in 6 of 8 patients from the non surgically treated group (n = 8) after Helicobacter pylori eradication. These tumors were superficial/low grade/node negative/bcl-2+/p53 inconclusive (n = 2), superficial/low grade/node negative/bcl-2+/p53- (n = 2), and ulcerative/high grade/node negative/bcl-2+/p53- (n = 2). The two persistent tumors were ulcerative/high grade/node negative/bcl-2+/p53+. Conclusion: gastric malt lymphoma Helicobacter pylori+/superficial/low grade/bcl-2+/p53- will disappear after Helicobacter pylori eradication.

I., Venizelos; D., Tamiolakis; M., Lambropoulou; S., Bolioti; S., Nikolaidou; G., Alexiadis; N., Papadopoulos.

2007-05-01

194

Primary MALT lymphomas of the stomach: A pathological study of 18 cases Linfomas gástricos primarios tipo MALT: un estudio patológico de 18 casos  

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Full Text Available Aim: it is doubtful that whoever is suffering from gastric malt lymphoma will escape from the disease, if treated with medication against helicobacter pylori. Material and methods: a cohort of 18 patients was analysed. Ten hosts had primary gastric malt lymphoma and were treated with gastric resection as the initial therapy. Eight hosts received antibiotics against Helicobacter pylori as the initial treatment. In all 18 patients Helicobacter pylori status, endoscopic findings and pathology features were evaluated. Immunohistochemistry was performed to assess the bcl-2 and p53 status. Results: patients with low grade malt lymphoma: a were Helicobacter pylori positive (5 of 5; b had a superficial lesion (5 of 5; c had no lymph node involvement (5 of 5; and d were downstaged by comparison to patients with high grade tumor. Bcl-2 was positive in 4 of 5 low grade tumors, and p53 was positive in 12 of 13 high grade ones. Investigation of patients with 5-year follow up (n = 18 revealed that all but one low-grade tumors remained superficial with no progression. These tumors were bcl-2+/p53-, and the one with a bcl-2+/p53+ immunophenotype progressed to an ulcerated low-grade tumor after disappearance of Helicobacter pylori. Complete regression was found in 6 of 8 patients from the non surgically treated group (n = 8 after Helicobacter pylori eradication. These tumors were superficial/low grade/node negative/bcl-2+/p53 inconclusive (n = 2, superficial/low grade/node negative/bcl-2+/p53- (n = 2, and ulcerative/high grade/node negative/bcl-2+/p53- (n = 2. The two persistent tumors were ulcerative/high grade/node negative/bcl-2+/p53+. Conclusion: gastric malt lymphoma Helicobacter pylori+/superficial/low grade/bcl-2+/p53- will disappear after Helicobacter pylori eradication.Objetivo: es difícil que alguien que padezca un linfoma gástrico de tipo MALT pueda librarse de la enfermedad,... a menos que se le trate con medicación para Helicobacter pylori. Material y métodos: se analizó una cohorte de 18 pacientes. Diez huéspedes tenían linfoma gástrico de tipo MALT y se trataron con resección gástrica como tratamiento inicial. Ocho recibieron antibióticos frente a Helicobacter pylori como tratamiento inicial. En los 18 pacientes se evaluaron la presencia de Helicobacter pylori, los hallazgos endoscópicos y los rasgos patológicos. Se realizó una inmunohistoquímica para valorar el bcl-2 y el p53. Resultados: los pacientes con linfoma MALT de grado bajo: a dieron positivo a Helicobacter pylori (5 de 5; b tenían una lesión superficial (5 de 5; c no tenían afectados los ganglios linfáticos (5 de 5; y d se estadificaron a la baja por comparación con los pacientes con tumores de grado alto. El bcl-2 fue positivo en 4 de los 5 tumores de grado bajo y el p53 fue positivo en 12 de 13 de los de grado alto. El estudio de los pacientes durante un seguimiento de 5 años (n = 18 reveló que todos los tumores menos uno de grado bajo siguieron siendo superficiales sin progresión. Estos tumores eran bcl-2+/p53-, mientras que el único con inmunofenotipo bcl-2+/p53+ progresó hasta convertirse en un tumor de bajo grado ulcerado tras la desaparición de Helicobacter pylori. Se observó una regresión completa en 6 de los 8 pacientes del grupo no tratado con cirugía (n = 8 tras la erradicación de Helicobacter pylori. Estos tumores eran superficiales, de bajo grado, con ganglios negativos y bcl-2+/p53 no concluyente (n = 2; superficiales, de bajo grado, con ganglios negativos y bcl-2+/p53- (n = 2, y ulcerativos, de grado alto, con ganglios negativos y bcl-2+/p53- (n = 2. Los dos tumores persistentes eran ulcerativos, de grado alto con ganglios negativos y bcl-2+/p53+. Conclusión: el linfoma gástrico de tipo MALT, Helicobacter pylori-positivo, superficial, de grado bajo y bcl-2+/p53- desaparece tras la erradicación de Helicobacter pylori.

I. Venizelos

2007-05-01

195

Burkitt's lymphoma of the duodenum in a patient with AIDS Linfoma de Burkitt do duodeno em um paciente com AIDS  

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Full Text Available Non-Hodgkin's lymphoma of B-cell type is the second most common neoplasm after Kaposi's sarcoma, among patients with human immunodeficiency virus infection. Most non-Hodgkin's lymphoma cases that are associated with acquired immunodeficiency syndrome involve extranodal sites, especially the digestive tract and the central nervous system. We report a case of primary lymphoma of the duodenum in a patient with AIDS. Upper gastrointestinal endoscopy revealed pseudopolypoid masses found in the second portion of the duodenum. A complete diagnostic study including histological, immunohistochemical and virological analyses showed high-grade B-cell Burkitt's lymphoma. The Epstein-Barr virus genome was detected in biopsies by immunohistochemical and in situ hybridization.O linfoma não-Hodgkin de células B é a segunda neoplasia mais comum em pacientes com infecção pelo vírus da imunodeficiência humana depois do sarcoma de Kaposi. A maioria dos casos de linfoma não-Hodgkin associados com a síndrome da imunodeficiência adquirida envolve locais extraganglionares, especialmente o trato digestivo e o sistema nervoso central. Nós relatamos um caso de linfoma primário do duodeno em um paciente com AIDS. Uma endoscopia digestiva alta mostrou massas pseudopolipóides encontradas na segunda porção do duodeno. Um estudo diagnóstico completo incluindo exames histológicos, imunohistoquímicos e virológicos mostrou um linfoma de células B tipo Burkitt. Detectou-se genoma do vírus Epstein-Barr em biópsias por hibridização in situ e imuno-histoquímica.

Marcelo Corti

2007-06-01

196

Burkitt's lymphoma of the duodenum in a patient with AIDS / Linfoma de Burkitt do duodeno em um paciente com AIDS  

Scientific Electronic Library Online (English)

Full Text Available O linfoma não-Hodgkin de células B é a segunda neoplasia mais comum em pacientes com infecção pelo vírus da imunodeficiência humana depois do sarcoma de Kaposi. A maioria dos casos de linfoma não-Hodgkin associados com a síndrome da imunodeficiência adquirida envolve locais extraganglionares, especi [...] almente o trato digestivo e o sistema nervoso central. Nós relatamos um caso de linfoma primário do duodeno em um paciente com AIDS. Uma endoscopia digestiva alta mostrou massas pseudopolipóides encontradas na segunda porção do duodeno. Um estudo diagnóstico completo incluindo exames histológicos, imunohistoquímicos e virológicos mostrou um linfoma de células B tipo Burkitt. Detectou-se genoma do vírus Epstein-Barr em biópsias por hibridização in situ e imuno-histoquímica. Abstract in english Non-Hodgkin's lymphoma of B-cell type is the second most common neoplasm after Kaposi's sarcoma, among patients with human immunodeficiency virus infection. Most non-Hodgkin's lymphoma cases that are associated with acquired immunodeficiency syndrome involve extranodal sites, especially the digestiv [...] e tract and the central nervous system. We report a case of primary lymphoma of the duodenum in a patient with AIDS. Upper gastrointestinal endoscopy revealed pseudopolypoid masses found in the second portion of the duodenum. A complete diagnostic study including histological, immunohistochemical and virological analyses showed high-grade B-cell Burkitt's lymphoma. The Epstein-Barr virus genome was detected in biopsies by immunohistochemical and in situ hybridization.

Marcelo, Corti; María Florencia, Villafañe; Liliana, Souto; Ricardo, Schtirbu; Marina, Narbaitz; Marcela de Dios, Soler.

2007-06-01

197

Linfoma de Células del Manto en un Canino: Reporte de Caso / Mantle cell lymphoma in a canine: Case report  

Scientific Electronic Library Online (English)

Full Text Available SciELO Peru | Language: Spanish Abstract in spanish Se describe el caso de un canino Staffordshire Terrier macho, de 11 años, con linfoma esplénico de tipo células del manto, proceso neoplásico hematopoyético de presentación rara [...] Abstract in english A case of splenic mantle cell hematopoietic neoplasia in a male Staffordshire Terrier dog, 11 years old, is described [...

Víctor, Puicón N; Nieves Sandoval, C; Diego Díaz, C; Vladimir, Aguilar; Luis, Tabacchi N; Jacqueline, Cahua U.

2014-12-01

198

Do current indications for surgery of primary gastric lymphoma exist? / ¿Existen indicaciones actuales para la cirugía en el linfoma gástrico?  

Scientific Electronic Library Online (English)

Full Text Available Objetivo: analizar los resultados de nuestra serie a fin de establecer si la extirpación quirúrgica continúa siendo una opción terapéutica válida para las situaciones en las que pudiera precisarse cirugía. Como objetivo secundario, analizar la prevalencia de infección por Helicobacter pylori. Pacien [...] tes y método: estudio retrospectivo de 69 pacientes consecutivos diagnosticados de linfoma gástrico primario, en estadio I E y II E de Ann Arbor, 65 de los cuales fueron tratados mediante gastrectomía entre 1974 y 1999. Edad media: 62,6 años (28-85). En 60 casos se revisó la histología de la pieza de resección con nuevas tinciones (hematoxilina-eosina, Giemsa), y estudio inmunohistoquímico de los bloques de parafina. La clasificación histológica se realizó de acuerdo con la clasificación de Isaacson. El análisis estadístico se realizó mediante las pruebas de Chi cuadrado y prueba exacta de Fisher y Kaplan-Meier y Log-Rank para el análisis de supervivencia. Resultados: la mortalidad fue de 9,2%. Se produjeron complicaciones no mortales en 10,8%. Se identificó Helicobacter pylori en 62,7%. Se produjo recaída en 7 pacientes (11,9%). La probabilidad de supervivencia fue de 87% a 5 años. El análisis estadístico no demostró influencia del estadio de Ann Arbor, invasión en la pared gástrica, infección por Helicobacter pylori, tipo histológico, ni afectación de bordes sobre la supervivencia. Conclusiones: la extirpación quirúrgica posibilita un alto grado de remisión completa y una excelente supervivencia a largo plazo, con mortalidad aceptable, por lo que es un tratamiento válido en caso de ausencia de diagnóstico histológico, hallazgo incidental o urgencia. Abstract in english Objective: to analyze the results of our series in order to assess whether surgical excision is still a valid therapeutic option in case the patient needs surgery. Secondarily, to analyze Helicobacter pylori infection rate. Patients and method: a retrospective study of 69 consecutive patients having [...] stage IE-IIE primary gastric lymphoma; of these, 65 were treated by gastrectomy between 1974 and 1999. Mean age: 62.6 years (28-85). New staining of paraffin-embedded samples from the surgical specimen were carried out (hematoxiline-eosine, Giemsa, immunohistochemistry) and reviewed. The histological classification was performed according to Isaacson's criteria. The statistical analysis was done by Chi-squared and Fisher's exact tests, as well as Kaplan-Meier and Log-Rank tests. Results: mortality was 9.2%. There were non-fatal complications in 10.8%. Helicobacter pylori was identified in 62.7%. Seven patients (11.9%) suffered a relapse. The 5-year survival probability was 87%. The statistical analysis did not show any influences of Ann Arbor stage, gastric wall invasion, Helicobacter pylori infection, histological type, or margin resection involvement on survival. Conclusions: surgical excision provides a high rate of complete remissions and excellent long-term survival with acceptable mortality. Therefore it appears to be a valid treatment in case of emergency surgery, incidental finding, or lack of histological diagnosis.

J. C., Rodríguez-Sanjuán; R. A., García; S., Trugeda; F. de la, Torre; J., Llorca; M., Gómez-Fleitas.

2006-03-01

199

Do current indications for surgery of primary gastric lymphoma exist? ¿Existen indicaciones actuales para la cirugía en el linfoma gástrico?  

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Full Text Available Objective: to analyze the results of our series in order to assess whether surgical excision is still a valid therapeutic option in case the patient needs surgery. Secondarily, to analyze Helicobacter pylori infection rate. Patients and method: a retrospective study of 69 consecutive patients having stage IE-IIE primary gastric lymphoma; of these, 65 were treated by gastrectomy between 1974 and 1999. Mean age: 62.6 years (28-85. New staining of paraffin-embedded samples from the surgical specimen were carried out (hematoxiline-eosine, Giemsa, immunohistochemistry and reviewed. The histological classification was performed according to Isaacson's criteria. The statistical analysis was done by Chi-squared and Fisher's exact tests, as well as Kaplan-Meier and Log-Rank tests. Results: mortality was 9.2%. There were non-fatal complications in 10.8%. Helicobacter pylori was identified in 62.7%. Seven patients (11.9% suffered a relapse. The 5-year survival probability was 87%. The statistical analysis did not show any influences of Ann Arbor stage, gastric wall invasion, Helicobacter pylori infection, histological type, or margin resection involvement on survival. Conclusions: surgical excision provides a high rate of complete remissions and excellent long-term survival with acceptable mortality. Therefore it appears to be a valid treatment in case of emergency surgery, incidental finding, or lack of histological diagnosis.Objetivo: analizar los resultados de nuestra serie a fin de establecer si la extirpación quirúrgica continúa siendo una opción terapéutica válida para las situaciones en las que pudiera precisarse cirugía. Como objetivo secundario, analizar la prevalencia de infección por Helicobacter pylori. Pacientes y método: estudio retrospectivo de 69 pacientes consecutivos diagnosticados de linfoma gástrico primario, en estadio I E y II E de Ann Arbor, 65 de los cuales fueron tratados mediante gastrectomía entre 1974 y 1999. Edad media: 62,6 años (28-85. En 60 casos se revisó la histología de la pieza de resección con nuevas tinciones (hematoxilina-eosina, Giemsa, y estudio inmunohistoquímico de los bloques de parafina. La clasificación histológica se realizó de acuerdo con la clasificación de Isaacson. El análisis estadístico se realizó mediante las pruebas de Chi cuadrado y prueba exacta de Fisher y Kaplan-Meier y Log-Rank para el análisis de supervivencia. Resultados: la mortalidad fue de 9,2%. Se produjeron complicaciones no mortales en 10,8%. Se identificó Helicobacter pylori en 62,7%. Se produjo recaída en 7 pacientes (11,9%. La probabilidad de supervivencia fue de 87% a 5 años. El análisis estadístico no demostró influencia del estadio de Ann Arbor, invasión en la pared gástrica, infección por Helicobacter pylori, tipo histológico, ni afectación de bordes sobre la supervivencia. Conclusiones: la extirpación quirúrgica posibilita un alto grado de remisión completa y una excelente supervivencia a largo plazo, con mortalidad aceptable, por lo que es un tratamiento válido en caso de ausencia de diagnóstico histológico, hallazgo incidental o urgencia.

J. C. Rodríguez-Sanjuán

2006-03-01

200

Linfoma primario del sistema nervioso central en una paciente con lupus eritematoso sistémico  

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Full Text Available Se presenta una paciente de 36 años con diagnóstico de lupus eritematoso sistémico tratada con prednisona y ciclofosfamida que se internó por cefalea, hemiparesia y hemianestesia braquiocrural derecha de dos semanas de evolución. Se realizó una tomografía computada y una resonancia magnética nuclear de cerebro que mostraron una lesión nodular frontal izquierda. Se efectuó una biopsia a cielo abierto de la lesión cerebral cuyo diagnóstico histopatológico fue linfoma B de celulas grandes, difuso. Se inició radioterapia, no completó el tratamiento por complicaciones y falleció. Son muy pocos los casos publicados de linfoma primario del sistema nervioso central asociado a lupus eritematoso sistémico.A 36 year-old woman with systemic lupus erythematosus was admitted to our hospital with headache, brachiocrural hemiparesis and hemianesthesia. She had been treated with prednisone and cyclophosphamide. CT scan and MRI revealed a 15 mm nodular mass enhanced with gadolinium in left frontal convexity. CNS biopsy was performed and a diffuse large B-cell lymphoma was diagnosed. She was treated with radiation therapy without response and died. There are few reports of erythematosus systemic lupus associated with primary central nervous system lymphoma.

C. N. Pisoni

2003-06-01

201

La crítica de Hicks al Tratado del Dinero de Keynes  

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Full Text Available El objetivo de este artículo es mostrar que la crítica que hace Hicks al Tratado del Dinero de Keynes es incorrecta. Para ello, presentamos el modelo de Keynes, mostrando que la igualdad entre la inversión y el ahorro es una condición de equilibrio monetario y no una identidad. Este resultado no puede ser obtenido en el análisis de Hicks.

Alexander Tobón

2004-12-01

202

Linfoma canino: clínica, hematologia e tratamento com o protocolo de Madison-Wisconsin Canine lymphoma: clinical and hematological aspects and treatment with the Madison-Wisconsin protocol  

OpenAIRE

O linfoma é uma neoplasia de elevada incidência na população canina mundial, e que apresenta sinais clínicos diversos, dependentes da classificação anatômica e da extensão da doença. Este estudo objetivou avaliar as características clínicas e hematológicas de cães com linfoma no momento do diagnóstico, além da evolução clínica dos mesmos ao longo do tratamento com o protocolo de Madison-Wisconsin. Dos 18 cães inseridos no estudo, 50% apresentaram a forma multicêntrica da ...

Maria Luisa Buffo de Cápua; Flávia Eiras Dela Coleta; Ana Paula Massae Nakage Canesin; Aline Vieira Godoy; Sabryna Gouveia Calazans; Mariana Rodrigues Miotto; Carlos Roberto Daleck; Aureo Evangelista Santana

2011-01-01

203

Linfoma primario cutáneo difuso de células B grandes, tipo pierna (LPCDCBG-TP, localizado en cuero cabelludo Diffuse primary large B-Cell cutaneous lymphoma  

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Full Text Available Los linfomas primarios cutáneos de células B se consideran actualmente como categoría distintiva de los linfomas primarios cutáneos y se reconocen subtipos característicos dentro de ellos. Se presenta un caso de linfoma primario cutáneo difuso de células B grandes, tipo pierna, con localización en el cuero cabelludo, donde se pudo disponer de estudios inmunohistoquímicos para su tipificación, que mostraron positividad para los marcadores CD20, bcl-2 y MUM-1, y negatividad para CD3 y bcl-6. Estos resultados, unidos a las características de las lesiones y el estudio histológico condujeron al diagnóstico final.Los linfomas primarios cutáneos de células B se consideran actualmente como categoría distintiva de los linfomas primarios cutáneos y se reconocen subtipos característicos dentro de ellos. Se presenta un caso de linfoma primario cutáneo difuso de células B grandes, tipo pierna, con localización en el cuero cabelludo, donde se pudo disponer de estudios inmunohistoquímicos para su tipificación, que mostraron positividad para los marcadores CD20, bcl-2 y MUM-1, y negatividad para CD3 y bcl-6. Estos resultados, unidos a las características de las lesiones y el estudio histológico condujeron al diagnóstico final.

Oristel I Felipe Fereira

2010-06-01

204

Linfoma primario cutáneo difuso de células B grandes, tipo pierna (LPCDCBG-TP), localizado en cuero cabelludo / Diffuse primary large B-Cell cutaneous lymphoma  

Scientific Electronic Library Online (English)

Full Text Available Los linfomas primarios cutáneos de células B se consideran actualmente como categoría distintiva de los linfomas primarios cutáneos y se reconocen subtipos característicos dentro de ellos. Se presenta un caso de linfoma primario cutáneo difuso de células B grandes, tipo pierna, con localización en e [...] l cuero cabelludo, donde se pudo disponer de estudios inmunohistoquímicos para su tipificación, que mostraron positividad para los marcadores CD20, bcl-2 y MUM-1, y negatividad para CD3 y bcl-6. Estos resultados, unidos a las características de las lesiones y el estudio histológico condujeron al diagnóstico final. Abstract in english Los linfomas primarios cutáneos de células B se consideran actualmente como categoría distintiva de los linfomas primarios cutáneos y se reconocen subtipos característicos dentro de ellos. Se presenta un caso de linfoma primario cutáneo difuso de células B grandes, tipo pierna, con localización en e [...] l cuero cabelludo, donde se pudo disponer de estudios inmunohistoquímicos para su tipificación, que mostraron positividad para los marcadores CD20, bcl-2 y MUM-1, y negatividad para CD3 y bcl-6. Estos resultados, unidos a las características de las lesiones y el estudio histológico condujeron al diagnóstico final.

Oristel I, Felipe Fereira; Eugenio, Leonardo; Juan, Hernández Vázquez.

2010-06-01

205

Síndrome hemofagocítico y linfoma cutáneo de células T / Haemophagocytic syndrome and cutaneous T-cell lymphoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish El síndrome hemofagocítico (SHF) es un trastorno infrecuente de la inmunorregulación, cuyas manifestaciones clínicas son fiebre, hemofagocitosis, hepatoesplenomegalia, pancitopenia, linfadenopatías, hipertrigliceridemia y coagulopatía. Puede cursar también con afectación pulmonar, fracaso renal agud [...] o o síndrome de secreción inadecuada de ADH (SIADH). Se ha descrito asociado a múltiples enfermedades, destacando los linfomas, sobre todo de células T, infecciones y enfermedades sistémicas, entre otras entidades. Las células hematopoyéticas son fagocitadas por monocitos y macrófagos en los ganglios linfáticos, médula ósea, hígado y bazo, lo que constituye un criterio diagnóstico del SHF. El tratamiento es difícil e incluye medidas de soporte y de las alteraciones de coagulación así como corticoides sistémicos a altas dosis e inmunosupresores, aunque en la mayoría de ocasiones no hay respuesta al tratamiento y la evolución es fatal. Los linfomas T que afectan al tejido celular subcutáneo y simulan una paniculitis han sido clasificados recientemente como linfomas cutáneos de células T (LCCT), siendo infrecuente su presentación como nódulos inflamatorios en extremidades inferiores. Abstract in english Haemophagocytic syndrome is a rare disorder of immune regulation. Clinical features are fever, haemophagocytosis, hepatosplenomegaly, pancitopenia, lymph nodes enlargement, hypertriglyceridaemia and coagulopaty. Systemic findings may also include pulmonary infiltrates, renal failure and an inappropr [...] iate antidiuretic state. It has been described associated to many diseases, like lymphomas, most of them T-cell lymphomas, infections and systemic diseases, among other entities. Haemopoietic cells are actively ingested by monocites and macro-phages in lymph nodes, bone marrow, liver and spleen. This is a diagnostic criteria for haemophagocytic syndrome. The treatment of Haemophagocytic syndrome is difficult and requires intensive supportive therapy, treatment of coagulopaty disorders, high-dose corticosteroids and immunosuppressive treatment, although in most cases there is no response to treatment and the evolution is fatal. The T-cell lymphomas that involve subcutaneous tissue and simulate panniculitis are classified recently as primary cutaneous T-cell lymphomas, and their presentation as inflammatory nodules of the legs are uncommon.

A., Artigues Barceló; M., Ferragut Reus; C., Sánchez; I., Amengual; I., Matanza; M. S., Sanz Parras.

2004-03-01

206

The ultrasonic appearance of intravascular gas in fetal death.  

Science.gov (United States)

Real-time ultrasonography permits an accurate diagnosis of intrauterine fetal death by documenting absent cardiac motion. Occasionally, intravascular and/or intracardiac gas arises from maceration following fetal demise. The presence of gas in the heart and circulatory system alters the ultrasonic appearance of the fetal body. What may appear to be technically poor visualization of the fetus secondary to tissue maceration, oligohydramnios, or maternal factors may, in fact, be due to reverberation artifacts produced by intravascular gas. These characteristic echogenic foci have been radiographically proven to represent intrafetal gas. Recognition of the appearance of gas in the circulatory system is important since gas is a pathognomonic sign of fetal death. PMID:6632058

Weinstein, B J; Platt, L D

1983-10-01

207

Intravascular photoacoustic tomography for characterization of atherosclerotic lipid and inflammation  

Science.gov (United States)

Photoacoustic imaging is a fast growing imaging technology depending on its high optical resolution of optics while taking the advantage of the high penetration depth of ultrasound. In this paper, we demonstrate the new progress in the photoacoustic imaging. Atherosclerosis is characterized by a progressive build-up of lipid in the arterial wall, which is known as plaque. Histological studies demonstrate that the primary cause of acute cardiovascular events is the rupture of atherosclerotic plaques. Lipid and inflammation within the plaque are related to influence the propensity of plaques to disrupt. Photoacoustic intravascular tomography (IVPAT) holds a great advantage in providing comprehensive morphological and functional information of plaques. Lipid relative concentration maps of atherosclerotic aorta were obtained and compared with histology. Furthermore, by selectively targeting the intravascular inflammatory cytokines, IVPAT is also capable of mapping the inflamed area and determining the degree of inflammation.

Zhang, Jian; Qin, Huan; Shi, Yujiao; Yang, Sihua; Xing, Da

2014-09-01

208

Intravascular photoacoustic imaging of gold nanorod-labeled atherosclerotic plaques  

Science.gov (United States)

Combined intravascular photoacoustic (IVPA) and intravascular ultrasound (IVUS) imaging has been previously established as a viable means for imaging atherosclerotic plaques using both endogenous and exogenous contrast. In this study, IVUS/IVPA imaging of an atherosclerotic rabbit aorta following injection of gold nanorods (AuNR) with peak absorbance within the tissue optical window was performed. Ex-vivo imaging results revealed high photoacoustic signal from localized AuNR. Corresponding histological cross-sections and digital photographs of the artery lumen confirmed the presence of AuNR preferentially located at atherosclerotic regions and in agreement with IVPA signal. Furthermore, an integrated IVUS/IVPA imaging catheter was used to image the AuNR in the presence of luminal blood. The results suggest that AuNR allow for IVPA imaging of exogenously labeled atherosclerotic plaques with a comparatively low background signal and without the need for arterial flushing.

Yeager, Doug; Karpiouk, Andrei; Wang, Bo; Amirian, James; Sokolov, Konstantin; Smalling, Richard; Emelianov, Stanislav

2012-02-01

209

Intravascular optical coherence tomography on a beating heart model  

Science.gov (United States)

The advantages and limitations of using a beating heart model in the development of intravascular optical coherence tomography are discussed. The model fills the gap between bench experiments, performed on phantoms and excised arteries, and whole animal in-vivo preparations. The beating heart model is stable for many hours, allowing for extended measurement times and multiple imaging sessions under in-vivo conditions without the complications of maintaining whole-animal preparation. The perfusate supplying the heart with nutrients can be switched between light scattering blood to a nonscattering perfusate to allow the optical system to be optimized without the need of an efficient blood displacement strategy. Direct access to the coronary vessels means that there is no need for x-ray fluoroscopic guidance of the catheter to the heart, as is the case in whole animal preparation. The model proves to be a valuable asset in the development of our intravascular optical coherence tomography technology.

Lamouche, Guy; Dufour, Marc; Hewko, Mark; Vergnole, Sébastien; Gauthier, Bruno; Bisaillon, Charles-Étienne; Monchalin, Jean-Pierre; Sowa, Michael G.

2010-07-01

210

[Morphologic aspects of intravascular disseminated coagulation. Apropos of 100 cases].  

Science.gov (United States)

The authors report a morphological study of one hundred cases of disseminated intravascular coagulation (D.I.C.) of various origins. In each case laboratory findings demonstrated an authentic consumption coagulopathy. In all cases organ biopsies were performed either in vitro (rarely), or mainly immediately after death or at autopsy. Optic microscopy was performed for all of them (3 stains were chosen: hemalum eosin saffron, Mallory's phosphotungstic acid hematoxylin stain, P.A.S.). For a smaller number of cases ultrastructural microscopy and immunofluorescence were performed. As far as microscopic findings are concerned, the authors insist particularly upon intravascular microthrombi (fibrinous type and hyalin type). Haemorrhages and particularly necrosis, because of multiple origin, are not detailed. The repartition of these microthrombi is particularly detailed (in connection with the different organs, etiologies, clinical and/or biological findings, treatments). A review of literature is reported. PMID:6354203

Gerard, A; Lambert, H; Larcan, A; Rauber, G

1983-09-01

211

A hybrid plaque characterization method using intravascular ultrasound images  

OpenAIRE

Intravascular ultrasound (IVUS) is an invasive imaging modality that provides high resolution crosssectional images permitting detailed evaluation of the lumen, outer vessel wall and plaque morphology and evaluation of its composition. Over the last years several methodologies have been proposed which automated processing of the IVUS data and reliable segmentation of the regions of interest or characterization of the type of the plaque. In this paper we present a novel methodology for the aut...

Athanasiou, Lambros S.; Karvelis, Petros S.; Sakellarios, Antonis; Exarchos, Themis; Siogkas, Panagiotis K.; Tsakanikas, Vassilis D.; Naka, Katerina K.; Bourantas, Christos V.; Papafaklis, Michail I.; Koutsouri, Georgia; Michalis, Lampros K.; Parodi, Oberdan; Fotiadis, Dimitrios I.

2013-01-01

212

Avascular necrosis of the midface secondary to disseminated intravascular coagulation.  

Science.gov (United States)

To the authors' knowledge, avascular necrosis of the midface secondary to disseminated intravascular coagulation has yet to be described following a hypoxic syncopal episode secondary to 'heat stroke'. A slow, progressive loss of anterior maxillary bone and the collapse of the nasal dorsum in a healthy young man with no other known medical co-morbidities led to the diagnosis. Following debridement, a staged reconstruction of the maxilla-nasal complex was successfully performed. PMID:25444482

Nguyen, E V; Heggie, A A C

2014-12-01

213

MR image guidance and flow monitoring of intravascular interventions  

OpenAIRE

The research described in this thesis was performed within the context of the “Utrecht interventional MRI project”. At the start of the project, the use of MRI guidance particularly in intravascular interventions was limited to merely experimental studies. The reason for this was the lack of safe MR-dedicated catheters and guidewires and the fact that commercially available MRI scanners did not provide the functionality required for guiding the interventionalist. The aim of the project wa...

Weide, R.

2001-01-01

214

Status Epilepticus as the Initial Presentation of Intravascular Lymphoma  

OpenAIRE

Intravascular lymphoma (IVL) is a rare disease form of malignant lymphoma, and it is characterised by the selective growth of lymphoma cells within the lumina of vessels. Identification of this disease at an early stage is difficult because of non-specific clinical symptoms and neuroradiological findings. Most reported IVL cases are diagnosed at post-mortem following autopsy. We report the case of a patient who presented with status epilepticus (SE) as the initial manifestation of IVL. Despit...

Hiraga, Akiyuki; Ozaki, Daisuke; Kamitsukasa, Ikuo; Araki, Nobuyuki; Arai, Kimihito

2012-01-01

215

Tissue characterisation from intravascular ultrasound using texture analysis  

OpenAIRE

Intravascular ultrasound has, over the past decade, significantly changed the clinical diagnosis and therapeutic strategy of coronary and vascular disease assessment, as it not only allows visualisation of the vessel lumen, but gives a unique view of the pathophysiologic structure of the artery wall. This information is currently unavailable from the universally accepted instrument for artery assessment, angiography, which has on several occasions had its diagnostic accuracy qu...

Nailon, William H.

1997-01-01

216

Mechanotransductional Basis of Endothelial Cell Response to Intravascular Bubbles  

OpenAIRE

Vascular air embolism resulting from too rapid decompression is a well-known risk in deep-sea diving, aviation and space travel. It is also a common complication during surgery or other medical procedures when air or other endogenously administered gas is entrained in the circulation. Preventive and post-event treatment options are extremely limited for this dangerous condition, and none of them address the poorly understood pathophysiology of endothelial response to intravascular bubble pres...

Klinger, Alexandra L.; Pichette, Benjamin; Sobolewski, Peter; Eckmann, David M.

2011-01-01

217

Intravascular Ultrasound in Percutaneous Coronary Intervention for Chronic Total Occlusion  

OpenAIRE

Background: Percutaneous coronary intervention (PCI) of chronic total occlusion (CTO) is one of the most challenging procedures in interventional cardiology. New techniques and devices have made possible to face these complex procedures. Intravascular ultrasound (IVUS) reveals special features and contributes greatly to procedural success.Method: We analysed retrospectively IVUS contribution and findings in 23 cases of a total 46 CTOs PCI from February 2009 to August 2010 in our cath lab. Bot...

Mohandes, M.; Guarinos, J.; Sans, J.; Bardaji, A.

2010-01-01

218

Intravascular Stent Therapy for Coarctation of the Aorta  

OpenAIRE

Intravascular stent therapy is considered a primary therapeutic option for most adults and adolescents with coarctation of the aorta. This review highlights the indications, technical considerations, procedural aspects, and limited long-term outcome data when using this intervention. Stent technology has continued to evolve with potential for further modifications since its inception in the early 1990s. The best therapeutic approach, e.g., stenting versus surgery, in the treatment of native c...

Forbes, Thomas J.; Gowda, Srinath T.

2014-01-01

219

SEPSIS-ASSOCIATED DISSEMINATED INTRAVASCULAR COAGULATION AND THROMBOEMBOLIC DISEASE  

OpenAIRE

Sepsis is almost invariably associated with haemostatic abnormalities ranging from subclinical activation of blood coagulation (hypercoagulability), which may contribute to localized venous thromboembolism, to acute disseminated intravascular coagulation (DIC), characterized by massive thrombin format...

