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Sample records for linfoma intravascular tratado

  1. COMPROMISO SISTÉMICO POR LINFOMA INTRAVASCULAR DE CÉLULA GRANDE COMPROMISSO SISTÉMICO POR LINFOMA INTRAVASCULAR DE CÉLULA GRANDE SYSTEMIC COMPROMISE FROM LARGE CELL INTRAVASCULAR LYMPHOMA

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    JOSÉ J. ARIAS A.

    2008-07-01

    Full Text Available Se presenta el primer caso de linfoma intravascular de célula grande, una variante del linfoma de células B grandes difuso, diagnosticado en el Hospital Militar Central de Bogotá, en una mujer adulta mayor, quien consultó por un síndrome febril prolongado, pérdida de peso, síntomas constitucionales y quien veinte días antes del ingreso perdió fuerza progresiva, hasta la paraplejia. Se iniciaron estudios para descartar enfermedades neoplásicas, infecciosas y autoinmunes, pero falleció el día catorce de su hospitalización. El estudio post-mortem, realizado cinco horas después, mostró una lesión tumoral maligna de célula grande, limitada a los espacios vasculares de múltiples vísceras. Se planteó como diagnóstico una neoplasia de origen linfoide, que se confirmó posteriormente mediante pruebas inmunohistoquímicas.Apresenta-se o primeiro caso de linfoma intravascular de célula grande, uma variante do linfoma de células B grandes difuso, diagnosticado no Hospital Militar Central de Bogotá, numa mulher adulta maior, quem conferiu por uma síndrome febril prolongado, perda de peso, sintomas constitucionais e quem vinte dias antes do rendimento perdeu força progressiva, até a paraplegia. Iniciaram-se estudos para descartar doenças neoplásicas, infecciosas e auto-imunes, mas faleceu o dia quatorze de sua hospitalização. O estudo post-mortem, realizado cinco horas depois, mostrou uma lesão tumoral maligna de célula grande, limitada aos espaços vasculares de múltiples vísceras. Propôs-se como diagnóstico uma neoplasia de origem linfóide, que se confirmou posteriormente mediante provas inmunohistoquímicas.This is the first case of intravascular large cell lymphoma diagnosed at the Hospital Militar de Bogota, in an adult female who presented with chronic fever, weight loss, constitutional symptoms and progressive motor deterioration for the previous 20 days to the point of paraplegia. A work up was carried out to rule out neoplastic diseases, infections or autoimmune diseases, but she died on the fourteen hospital day. The autopsy, performed 5 hours post mortem, showed an intravascular large cell malignancy, limited to the vascular spaces of multiple organs. The lymphomatous origin was confirmed posteriorly by immunochemical tests.

  2. Linfoma intravascular, un desafio diagnóstico: Caso clínico

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    Pablo Young

    2015-08-01

    Full Text Available Intravascular lymphoma is a rare subtype of extranodal diffuse large B-cell lymphoma characterized by clonal proliferation of lymphocytes inside of small and medium caliber vessels. Its incidence is estimated at one case per million. The clinical picture is very variable, but frequently has skin and central nervous system involvement. It is diagnosed by demonstrating pathological blood vessel infiltration by lymphoma cells. We report a 44 years old male presenting with fever, malaise and erythematous lesions in the abdominal wall. An abdominal wall biopsy showed dilated vascular vessels with atypical cells in their lumen, compatible with large B-cell intravascular lymphoma. He was treated with rituximab, cyclophosphamide, adriamycin, vincristine and prednisone and an autologous hematopoietic stem cell transplantation, achieving a complete remission that has lasted two years.

  3. Linfoma no Hodgkin secundario a inmunosupresión por transplate renal tratado con quimioterapia

    Scientific Electronic Library Online (English)

    Ámbar, Guzmán; Hugo, Ruíz; Oneida, Parra; Carmen, Umbría; Angelo, Garofalo; Luisa, González; Karen, Kubicek.

    2011-03-01

    Full Text Available OBJETIVO: Los síndromes linfoproliferativos posterior a trasplante renal incluyen un grupo de enfermedades linfoides que por definición se presentan después del mismo en un órgano sólido o en la médula ósea y están en relación con la terapia inmunosupresora administrada. La probabilidad de desarroll [...] ar una neoplasia maligna en un receptor de trasplante renal seguido a lo largo de 17 años, es de un 14 % para cánceres no cutáneos, de un 47 % en los carcinomas de piel y un 55 % para cualquier tipo de cáncer. MÉTODO: En este trabajo se describe un caso poco común de un paciente de 40 años con insuficiencia renal crónica secundario a hipertensión arterial en hemodiálisis, quien se le realizó trasplante renal de cadáver en el 2007, presentando alteración de función renal con masa palpable en fosa ilíaca derecha, en tratamiento con inmunosupresores. RESULTADOS: El examen histopatológico de la biopsia reportó: desorden linfoproliferativo posterior a trasplante con inmunohistoquímica positivo para CD20, CD79 en células linfoides B y CD45 en células linfoides T. Estudios de extensión metástasis en mediastino concluyéndose como: linfoma no Hodgkin inmunofenotipo B CD20+ estadio IV extra nodal renal con metástasis en mediastino superior mayo/2009 IPI score alto riesgo secundario a trasplante renal. Recibió tratamiento con R-CHOP obteniéndose respuesta oncológica completa, demostrado por CT-PET, actualmente libre de enfermedad, en controles nefrológicos. CONCLUSIÓN: Se debe vigilar cualquier alteración clínica, ya que un rechazo de trasplante se puede confundir con una patología oncológica. Abstract in english OBJECTIVE: The posterior transplant lymph syndrome proliferative disorders include a group of renal lymphoid diseases by definition are present after a solid organ transplant or in bone marrow and are related to immunosuppressive therapy administered. The likelihood of developing a malignancy renal [...] transplant recipient followed over the 17 years is 14 % for the non-skin cancers, 47 % in the carcinomas of the skin and 55 % for any type of cancer. METHOD: In this work we describes a rare case of a 40 year old patient with chronic renal failure secondary to arterial hypertension in hemodialysis, who underwent cadaveric renal transplant in 2007, the patient presented impaired renal function with palpable mass in right iliac fosse, in treatment with immune suppressants. RESULTS: The histopathology examination of the biopsy reported, posterior transplant with lymphoproliferative disorder with immunohistochemistry positive for CD20, CD79 on B lymphoid cells and CD45 on T lymphoid cells, the extension studies concluding that the mediastinal metastases were: Non-Hodgkin’s lymphoma immunophenotyping B extranodal CD20 + stage IV renal with metastases in the superior mediastinum IPI score May/2009 classified how secondary to high risk renal transplantation. The patient was treated with R-CHOP we obtained a oncology complete response, as demonstrated by CT-PET, and currently free of disease, in nephrology controls. CONCLUSION: It should monitor any clinical manifestation in the treatment of this kind of patients and served as a rejection of transplant can be confused with metastatic brain tumor.

  4. High grade primary adrenal intravascular large B-cell lymphoma manifesting as Addison disease Linfoma intravascular de alto grado de células B grandes y origen suprarrenal que se manifiesta en forma de enfermedad de Addison

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    J. Venizelos

    2007-08-01

    Full Text Available We report a rare case of a 68 aged male who presented with adrenal failure and was diagnosed of high grade large B-cell lymphoma primarily arising in the adrenal glands. The patient was administrated with additional chemotherapy but he passed away 7 months later due to infection in the lungs. Intravascular lymphoma should be suspected in patients with bilateral adrenal masses who present with rapidly progressive adrenal insufficiency.Publicamos el caso poco frecuente de un varón de 68 años de edad que debutó con insuficiencia adrenal y fue diagnosticado de linfoma de alto grado de células B grandes ubicado principalmente en las glándulas suprarrenales. Al paciente le administraron quimioterapia adicional, pero falleció 7 meses después de infección pulmonar. El linfoma intravascular debe sospecharse en los pacientes con masas suprarrenales bilaterales que presenten insuficiencia adrenal rápidamente progresiva.

  5. Primary lymphoma of the liver treated by extended hepatectomy and chemotherapy: a case report Linfoma primário do fígado tratado por hepatectomia ampliada e quimioterapia: relato de caso

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    Eleazar Chaib

    2002-09-01

    Full Text Available Primary lymphoma of the liver is an extremely rare entity. A case of anaplastic large B-cell (both CD-20 and lambda positive non-Hodgkin's lymphoma that was confined to the liver in a 33-year-old man is reported. The patient was treated with an extended right hepatectomy and combination chemotherapy: cyclophosphamide, adriamycin, vincristine, and prednisone. The patient was disease free 24 months after the procedure.O linfoma primário do fígado é uma entidade extremamente rara. Os autores relatam um caso de linfoma não-Hodgkin de células B grandes anaplásicas (positivo para CD-20 e Lambda em um paciente do sexo masculino de 33 anos. O tumor estava localizado no lobo hepático direito e foi tratado por hepatectomia direita ampliada e quimioterapia pós-operatória com ciclofosfamida, adriamicina, vincristina e prednisone. Vinte quatro meses de seguimento o paciente encontra-se sem recidiva tumoral.

  6. Linfoma Gástrico Primario

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    Fernando Barreda B

    2004-07-01

    Full Text Available Introducción: El Linfoma Gástrico Primario es una entidad infrecuente dentro de las neoplasias que afectan el estómago. La histología del Linfoma Gástrico Primario es variada y adquiere connotación especial el Linfoma a células B de la zona marginal extranodal, por su potencial remisión con la antibioticoterapia. Objetivos: Apreciar las características clínicas de los pacientes con Linfoma Gástrico Primario, los hallazgos endoscópicos más relevantes, identificar los factores que influencian la supervivencia y evaluar los efectos de la terapia. Material y métodos: El presente estudio es de tipo observacional, analítico y de corte transversal, se realizó en 169 pacientes con diagnóstico histológico de Linfoma Gástrico que fueron atendidos en el Instituto Especializado de Enfermedades Neoplásicas, Lima-Perú, desde Enero de 1995 a Diciembre del 2000. Para el estadiaje se utilizó el sistema Ann Arbor modificado por Musshoff y la histología de acuerdo a la clasificación REAL-WHO. El análisis estadístico incluyó el t de student y el chi cuadrado. La supervivencia fue consignada con las curvas de Kaplan Meier y los factores pronóstico con el test de regresión de Cox. Resultados: La muestra es representativa de pacientes de la Costa Peruana. La edad promedio es 55 años, con discreta predominancia del sexo femenino (54.4%. Los signos y síntomas son inespecíficos. El estadio clínico I-II corresponde al 75% de los pacientes. El patrón endoscópico de lesiones ulceradas múltiples es característico del Linfoma Gástrico. El 71% de los pacientes con Linfoma a células B de la zona marginal extranodal tuvieron remisión completa de la enfermedad con antibióticoterapia (5/7. El tipo histológico del Linfoma Gástrico en los 169 pacientes fue el siguiente: Linfoma a células B grande difuso 137 pacientes, Linfoma a células B de la zona marginal extra nodal 16 pacientes, Linfoma a células T periférico 6 pacientes, Linfoma a células grandes T anaplásico 3 pacientes, Linfoma no determinado 3 pacientes, Linfoma a células del manto 2 pacientes, Linfoma a células T del adulto 1 paciente y Linfoma folicular 1 paciente. La sobrevida global a 36 meses fue de 61.34%, la supervivencia de acuerdo al tipo histológico fue del 92.31% para Los Linfomas a células B de la zona marginal extranodal, del 62.21% para los Linfomas a células B grande difuso y del 29.63% para los Linfomas a células T. La sobrevida a 36 meses en pacientes con estadio clínico I-II que fueron tratados con quimioterapia fue del 82.16%, con cirugía fue del 71.89% y con cirugía más quimioterapia fue del 70.39%, mostrando los 3 grupos resultados semejantes (p: 0.6530. Los grupos catalogados de acuerdo al índice internacional, mostraron una clara diferencia entre ellos (p: 0.0000. El análisis univariado reveló que el Zubrod (p: 0.0000, el DHL (p: 0.0073, la remisión de la enfermedad (p: 0.0000, el estadio (p: 0.0000, el tratamiento (p: 0.0000, y la localización (p: 0.0000, tuvieron significancia estadística. El análisis multivariado mostró que en el modelo de regresión de Cox, la remisión (OR: 13.342, p: 0.0000, y la localización (OR: 2.375, p: 0.041, se encuentran dentro de la ecuación de dicha función. Conclusiones: Las lesiones ulceradas múltiples son características del Linfoma Gástrico. Se demuestra remisión de enfermedad en el Linfoma a células B de la zona marginal extranodal con antibioticoterapia (5/7. La quimioterapia en pacientes con EC I-II, alcanza resultados de supervivencia semejantes a la cirugía y a la combinación de ambas. Se confirma la validez del índice internacional y se demuestra en el análisis multivariado que la remisión y la localización de la enfermedad tienen significancia estadística.

  7. Transplante de células-tronco hematopoéticas em linfoma Hodgkin

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    Rosane I. Bittencourt; Laura Fogliato; Alessandra Paz; Mair P. Souza; Decio Lerner

    2010-01-01

    O linfoma Hodgkin(LH) é uma malignidade hematológica que conta com um armamentário terapêutico selecionado de acordo com o estadiamento e a classificação prognóstica de cada doente. A sobrevida dos pacientes tratados para o LH clássico vem aumentando significativamente, com taxas de cura entre 80%-85%. Entretanto, 20%-25% são refratários aos tratamentos iniciais e cerca de 30% recaem após ter alcançado resposta completa. Os pacientes considerados com falha à terapia de primeira linha ainda tê...

  8. Linfoma de Burkitt abdominal

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    José Ridal González Álvarez

    2014-04-01

    Full Text Available El linfoma de Burkitt es un tipo de linfoma no Hodgkin, infrecuente, que afecta principalmente a niños y adolescentes. Se presenta un adolescente masculino, blanco, de 12 años de edad y antecedentes de salud anterior, con un dolor en epigastrio, tipo cólico de pocos días de evolución, que fue incrementándose, sin modificaciones con la tos, estornudos o cambios de posición ni preferencia de horario, irradiado a fosa ilíaca derecha, sin vómitos, fiebre u otra sintomatología. Se realizan estudios imagenológicos, endoscópicos e histológicos, diagnosticándole un tumor de colon, es intervenido quirúrgicamente. El linfoma de Burkitt es una rara entidad que necesita de la clínica y la combinación de varios métodos de imagen para aproximarse a la sospecha diagnóstica y representa un gran desafío, por lo que alertamos a los pediatras a sospecharlo ante los dolores abdominales y tumoraciones de abdomen.

  9. Estudo prospectivo e randomizado de pacientes tratados com e sem stents revestidos com carbeto de silício amorfo para a prevenção da reestenose coronariana. Avaliação ultra-sonográfica Randomized intravascular ultrasound comparison between endoprostheses with and without amorphous silicon-carbide

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    Luiz Fernando Leite Tanajura

    2004-12-01

    Full Text Available OBJETIVO: A reestenose intra-stent é a maior limitação das intervenções coronárias percutâneas. O carbeto de silício amorfo (SiC-a, substância antitrombótica e antiinflamatória capaz de reduzir a deposição de fibrina, plaquetas e leucócitos sobre o stent, apresenta potencial de prevenir a hiperplasia neo-intimal e a reestenose. MÉTODOS: Estudo prospectivo, randomizado e tipo rótulo aberto comparando pacientes com doença coronariana tratados com e sem stents revestidos com o SiC-a, utilizando a angiografia quantitativa e o ultra-som intracoronário. Foram incluídos 100 pacientes (50 em cada grupo a fim de mensurar o volume de hiperplasia neo-intimal intra-stent/extremidades. Como os stents comparados apresentavam extensões diferentes, o volume de hiperplasia foi analisado em valores absolutos (por paciente e relativos (por milímetro de extensão do stent. Avaliaram-se ainda os eventos cardíacos maiores e os resultados da angiografia quantitativa. RESULTADOS: Os grupos apresentaram características de base semelhantes. Todos os pacientes foram tratados com sucesso. No 6° mês de evolução foram reestudados 94% dos casos dos dois grupos, obtendo-se ultra-som em 92%. O volume de hiperplasia neo-intimal absoluto foi significativamente maior nos tratados com os stents revestidos (51.2 DP 18.8 mm³ vs 41.9 DP 16.4 mm³; p=0.014, porém o relativo foi semelhante (2.9 DP 1.0 mm³/mm stent vs 2.5 DP 0.9 mm³/mm stent; p=0.108. A obstrução volumétrica da luz também foi similar (36.4 DP 11.1% vs 37.9 DP 10.9%; p=0.505. O diâmetro mínimo da luz (1.9 DP 0.7 mm vs 1.8 DO 0.6 mm; p=0.552, a reestenose (19.1% vs 17%; p>0.999 e a revascularização do vaso-alvo (16% vs 14%; p>0.999 não diferiram. CONCLUSÃO: Os stents revestidos apresentaram resultados clínicos, angiográficos e ultra-sonográficos similares aos controles.OBJECTIVE: In-stent restenosis remains a major limitation following coronary stent implantation. Amorphous silicon-carbide (a-SiC coating has been shown to improve stent biocompatibility, therefore, reducing local inflammation and thrombus generation. Due to the latter, a-SiC coating might have an impact on the prevention of neointimal hyperplasia (NIH and restenosis. METHODS: This prospective, randomized, open-label trial compared a-SiC-coated (group A versus uncoated (group B stent implantation in de novo lesions. We included 100 patients (50 patients in each group and the primary end-point was in-stent volume of NIH measured by intravascular ultrasound. RESULTS: All patients underwent successful stent deployment. Although absolute NIH volume was greater in A (51.2 mm³ SD 18.8 mm³ versus 41.9 mm³ SD 16.4 mm³; P = 0.014, relative (divided per mm of stent length NIH volume was similar (2.9 mm³/mm stent SD 1.0 mm³/mm stent versus 2.5 mm³/mm stent SD 0.9 mm³/mm stent; P = 0.108. Late loss, restenosis, and major adverse cardiac events (MACE were similar. CONCLUSION: A-SiC-coated stents did not reduce either NIH or MACE at long-term follow-up.

  10. Linfoma óseo primario

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    Onilda Labrada Silva

    2014-08-01

    Full Text Available El linfoma primario de hueso es definido histológicamente como un linfoma extra ganglionar, afecta los huesos y puede ser desarrollado por una enfermedad sistémica. Se presentó un caso de linfoma óseo primario en el Hospital General Docente “Ernesto Guevara de la Serna” de las Tunas en el año 2013, descrito como una forma muy rara de manifestación de los linfomas. Paciente masculino de 72 años de edad, con dolor a nivel del calcáneo derecho, inflamación e impotencia funcional. Se realizaron estudios imaginológicos que revelaron la existencia de osteoporosis y un tumor óseo primario de tipo linfomatoso

  11. Linfoma de Burkitt Burkitt lymphoma

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    Fernando Sierra Arego

    2012-03-01

    Full Text Available El linfoma de Burkitt es un tipo de linfoma no Hodgkin, no frecuente en Cuba, pues es endémico de África Central. Diagnosticar uno en nuestro país siempre es significativo, por lo que conocerlo es importante.The Burkitt lymphoma is a type of non-Hodgkin lymphoma infrequent in Cuba since it is endemic of Central Africa. The diagnosis of one in our country always is significant, thus it is important to know it.

  12. Intravascular ultrasound

    Science.gov (United States)

    IVUS; Ultrasound - coronary artery; Endovascular ultrasound; Intravascular echocardiography ... A tiny ultrasound wand is attached to the top of a thin tube called a catheter. This ultrasound catheter is inserted ...

  13. Disseminated Intravascular Coagulation

    Science.gov (United States)

    ... the NHLBI on Twitter. What Is Disseminated Intravascular Coagulation? Disseminated intravascular coagulation (ko-ag-u-LA-shun), or DIC, is ... vessel walls and stop bleeding. Clotting factors are proteins needed for normal blood clotting. With fewer platelets ...

  14. Linfoma de Burkitt oral: relato de caso Oral Burkitt's lymphoma: case report

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    Roseana de Almeida Freitas

    2008-06-01

    Full Text Available O linfoma de Burkitt é um raro e agressivo tipo de linfoma não-Hodgkin pobremente diferenciado. O presente relato trata de uma criança do sexo masculino, com sete anos de idade, que foi examinada na Clínica de Odontopediatria do Departamento de Odontologia da UFRN, exibindo uma massa tumoral na região de pré-molares mandibulares com mobilidade dentária. O exame radiográfico revelou uma área radiolúcida difusa e o diagnóstico histopatológico foi de linfoma de Burkitt. O paciente foi tratado por poliquimioterapia e obteve completa remissão da patologia.Burkitt's lymphoma is a poorly differentiated rare and aggressive type of non-Hodgkin's lymphoma. This article reports the case of a male child aged seven years, who was examined at the Odontopediatric Clinic of the UFRN Dentistry Department. The patient presented a tumor in the premolar region of the mandible; teeth were mobile in this region. Radiology revealed a diffuse radioluscent area which was diagnosed histopathologically as Burkitt's lymphoma. The patient was treated with polychemotherapy; complete remission of the disease was attained.

  15. Linfoma de ovario Ovarian lymphoma

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    Iván Bonet Fonseca

    2012-09-01

    Full Text Available Introducción: el 50 % de la patología oncológica en pediatría corresponde a masas o tumores sólidos, alrededor del 20 % del total se ubica en abdomen. Los tumores que se presentan con mayor frecuencia en el abdomen son el nefroblastoma o tumor de Wilms, el linfoma tipo Burkitt, el neuroblastoma y los tumores germinales de ovario. Objetivo: presentar un caso pediátrico con tumor abdominal. Caso clínico: se presenta un caso de una niña de 8 años de edad con antecedentes de salud aparente, atendida en el Hospital Público de la Universidad de Mbarara, Uganda. Resultado: paciente pediátrica que fue ingresada con una historia de 3 meses de dolor abdominal, pérdida ligera de peso y masa abdominal de crecimiento rápido, fue sometida a una laparotomía exploradora donde se resecó la masa tumoral, la que histológicamente arrojó ser un linfoma ovárico, como hallazgo durante la intervención quirúrgica se diagnosticó una agenesia de útero. Conclusión: la paciente se encuentra después del tratamiento con quimioterapia en seguimiento, lleva aparentemente hace 5 meses una vida normal (noviembre 2011.Introduction: 50 % of pediatric oncologic pathology corresponds to mass or solid tumors, reaching about 20 % of total abdomen. The tumors that most frequently occur in the abdomen are nephroblastoma or Wilms tumor, Burkitt's lymphoma, neuroblastoma, and ovarian germ cell tumors. Objective: to present a pediatric case with abdominal tumor. Case report: we report a case of an 8 year old girl with a history of apparent good health. This patient was assisted the Public Hospital of Mbarara University, Uganda. Result: a female pediatric patient was admitted with a 3-month history of abdominal pain, mild weight loss, and rapid growth of an abdominal mass. This patient underwent an exploratory laparotomy where the tumor mass was removed. It was histologically confirmed as an ovarian lymphoma. It was diagnosed uterus agenesis. Conclusion: after chemotherapy, the patient is controlled, and she has an apparently normal life for already 5 months (November 2011.

  16. Linfoma nasal de células T asesinas naturales

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    MARÍA CLAUDIA CHAVARRIAGA

    2011-01-01

    Full Text Available El linfoma nasal de células T asesinas naturales, también conocido como granuloma letal de la línea media, es una entidad poco frecuente. Se trata de un linfoma extraganglionar de comportamiento agresivo que, usualmente, se origina en la cavidad nasal, prevalente en países orientales y en hombres en la tercera década de la vida. Su asociación con infección por el virus de Epstein-Barr actualmente está bien documentada. Su tratamiento es aún controvertido; la tendencia actual está a favor de la radioterapia. A continuación se presenta un caso de linfoma nasal de células T asesinas naturales y la revisión de la literatura, con el fin de proveer un mayor entendimiento de la enfermedad.

  17. Linfoma MALT en diferentes localizaciones MALT lymphoma in different locations

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    Ana Dolores Izquierdo Calzado

    2012-03-01

    Full Text Available Se describen 3 casos de pacientes con linfoma MALT, diagnosticados, tratados y seguidos en la consulta de hematología del Hospital Provincial Docente Clinicoquirúrgico "Saturnino Lora" de Santiago de Cuba, a la cual fueron remitidos por gastroenterólogos, otorrinolaringólogos y maxilofaciales de la mencionada institución. Uno de los afectados presentaba una masa tumoral gástrica y en nasofaringe, aparecida en diferentes momentos; otro un tumor linfoide en el paladar duro, que recurrió en ganglios infradiafragmáticos; y un tercero un nódulo linfoide en la glándula salival parótida unilateral, con recidiva en ganglios regionales después de haber sido extirpado. Todos experimentaron una buena respuesta clínica al inicio del tratamiento convencional, pero en 2 de ellos se confirmaron reapariciones no locales del proceso morboso.Three cases of patients with MALT lymphoma are described, who were diagnosed, treated and followed up at the hematology department of "Saturnino Lora" Teaching Provincial Hospital in Santiago de Cuba, to which they were referred by gastroenterologists, otolaryngologists and maxillofacial specialists of that institution. One of those patients presented with a nasopharyngeal and gastric mass, which appeared at different times; another patient had lymphoid tumor of the hard palate, which recurred in infradiaphragmatic lymph nodes; and a third one had a lymphoid node in the unilateral salivary parotid gland with recurrence in regional nodes after having been removed. All experienced a good clinical response at the beginning of conventional treatment, but in 2 of them non-local recurrences of the disease process were confirmed.

  18. Amiloidosis sistémica y linfoma no Hodgkin

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    Daniel V. Drake Sosa

    2014-08-01

    Full Text Available La amiloidosis sistémica se caracteriza por el depósito extracelular de proteína amiloide en uno o más órganos. Se presenta el caso de un hombre de 62 años de edad, con antecedentes de lesiones papulosas, amarillentas y brillantes, fundamentalmente en el tronco y las extremidades; con formación de placas profundas y dolorosas de más de un año de evolución, así como lesiones papulosas purpúricas en el abdomen y muslos. El paciente también refirió dolores abdominales y articulares. Los exámenes complementarios demostraron anemia, una eritrosedimentación acelerada, eosinofilia y trastornos de la función hepática. El ultrasonido abdominal informó hepatomegalia, mientras que el medulograma reveló una médula ósea infiltrada por linfocitos pequeños, con depresión del sistema eritropoyético y ligero aumento de mielocitos eosinófilos del sistema granulopoyético, sugestivos de un Linfoma No Hodgking. La biopsia cutánea demostró el depósito de sustancia amiloide en la dermis superior y en las paredes vasculares. El paciente fue tratado con prednisona y ciclofosfamida, obteniéndose una mejoría de su cuadro clínico

  19. tratados internacionales en Colombia

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    Hernán Alejandro Olano García

    2006-01-01

    Full Text Available El autor presenta un trabajo con los aspectos más destacados de la jurisprudencia de la Corte Constitucional colombiana en torno al control jurisdiccional de constitucionalidad de los tratados públicos internacionales, la cual es previa al canje de instrumentos de ratificación, automática, puesto que en caso de no enviarse a la Corte ésta conoce directamente, ya que el control comprende la revisión constitucional del tratado y de su ley aprobatoria.

  20. Instantánea del linfoma

    Science.gov (United States)

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el linfoma; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  1. Linfoma esplénico de la zona marginal

    OpenAIRE

    Ariel Bello; Fernando De La Vega; Katherine Redondo; Karina Riuz; Liney Mendoza; Mario Lora

    2015-01-01

    Los linfomas no Hodgkin son un grupo de neoplasias que afectan los ganglios linfáticos y/o el tejido linfoide extraganglionar. Su frecuencia ha ido en ascenso en los últimos años. Según la clasificación de la OMS para los linfomas no Hodgkin, los linfomas esplénicos de la zona marginal (LEZM) son neoplasias de las células B maduras que constituyen menos de 2% de todos estos tipos de linfomas. Se presenta el caso de un paciente de 58 años, quien consultó por presentar fiebre prolongada, asocia...

  2. Intravascular malignant lymphomatosis

    International Nuclear Information System (INIS)

    Intravascular malignant lymphomatosis is a rare and probably often overlooked disease characterised by massive intravascular proliferation of lymphoid cells, usually with a poor prognosis. CT and MRI appearances are nonspecific; the most suggestive finding being both asymmetrical, bilateral, contrast enhancing high-signal areas on T2 weighting and infarct-like lesions of the cortex and basal ganglia. We report two patients with previously unreported dural and spinal cord involvement. (orig.)

  3. Linfoma no Hodgkin fulminante presentándose con acidosis láctica e insuficiencia hepática aguda: reporte de caso y revisión de la literatura

    Directory of Open Access Journals (Sweden)

    Guillermo Flores Padilla

    2009-01-01

    Full Text Available La falla hepática causada por neoplasias malignas es rara. Puede ser secundaria a cáncer hepatocelular, metástasis hepáticas, neoplasias secundarias o como complicación de agentes quimioterapéuticos. Las neoplasias hematológicas, como la leucemia, linfoma no Hodgkin y linfoma Hodgkin generalmente no causan falla hepática y más raramente aún producen falla hepática aguda fulminante. Caso clínico: se presenta un hombre de 43 años de edad con diarrea, náuseas y dolor abdominal leve de dos semanas de evolución. Fue tratado con antibióticos orales sin mejoría. Ingresó con falla hepática al departamento de urgencias en donde se lo encontró ictérico, agitado, taquicárdico e hipotenso. Tenía equimosis alrededor de los ojos y tórax, sangrado activo en sitios de venopunción y hematuria macroscópica. El abdomen estaba doloroso con hepatomegalia. Los estudios de laboratorio tenían hallazgos que correspondían a falla hepatorrenal aguda, serología para hepatitis viral negativa, anticuerpos antinucleares negativos y el panel de hierro normal. El ultrasonido abdominal mostró hepatoesplenomegalia. El paciente desarrolló hipoglucemia refractaria y mayor aumento de ácido láctico sérico. Falleció a los cinco días de su admisión. Conclusiones: la falla hepática aguda como presentación inicial de linfoma es rara. Esto puede retrasar el diagnóstico, contribuyendo al mal pronóstico de esta entidad. Establecer el diagnóstico de malignidad como causa de falla hepática aguda es difícil y requiere un alto índice de sospecha. Dado el mal pronóstico asociado con el diagnóstico tardío y los potenciales beneficios de la quimioterapia, se debe considerar al linfoma como causa de falla hepática aguda sin una etiología evidente y asociado a acidosis láctica y hepatomegalia.

  4. Asociación de linfomas malignos con herpes virus I y II

    Directory of Open Access Journals (Sweden)

    Ashley Efraín Alarcon-Rozas

    2002-04-01

    Full Text Available Objetivos: Conocer la prevalencia de la seropositividad para herpes virus I y II en pacientes con linfomas non Hodgkin y su asociación con el linaje celular (B ó T. Pacientes y métodos: Se tomó una muestra de 60 pacientes en el Hospital Almenara de agosto de 1999 a diciembre del 2000 todos ellos pacientes con diagnostico establecido de linfoma non Hodgkin nuevos o en primera recaída, el análisis se realizó mediante bioestadística descriptiva. Resultados: La mediana de la edad fue de 59 años, 2/3 fueron varones, 65% pacientes nuevos y el linfoma primario fue extraganglionar en un 58% de los casos. El 80% de los linfomas fueron a células B y mas del 90% en estadios avanzados (III y IV, ningún caso fue positivo para IgM herpes I o II y 25% tuvieron serología positiva IgG para herpes I o II (2/3 positivos para IgG I de los cuales el 93% fueron a células B. Conclusiones: La prevalencia de seropositividad para herpes virus I y II en pacientes con linfoma non Hodgkin es del 25%, mayormente asociado a células B, además de tener un porcentaje considerable de linfomas a células T (25% y linfomas extranodales (58%; para evaluar la posibilidad de asociación entre este virus y los linfomas requerimos de un estudio caso-control.

  5. Linfoma do sistema nervoso central: ensaio iconográfico

    Directory of Open Access Journals (Sweden)

    Fabiano Reis

    2013-04-01

    Full Text Available Ilustramos este ensaio iconográfico de linfoma do sistema nervoso central com imagens de ressonância magnética obtidas em nosso serviço nos últimos 13 anos e discutimos algumas das principais características radiológicas deste tipo de linfoma, primário e secundário. O linfoma sistema nervoso central é um tumor relativamente infrequente, mas alguns achados na ressonância magnética podem sugerir este diagnóstico.

  6. Linfoma hepático primario: Evolución favorable con quimioterapia combinada con rituximab Primary hepatic lymphoma: favorable outcome with chemotherapy plus rituximab

    Directory of Open Access Journals (Sweden)

    I. Serrano-Navarro

    2008-11-01

    Full Text Available Comunicamos el caso de una paciente con un linfoma hepático primario tratado con éxito con quimioterapia combinada con rituximab. Utilizando los "encabezamientos estándar para búsquedas bibliográficas informatizadas" (Medical Subject Heading revisamos los casos publicados hasta la fecha de esta infrecuente entidad.This article describes the case of a patient with a non-Hodgkin primary hepatic lymphoma who was successfully treated with chemotherapy combined with rituximab. Using the Medical Subject Headings the published reports of this rare entity were reviewed.

  7. Comprometimento medular por linfoma tipo Burkitt: relato de um caso

    OpenAIRE

    Murillo Côrtes Drummond; Sueli Alves de Andrade; Manoel de Almeida Moreira Filho; Vera Regina Lobo Magalhães

    1985-01-01

    Registro de caso de linfoma tipo Burkitt com comprometimento intrarraqueano em criança de três anos de idade. Considerações sobre esse tipo de tumor são feitas em função do caso observado e de dados da literatura.

  8. Harmonic Intravascular Ultrasound

    OpenAIRE

    Frijlink, Martijn

    2006-01-01

    textabstractMedical ultrasound is a popular imaging modality in cardiology. Harmonic Imaging is a technique that has been shown to increase the image quality of diagnostic ultrasound at frequencies below 10 MHz. However, Intravascular Ultrasound, which is a technique to acoustically investigate arteries from within the lumen by means of a catheter, typically transmits at higher ultrasound frequencies ( >20 MHz). This dissertation describes studies showing the feasibility and potential of Harm...

  9. Intravascular lesions of the hand

    Directory of Open Access Journals (Sweden)

    Duke Wayne H

    2008-05-01

    Full Text Available Abstract Introduction Intravascular lesions of the hand comprise reactive and neoplastic entities. The clinical diagnosis of such lesions is often difficult, and usually requires pathologic examination. We present the largest series to date of intravascular lesions affecting the hand. Methods A retrospective review of intravascular (arterial and venous lesions involving the hand was conducted. Data regarding clinicopathologic findings were analyzed. Results We identified 10 patients with intravascular lesions of their hands including thromboemboli (n = 3, reactive intravascular conditions such as papillary endothelial hyperplasia or Masson's tumor (n = 2 and fasciitis (n = 1, as well as vascular neoplasms including pyogenic granuloma (n = 2 and angioleiomyoma (n = 2. Conclusion Blood vessel injury and/or venous thrombosis may predispose to several intravascular lesions of the hand. Recognition of reactive entities from neoplastic conditions is important.

  10. Intravascular "mulberry-like" bodies

    DEFF Research Database (Denmark)

    Sørensen, Flemming Brandt; Klebe, J G; Henriques, U V

    1988-01-01

    Intravascular "mulberry-like" bodies in a stillborn female infant with moderate maceration are reported. The histogenesis of these structures is discussed based on light-microscopic, immunohistochemical and ultrastructural findings. No demonstrable causal relation between the intravascular lesions...... and fetal death was found, the cause of death being attributed to intrauterine asphyxia. It is concluded, that intravascular "mulberry-bodies" most likely represent artifacts due to red blood cell autolysis....

  11. Mucormicosis yeyunal en paciente con linfoma de Hodgkin Jejunal mucormycosis in a patient with Hodgkin's lymphoma

    Directory of Open Access Journals (Sweden)

    B. Madrigal

    2008-08-01

    Full Text Available Comunicamos un caso de mucormicosis intestinal en un hombre de 46 años de edad, diagnosticado de enfermedad de Hodgkin clásica, estadio IV-B. Durante la primera fase de la quimioterapia, sufrió una hemorragia digestiva masiva secundaria a una úlcera yeyunal por zigomicosis tipo mucor, diagnosticada por biopsia endoscópica. El paciente fue tratado con antifúngicos y resección quirúrgica del intestino afectado. En la cirugía, se apreció una doble perforación yeyunal cubierta. El estudio anatomopatológico de la pieza confirmó el diagnóstico previo. Tras un año de seguimiento, el paciente está recuperado y su linfoma de Hodgkin en remisión completa. Tras una extensa revisión de la literatura, según nuestro conocimiento, este es el segundo caso publicado en la literatura de mucormicosis intestinal en un paciente con linfoma de Hodgkin.We report a case of intestinal mucormycosis in a 46-year-old male diagnosed with classical Hodgkin's disease, IV-B stage. During the first phase of chemotherapy he had a massive digestive bleeding event secondary to a jejunal ulcer, and zygomicosis mucor-type was diagnosed by endoscopic biopsy. The patient was treated with antifungal drugs and surgical resection of the intestine involved. At surgery a double covered perforation of the jejunum was seen. Pathological examination confirmed the previous diagnosis. After one year of follow-up the patient is doing well, and his lymphoma is on remission. To our best knowledge this is the second case of intestinal mucormycosis in a patient with Hodgkin's lymphoma reported in the medical literature.

  12. How Is Disseminated Intravascular Coagulation Treated?

    Science.gov (United States)

    ... the NHLBI on Twitter. How Is Disseminated Intravascular Coagulation Treated? Treatment for disseminated intravascular coagulation (DIC) depends ... and treat the underlying cause. Acute Disseminated Intravascular Coagulation People who have acute DIC may have severe ...

  13. Linfoma esplénico de la zona marginal

    Directory of Open Access Journals (Sweden)

    Ariel Bello

    2015-01-01

    Full Text Available Los linfomas no Hodgkin son un grupo de neoplasias que afectan los ganglios linfáticos y/o el tejido linfoide extraganglionar. Su frecuencia ha ido en ascenso en los últimos años. Según la clasificación de la OMS para los linfomas no Hodgkin, los linfomas esplénicos de la zona marginal (LEZM son neoplasias de las células B maduras que constituyen menos de 2% de todos estos tipos de linfomas. Se presenta el caso de un paciente de 58 años, quien consultó por presentar fiebre prolongada, asociado a pérdida de peso, pancitopenia y esplenomegalia masiva no dolorosa. Después de realizar múltiples estudios, los cuales resultaron negativos, se decide realizar esplenectomía diagnóstica y terapéutica. Se obtiene en resultado de histología resultado compatible con linfoma esplénico de la zona marginal. Posteriormente, paciente presenta mejoría exitosa de todos sus síntomas y es dado de alta del hospital. (Acta Med Colomb 2015; 40: 62-65.

  14. Linfoma de Burkitt en un portador de granulomatosis de Wegener

    Directory of Open Access Journals (Sweden)

    Kryssia Rodríguez-Castro

    2005-10-01

    Full Text Available Se reporta el caso de un paciente costarricense portador de granulomatosis de Wegener, en tratamiento con ciclofosfamida y prednisona, quien desarrolla un linfoma de Burkitt que lo lleva a la muerte. Se menciona la posible relación entre estas dos patologías.

  15. Comprometimento medular por linfoma tipo Burkitt: relato de um caso

    Directory of Open Access Journals (Sweden)

    Murillo Côrtes Drummond

    1985-06-01

    Full Text Available Registro de caso de linfoma tipo Burkitt com comprometimento intrarraqueano em criança de três anos de idade. Considerações sobre esse tipo de tumor são feitas em função do caso observado e de dados da literatura.

  16. Dosimetry in intravascular brachytherapy

    International Nuclear Information System (INIS)

    Among the cardiovascular diseases responsible for deaths in the adult population in almost all countries of the world, the most common is acute myocardial infarction, which generally occurs because of the occlusion of one or more coronary arteries. Several diagnostic techniques and therapies are being tested for the treatment of coronary artery disease. Balloon angioplasty has been a popular treatment which is less invasive than traditional surgeries involving revascularization of the myocardium, thus promising a better quality of life for patients. Unfortunately, the rate of restenosis (re-closing of the vessel) after balloon angioplasty is high (approximately 30-50% within the first year after treatment).Recently, the idea of delivering high radiation doses to coronary arteries to avoid or delay restenosis has been suggested. Known as intravascular brachytherapy, the technique has been used with several radiation sources, and researchers have obtained success in decreasing the rate of restenosis in some patient populations. In order to study the radiation dosimetry in the patient and radiological protection for the attending staff for this therapy, radiation dose distributions for monoenergetic electrons and photons (at nine discrete energies) were calculated for blood vessels of diameter 0.15, o,30 and 0.45 cm with balloon and wire sources using the radiation transport code MCNP4B. Specific calculations were carried out for several candidate radionuclides as well. Two s tent sources (metallic prosthesis that put inside of patient's artery through angioplasty) employing 32 P are also simulated. Advantages and disadvantages of the various radionuclides and source geometries are discussed. The dosimetry developed here will aid in the realization of the benefits obtained in patients for this promising new technology. (author)

  17. Intravascular blood coagulation after irradiation

    International Nuclear Information System (INIS)

    The problems of activation of intravascular blood coagulation (JVBC) at different stages after irradiation, are considered. JVBC peculiarities (disseminated intravascular syndrome (DIV) or thrombo hemorrhagic syndrome) are investigated. Literature on alterations which take place in the organism under effect of ionizing irradiation is analyzed. This analysis proves the characteristic features of thrombinogenesis activation and development of DIV syndrome not only in the early post-radiation period, but in the middle of radiation disease, as well. It is also shown that ionizing radiation activizes the hemocoagulation process and causes IVBC in the case of both local and general irradiation

  18. Linfoma não-Hodgkin de órbita: relato de caso Non-Hodgkin orbital lymphoma: case report

    Directory of Open Access Journals (Sweden)

    Cristiane do Prado Silva

    2008-04-01

    Full Text Available O objetivo é relatar manifestação incomum de linfoma não-Hodgkin de órbita. Paciente masculino, de 75 anos, se apresentou com queixa de lacrimejamento crônico bilateral. Havia feito dacriocistorrinostomia endonasal à direita e à esquerda por duas vezes, sem sucesso. Ao exame, massas de consistência fibroelástica, em topografia das "bolsas" de gordura das pálpebras inferiores e proptose axial. O paciente negava outros sintomas ou sinais sistêmicos. Hemograma sem alteração, hormônios tireoidianos normais. A tomografia computadorizada mostrava infiltrado difuso na órbita e proptose axial. Biópsia de gordura orbitária e de medula óssea diagnosticaram linfoma não-Hodgkin. O paciente foi tratado com quimioterapia, sendo em seguida submetido à cirurgia da via lacrimal bilateral, com resolução do quadro. A doença sistêmica que exigia diagnóstico e tratamento adequados para que se tivesse bom prognóstico estava mascarada pelo quadro de epífora bilateral.The purpose is to report an unusual case of orbital non-Hodgkin lymphoma. A 75-year-old man presented with bilateral chronic epiphora complaint and inferior eyelid tumors, axial proptosis, without previous systemic manifestation. The patient was submitted to bilateral endonasal dacryocystorhinostomy twice and the epiphora complaint persisted. The inferior eyelid and bone marrow biopsy revealed non-Hodgkin lymphoma. The patient was treated with systemic chemotherapy and dacryocystorhinostomy with good resolution. The precise diagnosis and the treatment were very important to reach a good resolution of the bilateral epiphora complaint.

  19. 21 CFR 880.5200 - Intravascular catheter.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Intravascular catheter. 880.5200 Section 880.5200 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... Devices § 880.5200 Intravascular catheter. (a) Identification. An intravascular catheter is a device...

  20. Linfomas del tubo digestivo y glándulas anexas en pacientes con SIDA. Serie de casos

    Directory of Open Access Journals (Sweden)

    Marcelo Corti

    2006-01-01

    linfoma. La incidencia global de linfomas (primarios del sistema nervioso central, no Hodgkin sistémicos y de Hodgkin durante el período de estudio fue de 2,9% (54 casos; 17 pacientes (32% tuvieron diagnóstico de LNH sistémicos; 10 (58,8% de ellos tuvieron presentación extranodal al momento del inicio de las manifestaciones clínicas y 8 (80% comprometieron el tubo digestivo y las glándulas anexas (parótida, cavum, esófago, estómago, duodeno, colon derecho en 2 casos e hígado en el restante, como LNH primarios, de alto grado y de fenotipo "B". Todos los pacientes presentaron síntomas "B" al momento del diagnóstico. De acuerdo con los criterios de estadificación de Lugano, 4 se encontraban en el estadio I, 2 pertenecían al IIa y uno al III y al IV, respectivamente. El linfoma de duodeno fue el único de tipo Burkitt en esta serie y se detectó el genoma del virus de Epstein-Barr en las muestras de biopsias del tumor, así como también en el que comprometió el hígado. Cuatro pacientes recibieron tratamiento con quimioterapia sistémica más factor estimulante de colonias de granulocitos y TARGA; 2 de ellos (cavum y uno de los de colon tienen una sobrevida prolongada con reconstitución inmune luego de 5 y 6 años del diagnóstico, respectivamente. La mediana de supervivencia de los pacientes tratados con TARGA más quimioterapia fue de 33 meses. La mediana de supervivencia de los otros pacientes fue de 90 días. Conclusión: los LNH del tracto gastrointestinal son una grave complicación de la enfermedad VIH/SIDA avanzada. El diagnóstico precoz seguido del tratamiento combinado de quimioterapia más TARGA mejora el pronóstico y la supervivencia de estos pacientes.

  1. Linfoma no Hodgkin extraganglionar. Reporte de un caso

    Directory of Open Access Journals (Sweden)

    José Ignacio Larquin Comet

    2008-01-01

    Full Text Available El linfoma no Hodgkin extraganglionar es un trastorno linfoproliferativo crónico de causa aún dudosa. Se reporta un caso de una paciente con una masa tumoral a nivel del anillo de Waldeyer, se realizó el diagnóstico por biopsia de la lesión de un linfoma no Hodgkin de alto grado de malignidad extraganglionar. Se inició tratamiento con esquema ChopBleo y se obtuvo repuesta favorable, presentó recaída hematológica dos años más tarde, por lo que se inició tratamiento con radioterapia de cabeza y cuello con resultados alentadores. Actualmente se mantiene asintomática.

  2. Linfoma de Burkitt en un portador de granulomatosis de Wegener

    Directory of Open Access Journals (Sweden)

    Kryssia Rodríguez-Castro

    2005-10-01

    Full Text Available Se reporta el caso de un paciente costarricense portador de granulomatosis de Wegener, en tratamiento con ciclofosfamida y prednisona, quien desarrolla un linfoma de Burkitt que lo lleva a la muerte. Se menciona la posible relación entre estas dos patologías.This is a report of a costarrican male with Wegener' s granulomatosis undergoing treatment with prednisone and cyclophosphamide, he developed a fatal Burkitt' s lymphoma. The possible relationship between these two disorders is addressed.

  3. Linfoma de celulas B de la zona marginal extraganglionar del tejido linfoide asociado a mucosa (linfoma MALT) de pulmón

    OpenAIRE

    Carlos Vergara-Uzcategui; Melizabeth Ruiz

    2014-01-01

    Los Linfomas Pulmonares Primarios son extremadamente raros (0,4% de los linfomas extraganglionares), y generalmente son de tejido linfoide asociado a mucosas (tipo MALT), con ocasionales linfomas de células grandes difusos. Los síntomas son inespecíficos, y casi la mitad de los pacientes son asintomáticos. Se presenta el caso de un paciente masculino de 56 años de edad, quien presentó durante 7 meses accesos diarios de tos seca, de predominio nocturno, asociados en el último mes a fiebre de 3...

  4. Intravascular Stenting in Microvascular Anastomoses

    DEFF Research Database (Denmark)

    Assersen, Kristine; Sørensen, Jens

    2015-01-01

    Background The effect of intravascular stenting (IVaS) on microvascular anastomoses has given adverse results. For experienced microsurgeons the benefit of IVaS is doubtful. We have investigated the potential benefit of the IVaS technique for two groups of inexperienced microsurgeons with differe...

  5. Quinine induced disseminated intravascular coagulopathy

    OpenAIRE

    Nikolaus Hammerl; Muhammad Kashif Nadeem

    2011-01-01

    There are only a handful of case reports of Disseminated Intravascular Coagulopathy (DIC) as a result of quinine use however it is important to recognise this early especially when quinine has not been prescribed for managing malaria. Off licence use of any medicine may result in serious complications, quinine induced DIC is one of them.

  6. Intravascular bronchio-alveolar tumor

    International Nuclear Information System (INIS)

    In 1975 Dail and Liebow described the clinical and pathological characteristics of a pulmonary tumor which they dominated intravascular bronchio-alveolar tumor (IVBAT). Our aim is to acquaint radiologists with the existence of this tumor by describing the radiologic findings in 2 patients with IVBAT, 1 with hepatic involvement ant the other with pulmonary osteoarthropathy. (author). 7 refs.; 2 figs

  7. ENFERMEDAD RENAL POLIQUISTICA ASOCIADA A LINFOMA EXTRANODAL EN UN CANINO

    Directory of Open Access Journals (Sweden)

    Diego Echeverry B

    2006-12-01

    Full Text Available Objetivo: Presentar el caso de un paciente canino, con enfermedad renal poliquística, asociada alinfoma extranodal. Materiales y métodos: Se estudió el caso de un paciente canino de raza SiberianHusky de 7 años de edad, al que se le encontraron múltiples nódulos renales bilaterales, condiagnóstico histopatológico de linfoma extranodal. Resultados: Se expone el caso clínico de unpaciente canino de raza Siberian Husky, que es presentado a consulta dermatológica por exhibirlesiones alopécicas multifocales. Una vez realizado el examen físico sistemático se evidenció demanera incidental nefromegalia. Los exámenes paraclínicos e histopatológicos aplicadosdemostraron la presencia de enfermedad renal poliquística asociada a linfoma extranodal, comoconsecuencia se presento falla renal crónica. Conclusiones: El linfoma extranodal renal es unaentidad patológica de rara presentación, clínicamente cursa con signos muy similares a otrasalteraciones tumorales, su diagnóstico suele ser histopatológico.

  8. Linfoma no Hodgkin de células del manto con infiltración renal y glomerulopatía mesangiocapilar asociada

    Directory of Open Access Journals (Sweden)

    Raymed Antonio Bacallao Méndez

    2013-06-01

    Full Text Available El linfoma de células del manto es una forma infrecuente de linfoma no Hodgkin con alta frecuencia de recaídas y peor pronóstico. Los linfomas pueden inducir daño renal de diferentes modos, entre los que se encuentran la infiltración renal y el desarrollo de glomerulopatías. Se presentó un caso en el que se asocia el comienzo clínico de un linfoma de células del manto con infiltración parenquimatosa renal y glomerulonefritis mesangiocapilar sin crioglobulinemia. Este constituye el primer caso reportado con esta asociación y pone en evidencia las diferentes formas de afectación renal del linfoma no Hodgkin y el valor del estudio histológico renal, para el diagnóstico y el pronóstico de las enfermedades oncohematológicas con daño renal.

  9. Linfoma não-Hodgkin em crianças com imunodeficiência: relato de cinco casos Non-Hodgkin's lymphoma in children with immunodeficiency: report of five cases

    OpenAIRE

    Maria Christina L. A. Oliveira; Rodrigues, Adriana R.; Keyla C. Sampaio; Ana Cecília S. C. Gomes; Marcos B. Viana

    2008-01-01

    Neste estudo é relatado o quadro clínico de cinco crianças com linfoma não-Hodgkin secundário a imunodeficiência ou imunossupressão: três portadoras do vírus da imunodeficiência humana, uma com imunodeficiência primária e uma após transplante hepático. De acordo com a classificação atual, os tipos histológicos foram: linfoma linfoblástico de células B precursoras (2), linfoma cutâneo de grandes células anaplásico (1), linfoma de células B periféricas, sugestivo de Burkitt (1), e linfoma linfo...

  10. UM TRATADO PARA O AMOR

    OpenAIRE

    Maria José Caldeira do Amaral

    2015-01-01

    No Tratado do Amor Cortês - Tractatus de Amore - André Capelão deseja oferecer ao leitor a arte cortês de amar, a beleza do desejo erótico e a disciplina da paixão constitutiva dessa arte que é amar. O maior argumento dessa obra é efetivar o suspiro fundo que a dimensão amorosa infunde na alma do homem e da mulher aos quais foi concedida a virtude. Para esse autor, escriba da chancelaria real e talvez, não se sabe com certeza, um Ordo Sacratus, o amor é a raiz de toda cortesia, a fonte de tod...

  11. Leucemia / linfoma T del adulto: Primer caso en Cuba

    Directory of Open Access Journals (Sweden)

    Jorge E. Muñío Perurena

    2003-06-01

    Full Text Available Se presentó el caso de una paciente con diagnóstico de linfoma no Hodgkin de histología agresiva, en el año 1990, que por los hallazgos clínicos y resultados de los exámenes complementarios realizados se sospechó la posibilidad de una leucemia / linfoma tipo T del adulto (LLTA relacionada con la infección por el virus linfotrópico de células T humanas tipo I (conocido como HTLV-I, lo cual fue confirmado por los resultados de los estudios virológicos. Se observó comportamiento evolutivo y respuesta terapéutica tórpidos. Falleció en los primeros 4 meses de efectuado el diagnóstico, lo que corroboró lo publicado en la literatura médica sobre este tema. Este es el primer caso diagnosticado en Cuba de una leucemia / linfoma tipo T del adulto (LLTA relacionada con la infección por el virus linfotrópico de células T humanas tipo I (HTLV-IThe case of a female patient with diagnosis of non Hodgkin lymphoma of aggressive histology in 1990 was presented .According to the clinical findings and to the results of the complementary tests made, it was suspected the possibility of adult T-cell leukemia/lymphoma (ATLL related to human T lymphotropic virus type I (HTLV-1 infection, which was confirmed by the results of the virological studies. It was observed a torpid evolutive behavior and therapeutic response. The patient died during the first 4 months of the diagnosis, which corroborated what is published in medical literature on this topic.This is the first case diagnosed in Cuba of an adult T-cell leukemia/lymphoma associated with HTLV-1.

  12. Linfomas cutáneos: Aspectos relevantes Cutaneous lynphomas: Significant aspects

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    Bertha Beatriz Socarrás Ferrer

    2005-04-01

    Full Text Available Los linfomas cutáneos constituyen un amplio grupo dentro de los linfomas no hodgkinianos. Incluyen varios tipos de desórdenes linfoproliferativos y se clasifican según su origen en T ó B, cuadro clínico y morfología. Dentro de estos se encuentran la micosis fungoides y el síndrome de Sézary, que son entidades que aunque difieren en sus manifestaciones clínicas, se cree que son variantes de un mismo trastorno linfoproliferativo del linfocito T CD4. Estos linfomas no hodgkinianos de células T aparecen entre los 40 y 60 años y es 2,2 veces más frecuente en el sexo masculino que en el femenino. Un adecuado tratamiento depende de un exacto diagnóstico morfológico, inmunológico, genético y molecular que permitiría una más rápida remisión, una mayor sobrevida y la incorporación de estos individuos a la vida útil de la sociedad.The cutaneous lymphomas constitute a large group within the non-Hodgkin lymphomas. They include various types of lymphoproliferative disorders and they are classified according to their origin, clinical picture and morphology in T or B. The fungoid mycosis and Sézary's syndrome are among them. Although these entities differ in their clinical manifestations, it is believed that they are variants of a same lymphoproliferative disorder of the CD4 T-lymphocyte. These non-Hodgkin lymphomas of T-cells appear in individuals aged 40-60 and they are two times more frequent in males than in females. An adequate treatment depends on an accurate morphological, immunological, genetic and molecular diagnosis that will allow a faster remission, a higher survival and the incorporation of these individuals to society's useful life.

  13. Actualidad clínica-biológica de los linfomas T cutáneos

    OpenAIRE

    María E. Faxas García

    2003-01-01

    Los linfomas cutáneos resultan modelos útiles para el estudio de los mecanismos patogénicos de las enfermedades linfoproliferativas dado que para el diagnóstico y el seguimiento, las muestras de tejido se obtienen a través de métodos no invasivos. Aunque los linfomas T cutáneos se desarrollan a partir de los linfocitos T residentes en la piel, otras células y diversos factores asociados al tejido linfoide participan en la linfomagénesis. La aparición de estos linfomas en la piel no excluye la...

  14. É possível diferenciar derrames pleurais linfocíticos secundários a tuberculose ou linfoma através de variáveis clínicas e laboratoriais? Differentiating between tuberculosis-related and lymphoma-related lymphocytic pleural effusions by measuring clinical and laboratory variables: Is it possible?

    Directory of Open Access Journals (Sweden)

    Leila Antonangelo

    2012-04-01

    Full Text Available OBJETIVO: Descrever características clínicas e laboratoriais em pacientes com derrames pleurais linfocíticos secundários a tuberculose ou linfoma, a fim de identificar as variáveis que possam contribuir no diagnóstico diferencial dessas doenças. MÉTODOS: Estudo retrospectivo com 159 pacientes adultos HIV negativos com derrame pleural linfocítico secundário a tuberculose ou linfoma (130 e 29 pacientes, respectivamente tratados no Ambulatório da Pleura, Instituto do Coração, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo (SP, entre outubro de 2008 e março de 2010. RESULTADOS: A média de idade e de duração dos sintomas foi menor no grupo tuberculose que no grupo linfoma. Os níveis pleurais de proteínas, albumina, colesterol, amilase e adenosina desaminase (ADA, assim como os níveis séricos de proteínas, albumina e amilase, foram maiores no grupo tuberculose, enquanto os níveis séricos de colesterol e triglicérides foram maiores no grupo linfoma. As contagens de leucócitos e linfócitos no líquido pleural foram maiores no grupo tuberculose. Células malignas estavam ausentes no grupo tuberculose, entretanto, linfócitos atípicos foram observados em 4 desses pacientes. No grupo linfoma, a citologia para células neoplásicas foi positiva, suspeita e negativa em 51,8%, 24,1% e 24,1% dos pacientes, respectivamente. A imunofenotipagem do líquido pleural foi conclusiva na maioria dos pacientes com linfoma. CONCLUSÕES: Nossos resultados demonstram semelhanças clínicas e laboratoriais entre os pacientes com tuberculose ou linfoma. Embora os níveis de proteínas e ADA no líquido pleural tendam a ser mais elevados no grupo tuberculose que no grupo linfoma, mesmo essas variáveis mostraram uma sobreposição. Entretanto, nenhum paciente com tuberculose apresentou níveis de ADA no líquido pleural inferiores ao ponto de corte (40 U/L.OBJECTIVE: To describe clinical and laboratory characteristics in patients with tuberculosis-related or lymphoma-related lymphocytic pleural effusions, in order to identify the variables that might contribute to differentiating between these diseases. METHODS: This was a retrospective study involving 159 adult HIV-negative patients with tuberculosis-related or lymphoma-related lymphocytic effusions (130 and 29 patients, respectively, treated between October of 2008 and March of 2010 at the Pleural Diseases Outpatient Clinic of the University of São Paulo School of Medicine Hospital das Clínicas Heart Institute, in the city of São Paulo, Brazil. RESULTS: Mean age and the mean duration of symptoms were lower in the tuberculosis group than in the lymphoma group. The levels of proteins, albumin, cholesterol, amylase, and adenosine deaminase (ADA in pleural fluid, as well as the serum levels of proteins, albumin, and amylase, were higher in the tuberculosis group, whereas serum cholesterol and triglycerides were higher in the lymphoma group. Pleural fluid leukocyte and lymphocyte counts were higher in the tuberculosis group. Of the tuberculosis group patients, none showed malignant cells; however, 4 showed atypical lymphocytes. Among the lymphoma group patients, cytology for neoplastic cells was positive, suspicious, and negative in 51.8%, 24.1%, and 24.1%, respectively. Immunophenotyping of pleural fluid was conclusive in most of the lymphoma patients. CONCLUSIONS: Our results demonstrate clinical and laboratory similarities among the patients with tuberculosis or lymphoma. Although protein and ADA levels in pleural fluid tended to be higher in the tuberculosis group than in the lymphoma group, even these variables showed an overlap. However, none of the tuberculosis group patients had pleural fluid ADA levels below the 40-U/L cut-off point.

  15. The issue of refractory disease in follicular and other lymphoma subtypes A refratariedade no linfoma folicular e em outros linfomas

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    Marco Ruella

    2009-08-01

    Full Text Available The outcome of lymphoma has definitely improved over the last few decades which is mainly due to the introduction and development of novel and effective therapeutic approaches. Nevertheless, a small though notable group of patients may display a poor response to treatments, with a true refractoriness or a transient response followed by early relapse. The present review addresses the issue of refractory disease among patients with lymphoma, focusing on the overall incidence and the main clinical aspects associated with refractoriness.A evolução dos linfomas tem sido definitivamente melhorada ao longo das últimas décadas. Isto se deve principalmente devido à introdução e desenvolvimento de novas e efetivas abordagens terapêuticas. Apesar disto, uma pequena parcela deste notável grupo de pacientes pode apresentar uma pobre resposta aos tratamentos, com uma verdadeira refratariedade, ou com resposta transitória e precocemente uma recidiva. A presente revisão aborda este assunto da doença refratária nos pacientes com linfoma, enfocando sua incidência global e os principais aspectos clínicos associados à refratariedade.

  16. Análise de achados de imagem e alterações clínicas em pacientes com linfoma

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    Caldas Flávio Augusto Ataliba

    2002-01-01

    Full Text Available A tomografia computadorizada é atualmente o estudo de imagem de escolha para a detecção e estadiamento de linfomas. A tomografia computadorizada é capaz de mensurar com acurácia significativa a extensão e o volume do tumor e prover informações que possam ser usadas para planejar uma estratégia terapêutica apropriada. O presente trabalho teve como objetivo descrever e analisar os achados de imagem obtidos por meio de tomografia computadorizada de tórax e abdome, acompanhada de ultra-sonografia de abdome total de pacientes com diagnóstico de linfoma e com sorologia negativa para o vírus HIV, alterações clínicas, como a queixa que levou o paciente a procurar o serviço de saúde, já revelando sinais de acometimento da doença linfocitária, neste momento ainda não diagnosticada, e alterações ao exame físico nesta primeira consulta. A amostra estudada foi composta por 30 pacientes, sendo que, destes, 40% teriam o diagnóstico de linfoma não-Hodgkin, 46,6% de linfoma Hodgkin, 10% de linfoma de Burkitt e 3,3% com o diagnóstico de linfoma linfoblástico.

  17. Linfoma primario del sistema nervioso central en pacientes inmunocompetentes / Primary central nervous system lymphoma in immunocompetent patients

    Scientific Electronic Library Online (English)

    Gerardo, Guinto-Balanzar; Ignacio, Félix-Espinoza; Salvador, De Anda Ponce-de -León; Norma C, Aréchiga-Ramos; Víctor, Arteaga-Larios; Kalman, Kovacs.

    2005-12-01

    Full Text Available El linfoma primario del sistema nervioso central ha sido informado con frecuencia en pacientes que padecen síndromes de inmuno deficiencia. Sin embargo ésta no es una condición necesaria para su presentación, dado que existen informes de la enfermedad en sujetos inmunológicamente competentes. En el [...] presente trabajo se analizaron en forma retrospectiva, los expedientes de 22 pacientes inmunocompetentes con diagnóstico confirmado de linfoma primario encefálico, se revisó la literatura mundial, con el fin de analizar objetivamente las manifestaciones clínicas, comportamiento radiológico, aspecto histopatológico, dificul tades diagnósticas y terapéuticas, así como las consideraciones pro nósticas. El promedio de edad fue de 65 años y con una relación equitativa hombre/mujer. El tiempo de evolución del cuadro clínico fue de 80.4 días y estuvo dominado por cefalea y déficit neurológico focal. En cuatro pacientes se encontraron lesiones múltiples, mientras que en el resto se trataba de lesiones únicas con localización predominante en la región periventricular de los hemisferios cerebrales. Todos los pacientes fueron manejados inicialmente con esteroides y sometidos a toma de biopsia por estereotaxia. La variedad histológica más frecuente fue la de células grandes difusas y la totalidad de los casos reaccionaron positivamente a antígenos de células B en la inmunohistoquímica. Los 22 pacientes fueron tratados con radio terapia y 10 de ellos además con quimioterapia con metotrexato. La supervivencia promedio fue de 11 meses en los pacientes radiados y de 36 meses en los que se agregó quimioterapia. Abstract in english Primary central nervous system lymphoma has been traditionally described in patients with immunodeficiency syndromes; however, there is an increasing number of immunocompetent patients with this type of tumor that have been reported recently. In this paper we have retrospectively analyzed 22 immunoc [...] ompetent patients with a confirmed diagnosis of primary lymphoma of the brain. The mean age in this group was 65 years with a similar male/female ratio. The time of evolution of the clinical course was 80.4 days and it was mainly characterized by headache and focal neurological deficit. In four patients multiple lesions were observed, while the remaining presented single lesions mainly located in the periventricular area of the cerebral hemispheres. All patients were initially administered steroids and a stereotactic biopsy was performed. The majority of tumors were histologically classified as diffuse large cells and all of them showed a positive reaction to B cells antigens on immunohistochemistry. All patients were treated with radiotherapy and in 10 of them, chemotherapy with methotrexate was also indicated. The mean survival rate was 11 months among patients treated with radiotherapy alone and increased to 36 months when chemotherapy was added.

  18. Características clínicas y resultados terapéuticos de linfomas no Hodgkin de células grandes B mediastinal primarios

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    Reysel Chávez Medina

    2011-06-01

    Full Text Available Se realizó un estudio observacional, descriptivo y retrospectivo para evaluar las características clinicobiológicas y los resultados terapéuticos del linfoma de células grandes B mediastinal primario, en 34 pacientes atendidos en el Hospital Clinicoquirúrgico "Hermanos Ameijeiras" desde junio de 1989 a febrero de 2009. Se halló predominio del sexo femenino (61,8 %, edad promedio de 31,5 años (19 a 61 años y de la raza blanca (70,6 %. Fueron más frecuentes los estadios localizados (67,7 %, sin síntomas B (64,7 % y con gran masa tumoral (70,6 %. La supervivencia global y la supervivencia libre de progresión a los 5 años fueron 53,4 y 43,4 %, respectivamente. La supervivencia global a los 3 años de los pacientes tratados con MACOPB/VACOPB, CHOP y R-CHOP fue de 77,7; 30,4 y 100 %, respectivamente. Se comprobó que los pacientes tratados con MACOPB/VACOPB tuvieron mejores resultados que los tratados con CHOP. El índice pronóstico internacional ajustado a la edad no fue predictor de supervivencia. En el análisis multivariable, el único predictor de supervivencia fue el tratamiento utilizado (CHOP contra MACOPB. El uso rutinario de la radioterapia no tuvo impacto significativo en la supervivencia global ni en la supervivencia libre de progresión a los 5 años.

  19. Iatrogenic intravascular pneumocephalus secondary to intravenous catheterization

    International Nuclear Information System (INIS)

    The presence of pneumocephalus without a history of intracranial or intrathecal procedures is a significant radiographic finding. Although pneumocephalus means a violation of the dural barrier or the presence of infection, intravascular pneumocephalus is different from intraparenchymal pneumocephalus and its benign nature must be known in the presence of intravenous catheterization. Herein, we present a case of iatrogenic intravascular pneumocephalus with CT findings. To our knowledge, there are only a few reported cases of iatrogenic intravascular pneumocephalus in the literature. Careful intravenous catheterization and diagnosis of the condition on imaging helps to prevent unnecessary treatment procedures. (orig.)

  20. Iatrogenic intravascular pneumocephalus secondary to intravenous catheterization

    Energy Technology Data Exchange (ETDEWEB)

    Yildiz, Altan; Oezer, Caner; Egilmez, Hulusi; Duce, Meltem Nass; Apaydin, Demir F.; Yalcinoglu, Orhan [Department of Radiology, Faculty of Medicine, Mersin University (Turkey)

    2002-03-01

    The presence of pneumocephalus without a history of intracranial or intrathecal procedures is a significant radiographic finding. Although pneumocephalus means a violation of the dural barrier or the presence of infection, intravascular pneumocephalus is different from intraparenchymal pneumocephalus and its benign nature must be known in the presence of intravenous catheterization. Herein, we present a case of iatrogenic intravascular pneumocephalus with CT findings. To our knowledge, there are only a few reported cases of iatrogenic intravascular pneumocephalus in the literature. Careful intravenous catheterization and diagnosis of the condition on imaging helps to prevent unnecessary treatment procedures. (orig.)

  1. Complicaciones neurológicas en pacientes con linfomas

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    Nelson Gómez Viera

    2000-06-01

    Full Text Available Se realizó un estudio descriptivo prospectivo en 270 pacientes con diagnóstico de linfoma ingresados en el Servicio de Hematología del Hospital Clinicoquirúrgico "Hermanos Ameijeiras" de Ciudad de La Habana, Cuba, en el período comprendido del 1ro de marzo de 1996 al 31 de diciembre de 1998, para conocer las complicaciones neurológicas. Se detectaron 26 pacientes con complicaciones neurológicas. De 188 enfermos con linfomas no-Hodgkin, el 12,2 % presentó manifestaciones neurológicas. En estos pacientes, la infiltración leptomeníngea fue la complicación neurológica más frecuente. En los 82 pacientes con enfermedad de Hodgkin, solamente 3,6 % tuvieron alteraciones neurológicas y la infección por Herpes zoster fue la más común. Se observó el mayor porcentaje de pacientes con síntomas y signos atribuibles a compresión de la médula espinal y a la alteración de pares craneales, la cefalea como el síntoma más común y el déficit motor, el signo más frecuente. Se comprobó que los pacientes con linfoma no Hodgkin de alto grado de malignidad presentaron el mayor porcentaje de complicaciones neurológicas (28,7 % y el tiempo promedio entre el diagnóstico del linfoma y el diagnóstico de la complicación neurológica fue menor en estos enfermos (5,5 meses. El tiempo de supervivencia después del diagnóstico de las manifestaciones neurológicas en la mayoría de los pacientes fue inferior a un año. De los 14 pacientes fallecidos, la complicación neurológica fue la principal causa directa de la muerteA prospective and descriptive study was carried out in 270 patients diagnosed of lymphoma, admitted in Hematology Service of "Hermanos Ameijeiras" Clinical Surgical Hospital in Havana City, Cuba, from March 1, 1996 to December 31, 1998, to assess neurologic complications. 26 patients presenting with neurologic complications were detected. From 188 sick persons with non-Hodgkin's lymphoma, 12,2 % had neurologic manifestations. In these patients, leptomeninges infiltration was the more frequent neurologic complication. In 82 patients with Hodgkin's disease, only 3,6 % had neurologic alteration and Herpes zoster infection was the commonest one. We found higher percent of patients with syndromes attributable to spinal cord compression and to craneal pars disturbance, headache was commonest and motor deficit the more frequent one. It was confirmed that patients carriers of high grade malinancy non-Hodgkin' s lymphoma, had the great percentage of neurologic complications (28,7 %, and average time between diagnosis of lymphoma and that of neurologic complications was shorter in these patients was (5,5 months. Survival after diagnosis of neurologic manifestations in most patients was under l year. In 14 patients deceaced, neurologic complication was main direct cause of death

  2. Dosimetric model for intravascular brachytherapy

    International Nuclear Information System (INIS)

    Full text: Intravascular brachytherapy has been shown to be a prophylaxis for restenosis. Adventitial macrophages, which are extremely radiosensitive, initiate neointima formation. A model of the dose levels of the treatment range is developed, assuming that the adventitia is the target tissue. If the adventitia receives a dose of less than 10 Gy, it is assumed the treatment will be ineffective. If the dose to any part of the wall is above 30 Gy, it is assumed that the treatment could be detrimental. Hence the treatment range is between 10 and 30 Gy, with 20 Gy being the optimum dosage to the adventitia. An algorithm using numerical integration of published dose kernels calculates the dose at any point surrounding a beta (32P) line source of finite length. Dose profiles were obtained to demonstrate edge effects. For long lesions, the source is often stepped along the artery. Dose changes due to separation or overlapping of sources during source stepping procedures were also determined. Isodose curves were superimposed on intravascular ultrasound images to demonstrate dose levels. For an exposure time of 60 seconds with a 200mCi source, the optimum dose of 20 Gy occurs at a distance 1.94mm from the centre of the source. The upper limit of the treatment dose range (30 Gy) occurs at 1.59mm. The lower limit of the treatment dose range (10 Gy) occurs at 2.7mm. Significant perturbations to the treatment dose range can be caused by non-centering of the source, edge effects and separation or overlapping of sources in stepping procedures. Despite these concerns, many successful procedures have been reported and this implies that the model is over simplified and requires modifications. Copyright (2000) Australasian College of Physical Scientists and Engineers in Medicine

  3. Linfomas asociados a infección por VIH en pacientes del Hospital Clínico San Borja Arriarán / Fundación Arriarán2001-2008 Lymphomas associated with HIV infection in patients at the Hospital San Borja Arriarán /Fundación Arriarán 2001-2008, Santiago, Chile

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    Álvaro Pizarro

    2013-02-01

    Full Text Available Introducción: Los linfomas de Hodgkin (LH y no Hodgkin (LNH se asocian con alta frecuencia al síndrome de inmunodeficiencia humana en adultos. Objetivo: Sistematizar los aspectos clínicos e histológicos de los linfoma que afectan a pacientes con SIDA, su tratamiento y resultados globales en nuestra institución. Pacientes y Métodos: Análisis retrospectivo de pacientes con linfoma asociado a VIH entre enero de 2001 y diciembre de 2008 en el complejo hospitalario San Borja Arriarán. Resultados: Se obtuvo información de 30 pacientes con LNH y 7 LH, con una mediana de 40 años. Los tipos histológicos predominantes fueron linfoma de Burkitt (47 %, linfoma difuso de células grandes de estirpe B (37 % y LNH de estirpe T (10%. No se diagnosticaron LNH del SNC ni linfoma de cavidades. Casi la totalidad de los pacientes (86,7% con LNH se trataron con esquema CHOP, 57% de quienes recibieron tratamiento presentaron progresión o recaída desde remisión completa, ofreciéndoles una quimioterapia de rescate a cuatro pacientes. El 73% de los pacientes que recibieron CHOP lograron completar entre cinco y seis ciclos de quimioterapia. El uso de quimioterapia CHOP para el subgrupo de pacientes con linfoma de Burkitt alcanzó bajos porcentajes de remisión completa y mayoritariamente progresó la enfermedad, siendo esta quimioterapia, inefectiva para mejorar la sobrevida, especialmente en los pacientes de riesgo alto. Se encontraron diferencias estadísticamente significativas en sobrevida según el IPIae (índice internacional pronóstico ajustado por edad al ingreso. Conclusión: El LNH en los pacientes con VIH tratados con los protocolos de quimioterapia PANDA persiste en nuestro medio como una enfermedad de muy mal pronóstico comparado con los resultados en la literatura internacional. La incorporación de nuevos fármacos de demostrada utilidad como rituximab y esquemas específicos de quimioterapia podrían mejorar estos resultados. El establecimiento de grupos pronósticos establecidos por IPIae puede orientar el trabajo clínico para el uso de quimioterapia ajustada a su riesgo específico y optimizado según tipo histológico.Introduction: Hodgkin lymphomas (HL and non Hodgkin lymphomas (NHL are frequently associated to acquired immunodeficiency syndrome in adults. Objective: To systematize the clinical features and histological characteristics of lymphomas in AIDS patients, its treatment and outcomes in our institution. Patients and Methods: Retrospective analysis of patients with HIV-associated lymphoma between January 2001 and December 2008 at the San Borja Arriarán Hospital complex. Results: Information was obtained from 30 patients with NHL and 7 with HL, with a median of 40 years. The majority of tumors were Burkitt lymphoma (47%, diffuse large cell lymphoma B-cell (37% and NHL of T lineage (10%. There was no CNS or cavities lymphoma. Almost all patients (86.7% with NHL were treated with CHOP chemotherapy, 57% of those receiving treatment had progression or relapse from complete remission. A rescue chemotherapy was indicated in 4 patients. 73% of patients receiving CHOP, complete 5 to 6 cycles of chemotherapy. The use of CHOP chemotherapy for the subgroup of patients with Burkitt lymphoma achieved low rates of complete remission and frequent relapse and disease progression, showing that CHOP was ineffective in improving survival, especially in high risk patients. We found statistically significant differences in survival according to IPIae (International prognostic Index age-adjusted. Conclusion: Non-Hodgkin lymphoma in HIV patients treated with chemotherapy protocols PAlNDA persists in our environment as a disease with a poor prognosis compared with findings in the international literature. The incorporation of new drugs of proven utility as rituximab and specific schemes chemotherapy could improve these results. The establishment of prognostic groups established by IPIae can guide clinical work for the use of chemotherapy tailored to their specific risk and optimized according to histologic

  4. Diagnóstico y tratamiento de pacientes con linfomas primarios del sistema nervioso central (LPSN y sindrome de inmunodeficiencia adquirida (SIDA

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    Luis E Raez

    1999-07-01

    Full Text Available La incidencia del linfoma primario del sistema nervioso central (LPSNC ha crecido rápidamente. El LPSNC as una complicación letal en pacientes con SIDA. Objetivo: Nuestro objetivo fue estudiar la historia natural, métodos diagnósticos, al tratamiento y los factores pronósticos para la sobrevida de 75 pacientes con LPSNC y SIDA seguidos en el Jackson Memorial Hospital/Universidad de Miami. Resultados: La edad media fue de 37 años. El 84% de los pacientes eran hombres y el 55% hispanos. Factores de riesgo más comunes para SIDA fueron homosexualidad y múltiples compañeros sexuales. La cuenta promedio de CD4 fue de 15/ul y al promedio de LDH fue 1.5 veces al normal. La tomografía computarizada del cerebro mostraba lesiones múltiples en el 44% de los pacientes. Gammagrafia computarizada de emisión de fotones con talio-201 (SPECT del cerebro se realizó en 2/3 de los pacientes. Las histologías más comunes en las biopsias fueron: linfoma inmunoblástico y linfoma de células grandes. La radiación craneana fue ineficiente en el 50% de los pacientes tratados. La sobrevida promedio del grupo fue de 2.2 meses. Análisis univariado y multivariado mostraron que la mayor sobrevida se asociaba con una buena capacidad funcional (ECOG=1-2 vs 3-4. La presencia previa de infecciones oportunistas, la presencia de factores de riesgo de SIDA, las cuentas de CD4, niveles de LDH y raza no mostraron influencia en la sobrevida. Conclusiones: LPSNC es una neoplasia con pronóstico muy pobre y corta sobrevida aun con radioterapia del SNC. La capacidad funcional parece ser al factor de sobrevida más importante. No se encontraron diferencias en la presentación clínica ni el resultado entre pacientes hispanos y no hispanos. ( Rev Med Hered 1999; 10:96-104 .

  5. UM TRATADO PARA O AMOR

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    Maria José Caldeira do Amaral

    2015-07-01

    Full Text Available No Tratado do Amor Cortês - Tractatus de Amore - André Capelão deseja oferecer ao leitor a arte cortês de amar, a beleza do desejo erótico e a disciplina da paixão constitutiva dessa arte que é amar. O maior argumento dessa obra é efetivar o suspiro fundo que a dimensão amorosa infunde na alma do homem e da mulher aos quais foi concedida a virtude. Para esse autor, escriba da chancelaria real e talvez, não se sabe com certeza, um Ordo Sacratus, o amor é a raiz de toda cortesia, a fonte de todo bem. Nosso objetivo, então, é encontrar nessa suma amorosa construída nos enlaces da Literatura de Cavalaria Medieval, os desdobramentos essenciais dessa vida afetiva bela e virtuosa no enredo profundo do qual emerge o afeto, a fé e a contradição da experiência humana do sofrimento amoroso. Palavras Chave: Literatura Medieval. Amor Cortês, André Capelão, virtude, desejo. Abstract: With the treaty toward the love - Tractatus de Amore – André Capelão offers to the reader the courteous’ art for love, the erotic desire’s beauty and the  suffering discipline belong this love’s art  is. The best reason of this literary composition is to achieve the depth sigh that the loving dimension infuses into the lovers’s soul, the man and the woman wich this virtue was conceded. For this author, the royal chancery scribe and perhaps, no one knows for sure, a Sacratus Ordo, love is the root of all free, the source of all good. Our goal, then, is to find this sum loving built in interlacing of Medieval Knights literature, the essential developments of this beautiful and virtuous love life in the deep storyline which emerges affection, faith and the contradiction of the human experience of love suffering. Key words: Medieval Literature. Courteous Love. André Capelão. Virtue.

  6. Remote Temperature Estimation in Intravascular Photoacoustic Imaging

    OpenAIRE

    Sethuraman, Shriram; Aglyamov, Salavat R.; Smalling, Richard W; Emelianov, Stanislav Y

    2007-01-01

    Intravascular photoacoustic (IVPA) imaging is based on the detection of laser-induced acoustic waves generated within the arterial tissue under pulsed laser irradiation. Generally, laser radiant energy levels are kept low (20 mJ/cm2) during photoacoustic imaging to conform to general standards for safe use of lasers on biological tissues. However, safety standards in intravascular photoacoustic imaging are not yet fully established. Consequently, monitoring spatio-temporal temperature changes...

