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Linfoma intravascular do pulmão: A propósito de um caso clínico com boa resposta à terapêutica / Intravascular pulmonary lymphoma with good response to treatment. A case report  

Scientific Electronic Library Online (English)

Full Text Available SciELO Portugal | Language: Portuguese Abstract in portuguese O linfoma intravascular é uma forma muito rara de linfoma não Hodgkin de células grandes B. Caracteriza-se pela proliferação celular tumoral de linfócitos limitada aos pequenos vasos, particularmente nos capilares. Apresentamos o caso de uma doente de 54 anos, não fumadora, que foi admitida no nosso [...] hospital para investigação de um quadro com quatro meses de evolução de febre, sudorese nocturna, emagrecimento não quantificado e dispneia progressiva. Ao exame objectivo apresentava-se febril, taquicárdica e polipneica. Analiticamente, destacava-se anemia, leucocitose e LDH elevada. Gasometria arterial - FiO2 1 l/m: PaO2-63,6 mm Hg. A telerradiografia de tórax revelava infiltado intersticial difuso. Foram excluídas todas as causas de febre de origem indeterminada. O diagnóstico foi realizado por biópsia pulmonar cirúrgica e foi prescrita terapêutica citostática combinada e rituximab com boa resposta clínica. Relatamos o caso pela dificuldade diagnóstica e pela boa resposta à terapêutica. Abstract in english Intravascular lymphoma is a very rare form of large B cell non-Hodgkin’s lymphoma, characterised by the presence of lymphoma cells in the lumina of small vessels only, particulary in the capillaries. We report a 54 year-old female non-smoker, admitted to hospital for further examination of a four mo [...] nth long clinical condition involving high fever, night sweats, unqualified weight loss and progressive dyspnea. Patient’s temperature was 38.5 ºC, pulse 100/min and respiratory 22 cycles/min. Patient’s haemoglobin was 9.4g/dL, she had leukocytosis, elevated LDH and arterial blood gas analysis with moderate hypoxaemia (FiO2 1l/m: PaO2-63.6 mm Hg). Chest X-ray revealed diffuse interstitial changes. All the possible causes of unknown origin fever were excluded. Diagnosis was made through lung biopsy and treatment with combined chemotherapy and rituximab was prescribed leading to a 48 hours clinical remission. We present this case to show how difficult this diagnosis can be and how a good response to therapy is possible.

M, Felizardo; A C, Mendes; A, Fernandes; P, Campos; V, Magalhães; I, Correia; A, Pignatelli; C, Ferreira; R, Sotto-Mayor; A Bugalho de, Almeida.

2008-12-01

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Linfoma intravascular do pulmão: A propósito de um caso clínico com boa resposta à terapêutica / Intravascular pulmonary lymphoma with good response to treatment. A case report  

Scientific Electronic Library Online (English)

Full Text Available SciELO Portugal | Language: Portuguese Abstract in portuguese O linfoma intravascular é uma forma muito rara de linfoma não Hodgkin de células grandes B. Caracteriza-se pela proliferação celular tumoral de linfócitos limitada aos pequenos vasos, particularmente nos capilares. Apresentamos o caso de uma doente de 54 anos, não fumadora, que foi admitida no nosso [...] hospital para investigação de um quadro com quatro meses de evolução de febre, sudorese nocturna, emagrecimento não quantificado e dispneia progressiva. Ao exame objectivo apresentava-se febril, taquicárdica e polipneica. Analiticamente, destacava-se anemia, leucocitose e LDH elevada. Gasometria arterial - FiO2 1 l/m: PaO2-63,6 mm Hg. A telerradiografia de tórax revelava infiltado intersticial difuso. Foram excluídas todas as causas de febre de origem indeterminada. O diagnóstico foi realizado por biópsia pulmonar cirúrgica e foi prescrita terapêutica citostática combinada e rituximab com boa resposta clínica. Relatamos o caso pela dificuldade diagnóstica e pela boa resposta à terapêutica. Abstract in english Intravascular lymphoma is a very rare form of large B cell non-Hodgkin’s lymphoma, characterised by the presence of lymphoma cells in the lumina of small vessels only, particulary in the capillaries. We report a 54 year-old female non-smoker, admitted to hospital for further examination of a four mo [...] nth long clinical condition involving high fever, night sweats, unqualified weight loss and progressive dyspnea. Patient’s temperature was 38.5 ºC, pulse 100/min and respiratory 22 cycles/min. Patient’s haemoglobin was 9.4g/dL, she had leukocytosis, elevated LDH and arterial blood gas analysis with moderate hypoxaemia (FiO2 1l/m: PaO2-63.6 mm Hg). Chest X-ray revealed diffuse interstitial changes. All the possible causes of unknown origin fever were excluded. Diagnosis was made through lung biopsy and treatment with combined chemotherapy and rituximab was prescribed leading to a 48 hours clinical remission. We present this case to show how difficult this diagnosis can be and how a good response to therapy is possible.