Ammollo, Concetta T.; Nicola Semeraro; Fabrizio Semeraro; Mario Colucci

2010-01-01

220

Disseminated intravascular coagulation complicating HELLP syndrome: perioperative management  

OpenAIRE

HELLP syndrome may lead to disseminated intravascular coagulation (DIC) which can make emergency surgery a serious challenge. A 29-year-old female presented with haematuria, epistaxis and hypertension in the emergency ward and a diagnosis of DIC complicating HELLP in preeclampsia was made. She had continuous epistaxis and elective tracheal intubation was carried out. During emergency caesarean section the patient was managed with blood products, antihypertensive drugs and general anaesthesia ...

Garg, Rakesh; Nath, M. P.; Bhalla, A. P.; Kumar, Ashwani

2009-01-01

221

Disseminated intravascular coagulation after isolated mild head injury.  

OpenAIRE

A rare case is described of acute disseminated intravascular coagulation (DIC) following isolated mild head injury with acute subdural haematoma, coagulopathy onset preceding craniotomy. Surgical treatment of the cause followed by swift diagnosis and treatment soon after surgery enabled a good outcome. Post-operative recollection of subdural and extadural blood was treated by further surgery. DIC following isolated mild head injury without axonal damage is rare, but fatal if missed. Thrombocy...

Pereira, Ea; Green, Al; Chandran, H.; Joshi, Sm; Shlugman, D.; Cudlip, Sa

2009-01-01

222

Disseminated Intravascular Coagulation syndrome — ENT surgeon’s perspective  

OpenAIRE

ENT surgeon is seldom confronted with a systemic disease severe enough to progress to Disseminated Intravascular Coagulation syndrome (DIC), where he has to undertake a definitive surgical procedure for malignancy or perform an emergency tracheostomy. This calls for a judicious calculation of the pros and cons with an element of risk that needs to be accepted. We report two such patients who have been treated in such a scenario where the outcome varied depending on the severity and time of on...

Ravikumar, A.; Sasindran, Vivek; Senthil, K.; Samuel, John; Thirumaran

2006-01-01

223

Plasma Factor XIII Activity in Patients with Disseminated Intravascular Coagulation  

OpenAIRE

The objective of this study was to investigate the correlation between factor XIII (FXIII) activity and disseminated intravascular coagulation (DIC) parameters and also to evaluate the clinical usefulness of DIC diagnosis. Citrated plasma from eighty patients with potential DIC was analyzed for FXIII activity. The primary patient conditions (48 male and 32 female, mean age, 51 years) were malignancy (n = 29), infection (n = 25), inflammation (n = 6), heart disease (n = 3), thrombosis (n = 2),...

Song, Jae Woo; Choi, Jong Rak; Song, Kyung Soon; Rhee, Ji-hyuk

2006-01-01

224

Liver abscess and disseminated intravascular coagulation in tuberculosis.  

OpenAIRE

We report the case of a 55-year-old man with chronic renal failure, and a history of prolonged fever and jaundice. Radiological studies revealed a multiloculated irregular liver abscess. Mycobacterium tuberculosis was isolated from the abscess on smear and culture of aspirated pus. Haematological studies revealed the presence of disseminated intravascular coagulation. A detailed search failed to identify any reason for this other than the tuberculous infection. The treatment of tuberculous li...

Nampoory, M. R.; Halim, M. M.; Sreedharan, R.; Al-sweih, N. A.; Gupta, R. K.; Constandi, J. N.; Johny, K. V.

1995-01-01

225

Disseminated intravascular coagulation, antiphospholipid antibodies, and ischaemic necrosis of extremities.  

OpenAIRE

A middle aged woman presented with acute, severe, intravascular coagulation leading to ischaemic necrosis of the extremities. Pulmonary involvement required artificial ventilation, and there was evidence of hepatic, pancreatic, and renal damage, which resolved without complication. These events may have been triggered by the ingestion of compound diuretic tablets. The finding of the 'lupus anticoagulant' and anticardiolipin antibodies, together with high titre antinuclear factor in the serum,...

Bird, A. G.; Lendrum, R.; Asherson, R. A.; Hughes, G. R.

1987-01-01

226

Classifying types of disseminated intravascular coagulation: clinical and animal models  

OpenAIRE

Disseminated intravascular coagulation (DIC) has a common pathogenesis in terms of persistent widespread activation of coagulation in the presence of underlying disease, but the degree of fibrinolytic activation often differs by DIC type. DIC with suppressed fibrinolysis is a DIC type usually seen in sepsis. Coagulation activation is severe, but fibrinolytic activation is mild. DIC with enhanced fibrinolysis is a DIC type usually seen in acute promyelocytic leukemia (APL). Both coagulation ac...

Asakura, Hidesaku

2014-01-01

227

Pulmonary infarction, myocardial infarction, and acute disseminated intravascular coagulation.  

OpenAIRE

Pulmonary and myocardial damage are frequently cited as manifestations of disseminated intravascular coagulation (DIC), but rarely as causes. Three elderly cases of severe DIC due to pulmonary and myocardial infarction are reported. All three patients died. Necropsy showed extensive pulmonary emboli in each case with large pulmonary infarcts in cases 1 and 2 and a ventricular aneurysm containing thrombus in cases 2 and 3. Early diagnosis and treatment of pulmonary embolism requires a high deg...

Thomson, F. J.; Benbow, E. W.; Mcmahon, R. F.; Cheshire, C. M.

1991-01-01

228

Disseminated Intravascular Coagulation with Acutely-Thrombosed Popliteal Aneurysm  

OpenAIRE

Disseminated intravascular coagulation (DIC) is an extremely rare complication of acute thrombosis in popliteal aneurysms and makes it difficult to restore the blood flow with thrombolytic therapy or surgical repair. A 75-year-old man with a history of hypertension presented to the emergency department with complaints of right leg pain and bleeding tendency over a 5-day period. The laboratory findings and multislice computed tomography were suggestive of overt DIC caused by acute thrombosis i...

Ichibori, Yasuhiro; Shintani, Hideo; Okuhara, Yoshitaka; Shibamoto, Masato; Yoshida, Akira; Sato, Fumi; Yamada, Takayuki; Hatsuoka, Shinichi

2010-01-01

229

Optimization of intravascular brachytherapy treatment planning in peripheral arteries.  

OpenAIRE

This work deals with the treatment planning optimization for intravascular brachytherapy (IVB) in peripheral arteries. The objective is both to quantitatively study the validity of different hypotheses required for a reliable application of the treatment with current techniques, and to contribute to the definition and the specification of a new optimized procedure taking into account the actual patient's vessel geometry. The detection of vascular luminal surface was performed by an image anal...

Zhou, Zhengdong; Haigron, Pascal; Shu, Huazhong; Yu, Wenxue; Moisan, Ce?cile; Manens, Jean-pierre; Lucas, Antoine; Luo, Limin

2007-01-01

230

A study of intravascular brachytherapy treatment planning in peripheral arteries  

OpenAIRE

A two-step method to determine the seed parameters for the planning of peripheral intravascular brachytherapy, which took the actual vessel geometry into consideration, was developed. Firstly, the characteristics of the vessel geometry was obtained by using active navigation; Then a method combined genetic algorithm with BFGS algorithm was applied to optimize the number of seeds, and the parameters associated with each seed such as the position, and the dwell time. Application of the method t...

Zhou, Zhengdong; Haigron, Pascal; Acosta, Oscar; Shu, Huazhong; Yu, Wenxue; Luo, Limin; Manens, Jean-pierre; Lucas, Antoine

2005-01-01

231

The Role of Intravascular Ultrasound in Venous Thromboembolism  

OpenAIRE

Venous thromboembolism (VTE) remains a serious problem, and treatments surrounding this potentially life-threatening disease continue to evolve. Evidence-based guidelines purport the need for minimally invasive catheter-based procedures as part of the armamentarium to prevent and treat VTE. When the appropriate clinical scenarios arise, intravascular ultrasound (IVUS) becomes a necessary part of those procedures to provide alternative imaging that complements traditional venography. IVUS of t...

Mclafferty, Robert B.

2012-01-01

232

A novel ionization chamber for dosimetry in intravascular brachytherapy  

International Nuclear Information System (INIS)

A novel ionization chamber for the dosimetry and quality assurance program of beta particle emitting radioactive sources (in the form of wires or seed trains) used in the intravascular brachytherapy of coronary disease has been devised and investigated. It has a cylindrical shape, and a catheter, housing the source (a wire or seeds), passes through the chamber along its axis. The new type of ionization chamber is called the ring ionization chamber (RIC). Owing to its similarity to a cylindrical ionization chamber, the well-established dosimetric protocol can be applied to determine the absorbed dose-to-air chamber calibration factor, ND, as well as the absorbed dose-to-water calibration factor, ND,W. Owing to this similarity, the overall uncertainty in the standardization of the absorbed dose for beta radioactive sources used in intravascular brachytherapy could be substantially reduced compared with that presently achieved. The RIC can be implemented into a new code of practice for dose standardization and quality assurance in intravascular brachytherapy. An example of practical application of a model of RIC for dosimetry of 32P radioactive source is presented

233

Linfomas em pacientes com a forma hepatoesplênica da esquistossomose mansônica / Lymphoma in patients harboring hepatosplenic mansonic schistosomiasis  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese RACIONAL: Cada vez mais se estabelece a correlação entre agentes infecciosos e doenças linfoproliferativas, sobretudo vírus e bactérias, através da ativação de linfócitos. OBJETIVO: Descrever 6 novos casos, de uma série de 254 pacientes (2,36%) com esquistossomose mansônica na forma hepatoesplênica. [...] CASUÍSTICA E MÉTODOS: São descritos 6 pacientes, dentre os 254 portadores de esquistossomose mansônica na forma hepatoesplênica, acompanhados nos últimos 13 anos no Serviço de Cirurgia Geral do Hospital das Clínicas da Universidade Federal de Pernambuco, Recife, PE. RESULTADOS: Todos os seis casos ocorreram em mulheres. Os exames histopatológicos evidenciaram dois casos de linfomas de zona marginal esplênica, um de linfoma de grandes células com imunoblastos, um de linfoma difuso de grandes células, um de linfoma maligno de grandes células não clivadas, e um outro caso de doença de Hodgkin. Metade das seis pacientes evoluiu para o óbito entre 4 a 15 meses após o diagnóstico. As outras três persistem em acompanhamento no Serviço de Oncologia da mesma instituição. CONCLUSÃO: A incidência de linfoma nos 254 pacientes acompanhados foi de 2,36%. Pretende-se chamar a atenção para a ocorrência de linfomas nos baços de pacientes com esquistossomose mansônica, na forma hepatoesplênica. Abstract in english BACKGROUND: Correlation between infectious agents and linfoproliferative diseases are more stablished, over all virus and bacteria, through the activation of linfocytes. AIM: To describe six new cases, of a series of 254 patients (2,36%) with mansonic schistosomiasis, in the hepatosplenic form. METH [...] ODS: Six patients will be described, amongst the 254 carriers of mansonic schistosomiasis, in the hepatosplenic form, followed in the last 13 years. RESULTS: All the six cases had occurred in women. The histopathologic examinations had evidenced two cases of marginal splenic zone lymphomas, one of great cells with immunoblasts lymphomas, one diffuse lymphomas, a great cells malignant lymphomas, a great not clivads cells, and another case of Hodgkin. Half of the six evolved for the death 4-15 months after the diagnosis. The others three persist in accompaniment in the Oncology Division of the Clinics Hospital. CONCLUSION: The incidence of lymphomas in the 254 mansonic schistosomiasis patients followed in our clinic was of 2,36%. At last, this article intends to call the attention, for the occurrence of lymphomas, in the spleen of patients with mansonic schistosomiasis, in the hepatosplenic form.

Álvaro Antônio Bandeira, Ferraz; Vladimir Curvêlo Tavares de, Sá; Edmundo Pessoa de Almeida, Lopes; José Guido Corrêa de, Araújo Jr; Antônio Cavalcanti de Albuquerque, Martins; Edmundo Machado, Ferraz.

2006-06-01

234

Linfomas em pacientes com a forma hepatoesplênica da esquistossomose mansônica Lymphoma in patients harboring hepatosplenic mansonic schistosomiasis  

Directory of Open Access Journals (Sweden)

Full Text Available RACIONAL: Cada vez mais se estabelece a correlação entre agentes infecciosos e doenças linfoproliferativas, sobretudo vírus e bactérias, através da ativação de linfócitos. OBJETIVO: Descrever 6 novos casos, de uma série de 254 pacientes (2,36% com esquistossomose mansônica na forma hepatoesplênica. CASUÍSTICA E MÉTODOS: São descritos 6 pacientes, dentre os 254 portadores de esquistossomose mansônica na forma hepatoesplênica, acompanhados nos últimos 13 anos no Serviço de Cirurgia Geral do Hospital das Clínicas da Universidade Federal de Pernambuco, Recife, PE. RESULTADOS: Todos os seis casos ocorreram em mulheres. Os exames histopatológicos evidenciaram dois casos de linfomas de zona marginal esplênica, um de linfoma de grandes células com imunoblastos, um de linfoma difuso de grandes células, um de linfoma maligno de grandes células não clivadas, e um outro caso de doença de Hodgkin. Metade das seis pacientes evoluiu para o óbito entre 4 a 15 meses após o diagnóstico. As outras três persistem em acompanhamento no Serviço de Oncologia da mesma instituição. CONCLUSÃO: A incidência de linfoma nos 254 pacientes acompanhados foi de 2,36%. Pretende-se chamar a atenção para a ocorrência de linfomas nos baços de pacientes com esquistossomose mansônica, na forma hepatoesplênica.BACKGROUND: Correlation between infectious agents and linfoproliferative diseases are more stablished, over all virus and bacteria, through the activation of linfocytes. AIM: To describe six new cases, of a series of 254 patients (2,36% with mansonic schistosomiasis, in the hepatosplenic form. METHODS: Six patients will be described, amongst the 254 carriers of mansonic schistosomiasis, in the hepatosplenic form, followed in the last 13 years. RESULTS: All the six cases had occurred in women. The histopathologic examinations had evidenced two cases of marginal splenic zone lymphomas, one of great cells with immunoblasts lymphomas, one diffuse lymphomas, a great cells malignant lymphomas, a great not clivads cells, and another case of Hodgkin. Half of the six evolved for the death 4-15 months after the diagnosis. The others three persist in accompaniment in the Oncology Division of the Clinics Hospital. CONCLUSION: The incidence of lymphomas in the 254 mansonic schistosomiasis patients followed in our clinic was of 2,36%. At last, this article intends to call the attention, for the occurrence of lymphomas, in the spleen of patients with mansonic schistosomiasis, in the hepatosplenic form.

Álvaro Antônio Bandeira Ferraz

2006-06-01

235

Linfoma Extranodal de Células NK/T tipo Nasal / Extranodal Nasal type NK/T-Cell Lymphoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese O Linfoma Extranodal de Células NK/T tipo Nasal tem uma distribuição geográfica peculiar, ocorrendo mais frequentemente em países orientais e na população nativa de alguns países da América Central e da América do Sul. Sua localização preferencial é na cavidade nasal e nos seios paranasais, mas pode [...] acometer outras estruturas da chamada região médio-facial. Tem um padrão de disseminação com "homing" característico, incluindo pele, testículo, SNC e trato digestivo. Este linfoma, menos frequentemente, pode acometer primariamente estas regiões. A maioria destas neoplasias apresenta um fenótipo NK, mas alguns poucos casos podem ter sua origem em células T verdadeiras, por este motivo é designado "linfoma NK/T". O genoma do vírus Epstein-Barr é detectado na maioria dos casos, sugerindo uma relação etiológica. Embora este linfoma seja sensível à radioterapia, apresenta mais frequentemente resistência a agentes quimioterápicos que outros linfomas. Uma possível explicação para a resistência é a usual expressão de glicoproteína-p. O prognóstico destes linfomas é pobre, sendo necessária a investigação de novas modalidades terapêuticas. Abstract in english Extranodal Nasal type NK/T-Cell Lymphoma has a peculiar geographic distribution, occurring more frequently in Eastern countries and in the native populations of some Central and South American countries. It is commonly found in the nasal cavity and paranasal sinuses, but may also compromise other st [...] ructures in the mid-facial region. The disease has a characteristic homing dissemination pattern, including skin, testis, CNS and digestive tract. This lymphoma can, less frequently, primarily compromise these regions. The majority of these neoplastic diseases present an NK phenotype, but a few cases can be truly of T-cell origin, because of which it is designed "NK/T-cell lymphoma". The Epstein-Barr virus genome can be detected in most of the cases, suggesting an etiological relationship. Although this lymphoma is responsive to radiotherapy, it is more resistant to conventional chemotherapy than other lymphomas. A possible explanation for this is the frequent expression of the p-glycoprotein. The prognosis of these lymphomas is still poor, making further investigation of new therapies imperativ.

Carlos S., Chiattone.

2009-08-01

236

Psoriasis, lymphoma and etanercept: is there a correlation? / Psoríase, linfoma e etanercepte: existe correlação?  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese A psoríase é uma doença inflamatória crônica que pode afetar a pele e as articulações. Seu tratamento varia conforme a gravidade e inclui medicamentos tópicos e sistêmicos. Dentre os últimos estão os imunobiológicos, que têm como alvo a célula T. Relatamos um caso que demonstra a estreita relação en [...] tre a psoríase, o linfoma e os imunobiológicos. Abstract in english Psoriasis is a chronic inflammatory disease that can affect skin and joints. Their treatment varies depending on the severity and includes topical and systemic. Among the latter are the immunobiological that target the T cell We report a case that demonstrates the close relationship between psoriasi [...] s, lymphoma and biologic therapies.

Ludmilla Queirós, Miranda; Aline Lopes, Bressan; Fernanda Valente da Silva, Rehfeldt; Bárbara Nader, Vasconcelos; Alexandre Carlos, Gripp.

2012-02-01

237

Granuloma anular asociado a linfoma no Hodgkim difuso de células B grandes  

Directory of Open Access Journals (Sweden)

Full Text Available Se presenta el caso de un paciente de 55 años con antecedentes de ser hipertenso controlado, atendido en servicio de hematología por adenopatías de características linfomatosas distribuidas en cadenas ganglionares, axilares, inguinales y epitrocleares distribuidas de forma bilateral. Los exámenes permitieron arribar al diagnóstico de un linfoma no Hogdkin difuso de células B grandes y de un granuloma anular.Granuloma Annulare Associated with non Hodgkin Diffuse Large B-cell LymphomaThe case of a male, 55 years old patient, with a history of controlled hypertension is presented. The patient was treated in the hematology service for adenopathies of lymphomatous type distributed in nodal chains: axillary, inguinal and epitrochlear and bilaterally distributed. Tests allowed to conclude a final diagnose of non Hodgkin diffuse large B-cell lymphoma and a granuloma annulare.  

Liermis M. Dita Salabert

2011-12-01

238

Linfoma T primario colónico: Reporte de un caso y revisión de la literatura  

Scientific Electronic Library Online (English)

Full Text Available SciELO Venezuela | Language: Spanish Abstract in spanish Los linfomas del tracto gastrointestinal son el tipo más frecuente de linfomas extraganglionares y de estos el 15 % a 20 % son de localización intestinal. Los linfomas colónicos primarios son extremadamente raros, comprenden 0,2 % a 0,6 % de todas las neoplasias malignas de colon. Pueden ser B o T. [...] Los tipo T son menos comunes y pueden estar o no asociados a enteropatía celiaca, enfermedad de Crohn y/o SIDA, siendo más frecuente en hombres adultos en una proporción de 2:1. Son de evolución lenta, clínicamente debutan con dolor abdominal asociado a cuadros obstructivos, seguidos de diarrea, hemorragia, perforación, o masa abdominal. El tratamiento es controvertido, en vista de que solamente el 30 % de los pacientes que van a cirugía tienen la firme presunción de linfoma. Presentamos el caso de un paciente masculino de 62 años, quien consultó por dolor abdominal en hipocondrio izquierdo de 30 días de evolución asociado a anorexia, náuseas, vómitos y melena. Los estudios de extensión gastrointestinales reportaron dentro de lo normal, en la tomografía axial computarizada abdominal se evidenció tumoración en hipocondrio izquierdo que comprimía extrínsecamente al colon descendente; siendo intervenido quirúrgicamente hallándose una gran adherencia entre epiplón mayor, peritoneo, mesocolon, ángulo esplénico, yeyuno y mesenterio, en el cual, se evidenció tumoración de 15 cm de diámetro. Se realizó una colectomía parcial y resección intestinal más anastomosis T-T, con buena evolución posoperatoria. Abstract in english Lymphomas of the gastrointestinal tract are the most frequent type of primary extranodal lymphomas and of these, the 15 % to 20 % are of intestinal location. The primary colonic lymphomas is extremely rare, they include 0.2 % to 0.6 % of all the colonic malignant neoplasm. They can be B or T. Intest [...] inal T-cell lymphomas are much less common and can be or no associate to enteropathy celiac, Crohn’s disease and/or AIDS. They are more frequent in adult men in a proportion of 2:1. They are of slow evolution, clinically they make debut with abdominal pain associate to obstructive squares, followed by diarrhea, hemorrhages, perforation or abdominal mass. The treatment is controverted, in view of which only 30 % of the patients who go to surgery have the firm presumption of lymphoma. We present the case of a 62 year-old male patient who consulted by abdominal pain in left hypochondriac of 30 days of evolution associated to anorexia, sick feeling, vomits and manes. The gastrointestinal extension studies reported normal; the Computerized Axial Tomography showed a tumor in left hypochondriac that compressed extrinsically the descending colon. The patient was under surgery finding in a great adherence among great omentun, peritoneum, mesocolon, splenic flexure, jejunum and mesentery surgically, a 15 cm diameter tumor in jejune and great omentun. We realized a partial colectomy and small intestine resection with a T-T anastomosis with a well post-operative evolution.

Gabriela, González Paredes; Estrella C, Uzcátegui Paz; Carlos E, Quintero R.

2006-12-01

239

Contribuição da medicina nuclear para a avaliação dos linfomas Contribution of nuclear medicine in lymphomas approach  

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Full Text Available A medicina nuclear permite a caracterização funcional de tecidos, acrescentando dados à avaliação anatômica realizada por outros métodos de imagem, como a tomografia computadorizada, ressonância magnética ou ultra-som. Além do diagnóstico e estadiamento, as informações funcionais fornecidas pela medicina nuclear são particularmente úteis no seguimento e avaliação de resposta terapêutica dos pacientes com linfoma. A presença de massa residual após quimioterapia ou a infiltração de linfonodos de pequenas dimensões são exemplos de situações nas quais a avaliação isolada de características anatômicas é insuficiente. Os principais métodos utilizados são a cintilografia com gálio-67, traçador com alta afinidade por transferrina e receptores de ferro, e os estudos com flúor-deoxiglicose, emissor de pósitron que permite a caracterização do metabolismo de glicose nos tecidos. Outros traçadores, como o tálio-201, sestamibi-Tc99m e octreotide-In111, também são utilizados em menor escala na avaliação dos pacientes com linfoma. Os mecanismos de captação, principais indicações dos estudos, limitações e resultados de literatura serão revistos.Nuclear medicine procedures allow functional characterization of organs and tissues, that can be compared to the anatomical evaluation provided by computed tomography, magnetic resonance imaging and ultrasonography. Functional information are usefull not only in diagnosis and staging, but mainly in the follow-up and evaluation of the therapeutic response of lymphoma patients. Persistent or residual mediastinal mass and and infiltration of small nodes are some examples of situations in which purely anatomical evaluation is insufficient. The main methods in use are scintigraphy with galium-67, a transferrin avid tracer, and PET with fluoro-desoxyglucose, indicated for the metabolic evaluation of tissues. Other tracers are also described, as thallium-201, 99mTc-sestamibi, and 111In-octreotide. Mechanisms of uptake, indications, limitations and results of the literature are and discussed in this review.

Marcelo T. Sapienza

2001-08-01

240

Contribuição da medicina nuclear para a avaliação dos linfomas / Contribution of nuclear medicine in lymphomas approach  

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Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese A medicina nuclear permite a caracterização funcional de tecidos, acrescentando dados à avaliação anatômica realizada por outros métodos de imagem, como a tomografia computadorizada, ressonância magnética ou ultra-som. Além do diagnóstico e estadiamento, as informações funcionais fornecidas pela med [...] icina nuclear são particularmente úteis no seguimento e avaliação de resposta terapêutica dos pacientes com linfoma. A presença de massa residual após quimioterapia ou a infiltração de linfonodos de pequenas dimensões são exemplos de situações nas quais a avaliação isolada de características anatômicas é insuficiente. Os principais métodos utilizados são a cintilografia com gálio-67, traçador com alta afinidade por transferrina e receptores de ferro, e os estudos com flúor-deoxiglicose, emissor de pósitron que permite a caracterização do metabolismo de glicose nos tecidos. Outros traçadores, como o tálio-201, sestamibi-Tc99m e octreotide-In111, também são utilizados em menor escala na avaliação dos pacientes com linfoma. Os mecanismos de captação, principais indicações dos estudos, limitações e resultados de literatura serão revistos. Abstract in english Nuclear medicine procedures allow functional characterization of organs and tissues, that can be compared to the anatomical evaluation provided by computed tomography, magnetic resonance imaging and ultrasonography. Functional information are usefull not only in diagnosis and staging, but mainly in [...] the follow-up and evaluation of the therapeutic response of lymphoma patients. Persistent or residual mediastinal mass and and infiltration of small nodes are some examples of situations in which purely anatomical evaluation is insufficient. The main methods in use are scintigraphy with galium-67, a transferrin avid tracer, and PET with fluoro-desoxyglucose, indicated for the metabolic evaluation of tissues. Other tracers are also described, as thallium-201, 99mTc-sestamibi, and 111In-octreotide. Mechanisms of uptake, indications, limitations and results of the literature are and discussed in this review.

Marcelo T., Sapienza; Marília M. S., Marone; Carlos S., Chiattone.

2001-08-01

241

Design, construction, and validation of a rotary multifunctional intravascular diagnostic catheter combining multispectral fluorescence lifetime imaging and intravascular ultrasound  

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We report the development and validation of an intravascular rotary catheter for bimodal interrogation of arterial pathologies. This is based on a point-spectroscopy scanning time-resolved fluorescence spectroscopy technique enabling reconstruction of fluorescence lifetime images (FLIm) and providing information on arterial intima composition and intravascular ultrasound (IVUS) providing information on arterial wall morphology. The catheter design allows for independent rotation of the ultrasonic and optical channels within an 8 Fr outer diameter catheter sheath and integrates a low volume flushing channel for blood removal in the optical pathways. In the current configuration, the two channels consist of (a) a standard 3 Fr IVUS catheter with single element transducer (40 MHz) and (b) a side-viewing fiber optic (400 ?m core). Experiments conducted in tissue phantoms showed the ability of the catheter to operate in an intraluminal setting and to generate coregistered FLIm and IVUS in one pull-back scan. Current results demonstrate the feasibility of the catheter for simultaneous bimodal interrogation of arterial lumen and for generation of robust fluorescence lifetime data under IVUS guidance. These results facilitate further development of a FLIm-IVUS technique for intravascular diagnosis of atherosclerotic cardiovascular diseases including vulnerable plaques.

Bec, Julien; Xie, Hongtao; Yankelevich, Diego R.; Zhou, Feifei; Sun, Yang; Ghata, Narugopal; Aldredge, Ralph; Marcu, Laura

2012-10-01

242

Linfoma Linfocítico, bien diferenciado de la próstata: Presentación de un caso y breve revisión de la literatura / Well-differentiated lymphocytic lymphoma of the prostate: Case report and bibliographic review  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish Objetivo: Presentar un caso portador de un linfoma de próstata, en un paciente de 70 años de edad y hacer una breve revisión de la literatura. Método/resultados: Se trata de un paciente varón de 70 años de edad, que es visto en consulta de Urología por presentar un cuadro de prostatismo, llegando a [...] la retención aguda de orina (RAO). Es intervenido quirúrgicamente realizándosele una prostatectomía retropúbica, obteniéndose como resultado anatomopatológico un linfoma primario de próstata, el paciente fue remitido a Oncología, siendo tratado con radioterapia, llevando actualmente seguimiento en consulta de Urología. Se hace una breve revisión bibliográfica, donde analizamos las manifestaciones clínicas de esta entidad, las pruebas complementarias que nos ayudan a hacer el diagnóstico (exámenes de laboratorio, biopsia prostática transrectal, resección transuretral, ecografía, tomografía axial computarizada), los tratamientos que se aplican (cirugía, radioterapia, poliquimioterapia) así como la supervivencia de estos pacientes. Conclusiones: La edad promedio de diagnóstico en la casuística revisada por nosotros fue de 57 años. La forma clínica de debut son síntomas de prostatismo, pudiendo estar presente la RAO y en algunos casos manifestaciones de insuficiencia renal por uropatía obstructiva, así como manifestaciones generales (astenia, anorexia, pérdida de peso). Las cifras de antígeno específico prostático (PSA) no sufren alteraciones en los linfomas prostáticos. El diagnóstico histológico se puede realizar a través de la biopsia de próstata transrectal, aunque puede ser necesario la resección transuretral (RTU) de próstata para una mejor confirmación. La ultrasonografía y la tomografía axial computarizada (TAC) son de gran utilidad para el diagnóstico tanto local como de extensión de estos tumores. Desde el punto de vista del tratamiento puede ser necesario la cirugía desobstructiva (RTU, prostatectomía a cielo abierto), asociación con corticoides y otros citostáticos, la radioterapia y también se ha utilizado la quimioterapia intratecal, el transplante autólogo de médula ósea como complemento. Abstract in english Objective: To report a case of prostate lymphoma and a brief review of the literature. Methods/results: A 70 year-old mele patient was referred to the Urology departament with a clinical picture of prostatism, with acute urinary retention (AUR). Surgery with retropubic prostatectomy was performed, a [...] nd pathology revealed a primary prostate lymphoma. The patient was referred to the departament of Oncology where he received polychemotherapy and radiotherapy. The patient is currently followed by regular visits to Urology outpatients service.The case study is followed by a brief bibliographic review, where we analyse clinical menifestations of this entity, complementary studies useful for diagnosis (laboratory test, trasrectal prostate biopsy, transuretral resection, ultrasound and computerised axial tomography), treatment options (surgery, polychemotherapy, radiotherapy) as well as survival in these patients. Conclusions: Of the cases reviewed, mean age at diagnosis was 57 years. Clinical debut was with prostate symptoms, with or without AUR and sometimes manifestations of renal failure due to obstructive uropathy, as well as general symptoms (astenia, anorexia, weight loss). PSA values remain unaltered in prostate lymphoma patients. Histologic diagnosis may be made by transrectal prostate biopsy, although transurethral resection (TUR) may be necessary for con.rmation. Ultrasound and CT scan are of great utility for diagnosis of both local and distant tumors. From a therapeutic point of view, surgery for the obstruction of the lower urinary tract (TURP or retropubic prostatectomy) may be necessary, as well as the cyclophosphamide based polychemotherapy with corticosteroids and other cytostatic agents, and radiotherapy; intratecal chemotherapy has also been used adjuvant bon

Otto, Ochoa Undargarain; José A., Hermida Pérez; Johannes, Ochoa Montes de Oca; Juan M., Félix León.

2006-06-01

243

Diagnóstico y tratamiento de pacientes con linfomas primarios del sistema nervioso central (LPSN) y sindrome de inmunodeficiencia adquirida (SIDA) / Diagnostic and treatment of patients with primary lymphomas of the central nervous system and required inmunodeficiency syndrome  

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Full Text Available SciELO Peru | Language: Spanish Abstract in spanish La incidencia del linfoma primario del sistema nervioso central (LPSNC) ha crecido rápidamente. El LPSNC as una complicación letal en pacientes con SIDA. Objetivo: Nuestro objetivo fue estudiar la historia natural, métodos diagnósticos, al tratamiento y los factores pronósticos para la sobrevida de [...] 75 pacientes con LPSNC y SIDA seguidos en el Jackson Memorial Hospital/Universidad de Miami. Resultados: La edad media fue de 37 años. El 84% de los pacientes eran hombres y el 55% hispanos. Factores de riesgo más comunes para SIDA fueron homosexualidad y múltiples compañeros sexuales. La cuenta promedio de CD4 fue de 15/ul y al promedio de LDH fue 1.5 veces al normal. La tomografía computarizada del cerebro mostraba lesiones múltiples en el 44% de los pacientes. Gammagrafia computarizada de emisión de fotones con talio-201 (SPECT) del cerebro se realizó en 2/3 de los pacientes. Las histologías más comunes en las biopsias fueron: linfoma inmunoblástico y linfoma de células grandes. La radiación craneana fue ineficiente en el 50% de los pacientes tratados. La sobrevida promedio del grupo fue de 2.2 meses. Análisis univariado y multivariado mostraron que la mayor sobrevida se asociaba con una buena capacidad funcional (ECOG=1-2 vs 3-4). La presencia previa de infecciones oportunistas, la presencia de factores de riesgo de SIDA, las cuentas de CD4, niveles de LDH y raza no mostraron influencia en la sobrevida. Conclusiones: LPSNC es una neoplasia con pronóstico muy pobre y corta sobrevida aun con radioterapia del SNC. La capacidad funcional parece ser al factor de sobrevida más importante. No se encontraron diferencias en la presentación clínica ni el resultado entre pacientes hispanos y no hispanos. ( Rev Med Hered 1999; 10:96-104 ). Abstract in english The incidence of Primary Central Nervous System Lymphoma (PCNSL) is increasing rapidly. PCNSL is an important lethal complication in AIDS patients. Objective: Our objective was to study the natural history and prognostic factors for survival in patients with AIDS related PCNSL. Material and methods: [...] This is a retrospective cohort study of 75 patients with the diagnosis of AIDS related PCNSL followed at Jackson Memorial Hospital University of Miami. Results: The median age was 37 years. Males comprised 84% of the patients and 55% of the patients were Hispanic. The most common HIV risk factors were homosexuality and multiple sexual partners. The median CD4 count was 15/~L and the median LDH were 1.5x normal. CT Scans of the brain showed multiple lesions in 44% of the patients. Single-Photon Emission CT Scan (SPECT) Thallium-201 of the brain was performed in 2/3 of patients. The most common histologies were immunoblastic and large cell lymphoma. Cranial radiation was given to 72% of the patients and 55% of them did not completed. The median survival of the group was 1.3 months. Univariate and multivariate analysis showed that longer survival was associated with good performance status (ECOG=1-2 Vs 3-4). The presence of prior opportunistic infections, risk factors for AIDS, CD4 counts, level of LDH, ethnicity, gender, duration of symptoms before diagnosis, and race did not influence survival. Conclusions: PCNSL is a neoplasm with a very poor prognosis and short survival even with CNS radiation therapy. Performance status appears to be the main prognostic factor for survival. No significant differences in presentation or outcome were detected between the Hispanic and non-Hispanic patients. ( Rev Med Hered 1999; 10: 96-104 ).