  7. Intravascular brachytherapy for peripheral vascular disease

    OpenAIRE

    Hagen, Anja; Schönermark, Matthias P.; Dintsios, Charalabos-Markos; Gorenoi, Vitali

    2008-01-01

    Scientific background: Percutaneous transluminal angioplasties (PTA) through balloon dilatation with or without stenting, i.e. vessel expansion through balloons with or without of implantation of small tubes, called stents, are used in the treatment of peripheral artery occlusive disease (PAOD). The intravascular vessel irradiation, called intravascular brachytherapy, promises a reduction in the rate of repeated stenosis (rate of restenosis) after PTA. Research questions: The evaluation addre...

  8. Linfoma não Hodgkin gástrico Gastric non-Hodgkin Lymphoma

    Directory of Open Access Journals (Sweden)

    Renata O. Costa

    2010-02-01

    Full Text Available Os linfomas extralinfonodais representam aproximadamente 1/3 de todos os linfomas não Hodgkin (LNH e, embora possam ter início em qualquer tecido, mais frequentemente acometem o trato gastrointestinal, sendo o estômago o órgão responsável pela grande maioria dos casos. Os linfomas primários gástricos são comumente LNH, sendo representados em mais de 95% dos casos pelo linfoma difuso de grandes células B e pelo linfoma MALT (mucosa associated lymphoid tissue. De evolução indolente, o linfoma MALT destaca-se por ser um modelo de câncer secundário à estimulação antigênica crônica exercida por uma bactéria denominada Helicobacter pylori (HP. No outro polo, situa-se o linfoma difuso de células B (LDGCB, que, de patogênese duvidosa, pode tratar-se de uma transformação de LNH MALT ou ainda se caracterizar por um linfoma "de novo". Neste estudo, revisamos a literatura, enfatizando aspectos importantes à prática clínica destes linfomas.Extranodal lymphomas account for about 30% of all non-Hodgkin lymphomas (NHL, and although they can originate in any tissue, the gastrointestinal tract is the most commonly affected structure with the stomach being the most common subtype. Diffuse Large B cell lymphoma (DLBCL and MALT (mucosa associated lymphoid tissue lymphoma account for more than 95% of the cases of gastric lymphoma. The indolent development of MALT lymphoma stands out as it is a type of cancer subject to chronic antigen stimulation by the Helicobacter pylori bacteria. Conversely, diffuse large B cell lymphomas, whose pathogenesis is uncertain, can be a transformation from MALT NHL or perhaps a new type of lymphoma. In this study we carried out a review of the literature, stressing the key aspects of these lymphomas in the clinical practice.

  9. Linfoma de celulas B de la zona marginal extraganglionar del tejido linfoide asociado a mucosa (linfoma MALT de pulmón

    Directory of Open Access Journals (Sweden)

    Carlos Vergara-Uzcategui

    2014-09-01

    Full Text Available Los Linfomas Pulmonares Primarios son extremadamente raros (0,4% de los linfomas extraganglionares, y generalmente son de tejido linfoide asociado a mucosas (tipo MALT, con ocasionales linfomas de células grandes difusos. Los síntomas son inespecíficos, y casi la mitad de los pacientes son asintomáticos. Se presenta el caso de un paciente masculino de 56 años de edad, quien presentó durante 7 meses accesos diarios de tos seca, de predominio nocturno, asociados en el último mes a fiebre de 39ºC, disnea a medianos esfuerzos y expectoración verduzca. Los exámenes de laboratorio fueron normales. La radiografía de tórax mostró el mediastino ensanchado, un proceso en lóbulo medio con efecto atelectásico, y un nódulo en hemitórax izquierdo. La tomografía computarizada (TC torácica de alta resolución evidenció proceso alveolar derecho en lóbulo medio y un nódulo pulmonar izquierdo calcificado de tipo inespecífico. El estudio inmunohistoquímico de la biopsia pulmonar fue compatible con Linfoma de Células B de la zona marginal extraganglionar del tejido linfoide asociado a mucosa (Linfoma MALT de pulmón. La TC corporal y la Tomografía por Emisión de Positrones (PET evidenciaron importantes hallazgos complementarios para determinar la extensión de la enfermedad. El paciente se trato con quimioterapia y actualmente se encuentra en buenas condiciones, sin recidiva de la sintomatología. Dado lo infrecuente de la patología se presenta este caso y se hace una revisión de la literatura

  10. Dosimetric calculus in intravascular brachytherapy

    International Nuclear Information System (INIS)

    Among the cardiovascular diseases, the most common is acute myocardial infarction, which occurs because of the occlusion of one or more coronary arteries. Balloon angioplasty has been a popular treatment which is less invasive than surgeries involving revascularization of the myocardium, thus promising a better quality of life for patients. Unfortunately, the rate of restenosis (re-closing of the vessel) after balloon angioplasty is high (approximately 30-50% within the first year after treatment). Known as Intravascular Brachytherapy, the technique has been used with several radiation sources, and researchers have obtained success in decreasing the rate of restenosis. In order to study the radiation dosimetry in the patient and radiological protection for this therapy, radiation dose distributions for monoenergetic electrons and photons (at nine discrete energies) were calculated for blood vessels of diameter 0.15, 0.30 and 0.45 cm with balloon and wire sources using the radiation transport code MCNP4B. Specific calculations were carried out for several radionuclides. Two stent sources employing 32P are also simulated. Advantages and disadvantages of the radionuclides and source geometries are discussed and the dosimetry developed here will aid in the realization of the benefits obtained in patients. (author)

  11. Interventional and intravascular MR angiography

    International Nuclear Information System (INIS)

    Magnetic resonance imaging (MRI) has a number of characteristics which make it attractive for guidance of intravascular therapeutic procedures, including high soft tissue contrast, imaging in any arbitrary oblique plane, lack of ionizing radiation, and the ability to provide functional information, such as flow velocity and volume per unit time. For MR guidance of vascular interventions to be safe, catheters and guidewires must be visualized relative to the vascular system and surrounding tissues. A number of approaches for making instruments visible in an MR environment are presented, including both passive and active techniques. Passive techniques depend on contrast agents or susceptibility artifacts, whereas active techniques, including MR tracking, MR profiling, and active field inhomogeneity, use some form of electrical coil built into the instrument. The potential for obtaining high-resolution images of the vessel wall using coils built into a catheter is also discussed. These images provide the capability to distinguish and identify various plaque components. The additional capabilities of MRI could potentially open up new applications beyond those currently performed under X-ray fluoroscopic guidance. (orig.)

  12. Dosimetry in intravascular brachytherapy; Calculos dosimetricos em braquiterapia intravascular

    Energy Technology Data Exchange (ETDEWEB)

    Campos, Laelia Pumilla Botelho

    2000-03-01

    Among the cardiovascular diseases responsible for deaths in the adult population in almost all countries of the world, the most common is acute myocardial infarction, which generally occurs because of the occlusion of one or more coronary arteries. Several diagnostic techniques and therapies are being tested for the treatment of coronary artery disease. Balloon angioplasty has been a popular treatment which is less invasive than traditional surgeries involving revascularization of the myocardium, thus promising a better quality of life for patients. Unfortunately, the rate of restenosis (re-closing of the vessel) after balloon angioplasty is high (approximately 30-50% within the first year after treatment).Recently, the idea of delivering high radiation doses to coronary arteries to avoid or delay restenosis has been suggested. Known as intravascular brachytherapy, the technique has been used with several radiation sources, and researchers have obtained success in decreasing the rate of restenosis in some patient populations. In order to study the radiation dosimetry in the patient and radiological protection for the attending staff for this therapy, radiation dose distributions for monoenergetic electrons and photons (at nine discrete energies) were calculated for blood vessels of diameter 0.15, o,30 and 0.45 cm with balloon and wire sources using the radiation transport code MCNP4B. Specific calculations were carried out for several candidate radionuclides as well. Two s tent sources (metallic prosthesis that put inside of patient's artery through angioplasty) employing {sup 32} P are also simulated. Advantages and disadvantages of the various radionuclides and source geometries are discussed. The dosimetry developed here will aid in the realization of the benefits obtained in patients for this promising new technology. (author)

  13. Coagulación intravascular diseminada = Disseminated intravascular coagulation

    Directory of Open Access Journals (Sweden)

    Arango Barrientos, Marcos

    2010-12-01

    Full Text Available La coagulación intravascular diseminada (CID es una entidad clínica frecuente que se presenta como fenómeno secundario a diversas enfermedades entre las cuales se destacan las infecciones graves, las neoplasias y las catástrofes obstétricas. Se caracteriza por una activación difusa y simultánea de los sistemas endógenos de la coagulación y la fibrinólisis. El depósito de pequeños trombos en la circulación conduce finalmente a disfunción orgánica múltiple y en algunos casos a la muerte. Las manifestaciones clínicas pueden incluir fenómenos trombóticos y hemorrágicos. Se ha propuesto un puntaje de fácil aplicación para simplificar el diagnóstico de la entidad. El tratamiento incluye el control específico de la causa subyacente que favorece la aparición de la CID, el soporte con hemoderivados en pacientes con manifestaciones de sangrado y la anticoagulación terapéutica en pacientes con trombosis mayores. El desarrollo de CID es un factor pronóstico adverso que aumenta significativamente la tasa de mortalidad. En este artículo de revisión se incluyen los siguientes aspectos de la CID: historia, epidemiología, clasificación, entidades asociadas, fisiopatología, clínica, diagnóstico, tratamiento y pronóstico.

  14. The radiobiology of intravascular irradiation

    International Nuclear Information System (INIS)

    Purpose: There is increasing interest in the use of vascular irradiation, from an internally introduced radioactive source to control restenosis after balloon angioplasty. Both animal experiments and early clinical studies appear to show promising results in this regard. We consider various mechanistic interpretations of the experimental and clinical observations that doses of 12-20 Gy appear to be efficacious in preventing restenosis. We develop and investigate simple models, both experimental and theoretical, of the kinetics of radiation-induced smooth muscle cell (SMC) inactivation and regrowth, as a first step toward optimizing the design of clinical vascular irradiation. Methods and Materials: Using in vitro models of human SMCs, we investigate the relative radiosensitivity of SMCs compared with endothelial cells and measure the dose-dependent ability of SMCs to repopulate a denuded region in a confluent layer of cells. We then use quantitative information on the number, radiation sensitivity, and growth rate of the potential arterial target cells to model the time course of the SMC population after irradiation. Results and Conclusion: Doses >20 Gy, which would be required to completely eliminate the SMC population which has the potential to cause restenosis, are too large to be practical because of the unacceptable risk of late complications. However, doses that can be practically given in vascular irradiation (<20 Gy) will certainly delay restenosis by 1-3 years, with larger doses producing longer delays. Whether such doses can avert restenosis permanently is unclear, as permanent prevention at realistic doses depends critically on the assumption that those SMCs which survive irradiation have a significantly limited capacity for proliferation. With regard to current animal model experiments, routine follow-up of <1 year, which is standard practice, is probably too short to address some of the key mechanistic question in intravascular radiation therapy

  15. Tejido linfoide y linfomas gástricos Lymphoid tissue and gastric lymphomas

    Directory of Open Access Journals (Sweden)

    Rocío del Pilar López P

    Full Text Available En este artículo hemos realizado una amplia revisión de los linfomas primarios gástricos, su clasificación y aspectos clínico-patológicos más importantes, haciendo énfasis especial en los linfomas MALT o asociados a las mucosas y su relación con la infección por Helicobacter pylori.In this review we describe various aspects of the primary gastric lymphomas, the classification, and the most important clinico-pathological aspects, with emphasis in mucosa associated lymphoma (MALT and the Helicobacter pylori infection.

  16. Prediction of outcome after femoropopliteal balloon angioplasty by intravascular ultrasound

    DEFF Research Database (Denmark)

    Vogt, K C; Just, S; Rasmussen, John Bøje Grønvall; Schroeder, T V

    1997-01-01

    OBJECTIVE: To evaluate intravascular ultrasound (IVUS) as a control procedure after femoropopliteal percutaneous transluminal angioplasty (PTA), and compare it with arteriography. DESIGN: Descriptive study. MATERIAL: Arteriographic and intravascular ultrasound data obtained from 18 patients (20...

  17. 21 CFR 882.5150 - Intravascular occluding catheter.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Intravascular occluding catheter. 882.5150 Section... occluding catheter. (a) Identification. An intravascular occluding catheter is a catheter with an inflatable... December 26, 1996 for any intravascular occluding catheter that was in commercial distribution before...

  18. 21 CFR 870.1200 - Diagnostic intravascular catheter.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Diagnostic intravascular catheter. 870.1200... intravascular catheter. (a) Identification. An intravascular diagnostic catheter is a device used to record... this generic device are right-heart catheters, left-heart catheters, and angiographic catheters,...

  19. 21 CFR 880.5210 - Intravascular catheter securement device.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Intravascular catheter securement device. 880.5210... Therapeutic Devices § 880.5210 Intravascular catheter securement device. (a) Identification. An intravascular catheter securement device is a device with an adhesive backing that is placed over a needle or...

  20. Estudio histológico e inmunofenotípico de linfoma canino en el centro de México

    Directory of Open Access Journals (Sweden)

    Francisco J. Álvarez Berger

    2009-01-01

    Full Text Available El inmunofenotipo constituye un factor importante en el pronóstico del linfoma canino. Se ha demostrado que perros con linfoma de células B presentan tiempos de sobrevivencia más largos que los perros con linfoma de células T. Los antígenos CD3 y CD79a son los marcadores más utilizados en inmunohistoquímica para la determinación del fenotipo celular T y B, respectivamente, en muestras fijadas en formalina y conservadas en bloques de parafi na. En este estudio se describen las características morfológicas e inmunofenotípicas de 31 casos de linfoma en México, de casos del archivo del Departamento de Patología de la Facultad de Medicina Veterinaria y Zootecnia de la Universidad Nacional Autónoma de México. Para la clasificación histológica se utilizó el sistema del National Cancer Institute-Working Formulation (NCI-WF. Catorce casos (45.16% correspondieron a células B, 15 (48.39% a células T, y dos (6.45% fueron de origen indeterminado. Histopatológicamente, el linfoma difuso de células grandes fue el tipo más común, representó 38.71% de los casos; le siguieron los siguientes linfomas: linfocítico, inmunoblástico y linfoblástico. Los linfomas de grado intermedio a alto representaron 77.42% de los casos. En este estudio se encontró mayor prevalencia de linfoma de células T. Los resultados en este trabajo pudieran indicar una diferencia en la prevalencia en el inmunofenotipo del linfoma canino en México, en relación con otras zonas geográficas.

  1. Linfoma tonsilar em crianças com assimetria tonsilar / Tonsillar lymphoma in children with unilateral tonsillar enlargement / Linfoma tonsilar en niños con asimetría tonsilar

    Scientific Electronic Library Online (English)

    Alexandre Caixeta, Guimarães; Guilherme Machado de, Carvalho; Reinaldo Jordão, Gusmão.

    2012-06-01

    Full Text Available OBJETIVO: Demonstrar a importância do exame físico com ênfase nas alterações das tonsilas palatinas (TP) e na anamnese direcionada para a identificação precoce de pacientes com linfoma de TP. DESCRIÇÃO DO CASO: Caso 1 - Menina de cinco anos com voz abafada, observada pela mãe, e "sensação de algo es [...] tranho na garganta" há duas semanas. Foi atendida em outro serviço no início do quadro, sendo medicada com amoxicilina, sem melhora. Apresentava aumento importante da TP direita com superfície lisa e ausência de criptas. Após cirurgia, foi confirmado o diagnóstico de linfoma não Hodgkin (LNH). Na investigação também foi identificado acometimento dos linfonodos mesentéricos pelo linfoma. Caso 2 - Menina de 11 anos procurou o pronto-socorro para investigar nódulo em TP esquerda, indolor, de crescimento progressivo há um ano, sem outras queixas. Já havia passado por consultas médicas anteriores, não tendo sido valorizada a queixa da paciente. A TP esquerda encontrava-se aumentada, ultrapassando a linha média e com nódulo no polo superior. Também foi diagnosticado LNH após exame anatomopatológico. COMENTÁRIOS: Um exame minucioso da cavidade oral e do pescoço é essencial para identificar alterações suspeitas de linfoma tonsilar. Pacientes com assimetria tonsilar e outros achados sugestivos de malignidade devem ser submetidos à tonsilectomia. Abstract in spanish OBJETIVO: Demostrar la importancia de un examen físico con énfasis en las alteraciones de las tonsilas palatinas (TP) y en la anamnesis dirigida a la identificación temprana de pacientes con linfoma de TP. DESCRIPCIÓN DEL CASO: Caso 1 - Niña de cinco años, con voz velada, observada por la madre, y « [...] sensación de algo extraño en la garganta» hace dos semanas. Fue atendida en otro servicio en el inicio del cuadro, siendo medicada con amoxicilina, sin mejora. Presentaba aumento importante de la TP derecha con superficie lisa y ausencia de criptas. Después de la cirugía, se confirmó el diagnóstico de linfoma no Hodgkin (LNH). En la investigación también se identificó acometimiento de los nodos linfáticos mesentéricos por el linfoma. Caso 2 - Muchacha de 11 años buscó al servicio de urgencia para investigar nódulo en TP izquierda, indolora, de crecimiento progresivo hace un año, sin otras quejas. Ya había pasado por consultas médicas anteriores, no habiendo sido valorizada la queja de la paciente. La TP izquierda se encontraba aumentada, sobrepasando la línea media y con nódulo en el polo superior de esa. También se diagnosticó LNH después de examen anatomopatológico. COMENTARIOS: Un examen minucioso de la cavidad oral y del cuello es esencial para identificar alteraciones sospechosas de linfoma tonsilar. Pacientes con asimetría tonsilar y otros hallazgos sugestivos de malignidad deben ser sometidos a tonsilectomía. Abstract in english OBJECTIVE: To demonstrate the importance of a medical examination with emphasis on changes of the palatine tonsils (PT) and proper anamnesis to early identify patients with tonsillar lymphoma. CASE DESCRIPTION: Case 1 - 5-year-old girl with a muffled voice noted by her mother and a report of "feelin [...] g a strange sensation in the throat" for two weeks. She was previously treated in another service at the beginning of the symptoms with amoxicillin without improvement. An important increase in the right PT was noted, with smooth surface and absence of crypts. The diagnosis of non-Hodgkin lymphoma (NHL) was confirmed after surgery. On further investigation, positive mesenteric lymph nodes were noted. Case 2 - 11-year-old girl came to the emergency service to investigate a painless nodule in the left palatine tonsil with progressive growth for one year, without other complaints. She had previously undergone other medical consultations, but no importance was given to the patient's complaint. Oroscopy showed that the left PT was increased crossing the midline and with a nodule in the upper pole. Patient also had NHL. COMMENTS: A detailed examinat

  2. Linfoma T subcutâneo do tipo paniculite: relato de um caso acometendo paciente pediátrico

    OpenAIRE

    Noronha Lúcia; Medeiros Fabiola; Prevedello Luciano Monte Serrat; Martins Vanessa Dello Monaco; Watanabe Flora; Fillus Neto José

    2001-01-01

    Os autores relatam um caso de linfoma T subcutâneo do tipo paniculite em uma paciente feminina de 3 anos, apresentando havia um mês múltiplos nódulos subcutâneos, indolores, disseminados no abdome, região peitoral e cervical. Ao exame histopatológico, evidenciou-se um linfoma T infiltrando tecido adiposo subcutâneo. Os linfomas T subcutâneos representam uma entidade clinicopatológica distinta, sendo raro o acometimento pediátrico.

  3. Linfoma primário de cavidade pleural em paciente imunocompetente Primary effusion lymphoma in an immunocompetent patient

    Directory of Open Access Journals (Sweden)

    Leila Antonangelo

    2005-12-01

    Full Text Available O linfoma primário de cavidade é um tipo raro de linfoma não-Hodgkin que acomete principalmente pacientes imunocomprometidos e, mais raramente, pacientes imunocompetentes. Neste relato de caso são apresentados os achados clínicos e laboratoriais de um paciente imunocompetente com derrame pleural diagnosticado como linfoma primário de cavidade pleural.Primary effusion lymphoma is an unusual non-Hodgkin's lymphoma rarely seen in immunocompetent patients. Herein, we present clinical and biochemical data obtained from an immunocompetent patient diagnosed with primary effusion lymphoma.

  4. Estudio histológico e inmunofenotípico de linfoma canino en el centro de México

    OpenAIRE

    Francisco J. Álvarez Berger; Enrique Aburto Fernández; Gerardo Aristi Urista; Gilberto Chávez Gris

    2009-01-01

    El inmunofenotipo constituye un factor importante en el pronóstico del linfoma canino. Se ha demostrado que perros con linfoma de células B presentan tiempos de sobrevivencia más largos que los perros con linfoma de células T. Los antígenos CD3 y CD79a son los marcadores más utilizados en inmunohistoquímica para la determinación del fenotipo celular T y B, respectivamente, en muestras fijadas en formalina y conservadas en bloques de parafi na. En este estudio se describen las características ...

  5. Abscesso cerebelar tratado clinicamente: relato de caso

    Directory of Open Access Journals (Sweden)

    Vialogo Josué Guimarães Granha

    2001-01-01

    Full Text Available Apresentamos um caso de abscesso cerebelar secundário a otite média crônica, localizado no hemisfério cerebelar direito, em uma paciente pediátrica, que foi tratado clinicamente. Obtendo resolução sem necessidade de cirurgia. A antibioticoterapia foi escolhida segundo critérios da literatura para os agentes etiológicos mais prováveis. Discutimos a patogênese, histopatogênese, o quadro clínico, o diagnóstico e as formas de tratamento dos abscessos do sistema nervoso central.

  6. Reuso do efluente tratado na indústria curtidora

    Directory of Open Access Journals (Sweden)

    Karl Heinz Luersen

    2012-01-01

    Full Text Available Com o objetivo de avaliar a possibilidade de reúso do efluente líquido tratado de uma indústria curtidora, foi realizada esta pesquisa. O procedimento experimental comparou a produção de couros confeccionados com água potável, extraída de poçosartesianos, com couros produzidos a partir do efluente líquido final tratado. Para alcançar este objetivo, foram realizados testes físicose químicos através de análises em laboratório (análises químicas e de resistências físicas e avaliações organolépticas executadas porprofissionais do setor de couro (quanto a cor, firmeza de flor, enchimento e toque. A avaliação analítica e a das característicasorganolépticas não indicam diferenças representativas quando comparadas aos padrões de referência da ABNT de couros produzidos,permitindo, assim, concluir que o reúso de efluente tratado não altera a aparência dos artigos de couro.Abstract This research was carried out to evaluate the possibility of reuse of a tannery treated effluent. The experimental procedure compared the production of leather made by the use of drinking water, extracted from artesian wells, to leather produced by the use of the final treated liquid effluent. In order to achieve this goal, physic-chemical tests were carried out in laboratory (chemical and physical resistance analysis and leather industry professionals performed organoleptic evaluations (for color, grain firmness, filling and touch. The analytical evaluation and the organoleptic properties evaluation do not indicate a statistically significant difference when compared to ABNT reference standards of produced leathers, what allows the researchers to conclude that the reuse of treated effluent does not change the appearance of leather goods.

  7. Linfoma primario de hueso con afectación multicéntrica

    Directory of Open Access Journals (Sweden)

    Marcelo Graziadio

    2012-10-01

    Full Text Available El linfoma primario de hueso es una enfermedad infrecuente, que tiene una presentación y evolución diferente a los linfomas de otras localizaciones. Se presenta un caso de linfoma primario de hueso de localización craneana y esternal de rápido crecimiento. En su evolución, realizada la exéresis de la lesión primaria de calota, presentó aparición de nuevas lesiones de rápido crecimiento a nivel craneano y fémur y progresión de lesión preesternal que, con anatomía patológica de linfoma no Hodgkin difuso de células grandes B, inició R-CHOPP (ciclofosfamida, doxorrubicina, vincristina, prednisona y rituximab con rápida disminución de todas las lesiones sin evidencia de progresión al cabo de los seis ciclos.

  8. Efectos tardíos y el linfoma de Hodgkin en estadio inicial

    Science.gov (United States)

    Los pacientes con linfoma de Hodgkin en estadio inicial que recibieron varios fármacos de quimioterapia como único tratamiento, tenían más probabilidad de sobrevivir 12 años después que los pacientes que recibieron tratamiento que incluía radioterapia.

  9. Linfoma renal: espectro de imagens na tomografia computadorizada Renal lymphoma: spectrum of computed tomography findings

    Directory of Open Access Journals (Sweden)

    Carol Pontes de Miranda Maranhão

    2005-04-01

    Full Text Available O acometimento renal no linfoma é raro, uma vez que o rim não possui tecido linfóide. O envolvimento secundário é mais freqüente, ocorrendo em até um terço das autópsias dos portadores de linfoma. Alguns autores acreditam que esta seja a única forma de acometimento renal, questionando a existência do linfoma primário. O linfoma renal representaria metástases hematogênicas ou invasão direta do tumor ocorrendo no espaço perirrenal. A partir destes tipos de envolvimento decorrem as formas de apresentação do linfoma renal: múltiplos nódulos, massa solitária, invasão renal por doença retroperitoneal contígua, doença perirrenal e infiltração difusa. Neste trabalho são discutidas e apresentadas imagens destas diferentes formas de acometimento.Isolated renal lymphoma is rare due to the absence of lymphoid tissue in kidneys. Secondary involvement occurs more frequently and is reported in up to 1/3 of the autopsies of patients who died from lymphoma. Some authors believe this is actually the only existing form of renal lymphoma. The involvement of the kidney by lymphoma would occur through hematogenic metastasis or direct tumor invasion of the perirenal space. These different types of involvement determine the several forms of renal lymphoma presentation: multiple nodules, solitary mass, renal invasion from contiguous retroperitoneal disease, perirenal disease and diffuse infiltration. In this study the imaging findings features of the different forms of involvement are presented and discussed.

  10. Simultaneous occurrence of follicular lymphoma and mixed-cellularity Hodgkin's lymphoma: lymph node and extranodal involvement Ocorrência simultânea de linfoma folicular e linfoma de Hodgkin celularidade mista: envolvimento nodal e extranodal

    Directory of Open Access Journals (Sweden)

    Maria do Patrocínio F. Grangeiro

    2004-02-01

    Full Text Available An unusual and well-characterised case of composite lymphoma in the spleen and lymph node is presented. The simultaneous occurrence of mixed-cellularity Hodgkin's lymphoma (HL and follicular non-Hodgkin's lymphoma (NHL was demonstrated in a 66-year-old man admitted in our Service with anaemia, hepatosplenomegaly and multiple abdominal lymph nodes. The morphological study of the spleen and lymph node of the splenic hilum showed an infiltrate composed of two distinct neoplasias. The liver was involved by NHL infiltrate and the peripancreatic lymph node exhibited HL. The Reed-Sternberg (RS cells expressed CD 15 and CD 30, whereas the NHL cells presented standard immunohistochemical features of follicular lymphoma. To our knowledge, this is the fifth case report of concurrent spleen involvement by composite lymphoma. The incidence, clinicopathological and immunohistochemical features of this rare association are discussed.Os autores apresentam um caso raro e bem caracterizado de linfoma composto no baço e linfonodos. A ocorrência simultânea de um linfoma de Hodgkin e um linfoma não-Hodgkin foi demonstrada em um homem de 66 anos admitido com anemia, hepatosplenomegalia e múltiplos linfonodos abdominais. O estudo morfológico do baço e linfonodo do hilo esplênico mostrou infiltração por duas neoplasias distintas. O fígado estava envolvido por linfoma não-Hodgkin e o linfonodo peripancreático mostrava um linfoma de Hodgkin. As células de Reed-Sternberg (RS expressaram CD 15 e CD 30, enquanto as células do linfoma não-Hodgkin apresentaram os aspectos imunoistoquímicos clássicos do linfoma folicular. Na literatura médica, este é o quinto caso descrito de envolvimento do baço por linfoma composto. A incidência, aspectos clínicos e imunoistoquímicos desta rara associação são discutidos.

  11. Del tratado de la pintura de leonardo

    OpenAIRE

    Leonardo, da Vinci, 1452-1519, il; Ideas y Valores, .

    2011-01-01

    El "Tratado de la Pintura" de Leonardo es unarecopilación de un discípulo sobre notas del granMaestro. Publicado por primera vez en Paris en 1651,no contiene una verdadera teoría del arte, sino losmotivos en los cuales Leonardo se inspiró en su actividad artística.  Reproducimos a continuación partesque se refieren a la esencia de la pintura, la predilectaentre las artes por Leonardo, a su superioridadsobre la música y la escultura, y, en fin, a las cualidadesque debe tener el pintor.

  12. Abscesso cerebelar tratado clinicamente: relato de caso

    OpenAIRE

    Vialogo Josué Guimarães Granha; Sanches Maria Cristina Arrua

    2001-01-01

    Apresentamos um caso de abscesso cerebelar secundário a otite média crônica, localizado no hemisfério cerebelar direito, em uma paciente pediátrica, que foi tratado clinicamente. Obtendo resolução sem necessidade de cirurgia. A antibioticoterapia foi escolhida segundo critérios da literatura para os agentes etiológicos mais prováveis. Discutimos a patogênese, histopatogênese, o quadro clínico, o diagnóstico e as formas de tratamento dos abscessos do sistema nervoso central.

  13. Optimization of Stent Deployment by Intravascular Ultrasound

    OpenAIRE

    Yoon, Hyuck-Jun; Hur, Seung-Ho

    2012-01-01

    Intravascular ultrasound (IVUS) is a useful diagnostic method that provides valuable information in addition to angiography regarding the coronary vessel lumen, dimensions, plaque burden, and characteristics. The major use of IVUS in coronary intervention is to guide interventional strategies and assess optimal stent deployment. Since the introduction of the drug-eluting stent (DES), concerns about restenosis have decreased. However, high-risk lesion subsets are being routinely treated with D...

  14. Temporary intravascular shunts for peripheral vascular trauma.

    Directory of Open Access Journals (Sweden)

    Husain A

    1992-04-01

    Full Text Available Polyvinylchloride (PVC disposable endotracheal suction catheters were successfully used as temporary intravascular shunts in 5 patients of popliteal artery trauma. These simple shunts should be used routinely in such conditions to immediately re-establish blood supply to the ischaemic limb particularly in patients of polytrauma where systemic anticoagulation is contraindicated. This avoids the inherent delay prior to vascular repair and reduces the incidence of irreversible ischemia.

  15. Advancing intravascular ultrasonic palpation toward clinical applications.

    Science.gov (United States)

    Doyley, M M; Mastik, F; de Korte, C L; Carlier, S G; Céspedes, E I; Serruys, P W; Bom, N; van der Steen, A F

    2001-11-01

    This paper describes the first reported attempt to develop a real-time intravascular ultrasonic palpation system. We also report on our first experience in the catherization laboratory with this new elastographic imaging technique. The prototype system was based on commercially available intravascular ultrasound (US) scanner that was equipped with a 20-MHz array catheter. Digital beam-formed radiofrequency (RF) echo data (i.e., 12 bits, 100 Hz) was captured at full frame rate from the scanner and transferred to personal computer (PC) memory using a fast data-acquisition system. Composite palpograms were created by applying a one-dimensional (1-D) echo tracking technique in combination with global motion compensation and multiframe averaging to several pairs of RF echo frames that were obtained in the diastolic phase of the cardiac cycle. The quality of palpograms was assessed by conducting experiments on vessel phantoms and on patients. The results demonstrated that robust and consistent palpograms could be generated in almost real-time using the proposed system. Good correlation was observed between low strain values and regions of calcification as identified from the intravascular US (IVUS) sonograms. Although the clinical results are clearly preliminary, it was concluded that the prototype system performed sufficiently well to warrant further and more in-depth clinical investigation. PMID:11750745

  16. Intravascular papillary endothelial hyperplasia: report of two cases

    Energy Technology Data Exchange (ETDEWEB)

    Paunipagar, Bhawan K.; Rasalkar, Darshana D.; Ng, Alex; Griffith, James F. (Dept. of Imaging and Interventional Radiology, The Chinese Univ. of Hong Kong, Prince of Wales Hospital, Shatin, (Hong Kong)), email: darshana@cuhk.edu.hk; Bagaria, Vaibhav (Columbia Asia Hospital, Delhi (India))

    2011-06-15

    Intravascular papillary endothelial hyperplasia is a rare benign vascular proliferative process as a result of papillary proliferation of the endothelial cells within the vascular lumen. We report two cases of intravascular papillary endothelial hyperplasia affecting the extremities. The characteristic sonological and MR imaging features are discussed, with updated review of literature. Imaging features are helpful in achieving a definitive diagnosis of the intravascular papillary endothelial hyperplasia

  17. Ictericia obstructiva asociada a linfoma de Burkitt en un adulto inmunocompetente

    Directory of Open Access Journals (Sweden)

    Andrea Paissan

    2007-01-01

    Full Text Available El compromiso primario del páncreas en los linfomas es muy poco frecuente, sin embargo, en los estadios avanzados de los linfomas no Hodgkin la invasión secundaria de la glándula es observada con mayor frecuencia. El objetivo de esta presentación es describir un caso de linfoma de Burkitt en un adulto inmunocompetente que presentó como manifestación relevante colestasis extrahepática secundaria probablemente a infiltración pancreática difusa y tumores cutáneos cuya histología permitió hacer el diagnóstico. Luego de una dosis única de hidrocortisona de 100mg, mejoró la ictericia, disminuyeron las enzimas de colestasis, las lesiones cutáneas y disminuyó el tamaño del páncreas en la ecografía y en la tomografía computada. Existen en la literatura reportes aislados de casos de linfoma tipo Burkitt que se asocian a ictericia obstructiva secundaria y a infiltración pancreática o del hilio hepático, tratándose en su mayoría de casos pediátricos o de individuos afectados por el virus de la inmunodeficiencia humana (VIH. Creemos que el interés de este caso radica en la rápida respuesta a dosis bajas de corticoides de la colestasis, lo que evitó la necesidad de un procedimiento quirúrgico tanto diagnóstico como terapéutico de la obstrucción biliar, como está referido en la literatura, permitiendo instaurar rápidamente el tratamiento quimioterapéutico específico de esta entidad sin maniobras quirúrgicas o endoscópicas.

  18. Linfoma não-Hodgkin de órbita: relato de caso Non-Hodgkin orbital lymphoma: case report

    OpenAIRE

    Cristiane do Prado Silva; Maria Aparecida Domingues; Silvana Artioli Schellini; Ligia Niero

    2008-01-01

    O objetivo é relatar manifestação incomum de linfoma não-Hodgkin de órbita. Paciente masculino, de 75 anos, se apresentou com queixa de lacrimejamento crônico bilateral. Havia feito dacriocistorrinostomia endonasal à direita e à esquerda por duas vezes, sem sucesso. Ao exame, massas de consistência fibroelástica, em topografia das "bolsas" de gordura das pálpebras inferiores e proptose axial. O paciente negava outros sintomas ou sinais sistêmicos. Hemograma sem alteração, hormônios tireoidian...

  19. Linfoma não Hodgkin simulando hanseníase virchowiana

    OpenAIRE

    Rocha Vanessa Barreto; Carvalho Saôny Victor de; Araújo Marcelo Grossi; Guedes Antônio Carlos Martins

    2003-01-01

    Os autores relatam caso de linfoma não Hodgkin em paciente do sexo feminino, de 28 anos, ressaltando o diagnóstico diferencial com formas multibacilares de hanseníase. Além de achados clínicos passíveis de confusão, a histologia mostrava, de modo não usual, infiltrado inflamatório mononuclear perineural e perianexial.

  20. Quiloperitoneo como forma de presentación del linfoma intestinal difuso: Reporte de un caso

    Directory of Open Access Journals (Sweden)

    Oscar Pamo Reyna

    2007-07-01

    Full Text Available Mujer de 29 años que desarrolló insidiosamente ascitis y dolor abdominal. El estudio del líquido ascítico reveló su aspecto lechoso y de trasudado. El estudio tomográfico mostró un conglomerado ganglionar retroperitoneal. El CA 125 fue más de cien veces el límite superior normal. El estudio reveló que se trataba de un linfoma no Hodgkin intestinal difuso de células grandes, estirpe linfoide B.(Rev Med Hered 2007;18:155-160.

  1. T-lymphoblastic lymphoma in adults Linfoma linfoblástico-T em adultos

    Directory of Open Access Journals (Sweden)

    Gino Santini

    2009-08-01

    Full Text Available In this short opinion review we discuss recent aspects of T-lymphoma lymphoblastic adults, like the evolution of the knowledge of classification, prognostic factors and the patients management.Nesta breve revisão os autores apresentam diversos aspectos de evolução dos conhecimentos na classificação e no manuseio dos pacientes portadores de linfoma linfoblástico-T em adultos.

  2. Linfoma No Hodgkin, manifestaciones oftalmológicas: Presentación de 1 caso

    Directory of Open Access Journals (Sweden)

    Tomás Ramírez Castro

    2003-12-01

    Full Text Available Se presenta un paciente con Linfoma no Hodgkin linfocítico estadio IV y Retinosis Pigmentaria de base diagnosticado en el Centro de Referencia Nacional de Retinosis Pigmentaria, con manifestaciones oftalmológicas de esta neoplasia, remitido, además, al Instituto Nacional de Oncología y Radiobiología. Se ilustra con imágenes estas lesiones infrecuentes.

  3. Acantosis nigricans y linfoma no Hodgkin: presentación de un caso

    Directory of Open Access Journals (Sweden)

    Miguel Damián Junco Bonet

    2014-01-01

    Full Text Available Fundamento: la acantosis nigricans fue la primera dermatosis en la que se reconoció un carácter paraneoplásico. La característica sobresaliente es la hiperpigmentación simétrica y el engrosamiento aterciopelado de la piel. Se sugiere que algún factor producido por el tumor estimula el crecimiento epidérmico. Objetivo: presentar un caso poco frecuente de un paciente con el diagnóstico de linfoma no Hodgkin y acantosis nigricans. Caso clínico: se presenta el caso de un paciente masculino de 62 años de edad con antecedentes de hipertensión arterial que un año previo a su ingreso manifestó cambios en la coloración de la piel, dermatosis generalizada, hiperpigmentación e hiperqueratosis en las palmas de las manos y el cuello. Conclusiones: el tumor más frecuente asociado con acantosis es el adenocarcinoma abdominal en 90 % de los casos, entre los cuales 64 a 69 % son de origen gástrico; el resto (10 % se asocian con cáncer no digestivo; linfoma de Hodgkin, micosis fungoide, cáncer de esófago, próstata y tiroides. En el linfoma no Hodgkin su asociación es considerada muy rara y son pocos los casos reportados en la bibliografía.

  4. Hypothesis: Disseminated Intravascular Inflammation as the Inflammatory Counterpart to Disseminated Intravascular Coagulation

    Science.gov (United States)

    Bull, Brian S.; Bull, Maureen H.

    1994-08-01

    We have identified a leukocyte activation syndrome that is occasionally associated with the transfusion of intraoperatively recovered erythrocytes. This syndrome appears to result from intravascular damage caused by leukocytes activated during the erythrocyte salvage process. We hypothesize that this syndrome is part of a larger disease grouping: disseminated intravascular inflammation (DII). DII is the analog of the coagulation disorder disseminated intravascular coagulation. In disseminated intravascular coagulation, the organ damage results from uncontrolled activation of the clotting pathway; in DII the damage is caused by leukocytes that have become activated by direct contact with bacteria or in rare instances-such as erythrocyte salvage-in the absence of bacteria and bacterial products. Recent studies of the hazards associated with intraoperative blood salvage indicate that activation of leukocytes can be achieved by exposure to activated platelets alone. If such activated leukocytes are reinfused along with the washed erythrocytes, widespread organ damage may result. The lung is the organ most severely affected by activated leukocytes. Adult respiratory distress syndrome is one outcome. It is likely that DII is a presently unrecognized pathophysiological process that complicates a variety of primary disease states and increases their lethality.

  5. Linfoma conjuntival tipo MALT bilateral en adolescente / Bilateral Conjunctival MALT Lymphoma in an Adolescent

    Scientific Electronic Library Online (English)

    Hiram Luis, Mena Estévez; Mabel Marilín, Calderín López; Deysi Mayle, Oquendo Calderín; Hiram Alejandro, Mena Calderín; Diagnis, Rodriguez Verdecia.

    2014-03-01

    Full Text Available Los linfomas tipo MALT primarios de conjuntiva son infrecuentes y es mucho menor la afectación conjuntival exclusiva, su bilateralidad es poco común, representan el 5% del total de los linfomas no Hodgkin extranodales; son linfomas B de bajo grado derivados de linfocitos de la zona marginal con alte [...] raciones moleculares que han bloqueado su apoptosis. Se presentó un caso de linfoma tipo MALT primario de la conjuntiva tarsal inferior de ambos ojos, en un niño de 12 años de edad, que acudió por enrojecimiento y molestias en ambos ojos de un año de evolución. Al realizar el examen físico presentó discreta ptosis del ojo izquierdo de un milímetro, masa de color anaranjada-salmón en fondo saco conjuntival inferior en ambos ojos, no adherida a planos profundos. El rayo x de órbita y la tomografía axial de cráneo no arrojó alteraciones. Se realizó hematología completa, pruebas de coagulación, bioquímica elemental y toda la analítica fue normal. El estudio anatomopatológico reportó: infiltrado linfoide denso y extenso constituido por linfocitos pequeños, algunos de aspecto plasmocitoide, sin nucléolo y sin indentación, dichos datos sugieren proliferacion linfoide maligna. Se confirmó el diagnóstico de linfoma B de bajo grado de tipo MALT. Abstract in english The primary MALT lymphomas of the conjunctiva are uncommon, the conjunctival affection is less frequent, and its bilaterality is uncommon, representing 5% of all extranodal non- Hodgkin lymphomas. Low-grade B lymphomas derived from marginal zone lymphocytes with molecular alterations are those that [...] have blocked its apoptosis. A 12 -year- old patient with primary MALT type lymphoma of the lower tarsal conjunctiva of both eyes was presented in this paper. The patient was healthy and presented redness and discomfort in both eyes in a year of evolution. The physical examination showed discrete ptosis of the left eye of a millimeter. Mass of orange - salmon color in lower conjunctival sac of both eyes, not adhered to deep planes was observed. Orbital X-ray and cranial CT were unaltered. Complete hematology, coagulation tests, and all elemental analytical biochemistry were performed, the results were normal. The pathological study reported: dense and extensive infiltrate lymphoid, composed of small lymphocytes, some without nucleolus plasmacytoid appearance without indentation, these data suggested a malignant lymphoid proliferation. The diagnosis of low-grade B-cell lymphoma of MALT type was confirmed.

  6. Positron autoradiography for intravascular imaging: feasibility evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Shikhaliev, Polad M [Department of Radiological Sciences, University of California at Irvine, Irvine, CA 92697 (United States); Xu, Tong [Department of Radiological Sciences, University of California at Irvine, Irvine, CA 92697 (United States); Ducote, Justin L [Department of Radiological Sciences, University of California at Irvine, Irvine, CA 92697 (United States); Easwaramoorthy, Balasubramaniam [Department of Psychiatry and Human Behavior, University of California at Irvine, Irvine, CA 92697 (United States); Mukherjee, Jogeshwar [Department of Psychiatry and Human Behavior, University of California at Irvine, Irvine, CA 92697 (United States); Molloi, Sabee [Department of Radiological Sciences, University of California at Irvine, Irvine, CA 92697 (United States)

    2006-02-21

    Approximately 70% of acute coronary artery disease is caused by unstable (vulnerable) plaques with an inflammation of the overlying cap and high lipid content. A rupturing of the inflamed cap of the plaque results in propagation of the thrombus into the lumen, blockage of the artery and acute ischaemic syndrome or sudden death. Morphological imaging such as angiography or intravascular ultrasound cannot determine inflammation status of the plaque. A radiotracer such as 18F-FDG is accumulated in vulnerable plaques due to higher metabolic activity of the inflamed cap and could be used to detect a vulnerable plaque. However, positron emission tomography (PET) cannot detect the FDG-labelled plaques because of respiratory and heart motions, small size and low activity of the plaques. Plaques can be detected using a miniature particle (positron) detector inserted into the artery. In this work, a new detector concept is investigated for intravascular imaging of the plaques. The detector consists of a storage phosphor tip bound to the end of an intravascular catheter. It can be inserted into an artery, absorb the 18F-FDG positrons from the plaques, withdrawn from the artery and read out. Length and diameter of the storage phosphor tip can be matched to the length and the diameter of the artery. Monte Carlo simulations and experimental evaluations of coronary plaque imaging with the proposed detector were performed. It was shown that the sensitivity of the storage phosphor detector to the positrons of 18F-FDG is sufficient to detect coronary plaques with 1 mm and 2 mm sizes and 590 Bq and 1180 Bq activities in the arteries with 2 mm and 3 mm diameters, respectively. An experimental study was performed using plastic tubes with 2 mm diameter filled with an FDG solution, which simulates blood. FDG spots simulating plaques were placed over the surface of the tube. A phosphor tip was inserted into the tube and imaged the plaques. Exposure time was 1 min in all simulations and experiments. Experiments showed that detecting the coronary plaques using the proposed technique is possible. The proposed technique has the potential for fast and accurate detection of vulnerable coronary and other intravascular plaques.

  7. Positron autoradiography for intravascular imaging: feasibility evaluation

    International Nuclear Information System (INIS)

    Approximately 70% of acute coronary artery disease is caused by unstable (vulnerable) plaques with an inflammation of the overlying cap and high lipid content. A rupturing of the inflamed cap of the plaque results in propagation of the thrombus into the lumen, blockage of the artery and acute ischaemic syndrome or sudden death. Morphological imaging such as angiography or intravascular ultrasound cannot determine inflammation status of the plaque. A radiotracer such as 18F-FDG is accumulated in vulnerable plaques due to higher metabolic activity of the inflamed cap and could be used to detect a vulnerable plaque. However, positron emission tomography (PET) cannot detect the FDG-labelled plaques because of respiratory and heart motions, small size and low activity of the plaques. Plaques can be detected using a miniature particle (positron) detector inserted into the artery. In this work, a new detector concept is investigated for intravascular imaging of the plaques. The detector consists of a storage phosphor tip bound to the end of an intravascular catheter. It can be inserted into an artery, absorb the 18F-FDG positrons from the plaques, withdrawn from the artery and read out. Length and diameter of the storage phosphor tip can be matched to the length and the diameter of the artery. Monte Carlo simulations and experimental evaluations of coronary plaque imaging with the proposed detector were performed. It was shown that the sensitivity of the storage phosphor detector to the positrons of 18F-FDG is sufficient to detect coronary plaques with 1 mm and 2 mm sizes and 590 Bq and 1180 Bq activities in the arteries with 2 mm and 3 mm diameters, respectively. An experimental study was performed using plastic tubes with 2 mm diameter filled with an FDG solution, which simulates blood. FDG spots simulating plaques were placed over the surface of the tube. A phosphor tip was inserted into the tube and imaged the plaques. Exposure time was 1 min in all simulations and experiments. Experiments showed that detecting the coronary plaques using the proposed technique is possible. The proposed technique has the potential for fast and accurate detection of vulnerable coronary and other intravascular plaques

  8. Role of informed consent for intravascular contrast media

    International Nuclear Information System (INIS)

    To evaluate the usefulness of different degrees of informed consent for intravascular contrast media, the authors divided 100 patients into four groups: (1) informed consent with no information on intravascular contrast media, (2) simple written informed consent that detailed common risks, (3) detailed written informed consent that detailed all known risks, and (4) MD informed consent, during which a radiologist discussed all known risks of intravascular contrast media. Physician counseling time for group 4 averaged 11.4 minutes. On a postprocedure test about the common complications and risk factors of intravascular contrast media, the average scores were: group 1, 38.4%; group 2, 68.2%; group 3, 63.2%; and group 4, 69.8%. There was no statistical difference between groups 2-4 on the postprocedure test. If informed consent is to be used prior to intravascular contrast media administration, a simple written consent detailing the common risks and risk factors appears to be the best method

  9. Transfusión intrauterina intravascular

    Directory of Open Access Journals (Sweden)

    Freddy González Arias

    2006-06-01

    Full Text Available Objetivo: Evaluar los resultados de 90 transfusiones intrauterinas intravasculares realizadas en 45 fetos afectados por aloinmunización Rh. Método: Descripción del procedimiento de transfusiones intrauterinas intravasculares y presentación de la evaluación y seguimiento prospectivo de 90 transfusiones llevadas a cabo entre el período 1995- 2002. Ambiente: Unidad de Alto Riesgo del Servicio de Prenatal de la Maternidad “Concepción Palacios”. Caracas. Resultados: La edad promedio de las pacientes fue 25,8 años; se realizaron en promedio 2 transfusiones por paciente, con un mínimo de 1 y un máximo de 4; la mayoría de las pacientes tenían antecedentes de importancia como mortinato anterior e historia de enfermedad hemolítica; la principal indicación para realizar la el procedimiento fue la lectura de densidad óptica seguida por el hidrops fetal; la edad promedio para realizar la primera transfusión fue de 25,6 semanas con un mínimo de 20 semanas; los valores de hemoglobina fetal previa a la primera oscilaron entre 2 y 11,3 g/dL ascendiendo posterior a la transfusión a valores entre 5 y 15,3 g/dL; la sobrevida total fue de 69 % y al analizar sólo los fetos sin hidrops la sobrevida ascendió a 84,37 %. Conclusiones: La prevención con el uso de inmunoglobulina anti Rh D es definitivamente el mejor protocolo para evitar la anemia fetal por aloinmunización Rh, cuando se produce la enfermedad hemolítica intrauterina el mejor tratamiento es la reposición de sangre a través del cordón umbilical. En nuestro trabajo confirmamos que se debe adquirir una amplia experiencia en el manejo de las transfusiones intrauterinas para de esta forma prolongar la vida intrauterina y así alcanzar mayor madurez y probabilidad de sobrevida neonatal con menores riesgos y complicaciones.Objective: To present the results of 90 intrauterine intravascular transfusions performed in 45 Rh isoinmunized fetuses. Method: Description of the intrauterine intravascular transfusion´s procedure and presentation of evaluation and prospective floow up of 90 transfusions practiced from 1995 to 2002. Setting: High Risk Unit of Prenatal Service at Maternidad Concepción Palacios. Caracas. Results: The mean age of patients was 25.8 years; the number of transfusions ranged from one to tour (the mean was two; most patients had important records of fetal death and hemolytic disease; transfusion was mainly prescribed after optical density values followed by fetal hydrops. Gestational age for the first procedure was 25.6 weeks with a minimum of 20 weeks; fetal haemoglobin values prior to the first transfusion ranged between 2-11.3 g/dL increasing to 5-15.3 g/dL post transfusion. Total survival was 69 % and increased to 84.37 % in the nonhydropic group. Conclusion: Prevention using antiRhD inmunoglobulin is definitively the best protocol when avoiding fetal anaemia due to Rh isoimmunization. When intrauterine hemolytic disease occurs, blood transfusion through umbilical cord seems to be the best option. In our experience, we confirmed that the accumulation of experience in intrauterine intravascular transfusion is needed in order to extend intrauterine life and so achieve a higher neonatal outcome along with less risk and complications.

  10. Biópsia estereotáxica para linfomas primários do sistema nervoso central

    OpenAIRE

    Murilo S. Meneses; Brian P. O'Neill; Kelly, Patrick J.

    1992-01-01

    Os linfomas primários do SNC são raros, mas sua incidência tem aumentado nos últimos anos, Estes tumores frequentemente se localizam nos gânglios da base e tálamo ou se apresentam de forma multifocal. O tratamento atual para eles é a radioterapia, associada ou não a quimioterapia. Devido à sua extremamente baixa morbidade, a biópsia estereo-táxica é o método ideal para determinar o diagnóstico histológico em pacientes com suspeita de linfomas do SNC. Os autores apresentam estudo de 49 casos d...

  11. Wilms’ tumor with intravascular extension: A review article

    Science.gov (United States)

    McMahon, Suzanne; Carachi, Robert

    2014-01-01

    Intravascular extension of Wilms’ tumor is a well-recognized phenomenon. Intravascular extension into the vena cava occurs in only 4-8% of patients with Wilms’ tumors and intraatrial extension occurs in around 1-3% of patients. This review of the published literature in this cohort aims to summarize the findings of different case series to provide an optimum management plan. A literature search was performed and index papers were retrieved for review. The search included the following terms: Intracaval, intravascular, intraatrial and intracardiac extension of Wilms’ tumor or nephroblastoma. The management of patients with intravascular tumor thrombus in Wilms’ tumor is complex. A skilled multi-disciplinary team at a tertiary referral center with cardiothoracic surgery available should manage these patients. Multi-modal diagnostic and preoperative imaging are required to confirm and define the extent of the extension. Preoperative chemotherapy is advocated for all but exceptional circumstances and must be followed closely. Surgical resection should be planned according to the stage of intravascular extension with possible need for cardiopulmonary bypass and deep hypothermia with cardiac arrest if required. Surgical complications are more common in this group of patients, but outcome is comparable to those without intravascular extension, and is more closely correlated with the histological subtype then stage of intravascular extension. Operative imaging are required to confirm and define the extent of the extension. PMID:25336800

  12. Wilms' tumor with intravascular extension: A review article.

    Science.gov (United States)

    McMahon, Suzanne; Carachi, Robert

    2014-10-01

    Intravascular extension of Wilms' tumor is a well-recognized phenomenon. Intravascular extension into the vena cava occurs in only 4-8% of patients with Wilms' tumors and intraatrial extension occurs in around 1-3% of patients. This review of the published literature in this cohort aims to summarize the findings of different case series to provide an optimum management plan. A literature search was performed and index papers were retrieved for review. The search included the following terms: Intracaval, intravascular, intraatrial and intracardiac extension of Wilms' tumor or nephroblastoma. The management of patients with intravascular tumor thrombus in Wilms' tumor is complex. A skilled multi-disciplinary team at a tertiary referral center with cardiothoracic surgery available should manage these patients. Multi-modal diagnostic and preoperative imaging are required to confirm and define the extent of the extension. Preoperative chemotherapy is advocated for all but exceptional circumstances and must be followed closely. Surgical resection should be planned according to the stage of intravascular extension with possible need for cardiopulmonary bypass and deep hypothermia with cardiac arrest if required. Surgical complications are more common in this group of patients, but outcome is comparable to those without intravascular extension, and is more closely correlated with the histological subtype then stage of intravascular extension. Operative imaging are required to confirm and define the extent of the extension. PMID:25336800

  13. Recurrence of peripheral T-cell lymphoma as granulomas in the lower limbs Granulomas epitelióides cutâneos, como manifestação de recidiva de linfoma de células T periférico

    Directory of Open Access Journals (Sweden)

    Ana Rita Travassos

    2012-10-01

    Full Text Available The presence of granulomas in the skin of T-cell lymphoma patients is a rare but well-known phenomenon. The authors present the case of a 44-year-old Caucasian male, with a previously treated peripheral T-cell lymphoma, with cutaneous infiltration and extensive dyschromia on his lower limbs. Skin biopsies revealed the presence of sarcoid granulomas associated with the recurrence of the lymphoma, confirmed by immunostaining and molecular analysis. Although a new scheme of chemotherapy was started, he died 18 months later. There are two different patterns of skin granulomas associated with lymphoma: granulomatous infiltrates admixed with neoplastic cells and cutaneous granulomas constituting a nonspecific manifestation of the underlying lymphoma, but presently there is no evidence supporting their relationship with lymphoma prognosis.A presença de granulomas cutâneos associados a linfomas é um fenômeno raro, mas bem conhecido. Um homem, 44 anos de idade, com diagnóstico prévio de linfoma de células T periférico, foi enviado à nossa consulta por infiltração cutânea e extensa discromia nos membros inferiores. A biopsia cutânea revelou a presença de granulomas epitelioides associados à recidiva do linfoma, confirmada pela marcação imuno-histoquímica e estudo molecular. Apesar de iniciado novo esquema de quimioterapia, o doente faleceu 18 meses depois. Na literatura são descritos dois tipos de granulomas cutâneos na presença de linfomas: associados à infiltração cutânea pelo linfoma ou como uma manifestação não específica do linfoma. Contudo, atualmente não há evidência que suporte a sua relação com o prognóstico dos linfomas.

  14. Actualidad clínica-biológica de los linfomas T cutáneos

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    María E. Faxas García

    2003-03-01

    Full Text Available Los linfomas cutáneos resultan modelos útiles para el estudio de los mecanismos patogénicos de las enfermedades linfoproliferativas dado que para el diagnóstico y el seguimiento, las muestras de tejido se obtienen a través de métodos no invasivos. Aunque los linfomas T cutáneos se desarrollan a partir de los linfocitos T residentes en la piel, otras células y diversos factores asociados al tejido linfoide participan en la linfomagénesis. La aparición de estos linfomas en la piel no excluye la presencia de células malignas en la circulación y su desarrollo en otros órganos. Actualmente, la posibilidad de detectar las lesiones en estadios tempranos y la precisión de alteraciones en el receptor de células T permite ampliar el estudio de esta enfermedad.The cutaneous lymphomas are useful models for studying the etiopathogenic mechanisms of the lymphoproliferative diseases, since the samples of tissue are obtained through non invasive methods for the diagnosis and follow-up. Although the cutaneous T-cell lymphomas are developed from the T lymphocytes existing in the skin, other cells and diverse factors associated with the lymphoid tissues take part in the lymphomagenesis. The appearance of these lymphomas in the skin does not exclude the presence of malignant cells in the circulation and their development in other organs. Nowadays, the possibility of detecting the injuries in early stages and the accuracy of alterations in the T-cell receptor allows to extend the study of this disease.

  15. LINFOMA CUTÁNEO DE CÉLULAS B TIPO CENTRO FOLICULAR CON INFILTRACIÓN A MÉDULA ÓSEA: REPORTE DE UN CASO LINFOMA CUTÂNEO DE CÉLULAS B TIPO CENTRO FOLICULAR COM INFILTRAÇÃO NA MEDULA ÓSSEA PRIMARY CUTANEOUS FOLLICLE CENTER LYMPHOMA WITH BONE MARROW INFILTRATION: RELATÓRIO DE UM CASO

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    CLAUDIA MARCELA ARENAS SOTO

    2012-06-01

    Full Text Available Los linfomas cutáneos primarios de células B constituyen cerca del 2025% de todos los linfomas. El linfoma cutáneo primario de células B tipo centro folicular es el subtipo más frecuente y se manifiesta principalmente en pacientes adultos con una edad media de 58 años (1, la diseminación extracutánea es muy rara y se presenta con nódulos, tumores o placas solitarios o en grupo usualmente localizados en cabeza o tronco. Presentamos el caso de una paciente con un linfoma primario cutáneo tipo centro folicular con infiltración a médula ósea.Os linfomas cutâneos primários de células B constituem cerca de 20 a 25% de todos os linfomas. O linfoma cutâneo primário de células B tipo centro folicular é o subtipo mais frequente e manifestase principalmente em pacientes adultos com uma idade média de 58 anos (1, a disseminação extracutânea é muito rara e apresentase com nódulos, tumores ou placas solitárias no grupo usualmente localizados na cabeça ou tronco. Apresentamos o caso de uma paciente com um linfoma primário cutâneo tipo centro folicular com infiltração na medula óssea.Primary B cell cutaneous lymphomas represent approximately 2025% of all lymphomas. Primary cutaneous follicle center lymphoma is the most common subtype occurring in adults with a mean age of 58 years. The disease typically presents with solitary plaques or nodules and is usually located in the head or trunk. Extra cutaneous dissemination is extremely rare. We present a case of a patient with primary cutaneous follicle center lymphoma with bone marrow infiltration.

  16. Ventricular metastasis resulting in disseminated intravascular coagulation

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    Davis Ian D

    2005-05-01

    Full Text Available Abstract Background Disseminated Intravascular Coagulation (DIC complicates up to 7% of malignancies, the commonest solid organ association being adenocarcinoma. Transitional Cell Carcinoma (TCC has rarely been associated with DIC. Case presentation A 74-year-old woman with TCC bladder and DIC was found to have a cardiac lesion suspicious for metastatic disease. The DIC improved with infusion of plasma and administration of Vitamin K, however the cardiac lesion was deemed inoperable and chemotherapy inappropriate; given the patients functional status. We postulate that direct activation of the coagulation cascade by the intraventricular metastasis probably triggered the coagulopathy in this patient. Conclusion Cardiac metastases should be considered in cancer patients with otherwise unexplained DIC. This may influence treatment choices.

  17. Intravascular Ultrasound Image Segmentation Using Morphological Snakes

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    Hamdi Mohamed Ali

    2012-06-01

    Full Text Available From the first use of the technics of intravascular ultrasound (IVUS as an imaging technique for the coronary artery system at the 70th century until now , the segmentation of the arterial wall boundaries still an important problem . Much research has been done to give better segmentation result for better diagnostics , evaluation and therapy planning. In this paper we present a new segmentation technics based on Morphological Snakes which developed by Luis Álvarez used for the first time for IVUS segmentation. It is a simple , fast and stable approach of snakes evolution algorithm. Results are presented and discussed in order to demonstrate the effectiveness of this approach in IVUS segmentation.

  18. Wilms tumor with intravascular tumor thrombus.

    Science.gov (United States)

    Emir, Suna

    2014-01-01

    Wilms tumor (WT) is one of the most common solid tumors in children. It is the second most common extracranial solid tumor after neuroblastoma. WT has a strong tendency to invade blood vessels in the form of tumor thrombus, into the renal veins, and inferior vena cava and even into the right atrium. Extension of tumor thrombus along to the renal vein into the inferior vena cava occurs in 4-10% of all patients. Tumor thrombus extending to the right atrium is less reported as 0.7-1%. WT with renal vein thrombus has been reported to be more common in the right kidney because of the shorter right renal vein. Most patients with tumor thrombus are asymptomatic and diagnosis is only made on imaging investigations. Several imaging modalities including computed tomography (CT), magnetic resonance imaging (MRI) and Doppler ultrasonography (USG) can demonstrate intravascular tumor thrombus before surgery. In addition to CT and MRI, Doppler USG is reliable in demonstrating the presence and extent of inferior vena cava tumor thrombus. The management of WT with tumor thrombus is determined by multiple factors such as extent of tumor thrombus, chemotherapy response of the tumor. Now, it is generally recommended to use preoperative chemotherapy to a patient presenting with intravascular tumor thrombus. This approach is helpful to decrease the extent of the vascular thrombus which facilitates surgical excision. Most intracaval and intraatrial thrombi in WT show a response to chemotherapy. Neoadjuvant chemotherapy causes tumor regression in nearly half of the patients. Most of them can be managed without the need for cardiac bypass surgery. The decision of initial surgery or preoperative chemotherapy should be carefully determined on every case. Primary surgery would only be indicated in a patient who is unstable because of thrombus that might dislodge and cause acute symptoms. Presence of tumor thrombus in WT needs for multidisciplinary care including pediatric oncologists, pediatric surgeons, and pediatric cardiac surgeons. PMID:26835320

  19. Linfoma cutáneo de células B grande de las piernas: presentación de un caso

    OpenAIRE

    Idalmis Campollo Rodríguez; Mauricio Socarrás Laborda; Patricia Alejandra Castro Sánchez

    2011-01-01

    Introducción: los linfomas cutáneos primarios de células B se definen como una proliferación neoplásica de células B que se originan en la piel. El linfoma de células B grande de las piernas, es un linfoma agresivo con un predominio de células B grande que se presenta en las extremidades inferiores. Existen múltiples clasificaciones con diferentes nomenclaturas; debido a la accesibilidad de la piel resulta relativamente sencillo tomar una biopsia, con lo que se obtienen muestras de lesiones p...

  20. Esquistossomose: 1.000 pacientes tratados

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    Pedro Aquino Noleto

    1974-12-01

    Full Text Available Os autores relatam sua experiência com o hycanthone em 1.000 pacientes de esquistossomose mansônica, até agora tratados no Hospital de Clínicas da Universidade do Estado da Guanabara. São pacientes oriundos de áreas endêmicas do País, especialmente do nordeste e sudeste, 53,9% do sexo masculino e 46,1% do sexo feminino, de idade entre 5 e 63 anos. A forma clínica predominante da parasitose foi a hépato-intestinal (96,8%. O medicamento foi administrado em dose única, na razão de 3 mg/kg de peso corporal, a 33.6% de pacientes internados e a 66 4% em regime de tratamento ambulatorial. Os níveis séricos das transaminases, determinados, para confronto, antes e depois do uso do produto, em 60 dos pacientes internados, não se alteraram, ou apenas sofreram elevações inexpressivas. Não houve efeitos colateriais em 42,3% dos pacientes. Nos demais, esses efeitos foram de pequena e média intentidade, duraram apenas o 19 dia, na maioria das vezes, e consisfram, especialmente, de náuseas e de vômitos. O controle de cura parasitária estabelecido compreendeu 4 exames de fezes - aos 30, 60, 90 e 120 dias do emprego do medicamento, o que já se fez em 330 pacientes (33%, com 99% de cura. Incluída a biópsia retal, sempre que foi possivel, por ocasião do 4º exame de fezes, o esquema funcionou até agora em 97 pacientes (9,7%, dos quais 92 (94% estão curados, segundo esse critério. O presente trabalho confirma a ação esquistossomicida do hycanthone, bem como sua boa tolerabilidade, inclusive no que se refere ao hepatócito. Os doentes, entretanto, devem ser criteriosamente selecionados, tendo-se em vista as contra-indicações conhecidas, de modo especial em relação ao fígado.

  1. The reproducibility of intravascular ultrasound imaging in vitro.

    OpenAIRE

    Moriuchi, M; Tobis, JM; Mahon, D.; Gessert, J; Griffith, J.; MCRAE, M; Moussabeck, O; HENRY, WL

    1990-01-01

    To determine which factors may affect the image quality when an intravascular ultrasound catheter is used in vivo, the influence of blood, temperature change, and contrast media were evaluated. In addition, to confirm the reproducibility of intravascular ultrasound imaging to measure cross-sectional lumen area, intraobserver and interobserver variability were determined. The findings indicated that ultrasound images in blood are mildly attenuated, that changes from room temperature to body te...

  2. Wilms’ tumor with intravascular extension: A review article

    OpenAIRE

    McMahon, Suzanne; Carachi, Robert

    2014-01-01

    Intravascular extension of Wilms’ tumor is a well-recognized phenomenon. Intravascular extension into the vena cava occurs in only 4-8% of patients with Wilms’ tumors and intraatrial extension occurs in around 1-3% of patients. This review of the published literature in this cohort aims to summarize the findings of different case series to provide an optimum management plan. A literature search was performed and index papers were retrieved for review. The search included the following terms: ...

  3. Linfoma primario del sistema nervioso central en una paciente con lupus eritematoso sistémico

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    C. N. Pisoni

    2003-06-01

    Full Text Available Se presenta una paciente de 36 años con diagnóstico de lupus eritematoso sistémico tratada con prednisona y ciclofosfamida que se internó por cefalea, hemiparesia y hemianestesia braquiocrural derecha de dos semanas de evolución. Se realizó una tomografía computada y una resonancia magnética nuclear de cerebro que mostraron una lesión nodular frontal izquierda. Se efectuó una biopsia a cielo abierto de la lesión cerebral cuyo diagnóstico histopatológico fue linfoma B de celulas grandes, difuso. Se inició radioterapia, no completó el tratamiento por complicaciones y falleció. Son muy pocos los casos publicados de linfoma primario del sistema nervioso central asociado a lupus eritematoso sistémico.A 36 year-old woman with systemic lupus erythematosus was admitted to our hospital with headache, brachiocrural hemiparesis and hemianesthesia. She had been treated with prednisone and cyclophosphamide. CT scan and MRI revealed a 15 mm nodular mass enhanced with gadolinium in left frontal convexity. CNS biopsy was performed and a diffuse large B-cell lymphoma was diagnosed. She was treated with radiation therapy without response and died. There are few reports of erythematosus systemic lupus associated with primary central nervous system lymphoma.

  4. Caracterización de factores pronósticos en pacientes con linfoma B difuso de células grandes

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    Natalia María Guevara

    2014-04-01

    Full Text Available Objetivo: describir los factores pronósticos demográficos, clínicos, hematológicos, inmunohistoquímicos y bioquímicos al diagnóstico de pacientes con linfoma B difuso de células grandes y su asociacióncon la severidad según el Índice Pronóstico Internacional en un Hospital Universitario, 2009-2012. Métodos: se realizó un estudio descriptivo en 40 pacientes con dicho linfoma. Se comparó laconcentración de ?2 microglobulina con los factores pronósticos que componen el IPI y otros que nohacen parte; se determinó la asociación entre el IPI e IPI revisado y la concentración de ?2 microglobulina,infiltración medular, masa voluminosa y expresión de BCL-2 y Ki-67. La información se analizó en SPSS. Resultados: 40% de los pacientes pertenecían al grupo de riesgo alto según el IPI y 55% al grupocon pronóstico pobre según el IPI revisado; 82.5% expresaron BCL-2 y 61.5% tenían un Ki-67>70%.Se observó asociación entre la ?2 microglobulina y el Ann Arbor (p=0.036, la ?2 microglobulina y lainfiltración medular (p=0.003, y la ?2 microglobulina y el IPI revisado (p=0.037. Conclusiones: es probable que el tiempo transcurrido entre la aparición de los síntomas y eldiagnóstico haya favorecido que los pacientes se presentaran en estados avanzados de la enfermedady como consecuencia, con un pronóstico pobre. Así mismo, el estudio de la infiltración medular, elporcentaje de expresión de Ki-67 y la concentración de ?2 microglobulina favorece a la identificaciónde pacientes con un pronóstico adverso. (Acta Med Colomb 2014: 39: 137-147.

  5. Hepatitis C: crioglobulinemia y linfoma no-Hodgkin Hepatitis C: cryoglobulinemia and non-Hodgkin lymphoma

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    M. Romero-Gómez

    2008-03-01

    Full Text Available La infección por el virus de la hepatitis C juega un papel principal en la patogénesis de la crioglobulinemia mixta, promoviendo la activación y expansión de las células B. Estos reajustes moleculares inducen la síntesis de crioglobulinas y la aparición de la vasculitis crioglobulinémica. El aclaramiento del virus provoca la resolución de las manifestaciones clínicas y de las alteraciones inmunológicas observados en la crioglobulinemia mixta en un alto porcentaje de los pacientes, pero no en todos. En algunos casos, la crioglobulinemia puede aparecer tras la respuesta virológica sostenida. Muchos mecanismos de la patogénesis de la crioglobulinemia mixta están fuertemente relacionados con la infección por VHC y, cuando el virus es eliminado, hay una mejoría en el curso de la enfermedad. Aun así, los pasos independientes relacionados con otros factores no mejoran tras la erradicación del virus. En algunos tipos de linfomas no-Hodgkin de bajo grado (linfoma linfoplasmocítico y linfoma de la zona marginal la respuesta sostenida tras el aclaramiento viral induce una remisión de la neoplasia. El VHC tiene un papel secundario en los linfomas agresivos y el aclaramiento del virus puede no inducir la remisión, pero puede disminuir la hepatotoxicidad asociada a la quimioterapia. Por tanto, en la hepatitis C crónica, la combinación de interferón pegilado y ribavirina es altamente recomendable en el tratamiento de la crioglobulinemia mixta sintomática y los linfomas no-Hodgkin asociados al VHC.Hepatitis C virus infection plays a major role in the pathogenesis of mixed cryoglobulinemia, promoting activation and expansion of B cells. These molecular rearrangements induce synthesis of cryoglobulins and the appearance of cryoglobulinemic vasculitis. Clearance of the virus promotes resolution of the clinical manifestations and immunological disorders seen in mixed cryoglobulinemia in a large percentage of patients, but not in all. In some cases, cryoglobulinemia could appear after sustained response. Several steps in the pathogenesis of mixed cryoglobulinemia are strongly related to HCV infection and when the virus is eliminated, the disease course improves. However, independent steps related to other factors do not improve following viral clearance. In some types of low-grade non-Hodgkin lymphoma (lymphomoplasmocytic lymphoma, marginal zone lymphoma sustained response following antiviral treatment induces remission of the neoplasm. HCV has a minor role in aggressive lymphomas and clearance of the virus may not induce remission, but could decrease the hepatotoxicity associated with the chemotherapy. Therefore, in chronic hepatitis C, the combination of peginterferon + ribavirin is strongly recommended in treating symptomatic mixed cryoglobulinemia and HCV-related non-Hodgkin lymphomas.

  6. Risk stratification for indolent lymphomas Estratificação de risco dos linfomas indolentes

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    Abrahão Elias Hallack Neto

    2010-01-01

    Full Text Available Indolent B-cell lymphomas account for approximately 40% of all non-Hodgkin lymphomas (NHLs. Advances in technology have contributed to improvements in the diagnosis and classification of indolent non-Hodgkin lymphomas. Follicular Lymphomas are the most common although the frequency varies significantly throughout the world. The description of the Follicular Lymphoma International Prognostic Index (FLIPI was an important step in identifying patient subgroups, but its use in the clinical practice has not been established yet. The use of a larger number of paraffin active monoclonal antibodies for immunohistochemistry, molecular cytogenetic studies including standard cytogenetics, multi-color fluorescence in-situ hybridization (FISH, polymerase chain reaction and locus-specific fluorescence insitu hybridization as well as developments in high-resolution techniquesincluding microarray gene expression profiling allow more accurate diagnosis andprecise definition of biomarkers of value in risk stratification. The identification ofdiseasespecific gene lists resulting from expression profiling provides a number ofpotential protein targets that can be validated using immunohistochemistry. Analysesof gene expression profiles or constitutive gene variations may also provide additional insight for prognostication in the near future. A comprehensive understanding of the biology of these distinct lymphoid tumors will allow us to identify novel diseaserelated genes and should facilitate the development of improved diagnosis, outcome prediction, and personalized approaches to treatment.Os linfomas de células B indolentes representam aproximadamente 40% do total de linfomas não Hodgkin (LNHs. O avanço das tecnologias novas tem contribuído para a melhora no diagnóstico e classificação dos LNH indolentes. O linfoma folicular é o mais comum e sua frequência varia significantemente pelo mundo. Adescrição do Índice Internacional de Prognóstico dos linfomas folicular (FLIPI representa um passo importante na identificação de subgrupos de pacientes, mas seu uso na prática clínica ainda necessita ser estabelecido. O uso de um número maior de anticorpos monoclonais para imunoistoquímica, estudo citogenético incluindo citogenética convencional ou hibridização in-situ por fluorescência (FISH, bem como o desenvolvimento de técnicas de alta resolução incluindo a expressão por microarray possibilita maior acurácia no diagnóstico e definição precisa dos biomarcadores com valor na estratificação de risco. A identificação de genes específicos para os diversos tipos de linfomas permite o reconhecimento de potenciais proteínas alvo que podem ser validadas usando imunoistoquímica. Análises da expressão do perfil de genes ou variações genéticas constitutivas pode também prover conhecimentos adicionais para o prognóstico em um futuro próximo. Um entendimento da biologia desses distintos tumores linfoides permite-nos identificar novos grupos de genes relacionados à doença e deve facilitar o desenvolvimento diagnóstico, predizendo a evolução e permitindo tratamentos personalizados.

  7. Espectroscopia y difusión por resonancia magnética para la caracterización del linfoma del sistema nervioso central

    Scientific Electronic Library Online (English)

    M., Migliaro; C., Besada.

    2014-12-01

    Full Text Available Objetivo: Mostrar los hallazgos de la resonancia magnética (RM) de cerebro, convencional y con técnicas funcionales (difusión y espectroscopia), del linfoma del sistema nervioso central (SNC), haciendo énfasis en los aportes que permiten aproximarse al diagnóstico y diferenciar la entidad de otros t [...] umores. Materiales y métodos: Desde junio de 2008 hasta enero de 2012, se estudiaron 26 pacientes inmunocompetentes con diagnóstico de tumor del SNC, confirmado por anatomía patológica. En todos los casos se realizó, antes de la cirugía o de la toma de biopsia, una RM convencional de cerebro con gadolinio y técnicas funcionales. Resultados: Se incluyeron 26 pacientes inmunocompetentes: 13 hombres y 13 mujeres. Ocho tuvieron diagnóstico de linfoma primario del SNC y los 18 restantes presentaron otros tumores: glioblastoma con centro necrótico (n= 9), oligoastrocitoma anaplásico (n= 3), metástasis con necrosis (n=4) y meduloblastoma (n=2). De las 26 lesiones, 10 (8 linfomas y 2 medublastomas) mostraron restricción de la difusión, en coincidencia con la alta celularidad tumoral de ambas entidades histológicas. En el análisis espectral de los tumores, todos tuvieron un incremento de la curva de lípidos. El pico en los linfomas y meduloblastomas ocurrió en los sitios sólidos, mientras que en las demás lesiones los lípidos se observaron en los sitios de necrosis tumoral. Conclusión: El análisis de las secuencias de RM convencional sin y con contraste endovenoso, junto con las técnicas de difusión y espectroscopia, permite aproximarse al diagnóstico de linfoma de SNC. Abstract in english Purpose: To show the imaging findings in cases of central nervous system (CNS) lymphoma with conventional and functional (diffusion and spectroscopy) magnetic resonance imaging (MRI) techniques, emphasizing the contributions that advanced imaging techniques provides to improve the diagnostic accurac [...] y and rule out other tumors. Materials and methods: Between June 2008 and January 2012 we studied 26 inmunocompetent patients with diagnosis of central nervous system tumor, confirmed by pathology. These patients performed a brain MRI with conventional and functional techniques (diffusion and spectroscopy) and with gadolinium before surgery or biopsy. Results: We included 26 inmunocompetent patients, 13 men and 13 women. Eight patients with diagnosis of primary CNS lymphoma and 18 with other tumors: glioblastoma (n=9), anaplastic oligoastrocytoma (n=3), metastases with necrosis (n=4), and medulloblastoma (n=2). Ten of the 26 lesions showed restricted diffusion, this happened in all lymphomas and in both medulloblastomas. This is due to the high cellularity of the tumors. Spectroscopy showed increased lipids in all tumors. The difference among the tumors was the place of the measurement of lipids. Both medulloblastoma and lymphomas showed a lipid peak in the solid portion of the tumor while the remaining tumors showed lipids in the necrotic areas. Conclusion: The combination of conventional and functional MRI techniques with intravenous contrast improve the diagnostic accuracy of CNS lymphoma.

  8. Burkitt-like lymphoma in an infant: a case report Linfoma burkitt-like em um lactente: relato de caso

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    Claudete Esteves Klumb

    2003-01-01

    Full Text Available Childhood non-Hodgkin's lymphomas, including Burkitt and Burkitt-like, are rarely diagnosed in infants. A case of B-cell lymphoma in a 13-month-old girl with extensive abdominal disease, ascites, pleural effusion, and tumor lysis syndrome is reported. Phenotypic analysis showed a germinal center B-cell phenotype, and a B-cell clonality was confirmed by polymerase chain reaction. There was no evidence of Epstein-Barr and HIV infection. The case herein reported emphasizes the need for considering the diagnosis of lymphoma even in very young children.Os linfomas não Hodgkin da infância, incluindo os linfomas de Burkitt e Burkitt-like são raros em lactentes. Um caso de linfoma não Hodgkin B em uma lactente de 13 meses de idade é descrito. Ao diagnóstico a paciente apresentava extenso comprometimento abdominal associado à ascite, derrame pleural e síndrome de lise tumoral. A análise imunofenotípica mostrou um fenótipo compatível com células linfóides oriundas do centro germinativo e a origem clonal dessas células foi demonstrada por reação em cadeia da polimerase. Não foi demonstrada associação do linfoma com infecção pelo vírus Epstein-Barr e/ou virus da imunodeficiência adquirida. O caso apresentado enfatiza a necessidade de considerar o diagnóstico de linfoma mesmo em lactentes.

  9. Linfoma T intestinal monomórfico CD56+. Primer caso informado en Colombia y revisión de la literatura

    Directory of Open Access Journals (Sweden)

    Diana Lucía Martínez-Baquero

    2015-01-01

    Full Text Available Se informa el caso de una mujer de 80 años con hallazgo incidental de masa abdominal en mesogastrio. Se le realiza resección de intestino delgado por sospecha de absceso con síndrome adherencial. El estudio patológico de la pieza quirúrgica demostró compromiso por linfoma no Hodgkin T monomórfico CD56+. Los linfomas T del tubo digestivo son inusuales; corresponden al 5% de las neoplasias linfoides de esta localización. El linfoma intestinal T monomórfico CD56+ corresponde a 10-20% de los linfomas T intestinales. Se presenta en regiones donde la enfermedad celiaca es infrecuente y no se asocia a enteropatía. Su curso es agresivo y habitualmente se manifiesta como una emergencia quirúrgica por obstrucción o perforación intestinal.

  10. Hiperplasia endotelial papilar intravascular oral: uma entidade rara Intravascular papillary endothelial hyperplasia: a rare entity

    OpenAIRE

    João Augusto Vianna Goulart Filho; Karuza Maria Alves Pereira; Hébel Cavalcanti Galvão

    2006-01-01

    A hiperplasia endotelial papilar intravascular (HEPI) é uma lesão vascular reativa caracterizada pela proliferação endotelial excessiva localizada no interior de vasos sangüíneos comumente dilatados, associada a trombos em organização, ou secundária a outras lesões vasculares, como hemangiomas e granulomas piogênicos. A HEPI é um achado incomum na cavidade oral, onde os lábios são o principal sítio de acometimento, e surge clinicamente sob a forma de nódulos azulados de aspecto clínico semelh...