M, Felizardo; A C, Mendes; A, Fernandes; P, Campos; V, Magalhães; I, Correia; A, Pignatelli; C, Ferreira; R, Sotto-Mayor; A Bugalho de, Almeida.

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High grade primary adrenal intravascular large B-cell lymphoma manifesting as Addison disease Linfoma intravascular de alto grado de células B grandes y origen suprarrenal que se manifiesta en forma de enfermedad de Addison  

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Full Text Available We report a rare case of a 68 aged male who presented with adrenal failure and was diagnosed of high grade large B-cell lymphoma primarily arising in the adrenal glands. The patient was administrated with additional chemotherapy but he passed away 7 months later due to infection in the lungs. Intravascular lymphoma should be suspected in patients with bilateral adrenal masses who present with rapidly progressive adrenal insufficiency.Publicamos el caso poco frecuente de un varón de 68 años de edad que debutó con insuficiencia adrenal y fue diagnosticado de linfoma de alto grado de células B grandes ubicado principalmente en las glándulas suprarrenales. Al paciente le administraron quimioterapia adicional, pero falleció 7 meses después de infección pulmonar. El linfoma intravascular debe sospecharse en los pacientes con masas suprarrenales bilaterales que presenten insuficiencia adrenal rápidamente progresiva.

J. Venizelos

2007-08-01

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High grade primary adrenal intravascular large B-cell lymphoma manifesting as Addison disease / Linfoma intravascular de alto grado de células B grandes y origen suprarrenal que se manifiesta en forma de enfermedad de Addison  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: English Abstract in spanish Publicamos el caso poco frecuente de un varón de 68 años de edad que debutó con insuficiencia adrenal y fue diagnosticado de linfoma de alto grado de células B grandes ubicado principalmente en las glándulas suprarrenales. Al paciente le administraron quimioterapia adicional, pero falleció 7 meses d [...] espués de infección pulmonar. El linfoma intravascular debe sospecharse en los pacientes con masas suprarrenales bilaterales que presenten insuficiencia adrenal rápidamente progresiva. Abstract in english We report a rare case of a 68 aged male who presented with adrenal failure and was diagnosed of high grade large B-cell lymphoma primarily arising in the adrenal glands. The patient was administrated with additional chemotherapy but he passed away 7 months later due to infection in the lungs. Intrav [...] ascular lymphoma should be suspected in patients with bilateral adrenal masses who present with rapidly progressive adrenal insufficiency.

J., Venizelos; D., Tamiolakis; M., Lambropoulou; G., Alexiadis; G., Petrakis; N., Papadopoulos.

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Linfoma no Hodgkin secundario a inmunosupresión por transplate renal tratado con quimioterapia  