Luis E, Raez; Juanita, Angulo; Alvaro, Restrepo.

1999-07-01

244

Primary liver AIDS-related lympoma / Linfoma não-Hodgkin primário do fígado em paciente com SIDA  

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Full Text Available Os linfomas não-Hodgkin (LNH) são as segundas neoplasias mais freqüentes nos pacientes com síndrome da imunodeficiência adquirida (SIDA). A maioria dos LNH associados à AIDS envolvem locais extra-ganglionares, especialmente o trato digestivo e o sistema nervoso central. O linfoma não-Hodgkin primári [...] o do fígado (LPF) é uma neoplasia incomum nestes pacientes. A ultrassonografia (US) e a tomografia computadorizada (TC) podem ser úteis no diagnóstico de linfoma não-Hodgkin hepático apresentando-se como lesões multifocais. A biópsia com agulha fina guiada por imagens (US, TC) juntamente com a histopatologia das lesões do fígado constitui o padrão-ouro para o diagnóstico de linfoma hepático. Este trabalho relata um caso de LPF como manifestação inicial de AIDS em um paciente sem infecção prévia pelo vírus da hepatite C e B, que se apresentou como massas hepáticas múltiplas e de grandes dimensões. Abstract in english Non-Hodgkin's lymphomas (NHL) are the second most frequent malignancies in AIDS patients. The majority of NHL associated with AIDS involves extranodal sites, especially the digestive tract and the central nervous system. Primary liver lymphoma (PLL) is an uncommon neoplasm among these patients. Ultr [...] asonography and computed tomography scans may be helpful in the diagnosis of focal hepatic lymphoma. Image-guided fine-needle biopsy with histopathology of the liver lesions is the gold standard for the diagnosis of hepatic lymphoma. We report a case of PLL as the initial manifestation of AIDS in a patient without any previous infection by hepatitis C or B virus, presented as multiple and large hepatic masses.

María Florencia, Villafañe; Norberto, Trione; Marcelo, Corti; Nora, Mendez; Elisa, Gancedo; Norberto, Zamora; Marta, Levin.

2006-08-01

245

Non Hodgkin T cell lymphoma: an atypical clinical presentation Linfoma não Hodgkin de células T citotóxico: uma apresentação clínica atípica  

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Full Text Available Cytotoxic lymphomas comprise a spectrum of peripheral T-cell lymphomas that can have a initial or late cutaneous presentation. We describe a 46-year-old man from Cape Verde, with a dermatosis involving his face and trunk, consisting of monomorphic papules with a smooth surface and both motor and sensory polyneuropathy.The hypothesis of leprosy was supported by the clinical and initial hystopathological findings and the patient was referred to our hospital with suspected Hansen's disease. In the new skin and lymph node biopsies a lymphocyte population was identified whose immunohystochemistry study allowed the diagnosis of T-cell lymphoma with expression of cytotoxic markers. The patient was started on chemotherapy with initial remission of the skin lesions but, subsequently, progression of systemic disease.Os linfomas citotóxicos compreendem um espectro de linfomas de células T periféricos e linfomas Natural Killer que podem ter expressão cutânea primária ou secundária. Descrevemos o caso de um homem com 46 anos de idade, natural de Cabo Verde,com dermatose envolvendo a face e tronco constituída por pápulas monomorfas superfície lisa e polineuropatia sensitivo motora.A hipótese de Hanseníase foi colocada suportada por achados histopatológicos sugestivos sendo o doente referenciado à consulta de Doença de Hansen do nosso hospital. Em biopsia de pele e de gânglio identificou-se proliferação linfocitária cujo estudo imunohistoquímico permitiu o diagnóstico de linfoma T com expressão de marcadores citotóxicos. Iniciou quimioterapia verificando-se inicialmente remissão parcial das lesões cutâneas mas posteriormente a progressão da doença sistémica.

Paula Maio

2013-04-01

246

Primary liver AIDS-related lympoma Linfoma não-Hodgkin primário do fígado em paciente com SIDA  

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Full Text Available Non-Hodgkin's lymphomas (NHL are the second most frequent malignancies in AIDS patients. The majority of NHL associated with AIDS involves extranodal sites, especially the digestive tract and the central nervous system. Primary liver lymphoma (PLL is an uncommon neoplasm among these patients. Ultrasonography and computed tomography scans may be helpful in the diagnosis of focal hepatic lymphoma. Image-guided fine-needle biopsy with histopathology of the liver lesions is the gold standard for the diagnosis of hepatic lymphoma. We report a case of PLL as the initial manifestation of AIDS in a patient without any previous infection by hepatitis C or B virus, presented as multiple and large hepatic masses.Os linfomas não-Hodgkin (LNH são as segundas neoplasias mais freqüentes nos pacientes com síndrome da imunodeficiência adquirida (SIDA. A maioria dos LNH associados à AIDS envolvem locais extra-ganglionares, especialmente o trato digestivo e o sistema nervoso central. O linfoma não-Hodgkin primário do fígado (LPF é uma neoplasia incomum nestes pacientes. A ultrassonografia (US e a tomografia computadorizada (TC podem ser úteis no diagnóstico de linfoma não-Hodgkin hepático apresentando-se como lesões multifocais. A biópsia com agulha fina guiada por imagens (US, TC juntamente com a histopatologia das lesões do fígado constitui o padrão-ouro para o diagnóstico de linfoma hepático. Este trabalho relata um caso de LPF como manifestação inicial de AIDS em um paciente sem infecção prévia pelo vírus da hepatite C e B, que se apresentou como massas hepáticas múltiplas e de grandes dimensões.

María Florencia Villafañe

2006-08-01

247

Non Hodgkin T cell lymphoma: an atypical clinical presentation / Linfoma não Hodgkin de células T citotóxico: uma apresentação clínica atípica  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese Os linfomas citotóxicos compreendem um espectro de linfomas de células T periféricos e linfomas Natural Killer que podem ter expressão cutânea primária ou secundária. Descrevemos o caso de um homem com 46 anos de idade, natural de Cabo Verde,com dermatose envolvendo a face e tronco constituída por p [...] ápulas monomorfas superfície lisa e polineuropatia sensitivo motora.A hipótese de Hanseníase foi colocada suportada por achados histopatológicos sugestivos sendo o doente referenciado à consulta de Doença de Hansen do nosso hospital. Em biopsia de pele e de gânglio identificou-se proliferação linfocitária cujo estudo imunohistoquímico permitiu o diagnóstico de linfoma T com expressão de marcadores citotóxicos. Iniciou quimioterapia verificando-se inicialmente remissão parcial das lesões cutâneas mas posteriormente a progressão da doença sistémica. Abstract in english Cytotoxic lymphomas comprise a spectrum of peripheral T-cell lymphomas that can have a initial or late cutaneous presentation. We describe a 46-year-old man from Cape Verde, with a dermatosis involving his face and trunk, consisting of monomorphic papules with a smooth surface and both motor and sen [...] sory polyneuropathy.The hypothesis of leprosy was supported by the clinical and initial hystopathological findings and the patient was referred to our hospital with suspected Hansen's disease. In the new skin and lymph node biopsies a lymphocyte population was identified whose immunohystochemistry study allowed the diagnosis of T-cell lymphoma with expression of cytotoxic markers. The patient was started on chemotherapy with initial remission of the skin lesions but, subsequently, progression of systemic disease.

Paula, Maio; Diogo, Bento; Raquel, Vieira; Ana, Afonso; Fernanda, Sachse; Heinz, Kutzner.

2013-04-01

248

ENFERMEDAD RENAL POLIQUISTICA ASOCIADA A LINFOMA EXTRANODAL EN UN CANINO / RENAL POLICYST DISEASE ASSOCIATED TO LYMPHOMA EXTRANODAL IN A CANINE  

Scientific Electronic Library Online (English)

Full Text Available SciELO Colombia | Language: Spanish Abstract in spanish Objetivo: Presentar el caso de un paciente canino, con enfermedad renal poliquística, asociada a linfoma extranodal. Materiales y métodos: Se estudió el caso de un paciente canino de raza Siberian Husky de 7 años de edad, al que se le encontraron múltiples nódulos renales bilaterales, con diagnóstic [...] o histopatológico de linfoma extranodal. Resultados: Se expone el caso clínico de un paciente canino de raza Siberian Husky, que es presentado a consulta dermatológica por exhibir lesiones alopécicas multifocales. Una vez realizado el examen físico sistemático se evidenció de manera incidental nefromegalia. Los exámenes paraclínicos e histopatológicos aplicados demostraron la presencia de enfermedad renal poliquística asociada a linfoma extranodal, como consecuencia se presento falla renal crónica. Conclusiones: El linfoma extranodal renal es una entidad patológica de rara presentación, clínicamente cursa con signos muy similares a otras alteraciones tumorales, su diagnóstico suele ser histopatológico. Abstract in english Objective: To present the case of a canine patient, with renal policyst disease, associated to extranodal lymphoma. Materials and methods: The case of a canine patient Siberian Husky, of 7 years old was studied to which multiple bilateral renal nodules were found, with histopathological diagnostic o [...] f extranodal lymphoma. Results: The clinical case of a canine patient of race Siberian Husky is exposed and presented to dermatological consultation to exhibit alopecia multifocal lesions. Once made the systematic physical exam was evidenced nephromegaly in incidental way. The paraclinical and applied histopathological exams demonstrated the presence of renal policyst disease associated to extranodal lymphoma, as consequence renal chronicle alteration was presented. Conclusions: The renal extranodal lymphoma is a pathological entity of strange presentation, clinically frequent with very similar signs to other tumoral alterations, its diagnosis is usually histopathological.

Diego, Echeverry B; Ximena, Barbosa S; Edwin, Buriticá G.

2006-07-01

249

Recurrence of peripheral T-cell lymphoma as granulomas in the lower limbs / Granulomas epitelióides cutâneos, como manifestação de recidiva de linfoma de células T periférico  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese A presença de granulomas cutâneos associados a linfomas é um fenômeno raro, mas bem conhecido. Um homem, 44 anos de idade, com diagnóstico prévio de linfoma de células T periférico, foi enviado à nossa consulta por infiltração cutânea e extensa discromia nos membros inferiores. A biopsia cutânea rev [...] elou a presença de granulomas epitelioides associados à recidiva do linfoma, confirmada pela marcação imuno-histoquímica e estudo molecular. Apesar de iniciado novo esquema de quimioterapia, o doente faleceu 18 meses depois. Na literatura são descritos dois tipos de granulomas cutâneos na presença de linfomas: associados à infiltração cutânea pelo linfoma ou como uma manifestação não específica do linfoma. Contudo, atualmente não há evidência que suporte a sua relação com o prognóstico dos linfomas. Abstract in english The presence of granulomas in the skin of T-cell lymphoma patients is a rare but well-known phenomenon. The authors present the case of a 44-year-old Caucasian male, with a previously treated peripheral T-cell lymphoma, with cutaneous infiltration and extensive dyschromia on his lower limbs. Skin bi [...] opsies revealed the presence of sarcoid granulomas associated with the recurrence of the lymphoma, confirmed by immunostaining and molecular analysis. Although a new scheme of chemotherapy was started, he died 18 months later. There are two different patterns of skin granulomas associated with lymphoma: granulomatous infiltrates admixed with neoplastic cells and cutaneous granulomas constituting a nonspecific manifestation of the underlying lymphoma, but presently there is no evidence supporting their relationship with lymphoma prognosis.

Ana Rita, Travassos; João, Borges-Costa; João, Raposo; Luís Soares, Almeida; Paulo, Filipe.

2012-10-01

250

Significado prognóstico dos graus histológicos do linfoma de Hodgkin do tipo esclerose nodular / Prognostic significance of histopathological grading of nodular sclerosing Hodgkin’s lymphoma  

Scientific Electronic Library Online (English)

Full Text Available INTRODUÇÃO: A esclerose nodular (EN), do tipo histológico freqüente do linfoma de Hodgkin (LH), apresenta grande variabilidade em sua composição celular. Na década de 80, pesquisadores do British National Lymphoma Investigation (BNLI) propuseram uma subclassificação histológica do LH EN. Eles identi [...] ficaram dois graus histológicos - o LH EN grau I (LH EN I) e o LH EN grau II (LH EN II) - e demonstraram que os portadores de LH EN II apresentavam menor sobrevida em comparação aos portadores de LH EN I. Outros estudos, entretanto, não reproduziram esses achados. OBJETIVO: Avaliar o significado prognóstico da graduação histológica proposta pelo BNLI. MATERIAIS E MÉTODOS: Estudo retrospectivo que incluiu 69 casos de LH EN. Mais de 90% dos casos foram tratados com terapia combinada ou quimioterapia exclusiva, não havendo diferença no tipo de tratamento oferecido a depender do grau histológico. RESULTADOS: Trinta e cinco casos (51%) foram classificados com EN I e 34 (49%) como EN II. Não observamos diferenças na distribuição de outros fatores prognósticos entre os portadores dos dois graus. Remissão completa após o tratamento inicial foi obtida em 85,7% dos casos de EN I e em 82,4% dos casos de EN II (p = 0,75). A probabilidade estimada de sobrevida global em cinco anos foi de 67% para EN I e de 83,5% para EN II (p = 0,13) e a taxa de sobrevida livre de doença em cinco anos foi de 85,2% versus 87%, respectivamente (p = 0,72). CONCLUSÃO: Nesta população de pacientes uniformemente tratados a graduação histológica BNLI não esteve associada com o prognóstico do LH EN. Abstract in english BACKGROUND: Nodular sclerosis (NS), a frequent histological subtype of Hodgkin’s lymphoma (HL), presents great variability in its cellular composition. In the 80's, researchers of the British National Lymphoma Investigation (BNLI) proposed a histological-based subclassification for NS HL. They ident [...] ified two histological grades - NS HL grade I (NS HL I) and NS HL grade II (NS HL II) - and reported that NS II patients had a lower survival rate in comparison with NS I patients. Others studies, however, did not reproduce these findings. OBJECTIVE: Evaluate the prognostic significance of the BNLI grading system. MATERIAL AND METHOD: We retrospectively studied 69 NS HL patients. More than 90% of the included cases were treated with combined modality therapy or exclusive chemotherapy, the treatment type was not different for NS I and NS II patients. RESULTS: Thirty-five cases (51%) were classified as NS I and 34 (49%) as NS II. We did not observe significant differences in the distribution of other prognostic factors between the two NS grades. The complete remission rate after initial therapy was 85.7% in the NS I group and 82.4% in the NS II group (p = 0.75). The predicted 5-year overall survival rate was 67% in the NS I patients and 83.5% in the NS II patients (p = 0.13). The predicted 5-year disease free survival rate for NSI and NSII patients was 85.2% and 87%, respectively (p = 0.72). CONCLUSION: The histological BNLI grading system was not associated with the prognosis of this uniformly treated NS LH population.

Luís Fernando, Pracchia; Valeria, Buccheri; Yara de, Menezes; Sheila A. C., Siqueira; Nair Sumie, Mori; Dalton Alencar Fisher, Chamone.

2005-10-01

251

Significado prognóstico dos graus histológicos do linfoma de Hodgkin do tipo esclerose nodular Prognostic significance of histopathological grading of nodular sclerosing Hodgkin’s lymphoma  

Directory of Open Access Journals (Sweden)

Full Text Available INTRODUÇÃO: A esclerose nodular (EN, do tipo histológico freqüente do linfoma de Hodgkin (LH, apresenta grande variabilidade em sua composição celular. Na década de 80, pesquisadores do British National Lymphoma Investigation (BNLI propuseram uma subclassificação histológica do LH EN. Eles identificaram dois graus histológicos - o LH EN grau I (LH EN I e o LH EN grau II (LH EN II - e demonstraram que os portadores de LH EN II apresentavam menor sobrevida em comparação aos portadores de LH EN I. Outros estudos, entretanto, não reproduziram esses achados. OBJETIVO: Avaliar o significado prognóstico da graduação histológica proposta pelo BNLI. MATERIAIS E MÉTODOS: Estudo retrospectivo que incluiu 69 casos de LH EN. Mais de 90% dos casos foram tratados com terapia combinada ou quimioterapia exclusiva, não havendo diferença no tipo de tratamento oferecido a depender do grau histológico. RESULTADOS: Trinta e cinco casos (51% foram classificados com EN I e 34 (49% como EN II. Não observamos diferenças na distribuição de outros fatores prognósticos entre os portadores dos dois graus. Remissão completa após o tratamento inicial foi obtida em 85,7% dos casos de EN I e em 82,4% dos casos de EN II (p = 0,75. A probabilidade estimada de sobrevida global em cinco anos foi de 67% para EN I e de 83,5% para EN II (p = 0,13 e a taxa de sobrevida livre de doença em cinco anos foi de 85,2% versus 87%, respectivamente (p = 0,72. CONCLUSÃO: Nesta população de pacientes uniformemente tratados a graduação histológica BNLI não esteve associada com o prognóstico do LH EN.BACKGROUND: Nodular sclerosis (NS, a frequent histological subtype of Hodgkin’s lymphoma (HL, presents great variability in its cellular composition. In the 80's, researchers of the British National Lymphoma Investigation (BNLI proposed a histological-based subclassification for NS HL. They identified two histological grades - NS HL grade I (NS HL I and NS HL grade II (NS HL II - and reported that NS II patients had a lower survival rate in comparison with NS I patients. Others studies, however, did not reproduce these findings. OBJECTIVE: Evaluate the prognostic significance of the BNLI grading system. MATERIAL AND METHOD: We retrospectively studied 69 NS HL patients. More than 90% of the included cases were treated with combined modality therapy or exclusive chemotherapy, the treatment type was not different for NS I and NS II patients. RESULTS: Thirty-five cases (51% were classified as NS I and 34 (49% as NS II. We did not observe significant differences in the distribution of other prognostic factors between the two NS grades. The complete remission rate after initial therapy was 85.7% in the NS I group and 82.4% in the NS II group (p = 0.75. The predicted 5-year overall survival rate was 67% in the NS I patients and 83.5% in the NS II patients (p = 0.13. The predicted 5-year disease free survival rate for NSI and NSII patients was 85.2% and 87%, respectively (p = 0.72. CONCLUSION: The histological BNLI grading system was not associated with the prognosis of this uniformly treated NS LH population.

Luís Fernando Pracchia

2005-10-01

252

Intravascular Papillary Endothelial Hyperplasia(Masson's Tumor) of the Chest Wall: A Case Report  

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Intravascular papillary endothelial hyperplasia is a rare tumor-like lesion caused by hyperplastic proliferation of endothlial cells that is usually an incidental findings within thrombosed dilated blood vessels or vascular tumor. We report the sonographic appearance and pathological correlation of intravascular papillary endothelial hyperplasia that presented as an intramuscular solitary mass in chest wall

Kim, Ga Ram [Severance Hospital, Yonsei University College of Medicine, Seoul (Korea, Republic of); Joo, Seung Ho; Kie, Jeong Hae; Hong, Ki Pyo; Shim, Joo Eun [NHIC Ilsan Hospital, Ilsan (Korea, Republic of)

2009-12-15

253

LINFOMA CUTÁNEO DE CÉLULAS B TIPO CENTRO FOLICULAR CON INFILTRACIÓN A MÉDULA ÓSEA: REPORTE DE UN CASO / PRIMARY CUTANEOUS FOLLICLE CENTER LYMPHOMA WITH BONE MARROW INFILTRATION: RELATÓRIO DE UM CASO / LINFOMA CUTÂNEO DE CÉLULAS B TIPO CENTRO FOLICULAR COM INFILTRAÇÃO NA MEDULA ÓSSEA  

Scientific Electronic Library Online (English)

Full Text Available Os linfomas cutâneos primários de células B constituem cerca de 20 a 25% de todos os linfomas. O linfoma cutâneo primário de células B tipo centro folicular é o subtipo mais frequente e manifestase principalmente em pacientes adultos com uma idade média de 58 anos (1), a disseminação extracutânea é [...] muito rara e apresentase com nódulos, tumores ou placas solitárias no grupo usualmente localizados na cabeça ou tronco. Apresentamos o caso de uma paciente com um linfoma primário cutâneo tipo centro folicular com infiltração na medula óssea. Abstract in spanish Los linfomas cutáneos primarios de células B constituyen cerca del 2025% de todos los linfomas. El linfoma cutáneo primario de células B tipo centro folicular es el subtipo más frecuente y se manifiesta principalmente en pacientes adultos con una edad media de 58 años (1), la diseminación extracután [...] ea es muy rara y se presenta con nódulos, tumores o placas solitarios o en grupo usualmente localizados en cabeza o tronco. Presentamos el caso de una paciente con un linfoma primario cutáneo tipo centro folicular con infiltración a médula ósea. Abstract in english Primary B cell cutaneous lymphomas represent approximately 2025% of all lymphomas. Primary cutaneous follicle center lymphoma is the most common subtype occurring in adults with a mean age of 58 years. The disease typically presents with solitary plaques or nodules and is usually located in the head [...] or trunk. Extra cutaneous dissemination is extremely rare. We present a case of a patient with primary cutaneous follicle center lymphoma with bone marrow infiltration.

CLAUDIA MARCELA, ARENAS SOTO; MARÍA LILIANA, MARIÑO ÁLVAREZ; JORGE ENRIQUE, CALDERÓN GÓMEZ; MARÍA ISABEL, GONZÁLEZ C; MARTHA PATRICIA, ROBAYO.

2012-06-01

254

Linfoma cutáneo angiocéntrico de células T que semeja hidroa vacciniforme / Angiocentric cutaneous lymphoma in a 14 year old female adolescent  

Scientific Electronic Library Online (English)

Full Text Available Introducción. Los linfomas cutáneos son procesos linfoproliferativos malignos de células B o T, con una variedad de manifestaciones clínicas, sin que exista enfermedad extracutánea al momento del diagnóstico. Existen reportes de casos de lesiones cutáneas previas, determinadas por fotosensibilidad, [...] que se asocian a linfomas cutáneos. Se presenta el caso de un paciente femenino con diagnóstico de linfoma cutáneo angiocéntrico que semeja hidroa vacciniforme. Caso clínico. Adolescente femenino de 14 años de edad, que ingresó al Hospital General Dr. Aurelio Valdivieso del Estado de Oaxaca en el mes de octubre de 2003. Cuadro actual: 8 meses previos a su ingreso con dermatosis en áreas expuestas al sol, caracterizadas por vesículas y pápulas, que evolucionaron a úlceras y necrosis en miembros torácicos y piernas, con hepatoesplenomegalia y edema centrofacial. La histopatología de la lesión reveló vasculitis angiocéntrica, angiodestructiva, con linfocitos atípicos y paniculitis. Se definió el diagnóstico de linfoma cutáneo angiocéntrico. Se instaló quimioterapia combinada con involución de su dermatosis y compromiso sistémico. Conclusión. El presente caso cumple con criterios clínico e histopatológicos de linfoma cutáneo angiocéntrico, con adecuada respuesta a quimioterapia de combinación, sobre todo basada en antraciclinas. Abstract in english Introduction. The cutaneous lymphoma is a malignant lymphoproliferative process of B or T, cells with a variety of clinical manifestation without extracutaneous disease at the time of diagnosis. There are case reports in the literature which have associated prior cutaneous injuries, with cutaneous l [...] ymphoma as determined by photosensitization. The present case report is of a female patient with diagnosis of cutaneous angiocentric lymphoma which resembled hydroa vacciniform. Case report. Female adolescent 14 year of age who was admitted to Hospital General Dr. Aurelio Valdivieso in the State of Oaxaca, Mexico. Eight months prior to hospital admission she presented dermatosis in areas exposed to the sun, characterized by vesicles, papules which evolved to ulcers and necrosis in arms and legs, she also presented with hepatosplenomegaly and facial edema. The histopatology of the lesions revealed angiodestructive, angiocentric vasculitis with atypical lymphocytes and paniculitis. The diagnosis of angiocentric cutaneous lymphoma was made. The patient was treated with combined chemotherapy with involution of her dermatosis and systemic findings. Conclusion. The present case fulfills the histopathology and clinical criteria of an angiocentric cutaneous lymphoma, with suitable response to combined chemotherapy based on anthracyclines.

Armando, Quero-Hernández; Luis M., Sánchez-Navarro; Zoila, Socorro-López; Daniel, Carrasco-Daza.

2005-02-01

255

Laser-activated shape memory polymer intravascular thrombectomy device  

Science.gov (United States)

A blood clot (thrombus) that becomes lodged in the arterial network supplying the brain can cause an ischemic stroke, depriving the brain of oxygen and often resulting in permanent disability. As an alternative to conventional clot-dissolving drug treatment, we are developing an intravascular laser-activated therapeutic device using shape memory polymer (SMP) to mechanically retrieve the thrombus and restore blood flow to the brain. Thermal imaging and computer simulation were used to characterize the optical and photothermal behavior of the SMP microactuator. Deployment of the SMP device in an in vitro thrombotic vascular occlusion model demonstrated the clinical treatment concept.

Small, Ward, IV; Wilson, Thomas S.; Benett, William J.; Loge, Jeffrey M.; Maitland, Duncan J.

2005-10-01

256

Histamine release and endothelial leakage from an intravascular contrast medium  

International Nuclear Information System (INIS)

The endothelial injury produced by meglumine iodamide was studied in the rat aorta. A mixture of blood and contrast medium was more toxic to the endothelium than the pure contrast agent. This difference disappeared after premedication with antihistamine, which did not affect the injury produced by the pure contrast agent. Meglumine iodamide appears to cause a release of histamine from blood but not from the aortic endothelium nor from surrounding tissues in amounts demonstrable by this method. Leucocytes are a source of histamine after intravascular contrast medium administration. (orig.)

257

Disseminated Intravascular Coagulation with Acutely-Thrombosed Popliteal Aneurysm  

Science.gov (United States)

Disseminated intravascular coagulation (DIC) is an extremely rare complication of acute thrombosis in popliteal aneurysms and makes it difficult to restore the blood flow with thrombolytic therapy or surgical repair. A 75-year-old man with a history of hypertension presented to the emergency department with complaints of right leg pain and bleeding tendency over a 5-day period. The laboratory findings and multislice computed tomography were suggestive of overt DIC caused by acute thrombosis in the right popliteal aneurysm. Successfully treated with medication, he could discharge without surgical or thrombolytic recanalization of the aneurysm. PMID:23555403

2010-01-01

258

Primary Intrarenal Neuroblastoma with Hypertension and Disseminated Intravascular Coagulation  

Science.gov (United States)

The primary intrarenal neuroblastoma (IRNB) is a rare condition. Intrarenal neuroblastoma typically results from direct renal invasion from an adrenal neuroblastoma, but true intrarenal neuroblastoma originates either sequestered adrenal rests during the fetal life or intrarenal sympathetic ganglia. Clinical, radiological, and pathological correlation is very essential for diagnosis and appropriate management of this type of unusual cases. The distinction of this rare tumor from Wilms' tumor is an important challenge since both tumors have major differences in prognostic and therapeutic response. We present a 3-year-old boy of primary intrarenal neuroblastoma with extensive abdominal and mediastinal mass, persistent hypertension, and disseminated intravascular coagulation (DIC). PMID:24416605

Shamsian, Bibi Shahin; Kajizadi, Mohammad; Ghojehvand, Nozar; Azma, Roxana; Rouzrokh, Mohsen; Kazemi Aghdam, Maryam; Mesbah, Seyed Malek; Ghazizadeh, Farid; Arzanian, Mohammad Taghi

2013-01-01

259

Venous gas embolism - Time course of residual pulmonary intravascular bubbles  

Science.gov (United States)

A study was carried out to determine the time course of residual pulmonary intravascular bubbles after embolization with known amounts of venous air, using an N2O challenge technique. Attention was also given to the length of time that the venous gas emboli remained as discrete bubbles in the lungs with 100 percent oxygen ventilation. The data indicate that venous gas emboli can remain in the pulmonary vasculature as discrete bubbles for periods lasting up to 43 + or - 10.8 min in dogs ventilated with oxygen and nitrogen. With 100 percent oxygen ventilation, these values are reduced significantly to 19 + or - 2.5 min.

Butler, B. D.; Luehr, S.; Katz, J.

1989-01-01

260

Intravascular foreign bodies: what the radiologist needs to know.  

Science.gov (United States)

The intravascular foreign bodies (IFBs) can originate from many sources both iatrogenic and noniatrogenic; as the frequency of endovascular therapies increases, the incidence of lost or embolized iatrogenic foreign bodies is also increasing. As IFB can cause significant complications such as thrombosis, pulmonary and peripheral embolism, etc. It is therefore necessary to remove them, and this may be accomplished through surgery or by means of percutaneous radiologic techniques. Percutaneous approach is widely perceived as the best way to retrieve IFB. We provide an overview of recent literature, clarifying what devices are being lost, what symptoms occur as a result, and how retrieval is being performed. PMID:25639180

Floridi, Chiara; Nocchi-Cardim, Larissa; De Chiara, Marco; Ierardi, Anna Maria; Carrafiello, Gianpaolo

2015-02-01

261

Changes in fetal acid base status during intravascular transfusion.  

OpenAIRE

Umbilical venous pH, PCO2, PO2, and base excess was measured immediately before and after 72 intravascular transfusions in 34 fetuses with erythroblastosis fetalis. In 67 uncomplicated transfusions, infused adult blood led to a mean (95% confidence intervals) fall in pH (0.037, CI 0.029 to 0.044) and base excess (2.03, CI 1.61 to 2.45) and a mean rise in PCO2 (0.24 kPa, CI 0.13 to 0.35). These changes correlated significantly with the increase in fetal haemoglobin and packed cell volume. Five...

Nicolini, U.; Santolaya, J.; Fisk, N. M.; Hubinont, C.; Kochenour, N. K.; Greco, P.; Rodeck, C. H.

1988-01-01

262

Rituximab monotherapy for splenic marginal zone lymphoma with villous lymphocytes: report on long-term disease control for two patients with recurrence after splenectomy / Monoterapia com rituximab no linfoma da zona marginal esplênico com linfócitos vilosos: relato de dois casos de pacientes com controle prolongado da doença depois de recidiva após esplenectomia  

Scientific Electronic Library Online (English)

Full Text Available CONTEXTO: Os linfomas da zona marginal esplênicos constituem uma desordem linfoproliferativa de células B que apresenta um prognóstico favorável, com sobrevida global de cinco anos estimada em 70%. A maioria dos pacientes sintomáticos é submetida a esplenectomia enquanto alguns recebem quimioterapia [...] terapêutica de primeira linha, especialmente com análogos de purinas. Não existem diretrizes específicas para o tratamento dos pacientes que falham à esplenectomia: ainda é incerto se deveriam ser tratados com quimioterapia citotóxica, em virtude de apresentarem um linfoma recidivado (e teoricamente mais agressivo) ou se deveriam ser poupados de um tratamento mais tóxico pelo fato de apresentarem uma doença que usualmente se desenvolve de forma mais indolente, mesmo quando recidivada. RELATO DE CASO: Nesta publicação, são apresentados dois casos nos quais a doença recidivou após esplenectomia e que foram satisfatoriamente tratados com monoterapia com rituximabe. A observação desses casos sugere que a postergação de tratamentos citotóxicos pode ser possível pelo menos em algumas situações. Cabe ressaltar que a evidência para essa conduta é embasada apenas em relatos de caso, uma vez que não existem ensaios clínicos randomizados a respeito desse tema. Abstract in english CONTEXT: Splenic marginal zone lymphoma (SMZL) is a lymphoproliferative B-cell disorder that has a favorable prognosis, with estimated overall five-year survival of 70%. The majority of symptomatic patients undergo splenectomy, while a few receive first-line chemotherapy, especially with purine anal [...] ogues. There are no specific treatment guidelines for patients for whom splenectomy fails to provide a cure. It is still unclear whether these patients should undergo cytotoxic chemotherapy, considering they have now a relapsed lymphoma (which is theoretically more aggressive), or whether they should be spared from treatments of greater toxicity, given that their disease usually develops with a more indolent course, even when it recurs. CASE REPORT: Here, we present two patients whose disease recurred after splenectomy and for whom rituximab monotherapy provided satisfactory treatment. From these cases, it can be suggested that postponement of cytotoxic treatments may be possible in at least some situations. It needs to be emphasized that the evidence to support this approach is based only on case reports, since there are no randomized clinical trials on this subject.

Márcio, Debiasi; Marluce, Hehnemann; Bernardo, Garicochea.