  11. O transplante de células-tronco hematopoéticas no tratamento dos linfomas não Hodgkin Hematopoietic stem cell transplantation for non-Hodgkin lymphomas

    OpenAIRE

    Renata Baldissera; Ricardo Bigni; Abrahão E. Haallack Neto; Daniela F. Dias; Robenilson A. Souza; Carlos S. Chiattone; Cármino A. Souza

    2010-01-01

    No final da década de 70, ocorreu o primeiro relato de sucesso com a utilização de quimioterapia de alta dose, seguida de transplante de células-tronco hematopoéticas autólogo (TCTH auto), em pacientes com linfoma não Hodgkin (LNH). Desde então, o TCTH autólogo vem se constituindo em um importante instrumento na estratégia de tratamento dos LNH. Inúmeros estudos, em vários subtipos de linfomas, têm consolidado o papel do TCTH autólogo, principalmente como resgate em recidivas de doença. O mel...

  12. Disseminated Intravascular Coagulation Syndromes in Obstetrics.

    Science.gov (United States)

    Cunningham, F Gary; Nelson, David B

    2015-11-01

    Disseminated intravascular coagulation (DIC) is a syndrome that can be initiated by a myriad of medical, surgical, and obstetric disorders. Also known as consumptive coagulopathy, DIC is a common contributor to maternal morbidity and mortality and is associated with up to 25% of maternal deaths. The etiopathogenesis of DIC is complex and currently thought to be initiated by tissue factor or thromboplastin, which is released from trophoblastic or fetal tissue, or maternal decidua or endothelium. Tissue factor activates the coagulation sequence to cause fibrin clotting and its dissolution by the fibrinolysin system. The result of this process can range from mild, clinically insignificant laboratory derangements to marked coagulopathy with bleeding at sites of minimal trauma. Although clinical recognition varies by disease severity, several organizations have attempted to standardize the diagnosis through development of scoring systems. Several important--albeit not necessarily common--obstetric disorders associated with DIC include placental abruption, amniotic fluid embolism, sepsis syndrome, and acute fatty liver of pregnancy. More common disorders include severe preeclampsia, hemolysis, elevated liver enzymes, and low platelet count syndrome, and massive obstetric hemorrhage. Importantly, many of these disorders either cause or are associated with substantive obstetric hemorrhage. Treatment of DIC is centered on two principles. The first is identification and treatment of the underlying disorder. Because many women with consumptive coagulopathy also have massive hemorrhage, the second tenet of treatment is that obstetric complications such as uterine atony or lacerations must be controlled simultaneously with prompt blood and component replacement for a salutary outcome. PMID:26444122

  13. Disseminated intravascular coagulation in solid tumors

    International Nuclear Information System (INIS)

    It is estimated that 20-25% of cases of disseminated intravascular coagulation (DIC) relate to an underlying neoplasia primarily hematologic. It is estimated that about 5% of patients with solid tumors have CID clinic, although the incidence of subclinical alterations is much higher. The CID is not limited to the activation of the coagulation cascade, which leads to bleeding micro thrombosis and consumption of coagulation factors. Solid tumors are frequently associated adenocarcinomas producers mucin (especially gastric), usually in the context of a disseminated disease. The mucin may act as a promoter of the cascade, but probably it is a multi-event. High levels of TNF to produced by the tumor mass and chemotherapy-induced cell lysis have Also linked. Although the bleeding is usually oriented diagnosis, the most frequent cause of death is thrombosis. There are no specific tests for diagnosis. Elevated levels of D-dimer and products oriented fibrinogen degradation diagnosis. No reduction fibrinogen and almost always, one thrombocytopenia consumption. Treatment is complex and there is no consensus on many points. To recover the lost factors for consumption, it is recommended to use fresh frozen plasma and / or washed red blood cells. the heparin anticoagulation low dose is indicated since the disease causal can not be controlled quickly, but should not be initiated if there thrombocytopenia 50.000.El under profuse bleeding can require the use of tranexamic acid or EACA. Acute DIC, the case of our patient, is rare and very serious

  14. Las reglas de origen en los tratados de libre comercio

    Directory of Open Access Journals (Sweden)

    Marlon Iván Maldonado Narváez

    2014-01-01

    Full Text Available La presente revisión de los aspectos del libre comercio y las reglas de origen tiene como propósito hacer una evaluación general de los tratados de libre comercio en el ámbito colombiano, algunas de sus consecuencias y los ele- mentos que los componen, especialmente el referente al tema de las Reglas de Origen. El estudio de las Reglas de Origen, como uno de los aspectos fundamentales de las negociaciones de cualquier tratado de libre comercio, es determinante para entender si con ellas se busca proteger algún sector de la industria, o si por el contrario se establecen de manera abierta para facilitar el libre intercambio. Mediante una breve evaluación del Tratado de Libre Comercio entre Colombia y Estados Unidos, la postura asumida durante las negociaciones y los intereses de ambos países previamente a la firma del acuerdo se hace una valoración de lo riguroso que pueden ser las Reglas de Origen en dicho acuerdo.

  15. Linfoma primario de células T del páncreas: presentación de un caso clínico

    Directory of Open Access Journals (Sweden)

    Carolina I. Galarreta

    2012-10-01

    Full Text Available El Linfoma Primario de Páncreas es una enfermedad rara, representando el 1 % de todos los linfomas de presentación extranodal y el 0,5% de todas las masas pancreáticas. Menos de 150 casos han sido reportados en la literatura en ingles, los cuales son generalmente linfomas de células tipo B. Los linfomas de celulas T, representan aproximadamente el 4% de los linfomas primarios de pancreas y la supervivencia a los 5 años es del 0%. Reportamos el caso de una mujer de 28 años de edad que se presento a la emergencia con una colangitis aguda severa y una historia insidiosa de baja de peso e icteria obstructiva. La tomografía revelo una lesión tumoral heterogénea, difusa en cabeza de páncreas asi como dilatación leve del conducto pancreático, dilatación de vía biliar intra y extra-hepatica, no adenopatías retroperitoneales y sin infiltración hepática ni esplénica. Se realizo una autopsia dirigida y los estudios histopatologicos confirmaron un linfoma no Hodgkin de células T, CD3 + CD20-.

  16. Los tratados de libre comercio: instrumentos para controlar la biodiversidad

    OpenAIRE

    Rodríguez Cervantes, Silvia

    2013-01-01

    La soberanía de cada Estado para regular la Bioprospección y utilización de la biodiversidad contenida en sus fronteras, fue un derecho reforzado por el Convenio de Diversidad Biológica de 1994 y diez años más tarde por el Tratado conocido como Tratado de la Semilla. Sin embargo, sus alcances se han visto obstaculizados por diversos pactos comerciales y sus respectivas políticas de propiedad intelectual. Algunos son de carácter multilateral; otros son re...

  17. TRATADOS INTERNACIONALES DE DERECHOS HUMANOS BAJO EL ORDENAMIENTO JURÍDICO ALEMÁN

    Directory of Open Access Journals (Sweden)

    Roland Bank

    2003-01-01

    Full Text Available En el presente artículo el autor analiza la posición de los tratados internacionales en general, como asimismo, los tratados de derechos humanos y de integración en el sistema jurídico alemán, considerando la posición de la doctrina y la jurisprudencia emanada de la Corte Constitucional Alemana.The article analyzes the status in the German legal system of international treaties in general, and treaties on human rights and integration in particular, from the point of view of legal scholarship and the decisions of the German Constitutional Court.

  18. Linfoma primario de bazo. Presentación de un caso / Primary lymphoma of the spleen. Case presentation

    Scientific Electronic Library Online (English)

    Vicente Joaquín, Más Medina; Mirelquis, Rodríguez Rodríguez; Ania Inés, Cuellar Armas; Ariana Ofelia, Gómez Mutis; Ramsés Manuel, Más Herrera.

    2013-12-01

    Full Text Available Fundamento: en el bazo se pueden observar diferentes tipos de tumores, dentro de los cuales están los linfomas primarios del mismo, enfermedad infrecuente, de ahí la importancia de su presentación. Presentación de caso: paciente femenina de 66 años, raza blanca, con antecedentes de hipertensión arte [...] rial, lobectomía derecha del tiroides, que refiere venía presentando desde hacía más de un año dolor abdominal alto izquierdo que se hacía más intenso tras el esfuerzo físico, tos, presentando toma del estado general por lo que se ingresa en el servicio de cirugía. Se toman muestras para biopsia, después de ser intervenido quirúrgicamente de una esplenectomía, dando como resultado un Linfoma no Hodgkin de células grandes CD20 positivo, sin infiltración hepática, ganglionar ni epiplóica. Se realizó esplenectomía y quimioterapia. La paciente ha evolucionado favorablemente. Conclusiones: el linfoma primario de bazo es una entidad infrecuente y su diagnóstico es aún más raro en pacientes por encima de los 60 años, como ocurrió en el caso presentado. A medida que casos como este se divulguen entre los profesionales de la salud permitirán una aproximación diagnóstica más precisa a esta enfermedad poco común. Abstract in english Background: in the spleen you can see different types of tumors; primary lymphomas are an example of them. This is an infrequent disease, hence the importance of its presentation. Case presentation: 66 year old white female patient with history of hypertension, thyroid right lobectomy that refers to [...] have been suffering from high left abdominal pain for a year that became more intense after physical exertion, cough, presenting general malaise by what is admitted to the surgical service. Some samples for biopsy are taken, after being surgically operated of a splenectomy, showing as a result a non-Hodkin lymphoma of big cells resulting cell non-Hodgkin lymphoma CD20 Positive, without hepatic, ganglionic or epiploic infiltration. Splenectomy and chemotherapy were made. The patient has improved favorably. Conclusions: primary lymphoma of the spleen is a rare entity and its diagnosis is still rarer in patients over 60 years, as it happened in the case presented. As cases like these are disseminated among health professionals will allow a more accurate diagnostic approach to this rare disease.

  19. Intravascular brachytherapy for peripheral vascular disease

    Directory of Open Access Journals (Sweden)

    Hagen, Anja

    2008-09-01

    Full Text Available Scientific background: Percutaneous transluminal angioplasties (PTA through balloon dilatation with or without stenting, i.e. vessel expansion through balloons with or without of implantation of small tubes, called stents, are used in the treatment of peripheral artery occlusive disease (PAOD. The intravascular vessel irradiation, called intravascular brachytherapy, promises a reduction in the rate of repeated stenosis (rate of restenosis after PTA. Research questions: The evaluation addresses questions on medical efficacy, cost-effectiveness as well as ethic, social and legal implications in the use of brachytherapy in PAOD patients. Methods: A systematic literature search was conducted in August 2007 in the most important medical electronic databases for publications beginning from 2002. The medical evaluation included randomized controlled trials (RCT. The information synthesis was performed using meta-analysis. Health economic modeling was performed with clinical assumptions derived from the meta-analysis and economical assumptions derived from the German Diagnosis Related Groups (G-DRG-2007. Results: Medical evaluation: Twelve publications about seven RCT on brachytherapy vs. no brachytherapy were included in the medical evaluation. Two RCT showed a significant reduction in the rate of restenosis at six and/or twelve months for brachytherapy vs. no brachytherapy after successful balloon dilatation, the relative risk in the meta-analysis was 0.62 (95% CI: 0.46 to 0.84. At five years, time to recurrence of restenosis was significantly delayed after brachytherapy. One RCT showed a significant reduction in the rate of restenosis at six months for brachytherapy vs. no brachytherapy after PTA with optional stenting, the relative risk in the meta-analysis was 0.76 (95% CI: 0.61 to 0.95. One RCT observed a significantly higher rate of late thrombotic occlusions after brachytherapy in the subgroup of stented patients. A single RCT for brachytherapy vs. no brachytherapy after stenting did not show significant results for the rate of restenosis at six months. Both, early and late thrombotic occlusions appeared more frequently in the brachytherapy group. Health economic evaluation: Additional costs of brachytherapy were estimated to be 1,655 or 1,767 Euro according to the used G-DRG. The incremental cost-effectiveness ratio per avoided restenosis was calculated to be 8,484 Euro or 9,058 Euro for brachytherapy use after successful balloon dilatation, 19,027 Euro or 20,314 Euro for brachytherapy after PTA with optional stenting and -39,646 Euro or -48,330 Euro for brachytherapy after stenting. Discussion: Partially poor performing and reporting quality of the RCT exacerbate the interpretation and the transferability of the study results. The used methodical approach enables the highest evidence level for the determined results and presents a good approximation of the current brachytherapy related costs for the German health care system. Conclusions: Brachytherapy after successful balloon dilatation in PAOD can be recommended from a medical point of view for the reduction of the rate of restenosis at one year. However from a health economic view the answer is not yet clear. Based on the current data the use of brachytherapy after stenting in PAOD cannot be recommended neither from a medical nor from a health economic point of view. The informed consent of the patients is an important ethical aspect in the use of brachytherapy.

  20. La crítica de Hicks al Tratado del Dinero de Keynes

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    Alexander Tobón

    2004-12-01

    Full Text Available El objetivo de este artículo es mostrar que la crítica que hace Hicks al Tratado del Dinero de Keynes es incorrecta. Para ello, presentamos el modelo de Keynes, mostrando que la igualdad entre la inversión y el ahorro es una condición de equilibrio monetario y no una identidad. Este resultado no puede ser obtenido en el análisis de Hicks.

  1. Intravascular Ultrasound and its Use in Vascular Interventional Radiology

    International Nuclear Information System (INIS)

    Intravascular ultrasound has become in invasive vascular radiology in the last decade the important part of diagnostic and also therapeutic procedures in management of vascular diseases. The basic possibilities for the use of IVUS include diagnostic procedures in vascular pathology assessment and therapeutic indications in the field of peripheral vascular interventions (PVI). Unlike other image modalities (CT, MRI, ultrasound) IVUS enables gather unique image in real timeright from the vessel lumen, what helps to add important information regarding vessel wall, plate morphology, thrombi and cross-sectional vessel area. After initial use of intravascular ultrasound in coronary circulation, using IVUS is nowadays widely extended especially in aortic diseases, carotid and renal arteries and arteries of the lower extremities. This review article summarizes possibilities of intravascular ultrasound utilization in diagnostic process and therapy from peripheral vascular diseases up to thoracoabdominal aorta diseases and our experience with this new diagnostic modality. (author)

  2. Management of cancer-associated disseminated intravascular coagulation.

    Science.gov (United States)

    Levi, Marcel

    2016-04-01

    Cancer may be complicated by the occurrence of disseminated intravascular coagulation (DIC). DIC is characterized by a widespread and intravascular activation of coagulation (leading to intravascular fibrin deposition) and simultaneous consumption of coagulation factors and platelets (potentially resulting in bleeding). Clinically, DIC in cancer has in general a less fulminant presentation than the types of DIC complicating sepsis and trauma. A more gradual, but also more chronic, systemic activation of coagulation can proceed subclinically. Eventually this process may lead to exhaustion of platelets and coagulation factors and bleeding (for example at the site of the tumor) may be the first clinical symptom indicating the presence of DIC. In some cases, the clinical presentation of DIC in cancer may be reminiscent of thrombotic microangiopathies, which is understandable in view of the role of endothelium in both conditions. The therapeutic cornerstone of DIC is treatment of the underlying disorder but supportive treatment, specifically aimed at the hemostatic system may be required. PMID:27067981

  3. Emergency treatment by intravascular embolization in traumatic carotid cavernous fistula

    International Nuclear Information System (INIS)

    Objective: To discuss the method of intervenfional intravascular treatment in traumatic carotid cavernous fistula (TCCF) and the significance of clinical application in emergency. Methods: In 297 eases of TCCF, 36 cases were treated by interventional intravascular embolization by detachable balloon, embolization orificium or occlusion in one side of carotid artery. In the 36 cases, serious epistaxis occurred in 22 eases, cortical vein inflow in 9 cases, intracranial hemorrhage in 3 cases, aggravation of eyesight in 3 cases, and limb dysfunction in 2 cases. Results: Fistula was successfully embolized and internal carotid artery remained patent in 19 cases. Complete embolization of orificium or internal carotid artery was achieved in 17 eases. The serious epistaxias in 22 cases and intracranial hemorrhage in 3 cases stopped. Eyesight recovered in 2 eases and improved in 1 case. Limb dysfunction improved evidently in 2 cases. Conclusion: Intravascular embolization treatment is the first therapeutic choice for TCCF, especially in emergency. It is necessary, safe and effective. (authors)

  4. Linfoma primario de páncreas en un paciente de 27 anos de edad. Reporte de un caso

    OpenAIRE

    Andrea Fargier Paoli; Estrella Celeste Uzcátegui Paz; Fabiana Noboa; Jose L. Plata Patiño

    2013-01-01

    Los linfomas representan una pequeña fracción de todas las neoplasias malignas de páncreas, siendo inferior al 1 o 2%, y es aún más extremadamente extraño en individuos menores de 35 años, por lo que presentamos caso de linfoma primario de páncreas en un paciente de 27 años de edad, que presentó ictericia y dolor abdominal, como única sintomatología. El ultrasonido abdominal solo reportó litiasis biliar mixta, por lo que se programó cirugía electiva para colecistectomía y exploración biliar. ...

  5. Incidental Intravascular Lipoleiomyomatosis in A Hysterectomy Specimen: How To Manage?

    Science.gov (United States)

    Aslanova, Rakhshanda; Can, Nuray; Okten, Sabri Berkem; Aslan, Mehmet Musa

    2015-01-01

    Leiomyomas are common benign tumors in female gynaecologic surgery. They are originated from smooth muscle cells of the uterus and/or sometimes of the uterine vessels. Intravascular lipoleiomyomatosis is a very rare form of leiomyomas which grow within veins and can extend up to vena cava inferior and right heart chamber with cardiac symptoms and is diagnosed by cardiovascular surgeons. We report a case of incidental intravascular lipoleiomyomatosis which was confined to the uterus being diagnosed after a total abdominal hysterectomy by pathology and its management strategy. PMID:25738043

  6. 21 CFR 880.5970 - Percutaneous, implanted, long-term intravascular catheter.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Percutaneous, implanted, long-term intravascular... and Personal Use Therapeutic Devices § 880.5970 Percutaneous, implanted, long-term intravascular catheter. (a) Identification. A percutaneous, implanted, long-term intravascular catheter is a device...

  7. 76 FR 77834 - Scientific Information Request on Intravascular Diagnostic and Imaging Medical Devices

    Science.gov (United States)

    2011-12-14

    ...The Agency for Healthcare Research and Quality (AHRQ) is seeking scientific information submissions from manufacturers of intravascular diagnostic and imaging medical devices, including: Fractional Flow Reserve (FFR), Coronary Flow Reserve (CFR), Intravascular Ultrasound (IVUS), Intravascular Ultrasound (VH-IVUS) with Virtual Histology, Optical Coherent Tomography (OCT), Near- Infrared......

  8. Recurrence of peripheral T-cell lymphoma as granulomas in the lower limbs / Granulomas epitelióides cutâneos, como manifestação de recidiva de linfoma de células T periférico

    Scientific Electronic Library Online (English)

    Ana Rita, Travassos; João, Borges-Costa; João, Raposo; Luís Soares, Almeida; Paulo, Filipe.

    2012-10-01

    Full Text Available A presença de granulomas cutâneos associados a linfomas é um fenômeno raro, mas bem conhecido. Um homem, 44 anos de idade, com diagnóstico prévio de linfoma de células T periférico, foi enviado à nossa consulta por infiltração cutânea e extensa discromia nos membros inferiores. A biopsia cutânea rev [...] elou a presença de granulomas epitelioides associados à recidiva do linfoma, confirmada pela marcação imuno-histoquímica e estudo molecular. Apesar de iniciado novo esquema de quimioterapia, o doente faleceu 18 meses depois. Na literatura são descritos dois tipos de granulomas cutâneos na presença de linfomas: associados à infiltração cutânea pelo linfoma ou como uma manifestação não específica do linfoma. Contudo, atualmente não há evidência que suporte a sua relação com o prognóstico dos linfomas. Abstract in english The presence of granulomas in the skin of T-cell lymphoma patients is a rare but well-known phenomenon. The authors present the case of a 44-year-old Caucasian male, with a previously treated peripheral T-cell lymphoma, with cutaneous infiltration and extensive dyschromia on his lower limbs. Skin bi [...] opsies revealed the presence of sarcoid granulomas associated with the recurrence of the lymphoma, confirmed by immunostaining and molecular analysis. Although a new scheme of chemotherapy was started, he died 18 months later. There are two different patterns of skin granulomas associated with lymphoma: granulomatous infiltrates admixed with neoplastic cells and cutaneous granulomas constituting a nonspecific manifestation of the underlying lymphoma, but presently there is no evidence supporting their relationship with lymphoma prognosis.

  9. Apresentação cutânea inicial de linfomas na infância Initial cutaneous manifestation of lymphomas in children

    Directory of Open Access Journals (Sweden)

    Maria Christina Lopes Araujo de Oliveira

    2011-08-01

    Full Text Available Os linfomas cutâneos compreendem um grupo heterogêneo de desordens linfoproliferativas que envolvem a pele e são classificados como um subgrupo dos linfomas não Hodgkin. No período de 1981 a 2007, 100 casos de linfomas em crianças foram admitidos no Serviço de Hematologia, do Hospital das Clínicas da Universidade Federal de Minas Gerais, sendo que nove apresentaram manifestação cutânea inicial. Três pacientes foram classificados como linfoma cutâneo primário e seis como sistêmicos. Sete pacientes apresentaram linfoma de células T, um, linfoma linfoblástico B e um, imunofenótipo indefinido. Nenhum óbito ocorreu nos pacientes com linfoma cutâneo primárioCutaneous lymphomas comprise a heterogeneous group of lymphoproliferative disorders with skin involvement and are classified as a subgroup of non-Hodgkin lymphomas. From 1981 to 2007, 100 children with non-Hodgkin lymphomas were admitted to the Hematology Unit of the Federal University of Minas Gerais Teaching Hospital. In nine of these children, the skin was involved at the onset of the disease. Three patients were classified as having primary cutaneous lymphoma, while in six the disease was systemic with cutaneous involvement. In seven patients, the immunophenotype was T-cell, in one it was B-cell, and in the remaining case the immunophenotype was indefinable. No deaths occurred in any of the children with primary cutaneous lymphoma

  10. Leucemia / Linfoma T del Adulto Gástrico: Reporte de cuatro casos y Revisión de la Literatura

    Directory of Open Access Journals (Sweden)

    Brady Beltrán

    2010-04-01

    Full Text Available Leucemia / Linfoma T del Adulto (ATLL es una enfermedad agresiva asociada con el virus linfotrópico de células T tipo I (HTLV-1 con presentación y curso clínico heterogéneo. El reporte describe cuatro casos con compromiso gástrico, considerando características clínicas y hallazgos endoscópicos, con la respectiva revisión de la literatura.

  11. Linfoma ileal primário como uma causa de intussuscepção ileocecal recorrente Primary ileal lymphoma as a cause of recurrent ileocecal

    OpenAIRE

    Fábio César Miranda Torricelli; Roberto Iglesias Lopes; André Roncon Dias; Giovanni Scala Marchini; Wanderley Wesley Bonafé; Juliana Magalhães Lopes; Marcelo Rodrigues Borba

    2008-01-01

    INTRODUÇÃO: A intussuscepção ocorre quando um segmento proximal do intestino invagina para dentro do lúmen do segmento distal adjacente. Esta patologia é relativamente comum em crianças, sendo geralmente idiopática, diferentemente do que é evidenciado em adolescentes e adultos, os quais apresentam uma causa orgânica comprovada na maioria dos casos. O linfoma intestinal como etiologia desta patologia é extremamente raro. RELATO DE CASO: Um paciente de 16 anos, masculino, referindo dor abdomina...

  12. Burkitt's lymphoma of the duodenum in a patient with AIDS Linfoma de Burkitt do duodeno em um paciente com AIDS

    Directory of Open Access Journals (Sweden)

    Marcelo Corti

    2007-06-01

    Full Text Available Non-Hodgkin's lymphoma of B-cell type is the second most common neoplasm after Kaposi's sarcoma, among patients with human immunodeficiency virus infection. Most non-Hodgkin's lymphoma cases that are associated with acquired immunodeficiency syndrome involve extranodal sites, especially the digestive tract and the central nervous system. We report a case of primary lymphoma of the duodenum in a patient with AIDS. Upper gastrointestinal endoscopy revealed pseudopolypoid masses found in the second portion of the duodenum. A complete diagnostic study including histological, immunohistochemical and virological analyses showed high-grade B-cell Burkitt's lymphoma. The Epstein-Barr virus genome was detected in biopsies by immunohistochemical and in situ hybridization.O linfoma não-Hodgkin de células B é a segunda neoplasia mais comum em pacientes com infecção pelo vírus da imunodeficiência humana depois do sarcoma de Kaposi. A maioria dos casos de linfoma não-Hodgkin associados com a síndrome da imunodeficiência adquirida envolve locais extraganglionares, especialmente o trato digestivo e o sistema nervoso central. Nós relatamos um caso de linfoma primário do duodeno em um paciente com AIDS. Uma endoscopia digestiva alta mostrou massas pseudopolipóides encontradas na segunda porção do duodeno. Um estudo diagnóstico completo incluindo exames histológicos, imunohistoquímicos e virológicos mostrou um linfoma de células B tipo Burkitt. Detectou-se genoma do vírus Epstein-Barr em biópsias por hibridização in situ e imuno-histoquímica.

  13. Leucemia / Linfoma T del Adulto Gástrico: Reporte de cuatro casos y Revisión de la Literatura

    OpenAIRE

    Brady Beltrán; Eugenio Palomino; Pilar Quiñones; Domingo Morales; Esther Cotrina

    2010-01-01

    Leucemia / Linfoma T del Adulto (ATLL) es una enfermedad agresiva asociada con el virus linfotrópico de células T tipo I (HTLV-1) con presentación y curso clínico heterogéneo. El reporte describe cuatro casos con compromiso gástrico, considerando características clínicas y hallazgos endoscópicos, con la respectiva revisión de la literatura.

  14. Search of intravascular hemolysis in patients with the cutaneous form of loxoscelism Pesquisa de hemólise intravascular na forma cutânea de loxoscelismo

    OpenAIRE

    Pasquale Morena; Kimiyo Nonoyama; João Luiz C. CARDOSO; Orlando C. de O. Barreto

    1994-01-01

    Haptoglobin assay, a highly sensitive method to detect intravascular hemolysis was carried out in the sera of 19 patients referred to Hospital Vital Brazil with the cutaneous form of loxoscelism in order to investigate the occurrence of mild intravascular hemolysis. Data from this series did not show decreased levels haptoglobin, ruling out intravascular hemolysis in these patients with cutaneous form of loxoscelism.Dezenove pacientes que apresentaram a forma clínica cutânea do loxoscelismo f...

  15. Neonatal Compartment Syndrome Associated With Disseminated Intravascular Coagulation.

    Science.gov (United States)

    Badawy, Sherif M; Gust, Madeleine J; Liem, Robert I; Ball, Molly K; Gosain, Arun K; Sharathkumar, Anjali A

    2016-02-01

    Neonatal compartment syndrome is a rare, but devastating limb-threatening condition that requires early recognition and timely surgical intervention. We discuss the clinical presentation and management challenges of a neonate with forearm compartment syndrome and disseminated intravascular coagulation. PMID:25910025

  16. El Tratado de Lisboa (Un juego de espejos rotos

    Directory of Open Access Journals (Sweden)

    Juan Manuel de Faramiñán Gilbert

    2009-01-01

    Full Text Available El fracaso del Tratado por el que se establece una Constitución para Europa produjo un periodo de incertidumbre y perplejidad del que ha costado mucho sobreponerse. Por un momento, todo parecía resquebrajarse y se tuvo la sensación de que la imagen de unidad en la diversidad, que con tanta dificultad se había forjado, se partía hecha añicoscomo un espejo roto. No obstante, como en un “juego de espejos rotos”, el ideal europeísta se ha ido recomponiendo con un gran esfuerzo, dando lugar a un texto, el Tratado de Lisboa, que encierra una solución de compromiso con el fin de saldar la crisis cuando el futuro de la Unión Europea parecía oscurecerse. Como en los poemas de Alejandra Pizarnik, “cuando el palacio de la noche encierra su hermosura, pulsaremos los espejos hasta que nuestros rostros canten como ídolos” y, así fue como con un esfuerzo milimetrado se ha ido recomponiendo este rompecabezas de cristales con el fin de que en él se refleje, otra vez, la ansiada imagen global. Como se señala enPreámbulo del Tratado de Lisboa, deberemos estar resueltos a salvar una nueva etapa en proceso de integración europea y habrá que recordar “la importancia histórica de que la división del continente europeo haya tocado a su fin y la necesidad de sentar unas bases firmes para la construcción de la futura Europa”.

  17. Hiperplasia endotelial papilar intravascular oral: uma entidade rara Intravascular papillary endothelial hyperplasia: a rare entity

    Directory of Open Access Journals (Sweden)

    João Augusto Vianna Goulart Filho

    2006-02-01

    Full Text Available A hiperplasia endotelial papilar intravascular (HEPI é uma lesão vascular reativa caracterizada pela proliferação endotelial excessiva localizada no interior de vasos sangüíneos comumente dilatados, associada a trombos em organização, ou secundária a outras lesões vasculares, como hemangiomas e granulomas piogênicos. A HEPI é um achado incomum na cavidade oral, onde os lábios são o principal sítio de acometimento, e surge clinicamente sob a forma de nódulos azulados de aspecto clínico semelhante ao de lesões como hemangioma, mucocele e varicosidades. Sob o aspecto histopatológico, observam-se projeções papilares de tecido conjuntivo fibroso revestidas por uma ou duas camadas de células endoteliais no interior de um lúmen vascular. A principal peculiaridade da HEPI reside em sua semelhança histológica com o angiossarcoma e na possível interpretação errônea como neoplasia maligna. Neste artigo, os autores descrevem um caso de HEPI oral e realizam uma breve revisão da literatura, enfatizando suas características histopatológicas e o diagnóstico diferencial.Intravascular papillary endothelial hyperplasia (IPEH is a reactive vascular lesion characterized by excessive endothelial proliferation within a vascular lumen of commonly dilated vessels, associated to organizing thrombi or even secondary to other vascular lesions, such as hemagiomas and pyogenic granulomas. Oral lesions of IPEH are uncommon, being lips the most frequent site, followed by, in decreasing frequency, tongue and buccal mucosa. Clinically, IPEH appears as bluish nodules that resembles clinical features of lesions as hemangioma, mucocele and varice. On histopathological examination, IPEH presents as papillary projections composed by a fibrous core lined by one or two layers of plump endothelial cells, without evidence of celullar pleomorphism, mitotic activity or necrosis. The mean peculiarity of IPEH is its histologic similarity to angiosarcoma and possible misinterpretation with malignant neoplasm. In this article, the author describe a rare case of oral IPEH and review of literature, emphasizing its histopathologic features and diferencial diagnosis.

  18. Actividad laboral en una cohorte de pacientes con linfoma non Hodgkin

    Scientific Electronic Library Online (English)

    R., Molina Villaverde; J., Feliu Batle; A., Villalba Yllan; A.M., Jiménez Gordo; B., San José Valiente; M., González Barón.

    2008-03-01

    Full Text Available Introducción. La actividad laboral en el cáncer es un aspecto psicosocial que ha recibido poca atención hasta el momento actual, a pesar de considerarse una dimensión de la calidad de vida para estos pacientes. Objetivos. La reinserción y adaptación al entorno laboral fueron investigados en una coho [...] rte de pacientes con linfoma no Hodgkin para describir los factores que influyen en la vuelta al trabajo de estos enfermos. Pacientes y métodos. El estudio incluyó 37 pacientes consecutivos diagnosticados de un linfoma no Hodgkin y empleados en el momento del diagnóstico. El cuestionario incluyó aspectos epidemiológicos, clínicos y laborales (32 variables en total). El estudio fue aprobado por el Comité Ético y de Investigación Cínica del Hospital La Paz. Todos los pacientes dieron su consentimiento para participar en el estudio y para la utilización de los datos de su historia clínica. Resultados. El 86,5% de los pacientes pasaron a inactivos tras comenzar el tratamiento de la enfermedad y un 32,5% lo seguían estando tras éste. No hubo diferencias en la influencia de las distintas variables analizadas con respecto a la actividad laboral tras el diagnóstico. Sin embargo, el realizar un trabajo predominantemente físico y la presencia de secuelas derivadas del tumor o del tratamiento de éste, sí influyeron en la reinserción laboral una vez finalizado el tratamiento específico. La mayoría de los pacientes no creían que el tener la enfermedad les perjudicaría en su puesto de trabajo y, en casi todos los casos, tanto sus compañeros como sus jefes conocían que tenían un tumor. Conclusiones. Éste es el primer estudio exploratorio en nuestro país acerca de la reinserción laboral de los pacientes diagnosticados de un linfoma. Son necesarios más trabajos para establecer las dificultades que tienen este tipo de enfermos en la reinserción laboral y establecer las medidas adecuadas para la mejora de este proceso. Abstract in english Background. Cancer affects many dimensions determining quality of life, including work. However, the importance of work to cancer survivors has received little attention. Aim. Employment and work-related disability were investigated in a cohort of non-Hodgkin´s lymphoma patients to describe a possib [...] le discrimination and other work issues. Patients and Methods. The study included consecutively 37 non-Hodgkin´s lymphoma patients who were employed at diagnosis. The questionnaire included cancerrelated symptoms and work-related factors. Clinical details were obtained from the medical record. Patients were interviewed face to face and 32 variables were recorded. The study was approved by the Ethical Committee of Hospital La Paz. All patients gave consent to participate. Results. Eighty six per cent of patients were unable to work after diagnosis, but 68% returned to work at the end of treatment. The type of worker and the sequelae of the disease or its treatment were independently associated with the ability to work after the end of treatment. Almost all patients told their employers and co-workers about their disease. None reported job discrimination. Conclusions. This is the first exploratory study in Spain about labour reintegration in non-Hodgkin´s lymphomas. Further studies are necessary.

  19. Actividad laboral en una cohorte de pacientes con linfoma non Hodgkin

    Directory of Open Access Journals (Sweden)

    R. Molina Villaverde

    2008-03-01

    Full Text Available Introducción. La actividad laboral en el cáncer es un aspecto psicosocial que ha recibido poca atención hasta el momento actual, a pesar de considerarse una dimensión de la calidad de vida para estos pacientes. Objetivos. La reinserción y adaptación al entorno laboral fueron investigados en una cohorte de pacientes con linfoma no Hodgkin para describir los factores que influyen en la vuelta al trabajo de estos enfermos. Pacientes y métodos. El estudio incluyó 37 pacientes consecutivos diagnosticados de un linfoma no Hodgkin y empleados en el momento del diagnóstico. El cuestionario incluyó aspectos epidemiológicos, clínicos y laborales (32 variables en total. El estudio fue aprobado por el Comité Ético y de Investigación Cínica del Hospital La Paz. Todos los pacientes dieron su consentimiento para participar en el estudio y para la utilización de los datos de su historia clínica. Resultados. El 86,5% de los pacientes pasaron a inactivos tras comenzar el tratamiento de la enfermedad y un 32,5% lo seguían estando tras éste. No hubo diferencias en la influencia de las distintas variables analizadas con respecto a la actividad laboral tras el diagnóstico. Sin embargo, el realizar un trabajo predominantemente físico y la presencia de secuelas derivadas del tumor o del tratamiento de éste, sí influyeron en la reinserción laboral una vez finalizado el tratamiento específico. La mayoría de los pacientes no creían que el tener la enfermedad les perjudicaría en su puesto de trabajo y, en casi todos los casos, tanto sus compañeros como sus jefes conocían que tenían un tumor. Conclusiones. Éste es el primer estudio exploratorio en nuestro país acerca de la reinserción laboral de los pacientes diagnosticados de un linfoma. Son necesarios más trabajos para establecer las dificultades que tienen este tipo de enfermos en la reinserción laboral y establecer las medidas adecuadas para la mejora de este proceso.Background. Cancer affects many dimensions determining quality of life, including work. However, the importance of work to cancer survivors has received little attention. Aim. Employment and work-related disability were investigated in a cohort of non-Hodgkin´s lymphoma patients to describe a possible discrimination and other work issues. Patients and Methods. The study included consecutively 37 non-Hodgkin´s lymphoma patients who were employed at diagnosis. The questionnaire included cancerrelated symptoms and work-related factors. Clinical details were obtained from the medical record. Patients were interviewed face to face and 32 variables were recorded. The study was approved by the Ethical Committee of Hospital La Paz. All patients gave consent to participate. Results. Eighty six per cent of patients were unable to work after diagnosis, but 68% returned to work at the end of treatment. The type of worker and the sequelae of the disease or its treatment were independently associated with the ability to work after the end of treatment. Almost all patients told their employers and co-workers about their disease. None reported job discrimination. Conclusions. This is the first exploratory study in Spain about labour reintegration in non-Hodgkin´s lymphomas. Further studies are necessary.

  20. Enfermedad Celiaca y Obstrucción Intestinal por Linfoma de Células T

    Directory of Open Access Journals (Sweden)

    Augusto Vera

    2011-07-01

    Full Text Available Paciente varón de 55 años, raza blanca (ascendencia española, natural y procedente de Ayacucho, que ingresó por una enfermedad de seis meses de evolución, caracterizada por dolor abdominal tipo cólico y baja ponderal de 10 Kg. Había estado hospitalizado seis meses antes y dado de alta con el diagnóstico de síndrome de intestino irritable. Entre sus antecedentes refería intolerancia a la lactosa y artritis reumatoidea. Los exámenes mostraron: Hb:12 g/dl, leucocitos: 5260 cel/mm, abastonados: 11%, albúmina: 2,7 mg/ml y VSG: 33mm/h. El resto de exámenes -incluyendo los marcadores tumorales- fueron normales. El tránsito gastrointestinal mostraba las asas delgadas con fragmentación del bario y dilatación focal moderada de un asa yeyunal distal. La tomografía de tórax, abdomen y pelvis sin alteraciones; Rx tórax normal. La colonoscopia fue normal; el íleon tenía pocos pliegues y pequeñas nodulaciones, las biopsias indicaron "ileitis inespecífica". La endoscopia mostró gastritis y una cicatriz de úlcera duodenal; la mucosa duodenal mostraba áreas con aspecto de mosaico rosado-blanquecino. La biopsia duodenal evidenció acortamiento de vellosidades, infiltrado inflamatorio crónico e incremento de linfocitos intraepiteliales, hallazgos compatibles con los criterios de celiaquía Marsh-tipo 3. Los anticuerpos IgA antiendomisio y antitransglutaminasa tisular estaban incrementados. Durante su hospitalización aumentó el dolor y aparecieron signos de obstrucción. En la laparotomía se encontraron una tumoración yeyunal estenosante y una perforación adyacente. El espécimen mostró un linfoma intestinal de células T. Se ha demostrado que existen más celiacos subclínicos que celiacos con esprue clásico; el conocimiento de esta situación nos debe llevar a tenerla presente por sus complicaciones o asociaciones, una de las cuales es el linfoma primario intestinal.

  1. Linfomas no Hodgkin: Área metropolitana de Bucaramanga Non-Hodgkin lymphomas from Bucaramanga metropolitan area

    Directory of Open Access Journals (Sweden)

    Carlos Alberto García Ramírez

    2011-04-01

    Full Text Available Introducción: Ninguna neoplasia ha generado tanta confusión en sus sistemas de clasificación como los linfomas no Hodgkin (LNH. Una correcta tipificación es necesaria para el diagnóstico, pronóstico y tratamiento. Objetivos: clasificar los LNH del registro poblacional de cáncer del área metropolitana de Bucaramanga. Pacientes y métodos: SSe realizó un estudio observacional de corte transversal, utilizando como población los pacientes con LNH del área metropolitana de Bucaramanga de enero de 2000 a diciembre de 2006. La información se obtuvo de las historias clínicas y de inmunohistoquímica en bloques de parafina. Se utilizo la clasificación de linfomas de la OMS. Resultados: Se estudiaron 320 pacientes y se encontró predominio de la enfermedad en la 6ª y 7ª década. La distribución por género fue mayor en hombres con 61,26% y mujeres 45,6%. El sitio anatómico de compromiso más frecuente fue ganglios cervicales con 25,6%. La mayoría expresaron antígenos B, 86,8%, y T, 1,8%. El subtipo más frecuente fue difuso de célula grande en el 29,6%. Conclusiones: La mayoría los LNH del área metropolitana de Bucaramanga son de linajes B, nodales y de célula grande difuso. Fue evidente el uso limitado de otras técnicas para la clasificación de estas neoplasias en nuestra región. Salud UIS 2011; 43(1: 39-47Introduction: There is not a neoplasm that has generated such confusion on its classification system such as the Non- Hodgkin's lymphoma. An adequate classification is necessary for diagnosis, prognostic and treatment. Objectives: To classify the NHL from the Bucaramanga metropolitan area poblational cancer registry. Patients and methods: An observational cross-sectional study was made, using as population the patients with NHL from the Bucaramanga metropolitan area from January 2000 until December 2006. The information was obtained from the clinical records and inmunohistochemistry in paraffin blocks. The WHO lymphoma classification was used. Results: 320 patients were studied and a predominance of the disease was found on the 6th and 7th decade of life. Gender distribution was higher in men with 61.26% and women 45.6%. The anatomical site more frequently affected were the cervical lymph nodes with 25.6%. Most of them expressed B antigens, 86.8%, and T, 1.8%. The most frequent subtype was diffuse large B cell in 29.6%. Conclusions: Most of the NHL from the Bucaramanga metropolitan area are nodal, of B lineage, and diffuse large cell subtype. The limited use of other techniques for the classification of these neoplasms in our region was evident. Salud UIS 2011; 43(1: 39-47.

  2. Linfomas plasmoblásticos del tracto gastrointestinal en pacientes con sida

    Directory of Open Access Journals (Sweden)

    Alejandro Avilés-Salas

    2011-12-01

    Full Text Available Los pacientes con infección por el virus de inmunodeficiencia humana (HIV tienen 200 veces más riesgo de desarrollar un linfoma no Hodgkin (LNH con respecto a la población general. El linfoma plasmoblástico (LP representa menos del 3% de todos los LNH asociados con el HIV. El objetivo de este estudio es informar las características clínico-patológicas de 5 pacientes con enfermedad HIV/sida y LP del tracto gastrointestinal. Se revisaron de forma retrospectiva los casos de LP del tracto gastrointestinal diagnosticados en el Instituto Nacional de Cancerología de la Ciudad de México en el periodo comprendido entre los años 2000 al 2009. Se analizaron las características clínico-patológicas y se realizaron cortes de bloques de tejidos embebidos en parafina para reacciones de inmunohistoquímica. La presencia del virus de Epstein Barr (VEB se examinó por reacción en cadena de la polimerasa (PCR in situ. De los cinco pacientes, cuatro fueron hombres y una mujer, con una mediana de edad de 29 años. Tres tumores se localizaron en la región anorrectal, uno en colon ascendente y el restante en el estómago. Histológicamente, todos los tumores se caracterizaron por una proliferación difusa de células grandes de aspecto plasmoblástico. Las células neoplásicas fueron CD 138/MUM-1 positivas y CD 20 / PAX-5 negativas. En cuatro pacientes se detectó el genoma del VEB en las células neoplásicas mediante PCR in situ. La mediana de seguimiento fue 18 meses; tres pacientes estaban vivos con enfermedad y dos sobreviven sin evidencias de la neoplasia. El diagnóstico precoz de LP como una entidad clínico-patológica es importante para establecer el tratamiento correcto y mejorar el pronóstico de estos pacientes.

  3. Linfoma plasmablástico: un caso con enfermedad rectal y compromiso de médula ósea en un paciente VIH positivo

    Directory of Open Access Journals (Sweden)

    Grisley García Chihuan

    2014-10-01

    Full Text Available El linfoma plasmablástico es una variante agresiva del linfoma difuso de células grandes B, descrito inicialmente en pacientes VIH positivos asociados a lesiones en cavidad oral. Este corresponde al 2% de LNH asociado a VIH. Esta entidad actualmente representa un reto para el diagnóstico y el tratamiento, presentando o un pobre pronóstico o. El presente reporte describe un paciente con HIV en tratamiento con TARGA, un recuento CD4 en 490 células/ml, asociado a un Linfoma plasmablástico con compromiso rectal y médula ósea. El paciente recibe el régimen EPOCH por 6 ciclos con respuesta completa.

  4. Linfoma folicular primario intestinal no polipósico: reporte de un caso y revisión de la literatura

    Directory of Open Access Journals (Sweden)

    Brady Beltran

    2015-01-01

    Full Text Available El linfoma folicular primario intestinal es un desorden raro descrito en la última clasificación de linfomas de la WHO. Es una entidad localizada con excelente pronóstico. En el presente artículo, reportamos una mujer peruana de 64 años de edad diagnosticada con linfoma folicular primario intestinal. Ella tuvo dos años con dolor abdominal y vómitos tardíos. Ella desarrolló una obstrucción intestinal y tuvo una resección completa del tumor. Se describe el caso y se realiza una revisión de la literatura de esta entidad

  5. Neuroimagen del linfoma primario del sistema nervioso central en pacientes inmunodeprimidos

    Scientific Electronic Library Online (English)

    C, Sobrido Sampedro; J.D, Corroto; M, Arias González; A, Iglesias Castañón; J, Corroto Murua; J.M, Pumar Cebreiro.

    2014-04-01

    Full Text Available Objetivos: El linfoma primario del sistema nervioso central (LPSNC) es una entidad rara con un pronóstico fatal. Dado el aumento en el número de casos con inmunosupresión adquirida, nuestros objetivos son estudiar las características epidemiológicas y neurorradiológicas de aquellos pacientes inmunod [...] eprimidos con diagnóstico de LPSNC con afectación cerebral e investigar si existen diferencias entre los pacientes con el virus de la inmunodefi ciencia humana (VIH) positivo y negativo. Materiales y métodos: Se realizó un estudio descriptivo y retrospectivo de los pacientes inmunodeprimidos con afectación cerebral por LPSNC, diagnosticados durante los últimos 13 años en 2 hospitales de referencia. Se evaluaron múltiples variables. El nivel de significación estadística utilizado fue p Abstract in english Purposes: Primary central nervous system lymphoma (PCNSL) is a rare tumour with poor prognosis. Due to the increased number of patients with acquired immunodeficiency, our purposes are to describe epidemiological and imaging findings in immunodeficient patients with PCNSL of the brain and to study t [...] he differences between HIV-positive and HIV-negative patients with PCNSL. Materials and methods: A retrospective, descriptive study was performed with immunodeficient patients diagnosed of PCNSL of the brain during the last 13 years in two reference hospitals. Twenty-one patients fulfilled the inclusion criteria. Multiple variables were evaluated. Significance was defined as p

  6. Acuerdo intraobservador en estudios de inmunohistoquímica para Linfoma B difuso de célula grande según protocolo de Hans

    OpenAIRE

    Castellanos Olarte, Willian Almir

    2012-01-01

    OBJETIVO: Determinar el grado de acuerdo intraobservador para el diagnóstico del origen celular de muestras de pacientes con Linfoma B difuso de célula grande siguiendo el protocolo de Hans. DISEÑO: Corresponde a un estudio de correlación intraobservador. POBLACIÓN: Muestras de pacientes del Servicio de Patología del Instituto Nacional de Cancerologí­a con diagnóstico de Linfoma B difuso de célula grande. METODOLOGIA: Se calculó un tamaño de muestra de 62 pacientes para obtener un ...

  7. Linfomas B y T: Diagnóstico inmunofenotípico de los linfomas no hodgkinianos B-and T-lymphomas. Immunophenotypical diagnosis of non-Hodgkin lymphomas

    Directory of Open Access Journals (Sweden)

    Bertha B Socarrás Ferrer

    2003-04-01

    Full Text Available Los linfomas no hodgkinianos son neoplasias linfoides que pueden presentar fenotipo de células B ó T; las de tipo B son más frecuentes, mientras que los linfomas de tipo T tienen peor pronóstico y por lo general son más agresivos. En el ámbito internacional, la sobrevida de estas enfermedades es de aproximadamente 5 años, y en nuestro país se encuentran entre las 10 primeras causas de cáncer en ambos sexos, con prevalencia ligeramente mayor en el sexo masculino (1,3:1. Se destaca además, entre algunos aspectos, la importancia del estudio inmunofenotípico para determinar la naturaleza de estos procesos neoplásicos y distinguir entre enfermedad de Hodgkin, linfomas no hodgkinianos e infiltraciones por otros procesos linfoides, también para poder establecer factores pronósticos y de progresión en estos desórdenes linfoproliferativosThe non-Hodgkin lymphomas are lymphoid neoplasias that may present phenotype of cells B or T. The B-lymphomas are more frequent, whereas the T-lymphomas have a worse prognosis and they are generally aggressive. The survival of these diseases is of approximately 5 years at the international level. In our country, it is among the first 10 causes of death in both sexes, with a slightly higher prevalence in males (1.3:1. It is also stressed, among some other aspects, the importance of the immunophenotypical study to determine the nature of these neoplastic processes and to distinguish between Hodgkin disease, non-Hodgkin lymphomas and infiltrations due to other lymphoid processes, and to establish prognostic and progression factors in these lymphoproliferative disorders

  8. Theoretical model of intravascular paramagnetic tracers effect on tissue relaxation

    DEFF Research Database (Denmark)

    Kjølby, Birgitte Fuglsang; Østergaard, Leif; Kiselev, Valerij G

    2006-01-01

    The concentration of MRI tracers cannot be measured directly by MRI and is commonly evaluated indirectly using their relaxation effect. This study develops a comprehensive theoretical model to describe the transverse relaxation in perfused tissue caused by intravascular tracers. The model takes...... indicate that the relaxivity of intravascular contrast agents depends significantly on the host tissue. This agrees with experimental data by Johnson et al. (Magn Reson Med 2000;44:909). In particular, the present results suggest a several-fold increase in the relaxivity of Gd-based contrast agents in...... brain tissue compared with bulk blood. The enhancement of relaxation in tissue is due to the contrast in magnetic susceptibility between blood vessels and parenchyma induced by the presence of paramagnetic tracer. Beyond the perfusion measurements, the results can be applied to quantitation of...

  9. Silent Intravascular Lymphoma Initially Manifesting as a Unilateral Adrenal Incidentaloma

    OpenAIRE

    Yoshiko Takahashi; Keiji Iida; Yasuhisa Hino; Takeshi Ohara; Toshifumi Kurahashi; Takashi Tashiro; Kazuo Chihara

    2012-01-01

    Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of malignant lymphoma. Although the involvement of adrenal glands in IVLBCL is often observed, primary adrenal IVLBCL is rare. Most reported cases of adrenal IVLBCL showed bilateral lesions resulting in rapidly progressive adrenal failure and poor prognosis. Here, we report a case of slowly progressive primary adrenal IVLBCL manifesting initially with unilateral adrenal incidentaloma. This case is a silent IVLBCL and shows that th...

  10. Design of low noise transimpedance amplifier for intravascular ultrasound

    KAUST Repository

    Reda, Dina

    2009-11-01

    In this paper, we study transimpedance amplifiers for capacitive sensing applications with a focus on Intravascular Ultra Sound (IVUS). We employ RF noise cancellation technique on capacitive feedback based transimpedance amplifiers. This technique eliminates the input-referred noise of TIAs completely and enhances the dynamic range of front-end electronics. Simulation results verify the proposed technique used in two different TIA topologies employing shunt-shunt feedback. ©2009 IEEE.

  11. Scanning electron microscopy of bacteria adherent to intravascular catheters.

    OpenAIRE

    Franson, T R; Sheth, N. K.; Rose, H D; Sohnle, P G

    1984-01-01

    Scanning electron microscopy was used to assess the morphological features of coagulase-negative staphylococci adherent to polyvinylchloride intravascular catheter specimens. Clinical specimens were obtained by using patient catheters from which coagulase-negative staphylococci (greater than or equal to 15 colonies per catheter) grew on semiquantitative blood agar roll cultures. In vitro specimens were prepared by a previously published technique in which sterile polyvinylchloride catheters w...

  12. Heartbeat OCT: in vivo intravascular megahertz-optical coherence tomography

    OpenAIRE

    Wang, Tianshi; Pfeiffer, Tom; Regar, Evelyn; Wieser, Wolfgang; Van Beusekom, Heleen; Lancee, Charles T.; Springeling, Geert; Krabbendam, Ilona; Van Der Steen, Antonius F.W.; Huber, Robert; Soest, Gijs

    2015-01-01

    Cardiac motion artifacts, non-uniform rotational distortion and undersampling affect the image quality and the diagnostic impact of intravascular optical coherence tomography (IV-OCT). In this study we demonstrate how these limitations of IV-OCT can be addressed by using an imaging system that we called “Heartbeat OCT”, combining a fast Fourier Domain Mode Locked laser, fast pullback, and a micromotor actuated catheter, designed to examine a coronary vessel in less than one cardiac cycle. We ...

  13. Central Venous Catheter Intravascular Malpositioning: Causes, Prevention, Diagnosis, and Correction.

    Science.gov (United States)

    Roldan, Carlos J; Paniagua, Linda

    2015-09-01

    Despite the level of skill of the operator and the use of ultrasound guidance, central venous catheter (CVC) placement can result in CVC malpositioning, an unintended placement of the catheter tip in an inadequate vessel. CVC malpositioning is not a complication of central line insertion; however, undiagnosed CVC malpositioning can be associated with significant morbidity and mortality. The objectives of this review were to describe factors associated with intravascular malpositioning of CVCs inserted via the neck and chest and to offer ways of preventing, identifying, and correcting such malpositioning. A literature search of PubMed, Cochrane Library, and MD Consult was performed in June 2014. By searching for "Central line malposition" and then for "Central venous catheters intravascular malposition," we found 178 articles written in English. Of those, we found that 39 were relevant to our objectives and included them in our review. According to those articles, intravascular CVC malpositioning is associated with the presence of congenital and acquired anatomical variants, catheter insertion in left thoracic venous system, inappropriate bevel orientation upon needle insertion, and patient's body habitus variants. Although plain chest radiography is the standard imaging modality for confirming catheter tip location, signs and symptoms of CVC malpositioning even in presence of normal or inconclusive conventional radiography findings should prompt the use of additional diagnostic methods to confirm or rule out CVC malpositioning. With very few exceptions, the recommendation in cases of intravascular CVC malpositioning is to remove and relocate the catheter. Knowing the mechanisms of CVC malpositioning and how to prevent, identify, and correct CVC malpositioning could decrease harm to patients with this condition. PMID:26587087

  14. Central Venous Catheter Intravascular Malpositioning: Causes, Prevention, Diagnosis, and Correction

    Directory of Open Access Journals (Sweden)

    Carlos J. Roldan

    2015-10-01

    Full Text Available Despite the level of skill of the operator and the use of ultrasound guidance, central venous catheter (CVC placement can result in CVC malpositioning, an unintended placement of the catheter tip in an inadequate vessel. CVC malpositioning is not a complication of central line insertion; however, undiagnosed CVC malpositioning can be associated with significant morbidity and mortality. The objectives of this review were to describe factors associated with intravascular malpositioning of CVCs inserted via the neck and chest and to offer ways of preventing, identifying, and correcting such malpositioning. A literature search of PubMed, Cochrane Library, and MD Consult was performed in June 2014. By searching for “Central line malposition” and then for “Central venous catheters intravascular malposition,” we found 178 articles written in English. Of those, we found that 39 were relevant to our objectives and included them in our review. According to those articles, intravascular CVC malpositioning is associated with the presence of congenital and acquired anatomical variants, catheter insertion in left thoracic venous system, inappropriate bevel orientation upon needle insertion, and patient’s body habitus variants. Although plain chest radiography is the standard imaging modality for confirming catheter tip location, signs and symptoms of CVC malpositioning even in presence of normal or inconclusive conventional radiography findings should prompt the use of additional diagnostic methods to confirm or rule out CVC malpositioning. With very few exceptions, the recommendation in cases of intravascular CVC malpositioning is to remove and relocate the catheter. Knowing the mechanisms of CVC malpositioning and how to prevent, identify, and correct CVC malpositioning could decrease harm to patients with this condition.

  15. Acute Intravascular Hemolysis and Methemoglobinemia Following Naphthalene Ball Poisoning

    OpenAIRE

    Kapoor, Rajan; Suresh, P.; Barki, Satish; Mishra, Mayank; M K Garg

    2014-01-01

    Naphthalene (C10H8) is a natural component of fossil fuels such as petroleum, diesel and coal. The common consumer products made from naphthalene are moth repellents, in the form of mothballs or crystals, and toilet deodorant blocks. Major toxic effects of naphthalene are due to precipitation of acute intravascular hemolysis. Very few cases of naphthalene poisoning and its effects have been reported from India. We report a case of accidental naphthalene poisoning, who presented with intravasc...

  16. Criptosporidiosis experimental en ratones albinos tratados con Metilprednisolona

    Directory of Open Access Journals (Sweden)

    María del P Hurtado

    2010-12-01

    Full Text Available Cryptosporidium spp., es un coccidio intracelular de distribución mundial responsable de un síndrome entérico en el hospedador inmunocompetente e inmunocomprometido. Se estudio la influencia inmunosupresora de la metilprednisolona (MP en la evolución de la criptoporidiosis experimental en ratones de laboratorio. Se utilizaron dos grupos de cuatro ratones machos jóvenes cada uno; el primer grupo incluyó cuatro ratones infectados y tratados en forma interdiaria con MP a dosis de 16 mg/kg de peso durante cuatro semanas y el segundo grupo (control cuatro ratones infectados y no tratados. El inóculo fue preparado a partir de Cryptosporidium spp. obtenido de un paciente con criptosporidiosis intestinal, administrando un volumen de 0,1 mL a través de una sonda oro-esofágica. Cada semana, se recogieron muestras de heces para realizar diagnóstico de criptosporidiosis intestinal mediante la coloración de Kinyoun. Se estudió la diseminación visceral del parásito tomando semanalmente un animal de cada grupo para necropsia, obteniéndose muestras de cada órgano para estudio histopatológico. Las formas parasitarias observadas, en tejidos, fueron como sigue: ooquistes, esporozoítos falciformes, formas sexuales, merozoítos libres y trofozoítos. Durante las cuatro semanas de estudio, la forma parasitaria predominante fue la de merozoíto libre. Se observó diseminación tisular en tráquea, glándula tiroides, intestino, bazo y ganglio linfático. No se observó el parásito en esófago, hígado, riñón y pulmón. En el grupo control la presencia del parásito se mantuvo limitada al intestino. La supervivencia de los animales fue del 100% en ambos grupos durante el período de estudio. La respuesta observada en los animales tratados con MP se expresó de manera evidente en la diseminación tisular del parásito en órganos distintos del aparato digestivo, efecto no demostrado en los animales infectados y no tratados. Sin embargo, el número total de formas parasitarias cuantificadas, no presentó diferencias notables durante las cuatro semanas que duró el experimento, pero si pudo demostrar que no es necesario un alto grado de inmunosupresión para que Criptosporidium spp. produzca formas extra-intestinales de la criptosporidiosis.

  17. Cutaneous collagenous vasculopathy associated with intravascular occlusive fibrin thrombi.

    Science.gov (United States)

    Salama, Samih; Chorneyko, Kathy; Belovic, Brian

    2014-04-01

    Cutaneous collagenous vasculopathy (CCV) is a rare cutaneous microangiopathy that clinically resembles generalized essential telangiectasia with only 12 cases reported to date. The perivascular fibrosis is thought to be due to production of abnormal collagen by veil cells in the outer vessel walls as a result of unknown factors. This report is of an 84-year-old male with progressive telangiectasia. Biopsies showed characteristic features of CCV. In addition, there were multiple intravascular fibrin thrombi, some organizing and associated with endothelial cell hyperplasia with recanalization reminiscent of glomeruloid bodies and simulating reactive angioendotheliomatosis (RAE). Histochemically and ultrastructurally fibrin was noted within the vessel walls integrating into the fibrous tissue around the vessels; however, the patient had no evidence of coagulation disorder, cryoglobulinemia or cold agglutinemia. Immunofluorescence showed fibrinogen within the vessel walls but no immunoglobulins or C3. As well, there were minimal inflammatory cells. This suggests pauci-inflammatory injury to the endothelial cells by unknown angiogenic factors causing local intravascular fibrin thrombi with fibrin leaking and incorporating into the vessel walls, eventually leading to reparative perivascular fibrosis. This case suggests that some cases of CCV are related to a primary local intravascular occlusive thrombotic microangiopathy. However, the primary triggering factor causing the endothelial cell damage has yet to be elucidated. PMID:24350781

  18. Vascular wall stress during intravascular optical coherence tomography imaging

    Science.gov (United States)

    Sun, Cuiru; Yang, Victor

    2015-03-01

    Biomechanical properties of arterial wall is crucial for understanding the changes in the cardiovascular system. Catheters are used during intravascular optical coherence tomography (IVOCT) imaging. The presence of a catheter alters the flow field, pressure distribution and frictional resistance to flow in an artery. In this paper, we first study the transmural stress distribution of the catheterized vessel. COMSOL (COMSOL 4.4) was used to simulate the blood flow induced deformation in a catheterized vessel. Blood is modeled as an incompressible Newtonian fluid. Stress distribution from an three-layer vascular model with an eccentric catheter are simulated, which provides a general idea about the distribution of the displacement and the stress. Optical coherence elastography techniques were then applied to porcine carotid artery samples to look at the deformation status of the vascular wall during saline or water injection. Preliminary simulation results show nonuniform stress distribution in the circumferential direction of the eccentrically catheterized vascular model. Three strain rate methods were tested for intravascular OCE application. The tissue Doppler method has the potential to be further developed to image the vascular wall biomechnical properties in vivo. Although results in this study are not validated quantitatively, the experiments and methods may be valuable for intravascular OCE studies, which may provide important information for cardiovascular disease prevention, diagnosis and treatment.

  19. Linfoma tipo MALT de la glándula parótida Lymphoma type MALT of the parotid gland

    Directory of Open Access Journals (Sweden)

    Carlos Frómeta Neira

    2010-09-01

    Full Text Available Los linfomas tipo MALT (tejido linfoideo asociado a mucosa, constituyen la variedad más recientemente descubierta de los linfomas no Hodgkin, tienen lugar fundamentalmente en la mucosa gástrica asociados a infección por Helycobacter pylori, y en la glándula tiroides en relación con la tiroiditis de Hashimoto. Sin embargo, internacionalmente se han descrito casos en glándulas salivales asociados a linfoadenitis. La naturaleza de la lesión a menudo no puede ser determinada solo por el estudio citológico; se hace necesario el análisis histopatológico para el diagnóstico definitivo en la mayoría de los casos. El presente estudio muestra un paciente masculino con aumento de volumen bilateral de ambas glándulas parótidas y diagnóstico citohistopatológico de un proceso linfoepitelial benigno, el cual desarrolló un linfoma tipo MALT en relación con la glándula parótida derecha.The lymphomas type MALT or the mucosa-associated lymphoid tissue, are the most recent variety of non-Hodgkin lymphomas present mainly in the gastric mucosa associated with Helycobacter pylori infection and in the thyroid gland in relation to Hashimoto's thyroiditis. Frequently the origin of this lesion can't be determined only by cytology study, thus it is necessary the histopathology analysis for a definitive diagnosis in most cases. Present paper includes the case of male patient with bilateral volume increase of both parotid glands and a diagnosis cytopathological of a benign lymphoepithelial process and the development of a type MALT lymphoma in relation to the right parotid gland.

  20. Linfoma não-Hodgkin em tireóide: relato de caso Non-Hodgkin's lymphoma in the thyroid: case report

    Directory of Open Access Journals (Sweden)

    Evandro de Azambuja

    2004-06-01

    Full Text Available Os autores relatam o caso de uma paciente do sexo feminino, 33 anos de idade, branca, sem evidência clínico-laboratorial de tireoidite ou hipotireoidismo clínico, que apresentou uma massa cervical de crescimento rápido. Através de exames histopatológico e imuno-histoquímico, foi realizado o diagnóstico de linfoma não-Hodgkin folicular em tireóide.The authors describe the case of a 33 year-old white female, without any clinical or laboratorial evidence of thyroiditis or clinical hypothyroidism, who presented with a rapidly enlarging anterior neck mass. Diagnosis of a follicular non-Hodgkin's lymphoma was made through histopathological and immunohistochemical analysis.

  1. Ictericia febril colestásica como forma de presentación de linfoma de Hodgkin

    Directory of Open Access Journals (Sweden)

    Max Schindler

    2014-02-01

    Full Text Available La ictericia febril colestásica como forma de presentación de los linfomas de Hodgkin es un cuadro muy infrecuente. Describimos aquí un caso de síndrome febril prolongado asociado a ictericia progresiva, en el que el diagnóstico de la enfermedad se realiza a través de la biopsia hepática, dada la ausencia de afectación ganglionar que caracteriza a esta enfermedad. Destacamos asimismo el cuadro clínico avanzado y el compromiso multisistémico de una enfermedad rápidamente evolutiva.

  2. Linfoma MALT de parótida, presentación de un caso clínico y revisión del tema Parotid MALT lymphoma, presentation of a clinical case and review of subject

    OpenAIRE

    Francisca Fernández A; Carlos Espinoza N; Víctor Mercado M; Humberto Vallejos A

    2012-01-01

    Los linfomas de las glándulas salivales son una entidad poco frecuente, estimándose una incidencia del 5%. La localización más habitual es la glándula parótida, seguida de la submaxilary la sublingual. La mayoría de los linfomas parotídeos son linfomas no Hodgkin (LNH) y se consideran derivados del tejido linfoide asociado a mucosas (MALT). Infrecuentemente se han reportado estos casos y suelen ser subdiagnosticados por su presentación relativamente benigna, comportándose de forma localizada,...

  3. Linfoma T subcutâneo do tipo paniculite: relato de um caso acometendo paciente pediátrico Subcutaneous panniculitic T cell lymphoma: a case report affecting a child

    OpenAIRE

    Lúcia de Noronha; Fabiola Medeiros; Luciano Monte Serrat Prevedello; Vanessa Dello Monaco Martins; Flora Watanabe; José Fillus Neto

    2001-01-01

    Os autores relatam um caso de linfoma T subcutâneo do tipo paniculite em uma paciente feminina de 3 anos, apresentando havia um mês múltiplos nódulos subcutâneos, indolores, disseminados no abdome, região peitoral e cervical. Ao exame histopatológico, evidenciou-se um linfoma T infiltrando tecido adiposo subcutâneo. Os linfomas T subcutâneos representam uma entidade clinicopatológica distinta, sendo raro o acometimento pediátrico.We report a case of lypotrophic lymphoma affecting a 3-year-old...

  4. tratados internacionales en América Latina

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    Víctor Bazán

    2006-01-01

    Full Text Available En este artículo el autor analiza las soluciones que, desde el plano de las respectivas normativas constitucionales, ofrece el derecho comparado de algunos países latinoamericanos en relación con la problemática del control de constitucionalidad de los tratados y convenios internacionales. En el trabajo se postula fundamentalmente que dicho contralor de constitucionalidad debe ser previo y obligatorio, en orden a prevenir contradicciones o disturbios normativos ad intra e intensificar, así, la búsqueda de la preservación de la supremacía constitucional; coadyuvar al mantenimiento de la coherencia y lógica del sistema de fuentes, y evitar la vinculación jurídica del Estado correspondiente en el ámbito internacional sin proceder, previamente, a las adecuaciones normativas pertinentes o, en su caso, a desistir de la aprobación del tratado o a concretarla con reservas, pues –entre diversos aspectos de la cuestión– la responsabilidad internacional del Estado está en juego.

  5. Infiltración meningea por leucemia a celulas plasmáticas y por linfoma no Hodgkin: estudio citomorfologico en el liquido cefalo-raquideo

    Directory of Open Access Journals (Sweden)

    Arnaldo Tabares Olives

    1982-06-01

    Full Text Available Son presentadas las características citomorfológicas anormales encontradas en el LCR de dos pacientes, uno de ellos sufriendo de leucemia aguda a células plasmáticas y otro de linfoma mixto no Hodgkin. Se enfatiza la importancia del estudio del LCR en estas patologias.

  6. Infiltración meningea por leucemia a celulas plasmáticas y por linfoma no Hodgkin: estudio citomorfologico en el liquido cefalo-raquideo

    OpenAIRE

    Arnaldo Tabares Olives

    1982-01-01

    Son presentadas las características citomorfológicas anormales encontradas en el LCR de dos pacientes, uno de ellos sufriendo de leucemia aguda a células plasmáticas y otro de linfoma mixto no Hodgkin. Se enfatiza la importancia del estudio del LCR en estas patologias.

  7. Linfoma intestinal em doente tratada com metotrexato (caso clínico

    Directory of Open Access Journals (Sweden)

    Ana Nunes

    2013-01-01

    Full Text Available A imunossupressão prolongada e as doenças inflamatórias crónicas são reconhecidos fatores de risco para o desenvolvimento de doenças linfoproliferativas. Estas podem, na fase inicial, ter manifestações clínicas pouco exuberantes, obrigando a uma especial atenção para a sua deteção precoce. Apresenta-se o caso de uma mulher de 69 anos, com passado de cirurgia e radioterapia pélvicas por adenocarcinoma do endométrio e com artrite reumatóide, tratada com metotrexato e prednisolona, referenciada à consulta por dor abdominal. A dor, inicialmente difusa e posteriormente localizada na fossa ilíaca direita (FID, acompanhava-se de astenia, anorexia e perda ponderal. Havia anemia e elevação da velocidade de sedimentação. A colonoscopia mostrou úlcera no cego e ulcerações superficiais no íleon terminal que foram biopsadas, tendo sido sugerido o diagnóstico de doença de Crohn. Verificou-se agravamento clínico com perda ponderal acentuada, episódios de suboclusão intestinal e aparecimento de massa na FID. Após realização de enterografia por ressonância magnética (RM e nova colonoscopia, foi estabelecido o diagnóstico de linfoma B difuso de grandes células. A doente suspendeu a imunossupressão e foi submetida a quimioterapia sistémica com R-CHOP, tendo sido conseguida remissão completa.

  8. Presentación clínica de los linfomas no hodgkinianos Clinical presentation of non-Hodgkin lymphomas

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    Calixto Hernández Cruz

    2003-12-01

    Full Text Available Se realizó un estudio retrospectivo en 644 pacientes con diagnóstico de linfoma no hodgkiniano atendidos en el Servicio de Hematología del Hospital "Hermanos Ameijeiras" con el objetivo de conocer las características clínicas y epidemiológicas de esta enfermedad al debut. La relación masculino femenino fue de 1,02 : 1; el 68,7 % eran de piel blanca; el grupo etáreo más afectado fue el de 55 - 74 años; la toma ganglionar predominó sobre la extraganglionar, con una mayor incidencia en la región cervical; la médula ósea fue la toma extraganglionar más común; la afectación extranodal primaria se presentó en el 15 % de los casos; los síntomas generales se detectaron en el 27,9 % de estos pacientes; la histología agresiva predominó sobre los indolentes y el tipo histológico más observado fue el difuso de células grandes. Al diagnóstico, el 66,1 % se encontraba en estadios avanzados. Se encontró significación estadística al relacionar el grado de agresividad con la presencia de síntomas generales y los estadiosA retrospective study was conducted in 644 patients with diagnosis of non-Kodgkin lymphoma that received attention at the service of Haematology of "Hermanos Ameijeiras" Hospital in order to know the clinical and epidemiological characteristics of this disease on its onset. The males females ratio was 1.02:1. 68.7 % were white and the age group 55-74 was the most affected. The ganglionar taking prevailed over the extraganglionar, with a higher incidence in the cervical region. The bone marrow was the most common extraganglionar taking. The primary extranodal affectation was present in 15 % of the cases. The general symptoms were detected in 27.9 % of these patients. Aggressive histology predominated among the indolents and the most observed histological site was the diffuse of large cells. On diagnosis, 66.1 % were in advanced stages. Statistical significance was found on relating the aggressiveness degree to the presence of general symptoms and stages

  9. Linfoma de células en anillo de sello que simula carcinoma mucosecretante / Signet ing cell lymphoma mimicking mucin-producing carcinoma

    Scientific Electronic Library Online (English)

    Ana María, Saenz de Chirife; Erica, Rojas Bilbao; Liliana, Gimenez; Lina, Marino; Francisco, Celeste.

    2004-12-01

    Full Text Available El linfoma de células en anillo de sello es una neoplasia poco frecuente, caracterizada por la presensencia de grandes células de citoplasma vacuolado, claro, similar a los encontrados en adeno-carcinomas mucosecretantes. Se ha descripto en ganglios linfáticos y tejidos extralinfáticos. Se presenta [...] el caso de un paciente varón de 59 años con linfoma de células en anillo de sello localizado en pared lateral de orofaringe. Esta localización creemos que no ha sido descripta anteriormente. La histología mostró células en anillo de sello y el inmunofenotipo tumoral fue: vimentina, CD45, CD20, Ig M y cadenas kappa positivos, siendo la fracción de crecimiento tumoral alta (Ki 67:70%). El paciente evolucionó desfavorablemente y falleció a los dos meses del diagnóstico sin recibir tratamiento. Abstract in english Signet ring cell lymphoma is a rare neoplasm caracterized by large, vacuolated and clear cells mimicking mucin-producing adenocarcinoma. It is localized in nodal and extranodal sites. A case of a 59 years old male, with a diffuse lymphoma signet ring cell type localized on oropharingeal mucosa is re [...] ported. The histopathology study showed signet ring cells and the immunophenotype was: vimentine(+), CD45(+), CD20(+), Ig M(+), Kappa chain(+) and high index proliferative activity of neoplastic cells (Ki 67:70%). After a review of the literature and previous reports, we could not find a similar case in this anatomic site. The patient had a unfavourable clinical course and died two months after the diagnosis without receiving any treatment.

  10. Linfoma de células en anillo de sello que simula carcinoma mucosecretante Signet ing cell lymphoma mimicking mucin-producing carcinoma

    Directory of Open Access Journals (Sweden)

    Ana María Saenz de Chirife

    2004-12-01

    Full Text Available El linfoma de células en anillo de sello es una neoplasia poco frecuente, caracterizada por la presensencia de grandes células de citoplasma vacuolado, claro, similar a los encontrados en adeno-carcinomas mucosecretantes. Se ha descripto en ganglios linfáticos y tejidos extralinfáticos. Se presenta el caso de un paciente varón de 59 años con linfoma de células en anillo de sello localizado en pared lateral de orofaringe. Esta localización creemos que no ha sido descripta anteriormente. La histología mostró células en anillo de sello y el inmunofenotipo tumoral fue: vimentina, CD45, CD20, Ig M y cadenas kappa positivos, siendo la fracción de crecimiento tumoral alta (Ki 67:70%. El paciente evolucionó desfavorablemente y falleció a los dos meses del diagnóstico sin recibir tratamiento.Signet ring cell lymphoma is a rare neoplasm caracterized by large, vacuolated and clear cells mimicking mucin-producing adenocarcinoma. It is localized in nodal and extranodal sites. A case of a 59 years old male, with a diffuse lymphoma signet ring cell type localized on oropharingeal mucosa is reported. The histopathology study showed signet ring cells and the immunophenotype was: vimentine(+, CD45(+, CD20(+, Ig M(+, Kappa chain(+ and high index proliferative activity of neoplastic cells (Ki 67:70%. After a review of the literature and previous reports, we could not find a similar case in this anatomic site. The patient had a unfavourable clinical course and died two months after the diagnosis without receiving any treatment.

  11. Linfoma não-Hodgkin endobrônquico Endobronchial involvement in non-Hodgkin’s lymphoma

    Directory of Open Access Journals (Sweden)

    Mauro Zamboni

    2004-02-01

    Full Text Available Os linfomas não-Hodgkin fazem parte de um grupo de doenças malignas linfoproliferativas com diferentes padrões de comportamento, de tratamento e de prognóstico. Eles podem comprometer as estruturas intratorácicas, particularmente o mediastino e o parênquima pulmonar, em alguma fase do curso da doença. Entretanto, o envolvimento endobrônquico é extremamente raro, mesmo na presença de doença avançada. Os autores relatam um caso de linfoma não-Hodgkin endobrônquico e fazem revisão da literatura.Non-Hodgkin’s lymphomas belong to a group of lymphoproliferative malignancies with different behavior, treatment and prognostic patterns. During the course of the disease, they may affect the thoracic structures - especially the mediastinum and the pulmonary parenchyma. However endobronchial involvement is extremely uncommon, even in presence of advanced disease. Here, we report a case of non-Hodgkin’s endobronchial lymphoma and make a review of the literature.

  12. Linfoma não-Hodgkin em adultos: perfil proteico do LCR e do soro de 25 doentes

    Directory of Open Access Journals (Sweden)

    MIELLI SYLVIA REGINA

    1998-01-01

    Full Text Available Vinte e cinco pacientes com linfoma não-Hodgkin estudados para detecção de sinais e sintomas de comprometimento neurológico foram investigados quanto ao perfil proteico do líquido cefalorraqueano (LCR. Amostras de LCR e de soro sanguíneo colhidas no mesmo período foram estudadas comparativamente para analisar a barreira hemato-encefálica e a produção intratecal de IgG .Em 48% dos doentes foram registradas queixas e/ou sinais ao exame neurológico. A análise demonstrou: aumento das proteínas totais no LCR em 52%; imunoliberação local em um paciente HIV soropositivo; aumento de globulinas gama no LCR de dois pacientes na ausência de células neoplásicas no LCR e melhora clínica pós-quimioterapia; e registro de banda oligoclonal apenas no LCR em um doente HTLV-I soropositivo. Esses dados mostram que o estudo do perfil proteico no LCR contribui para a caracterização das manifestações do linfoma não-Hodgkin no sistema nervoso.

  13. LINFOMAS PULMONARES: CORRELAÇÃO DA TOMOGRAFIA COMPUTADORIZADA DE ALTA RESOLUÇÃO COM A ANATOMOPATOLOGIA

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    Marchiori Edson

    2002-01-01

    Full Text Available Neste trabalho são descritos os aspectos tomográficos de alta resolução dos linfomas pulmonares e feita correlação com os achados anatomopatológicos. Com este objetivo, foram revisados as tomografias computadorizadas de alta resolução do tórax e os dados histopatológicos de dez pacientes com diagnóstico confirmado de linfoma não-Hodgkin ou de doença de Hodgkin. Os resultados obtidos foram confrontados com os descritos na literatura. Os achados radiológicos mais comumente vistos neste estudo foram as consolidações parenquimatosas, localizadas, com broncogramas aéreos de permeio (n = 8. Em menor freqüência, foram encontrados múltiplos nódulos parenquimatosos (n = 4, espessamento peribroncovascular (n = 3 e opacidades em vidro fosco (n = 2. Na correlação com a anatomia patológica, as consolidações corresponderam a preenchimento alveolar por células neoplásicas, o espessamento peribroncovascular se deveu a infiltração das bainhas peribroncovasculares por células linfomatosas e a atenuação em vidro fosco se associou com infiltração dos septos alveolares por tais células.

  14. Linfoma não-Hodgkin em crianças com imunodeficiência: relato de cinco casos Non-Hodgkin's lymphoma in children with immunodeficiency: report of five cases

    Directory of Open Access Journals (Sweden)

    Maria Christina L. A. Oliveira

    2008-01-01

    Full Text Available Neste estudo é relatado o quadro clínico de cinco crianças com linfoma não-Hodgkin secundário a imunodeficiência ou imunossupressão: três portadoras do vírus da imunodeficiência humana, uma com imunodeficiência primária e uma após transplante hepático. De acordo com a classificação atual, os tipos histológicos foram: linfoma linfoblástico de células B precursoras (2, linfoma cutâneo de grandes células anaplásico (1, linfoma de células B periféricas, sugestivo de Burkitt (1, e linfoma linfoblástico de células T precursoras (1. Todos os pacientes foram submetidos a quimioterapia, sendo que dois estão em remissão clínica, dois morreram e um continua em tratamento. Após a introdução da terapia anti-retroviral combinada e o aumento dos transplantes de órgãos sólidos ocorre maior risco de neoplasia nesses pacientes. Desse modo, é importante o seguimento desses pacientes para determinar os fatores de risco para o desenvolvimento de neoplasias e definir adequada estratégia de tratamento.The outcomes of five children with non-Hodgkin's lymphomas associated with immunodeficiency or immunosuppression is reported: three children with HIV, one with primary immunodeficiency and one after liver transplantation. According to the REAL classification, two patients had precursor B-lymphoblastic lymphomas, one had an anaplastic large cell lymphoma, one had a peripheral B-cell neoplasm suggestive of Burkitt's lymphoma, and one had precursor T-lymphoblastic lymphoma. All patients received chemotherapy. Two are in complete remission, two died and one remains under treatment. There has been an increasing awareness of the risk of non-Hodgkin's lymphoma and lymphoproliferative disorders after active antiretroviral therapy and with the expansion of solid organ transplant programs in the pediatric setting. Thus, for these patients it is important to establish risk factors for hematological disorders and determine the optimal and safest treatment.