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Full Text Available SciELO Venezuela | Language: Spanish Abstract in spanish OBJETIVO: Los síndromes linfoproliferativos posterior a trasplante renal incluyen un grupo de enfermedades linfoides que por definición se presentan después del mismo en un órgano sólido o en la médula ósea y están en relación con la terapia inmunosupresora administrada. La probabilidad de desarroll [...] ar una neoplasia maligna en un receptor de trasplante renal seguido a lo largo de 17 años, es de un 14 % para cánceres no cutáneos, de un 47 % en los carcinomas de piel y un 55 % para cualquier tipo de cáncer. MÉTODO: En este trabajo se describe un caso poco común de un paciente de 40 años con insuficiencia renal crónica secundario a hipertensión arterial en hemodiálisis, quien se le realizó trasplante renal de cadáver en el 2007, presentando alteración de función renal con masa palpable en fosa ilíaca derecha, en tratamiento con inmunosupresores. RESULTADOS: El examen histopatológico de la biopsia reportó: desorden linfoproliferativo posterior a trasplante con inmunohistoquímica positivo para CD20, CD79 en células linfoides B y CD45 en células linfoides T. Estudios de extensión metástasis en mediastino concluyéndose como: linfoma no Hodgkin inmunofenotipo B CD20+ estadio IV extra nodal renal con metástasis en mediastino superior mayo/2009 IPI score alto riesgo secundario a trasplante renal. Recibió tratamiento con R-CHOP obteniéndose respuesta oncológica completa, demostrado por CT-PET, actualmente libre de enfermedad, en controles nefrológicos. CONCLUSIÓN: Se debe vigilar cualquier alteración clínica, ya que un rechazo de trasplante se puede confundir con una patología oncológica. Abstract in english OBJECTIVE: The posterior transplant lymph syndrome proliferative disorders include a group of renal lymphoid diseases by definition are present after a solid organ transplant or in bone marrow and are related to immunosuppressive therapy administered. The likelihood of developing a malignancy renal [...] transplant recipient followed over the 17 years is 14 % for the non-skin cancers, 47 % in the carcinomas of the skin and 55 % for any type of cancer. METHOD: In this work we describes a rare case of a 40 year old patient with chronic renal failure secondary to arterial hypertension in hemodialysis, who underwent cadaveric renal transplant in 2007, the patient presented impaired renal function with palpable mass in right iliac fosse, in treatment with immune suppressants. RESULTS: The histopathology examination of the biopsy reported, posterior transplant with lymphoproliferative disorder with immunohistochemistry positive for CD20, CD79 on B lymphoid cells and CD45 on T lymphoid cells, the extension studies concluding that the mediastinal metastases were: Non-Hodgkin’s lymphoma immunophenotyping B extranodal CD20 + stage IV renal with metastases in the superior mediastinum IPI score May/2009 classified how secondary to high risk renal transplantation. The patient was treated with R-CHOP we obtained a oncology complete response, as demonstrated by CT-PET, and currently free of disease, in nephrology controls. CONCLUSION: It should monitor any clinical manifestation in the treatment of this kind of patients and served as a rejection of transplant can be confused with metastatic brain tumor.

Ámbar, Guzmán; Hugo, Ruíz; Oneida, Parra; Carmen, Umbría; Angelo, Garofalo; Luisa, González; Karen, Kubicek.

2011-03-01

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Linfoma no Hodgkin secundario a inmunosupresión por transplate renal tratado con quimioterapia  

Scientific Electronic Library Online (English)

Full Text Available SciELO Venezuela | Language: Spanish Abstract in spanish OBJETIVO: Los síndromes linfoproliferativos posterior a trasplante renal incluyen un grupo de enfermedades linfoides que por definición se presentan después del mismo en un órgano sólido o en la médula ósea y están en relación con la terapia inmunosupresora administrada. La probabilidad de desarroll [...] ar una neoplasia maligna en un receptor de trasplante renal seguido a lo largo de 17 años, es de un 14 % para cánceres no cutáneos, de un 47 % en los carcinomas de piel y un 55 % para cualquier tipo de cáncer. MÉTODO: En este trabajo se describe un caso poco común de un paciente de 40 años con insuficiencia renal crónica secundario a hipertensión arterial en hemodiálisis, quien se le realizó trasplante renal de cadáver en el 2007, presentando alteración de función renal con masa palpable en fosa ilíaca derecha, en tratamiento con inmunosupresores. RESULTADOS: El examen histopatológico de la biopsia reportó: desorden linfoproliferativo posterior a trasplante con inmunohistoquímica positivo para CD20, CD79 en células linfoides B y CD45 en células linfoides T. Estudios de extensión metástasis en mediastino concluyéndose como: linfoma no Hodgkin inmunofenotipo B CD20+ estadio IV extra nodal renal con metástasis en mediastino superior mayo/2009 IPI score alto riesgo secundario a trasplante renal. Recibió tratamiento con R-CHOP obteniéndose respuesta oncológica completa, demostrado por CT-PET, actualmente libre de enfermedad, en controles nefrológicos. CONCLUSIÓN: Se debe vigilar cualquier alteración clínica, ya que un rechazo de trasplante se puede confundir con una patología oncológica. Abstract in english OBJECTIVE: The posterior transplant lymph syndrome proliferative disorders include a group of renal lymphoid diseases by definition are present after a solid organ transplant or in bone marrow and are related to immunosuppressive therapy administered. The likelihood of developing a malignancy renal [...] transplant recipient followed over the 17 years is 14 % for the non-skin cancers, 47 % in the carcinomas of the skin and 55 % for any type of cancer. METHOD: In this work we describes a rare case of a 40 year old patient with chronic renal failure secondary to arterial hypertension in hemodialysis, who underwent cadaveric renal transplant in 2007, the patient presented impaired renal function with palpable mass in right iliac fosse, in treatment with immune suppressants. RESULTS: The histopathology examination of the biopsy reported, posterior transplant with lymphoproliferative disorder with immunohistochemistry positive for CD20, CD79 on B lymphoid cells and CD45 on T lymphoid cells, the extension studies concluding that the mediastinal metastases were: Non-Hodgkin’s lymphoma immunophenotyping B extranodal CD20 + stage IV renal with metastases in the superior mediastinum IPI score May/2009 classified how secondary to high risk renal transplantation. The patient was treated with R-CHOP we obtained a oncology complete response, as demonstrated by CT-PET, and currently free of disease, in nephrology controls. CONCLUSION: It should monitor any clinical manifestation in the treatment of this kind of patients and served as a rejection of transplant can be confused with metastatic brain tumor.