2010-12-01

263

Linfoma no Hodgkin de células del manto con infiltración renal y glomerulopatía mesangiocapilar asociada / Mantle cell non-Hodgkin lymphoma with renal infiltration and associated mesangiocapillary glomerulopathy  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish El linfoma de células del manto es una forma infrecuente de linfoma no Hodgkin con alta frecuencia de recaídas y peor pronóstico. Los linfomas pueden inducir daño renal de diferentes modos, entre los que se encuentran la infiltración renal y el desarrollo de glomerulopatías. Se presentó un caso en e [...] l que se asocia el comienzo clínico de un linfoma de células del manto con infiltración parenquimatosa renal y glomerulonefritis mesangiocapilar sin crioglobulinemia. Este constituye el primer caso reportado con esta asociación y pone en evidencia las diferentes formas de afectación renal del linfoma no Hodgkin y el valor del estudio histológico renal, para el diagnóstico y el pronóstico de las enfermedades oncohematológicas con daño renal. Abstract in english Mantle cell lymphoma is an infrequent type of non-Hodgkin lymphoma with high relapse rates and poor prognosis. Lymphomas can induce kidney damage in several ways, including renal infiltration and the development of glomerulopathies. A case associated to the clinical onset of a mantle cell lymphoma w [...] ith lymphocytic infiltration into the renal parenchyma and mesangiocapillary glomerulonephritis without cryoglobulinemia was presented. This is the first case report that describes this association which evidences the different types of renal lesions in no Hodgkin lymphoma and the value of renal histological study for the diagnosis and prognosis of onco-hematologic diseases with kidney damage.

Raymed Antonio, Bacallao Méndez; Laura, López Marín; Agustín, Chong López; Betsy, Llerena Ferrer; Yudit, Chávez Muñoz; Yanisa de la Caridad, Castillo Álvarez.

2013-06-01

264

Remoção percutânea de fragmento de cateter intravascular: uma adaptação da caixa de ferramentas / Percutaneous removal of intravascular catheter fragment: an adaptation of the toolbox  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Languages: English, Portuguese Abstract in portuguese A fragmentação de um cateter intravascular foi primeiramente publicada em 1954 e, desde então, observamos notável evolução das técnicas de retirada de corpo estranho intravascular. A descrição pioneira de remoção não cirúrgica de corpo estranho data de 1964, com o relato da retirada de fragmento de [...] fio-guia com auxílio de um fórceps de biópsia para broncoscópio. Apesar da disponibilidade de variados dispositivos dedicados, por vezes, para se ter sucesso, é necessária a adaptação de materiais. Relatamos aqui o caso de uma portadora de cateter Port-a-Cath em veia subclávia esquerda, implantado 5 anos antes, que rompeu a porção intravascular durante sua retirada, tendo sido removido com sucesso por via percutânea. Abstract in english The first report of an intravascular catheter fragmentation was published in 1954 and ever since we have observed a remarkable evolution in the techniques of intravascular foreign body removal. The pioneer description of non-surgical foreign body removal dates back to 1964, with the report of a guid [...] ewire fragment withdrawal using a bronchoscopy biopsy forceps. Despite the availability of several dedicated devices, materials may have to be adapted at times to achieve technical success. We report the case of a patient with a Port-a-Cath catheter in the left subclavian vein, which had been placed 5 years before and whose intravascular portion was broken during withdrawal. It was successfully removed using the percutaneous approach.

Igor Ribeiro de Castro, Bienert; Rodolfo L. L. A. F., Chiozzi; Carlos E. C., Mota; João Saes, Braga; Rubio, Bombonato; Luís Junya, Kajita.

265

Linfoma de hodgkin extranodal: Reporte de un caso y revisión de la literatura  

Scientific Electronic Library Online (English)

Full Text Available SciELO Venezuela | Language: Spanish Abstract in spanish OBJETIVOS: Estudiar un paciente con diagnóstico de linfoma de Hodgkin extranodal, entre los subtipos extranodales esta el hepato-esplénico, frecuente en la 3ª y 4ª década de la vida, predomina en el sexo masculino, con sobrevida de 3 a 5 años. RESULTADOS: Paciente masculino 35 años, diagnóstico de e [...] ndocarditis bacteriana de válvula aórtica nativa. Referido a nuestro centro por persistir fiebre después de tratamiento por 31 días y múltiples antibióticos. Al egreso presenta elevación de transaminasas rango de 2-3 veces el valor normal, BT: 9 mg %, FA: 1 200 UI/L, examen funcional: fiebre de 8 meses previos al diagnóstico de endocarditis y pérdida de peso 4 - 5 kg. Ultrasonido abdominal: lesión de ocupación de espacio lóbulo hepático derecho, segmento VII y esplénica. Alfa feto proteína, antígeno carcino embrionario, CA 19.9; normales. Gastroscopia, colonoscopia, TAC de tórax y cuello normal. RMN: hepatomegalia, LOE hepático segmento VII de 6,5 cm. Esplenomegalia con LOE de 3,5 cm aspecto infiltrativo. RMN de columna lumbar: Lesiones multifocales en médula ósea de cuerpos vertebrales L1-L5. Biopsia hepática dirigida por tomografía: infiltración hepática por linfoma, diagnóstico corroborado por inmunohistoquímica, recibe tratamiento con quimioterapia normalizándose las pruebas hepáticas y desaparición de lesiones. CONCLUSIONES: El linfoma de Hodgkin hepato esplénico es infrecuente indica un curso clínico agresivo. A menudo es insuficiente el material diagnóstico de confirmación. La presentación clínica es variada. De evolución tórpida, en ocasiones diagnosticados post mortem ya que su baja incidencia no despierta sospecha en el clínico. Abstract in english OBJECTIVES: To study a patient with extranodal Hodgkin lymphomas in the extranodal subtypes there was hepato-esplenic. It’s frequent in 3ª and 4ª decade of life predominates, in males, and they have an expectancy of life between 3-5 years. RESULTS: 35 years old male patient, with the diagnosis of ba [...] cterial endocarditis of native aortic valve. Referred to our hospital because persist fever after receiving treatment for 30 more days, with multiple antibiotics. Before the discharge the serum enzymes began to raise 2-3 times the normal value, TB: 9 mg %, AP: 1200 UI/L, he referred to have fever during approximately 8 months, lost of weight of 4 - 5 kg. Abdominal echo: Hepatic lesion LOE in splenic segment VII and LOE. Ca19.9 alpha fetoprotein, carcinoembrionic antigen were negative, upper and lower endoscopy, thorax and neck TAC abdominal reported normal MRI: Hepatomegaly, hepatic lesion in segment VII splenomegaly with a 3.5 cm mass. Lumbar column MRI: Multifocal bony marrow injuries of vertebral bodies L1 to L5. A percutaneous hepatic biopsy was made: Hepatic infiltration by Hodgkin lymphoma. The diagnosis was corroborated by Immunohistochemestry Patient received chemotherapy with normalization of liver tests and disappear the lesions. CONCLUSIONS: Hepato-splenic Hodgkin lymphoma is infrequent and indicates aggressive clinical courses, often it is insufficient the material of diagnosis confirmation. Has a varied clinic presentation. It has a bad development and in multiple occasions diagnosed post mortem since its low incidence does not wake up suspicion clinical.

RORAYMA, VALERO; BEATRIZ, PERNALETE; LISBETH, ZURITA; ANDRY, RENDO; PEDRO, JIMÉNEZ; DALILA, ARANGUIBEL; FRANCISCO, PIMENTEL; JOSÉ LUÍS, MUJICA; JACINTO, LARA.

2007-05-01

266

Linfoma primário do sistema nervoso central Primary central nervous system lymphoma  

Directory of Open Access Journals (Sweden)

Full Text Available O linfoma primário do sistema nervoso central (LPSNC é um linfoma extralinfonodal que, ao diagnóstico, encontra-se restrito ao parênquima cerebral, às meninges e/ou cordão espinhal e/ou olhos. Sua incidência triplicou nas últimas três décadas para 0,4 casos por 100.000 habitantes, representando 4% dos tumores do sistema nervoso central (SNC. Embora pacientes infectados pelo HIV tenham 3.600 vezes maior risco para o desenvolvimento do LPSNC, a incidência não aumentou apenas neste grupo de pessoas. Dados sugerem reduções da incidência de LPSNC em pacientes infectados após a introdução de drogas anti-retrovirais. Cerca de 90% dos casos de LPSNC são classificados como linfoma difuso de grandes células B, 10% têm envolvimento ocular e 10% são HIV positivos. A apresentação clínica depende da localização tumoral, prevalecendo os sintomas neurológicos em detrimento aos sistêmicos. Os exames de tomografia computadorizada (TC e ressonância nuclear magnética (RNM são essenciais para o diagnóstico, porém o exame confirmatório deve ser o anatomopatológico. O estadiamento deve ser feito com exames de imagem e biópsia de medula óssea (BMO bilateral. Os principais fatores de mau prognóstico são: performance status do paciente acima de 1, idade superior a 60 anos, DHL elevada, hiperproteinorraquia e acometimento de área cerebral não hemisférica. Alguns fatores de prognóstico biológicos também podem influenciar na sobrevida, a exemplo da expressão de Bcl-6, que confere melhor prognóstico. O tratamento de escolha é a combinação de quimioterapia contendo altas doses de metotrexate e radioterapia (RDT. Devido às altas taxas de neurotoxicidade associada à RDT, seu uso tem ficado mais restrito aos pacientes idosos, e os recidivados ou refratários.Primary Central Nervous System lymphoma (PCNSL is an extranodal non-Hodgkin lymphoma in the brain, leptomeninges, spinal cord or eyes. The incidence of PCNSL increased approximately three-fold in the last decades. Nowadays, it represents 0.4 case per 100,000 people and accounts for 4% of all primary brain tumors. Although individuals infected with HIV have a 3,600-fold increased risk of developing PCNSL compared with the general population, the incidence has not increased only in AIDS group. Recent data suggest that the incidence of PCNSL declined in the AIDS group after the introduction of anti-retroviral drugs. Around 90% of PCNSL cases are classified as diffuse large B-cell lymphoma, 10% involve the eyes and 10% of patients are HIV positive. The clinical presentation depends on the location of the tumor with neurological rather than systemic symptoms. Computed tomography (CT and magnetic resonance imaging (RMI are essential in diagnosis, however the gold standard is tumor biopsy. Staging should be made with imaging and bilateral biopsy of bone marrow. The main poor prognosic parameters are performance status greater than 1, age older than 60 years, elevated DHL, high liquor protein concentration and tumor located within the deep regions of the brain. BCL-6 expression identified in the tumor confers a better prognosis. Currently, a combined therapy with high doses of methotrexate and whole-brain radiotherapy is the therapy of choice. Nowever, whole-brain radiotherapy should be carefully analyzed because neurotoxity is a frequent problem in the elderly and in relapsed and refractory patients.

Marcelo Bellesso

2008-02-01

267

Linfoma primário do sistema nervoso central / Primary central nervous system lymphoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese O linfoma primário do sistema nervoso central (LPSNC) é um linfoma extralinfonodal que, ao diagnóstico, encontra-se restrito ao parênquima cerebral, às meninges e/ou cordão espinhal e/ou olhos. Sua incidência triplicou nas últimas três décadas para 0,4 casos por 100.000 habitantes, representando 4% [...] dos tumores do sistema nervoso central (SNC). Embora pacientes infectados pelo HIV tenham 3.600 vezes maior risco para o desenvolvimento do LPSNC, a incidência não aumentou apenas neste grupo de pessoas. Dados sugerem reduções da incidência de LPSNC em pacientes infectados após a introdução de drogas anti-retrovirais. Cerca de 90% dos casos de LPSNC são classificados como linfoma difuso de grandes células B, 10% têm envolvimento ocular e 10% são HIV positivos. A apresentação clínica depende da localização tumoral, prevalecendo os sintomas neurológicos em detrimento aos sistêmicos. Os exames de tomografia computadorizada (TC) e ressonância nuclear magnética (RNM) são essenciais para o diagnóstico, porém o exame confirmatório deve ser o anatomopatológico. O estadiamento deve ser feito com exames de imagem e biópsia de medula óssea (BMO) bilateral. Os principais fatores de mau prognóstico são: performance status do paciente acima de 1, idade superior a 60 anos, DHL elevada, hiperproteinorraquia e acometimento de área cerebral não hemisférica. Alguns fatores de prognóstico biológicos também podem influenciar na sobrevida, a exemplo da expressão de Bcl-6, que confere melhor prognóstico. O tratamento de escolha é a combinação de quimioterapia contendo altas doses de metotrexate e radioterapia (RDT). Devido às altas taxas de neurotoxicidade associada à RDT, seu uso tem ficado mais restrito aos pacientes idosos, e os recidivados ou refratários. Abstract in english Primary Central Nervous System lymphoma (PCNSL) is an extranodal non-Hodgkin lymphoma in the brain, leptomeninges, spinal cord or eyes. The incidence of PCNSL increased approximately three-fold in the last decades. Nowadays, it represents 0.4 case per 100,000 people and accounts for 4% of all primar [...] y brain tumors. Although individuals infected with HIV have a 3,600-fold increased risk of developing PCNSL compared with the general population, the incidence has not increased only in AIDS group. Recent data suggest that the incidence of PCNSL declined in the AIDS group after the introduction of anti-retroviral drugs. Around 90% of PCNSL cases are classified as diffuse large B-cell lymphoma, 10% involve the eyes and 10% of patients are HIV positive. The clinical presentation depends on the location of the tumor with neurological rather than systemic symptoms. Computed tomography (CT) and magnetic resonance imaging (RMI) are essential in diagnosis, however the gold standard is tumor biopsy. Staging should be made with imaging and bilateral biopsy of bone marrow. The main poor prognosic parameters are performance status greater than 1, age older than 60 years, elevated DHL, high liquor protein concentration and tumor located within the deep regions of the brain. BCL-6 expression identified in the tumor confers a better prognosis. Currently, a combined therapy with high doses of methotrexate and whole-brain radiotherapy is the therapy of choice. Nowever, whole-brain radiotherapy should be carefully analyzed because neurotoxity is a frequent problem in the elderly and in relapsed and refractory patients.

Marcelo, Bellesso; Renata, Bizzetto; Juliana, Pereira; Beatriz, Beitler; Luis Fernando, Pracchia; Dalton A. S., Chamone.

2008-02-01

268

Insuficiencia suprarrenal causada por un linfoma no-Hodgking B primario suprarrenal: presentación de un caso y revisión de la literatura / Adrenal faillure caused by primary adrenal non-hodgking lymphoma: a case report and review of the literature  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish Presentamos el caso de un varón de 78 años que ingresa por un cuadro de debut de insuficiencia suprarrenal. Se realizó un estudio TC que mostró masas suprarrenales bilaterales de hasta 10 cm. Se completó estudio con biopsia percutanea de masa suprarrenal y biopsia de médula ósea, siendo diagnosticad [...] o de Linfoma no Hodgkin B difuso de células grandes primario suprarrenal con afectación suprarrenal bilateral. El paciente fue tratado con quimioterapia según esquema R-CHOP (Rituximab, Ciclofosfamida, Doxorrubicina liposomal, Vincristina y Prednisona). Tras 4 ciclos de quimioterapia se objetivo una respuesta parcial radiológica. Se suspendió la quimioterapia por toxicidad grado IV, completándose el tratamiento con RT sobre masa suprarrenal derecha. El paciente falleció por cuadro séptico pocos días después de finalizar la radioterapia, sin objetivarse progresión de la enfermedad. Abstract in english We report a case of 78-year old man who presented with symptoms of adrenal insufficiency. The computed tomography (CT) scan showed the presence of bilateral adrenal masses. A CT-scan guided needle biopsy revealed diffuse large- B cell lymphoma. The absence of pathological findings in clinical, bone [...] marrow and CT scan examinations supported the diagnosis of primary non- Hodgkin Lymphoma of the adrenal glands. The patient was treated with four cycles of R-CHOP chemotherapy with Rituximab, liposomal Doxorubicin, Cyclophosphamide, Vincristine and Prednisolone. At the end of fourth cycle there was radiological improvement but the chemotherapy was stopped because of IV grade toxicity. He completed treatment with radiotherapy of right adrenal mass. Few days after finishing radiation therapy the pacient died due to a disseminated infection. No progressive disease was founded.

B., Hernández Marín; V.M., Díaz Muñoz de la Espada; R., Álvarez Álvarez; S., Encinas García; P., Khosravi Shahi; R., Pérez Fernández; G., Pérez Manga.

2008-03-01

269

Linfoma malt gastrico: Presentación de un caso y revision de literatura  

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Full Text Available SciELO Venezuela | Language: Spanish Abstract in spanish Escolar masculino de 9 años, con mielomeningocele corregido e hidrocefalia, enfermedad actual de 3 años de evolución, caracterizada por epigastralgia intermitente, recibe tratamiento sin mejoría. Dos días antes del ingreso se asocian vómitos, hematemesis y fiebre. Al examen físico, signos de desnutr [...] ición crónica, anemia, hepatomegalia y dolor en epigastrio. Se realiza endoscopia digestiva superior, revela reflujo gastroesofágico, tumoración gástrica ulcerada y duodenitis inespecífica; se realizan ecosonograma abdominal, Rx esófago-estomago-duodeno contrastado y tomografía abdominal, donde se evidenció tumor en antro pilórico de 6 por 7 cm, estenosante y distensión gástrica. Recibe hemoderivados, por anemia aguda. Se realiza laparotomía exploradora, se evidencia gran tumoración friable, se extraen muestras para biopsia gástrica que reveló fragmento fibroadiposo con inflamación crónica y granulosa, reacción gigantocelular de tipo Langhans y tipo cuerpo extraño, necrosis y reagudización focal, las biopsias de ganglios, hígado y epiplón revelaron signos de inflamación crónica multifocal. Hemocultivos negativos, Anticore y Antigeno de superficie VHB negativos, PCR para CMV, estudio para BK y hongos negativos, examen de heces Blastocystis hominis, títulos de IgG contra Helicobacter pylori positivo 1.61 U/L, se inicio terapia con Metronidazol, Claritromicina y Omeprazol VEV, con remisión del tumor gástrico, todo lo cual sugiere Linfoma MALT gástrico o MALTOMA. Abstract in english Masculine student of 9 years, with mielomeningocele correted and hydrocephaly, present disease of 3 years of evolution, characterized by intermittent epigastralgia, receives treatment without improvement. Two days before the entrance vomits, hematemesis and fever are associated. To the physical exam [...] ination, signs of chronic undernourishment, anemia, hepatomegalia and pain in epigastrio. Superior digestive endoscopia is made, reveals gastroesfágico ebb tide, ulcerada gastric tumoración and unspecific duodenitis; ecosonograma abdominal, Rx resisted esophagus-stomach-duodeno and tomography abdominal are made, where it demonstrated tumor in pyloric caven of 6 by 7 cm, estenosante and gastric distension. It receives hemoderivados by acute anemia. Exploratory laparotomía is made, demonstrated great coldable tumoración, samples for gastric biopsy are extracted that revealed fibroadiposo fragment with chronic and granular inflammation, reaction to gigantocelular of Langhans type and type strange body, necrosis and focal reagudización, the biopsies of ganflia, liver and epiplón revealed signs of multifocal chronic inflammation. Hemocultivos negative, Anticore and Antigeno of surface VHB negative, negative PCR for CMV, study for BK and fungi, examination Blastocystis hominis and Giardia lamblia positive, titles of IgG and biopsy Helicobacter pylori positive , beginning therapy with Metronidazol, Clarotromicina and Omeprazol VEV, remission of the gastric tumor, which suggests gastric Linfoma MALT or MALTOMA.

Mariela, Hernández; Yubisay, Rosendo; Fabiola, Cordero; Margarita, Vásquez; Cesar, Delgado; Iraheny, Alvirez.

2010-09-01

270

Linfomas no Hodgkin: Área metropolitana de Bucaramanga Non-Hodgkin lymphomas from Bucaramanga metropolitan area  

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Full Text Available Introducción: Ninguna neoplasia ha generado tanta confusión en sus sistemas de clasificación como los linfomas no Hodgkin (LNH. Una correcta tipificación es necesaria para el diagnóstico, pronóstico y tratamiento. Objetivos: clasificar los LNH del registro poblacional de cáncer del área metropolitana de Bucaramanga. Pacientes y métodos: SSe realizó un estudio observacional de corte transversal, utilizando como población los pacientes con LNH del área metropolitana de Bucaramanga de enero de 2000 a diciembre de 2006. La información se obtuvo de las historias clínicas y de inmunohistoquímica en bloques de parafina. Se utilizo la clasificación de linfomas de la OMS. Resultados: Se estudiaron 320 pacientes y se encontró predominio de la enfermedad en la 6ª y 7ª década. La distribución por género fue mayor en hombres con 61,26% y mujeres 45,6%. El sitio anatómico de compromiso más frecuente fue ganglios cervicales con 25,6%. La mayoría expresaron antígenos B, 86,8%, y T, 1,8%. El subtipo más frecuente fue difuso de célula grande en el 29,6%. Conclusiones: La mayoría los LNH del área metropolitana de Bucaramanga son de linajes B, nodales y de célula grande difuso. Fue evidente el uso limitado de otras técnicas para la clasificación de estas neoplasias en nuestra región. Salud UIS 2011; 43(1: 39-47Introduction: There is not a neoplasm that has generated such confusion on its classification system such as the Non- Hodgkin's lymphoma. An adequate classification is necessary for diagnosis, prognostic and treatment. Objectives: To classify the NHL from the Bucaramanga metropolitan area poblational cancer registry. Patients and methods: An observational cross-sectional study was made, using as population the patients with NHL from the Bucaramanga metropolitan area from January 2000 until December 2006. The information was obtained from the clinical records and inmunohistochemistry in paraffin blocks. The WHO lymphoma classification was used. Results: 320 patients were studied and a predominance of the disease was found on the 6th and 7th decade of life. Gender distribution was higher in men with 61.26% and women 45.6%. The anatomical site more frequently affected were the cervical lymph nodes with 25.6%. Most of them expressed B antigens, 86.8%, and T, 1.8%. The most frequent subtype was diffuse large B cell in 29.6%. Conclusions: Most of the NHL from the Bucaramanga metropolitan area are nodal, of B lineage, and diffuse large cell subtype. The limited use of other techniques for the classification of these neoplasms in our region was evident. Salud UIS 2011; 43(1: 39-47.

Carlos Alberto García Ramírez

2011-04-01

271

Linfoma nasal de células T/NK / Nasal T/NK cell lymphoma  

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Full Text Available SciELO Spain | Language: Spanish Abstract in spanish El linfoma nasal de células T/ natural killer (NK) (LNT/NK), tras haber recibido múltiples denominaciones, ha sido definido y caracterizado en el año 2001 por la Organización Mundial de la Salud (OMS), basándose en una clasificación previa de la Revised European-American Lymphoma Classification (REA [...] L), de la manera en que se le conoce actualmente. Su incidencia en el mundo occidental es baja, mientras que en Asia supone el segundo grupo de linfomas más frecuente, tras los gastrointestinales. Se localiza preferentemente en las fosas nasales y senos maxilares, mostrando un curso clínico agresivo, definido por una destrucción de los tejidos circundantes. Su diagnóstico definitivo se realiza por medio de técnicas de hibridación in situ, llegando a la determinación de su inmunofenotipo. Se ha observado una frecuente asociación con el virus de Epstein-Barr (VEB). El pronóstico de esta enfermedad viene definido por el índice pronóstico internacional (IPI) y por el volumen alcanzado por el tumor. A pesar de ser radiosensible, su pronóstico es infausto, aconteciendo la muerte del paciente poco tiempo después del diagnóstico, generalmente como consecuencia de las complicaciones del tratamiento. Abstract in english Nasal T-cell and Natural Killer cell lymphoma (NT/NKL), having been given many names, was defined and described in the year 2001 by the World Health Organization (WHO), on the basis of a previous classification by the Revised European-American Lymphoma Classification (REAL) as it is known today. Its [...] incidence in the western world is low, while in Asia it represents the second most frequent group of lymphomas, followed by the gastrointestinal [lymphoma]. It is typically located in the nasal cavity and maxillary sinuses. It is associated with an aggressive clinical course, characterized by the destruction of surrounding tissue. The definitive diagnosis is made by means of in situ hybridization techniques, in order to determine the immunophenotype. Its association with the Epstein-Barr virus (EBV) has frequently been observed. The prognosis of this disease is determined by the International Prognosis Index (IPI) and by the size of the tumor. In spite of being responsive to irradiation therapy, its prognosis is gloomy, and the death of the patient occurs shortly after the diagnosis, generally as a result of treatment complications.

A., Torre Iturraspe; S., Llorente Pendás; J.C. de, Vicente Rodríguez; L.M., Junquera Gutiérrez; J.S., López-Arranz Arranz.

2005-04-01

272

Aspectos clínicos e histopatológicos do linfoma nasossinusal / Clinical and histopathological aspects of the sinonasal lymphoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Os linfomas do trato nasossinusal são neoplasias incomuns, que reconhecidamente causam importantes lesões destrutivas no nariz e terço médio da face. Sua raridade pode levar os profissionais da área médica a erros no diagnóstico clínico, além de representar um verdadeiro desafio aos patologistas, po [...] r sua natureza inflamatória. OBJETIVO: O objetivo deste estudo é determinar os aspectos clínicos e histopatológicos do linfoma não-Hodgkin (LNH) do trato nasossinusal, correlacionando sítio tumoral e comportamento biológico com os subtipos do LNH. FORMA DE ESTUDO: Estudo de série. MATERIAL E MÉTODO: Foi realizada uma análise retrospectiva que incluiu 7 pacientes atendidos no ambulatório do serviço de otorrinolaringologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, no período de 1985 a 2003. RESULTADOS: As linhagens de células B e T/NK têm comportamento biológico diferente, assim como o sítio e apresentação clínica, sendo o diagnóstico histopatológico de extrema importância. CONCLUSÃO: A biópsia realizada adequadamente favorecerá um diagnóstico mais precoce e preciso, instituindo rapidamente a terapêutica adequada e melhorando o prognóstico e a sobrevida destes pacientes. Abstract in english Non-Hodgkin's lymphoma of the sinonasal tract is relatively uncommon and is now recognized as an important cause of destructive lesions of the nose and midface, which show a progressive course. It is this rarity that may cause clinicians to dismiss them as a benign inflammatory infiltrate and may pr [...] esent a considerable diagnostic challenge to the pathologist. AIM: The objective of the present study was to identify epidemiological, clinical and histopathological aspects of the non-Hodgkin's lymphoma of the sinonasal tract, correlation site and natural history with histopathological types. STUDY DESIGN: Series review. MATERIAL AND METHOD: The study group consisted of seven patients (4 men and 3 women) with clinical diagnosis of sinonasal non-Hodgkin lymphoma seen at the Clinic of the Division of Otorhinolaryngology, University of Sao Paulo, between 1985 and 2003. Patients age ranged from 22 to 54 years (mean: 38,2 years). The patients data obtained were analyzed regarding epidemiological, clinical, therapeutic and outcome factors. RESULTS: The site of tumor, clinical manifestations and natural history of the sinonasal lymphomas of the B-cell phenotype and T/NK cell phenotype were different, so the histopathological diagnosis is very important. CONCLUSION: The diagnosis can be extremely difficult. Biopsy specimens were necessary to establish the diagnosis of each patient. Early diagnosis and efficient therapy must be developed to improve patient outcome.

Bernardo C., Araújo Filho; Flavio A., Sakae; Marcus M., Lessa; Maura C. das, Neves; Richard L., Voegels; Ossamu, Butugan.

2004-06-01

273

A short contemporary history of disseminated intravascular coagulation.  

Science.gov (United States)

Disseminated intravascular coagulation (DIC) is a syndrome characterized by systemic intravascular activation of coagulation, leading to a widespread deposition of fibrin in the circulation. There is ample experimental and pathological evidence that the fibrin deposition contributes to multiple organ failure. The massive and ongoing activation of coagulation may result in depletion of platelets and coagulation factors, which may cause bleeding (consumption coagulopathy). The syndrome of DIC is well known in the medical literature for centuries, although a more precise description of the underlying mechanisms had to await the 20th century. Initial ideas on a role of the contact activation system as the primary trigger for the systemic activation of coagulation as well as a presumed hyperfibrinolytic response in DIC have been found to be misconceptions. Experimental and clinical evidence now indicate that the initiation of coagulation in DIC is caused by tissue factor expression, which in combination with downregulated physiological anticoagulant pathways and impaired fibrinolysis leads to widespread fibrin deposition. In addition, an extensive bidirectional interaction between coagulation and inflammation may further contribute to the pathogenesis of DIC. PMID:25377321

Levi, Marcel; van der Poll, Tom

2014-11-01

274

Improving quantification of intravascular fluorescence imaging using structural information  

International Nuclear Information System (INIS)

Intravascular near-infrared fluorescence (iNIRF) imaging can enable the in vivo visualization of biomarkers of vascular pathology, including high-risk plaques. The technique resolves the bio-distribution of systemically administered fluorescent probes with molecular specificity in the vessel wall. However, the geometrical variations that may occur in the distance between fibre-tip and vessel wall can lead to signal intensity variations and challenge quantification. Herein we examined whether the use of anatomical information of the cross-section vessel morphology, obtained from co-registered intravascular ultrasound (IVUS), can lead to quantification improvements when fibre-tip and vessel wall distance variations are present. The algorithm developed employs a photon propagation model derived from phantom experiments that is used to calculate the relative attenuation of fluorescence signals as they are collected over 360° along the vessel wall, and utilizes it to restore accurate fluorescence readings. The findings herein point to quantification improvements when employing hybrid iNIRF, with possible implications to the clinical detection of high-risk plaques or blood vessel theranostics. (paper)

275

Retinal and choroidal intravascular spectral-domain optical coherence tomography  

DEFF Research Database (Denmark)

Purpose:? To examine retinal and choroidal blood vessels using spectral-domain optical coherence tomography (SD-OCT). Methods:? Retrospective case series. Results:? Scans through retinal blood vessels in healthy subjects demonstrated vessel wall reflexes and a tri-layer profile of the blood column on longitudinal scans and a figure-of-eight configuration on cross-sectional scans. Intravascular reflectivity decreased with increasingly oblique angles of observation and was absent when blood flow was parallel to the line of sight. The high blood flow in the choroidal vessels in healthy subjects and the low flow in the retinal vessels in patients with ocular ischaemic syndrome and central retinal artery occlusion were both associated with lower reflectivity of the blood and an unstructured intravascular SD-OCT profile. Discussion:? This qualitative in vivo study found a characteristically structured SD-OCT profile of the blood column in retinal vessels with normal blood flow. Both structure and total reflectivityfaded when blood flow was lower or higher than normal or at oblique angles to the line of sight. In conclusion, SD-OCT scans of the vessels in the posterior pole of the eye may assist the clinical assessment of gross abnormalities of ocular blood flow, e.g. in carotid artery stenosis.

Willerslev, Anne; Li, Xiao Q

2013-01-01

276

Influence of intravascular molecular weight of hydroxyethyl starch on platelets.  

Science.gov (United States)

Complications concerning the blood coagulation have been observed repeatedly after administration of highly substituted, high molecular weight hydroxyethyl starch (HES), but it has not been examined as to how intravascular molecular weight and degree of substitution of HES influence platelet number and volume after repeated administration. Thirty patients with cerebrovascular diseases were treated for 10 days with hemodilution. 500 to 1500 ml of HES 200/0.62(n=10), HES 200/0.5(n=10) or HES 40/0.5(n=10) were infused daily. During the first days, the number of platelets was not lowered beyond the dilution effect, but at the end of the therapy the number of platelets had increased in all 3 groups beyond the initial value. Platelet volume was lowered significantly in the 3 groups. HES 200/0.62 caused the largest drop in platelet volume (-10%, pplatelets or are phagocytized by them. The larger platelets are then broken down and, to compensate the loss, more thrombocytes are released. A correlation between the molecular weight of HES and the breakdown rate of the platelets can be suspected, because HES 200/0.62 has the highest intravascular mean molecular weight(121 kD) and the largest effect on platelet volume. PMID:8598237

Treib, J; Haass, A; Pindur, G; Treib, W; Wenzel, E; Schimrigk, K

1996-03-01

277

Capability of three types of biodegradable intravascular stent  

International Nuclear Information System (INIS)

Objective: To develop and evaluate three types of biodegradable intravascular stent (BIS) with biodegradable materials of poly-L-acid (PLLA) or Polyl (l-lactide-co-glycolide) (PLLGA). Methods: Forty-five spiral BISs (15 BISs for each type) were prepared with PLLA (153 kDa, type A), PLLGA(141 kDa, type B), and PLLGA (contains paclitaxel, 141 kDa, type C). The physical and mechanical properties of the BIS were tested, including radial force, overlay rate, longitudinal shrinkage rate, and rate of expansion. Results: The radial force of three types BIS was 15.7%/0.006 Mpa (type A), 16.3%/0.006 Mpa (type B), and 16.4%/0.006 Mpa (type C). The radial force of type A was greater than that of type B and C (P<0.05). The longitudinal shrinkage rate and overlay rate of type A were lower than that of the others (10% vs 12%, 16% vs 18%, P<0.05). Conclusion: The mechanical characteristics of three types BIS could fulfill the criterion of physical, mechanical and chemical properties for intravascular stent implantation. Characteristics of type A are superior to that of type B or type C. (authors)

278

Late adverse reactions to intravascular iodinated contrast media  

International Nuclear Information System (INIS)

Late adverse reactions to intravascular iodinated contrast media are defined as reactions occurring 1 h to 1 week after contrast medium injection. They have received increasing interest over the past decade, but their prevalence remains uncertain and their pathophysiology is not fully understood. The Contrast Media Safety Committee of the European Society of Urogenital Radiology decided to review the literature and to issue guidelines. An extensive literature search was carried out and summarized in a report. Based on the available information, simple guidelines have been drawn up. The report and guidelines were discussed at the 8th European Symposium on Urogenital Radiology in Genoa. Late adverse reactions after intravascular iodinated contrast medium include symptoms such as nausea, vomiting, headache, itching, skin rash, musculoskeletal pain, and fever. A significant proportion of these reactions is unrelated to the contrast medium; however, allergy-like skin reactions are well-documented side effects of contrast media with an incidence of approximately 2%. Late reactions appear to be commoner after non-ionic dimers. The majority of late skin reactions after contrast medium exposure are probably T-cell-mediated allergic reactions. Patients at increased risk of late skin reactions are those with a history of previous contrast medium reaction and those on interleukin-2 treatment. Most skin reactions are self-limiting and resolve within a week. Management is symptomatlve within a week. Management is symptomatic and similar to the management of other drug-induced skin reactions. (orig.)