  15. Bothrops jararaca envenomation: Pathogenesis of hemostatic disturbances and intravascular hemolysis.

    Science.gov (United States)

    Senise, Luana V; Yamashita, Karine M; Santoro, Marcelo L

    2015-11-01

    To attain fully functional biological activity, vitamin-K dependent coagulation factors (VKDCF) are γ-carboxylated prior to secretion from liver. Warfarin impairs the γ-carboxylation, and consequently their physiological function. Bothrops jararaca snake venom (BjV) contains several activators of blood coagulation, especially procoagulant enzymes (prothrombin and factor X activators) and thrombin-like enzymes. In order to clarify the relative contribution of prothrombin and factor X activators to the hemostatic disturbances occurring during experimental B. jararaca envenomation, warfarin was used to deplete VKDCF, prior to BjV administration. Male Wistar rats were pretreated with saline (Sal) or warfarin (War) and inoculated subsequently with BjV or saline, thus forming four groups: Sal + Sal (negative control), Sal + BjV (positive control), War + Sal (warfarinization control), and War + BjV. Three hours after inoculation, prothrombin and factor X levels fell 40% and 50%, respectively; levels of both factors decreased more than 97% in the War + Sal and War + BjV groups. Platelet counts dropped 93% and 76% in Sal + BjV and War + BjV, respectively, and plasma fibrinogen levels decreased 86% exclusively in Sal + BjV. After 6 and 24 h, platelet counts and fibrinogen levels increased progressively. A dramatic augmentation in plasma hemoglobin levels and the presence of schizocytes and microcytes in the Sal + BjV group indicated the development of intravascular hemolysis, which was prevented by warfarin pretreatment. Our findings show that intravascular thrombin generation has the foremost role in the pathogenesis of coagulopathy and intravascular hemolysis, but not in the development of thrombocytopenia, in B. jararaca envenomation in rats; in addition, fibrinogenases (metalloproteinases) may contribute to coagulopathy more than thrombin-like enzymes. PMID:26080462

  16. Venous gas embolism - Time course of residual pulmonary intravascular bubbles

    Science.gov (United States)

    Butler, B. D.; Luehr, S.; Katz, J.

    1989-01-01

    A study was carried out to determine the time course of residual pulmonary intravascular bubbles after embolization with known amounts of venous air, using an N2O challenge technique. Attention was also given to the length of time that the venous gas emboli remained as discrete bubbles in the lungs with 100 percent oxygen ventilation. The data indicate that venous gas emboli can remain in the pulmonary vasculature as discrete bubbles for periods lasting up to 43 + or - 10.8 min in dogs ventilated with oxygen and nitrogen. With 100 percent oxygen ventilation, these values are reduced significantly to 19 + or - 2.5 min.

  17. Histamine release and endothelial leakage from an intravascular contrast medium

    Energy Technology Data Exchange (ETDEWEB)

    Raininko, R.

    1981-04-01

    The endothelial injury produced by meglumine iodamide was studied in the rat aorta. A mixture of blood and contrast medium was more toxic to the endothelium than the pure contrast agent. This difference disappeared after premedication with antihistamine, which did not affect the injury produced by the pure contrast agent. Meglumine iodamide appears to cause a release of histamine from blood but not from the aortic endothelium nor from surrounding tissues in amounts demonstrable by this method. Leucocytes are a source of histamine after intravascular contrast medium administration.

  18. Microbubble-mediated intravascular ultrasound imaging and drug delivery.

    Science.gov (United States)

    Dixon, Adam J; Kilroy, Joseph P; Dhanaliwala, Ali H; Chen, Johnny L; Phillips, Linsey C; Ragosta, Michael; Klibanov, Alexander L; Wamhoff, Brian R; Hossack, John A

    2015-09-01

    Intravascular ultrasound (IVUS) provides radiation-free, real-time imaging and assessment of atherosclerotic disease in terms of anatomical, functional, and molecular composition. The primary clinical applications of IVUS imaging include assessment of luminal plaque volume and real-time image guidance for stent placement. When paired with microbubble contrast agents, IVUS technology may be extended to provide nonlinear imaging, molecular imaging, and therapeutic delivery modes. In this review, we discuss the development of emerging imaging and therapeutic applications that are enabled by the combination of IVUS imaging technology and microbubble contrast agents. PMID:26415129

  19. Method for Observing Intravascular BongHan Duct

    CERN Document Server

    Jiang, X; Shin, H; Lee, B; Choi, C; Soh, K; Cheun, B; Baik, K; Soh, K; Jiang, Xiaowen; Kim, Hee-kyeong; Shin, Hak-soo; Lee, Byong-chon; Choi, Chunho; Soh, Kyung-soon; Cheun, Byeung-soo; Baik, Ku-youn; Soh, Kwang-sup

    2002-01-01

    A method for observing intra blood vessel ducts which are threadlike bundle of tubules which form a part of the BongHan duct system. By injecting 10% dextrose solution at a vena femoralis one makes the intravascular BongHan duct thicker and stronger to be easily detectable after incision of vessels. The duct is semi-transparent, soft and elastic, and composed of smaller tubules whose diameters are of 10$\\mu$m order, which is in agreement with BongHan theory.

  20. Brachytherapy optimal planning with application to intravascular radiation therapy

    DEFF Research Database (Denmark)

    Sadegh, Payman; Mourtada, Firas A.; Taylor, Russell H.; Anderson, James H.

    1999-01-01

    We have been studying brachytherapy planning with the objective of manimizing the maximum deviation of the delivered dose from prescribed dose bounds for treatment volumes. A general framework for optimal treatment planning is presented and the minmax optimization is formulated as a linear program....... Dose rate calculations are based on the sosimetry formulation of the American Association of Physicists in Medicine, Task Group 43. We apply the technique to optimal planning for intravascular brachytherapy of intimal hyperplasia using ultrasound data and 192Ir seeds. The planning includes...

  1. Prevention of adverse reactions to intravascular contrast media

    International Nuclear Information System (INIS)

    The exact mechanisms of adverse reactions to contrast media are still imperfectly known. However, these reactions may be classified as idiosyncratic. Non-idiosyncratic reactions can be prevented by using new, non-ionic contrast agents. Idiosyncratic reactions can be prevented by specific premedication. Patients with a history of idiosyncratic reaction may benefit from corticosteroids and antihistamines administered prophylactically. Patients who seem to be more likely than others to react to contrast media must be premedicated, the risk of reaction being identified and evaluated by questioning. It has recently been suggested that all patients about to receive an intravascular injection of contrast medium should also be premedicated

  2. Histamine release and endothelial leakage from an intravascular contrast medium

    International Nuclear Information System (INIS)

    The endothelial injury produced by meglumine iodamide was studied in the rat aorta. A mixture of blood and contrast medium was more toxic to the endothelium than the pure contrast agent. This difference disappeared after premedication with antihistamine, which did not affect the injury produced by the pure contrast agent. Meglumine iodamide appears to cause a release of histamine from blood but not from the aortic endothelium nor from surrounding tissues in amounts demonstrable by this method. Leucocytes are a source of histamine after intravascular contrast medium administration. (orig.)

  3. Alterações vasculares na coróide de ratos diabéticos tratados e não tratados Choroidal vessels alterations in treated and untreated diabetic rats

    Directory of Open Access Journals (Sweden)

    Antonio Carlos Lottelli Rodrigues

    2007-06-01

    Full Text Available OBJETIVO: Conhecer os efeitos do diabetes e o impacto de seu tratamento medicamentoso em curto e longo prazo sobre os vasos da coróide e membrana de Bruch. MÉTODOS: Foram estudados 30 ratos Wistar, divididos em 3 grupos experimentais: grupo controle (GC, grupo diabético (GD e grupo diabético tratado (GT, estudados 1 mês (momento M1 e 12 meses (momento M2 após o início do experimento. O diabetes foi induzido por aloxana endovenosa, na dose de 42 mg/kg. O GT foi tratado com hipoglicemiante oral (acarbose e insulina subcutânea. Após o sacrifício, os olhos foram preparados para exame ao microscópio eletrônico de transmissão, interessando a ultra-estrutura da membrana de Bruch e os vasos da coróide. RESULTADOS: O exame ultra-estrutural da coróide dos ratos diabéticos mostrou depósitos na membrana de Bruch, acúmulo de vesículas, glicogênio e corpos densos no citoplasma das células endoteliais. O grupo mais afetado foi de ratos diabéticos de 12 meses (GDM2. Os animais com menor intensidade de alterações foram os ratos tratados por 12 meses (GTM2. CONCLUSÃO: Os ratos diabéticos desenvolveram alterações degenerativas na membrana de Bruch e vasos da coróide. Estas alterações foram mais evidentes nos animais submetidos à doença crônica, mas também ocorreram agudamente. O tratamento a curto prazo não foi capaz de evitar os processos degenerativos. A longo prazo, o tratamento inibiu a progressão destes processos.PURPOSE: To evaluate the diabetic alterations and the impact of short and long-term medical treatment on them. METHODS: Thirty Wistar rats were divided into 3 groups: control (GC, diabetic (DG, and treated diabetic (TG and the observations were made 1 month (M1 and 12 months (M2 after diabetes induction. Diabetes was induced by intravenous alloxan (42 mg/kg. The treated group received acarbose orally and insulin by subcutaneous injection. Eyes were prepared for transmission electron microscopy, specifically for ultrastructure of the Bruch membrane and choroidal vessels. RESULTS: Ultrastructural examination of the diabetic rat coroid showed deposits in the Bruch membrane and accumulation of vesicles, glycogen and dense bodies in endothelial cell cytoplasm. The most affected group was that of the diabetics on month 12 (GDM2. The treated diabetics showed the least alterations on month 12 (GTM2. CONCLUSION: Diabetic rats develop degenerative alterations in the Bruch membrane and choroidal vessels. These alterations are more evident in animals submitted to chronic disease, but they are also present in acute disease. Degenerative processes were not avoided with short-term treatment. Long-term treatment inhibited the progress of these processes.

  4. Intravascular Papillary Endothelial Hyperplasia(Masson's Tumor) of the Chest Wall: A Case Report

    International Nuclear Information System (INIS)

    Intravascular papillary endothelial hyperplasia is a rare tumor-like lesion caused by hyperplastic proliferation of endothlial cells that is usually an incidental findings within thrombosed dilated blood vessels or vascular tumor. We report the sonographic appearance and pathological correlation of intravascular papillary endothelial hyperplasia that presented as an intramuscular solitary mass in chest wall

  5. Estudio histológico e inmunofenotípico de linfoma canino en el centro de México / Histological and immunophenotypic study of canine lymphoma in the center of Mexico

    Scientific Electronic Library Online (English)

    Francisco J., Álvarez Berger; Enrique, Aburto Fernández; Aristi Urista, Gerardo; Gilberto, Chávez Gris.

    2009-06-01

    Full Text Available El inmunofenotipo constituye un factor importante en el pronóstico del linfoma canino. Se ha demostrado que perros con linfoma de células B presentan tiempos de sobrevivencia más largos que los perros con linfoma de células T. Los antígenos CD3 y CD79a son los marcadores más utilizados en inmunohist [...] oquímica para la determinación del fenotipo celular T y B, respectivamente, en muestras fijadas en formalina y conservadas en bloques de parafina. En este estudio se describen las características morfológicas e inmunofenotípicas de 31 casos de linfoma en México, de casos del archivo del Departamento de Patología de la Facultad de Medicina Veterinaria y Zootecnia de la Universidad Nacional Autónoma de México. Para la clasificación histológica se utilizó el sistema del National Cancer Institute-Working Formulation (NCI-WF). Catorce casos (45.16%) correspondieron a células B, 15 (48.39%) a células T, y dos (6.45%) fueron de origen indeterminado. Histopatológicamente, el linfoma difuso de células grandes fue el tipo más común, representó 38.71% de los casos; le siguieron los siguientes linfomas: linfocítico, inmunoblástico y linfoblástico. Los linfomas de grado intermedio a alto representaron 77.42% de los casos. En este estudio se encontró mayor prevalencia de linfoma de células T. Los resultados en este trabajo pudieran indicar una diferencia en la prevalencia en el inmunofenotipo del linfoma canino en México, en relación con otras zonas geográficas. Abstract in english Immunophenotype constitutes an important factor in the prognosis of canine lymphoma. It has been demonstrated that dogs with B-cell lymphomas have a longer life span than those with T-cell lymphomas. CD3 and CD79a antigens are the most common markers used for the immunohistochemical determination of [...] T-cell and B-cell on formalin-fixed paraffin wax-embedded canine lymphoma tissues. This study describes the morphological and immunophenotypic characteristics of 31 cases of lymphoma in Mexico, obtained from file of the Pathology Department of Veterinary Medicine and Animal Husbandry Faculty of the National Autonomous University of Mexico. The National Cancer Institute-Working Formulation (NCI-WF) classification system was used for the histological classification. Fourteen cases (45.16%) were B cell origin, 15 cases (48.39%) were T-cell origin and 2 cases (6.45%) presented an indeterminate origin. Histopathological diffuse large cell lymphoma (DL) was the most common found (38.71%), followed by lymphocytic (DSL), immunoblastic (IB), intermediate and high-grade lymphomas represented 77.42% of the cases. In this study there was higher prevalence of T-cell lymphoma. The results in this work could indicate prevalent differences in the immunophenotype of the canine lymphoma in Mexico compared with other geographical areas.

  6. Fatal Cryocrystalglobulinemia With Intravascular and Renal Tubular Crystalline Deposits.

    Science.gov (United States)

    DeLyria, Paul A; Avedschmidt, Sarah E; Yamada, Chisa; Farkash, Evan A

    2016-05-01

    Cryocrystalglobulinemia is a rare variant of cryoglobulinemia in which monoclonal immunoglobulins self-assemble into crystalline arrays. We report a case of a 53-year-old man who presented with systemic thrombotic microangiopathy causing multiorgan failure, including decreased kidney, lung, and gastrointestinal function; skin necrosis; and mental status changes. Skin and kidney biopsy specimens showed intravascular thrombi, along with intravascular, intratubular, and periglomerular crystalline deposits. Typical morphologic features of cryoglobulinemia, such as a leukocytoclastic vasculitis and pseudothrombi, were absent. Spindled crystals precipitated in the cryoglobulin assay, and immunofixation showed them to be composed of monoclonal immunoglobulin G κ light chains. Ultrastructural analysis demonstrated deposits to have an array-like substructure. The patient was successfully treated with a combination of plasmapheresis, steroids, and bortezomib, but experienced a relapse and died 12 months after his initial diagnosis. Cryocrystalglobulinemia causes significant morbidity and mortality and should be classified as a monoclonal gammopathy of renal significance when it occurs in patients not meeting diagnostic criteria for multiple myeloma. PMID:26775022

  7. Development of {sup 192}Ir radiation sources for intravascular irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Kogure, Hiroto; Sorita, Takami; Iwamoto, Seikichi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Nagata, Yasushi; Hiraoka, Masahiro [Kyoto Univ., Kyoto (Japan); Iwata, Kazuro [Nara Medical Univ., Nara (Japan); Kawauchi, Yukimasa; Suzuki, Kazutoshi [Chiyoda Technol Corp., Tokyo (Japan)

    2003-03-01

    Intravascular brachytherapy is a novel therapy for preventing the restenosis of coronary artery by use of low-dose irradiation. JAERI and Kyoto University have been developing {sup 192}Ir radiation sources by the cooperative research project entitled as 'The research on safety and effectiveness of the intravascular brachytherapy for preventing restenosis of the coronary artery disease' since 1998. The radiation source was introduced into the stenosis through a catheter (a guide-tube to insert directly into vascular) to irradiate the diseased part. Ten {sup 192}Ir seed sources ({phi}0.4 mm x 2.5 mm) were positioned between nylon spacers ({phi}0.3 mm x 1.0 mm) in a flexible covering tube and the tube was plugged with a core-wire; the tube was shrunk to fix the inside materials and the size is 0.46 mm in diameter and 3 m in length. The physically optimal design was determined to insert the radiation source easily into vascular and to get the dose uniformity in the diseased part. The production method of the radiation source, which is practical to use in the clinics was also established. (author)

  8. Development of catheters for combined intravascular ultrasound and photoacoustic imaging

    Science.gov (United States)

    Karpiouk, Andrei B.; Wang, Bo; Emelianov, Stanislav Y.

    2009-02-01

    Coronary atherosclerosis is a complex disease accompanied by the development of plaques in the arterial wall. Since the vulnerability of the plaques depends on their composition, the appropriate treatment of the arteriosclerosis requires a reliable characterization of the plaques' geometry and content. The intravascular ultrasound (IVUS) imaging is capable of providing structural details of the plaques as well as some functional information. In turn, more functional information about the same plaques can be obtained from intravascular photoacoustic (IVPA) images since the optical properties of the plaque's components differ from that of their environment. The combined IVUS/IVPA imaging is capable of simultaneously detecting and differentiating the plaques, thus determining their vulnerability. The potential of combined IVUS/IVPA imaging has already been demonstrated in phantoms and ex-vivo experiments. However, for in-vivo or clinical imaging, an integrated IVUS/IVPA catheter is required. In this paper, we introduce two prototypes of integrated IVUS/IVPA catheters for in-vivo imaging based on a commercially available single-element IVUS imaging catheter. The light delivery systems are developed using multimode optical fibers with custom-designed distal tips. Both prototypes were tested and compared using an arterial mimicking phantom. The advantages and limitations of both designs are discussed. Overall, the results of our studies suggest that both designs of integrated IVUS/IVPA catheter have a potential for in-vivo IVPA/IVUS imaging of atherosclerotic plaques.

  9. Intravascular hypothermia for acute hemorrhagic stroke: a pilot study.

    Science.gov (United States)

    Abdullah, Jafri Malin; Husin, Andrean

    2011-01-01

    The use of intravascular hypothermia in the treatment of hemorrhagic stroke is currently still being researched. The exact therapeutic properties and effect of hypothermia on the natural progression of the disease are not known, and a only small number of papers has been published with results from these studies. Mild hypothermia at 34°C was induced in six patients with hemorrhagic stroke in the first 48 h after presentation, using an intravascular catheter placed in the inferior vena cava. The hypothermia was induced and maintained for 24 h followed by gradual rewarming. Another 18 patients with hemorrhagic stroke but not receiving hypothermia were then taken as the control group, and all patients were treated with standard stroke management. The patients were then followed up using the modified Rankin Scale (mRS) for 6 months and 1 year. There was a statistically significant improvement at 6 months and 1 year follow-up using the mRS score in the hypothermia group, indicating a possible beneficial effect of early therapeutic hypothermia in the management of acute hemorrhagic stroke. However, a larger study is needed in order to confirm our finding. PMID:21725794

  10. Focused intravascular ultrasonic probe using dimpled transducer elements.

    Science.gov (United States)

    Chen, Y; Qiu, W B; Lam, K H; Liu, B Q; Jiang, X P; Zheng, H R; Luo, H S; Chan, H L W; Dai, J Y

    2015-02-01

    High-frequency focused intravascular ultrasonic probes were fabricated in this study using dimple technique based on PMN-PT single crystal and lead-free KNN-KBT-Mn ceramic. The center frequency, bandwidth, and insertion loss of the PMN-PT transducer were 34 MHz, 75%, and 22.9 dB, respectively. For the lead-free probe, the center frequency, bandwidth, and insertion loss were found to be 40 MHz, 72%, and 28.8 dB, respectively. The ultrasonic images of wire phantom and vessels with good resolution were obtained to evaluate the transducer performance. The -6 dB axial and lateral resolutions of the PMN-PT probe were determined to be 58 μm and 131 μm, respectively. For the lead-free probe, the axial and lateral resolutions were found to be 44 μm and 125 μm, respectively. These results suggest that the mechanical dimpling technique has good potential in preparing focused transducers for intravascular ultrasound applications. PMID:25108608

  11. Late adverse reactions to intravascular iodinated contrast media

    International Nuclear Information System (INIS)

    Late adverse reactions to intravascular iodinated contrast media are defined as reactions occurring 1 h to 1 week after contrast medium injection. They have received increasing interest over the past decade, but their prevalence remains uncertain and their pathophysiology is not fully understood. The Contrast Media Safety Committee of the European Society of Urogenital Radiology decided to review the literature and to issue guidelines. An extensive literature search was carried out and summarized in a report. Based on the available information, simple guidelines have been drawn up. The report and guidelines were discussed at the 8th European Symposium on Urogenital Radiology in Genoa. Late adverse reactions after intravascular iodinated contrast medium include symptoms such as nausea, vomiting, headache, itching, skin rash, musculoskeletal pain, and fever. A significant proportion of these reactions is unrelated to the contrast medium; however, allergy-like skin reactions are well-documented side effects of contrast media with an incidence of approximately 2%. Late reactions appear to be commoner after non-ionic dimers. The majority of late skin reactions after contrast medium exposure are probably T-cell-mediated allergic reactions. Patients at increased risk of late skin reactions are those with a history of previous contrast medium reaction and those on interleukin-2 treatment. Most skin reactions are self-limiting and resolve within a week. Management is symptomatic and similar to the management of other drug-induced skin reactions. (orig.)

  12. Doença de Behçet e linfoma. Associação fortuita?

    OpenAIRE

    J. Ferreira; Gonçalves, F.; Correia, J.; L. Xavier; Farrajota, P.

    2012-01-01

    A doença de Behçet (DB) caracteriza-se, classicamente, por uma tríade sintomática de úlceras orais recorrentes, úlceras genitais e uveíte. A DB é sistémica, com desenvolvimento de lesões vasculíticas ou vasculopáticas nas áreas afectadas. Estas áreas podem apresentar evidência microscópica de infiltração tecidual com células T e neutrófilos. A associação com Linfoma não-Hodgkin tem sido reportada em raros casos, não permitido afirmar relação causal. Reportamos um ca...

  13. Linfoma primario de páncreas en un paciente de 27 anos de edad. Reporte de un caso

    Directory of Open Access Journals (Sweden)

    Andrea Fargier Paoli

    2013-01-01

    Full Text Available Los linfomas representan una pequeña fracción de todas las neoplasias malignas de páncreas, siendo inferior al 1 o 2%, y es aún más extremadamente extraño en individuos menores de 35 años, por lo que presentamos caso de linfoma primario de páncreas en un paciente de 27 años de edad, que presentó ictericia y dolor abdominal, como única sintomatología. El ultrasonido abdominal solo reportó litiasis biliar mixta, por lo que se programó cirugía electiva para colecistectomía y exploración biliar. El hallazgo intraoperatorio inesperadamente indicó una tumoración a nivel de cabeza del páncreas, y se procedió a realizar una biopsia de la lesión, colecistectomía e inserción de tubo de Kher en la vía biliar principal, ante la imposibilidad de manejo endoscópico posterior con endoprotesis. Adicionalmente, se inicio un protocolo de estudio postoperatorio, hacia la búsqueda de marcadores tumorales y tomografía axial computarizada (TAC abdomino-pélvica, esta última evidenció tumoración en cabeza de páncreas sin infiltración a órganos vecinos o estructuras vasculares. El estudio histopatológico mostro un linfoma de páncreas, por lo que se complementaron los estudios de extensión e inició tratamiento a base de quimioterapia. En la actualidad tiene 6 meses de tratamiento con adecuada respuesta al mismo, dada por una disminución en el tamaño del tumor corroborada por tomografía y desaparición de la ictericia. Debido a los pocos casos reportados de linfoma primario de páncreas en individuos menores de 35 años, decidimos reportar este caso a fin evidenciar la importancia de un diagnóstico preoperatorio correcto, para evitar terapéuticas inadecuadas. Primary Lymphoma of Pancreas in a 27 year-old patient. A case report Abstract Pancreatic lymphomas is a rare (less than 1-2% pancreatic malignant neoplasms, but is extremely rare in under 35 yearsold. A rare case of Primary Lymphoma of Pancreas in a 27 years old patient is described, who was initially treated for abdominal pain and jaundice. Ultrasonographic images showed a mixt biliary stone disease, and he was taken to operation room for elective cholecystectomy and biliary exploration. We found a large tumor in pancreatic head, and we decided to take a biopsy specimen retrieval, cholecystectomy and Kher tube insertion in chodelocus. A serum oncologic markers and CT scan was performed as a postoperatory studies. A pancreatic head tumor without any evidence of adjacent or vascular structures infiltration was found. Pathology report showed a primary pancreatic lymphoma and adjuvant chemotherapy was initiated. Six months after surgery and chemotherapy treatment, a diminished size of the tumor was showed by CT and no jaundice was reported. Because of the exceedingly rare in patients younger than 35 year-old, we decided to report it, in order to accurate preoperative diagnosis and treatment.

  14. Linfoma Burkitt del seno esfenoidal en pediatría: Reporte de caso Burkitt Lymphoma of the Sphenoid Sinus in Children: Case Report

    Directory of Open Access Journals (Sweden)

    Jorge Docampo

    2011-06-01

    Full Text Available Se reporta un caso de linfoma Burkitt del seno esfenoidal en un paciente de sexo masculino, de 3 años de edad, de raza caucásica. Presentaba un cuadro clínico de 10 días de evolución con deterioro del sensorio, vómitos y amaurosis bilateral y, por tomografía computada y resonancia magnética, se identificó una masa que comprometía el seno esfenoidal. Se arribó al diagnóstico por anatomía patológica e inmunomarcación.We report a case of Burkitt lymphoma of the sphenoid sinus in a 3 year-old caucasian male patient. He presented a clinical condition of 10 days of improvement with a sensory deterioration, vomiting and bilateral amaurosis. A mass which compromised the sphenoid sinus was identified by computed tomography and magnetic resonance imaging. The diagnosis could be reached by pathology and immunohistochemical studies.

  15. Linfoma de Hodgkin em baixa faixa etária: relato de dois casos Hodgkin's lymphoma in young children: two cases report

    Directory of Open Access Journals (Sweden)

    Silvia M. Luporini

    2006-12-01

    Full Text Available Relato de dois casos de pacientes do sexo masculino com linfoma de Hodgkin (LH e idades inferiores a 5 anos apresentando linfonodomegalias com evolução de alguns meses e seguimento em nosso serviço. Os estudos imuno-histopatológicos do tumor confirmaram linfoma de Hodgkin, esclerose nodular e positividade para o vírus Epstein-Barr (EBV em material tumoral, em ambos os casos. Após período de 13 meses em remissão completa houve recidiva em um dos pacientes, mostrando doença agressiva. A análise laboratorial do tumor mostrou as mesmas características da doença inicial, e mantendo a positividade ao EBV. Uma exposição mais precoce e intensa ao EBV poderia aumentar o risco para formas muito precoces da doença e a inesperada evolução poderia estar ligada à associação do subtipo histológico e positividade ao EBV.The cases of two male under five-year-olds diagnosed with Hodgkin's lymphoma presenting as lymphadenopathy in evolution for some months and treated in our hospital are reported. Immunohistopathological findings of the tumors proved the existence of Hodgkin's lymphoma nodular sclerosis and positive Epstein-Barr virus in tumoral material in both cases. After 13 months of complete remission one of the patients relapsed and presented aggressive disease. Laboratorial analyses of the tumor showed the same characteristics as the initial disease including positive Epstein-Barr virus. Early and intense exposure to Epstein-Barr virus may increase the risk related to the very early development of the disease and the unexpected evolution may be connected to the association of the histological subtype and the positive Epstein-Barr virus.

  16. Contribuição da medicina nuclear para a avaliação dos linfomas

    Directory of Open Access Journals (Sweden)

    Sapienza Marcelo T.

    2001-01-01

    Full Text Available A medicina nuclear permite a caracterização funcional de tecidos, acrescentando dados à avaliação anatômica realizada por outros métodos de imagem, como a tomografia computadorizada, ressonância magnética ou ultra-som. Além do diagnóstico e estadiamento, as informações funcionais fornecidas pela medicina nuclear são particularmente úteis no seguimento e avaliação de resposta terapêutica dos pacientes com linfoma. A presença de massa residual após quimioterapia ou a infiltração de linfonodos de pequenas dimensões são exemplos de situações nas quais a avaliação isolada de características anatômicas é insuficiente. Os principais métodos utilizados são a cintilografia com gálio-67, traçador com alta afinidade por transferrina e receptores de ferro, e os estudos com flúor-deoxiglicose, emissor de pósitron que permite a caracterização do metabolismo de glicose nos tecidos. Outros traçadores, como o tálio-201, sestamibi-Tc99m e octreotide-In111, também são utilizados em menor escala na avaliação dos pacientes com linfoma. Os mecanismos de captação, principais indicações dos estudos, limitações e resultados de literatura serão revistos.

  17. El Tratado De Dilectione Dei de Balduino de Ford

    Scientific Electronic Library Online (English)

    Carlos, Hallet.

    Full Text Available Figura relevante de la Orden del Císter, Balduino de Ford es un autor que se distingue por la originalidad de su espiritualidad. Su tratado De dilectione Dei es una meditación sobre el Primer Mandamiento, que nos invita a amar a Dios "con todo el corazón en sus beneficios, con toda el alma en sus pr [...] omesas, con todas las fuerzas en sus juicios y con toda la mente en sus preceptos". Su reflexión, nutrida de la Biblia y expresada en un lenguaje marcado por la retórica latina, insiste en que el amor perfecto exige del creyente amar lo que a Dios le agrada porque a Él le agrada. Termina identificando prácticamente amor con obediencia Abstract in english Famous figure of the cistercian order, Baldwin of Ford is an author who stands out for the originality of his spirituality. His treatise "De dilectione Dei" is a meditation about the First Comandment, which is an invitation to love God "with all the heart in His benefits, with all the soul in His pr [...] omises, with all the forces in His judgements and with all the mind in His precepts". According to his reflection, fed with the Bible and expressed in a language marked by the latin rhetoric, the perfect love requires to love what is pleasing to God because it pleases Him. Baldwin practically identifies love with obedience

  18. El Tratado De Dilectione Dei de Balduino de Ford

    Directory of Open Access Journals (Sweden)

    Carlos Hallet

    2004-01-01

    Full Text Available Figura relevante de la Orden del Císter, Balduino de Ford es un autor que se distingue por la originalidad de su espiritualidad. Su tratado De dilectione Dei es una meditación sobre el Primer Mandamiento, que nos invita a amar a Dios "con todo el corazón en sus beneficios, con toda el alma en sus promesas, con todas las fuerzas en sus juicios y con toda la mente en sus preceptos". Su reflexión, nutrida de la Biblia y expresada en un lenguaje marcado por la retórica latina, insiste en que el amor perfecto exige del creyente amar lo que a Dios le agrada porque a Él le agrada. Termina identificando prácticamente amor con obedienciaFamous figure of the cistercian order, Baldwin of Ford is an author who stands out for the originality of his spirituality. His treatise "De dilectione Dei" is a meditation about the First Comandment, which is an invitation to love God "with all the heart in His benefits, with all the soul in His promises, with all the forces in His judgements and with all the mind in His precepts". According to his reflection, fed with the Bible and expressed in a language marked by the latin rhetoric, the perfect love requires to love what is pleasing to God because it pleases Him. Baldwin practically identifies love with obedience

  19. Evaluation of Disseminated Intravascular Coagulation in the Craniocerebral Traumas

    Directory of Open Access Journals (Sweden)

    Faruk Altinel

    2014-06-01

    Full Text Available Traumatic injury is one of the most important cause of disseminated intravascular coagulation (DIC. It occurs because of blood loss and hemodilution due to fluid resuscitation. The incidence of trauma associated DIC is mainly higher in the craniocerebral traumas. Even though craniocerebral trauma related DIC is well defined, the pathophysiology has been poorly characterized in the literature. Due to the fact that brain tissue is highly significant for procoagulant molecules, craniocerebral traumas are closely related to DIC. In the current study, 30 patients admitted to emergency room have been considered on the first and fifth day of admission to the hospital for the coagulation tests to evaluate DIC in both two groups. [Cukurova Med J 2014; 39(3.000: 488-495

  20. [Two cases of intravascular lymphoma diagnosed by random liver biopsy].

    Science.gov (United States)

    Hoshi, Tomoko; Fujii, Yoshinori; Okuyama, Shunsuke; Tanaka, Yuichi; Kimura, Noboru; Mouri, Youichi; Takaya, Haruo; Kajimura, Kouzou

    2014-07-01

    The pathogenesis of intravascular lymphoma (IVL) remains inadequately understood. Furthermore, its prognosis remains extremely poor despite combination chemotherapy. Lymphoma cells and hemophagocytosing cells are commonly observed in the livers of IVL patients and less frequently in the bone marrow. We recently encountered an 83-year-old female and a 78-year-old female with IVL, both of whom presented with fever of unknown origin. Following examination, we decided to perform random liver biopsy for diagnostic purposes. The former patient died because of rapid tumor growth, while the latter achieved remission following treatment with a modified R-VNCOP-B (etoposide, mitoxantrone, cyclophosphamide, vincristine, prednisolone, and bleomycin plus rituximab) regimen. Considering the possibility of IVL is important when examining a patient presenting with fever of unknown origin. This report demonstrates that random liver biopsy represents a useful diagnostic strategy, particularly in patients with elevated liver enzyme levels. PMID:24998735

  1. Robust intravascular optical coherence elastography by line correlations

    International Nuclear Information System (INIS)

    We present a new method for intravascular optical coherence elastography, which is robust against motion artefacts. It employs the correlation between adjacent lines, instead of subsequent frames. Pressure to deform the tissue is applied synchronously with the line scan rate of the optical coherence tomography (OCT) instrument. The viability of the method is demonstrated with a simulation study. We find that the root mean square (rms) error of the displacement estimate is 0.55 μm, and the rms error of the strain is 0.6%. It is shown that high-strain spots in the vessel wall, such as observed at the sites of vulnerable atherosclerotic lesions, can be detected with the technique

  2. Adaptive Estimation of Intravascular Shear Rate Based on Parameter Optimization

    Science.gov (United States)

    Nitta, Naotaka; Takeda, Naoto

    2008-05-01

    The relationships between the intravascular wall shear stress, controlled by flow dynamics, and the progress of arteriosclerosis plaque have been clarified by various studies. Since the shear stress is determined by the viscosity coefficient and shear rate, both factors must be estimated accurately. In this paper, an adaptive method for improving the accuracy of quantitative shear rate estimation was investigated. First, the parameter dependence of the estimated shear rate was investigated in terms of the differential window width and the number of averaged velocity profiles based on simulation and experimental data, and then the shear rate calculation was optimized. The optimized result revealed that the proposed adaptive method of shear rate estimation was effective for improving the accuracy of shear rate calculation.

  3. Basic studies on intravascular low-intensity laser therapy

    Science.gov (United States)

    Liu, Timon Cheng-Yi; Duan, Rui; Wang, Shuang-Xi; Liu, Jiang; Cui, Li-Ping; Jin, Hua; Liu, Song-Hao

    2006-09-01

    Intravascular low intensity laser therapy (ILILT) was originally put forward in USA in 1982, but popularized in Russia in 1980s and in China in 1990s, respectively. A randomized placebo-controlled study has shown ILILT clinical efficacy in patients suffering from rheumatoid arthritis. As Chinese therapeutic applications of ILILT were the most widely in the world, its basic research, such as intracellular signal transduction research, blood research in vitro, animal blood research in vivo, human blood research in vivo and traditional Chinese medicine research, was also very progressive in China. Its basic studies will be reviewed in terms of the biological information model of photobiomodulation in this paper. ILILT might work in view of its basic studies, but the further randomized placebo-controlled trial and the further safety research should be done.

  4. Design and implementation of an intravascular brachytherapy installation in cardiology

    International Nuclear Information System (INIS)

    Intravascular Brachytherapy (IVB) is a very promising technique for reducing restenosis rates. However, neither the exact absolute dose needed nor the optimal spatial and temporal distribution of dose inside the vessel wall for a successful treatment, nor the physical dosimetry of the various radioactive sources and devices for dose delivery, are well known. In this paper, an overview will be given of the design strategy, the dosimetric and radiation protection-related problems that we have met during the implementation of this technique at San Carlos hospital, adopted or foreseen solutions, and future research fields that we intend to carry out in order to reduce uncertainties and to achieve a deeper knowledge of the parameters that have an influence on the treatment. (author)

  5. Acute renal failure and intravascular hemolysis following henna ingestion.

    Science.gov (United States)

    Qurashi, Hala E A; Qumqumji, Abbas A A; Zacharia, Yasir

    2013-05-01

    The powder of henna plant (Lawsonia inermis Linn.) is extensively used as a decorative skin paint for nail coloring and as a hair dye. Most reports of henna toxicity have been attributed to adding a synthetic dye para-phenylenediamine (PPD). PPD is marketed as black henna added to natural henna to accentuate the dark color and shorten the application time. PPD toxicity is well known and extensively reported in medical literature. We report a case of a young Saudi male who presented with characteristic features of acute renal failure and intravascular hemolysis following ingestion of henna mixture. Management of PPD poisoning is only supportive and helpful only if instituted early. Diagnosis requires a high degree of clinical suspicion, as the clinical features are quite distinctive. PMID:23640630

  6. Retinal and choroidal intravascular spectral-domain optical coherence tomography

    DEFF Research Database (Denmark)

    Willerslev, Anne; Li, Xiao Qiang; Cordtz, Peter; Munch, Inger C; Larsen, Michael

    2014-01-01

    Purpose:  To examine retinal and choroidal blood vessels using spectral-domain optical coherence tomography (SD-OCT). Methods:  Retrospective case series. Results:  Scans through retinal blood vessels in healthy subjects demonstrated vessel wall reflexes and a tri-layer profile of the blood column...... and the low flow in the retinal vessels in patients with ocular ischaemic syndrome and central retinal artery occlusion were both associated with lower reflectivity of the blood and an unstructured intravascular SD-OCT profile. Discussion:  This qualitative in vivo study found a characteristically...... structured SD-OCT profile of the blood column in retinal vessels with normal blood flow. Both structure and total reflectivity faded when blood flow was lower or higher than normal or at oblique angles to the line of sight. In conclusion, SD-OCT scans of the vessels in the posterior pole of the eye may...

  7. Advanced Congestive Heart Failure Associated With Disseminated Intravascular Coagulopathy.

    Science.gov (United States)

    Sarcon, Annahita; Liu, Xiaoli; Ton, David; Haywood, James; Hitchcock, Todd

    2015-01-01

    Background. Disseminated intravascular coagulopathy (DIC) is a complication of an underlying disease and not a primary illness. It is most commonly associated with sepsis, trauma, obstetrical complications, and malignancies. There are very few cases in the literature illustrating the association between DIC and congestive heart failure. Findings. In this report, we present a case of severe congestive heart failure, leading to biventricular thrombi and subsequently DIC. Conclusion. We suggest that the association between congestive heart failure and DIC is an underrecognized one. Congestive heart failure continues to remain a major cause of morbidity and mortality despite advances in medical therapies. Thus far, the precise role of coagulation factors in congestive heart failure is unknown. Further investigations are needed to elucidate the pathophysiology of congestive heart failure and coagulation factors. PMID:26788528

  8. Acute renal failure and intravascular hemolysis following henna ingestion

    Directory of Open Access Journals (Sweden)

    Hala E. A. Qurashi

    2013-01-01

    Full Text Available The powder of henna plant (Lawsonia inermis Linn. is extensively used as a decorative skin paint for nail coloring and as a hair dye. Most reports of henna toxicity have been attributed to adding a synthetic dye para-phenylenediamine (PPD. PPD is marketed as black henna added to natural henna to accentuate the dark color and shorten the application time. PPD toxicity is well known and extensively reported in medical literature. We report a case of a young Saudi male who presented with characteristic features of acute renal failure and intravascular hemolysis following ingestion of henna mixture. Management of PPD poisoning is only suppor-tive and helpful only if instituted early. Diagnosis requires a high degree of clinical suspicion, as the clinical features are quite distinctive.

  9. Processos linfoproliferativos da pele: parte 2 - linfomas cutâneos de células T e de células NK

    OpenAIRE

    Sanches Jr. José Antonio; Moricz Claudia Zavaloni M. de; Festa Neto Cyro

    2006-01-01

    Os linfomas cutâneos de células T/NK constituem um grupo de doenças linfoproliferativas extranodais atualmente classificadas e subdivididas de acordo com o comportamento clínico segundo consenso da Organização Mundial de Saúde e da Organização Européia para Pesquisa e Tratamento do Câncer. Os linfomas cutâneos de células T/NK de comportamento clínico indolente compreendem a micose fungóide clássica, a micose fungóide foliculotrópica, a reticulose pagetóide, a cútis laxa granulomatosa, o linfo...

  10. Linfoma folicular primario duodenal: Informe de un caso y revisión de la literatura Primary follicular lymphoma of the duodenum: Case report and literature review

    Directory of Open Access Journals (Sweden)

    Juan Carlos Hiromi López T

    Full Text Available Mujer de 80 años con síntomas dispépticos a quien se le realizó endoscopia de vías digestivas altas que mostró lesiones polipoides confluentes en la segunda porción del duodeno, cuyo estudio histológico indicó un linfoma no Hodgkin B folicular primario, neoplasia duodenal infrecuente de bajo grado, la cual debe diferenciarse de hiperplasia linfoide folicular reactiva y de otros linfomasPatient was an 80 year old woman with dyspepsia. An upper endoscopy showed confluent polypoid lesions in the second portion of the duodenum. A histological study showed a follicular B-cell lymphoma. This is a rare low grade neoplasm of duodenum which must be differentiated from follicular reactive hyperplasia and other lymphomas

  11. A Case of Disseminated Intravascular Coagulation after Thoracic Endovascular Aortic Repair

    Science.gov (United States)

    2015-01-01

    I report a hemorrhagic complication due to disseminated intravascular coagulation after thoracic endovascular aortic repair for a dissecting aortic aneurysm. A 74-year-old man underwent thoracic endovascular aortic repair and carotid-carotid artery bypass to close the primary entry site of the dissecting aortic aneurysm. Postoperatively, he developed a gradually expanding cervical hematoma. Laboratory data showed disseminated intravascular coagulation. He could not extubated until postoperative day 6 because of the risk of airway obstruction. He was treated with transfusion to replenish the coagulation factor. Disseminated intravascular coagulation may occur secondary to thrombus formation in the false lumen after thoracic endovascular aortic repair. PMID:26730263

  12. Robust intravascular optical coherence elastography driven by acoustic radiation pressure

    Science.gov (United States)

    van Soest, Gijs; Bouchard, Richard R.; Mastik, Frits; de Jong, Nico; van der Steen, Anton F. W.

    2007-07-01

    High strain spots in the vessel wall indicate the presence of vulnerable plaques. The majority of acute cardiovascular events are preceded by rupture of such a plaque in a coronary artery. Intracoronary optical coherence tomography (OCT) can be extended, in principle, to an elastography technique, mapping the strain in the vascular wall. However, the susceptibility of OCT to frame-to-frame decorrelation, caused by tissue and catheter motion, inhibits reliable tissue displacement tracking and has to date obstructed the development of OCT-based intravascular elastography. We introduce a new technique for intravascular optical coherence elastography, which is robust against motion artifacts. Using acoustic radiation force, we apply a pressure to deform the tissue synchronously with the line scan rate of the OCT instrument. Radial tissue displacement can be tracked based on the correlation between adjacent lines, instead of subsequent frames in conventional elastography. The viability of the method is demonstrated with a simulation study. The root mean square (rms) error of the displacement estimate is 0.55 ?m, and the rms error of the strain is 0.6%. It is shown that high-strain spots in the vessel wall, such as observed at the sites of vulnerable atherosclerotic lesions, can be detected with the technique. Experiments to realize this new elastographic method are presented. Simultaneous optical and ultrasonic pulse-echo tracking demonstrate that the material can be put in a high-frequency oscillatory motion with an amplitude of several micrometers, more than sufficient for accurate tracking with OCT. The resulting data are used to optimize the acoustic pushing sequence and geometry.

  13. Optimization of intravascular shear stress assessment in vivo.

    Science.gov (United States)

    Ai, Lisong; Yu, Hongyu; Takabe, Wakako; Paraboschi, Anna; Yu, Fei; Kim, E S; Li, Rongsong; Hsiai, Tzung K

    2009-07-22

    The advent of microelectromechanical systems (MEMS) sensors has enabled real-time wall shear stress (WSS) measurements with high spatial and temporal resolution in a 3-D bifurcation model. To optimize intravascular shear stress assessment, we evaluated the feasibility of catheter/coaxial wire-based MEMS sensors in the abdominal aorta of the New Zealand white (NZW) rabbits. Theoretical and computational fluid dynamics (CFD) analyses were performed. Fluoroscope and angiogram provided the geometry of aorta, and the Doppler ultrasound system provided the pulsatile flow velocity for the boundary conditions. The physical parameters governing the shear stress assessment in NZW rabbits included (1) the position and distance from which the MEMS sensors were mounted to the terminal end of coaxial wire or the entrance length, (L(e)), (2) diameter ratios of aorta to the coaxial wire (D(aorta) /D(coaxial wire)=1.5-9.5), and (3) the range of Reynolds numbers (116-1550). At an aortic diameter of 2.4mm and a maximum Reynolds number of 212 (a mean Reynolds number of 64.2), the time-averaged shear stress (tau(ave)) was computed to be 10.06 dyn cm(-2) with a systolic peak at 33.18 dyn cm(-2). In the presence of a coaxial wire (D(aorta)/D(coaxial wire)=6 and L(e)=1.18 cm), the tau(ave) value increased to 15.54 dyn cm(-2) with a systolic peak at 51.25 dyn cm(-2). Real-time intravascular shear stress assessment by the MEMS sensor revealed an tau(ave) value of 11.92 dyn cm(-2) with a systolic peak at 47.04 dyn cm(-2). The difference between CFD and experimental tau(ave) was 18.5%. These findings provided important insights into packaging the MEMS sensors to optimize in vivo shear stress assessment. PMID:19457490

  14. Las marcas en el Tratado de Libre Comercio de América del Norte

    Directory of Open Access Journals (Sweden)

    Roberto Rosas Rodríguez

    2003-01-01

    Full Text Available Se trata de un ensayo que analiza la regulación de las marcas en el Tratado de Libre Comercio de América del Norte (TLCAN y su influencia en la legislación mexicana. En la primera parte, el autor explica de forma general el contenido del Tratado de Libre Comercio de América del Norte, para después referirse a las disposiciones del capítulo XVII en materia de propiedad industrial. Asimismo, explica la protección que este tratado contempla para las marcas. Posteriormente, expone la regulación de las marcas en México mediante leyes y tratados internacionales. Por último, realiza un estudio comparativo entre la Ley de Marcas española de 2001, el TLCAN y la Ley de Propiedad Industrial mexicana.

  15. Leishmaniosis laríngea recidivante: un caso inusual en un paciente inmunocompetente tratado con corticoides / Recidivant laryngeal leishmaniosis: an unusual case in an immunocompetent patient treated with corticosteroids

    Scientific Electronic Library Online (English)

    R., Casero; L., Laconte; L., Fraenza; N., Iglesias; C., Quinteros Greco; ML., Villablanca.

    2010-06-01

    Full Text Available La leishmaniosis es una parasitosis de evolución crónica; en Argentina, sus agentes etiológicos principales pertenecen al complejo Leishmania (Viannia) braziliensis, habitualmente asociado a lesiones cutáneas y mucocutáneas. Informamos en este trabajo un caso de leishmaniosis laríngea en un hombre d [...] e 29 años procedente de Jujuy, quien a raíz de múltiples subdiagnósticos portaba esta parasitosis desde hacía 20 años. En el año 2008 este paciente consulta por disfonía crónica y trastornos en las vías aéreas superiores, refiere que fue sometido a terapias con tuberculostáticos, antifúngicos y corticoides desde 2002. Diferentes biopsias y fibroscopías revelaron los siguientes diagnósticos: laringitis granulomatosa inespecífica, laringitis compatible con tuberculosis, laringitis compatible con histoplasmosis, linfoma Natural Killer extraganglionar a células pequeñas. Finalmente, estudios realizados en nuestro hospital demostraron la presencia de una laringe granulomatosa en toda su extensión, amastigotes intra y extracelulares de Leishmania spp., ausencia de formas compatibles con Micobacterias e Histoplasma, y laringitis crónica vinculable a Leishmania spp. El paciente realizó tratamiento con antimoniato de N-metil-glucamina y demostró una muy buena evolución clínica tras ser examinado 2 meses después. Si bien la leishmaniosis laríngea como lesión única no es la presentación prevalente de esta zoonosis, su estudio amerita especial atención en pacientes tratados con corticoides, pues esto evitará un diagnóstico tardío y las mayores consecuencias asociadas a la morbimortalidad propia de esta parasitosis. Abstract in english Leishmaniosis is a chronic parasitic disease, which in Argentina is mainly caused by protozoa belonging to the Leishmania (Viannia) braziliensis complex, leading to cutaneous and mucosal pathologies. We report a rare case of laryngeal leishmaniosis in a 29 year-old man from Jujuy province, Argentina [...] , who had been misdiagnosed with other pathologies, carrying this infectious disease for about 20 years. During 2008, the patient was admitted with complaints of progressive hoarseness of the voice and dyspnea. He also reported having received tuberculostatics, antifungal and corticosteroids treatments since 2002. Different biopsies and direct laryngoscopic exams revealed inespecific granulomatous larynx, TBC-related laryngitis, laryngitis related to Histoplasma infection, extra-nodal Natural Killer-cell lymphoma. Finally, the patient was evaluated at the University Hospital and the final diagnosis was: granulomatous larynx, intra and extra-cytoplasmic Leishmania spp amastigotes, negative for TBC and Histoplasma cultures, and chronic laryngitis related to Leishmania infection, according to the laryngeal endoscopy, microbiological and histopathological exams, respectively. The patient received pentavalent antimonial treatment and his condition improved after 2 months of follow-up. Primary laryngeal leishmaniosis is rare and this localization does not belong to the most prevalent mucosal leishmaniosis. However, this parasitic disease warrants special concern, especially in patients who received prolonged corticosteroid treatments, in order to avoid a misdiagnosis of this disease.

  16. Púrpura trombocitopênica idiopática e linfoma não-Hodgkin de células T na infância Idiopathic thrombocytopenic purpura and T-cell non-Hodgkin's lymphoma in childhood

    Directory of Open Access Journals (Sweden)

    Alessandra C. Borges

    2006-03-01

    Full Text Available Os linfomas representam 10% de todos os tumores malignos da infância e, destes, os linfomas não-Hodgkin são os mais freqüentes. Crianças com doenças auto-imunes apresentam maior probabilidade de desenvolver doenças linfoproliferativas, podendo ocorrer antes, durante ou após o aparecimento da neoplasia. A associação de púrpura trombocitopênica idiopática e linfomas é infreqüente (3%, principalmente na faixa etária pediátrica. Duas teorias tentam explicar a origem desta associação. Na primeira, a trombocitopenia seria decorrente da produção de auto-anticorpos antiplaquetas pelo clone tumoral. Na segunda, a PTI seria resultado de um estímulo antigênico persistente, secundário a uma desordem na proliferação linfóide. O objetivo do presente trabalho foi relatar a associação infreqüente na infância entre púrpura trombo-citopênica idiopática e linfoma não-Hodgkin de células T.Lymphomas represent 10% of all malignant tumors in childhood and from these non-Hodgkin's lymphomas are the most frequent. Children who have autoimmune diseases have a higher probability of developing lymphoproliferative diseases, which can happen before, during or after the appearance of the neoplasia. The association between idiopathic thrombocytopenic purpura and lymphomas is not common (3% especially in children. Two theories try to explain the origin of this association. In the first one, the thrombocytopenia would be a result of an autoantibody anti-blood platelet production by the tumoral clone. In the second one, the idiopathic thrombocytopenic purpura would be a result of a persistent antigenic stimulus subordinate to a disorder in the lymphoid proliferation. The aim of this work is to report the unusual association between idiopathic thrombocytopenic purpura and T-cell non-Hodgkin's lymphoma in childhood.

  17. Linfoma de células da zona do manto em anexos oculares: relato de caso Mantle-cell lymphoma of the ocular adnexa: a case report

    Directory of Open Access Journals (Sweden)

    Anna Paula Lemos de Albuquerque

    2006-06-01

    Full Text Available Os tumores linfóides dos anexos oculares são neoplasias de crescimento lento que acometem principalmente idosos. O objetivo deste trabalho é relatar um caso de linfoma não-Hodgkin de células da zona do manto, um subtipo raro de linfoma de células B nos anexos oculares. RELATO DO CASO: Paciente masculino de 62 anos com tumoração em pálpebras superiores, região maxilar e cavidade oral, tendo o diagnóstico inicial de doença de Mikulics, evoluiu com acentuado aumento das lesões, apesar da terapêutica imunossupressora. Biopsias da pálpebra superior esquerda e medula óssea revelaram linfoma não-Hodgkin de células B da zona do manto. Apesar da disseminação (estadiamento grau IV, quimioterapia e transplante de medula óssea conduziram à remissão da doença. COMENTÁRIOS CONCLUSIVOS: Apesar da disponibilidade de avançados métodos diagnósticos complementares como a imunofenotipagem e a análise genética molecular, o linfoma representa, para clínicos e patologistas, um desafio quanto ao diagnóstico e ao prognóstico.Ocular adnexal lymphoid tumors are slow-growing neoplasms that affect predominantly the elderly. The purpose of this study is to report a non-Hodgkin lymphoma from mantle zone cells, a rare ocular annexal B-cell lymphoma subtype. CASE REPORT: A 62-year-old male patient with superior eyelid, maxillary and oral tumours, had an initial diagnosis of Mikulics disease, developed lesion enlargement, despite immunosuppressant therapy. Left superior eyelid and bone marrow biopsy revealed non-Hodgkin lymphoma the mantle zone. In spite of dissemination (stage IV, chemotherapy and bone marrow transplant led to disease remission. CONCLUSIVE COMMENTARIES: Despite the availability of advanced complementary diagnostic methods, like immunophenotyping and molecular genetic analysis, lymphoma represents, for physicians and pathologists, a challenge regarding diagnosis and prognosis.

  18. Insuficiência renal aguda como manifestação inicial de linfoma de Burkitt renal Acute renal failure as first clinical presentation of Burkitt’s renal lymphoma

    Directory of Open Access Journals (Sweden)

    José Gastão Rocha de Carvalho

    2006-06-01

    Full Text Available Relatamos o caso de um jovem de 14 anos que procurou atendimento médico por edema e hipertensão, sendo insuficiência renal aguda secundária a linfoma de Burkitt renal diagnosticada após avaliação laboratorial, de imagem e biópsia de massa tumoral renal.This case report is from a 14-year-old boy who had edema and hypertension due to a primary renal Burkitt's lymphoma, diagnosed through laboratory and image evaluation and kidney tumor biopsy.

  19. Insuficiência renal aguda como manifestação inicial de linfoma de Burkitt renal Acute renal failure as first clinical presentation of Burkitt’s renal lymphoma

    OpenAIRE

    José Gastão Rocha Carvalho; Jean Rodrigo Tafarel; Wilson Beleski de Carvalho; Ana Paula Azambuja; Elicéia Soraia Zenaro; Rodrigo Bendlin

    2006-01-01

    Relatamos o caso de um jovem de 14 anos que procurou atendimento médico por edema e hipertensão, sendo insuficiência renal aguda secundária a linfoma de Burkitt renal diagnosticada após avaliação laboratorial, de imagem e biópsia de massa tumoral renal.This case report is from a 14-year-old boy who had edema and hypertension due to a primary renal Burkitt's lymphoma, diagnosed through laboratory and image evaluation and kidney tumor biopsy.

  20. Search of intravascular hemolysis in patients with the cutaneous form of loxoscelism Pesquisa de hemólise intravascular na forma cutânea de loxoscelismo

    Directory of Open Access Journals (Sweden)

    Pasquale Morena

    1994-04-01

    Full Text Available Haptoglobin assay, a highly sensitive method to detect intravascular hemolysis was carried out in the sera of 19 patients referred to Hospital Vital Brazil with the cutaneous form of loxoscelism in order to investigate the occurrence of mild intravascular hemolysis. Data from this series did not show decreased levels haptoglobin, ruling out intravascular hemolysis in these patients with cutaneous form of loxoscelism.Dezenove pacientes que apresentaram a forma clínica cutânea do loxoscelismo foram investigados com o propósito de pesquisar hemólise intravascular sub-clínica, lançando mão da dosagem de haptoglobina, um método altamente sensível que permite detectar discreta presença de hemólise intravascular. Não foi encontrada diminuição de haptoglobina, o que descarta uma ação hemolítica do veneno da Loxosceles nestes pacientes.

  1. Adsorção de ácidos húmicos em latossolo roxo natural e tratado com oxalato de amônio

    OpenAIRE

    D. P. Dick; Gomes, J.; Bayer, C.; B. Bodmann

    2000-01-01

    A interação de substâncias húmicas com minerais no solo pode influir na dinâmica da decomposição da matéria orgânica e na sua estabilidade. A adsorção de dois ácidos húmicos em Latossolo Roxo natural (LR natural) e tratado com oxalato de amônio (LR tratado) foi efetuada, com vistas em investigar os mecanismos de adsorção e os principais grupos funcionais envolvidos, bem como relacionar a capacidade adsortiva de acordo com as características químicas e moleculares dos adsorbatos. Os ácidos húm...

  2. Linfoma testicular primario: Aportación de un nuevo caso y revisión de la literatura / Primary testicular lymphoma: Contribution of one case and literature review

    Scientific Electronic Library Online (English)

    I., Gómez García; R., Rodríguez Patrón; E., Sanz Mayayo; J.M., Rodríguez Luna; A., Palmeiro Uriach; S., Conde Someso; F.J., Burgos Revilla; D., García Ortells; A., Escudero Barrilero.

    2004-02-01

    Full Text Available El linfoma testicular primario es un tumor testicular infrecuente, suponiendo no más del 9% de los tumores testiculares en las series con mayor incidencia; a su vez el linfoma testicular como tumor hematopoyético es infrecuente, con una incidencia del 1% de los linfomas, pero debido a su histopatolo [...] gía en la mayoría de los casos de alta malignidad, les hace ser de los tumores testiculares más agresivos. La edad de aparición es por encima de los 60 años, convirtiéndose en el tumor más frecuente para este grupo de edad. La falta de series amplias, hace que no exista un protocolo establecido para el tratamiento de esta patología. Presentamos un nuevo caso, realizando revisión de la bibliografía presentando las tendencias terapéuticas actuales para este tipo de patología. Abstract in english Primary testicular lymphoma is an uncommon testicular tumour that accounts for no more than 9% of all testicular tumours in those series with higher incidence; testicular lymphoma as haematopoietic tumours are also rare accounting for just 1% of all lymphomas; but due to their highly malignant histo [...] pathology they may become highly aggressive tumours. Patient age at presentation is over 60 years old which makes it the most frequent tumour for this age group. There is no standard protocol to treat this malignancy due to lack of extensive series. We contribute one case and make a literature review discussing the current therapeutic trends for this disease.

  3. Significado prognóstico dos graus histológicos do linfoma de Hodgkin do tipo esclerose nodular Prognostic significance of histopathological grading of nodular sclerosing Hodgkin’s lymphoma

    Directory of Open Access Journals (Sweden)

    Luís Fernando Pracchia

    2005-10-01

    Full Text Available INTRODUÇÃO: A esclerose nodular (EN, do tipo histológico freqüente do linfoma de Hodgkin (LH, apresenta grande variabilidade em sua composição celular. Na década de 80, pesquisadores do British National Lymphoma Investigation (BNLI propuseram uma subclassificação histológica do LH EN. Eles identificaram dois graus histológicos - o LH EN grau I (LH EN I e o LH EN grau II (LH EN II - e demonstraram que os portadores de LH EN II apresentavam menor sobrevida em comparação aos portadores de LH EN I. Outros estudos, entretanto, não reproduziram esses achados. OBJETIVO: Avaliar o significado prognóstico da graduação histológica proposta pelo BNLI. MATERIAIS E MÉTODOS: Estudo retrospectivo que incluiu 69 casos de LH EN. Mais de 90% dos casos foram tratados com terapia combinada ou quimioterapia exclusiva, não havendo diferença no tipo de tratamento oferecido a depender do grau histológico. RESULTADOS: Trinta e cinco casos (51% foram classificados com EN I e 34 (49% como EN II. Não observamos diferenças na distribuição de outros fatores prognósticos entre os portadores dos dois graus. Remissão completa após o tratamento inicial foi obtida em 85,7% dos casos de EN I e em 82,4% dos casos de EN II (p = 0,75. A probabilidade estimada de sobrevida global em cinco anos foi de 67% para EN I e de 83,5% para EN II (p = 0,13 e a taxa de sobrevida livre de doença em cinco anos foi de 85,2% versus 87%, respectivamente (p = 0,72. CONCLUSÃO: Nesta população de pacientes uniformemente tratados a graduação histológica BNLI não esteve associada com o prognóstico do LH EN.BACKGROUND: Nodular sclerosis (NS, a frequent histological subtype of Hodgkin’s lymphoma (HL, presents great variability in its cellular composition. In the 80's, researchers of the British National Lymphoma Investigation (BNLI proposed a histological-based subclassification for NS HL. They identified two histological grades - NS HL grade I (NS HL I and NS HL grade II (NS HL II - and reported that NS II patients had a lower survival rate in comparison with NS I patients. Others studies, however, did not reproduce these findings. OBJECTIVE: Evaluate the prognostic significance of the BNLI grading system. MATERIAL AND METHOD: We retrospectively studied 69 NS HL patients. More than 90% of the included cases were treated with combined modality therapy or exclusive chemotherapy, the treatment type was not different for NS I and NS II patients. RESULTS: Thirty-five cases (51% were classified as NS I and 34 (49% as NS II. We did not observe significant differences in the distribution of other prognostic factors between the two NS grades. The complete remission rate after initial therapy was 85.7% in the NS I group and 82.4% in the NS II group (p = 0.75. The predicted 5-year overall survival rate was 67% in the NS I patients and 83.5% in the NS II patients (p = 0.13. The predicted 5-year disease free survival rate for NSI and NSII patients was 85.2% and 87%, respectively (p = 0.72. CONCLUSION: The histological BNLI grading system was not associated with the prognosis of this uniformly treated NS LH population.

  4. The use of recombinant factor VIIa in a pediatric septic shock patient with disseminated intravascular coagulation

    OpenAIRE

    Ronaldo Arkader; Eduardo Juan Troster; Albert Bousso

    2008-01-01

    This is a report on a pediatric patient with septic shock and disseminated intravascular coagulation, who developed life-threatening bleeding which was successfully treated with recombinant factor VIIa.

  5. The use of intravascular ultrasound as control procedure for the deployment of endovascular stented grafts

    DEFF Research Database (Denmark)

    Vogt, K C; Brunkwall, J; Malina, M; Ivancev, K; Lindblad, B; Risberg, B; Schroeder, T V

    1997-01-01

    OBJECTIVE: To assess whether intravascular ultrasound (IVUS), used systematically in a series of patients with abdominal aortic aneurysms (AAA), is a feasible control procedure to ensure correct transfemoral placement of endovascular stent grafts (TPEG). DESIGN: Descriptive study. MATERIALS AND M...

  6. Intravascular radiation for restenosis prevention: could it be the holy grail?

    Energy Technology Data Exchange (ETDEWEB)

    King, S.B. [Emory Univ., Atlanta, GA (United States)

    1996-08-01

    This brief editorial discusses the use of intravascular radiation in preventing restenosis after angioplasty in coronary interventions. Results in porcine coronary arteries and clinical applications are briefly reported. (UK).

  7. Intravascular radiation for restenosis prevention: could it be the holy grail?

    International Nuclear Information System (INIS)

    This brief editorial discusses the use of intravascular radiation in preventing restenosis after angioplasty in coronary interventions. Results in porcine coronary arteries and clinical applications are briefly reported. (UK)

  8. A novel method of intravascular temperature modulation to treat severe hypothermia

    OpenAIRE

    Willekes, T; Naunheim, R; Lasater, M

    2006-01-01

    Intravascular rewarming may provide an efficient and reliable method of restoring normal body core temperature in patients, while avoiding after?drop. The system provides continuous temperature monitoring and automatically adjusts warm saline delivery until the desired temperature is reached.

  9. COAGULACIÓN INTRAVASCULAR DISEMINADA SECUNDARIA A ANEURISMA AÓRTICO DIAGNOSTICADA TRAS EXTRACCIÓN DENTAL

    Directory of Open Access Journals (Sweden)

    Cuevas-Ruiz MV

    2006-04-01

    Full Text Available RESUMEN:Las manifestaciones de la coagulación intravascular diseminada (CID están determinadas por la causa subyacente; sin embargo, en los casos de CID compensada el diagnóstico se basa en las pruebas de laboratorio.Presentamos el caso de un varón de 81 años al que se diagnostico de una coagulación intravascular diseminada secundaria a un aneurisma gigante de ambas ilíacas tras una extracción dentaria. SUMMARYThe clinical presentation of disseminated intravascular coagulopathy (DIC is determined by the underlying disease. However, in patients with chronic DIC the diagnostic is based in laboratory tests.We report a case of an 81-year-old male who was diagnosed disseminated intravascular coagulopathy secondary to gigant iliac aneurysm after a dental extraction

  10. The use of recombinant factor VIIa in a pediatric septic shock patient with disseminated intravascular coagulation

    Directory of Open Access Journals (Sweden)

    Ronaldo Arkader

    2008-03-01

    Full Text Available This is a report on a pediatric patient with septic shock and disseminated intravascular coagulation, who developed life-threatening bleeding which was successfully treated with recombinant factor VIIa.

  11. Comparison of external and intravascular cooling to induce hypothermia in patients after CPR

    OpenAIRE

    Strasser, Ruth H.; Wunderlich, Carsten; Gildemeister, Ramona; Diewok, Claudia; Ziegs, Enrico; Simonis, Gregor; Flemming, Kerstin

    2006-01-01

    Objective: Hypothermia has been shown to reduce neurologic deficits in patients after cardiopulmonary resuscitation (CPR). It was not clear if intravascular cooling is superior to standard external cooling in inducing hypothermia. Goal of this study was to compare intravascular cooling with an automated cooling device with external cooling in everyday practice on a cardiac-care ICU (intensive care unit). Methods: Patients after successful CPR for unwitnessed cardiac arrest were subjected to c...

  12. Comparison of external and intravascular cooling to induce hypothermia in patients after CPR

    OpenAIRE

    Flemming, K; Simonis, G; Ziegs, E; Diewok, C; Gildemeister, R; Wunderlich, C; Strasser, RH

    2006-01-01

    Objective: Hypothermia has been shown to reduce neurologic deficits in patients after cardiopulmonary resuscitation (CPR). It was not clear if intravascular cooling is superior to standard external cooling in inducing hypothermia. Goal of this study was to compare intravascular cooling with an automated cooling device with external cooling in everyday practice on a cardiac-care ICU (intensive care unit).Methods: Patients after successful CPR for unwitnessed cardiac arrest were subjected to ...

  13. Feasibility of in vivo intravascular photoacoustic imaging using integrated ultrasound and photoacoustic imaging catheter

    OpenAIRE

    Karpiouk, Andrei B.; WANG, BO; Amirian, James; Smalling, Richard W; Emelianov, Stanislav Y.

    2012-01-01

    Pilot studies of in vivo combined intravascular ultrasound (IVUS) and intravascular photoacoustic (IVPA) imaging are reported. A recently introduced prototype of an integrated IVUS/IVPA imaging catheter consisting of a single-element ultrasound transducer and a light delivery system based on a single optical fiber was adapted and used for in vivo imaging of a coronary stent deployed in a rabbit’s thoracic aorta in the presence of luminal blood. The results suggest that in vivo IVUS/IVPA imagi...

  14. Intravascular Ultrasound Catheter to Enhance Microbubble-Based Drug Delivery via Acoustic Radiation Force

    OpenAIRE

    Joseph P. Kilroy; Alexander L. Klibanov; Wamhoff, Brian R.; Hossack, John A

    2012-01-01

    Previous research has demonstrated that acoustic radiation force enhances intravascular microbubble adhesion to blood vessels in the presence of flow for molecular-targeted ultrasound imaging and drug delivery. A prototype acoustic radiation force intravascular ultrasound (ARFIVUS) catheter was designed and fabricated to displace a microbubble contrast agent in flow representative of conditions encountered in the human carotid artery. The prototype ARFIVUS transducer was designed to match the...

  15. Elimination of Bloodstream Infections Associated with Candida albicans Biofilm in Intravascular Catheters

    OpenAIRE

    Freshta Akbari; Birthe Veno Kjellerup

    2015-01-01

    Intravascular catheters are among the most commonly inserted medical devices and they are known to cause a large number of catheter related bloodstream infections (BSIs). Biofilms are associated with many chronic infections due to the aggregation of microorganisms. One of these organisms is the fungus Candida albicans. It has shown to be one of the leading causes of catheter-related BSIs. The presence of biofilm on intravascular catheters provide increased tolerance against antimicrobial trea...

  16. Linfoma de Hodgkin na infância e adolescência: 15 anos de experiência com o protocolo DH-II-90 / Hodgkin's lymphoma in children and adolescents: 15 years of experience with the DH-II-90 protocol

    Scientific Electronic Library Online (English)

    Luciana N. S., Souza; Paulo T., Maluf Junior; Maria Tereza A., Almeida; Eduardo, Weltman; Ana Lucia, Cornacchioni; Roberto Augusto P., Teixeira; Vicente, Odone Filho; Lilian Maria, Cristofani.

    Full Text Available O desafio do tratamento do linfoma de Hodgkin na infância reside na redução da toxicidade aguda e tardia sem afetar os bons resultados terapêuticos. Crianças e adolescentes portadores de linfoma de Hodgkin recém-diagnosticado foram tratados com o protocolo institucional DH-II-90. Os objetivo deste t [...] rabalho foram: 1)avaliar as taxas de sobrevida global (SG) e livre de eventos (SLE) do protocolo DH-II-90 aplicado a portadores de LH; 2)avaliar as taxas de SG e SLE conforme estádio, idade, tumor "bulky", massa mediastinal, sintomas B, dose de radioterapia e 3)descrever os efeitos tardios. Sessenta e oito pacientes portadores de LH recém-diagnosticado, com idade entre 0 e 21 anos (idade mediana 9 anos, 20F:48M), foram tratados com quimioterapia (baixo risco:ABVD; alto risco:ABVD+MOP/COP) e radioterapia. O estadiamento foi distribuído desta forma: nove (13,2%) estádio I A; 29 (42,6%) II A; cinco (7,4%) II B; nove (13,2%) III A; dez (14,7%) III B; dois (2,9%) IV A e quatro (5,9%) IV B. A SG em dez anos foi de 96,1% ± 3,8 para o grupo de baixo risco e 93,3% ± 4,5 para o de alto risco (p:0,402). A SLE foi de 88,9% ± 5,2 em dez anos para o de alto risco e 86,5% ± 6,3 para o de baixo risco (p: 0,969). A presença de massa mediastinal e doses de radioterapia maiores que 2100 cGy (p= 0,020 e p= 0,014, respectivamente) apresentam impacto negativo na SLE e a doença estádio I tem impacto positivo na SLE. Disfunção e carcinoma de tireoide são os efeitos tardios mais frequentes neste grupo de doentes. O protocolo DH-II-90 obteve resultados terapêuticos favoráveis, porém as taxas de complicações tardias, embora aceitáveis, demandam revisão do programa terapêutico. Abstract in english The challenge of new protocols for Hodgkin's lymphoma (HL) treatment is to decrease the toxicity without impairing the results. The DH-II-90 protocol was designed to treat children and adolescents with HL. The objectives of this work were: 1) to assess the overall and event free survival of patients [...] with newly diagnosed HL treated with the DH-II-90 protocol, 2) to assess the overall and event free survival by stage, age, presence of bulky disease, mediastinal mass, B symptoms, dose and type of radiotherapy, and 3) to describe late effects, data collected from the patients' charts. Sixty-eight patients with HL, from 0 to 21 years of age (median age 9 yr, 20F:48M) were treated with ABVD and involved-field radiotherapy for low-risk patients, and ABVD plus MOP or COP and extended field radiotherapy for high-risk patients. Stage distribution was: nine (13.2%) stage I A; 29 (42.6%) II A; five (7.4%) II B; nine (13.2%) III A; ten (14.7%) III B; two (2.9%) IV A and four (5.9%) IV B. The 10-year overall survival was 96.1% ± 3.8% for the low-risk group and 93.3% ± 4.5% for the high-risk group (p= 0.402). The 10-year event free survival was 88.9% ± 5.2% for high-risk and 86.5% ± 6.3% for low-risk patients (p= 0.969). The presence of mediastinal mass and more than 2100 cGy radiation doses had negative impact on event free survival (p= 0.020 and p= 0.014, respectively).Thyroid gland dysfunction was frequently observed and there were two cases of thyroid carcinoma. The DH-II-90 protocol is effective, but, due to the late effects presented by this group of patients, further modifications of the therapy schedule are required.

  17. Evolutive behavior towards cardiomyopathy of treated (nifurtimox or benznidazole and untreated chronic chagasic patients Evolução à miocardiopatia dos infectados chagásicos crônicos tratados (nifurtimox ou benzonidazol e não tratados

    Directory of Open Access Journals (Sweden)

    Diana FABBRO de SUASNÁBAR

    2000-04-01

    Full Text Available The aim of this work was to compare the evolution of chronic chagasic untreated patients (UTPs with that of benznidazole or nifurtimox-treated patients (TPs. A longitudinal study from a low endemic area (Santa Fe city, Argentina was performed during an average period of 14 years. Serological and parasitological analyses with clinical exams, ECG and X-chest ray were carried out. At the onset, 19/198 infected patients showed chagasic cardiomyopathy (CrChM while 179 were asymptomatic. In this latter group the frequency of CrChM during the follow-up was lower in TPs compared with UTPs (3.2% vs 7%. Within the CrChM group, 2/5 TPs showed aggravated myopathy whereas this happened in 9/14 UTPs. Comparing the clinical evolution of all patients, 5.9% of TPs and 13% of UTPs had unfavourable evolution, but the difference is not statistically relevant. Serological titers were assessed by IIF. Titers equal to or lower than 1/64 were obtained in 86% of the TPs, but only in 38% of UTPs. The differences were statistically significant (geometric mean: 49.36 vs. 98.2. Antiparasitic assessment of the drugs (xenodiagnosis proved to be effective. The low sensitivity in chronic chagasic patients must be born in mind. Despite treated patients showed a better clinical evolution and lower antibody levels than untreated ones, it is necessary to carry on doing research in order to improve therapeutic guidelines, according to the risk/benefit equation and based on scientific and ethical principles.Para comparar a evolução dos infectados chagásicos crônicos não tratados (UTPs e tratados (TPs com nifurtimox ou benznidazol, fez-se um estudo longitudinal numa área de baixa endemicidade (cidade de Santa Fe, Argentina, com média de seguimento de 14 anos. Em cada controle foram feitas análises sorológicas e parasitológicas, exames clínicos, eletrocardiográficos e radiológicos. No inicio, 19/198 infectados apresentaram miocardiopatia chagásica crônica (MChCr, enquanto 179 eram assintomáticos. A frequência de MChCr no seguimento destes últimos foi 3,2% para os tratados e 7% para os não tratados. Dos pacientes com MChCr no início, 2/5 dos tratados e 9/14 dos não tratados agravaram sua miocardiopatia. Comparando a evolução clínica dos infectados, 5,9% dos tratados e 13% dos não tratados tiveram evolução desfavorável, mas esta diferença não é estatisticamente significativa. Na avaliação sorológica por IFI, 86% dos TPs e só 38% dos UTPs apresentaram títulos menores ou iguais a 1/64. As diferenças são estatisticamente significativas (média geométrica: 49,36 vs 98,2. Os xenodiagnósticos seriados realizados, demonstraram efetividade das drogas (considerar a baixa sensibilidade deste método na etapa crônica. Os pacientes tratados mostraram melhor evolução clínica e mais baixos níveis de anticorpos do que os não tratados. É preciso continuar as investigações para estabelecer pautas terapêuticas mais claras sobre a relação risco-benefício, sustentadas nos princípios científicos e éticos.

  18. MRI phenotypes of localized intravascular coagulopathy in venous malformations

    Energy Technology Data Exchange (ETDEWEB)

    Koo, Kevin S.H. [Boston Children' s Hospital, Department of Radiology, Boston, MA (United States); Dowd, Christopher F.; Hess, Christopher P. [University of California, San Francisco, Department of Radiology and Biomedical Imaging, San Francisco, CA (United States); Mathes, Erin F.; Frieden, Ilona J. [University of California, San Francisco, Department of Dermatology, San Francisco, CA (United States); Rosbe, Kristina W. [University of California, San Francisco, Department of Otolaryngology, San Francisco, CA (United States); Hoffman, William Y. [University of California, San Francisco, Department of Surgery, San Francisco, CA (United States)

    2015-10-15

    The incidence of localized intravascular coagulopathy (LIC) in venous malformations varies with lesion size and location, as well as the presence of palpable phleboliths. The development of LIC can cause pain and hemorrhage and can progress to disseminated intravascular coagulopathy (DIC) and thromboembolic disease resulting in death in some cases. Early recognition of LIC can relieve symptoms and prevent progression to life-threatening complications. The aim of this work was to identify MRI features of venous malformation associated with LIC. We hypothesized that venous malformations with larger capacitance, slower flow and less physiological compression (greater stasis) were more likely to be associated with LIC. In this HIPAA-compliant and IRB-approved study, we retrospectively reviewed clinical records and MRI for consecutive patients undergoing evaluation of venous malformations at our multidisciplinary Birthmarks and Vascular Anomalies Center between 2003 and 2013. Inclusion required consensus diagnosis of venous malformation and availability of laboratory data and MRI; patients on anticoagulation or those previously undergoing surgical or endovascular treatment were excluded. LIC was diagnosed when D-dimer exceeded 1,000 ng/mL and/or fibrinogen was less than 200 mg/dL. Two board-certified radiologists assessed the following MRI features for each lesion: morphology (spongiform vs. phlebectatic), presence of phleboliths, size, location (truncal vs. extremity), and tissue type(s) involved (subcutis, muscle, bone and viscera). Univariate logistic regression analyses were used to test associations between LIC and MRI findings, and stepwise regression was applied to assess the significance of the individual imaging predictors. Seventy patients, 37 with LIC, met inclusion criteria during the 10-year study period (age: 14.5 +/- 13.6 years [mean +/- standard deviation]; 30 male, 40 female). Both elevated D-dimer and low fibrinogen were associated with the presence of phleboliths, larger lesion sizes and visceral involvement on MRI (all P < 0.05). In stepwise regressions, lesion size (P < 0.001), the presence of phleboliths (P = 0.005) and lesion morphology (P = 0.006) were all significant predictors of LIC. LIC is associated with larger lesion size, visualized phleboliths, truncal location and spongiform morphology on MRI in venous malformations, suggesting that lesions with larger capacitance, slower flow and less physiological compression are more likely to be associated with coagulopathy. (orig.)

  19. MRI phenotypes of localized intravascular coagulopathy in venous malformations

    International Nuclear Information System (INIS)

    The incidence of localized intravascular coagulopathy (LIC) in venous malformations varies with lesion size and location, as well as the presence of palpable phleboliths. The development of LIC can cause pain and hemorrhage and can progress to disseminated intravascular coagulopathy (DIC) and thromboembolic disease resulting in death in some cases. Early recognition of LIC can relieve symptoms and prevent progression to life-threatening complications. The aim of this work was to identify MRI features of venous malformation associated with LIC. We hypothesized that venous malformations with larger capacitance, slower flow and less physiological compression (greater stasis) were more likely to be associated with LIC. In this HIPAA-compliant and IRB-approved study, we retrospectively reviewed clinical records and MRI for consecutive patients undergoing evaluation of venous malformations at our multidisciplinary Birthmarks and Vascular Anomalies Center between 2003 and 2013. Inclusion required consensus diagnosis of venous malformation and availability of laboratory data and MRI; patients on anticoagulation or those previously undergoing surgical or endovascular treatment were excluded. LIC was diagnosed when D-dimer exceeded 1,000 ng/mL and/or fibrinogen was less than 200 mg/dL. Two board-certified radiologists assessed the following MRI features for each lesion: morphology (spongiform vs. phlebectatic), presence of phleboliths, size, location (truncal vs. extremity), and tissue type(s) involved (subcutis, muscle, bone and viscera). Univariate logistic regression analyses were used to test associations between LIC and MRI findings, and stepwise regression was applied to assess the significance of the individual imaging predictors. Seventy patients, 37 with LIC, met inclusion criteria during the 10-year study period (age: 14.5 +/- 13.6 years [mean +/- standard deviation]; 30 male, 40 female). Both elevated D-dimer and low fibrinogen were associated with the presence of phleboliths, larger lesion sizes and visceral involvement on MRI (all P < 0.05). In stepwise regressions, lesion size (P < 0.001), the presence of phleboliths (P = 0.005) and lesion morphology (P = 0.006) were all significant predictors of LIC. LIC is associated with larger lesion size, visualized phleboliths, truncal location and spongiform morphology on MRI in venous malformations, suggesting that lesions with larger capacitance, slower flow and less physiological compression are more likely to be associated with coagulopathy. (orig.)