Ámbar, Guzmán; Hugo, Ruíz; Oneida, Parra; Carmen, Umbría; Angelo, Garofalo; Luisa, González; Karen, Kubicek.

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Linfoma Gástrico Primario  

Scientific Electronic Library Online (English)

Full Text Available SciELO Peru | Language: Spanish Abstract in spanish Introducción: El Linfoma Gástrico Primario es una entidad infrecuente dentro de las neoplasias que afectan el estómago. La histología del Linfoma Gástrico Primario es variada y adquiere connotación especial el Linfoma a células B de la zona marginal extranodal, por su potencial remisión con la antib [...] ioticoterapia. Objetivos: Apreciar las características clínicas de los pacientes con Linfoma Gástrico Primario, los hallazgos endoscópicos más relevantes, identificar los factores que influencian la supervivencia y evaluar los efectos de la terapia. Material y métodos: El presente estudio es de tipo observacional, analítico y de corte transversal, se realizó en 169 pacientes con diagnóstico histológico de Linfoma Gástrico que fueron atendidos en el Instituto Especializado de Enfermedades Neoplásicas, Lima-Perú, desde Enero de 1995 a Diciembre del 2000. Para el estadiaje se utilizó el sistema Ann Arbor modificado por Musshoff y la histología de acuerdo a la clasificación REAL-WHO. El análisis estadístico incluyó el t de student y el chi cuadrado. La supervivencia fue consignada con las curvas de Kaplan Meier y los factores pronóstico con el test de regresión de Cox. Resultados: La muestra es representativa de pacientes de la Costa Peruana. La edad promedio es 55 años, con discreta predominancia del sexo femenino (54.4%). Los signos y síntomas son inespecíficos. El estadio clínico I-II corresponde al 75% de los pacientes. El patrón endoscópico de lesiones ulceradas múltiples es característico del Linfoma Gástrico. El 71% de los pacientes con Linfoma a células B de la zona marginal extranodal tuvieron remisión completa de la enfermedad con antibióticoterapia (5/7). El tipo histológico del Linfoma Gástrico en los 169 pacientes fue el siguiente: Linfoma a células B grande difuso 137 pacientes, Linfoma a células B de la zona marginal extra nodal 16 pacientes, Linfoma a células T periférico 6 pacientes, Linfoma a células grandes T anaplásico 3 pacientes, Linfoma no determinado 3 pacientes, Linfoma a células del manto 2 pacientes, Linfoma a células T del adulto 1 paciente y Linfoma folicular 1 paciente. La sobrevida global a 36 meses fue de 61.34%, la supervivencia de acuerdo al tipo histológico fue del 92.31% para Los Linfomas a células B de la zona marginal extranodal, del 62.21% para los Linfomas a células B grande difuso y del 29.63% para los Linfomas a células T. La sobrevida a 36 meses en pacientes con estadio clínico I-II que fueron tratados con quimioterapia fue del 82.16%, con cirugía fue del 71.89% y con cirugía más quimioterapia fue del 70.39%, mostrando los 3 grupos resultados semejantes (p: 0.6530). Los grupos catalogados de acuerdo al índice internacional, mostraron una clara diferencia entre ellos (p: 0.0000). El análisis univariado reveló que el Zubrod (p: 0.0000), el DHL (p: 0.0073), la remisión de la enfermedad (p: 0.0000), el estadio (p: 0.0000), el tratamiento (p: 0.0000), y la localización (p: 0.0000), tuvieron significancia estadística. El análisis multivariado mostró que en el modelo de regresión de Cox, la remisión (OR: 13.342, p: 0.0000), y la localización (OR: 2.375, p: 0.041), se encuentran dentro de la ecuación de dicha función. Conclusiones: Las lesiones ulceradas múltiples son características del Linfoma Gástrico. Se demuestra remisión de enfermedad en el Linfoma a células B de la zona marginal extranodal con antibioticoterapia (5/7). La quimioterapia en pacientes con EC I-II, alcanza resultados de supervivencia semejantes a la cirugía y a la combinación de ambas. Se confirma la validez del índice internacional y se demuestra en el análisis multivariado que la remisión y la localización de la enfermedad tienen significancia estadística. Abstract in english Introduction: Primary Gastric Lymphoma is an uncommon malignancy among gastric malignancies. Histology of the Primary Gastric Lymphoma is varied and the extranodal marginal zone B-cells lympho