279

Thyroid Storm Complicated by Bicytopenia and Disseminated Intravascular Coagulation  

Science.gov (United States)

Patient: Male, 23 Final Diagnosis: Thyroid storm Symptoms: Delirium • diarrhea • fever • hypertension • hyperventilation • tachycardia • weight loss Medication: — Clinical Procedure: — Specialty: Endocrinology and Metabolic Objective: Unusual clinical course Background: The clinical presentation of thyroid storm includes fever, tachycardia, hypertension, and neurological abnormalities. It is a serious condition with a high mortality rate. Furthermore, some other complications affect the clinical course of thyroid storm. Although it is reported that prognosis is poor when thyroid storm is complicated by disseminated intravascular coagulation syndrome (DIC) and leukopenia, reports of such cases are rare. Case Report: A 23-year-old man presented with delirium, high pyrexia, diarrhea, and weight loss of 18 kg over 2 months. According to the criteria of Burch and Wartofsky, he was diagnosed with thyroid storm on the basis of his symptom-complex and laboratory data that confirmed the presence of hyperthyroidism. Investigations also found leukopenia, thrombocytopenia, and disseminated intravascular coagulation, all of which are very rare complications of thyroid storm. We successfully treated him with combined therapy including anti-thyroid medication, despite leukopenia. Conclusions: Early diagnosis and treatment are essential in ensuring a good outcome for patients with this rare combination of medical problems. PMID:25072662

Tokushima, Yoshinori; Sakanishi, Yuta; Nagae, Kou; Tokushima, Midori; Tago, Masaki; Tomonaga, Motosuke; Yoshioka, Tsuneaki; Hyakutake, Masaki; Sugioka, Takashi; Yamashita, Shu-ichi

2014-01-01

280

Late adverse reactions to intravascular iodinated contrast media  

Energy Technology Data Exchange (ETDEWEB)

Late adverse reactions to intravascular iodinated contrast media are defined as reactions occurring 1 h to 1 week after contrast medium injection. They have received increasing interest over the past decade, but their prevalence remains uncertain and their pathophysiology is not fully understood. The Contrast Media Safety Committee of the European Society of Urogenital Radiology decided to review the literature and to issue guidelines. An extensive literature search was carried out and summarized in a report. Based on the available information, simple guidelines have been drawn up. The report and guidelines were discussed at the 8th European Symposium on Urogenital Radiology in Genoa. Late adverse reactions after intravascular iodinated contrast medium include symptoms such as nausea, vomiting, headache, itching, skin rash, musculoskeletal pain, and fever. A significant proportion of these reactions is unrelated to the contrast medium; however, allergy-like skin reactions are well-documented side effects of contrast media with an incidence of approximately 2%. Late reactions appear to be commoner after non-ionic dimers. The majority of late skin reactions after contrast medium exposure are probably T-cell-mediated allergic reactions. Patients at increased risk of late skin reactions are those with a history of previous contrast medium reaction and those on interleukin-2 treatment. Most skin reactions are self-limiting and resolve within a week. Management is symptomatic and similar to the management of other drug-induced skin reactions. (orig.)

Webb, Judith A.W. [Department of Diagnostic Imaging, St. Bartholomew' s Hospital, London EC1A 7BE (United Kingdom); Stacul, Fulvio [Institute of Radiology, Ospedale di Cattinara, 34149 Trieste (Italy); Thomsen, Henrik S. [Department of Diagnostic Radiology 54E2, Copenhagen University Hospital at Herlev, Herlev Ringvej 75, 2730 Herlev (Denmark); Morcos, Sameh K. [Department of Diagnostic Imaging, Northern General Hospital, Sheffield Teaching Hospitals NHS Trust, Sheffield S5 7AU (United Kingdom)

2003-01-01

281

Primary effusion lymphoma presenting as a cutaneous intravascular lymphoma.  

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Primary effusion lymphoma (PEL) is a rare and aggressive lymphoma that arises in the context of immunosuppression and is characterized by co-infection with Epstein-Barr virus (EBV) and human herpesvirus-8/Kaposi sarcoma-associated herpesvirus (HHV-8/KSHV). It was originally described as arising in body cavity effusions, but presentation as a mass lesion (extracavitary PEL) is now recognized. Here, we describe a case of PEL with an initial presentation as an intravascular lymphoma with associated skin lesions. The patient was a 53-year-old man with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) who presented with fevers, weight loss and skin lesions concerning for Kaposi sarcoma (KS). A skin biopsy revealed no evidence of KS; however, dermal vessels contained large atypical cells that expressed CD31 and plasma cell markers but lacked most B- and T-cell antigens. The atypical cells expressed EBV and HHV-8. The patient subsequently developed a malignant pleural effusion containing the same neoplastic cell population. The findings in this case highlight the potential for unusual intravascular presentations of PEL in the skin as well as the importance of pursuing microscopic diagnosis of skin lesions in immunosuppressed patients. PMID:25355615

Crane, Genevieve M; Xian, Rena R; Burns, Kathleen H; Borowitz, Michael J; Duffield, Amy S; Taube, Janis M

2014-12-01

282

Alterações histológicas e imunoistoquímicas em pâncreas de ratos normais e diabéticos tratados com Syzygium cumini  

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Avaliou-se o efeito da administração oral do extrato da casca de Syzygium cumini sobre o pâncreas de ratos normais e diabéticos. Os animais foram divididos em grupo controle (C), controle tratado (CT), diabético controle (DC) e diabético tratado (DT). Os tratados receberam dose diária de 1g kg-1 de peso vivo, durante 30 dias. Os animais foram submetidos à eutanásia e o pâncreas retirado para análise histológica e imunoistoquímica para insulina. Neste estudo observou-se uma diminu...

Schossler Deila Rosely Carneiro; Mazzanti Cinthia Melazzo; Luz Sônia Cristina Almeida da; Filappi Andreane; Prestes Danívia; Silveira Aron Ferreira da; Cecim Marcelo

2004-01-01

283

Linfoma T subcutâneo do tipo paniculite: relato de um caso acometendo paciente pediátrico Subcutaneous panniculitic T cell lymphoma: a case report affecting a child  

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Full Text Available Os autores relatam um caso de linfoma T subcutâneo do tipo paniculite em uma paciente feminina de 3 anos, apresentando havia um mês múltiplos nódulos subcutâneos, indolores, disseminados no abdome, região peitoral e cervical. Ao exame histopatológico, evidenciou-se um linfoma T infiltrando tecido adiposo subcutâneo. Os linfomas T subcutâneos representam uma entidade clinicopatológica distinta, sendo raro o acometimento pediátrico.We report a case of lypotrophic lymphoma affecting a 3-year-old child with 1-month history of nontender subcutaneous nodules disseminated throughout the abdomen, chest and cervical region. Histological examination showed a T-cell lymphoma affecting the subcutaneous tissue. Subcutaneous panniculitis-like T-cell lymphoma is an unusual cutaneous T-cell lymphoma that rarely affects pediatric patients.

Lúcia de Noronha

2001-01-01

284

Linfoma primario del sistema nervioso central en un paciente con sida  

Scientific Electronic Library Online (English)

Full Text Available SciELO Ury | Language: Spanish Abstract in spanish Se presenta un caso clínico de linfoma primario del sistema nervioso central (LPSNC) en una paciente con infección por virus de la inmunodeficiencia humana (VIH) en estadio sida. En este caso particular se destaca la confirmación por histopatología mediante intervención neuroquirúrgica de una lesión [...] ocupante de espacio (LOE), lo que permitió instalar tratamiento oncoespecífico y terapia antirretroviral, lográndose buena evolución clínica. El objetivo de la presente comunicación es realizar una revisión y actualización bibliográfica del LPSNC en pacientes VIH destacando principalmente el aporte de los métodos diagnósticos y terapéuticos. Abstract in english Summary A clinical case of a primary central nervous system (PLCNS) lymphoma in a woman with HIV, AIDS stage. After neurosurgery an injury in a site was confirmed thus an oncologic treatment and antiretroviral therapy were conducted achieving acceptable results. We aim at reviewing and updating PLCN [...] S bibliography in patients with HIV taking into consideration diagnostic and therapeutic methods

Susana, Cabrera; Gabriel, Krygier; Aníbal, Dutra; Alejandra, Sosa; Karina, Lombardo; Eduardo, Savio; Ronald, Salamano; Saúl, Wajskopf; Graciela, Mañana.

2005-03-01

285

Diagnóstico de linfoma cerebral primario por el oftalmólogo Primary cerebral lymphoma diagnosed by the ophthalmologist  

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Full Text Available Caso clínico: Paciente varón de 20 años, VIH positivo, con miodesopsias en ambos ojos de 2 semanas de evolución. El examen fundoscópico reveló edema de papila bilateral con hemorragias peripapilares en llama. El estudio de neuroimagen mostró la presencia de una masa cerebral en el lóbulo parietal izquierdo. La biopsia confirmó el diagnóstico de neoplasia de estirpe linfoide. Discusión: El linfoma primario es la neoplasia más frecuente del sistema nervioso central (SNC en pacientes con sida (síndrome de inmudeficiencia adquirida aunque la terapia antirretroviral de gran actividad ha disminuido su incidencia. Destacamos el papel del oftalmólogo en el diagnóstico de neoplasias del SNC.Case report: A 20-year-old male, HIV positive, with myodesopsias (floaters in both eyes for two weeks. Fundus examination revealed bilateral papillary oedema with peripapilar flame-shaped haemorrhages. The neuroimaging tests showed a cerebral mass in the left parietal lobe. The biopsy confirmed the diagnosis of lymphoid neoplasm. Discussion: Primary lymphoma is the most common malignancy of the central nervous system (CNS in AIDS patients, although highly active antiretroviral therapy has reduced its incidence. The ophthalmologist plays an essential role in the diagnosis of CNS neoplasm.

M. Castro-Rebollo

2010-01-01

286

Leucemia linfóide crônica e linfoma linfocítico de pequenas células / Chronic lymphocytic leukemia and small lymphocytic lymphoma  

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Full Text Available O linfoma linfocítico de pequenas células (LLPC) é considerado uma variante tumoral da leucemia linfocítica crônica e, por conseguinte, a mesma doença. Existem similaridades clínicas, morfológicas, imunofenotípicas e genéticas que parecem resistir até mesmo a uma análise mais aprofundada com o instr [...] umental técnico atualmente disponível para o estudo da biologia molecular. Talvez o refinamento das técnicas de análise da expressão de multiplos genes, incluindo genes para microRNAs, tanto das células malignas quanto das remanescentes benignas do microambiente, e os avanços no conhecimento de determinantes da diferenciação celular possam, em um futuro próximo, esclarecer afinal se LLPC e LLC são doenças diferentes. Abstract in english Small lymphocytic lymphoma (SLL) and chronic lymphocytic leukemia (CLL) are thought to be different expressions of the same disease. There are clinical, morphological, immuno-phenotypical and genotypical similarities that seem to resist even to advanced molecular biology techniques. It still needs t [...] o be defined, through a more refined understanding of the gene profile expression and microRNA biology of the malignant and surrounding micro-environment benign cells and a better understanding of the new paradigms of cell differentiation relativity, if SLL and CLL are different diseases.

Lucia M. R., Silla.

2005-12-01

287

Linfoma de Hodgkin y no Hodgkin durante la gestación: a propósito de dos casos  

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Full Text Available SciELO Chile | Language: Spanish Abstract in spanish Las neoplasias hematológicas en el embarazo conllevan un gran riesgo para la madre y el feto. El linfoma, Hodgkin (LH) y no Hodgkin (LNH), es la cuarta causa más frecuente de cáncer diagnosticado en el embarazo. El tipo más frecuente es el LH, mientras que la incidencia de LNH es muy baja. Presentam [...] os dos casos de gestantes de 29 y 25 años, diagnosticadas en el segundo trimestre de la gestación de LNH mediastínico de células B y LH tipo esclerosis nodular respectivamente. Ambas fueron tratadas con quimioterapia desde el diagnóstico hasta dos semanas antes del parto, con buen resultado perinatal. Abstract in english Haematological cancer in pregnancy poses a substantial risk to both, mother and fetus. Lymphoma, including Hodgkin's lymphoma (HL) and Non-Hodgkin's lymphoma (NHL), is the fourth most frequent malignancy diagnosed during pregnancy. The most common type of lymphoma in this setting is HL, and the inci [...] dence of pregnancy associated NHL is very low. In this report we describe two cases of a 29-year-old woman and a 25-year-old woman both in the second trimester of pregnancy, diagnosed with mediastinal B-cell NHL and nodular-sclerosis HL respectively. They were managed with chemotherapy since the diagnosis as far as two weeks before the delivery, both with a successful fetal outcome.

Beatriz, Rojas P; Matilde, Perella A; Aldonza, Ania L; Teresa, Arribas M; Lorena, Guardia D; Isabel, González B; Belén, Carazo H.

2014-10-01

288

Linfoma intestinal de células T e doença celíaca / Intestinal t-cell lymphoma and celiac disease  

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Full Text Available SciELO Portugal | Language: Portuguese Abstract in portuguese O linfoma de células T associado a enteropatia (LTAE) é uma neoplasia rara, com origem nos linfócitos T intestinais intraepiteliais e que está frequentemente associado a doença celíaca (DC). Os autores relatam o caso de um doente com quadro de desconforto abdominal, perda de peso acentuada, intolerâ [...] ncia ao glúten, com anticorpos antigliadina positivos e múltiplas adenomegálias mesentéricas, ao qual foi diagnosticado DC e LTAE após ressecção cirúrgica de segmento do jejuno com cerca de 15 centímetros, envolvido por implantes tumorais. Com a descrição deste caso, salienta-se a dificuldade no diagnóstico clínico e anatomopatológico desta entidade, alicerçando o tema numa revisão da literatura. Abstract in english Enteropathy associated T-cell lymphoma (EATL) is a rare tumor. It develops in intestinal intra-epithelial T-cells and is commonly associated with celiac disease (CD). The authors report a patient presenting with abdominal discomfort, weight loss, intolerance to gluten, positive gliadin antibodies an [...] d mesenteric lymph node enlargement. CD with EALT was diagnosed after surgical resection of 15 centimeters of jejuno with tumor implants. This case brings out to discussion the difficulty of clinical and histological diagnosis of this entity based on a literature review.

Flávia, Semedo; Cláudio, Quintaneiro; Rosário Santos, Silva; Luísa, Loureiro; Raquel, Dias; Fátima, Guedes; Amélia, Pereira.

2013-05-01

289

Leucemia linfóide crônica e linfoma linfocítico de pequenas células Chronic lymphocytic leukemia and small lymphocytic lymphoma  

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Full Text Available O linfoma linfocítico de pequenas células (LLPC é considerado uma variante tumoral da leucemia linfocítica crônica e, por conseguinte, a mesma doença. Existem similaridades clínicas, morfológicas, imunofenotípicas e genéticas que parecem resistir até mesmo a uma análise mais aprofundada com o instrumental técnico atualmente disponível para o estudo da biologia molecular. Talvez o refinamento das técnicas de análise da expressão de multiplos genes, incluindo genes para microRNAs, tanto das células malignas quanto das remanescentes benignas do microambiente, e os avanços no conhecimento de determinantes da diferenciação celular possam, em um futuro próximo, esclarecer afinal se LLPC e LLC são doenças diferentes.Small lymphocytic lymphoma (SLL and chronic lymphocytic leukemia (CLL are thought to be different expressions of the same disease. There are clinical, morphological, immuno-phenotypical and genotypical similarities that seem to resist even to advanced molecular biology techniques. It still needs to be defined, through a more refined understanding of the gene profile expression and microRNA biology of the malignant and surrounding micro-environment benign cells and a better understanding of the new paradigms of cell differentiation relativity, if SLL and CLL are different diseases.

Lucia M. R. Silla

2005-12-01

290

Linfoma no Hodgkin tipo anaplásico de localización cutánea: Presentación de 1 caso  

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Full Text Available Se describió un caso de linfoma maligno no Hodgkin tipo anaplásico (LMnH, de localización principal en la piel de la región torácica posterior de un paciente de 56 años de edad, masculino, raza negra, proveniente de la provincia de Manica, Mozambique. El cuadro lesional y topográfico hizo pensar en otros tipos de tumores o micosis profundas. Se corroboró el diagnóstico de LMnH tipo anaplásico de grandes células, CD 30+, por la histología, inmunocitoquímica y la inmunohistoquímica. Se inició el tratamiento con poliquimioterapia, CHOP (ciclofosfamida, doxorrubicina, vincristina y prednisona, 6 ciclos con intervalos de 3 semanas entre ellos. Se logró evolución satisfactoria, la totalidad de las lesiones dermatológicas involucionaron. Actualmente, se encuentra en observación.The case of a 56-year-old black male patient from the province of Manica, Mozambique, that presented an anaplastic malignant non-Hodgkin’s lymphoma mainly located in the skin of the posterior thoracic region, was described. The lesion and topographic picture made us think about other types of tumors or deep mycosis. The diagnosis of CD 30+ anaplastic malignant large-cell non-Hodgkin’s lymphoma was corroborated by histology, immunocytochemistry and immunohistochemistry. The treatment was initiated with combination chemotherapy, CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone, 6 cycles at intervals of 3 weeks among them. A satisfactory evolution was attained. It was observed an involution of all the skin lesions. At present, this patient is under observation.

María Dolores Castillo Menéndez

2003-03-01

291

Linfoma subcutâneo de células T paniculite-símile Subcutaneous panniculitis-like T-cell lymphoma  

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Full Text Available Linfoma subcutâneo de células T paniculite-símile foi recentemente reconhecido como entidade clínico-patológica. Paciente do sexo feminino, 17 anos, relatou nodosidades eritêmato-violáceas e depressões nos membros e abdome há três anos e discreta perda ponderal, sem outros sintomas gerais. Adenomegalia, visceromegalias e infiltração da medula óssea estavam ausentes, e a histopatologia da pele mostrou densa infiltração de linfócitos atípicos CD3/CD8 no subcutâneo. A quimioterapia interrompeu o surgimento de novas lesões com remissão das pré-existentes no seguimento de oito meses. Aspectos imunofenotípicos e moleculares são relevantes para elucidação diagnóstica e avaliação do prognóstico.Subcutaneous panniculitis-like T-cell lymphoma is extremely rare and has recently been recognized as a clinicopathological entity. Young female, 17 years old, has complained of subcutaneous nodules and plaques in the limbs and abdomen for three years, accompanied of mild weight loss without other constitutional symptoms. Nodal, visceral and bone marrow involvement was absent, and subcutaneous CD3/CD8 atypical lymphocyte infiltration was observed in the skin sample. Chemotherapy interrupted the onset of new lesions and led to remission in the 8-month follow-up. Immunophenotypic and molecular aspects were relevant to the diagnosis and as prognosis makers.

Renato Soriani Paschoal

2009-08-01

292

Neuroimagen del linfoma primario del sistema nervioso central en pacientes inmunodeprimidos  

Scientific Electronic Library Online (English)

Full Text Available SciELO Argentina | Language: Spanish Abstract in spanish Objetivos: El linfoma primario del sistema nervioso central (LPSNC) es una entidad rara con un pronóstico fatal. Dado el aumento en el número de casos con inmunosupresión adquirida, nuestros objetivos son estudiar las características epidemiológicas y neurorradiológicas de aquellos pacientes inmunod [...] eprimidos con diagnóstico de LPSNC con afectación cerebral e investigar si existen diferencias entre los pacientes con el virus de la inmunodefi ciencia humana (VIH) positivo y negativo. Materiales y métodos: Se realizó un estudio descriptivo y retrospectivo de los pacientes inmunodeprimidos con afectación cerebral por LPSNC, diagnosticados durante los últimos 13 años en 2 hospitales de referencia. Se evaluaron múltiples variables. El nivel de significación estadística utilizado fue p Abstract in english Purposes: Primary central nervous system lymphoma (PCNSL) is a rare tumour with poor prognosis. Due to the increased number of patients with acquired immunodeficiency, our purposes are to describe epidemiological and imaging findings in immunodeficient patients with PCNSL of the brain and to study t [...] he differences between HIV-positive and HIV-negative patients with PCNSL. Materials and methods: A retrospective, descriptive study was performed with immunodeficient patients diagnosed of PCNSL of the brain during the last 13 years in two reference hospitals. Twenty-one patients fulfilled the inclusion criteria. Multiple variables were evaluated. Significance was defined as p

C, Sobrido Sampedro; J.D, Corroto; M, Arias González; A, Iglesias Castañón; J, Corroto Murua; J.M, Pumar Cebreiro.

2014-04-01

293

Capacitação de enfermeiros para uso da ultrassonografia na punção intravascular periférica Capacitación de enfermeros en el uso de la ultrasonografía en la punción intravascular periférica Training of nurses in the use of intravascular ultrasound in peripheral puncture  

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Full Text Available Este artigo relata a estratégia de capacitação de enfermeiros para uso da ultrassonografia vascular na obtenção do acesso vascular periférico. O programa foi composto por intervenções educacionais teóricas e práticas desenvolvidas em um período de seis meses. As estratégias foram elaboradas e implementadas por dois enfermeiros especialistas em terapia intravascular, um médico especialista em ultrassonografia vascular e um engenheiro biomédico. Oito enfermeiros participaram da capacitação e, ao final, os conhecimentos, as competências e habilidades adquiridas na identificação de artérias, veias, fluxo sanguíneo e posicionamento de cateteres foram avaliados. A estratégia possibilitou que enfermeiros pediatras adquirissem competências capazes de promover intervenções inovadoras na punção intravascular periférica.Este artículo relata la estrategia de capacitación de enfermeros en el uso de la ultrasonografía vascular en la obtención del acceso vascular periférico. El programa estuvo compuesto por intervenciones educacionales teóricas y prácticas desarrolladas en un período de seis meses. Las estrategias fueron elaboradas e implementadas por dos enfermeros especialistas en terapia intravascular, un médico especialista en ultrasonografía vascular y, un ingeniero biomédico. Ocho enfermeros participaron de la capacitación. Al final, los conocimientos, las competencias y habilidades adquiridas en la identificación de arterias, venas, flujo sanguíneo y posición de catéteres, fueron evaluados. La estrategia posibilitó que los enfermeros pediatras adquiriesen competencias capaces de promover intervenciones innovadoras en la punción intravascular periférica.The objective was to explain, to the nurses training, procedures using vascular ultrasound for obtaining peripheral vascular access. The program consisted of theoretical and practical educational interventions developed over a period of six months. The strategies were developed and implemented by two nurses specialized in intravascular therapy, one doctor specialized in vascular ultrasound and, one biomedical engineer. Eight nurses participated in the training. The knowledge, skills and abilities acquired in the identification of arteries, veins, blood flow and catheter position, were evaluated. The strategy will enable that the pediatrician nurses acquiring skills to promote innovative interventions in peripheral intravascular puncture.

Ariane Ferreira Machado Avelar

2010-06-01

294

Fiebre de origen desconocido: Forma de presentación de los linfomas malignos / Malignant lymphomas presenting as fever of unknown origin  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish Objetivo: Los linfomas malignos constituyen la primera causa de fiebre de origen desconocido (FOD) dentro de la categoría de las neoplasias. Se realizó este estudio con el objetivo de determinar los hallazgos clínicos y aquellas investigaciones que contribuyeron al diagnóstico de dichos tumores. Mét [...] odo: Se realizó un estudio descriptivo-prospectivo de 18 pacientes hospitalizados para el estudio de una FOD clásica en los que se estableció el diagnóstico de linfoma maligno durante los años 2000 al 2005. Resultados: Más de la mitad de los casos (55%) se encontraba en estadio IV. Se detectó perdida de peso en 13 pacientes (72%) y adenopatías periféricas en la mitad de los casos. El ultrasonido abdominal evidenció alteraciones sugestivas de linfoma maligno en el 55% de los casos. La biopsia de adenopatías periféricas o profundas estableció el diagnóstico en 8 pacientes (44%) y la de médula ósea en 6 pacientes (33%). Hubo 4 pacientes fallecidos (22%) en los que el diagnóstico solo se pudo establecer en la necropsia. Conclusiones: La mayoría de los linfomas malignos que debutaron por FOD se encontraba en estadio avanzado. La perdida de peso y las adenopatías periféricas fueron las manifestaciones clínicas más frecuentes. El ultrasonido abdominal, la biopsia de adenopatías y la de médula ósea fueron los procederes de mayor utilidad diagnóstica. Abstract in english Objective: The main cause of fever of unknown origin (FUO) in the diagnostic category of neoplasms are malignant lymphomas. This study was done to describe the clinical features and the investigation results which diagnostic contribution. Method: Between 2000 and 2005 a prospective and descriptive s [...] tudy was conducted in 18 patients hospitalized for studying a classical FUO who were diagnosed as having a malignant lymphoma. Results: More than half of all patients (55%) were in stage IV. The weight loss and the peripheral lymphadenopathy were found in 13 (72%) and 9 patients (50%), respectively. Abdominal ultrasonography had a diagnostic contribution in 55% of the patients. The malignant lymphoma diagnostic was made by peripheral or deep lymphadenopathy biopsy in 8 patients (44%). The bone marrow biopsy established diagnostic in 6 patients (33%). In four patients (22%) the diagnosis was made at the autopsy. Conclusions: Most of patients with malignant lymphomas presenting as FUO had an advanced disease. The weight loss and the peripheral lymphadenopathy were the most frequent clinical features. Abdominal ultrasonography, lymphadenopathy biopsy and bone marrow biopsy were the procedures with more diagnostic utility.

V., Roca Campañá; H., Rodríguez Silva.

2007-11-01

295

Nódulos pulmonares fluctuantes como forma de presentación de un linfoma MALT / Fluctuant pulmonary nodules as presentation of a MALT lymphoma  

Scientific Electronic Library Online (English)

Full Text Available El linfoma tipo MALT, o del tejido asociado a mucosas, es un linfoma no Hodking de bajo grado de malignidad, cuya localización más frecuente es el tracto gastrointestinal, principalmente el estómago; su presentación primaria pulmonar es infrecuente, localización en la que puede presentar distintas i [...] mágenes radiológicas. Presentamos el caso de una mujer de 61 años, con antecedentes personales de vitíligo, ulcus gástrico, cirrosis hepática por virus de la hepatitis C, que ingresó por un cuadro de disnea súbita, dolor en punta de costado derecho de carácter pleurítico y fiebre de 38,5º C, cuya radiografía de tórax y TAC torácico mostraban imágenes nodulares en "suelta de globos", que afectaban a distintos lóbulos pulmonares. En la citología por PAAF se confirma su naturaleza maligna. En controles radiológicos posteriores se observó una desaparición completa de los nódulos y reaparición en localizaciones pulmonares distintas en cada recidiva a lo largo de tres años de evolución. La presentación en forma de nódulos pulmonares fluctuantes es excepcional en un linfoma tipo MALT. Se ha descrito una mayor incidencia de infección por virus de la hepatitis C y neoplasias adicionales. La existencia de una hepatitis crónica por virus C, procesos inflamatorios crónicos locales, así como enfermedades de base autoinmune, podrían considerarse como factores que pueden contribuir a desencadenar un linfoma tipo MALT. Abstract in english Mucosa associated lymphoid tissue (MALT) lymphomas are a group of non- Hodgkin’s lymphomas of low malignancy degree. The most frequent location is the gastrointestinal tract. Its primary pulmonary presentation is unusual and heterogeneous from point of view radiological. Woman 61 years old with ante [...] cedents of vitiligo, gastric ulcus, cirrhosis by VHC, that go into the hospital by sudden disnea, thoracic paint with pleural characterises and fever of 38.5º C, Her thorax radiography and thoracic TAC showed nodes that affect to different pulmonary lobes. The cytology by PAAF confirms their malignant nature. In subsequent radiological controls it was notice the nodels took away completely and returns in different pulmonary place in each recurrence. The presentation like fluctuant pulmonary nodes is exceptional in a MALT lymphoma. It was described a higher incidence of VHC infection and tumour. The evidence of chronic hepatitis by virus C disease, and local chronic inflammatory process as well as autoimmune disorders may be considerate like a factor that contribute to MALT lymphoma.

R., Dolz Aspas; C., Toyas Miazza; F., Ruiz Ruiz; J. L., Morales Rull; J. I., Pérez Calvo.

2003-11-01

296

Basic studies on intravascular low-intensity laser therapy  

Science.gov (United States)

Intravascular low intensity laser therapy (ILILT) was originally put forward in USA in 1982, but popularized in Russia in 1980s and in China in 1990s, respectively. A randomized placebo-controlled study has shown ILILT clinical efficacy in patients suffering from rheumatoid arthritis. As Chinese therapeutic applications of ILILT were the most widely in the world, its basic research, such as intracellular signal transduction research, blood research in vitro, animal blood research in vivo, human blood research in vivo and traditional Chinese medicine research, was also very progressive in China. Its basic studies will be reviewed in terms of the biological information model of photobiomodulation in this paper. ILILT might work in view of its basic studies, but the further randomized placebo-controlled trial and the further safety research should be done.

Liu, Timon Cheng-Yi; Duan, Rui; Wang, Shuang-Xi; Liu, Jiang; Cui, Li-Ping; Jin, Hua; Liu, Song-Hao

2006-09-01

297

Evaluation of Disseminated Intravascular Coagulation in the Craniocerebral Traumas  

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Full Text Available Traumatic injury is one of the most important cause of disseminated intravascular coagulation (DIC. It occurs because of blood loss and hemodilution due to fluid resuscitation. The incidence of trauma associated DIC is mainly higher in the craniocerebral traumas. Even though craniocerebral trauma related DIC is well defined, the pathophysiology has been poorly characterized in the literature. Due to the fact that brain tissue is highly significant for procoagulant molecules, craniocerebral traumas are closely related to DIC. In the current study, 30 patients admitted to emergency room have been considered on the first and fifth day of admission to the hospital for the coagulation tests to evaluate DIC in both two groups. [Cukurova Med J 2014; 39(3.000: 488-495

Faruk Altinel

2014-06-01

298

Disseminated intravascular coagulation in patients with solid tumors.  

Science.gov (United States)

Disseminated intravascular coagulation (DIC) is an occasional complication of solid tumors, usually identified at the time of presentation because of excessive bleeding, thromboembolic complications, or abnormal laboratory test results. The latter include an unexplained low platelet count, a low fibrinogen level, an elevated D-dimer level, and a prolonged prothrombin time. Prompt diagnosis and treatment of the underlying malignancy can result in resolution of the DIC. Further, if the tumor is responsive to chemotherapy, a reasonable median survival can also result. Excessive bleeding at presentation can be managed with platelet transfusions, cryoprecipitate, and fresh frozen plasma. Thromboembolic complications can be managed with continuous intravenous heparin and supportive platelet transfusions; cryoprecipitate can be used whenever necessary to support platelet and fibrinogen levels. On occasion, when excessive bleeding and venous thromboembolism occur together, placement of a vena cava filter is required, along with the administration of platelets and cryoprecipitate. PMID:25683828

Feinstein, Donald I

2015-02-01

299

Brachytherapy optimal planning with application to intravascular radiation therapy  

DEFF Research Database (Denmark)

We have been studying brachytherapy planning with the objective of manimizing the maximum deviation of the delivered dose from prescribed dose bounds for treatment volumes. A general framework for optimal treatment planning is presented and the minmax optimization is formulated as a linear program. Dose rate calculations are based on the sosimetry formulation of the American Association of Physicists in Medicine, Task Group 43. We apply the technique to optimal planning for intravascular brachytherapy of intimal hyperplasia using ultrasound data and 192Ir seeds. The planning includes determination of an optimal dwell-time sequence for a train of seeds that deliver ratiation while stepping through the vessel lesion. The results illustrate the advantage of this strategy over the common approach of delivering radiation by positioning a single train of seeds along the whole lesion.

Sadegh, Payman; Mourtada, Firas A.

1999-01-01

300

Intravascular ultrasound: a guide for management of complications during intervention?  

Science.gov (United States)

Within a few years, intravascular ultrasound (IVUS) has emerged from a research tool into an intrinsic part of modern invasive cardiology, mainly because histology can be obtained 'in-vivo'. For the first time in invasive cardiology it is possible to base decisions not only on lumenograms but also on vessel wall assessment. IVUS can be used as both a diagnostic tool and for intervention purposes. Its diagnostic strength lies in its ability to monitor compensatory coronary artery enlargement as a response to arteriosclerosis, to reveal occult left main stem disease, and angiographically 'silent' arteriosclerosis. As regards intervention, IVUS aids in optimal device selection, i.e. whether to use rotablators in calcified lesions or atherectomy devices in large plaques. The effects of PTCA on vessel wall morphology can be studied in great detail and the effect on luminal gain assessed almost on-line. Several groups have shown that the residual plaque area, even after angiographically successful PTCA, is about 60%. A significant reduction in this percentage may influence long-term outcome after PTCA. Luminal areas that are minimal after PTCA seem to indicate restenosis, while morphological appearance on its own seems to be less predictive. One answer to the shortcomings of standard PTCA are coronary artery stents. Intravascular monitoring of stent expansion led to the deployment of high-pressure stents with a significant increase in post-procedural luminal diameters, and finally the ability to withhold anticoagulation in patients with optimal stent deployment. Furthermore, integrated devices, such as balloons on IVUS catheters, steerable catheters, integrated flow measurements, pressure transducers, and, hopefully, tissue characterization, will further enhance the usefulness of IVUS. PMID:8869025

Görge, G; Ge, J; Haude, M; Baumgart, D; Caspari, G; Leischik, R; Liu, F; Erbel, R

1995-11-01

301

The use of recombinant factor VIIa in a pediatric septic shock patient with disseminated intravascular coagulation  

Directory of Open Access Journals (Sweden)

Full Text Available This is a report on a pediatric patient with septic shock and disseminated intravascular coagulation, who developed life-threatening bleeding which was successfully treated with recombinant factor VIIa.