  20. Linfoma ileal primário como uma causa de intussuscepção ileocecal recorrente Primary ileal lymphoma as a cause of recurrent ileocecal

    Directory of Open Access Journals (Sweden)

    Fábio César Miranda Torricelli

    2008-06-01

    Full Text Available INTRODUÇÃO: A intussuscepção ocorre quando um segmento proximal do intestino invagina para dentro do lúmen do segmento distal adjacente. Esta patologia é relativamente comum em crianças, sendo geralmente idiopática, diferentemente do que é evidenciado em adolescentes e adultos, os quais apresentam uma causa orgânica comprovada na maioria dos casos. O linfoma intestinal como etiologia desta patologia é extremamente raro. RELATO DE CASO: Um paciente de 16 anos, masculino, referindo dor abdominal em quadrante inferior direito há 36 horas associada a vômitos e fezes com sangue vivo compareceu em nosso serviço. O exame físico se apresentava dentro da normalidade exceto por uma massa palpável no quadrante inferior direito. A ultra-sonografia abdominal revelou intussuscepção ileocecal. A colonoscopia demonstrou uma massa protuberante proveniente do orifício da válvula ileocecal que foi reduzida, tendo o paciente um alívio completo dos sintomas. Três semanas após, o paciente retornou ao nosso hospital com recorrência dos sintomas. Uma laparotomia exploradora foi realizada evidenciando uma massa polipóide no íleo terminal com intussuscepção para dentro do ceco. Uma colectomia direita ampliada foi realizada. Após exame patológico da peça e estadiamento tumoral, um linfoma de Burkitt primário foi diagnosticado. A recuperação pós-operatória não apresentou intercorrências e o paciente foi encaminhado para quimioterapia adjuvante.INTRODUCTION: Intussusception occurs when a proximal segment of bowel telescopes into the lumen of the adjacent distal segment. It is common in children being usually idiophatic, in contrast to adolescents and adults, who have a demonstrable etiology in most cases. Intestinal lymphoma is an unusual cause of intussusception in adolescents and adults. CASE REPORT: A 16 year-old male presented with right lower quadrant abdominal pain lasting for 36 hours, with vomiting and bloody stool. Physical examination was unremarkable except for a palpable mass at the right lower quadrant. Abdominal sonography revealed ileocecal intussusception. Colonoscopy showed a protruding mass from the orifice of ileocecal valve which was reduced, and the patient had full withdrawal of symptoms. Three weeks later, the patient came back to our hospital with recurrent symptoms. Laparotomy was performed and a polypoid mass was noted at the terminal ileum with intussusception into the cecum. A right hemicolectomy was performed. After pathologic examination and tumor staging, a primary Burkitt lymphoma of the distal ileum was diagnosed. Postoperative convalescence was uneventful and the patient was referred to adjuvant chemotherapy.

  1. Heartbeat OCT: in vivo intravascular megahertz-optical coherence tomography.

    Science.gov (United States)

    Wang, Tianshi; Pfeiffer, Tom; Regar, Evelyn; Wieser, Wolfgang; van Beusekom, Heleen; Lancee, Charles T; Springeling, Geert; Krabbendam, Ilona; van der Steen, Antonius F W; Huber, Robert; van Soest, Gijs

    2015-12-01

    Cardiac motion artifacts, non-uniform rotational distortion and undersampling affect the image quality and the diagnostic impact of intravascular optical coherence tomography (IV-OCT). In this study we demonstrate how these limitations of IV-OCT can be addressed by using an imaging system that we called "Heartbeat OCT", combining a fast Fourier Domain Mode Locked laser, fast pullback, and a micromotor actuated catheter, designed to examine a coronary vessel in less than one cardiac cycle. We acquired in vivo data sets of two coronary arteries in a porcine heart with both Heartbeat OCT, working at 2.88 MHz A-line rate, 4000 frames/s and 100 mm/s pullback speed, and with a commercial system. The in vivo results show that Heartbeat OCT provides faithfully rendered, motion-artifact free, fully sampled vessel wall architecture, unlike the conventional IV-OCT data. We present the Heartbeat OCT system in full technical detail and discuss the steps needed for clinical translation of the technology. PMID:26713214

  2. Meta-analysis on intravascular low energy laser therapy

    Science.gov (United States)

    Zhao, Shu-Dong; Liu, Timon Cheng-Yi; Wang, Yan-Fang; Liu, Song-Hao

    2008-12-01

    Intravascular low energy laser therapy (ILELT) was put forward for cardiocirculatory diseases in USA in 1982, was popular in Russia in 1980s, and then in China in 1990s. The therapeutic effects of ILELT and drugs in comparison with drugs only on Chinese patients and their blood parameters were analyzed with meta-analyses and reported as (OR, 95%CI) for patient improvement and (WMD, 95% CI) for blood parameter improvement, where 95%CI, OR and WMD denoted 95% confidence intervals, odds ratio and weighted mean difference, respectively. It was found that the patients of cerebral infarction (2.39, 2.09~2.74) and cerebrovascular diseases (2.97, 1.69~2.53) were cured, respectively, (P cerebral infarction, cerebrovascular diseases and diabetes were significant (3.13, 2.79~3.51), (4.92, 3.39~7.14) , and (3.80, 2.79~5.18), and mild (3.66, 3.15~4.24), (4.95, 2.77~8.84), and (7.11, 4.54~11.13), respectively, (P cerebral infarction, cerebrovascular diseases and diabetes might be improved with ILELT, which might be mediated by blood parameter improvement.

  3. Primary intravascular large B-cell lymphoma of pituitary

    Directory of Open Access Journals (Sweden)

    K R Anila

    2012-01-01

    Full Text Available A 68-year-old retired nurse, who was a known hypertensive on medication, presented with prolonged fever of 2-month duration without any clinical evidence of infection. On examination she had altered mental status. She also had other nonspecific complaints such as sleep disturbances, loss of weight, etc. On investigation, she was found to have anemia, thrombocytopenia, raised erythrocyte sedimentation rate (ESR, C-reactive protein (CRP, and lactate dehydrogenase (LDH values. She also had electrolyte imbalance. Radiological evaluation of brain showed mass lesion in the sella turcica, suggestive of pituitary adenoma. Biochemical evaluation showed hypopituitarism. Trans-sphenoidal biopsy was done. Based on histopathological and immunohistochemical findings a diagnosis of intravascular large B-cell lymphoma (IVLBCL of pituitary was made. Our patient′s condition deteriorated rapidly and she succumbed to her illness before therapy could be initiated. We are reporting this case because of the rare subtype of large B-cell lymphoma presenting at an extremely unusual primary site.

  4. Microbial diversity on intravascular catheters from paediatric patients.

    Science.gov (United States)

    Zhang, L; Marsh, N; Long, D; Wei, M; Morrison, M; Rickard, C M

    2015-12-01

    Microorganisms play important roles in intravascular catheter (IVC)-related infections, which are the most serious complications in children with IVCs, leading to increased hospitalisation, intensive care admissions, extensive antibiotic treatment and mortality. A greater understanding of bacterial communities is needed in order to improve the management of infections. We describe here the systematic culture-independent evaluation of IVC bacteriology in IVC biofilms. Twenty-four IVC samples (six peripherally inserted central catheters, eight central venous catheters and ten arterial catheters) were collected from 24 paediatric patients aged 0 to 14 years old. Barcoded amplicon libraries produced from genes coding 16S rRNA and roll-plate culture methods were used to determine the microbial composition of these samples. From a total of 1,043,406 high-quality sequence reads, eight microbial phyla and 136 diverse microbial genera were detected, separated into 12,224 operational taxonomic units (OTUs). Three phyla (Actinobacteria, Firmicutes and Proteobacteria) predominate the microorganism on the IVC surfaces, with Firmicutes representing nearly half of the OTUs found. Among the Firmicutes, Staphylococcus (15.0 % of 16S rRNA reads), Streptococcus (9.6 %) and Bacillus (6.1 %) were the most common. Community composition did not appear to be affected by patients' age, gender, antibiotic treatment or IVC type. Differences in IVC microbiota were more likely associated with events arising from catheter dwell time, rather than the type of IVC used. PMID:26515578

  5. Effects of intravascular contrast media on blood-brain barrier

    International Nuclear Information System (INIS)

    The effects upon the rabbit blood-brain barrier after intracarotid injection of two non-ionic contrast media, iopentol (a monomer) and iodixanol (a dimer) were compared. Iothalamate and iohexol were used as reference substances. 99Tcm-DTPA, 125I-HSA and Trypsin blue were used as tracers in order to demonstrate various degrees of damage to the barrier. Injection of iothalamate led to large extravasation of 99Tcm-DTPA, 125I-HSA and Trypan blue which means severe damage of the blood-brain barrier. Injection of iopentol and iohexol resulted in some extravasation of all three tracers used, whereas injection of iodixanol only led to extravasation of the small molecule tracer 99Tcm-DTPA demonstrating minor changes of the barrier. At computed tomography of the brain with intravascular contrast medium enhancement it is safer to use iodixanol than iothalamate. Iodixanol is expected to cause even less adverse effects to the brain after intraarterial injection than iopentol and iohexol. (orig.)

  6. Disseminated intravascular coagulation in non-Hodgkin lymphoma.

    Science.gov (United States)

    Chi, SungGi; Ikezoe, Takayuki

    2015-10-01

    The present study analyzed the incidence and clinical features of disseminated intravascular coagulation (DIC) developed in association with non-Hodgkin lymphoma (NHL). Two hundred thirty-six patients with newly diagnosed NHL were admitted to our institute since Jul. 2008 to Dec. 2014. Coagulation markers were evaluated in 161 of 236 patients at the time of diagnosis. DIC was diagnosed in 18 patients (11.2 %) based on the criteria established by Ministry of Health, Labor, and Welfare of Japan. All of the 18 patients had Ann-Arbor Stage IV advanced disease, and 17 patients were in poor performance status. Liver function panels, such as bilirubin, aminotransferases, serum choline esterase, and albumin levels, were worse in patients with DIC than those without DIC, indicating impaired production of coagulation factors. Importantly, DIC exerts significantly negative impact on prognosis of NHL; median survival of both groups was 176 versus 2430 days. The difference remains significant after statistically adjusting for age, performance status, Ann-Arbor stage, international prognostic index, and liver function panels. Nine of 18 patients with DIC received anti-coagulants, which failed to improve clinical outcome. Nevertheless, early recognition and intervention to DIC state may contribute to improve prognosis of NHL. PMID:26272605

  7. [Aneurysm of the abdominal aorta and preoperative disseminated intravascular coagulation].

    Science.gov (United States)

    Chauvet, V; Bussac, J J; Jullian, H; Juhan-Vague, I; Branchereau, A

    1991-01-01

    A case of abdominal aortic aneurysm associated with preoperative signs of disseminated intravascular coagulation is reported. The 69-year-old female patient presented with spontaneously appearing petechiae and bruising. She had 0.95 g.l-1 fibrinogen, 105 G.l-1 platelets, and 100 micrograms.ml-1 fibrin and fibrinogen degradation products. Investigations revealed an 80 mm diameter aneurysm of the abdominal aorta, extending from the coeliac trunk to the iliac arteries. Heparin 7,000 IU.day-1 resulted in a biological improvement for a week only. At that time, levels of coagulation factors were: 92% factor II, 88% factor V, 100% factors VII and X, 100% antithrombin III. Surgical cure of the aneurysm was nevertheless carried out. Twenty standard units of platelets, 8 g fibrinogen, four units of fresh frozen plasma, five homologous and two autologous red cell units were transfused during the procedure. No coagulation factors were necessary during the postoperative course, which was uneventful. The management of coagulation factor infusions, before or after aortic cross-clamping, is discussed. PMID:2058833

  8. Processos linfoproliferativos da pele: parte 2 - linfomas cutâneos de células T e de células NK Processos linfoproliferativos da pele: part 2 - cutaneous T-cell and NK-cell lymphomas

    Directory of Open Access Journals (Sweden)

    José Antonio Sanches Jr

    2006-02-01

    Full Text Available Os linfomas cutâneos de células T/NK constituem um grupo de doenças linfoproliferativas extranodais atualmente classificadas e subdivididas de acordo com o comportamento clínico segundo consenso da Organização Mundial de Saúde e da Organização Européia para Pesquisa e Tratamento do Câncer. Os linfomas cutâneos de células T/NK de comportamento clínico indolente compreendem a micose fungóide clássica, a micose fungóide foliculotrópica, a reticulose pagetóide, a cútis laxa granulomatosa, o linfoma cutâneo primário de grande célula anaplásica, a papulose linfomatóide, o linfoma subcutâneo de célula T paniculite-símile e o linfoma cutâneo primário de pequena e média célula T CD4+ pleomórfica. Os linfomas cutâneos de células T/NK de comportamento agressivo incluem a síndrome de Sézary, o linfoma extranodal de célula T/NK, tipo nasal, o linfoma cutâneo primário agressivo de célula T CD8+ epidermotrópica, o linfoma cutâneo de célula T gd e o linfoma cutâneo primário de célula T periférica, não especificado. O linfoma-leucemia de células T do adulto e a neoplasia hematodémica CD4+CD56+, embora considerados linfomas sistêmicos, são aqui abordados por apresentarem-se inicialmente na pele em significativo número de pacientes. O diagnóstico desses processos é realizado pelo exame histopatológico complementado pela análise do fenótipo das células neoplásicas, imprescindível no processo classificatório. O estadiamento para a avaliação da extensão anatômica da doença considera além do envolvimento cutâneo, o estado clínico e histológico dos linfonodos e das vísceras. Avaliação hematológica é fundamental na caracterização da síndrome de Sézary. Os tratamentos preconizados incluem terapêuticas dirigidas exclusivamente à pele, modificadores da resposta biológica e quimioterapia sistêmica.The cutaneous NKT/cell lymphomas are a group of extranodal lymphoproliferative disorders currently classified and subdivided based on their clinical behavior, according to a consensus reached between the World Health Organization and the European Organization for Research and Treatment of Cancer. The cutaneous NKT/cell lymphomas of indolent clinical behavior comprise the classical mycosis fungoides, folliculotropic mycosis fungoides, pagetoid reticulosis, granulomatous slack skin, primary cutaneous anaplastic large cell lymphoma, lymphomatoid papulosis, subcutaneous panniculitis-like T-cell lymphoma and primary cutaneous CD4+ small/medium-sized pleomorphic T-cell lymphoma. The aggressive clinical behavior cutaneous NKT/cell lymphomas include Sézary syndrome, extranodal NK/T-cell lymphoma, nasal type, primary cutaneous aggressive epidermotropic CD8+T-cell lymphoma, cutaneous gamma-delta T-cell lymphoma and primary cutaneous peripheral T-cell lymphoma, unspecified. The adult T-cell leukemia lymphoma and CD4+ CD56+ hematodermic neoplasm are considered systemic lymphomas but are addressed in this article for their initial cutaneous manifestations in a significant number of patients. The diagnosis of these processes is based on histological examination complemented by phenotypic analysis of neoplastic cells, which is essential for classification. The recommended staging is based on type and extension of cutaneous involvement, clinical conditions and histological examination of lymph nodes and organs. Hematological assessment is fundamental to characterize Sézary syndrome. The recommended therapies include exclusively cutaneous treatment, biological response modifiers and systemic chemotherapy.

  9. Linfoma T subcutâneo do tipo paniculite: relato de um caso acometendo paciente pediátrico Subcutaneous panniculitic T cell lymphoma: a case report affecting a child

    Directory of Open Access Journals (Sweden)

    Lúcia de Noronha

    2001-01-01

    Full Text Available Os autores relatam um caso de linfoma T subcutâneo do tipo paniculite em uma paciente feminina de 3 anos, apresentando havia um mês múltiplos nódulos subcutâneos, indolores, disseminados no abdome, região peitoral e cervical. Ao exame histopatológico, evidenciou-se um linfoma T infiltrando tecido adiposo subcutâneo. Os linfomas T subcutâneos representam uma entidade clinicopatológica distinta, sendo raro o acometimento pediátrico.We report a case of lypotrophic lymphoma affecting a 3-year-old child with 1-month history of nontender subcutaneous nodules disseminated throughout the abdomen, chest and cervical region. Histological examination showed a T-cell lymphoma affecting the subcutaneous tissue. Subcutaneous panniculitis-like T-cell lymphoma is an unusual cutaneous T-cell lymphoma that rarely affects pediatric patients.

  10. Intravascular ultrasound assessed incomplete stent apposition and stent fracture in stent thrombosis after bare metal versus drug-eluting stent treatment the Nordic Intravascular Ultrasound Study (NIVUS)

    DEFF Research Database (Denmark)

    Kosonen, Petteri; Vikman, Saila; Jensen, Lisette Okkels; Lassen, Jens Flensted; Harnek, Jan; Olivecrona, Göran K; Erglis, Andrejs; Fossum, Eigil; Niemelä, Matti; Kervinen, Kari; Ylitalo, Antti; Pietilä, Mikko; Aaroe, Jens; Kellerth, Thomas; Saunamäki, Kari; Thayssen, Per; Hellsten, Lars; Thuesen, Leif; Niemelä, Kari

    2012-01-01

    This prospective multicenter registry used intravascular ultrasound (IVUS) in patients with definite stent thrombosis (ST) to compare rates of incomplete stent apposition (ISA), stent fracture and stent expansion in patients treated with drug-eluting (DES) versus bare metal (BMS) stents. ST is a...

  11. Differential MR Delayed Enhancement Patterns of Chronic Myocardial Infarction between Extracellular and Intravascular Contrast Media

    Science.gov (United States)

    Wang, Jian; Xiang, Bo; Lin, Hung Yu; Liu, Hongyu; Freed, Darren; Arora, Rakesh C.; Tian, Ganghong

    2015-01-01

    Objectives Because the distribution volume and mechanism of extracellular and intravascular MR contrast media differ considerably, the enhancement pattern of chronic myocardial infarction with extracellular or intravascular media might also be different. This study aims to investigate the differences in MR enhancement patterns of chronic myocardial infarction between extracellular and intravascular contrast media. Materials and Methods Twenty pigs with myocardial infarction underwent cine MRI, first pass perfusion MRI and delayed enhancement MRI with extracellular or intravascular media at four weeks after coronary occlusion. Myocardial blood flow (MBF) was determined with microsphere measurement. The infarction histopathological changes were evaluated by hematoxylin and eosin staining and Masson's trichrome method. Results Cine MRI revealed the reduced wall thickening in chronic infarction compared with normal myocardium. Moreover, significant wall thinning in chronic infarction was observed in cine MRI. Peak first-pass signal intensity didn’t significantly differ between chronic infarction and normal myocardium no matter what kinds of contrast media. At the following delayed enhancement phase, extracellular media-enhanced signal intensity was significantly higher in chronic infarction than in normal myocardium. Conversely, intravascular media-enhanced signal intensity was almost equivalent among chronic infarction and normal myocardium. At four weeks after infarction, MBF in chronic infarction approached to that in normal myocardium. Large thick-walled vessels were detected at peri-infarction zones. The cardiomyocytes were replaced by scar tissue consisting of dilated blood vessels and discrete fibers of collagen. Conclusions Chronic infarction was characterized by the significantly reduced wall thickening and the definite wall thinning. First-pass myocardial perfusion defect was not detected in chronic infarction with two media due to the significantly recovered MBF and well-developed collateral vessels. Infarction remodeling enlarged the extracellular compartment, which was available for extracellular media but not accessible to intravascular media. Extracellular media identified chronic infarction as the hyper-enhancement; nonetheless, intravascular media didn’t provide delayed enhancement. PMID:25816056

  12. Linfoma intestinal de células T e doença celíaca

    Directory of Open Access Journals (Sweden)

    Flávia Semedo

    2013-05-01

    Full Text Available O linfoma de células T associado a enteropatia (LTAE é uma neoplasia rara, com origem nos linfócitos T intestinais intraepiteliais e que está frequentemente associado a doença celíaca (DC. Os autores relatam o caso de um doente com quadro de desconforto abdominal, perda de peso acentuada, intolerância ao glúten, com anticorpos antigliadina positivos e múltiplas adenomegálias mesentéricas, ao qual foi diagnosticado DC e LTAE após ressecção cirúrgica de segmento do jejuno com cerca de 15 centímetros, envolvido por implantes tumorais. Com a descrição deste caso, salienta-se a dificuldade no diagnóstico clínico e anatomopatológico desta entidade, alicerçando o tema numa revisão da literatura.

  13. Linfoma hepático primario: causa infrecuente de lesión focal hepática

    Directory of Open Access Journals (Sweden)

    Carolina Balduzzi

    2010-01-01

    de una punción biopsia ecoguiada informa una infiltración masiva por un linfoma B difuso de células grandes. La inmunohistoquímica es CD20+ , CD45+ con CD3, CKAE1, AE3, Hepatocyte y HMB45 negativos. La citología del líquido pleural es negativa para atipía, el frotis de sangre periférica descarta una leucemia, la biopsia de médula ósea es negativa para infitración linfomatosa y el centellograma con galio y la tomografía computada corporal pelvis no revelan lesiones extrahepáticas. La paciente inicia quimioterapia con ciclofosfamida y metilprednisona, pero empeora y fallece dos semanas después de iniciado el tratamiento. Concluimos que nuestra paciente tenía una enfermedad rara con una lesión irresecable, factores de mal pronóstico y alto riesgo de recurrencia. La quimioterapia es el tratamiento de elección en estos casos.

  14. Caracterización clínico-epidemiológica de los linfomas en un período de cinco años en Villa Clara / Clinical and epidemiological characterization of lymphomas in a five year-period in Villa Clara

    Scientific Electronic Library Online (English)

    Olga Lidia, Alonso Mariño; Ana Luisa, Alonso Mariño; Jorge, Miranda Chaviano.

    2015-03-01

    Full Text Available Introducción: Los linfomas de Hodgkin y no Hodgkin son neoplasias malignas derivadas de los componentes celulares del sistema inmune, en particular, de los linfocitos y de sus precursores. Constituyen un grupo muy heterogéneo con amplias diferencias clinicobiológicas, pronósticas y terapéuticas. Obj [...] etivo: Caracterizar algunas variables clínico - epidemiológicas en los linfomas. Métodos: Se realizó un estudio descriptivo y longitudinal entre enero de 2006 y diciembre de 2010 que incluyó a todos los pacientes adultos atendidos en los hospitales Celestino Hernández Robau y Arnaldo Milián Castro, en Santa Clara, Villa Clara. Resultados: Se evaluaron 388 pacientes, con un predominio de edades mayores de 40 años, del sexo masculino y color de la piel blanca. El linfoma no Hodgkin tuvo mayor frecuencia; los factores de riesgo que predominaron fueron pertenecer al sexo masculino y la presencia del virus de Epstein-Barr. En las tres cuartas partes de los pacientes, la localización principal fue ganglionar. De las variedades histológicas del linfoma de Hodgkin la más frecuente fue la esclerosis nodular, mientras que para los linfomas no Hodgkin, fue el folicular. El estadio con mayor número de pacientes fue el III-b para ambos tipos de linfomas. La tercera parte de los pacientes fallecieron; el mayor número correspondió a los linfomas no Hodgkin. Conclusión: Los linfomas tienen una alta morbilidad y mortalidad en los adultos de la provincia de Villa Clara Abstract in english Introduction: Hodgkin and non-Hodgkin lymphomas are considered malignant neoplasms derived from cellular components of the immune system, in particular, of the lymphocytes and their precursors. They constitute a very heterogeneous group with broad clinical and biological, prognostic and therapeutic [...] differences. Objective: To characterize some clinical and epidemiological variables in lymphomas. Methods: A descriptive and longitudinal study was carried out from January, 2006 to December, 2010, which included all adult patients who were attended at «Dr. Celestino Hernández Robau» and «Arnaldo Milián Castro» Hospitals, in Santa Clara, Villa Clara. Results: A number of 388 patients were evaluated, with a predominance of white male, aged over 40. Non-Hodgkin lymphoma was the most frequent; male sex and the presence of Epstein-Barr virus were identified as predominant risk factors. The main localization of lymphomas was ganglionated in the three- quarter parts of patients. Nodular sclerosing was the most frequent histological variety of Hodgkin lymphomas, while for non-Hodgkin lymphomas it was follicular. The higher number of patients had III-b stage for both types of lymphomas. The third part of patients died; the higher number corresponded to non-Hodgkin lymphomas. Conclusion: Lymphomas has a high morbidity and mortality in adults from Villa Clara province

  15. Calculation of intravascular signal in dynamic contrast enhanced-MRI using adaptive complex independent component analysis.

    Science.gov (United States)

    Mehrabian, Hatef; Chopra, Rajiv; Martel, Anne L

    2013-04-01

    Assessing tumor response to therapy is a crucial step in personalized treatments. Pharmacokinetic (PK) modeling provides quantitative information about tumor perfusion and vascular permeability that are associated with prognostic factors. A fundamental step in most PK analyses is calculating the signal that is generated in the tumor vasculature. This signal is usually inseparable from the extravascular extracellular signal. It was shown previously using in vivo and phantom experiments that independent component analysis (ICA) is capable of calculating the intravascular time-intensity curve in dynamic contrast enhanced (DCE)-MRI. A novel adaptive complex independent component analysis (AC-ICA) technique is developed in this study to calculate the intravascular time-intensity curve and separate this signal from the DCE-MR images of tumors. The use of the complex-valued DCE-MRI images rather than the commonly used magnitude images satisfied the fundamental assumption of ICA, i.e., linear mixing of the sources. Using an adaptive cost function in ICA through estimating the probability distribution of the tumor vasculature at each iteration resulted in a more robust and accurate separation algorithm. The AC-ICA algorithm provided a better estimate for the intravascular time-intensity curve than the previous ICA-based method. A simulation study was also developed in this study to realistically simulate DCE-MRI data of a leaky tissue mimicking phantom. The passage of the MR contrast agent through the leaky phantom was modeled with finite element analysis using a diffusion model. Once the distribution of the contrast agent in the imaging field of view was calculated, DCE-MRI data was generated by solving the Bloch equation for each voxel at each time point. The intravascular time-intensity curve calculation results were compared to the previously proposed ICA-based intravascular time-intensity curve calculation method that applied ICA to the magnitude of the DCE-MRI data (Mag-ICA) using both simulated and experimental tissue mimicking phantoms. The AC-ICA demonstrated superior performance compared to the Mag-ICA method. AC-ICA provided more accurate estimate of intravascular time-intensity curve, having smaller error between the calculated and actual intravascular time-intensity curves compared to the Mag-ICA. Furthermore, it showed higher robustness in dealing with datasets with different resolution by providing smaller variation between the results of each datasets and having smaller difference between the intravascular time-intensity curves of various resolutions. Thus, AC-ICA has the potential to be used as the intravascular time-intensity curve calculation method in PK analysis and could lead to more accurate PK analysis for tumors. PMID:23247848

  16. Micose fungoide: relato de caso tratado com radioterapia Mycosis fungoides: case report treated with radiotherapy

    OpenAIRE

    Gustavo Nader Marta; Carolina Bueno de Gouvêa; Stéfani Bertolucci Estevam Ferreira; Samir Abdallah Hanna; Cecília Maria Kalil Haddad; João Luis Fernandes da Silva

    2011-01-01

    Micose fungoide é um tipo de linfoma não Hodgkin de células T raro que acomete primariamente a pele. Caracteriza-se pela presença de placas eritematosas que evoluem para lesões ulceradas, tumores em toda a pele ou ainda infiltração de medula óssea em estágios avançados. Como opção de tratamento para os casos iniciais, tem-se quimioterapia e corticoterapia tópica, fototerapia e radioterapia. Este estudo relata o caso de um doente com múltiplas lesões tumorais na pele já biopsiadas com diagnóst...

  17. Percutaneous Retrieval of Misplaced Intravascular Foreign Objects with the Dormia Basket: An Effective Solution

    International Nuclear Information System (INIS)

    Purpose. We report our experience of the retrieval of intravascular foreign body objects by the percutaneous use of the Gemini Dormia basket. Methods. Over a period of 2 years we attempted the percutaneous removal of intravascular foreign bodies in 26 patients. Twenty-six foreign bodies were removed: 8 intravascular stents, 4 embolization coils, 9 guidewires, 1 pacemaker lead, and 4 catheter fragments. The percutaneous retrieval was achieved with a combination of guide catheters and the Gemini Dormia basket. Results. Percutaneous retrieval was successful in 25 of 26 patients (96.2%). It was possible to remove all the intravascular foreign bodies with a combination of guide catheters and the Dormia basket. No complication occurred during the procedure, and no long-term complications were registered during the follow-up period, which ranged from 6 months to 32 months (mean 22.4 months overall). Conclusion. Percutaneous retrieval is an effective and safe technique that should be the first choice for removal of an intravascular foreign body

  18. Imminent Cardiac Risk Assessment via Optical Intravascular Biochemical Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Wetzel, D.; Wetzel, L; Wetzel, M; Lodder, R

    2009-01-01

    Heart disease is by far the biggest killer in the United States, and type II diabetes, which affects 8% of the U.S. population, is on the rise. In many cases, the acute coronary syndrome and/or sudden cardiac death occurs without warning. Atherosclerosis has known behavioral, genetic and dietary risk factors. However, our laboratory studies with animal models and human post-mortem tissue using FT-IR microspectroscopy reveal the chemical microstructure within arteries and in the arterial walls themselves. These include spectra obtained from the aortas of ApoE-/- knockout mice on sucrose and normal diets showing lipid deposition in the former case. Also pre-aneurysm chemical images of knockout mouse aorta walls, and spectra of plaque excised from a living human patient are shown for comparison. In keeping with the theme of the SPEC 2008 conference Spectroscopic Diagnosis of Disease this paper describes the background and potential value of a new catheter-based system to provide in vivo biochemical analysis of plaque in human coronary arteries. We report the following: (1) results of FT-IR microspectroscopy on animal models of vascular disease to illustrate the localized chemical distinctions between pathological and normal tissue, (2) current diagnostic techniques used for risk assessment of patients with potential unstable coronary syndromes, and (3) the advantages and limitations of each of these techniques illustrated with patent care histories, related in the first person, by the physician coauthors. Note that the physician comments clarify the contribution of each diagnostic technique to imminent cardiac risk assessment in a clinical setting, leading to the appreciation of what localized intravascular chemical analysis can contribute as an add-on diagnostic tool. The quality of medical imaging has improved dramatically since the turn of the century. Among clinical non-invasive diagnostic tools, laboratory tests of body fluids, EKG, and physical examination are still the first line of defense. However, with the fidelity of 64-slice CT imaging, this technique has recently become an option when the patient presents with symptoms of reduced arterial flow. Single photon emission computerized tomography (SPECT) treadmill exercise testing is a standard non-invasive test for decreased perfusion of heart muscle, but is time consuming and not suited for emergent evaluation. Once the invasive clinical option of catherization is chosen, this provides the opportunity for intravascular ultrasound (IVUS) imaging. As the probe is pulled through the artery, the diameter at different parts is measurable, and monochrome contrast in the constricted area reveals the presence of tissue with a different ultrasonic response. Also, via an optical catheter with a fiber-optic conductor, the possibly of spectroscopic analysis of arterial walls is now a reality. In this case, the optical transducer is coupled to a near-infrared spectrometer. Revealing the arterial chemical health means that plaque vulnerability and imminent risk could be assessed by the physician. The classical emergency use of catherization involves a contrast agent and dynamic X-ray imaging to locate the constriction, determine its severity, and possibly perform angioplasty, and stent placement.

  19. Intravascular papillary endothelial hyperplasia: magnetic resonance imaging of finger lesions

    International Nuclear Information System (INIS)

    To describe magnetic resonance imaging (MRI) features of intravascular papillary endothelial hyperplasia (IPEH), to identify findings differentiating IPEH of the finger from that of other locations, and to correlate these with pathology. Nineteen patients with 20 I.E. masses of the finger (n = 13) and other locations (n = 7) were evaluated. All patients underwent MRI, and the results were correlated with pathology. Seventeen IPEHs, including all IPEHs of the finger, were located in the subcutis, the three other lesions in the muscle layer. On T1WI, all masses were isointense or slightly hyperintense. IPEHs of the finger (n = 13) revealed focal hyperintense nodules (n = 2) or central hypointensity (n = 2) on T1WI, hypointensity with a hyperintense rim (n = 7), hyperintensity with hypointense nodules (n = 5), or isointensity with a hypointense rim (n = 1) on T2WI, and rim enhancement (n = 5), heterogeneous enhancement with nodular nonenhanced areas (n = 6), peripheral nodular enhancement (n = 1), or no enhancement (n = 1) on gadolinium-enhanced T1WI. IPEHs of other locations (n = 7) demonstrated focal hyperintense nodules (n = 5) on T1WI, hyperintensity with hypointense nodules (n = 5) or heterogeneous signal intensity (n = 2) on T2WI, and rim or rim and septal enhancement (n = 6) or peripheral nodular enhancement (n = 1). Microscopically, IPEHs were composed of thrombi that were hypointense on T2WI and papillary endothelial proliferations that showed T2 hyperintensity and enhancement. MRI of finger IPEH reveals well-demarcated subcutaneous masses with hypointensity or hypointense nodules with peripheral hyperintensity on T2WI, as well as peripheral enhancement. T1 hyperintense nodules, internal heterogeneity on T2WI, and septal enhancement are more common in IPEH of other locations. (orig.)

  20. Dose effect of guidewire position in intravascular brachytherapy

    International Nuclear Information System (INIS)

    It has been reported that the dose effects of metallic guidewires are significant in intravascular brachytherapy (IVBT) using a beta source. The purpose of this work is to investigate the dependence of these dose effects on guidewire position. The EGS4 Monte Carlo codes were used to perform the dose calculations for the 90Sr (NOVOSTE), 32P (Guidant) and 192Ir (BEST Ind.) sources with and without a guidewire in place. Guidewires were placed at various distances from the central axes of the sources. Due to the attenuation by the guidewires, a dose reduction of up to 70% behind a guidewire was observed for the beta sources, while the dose perturbation was found to be negligible for the gamma source. The dose reduction for the beta sources was found to be dependent on the guidewire location. For example, the dose reduction was 10% higher for a stainless steel guidewire located at 0.5 mm than that for the guidewire at 2 mm from the central axis of the source. The portion of the target volume affected (shadowed) dosimetrically by the guidewire was reduced when the guidewire was positioned farther away from the source. The shadow volume (in which the dose reduction occurs) can be reduced by up to 45% as the guidewire is moved away from the source axis from 0.5 mm to 2 mm. The dosimetric perturbations due to the presence of a metallic guidewire as well as their dependence on guidewire location should be considered in designing a new IVBT delivery device, in analysing the treatment efficacy, and/or in dose prescription for a beta source. (author)

  1. Intravascular papillary endothelial hyperplasia: magnetic resonance imaging of finger lesions

    Energy Technology Data Exchange (ETDEWEB)

    Sung, Jinkyeong; Kim, Jee-Young [The Catholic University of Korea, Department of Radiology, St. Vincent' s Hospital, College of Medicine, Suwon, Gyeonggi-do (Korea, Republic of); Yoo, Changyoung [The Catholic University of Korea, Department of Hospital Pathology, St. Vincent' s Hospital, College of Medicine, Suwon, Gyeonggi-do (Korea, Republic of)

    2016-02-15

    To describe magnetic resonance imaging (MRI) features of intravascular papillary endothelial hyperplasia (IPEH), to identify findings differentiating IPEH of the finger from that of other locations, and to correlate these with pathology. Nineteen patients with 20 I.E. masses of the finger (n = 13) and other locations (n = 7) were evaluated. All patients underwent MRI, and the results were correlated with pathology. Seventeen IPEHs, including all IPEHs of the finger, were located in the subcutis, the three other lesions in the muscle layer. On T1WI, all masses were isointense or slightly hyperintense. IPEHs of the finger (n = 13) revealed focal hyperintense nodules (n = 2) or central hypointensity (n = 2) on T1WI, hypointensity with a hyperintense rim (n = 7), hyperintensity with hypointense nodules (n = 5), or isointensity with a hypointense rim (n = 1) on T2WI, and rim enhancement (n = 5), heterogeneous enhancement with nodular nonenhanced areas (n = 6), peripheral nodular enhancement (n = 1), or no enhancement (n = 1) on gadolinium-enhanced T1WI. IPEHs of other locations (n = 7) demonstrated focal hyperintense nodules (n = 5) on T1WI, hyperintensity with hypointense nodules (n = 5) or heterogeneous signal intensity (n = 2) on T2WI, and rim or rim and septal enhancement (n = 6) or peripheral nodular enhancement (n = 1). Microscopically, IPEHs were composed of thrombi that were hypointense on T2WI and papillary endothelial proliferations that showed T2 hyperintensity and enhancement. MRI of finger IPEH reveals well-demarcated subcutaneous masses with hypointensity or hypointense nodules with peripheral hyperintensity on T2WI, as well as peripheral enhancement. T1 hyperintense nodules, internal heterogeneity on T2WI, and septal enhancement are more common in IPEH of other locations. (orig.)

  2. Can rotational thromboelastometry predict septic disseminated intravascular coagulation?

    Science.gov (United States)

    Koami, Hiroyuki; Sakamoto, Yuichiro; Ohta, Miho; Goto, Akiko; Narumi, Showgo; Imahase, Hisashi; Yahata, Mayuko; Miike, Toru; Iwamura, Takashi; Yamada, Kosuke Chris; Inoue, Satoshi

    2015-10-01

    Rotational thromboelastometry (ROTEM), known as point-of-care testing, has been incorporated into various kinds of postsurgical management. However, the utility of ROTEM for rapid diagnosis of sepsis-induced disseminated intravascular coagulation (DIC) has not been investigated. This retrospective study includes 13 sepsis patients who underwent ROTEM in our emergency department in 2013. All patients were divided into two groups on the basis of the presence of DIC diagnosed by the Japanese Association for Acute Medicine (JAAM) DIC score. We evaluated the demographics, clinical characteristics, laboratory data, ROTEM test and outcomes for each patient. The correlations between JAAM DIC score and significantly different parameters by univariate analysis and receiver operating characteristic (ROC) analysis were performed to assess the accuracy of the variables. There were seven and six patients in the DIC group and non-DIC group, respectively. The DIC group showed significantly longer prothrombin times, international normalized ratio of prothrombin time and clotting times (CTs) in the EXTEM test, and higher fibrinogen and fibrin degradation products and D-dimer. The CT in EXTEM test was correlated more with JAAM DIC score (r = 0.798), than the standard coagulation test. These parameters were accurate predictors in the diagnosis of septic DIC, with an AUC of 0.952, and a cut-off value of more than 46.0 s, resulting in a sensitivity of 100.0% and a specificity of 83.3%. CT in the EXTEM test was a single reliable indicator of sepsis-induced DIC diagnosed by the JAAM DIC score, and strongly associated with severity of DIC. PMID:26196197

  3. Linfoma primario de célula B grande de próstata. Comunicación de un caso

    Directory of Open Access Journals (Sweden)

    Salim Antonio Villacis Fonseca

    2012-01-01

    Full Text Available El linfoma prostático representa 0.09% de los tumores malignos de ese órgano. La forma de presentación habitual consta de signos de prostatismo y se descubre, predominantemente, de manera incidental por medio de tejido obtenido por resección transuretral de próstata. La sensibilidad de la biopsia transrectal es de 22%. El linfoma de próstata casi siempre es indistinguible de un adenocarcinoma, e incluso, puede encontrarse una próstata pétrea, fija y mal delimitada. En el estudio anatomopatológico se observan intensos infiltrados linfohistiocitarios. En estos pacientes debe tomarse en cuenta la posible existencia de una afectación linfática sistémica, por lo que es conveniente realizar mielograma, biopsia de médula ósea, tomografía computada toracoabdominal y gammagrama óseo. El diagnóstico se corrobora por medio de inmunohistoquímica con la detección de linfocitos B en el inmunomarcaje. El tratamiento consiste en la desobstrucción con alivio de los síntomas urinarios, así como de quimioterapia a base de ciclofosfamida, adriamicina, vincristina y prednisona con rituximab. Se comunica un caso de linfoma prostático destacando su infrecuencia con el fin de llamar la atención de la comunidad médica para realizar un abordaje diagnóstico y terapéutico adecuado. En el caso que se comunica, tras seis ciclos de quimioterapia, no se encontró actividad tumoral ni adenopatías retroperitoneales en los seguimientos radiológicos.

  4. Expresión del factor de transcripción SOX11: Su implicancia en el linfoma de células del manto

    Directory of Open Access Journals (Sweden)

    Alejandro Roisman

    2014-04-01

    Full Text Available El gen SOX11, perteneciente a la familia de genes SOXC, es un factor de transcripción involucrado en la neurogénesis embrionaria y el remodelado tisular, participando asimismo en el control de la proliferación celular. Su rol en la linfomagénesis es desconocido. Estudios recientes han mostrado expresión proteica nuclear aberrante y sobreexpresión de los niveles de transcripto de SOX11 en pacientes con linfoma de células del manto (LCM. Si bien la mayoría de estos linfomas presentan un curso clínico agresivo, existe un subgrupo de pacientes con enfermedad indolente, sugiriendo una mayor heterogeneidad de esta patología. Actualmente, existen contradicciones respecto de la asociación entre la expresión del gen SOX11 y la evolución clínica del LCM; mientras algunos autores relacionan la ausencia de expresión de SOX11 con buen pronóstico, otros lo encuentran asociado a un curso clínico adverso. Esta diferencia en la expresión estaría relacionada a mecanismos epigenéticos, metilación del ADN y modificaciones a nivel de histonas, que permitirían la expresión aberrante de este gen en algunas neoplasias linfoides, incluyendo LCM. La profundización del conocimiento del gen SOX11 en LCM hará factible, sin duda, lograr una mayor comprensión de los mecanismos involucrados en la patogénesis y/o progresión de este linfoma, así como del rol de SOX11 en estos procesos.

  5. Linfoma cutâneo de células B: relato de caso Cutaneous B-cell lymphoma: a case report

    Directory of Open Access Journals (Sweden)

    Mariana de Gusmão Nunes

    2004-12-01

    Full Text Available Os linfomas cutâneos são classificados em linfomas de células B ou de células T, sendo os primeiros menos freqüentes. O linfoma cutâneo de células B (LCCB pode ser primário ou secundário, tendo o último história natural mais agressiva, com pior prognóstico. Os autores apresentam um caso de LCCB secundário com três anos de evolução, curso indolente, sem envolvimento de outros órgãos além da pele, com ótima resposta ao tratamento quimioterápico. A distinção entre LCCB primário e secundário é muito difícil de ser realizada, uma vez que eles são clínica e histopatologicamente indistinguíveis. Deve-se sempre pesquisar o acometimento de órgãos internos para então definir o prognóstico.Cutaneous lymphomas are classified as either type B cell or T cell lymphoma, the former type being less frequent. Cutaneous B cell lymphoma (CBCL may be primary or secondary. The latter has a more aggressive natural history with a worse prognostic. In this paper, the authors present a secondary CBCL case with a three-year evolution, indolent course, without involvement of other organs beside the skin and with optimal response to chemotherapeutic treatment. The distinction between primary and secondary CBCL is very difficult to determine insofar as they are clinically and histopathologically indistinguishable. It is always necessary to investigate whether internal organs have been affected prior to defining the prognosis.

  6. Infiltração do sistema nervoso central e das meninges nos linfomas com representação leucemica

    OpenAIRE

    de Freitas, Marcos R.G.; Pedro F. Moreira Filho; Herbert Praxedes; Myriam D. Hahn

    1981-01-01

    Os autores fazem referência a 4 pacientes com representação leucêmica no decurso de linfomas malignos que apresentaram infiltração de células neoplasicas no sistema nervoso central e meninges. É feito o estudo anatomopatoló-gico, encontrando-se em 2 deles a formação de nódulos leucêmicos no parênquima nervoso. Nos outros dois, houve regressão total de sintomatologia neurológica com o uso do metotrexate por via intratecal.

  7. Infiltração do sistema nervoso central e das meninges nos linfomas com representação leucemica

    Directory of Open Access Journals (Sweden)

    Marcos R. G. de Freitas

    1981-12-01

    Full Text Available Os autores fazem referência a 4 pacientes com representação leucêmica no decurso de linfomas malignos que apresentaram infiltração de células neoplasicas no sistema nervoso central e meninges. É feito o estudo anatomopatoló-gico, encontrando-se em 2 deles a formação de nódulos leucêmicos no parênquima nervoso. Nos outros dois, houve regressão total de sintomatologia neurológica com o uso do metotrexate por via intratecal.

  8. Linfoma de células B tipo MALT, de baixo-grau, primitivo da dura-máter: relato de caso

    OpenAIRE

    Raso Pedro; Monteiro Eduardo Rossi; Tafuri Alexandre

    2004-01-01

    Relatamos um caso raro de linfoma maligno não-Hodgkin, nodular e de baixo grau, tipo MALT, com aspecto morfológico e imuno-histoquímico linfoplasmocitóide (classificação de REAL), de imunofenótipo de linfócitos B e monoclonalidade para a cadeia leve de imunoglobulina Kappa, com índice de proliferação < 10% (baixo grau). O tumor era primitivo da dura-máter parietal esquerda, em mulher de 36 anos de idade, cujos sintomas neurológicos surgiram quatro meses antes da cirurgia. Após a cirurgia, foi...

  9. A case of giant cavernous hemangioma of the liver complicated by intravascular coagulopathy.

    Directory of Open Access Journals (Sweden)

    Watanabe,Makoto

    1978-04-01

    Full Text Available A case of liver hemangioma complicated by intravascular coagulopathy is presented because of the rarity of the association. Hemangioma of the liver was suspected by palpation of the liver tumor, scintigraphy and x-ray examination, and confirmed by selective hepatic arteriography in combination with exploratory laparotomy. Intravascular coagulopathy was established by demonstrating secondary fibrinolysis and consumption of platelets and coagulation factors. Unconjugated hyperbilirubinemia due to micro-angiopathic hemolytic anemia was also present. The clinical course of the clotting abnormalities was basically a chronic one with an occasional acute or subacute defibrination process associated with further enlargement of the hepatic tumor. These provide sufficient evidence that the intravascular coagulopathy was closely related with the hemangioma in the liver. Neither ligation of a presumed nutritional artery of the hemangioma nor radiation therapy caused any demonstrable reduction in the tumor size.

  10. Hepatic abscess-associated Clostridial bacteraemia presenting with intravascular haemolysis and severe hypertension.

    Science.gov (United States)

    Lim, Andrew George; Rudd, Kristina Elizabeth; Halliday, Melissa; Hess, John Rider

    2016-01-01

    Clostridium perfringens bacteraemia is a potentially fatal condition, and its early identification is paramount to maximise chances of survival. Prompt recognition of intravascular haemolysis, a known complication of C. perfringens bacteraemia, can help guide clinical decision-making before microbiology data becomes available. We present a novel finding of severe hypertension in a fatal case of Clostridial bacteraemia with massive haemolysis. A 58-year-old man with no known medical history presented to the emergency department with malaise, fever and hypertension. He developed abdominal pain and a hepatic abscess was identified on CT imaging. Within 4?h of presentation, he developed massive intravascular haemolysis, extreme hypertension, pulmonary oedema and respiratory failure. He died less than 8?h after presentation. His blood cultures subsequently grew C. perfringens. This case underscores the importance of early recognition of intravascular haemolysis complicating C. perfringens bacteraemia, and discusses the rare complication of hypertensive emergency in this setting. PMID:26823354

  11. Plasma volume, intravascular albumin and its transcapillary escape rate in patients with extensive skin disease

    DEFF Research Database (Denmark)

    Parving, H H; Worm, A M; Rossing, N

    1976-01-01

    Plasma volume and plasma concentration and transcapillary escape rate of albumin (TER alb), i.e. the fraction of intravascular mass of albumin that passes to the extravascular space per unit time, were determined using 125I-labelled human albumin in eight patients with extensive skin disease......, 25-60 mg per day. Plasma albumin concentration, plasma volume and intravascular mass of albumin were unchanged, while TER alb decreased significantly during treatment, mean 5-9 +/- 0-8 (s.d.) % X h-1, (P less than 0-01). It is suggested that displacement of albumin into the skin and loss of albumin...... from the skin are the dominating mechanisms of the reduction in the intravascular albumin mass in patients with extensive skin disease....

  12. Accumulation of /sup 99m/Tc-sulfur colloid by the lung and kidney following disseminated intravascular coagulation

    Energy Technology Data Exchange (ETDEWEB)

    Smith, F.W.; Brown, R.G.; Ash, J.M.; Gilday, D.L.

    1980-06-01

    A patient is described who demonstrated accumulation of /sup 99m/Tc-sulfur colloid in both the lung and kidney following treatment for disseminated intravascular coagulation. This phenomenon has been demonstrated experimentally in animals following the induction of disseminated intravascular coagulation, but to our knowledge has not been previously described in humans.

  13. Accumulation of /sup 99m/Tc-sulfur colloid by the lung and kidney following disseminated intravascular coagulation

    International Nuclear Information System (INIS)

    A patient is described who demonstrated accumulation of /sup 99m/Tc-sulfur colloid in both the lung and kidney following treatment for disseminated intravascular coagulation. This phenomenon has been demonstrated experimentally in animals following the induction of disseminated intravascular coagulation, but to our knowledge has not been previously described in humans

  14. Alterações histológicas e imunoistoquímicas em pâncreas de ratos normais e diabéticos tratados com Syzygium cumini

    Directory of Open Access Journals (Sweden)

    Schossler Deila Rosely Carneiro

    2004-01-01

    Full Text Available Avaliou-se o efeito da administração oral do extrato da casca de Syzygium cumini sobre o pâncreas de ratos normais e diabéticos. Os animais foram divididos em grupo controle (C, controle tratado (CT, diabético controle (DC e diabético tratado (DT. Os tratados receberam dose diária de 1g kg-1 de peso vivo, durante 30 dias. Os animais foram submetidos à eutanásia e o pâncreas retirado para análise histológica e imunoistoquímica para insulina. Neste estudo observou-se uma diminuição (P<0,001 no número e tamanho das ilhotas pancreáticas, alteração na sua citoarquitetura e diminuição (P<0,0001 do número de células com marcação positiva para insulina nos animais diabéticos em relação aos não diabéticos. Não foi observada diferença entre os animais dos grupos DC e DT e entre os dos grupos C e CT. Estes resultados indicam que o extrato da casca de Syzygium cumini não afeta o número, o tamanho e a citoarquitetura das ilhotas pancreáticas e não promove um aumento no número de células beta em animais tratados com a planta.

  15. El avance del derecho a la buena Administración en el Tratado de Lisboa

    OpenAIRE

    Guillem Carrau, Javier

    2010-01-01

    El Tratado de Lisboa liga directamente el derecho a la buena administración con los principios de trasparencia y participación. Este avance debe garantizar que el derecho a la buena administración no quede limitado por un excesivo carácter programá

  16. Intravascular balloon to minimize blood loss during total hip replacement in a Jehovah's Witness.

    Science.gov (United States)

    Mangar, Devanand; Shube, Sam; Omar, Hesham; Kolla, Jaya; Karlnoski, Rachel A; Camporesi, Enrico M

    2011-02-01

    Intermittent intravascular occlusive balloons are commonly used to minimize bleeding in cases where massive blood loss is anticipated. However, the efficiency and safety of balloon occlusion remains unclear for elective procedures, and several cases of distal thrombosis have been reported. A case of intra-arterial occlusive balloon that was selectively placed preoperatively to minimize bleeding in a patient during total hip replacement is presented. Use of an external tourniquet was not feasible for this patient. The balloon was inflated to a minimum volume to achieve intravascular occlusion and was periodically deflated to minimize the risk of postoperative complications. A surgical field with minimal blood loss was created. PMID:21296252

  17. Leiomyosarcoma of the Uterus with Intravascular Tumor Extension and Pulmonary Tumor Embolism

    International Nuclear Information System (INIS)

    We report the case of a 48-year-old woman presenting with recurrent uterine leiomyosarcoma (LMS) associated with right iliac vein and inferior vena cava (IVC) invasion and left lower lobe pulmonary tumor embolus. Because the prognosis and treatment differ from that of thrombotic pulmonary emboli, the differentiating imaging characteristics of intravascular tumor embolism are reviewed. To our knowledge, only two other cases of intravenous uterine leiomyosarcomatosis have been described in the existing literature, and this is the first reported case of the entity with associated intravascular tumor embolism

  18. Coagulación intravascular diseminada fulminante en una paciente con leucemia promielocítica aguda

    Directory of Open Access Journals (Sweden)

    Ivette Martínez López

    2002-10-01

    Full Text Available Se comunicó el caso de una paciente con diagnóstico de coagulación intravascular diseminada, de tipo fulminante, cuya causa resultó ser una leucemia promielocítica aguda, de la variedad hipergranular. Se observó, clínicamente, un comportamiento agresivo de la enfermedad que ocasionó la muerte del paciente, en 72 h, por hemorragias viscerales masivas.The case of a patient with diagnosis of fulminant disseminated intravascular coagulation caused by a hypergranular acute promyelocytic leukaemia was reported. An aggressive behavior of the disease that caused the death of the patient in 72 hours due to visceral massive hemorrhages was clinically observed.

  19. Recent acquisitions in the pathophysiology, diagnosis and treatment of disseminated intravascular coagulation

    Directory of Open Access Journals (Sweden)

    Lippi Giuseppe

    2006-02-01

    Full Text Available Abstract Disseminated intravascular coagulation (DIC is a disorder characterized by both acute generalized, widespread activation of coagulation, which results in thrombotic complications due to the intravascular formation of fibrin, and diffuse hemorrhages, due to the consumption of platelets and coagulation factors. Systemic activation of coagulation may occur in a variety of disorders, including sepsis, severe infections, malignancies, obstetric or vascular disorders, and severe toxic or immunological reactions. In this review, we briefly report the present knowledge about the pathophysiology and diagnosis of DIC. Particular attention is also given to the current standard and experimental therapies of overt DIC.

  20. IMPACT OF OBESITY ON ENDOTOXIN-INDUCED DISSEMINATED INTRAVASCULAR COAGULATION.

    Science.gov (United States)

    Duburcq, Thibault; Tournoys, Antoine; Gnemmi, Viviane; Hubert, Thomas; Gmyr, Valery; Pattou, François; Jourdain, Mercé

    2015-10-01

    An early activation of coagulation and fibrinolysis occurs during sepsis, leading to the syndrome of disseminated intravascular coagulation (DIC). Obesity has been demonstrated to be a hypercoagulable and hypofibrinolytic state, but its impact on DIC has never been studied. In this study, we aimed to determine if obesity impairs DIC in an acute endotoxic shock model using minipigs. This was a prospective, comparative, and experimental ancillary study approved by the Animal Ethics Committee. Pigs were chosen as a clinically relevant species, resembling humans in coagulation reactions. Four groups of five "Yucatan" minipigs were studied: lean and obese control groups, a lean lipopolysaccharide (LPS) group receiving Escherichia coli endotoxin (LPS), and an obese LPS group receiving the same endotoxin dose. We measured standard coagulation parameters (prothrombin time [PT], platelet count, and fibrinogen levels), thrombin-antithrombin complexes, tissue-type plasminogen activator, and plasminogen activator inhibitor-1. All measurements were performed at baseline and 30, 60, 90, 150, and 300 min. Results were given as median with interquartile ranges. At baseline, platelet count (477 [428 - 532] G/L vs. 381 [307 - 442] G/L; P = 0.005) and fibrinogen levels (4.6 [3.8 - 5.2] g/L vs. 2 [1.8 - 2.9] g/L; P < 0.001) were significantly higher, whereas PT (80% [76% - 92%] vs. 96% [89% - 100%]; P = 0.01) was significantly lower in obese pigs compared with lean pigs. In the LPS groups, administration of endotoxin resulted in a typical hypokinetic shock with DIC. The decrease in coagulation parameters (PT, platelet count, and fibrinogen levels) and the increase in thrombin-antithrombin complexes (581 [382 - 1,057] μg/mL vs. 247 [125 - 369] μg/mL at 150 min; P = 0.03) were significantly more important in the obese LPS group compared with those in the lean LPS group. Concerning the fibrinolytic reaction, we found a slightly more elevated increase of plasminogen activator inhibitor-1 in the obese LPS group at 300 min (481 [365 - 617] ng/mL vs. 355 [209 - 660] ng/mL; P = 0.66). In our model of endotoxic shock, obese pigs developed a more severe DIC with a more severe procoagulant response. PMID:26125085

  1. Enfermedad Celiaca y Obstrucción Intestinal por Linfoma de Células T / Celiac disease and intestinal obstruction by T cell lymphoma

    Scientific Electronic Library Online (English)

    Augusto, Vera; Oscar, Frisancho; Alejandro, Yábar; Wilmer, Carrasco.

    2011-07-01

    Full Text Available Paciente varón de 55 años, raza blanca (ascendencia española), natural y procedente de Ayacucho, que ingresó por una enfermedad de seis meses de evolución, caracterizada por dolor abdominal tipo cólico y baja ponderal de 10 Kg. Había estado hospitalizado seis meses antes y dado de alta con el diagnó [...] stico de síndrome de intestino irritable. Entre sus antecedentes refería intolerancia a la lactosa y artritis reumatoidea. Los exámenes mostraron: Hb:12 g/dl, leucocitos: 5260 cel/mm, abastonados: 11%, albúmina: 2,7 mg/ml y VSG: 33mm/h. El resto de exámenes -incluyendo los marcadores tumorales- fueron normales. El tránsito gastrointestinal mostraba las asas delgadas con fragmentación del bario y dilatación focal moderada de un asa yeyunal distal. La tomografía de tórax, abdomen y pelvis sin alteraciones; Rx tórax normal. La colonoscopia fue normal; el íleon tenía pocos pliegues y pequeñas nodulaciones, las biopsias indicaron "ileitis inespecífica". La endoscopia mostró gastritis y una cicatriz de úlcera duodenal; la mucosa duodenal mostraba áreas con aspecto de mosaico rosado-blanquecino. La biopsia duodenal evidenció acortamiento de vellosidades, infiltrado inflamatorio crónico e incremento de linfocitos intraepiteliales, hallazgos compatibles con los criterios de celiaquía Marsh-tipo 3. Los anticuerpos IgA antiendomisio y antitransglutaminasa tisular estaban incrementados. Durante su hospitalización aumentó el dolor y aparecieron signos de obstrucción. En la laparotomía se encontraron una tumoración yeyunal estenosante y una perforación adyacente. El espécimen mostró un linfoma intestinal de células T. Se ha demostrado que existen más celiacos subclínicos que celiacos con esprue clásico; el conocimiento de esta situación nos debe llevar a tenerla presente por sus complicaciones o asociaciones, una de las cuales es el linfoma primario intestinal. Abstract in english A male patient, 55 years old, born in Ayacucho, with Spanish ancestors, was hospitalized through emergency referring abdominal pain, and 10 kilograms weight loss. Six months before he was diagnosed as having irritable bowel syndrome. His previous diseases were rheumatoid arthritis and intolerance to [...] lactose. Laboratory results were: Hb 12 gr./dL, white cells 5200 per mm3, albumin 2.7 gr./dL, erythrocyte sedimentation rate 32 mm/hr., and tumor markers were negative. Radiographic study of the small bowel showed barium fragmentation, and a focal dilation in distal jejunum. Chest X-ray and CT scan of thorax, abdomen and pelvis were normal. Colonoscopy was normal for colonic mucosa, but in ileum it showed an irregular mucosa, little nodules and fewer folds than usual. Biopsy from ileum demonstrated unspecific inflammation. Upper endoscopy showed gastritis, a duodenum scar ulcer and an irregular mosaic pattern pink and white. Duodenum biopsy demonstrated short villi, chronic inflammation and an increase in the number of intraepithelial lymphocytes, all these was consistent with celiac disease Marsh 3. Antibodies anti-endomisium and anti-transglutaminase were positive. After some days he developed signs of bowel obstruction and was operated. A tumor was found in jejunum with a bowel perforation. Pathological study showed a small bowel T-cell lymphoma. Fortunately this patient did well, and was sent home to continue treatment on ambulatory basis. Celiac disease is more common than what is thought, and it has been demonstrated that there are more persons with subclinical celiac disease, than those with the typical clinical pattern. It is necessary to be aware of this disease to improve diagnosis in order to avoid late complications as small bowel lymphoma.

  2. Linfoma T intestinal monomórfico CD56+. Primer caso informado en Colombia y revisión de la literatura / Monomorphic Intestinal T-Cell Lymphoma. First reported case in Colombia and review of the literature

    Scientific Electronic Library Online (English)

    Diana Lucía, Martínez-Baquero; Leandro, Galvis-Moreno; Jinneth, Acosta-Forero; Orlando, Ricaurte-Guerrero.

    2015-01-01

    Full Text Available Se informa el caso de una mujer de 80 años con hallazgo incidental de masa abdominal en mesogastrio. Se le realiza resección de intestino delgado por sospecha de absceso con síndrome adherencial. El estudio patológico de la pieza quirúrgica demostró compromiso por linfoma no Hodgkin T monomórfico CD [...] 56+. Los linfomas T del tubo digestivo son inusuales; corresponden al 5% de las neoplasias linfoides de esta localización. El linfoma intestinal T monomórfico CD56+ corresponde a 10-20% de los linfomas T intestinales. Se presenta en regiones donde la enfermedad celiaca es infrecuente y no se asocia a enteropatía. Su curso es agresivo y habitualmente se manifiesta como una emergencia quirúrgica por obstrucción o perforación intestinal. Abstract in english 80 year old woman with incidental finding of abdominal mass in midgut, in which small bowel resection is performed for suspected abscess associated to surgical adhesions. Pathological examination of the surgical specimen showed a monomorphic CD56+ T cell lymphoma. T-cell lymphomas of the digestive t [...] ract are rare, accounting for 5% of all lymphoid neoplasms in this location. Monomorphic CD56+ intestinal T cell lymphoma corresponds to 10 - 20% of T cell intestinal lymphomas. This tumor occurs in regions where celiac disease is rare and it is not associated with enteropathy. Its course is aggressive and usually manifests as a surgical emergency by intestinal obstruction or perforation.

  3. Linfoma de Burkitt: informe de un caso diagnosticado por laparotomía Burkitt's lymphoma: report of a case diagnosed by laparotomy

    Directory of Open Access Journals (Sweden)

    Rafael Pinilla González

    2008-12-01

    Full Text Available El linfoma de Burkitt no endémico es un tumor de frecuente localización abdominal, por lo que se debe tener presente ante cualquier masa intraabdominal. Aunque el tratamiento de elección es la quimioterapia, existe controversia respecto del papel que debe desempeñar la cirugía, especialmente en casos donde el diagnóstico se establece durante una laparotomía exploradora. Este fue el caso de una adolescente de 14 años que presentó una masa hipogástrica y otra menor en la fosa ilíaca derecha. Algunos autores no aceptan la cirugía y añaden que puede retrasar y complicar el tratamiento quimioterápeutico, mientras que otros autores defienden la cirugía reductora de masa tumoral asociada a la quimioterapia. Esta controversia es especialmente importante cuando el diagnóstico se establece en el curso de una laparotomía exploradora, durante la cual hay que decidir si extirpar la masa tumoral o no hacerlo. En nuestro caso decidimos extirpar todo el tumor macroscópico. La buena evolución de nuestra paciente y los resultados comunicados apoyan esta postura.Non-endemic Burkitt's lymphoma is a tumor of frequent abdominal localization that should be taken into consideration before any intraabdominal mass. Although chemotherapy is the election treatment, there is controversy as regards the role surgery should play, specially in those cases where the diagnosis is established by explorative laparotomy. This was the case of a 14-year-old adolescent that presented a hypogastric mass and another lower mass in the right iliac fossa. Some authors do not accept surgery and state that it may delay and complicate chemotherapy, whereas other authors defend the tumoral mass-reducing surgery associated with chemotherapy. This controversy is particularly important when the diagnosis is made in the course of an explorative laparotomy and it should be decided wether to remove the tumoral mass or not. In our case, it was decided to remove the whole macroscopic tumor. The good evolution of our patients and the results attained support this position.

  4. Aspectos epidemiológicos, clínicos e anatomopatológicos do linfoma em bovinos: 128 casos (1965-2013

    Directory of Open Access Journals (Sweden)

    Welden Panziera

    2014-09-01

    Full Text Available Por meio de um estudo retrospectivo, os aspectos epidemiológicos, clínicos e anatomopatológicos de 128 casos de linfoma bovino são descritos. Dos protocolos que informavam o sexo (n=111, 84,7% correspondiam a fêmeas e 15,3% a machos. Dos protocolos em que constava a raça (n=108, a mais prevalente foi a holandesa (63%. Em relação à idade (n=107, houve uma variação entre um e 14 anos. A maioria dos bovinos era adulta (89,7% e a maior concentração dos casos ocorreu ao redor de 5-8 anos (57,9%. Em relação aos sinais clínicos (n=89, linfadenomegalia foi o achado mais frequentemente observado (74,1%. Outros sinais clínicos, principalmente aqueles relacionados com os sistemas respiratório (dispneia, estertoração pulmonar e taquipneia, cardiovascular (taquicardia, edema subcutâneo e pulso venoso positivo, digestório (atonia ruminal, timpanismo e diarreia e nervoso (paresia dos membros pélvicos e andar cambaleante, foram pouco prevalentes. Na necropsia (n=125, 71,2% dos bovinos apresentavam aumento de volume dos linfonodos; essa linfadenomegalia foi classificada como localizada em 89,6% dos casos e generalizada em 10,3% dos casos. Dos protocolos que informavam os linfonodos acometidos (n=58, a distribuição foi a seguinte: mesentéricos (51,7%, mediastínicos (37,9%, pré-escapulares (29,3%, ilíacos internos (27,6%, inguinais superficiais (25,8% e traqueobrônquicos (18,9%. Além dos linfonodos, outros órgãos comumente afetados pelo linfoma neste estudo incluíram: coração (40%, fígado (15,2%, rim (14,4%, abomaso (12,8%, útero (11,2%, intestino (10,4% e pulmão (7,2%. A presença de massas tumorais no canal vertebral foi observada em poucos casos (3,2%. Com base na epidemiologia e na localização das lesões, a maioria dos casos (96% foi classificada como linfoma enzoótico e o restante (4% como linfoma esporádico. Os resultados encontrados neste estudo irão auxiliar clínicos de grandes animais e patologistas veterinários na suspeita e no diagnóstico definitivo do linfoma na espécie bovina.

  5. Comparative study of histopathology and immunohistochemistry of indefinite round cell cutaneous tumors and characterization of canine lymphoma / Estudo comparativo de histopatologia e imuno-histoquímica de tumores indefinidos de células redondas e caracterização de linfoma canino

    Scientific Electronic Library Online (English)

    L.H.A., Machado; M.I.P., Palumbo; F.S., Zahn; R.L., Amorim; M.R., Farias; J., Werner; R., Torres Neto; J.C., Rodrigues; F.C., Oliveira.

    2015-02-01

    Full Text Available Com o objetivo de sanar algumas dúvidas na área da oncologia veterinária, o presente artigo pretende comparar os resultados dos exames histopatológicos e imuno-histoquímicos de neoplasias de células redondas inespecíficas, realizar imunofenotipagem dos casos de linfoma canino e determinar o grau de [...] proliferação e apoptose de linfomas. Dos 11 animais que apresentaram diagnóstico imuno-histoquímico de linfoma, cinco foram diagnosticados como linfoma por coloração HE das lâminas histopatológicas e seis foram classificados como neoplasia de células redondas inespecíficas. Todos os casos submetidos ao exame imuno-histoquímico foram de linfomas de células-T. Houve uma correlação positiva entre a proliferação celular e apoptose. A comparação entre os resultados histopatológicos e imuno-histoquímicos obtidos nos casos analisados sugeriu que a imuno-histoquímica é essencial para a diferenciação das neoplasias de células redondas. Abstract in english With the purpose of shedding light on some doubts in veterinary oncology, the present article intends to compare the results of histopathological and immunohistochemical examinations of unspecific round cell neoplasia, to realize immunophenotyping of canine lymphoma cases, to establish the T or B or [...] igin of neoplastic cells, and to determine the degree of proliferation and apoptosis of lymphomas by immunohistochemistry. Of 11 animals presenting immunohistochemical diagnosis of lymphoma, five had been diagnosed as Lymphoma by HE staining of histopathological slides and six had been classified as unspecific round cell neoplasia. All cases submitted to immunohistochemical examination were T-cell lymphomas. There was a positive correlation between cell proliferation and apoptosis. The comparison among histopathological and immunohistochemical results obtained in the cases examined in the present study suggested that immunohistochemistry is essential for the differentiation of round cell neoplasia.

  6. Características clínicas y resultados terapéuticos de linfomas no Hodgkin de células grandes B mediastinal primarios Clinical features and therapeutic results of primary mediastinal large B- cells non-Hodgkin's lymphomas

    Directory of Open Access Journals (Sweden)

    Reysel Chávez Medina

    2011-06-01

    Full Text Available Se realizó un estudio observacional, descriptivo y retrospectivo para evaluar las características clinicobiológicas y los resultados terapéuticos del linfoma de células grandes B mediastinal primario, en 34 pacientes atendidos en el Hospital Clinicoquirúrgico "Hermanos Ameijeiras" desde junio de 1989 a febrero de 2009. Se halló predominio del sexo femenino (61,8 %, edad promedio de 31,5 años (19 a 61 años y de la raza blanca (70,6 %. Fueron más frecuentes los estadios localizados (67,7 %, sin síntomas B (64,7 % y con gran masa tumoral (70,6 %. La supervivencia global y la supervivencia libre de progresión a los 5 años fueron 53,4 y 43,4 %, respectivamente. La supervivencia global a los 3 años de los pacientes tratados con MACOPB/VACOPB, CHOP y R-CHOP fue de 77,7; 30,4 y 100 %, respectivamente. Se comprobó que los pacientes tratados con MACOPB/VACOPB tuvieron mejores resultados que los tratados con CHOP. El índice pronóstico internacional ajustado a la edad no fue predictor de supervivencia. En el análisis multivariable, el único predictor de supervivencia fue el tratamiento utilizado (CHOP contra MACOPB. El uso rutinario de la radioterapia no tuvo impacto significativo en la supervivencia global ni en la supervivencia libre de progresión a los 5 años.A retrospective, descriptive and observational study was conducted to assess the clinical-biological features and the therapeutic results of the primary mediastinal of large B cells lymphoma in 34 patients seen in the "Hermanos Ameijeiras" Clinical Surgical Hospital from June, 1989 to February, 2009. There was predominance of female sex (61.8 %, mean age of 31.5 years (19 to 61 years and of white race (70.6 %. The localized stages were more frequent (67.7 %, without B symptoms (64.7 % and with a large tumor mass (70.6 %. Global survival and the free of progression survival at five years were of 53.4 and 43.4 %, respectively. The global survival at three years of the patients treated with MACOPB/VACOPB, CHOP and R-CHOP was of 77.7; 30.4 and 100 %, respectively. It was proved that patients treated with MACOPB/VACOPB had better results than those treated with CHOP. Age-adjusted international prognostic rate was not a survival predictor. In multivariable analysis, the only survival predictor was the applied (CHOP versus MACOPB. The routine use of radiotherapy has neither a significant impact on the global survival nor on the free of progression survival at five years.

  7. Intravascular ultrasound-guided revascularization of a chronically occluded left main coronary artery

    OpenAIRE

    De Caterina, Alberto Ranieri; Cuculi, Florim; Banning, Adrian P.

    2013-01-01

    We describe a case of a left main coronary artery (LMCA) chronic total occlusion (CTO), which we elected to treat through percutaneous coronary intervention (PCI). In this case report, we briefly review the prevalence of LMCA CTO, discuss the feasibility of PCI versus surgical revascularization and highlight the importance of intravascular ultrasound in the guidance of these complex procedures.

  8. Low-level He-Ne laser in intravascular irradiation treatment of schizophrenia

    Science.gov (United States)

    Zhou, Yu-Xue; Fu, Zheng-Hua

    1998-11-01

    Intravascular low level He-Ne laser irradiation is a new therapy developed in recent years. In our hospital it was applied in the treatment and observation of 220 cases of schizophrenia, among which certain effect was achieved and about which the detail was collated and elaborated.

  9. Disseminated intravascular coagulation in acute monoblastic leukemia: response to heparin therapy.

    OpenAIRE

    Mangal, A K; Grossman, L.; Vickars, L.

    1984-01-01

    A 27-year-old man with acute monoblastic leukemia had clinical and laboratory evidence of disseminated intravascular coagulation (DIC), which was exacerbated by induction chemotherapy. Heparin therapy, adjusted according to the patient's clinical status and the results of coagulation studies, rapidly controlled the manifestations of DIC.

  10. Intravascular large B-cell lymphoma involving hemangiomas: an unusual presentation of a rare neoplasm.

    Science.gov (United States)

    Nixon, Brigitte K; Kussick, Steven J; Carlon, Michael J; Rubin, Brian P

    2005-08-01

    We report the clinicopathological features of two cases of intravascular large B-cell lymphoma involving cutaneous hemangiomas. The cases were identified from the consultation files of two of the authors. Both patients were women, 64 and 55 years of age, who presented with long-standing cutaneous hemangiomas of the posterior scalp and left shoulder, respectively. The lesions were brought to medical attention by an increase in size and change in color. Biopsies and immunohistochemical evaluation of the hemangiomas revealed extensive involvement by intravascular large B-cell lymphoma. The neoplastic cells were diffusely positive for CD20 in both cases and negative for CD3, pan-cytokeratin (AE1/AE3), epithelial membrane antigen, S-100, Factor VIII-related antigen, CD34 and CD31. Disease was limited to the hemangiomas in both patients. Treatment consisted of chemotherapy (both patients) and adjuvant radiation therapy (one patient). One patient had a recurrence of disease 33 months after initial diagnosis, leading to an autologous stem cell transplant. The other patient is without evidence of disease 27 months after initial diagnosis. Although this is a rare neoplasm, it is important to consider intravascular large B-cell lymphoma in the differential diagnosis of vascular lesions containing intravascular neoplastic cells. PMID:15803190

  11. Consensus standards for acquisition, measurement, and reporting of intravascular optical coherence tomography studies

    DEFF Research Database (Denmark)

    Tearney, Guillermo J; Regar, Evelyn; Akasaka, Takashi; Adriaenssens, Tom; Barlis, Peter; Bezerra, Hiram G; Bouma, Brett; Bruining, Nico; Cho, Jin-Man; Chowdhary, Saqib; Costa, Marco A; de Silva, Ranil; Dijkstra, Jouke; Di Mario, Carlo; Dudeck, Darius; Falk, Erling; Feldman, Marc D; Fitzgerald, Peter; Garcia, Hector Hernan Caro; Gonzalo, Nieves; Granada, Juan F; Guagliumi, Giulio; Holm, Niels Ramsing; Honda, Yasuhiro; Ikeno, Fumiaki; Kawasaki, Masanori; Kochman, Janusz; Koltowski, Lukasz; Kubo, Takashi; Kume, Teruyoshi; Kyono, Hiroyuki; Lam, Cheung Chi Simon; Lamouche, Guy; Lee, David P; Leon, Martin B; Maehara, Akiko; Manfrini, Olivia; Mintz, Gary S; Mizuno, Kyiouchi; Morel, Marie-Angéle; Nadkarni, Seemantini; Okura, Hiroyuki; Otake, Hiromasa; Pietrasik, Arkadiusz; Prati, Francesco; Räber, Lorenz; Radu, Maria D; Rieber, Johannes; Riga, Maria; Rollins, Andrew; Rosenberg, Mireille; Sirbu, Vasile; Serruys, Patrick W J C; Shimada, Kenei; Shinke, Toshiro; Shite, Junya; Siegel, Eliot; Sonada, Shinjo; Suter, Melissa; Takarada, Shigeho; Tanaka, Atsushi; Terashima, Mitsuyasu; Troels, Thim; Uemura, Shiro; Ughi, Giovanni J; van Beusekom, Heleen M M; van der Steen, Antonius F W; van Es, Gerrit-Ann; van Soest, Gijs; Virmani, Renu; Waxman, Sergio; Weissman, Neil J; Weisz, Giora

    2012-01-01

    The purpose of this document is to make the output of the International Working Group for Intravascular Optical Coherence Tomography (IWG-IVOCT) Standardization and Validation available to medical and scientific communities, through a peer-reviewed publication, in the interest of improving the...

  12. 21 CFR 880.5965 - Subcutaneous, implanted, intravascular infusion port and catheter.

    Science.gov (United States)

    2010-04-01

    ... port and catheter. 880.5965 Section 880.5965 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... port and catheter. (a) Identification. A subcutaneous, implanted, intravascular infusion port and catheter is a device that consists of a subcutaneous, implanted reservoir that connects to a...

  13. Effects of Hirudotherapy on Intravascular Thrombosis Activation in Different Cerebrovascular Pathologies

    Directory of Open Access Journals (Sweden)

    Oleg D. Barnaulov

    2010-09-01

    Full Text Available In spite of a wide range of antithrombotic agents, the common antiaggregants are not always effective in the clinical practice. In the available literature there are no clinical data on the eff ects of leech secretion on intravascular thrombosis activation process and the eff ectiveness of hirudotherapy in patients with cerebrovascular pathologies. 53 patients with cerebrovascular diseases (chronic vertebrobasilar insufficiency, ischemic encephalopathy stage I, previous ischemic stroke, and hemodynamically signifi cant stenosis and/or occlusion of the internal carotid artery received 10 sessions of hirudotherapy. Morphological and functional thrombosis assessment by phase contrast microscope was carried out twice: before and after the course of hirudotherapy. Baseline thrombocyte activation was increased in 52 of 53 patients in our study. More signifi cantly increased intravascular thrombocyte activation was observed in the group of patients with a history of ischemic stroke. The course of hirudotherapy normalized most of the pathological changes of intravascular thrombocyte activation in 44 of 52 patients. Hirudotherapy seems an efficient method for correcting pathological changes of intravascular thrombocyte activation that does not dependon the severity of the disease and ischemic stroke.

  14. Genome Sequence of Stenotrophomonas maltophilia Strain AU12-09, Isolated from an Intravascular Catheter

    OpenAIRE

    Zhang, Li; Morrison, Mark; Ó Cuív, Páraic; Evans, Paul; Claire M. Rickard

    2013-01-01

    Stenotrophomonas maltophilia is an opportunistic nosocomial pathogen that is characterized by its high-level intrinsic resistance to a variety of antibiotics and its ability to form biofilms. Here, we report the draft genome sequence of Stenotrophomonas maltophilia AU12-09, isolated from an intravascular catheter tip.

  15. Intravascular hemolysis induced by Lonomia obliqua caterpillar bristle extract: an experimental model of envenomation in rats.

    Science.gov (United States)

    Seibert, Carla Simone; Oliveira, Mara Regina L; Gonçalves, Luís Roberto C; Santoro, Marcelo Larami; Sano-Martins, Ida Sigueko

    2004-12-01

    Hemostatic disturbances are frequent findings in human accidents caused by Lonomia obliqua caterpillars in the southern region of Brazil. In severe envenomation, patients may present life-threatening bleedings. Such disturbances may be mimicked in rats, which also develop intravascular hemolysis. The scope of this study was to investigate the time-course and intensity of intravascular hemolysis induced by i.d. injection of 750 microg/kg crude L. obliqua bristle extract in rats. Total blood cell count, reticulocyte count, plasma hemoglobin and haptoglobin assays were performed in control and envenomed rats at 1, 6, 24 and 48 h after envenomation. Rats presented a drastic drop of haptoglobin levels at 1 and 6h with increased plasma hemoglobin levels, a decrease in packed cell volume values at 6, 24 and 48 h, and increased reticulocyte counts throughout after envenomation. Such observations indicated that intravascular hemolysis occurred as early as 1h following envenomation, and lasted for more than 6h. Intravascular hemolysis is probably induced by phospholipase A(2) and other proteins with direct hemolytic activity present in crude caterpillar bristle extract. PMID:15500855

  16. Lung and renal uptake of techneticum Tc 99m sulphur colloid related to disseminated intravascular coagulation

    Energy Technology Data Exchange (ETDEWEB)

    Jelle Teertstra, H.; Verdegaal, W.P.; Ras, G.J.

    1985-01-01

    In addition to a recently published case study, we present another three cases in which we observed both lung and renal uptake of technetium Tc 99m sulphur colloid which was related to a period of disseminated intravascular coagulation. Being familiar with this relationship may influence the diagnosis and course of the illness in certain patients.

  17. Lung and renal uptake of techneticum Tc 99m sulphur colloid related to disseminated intravascular coagulation

    International Nuclear Information System (INIS)

    In addition to a recently published case study, we present another three cases in which we observed both lung and renal uptake of technetium Tc 99m sulphur colloid which was related to a period of disseminated intravascular coagulation. Being familiar with this relationship may influence the diagnosis and course of the illness in certain patients. (orig.)

  18. Disseminated intravascular coagulation or acute coagulopathy of trauma shock early after trauma? A prospective observational study

    DEFF Research Database (Denmark)

    Johansson, Per Ingemar; Sorensen, Anne Marie; Perner, Anders; Welling, Karen-Lise; Wanscher, Michael; Larsen, Claus F; Ostrowski, Sisse R

    2011-01-01

    ABSTRACT: INTRODUCTION: It is debated whether the early trauma induced coagulopathy (TIC) in severely injured patients reflects disseminated intravascular coagulation (DIC) with a fibrinolytic phenotype, acute coagulopathy of trauma shock (ACoTS) or yet other entities. This study investigated the...

  19. Comparison of external and intravascular cooling to induce hypothermia in patients after CPR

    Directory of Open Access Journals (Sweden)

    Strasser, Ruth H.