Fernando, Barreda B; Regina, Gómez P; Dolly, Quispe L; Juvenal, Sánchez L; Juan, Combe G; Luis, Casanova M; Juan, Celis Z.

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Estudo prospectivo e randomizado de pacientes tratados com e sem stents revestidos com carbeto de silício amorfo para a prevenção da reestenose coronariana. Avaliação ultra-sonográfica / Randomized intravascular ultrasound comparison between endoprostheses with and without amorphous silicon-carbide  

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Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese OBJETIVO: A reestenose intra-stent é a maior limitação das intervenções coronárias percutâneas. O carbeto de silício amorfo (SiC-a), substância antitrombótica e antiinflamatória capaz de reduzir a deposição de fibrina, plaquetas e leucócitos sobre o stent, apresenta potencial de prevenir a hiperplas [...] ia neo-intimal e a reestenose. MÉTODOS: Estudo prospectivo, randomizado e tipo rótulo aberto comparando pacientes com doença coronariana tratados com e sem stents revestidos com o SiC-a, utilizando a angiografia quantitativa e o ultra-som intracoronário. Foram incluídos 100 pacientes (50 em cada grupo) a fim de mensurar o volume de hiperplasia neo-intimal intra-stent/extremidades. Como os stents comparados apresentavam extensões diferentes, o volume de hiperplasia foi analisado em valores absolutos (por paciente) e relativos (por milímetro de extensão do stent). Avaliaram-se ainda os eventos cardíacos maiores e os resultados da angiografia quantitativa. RESULTADOS: Os grupos apresentaram características de base semelhantes. Todos os pacientes foram tratados com sucesso. No 6° mês de evolução foram reestudados 94% dos casos dos dois grupos, obtendo-se ultra-som em 92%. O volume de hiperplasia neo-intimal absoluto foi significativamente maior nos tratados com os stents revestidos (51.2 DP 18.8 mm³ vs 41.9 DP 16.4 mm³; p=0.014), porém o relativo foi semelhante (2.9 DP 1.0 mm³/mm stent vs 2.5 DP 0.9 mm³/mm stent; p=0.108). A obstrução volumétrica da luz também foi similar (36.4 DP 11.1% vs 37.9 DP 10.9%; p=0.505). O diâmetro mínimo da luz (1.9 DP 0.7 mm vs 1.8 DO 0.6 mm; p=0.552), a reestenose (19.1% vs 17%; p>0.999) e a revascularização do vaso-alvo (16% vs 14%; p>0.999) não diferiram. CONCLUSÃO: Os stents revestidos apresentaram resultados clínicos, angiográficos e ultra-sonográficos similares aos controles. Abstract in english OBJECTIVE: In-stent restenosis remains a major limitation following coronary stent implantation. Amorphous silicon-carbide (a-SiC) coating has been shown to improve stent biocompatibility, therefore, reducing local inflammation and thrombus generation. Due to the latter, a-SiC coating might have an [...] impact on the prevention of neointimal hyperplasia (NIH) and restenosis. METHODS: This prospective, randomized, open-label trial compared a-SiC-coated (group A) versus uncoated (group B) stent implantation in de novo lesions. We included 100 patients (50 patients in each group) and the primary end-point was in-stent volume of NIH measured by intravascular ultrasound. RESULTS: All patients underwent successful stent deployment. Although absolute NIH volume was greater in A (51.2 mm³ SD 18.8 mm³ versus 41.9 mm³ SD 16.4 mm³; P = 0.014), relative (divided per mm of stent length) NIH volume was similar (2.9 mm³/mm stent SD 1.0 mm³/mm stent versus 2.5 mm³/mm stent SD 0.9 mm³/mm stent; P = 0.108). Late loss, restenosis, and major adverse cardiac events (MACE) were similar. CONCLUSION: A-SiC-coated stents did not reduce either NIH or MACE at long-term follow-up.