Ronaldo Arkader

2008-03-01

302

The use of recombinant factor VIIa in a pediatric septic shock patient with disseminated intravascular coagulation  

OpenAIRE

This is a report on a pediatric patient with septic shock and disseminated intravascular coagulation, who developed life-threatening bleeding which was successfully treated with recombinant factor VIIa.

Ronaldo Arkader; Eduardo Juan Troster; Albert Bousso

2008-01-01

303

Severe disseminated intravascular coagulation associated with massive ventricular mural thrombus following acute myocardial infarction.  

OpenAIRE

We describe three patients who developed severe disseminated intravascular coagulation associated with large ventricular mural thrombi shortly after presenting with acute myocardial infarction. To our knowledge this association has not been reported before.

Solomon, S. A.; Cotton, D. W.; Preston, F. E.; Ramsay, L. E.

1988-01-01

304

Intravascular radiation for restenosis prevention: could it be the holy grail?  

Energy Technology Data Exchange (ETDEWEB)

This brief editorial discusses the use of intravascular radiation in preventing restenosis after angioplasty in coronary interventions. Results in porcine coronary arteries and clinical applications are briefly reported. (UK).

King, S.B. [Emory Univ., Atlanta, GA (United States)

1996-08-01

305

Intravascular radiation for restenosis prevention: could it be the holy grail?  

International Nuclear Information System (INIS)

This brief editorial discusses the use of intravascular radiation in preventing restenosis after angioplasty in coronary interventions. Results in porcine coronary arteries and clinical applications are briefly reported. (UK)

306

Intravascular Optical-Resolution Photoacoustic Tomography with a 1.1 mm Diameter Catheter  

OpenAIRE

Photoacoustic imaging is an emerging technology that can provide anatomic, functional, and molecular information about biological tissue. Intravascular spectroscopic and molecular photoacoustic imaging can potentially improve the identification of atherosclerotic plaque composition, the detection of inflammation, and ultimately the risk stratification of atherosclerosis. In this study, a first-of-its-kind intravascular optical-resolution photoacoustic tomography (OR-PAT) system with a 1.1 mm ...

Bai, Xiaosong; Gong, Xiaojing; Hau, William; Lin, Riqiang; Zheng, Jiaxiang; Liu, Chengbo; Zeng, Chengzhi; Zou, Xin; Zheng, Hairong; Song, Liang

2014-01-01

307

Development of a catheter for combined intravascular ultrasound and photoacoustic imaging  

OpenAIRE

Atherosclerosis is characterized by formation and development of the plaques in the inner layer of the vessel wall. To detect and characterize atherosclerotic plaques, we previously introduced the combined intravascular ultrasound (IVUS) and intravascular photoacoustic (IVPA) imaging capable of assessing plaque morphology and composition. The utility of IVUS?IVPA imaging has been demonstrated by imaging tissue-mimicking phantoms and ex vivo arterial samples using laboratory prototype of the...

Karpiouk, Andrei B.; Wang, Bo; Emelianov, Stanislav Y.

2010-01-01

308

Advanced Gastric Cancer Associated with Disseminated Intravascular Coagulation Successfully Treated with 5-fluorouracil and Oxaliplatin  

OpenAIRE

Gastric cancer patients with acute disseminated intravascular coagulation experiences a rare but severe complication resulting in a dismal prognosis. We report a case of advanced gastric cancer complicated with disseminated intravascular coagulation with intractable tumor bleeding which was successfully treated with chemotherapy consisting of 5-fluorouracil and oxaliplatin. The patient was a 63-year-old man who complained of abdominal pain, melena, and dyspnea on 24 November 2010. We diagnose...

Lee, Dong Seok; Yoo, Seung Jin; Oh, Ho Suk; Kim, Eun Jung; Oh, Kwang Hoon; Lee, Sang Jin; Park, Jong Kyu; Ahn, Yong Chel; Eom, Dae-woon; Ahn, Heui June

2013-01-01

309

Recent acquisitions in the pathophysiology, diagnosis and treatment of disseminated intravascular coagulation  

OpenAIRE

Abstract Disseminated intravascular coagulation (DIC) is a disorder characterized by both acute generalized, widespread activation of coagulation, which results in thrombotic complications due to the intravascular formation of fibrin, and diffuse hemorrhages, due to the consumption of platelets and coagulation factors. Systemic activation of coagulation may occur in a variety of disorders, including sepsis, severe infections, malignancies, obstetric or vascular disorders, and severe toxic or ...

Lippi Giuseppe; Franchini Massimo; Manzato Franco

2006-01-01

310

Lack of correlation between delayed traumatic intracerebral haematoma and disseminated intravascular coagulation.  

OpenAIRE

The relationship between delayed traumatic intracerebral haematoma and disseminated intravascular coagulation was investigated. Eighteen patients with delayed traumatic intracerebral haematoma were selected as the study subjects from 268 consecutive patients with head trauma and compared with another two groups of patients with closed head injury (20 cases) and with multiple injuries (24 cases). All cases had six laboratory studies for disseminated intravascular coagulation for 7 days. The re...

Sawada, Y.; Sadamitsu, D.; Sakamoto, T.; Ikemura, K.; Yoshioka, T.; Sugimoto, T.

1984-01-01

311

A basic study of electrical impedance spectroscopy for intravascular diagnosis and therapy monitoring of atherosclerosis  

OpenAIRE

The thesis reports about the feasibility of electrical impedance spectroscopy with microsystems for the intravascular diagnosis of atherosclerosis. Based on a basic investigation on the cellular level, it describes how the impedance of vessel walls on the microscale is determined and how the cellular alteration related with atherosclerosis affects the measured impedance. For an intravascular impedance characterization of vessels, it shows the development of a balloon impedance catheter (BIC) ...

Cho, Sungbo

2008-01-01

312

estatinas afectan la viabilidad de líneas celulares de leucemia y linfoma humanas in vitro  

Scientific Electronic Library Online (English)

Full Text Available SciELO Venezuela | Language: Spanish Abstract in spanish Se ha propuesto que las estatinas inducen apoptosis sobre células tumorales. Para probar dicha hipótesis, se analizó el efecto de las estatinas atorvastatina, fluvastatina, lovastatina, mevastatina, pravastatina y simvastatina en el rango de concentraciones de 1 pM hasta 100 ?M, sobre la viabilidad [...] de las líneas celulares humanas Jurkat E6.1, Jurkat D1.1 (Linfoma T) , Daudi (Linfoma B), U937 (leucemia monocítica) y HL-60 (leucemia promielomonocítica) in vitro en cultivos de 48 horas, analizados por la técnica de hidrolización del compuesto bromuro de 3-(4,5-dimetiltiazol-2-il)-2,5-difenilltetrazolio (MTT). Lovastatina y mevastatina son los más potentes inductores de muerte celular independientemente del tipo celular (Ic 50 entre 12 y 50 ?M). Para las otras estatinas se observan diferencias en el Ic50 según la línea celular atorvastatina (38,1 y 48,6 ?M Jurkats, 55,3 ?M Daudi y 100 ?M para las otras líneas), pravastatina (25 ?M HL-60, 55,6 y 60,7 ?M Jurkats y ? 100 ?M Daudi y U937), simvastatina (25,1 ?M Jurkat D1.1, 50,2 ?M Jurkat E6.1, 45,2 ?M Daudi y 51,3 ?M HL-60, y > 100 ?M U937) y para fluvastatina en todos los casos > 100 ?M. La disminución de la viabilidad celular se revierte completamente cuando las células son incubadas con 10 ?M mevalonato. Se concluye que la lovastatina y mevastatina son las más potentes inductoras de muerte seguida por atorvastatina, pravastatina y simvastatina cuyo efecto depende del tipo de línea celular y la fluvastatina no tiene efectos importantes en la viabilidad de las líneas celulares estudiadas. Abstract in english Statins have been proposed to induce apoptosis of tumor cells. In order to test this hypothesis, the effect of atorvastatin, fluvastatin, lovastatin, mevastatin, pravastatin, simvastatin on cell viability was assessed by in vitro culture for 48 hr, at concentrations ranging from 1 pM to 100 ?M on hu [...] man cell lines Jurkat E6.1, Jurkat D1.1 (T cell lymphoma), Daudi (B cell lymphoma), U937 (monocitic leukemia) and HL-60 (pro mielomonocitic leukemia) and analyzed the oxidation of (3-(4.5-Dimethylthiazol-2-yl)-2.5- diphenyltetrazolium bromide (MTT). Lovastatin and mevastatin are the most potent inductors of cell death independently of the cell type (Ic 50 between 12 and 50 ?M). Differences in the Ic50 are observed depending on the cell line: atorvastatina (38.1 and 48.6 ?M Jurkats, 55.3 ?M Daudi y 100 ?M for the others lines), pravastatin (25 ?M HL-60, 55.6 y 60.7 ?M Jurkats and ? 100 ?M Daudi and U937), simvastatin (25.1 ?M Jurkat D1.1, 50.2 ?M Jurkat E6.1, 45.2 ?M Daudi and 51,3 ?M HL-60, and > 100 ?M U937) and for fluvastatin > 100 ?M in all cases. The decrease in cell viability is reverted completely when the cells were incubated with 10 ?M mevalonate. It is concluded that lovastatin and mevastatin are the most potent inductors of cell death followed by atorvastatin, pravastatin and simvastatin whose effect depends upon the cell type and fluvastatin does not have any important effects on cell viability on the cell lines studied.

Mery, Guerrero; Camilo, Di Giulio; Juan Bautista, De Sanctis.

2010-06-01

313

Enfermedad de Von Willebrand adquirida en un linfoma linfoplasmocitario/Macroglobulinemia de Waldenström: reporte de caso  

Scientific Electronic Library Online (English)

Full Text Available Resumo A doença de Von Willebrand adquirida é pouco freqüente e surge no contexto de doenças auto-imunes, síndromes linfoproliferativos e mieloproliferativos. Descrevemos o caso de uma paciente portadora de linfoma linfoplasmocitario com doença de Waldenström, que apresentava uma síndrome hemorragíp [...] ara e alterações da crase sanguínea da via intrínseca. As gamapatias monoclonais como a macroglobulinemia de Waldenström podem apresentar-se com dosificação variável da IgM que neste caso era 11 g/dl. O quadro clínico pode ser proteiforme afetando vários sistemas, apresentado nesta paciente uma complicação por adsorção tumoral: a doença de Von Willebrand adquirida. Para o tratamento da doença de base foi indicada quimioterapia com talidomida, ciclofosfamida e dexametasona que levou a uma evolução favorável com remissão da síndrome hemorragípara com tendência à normalização da crase e dos valores de glóbulos e plaquetas depois de seis séries de tratamento. Outras medidas terapêuticas orientadas à reversão da coagulopatia como a plasmaferese possuem ação transitória e não estão isentas de risco e são sugeridas quando há hiperviscosidade aguda com risco vital. A avaliação multidisciplinar da paciente favoreceu o diagnóstico e o tratamento. Abstract in spanish La enfermedad de Von Willebrand adquirida es una situación infrecuente que se genera en el contexto de enfermedades autoinmunes, síndromes linfoproliferativos y mieloproliferativos. Se presenta el caso clínico de una paciente portadora de un linfoma linfoplasmocitario con enfermedad de Waldenström, [...] presentándose con un síndrome hemorragíparo y alteraciones de la crasis sanguínea a nivel de la vía intrínseca. Las gammapatías monoclonales como la macroglobulinemia de Waldenström suelen presentarse con dosificaciones de IgM variables, siendo, en el caso que se describe, 11 g/dl. La clínica puede ser muy proteiforme, afectando varios sistemas, presentando en este caso una complicación por adsorción tumoral: la enfermedad de Von Willebrand adquirida. Se indicó tratamiento quimioterápico en base a talidomida, ciclofosfamida y dexametasona para la enfermedad de base, evolucionando favorablemente, remitiendo el síndrome hemorragíparo con tendencia a la normalización de la crasis, de los valores globulares y plaquetarios en forma mantenida luego de seis series de tratamiento. Otras medidas terapéuticas dirigidas a revertir la coagulopatía, como la plasmaféresis, poseen acción transitoria, no estando exentas de riesgo, y se plantean ante hiperviscosidad aguda manifiesta con riesgo vital. La valoración de la paciente en forma interdisciplinaria permitió el mejor acercamiento diagnóstico y terapéutico. Abstract in english Summary Acquired Von Willebrand disease is an unusual situation arising within the context of self-immune diseases, lymphoproliferative and mieloproliferative disorders. The study presents the clinical case of a patient carrier of a lymphoplasmocitary lymphoma with Waldenström's disease which presen [...] ted with a hemorrhagic syndrome and alterations of the blood crasis in the intrinsic way. Monoclonal gammopathies such as Waldenström's macroglobulinemia usually appear with varied IgM dosifications, being it 11 g/dl in the case described. Clinical symptoms may be very proteiform, affecting several systems, and in this case it presented complications resulting from tumor adsorption: acquired Von Willebrand disease. Chemotherapy with thalidomide, cyclophosphamide and dexamethasone was indicated for the base disease and there was favourable evolution, the hemorrhagic syndrome remitted and there was a tendency to crasis normalization, the same as globular and platelets values ongoing normalization after six series of treatment. Other therapeutic measures aiming to reverse coagulopathy, such as plasmapheresis, are short-acting, and they are not exempt from risks, and they are considered as options upon obvious acute hyperviscosity with a risk of life. Multidisc

Isabel, Moro; Carolina, Oliver; Mariana, Stevenazzi; Cecilia, Guillermo; Silvia, Pierri; Jorge, Decaro.

2010-12-01

314

Linfoma MALT de parótida, presentación de un caso clínico y revisión del tema / Parotid MALT lymphoma, presentation of a clinical case and review of subject  

Scientific Electronic Library Online (English)

Full Text Available Los linfomas de las glándulas salivales son una entidad poco frecuente, estimándose una incidencia del 5%. La localización más habitual es la glándula parótida, seguida de la submaxilary la sublingual. La mayoría de los linfomas parotídeos son linfomas no Hodgkin (LNH) y se consideran derivados del [...] tejido linfoide asociado a mucosas (MALT). Infrecuentemente se han reportado estos casos y suelen ser subdiagnosticados por su presentación relativamente benigna, comportándose de forma localizada, de lento crecimiento, con varios años de evolución. Presentamos un caso clínico de linfoma tipo MALT de parótida de acuerdo a las características clínicas, histológicas e inmunohistoquímicas de este tumor. Además una revisión de la literatura de este caso. Abstract in english Lymphomas of the salivary glands are a rare entity, with an estimated incidence of 5%. The most frequent location is parotid gland, followed by the submandibular and sublingual. The majority of parotid lymphomas are non-Hodgkin's lymphoma NHL and are considered derived from mucosa-associated lymphoi [...] d tissue (MALT). Infrequently these cases have been reported and are often underdiagnosed for their presentation is relatively benign, localized behaving, slow growing, with several years of evolution. We report a case of parotid MALT lymphoma according to the clinical, histological and immunohistochemical characteristics of this tumor. In addition, a literature review of this case.

Francisca, Fernández A; Carlos, Espinoza N; Víctor, Mercado M; Humberto, Vallejos A.

2012-04-01

315

Tratamento do linfoma de Hodgkin após falha do transplante autólogo / Treatment of Hodgkin's lymphoma after failure of autologous stem cell transplant  

Scientific Electronic Library Online (English)

Full Text Available O linfoma de Hodgkin (LH) é uma neoplasia do tecido linfóide de excelente prognóstico, porém, aproximadamente 15% dos pacientes em estádios precoces e 35% dos em estádios avançados progridem após o tratamento inicial. O transplante autólogo de medula óssea ou de células-tronco periféricas (ATMO) é o [...] tratamento de escolha nesses casos. Nosso estudo tem como objetivo avaliar o tipo de tratamento utilizado, a taxa de resposta e a sobrevida de pacientes recidivados ou refratários ao ATMO. De 38 pacientes com LH submetidos a ATMO entre abril de 1996 e novembro de 2005, foram avaliados 17 que apresentaram recidiva/refratariedade ao ATMO. Nesses casos, o tratamento de resgate foi individualizado, a depender das condições clínicas de cada um, sendo constituído usualmente de drogas citotóxicas não utilizadas previamente. Após o ATMO, dez (59%) dos 17 pacientes obtiveram remissão completa, um (6%) remissão parcial e seis (35%) foram refratários. Em 14 dos 17 pacientes foi instituída quimioterapia de resgate com diversos esquemas no momento da recidiva/refratariedade após ATMO; um paciente foi tratado com radioterapia exclusiva e dois foram a óbito antes de qualquer terapia. Observamos uma taxa de resposta global de 57,4% (IC95%: 23,2 - 90,7%). A mediana da sobrevida livre de progressão foi de 19 meses e a mediana de sobrevida global foi de 32 meses. Apesar do LH recidivado/refratário ao ATMO não ser curável com os quimioterápicos atualmente disponíveis, os pacientes apresentaram longa sobrevida, com freqüentes exacerbações da doença. Abstract in english Hodgkin's lymphoma (HL) is a lymphoid malignancy with excellent prognosis, however nearly 15% of the patients in early stages and 35% in advanced stages have progressive disease after initial treatment. Autologous bone marrow or hematopoietic stem cell transplantation (ABMT) are the treatments of ch [...] oice in these cases. This report presents the therapeutic approach and the outcome of HL patients who experience relapse after or are refractory to ABMT. Of 38 patients with LH who underwent ABMT between April 1996 and November 2005, 17 presented with relapsed/refractory disease and were included in this analysis. In these cases, the choice of rescue therapy varied upon the clinical conditions of each patient and was based on previously unused chemotherapy agents. After ABMT, 10 (59%) of the 17 patients were in complete remission, one (6%) in partial remission and six (35%) were refractory. Fourteen of the 17 patients received different schemes of rescue therapy at the time of ABMT failure, one patient was treated exclusively with radiotherapy and two died before any treatment. We observed an overall response rate of 57.4% (95% CI: 23.2 - 90.7%). The median progression-free survival was 19 months and the median overall survival was 32 months. Despite ABTM, relapsed/refractory LH can not be cured with currently available chemotherapeutic agents, the patients had long survival times with frequent exacerbations of the diseas.

Fernanda M., Santos; Luís F., Pracchia; Camila G. C., Linardi; Valeria, Buccheri.

2008-08-01

316

Tratamento do linfoma de Hodgkin após falha do transplante autólogo Treatment of Hodgkin's lymphoma after failure of autologous stem cell transplant  

Directory of Open Access Journals (Sweden)

Full Text Available O linfoma de Hodgkin (LH é uma neoplasia do tecido linfóide de excelente prognóstico, porém, aproximadamente 15% dos pacientes em estádios precoces e 35% dos em estádios avançados progridem após o tratamento inicial. O transplante autólogo de medula óssea ou de células-tronco periféricas (ATMO é o tratamento de escolha nesses casos. Nosso estudo tem como objetivo avaliar o tipo de tratamento utilizado, a taxa de resposta e a sobrevida de pacientes recidivados ou refratários ao ATMO. De 38 pacientes com LH submetidos a ATMO entre abril de 1996 e novembro de 2005, foram avaliados 17 que apresentaram recidiva/refratariedade ao ATMO. Nesses casos, o tratamento de resgate foi individualizado, a depender das condições clínicas de cada um, sendo constituído usualmente de drogas citotóxicas não utilizadas previamente. Após o ATMO, dez (59% dos 17 pacientes obtiveram remissão completa, um (6% remissão parcial e seis (35% foram refratários. Em 14 dos 17 pacientes foi instituída quimioterapia de resgate com diversos esquemas no momento da recidiva/refratariedade após ATMO; um paciente foi tratado com radioterapia exclusiva e dois foram a óbito antes de qualquer terapia. Observamos uma taxa de resposta global de 57,4% (IC95%: 23,2 - 90,7%. A mediana da sobrevida livre de progressão foi de 19 meses e a mediana de sobrevida global foi de 32 meses. Apesar do LH recidivado/refratário ao ATMO não ser curável com os quimioterápicos atualmente disponíveis, os pacientes apresentaram longa sobrevida, com freqüentes exacerbações da doença.Hodgkin's lymphoma (HL is a lymphoid malignancy with excellent prognosis, however nearly 15% of the patients in early stages and 35% in advanced stages have progressive disease after initial treatment. Autologous bone marrow or hematopoietic stem cell transplantation (ABMT are the treatments of choice in these cases. This report presents the therapeutic approach and the outcome of HL patients who experience relapse after or are refractory to ABMT. Of 38 patients with LH who underwent ABMT between April 1996 and November 2005, 17 presented with relapsed/refractory disease and were included in this analysis. In these cases, the choice of rescue therapy varied upon the clinical conditions of each patient and was based on previously unused chemotherapy agents. After ABMT, 10 (59% of the 17 patients were in complete remission, one (6% in partial remission and six (35% were refractory. Fourteen of the 17 patients received different schemes of rescue therapy at the time of ABMT failure, one patient was treated exclusively with radiotherapy and two died before any treatment. We observed an overall response rate of 57.4% (95% CI: 23.2 - 90.7%. The median progression-free survival was 19 months and the median overall survival was 32 months. Despite ABTM, relapsed/refractory LH can not be cured with currently available chemotherapeutic agents, the patients had long survival times with frequent exacerbations of the diseas.

Fernanda M. Santos

2008-08-01

317

Linfoma cutáneo de células B grande de las piernas: presentación de un caso / Large B-cell skin lymphoma of the legs: a case presentation  

Scientific Electronic Library Online (English)

Full Text Available Introducción: los linfomas cutáneos primarios de células B se definen como una proliferación neoplásica de células B que se originan en la piel. El linfoma de células B grande de las piernas, es un linfoma agresivo con un predominio de células B grande que se presenta en las extremidades inferiores. [...] Existen múltiples clasificaciones con diferentes nomenclaturas; debido a la accesibilidad de la piel resulta relativamente sencillo tomar una biopsia, con lo que se obtienen muestras de lesiones precoces y más difíciles de diagnosticar. Objetivo: reportar un paciente con linfoma cutáneo de células B grande de la pierna. Caso Clínico: paciente masculino de 72 años, blanco, con presencia de múltiples tumores en las piernas, de varios meses de evolución, y se le diagnostica como un linfoma cutáneo de células B grande de las piernas. Conclusiones: el linfoma cutáneo de células B grande de la pierna es una enfermedad poco frecuente, que representan un subtipo clínico e histológico diferente de linfomas extranodales, no doloroso, de evolución buena, y buen pronóstico, cuya clasificación y origen celular es controvertido. El principal criterio de diagnóstico es la clínica y la histopatología. El tratamiento conservador se instala para esta enfermedad, se obtienen buenos resultados con la poliquimioterapia, además de otras alternativas como la terapia con anticuerpos monoclonales. Abstract in english Introduction: B-cell primary skin lymphomas are defined as neoplastic proliferation of B-cell originated on the skin. Large B-cell lymphoma of the leg is an aggressive lymphoma with predominance of large B-cell that appear in lower limbs. There are multiple classifications with different varieties. [...] Due to the accessibility of the skin, it is very easy to perform a biopsy and obtain samples of early lesions that are difficult to diagnose. Objective: to report a case of large B-cell skin lymphoma of the leg. Clinical Case: a 72 year-old, white man, came to the hospital complaining of several tumors on the legs that had appeared many months before. He was diagnosed a large B-cell skin lymphoma of the leg. Conclusions: large B-cell skin lymphoma of the leg is an infrequent disease that represents a different clinical and histological subtype of extranodular lymphoma. It is no painful with good recovery and prognosis but its cellular classification and origin is controversial. Diagnosis is based on clinical and histopathologic examination. This disease is treated with combination of chemotherapy and other alternatives such as monoclonal antibodies therapy.

Idalmis, Campollo Rodríguez; Mauricio, Socarrás Laborda; Patricia Alejandra, Castro Sánchez.

1037-10-01

318

Linfoma primario del sistema nervioso central: serie de casos / Primary lymphoma of the central nervous system: case series  

Scientific Electronic Library Online (English)

Full Text Available SciELO Colombia | Language: Spanish Abstract in spanish INTRODUCCIÓN: el linfoma primario del sistema nervioso central (LPSNC) corresponde a una causa de importante mortalidad dentro de los tumores primarios del sistema nervioso central, además existen pocos datos epidemiológicos actualmente, razón por la cual se decide hacer un reporte de casos en el gr [...] upo de neuropatología de la Universidad de Antioquia. OBJETIVO: describir el comportamiento de esta patología en un grupo de pacientes. MATERIALES Y MéTODOS: se revisaros los estudios patológicos e historias clínicas de 12 pacientes con diagnóstico de LPSNC en el servicio de neuropatología de la Universidad de Antioquia 2004 el 2011. RESUTADOS: se encontraron 12 pacientes que cumplían el criterio de inclusión. De estos pacientes el 61.5% fueron hombres y el 38.5% mujeres. La edad promedio al momento del diagnóstico fue de 42.6 años (1- 77 años). El Linfoma B no hodking de células gigantes con patrón difuso fue el tumor más frecuente con un 83.3 %, 8.35% corresponde a linfoma de células T, 8.35% a Linfoma de Burkitt; 33.3 % corresponden a pacientes inmunode-ficientes. CONCLUSIóN: en esta serie de pacientes con linfoma del sistema nervioso central se encontraron características clínicas similares a las encontradas en la literatura, quizás el único hallazgo disímil fue la mayor cantidad de pacientes sin aparente alteración en el sistema inmune. Abstract in english INTRODUCTION: primary lymphoma of the central nervous system (PCNSL) is a major cause of mortality in primary tumors of the central nervous system, plus there are only a few epidemiological data today, these are the reasons why it was decided to make a report of cases in the group of neuropathology [...] at the University of Antioquia. OBJETIVES: to describe the behavior of this disease in group of patients. MATERIALS AND METHODS: we reviewed the pathological studies and clinical records of 12 patients diagnosed with PCNSL in the service of neuropathology at the University of Antioquia from the years of 2004 to 2011. RESULTS: there were 12 patients who met the inclusion criteria. Of these patients, 61.5% were male and 38.5% women. The average age at diagnosis was 42.6 years (1 - 77 years). The giant cell, diffuse pattern B non-Hodgkin lymphoma was the most frequent tumor with 83.3%,T- cell lymphoma with 8.35%, Burkitt lymphoma 8.35%; 33.3% of the patients were immunodeficient. CONCLUSION: in this series of patients with central nervous system lymphoma similar clinical characteristics were found to those in the medical literature, perhaps the only different finding was a higher rate of patients without an apparent alteration in the immune system.

Jorge Andrés, Jiménez Arango; Salomé, Martínez López; Juan Pablo, Gómez Escobar; Carlos Santiago, Uribe Uribe; Juan Carlos, Arango Viana.

2012-03-01

319

Linfoma não-Hodgkin em crianças com imunodeficiência: relato de cinco casos Non-Hodgkin's lymphoma in children with immunodeficiency: report of five cases  

Directory of Open Access Journals (Sweden)

Full Text Available Neste estudo é relatado o quadro clínico de cinco crianças com linfoma não-Hodgkin secundário a imunodeficiência ou imunossupressão: três portadoras do vírus da imunodeficiência humana, uma com imunodeficiência primária e uma após transplante hepático. De acordo com a classificação atual, os tipos histológicos foram: linfoma linfoblástico de células B precursoras (2, linfoma cutâneo de grandes células anaplásico (1, linfoma de células B periféricas, sugestivo de Burkitt (1, e linfoma linfoblástico de células T precursoras (1. Todos os pacientes foram submetidos a quimioterapia, sendo que dois estão em remissão clínica, dois morreram e um continua em tratamento. Após a introdução da terapia anti-retroviral combinada e o aumento dos transplantes de órgãos sólidos ocorre maior risco de neoplasia nesses pacientes. Desse modo, é importante o seguimento desses pacientes para determinar os fatores de risco para o desenvolvimento de neoplasias e definir adequada estratégia de tratamento.The outcomes of five children with non-Hodgkin's lymphomas associated with immunodeficiency or immunosuppression is reported: three children with HIV, one with primary immunodeficiency and one after liver transplantation. According to the REAL classification, two patients had precursor B-lymphoblastic lymphomas, one had an anaplastic large cell lymphoma, one had a peripheral B-cell neoplasm suggestive of Burkitt's lymphoma, and one had precursor T-lymphoblastic lymphoma. All patients received chemotherapy. Two are in complete remission, two died and one remains under treatment. There has been an increasing awareness of the risk of non-Hodgkin's lymphoma and lymphoproliferative disorders after active antiretroviral therapy and with the expansion of solid organ transplant programs in the pediatric setting. Thus, for these patients it is important to establish risk factors for hematological disorders and determine the optimal and safest treatment.

Maria Christina L. A. Oliveira

2008-01-01

320

Linfoma não-Hodgkin em crianças com imunodeficiência: relato de cinco casos / Non-Hodgkin's lymphoma in children with immunodeficiency: report of five cases  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Neste estudo é relatado o quadro clínico de cinco crianças com linfoma não-Hodgkin secundário a imunodeficiência ou imunossupressão: três portadoras do vírus da imunodeficiência humana, uma com imunodeficiência primária e uma após transplante hepático. De acordo com a classificação atual, os tipos h [...] istológicos foram: linfoma linfoblástico de células B precursoras (2), linfoma cutâneo de grandes células anaplásico (1), linfoma de células B periféricas, sugestivo de Burkitt (1), e linfoma linfoblástico de células T precursoras (1). Todos os pacientes foram submetidos a quimioterapia, sendo que dois estão em remissão clínica, dois morreram e um continua em tratamento. Após a introdução da terapia anti-retroviral combinada e o aumento dos transplantes de órgãos sólidos ocorre maior risco de neoplasia nesses pacientes. Desse modo, é importante o seguimento desses pacientes para determinar os fatores de risco para o desenvolvimento de neoplasias e definir adequada estratégia de tratamento. Abstract in english The outcomes of five children with non-Hodgkin's lymphomas associated with immunodeficiency or immunosuppression is reported: three children with HIV, one with primary immunodeficiency and one after liver transplantation. According to the REAL classification, two patients had precursor B-lymphoblast [...] ic lymphomas, one had an anaplastic large cell lymphoma, one had a peripheral B-cell neoplasm suggestive of Burkitt's lymphoma, and one had precursor T-lymphoblastic lymphoma. All patients received chemotherapy. Two are in complete remission, two died and one remains under treatment. There has been an increasing awareness of the risk of non-Hodgkin's lymphoma and lymphoproliferative disorders after active antiretroviral therapy and with the expansion of solid organ transplant programs in the pediatric setting. Thus, for these patients it is important to establish risk factors for hematological disorders and determine the optimal and safest treatment.

Maria Christina L. A., Oliveira; Adriana R., Rodrigues; Keyla C., Sampaio; Ana Cecília S. C., Gomes; Marcos B., Viana.

321

Linfoma primario de células T del páncreas: presentación de un caso clínico / Primary T cell lymphoma of the pancreas: clinical case report  

Scientific Electronic Library Online (English)

Full Text Available El Linfoma Primario de Páncreas es una enfermedad rara, representando el 1 % de todos los linfomas de presentación extranodal y el 0,5% de todas las masas pancreáticas. Menos de 150 casos han sido reportados en la literatura en ingles, los cuales son generalmente linfomas de células tipo B. Los linf [...] omas de celulas T, representan aproximadamente el 4% de los linfomas primarios de pancreas y la supervivencia a los 5 años es del 0%. Reportamos el caso de una mujer de 28 años de edad que se presento a la emergencia con una colangitis aguda severa y una historia insidiosa de baja de peso e icteria obstructiva. La tomografía revelo una lesión tumoral heterogénea, difusa en cabeza de páncreas asi como dilatación leve del conducto pancreático, dilatación de vía biliar intra y extra-hepatica, no adenopatías retroperitoneales y sin infiltración hepática ni esplénica. Se realizo una autopsia dirigida y los estudios histopatologicos confirmaron un linfoma no Hodgkin de células T, CD3 + CD20-. Abstract in english Primary pancreatic lymphomas (PPL) are rare tumors, comprising 1% of extra-nodal lymphomas and 0.5% of all pancreatic masses. Fewer than 150 cases have been reported worldwide, which most commonly are large B cell lymphomas. T cell lymphomas comprise 4% of all PPL and present a 5-year survival rate [...] of 0%. We report the case of a 28 year-old peruvian woman who presented with a fatal acute cholangitis and a history of insidious weight loss and obstructive jaundice. The CT scan revaled a diffuse heterogeneus mass in the head of the pancreas along with a mildly dilated pancreatic duct and dilated intra and extra-hepatic bile ducts, no liver, splenic involvement, or retroperitoneal adenopathies were evident. An autopsy was performed and the histopathologic investigation confirmed a T cell non-Hodgkin lymphoma, CD3+ CD20-.

Carolina I., Galarreta; Eduardo, Yepez; Cristian, Velez; Giorgio, Aita.

2012-10-01

322

Tumor desmóide tratado com tamoxifeno: relato de caso  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese O tumor desmóide (TD) é uma neoplasia benigna, que se origina de estruturas fasciais ou músculo-aponeuróticas, constituída por proliferação fibroblástica. Ocorre em 4 a 13% dos pacientes com polipose adenomatosa familiar (FAP). Apesar de histologicamente benignos, os TD têm comportamento maligno, se [...] ndo localmente invasivos e com elevada recorrência após ressecção. Os autores relatam um caso de tumor desmóide tratado cirurgicamente no Hospital Governador Israel Pinheiro - IPSEMG e fazem revisão da literatura sobre o tratamento. Abstract in english The desmoid tumors are benign tumors arising from fibroaponeurotic tissue. They occur in 4 to 13% patients who present familial adenomatous polyposis. Although a benign disease, desmoid tumors are focally invasive. They do not metastasize but can be lethal because of aggressive growth with pressure [...] and erosion causing small bowel obstruction. Their tendency to recur (65% to 85%) after removal has encouraged a conservative approach to management. The authors report the case of a patient who presented intra-abdominal desmoid tumor, treated surgically in the Hospital Governador Israel Pinheiro - Belo Horizonte (MG) and discuss the therapeutic options in the literature.