    2006-06-01

    Full Text Available Objective: Hypothermia has been shown to reduce neurologic deficits in patients after cardiopulmonary resuscitation (CPR. It was not clear if intravascular cooling is superior to standard external cooling in inducing hypothermia. Goal of this study was to compare intravascular cooling with an automated cooling device with external cooling in everyday practice on a cardiac-care ICU (intensive care unit. Methods: Patients after successful CPR for unwitnessed cardiac arrest were subjected to cooling with an automated cooling system (CoolGard, Alsius after initial hemodynamic stabilization. Goal was to achieve a core temperature of 33°C. Monitored were the time intervals from admission to begin of cooling and from begin of cooling to target temperature. Data were compared retrospectively with those from patients subjected to external cooling. Results: 31 consecutive patients treated with intravascular cooling were analyzed. Cooling was initiated at a mean time of 58 min after admission, and the target temperature of 33°C was achieved after a mean of 3.48 hours after the begin of cooling. In contrast, 49 patients treated with external cooling achieved a minimum temperature of 34.8°C only 9.2 hours after admission. Conclusion: In everyday practice, intravascular cooling using an automated cooling system is superior for a rapid induction of hypothermia after cardiac arrest.

  20. Linfoma não-Hodgkin na infância: características clínico-epidemiológicas e avaliação de sobrevida em um único centro no Nordeste do Brasil Non-Hodgkin's lymphoma in childhood: clinical and epidemiological characteristics and survival analysis at a single center in Northeast Brazil

    OpenAIRE

    Márcia Ferreira Pedrosa; Francisco Pedrosa; Mecneide M. Lins; Nicodemos T. Pontes Neto; Gilliatt Hanois Falbo

    2007-01-01

    OBJETIVO: Descrever o perfil clínico-epidemiológico dos pacientes portadores de linfoma não-Hodgkin diagnosticados no Serviço de Oncologia Pediátrica do Instituto Materno-Infantil Professor Fernando Figueira em um período de 9 anos, bem como descrever sobrevida e possíveis associações prognósticas com as variáveis clínico-epidemiológicas estudadas. MÉTODOS: Estudo descritivo de corte transversal, realizado através da análise dos prontuários de 110 pacientes com linfoma não-Hodgkin admitidos n...

  1. An unusual case of an ulcerative colitis flare resulting in disseminated intravascular coagulopathy and a bladder hematoma: a case report

    Directory of Open Access Journals (Sweden)

    Christie Dennis

    2004-10-01

    Full Text Available Abstract Background Disorders of coagulation have long been associated with inflammatory bowel disease. Children, as well as adults, with both active and inactive ulcerative colitis have been found to have abnormal coagulation and fibrinolysis. Disseminated intravascular coagulation arises from an overwhelming of the haemostatic regulatory mechanisms leading to an excessive generation of thrombin and a failure of the normal inhibitory pathways to prevent systemic effects of this enzyme. Ulcerative colitis has been associated with disseminated intravascular coagulation in conjunction with septicemia, toxic megacolon and surgery. Case presentation A fourteen-year-old boy with a history of poorly controlled ulcerative colitis presented with nonbilious emesis, hematochezia, and hematuria. Laboratory workup revealed disseminated intravascular coagulation. He was placed on triple antibiotics therapy. An infectious workup came back negative. A computerized tomography (CT scan of the abdomen revealed a marked thickening and irregularity of the bladder wall as well as wall thickening of the rectosigmoid, ascending, transverse, and descending colon. Patient's clinical status remained stable despite a worsening of laboratory values associated with disseminated intravascular coagulation. Patient was begun on high dose intravenous steroids with improvement of the disseminated intravascular coagulation laboratory values within 12 hours and resolution of disseminated intravascular coagulopathy within 4 days. A thorough infectious workup revealed no other causes to his disseminated intravascular coagulation. Conclusions The spectrum of hypercoagulable states associated with ulcerative colitis varies from mild to severe. Although disseminated intravascular coagulation associated with ulcerative colitis is usually related to septicemia, toxic megacolon or surgery, we present a case of an ulcerative colitis flare resulting in disseminated intravascular coagulation and a bladder hematoma.

  2. COAGULACIÓN INTRAVASCULAR DISEMINADA SECUNDARIA A ANEURISMA AÓRTICO DIAGNOSTICADA TRAS EXTRACCIÓN DENTAL

    OpenAIRE

    Cuevas-Ruiz MV; De la Nogal B; Cuevas-Ruiz B

    2006-01-01

    RESUMEN:Las manifestaciones de la coagulación intravascular diseminada (CID) están determinadas por la causa subyacente; sin embargo, en los casos de CID compensada el diagnóstico se basa en las pruebas de laboratorio.Presentamos el caso de un varón de 81 años al que se diagnostico de una coagulación intravascular diseminada secundaria a un aneurisma gigante de ambas ilíacas tras una extracción dentaria. SUMMARYThe clinical presentation of disseminated intravascular coagulopathy (DIC) is dete...

  3. Avances y perspectivas del aprovechamiento del tratado de libre comercio con Estados Unidos

    Directory of Open Access Journals (Sweden)

    Hernando José Gómez

    2013-08-01

    Full Text Available En este artículo se hace una revisión de las oportunidades y los retos de exportación frente al Tratado de Libre Comercio (TLC con Estados Unidos. Asimismo, se traza un análisis de las necesidades transversales de los sectores de la economía incluyendo temas sanitarios, fitosanitarios y de calidad. De igual manera, se destaca la importancia de robustecer la industria nacional en términos de competitividad del sector agrícola y ganadero, confecciones, servicios en salud, metalmecánica, agroindustria, entre otros, de la mano de acciones logísticas y estrategias de innovación para lograr la eficiencia y aprovechamiento del tratado bilateral.

  4. Cortisol sérico de equinos com compactação experimental no cólon maior tratados com hidratações enteral e parenteral

    Directory of Open Access Journals (Sweden)

    José Dantas Ribeiro Filho

    2011-06-01

    Full Text Available O cortisol sérico foi estudado em equinos com compactação experimental do cólon maior tratados com fluidoterapias enteral (EN e intravenosa (IV. Utilizaram-se 10 animais separados em dois grupos de cinco cada. Os animais eram portadores de compactação induzida no cólon maior. O grupo EN foi tratado com solução isotônica poliônica enteral (8 mL/kg/h/48 h, enquanto o grupo IV recebeu Ringer lactato (16 mL/kg/h/12 h, durante dois dias. A compactação do cólon maior ocasionou aumento (P < 0,05 nos valores do cortisol nos animais de ambos os grupos. As soluções utilizadas no tratamento da compactação, fluidoterapia enteral com solução isotônica poliônica (EN e fluidoterapia intravenosa com solução de Ringer lactato (IV, foram eficientes na redução dos valores do cortisol sérico em equinos com compactação induzida no cólon maior.

  5. A ORGANIZAÇÃO POLÍTICA NO SÉCULO XIV SEGUNDO O "TRATADO SOBRE A MOEDA" DE NICOLE ORESME

    Scientific Electronic Library Online (English)

    Sueli Sampaio Damin, Custódio.

    2015-06-01

    Full Text Available Este artigo mostra como Oresme orienta o leitor do "Tratado" a pensar a organização da vida política no processo histórico do século XIV a partir do estudo sobre a alteração da moeda. [...] Abstract in english This paper shows how Oresme guides the reader of his "Treatise" to a thought in order to connect the organization of political life in the historical process of the 14th Century based on the study on the change in money. [...

  6. Abscesso cerebelar tratado clinicamente: relato de caso Cerebellar abscess treated by clinical management: case report

    OpenAIRE

    Josué Guimarães Granha Vialogo; Maria Cristina Arrua Sanches

    2001-01-01

    Apresentamos um caso de abscesso cerebelar secundário a otite média crônica, localizado no hemisfério cerebelar direito, em uma paciente pediátrica, que foi tratado clinicamente. Obtendo resolução sem necessidade de cirurgia. A antibioticoterapia foi escolhida segundo critérios da literatura para os agentes etiológicos mais prováveis. Discutimos a patogênese, histopatogênese, o quadro clínico, o diagnóstico e as formas de tratamento dos abscessos do sistema nervoso central.We report a case of...

  7. Aceros sinterizados tratados al vapor para la fabricación de componentes de amortiguadores bitubo

    Directory of Open Access Journals (Sweden)

    Cambronero, L. E. G.

    2000-06-01

    Full Text Available In this work, properties of three sintered and steam treated alloyed irons were analysed. These materials were Fe+2Cu, Fe+0.6C+0.5Cu, and Fe+0.45P+2.5Cu, which were obtained by powder mixing. Once pressed and sintered, samples were steam treated (surface treatment which is characteristic of sintered irons. Density, hardness and tensile strength were obtained on sintered and steam treated samples, within their microstructure analysis. Also, a tribological study was carried out since some parts of shock absorbers are working under friction.

    En este trabajo se analizan las propiedades de tres hierros aleados sintetizados y tratados al vapor. Los materiales seleccionados son el Fe+2Cu, Fe+0.6C+0.5Cu, y Fe+0.45P+2.5Cu, obtenidos por mezcla elemental de polvos. Una vez compactados y sintetizados, se sometieron a un tratamiento de recubrimiento característico de los hierros, como es el tratamiento al vapor. En los materiales sintetizados y tratados al vapor, se determinaron su densidad, dureza y resistencia a tracción, junto con su análisis microestructural. Así mismo dado que algunos de los componentes de los amortiguadores bitubo están sometidos a esfuerzos de fricción, se analizaron el comportamiento tribologíco de los materiales obtenidos tanto en estado sintetizado como tratados al vapor.

  8. Organizaciones internacionales y tratados asociativos: por una nueva clasificación de los sujetos de derecho internacional

    Directory of Open Access Journals (Sweden)

    Raphael Carvalho de Vasconcelos

    2015-08-01

    Full Text Available La personalidad jurídica es elemento fundamental para la actuación de un sujeto en el orden internacional. La efectiva participación en el espacio global no depende, sin embargo, sólo del cumplimiento de este requisito. Doctrina y jurisprudencia reconocen la personificación de las organizaciones internacionales actualmente sin grandes reservas, pero, ¿correspondería entender que cualquier tratado dotado de personería jurídica debe ser considerado investido de poderes para actuar en el orden internacional muchas veces de forma pareja a los estados? Se propone, en este breve estudio, identificar la existencia de un sistema de solución de diferencias institucionalizado como un requisito necesario para la actuación de las referidas estructuras como sujetos de derecho internacional estableciendo criterios capaces de distinguir las organizaciones internacionales de meros tratados asociativos. En la primera parte, son establecidos los contenidos de conceptos como personalidad y capacidad y, en seguida, el pronunciamiento de la Corte Internacional de Justicia que reconoció la personería jurídica internacional de las Naciones Unidas contribuye al avance de la construcción teórica sugerida. En la tercera parte, las perspectivas interna e internacional son contrapuestas e introducen el siguiente debate, que fija las bases de la separación entre los conceptos de organización internacional y de tratados asociativos. Para fundamentar la diferenciación señalada, se propone, entonces, el reconocimiento de la importancia de los sistemas institucionalizados de solución de controversias como requisito que avale la propuesta de una nueva clasificación de los sujetos de derecho internacional.

  9. Acantosis nigricans y linfoma no Hodgkin: presentación de un caso / Acanthosis nigricans and non-Hodgkin’s lymphoma: a case presentation

    Scientific Electronic Library Online (English)

    Miguel Damián, Junco Bonet; José Ignácio, Larquin Comet.

    2014-04-01

    Full Text Available Fundamento: la acantosis nigricans fue la primera dermatosis en la que se reconoció un carácter paraneoplásico. La característica sobresaliente es la hiperpigmentación simétrica y el engrosamiento aterciopelado de la piel. Se sugiere que algún factor producido por el tumor estimula el crecimiento ep [...] idérmico. Objetivo: presentar un caso poco frecuente de un paciente con el diagnóstico de linfoma no Hodgkin y acantosis nigricans. Caso clínico: se presenta el caso de un paciente masculino de 62 años de edad con antecedentes de hipertensión arterial que un año previo a su ingreso manifestó cambios en la coloración de la piel, dermatosis generalizada, hiperpigmentación e hiperqueratosis en las palmas de las manos y el cuello. Conclusiones: el tumor más frecuente asociado con acantosis es el adenocarcinoma abdominal en 90 % de los casos, entre los cuales 64 a 69 % son de origen gástrico; el resto (10 %) se asocian con cáncer no digestivo; linfoma de Hodgkin, micosis fungoide, cáncer de esófago, próstata y tiroides. En el linfoma no Hodgkin su asociación es considerada muy rara y son pocos los casos reportados en la bibliografía. Abstract in english Background: acanthosis nigricans was the first dermatosis in which a paraneoplastic nature was identified. The most significant feature is symmetrical hyperpigmentation and velvety thickening of the skin. It is suggested that any factor produced by the tumor stimulates the epidermal growth. Objectiv [...] e: to present the infrequent case of a patient diagnosed with non-Hodgkin’s lymphoma and acanthosis nigricans. Clinical case: the case of a sixty-two-year-old male patient with a personal history of high blood pressure is presented. A year before his admission the patient presented changes in the coloration of the skin, widespread dermatosis, hyperpigmentation and hyperkeratosis in the hands and neck. Conclusions: the most frequent tumor associated to acanthosis was abdominal adenocarcinoma, found in the 90 % of the cases; among them a 64 to 69 % were of gastric origin; the rest of the cases (10 %) were associated to non-digestive cancer, Hodgkin’s lymphoma, mycosis fungoides, esophagus cancer, prostate cancer, and thyroid cancer. In relation to Hodgkin’s lymphoma, the association is considered as rare, and there are just a few cases reported in the bibliography.

  10. Concomitant thyroid Malt lymphoma and papillary thyroid carcinoma Concomitância de linfoma MALT de tireoide e carcinoma papilífero de tireoide

    Directory of Open Access Journals (Sweden)

    Giulianno Molina de Melo

    2010-06-01

    Full Text Available The objective of this study was to describe the rare thyroid MALT lymphoma concomitant with papillary thyroid carcinoma in a male patient who was submitted to total thyroidectomy. Treatment and follow-up issues are addressed. Male patient complains of fast thyroid enlargement without lymphadenophaty and normal clinical exams. Total thyroidectomy was indicated and performed without any complications. The pathology showed multicentric papillary thyroid carcinoma, concomitant thyroid MALT lymphoma and Hashimoto's thyroiditis. The immunohistochemistry assay was positive for CD 20, CD 43, CD 79, AE1/AE3. The staging studies showed no evidence of both metastasis, Ann Harbor stage IE, without B symptoms. After RIT no further radiotherapy or chemotherapy was indicated. Nowadays the thyroglobulin is undetectable, without recurrences at two years of follow-up. It was concluded that primary thyroid MALT lymphoma is uncommon being the papillary thyroid carcinoma more frequent. Both occurring concomitantly is very rare and the treatment has to prioritize the tumor of worst prognosis at the discovery moment.O objetivo deste trabalho foi descrever um raro linfoma MALT primário de tireoide concomitante com carcinoma papilífero em paciente masculino submetido à tireoidectomia total. O tratamento e o seguimento são discutidos no texto. Paciente masculino com rápido aumento da tireoide sem linfonodomegalias com exames normais. A tireoidectomia total foi indicada e realizada sem complicações. O anatomopatológico mostrou carcinoma papilífero multicêntrico concomitante com linfoma MALT e tireoidite de Hashimoto. A imuno-histoquímica foi positiva para CD 20, CD 43, CD 79, AE1/AE3. O estadiamento clínico não demonstrou evidência de metástases de ambos, Ann Harbor estádio IE, sem sintomas B. Realizado RIT sem radioterapia ou quimioterapia. Atualmente se encontra com tireoglobulina indetectável, sem recidivas ao seguimento de dois anos. Concluiu-se que o linfoma MALT primário de tireoide é raro e o carcinoma papilífero é o mais frequente com boa evolução. A concomitância de ambos é muito rara e o tratamento deve priorizar a neoplasia que apresenta o pior prognóstico no momento da descoberta.

  11. Linfoma difuso primario de hígado: Presentación de un caso Diffuse primary hepatic lymphoma: Case report

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    Silvana I. Romero Vidomlansky

    2011-06-01

    Full Text Available El linfoma primario de hígado (LPH es un tumor raro y representa menos del 1% de los linfomas no Hodgkin extranodales de células B. Se reporta un caso de LPH en un paciente de sexo masculino de 32 años de edad, sin enfermedad hepática crónica, que ingresa a nuestra institución por sospecha de síndrome mononucleósico. La serología para Virus Epstein Barr fue positiva. Se observó mediante ecografía hepatoesplenomegalia con parénquima hepático heterogéneo en forma difusa. La RM demostró hepatoesplenomegalia y alteraciones en lóbulo derecho hepático, compatibles con infiltración linfoproliferativa. Se realizó biopsia hepática con guía ecográfica y el estudio histopatológico reveló un linfoma no Hodgkin difuso de células grandes con inmunofenotipo B. Se presentan las características clínicas y patológicas del caso, así como una revisión de los aspectos clínicos, hallazgos patológicos y radiológicos.Primary hepatic lymphoma (PHL is a rare tumor that represents less than 1% of extranodal non-Hodgkin B-cell lymphoma. We report a case of PHL in a 32 year-old male patient without chronic liver disease, who was admitted into our institution for suspected mononucleosis syndrome. Serology for Epstein-Barr virus was positive. Ultrasound revealed hepatosplenomegaly with diffuse heterogeneous liver parenchyma. The MRI showed hepatosplenomegaly and alterations in the right lobe of the liver compatible with lymphoproliferative infiltration. Liver biopsy was performed under ultrasound guidance, and histopathologic examination revealed a diffuse non-Hodgkin lymphoma of large cells with immunophenotype B. A clinical and a pathological case as well as a review of the clinical, pathological and radiological findings of this disease are presented.

  12. Micose fungoide: relato de caso tratado com radioterapia Mycosis fungoides: case report treated with radiotherapy

    Directory of Open Access Journals (Sweden)

    Gustavo Nader Marta

    2011-06-01

    Full Text Available Micose fungoide é um tipo de linfoma não Hodgkin de células T raro que acomete primariamente a pele. Caracteriza-se pela presença de placas eritematosas que evoluem para lesões ulceradas, tumores em toda a pele ou ainda infiltração de medula óssea em estágios avançados. Como opção de tratamento para os casos iniciais, tem-se quimioterapia e corticoterapia tópica, fototerapia e radioterapia. Este estudo relata o caso de um doente com múltiplas lesões tumorais na pele já biopsiadas com diagnóstico de micose fungoide. O paciente foi refratário ao tratamento com quimioterapia tópica e fototerapia, sendo então indicada irradiação total da pele com elétronsMycosis fungoides is a rare type of non-Hodgkin's lymphoma of T cells that primarily affects the skin. It is characterized by the presence of erythematous plaques that evolve into ulcerated lesions, tumors throughout the skin or even bone marrow infiltration in advanced stages. Chemotherapy and topical steroids, phototherapy and radiotherapy are treatment options for early cases. This study reports the case of patient with multiple tumor lesions in the skin already biopsied with diagnosis of mycosis fungoides. The patient was refractory to both treatments with topical chemotherapy and phototherapy. It was then indicated total skin irradiation with electrons

  13. Interacción de los efectos del policosanol y el aceite de pescado sobre el tiempo de sangrado y la agregación plaquetaria intravascular en ratas

    Directory of Open Access Journals (Sweden)

    Vivian Molina

    2009-01-01

    Full Text Available El consumo de aceite de pescado ha mostrado reducir los eventos cardiovasculares por lo cual investigar si su administración con terapias concomitantes aporta beneficios adicionales resulta de interés. Estudios experimentales y clínicos han mostrado que la administración conjunta de aceite de pescado y policosanol muestra beneficios añadidos sobre el perfil lipídico y la agregación plaquetaria inducida ex vivo. Este trabajo investigó si la terapia combinada aceite de pescado + policosanol mostraba evidencias de interacción farmacológica sobre el tiempo de sangrado (TS y la agregación plaquetaria intravascular inducida in vivo en ratas. Las ratas se distribuyeron en siete grupos: uno control negativo tratado con vehículo al que no se le inyectó colágeno y seis grupos con agregación inducida por colágeno, uno tratado con vehículo (control positivo, uno con aceite de pescado (1 g/kg, dos tratados con policosanol (5 ó 25 mg/kg y dos con aceite de pescado (1 g/kg + policosanol (5 ó 25 mg/kg. Los tratamientos se administraron por vía oral durante cuatro semanas, al término de las cuales se determinó el TS y la agregación plaquetaria in vivo. El policosanol, el aceite de pescado y la terapia combinada inhibieron la agregación plaquetaria por colágeno, pero la terapia combinada no produjo efectos mayores que las monoterapias. Ninguna monoterapia modificó significativamente el TS, si bien la terapia combinada aumentó esta variable en una magnitud sugestiva de interacción aditiva. No se observaron manifestaciones hemorrágicas en las ratas tratadas con la terapia combinada, lo que sugiere un bajo riesgo potencial en este sentido.

  14. Accurate monitoring of intravascular fluid volume: A novel application of intrathoracic impedance measures for the guidance of volume reduction therapy

    Directory of Open Access Journals (Sweden)

    Barbara A. Lara

    2015-09-01

    Conclusion: Impedance vectors derived from a multivector monitoring system reflect changes in intravascular plasma volume. Two of these vectors most closely track changes in plasma volume and may be used to more accurately guide and optimize volume reduction therapy.

  15. Intravascular heat exchange technology successfully treats a patient after ultra-long cardiopulmonary resuscitation: a case report

    OpenAIRE

    Zou, Xiuli; Wu, Tiejun; Zhang, Lina; Zhang, Xihong; Tian, Hui

    2015-01-01

    Objective: To investigate the effect of intravascular heat exchange in saving the lives of patients after cardiopulmonary resuscitation. Methods: The clinical data of a female patient who was given cardiopulmonary resuscitation for 1.67 h in July 2014 in our hospital was retrospectively analyzed. An intravascular heat exchange procedure was performed on the patient to control her body temperature. Comprehensive treatment measures also included mechanical ventilation, vasoactive agents, and os...

  16. Linfoma subcutâneo de células T paniculite-símile Subcutaneous panniculitis-like T-cell lymphoma

    OpenAIRE

    Renato Soriani Paschoal; Renata Nahas Cardilli; Darlene Arruda; Belinda Pinto Simões; Cacilda da Silva Souza

    2009-01-01

    Linfoma subcutâneo de células T paniculite-símile foi recentemente reconhecido como entidade clínico-patológica. Paciente do sexo feminino, 17 anos, relatou nodosidades eritêmato-violáceas e depressões nos membros e abdome há três anos e discreta perda ponderal, sem outros sintomas gerais. Adenomegalia, visceromegalias e infiltração da medula óssea estavam ausentes, e a histopatologia da pele mostrou densa infiltração de linfócitos atípicos CD3/CD8 no subcutâneo. A quimioterapia interrompeu o...

  17. Endoscopic staging of low-grade gastric malt lymphoma Estadificación por ecoendoscopia en el linfoma gástrico tipo malt de bajo grado

    Directory of Open Access Journals (Sweden)

    M. J. Varas

    2006-03-01

    Full Text Available Introduction: endoscopic ultrasonography (EUS has already proven useful in the assessment of submucosal lesions, and the staging of gastrointestinal cancer, particularly gastric MALT-type lymphoma. The goal of this paper was EUS staging. Patients and method: 24 patients (10 females, 14 males with a median age of 56 years and possibly gastric MALT lymphoma (25 cases were studied using videoendoscopy, biopsies, and echoendoscopy with 7.5- and 20-MHz radial EUS, and also with 12- and 20-MHz miniprobes (MPs. Nineteen patients were definitely evaluated (7 females, 12 males as having 20 MALT-type lymphomas, as five patients were post-hoc disregarded when an invasive, high-grade gastric lymphoma (3c or plasmocytoma (2c was subsequently demonstrated. Of these 19 patients, all had T1 lesions except for two with T2 lesions; one patient had a gastroduodenal T1 lymphoma. Echographic findings with MPs were compared to EUS (gold standard and histology both before and after eradication. Then, patients were followed up every 1-3-6 months using videoendoscopy and MPs. Results: echoendoscopy correctly identified T stages in 90% of cases. MPs identified T stages in 88% of cases, and N stages in 33% of cases, with results being slightly inferior to those obtained with conventional EUS (91 vs. 45%; they were consequently used for follow-up. After eradication, all but two patients are in complete remission and have been followed every 1-3-6 months using MPs without echographic abnormalities, except for a patient who relapsed.Introducción: la ultrasonografía endoscópica (USE ha demostrado ya su utilidad en la evaluación de las lesiones submucosas, en la estadificación del cáncer digestivo en general, y del linfoma gástrico tipo MALT en particular. El objetivo de este trabajo fue la estadificación por USE. Pacientes y método: veinticuatro enfermos (10 mujeres y 14 varones con edad media de 56 años y con posible linfoma gástrico tipo MALT (25 casos fueron estudiados con videoendoscopia, biopsias y ecoendoscopia con USE radial de 7,5 y 20 MHz, y con minisondas (MS de 12 y 20 MHz. Se evaluaron definitivamente 19 pacientes (7 mujeres y 12 varones con 20 MALT, ya que cinco enfermos se desestimaron por demostrarse a posteriori que presentaban un linfoma gástrico invasivo de alto grado (3c o un plasmocitoma (2c. De los 19 pacientes todos eran T1 menos dos pacientes que eran T2, y otra presentaba un linfoma T1 gastroduodenal. Los hallazgos ecográficos de las MS fueron comparados con la USE (gold standard y con la histología antes y después de la erradicación. Después, fueron seguidos cada 1, 3 y 6 meses mediante videoendoscopia y MS. Resultados: la ecoendoscopia identificó el estadio T correcto en el 90% de los casos. Las MS identificaron el estadio T en el 88% de los casos y la N en el 33% de los casos, con resultados discretamente inferiores a los obtenidos con la USE convencional (91 y 45%, por lo que se utilizaron en el seguimiento. Después de la erradicación, todos menos dos están en remisión completa y han sido seguidos cada 1, 3 y 6 meses con las MS sin observar anomalías ecográficas, excepto una paciente que hizo una recidiva.

  18. Linfoma primário de células T no líquido cefalorraquidiano de cão: relato de caso

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    L.F. Moraes

    2012-12-01

    Full Text Available Relata-se o diagnóstico de linfoma primário no sistema nervoso central em um cão Labrador Retrievier, de 10 anos de idade, que apresentava episódios convulsivos, incoordenação nos membros posteriores, head tilt, ataxia e sensibilidade diminuída no lado esquerdo. Constataram-se alterações laterais esquerdas, como ausências de propriocepção e de posicionamento tátil, alterações posteriores nas provas de carrinho de mão e de reação ao pulo e diminuição da extensão da postura e hemilocomoção. No líquido cefalorraquidiano (LCR, houve predomínio de linfócitos atípicos, caracterizados pela presença de anisocitose e anisocariose, nucléolos evidentes e anisonucleose, basofilia e microvacuolização citoplasmáticas, mitoses atípicas e corpúsculos linfoglandulares, compatíveis com linfoma, confirmado pelo exame histológico e imunocitoquímico, o qual revelou origem T, com expressão CD3+ e CD79-. A tomografia computadorizada não foi conclusiva e evidenciou diversas áreas hipodensas e intensificação de contraste na região de sulcos e giros do parênquima encefálico. A coleta do LCR foi essencial na rapidez do diagnóstico definitivo, indicando a natureza rara desta lesão primária.

  19. "Tratado" e Exercício de ser criança: a infância entre versos, rimas e tintas / "Tratado" and Exercício de ser criança: childhood amid verses, rhymes and paints

    Scientific Electronic Library Online (English)

    Penha Lucilda de Souza, Silvestre; Alice Áurea Penteado, Martha.

    2015-12-01

    Full Text Available A obra de arte, de modo geral, consiste em um evento significativo, visto que o leitor pode vivenciar diferentes mundos ficcionais, como também recuperar e articular as redes intertextuais, no ato da leitura. Assim, há a possibilidade de repensar a sua própria experiência e as condições sociais em q [...] ue a criança está inserida. Nesse sentido, o nosso objetivo é realizar um percurso no universo poético, a partir da leitura dos textos Exercício de ser criança (1999), de Manoel de Barros, e Um pequeno tratado de brinquedos para meninos quietos (2009), de Selma Maria Kuasne, associando-os à produção plástica de Candido Portinari "Meninos soltando pipa" (de 1932), "Crianças brincando" (de 1938) e "Meninos brincando" (de 1955). Com efeito, essas obras nos permitem repensar como se dá a representação e a constituição da infância na arte e entendê-la nas tramas da poesia e da pintura, como também o ato de brincar, em um processo dialético. Abstract in english The work of art, in general, consists of a significant event, considering the reader can experience different fictional worlds, as well as retrieve and articulate the intertextual networks in the act of reading. Thus, there is the possibility of rethinking one's own experience as well as the social [...] conditions in which the child is inserted. In this sense, our objective is to perform a journey through the poetic universe from the reading of the texts Exercício de ser criança (1999), by Manoel de Barros, and Um pequeno tratado de brinquedos para meninos quietos (2009), by Selma Maria Kuasne, associating them to the paintings by Candido Portinari, 'Boys flying kites' (1932), 'Children playing' (1938) and 'Boys playing' (1955). Indeed, these pictures enable us to rethink how the representation and the constitution of childhood in art are conceived and to understand them in the weaving of poetry and painting, as well as the act of playing, in a dialectical process.

  20. Feasibility of in vivo intravascular photoacoustic imaging using integrated ultrasound and photoacoustic imaging catheter

    Science.gov (United States)

    Karpiouk, Andrei B.; Wang, Bo; Amirian, James; Smalling, Richard W.; Emelianov, Stanislav Y.

    2012-09-01

    Pilot studies of in vivo combined intravascular ultrasound (IVUS) and intravascular photoacoustic (IVPA) imaging are reported. A recently introduced prototype of an integrated IVUS/IVPA imaging catheter consisting of a single-element ultrasound transducer and a light delivery system based on a single optical fiber was adapted and used for in vivo imaging of a coronary stent deployed in a rabbit's thoracic aorta in the presence of luminal blood. The results suggest that in vivo IVUS/IVPA imaging is feasible using the integrated IVUS/IVPA imaging catheter. The challenges of in vivo combined IVUS/IVPA imaging are discussed, and further improvements on the design of the catheter and the clinical imaging system are proposed.

  1. Enhanced glucose tolerance by intravascularly administered piceatannol in freely moving healthy rats.

    Science.gov (United States)

    Oritani, Yukihiro; Okitsu, Teru; Nishimura, Eisaku; Sai, Masahiko; Ito, Tatsuhiko; Takeuchi, Shoji

    2016-02-12

    Piceatannol is a phytochemical in the seeds of passion fruit that has a hypoglycemic effect when orally administered. To elucidate the contribution of intact and metabolites of piceatannol after gastro-intestinal absorption to hypoglycemic effect, we examined the influence of piceatannol and isorhapontigenin on blood glucose concentrations during fasting and glucose tolerance tests by administering them intravascularly to freely moving healthy rats. We found that intravascularly administered piceatannol reduced the blood glucose concentrations during both fasting and glucose tolerance tests, but isorhapontigenin did not during either of them. Furthermore, we found that piceatannol increased the insulinogenic index during glucose tolerance tests and that piceatannol had no influence on insulin sensitivity by performing hyperinsulinemic euglycemic clamping tests. These results suggest that piceatannol orally intaken may enhance glucose tolerance by the effect of intact piceatannol through enhanced early-phase secretion of insulin. Therefore, oral intake of piceatannol might contribute to proper control of postprandial glycemic excursions in healthy subjects. PMID:26773506

  2. Neuroimágenes estructurales y funcionales en la caracterización del linfoma del SNC Structural and functional imaging for the characterization of CNS lymphomas

    Directory of Open Access Journals (Sweden)

    Cristina Besada

    2010-06-01

    Full Text Available Objetivo: Mostrar los hallazgos en imágenes del compromiso primario o secundario del Sistema Nervioso Central (SNC por el linfoma, haciendo énfasis en el aporte de la espectroscopía. Material y métodos: Se estudiaron en forma retrospectiva con un equipo de resonancia magnética (RM de 1.5T 25 casos (16 hombres y 9 mujeres con diagnóstico histológico de linfoma no Hodgkin y compromiso del SNC. Se destacaron los distintos tipos de presentación en imágenes convencionales con contraste y funcionales en espectroscopía. Se utilizaron técnicas multivoxel con tiempos de eco intermedio y corto. Resultados: Se detectaron 3 patrones principales de presentación de esta patología: parenquimatosa, meníngea y de pares craneanos. Además, se destacaron algunos hallazgos característicos, como compromiso de los espacios perivasculares. La resonancia magnética convencional no fue concluyente en la caracterización del tumor en varios de los casos. En dichos pacientes, el aporte de la espectroscopía fue de gran utilidad. El hallazgo más significativo tanto para los linfomas primarios como para los secundarios fue el aumento de los picos de lípidos y colina. El pico de lípido fue en algunos casos identificado como el metabolito dominante, especialmente en tiempos de eco (TE corto. No se encontraron diferencias en el patrón espectroscópico entre linfomas primarios y sistémicos. Conclusión: La afectación del SNC por los linfomas presenta una gran variedad de manifestaciones radiológicas, con diferentes patrones de presentación. Esta característica hace difícil la correcta caracterización de estos tumores en forma prequirúrgica sólo con RM convencional. La espectroscopía por RM puede ser de gran utilidad en estas situaciones, demostrando la presencia del pico de lípido. Este hallazgo, presente en un tumor sólido intraxial con realce post contraste sugiere la posibilidad de un linfoma y podría promover la modificación de la estrategia terapéutica y quirúrgica.Purpose: To show the imaging patterns of primary or secondary involvement of the Central Nervous System (CNS in cases of lymphoma with emphasis in the contribution of spectroscopy. Material and methods: 25 cases (16 males and 9 females were retrospectively reviewed using a 1.5T magnetic resonance unit. The patients had a histological diagnosis of Non- Hodgkins lymphoma with CNS involvement. The cases were studied with conventional MR with contrast and functional images were obtained with spectroscopy through a multivoxel technique using intermediate and short echo sequences Results: Three main patterns of presentation were identified: parenchymal, meningeal and cranial nerve involvement. Additionally some characteristic findings were detected such as the involvement of perivascular spaces. Conventional MRI was not conclusive in the characterization of several tumors. In such patients spectroscopy proved to be very useful. The most significant findings both in the primary tumors as well as in the secondary lesions were the lipid and choline peaks. The choline peak was in some cases identified as the dominant metabolite, particularly in the short TE echo sequences. No differences were found between the spectroscopic pattern of primary and systemic lymphomas. Conclusion: CNS lymphomas are tumors with a wide range of radiological patterns. This characteristic creates difficulties to characterize them correctly during the pre-surgical phase with conventional MRI alone. MR Spectroscopy may be useful in such cases by demonstrating the lipid peak. This finding only seen in deep intra-axial tumours demonstrated by contrast enhancement supports the presumption of lymphoma and may lead to changes in therapeutic or surgical strategy.

  3. Amniotic fluid embolism and disseminated intravascular coagulation complicating hypertonic saline-induced abortion.

    OpenAIRE

    Ballas, S.; Lessing, J B; Michowitz, M.

    1983-01-01

    Amniotic fluid embolism (AFE) associated with disseminated intravascular clotting (DIC) is usually fatal. Such a combination generally occurs at the term of pregnancy or in the immediate postpartum period. A case of AFE with DIC following a hypertonic-saline-induced abortion, is reported. The patient was in the midtrimester with a live fetus. Prompt recognition and treatment of her condition ensured her complete recovery. Such a case has not, to our knowledge, been previously reported.

  4. Distribution of [35S] taurine in mouse retina after intravitreal and intravascular injection

    International Nuclear Information System (INIS)

    The distribution of [35S] taurine in mouse retinae was studied by autoradiographic techniques after either intravitreal or intravascular injection. The route of injection did not affect the final localization. The major sites of label accumulation were the outer nuclear layer, the inner nuclear layer, and Mueller cell processes adjacent to the vitreal surface. The distribution was consistent with the interpretation that taurine was localized within two cellular compartments of mouse retina, photoreceptor cells and Mueller cells. (author)

  5. Destructive Radiologic Development of Intravascular Papillary Endothelial Hyperplasia on Skull Bone

    OpenAIRE

    Lee, Seul-Kee; Jung, tae-young; Baek, Hee-Jo; Kim, Seul-Kee

    2012-01-01

    Intravascular papillary endothelial hyperplasia (IPEH) is a rare vascular benign lesion that rarely involves the central nervous system with or without skull invasion. We report a rare case of IPEH on the skull bone, which displayed destructive radiologic development associated with hemorrhage. A 14-year-old male presented with an incidentally detected a small enhancing, left frontal osteolytic lesion. Previously, he underwent operation and received adjuvant chemoradiation therapy for cerebel...

  6. Intravascular Lymphomatosis Mimicking Primary Central Nervous System Lymphoma: A Case Report and Literature Review

    OpenAIRE

    Oomura, Masahiro; Sakakibara, Noriyuki; Suzuki, Shugo; Wakita, Atsushi; Mori, Yuji; Kamimoto, Kaoru

    2014-01-01

    We herein report a 75-year-old female patient with intravascular lymphomatosis (IVL) who presented with fever of unknown origin. Examination, including contrast-enhanced CT and 67Ga scintigraphy, failed to show any lesions. Her blood levels of lactate dehydrogenase and soluble interleukin-2 receptors were high, suggesting a lymphomatous tumor. A bone marrow puncture was negative, and a random skin biopsy revealed a monoclonal proliferation of naked, large lymphocytes in the vascular space of ...

  7. Colonization of bacteria on polyvinyl chloride and Teflon intravascular catheters in hospitalized patients.

    OpenAIRE

    Sheth, N. K.; Franson, T R; Rose, H D; Buckmire, F L; Cooper, J. A.; Sohnle, P G

    1983-01-01

    During an 8-month period all intravascular catheters were removed by sterile technique upon completion of use and submitted to the hospital microbiology laboratory. All catheters were routinely cultured by the semiquantitative culture technique, with greater than or equal to 15 colonies being defined as a positive result. Of the 687 Teflon catheters cultured, 6.9% were positive by culture, compared with 24.6% of 77 polyvinyl chloride catheters (P less than 0.001). Also, colonization of coagul...

  8. Colonization of peripheral intravascular catheters with biofilm producing microbes: Evaluation of risk factors

    OpenAIRE

    Monil Singhai; Abida Malik; Mohd.Shahid; Ashraf Malik; Vinita Rawat

    2012-01-01

    Background: Biofilms often colonize catheters and contribute to catheter-related septicemia. However, predictors of catheter colonization by biofilms remain poorly defined. The aim of this study was to evaluate clinical factors that may be associated with biofilm colonization of catheters. Materials and Methods: A total of 54 isolates colonizing the peripheral intravascular catheters (IVCs) were studied and their biofilm production ability was analyzed by the tube method and antimicrobial sus...

  9. Improvement and Automatic Classification of IVUS-VH (Intravascular Ultrasound – Virtual Histology) Images

    OpenAIRE

    Taki, Arash

    2010-01-01

    Heart attack and stroke are the major causes of human death and atherosclerotic plaques are the most common effect of cardiovascular disease. Intravascular ultrasound (IVUS), a diagnostic imaging technique, offers a unique view of the morphology of the arterial plaque displays the morphological and histological properties of a cross-section of the vessel. Limitations of the grayscale IVUS manual plaque assessment have led to the development of quantitative techniques for analysis of ...

  10. Double-cladding-fiber-based detection system for intravascular mapping of fluorescent molecular probes

    Science.gov (United States)

    Razansky, R. Nika; Rozental, Amir; Mueller, Mathias S.; Deliolanis, Nikolaos; Jaffer, Farouc A.; Koch, Alexander W.; Ntziachristos, Vasilis

    2011-03-01

    Early detection of high-risk coronary atherosclerosis remains an unmet clinical challenge. We have previously demonstrated a near-infrared fluorescence catheter system for two-dimensional intravascular detection of fluorescence molecular probes [1]. In this work we improve the system performance by introducing a novel high resolution sensor. The main challenge of the intravascular sensor is to provide a highly focused spot at an application relevant distance on one hand and a highly efficient collection of emitted light on the other. We suggest employing a double cladding optical fiber (DCF) in combination with focusing optics to provide a sensor with both highly focused excitation light and highly efficient fluorescent light collection. The excitation laser is coupled into the single mode core of DCF and guided through a focusing element and a right angle prism. The resulting side-fired beam exhibits a small spot diameter (50 ?m) throughout a distance of up to 2 mm from the sensor. This is the distance of interest for intravascular coronary imaging application, determined by an average human coronary artery diameter. At the blood vessel wall, an activatable fluorescence molecular probe is excited in the diseased lesions. Next light of slightly shifted wavelength emits only in the places of the inflammations, associated with dangerous plaques [2]. The emitted light is collected by the cladding of the DCF, with a large collection angle (NA=0.4). The doublecladding acts as multimodal fiber and guides the collected light to the photo detection elements. The sensor automatically rotates and pulled-back, while each scanned point is mapped according to the amount of detected fluorescent emission. The resulting map of fluorescence activity helps to associate the atherosclerotic plaques with the inflammation process. The presented detection system is a valuable tool in the intravascular plaque detection and can help to differentiate the atherosclerotic plaques based on their biological activity, identify the ones that prone to rupture and therefore require more medical attention.

  11. THROMBOPHILIA AND INTENSITY OF THE INTRAVASCULAR MICROCOAGULATION IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ATHEROTHROMBOSIS

    Directory of Open Access Journals (Sweden)

    E. A. Shelest

    2015-09-01

    Full Text Available Aim. To study the intensity of the intravascular microcoagulation in patients with atherothrombosis (AT, chronic obstructive pulmonary disease (COPD and thrombophilia.Material and methods. 115 patients were enrolled into the study: 37 patients with COPD (22 with thrombophilia and 15 without thrombophilia; 37 patients with AT (23 with thrombophilia and 14 without thrombophilia; 41 patients with COPD+AT (24 with thrombophilia and 17 without thrombophilia. In the control group 53 healthy people (39 with thrombophilia and 14 without thrombophilia were included. Median age was 62 (56.5, 69 years. The intensity of intravascular microcoagulation was measured: platelet factor 4 (PF4 by ELISA, D-dimer by ELISA, XIIa-dependent fibrinolysis (time. Polymerase chain reaction was used for detection of such trombophilia parameters as Leiden mutation, prothrombin gene mutation 20210A, mutation in the gene of methylenetetrahydrofolate reductase (MTHFR and plasminogen activator inhibitor-1 (PAI-1.Results. The level of PF4 and D-dimer was significantly higher while fibrinolytic activity was lower in COPD (103.5 ME/ml, 70 ng/ml, 650 s, respectively, AT (127.1 ME/ml, 96,9 ng/ml, 850 s, respectively and COPD+AT (136.5 ME/ml, 106.5 ng/ml, 1148 s, respectively groups as compared with the control group (p<0.05. When analyzing the level of intravascular coagulation parameters in patients with thrombophilia and without it, levels of PF4, D-dimer and XIIa-dependent fibrinolysis (time were significantly higher in thrombophilia subgroups among all patients (p<0.05. In patients with thrombophilia levels of these parameters were significantly higher in those with two or more thrombophilia gene polymorphisms than with one (p<0.01.Conclusion. The intensity of intravascular microcoagulation increases in patients with thrombophilia, atherothrombosis and COPD.

  12. Surgical management of Wilms tumor with intravascular extension: a single-institution experience.

    Science.gov (United States)

    Aspiazu, Diego; Fernandez-Pineda, Israel; Cabello, Rosa; Ramirez, Gema; Alvarez-Madrid, Antonio; De Agustin, Juan Carlos

    2012-02-01

    The purpose of this study was to retrospectively analyze the clinical presentation, treatment, and outcomes of children with Wilms tumor (WT) and intravascular extension who were treated at a single institution. A retrospective review was conducted of medical records of all children with Wilms tumor and intravascular extension treated at Virgen del Rocio Children's Hospital between 1992 and 2010. Seven patients (median age 3.4 years, range 2-8.1 years) were identified. At diagnosis, 6 of the 7 patients (85.7%) presented with tumor thrombus that reached the right atrium (RA) and 1 patient with infrahepatic inferior vena cava (IVC) thrombus. All patients received neoadjuvant chemotherapy (SIOP 2001 protocol) with vincristine, doxorubicin, and actinomycin D. Regression of the intravascular extension of the tumor was documented in all patients. Postchemotherapy level of extension was suprahepatic IVC in 1 patient, infrahepatic IVC in 2 patients, renal vein (RV) in 1 patient, and RA in 3 patients. Nephrectomy and thrombectomy were performed in all cases, requiring cardiopulmonary bypass for the 4 patients who presented with suprahepatic IVC and RA thrombus. The other 3 patients with infrahepatic IVC and RV involvement underwent cavotomy and thrombus extraction. Computed tomography, ultrasonography, and echocardiography were used for diagnosis and follow-up. All patients remain disease-free with a median follow-up of 6.3 years (range, 2-19 years). Neoadjuvant chemotherapy for WT with intravascular extension may facilitate the resection by decreasing the extent of the tumor thrombus. Cardiopulmonary bypass is indicated for suprahepatic IVC and RA involvement. Accurate diagnostic imaging is necessary. PMID:22304010

  13. MRI evaluation and follow-up of bone necrosis after meningococcal infection and disseminated intravascular coagulation

    International Nuclear Information System (INIS)

    Disseminated intravascular coagulation (DIC) is a serious complication of meningococcal septicaemia. It often results in infarction of various tissues namely the skin, adrenal glands, kidneys, brain and, much less commonly, bones. We describe a patient who presented bone lesions after meningococcal septicaemia. In addition to plain radiography and scintigraphy the lesions were evaluated with MRI and have proved to be extensive and still progressive, approxximately 18 months after the onset of the disease. (orig.)

  14. Automatic detection of bioresorbable vascular scaffold struts in intravascular optical coherence tomography pullback runs

    OpenAIRE

    Wang, Ancong; Nakatani, Shimpei; Eggermont, Jeroen; Onuma, Yoshi; Garcia-Garcia, Hector M.; Serruys, Patrick W.; Reiber, Johan H.C.; Dijkstra, Jouke

    2014-01-01

    Bioresorbable vascular scaffolds (BVS) have gained significant interest in both the technical and clinical communities as a possible alternative to metallic stents. For accurate BVS analysis, intravascular optical coherence tomography (IVOCT) is currently the most suitable imaging technique due to its high resolution and the translucency of polymeric BVS struts for near infrared light. However, given the large number of struts in an IVOCT pullback run, quantitative analysis is only feasible w...

  15. Insights into the pathogenesis of vein graft disease: lessons from intravascular ultrasound

    OpenAIRE

    Angelini Gianni D.; Murphy Gavin J

    2004-01-01

    Abstract The success of coronary artery bypass grafting (CABG) is limited by poor long-term graft patency. Saphenous vein is used in the vast majority of CABG operations, although 15% are occluded at one year with as many as 50% occluded at 10 years due to progressive graft atherosclerosis. Intravascular ultrasound (IVUS) has greatly increased our understanding of this process. IVUS studies have shown that early wall thickening and adaptive remodeling of vein grafts occurs within the first fe...

  16. High frame-rate intravascular optical frequency-domain imaging in vivo

    OpenAIRE

    Cho, Han Saem; Jang, Sun-Joo; Kim, Kyunghun; Dan-Chin-Yu, Alexey V.; Shishkov, Milen; Bouma, Brett E; Oh, Wang-Yuhl

    2013-01-01

    Intravascular optical frequency-domain imaging (OFDI), a second-generation optical coherence tomography (OCT) technology, enables imaging of the three-dimensional (3D) microstructure of the vessel wall following a short and nonocclusive clear liquid flush. Although 3D vascular visualization provides a greater appreciation of the vessel wall and intraluminal structures, a longitudinal imaging pitch that is several times bigger than the optical imaging resolution of the system has limited true ...

  17. MRI evaluation and follow-up of bone necrosis after meningococcal infection and disseminated intravascular coagulation

    Energy Technology Data Exchange (ETDEWEB)

    Damry, N. (Dept. of Radiology, Hopital Universitaire des Enfants Reine Fabiola, Brussels (Belgium)); Schurmans, T. (Dept. of Peadiatrics, Hopital Universitaire des Enfants Reine Fabiola, Brussels (Belgium)); Perlmutter, N. (Dept. of Radiology, Hopital Universitaire des Enfants Reine Fabiola, Brussels (Belgium))

    1993-10-01

    Disseminated intravascular coagulation (DIC) is a serious complication of meningococcal septicaemia. It often results in infarction of various tissues namely the skin, adrenal glands, kidneys, brain and, much less commonly, bones. We describe a patient who presented bone lesions after meningococcal septicaemia. In addition to plain radiography and scintigraphy the lesions were evaluated with MRI and have proved to be extensive and still progressive, approxximately 18 months after the onset of the disease. (orig.)

  18. Oxaliplatin induced disseminated intravascular coagulation: A case report and review of literature

    Directory of Open Access Journals (Sweden)

    Shweta Kurian

    2012-01-01

    Full Text Available Oxaliplatin in combination with a fluoropyrimide is a treatment option for colorectal cancer patients in the adjuvant and metastatic settings. Very few hematological emergencies have been reported associated with Oxaliplatin. These include autoimmune hemolytic anemia, thrombocytopenia and pancytopenia. We present a case report of a patient who developed hematuria and disseminated intravascular coagulation while receiving the second cycle of FOLFOX and bevacizumab for metastatic colon cancer.

  19. Intravascular pulmonary metastases from sarcoma: appearance on computed tomography in 3 cases

    International Nuclear Information System (INIS)

    Various common malignant neoplasms (ie, liver, kidney, stomach and breast) have been reported to embolize to the pulmonary arterial system. This uncommon occurrence can also result from metastatic sarcoma. We report 3 cases- 2 chondrosarcomas and 1 osteosarcoma-associated with intravascular motastases to the pulmonary vasculature and discuss the clinical presentation and differentiating radiologic features on computed tomography (CT). Intravascular pulmonary tumour emboli may present with nonspecific respiratory symptoms or remain completely asymptomatic, and therefore, many patients are often misdiagnosed with thromboembolic disease or undiagnosed until autopsy. Chest CTs in all our patients demonstrated a striking pattern of multifocal tubular branching beaded opacities along the pulmonary vasculature in a multilobular distribution. Our observations and a review of the literature indicate that chest CT is the most useful diagnostic tool for detecting intravascular pulmonary tumour emboli. CT can distinguish this entity from mucous plugging by demonstrating the normal adjacent bronchus. The tubular nature of these metastases distinguishes them from the more common parenchymal metastases. (author)

  20. Evaluation of CT virtual intravascular endoscopy in fenestrated stent grafts: a preliminary study

    International Nuclear Information System (INIS)

    We aim in this study to investigate the potential value of CT virtual intravascular endoscopy in patients diagnosed with abdominal aortic aneurysms undergoing fenestrated stent grafts. Both pre-and post-fenestration (within 3 months of implantation) multislice CT data were collected in eight patients and used for generation of virtual endoscopy images in our preliminary study. Variable fenestrations were deployed in 25 aortic branches with scallop fenestration implanted in six aortic ostia, large fenestration in four aortic ostia and small fenestration in 15 renal ostia, respectively. Measurements of the aortic ostia diameters both pre- and post-fenestration were successfully performed with virtual intravascular endoscopy visualization, and endovascular stents as well as their relationship to the aortic ostia were clearly demonstrated. Our results showed that there was no significant change of diameter of the aortic ostia following fenestrated stem grafts. Endovascular stents were clearly visualized on virtual endoscopy images, and no apparent deformity or malrotation was observed in this small group. Our preliminary study provides new insights into anatomic configuration/dimension of aortic ostia and endovascular stents, and virtual intravascular endoscopy could be a valuable technique to follow-up patients treated with fenestrated stent grafts. (orig.)

  1. Estimating the actual dose delivered by intravascular coronary brachytherapy using geometrically correct 3D modeling

    Science.gov (United States)

    Wahle, Andreas; Lopez, John J.; Pennington, Edward C.; Meeks, Sanford L.; Braddy, Kathleen C.; Fox, James M.; Brennan, Theresa M. H.; Buatti, John M.; Rossen, James D.; Sonka, Milan

    2003-05-01

    Intravascular brachytherapy has shown to reduce re-occurrence of in-stent restenosis in coronary arteries. For beta radiation, application time is determined from source activity and the angiographically estimated vessel diameter. Conventionally used dosing models assume a straight vessel with the catheter centered and a constant-diameter circular cross section. Aim of this study was to compare the actual dose delivered during in-vivo intravascular brachytherapy with the target range determined from the patient's prescribed dose. Furthermore, differences in dose distribution between a simplified tubular model (STM) and a geometrically correct 3-D model (GCM) obtained from fusion between biplane angiography and intravascular ultrasound were quantified. The tissue enclosed by the segmented lumen/plaque and media/adventitia borders was simulated using a structured finite-element mesh. The beta-radiation sources were modeled as 3-D objects in their angiographically determined locations. The accumulated dose was estimated using a fixed distance function based on the patient-specific radiation parameters. For visualization, the data was converted to VRML with the accumulated doses represented by color encoding. The statistical comparison between STM and GCM models in 8 patients showed that the STM significantly underestimates the dose delivered and its variability. The analysis revealed substantial deviations from the target dose range in curved vessels.

  2. Primary Intravascular large B-cell lymphoma of lung: a report of one case and review

    Directory of Open Access Journals (Sweden)

    Yu Hui

    2012-06-01

    Full Text Available Abstract Objective To investigate the clinicopathological features of primary intravascular large B-cell lymphoma of lung. Methods A case of primary pulmonary intravascular large B-cell lymphoma was analysed in histopathology and immunophenotype. Results The patient is a 42-year-old female who had cough for one year. Computed tomography showed ground-glass opacities and small nodules in bilateral lung fields. Histopathology demonstrated accumulation of similar sized neoplastic cells within alveolar capillaries, widening the alveolar septae. The alveolar structure sustained in part of districtions. Immunohistologically, the tumor cells were positive for CD20 and negative for CD3,CK, which were similar to the diffuse large B-cell lymphoma. Conclusions Intravascular large B-cell lymphoma is an uncommon type of non-Hodgkin’s lymphoma. Primary pulmonary presentation is even more rare. The diagnosis is based on the histopathology and immunohistochemistry. Virtual slides The virtual slide(s for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2076991810705433.

  3. Avaliação morfológica e imuno-histoquímica de linfomas gástricos primários Morphologic and immunohistochemical evaluation of primary gastric lymphomas

    OpenAIRE

    Jorge Alberto Thomé; Agnes Cristina Fett-Conte; José Antonio Cordeiro

    2005-01-01

    INTRODUÇÃO: Os linfomas gástricos primários representam cerca de 50% dos linfomas não-Hodgkin extranodais e de 2% a 8% das neoplasias malignas do estômago. A maioria é formada pela proliferação de linfócitos B, que ocorre a partir do tecido linfóide associado à mucosa. Esse tecido, inexistente no estômago em condições normais, surge como conseqüência de gastrite crônica, na maioria das vezes associada à bactéria Helicobacter pylori. A inflamação crônica provocada pela infecção bacteriana pare...

  4. Processos linfoproliferativos da pele: parte 2 - linfomas cutâneos de células T e de células NK Processos linfoproliferativos da pele: part 2 - cutaneous T-cell and NK-cell lymphomas

    OpenAIRE

    José Antonio Sanches Jr.; Claudia Zavaloni M. de Moricz; Cyro Festa Neto

    2006-01-01

    Os linfomas cutâneos de células T/NK constituem um grupo de doenças linfoproliferativas extranodais atualmente classificadas e subdivididas de acordo com o comportamento clínico segundo consenso da Organização Mundial de Saúde e da Organização Européia para Pesquisa e Tratamento do Câncer. Os linfomas cutâneos de células T/NK de comportamento clínico indolente compreendem a micose fungóide clássica, a micose fungóide foliculotrópica, a reticulose pagetóide, a cútis laxa granulomatosa, o linfo...

  5. Linfoma MALT de parótida, presentación de un caso clínico y revisión del tema Parotid MALT lymphoma, presentation of a clinical case and review of subject

    Directory of Open Access Journals (Sweden)

    Francisca Fernández A

    2012-04-01

    Full Text Available Los linfomas de las glándulas salivales son una entidad poco frecuente, estimándose una incidencia del 5%. La localización más habitual es la glándula parótida, seguida de la submaxilary la sublingual. La mayoría de los linfomas parotídeos son linfomas no Hodgkin (LNH y se consideran derivados del tejido linfoide asociado a mucosas (MALT. Infrecuentemente se han reportado estos casos y suelen ser subdiagnosticados por su presentación relativamente benigna, comportándose de forma localizada, de lento crecimiento, con varios años de evolución. Presentamos un caso clínico de linfoma tipo MALT de parótida de acuerdo a las características clínicas, histológicas e inmunohistoquímicas de este tumor. Además una revisión de la literatura de este caso.Lymphomas of the salivary glands are a rare entity, with an estimated incidence of 5%. The most frequent location is parotid gland, followed by the submandibular and sublingual. The majority of parotid lymphomas are non-Hodgkin's lymphoma NHL and are considered derived from mucosa-associated lymphoid tissue (MALT. Infrequently these cases have been reported and are often underdiagnosed for their presentation is relatively benign, localized behaving, slow growing, with several years of evolution. We report a case of parotid MALT lymphoma according to the clinical, histological and immunohistochemical characteristics of this tumor. In addition, a literature review of this case.

  6. Linfoma de células fusiformes: relato anatomopatológico de um caso com apresentação pulmonar Spindle cell lymphoma: a case with pulmonary presentation

    Directory of Open Access Journals (Sweden)

    Túlio Geraldo de Souza e Souza

    2006-02-01

    Full Text Available São raros os linfomas que se apresentam com padrão histológico de células fusiformes. Relatamos um caso de tumor pulmonar isolado em homem de 74 anos, diagnosticado em biópsia de agulha como neoplasia maligna de células fusiformes. Na ocasião, o estudo imuno-histoquímico favoreceu pseudotumor inflamatório. Sete meses após, o paciente foi laparotomizado devido a tumor perfurado intestinal. Os estudos anatomopatológico e imuno-histoquímico estabeleceram o diagnóstico de linfoma B difuso de grandes células. A revisão do tumor pulmonar revelou positividade franca para CD45 e CD20, confirmando o diagnóstico de Linfoma B de células fusiformes. Esta publicação visa a alertar para essa incomum apresentação dos linfomas, que necessita ser considerada, no diagnóstico diferencial de neoplasias de células fusiformes.This paper reports a rare malignant lymphoma with histological spindle-cell pattern. Seventy four year-old man presented with lung tumor. A diagnostic of spindle-cell malignant neoplasia was made and immunohistochemical studies were suggestive of inflammatory pseudotumor. Three months later, the patient returned to our service with acute abdomen. The surgery showed small Intestinal perforation associated with tumor. Microscopic examination and immunohistochemical studies revealed Diffuse B-large cell lymphoma. After the diagnostic of the intestinal tumor, the lung tumor was reviewed, showing positivity for CD45 and CD20 antibodies. This result supports the diagnostic of Spindle B-cell lymphoma, in the lung tumor. The aim of this report is to alert pathologists about this rare spindle cell pattern presentation of lymphomas, that must be differentiated from true sarcomas and others spindle-cell neoplasias.

  7. Linfoma não-Hodgkin bilateral do seio cavernoso como manifestação inicial da síndrome de imunodeficiência adquirida: relato de caso

    Directory of Open Access Journals (Sweden)

    Alan Kardec Barreira Junior

    2011-04-01

    Full Text Available Relato de caso com acometimento bilateral do seio cavernoso causado por linfoma não-Hodgkin em um paciente com síndrome da imunodeficiência adquirida. Paciente de 51 anos infectado pelo vírus da imunodeficiência adquirida há dois anos, sem terapia antirretroviral, apresentou-se com acometimento dos V e VI nervos cranianos bilateralmente. Exame de tomografia computadorizada de órbitas mostrou-se dentro da normalidade. Como a hipótese diagnóstica principal era afecção do ápice orbitário ou do seio cavernoso, foi realizado exame de imagem por ressonância magnética que evidenciou lesão compatível com linfoma acometendo os seios cavernosos. Apesar da raridade dos linfomas primários do sistema nervoso central, essa condição deve ser considerada entre os diagnósticos diferenciais nos pacientes imunodeprimidos que apresentem oftalmoplegia e sinais radiológicos sugestivos de lesão infiltrativa do seio cavernoso.

  8. Estabilidade lipídica de filés de carpa húngara congelados tratados com extratos de Lippia Alba

    OpenAIRE

    Ana Paula de Lima Veeck; Bruna Klein; Amanda Roggia Ruviaro; Andréia Quatrin; Lauren Fresinghelli Ferreira; Ana Paula Daniel; Jaqueline Piccolo; Maurício Schneider Oliveira; Carlos Augusto Mallmann; Berta Maria Heinzmann; Tatiana Emanuelli

    2015-01-01

    O objetivo do presente estudo foi avaliar o efeito da aspersão de extratos de Lippia alba na estabilidade lipídica de filés de carpa húngara armazenados a -18±2°C. Filés não tratados (controle sem aspersão) ou aspergidos (1mL 10g-1 de filé) com água destilada (controle água destilada) ou com extratos de L. alba (0,10g mL-1) hidrometanólico ou aquoso foram analisados durante o armazenamento nos dias zero, 90 e 180. Independente do tempo de congelamento, o extrato hidrometanólico reduziu os val...

  9. Modificaciones del timo de becerros tratados con clenbuterol para el consumo humano

    OpenAIRE

    Villar Pastor, Carlos Manuel

    2005-01-01

    Se estudian los efectos sobre el timo del P..2-agonistaclenbuterol utilizado ilegalmente como sustancia finalizadora en el engorde del ganado;considerando tanto su administración en solitario como asociado a la dexametasona. Para ello se utilizaron 18 terneros machos, Charolais x Retinto, de 12-14 meses de edad, que se asignan aleatoriamente en tres grupos experimentales: Grupo tratado con Clenbuterol (A, n=6); Grupo con clenbuterol más dexametasona (B, n=6); Grupo Control (n=6). Los efectos ...

  10. LAS INSTITUCIONES DE LOS TRATADOS ESTABLECIDAS EN LA CONSTITUCIÓN MEXICANA

    OpenAIRE

    Olguín-Torres, Antonio

    2015-01-01

    Derivado de la reforma constitucional de junio del 2011 y el resurgimiento de la importancia de los tratados en el sistema jurídico mexicano, se analizan los artículos 76 fracción I y 89 fracción X de la Constitución Política de los Estados Unidos Mexicanos en lo relacionado con las figuras del derecho internacional ampliamente desarrolladas en la doctrina como: terminación, denuncia, suspensión, modificación, enmienda, declaración interpretativa y reservas, con la finalidad de precisar tanto...

  11. Neoliberalismo y tratado de libre comercio: ¿hacia ciclos de guerra civil?

    OpenAIRE

    Saxe-Fernández, John

    2011-01-01

    El tratado de libre comercio TLC, es la formalización de una relación subordinada de México con Estados Unidos. El aperturismo mexicano ha sido marcado con mayor énfasis por los gobiernos de Porfirio Díaz y de Carlos Salinas de Gortari. El modelo económico derivado ha provocado la desviación de inversión pública al gasto no productivo, como el pago del servicio de la deuda, la liberación de precios junto al control salarial para reducir la inflación, con el propósito de "aumentar competitivid...

  12. Estudo do raspado de conjuntiva de pacientes tratados de retinoblastoma: Etapa II ¾ citologia

    OpenAIRE

    Santos Maria Carmen Menezes; Santos Gilda da Cunha; Vozza João Antônio; Medeiros Nivaldo; Erwenne Clélia Maria

    2002-01-01

    Objetivo: A citologia da conjuntiva humana tem sido amplamente estu-dada. A falta de dados sobre as características do raspado ocular em pacientes tratados de retinoblastoma submetidos à enucleação e radioterapia foi o que motivou este estudo. Métodos: Foram examinadas 114 órbitas de 58 pacientes. Este trabalho apresenta os resultados da citologia conjuntival, em 4 condições, com e sem enucleação, com e sem radioterapia. Resultados: No infiltrado leucocitário das órbitas com bulbo ocular pred...

  13. Do conceito de propriedade no Segundo tratado sobre o governo de John Locke

    Directory of Open Access Journals (Sweden)

    Amaro de Oliveira Fleck

    2012-12-01

    Full Text Available Embora o Segundo tratado sobre o governo não tenha por intuito fundamentar o conceito de propriedade, mas sim o de mostrar o que torna um governo legítimo e em que circunstâncias o recurso à resistência não pode ser considerado ilegal, a teoria da propriedade como algo que se adquire mediante o trabalho, contida nesta obra, foi a concepção predominante acerca da propriedade ao longo da época moderna. O presente artigo busca expor os argumentos contidos nesta teoria, tanto contextualizando-os dentro da argumentação geral da obra quanto mostrando no que diferem das fundamentações da propriedade precedentes

  14. Histopatologia das lâminas do casco de equinos com laminite aguda induzida e tratados com ketoprofeno, fenilbutazona e flunixin meglumine Histopathology of the digital laminae from horses with acute induced laminitis treated with ketoprophen, phenylbutazone, and flunixin meglumin

    Directory of Open Access Journals (Sweden)

    F.O. Paes Leme

    2010-04-01

    Full Text Available Avaliaram-se as alterações histológicas do tecido laminar, obtido por biopsia, em 20 equinos portadores de laminite induzida por sobrecarga de carboidratos e tratados com ketoprofeno, fenilbutazona ou flunixin meglumine. A biopsia foi colhida dos dígitos torácicos 72 horas após a indução. Os achados histológicos foram comparados com os achados de amostras de equinos isentos de laminite. Infiltrado inflamatório neutrofílico foi observado em 80%, congestão em 50%, hemorragia em 35% e hiperplasia na túnica íntima das arteríolas das lâminas dérmicas primárias em 15% das amostras. As taxas de microtrombos e coágulos foram 15% e 20%, respectivamente. Estes achados parecem decorrer dos distúrbios circulatórios que ocasionaram edema, congestão e hiperemia, seguidos de degeneração. Em 70% das análises realizadas nos animais tratados, as lesões histológicas foram inferiores aos graus de claudicação observados. Conclui-se que a biopsia de tecido laminar digital de equinos é viável, os artefatos decorrentes da técnica de biopsia não prejudicam a análise histológica das amostras e os anti-inflamatórios não esteroidais não são capazes de evitar as lesões laminares quando administrados após o início da sintomatologia clínica de laminite.Experimental laminitis caused by carbohydrate overload was induced in 20 healthy horses. Seventy two hours after induction, samples of the laminar tissue were obtained by biopsy from the thoracic limbs digits for histopathology. The histological findings were compared to samples from horses without laminitis. Neutrophilic infiltrate was observed in 80% of the samples, congestion in 50%, hemorrhage in 35%, and hyperplasia of the arteriolar intima layer of the primary dermal lamina in 15%. Thrombi and intravascular blood clots were observed in 15% and 20% of the samples, respectively. Apparently, these findings were due to circulatory changes that resulted in edema, congestion, and hyperemia, followed by degeneration. In 70% of analyses performed on treated horses, the histological lesions were less severe than the clinical signs of lameness. It is concluded that: (i the biopsy technique of laminar digital tissue from horses is viable; (ii the artifacts generated by the biopsy technique do not compromise the histological analyses; and (iii non-steroidal anti-inflammatory drugs do not avoid laminar lesions when administered after the beginning of clinical signs of laminitis.

  15. Linfoma de Hodgkin na infância e adolescência: 15 anos de experiência com o protocolo DH-II-90 Hodgkin's lymphoma in children and adolescents: 15 years of experience with the DH-II-90 protocol

    Directory of Open Access Journals (Sweden)

    Luciana N. S. Souza

    2010-01-01

    Full Text Available O desafio do tratamento do linfoma de Hodgkin na infância reside na redução da toxicidade aguda e tardia sem afetar os bons resultados terapêuticos. Crianças e adolescentes portadores de linfoma de Hodgkin recém-diagnosticado foram tratados com o protocolo institucional DH-II-90. Os objetivo deste trabalho foram: 1avaliar as taxas de sobrevida global (SG e livre de eventos (SLE do protocolo DH-II-90 aplicado a portadores de LH; 2avaliar as taxas de SG e SLE conforme estádio, idade, tumor "bulky", massa mediastinal, sintomas B, dose de radioterapia e 3descrever os efeitos tardios. Sessenta e oito pacientes portadores de LH recém-diagnosticado, com idade entre 0 e 21 anos (idade mediana 9 anos, 20F:48M, foram tratados com quimioterapia (baixo risco:ABVD; alto risco:ABVD+MOP/COP e radioterapia. O estadiamento foi distribuído desta forma: nove (13,2% estádio I A; 29 (42,6% II A; cinco (7,4% II B; nove (13,2% III A; dez (14,7% III B; dois (2,9% IV A e quatro (5,9% IV B. A SG em dez anos foi de 96,1% ± 3,8 para o grupo de baixo risco e 93,3% ± 4,5 para o de alto risco (p:0,402. A SLE foi de 88,9% ± 5,2 em dez anos para o de alto risco e 86,5% ± 6,3 para o de baixo risco (p: 0,969. A presença de massa mediastinal e doses de radioterapia maiores que 2100 cGy (p= 0,020 e p= 0,014, respectivamente apresentam impacto negativo na SLE e a doença estádio I tem impacto positivo na SLE. Disfunção e carcinoma de tireoide são os efeitos tardios mais frequentes neste grupo de doentes. O protocolo DH-II-90 obteve resultados terapêuticos favoráveis, porém as taxas de complicações tardias, embora aceitáveis, demandam revisão do programa terapêutico.The challenge of new protocols for Hodgkin's lymphoma (HL treatment is to decrease the toxicity without impairing the results. The DH-II-90 protocol was designed to treat children and adolescents with HL. The objectives of this work were: 1 to assess the overall and event free survival of patients with newly diagnosed HL treated with the DH-II-90 protocol, 2 to assess the overall and event free survival by stage, age, presence of bulky disease, mediastinal mass, B symptoms, dose and type of radiotherapy, and 3 to describe late effects, data collected from the patients' charts. Sixty-eight patients with HL, from 0 to 21 years of age (median age 9 yr, 20F:48M were treated with ABVD and involved-field radiotherapy for low-risk patients, and ABVD plus MOP or COP and extended field radiotherapy for high-risk patients. Stage distribution was: nine (13.2% stage I A; 29 (42.6% II A; five (7.4% II B; nine (13.2% III A; ten (14.7% III B; two (2.9% IV A and four (5.9% IV B. The 10-year overall survival was 96.1% ± 3.8% for the low-risk group and 93.3% ± 4.5% for the high-risk group (p= 0.402. The 10-year event free survival was 88.9% ± 5.2% for high-risk and 86.5% ± 6.3% for low-risk patients (p= 0.969. The presence of mediastinal mass and more than 2100 cGy radiation doses had negative impact on event free survival (p= 0.020 and p= 0.014, respectively.Thyroid gland dysfunction was frequently observed and there were two cases of thyroid carcinoma. The DH-II-90 protocol is effective, but, due to the late effects presented by this group of patients, further modifications of the therapy schedule are required.

  16. Estabilidade lipídica de filés de carpa húngara congelados tratados com extratos de Lippia Alba

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    Ana Paula de Lima Veeck

    2015-06-01

    Full Text Available O objetivo do presente estudo foi avaliar o efeito da aspersão de extratos de Lippia alba na estabilidade lipídica de filés de carpa húngara armazenados a -18±2°C. Filés não tratados (controle sem aspersão ou aspergidos (1mL 10g-1 de filé com água destilada (controle água destilada ou com extratos de L. alba (0,10g mL-1 hidrometanólico ou aquoso foram analisados durante o armazenamento nos dias zero, 90 e 180. Independente do tempo de congelamento, o extrato hidrometanólico reduziu os valores de dienos conjugados (DC dos filés em relação aos demais tratamentos, além de reduzir os valores de ácidos graxos livres aos 90 dias (P<0,05. O extrato aquoso resultou em maior teor de peróxidos após 180 dias de congelamento comparado aos demais tratamentos (P<0,05. Os extratos hidrometanólico e aquoso reduziram os valores de substâncias reativas ao ácido tiobarbitúrico (TBARS após 180 dias, comparados aos filés tratados com água destilada e sem aspersão (P<0,05. Ambos os extratos de L. alba retardaram a oxidação lipídica, sendo que o extrato aquoso retardou a degradação de produtos primários da oxidação lipídica (peróxidos em produtos secundários (TBARS, enquanto o extrato hidrometanólico parece ser mais eficiente, pois inibiu de forma similar tanto a formação de DC e peróxidos, quanto a sua degradação em produtos secundários (TBARS

  17. Considerações sobre a prevalência dos tratados internacionais sobre a legislação tributária brasileira: o caso do MERCOSUL

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    Maria de Fátima Ribeiro

    1997-12-01

    Full Text Available This is a study on the main aspects discussed in the Brazilian doctrine and the jurisprudence concerning the prevalence of international treaties and conventions for internal tax legislation. Considerations are made on the Brazilian federate and sovereignty principles and on the competence constitutionally established for all the political entities of the Brazilian State. Article 151, section III of the Federal Constitution must be pointed out for its purpose on stating that the Union shall not exempt the States, the Federal District and the Municipalities from respective taxes. Article 98 of the National Tax Code is also considered for its disposition concerning legislation from international treaties and agreements on tax norms of the positive system currently in force.Trata-se de estudo sobre os principais aspectos discutidos na doutrina e na jurisprudência brasileira sobre a prevalência dos tratados e convenções internacionais sobre a legislação tributária interna. Necessário se faz apresentar considerações sobre o princípio federativo brasileiro, o princípio da soberania e o da competência constitucionalmente estabelecida para todos os entes políticos do Estado brasileiro. Merece maior destaque o art. 151, inciso III da Constituição Federal ao enaltecer que a União não poderá conceder isenções de tributos de competência dos Estados, Distrito Federal e Municípios, bem como a análise do art. 98 do Código Tributário Nacional dispondo sobre as introduções legislativas provenientes de tratados e acordos internacionais sobre as normas tributárias do sistema positivo vigente.

  18. Un tratado sobre la extranjería de lo propio (El uruguayo de Copi

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    María Negroni

    2006-11-01

    Full Text Available El uruguayo de Copi es un tratado sobre la lengua, una descripción desopilante de un país, un ácido comentario político, una burla impiadosa de los valores culturales, una pesadilla personal, un golpe de teatro donde cualquier versión de la realidad se vuelve precaria y se trastoca al compás de una imaginación afiebrada que no hace más que dar rienda suelta a los materiales del inconsciente. Pero sobre todo, es la visión desnuda de la relación imposible de un escritor con el país que ha dejado atrás. Un tratado sobre el horror de confrontarse con la realidad carcelaria del pasado. Un intento de "calmar" los fantasmas, es decir, de hacerlos hablar y moverse y morir y resucitar en una trama que transita en medio de cadáveres y mares desaparecidos y un territorio que se achica constantemente. Un texto fundamental para indagar cuestiones relacionadas con la "identidad" nacional y con las maneras en que los desplazamientos culturales (con su concomitante tránsito entre lenguas y visiones del mundo, tan comunes en el mundo actual, afectan la escritura.

  19. EL SISTEMA EUROPEO DE DERECHOS FUNDAMENTALES TRAS LA ENTRADA EN VIGOR DEL TRATADO DE LISBOA

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    Lorenzo Martín-Retortillo Baquer

    2011-07-01

    Full Text Available Resumen: En 1947 se pusieron las bases de lo que llegaría a ser la Unión Europea, a modo de organización comercial para sectores concretos, complejo que iría creciendo, ampliándose los fines y la organización, a la par que se fraguaba un complejo ordenamiento jurídico. Se hizo necesario alcanzar una declaración de derechos que incluyera los modernos derechos sociales. En el trabajo se estudia la compleja historia de la obtención de la declaración, la “Carta de Derechos Fundamentales de la Unión Europea”, que, al fin, entraría en vigor el 1.XII.2009, a la par que el último de los Tratados de la Unión, el Tratado de Lisboa.Abstract: The European Union was founded in 1947 as a concrete trade organization but it started to grown. The aims and the organization had increased and in the meantime a complex law system was set up. It was convenient to get a solid bill of rights including the modern social rights. The paper studies the complicate story of how to obtain the bill of rights –the “Carta of Fundamentals Rights of the European Union”- which formally came into effect the 1.XII.2099 at the same time that the last Treaty of the Union, the Treaty of Lison.

  20. Osteogénesis por distracción en defectos mandibulares y su estabilidad esquelética a los 2 años de tratados

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    Dadonim Vila Morales

    2011-03-01

    Full Text Available El presente estudio tiene como objetivo mostrar los resultados de la estabilidad esquelética a los 2 años de operados, de los primeros pacientes con hipoplasias mandibulares tratados con distracción osteogénica en nuestro país. Se trataron 11 hemimandíbulas en 7 pacientes con distracción osteogénica mandibular, con distractores marca Leibinger. El periodo de latencia fue de 72 horas, la distracción mandibular se aplicó a razón de 1,0 mm cada 12 horas y la contención fue de 8 semanas. Luego se inició el tratamiento ortodóncico posquirúrgico. Se evaluaron los resultados a través de estudios cefalométricos antes de la intervención, luego y a los 2 años del tratamiento hubo cambios esqueléticos posoperatorios significativos en las mediciones angulares cefalométricas SNB y ANB, con p< 0,05. La media aritmética de la osteodistracción obtenida en rama, fue de 7,5 mm y en el cuerpo de 8,0 mm. A los 2 años existió una estabilidad ósea mandibular de 88,8 % evaluada de buena. Los cambios oclusales fueron favorables. No existieron complicaciones que afectaran la buena evolución de los pacientes tratados. Se demostró que la distracción ósea es un método eficaz para el tratamiento de defectos mandibulares.

  1. Un regimen sanitatis contra la peste: el tratado del licenciado Vázquez

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    de la Peña Barroso, Efrén

    2012-12-01

    Full Text Available The regimina pestis or plague treatises are the main literary genre where late medieval doctors reflected their medical concern about plague and pestilences. These medical texts, in which some practical recommendations were given to people to avoid and/or cure the effects of epidemic disease of high letality, were developed since the outbreak of the epidemic in 1348. The text now presented is a treatise on plague written by the «licenciado Vázquez», a converso from the archbishopric of Toledo who was tried by the Inquisition at the beginning of the 16th Century.Los regimientos o tratados contra la peste o pestilencia son expresión del modo en que los médicos universitarios bajomedievales hicieron frente a la enfermedad epidémica de alta letalidad. Estos textos médicos, que consistían en un repertorio más o menos amplio de recomendaciones prácticas para prevenir y/o tratar dicha enfermedad, experimentaron un notable desarrollo a partir de la peste negra de 1348. El texto que se ofrece a continuación es un tratado inédito contra la peste escrito por el licenciado Vázquez, un judeoconverso toledano que fue procesado por el Tribunal de la Inquisición a principios del siglo XVI.

  2. Alterações vasculares na coróide de ratos diabéticos tratados e não tratados Choroidal vessels alterations in treated and untreated diabetic rats

    OpenAIRE

    Antonio Carlos Lottelli Rodrigues; Silvana Artioli Schellini; César Tadeu Spadela; Elisa Aparecida Gregório; Carlos Roberto Padovani

    2007-01-01

    OBJETIVO: Conhecer os efeitos do diabetes e o impacto de seu tratamento medicamentoso em curto e longo prazo sobre os vasos da coróide e membrana de Bruch. MÉTODOS: Foram estudados 30 ratos Wistar, divididos em 3 grupos experimentais: grupo controle (GC), grupo diabético (GD) e grupo diabético tratado (GT), estudados 1 mês (momento M1) e 12 meses (momento M2) após o início do experimento. O diabetes foi induzido por aloxana endovenosa, na dose de 42 mg/kg. O GT foi tratado com hipoglicemiante...

  3. El Tratado de no Proliferación Nuclear: la vigencia de la norma en América Latina

    OpenAIRE

    Adela Cubillos Meza

    2005-01-01

    RESUMEN En este artículo se analiza la posición de los países de América Latina frente al Tratado de No Proliferación Nuclear TNP. Este Tratado entró en vigencia el año 1968 al que se adhirió una gran cantidad de países. Los artífices del TNP fueron las potencias nucleares, Estados Unidos y la ex Unión Soviética, para controlar la proliferación nuclear. Este Tratado ha sido objeto de grandes críticas porque discrimina entre Estados Poseedores de Armas Nucleares y Estados No Poseedores de Arma...

  4. Legitimidad y finalidad de los capítulos de propiedad intelectual en los tratados de libre comercio (TLC)

    OpenAIRE

    Susy Frankel

    2011-01-01

    Una visión analítica de la realidad actual permite apreciar un auge de los Tratados de Libre Comercio, mientras se presenta un estancamiento en las negociaciones multilaterales de comercio. Si bien la negociación de los TLC no se limita a los países desarrollados, los negociados por los países en desarrollo no tienden a contemplar mejoras en los estándares de propiedad intelectual. Algunos de los capítulos relativos a la propiedad intelectual incluidos en los Tratados de Libre Comercio simple...

  5. Management of subarachnoid hemorrhage classified grade V. Possibility of intravascular treatment

    International Nuclear Information System (INIS)

    Management outcomes in poor-grade patients (World Federation of Neurological Surgeons Committee on a Universal Subarachnoid Hemorrhage Grading Scale Grade V) with ruptured cerebral aneurysms have historically been unsatisfactory. In the present study, we examined the possibility of intravascular treatment for ruptured aneurysm detected by 3-Dimensional CT angiography (3D-CTA) in poor-grade SAH patients. From April 1997 to July 2000, 3D-CTA was performed on 54 of 73 patients admitted with Grade V subarachnoid hemorrhage (SAH). Excluding 3 patients who underwent emergency surgery for ruptured aneurysms and intracerebral hematomas, CT findings from the remaining 51 patients were analyzed. The study included 23 men and 28 women, ranging in age from 28 to 91 with an average age of 63.6. The patients' initial scores on the Glasgow Coma Scale upon admission were 3 in 36 patients (including 19 patients who had undergone cardio-pulmonary arrest), 4 in 11 patients, 5 in 2 patients, and 6 in 2 patients. Ruptured aneurysms responsible for SAH were clearly delineated in 41 aneurysms from 39 patients, with 32 aneurysms in the anterior circulation and 9 in the posterior circulation. Patients with Glasgow Coma Scale of 4 or higher whose score did not progressively decrease for 12 hours after symptom onset were considered for intravascular treatment. In our study, 4 of 39 patients (10.3%) met these criteria. Glasgow Outcome Scale results were good recovery in 1 case, moderate disability in 1 case, severe disability in 1 case, and death in the remaining 48 cases. These results suggest that the management course for poor-grade (WFNS Grade V) SAH patients who retain brain stem reflexes contain the following: identification of aneurysms by 3D-CTA, maintenance of adequate sedation and external drainage to treat acute hydrocephalus, continued minimum 12-hour observation, monitoring levels of consciousness where possible, and consideration of aggressive therapy including intravascular treatment. (author)

  6. Management of subarachnoid hemorrhage classified grade V. Possibility of intravascular treatment

    Energy Technology Data Exchange (ETDEWEB)

    Uzura, Masahiko; Oshima, Kousuke; Morishima, Hiroyuki; Uchida, Kazuyoshi; Watanabe, Hiroyuki; Nakamura, Homare; Tanaka, Katsuyuki; Sekino, Hiroaki; Akashi, Katsuya [St. Marianna Univ., Kawasaki, Kanagawa (Japan). School of Medicine

    2001-10-01

    Management outcomes in poor-grade patients (World Federation of Neurological Surgeons Committee on a Universal Subarachnoid Hemorrhage Grading Scale Grade V) with ruptured cerebral aneurysms have historically been unsatisfactory. In the present study, we examined the possibility of intravascular treatment for ruptured aneurysm detected by 3-Dimensional CT angiography (3D-CTA) in poor-grade SAH patients. From April 1997 to July 2000, 3D-CTA was performed on 54 of 73 patients admitted with Grade V subarachnoid hemorrhage (SAH). Excluding 3 patients who underwent emergency surgery for ruptured aneurysms and intracerebral hematomas, CT findings from the remaining 51 patients were analyzed. The study included 23 men and 28 women, ranging in age from 28 to 91 with an average age of 63.6. The patients' initial scores on the Glasgow Coma Scale upon admission were 3 in 36 patients (including 19 patients who had undergone cardio-pulmonary arrest), 4 in 11 patients, 5 in 2 patients, and 6 in 2 patients. Ruptured aneurysms responsible for SAH were clearly delineated in 41 aneurysms from 39 patients, with 32 aneurysms in the anterior circulation and 9 in the posterior circulation. Patients with Glasgow Coma Scale of 4 or higher whose score did not progressively decrease for 12 hours after symptom onset were considered for intravascular treatment. In our study, 4 of 39 patients (10.3%) met these criteria. Glasgow Outcome Scale results were good recovery in 1 case, moderate disability in 1 case, severe disability in 1 case, and death in the remaining 48 cases. These results suggest that the management course for poor-grade (WFNS Grade V) SAH patients who retain brain stem reflexes contain the following: identification of aneurysms by 3D-CTA, maintenance of adequate sedation and external drainage to treat acute hydrocephalus, continued minimum 12-hour observation, monitoring levels of consciousness where possible, and consideration of aggressive therapy including intravascular treatment. (author)

  7. Ischemia monitoring in off-pump coronary artery bypass surgery using intravascular near-infrared spectroscopy

    Directory of Open Access Journals (Sweden)

    Zerkowski Hans-Reinhard

    2006-05-01

    Full Text Available Abstract Background In off-pump coronary artery bypass surgery, manipulations on the beating heart can lead to transient interruptions of myocardial oxygen supply, which can generate an accumulation of oxygen-dependent metabolites in coronary venous blood. The objective of this study was to evaluate the reliability of intravascular near-infrared spectroscopy as a monitoring method to detect possible ischemic events in off-pump coronary artery bypass procedures. Methods In 15 elective patients undergoing off-pump myocardial revascularization, intravascular near-infrared spectroscopic analysis of coronary venous blood was performed. NIR signals were transferred through a fiberoptic catheter for signal emission and collection. For data analysis and processing, a miniature spectrophotometer with multivariate statistical package was used. Signal acquisition and analysis were performed before and after revascularization. Spectroscopic data were compared with hemodynamic parameters, electrocardiogram, transesophageal echocardiography and laboratory findings. Results A conversion to extracorporeal circulation was not necessary. The mean number of grafts per patient was 3.1 ± 0.6. An intraoperative myocardial ischemia was not evident, as indicated by electrocardiogram and transesophageal echocardiography. Continuous spectroscopic analysis showed reproducible absorption spectra of coronary sinus blood. Due to uneventful intraoperative courses, clear ischemia-related changes could be detected in none of the patients. Conclusion Our initial results show that intravascular near-infrared spectroscopy can reliably be used for an online intraoperative ischemia monitoring in off-pump coronary artery bypass surgery. However, the method has to be further evaluated and standardized to determine the role of spectroscopy in off-pump coronary artery bypass surgery.

  8. Effect of intravascular irradiation of He-Ne laser on cerebral infarction: Hemorrheology and apoptosis

    Science.gov (United States)

    Zhu, Jian; Liang, Min-yi; Cao, Hao-cai; Li, Xiao-Yuan; Li, Shao-ming; Li, Shun-hao; Li, Wen-qi; Zhang, Jin-hong; Liu, Lei; Lai, Jian-hong

    2005-07-01

    Objective: To explore the efficacy of He-Ne laser intravascular irradiation on infarction and hemorrheology. To observe the effects of intravascular low level He-Ne laser irradiation (ILLLI) of blood on cell proliferation, apoptosis and chromosome in lymphocyte from cerebral infarction Methods: Seventy cases with cerebral infarction were randomly divided into groups control group (35 cases) treated only with common drugs and therapeutic group (35 cases) treated besides common drugs also by He-Ne laser intravascular irradiation. Their hemorrheology index and treatment results were observed and compared. The blood lymphocytes of cerebral infarction were cultured before and after treatment. After that, the mitosis index (MI), cell kinetics index (CKI), sister-chromatid exchanges (SCE) frequencies and apoptosis were determined. Results The therapeutic group was better than the control one. The effective rate in the therapeutic group was 88.6%, in the control one was 65.7%. The viscosity and fibrinogen, etc were better than that in the control group with significant difference (P0.05) in cerebral infarction patients after treatment; The CKI of lymphocytes had no obvious difference among groups (P>0.05) SCE frequencies of lymphocytes had no statistic significance between control group and ILLLI on (P>0.05). It showed the apoptosis rate of lymphocytes in cerebral infarction patients after ILLLI treatment increased significantly compared with the control group, (Pcerebral infarction patients than the control (Pcerebral infarction, the low level He-Ne by ILLLI can increase the proliferation of lymphocytes, and can induce lymphocytes to apoptosis, but has no mutagenicity of cells.

  9. Frequency-Domain Intravascular Optical Coherence Tomography of the Femoropopliteal Artery

    International Nuclear Information System (INIS)

    Purpose: Optical coherence tomography (OCT) is a catheter-based imaging method that employs near-infrared light to produce high-resolution intravascular images. The authors report the safety and feasibility and illustrate common imaging findings of frequency-domain OCT (FD-OCT) imaging of the femoropopliteal artery in a series of 20 patients who underwent infrainguinal angioplasty. Methods: After crossing the lesion of interest, OCT was performed with a dextrose saline flush technique with simultaneous obstructive manual groin compression. An automatic pullback FD-OCT device was employed (each scan acquiring 54 mm of vessel lumen in 271 consecutive frames). OCT images were acquired before and after balloon dilatation and following provisional stenting if necessary and were evaluated for baseline characteristics of plaque or in-stent restenosis (ISR), vessel wall trauma after angioplasty, presence of thrombus, stent apposition, and tissue prolapse. Imaging follow-up was not included in this study’s protocol. Results: Twenty-seven obstructive lesions (18 cases of de novo atherosclerosis and 9 of ISR) of the femoropopliteal artery were imaged and 148 acquisitions were analyzed in total. High-resolution intravascular OCT imaging with effective blood clearance was achieved in 93.9%. Failure was mainly attributed to preocclusive proximal lesions and/or collateral flow. Mixed features of lipid pool areas, calcium deposits, necrotic core, and fibrosis were identified in all of the imaged atherosclerotic lesions, whereas ISR was purely fibrotic. After balloon angioplasty, OCT identified extensive intimal tears in all cases and one case of severe dissection that biplane subtraction angiography failed to identify. Conclusions: Infrainguinal frequency-domain optical coherence tomography is safe and feasible and may provide intravascular high-resolution imaging of the femoropopliteal artery during infrainguinal angioplasty procedures.

  10. Acute disseminated intravascular coagulation developed after dilation and curettage in an adenomyosis patient: a case report.

    Science.gov (United States)

    Zhang, Jing; Xiao, Xiong; Luo, Fangyuan; Shi, Gang; He, Yanmei; Yao, Yuan; Xu, Liangzhi

    2013-10-01

    We reported a rare case of acute disseminated intravascular coagulation (DIC) after dilation and curettage in an adenomyosis and missed abortion patient. The clinical performance improved after treatment with tranexamic acid, blood transfusions and subtotal hysterectomy. Hemorrhage, degeneration and necrosis were found in the myometrium. Pregnancy-related thrombotic tendency, accelerated uterus tissue injury after curettage, activation of coagulation system, microthrombosis formation, myometrium necrosis, exhaustion of coagulation factors and hyperfibrinolysis might play the crucial roles in the pathophysiology of acute DIC. Physicians should be alert that adenomyosis patients undergoing dilation and curettage may be in danger of DIC. PMID:23867345

  11. Lead-Free Intravascular Ultrasound Transducer Using BZT-50BCT Ceramics

    OpenAIRE

    Yan, Xingwei; Lam, Kwok Ho; Li, Xiang; Chen, Ruimin; REN, WEI; Ren, Xiaobing; Zhou, Qifa; Shung, K. Kirk

    2013-01-01

    This paper reports the fabrication and evaluation of a high-frequency ultrasonic transducer based on a new lead-free piezoelectric material for intravascular imaging application. Lead-free 0.5Ba(Zr0.2Ti0.8)O3?0.5(Ba0.7Ca0.3)TiO3 (BZT-50BCT) ceramic with a high dielectric constant (~2800) was employed to develop a high-frequency (~30 MHz) needle-type ultrasonic transducer. With superior piezoelectric performance (piezoelectric coefficient d33 ~ 600 pC/N), the lead-free transducer was found to ...

  12. Fixed Coronary Artery Stenosis in Tunneled Coronary Artery Identified by Intravascular Ultrasound: A Case Report

    Directory of Open Access Journals (Sweden)

    Yuxiang Dai

    2014-10-01

    Full Text Available Myocardial bridging is characterized as the compression of a segment of the coronary artery during systole. Significant atherosclerosis within the bridge is almost never seen at pathologic examination because of the absence of synthetic type smooth muscle cells in the intima of the tunneled artery. To date, there have been no reports of significant atherosclerosis at the site of myocardial bridging documented by angiography or intravenous ultrasound. We report a rare case of fixed coronary artery stenosis at the site of myocardial bridging identified by intravascular ultrasound.

  13. Disseminated intravascular coagulation or acute coagulopathy of trauma shock early after trauma? A prospective observational study

    DEFF Research Database (Denmark)

    Johansson, Per Ingemar; Sorensen, Anne Marie; Perner, Anders; Welling, Karen-Lise; Wanscher, Michael; Larsen, Claus F; Ostrowski, Sisse R

    2011-01-01

    ABSTRACT: INTRODUCTION: It is debated whether the early trauma induced coagulopathy (TIC) in severely injured patients reflects disseminated intravascular coagulation (DIC) with a fibrinolytic phenotype, acute coagulopathy of trauma shock (ACoTS) or yet other entities. This study investigated the...... prevalence of overt DIC and ACoTS in trauma patients and characterized these conditions based on their biomarker profiles. METHODS: Observational study at a single Level I Trauma Centre. Inclusion of 80 adult trauma patients ([greater than or equal to]18 years) who met criteria for full trauma team...

  14. Rash, disseminated intravascular coagulation and legionella: Episode 10 and a rewind into the past

    Directory of Open Access Journals (Sweden)

    Prashanth M. Thalanayar

    2015-01-01

    Full Text Available Legionella pneumophila is the most common cause of legionellosis and is one of the organisms causing atypical pneumonia. We report the presentation of disseminated intravascular coagulation (DIC and skin rash in a single case of severe Legionella pneumonia. The unique clinical presentation of a diffuse rash diagnosed as purpura fulminans and the unpredictable variations encountered during the diagnostic work-up of the case make this write-up crucial. This article synthesizes all reported cases of L. pneumonia associated with cutaneous manifestations as well as cases presenting with DIC. Furthermore, this manuscript illustrates the correlation between cutaneous and coagulopathic manifestations, and morbidity and mortality from L. pneumonia.

  15. Enterocolic Lymphocytic Phlebitis with Disseminated Intravascular Coagulation-Like Features - A Case Report

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    Tomohiro Kadota

    2012-05-01

    Full Text Available We report herein a case of colonic infarction caused by lymphocyticphlebitis. Due to its very rare occurrence, a correct diagnosis was notmade until a surgical specimen was obtained. Initially, the patient wastreated conservatively as severe colitis, but subsequent laboratorytest results suggested worsening of the general condition includingdisseminated intravascular coagulation (DIC, thus, colectomy wasperformed. After the operation, the patient’s condition improvedrapidly and completely. The excessive consumption of platelets andcoagulation factors, which promoted the DIC-like features, wasthought to have been restricted to the inflamed veins of the damagedcolon.

  16. Prostate Cancer-Associated Disseminated Intravascular Coagulation with Excessive Fibrinolysis Treated with Degarelix

    Science.gov (United States)

    Ong, Shawn Y.; Taverna, Josephine; Jokerst, Clint; Enzler, Thomas; Hammode, Emad; Rogowitz, Elisa; Green, Myke R.; Babiker, Hani M.

    2015-01-01

    Disseminated intravascular coagulation (DIC) with excessive fibrinolysis (XFL) is a rare and acute life-threatening variant of DIC in patients with prostate cancer. Patients present with coagulopathy, hypofibrinogenemia, and systemic bleeding. We describe a case of DIC XFL caused by prostate cancer (PC) successfully treated with a single injection of degarelix, a gonadotropin-releasing hormone (GnRH) receptor antagonist. This led to prompt control of the patient's coagulopathy within ten days of treatment. Our case highlights features of this rare and devastating hemorrhagic complication of PC along with a fast-acting and effective therapeutic drug option. PMID:26613055

  17. Disseminated intravascular coagulation in a patient with metastatic prostate cancer: Fatal outcome following strontium-89 therapy

    Energy Technology Data Exchange (ETDEWEB)

    Leong, C.; McKenzie, R.; Coupland, D.B. [Univ. of British Columbia, (Canada)] [and others

    1994-10-01

    A patient with metastatic prostate cancer was found to have low-grade disseminated intravascular coagulation (DIC). He had significant bone pain despite external-beam radiotherapy and was given {sup 89}Sr with subsequent thrombocytopenia and epistaxis. The patient died from generalized hemorrhage 36 days postinjection. Although it is not possible to establish a causal relationship between {sup 89}Sr and DIC, practitioners should be alert to complications associated with the primary disorder which might occur at a time to raise concern about the intervention. 8 refs., 1 tab.

  18. Diagnóstico de linfomas cutáneos mediante detección de clonalidad por PCR-heterodúplex Diagnosis of cutaneous lymphomas by clonicity detection through PCR-heteroduplex technique

    Directory of Open Access Journals (Sweden)

    Ana M. Amor Vigil

    2008-04-01

    Full Text Available La detección de clonalidad en los síndromes linfoproliferativos mediante el estudio del reordenamiento de los genes de las inmuglobulinas y del receptor de células T, es utilizada para esclarecer si una proliferación o infiltrado de linfocitos es maligno o no. Este tipo de estudio es de particular utilidad en presencia de lesiones cutáneas cuyo origen linfoide o dermatológico resulta difícil de definir. Mediante la técnica de PCR-heterodúplex se estudiaron los genes de la cadena pesada de las inmunoglobulinas y de la cadena gamma del receptor de las células T, en 10 pacientes que presentaban manifestaciones dermatológicas atribuibles a algún tipo de linfoma cutáneo. Se observó reordenamiento clonal en 7 pacientes, lo cual permitió confirmar el diagnóstico de micosis fungoide y otros tipos de linfomas cutáneos. En 3 pacientes que no mostraron reordenamiento clonal, no fue posible confirmar por esta técnica un proceso linfoide de carácter maligno. Se demostró la utilidad del estudio cuando en presencia de una afección en la piel, es difícil diferenciar un proceso dermatológico de un síndrome linfoproliferativo con manifestaciones en piel.The clonicity detection in the lymphoproliferative syndromes by studying the rearrangement of the immunoglobulin genes and of the T-receptor cells is used to make clear if a proliferation or infiltrate of lymphocytes is malignant or not. This type of study is particularly useful in the presence of cutaneous lesions whose lymphoid or dermatological origin is difficult to define. By the PCR-heteroduplex technique, the genes of the immunoglobulin heavy chain and of the T-cell receptor chain were studied in 10 patients that presented dermatological manifestations attributable to some kind of cutaneous lymphoma. Clonal rearrangement was observed in 7 patients, which allowed to confirm the diagnosis of mycosis fungoides and other types of cutaneous lymphomas. It was not possible to confirm a lymphoid process of malignant character by this technique in 3 patients who did not show clonal rearrangement. The usefulness of the study was proved when in the presence of a skin affection, it was difficult to differentiate a dermatological process from a proliferative syndrome with cutaneous manifestations.

  19. El Tratado de no Proliferación Nuclear: la vigencia de la norma en América Latina

    Directory of Open Access Journals (Sweden)

    Adela Cubillos Meza

    2005-01-01

    Full Text Available RESUMEN En este artículo se analiza la posición de los países de América Latina frente al Tratado de No Proliferación Nuclear TNP. Este Tratado entró en vigencia el año 1968 al que se adhirió una gran cantidad de países. Los artífices del TNP fueron las potencias nucleares, Estados Unidos y la ex Unión Soviética, para controlar la proliferación nuclear. Este Tratado ha sido objeto de grandes críticas porque discrimina entre Estados Poseedores de Armas Nucleares y Estados No Poseedores de Armas Nucleares, así los primeros pueden fabricar artefactos atómicos, pero a los segundos les está prohibido. Incluso potencias nucleares como Francia y China no se adhirieron de inmediato, por considerarlo altamente discriminatorio. También los Estados No Poseedores de Armas Nucleares, han sido grandes críticos del TNP y no se adhirieron de inmediato, entre ellos tres países Latinoamericanos, Argentina, Brasil y Chile. Los dos primeros sólo firmaron el TNP cuando lograron plena capacidad y autonomía en materia nuclear. La no adhesión inmediata de Chile estuvo condicionada por la decisión de Argentina y Brasil.ABSTRACT The position of Latin American countries within the framework of the Non Nuclear Proliferation Treaty NPT is analyzed in this article. This treaty which entered into force in 1968, has been ratified by a significant number of countries. The nuclear- weapon states, the United States and the former USSR gave origin to the NPT in order to control nuclear proliferation. This treaty has been subject to criticism since it discriminates between the countries which have nuclear weapons and the ones that do not. Thus, the former are allowed to manufacture atomic devices, but it has been forbidden for the latter. Even nuclear- weapon states such as France and China did not support the treaty immediately because they consider it as highly discriminatory. Countries that do not have nuclear weapons have criticized the NPT and did not joined immediately. Among these parties, we can mention three Latin American countries, Argentina, Brazil and Chile. The first two only signed the NPT when they were fully capable and autonomous in nuclear power. The Chilean position of not joining immediately depended upon the Argentinian and Brazilian decision.

  20. MORFOLOGIA DO TIMO DE COELHOS NOVA ZELÂNDIA BRANCO TRATADOS COM GENTAMICINA

    Directory of Open Access Journals (Sweden)

    Matheus Henrique Magalhães Silva

    2013-06-01

    Full Text Available Considering the thymus importance for the immune system and the immunodepressive potential of gentamicin, this study aimed to evaluate the effects of this aminoglycoside on the thymus histology of New Zealand White rabbits. For this, it were used 20 adult rabbits, 10 males and 10 females with a mean weight of 2.5 kg, healthy, of the New Zealand White breed, which were divided into two groups (control and treated, with five males and five females each. After seven days of daily treatment with 4.4 mg/kg of gentamicin by subcutaneous injection, on the eighth day the animals were sacrificed and their thymuses, after collected, were fixed in Bouin solution for 24 hours and processed routinely for embedded in paraffin. After the semi-serial microtome with thickness of 5 µm at intervals of 1000 µm, the histological sections were stained using Masson’s Trichrome techniques. It were analyzed, by light microscopy, the morphological characteristics of cortical and medullary of thymic individualized lobes of these sections. It was not observed histological differences between sexes or between control and treated groups. The results showed that this antibiotic, used in therapeutic dosage and by the recommended period, did not alter the morphology of the thymus of treated animals.Considerando-se a importância do timo para o sistema imunológico e o potencial imunodepressor da gentamicina, este estudo objetivou avaliar os efeitos deste aminoglicosídeo sobre a histologia do timo de coelhos da raça Nova Zelândia Branco. Para isto, utilizou-se 20 coelhos adultos, 10 machos e 10 fêmeas, com peso médio de 2,5 kg, hígidos, da raça Nova Zelândia Branco, os quais foram divididos em dois grupos (controle e tratado com cinco machos e cinco fêmeas cada. Após sete dias de tratamento diário com 4,4 mg/kg de gentamicina por via subcutânea, no oitavo dia, os animais foram sacrificados e seus timos, após coletados, foram fixados em solução de Bouin por 24 horas e processados, rotineiramente, para a inclusão em parafina. Após a microtomia semi-seriada, à espessura de 5 µm, com intervalos de 1000 µm, os cortes histológicos foram corados pelas técnicas do Tricrômico de Masson. Analisou-se, por meio de microscopia de luz, as características morfológicas da cortical e medular dos lóbulos tímicos individualizados destes cortes. Não foram observadas diferenças histológicas entre os sexos ou entre os grupos controle e tratado. Os resultados demonstraram que este antibiótico, utilizado em dose terapêutica e pelo período recomendado, não alterou a morfologia tímica dos animais tratados.

  1. Quimioterapia associada à terapia anti-retroviral de alta eficácia no tratamento dos linfomas não-Hodgkin agressivos relacionados à Síndrome da Imunodeficiência Adquirida Chemotherapy combined with highly active antiretroviral therapy for the treatment of aggressive AIDS related lymphomas

    OpenAIRE

    Juliana Pereira; Abrahão E Hallack Neto; Pracchia, Luís F; Andréa Alcântara; Beatriz B. Maurino; Pedro E. Dorliac-Llacer; Chamone, Dalton A. F.

    2004-01-01

    Linfoma não-Hodgkin é uma das complicações oncológicas mais freqüentes em portadores da Síndrome da Imunodeficiência Adquirida (AIDS). Em outros países, após a introdução da terapia anti-retroviral de alta atividade (HAART), a queda na incidência dos linfomas agressivos sistêmicos ficou aquém das expectativas, embora a sobrevida destes pacientes tenha triplicado. No Brasil, pouco se conhece a respeito do comportamento clínico e da sobrevida dos pacientes com linfoma e AIDS na era pós-HAART. O...

  2. Solubilidade de metais pesados em solos tratados com lodo de esgoto enriquecido

    OpenAIRE

    Oliveira, C.; N. M. B. Amaral Sobrinho; N. Mazur

    2003-01-01

    Os lodos de esgoto são materiais orgânicos ricos em nutrientes com potencial para o uso agrícola. A utilização desses materiais, no entanto, pode ser limitada pela presença de metais pesados na sua composição. Esta pesquisa teve por objetivos: (a) avaliar a solubilidade de Cd, Pb e Zn em dois tipos de solos tratados com lodo de esgoto enriquecido com esses metais; (b) verificar o efeito do tempo de contato nas mudanças da distribuição de Cd, Pb e Zn nas diferentes formas químicas de dois solo...

  3. Melanoma "in situ" tratado con Imiquimod Melanoma in situ treated with Imiquimod

    Directory of Open Access Journals (Sweden)

    RE Achenbach

    Full Text Available Comunicamos un caso con dos melanomas "in situ", en un varón de 86 años, localizados en ambos lados de la cara con alto riesgo quirúrgico, quien fuera tratado con imiquimod al 5% una vez al día durante dos meses; los resultados hasta el momento, clínicos e histológicos han sido satisfactorios.A 86 years-old man with two melanomas "in situ" at both sides of his face, treated with imiquimod 5% are presented. The patient has a cardiovascular high risk due to isquemic heart disease, for that reason we start the treatment with imiquimod once a day for two months. The clinical and histological response was good and a follow up will be as long as we can.

  4. Produção de moranga irrigada com esgoto doméstico tratado

    OpenAIRE

    Pedro C. P. de Oliveira; Thomas V. Gloaguen; Roberta A. B. Gonçalves; Dionei L. Santos

    2013-01-01

    Objetivou-se, neste trabalho, avaliar a produção de moranga (Cucurbita maxima Duch. Cv Coroa IAC) irrigada com esgoto doméstico tratado. O delineamento experimental foi em blocos casualizados com cinco tratamentos e quatro repetições. Os tratamentos se constituíram de : T1- irrigação com lâmina de 150% da demanda hídrica da cultura; T2- irrigação com lâmina de 150% + adição de CaSO4 no solo; T3- irrigação com lâmina de 100% da demanda hídrica da cultura; T4- irrigação com lâmina de 100% + adi...

  5. DERECHOS HUMANOS Y TRATADOS QUE LOS CONTIENEN EN EL DERECHO CONSTITUCIONAL Y LA JURISPRUDENCIA DE ECUADOR

    Directory of Open Access Journals (Sweden)

    Marco A. Morales Tobar

    2003-01-01

    Full Text Available El artículo analiza los derechos humanos en la Carta Fundamental del Ecuador y sus garantías, considerando la situación de los tratados internacionales en general y los derechos humanos en particular, estableciendo su procedimiento de incorporación, ubicando su posición entre las fuentes del derecho y considerando su aplicación por la jurisdicción constitucional ecuatoriana.The present article analizes Human Rights and their guarantees in the Constitution of Ecuador, considering the situation of international treaties in general and human rights in particular. Attention turns then to procedures for their incorporation, placing international treaties within the system of law and considering their application by the Ecuadorian constitutional jurisdiction.

  6. Presentación de 3 casos de hemangiomas infantiles tratados con propranolol

    Directory of Open Access Journals (Sweden)

    Edelisa Moredo Romo

    2011-09-01

    Full Text Available Los hemangiomas infantiles son los tumores vasculares benignos más frecuentes en la infancia, que ocurren mayormente en los pacientes pretérmino y en un 80 % afectan cabeza y cuello, con serias complicaciones hasta en un 20 % de los pacientes. Su ritmo evolutivo se caracteriza por una fase proliferativa y otra involutiva que pueden durar años. En la actualidad han sido utilizados los betabloqueadores, como el propranolol oral, con muy buenos resultados. Presentamos una serie de 3 casos de pacientes con hemangioma infantil atendidos en consulta de dermatología del Hospital Pediátrico Docente "Juan Manuel Márquez", tratados con propranolol de producción nacional por vía oral a 2 mg/kg/d en 2 subdosis con muy buenos resultados.

  7. Vinos, carnes, ferrocarriles y el Tratado de Libre Comercio entre Argentina y Chile (1905-1910

    Directory of Open Access Journals (Sweden)

    Pablo Lacoste

    2004-06-01

    Full Text Available Entre 1905 y 1910 Chile y Argentina negociaron la firma de un Tratado de Comercio con vistas a suprimir los aranceles aduaneros y consagrar el principio de "Cordillera Libre". El centro de atracción eran las exportaciones de ganado argentino a Chile y de vino chileno a Argentina. Pero en ambos países se produjo una fuerte reacción de los intereses creados con vistas a frustrar las tratativas diplomáticas. Tanto la Sociedad Nacional de Agricultura (Chile como el Centro Vitivinícola Nacional (Argentina realizaron intensas gestiones para alcanzar sus objetivos; esta última corporación llegó a movilizar miles de personas para oponerse al tratado; y hasta solicitó ayuda a los ferrocarriles británicos para que obstaculizaran el ingreso de los vinos chilenos al mercado argentino. La intensa resistencia de estas corporaciones terminaron por frustrar el proyecto, el cual fue definitivamente archivado en 1911.Between 1905 and 1910, Chile and Argentina negotiated the signature of a Trade Agreement in order to abolish the customs duties and consecrate the principle of "Free Mountain Range". The centre of attraction was the exports of Argentinean cattle to Chile and of Chilean wine to Argentina. But in both countries there aroused a strong reaction of the vested interests, purposely to thwart the diplomatic negotiations. Both, the Sociedad Nacional de Agricultura (Chile as well as the Centro Vitivinícola Nacional (Argentina carried out intense negotiations to reach their objectives; the latter even movilized thousands of people to oppose the treaty and went as far as requesting the help of the British railroads to block the entrance of Chilean wines to the Argentinean market. The stiff opposition of these corporations finally frustrated the project, which was definitively filed away in 1911.

  8. Chemical digestion and radionuclidic assay of TiNi-encapsulated 32P intravascular brachytherapy sources

    International Nuclear Information System (INIS)

    A very quantitative, destructive assay procedure was devised for accurately measuring the 32P activity content of TiNi-encapsulated intravascular brachytherapy sources and was applied to four different sources (termed 'seeds') which were developed and provided by Guidant Intravascular Intervention (formerly NeoCardia). These seeds are intended for use in the prophylactic treatment of restenosis following balloon angioplasty in heart-disease patients. The assays involved the dissolution of the TiNi jacket, extraction of the activity from the internal 32P-containing source material, quantitative solution transfers, and a gravimetrically-based dilution; followed by liquid scintillation (LS) spectrometry of the resulting master solution with 3H-standard efficiency tracing using composition-matched LS cocktails. The LS spectrometry utilized a previously-developed method for resolving the always-present 33P impurity. The protocol included provisions for accounting for all possible losses of 32P in the digestion procedure (based on radiochemical tracing experiments), for any unrecovered activity in the remaining source material, and for any residual activity in the solution-transfer and containing vessels. Sections of the TiNi jackets adjacent to the cut-off active seed portions were also assayed for any contained activity. Such destructive assays were required for relating measurements of the absorbed dose spatial distribution for the seeds to theoretic dose modelling and for establishing calibration factors for subsequent non-destructive radionuclidic measurements on the seeds

  9. Elimination of Bloodstream Infections Associated with Candida albicans Biofilm in Intravascular Catheters

    Directory of Open Access Journals (Sweden)

    Freshta Akbari

    2015-06-01

    Full Text Available Intravascular catheters are among the most commonly inserted medical devices and they are known to cause a large number of catheter related bloodstream infections (BSIs. Biofilms are associated with many chronic infections due to the aggregation of microorganisms. One of these organisms is the fungus Candida albicans. It has shown to be one of the leading causes of catheter-related BSIs. The presence of biofilm on intravascular catheters provide increased tolerance against antimicrobial treatments, thus alternative treatment strategies are sought. Traditionally, many strategies, such as application of combined antimicrobials, addition of antifungals, and removal of catheters, have been practiced, but they were not successful in eradicating BSIs. Since these fungal infections can result in significant morbidity, mortality, and increased healthcare cost, other promising preventive strategies, including antimicrobial lock therapy, chelating agents, alcohol, and biofilm disruptors, have been applied. In this review, current success and failure of these new approaches, and a comparison with the previous strategies are discussed in order to understand which preventative treatment is the most effective in controlling the catheter-related BSIs.

  10. Incompatibility of water soluble contrast media and intravascular pharmacologic agents: experimental study

    International Nuclear Information System (INIS)

    With the development of low osmolar and nonionic contrast media in clinical practice, radiologists have enjoyed increased clinical application along with other advantages such as improvement of patient comfort and safety. Recently, radiologists have introduced many intravascular pharmacologic agents to improve diagnostic quality and patient safety. Shortly after the introduction of these agents, however, it was observed that a precipitate results when a certain pharmacologic agent is mixed with a low osmolar contrast media. These observations have prompted testing of several other drugs used for incompatibility with contrast media. To verify these reports and to investigate other medications not previously tested, the authors analyzed mixtures of contrast agents and medications in vitro and observed them for visible precipitates after operating the high-speed centrifuge. The results were as fallows: The contrast media that produced incompatibilities with some pharmacologic agents were ioxaglate, diatrizote, and iothalamate in the order of frequency. The contrast media that produced no precipitate were iopromide and ioxithalamate. The pharmacologic agents that produced precipitate with some contrast media were Papaverine, Benadryl, Protamine, Cimetidine, Regitin, and Gentamicin. Therefore, we recommend that caution should be taken to recognize incompatibilities and avoid them when intravascular pharmacologic agents of any kind may be incompatible

  11. A Broadband Polyvinylidene Difluoride-Based Hydrophone with Integrated Readout Circuit for Intravascular Photoacoustic Imaging.

    Science.gov (United States)

    Daeichin, Verya; Chen, Chao; Ding, Qing; Wu, Min; Beurskens, Robert; Springeling, Geert; Noothout, Emile; Verweij, Martin D; van Dongen, Koen W A; Bosch, Johan G; van der Steen, Antonius F W; de Jong, Nico; Pertijs, Michiel; van Soest, Gijs

    2016-05-01

    Intravascular photoacoustic (IVPA) imaging can visualize the coronary atherosclerotic plaque composition on the basis of the optical absorption contrast. Most of the photoacoustic (PA) energy of human coronary plaque lipids was found to lie in the frequency band between 2 and 15 MHz requiring a very broadband transducer, especially if a combination with intravascular ultrasound is desired. We have developed a broadband polyvinylidene difluoride (PVDF) transducer (0.6 × 0.6 mm, 52 μm thick) with integrated electronics to match the low capacitance of such a small polyvinylidene difluoride element (<5 pF/mm(2)) with the high capacitive load of the long cable (∼100 pF/m). The new readout circuit provides an output voltage with a sensitivity of about 3.8 μV/Pa at 2.25 MHz. Its response is flat within 10 dB in the range 2 to 15 MHz. The root mean square (rms) output noise level is 259 μV over the entire bandwidth (1-20 MHz), resulting in a minimum detectable pressure of 30 Pa at 2.25 MHz. PMID:26856788

  12. Biodistribution of Neural Stem Cells After Intravascular Therapy for Hypoxic–Ischemia

    Science.gov (United States)

    Pendharkar, Arjun V.; Chua, Josh Y.; Andres, Robert H.; Wang, Nancy; Gaeta, Xavier; Wang, Hui; De, Abhijit; Choi, Raymond; Chen, Shawn; Rutt, Brian K.; Gambhir, Sanjiv S.; Guzman, Raphael

    2016-01-01

    Background and Purpose Intravascular transplantation of neural stem cells represents a minimally invasive therapeutic approach for the treatment of central nervous system diseases. The cellular biodistribution after intravascular injection needs to be analyzed to determine the ideal delivery modality. We studied the biodistribution and efficiency of targeted central nervous system delivery comparing intravenous and intra-arterial (IA) administration of neural stem cells after brain ischemia. Methods Mouse neural stem cells were transduced with a firefly luciferase reporter gene for bioluminescence imaging (BLI). Hypoxic–ischemia was induced in adult mice and reporter neural stem cells were transplanted IA or intravenous at 24 hours after brain ischemia. In vivo BLI was used to track transplanted cells up to 2 weeks after transplantation and ex vivo BLI was used to determine single organ biodistribution. Results Immediately after transplantation, BLI signal from the brain was 12 times higher in IA versus intravenous injected animals (Pcell survival outside the brain. Ex vivo single organ analysis showed a significantly higher BLI signal in the brain than in the lungs, liver, and kidneys at 1 week (Pstem cells in the ischemic brain in comparison to intravenous infusion. PMID:20616329

  13. Intravascular ultrasound catheter to enhance microbubble-based drug delivery via acoustic radiation force.

    Science.gov (United States)

    Kilroy, Joseph P; Klibanov, Alexander L; Wamhoff, Brian R; Hossack, John A

    2012-10-01

    Previous research has demonstrated that acoustic radiation force enhances intravascular microbubble adhesion to blood vessels in the presence of flow for moleculartargeted ultrasound imaging and drug delivery. A prototype acoustic radiation force intravascular ultrasound (ARFIVUS) catheter was designed and fabricated to displace a microbubble contrast agent in flow representative of conditions encountered in the human carotid artery. The prototype ARFIVUS transducer was designed to match the resonance frequency of 1.4- to 2.6-μm-diameter microbubbles modeled by an experimentally verified 1-D microbubble acoustic radiation force translation model. The transducer element was an elongated Navy Type I (hard) lead zirconate titanate (PZT) ceramic designed to operate at 3 MHz. Fabricated devices operated with center frequencies of 3.3 and 3.6 MHz with -6-dB fractional bandwidths of 55% and 50%, respectively. Microbubble translation velocities as high as 0.86 m/s were measured using a high-speed streak camera when insonating with the ARFIVUS transducer. Finally, the prototype was used to displace microbubbles in a flow phantom while imaging with a commercial 45-MHz imaging IVUS transducer. A sustained increase of 31 dB in average video intensity was measured following insonation with the ARFIVUS, indicating microbubble accumulation resulting from the application of acoustic radiation force. PMID:23143566

  14. Kasr El-Aini experience in radiation safety and quality management program in intravascular brachytherapy

    International Nuclear Information System (INIS)

    While simple, intravascular brachytherapy (IVB) presents a considerable potential for harm to the patient. The medical physicist maintains the responsibility to minimize the likelihood of operational problems or dosimetric errors. The principals for safe operation remain the same as with any radiotherapy treatment: to deliver the correct dose, to the correct location, safety. To develop an effective and comprehensive quality management QM program for IVB, a physicist should utilize proven risk assessment techniques rather than simply thinking of things to check, and follow guidances such as ISO9001:2000. Kasr El-Aini Hospital -Medical college-Cairo University installed intravascular Brach therapy treatment modality in 1999 so it was a must to proposed QM program includes the following: Procedures designed to assure the safety of the patient: Identification of the patient; tests of the integrity and patency for the delivery catheter, operation of the source train, and patency of the catheter in the treatment position; a check for recovery preparations; and verification of source recovery. Procedures to assure positional accuracy of the treatment: Verification of the positioning the catheter in the artery and of the sources in the catheter. Procedures to assure dosimetry accuracy: Acceptance testing of the device, including verification of the source strength and uniformity, and of the treatment duration tables; verification of the treatment prescription and duration for each patient; and control measures that minimize the likelihood of errors removing the source at the correct time. (author)

  15. Elimination of Bloodstream Infections Associated with Candida albicans Biofilm in Intravascular Catheters.

    Science.gov (United States)

    Akbari, Freshta; Kjellerup, Birthe Veno

    2015-01-01

    Intravascular catheters are among the most commonly inserted medical devices and they are known to cause a large number of catheter related bloodstream infections (BSIs). Biofilms are associated with many chronic infections due to the aggregation of microorganisms. One of these organisms is the fungus Candida albicans. It has shown to be one of the leading causes of catheter-related BSIs. The presence of biofilm on intravascular catheters provide increased tolerance against antimicrobial treatments, thus alternative treatment strategies are sought. Traditionally, many strategies, such as application of combined antimicrobials, addition of antifungals, and removal of catheters, have been practiced, but they were not successful in eradicating BSIs. Since these fungal infections can result in significant morbidity, mortality, and increased healthcare cost, other promising preventive strategies, including antimicrobial lock therapy, chelating agents, alcohol, and biofilm disruptors, have been applied. In this review, current success and failure of these new approaches, and a comparison with the previous strategies are discussed in order to understand which preventative treatment is the most effective in controlling the catheter-related BSIs. PMID:26131615

  16. Development of sup 1 sup 9 sup 2 Ir radiation sources for intravascular irradiation

    CERN Document Server

    Kogure, H; Iwamoto, S; Iwata, K; Kawauchi, Y; Nagata, Y; Sorita, T; Suzuki, K

    2003-01-01

    Intravascular brachytherapy is a novel therapy for preventing the restenosis of coronary artery by use of low-dose irradiation. JAERI and Kyoto University have been developing sup 1 sup 9 sup 2 Ir radiation sources by the cooperative research project entitled as 'The research on safety and effectiveness of the intravascular brachytherapy for preventing restenosis of the coronary artery disease' since 1998. The radiation source was introduced into the stenosis through a catheter (a guide-tube to insert directly into vascular) to irradiate the diseased part. Ten sup 1 sup 9 sup 2 Ir seed sources (phi 0.4 mm x 2.5 mm) were positioned between nylon spacers (phi 0.3 mm x 1.0 mm) in a flexible covering tube and the tube was plugged with a core-wire; the tube was shrunk to fix the inside materials and the size is 0.46 mm in diameter and 3 m in length. The physically optimal design was determined to insert the radiation source easily into vascular and to get the dose uniformity in the diseased part. The production me...

  17. “ STUDY OF COAGULATION PROFILE IN CLINICALLY DIAGNOSED CASES OF ACUTE DISSEMINATED INTRAVASCULAR COAGULATION USING ISTH CRITERIA

    Directory of Open Access Journals (Sweden)

    Chopade

    2013-10-01

    Full Text Available Disseminated Intravascular Coagulation (DIC is a pathological activation of coagulation (blood clotting mechanisms that happens in response to a variety of diseases. It involves the generation of intravascular fibrin (small blood c lots and the consumption of pro - coagulants and platelets. It results in the disruption of normal coagulation mechanism and abnormal bleeding occurs from the skin, the gastrointestinal tract, the respiratory tract and surgical wounds. It was the prospecti ve study of 60 patients of acute DIC, in which coagulation profile were studied from December 2010 to October 2012 . 40 controls were studied. Control group include healthy voluntary blood donors. The coagulation profile was studied and DIC scoring was p erformed using the International Society on Thrombosis and Haemostasis [ISTH] criteria. Among the coagulation profile, the sensitivity and specificity of the parameters to diagnose and to assess the severity of DIC, in the decreasing order of frequency wer e of platelet count, D - dimer, PT and APTT. Fibrinogen level was not depleted below the significant level (<1 gm/l in majority cases of DIC. According to the ISTH criteria, DIC scores among cases was ? 5.

  18. Intravascular large cell lymphoma: Clinicopathological and immunohistochemical description of a case

    Directory of Open Access Journals (Sweden)

    Dožić Branko

    2003-01-01

    Full Text Available A 51-year-old female patient was admitted to the Neurological clinic because of motor seizures with myoclonus of the right hand and right side of the face. The results of initial brain CT scan, chest X rays, EEG ultrasonography of the great blood vessels and laboratory tests made in another hospital were unremarkable. Because of repeated partial seizures transient aphasic disturbances, urinary sphincter disturbances and periodic low-grade fever the patient was transferred to our hospital four months after the disease onset. Laboratory tests and NMR suggested a nonspecific disseminated viral encephalitis. After administration of Endoxan she was ambulatory for several weeks and then became increasingly exhausted confused, febrile, dyspneic, tachypneic and developed a shock status with hepatorenal insufficiency. She died after 7 months of disease duration. Postmortem examination revealed intravascular collections of large atypical lymphoid cells of B cell line. Blood vessels changed in this way were common in the brain and rare in other organs including skin, lungs, heart, liver spleen and digestive system. They were not found in the lymph nodes and bone marrow. A biopsy was not done because of absence of symptomatic and swollen tissues. However, correlation of clinical feature and postmortem findings shows that absence of clinical manifestations in an organ does not mean lack of microscopic pathological changes and biopsy should be done regardless of absence of clinical signs. This case shows that intravascular lymphoma may mimic vasculitis or disseminated nonspecific viral encephalitis.

  19. Linfomas asociados a infección por virus de inmunodeficiencia humana en un complejo hospitalario de la Región Metropolitana, Chile: 1990-2002. Reporte de 14 casos y revisión Lymphomas and HIV infection in a reference hospital of Santiago, Chile: 1990-2002: Report of 14 cases and review

    Directory of Open Access Journals (Sweden)

    Guido Osorio S

    2007-04-01

    Full Text Available Se revisó la asociación de linfoma e infección por VIH en un complejo hospitalario de la Región Metropolitana Sur de Santiago de Chile, su incidencia, características clínicas y patológicas, terapia y evolución en 14 casos. La incidencia acumulada (enero 1990 y diciembre 2002 fue de 0,68%. Diez pacientes tenían linfoma no Hodgkin (siete de alto grado de malignidad y 50% en estadios III-IVB y cuatro Hodgkin (tres con celularidad mixta, dos en estadio IVB. Diez pacientes con linfoma estaban en etapa C3 de SIDA según criterios del CDC, con un promedio de CD4 de 139 células/mm³ y carga viral de 212.600 copias de ARN/ml. Ochenta y seis por ciento tenía afección ganglionar, localizada o generalizada. El tratamiento de los linfomas no Hodgkin de alto grado y extendidos fue con quimioterapia CHOP convencional, y en los linfomas de Hodgkin avanzados se aplicó el esquema ABVD. Seis pacientes recibieron tratamiento antiretroviral, cuatro simultáneamente con quimioterapia. La mortalidad global fue de 71%, por progresión tumoral y/o sepsis. Cuatro pacientes sobreviven (18 a 50 meses en remisión completa, dos linfomas no Hodgkin y dos Hodgkin. Se discuten la baja incidencia de la asociación linfoma y SIDA y la mayor frecuencia de linfomas con adenopatías localizadas o generalizadasThe association of HIV infection and lymphoma in patients attending at the South Health Metropolitan Reference Centre is presented. Objective: to analyse its incidence, clinical and pathologic manifestations, treatment and outcome. Period of study: January 1990 to December 2002. Results: 14 cases were detected, 10 non Hodgkin lymphoma patients (7 with high malignancy and 50 % in stages III-IVB and 4 with Hodgkin lymphoma (3 with mixed cellularity, 2 in stage IVB. The annual incidence was 0.68%. Ten patients were classified under stage C3 of AIDS CDC criteria, the mean CD4 count was 139 cells/mm³ and mean CV was 5,32 log. Eighty six percent of patients presented with unique or multiples lymphonodes, with predominance of advanced lymphoma stage. Conventional CHOP chemotherapy was the treatment for high risk and extended non Hodgkin lymphomas and for extended Hodgkin lymphomas the ABVD protocol was administered. Six patients received antiretroviral therapy, 4 simultaneously with chemotherapy. Global mortality in this series was 71%, attributable to tumor disease per se or to sepsis. Four patients survived (18 to 50 months in complete remission, 2 non Hodgkin lymphomas and 2 Hodgkin lymphomas. The low incidence of lymphoma and AIDS association and the high frequency of lymphomas with localized or generalized lymphonodes in this series are remarkable

  20. Intravascular Imaging

    Science.gov (United States)

    de Jong, Nico; Bom, Nicolaas; Schaar, Johannes; Goertz, David; Frijlink, Martijn; Steen, Anton Fw Van Der

    IVUS is used for diagnostics, therapy guidance and scientific purposes. It is the only clinical available technique that can assess plaque burden and free lumen diameter at high accuracy. Contrast angiography, which was the golden standard before IVUS, can only give a shadow projection of the lumen. Especially with the advent of 3D IVUS using pull backs it became an important tool for monitoring treatment and follow up of interventions like balloon angioplasty and placing of stents (wire prostheses that are used to prevent the arterial wall from recoiling). 3D IVUS in combination with biplane angiography allows assessment of true 3D reconstructions of arteries, pre and post treatment. Using computational fluid dynamics the velocity profile and thus the shear stress at the vascular wall can be calculated. This can be related to biological markers, which gives insight in formation of atherosclerosis, restenosis and remodelling.

  1. Multicenter assessment of the reproducibility of volumetric radiofrequency-based intravascular ultrasound measurements in coronary lesions that were consecutively stented

    DEFF Research Database (Denmark)

    Huisman, Jennifer; Egede, Rasmus; Rdzanek, Adam; Böse, Dirk; Erbel, Raimund; Kochman, Janusz; Jensen, Lisette Okkels; van der Palen, Job; Hartmann, Marc; Mintz, Gary S; von Birgelen, Clemens

    2012-01-01

    To assess in a multicenter design the between-center reproducibility of volumetric virtual histology intravascular ultrasound (VH-IVUS) measurements with a semi-automated, computer-assisted contour detection system in coronary lesions that were consecutively stented. To evaluate the reproducibility...

  2. Subacute fat-embolism-like syndrome following high-volume intramuscular and accidental intravascular injection of mineral oil

    DEFF Research Database (Denmark)

    Hjort, Mathias; Hoegberg, Lotte Christine Groth; Jansen, Tejs; Almind, Merete

    Objective. We present a rare case of subacute fat-embolism-like syndrome (FES-like) following intravascular injection of mineral oil-steroid solution with delayed diagnosis, acute onset of pulmonary distress, and transient clinical deterioration. Case report. A 40-year-old man was admitted...

  3. Intravascular ?-irradiation with a liquid 188Re-filled balloon for the prevention of restenosis in rabbit model

    International Nuclear Information System (INIS)

    Objective: To investigate the effects of intravascular ?-irradiation with a liquid 188Re-filled balloon on restenosis in rabbit model, and to evaluate the feasibility of the intravascular irradiation. Methods: The bilateral iliac arteries of 14 rabbits were injured by catheter balloon overdilation. A random side iliac artery of the rabbit was irradiated by a liquid 188Re-filled balloon with the radioactivity of 15 Gy at a depth of 0.5 mm beneath the skin close to the artery, and the other iliac artery served as a control. At 12 weeks after operation, quantitative angiography, histopathology and immunohistochemistry analysis were performed in the injured iliac arteries to evaluate the effects of irradiation. Results: There was significant increase in iliac artery diameter [(1.94 +- 0.19) vs (1.77 +- 0.28) mm, P2, P188Re-filled balloon irradiation group compared with control group. Conclusions: Intravascular ?-irradiation by a liquid 188Re-filled balloon with 15 Gy at 0.5 mm tissue depth beneath the skin close to the artery in rabbit model could inhibit neointimal proliferation and prevent restenosis. The intravascular brachytherapy with irradiation for prevention of restenosis is technically feasible

  4. Epidemiología y bioinformática en el estudio de la leucemia linfoma de células t del adulto asociada a la infección con vlht-1

    OpenAIRE

    Salcedo-Cifuentes, Mercedes; Restrepo, Oscar; García-Vallejo, Felipe

    2012-01-01

    Objetivos Establecer la relación entre el número de provirus VLHT-1 y las características de la cromatina adyacente en casos de Leucemia Linfoma de Células T del Adulto. Metodología Se realizó una revisión sistemática y un metaanálisis de la literatura publica que considero como variables de estudio los provirus por cromosoma y características estructurales y funcionales de la cromatina adyacente a los sitios de integración. La concordancia entre los resultados de la evaluación que emitieron ...

  5. HELICOBACTER PYLORI AND t(11;18)(q21;q21) TRANSLOCATION IN GASTRIC MALT LYMPHOMA / Helicobacter pylori e presença de translocação t(11;18)(q21;q21) em pacientes portadores de linfoma MALT gástrico

    Scientific Electronic Library Online (English)

    Karine Sampaio, LIMA; Walton, ALBUQUERQUE; Vitor Nunes, ARANTES; Ana Paula, DRUMMOND-LAGE; Luiz Gonzaga Vaz, COELHO.

    2014-04-01

    Full Text Available Contexto A patogênese do linfoma MALT (tecido linfoide associado à mucosa) gástrico, também conhecido como linfoma de zona marginal de células B, está claramente associada à gastrite por infecção pelo Helicobacter pylori e, a maioria desses tumores pode ser curada apenas com a erradicação da bactér [...] ia. A presença da translocação t(11;18)(q21;q21) tem sido identificada como a anomalia citogenética mais comum do linfoma MALT gástrico e sua presença pode prever uma menor taxa de resposta ao tratamento anti-H pylori. Objetivos Estudo da translocação genética t(11;18)(q21;q21) e seu impacto na evolução clínica de pacientes portadores de linfoma MALT gástrico de baixo grau. Métodos Uma série consecutiva de oito pacientes com linfoma MALT gástrico foi submetida à endoscopia digestiva, ultra-sonografia endoscópica, exame histopatológico, pesquisa do H pylori e metodologia rotineira de transcrição reversa seguida de reação em cadeia da polimerase (RT-PCR) utilizando primers específicos para API2-MALT1. Todos os pacientes receberam tratamento anti-H pylori e retratamento, quando necessário. Após a erradicação, exames endoscópicos foram realizados a cada 3-6 meses durante 2 anos para acompanhamento da evolução do tumor. Resultados Foram estudados oito pacientes (seis mulheres, idade média: 57 anos). Todos apresentavam à ecoendoscopia envolvimento tumoral restrito à mucosa ou submucosa com aparência endoscópica variável. A histologia mostrou que sete pacientes tinham linfoma MALT gástrico de baixo grau e um de alto grau. A erradicação do H pylori foi obtida em todos os pacientes, embora a bactéria não tenha sido identificada em um deles. Foi observada regressão histológica do tumor em 5/7 (71%) dos pacientes com linfoma MALT gástrico de baixo grau. A presença de t(11;18)(q21;q21) foi identificada em quatro (57%) destes pacientes; entre eles, dois apresentaram regressão histológica do tumor após erradicação do H pylori e os outros dois não apresentaram remissão do tumor, sendo encaminhados para tratamento oncológico suplementar. Conclusões A técnica de RT-PCR se mostrou reprodutível, factível e eficaz para detecção da t(11;18)(q21;q21), podendo ser realizada em poucos dias, em laboratórios de biologia molecular de rotina. A pesquisa da t(11;18)(q21;q21) em pacientes portadores de linfoma MALT gástrico é atualmente uma conduta bem estabelecida. A detecção precoce de tal translocação pode contribuir significativamente para a melhor definição da terapêutica a ser implementada aos portadores de linfoma MALT gástrico. Abstract in english Context Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is clearly associated with Helicobacter pylori gastritis and can be cured with anti- H pylori therapy alone. The presence of t(11;18)(q21;q21) translocation is thought to predict a lower response rate to anti- H pylori treatment. O [...] bjectives To study the presence of t(11;18)(q21;q21) genetic translocation and its clinical impact in low-grade gastric MALT lymphoma Brazilian patients. Methods A consecutive series of eight patients with gastric MALT lymphoma were submitted to gastroscopy, endoscopic ultrasound, histopathological examination, H pylori search and RT-PCR-based methodology. All patients received anti-H pylori treatment. Eradicated patients were followed-up every 3-6 months for 2 years. Results Eight patients were studied. All patients had tumor involvement restricted to the mucosa or submucosa and seven patients had low-grade gastric MALT lymphoma. All infected patients achieved H pylori eradication. Histological tumor regression was observed in 5/7 (71%) of the low-grade gastric MALT lymphoma patients. The presence of t(11;18)(q21;q21) translocation was found in 4 (57%) of these patients; among them only two had histological tumor regression following H pylori eradication. Conclusions RT-PCR is a feasible and efficient method to detect t(11;18)(q21;q21) translocation, being carried out in routine molecular biology la

  6. Células dendríticas foliculares: imunofenotipagem no linfoma de Hodgkin clássico esclerose nodular Dendritic follicular cells: immunophenotyping in classic Hodgkin’s lymphoma nodular sclerosis

    OpenAIRE

    Julieta M. M. F. Almeida; Maria H. Pitombeira; Sílvia M.M. Magalhães; Francisco D. Rocha Filho; Francisco V. A. Ferreira; Rosa M. S. Mota

    2006-01-01

    O linfoma de Hodgkin clássico esclerose nodular (LHCEN), de origem linfóide da célula B do centro germinativo (CG), apresenta agregados de células dendríticas foliculares (CDF), célula Hodgkin/Reed Sternberg e variantes, células B formando complexos relacionados ao CG, sugerindo uma associação entre esclerose nodular e formação do centro germinativo. O objetivo desse estudo foi avaliar a célula dendrítica folicular, por imunofenotipagem com o anticorpo fascina, em biópsia de linfonodo perifér...

  7. Non Hodgkin T cell lymphoma: an atypical clinical presentation Linfoma não Hodgkin de células T citotóxico: uma apresentação clínica atípica

    Directory of Open Access Journals (Sweden)

    Paula Maio

    2013-04-01

    Full Text Available Cytotoxic lymphomas comprise a spectrum of peripheral T-cell lymphomas that can have a initial or late cutaneous presentation. We describe a 46-year-old man from Cape Verde, with a dermatosis involving his face and trunk, consisting of monomorphic papules with a smooth surface and both motor and sensory polyneuropathy.The hypothesis of leprosy was supported by the clinical and initial hystopathological findings and the patient was referred to our hospital with suspected Hansen's disease. In the new skin and lymph node biopsies a lymphocyte population was identified whose immunohystochemistry study allowed the diagnosis of T-cell lymphoma with expression of cytotoxic markers. The patient was started on chemotherapy with initial remission of the skin lesions but, subsequently, progression of systemic disease.Os linfomas citotóxicos compreendem um espectro de linfomas de células T periféricos e linfomas Natural Killer que podem ter expressão cutânea primária ou secundária. Descrevemos o caso de um homem com 46 anos de idade, natural de Cabo Verde,com dermatose envolvendo a face e tronco constituída por pápulas monomorfas superfície lisa e polineuropatia sensitivo motora.A hipótese de Hanseníase foi colocada suportada por achados histopatológicos sugestivos sendo o doente referenciado à consulta de Doença de Hansen do nosso hospital. Em biopsia de pele e de gânglio identificou-se proliferação linfocitária cujo estudo imunohistoquímico permitiu o diagnóstico de linfoma T com expressão de marcadores citotóxicos. Iniciou quimioterapia verificando-se inicialmente remissão parcial das lesões cutâneas mas posteriormente a progressão da doença sistémica.

  8. Resistência ao tratamento no linfoma de Burkitt: associação com mutações específicas no gene TP53? Treatment resistance in Burkitt's lymphoma: is it associated with specific mutations of the TP53 gene?

    OpenAIRE

    Eliane P. S. Magluta; Klumb, Claudete E

    2008-01-01

    O linfoma de Burkitt (LB) surge a partir de uma célula do centro germinativo que perde o controle da proliferação devido à ativação do gene c-myc. A resistência à apoptose é uma causa importante da falha à quimioterapia na maioria dos cânceres e também no LB. A taxa alta de apoptose observada no LB em fases iniciais da gênese do tumor é seguida pelo desenvolvimento subseqüente de inativação de vias que levam à apoptose da célula. Uma importante via que se encontra alterada no LB é a via media...

  9. A utilidade da citologia por punção com agulha fina aliada a imunofenotipagem no diagnóstico dos linfomas não-Hodgkin Diagnosis of non-Hodgkin's lymphoma combining immunophenotyping and fine needle aspiration

    OpenAIRE

    Flávia P. S. Costa; Pereira, Fernanda G.; José Vassalo; Freitas, Leandro L. L.; Irene Lorand-Metze

    2005-01-01

    A classificação para linfomas não-Hodgkin (LNH) proposta pela Organização Mundial da Saúde (OMS) enfatiza a importância do imunofenótipo para o diagnóstico. O objetivo deste estudo foi avaliar a utilidade da citologia combinada a citometria de fluxo para o diagnóstico de LNH, utilizando um painel de anticorpos monoclonais e estudo do ciclo celular. O material foi obtido através de aspiração de linfonodos por agulha fina de 78 pacientes. O painel de anticorpos monoclonais para análise em citom...

  10. Monte Carol-Based Dosimetry of Beta-Emitters for Intravascular Brachytherapy; FINAL

    International Nuclear Information System (INIS)

    Monte Carlo simulations for radiation dosimetry and the experimental verifications of the simulations have been developed for the treatment geometry of intravascular brachytherapy, a form of radionuclide therapy for occluded coronary disease (restenosis). Monte Carlo code, MCNP4C, has been used to calculate the radiation dose from the encapsulated array of B-emitting seeds (Sr/Y-source train). Solid water phantoms have been fabricated to measure the dose on the radiochromic films that were exposed to the beta source train for both linear and curved coronary vessel geometries. While the dose difference for the 5-degree curved vessel at the prescription point of f+2.0 mm is within the 10% guideline set by the AAPM, however, the difference increased dramatically to 16.85% for the 10-degree case which requires additional adjustment for the acceptable dosimetry planning. The experimental dose measurements agree well with the simulation results

  11. The use of intravascular ultrasound for intraoperative assessment during semiclosed thromboendarterectomy

    DEFF Research Database (Denmark)

    Vogt, K C; Sillesen, H; Schroeder, T V

    1998-01-01

    To evaluate the application of intravascular ultrasound (IVUS) for intraoperative assessment of semiclosed thromboendarterectomy (TEA), IVUS images of the iliofemoral segment in 20 patients were obtained. The configuration and size of residual atherosclerotic material were evaluated. Stenoses in...... the artery proximal to the endarterectomized area were measured and, along with any remaining material, related to patency. Patency was evaluated at clinical controls after 3, 6, 12 and 24 months with duplex scanning and ankle-brachial index. In 10 cases (50%), material left behind from the...... endarterectomy was detected in the artery by IVUS. The material was removed in five cases. The part of the iliac artery proximal to the endarterectomized segment was visualized in 14 cases and showed minor stenoses in 10 cases. After follow-up at a median of 8 months (range 1-24), occlusion had occurred in one...

  12. Intravascular photoacoustic detection of vulnerable plaque based on constituent selected imaging

    Science.gov (United States)

    Zhang, Jian; Xing, Da

    2011-01-01

    Atherosclerosis, a disease of the large arteries, is the primary cause of heart disease and stroke. Over decades, atherosclerosis is characterized by thickening of the walls of the arteries, only advanced atherosclerotic disease could be observed. Photoacoustic imaging is a hybrid imaging technique that combines the advantages of high spatial resolution of ultrasound with contrast of optical absorption. In this paper, we present an intravascular photoacoustic (IVPA) imaging system to characterize vulnerable plaques by using the optical absorption contrast between different constituents. Epidemiological studies have revealed several important plaque constituents associated with early atherosclerosis, such as macrophage, cholesterol, lipid, calcification, and so on. We chose a section of lipid rich atherosclerosis artery and a section of normal artery as the phantom. Two IVPA images of them are given to show the difference between sick and normal. As a new method of detecting vulnerable plaque, IVPA constituents imaging will provide more details for diagnosis that offer an enticing prospect in early detecting of atherosclerosis.

  13. Intravascular papillary endothelial hyperplasia of the extremities: MR imaging findings with pathologic correlation

    International Nuclear Information System (INIS)

    We report the MRI findings of three cases of intravascular papillary endothelial hyperplasia (IPEH) of the extremities with correlation of the pathologic findings. The IPEH is a non-neoplastic reactive lesion within the vessels and is commonly associated with thrombi. Signal intensity of the IPEH is complex due to the thrombi and the PEH itself. The thrombi are characterized by a slightly hyperintense signal on T1- and T2-weighted images compared with that of muscle when it comes at the medium stage of hemorrhage. Papillary endothelial hyperplastic tissue appears either as iso- or hyperintense to the muscle on T2- and T1-weighted images and shows variable enhancement on Gd-DTPA-enhanced images. (orig.)

  14. Intravascular papillary endothelial hyperplasia of the extremities: MR imaging findings with pathologic correlation

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Sang Hoon [Department of Diagnostic Radiology, Brain Korea 21 project for Medical Science, Yonsei University College of Medicine, 132 Shinchondong, Seodaemoon-gu, 120-752, Seoul (Korea); Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea); Suh, Jin-Suck; Lim, Byung Il [Department of Diagnostic Radiology, Brain Korea 21 project for Medical Science, Yonsei University College of Medicine, 132 Shinchondong, Seodaemoon-gu, 120-752, Seoul (Korea); Yang, Woo Ick [Department of Pathology, Yonsei University College of Medicine, Seoul (Korea); Shin, Kyoo-Ho [Department of Orthopedic Surgery, Yonsei University College of Medicine, Seoul (Korea)

    2004-05-01

    We report the MRI findings of three cases of intravascular papillary endothelial hyperplasia (IPEH) of the extremities with correlation of the pathologic findings. The IPEH is a non-neoplastic reactive lesion within the vessels and is commonly associated with thrombi. Signal intensity of the IPEH is complex due to the thrombi and the PEH itself. The thrombi are characterized by a slightly hyperintense signal on T1- and T2-weighted images compared with that of muscle when it comes at the medium stage of hemorrhage. Papillary endothelial hyperplastic tissue appears either as iso- or hyperintense to the muscle on T2- and T1-weighted images and shows variable enhancement on Gd-DTPA-enhanced images. (orig.)

  15. Accurate 3D reconstruction of tortuous coronary vessels using biplane angiography and intravascular ultrasound

    Science.gov (United States)

    Prause, Guido P. M.; DeJong, Steven C.; McKay, Charles R.; Sonka, Milan

    1997-05-01

    At present, 3D reconstructions of coronary vessels are generated from intravascular ultrasound (IVUS) pullback sequences by stacking up ECG-gated segmented IVUS frames. Since this approach results in straight vessel reconstructions, it clearly fails in tortuous coronary arteries. This shortcoming may be overcome by data fusion with biplane angiography. The 3D course of the vessel is first derived from angiograms and then combined with segmented IVUS images in order to obtain a spatially correct and anatomically complete vessel reconstruction. In this paper, different approaches to two problems associated with the data fusion method are discussed: the definition of the pullback path and the estimation of IVUS catheter twist during pullback. A procedure for image acquisition, segmentation, mapping, and interpolation is proposed that has been designed with respect to its clinical applicability. In vitro validations of our previously reported algorithm for analytic catheter twist quantification is presented along with data fusion results of coronary arteries in cadaveric pig hearts.

  16. Automated calculation of the axial orientation of intravascular ultrasound images by fusion with biplane angiography

    Science.gov (United States)

    Wahle, Andreas; Prause, Guido P. M.; von Birgelen, Clemens; Erbel, Raimund; Sonka, Milan

    1999-05-01

    This paper presents an approach for fusion of the two major cardiovascular imaging modalities, angiography and intravascular ultrasound (IVUS). While the path of the IVUS catheter, which follows the vessel curvature during pullback, is reconstructed from biplane angiograms, cross-sectional information about the vessel is derived from IVUS. However, after mapping of the IVUS frames into their correct 3-D locations along the catheter path, their orientations remain ambiguous. We determine the relative catheter twisting analytically, followed by a statistical method for finding the absolute orientation from the out-of-center position of the IVUS catheter. Our results as obtained from studies with cadaveric pig hearts and from three patients undergoing routine coronary intervention showed a good match of the absolute orientation by the algorithm. In all tested cases, the method determined the visually correct orientations of the IVUS frames. Local distortions were reliably identified and discarded.

  17. The cerebral intravascular enhancement sign is not specific: a contrast-enhanced MRI study

    International Nuclear Information System (INIS)

    The intravascular enhancement (IVE) sign, also known as the ''arterial enhancement sign'', is an abnormal finding in the brain on contrast-enhanced MRI studies. IVE has been described in arterial cerebrovascular disorders, most commonly in acute or subacute arterial ischemic infarcts. However, the specificity of this sign has not been established. We describe four patients with disorders other than arterial strokes in whom gadolinium-enhanced high-field (1.5 T) MRI suggested IVE. The conditions were herpes simplex viral encephalitis, idiopathic cerebellitis, pneumococcal meningitis, and superior sagittal sinus thrombosis with venous infarction. IVE in these cases may be due to multiple factors, including arterial, venous, perivascular, and leptomeningeal or sulcal contrast medium accumulation. Our observations suggest that arterial ischemia, previously described as the cardinal cause of IVE, probably does not explain all instances, and urge caution in interpreting this sign as a specific MRI manifestation of acute arterial infarction or ischemia. (orig.)

  18. Intravascular low-intensity He-Ne laser irradiation therapy on idiopathic edema

    Science.gov (United States)

    Gao, Yunqing; Liu, T. C.; Tang, Xiang-Jun

    1998-11-01

    194 patients with psoriasis were treated by intravascular low level laser irradiation combined with Vit C 2.0g iv and O2 inhale to the nose. An hour once a day, for 5-40 times, and 13.06 times in average, ten times with 4-7 days intervals. The results: cured 23 cases, good effected 61 cases, improved 110 cases, relapsed 10 cases. Curative effect was related to treatment times, cured and good effected 5 times 12.5 percent, 10 times 31 percent, 15 times 94 percent. A matched control group in 17 patients was treated by drug. The results: good effected 1 case, improved 13 cases, not effected 3 cases.

  19. Comparison of angiography and intravascular ultrasound before and after balloon angioplasty of the femoropopliteal artery

    International Nuclear Information System (INIS)

    Purpose: To compare angiographic and intravascular ultrasound (IVUS) data before and after balloon angioplasty (PTA) of the femoropopliteal artery.Methods: Qualitative and quantitative analyses were performed on corresponding angiographic and IVUS levels obtained from 135 patients.Results: IVUS detected more lesions, calcified lesions, and vascular damage than angiography. Sensitivity of angiography was good for the presence of a lesion (84%), moderate for eccentric lesions (53%) and for vascular damage (52%), and poor for calcified lesions (30%). The increase in angiographic diameter stenosis was associated with a decrease in lumen area and increase in percentage area stenosis on IVUS.Conclusions: Angiography is less sensitive than IVUS for detecting lesion eccentricity, calcified lesions, and vascular damage. Presence of a lesion and amount of plaque were underestimated angiographically. Only before PTA was good agreement found between angiographic diameter stenosis and lumen size on IVUS.

  20. Comparison of Angiography and Intravascular Ultrasound Before and After Balloon Angioplasty of the Femoropopliteal Artery

    International Nuclear Information System (INIS)

    Purpose: To compare angiographic and intravascular ultrasound (IVUS) data before and after balloon angioplasty (PTA) of the femoropopliteal artery. Methods: Qualitative and quantitative analyses were performed on corresponding angiographic and IVUS levels obtained from 135 patients. Results: IVUS detected more lesions, calcified lesions, and vascular damage than angiography. Sensitivity of angiography was good for the presence of a lesion (84%), moderate for eccentric lesions (53%) and for vascular damage (52%), and poor for calcified lesions (30%). The increase in angiographic diameter stenosis was associated with a decrease in lumen area and increase in percentage area stenosis on IVUS. Conclusions: Angiography is less sensitive than IVUS for detecting lesion eccentricity, calcified lesions, and vascular damage. Presence of a lesion and amount of plaque were underestimated angiographically. Only before PTA was good agreement found between angiographic diameter stenosis and lumen size on IVUS

  1. Clinical value of intravascular ultrasound in diagnosing stent fracture: report of two cases with literature review

    International Nuclear Information System (INIS)

    Stent fracture has been implicated as a cause of drug-eluting stent failure. The authors report here 2 cases with stent fractures which were diagnosed by coronary artery angiography and intravascular ultrasound (IVUS). Both of them received multiple-stent-implantation. Five stent fractures altogether were detected in two patients. All the involved stents were sirolimus-eluting ones. Angiographic study showed that three stent fractures were complete transverse linear fracture with stent displacement. IVUS demonstrated that three stent fractures were complete break and two were partial break. One fracture was located close to the overlapping site of two stents and another fracture was accompanied by the formation of a coronary aneurysm. Angiography and IVUS are helpful to identify stent fracture. In addition, IVUS is more likely to clarify the cause of stent failure as well as the mechanism of stent fracture. (authors)

  2. [A blood speckle reduction method based on temporal-spatial relativity of intravascular ultrasound].

    Science.gov (United States)

    Dong, Haiyan; Wang, Huinan; Tao, Ling

    2006-12-01

    The superior imaging manner of intravascular ultrasound becomes more and more widely used in the diagnosis of coronary heart disease and intervention therapy. However, as the frequency of ultrasound increases, strong speckled echo signal from blood may significantly decrease the contrast of lumen and arterial wall structure, which may make it difficult for doctor to diferentiate and measure geometrical parameters and physical parameters of lumen and plaque. In this paper a novel noise reduction method is introduced, which utilizes the temporal and spatial information of IUVS, that is blood echo speckles have higher temporal and spatial variation than the arterial wall. When signals transferred into the frequency field, tissue and blood present different frequency spectrum, then a radio of high frequency energy and low frequency energy is introduced to determine speckles or tissue. Result showed that the method can remarkably remove the speckle noise, increase the contrast and help doctor differentiate the arterial wall from the around tissues. PMID:17228711

  3. Development of a Mechanical Scanning-type Intravascular Ultrasound System Using a Miniature Ultrasound Motor

    Science.gov (United States)

    Tanabe, Masayuki; Xie, Shangping; Tagawa, Norio; Moriya, Tadashi; Furukawa, Yuji

    2007-07-01

    Intravascular ultrasound (IVUS) plays an important role for the detection of arteriosclerosis, which causes the ischemic heart disease. In mechanical scanning-type IVUS, it is necessary to rotate a transducer or a reflecting mirror. A method that involves rotating the transducer using a torque wire causes image distortion (NURD: non uniform rotation distortion). For a method that involves placing an electromagnetic motor on the tip of an IVUS probe is difficult to miniaturize the probe. Our objectives are to miniaturize the probe (1 mm in diameter, 5 mm in length) and to remove NURD. Therefore, we conducted a study to assess the feasibility of attaining these objectives by constructing a prototype IVUS system, in which an ultrasound motor using a stator in the form of a helical coil (abbreviated as CS-USM: coiled stator-ultrasonic motor) is incorporated, and to clarify problems that need to be solved in constructing the probe.

  4. (100)-Textured KNN-based thick film with enhanced piezoelectric property for intravascular ultrasound imaging

    Science.gov (United States)

    Zhu, Benpeng; Zhang, Zhiqiang; Ma, Teng; Yang, Xiaofei; Li, Yongxiang; Shung, K. Kirk; Zhou, Qifa

    2015-04-01

    Using tape-casting technology, 35 μm free-standing (100)-textured Li doped KNN (KNLN) thick film was prepared by employing NaNbO3 (NN) as template. It exhibited similar piezoelectric behavior to lead containing materials: a longitudinal piezoelectric coefficient (d33) of ˜150 pm/V and an electromechanical coupling coefficient (kt) of 0.44. Based on this thick film, a 52 MHz side-looking miniature transducer with a bandwidth of 61.5% at -6 dB was built for Intravascular ultrasound (IVUS) imaging. In comparison with 40 MHz PMN-PT single crystal transducer, the rabbit aorta image had better resolution and higher noise-to-signal ratio, indicating that lead-free (100)-textured KNLN thick film may be suitable for IVUS (>50 MHz) imaging.

  5. Pressure-Flow Experimental Performance of New Intravascular Blood Pump Designs for Fontan Patients.

    Science.gov (United States)

    Chopski, Steven G; Fox, Carson S; Riddle, Michelle L; McKenna, Kelli L; Patel, Jay P; Rozolis, John T; Throckmorton, Amy L

    2016-03-01

    An intravascular axial flow pump is being developed as a mechanical cavopulmonary assist device for adolescent and adult patients with dysfunctional Fontan physiology. Coupling computational modeling with experimental evaluation of prototypic designs, this study examined the hydraulic performance of 11 impeller prototypes with blade stagger or twist angles varying from 100 to 600 degrees. A refined range of twisted blade angles between 300 and 400 degrees with 20-degree increments was then selected, and four additional geometries were constructed and hydraulically evaluated. The prototypes met performance expectations and produced 3-31?mm?Hg for flow rates of 1-5?L/min for 6000-8000?rpm. A regression analysis was completed with all characteristic coefficients contributing significantly (P?animal testing. PMID:26333131

  6. Disseminated intravascular coagulation in pregnancy: insights in pathophysiology, diagnosis and management.

    Science.gov (United States)

    Erez, Offer; Mastrolia, Salvatore Andrea; Thachil, Jecko

    2015-10-01

    Disseminated intravascular coagulation (DIC) is a life-threatening situation that can arise from a variety of obstetrical and nonobstetrical causes. Obstetrical DIC has been associated with a series of pregnancy complications including the following: (1) acute peripartum hemorrhage (uterine atony, cervical and vaginal lacerations, and uterine rupture); (2) placental abruption; (3) preeclampsia/eclampsia/hemolysis, elevated liver enzymes, and low platelet count syndrome; (4) retained stillbirth; (5) septic abortion and intrauterine infection; (6) amniotic fluid embolism; and (7) acute fatty liver of pregnancy. Prompt diagnosis and understanding of the underlying mechanisms of disease leading to this complication in essential for a favorable outcome. In recent years, novel diagnostic scores and treatment modalities along with bedside point-of-care tests were developed and may assist the clinician in the diagnosis and management of DIC. Team work and prompt treatment are essential for the successful management of patients with DIC. PMID:25840271

  7. Monte Carol-Based Dosimetry of Beta-Emitters for Intravascular Brachytherapy

    Energy Technology Data Exchange (ETDEWEB)

    Choi, C.K.

    2002-06-25

    Monte Carlo simulations for radiation dosimetry and the experimental verifications of the simulations have been developed for the treatment geometry of intravascular brachytherapy, a form of radionuclide therapy for occluded coronary disease (restenosis). Monte Carlo code, MCNP4C, has been used to calculate the radiation dose from the encapsulated array of B-emitting seeds (Sr/Y-source train). Solid water phantoms have been fabricated to measure the dose on the radiochromic films that were exposed to the beta source train for both linear and curved coronary vessel geometries. While the dose difference for the 5-degree curved vessel at the prescription point of f+2.0 mm is within the 10% guideline set by the AAPM, however, the difference increased dramatically to 16.85% for the 10-degree case which requires additional adjustment for the acceptable dosimetry planning. The experimental dose measurements agree well with the simulation results

  8. The cerebral intravascular enhancement sign is not specific: a contrast-enhanced MRI study

    Energy Technology Data Exchange (ETDEWEB)

    Bakshi, R.; Kinkel, W.R.; Bates, V.E.; Mechtler, L.L.; Kinkel, P.R. [Lucy Dent Imaging Center, University at Buffalo, NY (United States)

    1999-02-01

    The intravascular enhancement (IVE) sign, also known as the ``arterial enhancement sign``, is an abnormal finding in the brain on contrast-enhanced MRI studies. IVE has been described in arterial cerebrovascular disorders, most commonly in acute or subacute arterial ischemic infarcts. However, the specificity of this sign has not been established. We describe four patients with disorders other than arterial strokes in whom gadolinium-enhanced high-field (1.5 T) MRI suggested IVE. The conditions were herpes simplex viral encephalitis, idiopathic cerebellitis, pneumococcal meningitis, and superior sagittal sinus thrombosis with venous infarction. IVE in these cases may be due to multiple factors, including arterial, venous, perivascular, and leptomeningeal or sulcal contrast medium accumulation. Our observations suggest that arterial ischemia, previously described as the cardinal cause of IVE, probably does not explain all instances, and urge caution in interpreting this sign as a specific MRI manifestation of acute arterial infarction or ischemia. (orig.) With 4 figs., 1 tab., 44 refs.

  9. Percutaneous transluminal retrieval of intravascular iatrogenic foreign body by loop-snare technique

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Ik; Yoon, Yuo; Lim, Joo Won [Kyung Hee University College of Medicine, Seoul (Korea, Republic of)

    1993-09-15

    The use of intravacular catherterizastion for both diagnostic and therapeutic purpose increased the incidence of iatrogneic foreign bodies, which might cause many complications such as cardiac arrythmias, perforation of cardiac chamber or blood vessels, sepsis and thromboembolism. The authors experienced 5 cases of successful retrieval of intravascular iratrogenic foreign bodies: three cases of subclavian catheter wire and two cases of subclavian catheter. Subclavian catheter was introduce into right subclavian venous route for hyperalimenation or central venous pressure monitoring. The foreign bodies were located in superior vena cava and inferior vena cava in four cases and in left main pulmonary artery in the other case. We have successfully removed the foreign bodies by interventional procedures. The loop-snare technique is a safe and effective method for retrieval of iatrogenic foreign bodies in great vessels.