Bruno Juste Werneck, Côrtes; Sinara Mônica de Oliveira, Leite; Marcos Henrique Rocha, Campos; Levindo Alves de, Oliveira.

2006-03-01

323

El Tratado De Dilectione Dei de Balduino de Ford  

Scientific Electronic Library Online (English)

Full Text Available Figura relevante de la Orden del Císter, Balduino de Ford es un autor que se distingue por la originalidad de su espiritualidad. Su tratado De dilectione Dei es una meditación sobre el Primer Mandamiento, que nos invita a amar a Dios "con todo el corazón en sus beneficios, con toda el alma en sus pr [...] omesas, con todas las fuerzas en sus juicios y con toda la mente en sus preceptos". Su reflexión, nutrida de la Biblia y expresada en un lenguaje marcado por la retórica latina, insiste en que el amor perfecto exige del creyente amar lo que a Dios le agrada porque a Él le agrada. Termina identificando prácticamente amor con obediencia Abstract in english Famous figure of the cistercian order, Baldwin of Ford is an author who stands out for the originality of his spirituality. His treatise "De dilectione Dei" is a meditation about the First Comandment, which is an invitation to love God "with all the heart in His benefits, with all the soul in His pr [...] omises, with all the forces in His judgements and with all the mind in His precepts". According to his reflection, fed with the Bible and expressed in a language marked by the latin rhetoric, the perfect love requires to love what is pleasing to God because it pleases Him. Baldwin practically identifies love with obedience

Carlos, Hallet.

324

Neumonías, reporte de dos casos tratados por homeopatía*  

Directory of Open Access Journals (Sweden)

Full Text Available Las neumonías son entidades que afectan al aparato respiratorio, especialmente al pulmón. Su tratamiento habitual es el uso de antibióticos y en ocasiones en cantidades abusivas. En el presente trabajo se describen dos casos que fueron tratados por homeopatía y en los cuales no fue necesario el uso de los antibióticos. Ambas pacientes habían padecido de bronconeumonía en 3 ocasiones anteriores. A las 2 pacientes se les indicó tratamiento con Phosphoro 6 CH durante 1 mes consecutivo a razón de 5 gotas 3 veces al día, y su respuesta fue favorable al tratamiento, al concluir éste se le dio el medicamento de fondo. Hace 6 meses que padecieron la neumonía y se mantienen asintomáticas.Pneumonias are diseases affecting the respiratory system, specially the lungs. Its habitual treatment consists in the use of antibiotics, which are sometimes excessively used. In this paper we describe 2 cases that are treated by homeopathy with no need of antibiotics. Both patients had suffered from bronchopneumonia 3 times before. They were treated with 5 drops of Phosphorus 6 CH 3 times a day during a month and the response was favorable. On concluding the treatment, they continued taking drugs. These subjects suffered from pneumonia 6 months ago and they are still asymptomatic.

Jorge Luis Campistrous Lavaut

1997-06-01

325

Neumonías, reporte de dos casos tratados por homeopatía*  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Las neumonías son entidades que afectan al aparato respiratorio, especialmente al pulmón. Su tratamiento habitual es el uso de antibióticos y en ocasiones en cantidades abusivas. En el presente trabajo se describen dos casos que fueron tratados por homeopatía y en los cuales no fue necesario el uso [...] de los antibióticos. Ambas pacientes habían padecido de bronconeumonía en 3 ocasiones anteriores. A las 2 pacientes se les indicó tratamiento con Phosphoro 6 CH durante 1 mes consecutivo a razón de 5 gotas 3 veces al día, y su respuesta fue favorable al tratamiento, al concluir éste se le dio el medicamento de fondo. Hace 6 meses que padecieron la neumonía y se mantienen asintomáticas. Abstract in english Pneumonias are diseases affecting the respiratory system, specially the lungs. Its habitual treatment consists in the use of antibiotics, which are sometimes excessively used. In this paper we describe 2 cases that are treated by homeopathy with no need of antibiotics. Both patients had suffered fro [...] m bronchopneumonia 3 times before. They were treated with 5 drops of Phosphorus 6 CH 3 times a day during a month and the response was favorable. On concluding the treatment, they continued taking drugs. These subjects suffered from pneumonia 6 months ago and they are still asymptomatic.

Jorge Luis, Campistrous Lavaut; Mayra, Riverón Garrote; Raquel, Pérez Nip.

1997-06-01

326

Differential MR Delayed Enhancement Patterns of Chronic Myocardial Infarction between Extracellular and Intravascular Contrast Media  

Science.gov (United States)

Objectives Because the distribution volume and mechanism of extracellular and intravascular MR contrast media differ considerably, the enhancement pattern of chronic myocardial infarction with extracellular or intravascular media might also be different. This study aims to investigate the differences in MR enhancement patterns of chronic myocardial infarction between extracellular and intravascular contrast media. Materials and Methods Twenty pigs with myocardial infarction underwent cine MRI, first pass perfusion MRI and delayed enhancement MRI with extracellular or intravascular media at four weeks after coronary occlusion. Myocardial blood flow (MBF) was determined with microsphere measurement. The infarction histopathological changes were evaluated by hematoxylin and eosin staining and Masson's trichrome method. Results Cine MRI revealed the reduced wall thickening in chronic infarction compared with normal myocardium. Moreover, significant wall thinning in chronic infarction was observed in cine MRI. Peak first-pass signal intensity didn’t significantly differ between chronic infarction and normal myocardium no matter what kinds of contrast media. At the following delayed enhancement phase, extracellular media-enhanced signal intensity was significantly higher in chronic infarction than in normal myocardium. Conversely, intravascular media-enhanced signal intensity was almost equivalent among chronic infarction and normal myocardium. At four weeks after infarction, MBF in chronic infarction approached to that in normal myocardium. Large thick-walled vessels were detected at peri-infarction zones. The cardiomyocytes were replaced by scar tissue consisting of dilated blood vessels and discrete fibers of collagen. Conclusions Chronic infarction was characterized by the significantly reduced wall thickening and the definite wall thinning. First-pass myocardial perfusion defect was not detected in chronic infarction with two media due to the significantly recovered MBF and well-developed collateral vessels. Infarction remodeling enlarged the extracellular compartment, which was available for extracellular media but not accessible to intravascular media. Extracellular media identified chronic infarction as the hyper-enhancement; nonetheless, intravascular media didn’t provide delayed enhancement. PMID:25816056

Wang, Jian; Xiang, Bo; Lin, Hung Yu; Liu, Hongyu; Freed, Darren; Arora, Rakesh C.; Tian, Ganghong

2015-01-01

327

Consensus standards for acquisition, measurement, and reporting of intravascular optical coherence tomography studies : a report from the international working group for intravascular optical coherence tomography standardization and validation  

DEFF Research Database (Denmark)

The purpose of this document is to make the output of the International Working Group for Intravascular Optical Coherence Tomography (IWG-IVOCT) Standardization and Validation available to medical and scientific communities, through a peer-reviewed publication, in the interest of improving the diagnosis and treatment of patients with atherosclerosis, including coronary artery disease.

Tearney, Guillermo J; Regar, Evelyn

2012-01-01

328

Processos linfoproliferativos da pele: parte 2 - linfomas cutâneos de células T e de células NK Processos linfoproliferativos da pele: part 2 - cutaneous T-cell and NK-cell lymphomas  

OpenAIRE

Os linfomas cutâneos de células T/NK constituem um grupo de doenças linfoproliferativas extranodais atualmente classificadas e subdivididas de acordo com o comportamento clínico segundo consenso da Organização Mundial de Saúde e da Organização Européia para Pesquisa e Tratamento do Câncer. Os linfomas cutâneos de células T/NK de comportamento clínico indolente compreendem a micose fungóide clássica, a micose fungóide foliculotrópica, a reticulose pagetóide, a cútis laxa gr...

José Antonio Sanches Jr; Moricz, Claudia Zavaloni M.; Cyro Festa Neto

2006-01-01

329

Tratamento cirúrgico do linfoma gástrico primário / Surgical treatment of primary gastric lymphoma  

Scientific Electronic Library Online (English)

Full Text Available OBJETIVO: o objetivo deste estudo retrospectivo foi analisar os resultados de 25 doentes com linfoma gástrico primário operados com intenção curativa. MÉTODO: os dados foram obtidos pela revisão dos prontuários e contato com os doentes ou familiares. A doença foi estadiada pelo sistema Ann Arbor mod [...] ificado por Musshoff e Schmidt-Vollmer e a classificação histológica utilizada foi o sistema de Kiel. O esquema de radioterapia utilizado foi o CHOP e a radioterapia aplicada foi de 2000 a 4000 cGy. RESULTADOS: os sintomas e sinais clínicos assemelhavam-se aos da doença péptica ulcerosa ou do carcinoma gástrico Obteve-se o diagnóstico pré-operatório pela biópsia endoscópica em três casos e a exploração cirúrgica foi necessária para o diagnóstico nos restantes. No pré-operatório, sete doentes (30,4%) foram submetidos ao mielograma, que foi normal. Todos os pacientes foram submetidos à ressecção (12 gastrectomias subtotais e 13 gastrectomias totais) com retirada dos linfonodos regionais. Dez doentes (40%) receberam tratamento complementar (quimioterapia e/ou radioterapia). O estadiamento foi significativamente mais avançado nas lesões fundocárdicas e nos mais idosos e a sobrevida média foi de 31,5 meses. CONCLUSÕES: nesta série, as variáveis que influenciaram significativamente os índices de sobrevida foram a idade e o estádio avançados, o tamanho da lesão maior que 6,0cm e a realização do tratamento adjuvante pós-operatório (p Abstract in english BACKGROUND: we analyzed the results from 25 patients with primary gastric lymphoma operated with curative intention. METHODS: Data were obtained retrospective ly and by contacting patients or theirs relatives. The disease was staged using the Ann Arbor system for non-Hodgkin's lymphoma, as modified [...] by Musshoff and Schmidt-Vollmer, and classified according to Kiel's system. RESULTS: The signs and symptoms were similar to those of peptic ulcer disease or gastric carcinoma. Preoperative diagnosis was obtained by endoscopic biopsy in three cases and by surgical exploration in the remaining. Seven patients (28%) were submitted to myelograms, which were normal in all cases. All patients were submitted to resection (12 subtotal gastrectomies and 13 total gastrectomies) with removal of regional lymph nodes. Ten of them (40%) received complementary treatment (chemotherapy and/or radiotherapy). The staging was significantly more advanced in fundocardiac lesions and in more elderly patients, and the average survival was 31.5 months. CONCLUSIONS: in this series, the variables that influenced significantly survival rate were age, advanced stage, size of the lesion higher than 6,0 cm, and adjuvant postoperative treatment (p

Jaques, Waisberg; Sansom Henrique, Bromberg; Simone Moraes, Stephani; Maria Isete Fares, Franco; Antônio Cláudio de, Godoy; Fábio Schmidt, Goffi.

2001-04-01

330

Mapping of arterial transit time by intravascular signal selection.  

Science.gov (United States)

The arterial transit time (?a ) is a potentially important physiological parameter which may provide valuable information for the characterization of cerebrovascular diseases. The present study shows that ?a can be measured by arterial spin labeling (ASL) applied quasi-continuously in an amplitude-modulated fashion at the human neck. Imaging was performed using short repetition times and excitation flip angles of 90°, which resulted in the selection of an ASL signal of mostly intravascular origin. Model-independent estimates of ?a were obtained directly from the temporal shift of the ASL time series. An extended two-compartment perfusion model was developed in order to simulate the basic features of the proposed method and to validate the evaluation procedure. Vascular structures found in human ?a maps, such as the circle of Willis or cerebral border zones, hint at the sensitivity of the method to most sizes of arterial vessels. Group-averaged values of ?a measured from the carotid bifurcation to the tissue of interest in selected regions of the human brain ranged from 925?ms in the insular cortex to 2000?ms in the thalamic region. PMID:24610794

Mildner, Toralf; Müller, Karsten; Hetzer, Stefan; Trampel, Robert; Driesel, Wolfgang; Möller, Harald E

2014-05-01

331

Is antithrombin treatment of disseminated intravascular coagulation a quixotic goal?  

Science.gov (United States)

The development of disseminated intravascular coagulation (DIC) is associated with increased sepsis mortality. Antithrombin (AT) is one of several anticoagulants that have been studied in randomized trials of sepsis without benefit. In a recent study, Iba and colleagues reviewed data from patients who were treated for sepsis-related DIC with two lower doses of AT concentrate than studied in prior trials. Patients received 1,500 IU/day (n = 259) or 3,000 IU/day (n = 48) of AT for 3 days. All patients had baseline antithrombin activity <40% and there was no placebo group. The AT 3,000 group had higher 28-day survival as well as a higher rate of DIC resolution than the AT 1,500 group. Though intriguing, the study findings are limited by the non-randomized retrospective nature of the findings, which resulted in baseline differences in multiple confounders that affect mortality, as well as the lack of a placebo group to compare outcomes. PMID:25673027

Seam, Nitin; Suffredini, Anthony F

2014-01-01

332

Progress in diagnosis and treatment for disseminated intravascular coagulation.  

Science.gov (United States)

As the development of a hypercoagulable state in the setting of disseminated intravascular coagulation (DIC) induces localized infection, therapy for DIC should be evaluated according to the findings of examinations for both severe sepsis and DIC. DIC is classified into the following types: "bleeding type," "organ failure type," "asymptomatic type," and "complication type." The "bleeding type" and "organ failure type" are considered to reflect the "plasmin inhibitor (PI) deficiency type" and "antithrombin (AT) deficiency type," respectively. In order to improve the diagnosis of DIC, in particular limitations in global coagulation tests, the Japanese Society of Thrombosis and Hemostasis recently proposed tentative diagnostic criteria for DIC using hemostatic molecular markers and AT. The recommendations for treatment of DIC, especially the use of AT concentrates, recombinant activated protein C and thrombomodulin, vary among several guidelines for the management of DIC. These agents inhibit the effects of key proteases in activating coagulation and consequently exert an anti-inflammatory effect on DIC. Hence, it is necessary to extensively evaluate these agents in well-conducted clinical trials. PMID:25765797

Wada, Hideo; Matsumoto, Takeshi; Aota, Takumi; Yamashita, Yoshiki

2015-01-01

333

Quantitative recovery of pulmonary intravascular macrophages from sheep lungs.  

Science.gov (United States)

Pulmonary intravascular macrophages (PIMs) adhere to the endothelium of lung capillaries and sequester circulating particles and pathogens from the blood. Iron oxide (gamma Fe2O3) 5 mg/kg, administered intravenously, specifically labeled PIMs in situ within the living sheep. Attempts to isolate gamma Fe2O3-labeled PIMs using vascular perfusion (VP) procedures yielded few cells. To improve recovery of PIMs, a proteolytic lung digestion (PLD) procedure was developed. Following PLD, gamma Fe2O3-containing PIMs were recovered by magnets and the amount of gamma Fe2O3 present measured by fluxgate magnetometry. Proteolytic lung digestion recovered 34% of the total gamma Fe2O3 in lung samples and yielded 2 x 10(5) PIMs/g lung with 95% viability. In contrast, VP recovered only 3% of the total gamma Fe2O3 in the lung; furthermore, less than 2% of the recovered gamma Fe2O3 was cell associated. Proteolytic lung digestion followed by magnetic separation is an effective way to recover viable sheep PIMs for in vitro study. PMID:7996045

Rogers, R A; Tasat, D R; Warner, A E; Brain, J D

1994-12-01

334

Status Epilepticus as the Initial Presentation of Intravascular Lymphoma  

Science.gov (United States)

Intravascular lymphoma (IVL) is a rare disease form of malignant lymphoma, and it is characterised by the selective growth of lymphoma cells within the lumina of vessels. Identification of this disease at an early stage is difficult because of non-specific clinical symptoms and neuroradiological findings. Most reported IVL cases are diagnosed at post-mortem following autopsy. We report the case of a patient who presented with status epilepticus (SE) as the initial manifestation of IVL. Despite the administration of anti-convulsant agents and general care the patient's condition deteriorated rapidly after admission, culminating in death due to respiratory failure and heart failure 21 days after the onset of symptoms. Post-mortem examination revealed IVL in the brain and multiple organs. Epileptic seizures often appear during the clinical course of IVL; however, they occur most frequently at advanced stages. Diagnosis of IVL that first presents with SE is of clinical importance because the treatment and prognosis of acute SE arising from IVL are different from those of SE originating from other causes. PMID:22807906

Hiraga, Akiyuki; Ozaki, Daisuke; Kamitsukasa, Ikuo; Araki, Nobuyuki; Arai, Kimihito

2012-01-01

335

Intra-Vascular Neural Interface with Nano-Wire Electrode  

Science.gov (United States)

A less-invasive recording technique capable of simultaneously monitoring the activity of significant number (103 ? 104) of neurons is a vital step in developing an effective brain-machine interface. Although there are many excellent techniques for recording activities of a single neuron or a group of neurons, there is no methodology for accessing large number of cells in a behaving experimental animal or human individual. Brain vascular parenchyma offers the promising candidate to solve this problem. We have proposed the use of myriad of nano-wire-electrodes that are introduced into the Central Nervous System through the vascular system to address any brain area. In this study we design a microcatheter for ex vivo experiments. Using a Wollaston platinum wire we design a submicron-scale electrode, and develop the fabrication method. We then evaluate the mechanical property of the electrode to flow into the intricacies of the capillary bed in ex vivo Xenopus laevis. Furthermore, we demonstrate the feasibility of intravascular recording in the spinal cord of Xenopus laevis.

Watanabe, Hirobumi; Takahashi, Hirokazu; Nakao, Masayuki; Walton, Kerry; Llinás, Rodolfo R.

336

Biochemistry and pathophysiology of intravascular and intracellular lipolysis  

Science.gov (United States)

All organisms use fatty acids (FAs) for energy substrates and as precursors for membrane and signaling lipids. The most efficient way to transport and store FAs is in the form of triglycerides (TGs); however, TGs are not capable of traversing biological membranes and therefore need to be cleaved by TG hydrolases (“lipases”) before moving in or out of cells. This biochemical process is generally called “lipolysis.” Intravascular lipolysis degrades lipoprotein-associated TGs to FAs for their subsequent uptake by parenchymal cells, whereas intracellular lipolysis generates FAs and glycerol for their release (in the case of white adipose tissue) or use by cells (in the case of other tissues). Although the importance of lipolysis has been recognized for decades, many of the key proteins involved in lipolysis have been uncovered only recently. Important new developments include the discovery of glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1), the molecule that moves lipoprotein lipase from the interstitial spaces to the capillary lumen, and the discovery of adipose triglyceride lipase (ATGL) and comparative gene identification-58 (CGI-58) as crucial molecules in the hydrolysis of TGs within cells. This review summarizes current views of lipolysis and highlights the relevance of this process to human disease. PMID:23475957

Young, Stephen G.; Zechner, Rudolf

2013-01-01

337

Implications of Donor Disseminated Intravascular Coagulation on Kidney Allograft Recipients  

Science.gov (United States)

Summary Background and objectives Disseminated intravascular coagulation (DIC) is common in deceased kidney donors and is considered a relative contraindication to donation. The significance of donor DIC on recipient kidney function is poorly understood. Additionally, the significance of thrombocytopenia in recipients of kidneys from DIC-positive donors is understudied. Design, setting, participants, & measurements In a retrospective cohort of 162 kidney transplants, the presence of DIC in donors, the occurrence of thrombocytopenia in recipients, and risk factors for delayed or slow graft function (DGF/SGF) were assessed. The effects of DIC donor status on DGF/SGF in the study sample as a whole, and of thrombocytopenia on DGF/SGF in recipients of DIC-positive kidneys specifically, were examined using multiple logistic regression. Results DIC donor status was not associated with occurrence of DGF/SGF, but thrombocytopenia was significantly associated with DIC-positive donor status (P = 0.008). Thrombocytopenia was independently associated with DGF/SGF only in the recipients of DIC-positive kidneys (P = 0.005). Patient and graft survival at 1 year were not affected by donor DIC status or by thrombocytopenia status. Conclusions Donor DIC was not associated with short-term suboptimal graft function, defined as DGF/SGF, nor with long-term patient or graft survival. However, thrombocytopenia appears to portend DGF/SGF in recipients of DIC-positive kidneys and may be a clinical sign on which the basis of therapeutic decisions could be undertaken. PMID:21372214

Shafique, Shahzad; McCullagh, Johanna; Diederich, Dennis A.; Winklhofer, Franz T.; Wetmore, James B.

2011-01-01

338

Optimization of intravascular brachytherapy treatment planning in peripheral arteries.  

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This work deals with the treatment planning optimization for intravascular brachytherapy (IVB) in peripheral arteries. The objective is both to quantitatively study the validity of different hypotheses required for a reliable application of the treatment with current techniques, and to contribute to the definition and the specification of a new optimized procedure taking into account the actual patient's vessel geometry. The detection of vascular luminal surface was performed by an image analysis process, i.e., virtual active navigation, applied to standard CT data. Dose distribution was calculated according to the formalism proposed and recommended by the AAPM in TG43 and TG60. A method combining simulated annealing and BFGS algorithms was applied to optimize the parameters associated with the dwell points such as their number, positions, and dwell times. Dose-surface histogram (DSH) was used to evaluate the dose distribution results. Four levels of accuracy in target surface description were tested. The application of this optimization method to four different CT data sets including patient data, phantom and animal models showed that the treatment plan can be improved when the actual vessel geometry has been taken into account. PMID:17574815

Zhou, Zhengdong; Haigron, Pascal; Shu, Huazhong; Yu, Wenxue; Moisan, Cécile; Manens, Jean-Pierre; Lucas, Antoine; Luo, Limin

2007-09-01

339

Effects of intravascular contrast media on blood-brain barrier  

International Nuclear Information System (INIS)

The effects upon the rabbit blood-brain barrier after intracarotid injection of two non-ionic contrast media, iopentol (a monomer) and iodixanol (a dimer) were compared. Iothalamate and iohexol were used as reference substances. 99Tcm-DTPA, 125I-HSA and Trypsin blue were used as tracers in order to demonstrate various degrees of damage to the barrier. Injection of iothalamate led to large extravasation of 99Tcm-DTPA, 125I-HSA and Trypan blue which means severe damage of the blood-brain barrier. Injection of iopentol and iohexol resulted in some extravasation of all three tracers used, whereas injection of iodixanol only led to extravasation of the small molecule tracer 99Tcm-DTPA demonstrating minor changes of the barrier. At computed tomography of the brain with intravascular contrast medium enhancement it is safer to use iodixanol than iothalamate. Iodixanol is expected to cause even less adverse effects to the brain after intraarterial injection than iopentol and iohexol. (orig.)

340

Estudio histológico e inmunofenotípico de linfoma canino en el centro de México / Histological and immunophenotypic study of canine lymphoma in the center of Mexico  

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Full Text Available El inmunofenotipo constituye un factor importante en el pronóstico del linfoma canino. Se ha demostrado que perros con linfoma de células B presentan tiempos de sobrevivencia más largos que los perros con linfoma de células T. Los antígenos CD3 y CD79a son los marcadores más utilizados en inmunohist [...] oquímica para la determinación del fenotipo celular T y B, respectivamente, en muestras fijadas en formalina y conservadas en bloques de parafina. En este estudio se describen las características morfológicas e inmunofenotípicas de 31 casos de linfoma en México, de casos del archivo del Departamento de Patología de la Facultad de Medicina Veterinaria y Zootecnia de la Universidad Nacional Autónoma de México. Para la clasificación histológica se utilizó el sistema del National Cancer Institute-Working Formulation (NCI-WF). Catorce casos (45.16%) correspondieron a células B, 15 (48.39%) a células T, y dos (6.45%) fueron de origen indeterminado. Histopatológicamente, el linfoma difuso de células grandes fue el tipo más común, representó 38.71% de los casos; le siguieron los siguientes linfomas: linfocítico, inmunoblástico y linfoblástico. Los linfomas de grado intermedio a alto representaron 77.42% de los casos. En este estudio se encontró mayor prevalencia de linfoma de células T. Los resultados en este trabajo pudieran indicar una diferencia en la prevalencia en el inmunofenotipo del linfoma canino en México, en relación con otras zonas geográficas. Abstract in english Immunophenotype constitutes an important factor in the prognosis of canine lymphoma. It has been demonstrated that dogs with B-cell lymphomas have a longer life span than those with T-cell lymphomas. CD3 and CD79a antigens are the most common markers used for the immunohistochemical determination of [...] T-cell and B-cell on formalin-fixed paraffin wax-embedded canine lymphoma tissues. This study describes the morphological and immunophenotypic characteristics of 31 cases of lymphoma in Mexico, obtained from file of the Pathology Department of Veterinary Medicine and Animal Husbandry Faculty of the National Autonomous University of Mexico. The National Cancer Institute-Working Formulation (NCI-WF) classification system was used for the histological classification. Fourteen cases (45.16%) were B cell origin, 15 cases (48.39%) were T-cell origin and 2 cases (6.45%) presented an indeterminate origin. Histopathological diffuse large cell lymphoma (DL) was the most common found (38.71%), followed by lymphocytic (DSL), immunoblastic (IB), intermediate and high-grade lymphomas represented 77.42% of the cases. In this study there was higher prevalence of T-cell lymphoma. The results in this work could indicate prevalent differences in the immunophenotype of the canine lymphoma in Mexico compared with other geographical areas.

Francisco J., Álvarez Berger; Enrique, Aburto Fernández; Aristi Urista, Gerardo; Gilberto, Chávez Gris.

2009-06-01

341

Concomitant thyroid Malt lymphoma and papillary thyroid carcinoma / Concomitância de linfoma MALT de tireoide e carcinoma papilífero de tireoide  

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Full Text Available O objetivo deste trabalho foi descrever um raro linfoma MALT primário de tireoide concomitante com carcinoma papilífero em paciente masculino submetido à tireoidectomia total. O tratamento e o seguimento são discutidos no texto. Paciente masculino com rápido aumento da tireoide sem linfonodomegalias [...] com exames normais. A tireoidectomia total foi indicada e realizada sem complicações. O anatomopatológico mostrou carcinoma papilífero multicêntrico concomitante com linfoma MALT e tireoidite de Hashimoto. A imuno-histoquímica foi positiva para CD 20, CD 43, CD 79, AE1/AE3. O estadiamento clínico não demonstrou evidência de metástases de ambos, Ann Harbor estádio IE, sem sintomas B. Realizado RIT sem radioterapia ou quimioterapia. Atualmente se encontra com tireoglobulina indetectável, sem recidivas ao seguimento de dois anos. Concluiu-se que o linfoma MALT primário de tireoide é raro e o carcinoma papilífero é o mais frequente com boa evolução. A concomitância de ambos é muito rara e o tratamento deve priorizar a neoplasia que apresenta o pior prognóstico no momento da descoberta. Abstract in english The objective of this study was to describe the rare thyroid MALT lymphoma concomitant with papillary thyroid carcinoma in a male patient who was submitted to total thyroidectomy. Treatment and follow-up issues are addressed. Male patient complains of fast thyroid enlargement without lymphadenophaty [...] and normal clinical exams. Total thyroidectomy was indicated and performed without any complications. The pathology showed multicentric papillary thyroid carcinoma, concomitant thyroid MALT lymphoma and Hashimoto's thyroiditis. The immunohistochemistry assay was positive for CD 20, CD 43, CD 79, AE1/AE3. The staging studies showed no evidence of both metastasis, Ann Harbor stage IE, without B symptoms. After RIT no further radiotherapy or chemotherapy was indicated. Nowadays the thyroglobulin is undetectable, without recurrences at two years of follow-up. It was concluded that primary thyroid MALT lymphoma is uncommon being the papillary thyroid carcinoma more frequent. Both occurring concomitantly is very rare and the treatment has to prioritize the tumor of worst prognosis at the discovery moment.

Giulianno Molina de, Melo; Danilo Anunciatto, Sguilar; Cyntia Moniz Figueira, Petiti; André Gustavo Gumz, Eichstaedt; Rogério Ramos, Caiado; Ricardo Antenor de Souza e, Souza.

2010-06-01

342

Concomitant thyroid Malt lymphoma and papillary thyroid carcinoma Concomitância de linfoma MALT de tireoide e carcinoma papilífero de tireoide  

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Full Text Available The objective of this study was to describe the rare thyroid MALT lymphoma concomitant with papillary thyroid carcinoma in a male patient who was submitted to total thyroidectomy. Treatment and follow-up issues are addressed. Male patient complains of fast thyroid enlargement without lymphadenophaty and normal clinical exams. Total thyroidectomy was indicated and performed without any complications. The pathology showed multicentric papillary thyroid carcinoma, concomitant thyroid MALT lymphoma and Hashimoto's thyroiditis. The immunohistochemistry assay was positive for CD 20, CD 43, CD 79, AE1/AE3. The staging studies showed no evidence of both metastasis, Ann Harbor stage IE, without B symptoms. After RIT no further radiotherapy or chemotherapy was indicated. Nowadays the thyroglobulin is undetectable, without recurrences at two years of follow-up. It was concluded that primary thyroid MALT lymphoma is uncommon being the papillary thyroid carcinoma more frequent. Both occurring concomitantly is very rare and the treatment has to prioritize the tumor of worst prognosis at the discovery moment.O objetivo deste trabalho foi descrever um raro linfoma MALT primário de tireoide concomitante com carcinoma papilífero em paciente masculino submetido à tireoidectomia total. O tratamento e o seguimento são discutidos no texto. Paciente masculino com rápido aumento da tireoide sem linfonodomegalias com exames normais. A tireoidectomia total foi indicada e realizada sem complicações. O anatomopatológico mostrou carcinoma papilífero multicêntrico concomitante com linfoma MALT e tireoidite de Hashimoto. A imuno-histoquímica foi positiva para CD 20, CD 43, CD 79, AE1/AE3. O estadiamento clínico não demonstrou evidência de metástases de ambos, Ann Harbor estádio IE, sem sintomas B. Realizado RIT sem radioterapia ou quimioterapia. Atualmente se encontra com tireoglobulina indetectável, sem recidivas ao seguimento de dois anos. Concluiu-se que o linfoma MALT primário de tireoide é raro e o carcinoma papilífero é o mais frequente com boa evolução. A concomitância de ambos é muito rara e o tratamento deve priorizar a neoplasia que apresenta o pior prognóstico no momento da descoberta.

Giulianno Molina de Melo

2010-06-01

343

Linfoma primario del sistema nervioso central en un paciente inmunocompetente / Primary central nervous system lymphoma in an immunocompetent patient  

Scientific Electronic Library Online (English)

Full Text Available SciELO Peru | Language: Spanish Abstract in spanish El linfoma primario del sistema nervioso central (LPSNC) constituye el 2% de los linfomas extranodales y entre 0,3% y 1,5% de todas las neoplasias intracraneales en pacientes inmunocompetentes, siendo más frecuente a partir de los 60 años. Reportamos el caso de un paciente varón de 76 años, sin ante [...] cedentes médicos de importancia, que inició su enfermedad con inestabilidad en la marcha, dificultad para mover el hemicuerpo izquierdo, a predominio braquial, cefalea holocraneal y mareos. Ingresó a emergencia despierto, parcialmente desorientado, Glasgow 14 y ptosis palpebral derecha; además, hemiparesia e hipoestesia izquierda, a predominio crural. Por tomografía computarizada cerebral se evidenció imagen captadora de contraste en región frontoparietal derecha, intra y extra craneal, edema cerebral y desplazamiento de la línea media. Se realizó craneotomía y biopsia del tumor, diagnosticándose linfoma difuso de células grandes B del sistema nervioso central. Fue VIH negativo. Se descartó otro tumor primario y metástasis. Recibió esquema CHOD/BVAM y radioterapia. Evolucionó favorablemente. Según resonancia magnética cerebral postratamiento, desapareció el tumor. Abstract in english Primary central nervous system lymphoma (PCNSL) constitutes 2% of extranodal lymphomas and 0,3%-1,5% of all intracranial neoplasms in immunocompetent patients, being more frequent after the sixth decade of life. We report a case of a 76 year-old man with no antecedents who started his disease with m [...] arch instability, difficulty to move left side of his body with brachial predominance, holocraneal headache and dizziness. He arrived at emergency with Glasgow 14 and right eyelid ptosis. He had left sided hemiparesis and hypoesthesia with crural predominance and occasional disorientation. Brain computed tomography (CT) showed a contrast-enhanced image in the right frontoparietal region with both extra- and intra-cranial components, cerebral edema and middle line deviation. Craniotomy and biopsy of the tumor resulted in diffuse large B cell lymphoma of the central nervous system. The patient was HIV negative. Other primary tumor and metastasis were discarded. He was treated with ‘CHOD/BVAM’ regimen and radiotherapy. He evolved favorably. No tumor was found in the post treatment brain MRI.

José, Málaga-Zenteno; Jersson Alonso, Mamani-Quispe; Mariela, Fuentes Fuentes; José Alonso, Suclla-Velásquez; Julio, Meza Aragón.