  10. Percutaneous transluminal retrieval of intravascular iatrogenic foreign body by loop-snare technique

    International Nuclear Information System (INIS)

    The use of intravacular catherterizastion for both diagnostic and therapeutic purpose increased the incidence of iatrogneic foreign bodies, which might cause many complications such as cardiac arrythmias, perforation of cardiac chamber or blood vessels, sepsis and thromboembolism. The authors experienced 5 cases of successful retrieval of intravascular iratrogenic foreign bodies: three cases of subclavian catheter wire and two cases of subclavian catheter. Subclavian catheter was introduce into right subclavian venous route for hyperalimenation or central venous pressure monitoring. The foreign bodies were located in superior vena cava and inferior vena cava in four cases and in left main pulmonary artery in the other case. We have successfully removed the foreign bodies by interventional procedures. The loop-snare technique is a safe and effective method for retrieval of iatrogenic foreign bodies in great vessels

  11. The cerebral intravascular enhancement sign is not specific: a contrast-enhanced MRI study.

    Science.gov (United States)

    Bakshi, R; Kinkel, W R; Bates, V E; Mechtler, L L; Kinkel, P R

    1999-02-01

    The intravascular enhancement (IVE) sign, also known as the "arterial enhancement sign", is an abnormal finding in the brain on contrast-enhanced MRI studies. IVE has been described in arterial cerebrovascular disorders, most commonly in acute or subacute arterial ischemic infarcts. However, the specificity of this sign has not been established. We describe four patients with disorders other than arterial strokes in whom gadolinium-enhanced high-field (1.5 T) MRI suggested IVE. The conditions were herpes simplex viral encephalitis, idiopathic cerebellitis, pneumococcal meningitis, and superior sagittal sinus thrombosis with venous infarction. IVE in these cases may be due to multiple factors, including arterial, venous, perivascular, and leptomeningeal or sulcal contrast medium accumulation. Our observations suggest that arterial ischemia, previously described as the cardinal cause of IVE, probably does not explain all instances, and urge caution in interpreting this sign as a specific MRI manifestation of acute arterial infarction or ischemia. PMID:10090599

  12. Clinical studies of intracranial lesions of disseminated intravascular coagulation syndrome by computerized tomography

    International Nuclear Information System (INIS)

    Six cases of intracranial hemorrhage associated with disseminated intravascular coagulation (DIC) syndrome were reported. Previously, intracranial hemorrhage was said to be much less frequent than cerebral infarction in DIC. However, intracranial hemorrhage was demonstrated in all of the 6 cases suffering from DIC who received computerized tomographic scanning. The high incidence of intracranial hemorrhage in this series was attributed to weakness of vascular wall which possibly resulted from primary intracranial diseases. Primary intracranial diseases existed in 3 cases: cerebrovascular disease, head injury, and meningitis. In complication with multiple organ failure, all of these patients expired. Aggressive treatment did not influence the outcome. Treatment of such cases should be early diagnosis and treatment of primary disease, which is likely to be the cause of DIC. (author)

  13. An automated approach for segmentation of intravascular ultrasound images based on parametric active contour models

    International Nuclear Information System (INIS)

    This paper presents a fully automated approach to detect the intima and media-adventitia borders in intravascular ultrasound images based on parametric active contour models. To detect the intima border, we compute a new image feature applying a combination of short-term autocorrelations calculated for the contour pixels. These feature values are employed to define an energy function of the active contour called normalized cumulative short-term autocorrelation. Exploiting this energy function, the intima border is separated accurately from the blood region contaminated by high speckle noise. To extract media-adventitia boundary, we define a new form of energy function based on edge, texture and spring forces for the active contour. Utilizing this active contour, the media-adventitia border is identified correctly even in presence of branch openings and calcifications. Experimental results indicate accuracy of the proposed methods. In addition, statistical analysis demonstrates high conformity between manual tracing and the results obtained by the proposed approaches.

  14. Neuroendocrine and renal effects of intravascular volume expansion in compensated heart failure

    DEFF Research Database (Denmark)

    Gabrielsen, A; Bie, P; Holstein-Rathlou, N H; Christensen, N J; Warberg, J; Dige-Petersen, H; Frandsen, E; Galatius, S; Pump, B; Sørensen, V B; Kastrup, J; Norsk, P

    2001-01-01

    To examine if the neuroendocrine link between volume sensing and renal function is preserved in compensated chronic heart failure [HF, ejection fraction 0.29 +/- 0.03 (mean +/- SE)] we tested the hypothesis that intravascular and central blood volume expansion by 3 h of water immersion (WI) elicits...... (by sustained angiotensin-converting enzyme inhibitor therapy, n = 9) absolute and fractional sodium excretion increased (P < 0.05) to the level of control subjects (108 +/- 34 micromol/min and 0.70 +/- 0.23%, respectively). Renal free water clearance increased during WI in control subjects but not in...... HF, albeit plasma vasopressin concentrations were similar in the two groups. In conclusion, the neuroendocrine link between volume sensing and renal sodium excretion is preserved in compensated HF. The natriuresis of WI is, however, modulated by the prevailing ANG II and Aldo concentrations. In...

  15. Leishmaniosis laríngea recidivante: un caso inusual en un paciente inmunocompetente tratado con corticoides Recidivant laryngeal leishmaniosis: an unusual case in an immunocompetent patient treated with corticosteroids

    Directory of Open Access Journals (Sweden)

    R. Casero

    2010-06-01

    Full Text Available La leishmaniosis es una parasitosis de evolución crónica; en Argentina, sus agentes etiológicos principales pertenecen al complejo Leishmania (Viannia braziliensis, habitualmente asociado a lesiones cutáneas y mucocutáneas. Informamos en este trabajo un caso de leishmaniosis laríngea en un hombre de 29 años procedente de Jujuy, quien a raíz de múltiples subdiagnósticos portaba esta parasitosis desde hacía 20 años. En el año 2008 este paciente consulta por disfonía crónica y trastornos en las vías aéreas superiores, refiere que fue sometido a terapias con tuberculostáticos, antifúngicos y corticoides desde 2002. Diferentes biopsias y fibroscopías revelaron los siguientes diagnósticos: laringitis granulomatosa inespecífica, laringitis compatible con tuberculosis, laringitis compatible con histoplasmosis, linfoma Natural Killer extraganglionar a células pequeñas. Finalmente, estudios realizados en nuestro hospital demostraron la presencia de una laringe granulomatosa en toda su extensión, amastigotes intra y extracelulares de Leishmania spp., ausencia de formas compatibles con Micobacterias e Histoplasma, y laringitis crónica vinculable a Leishmania spp. El paciente realizó tratamiento con antimoniato de N-metil-glucamina y demostró una muy buena evolución clínica tras ser examinado 2 meses después. Si bien la leishmaniosis laríngea como lesión única no es la presentación prevalente de esta zoonosis, su estudio amerita especial atención en pacientes tratados con corticoides, pues esto evitará un diagnóstico tardío y las mayores consecuencias asociadas a la morbimortalidad propia de esta parasitosis.Leishmaniosis is a chronic parasitic disease, which in Argentina is mainly caused by protozoa belonging to the Leishmania (Viannia braziliensis complex, leading to cutaneous and mucosal pathologies. We report a rare case of laryngeal leishmaniosis in a 29 year-old man from Jujuy province, Argentina, who had been misdiagnosed with other pathologies, carrying this infectious disease for about 20 years. During 2008, the patient was admitted with complaints of progressive hoarseness of the voice and dyspnea. He also reported having received tuberculostatics, antifungal and corticosteroids treatments since 2002. Different biopsies and direct laryngoscopic exams revealed inespecific granulomatous larynx, TBC-related laryngitis, laryngitis related to Histoplasma infection, extra-nodal Natural Killer-cell lymphoma. Finally, the patient was evaluated at the University Hospital and the final diagnosis was: granulomatous larynx, intra and extra-cytoplasmic Leishmania spp amastigotes, negative for TBC and Histoplasma cultures, and chronic laryngitis related to Leishmania infection, according to the laryngeal endoscopy, microbiological and histopathological exams, respectively. The patient received pentavalent antimonial treatment and his condition improved after 2 months of follow-up. Primary laryngeal leishmaniosis is rare and this localization does not belong to the most prevalent mucosal leishmaniosis. However, this parasitic disease warrants special concern, especially in patients who received prolonged corticosteroid treatments, in order to avoid a misdiagnosis of this disease.

  16. Penetration of an artificial arterial thromboembolism in a live animal using an intravascular therapeutic microrobot system.

    Science.gov (United States)

    Jeong, Semi; Choi, Hyunchul; Go, Gwangjun; Lee, Cheong; Lim, Kyung Seob; Sim, Doo Sun; Jeong, Myung Ho; Ko, Seong Young; Park, Jong-Oh; Park, Sukho

    2016-04-01

    The biomedical applications of wireless robots are an active area of study. In addition to moving to a target lesion, wireless locomotive robots can deliver a therapeutic drug for a specific disease. Thus, they hold great potential as therapeutic devices in blood vessel diseases, such as thrombi and occlusions, and in other diseases, such as cancer and inflammation. During a percutaneous coronary intervention (PCI), surgeons wear a heavy shielding cloth. However, they cannot escape severe radiation exposure owing to unstable shielding. They may also suffer from joint pains because of the weight of the shielding cloth. In addition, the catheters in PCIs are controlled by the surgeon's hand. Thus, they lack steering ability. A new intravascular therapeutic system is needed to address these problems in conventional PCIs. We developed an intravascular therapeutic microrobot system (ITMS) using an electromagnetic actuation (EMA) system with bi-plane X-ray devices that can remotely control a robot in blood vessels. Using this proposed ITMS, we demonstrated the locomotion of the robot in abdominal and iliac arteries of a live pig by the master-slave method. After producing an arterial thromboembolism in a live pig in a partial iliac artery, the robot moved to the target lesion and penetrated by specific motions (twisting and hammering) of the robot using the proposed ITMS. The results reveal that the proposed ITMS can realize stable locomotion (alignment and propulsion) of a robot in abdominal and iliac arteries of a live pig. This can be considered the first preclinical trial of the treatment of an artificial arterial thromboembolism by penetration of a blood clot. PMID:26857290

  17. Intravascular large B-cell lymphoma of the kidney: A case report

    Directory of Open Access Journals (Sweden)

    Jia Nan

    2011-09-01

    Full Text Available Abstract We report a 41-year-old Chinese woman with intravascular large B-cell lymphoma diagnosed by percutaneous renal biopsy. The patient was admitted to Nanfang Hospital of Southern Medical University, Guangzhou, China with complaints of high spiking fever for a month and bilateral lower limb fatigue with difficulty ambulating for the past 5 months. She had renal dysfunction with a total urinary protein of 5.61 g/dL (56.1 g/L, serum albumin of 2.89 g/dL (28.9 g/L, urea nitrogen of 2.24 mg/dL (1.6 mmol/L, and serum creatinine of 0.54 mg/dL (48 μmol/L. Bone marrow biopsy revealed myeloproliferative disorder without abnormal myeloid or lymphocytic proliferation. Positron Emission Tomography-Computed Tomography (PET-CT showed marked bilateral swelling and enlargement of the renal parenchyma with splenic enlargement and involvement of multiple vertebrae. Percutaneous renal biopsy showed island-like accumulations of medium to large lymphoid cells in many areas of the interstitium, with round vesicular nuclei containing distinct basophilic nucleoli. Immunohistochemical analysis together with other supportive investigation confirmed the diagnosis of intravascular large B-cell lymphoma. Ten days later, she was started on chemotherapy with CHOP (cyclophosphamide, doxorubicin, leurocristime and prednisone for a week. Palliative radiotherapy DT 40Gy/20F with other supportive treatment was provided for metastatic foci in the medullary cavity of the sternum, T1-T7. The patient regained muscle strength in both lower limbs and was able to walk again after three weeks. The patient was discharged after hepatic and renal function and proteinuria values had returned to normal. Follow-up data shows the patient to be alive nine months after discharge.

  18. New Intravascular Contrast Agent Applied to Dynamic Contrast Enhanced MR imaging of Human Breast Cancer

    International Nuclear Information System (INIS)

    Purpose: To evaluate the feasibility of using dynamic contrast-enhanced MR imaging with a new intravascular contrast agent in grading human breast cancer. Material and Methods: 23 patients with 27 breast tumors (21 carcinomas and 6 fibroadenomas) were examined with dynamic MR imaging after administration of Clariscan, an iron oxide nanoparticle with large T1 relaxivity and a long plasma half life. A 3D T1-weighted gradient echo sequence with an acquisition time of 60 s was repeated at regular intervals of 3-5 min before and up to 1 h after injection of 2 mg/kg b.w. of Clariscan. The endothelial transfer constant, Kps, which reflects overall vascular permeability, and the fractional plasma volume, fPV, were estimated from time-intensity curves acquired from three separate regions of interest (ROIs): whole tumor, a permeability hot spot, and a blood volume hot spot. Kps and fPV were compared to the results of histologic tumor grading (Scarff-Bloom-Richardson, SBR) and microvascular density, MVD. Results: A statistically significant correlation between the MR-derived Kps parameters and the SBR score was obtained for the whole tumor ROI (R = 0.70), and for the permeability hot spot ROIs (R = 0.67). A correlation between fPV and SBR was detected for the blood volume hot spot ROIs (R = 0.48). There was no statistically significant correlation between Kps or fPV with MVD. Conclusion: The results support the hypothesis that dynamic MR with the intravascular contrast agent Clariscan may be used for non-invasive tumor grading

  19. Linfomas plasmoblásticos del tracto gastrointestinal en pacientes con sida Plasmablastic lymphoma of the gastrointestinal tract in AIDS patients

    Directory of Open Access Journals (Sweden)

    Alejandro Avilés-Salas

    2011-12-01

    Full Text Available Los pacientes con infección por el virus de inmunodeficiencia humana (HIV tienen 200 veces más riesgo de desarrollar un linfoma no Hodgkin (LNH con respecto a la población general. El linfoma plasmoblástico (LP representa menos del 3% de todos los LNH asociados con el HIV. El objetivo de este estudio es informar las características clínico-patológicas de 5 pacientes con enfermedad HIV/sida y LP del tracto gastrointestinal. Se revisaron de forma retrospectiva los casos de LP del tracto gastrointestinal diagnosticados en el Instituto Nacional de Cancerología de la Ciudad de México en el periodo comprendido entre los años 2000 al 2009. Se analizaron las características clínico-patológicas y se realizaron cortes de bloques de tejidos embebidos en parafina para reacciones de inmunohistoquímica. La presencia del virus de Epstein Barr (VEB se examinó por reacción en cadena de la polimerasa (PCR in situ. De los cinco pacientes, cuatro fueron hombres y una mujer, con una mediana de edad de 29 años. Tres tumores se localizaron en la región anorrectal, uno en colon ascendente y el restante en el estómago. Histológicamente, todos los tumores se caracterizaron por una proliferación difusa de células grandes de aspecto plasmoblástico. Las células neoplásicas fueron CD 138/MUM-1 positivas y CD 20 / PAX-5 negativas. En cuatro pacientes se detectó el genoma del VEB en las células neoplásicas mediante PCR in situ. La mediana de seguimiento fue 18 meses; tres pacientes estaban vivos con enfermedad y dos sobreviven sin evidencias de la neoplasia. El diagnóstico precoz de LP como una entidad clínico-patológica es importante para establecer el tratamiento correcto y mejorar el pronóstico de estos pacientes.The risk of developing non-Hodgkin lymphoma (NHL is 200 times higher in HIV-positive patients than otherwise healthy persons. Plasmablastic lymphoma (PL represents < 3% of all NHL associated with HIV infection. The aim of this study was to review the clinical-pathologic features of PL of the gastrointestinal tract in 5 patients with HIV/aids disease. We performed a retrospective study of PL of the gastrointestinal tract diagnosed at the National Institute of Cancer at Mexico City, from 2000 to 2009. Clinical and pathological information was obtained and immunohistochemical studies were performed in paraffin-embedded tissue sections. The presence of Epstein-Barr Virus (EBV was examined by in situ polymerase chain reaction (PCR. Four male and 1 female were included with a median of age of 29 years. Three tumors involved the ano-rectal area, one tumor the ascendant colon and one tumor the stomach. All tumors were histologically characterized by a monotonous proliferation of large lymphoid cell with plasmablastic features. Tumor cells were CD 138 / MUM-1positive and CD 20 / PAX-5 negative in all cases. EVB genome was detected by in situ PCR in 4 cases. The median of follow-up was 18 months, and revealed that three patients are alive with neoplasm disease and two patients are still alive with no evidence of the neoplasm. Recognition of this entity by pathologists and clinicians is important in order to establish the correct diagnosis and the early treatment of these patients.

  20. Linfoma adrenal primário bilateral com envolvimento do sistema nervoso central: relato de caso Bilateral primary adrenal lymphoma with central nervous system involvement: a case report

    Directory of Open Access Journals (Sweden)

    Marcelo Souto Nacif

    2005-06-01

    Full Text Available Os autores demonstram os principais achados do linfoma adrenal primário nas tomografias computadorizadas (TC de abdome e crânio e na ressonância magnética (RM do crânio, apresentando um caso raro de um paciente do sexo masculino, 72 anos de idade, com progressiva deterioração do estado mental, evoluindo, num período de dois meses, com perda da memória recente, desorientação e, finalmente, franco quadro demencial. O paciente foi submetido a investigação por métodos de imagem com TC de crânio (sem administração venosa de contraste iodado, tórax e abdome (sem e com administração venosa de contraste iodado, e RM de crânio (antes e após a administração venosa de gadolínio. Na TC de crânio observaram-se áreas nodulares levemente hiperdensas, adjacentes aos ventrículos laterais. A TC de tórax não mostrou alterações relevantes. Na TC do abdome foram demonstrados nódulos sólidos em ambas as adrenais. A RM de crânio evidenciou impregnação difusa e nodular do epêndima do IV ventrículo, III ventrículo, cornos anteriores e temporais, átrios e corpo dos ventrículos laterais. O diagnóstico definitivo foi realizado através do estudo imuno-histoquímico da peça após biópsia da adrenal. Os autores concluíram, após revisão atualizada da literatura, que a TC e a RM são métodos essenciais na detecção e melhor avaliação de linfomas adrenais primários, principalmente quando associados a envolvimento do sistema nervoso central, e a RM mostra-se mais sensível para a detecção de lesões extracerebrais nos espaços epidural e subdural, principalmente após a administração venosa de gadolínio.The authors review the main findings of primary adrenal lymphoma on abdominal and brain computed tomography (CT scans and brain magnetic resonance imaging (MRI, and report a rare case of a 72-year-old male patient with deterioration in mental status progressing from recent memory loss to disorientation and ultimately dementia in a period of two months. The patient was investigated using imaging methods including brain (without intravenous administration of iodinated contrast media, chest and abdomen (pre and post intravenous administration of iodinated contrast media CT scans and brain MRI (pre and post intravenous administration of gadolinium. Brain CT scan showed slightly hyperdense nodules adjacent to the lateral ventricles. No gross abnormalities were seen on the chest CT scan. CT of the abdomen showed solid nodules on both adrenals. Brain MRI showed diffuse nodular enhancement of the ependyma of the fourth ventricle, third ventricle, frontal and temporal horns, atria and body of the lateral ventricles. Definitive diagnosis was made by immunohistochemical study of the biopsed adrenal. After a comprehensive review of the literature the authors concluded that CT and MRI are essential methods for the detection and accurate evaluation of primary adrenal lymphomas, particularly when there is involvement of the central nervous system. MRI is more sensitive in the detection of extracerebral lesions in the epidural and subdural spaces, especially after intravenous administration of gadolinium.

  1. Aspectos da tomografia computadorizada no linfoma em pacientes abaixo de 20 anos de idade Computed tomography findings in patients less than 20 years old with lymphoma

    Directory of Open Access Journals (Sweden)

    Adriana Moreira Viana Borba

    2007-04-01

    Full Text Available OBJETIVO: Descrever os achados gerais do linfoma em pacientes abaixo de 20 anos de idade e por subtipo histológico. MATERIAIS E MÉTODOS: Estudo retrospectivo do arquivo digital de tomografia computadorizada do Centro de Controle do Câncer do Hospital Universitário Pedro Ernesto da Universidade do Estado do Rio de Janeiro, no período de março de 2003 a julho de 2005. Dos 22 casos - 16 do sexo masculino e 6 do sexo feminino, com média de idade de 11,5 anos -, 12 eram do subtipo Hodgkin e 10 eram não-Hodgkin. RESULTADOS: Dos achados gerais, verificamos as linfonodomegalias mediastinais como o mais freqüente (59%, com predomínio no grupo Hodgkin (75%, seguido por hepatoesplenomegalia (50% e linfonodomegalias cervicais e retroperitoneais (27,3%. No subtipo Hodgkin houve predomínio do acometimento linfonodal, em sucessivas cadeias, seguido pela hepatoesplenomegalia (50%. Verificamos um caso de massa tonsilar unilateral, opacidade pulmonar em "vidro-fosco" e nódulos renais. No subtipo não-Hodgkin houve predomínio extranodal caracterizado por hepatoesplenomegalia (50%, espessamento de alça intestinal (40%, derrame pleural (30%, nódulo pulmonar (20%, ascite (10%, derrame pericárdico (10% e lesões ósseas mistas (10%. CONCLUSÃO: A tomografia computadorizada é de grande valia no diagnóstico, estadiamento e seguimento do linfoma, com achados de alerta como massa linfonodal, notadamente mediastinal, hepatoesplenomegalia, massa unilateral na tonsila e espessamento parietal de alça intestinal.OBJECTIVE: To describe the general findings of lymphoma and their histological patterns in patients less than 20 years old. MATERIALS AND METHODS: Twenty-two cases (16 male and 6 female, mean age 11.5 years from the digital archive of computed tomography at the Cancer Control Center of "Hospital Universitário Pedro Ernesto - Universidade do Estado do Rio de Janeiro", Rio de Janeiro, RJ, Brazil, were retrospectively analyzed in the period between March 2003 and July 2005. Of these 22 cases, 12 were Hodgkin's and 10 were non-Hodgkin's. RESULTS: Overall, mediastinal lymphadenomegaly was the most frequent finding (59%, with predominance in the Hodgkin's subgroup (75%, followed by hepatosplenomegaly (50% and cervical and retroperitoneal lymphadenomegaly (27.3%. The Hodgkin's subgroup presented a prevalence of lymphadenopathy, in many lymph node chains, followed by hepatosplenomegaly (50%. One case was found with unilateral tonsillar mass, pulmonary ground-glass opacities, and renal nodules. In the non-Hodgkin's subgroup, the disease was predominantly extranodal, characterized by hepatosplenomegaly (50%, thickening of the intestinal wall (40%, pleural effusion (30%, pulmonary nodule (20%, ascites (10%, pericardial effusion (10% and mixed bone lesions (10%. CONCLUSION: Computed tomography is an extremely useful method for detection, staging and follow-up of lymphomas, with alert findings like mediastinal lymphadenopathy, hepatosplenomegaly, unilateral tonsillar mass and thickening of intestinal wall.

  2. Linfoma cerebral primario: Efectividad y efectos secundarios del tratamiento oncoespecífico Primary brain lymphoma: Effectiveness and secondary effects of the oncospecific treatment

    Directory of Open Access Journals (Sweden)

    Roberto A. León González

    2006-06-01

    Full Text Available Se ha planteado que la efectividad de la quimioterapia para al tratamiento del linfoma primitivo del sistema nervioso central (LPSNC no es probada, no obstante, el tratamiento intravenoso e intratecal con methotrexate se ha utilizado y se han obtenido resultados satisfactorios. Se presentó el caso de un paciente, con el diagnóstico de LPSNC y una infiltración intraparenquimatosa en la región témporo-parietal izquierda al principio de la enfermedad y, posteriormente, en el ángulo pontocerebeloso homolateral. Se le aplicó tratamiento oncoespecífico, poliquimioterápico sistémico e intratecal y radioterapia holocraneal. Se observó desaparición de las lesiones reportadas en su totalidad, se logró evolución satisfactoria, aunque este paciente tuvo alteraciones severas tardías de sus funciones psíquicas superiores, con progresivos trastornos cognoscitivos y del comportamiento. Se pusieron en evidencia lesiones en el estudio imagenológico consistentes en atrofia cortical, leucoatrofia, sistema ventricular dilatado y áreas hiperintensas en la materia blanca del cerebro sin recurrencia tumoral. Se verificó el impacto positivo de la quimioterapia en el tratamiento del linfoma cerebral primario, así como la neurotoxicidad en el sistema nervioso central causada por el tratamiento oncoespecífico (radioterapia y quimioterapia. Se consideró que la radioterapia y la terapia combinada deben ser solamente utilizadas en los casos de recaídas. Se recomendó llevar a cabo un estudio clínico comparativo con valoraciones neuropsicológicas periódicas para determinar el posible efecto neurotóxico causado por la radioterapia y/o la quimioterapia. Desde el punto de vista clínico-imagenológico, el paciente presentó una leucoencefalopatía atrófica neurotóxica.It has been stated that the effectiveness of chemotherapy for the treatment of primary central nervous system lymphoma (PCNSL has not been proved; however, the intravenous or intrathecal treatment with methotrexate has been used and satisfactory results have been obtained. The case of a patient with diagnosis of PCNSL and an intraparenchymatous infiltration on the left temporoparietal region at the onset of the disease, and later on the homolateral pontocerebellar angle, is reported. Systemic and intrathecal oncospecific polychemotherapy and holocranial radiotherapy were applied. All the reported lesions disappeared, and a satisfactory evolution was observed, although this patient had severe late alterations of his higer psychical functions with progressive cognoscitive and behavorial disorders. Lesions such as cortical atrophy, leukoatrophy, dilated ventricular system, and hyperintensive areas in the white matter of the brain without tumoral recurrence were evidenced in the imaging study. The positive impact of chemotherapy on the treatment of primary brain lymphoma was verified, as well as the neurotoxicity in the central nervous system caused by the oncospecific treatment (radiotherapy and chemotherapy. It was considered that radiotherapy and combined therapy should be only used in relapses. It was recommended to conduct a comparative clinical study with periodical neuropsychological assessments to determine the posible neurotoxic effect caused by radiotherapy and chemotherapy. From the clinical and imaging point of view, the patient presented a neurotoxic atrophic leukoencephalopathy .

  3. Caracterización de factores pronósticos en pacientes con linfoma B difuso de células grandes / Characterization of prognostic factors to diagnosis of patients with diffuse large B cell lymphoma

    Scientific Electronic Library Online (English)

    Natalia María, Guevara; Patricia Elena, Jaramillo; Javier, Rendón; Lina María, Gaviria.

    2014-04-01

    Full Text Available Objetivo: describir los factores pronósticos demográficos, clínicos, hematológicos, inmunohistoquímicos y bioquímicos al diagnóstico de pacientes con linfoma B difuso de células grandes y su asociacióncon la severidad según el Índice Pronóstico Internacional en un Hospital Universitario, 2009-2012. [...] Métodos: se realizó un estudio descriptivo en 40 pacientes con dicho linfoma. Se comparó laconcentración de ?2 microglobulina con los factores pronósticos que componen el IPI y otros que nohacen parte; se determinó la asociación entre el IPI e IPI revisado y la concentración de ?2 microglobulina,infiltración medular, masa voluminosa y expresión de BCL-2 y Ki-67. La información se analizó en SPSS. Resultados: 40% de los pacientes pertenecían al grupo de riesgo alto según el IPI y 55% al grupocon pronóstico pobre según el IPI revisado; 82.5% expresaron BCL-2 y 61.5% tenían un Ki-67>70%.Se observó asociación entre la ?2 microglobulina y el Ann Arbor (p=0.036), la ?2 microglobulina y lainfiltración medular (p=0.003), y la ?2 microglobulina y el IPI revisado (p=0.037). Conclusiones: es probable que el tiempo transcurrido entre la aparición de los síntomas y eldiagnóstico haya favorecido que los pacientes se presentaran en estados avanzados de la enfermedady como consecuencia, con un pronóstico pobre. Así mismo, el estudio de la infiltración medular, elporcentaje de expresión de Ki-67 y la concentración de ?2 microglobulina favorece a la identificaciónde pacientes con un pronóstico adverso. (Acta Med Colomb 2014: 39: 137-147). Abstract in english Objective: to describe demographic, clinical, hematological, and immunohistochemical and biochemical prognostic factors to the diagnosis of patients with diffuse large B cell lymphoma and itsassociation with the severity according to the International Prognostic Index in a University Hospital,2009-2 [...] 012. Methods: a descriptive study was conducted in 40 patients with this lymphoma. ?2 microglobulinconcentration was compared with prognostic factors that compose the IPI and others which are not part of it; the association between IPI and revised IPI and ?2 microglobulin concentration, bone marrow infiltration, bulky mass and expression of BCL -2 and Ki p-67 was determined. Data was analyzed in SPSS. Results: 40% of the patients were in the high risk group according to IPI and 55% to the group with poor prognosis according to the revised IPI; 82.5% expressed BCL-2 and 61.5% had a Ki-67 > 70%. Association between ?2 microglobulin and Ann Arbor (p = 0.036), the ?2 microglobulin and bone marrow infiltration (p = 0.003), and ?2 microglobulin and revised IPI (p = 0.037) was observed. Conclusions: it is likely that the time between onset of symptoms and diagnosis has favored tha patients presented in advanced stages of the disease and as a result, with a poor prognosis. Likewise, the study of bone marrow infiltration, the percentage of Ki-67 expression and the concentration of ?2 microglobulin favors the identification of patients with an adverse prognosis. (Acta Med Colomb 2014: 39: 137-147).

  4. Partidos políticos Argentinos y Mercosur: Tratados Fundacionales y Comisión Parlamentaria Conjunta(1991-2006

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    Hugo Daniel Ramos

    2012-12-01

    Full Text Available El artículo intenta ofrecer algunas claves para el análisis de la relación entre partidos políticos argentinos y Mercosur centrando su atención en la esfera parlamentaria, ya sea a nivel nacional con la consideración de las discusiones de los "tratados fundacionales" de este proceso de integración, o a nivel regional con la exposición de elementos vinculados al trabajo desarrollado por la Comisión Parlamentaria Conjunta del Mercosur. En ambos casos se presta especial atención a la pertenencia partidaria de los legisladores, identificando su afiliación política y el posicionamiento que sustentan a lo largo del período bajo análisis.This article intends to offer some key points for the analysis of the Argentinian political parties and Mercosur relationship, mainly focusing on the parliamentary sphere, either at a national level, considering the discussions on the "foundation treaties" of this integration process, or at a regional level, through the presentation of elements related to the work developed by the Joint Parlamentary Commission of Mercosur. In both cases, special attention is paid to the legislators' party membership by identifying their political affiliation and the positioning they support throughout the analyzed period of time.

  5. INMIGRACIÓN Y EXTRANJERÍA. EN CAMINO HACIA EL TRATADO DE ÁMSTERDAM

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    Gabriele VESTRI

    2012-01-01

    Full Text Available A la luz de los recientes cambios político-democráticos de los países del mundo árabe, y no sólo, se pone una vez más sobre la mesa de debate el problema de la inmigración que cada vez más afecta los Estados europeos del sur. Si por un lado, España o Italia por su posición geográfica se identifican como las puertas de entrada hacia Europa, por el otro, todos los Estados miembros de la Unión Europea tienen que tomar consciencia del fenómeno y retomar aquellas pautas que ya en el pasado acercaron la Unión Europea al problema de la inmigración. El presente trabajo intenta recorrer este acercamiento que llevó, no sin problema, al Tratado de Ámsterdam. Muchas de las ideas de entonces pueden representar las bases de una nueva fase política en materia de inmigración.

  6. AVALIAÇÃO MORFOLÓGICA DO BAÇO DE COELHOS NOVA ZELÂNDIA BRANCO TRATADOS COM GENTAMICINA

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    GIRARDI, Annita Morais

    2014-06-01

    Full Text Available Considering the spleen importance for the immune system and the immunodepressive potential of gentamicin antibiotic, this study aimed to evaluate the effects of this aminoglycoside on the spleen histology of New Zealand White rabbits, male and female, after daily treatment with 4.4 mg kg-1 of gentamicin subcutaneously for seven days. It were analyzed, by light microscopy, the morphological characteristics of cortex and germinal center of white pulp splenic corpuscles, and the red pulp of this organ. The results showed that using just morphological analysis of this organ, it was not possible to detect any indicative signal that this antibiotic caused significant splenic changes in treated animals, when used in therapeutic dosage and by the recommended period. Considerando-se a importância do baço para o sistema imunológico e o potencial imunodepressor do antibiótico gentamicina, este estudo teve como objetivo avaliar os efeitos deste aminoglicosídeo sobre a histologia do baço de coelhos da raça Nova Zelândia Branco, machos e fêmeas, após tratamento diário com 4,4 mg kg-1 de gentamicina por via subcutânea, diariamente, durante sete dias. Foram analisadas, por meio de microscopia de luz, as características morfológicas da coroa e do centro germinativo dos corpúsculos esplênicos da polpa branca, além da polpa vermelha deste órgão. Os resultados demonstraram que, utilizando-se apenas a análise morfológica deste órgão, não foi possível detectar sinais indicativos de que este antibiótico, utilizado em dose terapêutica e pelo período recomendado, cause alterações esplênicas significativas nos animais tratados.

  7. El individuo ante la biopolítica: Tratado de Libre Comercio Colombia-EE.UU.

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    Martha Isabel Gómez Lee

    2009-11-01

    Full Text Available El problema de las patentes de biotecnología puede ser visto como un asunto de política de ciencia y tecnología, en la que el contexto de la globalización y de la sociedad del conocimiento cruza la política de la vida o biopolítica. En los Estados Unidos se considera un asunto de política pública del conocimiento, mientras que en Colombia es una cuestión de política social y ambiental. Los ciudadanos colombianos tienen mucho que decir y controlar en la revolución biotecnológica y comercial que redimensiona la extracción de renta de la tierra y reconfigura a la biodiversidad colombiana como nueva renta de germoplasma global. Los individuos están llamados a actuar de manera creativa en tres dimensiones: como agentes políticos y fuente de razones y acciones políticas, como objetivo último de las decisiones y las acciones de la biopolítica y como interfase entre las políticas públicas globales y las sociales. En esta última dimensión, el individuo colombiano es un actor político fundamental en las negociaciones del Tratado de Libre Comercio entre Estados Unidos y Colombia por ser él un actor activo de la sociedad civil en defensa de la vida.

  8. Hemangioma infantil tratado com propranolol Propranolol treatment for hemangioma of infancy

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    Flavia Kakiuti Bonini

    2011-08-01

    Full Text Available O hemangioma infantil é o tumor mais comum da infância, com grande variabilidade de apresentação clínica. A maioria das lesões regride espontaneamente e o tratamento está indicado para casos específicos que possam gerar ulceração, disfunção ou desfiguração. O tratamento baseia-se, principalmente, no uso de corticosteroides, seja por via sistêmica, tópica ou intralesional. Recentemente, o propranolol foi descrito como nova opção terapêutica para os hemangiomas, com resultados satisfatórios, permanentes e menos efeitos indesejáveis que os corticosteroides. É relatado o caso de uma criança com hemangioma periorbital e frontoparietal extenso, tratado com propranololInfantile hemangioma or hamangioma of infancy is the most common tumor in children, with great variability of presentation. Most cases resolve spontaneously and treatment is usually indicated for specific cases where injury has a high rate of morbidity or disfigurement after regression. The treatment is based on the use of systemic corticosteroids, which can also be used topically or by intralesional injections. Propranolol has been used recently as a new therapeutic option for the treatment of hemangiomas, with satisfactory, permanent results and fewer adverse effects than corticosteroids. This is a report of the case where a child presenting extensive periorbital and frontoparietal hemangioma was treated with propranolol

  9. Neumonías, reporte de dos casos tratados por homeopatía*

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    Jorge Luis Campistrous Lavaut

    1997-06-01

    Full Text Available Las neumonías son entidades que afectan al aparato respiratorio, especialmente al pulmón. Su tratamiento habitual es el uso de antibióticos y en ocasiones en cantidades abusivas. En el presente trabajo se describen dos casos que fueron tratados por homeopatía y en los cuales no fue necesario el uso de los antibióticos. Ambas pacientes habían padecido de bronconeumonía en 3 ocasiones anteriores. A las 2 pacientes se les indicó tratamiento con Phosphoro 6 CH durante 1 mes consecutivo a razón de 5 gotas 3 veces al día, y su respuesta fue favorable al tratamiento, al concluir éste se le dio el medicamento de fondo. Hace 6 meses que padecieron la neumonía y se mantienen asintomáticas.Pneumonias are diseases affecting the respiratory system, specially the lungs. Its habitual treatment consists in the use of antibiotics, which are sometimes excessively used. In this paper we describe 2 cases that are treated by homeopathy with no need of antibiotics. Both patients had suffered from bronchopneumonia 3 times before. They were treated with 5 drops of Phosphorus 6 CH 3 times a day during a month and the response was favorable. On concluding the treatment, they continued taking drugs. These subjects suffered from pneumonia 6 months ago and they are still asymptomatic.

  10. Alterações oxidativas (cor e lipídios em presunto de peru tratado por Alta Pressão Hidrostática (APH

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    Simone Pereira Mathias

    2010-12-01

    Full Text Available A Alta Pressão Hidrostática (APH consiste em uma tecnologia inovadora de processamento de alimentos com utilização de pressões elevadas (100 a 900 MPa que possui vantagens em relação às tecnologias térmicas convencionais, pois mantém as características sensoriais do alimento próximas do original e garante segurança do ponto de vista microbiológico, por prolongado período de vida útil. No presente estudo, foi avaliada a aplicação de alta pressão a presunto de peru nos processos oxidativos, em particular na oxidação de lipídios e os efeitos na cor do produto, quando tratados a pressões de 200 a 400 MPa, por 5, 10 e 15 minutos em temperatura ambiente. Dos resultados obtidos, pode-se observar que não foram verificadas diferenças significativas (p > 0,05 entre amostras controle e pressurizada para o índice de TBA e índice de peróxido. Foi observado também alteração da cor decorrente de reações oxidativas aos 45 e 65 dias de armazenamento em amostras tratadas com pressões de 400 MPa a 5 e 15 minutos

  11. Criptosporidiosis experimental en ratones albinos tratados con Metilprednisolona Experimental Cryptosporidiosis in Albino Mice Treated with Methylprednisolone

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    María del P Hurtado

    2010-12-01

    Full Text Available Cryptosporidium spp., es un coccidio intracelular de distribución mundial responsable de un síndrome entérico en el hospedador inmunocompetente e inmunocomprometido. Se estudio la influencia inmunosupresora de la metilprednisolona (MP en la evolución de la criptoporidiosis experimental en ratones de laboratorio. Se utilizaron dos grupos de cuatro ratones machos jóvenes cada uno; el primer grupo incluyó cuatro ratones infectados y tratados en forma interdiaria con MP a dosis de 16 mg/kg de peso durante cuatro semanas y el segundo grupo (control cuatro ratones infectados y no tratados. El inóculo fue preparado a partir de Cryptosporidium spp. obtenido de un paciente con criptosporidiosis intestinal, administrando un volumen de 0,1 mL a través de una sonda oro-esofágica. Cada semana, se recogieron muestras de heces para realizar diagnóstico de criptosporidiosis intestinal mediante la coloración de Kinyoun. Se estudió la diseminación visceral del parásito tomando semanalmente un animal de cada grupo para necropsia, obteniéndose muestras de cada órgano para estudio histopatológico. Las formas parasitarias observadas, en tejidos, fueron como sigue: ooquistes, esporozoítos falciformes, formas sexuales, merozoítos libres y trofozoítos. Durante las cuatro semanas de estudio, la forma parasitaria predominante fue la de merozoíto libre. Se observó diseminación tisular en tráquea, glándula tiroides, intestino, bazo y ganglio linfático. No se observó el parásito en esófago, hígado, riñón y pulmón. En el grupo control la presencia del parásito se mantuvo limitada al intestino. La supervivencia de los animales fue del 100% en ambos grupos durante el período de estudio. La respuesta observada en los animales tratados con MP se expresó de manera evidente en la diseminación tisular del parásito en órganos distintos del aparato digestivo, efecto no demostrado en los animales infectados y no tratados. Sin embargo, el número total de formas parasitarias cuantificadas, no presentó diferencias notables durante las cuatro semanas que duró el experimento, pero si pudo demostrar que no es necesario un alto grado de inmunosupresión para que Criptosporidium spp. produzca formas extra-intestinales de la criptosporidiosis.Cryptosporidium spp. is an intracellular coccidium distributed worlwide, which is responsible for an enteric syndrome in the immunoincompetent and immunocompromised host. This investigation was conducted to study the immunosuppressing influence of methylprednisolone (MP during the course of experimental cryptosporidiosis in albino mice. A total of eight young male albino mice were studied and alloted into two groups: Group I: four infected mice treated every other day with a oral dose of 16 mg/kg of body weight of MP given through a stomach tube for four weeks; Group II (Control Group: four infected but untreated mice. A volume of 0.1 mL of an inoculum prepared from Cryptosporidium spp., obtained from stools of a patient with enteric cryptosporidiosis was given via a stomach tube. Every week, stool samples were collected for a diagnosis of intestinal cryptosporidiosis using the Kinyoun staining. The visceral dissemination of the parasite was studied by sampling weekly one animal of each group, and obtaining necropsy samples of each organ for histopathological examination. The parasitic forms observed in tissues were as follows: oocysts, falciform sporozoites, sexual forms, free merozoites, and trophozoites. The parasitic forms that prevailed during the experiment were the free merozoites. Parasitic dissemination to trachea, thyroid gland, intestine, spleen, and lymphatic ganglion was seen. In contrast, the parasite was not observed in esophagus, liver, kidneys and lungs. In Group II, the presence of the parasite was confined to the intestines. Mice survival was 100% for both groups during the study period.The results show that the observed response of animals treated with MP was evident with the parasite dissemination in organs other than the digestive tract, effect not shown in animals from Group II. Nonetheless, the total number of parasitic forms did not show overt differences during the duration of the experiment, although it was demonstrated that a high degree of immunosupression is not required to allow for the Cryptosporidium spp. dissemination in the extraintestinal forms of this disease.

  12. Linfoma no Hodgkin tipo anaplásico de localización cutánea: Presentación de 1 caso

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    María Dolores Castillo Menéndez

    2003-03-01

    Full Text Available Se describió un caso de linfoma maligno no Hodgkin tipo anaplásico (LMnH, de localización principal en la piel de la región torácica posterior de un paciente de 56 años de edad, masculino, raza negra, proveniente de la provincia de Manica, Mozambique. El cuadro lesional y topográfico hizo pensar en otros tipos de tumores o micosis profundas. Se corroboró el diagnóstico de LMnH tipo anaplásico de grandes células, CD 30+, por la histología, inmunocitoquímica y la inmunohistoquímica. Se inició el tratamiento con poliquimioterapia, CHOP (ciclofosfamida, doxorrubicina, vincristina y prednisona, 6 ciclos con intervalos de 3 semanas entre ellos. Se logró evolución satisfactoria, la totalidad de las lesiones dermatológicas involucionaron. Actualmente, se encuentra en observación.The case of a 56-year-old black male patient from the province of Manica, Mozambique, that presented an anaplastic malignant non-Hodgkin’s lymphoma mainly located in the skin of the posterior thoracic region, was described. The lesion and topographic picture made us think about other types of tumors or deep mycosis. The diagnosis of CD 30+ anaplastic malignant large-cell non-Hodgkin’s lymphoma was corroborated by histology, immunocytochemistry and immunohistochemistry. The treatment was initiated with combination chemotherapy, CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone, 6 cycles at intervals of 3 weeks among them. A satisfactory evolution was attained. It was observed an involution of all the skin lesions. At present, this patient is under observation.

  13. Linfoma subcutâneo de células T paniculite-símile Subcutaneous panniculitis-like T-cell lymphoma

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    Renato Soriani Paschoal

    2009-08-01

    Full Text Available Linfoma subcutâneo de células T paniculite-símile foi recentemente reconhecido como entidade clínico-patológica. Paciente do sexo feminino, 17 anos, relatou nodosidades eritêmato-violáceas e depressões nos membros e abdome há três anos e discreta perda ponderal, sem outros sintomas gerais. Adenomegalia, visceromegalias e infiltração da medula óssea estavam ausentes, e a histopatologia da pele mostrou densa infiltração de linfócitos atípicos CD3/CD8 no subcutâneo. A quimioterapia interrompeu o surgimento de novas lesões com remissão das pré-existentes no seguimento de oito meses. Aspectos imunofenotípicos e moleculares são relevantes para elucidação diagnóstica e avaliação do prognóstico.Subcutaneous panniculitis-like T-cell lymphoma is extremely rare and has recently been recognized as a clinicopathological entity. Young female, 17 years old, has complained of subcutaneous nodules and plaques in the limbs and abdomen for three years, accompanied of mild weight loss without other constitutional symptoms. Nodal, visceral and bone marrow involvement was absent, and subcutaneous CD3/CD8 atypical lymphocyte infiltration was observed in the skin sample. Chemotherapy interrupted the onset of new lesions and led to remission in the 8-month follow-up. Immunophenotypic and molecular aspects were relevant to the diagnosis and as prognosis makers.

  14. Derecho aplicable al fondo de la controversia en arbitrajes surgidos de tratados de inversión

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    Francisco Endara Flores

    2011-07-01

    Full Text Available En este trabajo se analizará cuál es el derecho aplicable al fondo de la controversia de un arbitraje surgido de un Tratado de Inversiones. A lo largo del artículo se tratará de demostrar que la fuente primaria aplicable al fondo de la controversia, será el mismo Tratado de Inversión, seguido por un análisis del rol que tendrá el derecho local al momento de resolver la controversia.Lo mismo se hará respecto al resto de normas del derecho internacional y la manera en como dichas normas se integran para ser aplicadas por los árbitros al momento de resolver la controversia.

  15. El tratado de Ottawa: de la base a la cima en la agenda internacional ¿una institución multilateral al estilo clásico?

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    Mercé Aguilar Antón

    2010-08-01

    Full Text Available El Tratado de Ottawa es un hito en la historia del multilateralismo. Por primera vez, miles de organizaciones no gubernamentales, la ONU y la Cruz Roja , de manera coordinada, llamaron la atención a los gobiernos del mundo sobre la necesidad de poner fin al uso de las Minas Antipersona (MAP, un arma de guerra que ha causado mutilaciones, muertes y sufrimiento a millones de personas. El objetivo de este trabajo es analizar el proceso desde la base y mostrar cómo el tema surgió hasta convertirse en un asunto de interés internacional, así como examinar el Tratado de Ottawa a la luz de los preceptos de los teóricos Ruggie (Anatomía de una institución multilateral y Keohane (legitimidad y determinar qué tanto se aproxima a una institución multilateral de tipo clásico.

  16. La conferencia de petrópolis y el tratado interamericano de asistencia recíproca en río de janeiro en 1947

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    Caicedo Castilla, José Joaquín

    2010-01-01

    Capítulo I: 1. Origen del Acta de Chapultepec; 2. El acta de Chapultepec; 3. Convocatoria de una nueva conferencia; 4. Gobiernos asistentes. Capítulo II -- Crónica de la conferencia: 1. Sesión inaugural; 2. Organización de la conferencia; 3. El debate general. Capítulo III -- Preámbulo del tratado: 1. Relaciones entre la ONU y el Panamericanismo; 2. Principios de Derecho Internacional; 3. Antecedentes; 4. El proyecto colombiano; 5. Política de paz; 6. La protección internacional de los derech...

  17. ALTERAÇÕES ELETROQUÍMICAS E DINÂMICA DE NUTRIENTES NA SOLUÇÃO DO SOLO EM ARROZ IRRIGADO COM LIXIVIADO INDUSTRIAL TRATADO

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    Filipe Selau Carlos

    2015-04-01

    Full Text Available A utilização de efluentes industriais tratados na irrigação do arroz por alagamento pode provocar alterações eletroquímicas e aumentar o teor de nutrientes na solução do solo. Para testar essa hipótese, este trabalho teve por objetivo avaliar a dinâmica dos atributos químicos e eletroquímicos da solução do solo sob cultivo de arroz irrigado com lixiviado industrial tratado, contendo 820 mg L-1 de Na. O experimento foi conduzido em casa de vegetação, utilizando-se como unidades experimentais vasos preenchidos com 20 kg de solo, em delineamento experimental em blocos casualizados, com três repetições. Os tratamentos foram: controle (irrigação com água destilada e quatro proporções do lixiviado (25, 50, 75 e 100 %. As coletas de solução do solo foram feitas semanalmente a partir do quarto dia após o início do alagamento (DAA até 84 DAA. A solução do solo foi amostrada na profundidade de 10 cm e analisada para os principais nutrientes e o Na, bem como para a demanda bioquímica de oxigênio (DBO5, relação de adsorção de sódio (RAS, condutividade elétrica (CE e potencial redox (EH. A irrigação com o lixiviado aumentou os teores de K, Ca, Mg, S, P, N-NH+4, N-NO?3 e Na, assim como os valores de RAS e CE, para valores considerados prejudiciais para as plantas. Foi observada diminuição do potencial redox na solução do solo pela irrigação com lixiviado industrial tratado. Os teores de DBO5 e o N-NH+4 diminuíram com o tempo de alagamento. Em proporções menores que 25 %, o lixiviado industrial tratado pode aumentar os teores de nutrientes em solução sem causar interferência do Na para as plantas.

  18. Staphylococcus warneri meningitis in a patient with Strongyloides stercoralis hyperinfection and lymphoma: first report of a case Staphylococcus warneri meningite em paciente com hiperinfecção com Strongyloides stercoralis e linfoma: primeiro relato de caso

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    Renzo Nino Incani

    2010-06-01

    Full Text Available A case of meningitis due to Staphylococcus warneri in a patient with a hyperinfection with Strongyloides stercoralis possibly associated with rituximab treatment for mantel cell lymphoma is reported for the first time in the literature. The patient was a 59-year-old woman, with a 3-year history of an apparently well controlled lymphoma after treatment with chemotherapy-immunotherapy and then immunotherapy alone, and diagnosis of strongyloidiasis. Meningitis was diagnosed by cerebrospinal fluid culture and tested with an automated plate system. The patient was successfully treated with vancomycin; although fever and productive cough persisted. Severe gastrointestinal symptoms and pneumonia developed three weeks later. Hyperinfection syndrome by S. stercoralis was diagnosed, with abundant larvae in feces and expectoration.Caso de meningite por Staphylococcus warneri em paciente com hiperinfecção com Strongyloides stercoralis, possivelmente associada com tratamento de rituximab para linfoma de células do manto é relatada pela primeira vez na literatura. A paciente, mulher de 59 anos com história de três anos de linfoma aparentemente bem controlado com tratamento com quimioterapia-imunoterapia e, em seguida, somente imunoterapia e diagnóstico de estrongiloidíase. Meningite foi diagnosticada por cultura do líquido cefalorraquidiano e testada com sistema automatizado de placa. A paciente foi tratada com sucesso com vancomicina, embora a febre e a tosse produtiva não tenham desaparecido. Após graves sintomas gastrointestinais a paciente desenvolveu pneumonia três semanas mais tarde. Síndrome de hiperinfecção por S. stercoralis foi diagnosticada, com larvas abundantes nas fezes e expectoração.

  19. Avaliação morfológica e imuno-histoquímica de linfomas gástricos primários Morphologic and immunohistochemical evaluation of primary gastric lymphomas

    Directory of Open Access Journals (Sweden)

    Jorge Alberto Thomé

    2005-04-01

    Full Text Available INTRODUÇÃO: Os linfomas gástricos primários representam cerca de 50% dos linfomas não-Hodgkin extranodais e de 2% a 8% das neoplasias malignas do estômago. A maioria é formada pela proliferação de linfócitos B, que ocorre a partir do tecido linfóide associado à mucosa. Esse tecido, inexistente no estômago em condições normais, surge como conseqüência de gastrite crônica, na maioria das vezes associada à bactéria Helicobacter pylori. A inflamação crônica provocada pela infecção bacteriana parece sensibilizar linfócitos T, levando a estímulo constante de linfócitos B, que passam a proliferar inicialmente em padrão reacional. Posteriormente surgem alterações genômicas nessas células, que provocam ganho proliferativo, seleção clonal e transformação neoplásica, dando origem a linfoma de baixo grau. Alterações genéticas adicionais, como mutações em p53, podem induzir transformação para alto grau. MATERIAL E MÉTODOS: Foram estudados 32 casos de linfomas gástricos: 15 de baixo e 17 de alto grau. Foram investigados sexo e idade dos pacientes, características morfológicas das lesões,índice de proliferação celular e colonização pelo Helicobacter pylori. Verificou-se a expressão de CD20, Ki-67, p53, BCL-2 e BCL-6 por imuno-histoquímica. RESULTADOS: Os linfomas gástricos ocorreram mais freqüentemente em homens, e a faixa etária mais elevada foi observada no grupo de baixo grau. Lesões linfoepiteliais foram observadas em 93% dos linfomas desse grupo. O índice de proliferação celular e a expressão do p53 foram mais elevados no grupo de alto grau. A expressão do BCL-2 foi mais elevada nos linfomas de baixo grau. Não houve diferença significante quanto à expressão do BCL-6 nos dois grupos. CONCLUSÃO: Os resultados sugerem a participação dos genes p53 e BCL-2 na patogênese e na evolução dos linfomas gástricos.INTRODUCTION: Primary gastric lymphomas account for 50% of the extranodal non-Hodgkin lymphoma and for 2% to 8% of the malignant gastric neoplasms. Most of them arise from B lymphocytes proliferation of the mucosaassociated lymphoid tissue. This tissue is not present in stomach in normal conditions; it arises secondarily to chronic gastritis, frequently associated to the bacterium Helicobacter pylori. Chronic inflammation of the bacterium infection seems to induce T lymphocytes, leading to persistent stimulation of B lymphocytes that initially proliferate in a reactive fashion. After that, there are some genomic changes in the lymphoid cells, including BCL-2 and BCL-6 mutation inducing some proliferating gain, clonal selection and neoplastic transformation, originating the lowgrade gastric lymphoma. Additional genetic changes, like p53 mutation, can induce high-grade transformation. MATERIAL AND METHODS: We revised 32 cases of gastric lymphomas: 15 low and 17 high-grade. The age and the gender of those patients were investigated. The morphological characteristics of the lesions and Helicobacter pylori colonization were assessed. Immunohistochemistry to CD20, Ki-67, p53, BCL-2 and BCL-6 was performed. RESULTS: Gastric lymphomas occur more frequently in males and patients' age is more advanced in the low grade group. Lymphoepithelial lesions were observed in 93% of this lymphoma group. The proliferative rate and p53 expression were greater in the high grade group. The BCL-2 expression was higher in the low grade lymphoma group. There were no significant differences in BCL-6 expression in both groups. CONCLUSION: The results suggest that genes P53 and BCL-2 play a role in the pathogenesis and evolution of gastric lymphomas.

  20. Linfoma de Burkitt primario de la cavidad oral en una paciente con sida: reporte de un caso y revisión de la literatura / Burkitt's lymphoma of the oral cavity in a female with AIDS: case report and literature review

    Scientific Electronic Library Online (English)

    Marcelo, Corti; María Florencia, Villafañe; Mario, Valerga; Ricardo, Sforza; Alicia, Bistmans; Marina, Narbaitz.

    2015-03-01

    Full Text Available Los linfomas no Hodgkin (LNH) son un grupo heterogéneo de enfermedades linfoproliferativas con elevada prevalencia en pacientes infectados por el virus de la inmunodeficiencia humana (VIH). La inmunodeficiencia asociada al sida predispone al desarrollo de LNH, incluyendo el linfoma de Burkitt (LB). [...] El LB es un subtipo infrecuente y agresivo de LNH con elevada frecuencia en pacientes con sida. Se asocia a una alta tasa de replicación celular (determinada por el índice Ki67) y con alta frecuencia de compromiso extranodal como forma de presentación clínica de la neoplasia. Se presenta una paciente con sida que desarrolló un LB primario de la cavidad oral y se realiza una revisión de la literatura sobre el tema. Abstract in english Non-Hodgkin lymphomas (NHL) are a heterogeneous group of diseases with a high prevalence in human immunodeficiency virus (HIV) infected patients. The immunosuppression associated with AIDS predisposes to develop NHL, including Burkitt's lymphoma (BL). BL is an uncommon and aggressive subtype of NHL [...] that occurs with increased frequency among patients with AIDS. BL is associated with a high proliferative rate (Ki67 index) and compromises extranodal sites as the clinical presentation of the disease. Here we report a case of a primary BL of the oral cavity in an AIDS female patient, and a review the literature on the characteristics of oral cavity lymphomas in AIDS patients.

  1. Legitimidad y finalidad de los capítulos de propiedad intelectual en los tratados de libre comercio (TLC

    Directory of Open Access Journals (Sweden)

    Susy Frankel

    2011-11-01

    Full Text Available Una visión analítica de la realidad actual permite apreciar un auge de los Tratados de Libre Comercio, mientras se presenta un estancamiento en las negociaciones multilaterales de comercio. Si bien la negociación de los TLC no se limita a los países desarrollados, los negociados por los países en desarrollo no tienden a contemplar mejoras en los estándares de propiedad intelectual. Algunos de los capítulos relativos a la propiedad intelectual incluidos en los Tratados de Libre Comercio simplemente reafirman los estándares del acuerdo sobre los ADPIC, mientras que otros se orientan a ampliar el cubrimiento y alcance de los derechos internacionales de propiedad intelectual. El presente artículo se concentra en estudiar la legitimidad y la finalidad de los capítulos de propiedad intelectual en los Tratados de Libre Comercio, así como la relación entre los capítulos sobre propiedad intelectual y el sistema multilateral de la Organización Mundial del Comercio (OMC que facilita los TLC y los límites racionales de la propiedad intelectual en el contexto comercial.

  2. Radial dose function of a 90Sr 90Y seed in water and A150: Comment on Calibration and characterization of beta-particle sources for intravascular brachytherapy

    OpenAIRE

    Asenjo, J.; Fernández Varea, José María; Sánchez-Reyes, A.; Wang, C.-K.

    2002-01-01

    Intravascular brachytherapy with beta sources has become a useful technique to prevent restenosis after cardiovascular intervention. In particular, the Beta-Cath high-dose-rate system, manufactured by Novoste Corporation, is a commercially available 90Sr 90Y source for intravascular brachytherapy that is achieving widespread use. Its dosimetric characterization has attracted considerable attention in recent years. Unfortunately, the short ranges of the emitted beta particles and the associate...

  3. Solubilidade de metais pesados em solos tratados com lodo de esgoto enriquecido

    Directory of Open Access Journals (Sweden)

    C. Oliveira

    2003-02-01

    Full Text Available Os lodos de esgoto são materiais orgânicos ricos em nutrientes com potencial para o uso agrícola. A utilização desses materiais, no entanto, pode ser limitada pela presença de metais pesados na sua composição. Esta pesquisa teve por objetivos: (a avaliar a solubilidade de Cd, Pb e Zn em dois tipos de solos tratados com lodo de esgoto enriquecido com esses metais; (b verificar o efeito do tempo de contato nas mudanças da distribuição de Cd, Pb e Zn nas diferentes formas químicas de dois solos tratados com lodo de esgoto enriquecido com esses metais; (c verificar a influência das frações inorgânicas e orgânicas do lodo na dinâmica destes metais no solo. O enriquecimento do lodo de esgoto consistiu em adicionar Cd, Pb e Zn a um lodo de esgoto urbano produzido na Estação de Tratamento da Ilha do Governador (ETIG, Rio de Janeiro (RJ. Após 20 dias de incubação, sob umidade constante (50 % g g-1, o lodo enriquecido foi utilizado para a instalação de experimentos em amostras de duas classes de solos: Latossolo Vermelho-Amarelo (LV e Argissolo Vermelho-Amarelo (PV. Em laboratório, as amostras dos solos foram incubadas com quantidades equivalentes a 0; 20; 40 e 80 t ha-1 de lodo de esgoto enriquecido. Nos tempos de contato solo-lodo enriquecido de 4, 12, 16, 24 e 160 semanas, amostras de solos foram retiradas e submetidas à extração seqüencial de Cd, Pb e Zn. Observou-se, através da extração seqüencial, que compostos orgânicos solúveis formaram complexos, principalmente com cádmio e zinco, mantendo teores elevados destes elementos associados à fração solúvel em água durante todo o período experimental. A incorporação de compostos inorgânicos de Fe e Mn, através do lodo de esgoto, permitiu que o Cd, Pb e Zn se ligassem em sua maior parte, à fração extraível com hidroxilamina. Com o tempo de incubação, observou-se decréscimo dessa fração com aumento da fração residual, indicando decréscimo na solubilidade destes elementos, com o passar do tempo, reduzindo os riscos de contaminação.

  4. Estabilización de los indicadores hematológicos en paciente con policitemia absoluta secundaria tratado con Vimang

    Directory of Open Access Journals (Sweden)

    Gregorio Martínez-Sánchez

    2009-04-01

    Full Text Available Se reporta un caso del sexo masculino, de 72 años de edad con antecedentes de hipertensión arterial (con un período de evolución de 5 años que fue remitido en el 2001 a la Consulta de Hematología por presentar cifras elevadas de hemoglobina (Hb y hematócrito (Hto. Las cifras elevadas de Hb y Hto se detectaron durante un chequeo médico como resultado de que el paciente presentara pérdida de conocimiento y fuera hospitalizado. El paciente se remitió al Instituto de Hematología e Inmunología (Ciudad de La Habana para realizarle un estudio de volemia y ferrocinética, el cual mostró que presentaba policitemia absoluta moderada. Se descartó policitemia vera y se buscaron causas de policitemia absoluta secundaria sin que hayan encontrado ninguna hasta el presente. Desde este momento el paciente se ha seguido en la Consulta de Hematología del Hospital General Docente Ernesto Che Guevara (Las Tunas y cada 6 meses es chequeado en el Instituto de Hematología e Inmunología, Ciudad de La Habana. A partir del mes de abril de 2004 el paciente recibió 600 mg de Vimang® (extracto de Mangifera indica L. y se incrementó 2 meses después a 900 mg en 3 dosis separadas de 300 mg (tabletas diariamente. El presente estudio analizó la historia clínica del paciente y los resultados de todos los estudios que se le practicaron en los años precedentes al tratamiento con Vimang® y los observados durante el año que estaba bajo tratamiento. Como resultado se observó una reducción en un 50 % del número de flebotomías necesarias para mantener el paciente bajo control con respecto a los valores de Hto y Hb. Se encontraron además diferencias significativas (p < 0,05 con respecto a las desviaciones estándar de los indicadores Hto y Hb, que fueron menores en el periodo en que el paciente fue tratado con el extracto natural.

  5. 3D dosimetry study of 188Re liquid balloon for intravascular brachytherapy using BANG polymer gel dosemeters

    International Nuclear Information System (INIS)

    It has been suggested that the combination of intravascular brachytherapy and coronary stent implantation may result in further reduction of restenosis after percutaneous balloon angioplasty. The use of an angioplasty balloon filled with a P188Re liquid beta source for intravascular brachytherapy provides the advantage of accurate source positioning and uniform dose distribution to the coronary vessel wall. The effect of source edge and stent on the dose distribution of the target tissue may be clinically important. In BANG gels, the absorbed radiation produces free-radical chain polymerisation of acrylic monomers that are initially dissolved in the gel. The number of polymer particles is proportional to the absorbed dose. In this study, 3D dose distributions are presented for 188Re balloons, with and without stents, using a prototype He-Ne laser CT scanner and the proprietary BANG polymer gel dosemeters. (author)

  6. Atrial Fibrillation Pacing Decreases Intravascular Shear Stress in a New Zealand White Rabbit Model: Implications in Endothelial Function

    OpenAIRE

    Jen, Nelson; Yu, Fei; Lee, Juhyun; Wasmund, Steve; Dai, Xiaohu; Chen, Christina; Chawareeyawong, Pai; Yang, Yongmo; Li, Rongsong; Hamdan, Mohamed H.; Hsiai, Tzung

    2012-01-01

    Atrial fibrillation (AF) is characterized by multiple rapid and irregular atrial depolarization leading to rapid ventricular responses exceeding 100 beats per minute (bpm). We hypothesized that rapid and irregular pacing reduced intravascular shear stress (ISS) with implication to modulating endothelial responses. To simulate AF, we paced the left atrial appendage of New Zealand White (NZW) rabbits (n=4) at rapid and irregular intervals. Surface electrical cardiograms (ECG) were recorded for ...

  7. Adult-onset Still’s disease with disseminated intravascular coagulation and hemophagocytic syndrome: a case report

    OpenAIRE

    Mimura, Tetsuhiko; Shimodaira, Masanori; Kibata, Minoru; Tsukadaira, Akihiro; Shirahata, Kumiko

    2014-01-01

    Background Adult-onset Still’s disease is a rare inflammatory condition of unknown origin characterized by high spiking fever, arthralgia, arthritis, myalgia, salmon-colored evanescent rash, and hepatosplenomegaly. The diagnosis of adult-onset Still’s disease requires the exclusion of other possible disorders because it lacks specific clinical and histopathological findings. Adult-onset Still’s disease rarely become fatal due to visceral involvements such as disseminated intravascular coagula...

  8. An unusual case of an ulcerative colitis flare resulting in disseminated intravascular coagulopathy and a bladder hematoma: a case report

    OpenAIRE

    Christie Dennis; Murray Karen; Suskind David L

    2004-01-01

    Abstract Background Disorders of coagulation have long been associated with inflammatory bowel disease. Children, as well as adults, with both active and inactive ulcerative colitis have been found to have abnormal coagulation and fibrinolysis. Disseminated intravascular coagulation arises from an overwhelming of the haemostatic regulatory mechanisms leading to an excessive generation of thrombin and a failure of the normal inhibitory pathways to prevent systemic effects of this enzyme. Ulcer...

  9. Effects of intravascular volume expansion on the cardiovascular response to naloxone in a canine model of severe endotoxin shock.

    OpenAIRE

    Evans, S. F.; Hinds, C J; Varley, J. G.

    1984-01-01

    The specific opiate receptor antagonist, naloxone, can produce haemodynamic improvement and increased survival in experimental shock. The efficacy of naloxone therapy in a canine model of endotoxin shock has been evaluated both with and without intravascular volume replacement. Animals were anaesthetized with alpha-chloralose and allowed to breathe spontaneously. A large bolus dose of endotoxin was followed by a continuous infusion and treatment was instituted one hour after the endotoxin bol...

  10. Prothrombin Time, Activated Partial Thromboplastin Time, Fibrinogen, dan D-dimer Sebagai Prediktor Decompensated Disseminated Intravascular Coagulation Sisseminated pada Sepsis

    OpenAIRE

    Fenny; Nadjwa Zamalek Dalimoenthe; Noormartany; Emmy Pranggono; Nina Susana Dewi

    2011-01-01

    Sepsis is a systemic response to infection especially in pneumonia case. Sepsis can cause complications such as disseminated intravascular coagulation (DIC) which can be divided into compensated and decompensated DIC. The purpose of this study was to assess whether the value of prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen, and D-dimer levels can be used as predictors of decompensated DIC in sepsis patients. This study was conducted at the Laboratory of Clini...

  11. A randomized, controlled, multicenter trial of the effects of antithrombin on disseminated intravascular coagulation in patients with sepsis

    OpenAIRE

    Gando, Satoshi; Saitoh, Daizoh; Ishikura, Hiroyasu; Ueyama, Masashi; Otomo, Yasuhiro; Shigeto ODA; Kushimoto, Shigeki; Tanjoh, Katsuhisa; Mayumi, Toshihiko; Ikeda, Toshiaki; Iba, Toshiaki; Eguchi, Yutaka; Okamoto, Kohji; Ogura, Hiroshi; Koseki, Kazuhide

    2013-01-01

    Introduction To test the hypothesis that the administration of antithrombin concentrate improves disseminated intravascular coagulation (DIC), resulting in recovery from DIC and better outcomes in patients with sepsis, we conducted a prospective, randomized controlled multicenter trial at 13 critical care centers in tertiary care hospitals. Methods We enrolled 60 DIC patients with sepsis and antithrombin levels of 50 to 80% in this study. The participating patients were randomly assigned to a...

  12. Reference chart derived from post-stent-implantation intravascular ultrasound predictors of 6-month expected restenosis on quantitative coronary angiography

    OpenAIRE

    Kay, Ian Patrick; Disco, Clemens; Feyter, Pim; Serruys, Patrick

    1999-01-01

    textabstractBACKGROUND: Intravascular ultrasound (IVUS)-guided stent implantation and the availability of a reference chart to predict the expected in-stent restenosis rate based on operator-dependent IVUS parameters may interactively facilitate optimal stent placement. The use of IVUS guidance protects against undue risks of dissection or rupture. METHODS AND RESULTS: IVUS-determined post-stent-implantation predictors of 6-month in-stent restenosis on quantitative coronary angiography (QCA) ...

  13. Direct sGC Activation Bypasses NO Scavenging Reactions of Intravascular Free Oxy-Hemoglobin and Limits Vasoconstriction

    OpenAIRE

    Raat, Nicolaas J.H.; Tabima, D. Marcela; Specht, Patricia A.C.; Tejero, Jesús; Champion, Hunter C; Kim-Shapiro, Daniel B; Baust, Jeff; Mik, Egbert G.; Hildesheim, Mariana; Stasch, Johannes-Peter; Becker, Eva-Maria; Truebel, Hubert; Gladwin, Mark T.

    2013-01-01

    Aims: Hemoglobin-based oxygen carriers (HBOC) provide a potential alternative to red blood cell (RBC) transfusion. Their clinical application has been limited by adverse effects, in large part thought to be mediated by the intravascular scavenging of the vasodilator nitric oxide (NO) by cell-free plasma oxy-hemoglobin. Free hemoglobin may also cause endothelial dysfunction and platelet activation in hemolytic diseases and after transfusion of aged stored RBCs. The new soluble guanylate cyclas...

  14. Post-marketing surveillance data of thrombomodulin alfa: sub-analysis in patients with sepsis-induced disseminated intravascular coagulation

    OpenAIRE

    Eguchi, Yutaka; Gando, Satoshi; Ishikura, Hiroyasu; Saitoh, Daizoh; Mimuro, Jun; Takahashi, Hoyu; Kitajima, Isao; Tsuji, Hajime; MATSUSHITA, TADASHI; Tsujita, Ryuichi; Nagao, Osamu; Sakata, Yoichi

    2014-01-01

    Background Thrombomodulin alfa (TM-α, recombinant thrombomodulin) significantly improved disseminated intravascular coagulation (DIC) when compared with heparin therapy in a phase III study. Post-marketing surveillance of TM-α was performed to evaluate the effects and safety in patients with sepsis-induced DIC. Methods From May 2008 to April 2010, a total of 1,787 patients with sepsis-induced DIC treated with TM-α were registered. DIC was diagnosed based on the Japanese Association for Acute ...

  15. Dose-volume histograms based on serial intravascular ultrasound: a calculation model for radioactive stents

    International Nuclear Information System (INIS)

    Background and purpose: Radioactive stents are under investigation for reduction of coronary restenosis. However, the actual dose delivered to specific parts of the coronary artery wall based on the individual vessel anatomy has not been determined so far. Dose-volume histograms (DVHs) permit an estimation of the actual dose absorbed by the target volume. We present a method to calculate DVHs based on intravascular ultrasound (IVUS) measurements to determine the dose distribution within the vessel wall. Materials and methods: Ten patients were studied by intravascular ultrasound after radioactive stenting (BX Stent, P-32, 15-mm length) to obtain tomographic cross-sections of the treated segments. We developed a computer algorithm using the actual dose distribution of the stent to calculate differential and cumulative DVHs. The minimal target dose, the mean target dose, the minimal doses delivered to 10 and 90% of the adventitia (DV10, DV90), and the percentage of volume receiving a reference dose at 0.5 mm from the stent surface cumulated over 28 days were derived from the DVH plots. Results were expressed as mean±SD. Results: The mean activity of the stents was 438±140 kBq at implantation. The mean reference dose was 111±35 Gy, whereas the calculated mean target dose within the adventitia along the stent was 68±20 Gy. On average, DV90 and DV10 were 33±9 Gy and 117±41 Gy, respectively. Expanding the target volume to include 2.5-mm-long segments at the proximal and distal ends of the stent, the calculated mean target dose decreased to 55±17 Gy, and DV 90 and DV 10 were 6.4±2.4 Gy and 107±36 Gy, respectively. Conclusions: The assessment of DVHs seems in principle to be a valuable tool for both prospective and retrospective analysis of dose-distribution of radioactive stents. It may provide the basis to adapt treatment planning in coronary brachytherapy to the common standards of radiotherapy

  16. The preparation of biodegradable intravascular stent and the studies of its properties

    International Nuclear Information System (INIS)

    Objective: To investigate the preparation of a biodegradable intravascular stent (BIS) with poly-l-lactic acid (PLLA), and to evaluate its physical and mechanical properties, as well as its biocompatibility. Methods: The BIS was first prepared by PLLA with molecular weight of 100 000 unit as the strut, and then the micro-porous structure was fabricated and the film was coated at the struts. Following the solidified shaping of BIS, the primary physical and mechanical properties of the BIS were tested, and 22 zigzag type BISs were implanted into the aorta and iliac arteries of 11 canines, then they were euthanized according to a fixed timetable for histopathological assessment. Results: Two types of BIS (spiral and zigzag) were prepared, and the strut diameter of the BIS was 0.1-0.6 mm, stent diameter of BIS was 6-15 mm, and stent length was 30-80 mm. Of this BIS, the radial strength was 1.6-2.0 kPa (1 kPa=7.5 mm Hg), the dilatable rate was 6.0-6.5, the shortening rate was smaller than 8%-10%, and the proportion of stent surface area to open surface area was 0.16-0.18 (< 0.2). But the radio-opacity of the BIS was low and invisible on fluoroscopy. Microscopically, a few fibrous tissues and scarce deposition of blood platelets were evidenced on the struts of BIS within one week after implantation; At 4 wk, most struts were covered by neointima. At 8 wk, the stent was covered completely by neointima, the arterial wall became smooth , and the lumen kept patent, without significant intimal proliferation. After 8 wk, the tendency of neointimal thickening seemed to reduce on images analysis. Conclusion: The physical and mechanical characteristics of this BIS may fulfill the desire for intravascular implantation, particularly the zigzag type BIS is more suitable to be deployed. After implanted into animal arteries, this BIS may induce mild inflammation in the early stage, and at 8 wk BIS may be covered completely by neointima, and no significant intimal proliferation is found

  17. Calculated dose distributions of beta-particle sources used for intravascular brachytherapy

    International Nuclear Information System (INIS)

    Purpose: Intravascular brachytherapy presents considerable challenges in prescribing, calculating and measuring dose in close proximity (< 5 mm) to sealed sources. This study focused on calculating dose distributions for a catheter-based system using Sr/Y-90 beta sources. The purpose of our investigation is to: 1) calculate the dose distribution from beta sources using the AAPM-Task Group 43 (TG43) dosimetry protocol, and 2) compare the calculated dose distributions with measured data in a water-equivalent medium (A150 plastic). Materials and Methods: Measurements were made with radiochromic film in A150 plastic of a single Sr/Y-90 seed for constructing tables of data to determine the dose rate at an arbitrary point in A150 plastic. The absorbed dose-rate from a single seed to A150 plastic at a depth of 1.98 mm was determined to be 45 ± 6.8 mGy/s using an extrapolation chamber. PC-based software was developed for calculating the dose distributions at any 3-D point in A150 plastic from any number of seeds using the AAPM TG43 formalism. Radiochromic films were exposed at different depths in A150 plastic, and digitized using a commercial CCD camera system. A calibration curve was generated from a Sr/Y-90 ophthalmic applicator for converting optical density to absolute dose. Results: Isodose curves, dose profiles and depth-dose curves were produced for comparing measured and calculated data from both a single seed and a linear array of nine seeds (referred to as a source train). Figures 1 and 2 illustrate the agreement between the calculated and measured data at a depth of 1.98 mm in A150 for both the radial and axial dose profiles, respectively. At distances greater than 0.8 mm to the source, the agreement was between the calculated and measured dose distributions was acceptable and within the uncertainty of the measured dose. Differences were observed between the calculated and measured dose data close to the source. Conclusion: The developed software can be used for both generating the isodose distributions through the three perpendicular planes and calculating the average, maximum, and minimum dose to the target. It is an effective tool for both prescribing and planning the radiation treatment for intravascular brachytherapy sources

  18. Intravascular disorders of microcirculation in patients with chronic obstructive pulmonary disease: the results of clinical and morphological examination

    Science.gov (United States)

    Fiodorova, Tatiana A.

    1999-05-01

    We have evaluated the results of clinical and morphological study of microcirculation and its intravascular factors in 120 patients with chronic obstructive pulmonary diseases (COPD). Conjunctival biomicroscopy with quantitative evaluation of microcirculatory changes we performed. This data were compared with the results of laboratory study of erythrocytes and thrombocytes aggregation, some plasma hemostasis indices and morphological examination of microcirculation. The results of conjunctival biomicroscopy showed the close correlation between the clinical severity of the disease, the degree of respiratory failure and the degree of microcirculatory disorders. Progress of the disease with the development of respiratory failure and cor pulmonale was characterized by the expansion of the process of erythrocytes aggregation to the whole parts of the microcirculatory bad and was associated with perivascular hemorrhages. In some patients with severe COPD laboratory data showed chronic disseminated intravascular microcoagulation (DVS-syndrome). Intravascular platelets, erythrocytes and mixed aggregates which completely cork the vessels and compressed endothelium were uncovered by electron microscopy. Platelets membrane injuring with its degranulation was seen. This discovered correlation between microcirculatory abnormalities in lungs and in conjunctiva in patients with COPD demonstrate that this abnormalities of microcirculation are prevalent. This allows to use in clinical accessible and informative method of conjunctival biomicroscopy to estimate the condition of microcirculation in this pathology.

  19. Linfoma no Hodgkin paranasal de células tipo B: Presentación de un caso Paranasal non-Hodgkin lymphoma of type-B cells: a case report

    Directory of Open Access Journals (Sweden)

    Sergio J Vento Cruz

    2010-12-01

    Full Text Available Se presenta el caso de un paciente de 45 años de edad, raza blanca, con antecedentes de salud, valorado en la consulta externa delPoliclínico Universitario "Fermín Valdés Domínguez" del municipio Viñales en Pinar del Río, en enero de 2007, que se presenta con una lesión tumoral a nivel de partes blandas de la mejilla derecha de un año de evolución, acompañado de obstrucción nasal, rinolalia, diplopia y buen estado general. Examen físico: aumento de volumen de la hemicara derecha de consistencia sólida, múltiples adenopatías cervicales derechas y estrabismo divergente del ojo derecho con reducción de la hendidura palpebral, la tomografía axial computarizada, reveló una opacidad tumoral del seno maxilar derecho que destruye paredes anterior, superior y posterior, la biopsia informó un diagnóstico de linfoma no hodgkin agresivo, difuso de células grandes tipo B y le fue indicado tratamiento quimioterápico y radioterápico. Dada la evolución clínica favorable del paciente, se reevaluó radiológicamente al año, persistiendo engrosamiento óseo del techo del seno maxilar. Se presentan las experiencias derivadas de la atención del caso y revisan la literatura médica con especial referencia al diagnóstico y tratamiento.A 45 years-old, Caucasian patient with a past health was examined at "Fermin Valdes Dominguez" outpatient clinic in Viñales, Pinar del Rio (January 2007 presenting a tumoral lesion in the soft tissues of the right cheek with a year of natural history which was present with nasal obstruction, rinolalia, diplopia and good general status; finding at physical examination an enhancement of volume in the right hemi-face of solid consistency, multiple right cervical adenopathies and divergent strabismus of the right eye with a reduction of the palpebral cleft. Axial Computerized Tomography revealed a tumoral opacity of the right maxillary sinus destroying the superior, anterior and posterior walls. The results of the biopsy showed the diagnosis of a diffuse aggressive no-Hodgkin lymphoma of type-B cells; indicating chemotherapy and radiotherapy. The patient's clinical progress was favorable having a radiological re-evaluation at a year of treatment, the osseous thickness of the roof in the maxillary sinus persisted. The authors presented the experiences derived from the case and the review of the medical literature making specific reference to the diagnosis and treatment.

  20. Detection of coronary plaques using MR coronary vessel wall imaging: validation of findings with intravascular ultrasound

    International Nuclear Information System (INIS)

    Compared with X-ray coronary angiography (CAG), magnetic resonance imaging of the coronary vessel wall (MR-CVW) may provide more information about plaque burden and coronary remodelling. We compared MR-CVW with intravascular ultrasound (IVUS), the standard of reference for coronary vessel wall imaging, with regard to plaque detection and wall thickness measurements. In this study 17 patients with chest pain, who had been referred for CAG, were included. Patients underwent IVUS and MR-CVW imaging of the right coronary artery (RCA). Subsequently, the coronary vessel wall was analysed for the presence and location of coronary plaques. Fifty-two matching RCA regions of interest were available for comparison. There was good agreement between IVUS and MR-CVW for qualitative assessment of presence of disease, with a sensitivity of 94% and specificity of 76%. Wall thickness measurements demonstrated a significant difference between mean wall thickness on IVUS and MR-CVW (0.48 vs 1.24 mm, P < 0.001), but great heterogeneity between wall thickness measurements, resulting in a low correlation between IVUS and MR-CVW. MR-CVW has high sensitivity for the detection of coronary vessel wall thickening in the RCA compared with IVUS. However, the use of MRI for accurate absolute wall thickness measurements is not supported when a longitudinal acquisition orientation is used. (orig.)