2012-07-01

344

Percutaneous Retrieval of Misplaced Intravascular Foreign Objects with the Dormia Basket: An Effective Solution  

International Nuclear Information System (INIS)

Purpose. We report our experience of the retrieval of intravascular foreign body objects by the percutaneous use of the Gemini Dormia basket. Methods. Over a period of 2 years we attempted the percutaneous removal of intravascular foreign bodies in 26 patients. Twenty-six foreign bodies were removed: 8 intravascular stents, 4 embolization coils, 9 guidewires, 1 pacemaker lead, and 4 catheter fragments. The percutaneous retrieval was achieved with a combination of guide catheters and the Gemini Dormia basket. Results. Percutaneous retrieval was successful in 25 of 26 patients (96.2%). It was possible to remove all the intravascular foreign bodies with a combination of guide catheters and the Dormia basket. No complication occurred during the procedure, and no long-term complications were registered during the follow-up period, which ranged from 6 months to 32 months (mean 22.4 months overall). Conclusion. Percutaneous retrieval is an effective and safe technique that should be the first choice for removal of an intravascular foreign body

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Advanced Gastric Cancer Associated with Disseminated Intravascular Coagulation Successfully Treated with 5-fluorouracil and Oxaliplatin  

Science.gov (United States)

Gastric cancer patients with acute disseminated intravascular coagulation experiences a rare but severe complication resulting in a dismal prognosis. We report a case of advanced gastric cancer complicated with disseminated intravascular coagulation with intractable tumor bleeding which was successfully treated with chemotherapy consisting of 5-fluorouracil and oxaliplatin. The patient was a 63-year-old man who complained of abdominal pain, melena, and dyspnea on 24 November 2010. We diagnosed stage IV gastric cancer complicated by disseminated intravascular coagulation. Gastric tumor bleeding was not controlled after procedures were repeated three times using gastrofiberscopy. With the patient's consent, we selected the 5-fluorouracil and oxaliplatin combination chemotherapy for treatment. After one cycle of 5-fluorouracil and oxaliplatin therapy, symptoms of bleeding improved and the disseminated intravascular coagulation process was successfully controlled. The primary tumor and multiple metastatic bone lesions were remarkably shrunken and metabolically remitted after eight cycles of chemotherapy. In spite of progression, systemic chemotherapy is effective in disease control; further, the patient gained the longest survival time among cases of gastric cancer with disseminated intravascular coagulation. PMID:23844328

Lee, Dong Seok; Yoo, Seung Jin; Oh, Ho Suk; Kim, Eun Jung; Oh, Kwang Hoon; Lee, Sang Jin; Park, Jong Kyu; Ahn, Yong Chel; Eom, Dae-Woon

2013-01-01

346

Incidência e aspectos de imagem do linfoma pós-transplante hepático em crianças / Incidence and imaging findings of lymphoma after liver transplantation in children  

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Full Text Available SciELO Brazil | Languages: English, Portuguese Abstract in portuguese OBJETIVO: Avaliar a incidência e os aspectos de imagem do linfoma pós-transplante hepático em crianças. MATERIAIS E MÉTODOS: Foram revisados os prontuários e exames de imagem de crianças submetidas a transplante hepático entre 2000 e 2008 em uma única instituição. RESULTADOS: De 241 crianças submeti [...] das a transplante hepático, com seguimento médio de 41,4 ± 26,4 meses, 16 (6,6%) tiveram linfoma. A média de idade no transplante hepático das crianças que desenvolveram linfoma foi inferior à das crianças que não desenvolveram (23,9 ± 18,9 vs. 38,0 ± 48,9 meses; p = 0,02). O tempo entre o transplante e o desenvolvimento do linfoma variou de 6 a 103 meses. A apresentação clínica e radiológica foi variável e a localização mais comum do tumor foi no abdome (n = 13; 81,3%), seguida de tórax e cabeça e pescoço (n = 4; 25,0% cada). Os achados de imagem incluíram: linfonodomegalias, massas mediastinais, pulmonares e mesentéricas, espessamento parietal de alças intestinais e nódulos hepáticos e renais. Quatro crianças (25,0%) faleceram devido a complicações do linfoma. CONCLUSÃO: Linfomas são complicações relativamente incomuns e potencialmente fatais que podem acontecer a qualquer momento após o transplante hepático em crianças, e que têm diversas apresentações clínicas e de imagem. Abstract in english OBJECTIVE: To evaluate the incidence and imaging findings of lymphoma after liver transplantation in children. MATERIALS AND METHODS: The authors reviewed records and imaging studies of children submitted to liver transplantation in the period between 2000 and 2008 in a single institution. RESULTS: [...] Among 241 children submitted to liver transplantation, with a mean follow-up period of 41.4 ± 26.4 months, 16 (6.6%) had lymphoma. The mean age of the patients who developed lymphoma at the moment of transplantation was lower than in children who did not develop malignancy (23.9 ± 18.9 versus 38.0 ± 48.9 months; p = 0.02). The time interval between liver transplantation and the diagnosis of lymphoma ranged from 6 to 103 months. Clinical and radiological presentation was variable and the abdomen was the most common location of the tumor (n = 13; 81.3%), followed by chest and head and neck (n = 4; 25.0% each). Imaging findings included adenopathy, mediastinal, pulmonary and mesenteric masses, bowel wall thickening and hepatic and renal nodules. Four children (25.0%) died because of complications of lymphoma. CONCLUSION: Lymphomas are relatively uncommon and potentially fatal complications that may occur any time after pediatric liver transplantation, presenting different clinical and imaging findings.

Almir Galvão Vieira, Bitencourt; Paula Nicole Vieira, Pinto; Maria Fernanda Arruda, Almeida; Wagner Santana, Cerqueira; André Moreira de, Assis; Adriana Michiko da Silva Tanaka, Rodrigues; Rubens, Chojniak.

2012-02-01

347

Linfoma de células B de la zona marginal extranodal del tejido linfoide asociado a mucosas (malt) primario de esófago: Presentación de un caso  

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Full Text Available El tracto gastrointestinal es la localización mas frecuente de los linfomas no Hodgkin extranodales, sin embargo, el compromiso del esófago es extremadamente raro, con una incidencia menor del 1% de todos los pacientes con linfoma. Se ha descrito con mayor frecuencia afectación secundaria del esófag [...] o como parte de un compromiso extenso de un linfoma gástrico o mediastinal. Se presenta el caso de paciente femenina, de 59 años de edad, con síntomas dispépticos de 2 meses de evolución. En la Endoscopia Digestiva Superior (EDS) se evidencia en tercio distal de esófago, lesión elevada, de 1cm de diámetro, con características similares al resto de la mucosa, móvil. La biopsia Endoscópica revela la presencia de un linfoma MALT de bajo grado confirmado por inmunohistoquímica. Se indicó tratamiento de erradicación para H pylori, y los estudios de extensión fueron normales. Posteriormente se realizó resección mucosal endoscópica, donde se observaron grupos aislados de linfocitos neoplásicos, con bordes de resección libres. Paciente con seguimiento endoscópico normal. Pocos casos han sido reportados en la literatura acerca de linfomas MALT de esófago, por lo tanto las características clínicas y biológicas de estos linfomas no están claramente establecidas. Es necesario el estudio y seguimiento de estos casos, para determinar los posibles factores de riesgo y así aplicar las medidas preventivas. Abstract in english The gastrointestinal tract is the most common extra nodal site involved in Non- Hodgkin's lymphoma. However, esophageal involvement is extremely rare, accounting for less than 1% of patients with lymphoma. It has been described that esophageal involvement in lymphoma is more often a result of contig [...] uous spread from mediastinal lymph nodes or from an extended gastric lymphoma. A 59 year old female consulted for dyspeptic symptoms. Endoscopic examination revealed a small submucosal mass, that measured 1 cm located at the lower thoracic esophagus. The biopsy reported a Malt lymphoma that was confirmed by immunohistochemistry. She received therapy for H. pylori eradication. Endoscopic mucosal resection was performed, and isolated groups of atypical lymphocytes were found, with free resection margins. Endoscopic follow up has been normal. Few cases have been reported in literature, therefore biological and clinical characteristics of MALT lymphoma of the esophagus are currently unknown, further study is needed to establish risk factors in order to be able to take preventive measures.

L, Zambrano; M, Calderón; S, Romero; S, Peraza; L, Fuenmayor; K, Bustamante; N, Zambrano; D, Parlapiano; D, Castro; A, Morales; J, García.

2007-03-01

348

Accumulation of /sup 99m/Tc-sulfur colloid by the lung and kidney following disseminated intravascular coagulation  

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A patient is described who demonstrated accumulation of /sup 99m/Tc-sulfur colloid in both the lung and kidney following treatment for disseminated intravascular coagulation. This phenomenon has been demonstrated experimentally in animals following the induction of disseminated intravascular coagulation, but to our knowledge has not been previously described in humans.

Smith, F.W.; Brown, R.G.; Ash, J.M.; Gilday, D.L.

1980-06-01

349

Accumulation of /sup 99m/Tc-sulfur colloid by the lung and kidney following disseminated intravascular coagulation  

International Nuclear Information System (INIS)

A patient is described who demonstrated accumulation of /sup 99m/Tc-sulfur colloid in both the lung and kidney following treatment for disseminated intravascular coagulation. This phenomenon has been demonstrated experimentally in animals following the induction of disseminated intravascular coagulation, but to our knowledge has not been previously described in humans

350

Leishmaniosis laríngea recidivante: un caso inusual en un paciente inmunocompetente tratado con corticoides / Recidivant laryngeal leishmaniosis: an unusual case in an immunocompetent patient treated with corticosteroids  

Scientific Electronic Library Online (English)

Full Text Available La leishmaniosis es una parasitosis de evolución crónica; en Argentina, sus agentes etiológicos principales pertenecen al complejo Leishmania (Viannia) braziliensis, habitualmente asociado a lesiones cutáneas y mucocutáneas. Informamos en este trabajo un caso de leishmaniosis laríngea en un hombre d [...] e 29 años procedente de Jujuy, quien a raíz de múltiples subdiagnósticos portaba esta parasitosis desde hacía 20 años. En el año 2008 este paciente consulta por disfonía crónica y trastornos en las vías aéreas superiores, refiere que fue sometido a terapias con tuberculostáticos, antifúngicos y corticoides desde 2002. Diferentes biopsias y fibroscopías revelaron los siguientes diagnósticos: laringitis granulomatosa inespecífica, laringitis compatible con tuberculosis, laringitis compatible con histoplasmosis, linfoma Natural Killer extraganglionar a células pequeñas. Finalmente, estudios realizados en nuestro hospital demostraron la presencia de una laringe granulomatosa en toda su extensión, amastigotes intra y extracelulares de Leishmania spp., ausencia de formas compatibles con Micobacterias e Histoplasma, y laringitis crónica vinculable a Leishmania spp. El paciente realizó tratamiento con antimoniato de N-metil-glucamina y demostró una muy buena evolución clínica tras ser examinado 2 meses después. Si bien la leishmaniosis laríngea como lesión única no es la presentación prevalente de esta zoonosis, su estudio amerita especial atención en pacientes tratados con corticoides, pues esto evitará un diagnóstico tardío y las mayores consecuencias asociadas a la morbimortalidad propia de esta parasitosis. Abstract in english Leishmaniosis is a chronic parasitic disease, which in Argentina is mainly caused by protozoa belonging to the Leishmania (Viannia) braziliensis complex, leading to cutaneous and mucosal pathologies. We report a rare case of laryngeal leishmaniosis in a 29 year-old man from Jujuy province, Argentina [...] , who had been misdiagnosed with other pathologies, carrying this infectious disease for about 20 years. During 2008, the patient was admitted with complaints of progressive hoarseness of the voice and dyspnea. He also reported having received tuberculostatics, antifungal and corticosteroids treatments since 2002. Different biopsies and direct laryngoscopic exams revealed inespecific granulomatous larynx, TBC-related laryngitis, laryngitis related to Histoplasma infection, extra-nodal Natural Killer-cell lymphoma. Finally, the patient was evaluated at the University Hospital and the final diagnosis was: granulomatous larynx, intra and extra-cytoplasmic Leishmania spp amastigotes, negative for TBC and Histoplasma cultures, and chronic laryngitis related to Leishmania infection, according to the laryngeal endoscopy, microbiological and histopathological exams, respectively. The patient received pentavalent antimonial treatment and his condition improved after 2 months of follow-up. Primary laryngeal leishmaniosis is rare and this localization does not belong to the most prevalent mucosal leishmaniosis. However, this parasitic disease warrants special concern, especially in patients who received prolonged corticosteroid treatments, in order to avoid a misdiagnosis of this disease.

R., Casero; L., Laconte; L., Fraenza; N., Iglesias; C., Quinteros Greco; ML., Villablanca.

2010-06-01

351

Leishmaniosis laríngea recidivante: un caso inusual en un paciente inmunocompetente tratado con corticoides Recidivant laryngeal leishmaniosis: an unusual case in an immunocompetent patient treated with corticosteroids  

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Full Text Available La leishmaniosis es una parasitosis de evolución crónica; en Argentina, sus agentes etiológicos principales pertenecen al complejo Leishmania (Viannia braziliensis, habitualmente asociado a lesiones cutáneas y mucocutáneas. Informamos en este trabajo un caso de leishmaniosis laríngea en un hombre de 29 años procedente de Jujuy, quien a raíz de múltiples subdiagnósticos portaba esta parasitosis desde hacía 20 años. En el año 2008 este paciente consulta por disfonía crónica y trastornos en las vías aéreas superiores, refiere que fue sometido a terapias con tuberculostáticos, antifúngicos y corticoides desde 2002. Diferentes biopsias y fibroscopías revelaron los siguientes diagnósticos: laringitis granulomatosa inespecífica, laringitis compatible con tuberculosis, laringitis compatible con histoplasmosis, linfoma Natural Killer extraganglionar a células pequeñas. Finalmente, estudios realizados en nuestro hospital demostraron la presencia de una laringe granulomatosa en toda su extensión, amastigotes intra y extracelulares de Leishmania spp., ausencia de formas compatibles con Micobacterias e Histoplasma, y laringitis crónica vinculable a Leishmania spp. El paciente realizó tratamiento con antimoniato de N-metil-glucamina y demostró una muy buena evolución clínica tras ser examinado 2 meses después. Si bien la leishmaniosis laríngea como lesión única no es la presentación prevalente de esta zoonosis, su estudio amerita especial atención en pacientes tratados con corticoides, pues esto evitará un diagnóstico tardío y las mayores consecuencias asociadas a la morbimortalidad propia de esta parasitosis.Leishmaniosis is a chronic parasitic disease, which in Argentina is mainly caused by protozoa belonging to the Leishmania (Viannia braziliensis complex, leading to cutaneous and mucosal pathologies. We report a rare case of laryngeal leishmaniosis in a 29 year-old man from Jujuy province, Argentina, who had been misdiagnosed with other pathologies, carrying this infectious disease for about 20 years. During 2008, the patient was admitted with complaints of progressive hoarseness of the voice and dyspnea. He also reported having received tuberculostatics, antifungal and corticosteroids treatments since 2002. Different biopsies and direct laryngoscopic exams revealed inespecific granulomatous larynx, TBC-related laryngitis, laryngitis related to Histoplasma infection, extra-nodal Natural Killer-cell lymphoma. Finally, the patient was evaluated at the University Hospital and the final diagnosis was: granulomatous larynx, intra and extra-cytoplasmic Leishmania spp amastigotes, negative for TBC and Histoplasma cultures, and chronic laryngitis related to Leishmania infection, according to the laryngeal endoscopy, microbiological and histopathological exams, respectively. The patient received pentavalent antimonial treatment and his condition improved after 2 months of follow-up. Primary laryngeal leishmaniosis is rare and this localization does not belong to the most prevalent mucosal leishmaniosis. However, this parasitic disease warrants special concern, especially in patients who received prolonged corticosteroid treatments, in order to avoid a misdiagnosis of this disease.

R. Casero

2010-06-01

352

Linfoma Burkitt del seno esfenoidal en pediatría: Reporte de caso / Burkitt Lymphoma of the Sphenoid Sinus in Children: Case Report  

Scientific Electronic Library Online (English)

Full Text Available SciELO Argentina | Language: Spanish Abstract in spanish Se reporta un caso de linfoma Burkitt del seno esfenoidal en un paciente de sexo masculino, de 3 años de edad, de raza caucásica. Presentaba un cuadro clínico de 10 días de evolución con deterioro del sensorio, vómitos y amaurosis bilateral y, por tomografía computada y resonancia magnética, se iden [...] tificó una masa que comprometía el seno esfenoidal. Se arribó al diagnóstico por anatomía patológica e inmunomarcación. Abstract in english We report a case of Burkitt lymphoma of the sphenoid sinus in a 3 year-old caucasian male patient. He presented a clinical condition of 10 days of improvement with a sensory deterioration, vomiting and bilateral amaurosis. A mass which compromised the sphenoid sinus was identified by computed tomogr [...] aphy and magnetic resonance imaging. The diagnosis could be reached by pathology and immunohistochemical studies.

Jorge, Docampo; Carolina, Mariluis; Gustavo, Civitarese; Carlos, Castillo; Carlos, Morales; Claudio, Bruno.

2011-06-01

353

Linfoma Burkitt del seno esfenoidal en pediatría: Reporte de caso Burkitt Lymphoma of the Sphenoid Sinus in Children: Case Report  

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Full Text Available Se reporta un caso de linfoma Burkitt del seno esfenoidal en un paciente de sexo masculino, de 3 años de edad, de raza caucásica. Presentaba un cuadro clínico de 10 días de evolución con deterioro del sensorio, vómitos y amaurosis bilateral y, por tomografía computada y resonancia magnética, se identificó una masa que comprometía el seno esfenoidal. Se arribó al diagnóstico por anatomía patológica e inmunomarcación.We report a case of Burkitt lymphoma of the sphenoid sinus in a 3 year-old caucasian male patient. He presented a clinical condition of 10 days of improvement with a sensory deterioration, vomiting and bilateral amaurosis. A mass which compromised the sphenoid sinus was identified by computed tomography and magnetic resonance imaging. The diagnosis could be reached by pathology and immunohistochemical studies.

Jorge Docampo

2011-06-01

354

Linfoma No Hodgkin, manifestaciones oftalmológicas: Presentación de 1 caso / Non-Hodgkin's lymphoma, ophthalmological manifestations: A case report  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Se presenta un paciente con Linfoma no Hodgkin linfocítico estadio IV y Retinosis Pigmentaria de base diagnosticado en el Centro de Referencia Nacional de Retinosis Pigmentaria, con manifestaciones oftalmológicas de esta neoplasia, remitido, además, al Instituto Nacional de Oncología y Radiobiología [...] . Se ilustra con imágenes estas lesiones infrecuentes. Abstract in english A patient with lymphocytic stage IV non-Hodgkin's lymphoma and base Retinitis Pigmentosa diagnosed at the National Reference Center of Retinitis Pigmentosa is presented. The patient, who showed ophthalmological manifestations of this neoplasia was also referred to the National Institute of Oncology [...] and Radiobiology. These uncommon injuries are illustrated with images.

Tomás, Ramírez Castro; María E., Lorenzo González.

2003-12-01

355

Síndrome Nefrótico y Linfoma de Hodgkin: Reporte de dos casos / Nephrotic syndrome and Hodgkin lymphoma: A case report  

Scientific Electronic Library Online (English)

Full Text Available SciELO Peru | Language: Spanish Abstract in spanish Se presentan dos pacientes con síndrome nefrótico sensibles a corticoides y lesiones compatibles con Linfoma de Hodgkin. En uno se encontró una masa mediastinal en la evolución y en el otro un nódulo pulmonar. En ambos casos la biopsia mostró, a la microscopia óptica, hallazgos compatibles con linfo [...] ma de Hodgkin Luego de la quimioterapia presentaron remisión de la enfermedad renal.(Rev Med Hered 2011;22:182-185). Abstract in english We report two patients with Corticosensitive nephrotic syndrome and Hodgkin Lymphoma. In one case was found a mediastinal mass during its evolution and in the other, a lung nodule. In both cases, biopsy was performed and the results were consistent with Hodgkin Lymphoma. After chemotherapy had remis [...] sion of renal disease.(Rev Med Hered 2011;22:182-185).

Luciola, Vásquez; Reyner, Loza; Eduardo, Chaparro; Katiuska, Noriega; Nancy, Mayo.

2011-10-01

356

Linfoma de células en anillo de sello que simula carcinoma mucosecretante / Signet ing cell lymphoma mimicking mucin-producing carcinoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Argentina | Language: Spanish Abstract in spanish El linfoma de células en anillo de sello es una neoplasia poco frecuente, caracterizada por la presensencia de grandes células de citoplasma vacuolado, claro, similar a los encontrados en adeno-carcinomas mucosecretantes. Se ha descripto en ganglios linfáticos y tejidos extralinfáticos. Se presenta [...] el caso de un paciente varón de 59 años con linfoma de células en anillo de sello localizado en pared lateral de orofaringe. Esta localización creemos que no ha sido descripta anteriormente. La histología mostró células en anillo de sello y el inmunofenotipo tumoral fue: vimentina, CD45, CD20, Ig M y cadenas kappa positivos, siendo la fracción de crecimiento tumoral alta (Ki 67:70%). El paciente evolucionó desfavorablemente y falleció a los dos meses del diagnóstico sin recibir tratamiento. Abstract in english Signet ring cell lymphoma is a rare neoplasm caracterized by large, vacuolated and clear cells mimicking mucin-producing adenocarcinoma. It is localized in nodal and extranodal sites. A case of a 59 years old male, with a diffuse lymphoma signet ring cell type localized on oropharingeal mucosa is re [...] ported. The histopathology study showed signet ring cells and the immunophenotype was: vimentine(+), CD45(+), CD20(+), Ig M(+), Kappa chain(+) and high index proliferative activity of neoplastic cells (Ki 67:70%). After a review of the literature and previous reports, we could not find a similar case in this anatomic site. The patient had a unfavourable clinical course and died two months after the diagnosis without receiving any treatment.

Ana María, Saenz de Chirife; Erica, Rojas Bilbao; Liliana, Gimenez; Lina, Marino; Francisco, Celeste.

2004-12-01

357

Primary cutaneous anaplastic large-cell lymphoma - case report / Linfoma cutâneo primário de grandes células anaplásicas - relato de caso  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese Linfoma cutâneo primário de grandes células T anaplásicas faz parte do espectro de processos linfoproliferativos cutâneos CD30+ e caracteriza-se por nódulos únicos ou multifocais, ulcerados, autorregressivos e recidivantes. Pode haver disseminação extracutânea, principalmente para linfonodos regiona [...] is. O histológico mostra infiltrado difuso, não-epidermotrópico, grandes células linfóides anaplásicas de imunohistoquímica CD30+, CD4+, EMA-/+, ALK-, CD15- e TIA1-/+. O prognóstico é bom e independe da invasão ganglionar. Radioterapia, retirada da lesão e/ou metotrexato em baixas doses são os tratamentos de escolha. Este estudo relata o caso de uma mulher, 57 anos, com Linfoma cutâneo primário de grandes células T com lesões multifocais e que, após 7 anos, evoluiu com acometimento pulmonar. Apresentou boa resposta ao tratamento com metotrexato em baixas doses semanais. Abstract in english Primary cutaneous anaplastic large-cell lymphoma is part of the spectrum of CD30+ lymphoproliferative cutaneous processes, characterized by single or multifocal nodules that ulcerate, are autoregressive and recurrent. Extracutaneous dissemination may occur, especially to regional lymph nodes. Histol [...] ogy shows a diffuse, non-epidermotropic infiltrate , anaplastic large lymphoid cells of immunohistochemistry CD30+, CD4+, EMA-/+, ALK-, CD15- and TIA1-/+. Prognosis is good and does not depend on lymphatic invasion. Radiotherapy, removal of the lesion and/or low-dose methotrexate are the treatments of choice. The present study reports the case of a 57-year-old-woman presenting Primary cutaneous anaplastic large-cell lymphoma with multifocal lesions. The pacient evolved with pulmonary involvement 7 years later. She showed a good response to the treatment with low-dose methotrexate prescribed weekly.

Luciana Silveira Rabello de, Oliveira; Madeleyne Palhano, Nobrega; Maira Gomes, Monteiro; Wagner Leite de, Almeida.

2013-12-01

358

A case of giant cavernous hemangioma of the liver complicated by intravascular coagulopathy.  

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Full Text Available A case of liver hemangioma complicated by intravascular coagulopathy is presented because of the rarity of the association. Hemangioma of the liver was suspected by palpation of the liver tumor, scintigraphy and x-ray examination, and confirmed by selective hepatic arteriography in combination with exploratory laparotomy. Intravascular coagulopathy was established by demonstrating secondary fibrinolysis and consumption of platelets and coagulation factors. Unconjugated hyperbilirubinemia due to micro-angiopathic hemolytic anemia was also present. The clinical course of the clotting abnormalities was basically a chronic one with an occasional acute or subacute defibrination process associated with further enlargement of the hepatic tumor. These provide sufficient evidence that the intravascular coagulopathy was closely related with the hemangioma in the liver. Neither ligation of a presumed nutritional artery of the hemangioma nor radiation therapy caused any demonstrable reduction in the tumor size.

Watanabe,Makoto

1978-04-01

359

Intravascular lymphoma associated with hemophagocytic syndrome: a rare but aggressive clinical entity.  

Science.gov (United States)

We report a 55-year-old male with a diagnosis of intravascular lymphoma and hemophagocytosis. He initially presented with hemolytic anemia and splenomegaly and was successfully treated with oral steroids. His clinical course was later complicated by fever, cytopenias, hypoalbuminemia, disseminated intravascular coagulation, gastrointestinal bleeding and acute tubular necrosis. Results of an extensive investigation for fever of unknown origin were negative. Although the patient was treated aggressively with antimicrobials, transfusion support and dialysis, he expired 3 weeks after hospitalization. Post-mortem analysis revealed large CD30- and CD45-positive lymphoma cells in an intravascular distribution in most of the organs studied. Histopathology of the spleen and bone marrow was significant for fulminant hemophagocytosis. PMID:14658009

Bhagwati, Niyati S; Oiseth, Stanley J; Abebe, Lool S; Wiernik, Peter H

2004-04-01

360

Imminent Cardiac Risk Assessment via Optical Intravascular Biochemical Analysis  

Energy Technology Data Exchange (ETDEWEB)

Heart disease is by far the biggest killer in the United States, and type II diabetes, which affects 8% of the U.S. population, is on the rise. In many cases, the acute coronary syndrome and/or sudden cardiac death occurs without warning. Atherosclerosis has known behavioral, genetic and dietary risk factors. However, our laboratory studies with animal models and human post-mortem tissue using FT-IR microspectroscopy reveal the chemical microstructure within arteries and in the arterial walls themselves. These include spectra obtained from the aortas of ApoE-/- knockout mice on sucrose and normal diets showing lipid deposition in the former case. Also pre-aneurysm chemical images of knockout mouse aorta walls, and spectra of plaque excised from a living human patient are shown for comparison. In keeping with the theme of the SPEC 2008 conference Spectroscopic Diagnosis of Disease this paper describes the background and potential value of a new catheter-based system to provide in vivo biochemical analysis of plaque in human coronary arteries. We report the following: (1) results of FT-IR microspectroscopy on animal models of vascular disease to illustrate the localized chemical distinctions between pathological and normal tissue, (2) current diagnostic techniques used for risk assessment of patients with potential unstable coronary syndromes, and (3) the advantages and limitations of each of these techniques illustrated with patent care histories, related in the first person, by the physician coauthors. Note that the physician comments clarify the contribution of each diagnostic technique to imminent cardiac risk assessment in a clinical setting, leading to the appreciation of what localized intravascular chemical analysis can contribute as an add-on diagnostic tool. The quality of medical imaging has improved dramatically since the turn of the century. Among clinical non-invasive diagnostic tools, laboratory tests of body fluids, EKG, and physical examination are still the first line of defense. However, with the fidelity of 64-slice CT imaging, this technique has recently become an option when the patient presents with symptoms of reduced arterial flow. Single photon emission computerized tomography (SPECT) treadmill exercise testing is a standard non-invasive test for decreased perfusion of heart muscle, but is time consuming and not suited for emergent evaluation. Once the invasive clinical option of catherization is chosen, this provides the opportunity for intravascular ultrasound (IVUS) imaging. As the probe is pulled through the artery, the diameter at different parts is measurable, and monochrome contrast in the constricted area reveals the presence of tissue with a different ultrasonic response. Also, via an optical catheter with a fiber-optic conductor, the possibly of spectroscopic analysis of arterial walls is now a reality. In this case, the optical transducer is coupled to a near-infrared spectrometer. Revealing the arterial chemical health means that plaque vulnerability and imminent risk could be assessed by the physician. The classical emergency use of catherization involves a contrast agent and dynamic X-ray imaging to locate the constriction, determine its severity, and possibly perform angioplasty, and stent placement.

Wetzel, D.; Wetzel, L; Wetzel, M; Lodder, R

2009-01-01

361

Protection against high intravascular pressure in giraffe legs  

DEFF Research Database (Denmark)

The high blood pressure in giraffe leg arteries renders giraffes vulnerable to edema. We investigated in 11 giraffes whether large and small arteries in the legs and the tight fascia protect leg capillaries. Ultrasound imaging of foreleg arteries in anesthetized giraffes and ex vivo examination revealed abrupt thickening of the arterial wall and a reduction of its internal diameter just below the elbow. At and distal to this narrowing, the artery constricted spontaneously and in response to norepinephrine and intravascular pressure recordings revealed a dynamic, viscous pressure drop along the artery. Histology of the isolated median artery confirmed dense sympathetic innervation at the narrowing. Structure and contractility of small arteries from muscular beds in the leg and neck were compared. The arteries from the legs demonstrated an increased media thickness-to-lumen diameter ratio, increased media volume, and increased numbers of smooth muscle cells per segment length and furthermore, they contracted more strongly than arteries from the neck (500 ± 49 vs. 318 ± 43 mmHg; n = 6 legs and neck, respectively). Finally, the transient increase in interstitial fluid pressure following injection of saline was 5.5 ± 1.7 times larger (n = 8) in the leg than in the neck. We conclude that 1) tissue compliance in the legs is low; 2) large arteries of the legs function as resistance arteries; and 3) structural adaptation of small muscle arteries allows them to develop an extraordinary tension. All three findings can contribute to protection of the capillaries in giraffe legs from a high arterial pressure.

Petersen, Karin K; HØrlyck, Arne

2013-01-01

362

Possible role of intravascular coagulation in radiation nephritis  

International Nuclear Information System (INIS)

Thrombosis contributes to pathogenic mechanisms of such late effects as organ fibrosis and premature atherosclerosis. Recently deposition of fibrin in kidney glomeruli was postulated to be of possible significance for radiation nephritis. Results of the following studies support this view. A generalized Schwartzman reaction was provoked in 24 rabbits by a single dose of 50 ?g of endotoxin (Salmonella enteritidis, Lipopolysaccharide B, Difco) administered 24 h after whole-body exposure to 850 R of X-rays. This procedure induced similar laboratory signs of intravascular coagulation and somewhat more pronounced fibrin deposition in kidneys compared with a group (28 rabbits) treated in a classical manner, i.e. with two doses of endotoxin spaced by a 24 h interval. In about two-thirds of 29 patients with uterine carcinoma, fibrin degradation products (FDP) appeared in urine during treatment with radium and 60Co. Since kidneys were exposed to only negligible doses of radiation under the applied conditions of therapy, experiments in dogs were performed aimed at elucidating the significance of direct renal exposure. Fractionated doses (19 x 400 R, 5 weeks) of X-rays were given to either the kidney or mediastinum region. Irradiation resulted in a pronounced increase in serum FDP and the appearance of FDP in the urine. The character and dynamics of changes were similar in both groups regardless of whether kidneys or mediastinum were exposed. Results of other coagulaum were exposed. Results of other coagulation tests and histological examinations indicate that radiation induces systemic activation of blood coagulation and renal deposition of fibrin. Kidneys can be involved in this process in an indirect way. (author)

363

Dose effect of guidewire position in intravascular brachytherapy  

International Nuclear Information System (INIS)

It has been reported that the dose effects of metallic guidewires are significant in intravascular brachytherapy (IVBT) using a beta source. The purpose of this work is to investigate the dependence of these dose effects on guidewire position. The EGS4 Monte Carlo codes were used to perform the dose calculations for the 90Sr (NOVOSTE), 32P (Guidant) and 192Ir (BEST Ind.) sources with and without a guidewire in place. Guidewires were placed at various distances from the central axes of the sources. Due to the attenuation by the guidewires, a dose reduction of up to 70% behind a guidewire was observed for the beta sources, while the dose perturbation was found to be negligible for the gamma source. The dose reduction for the beta sources was found to be dependent on the guidewire location. For example, the dose reduction was 10% higher for a stainless steel guidewire located at 0.5 mm than that for the guidewire at 2 mm from the central axis of the source. The portion of the target volume affected (shadowed) dosimetrically by the guidewire was reduced when the guidewire was positioned farther away from the source. The shadow volume (in which the dose reduction occurs) can be reduced by up to 45% as the guidewire is moved away from the source axis from 0.5 mm to 2 mm. The dosimetric perturbations due to the presence of a metallic guidewire as well as their dependence on guidewire location should be considered in designing a new IVBT delive considered in designing a new IVBT delivery device, in analysing the treatment efficacy, and/or in dose prescription for a beta source. (author)

364

IVBTMC, A Monte Carlo dose calculation tool for intravascular brachytherapy  

International Nuclear Information System (INIS)

A new Monte Carlo code (IVBTMC) is developed for accurate dose calculations in intravascular brachytherapy (IVBT). IVBTMC calculates the dose distribution of a brachytherapy source with arbitrary size and curvature in a general three-dimensional heterogeneous medium. Both beta and gamma sources are considered. IVBTMC is based on a modified version of the EGSNRC code. A voxel-based geometry is used to describe the target medium incorporating heterogeneities with arbitrary composition and shape. The source term is modeled using appropriate phase-space data. The phase-space data are calculated for three widely used sources (32P, 90Sr/90Y, and 192Ir). To speed up dose calculations for gamma sources, a special version of IVBTMC based on the kerma approximation is developed. The accuracy of the phase-space data model is verified and