Luiz Fernando Leite, Tanajura; J. Eduardo M. R., Sousa; Amanda G. M. R., Sousa; Alexandre, Abizaid; João Eduardo T., Paula; Mariano, Albertal; Fausto, Feres; Luiz Alberto P., Mattos; Rodolfo, Staico; Ibraim M.F., Pinto.

2004-12-01

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LINFOMA PRIMARIO DE LA MAMA  

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Full Text Available SciELO Chile | Language: Spanish Abstract in spanish Se presenta un caso clínico de Linfoma primario de la mama, patología de muy baja ocurrencia (0,1% de los cánceres de mama), en una mujer de 71 años, diagnosticado y tratado en la Unidad de Patología Mamaria del Servicio de Obstetricia y Ginecología del Hospital Clínico San Borja Arriarán en enero d [...] el 2002 Abstract in english A case report of Primary Lymphoma of the Breast, a very unusual breast pathology, that occur in approximately 0.1% of all breast cancer, is presented because of an outstanding clinical case, in a 71 years old woman, diagnosed and managed at the Breast Pathology Unit of the Gynecology Service of "San [...] Borja Arriarán Hospital" in January of 2002

Jaime, Letzkus B.; Octavio, Peralta M.; Galina, Ivanova; Jorge, Gamboa G.; Alejandro, Belmar S.; Cesar, del Castillo S.; Mónica, Campos M.; Paulina, Peñaloza; Valeria, Cornejo C.; Eugenio, Vinés V..

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Linfoma renal primario / Primary renal lymphoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish OBJETIVO: Presentar un caso de linfoma renal primario. MATERIAL Y MÉTODOS: Estudiamos el caso clínico de un paciente en el que se descubrió una masa renal, con el diagnóstico anatomopatológico de linfoma renal primario. RESULTADOS: Se trata de un paciente de 78 años de edad que acudió a nuestra cons [...] ulta por dolor en fosa renal derecha. Al realizar varias pruebas complementarias se llegó al diagnóstico de masa renal derecha, cuyo estudio anatomopatológico tras punción-biopsia reveló un linfoma difuso de células B, siendo tratado con ciclos de quimioterapia sistémica según la pauta CHOP. CONCLUSIONES: El linfoma renal primario es una entidad rara y cuestionada por muchos autores. En la práctica clínica se presenta de modo similar al resto de tumores renales, por lo que su diagnóstico debe ser histológico. El tratamiento de elección es la quimioterapia sistémica con la combinación CHOP. Abstract in english OBJECTIVE: To describe a case of primary renal lymphoma. MATERIAL AND METHODS: We presents a patient with a right renal mass which histological analysis revealed a non-Hodgkin Lymphoma. RESULTS: A 78-year-old male patient with right flank pain mass was referred to our Service. He was diagnosed of re [...] nal mass by imaging studies. Inmunohistochemical investigations revealed a B-cell-type lymphoma. He received combination chemotherapy with CHOP. CONCLUSIONS: Primary renal lymphoma is a rare disease whose existence has been questioned, because the kidney does not normally contain lymphoid tissue. Its clinical presentation is like any other renal tumor and its definitive diagnosis is by histology. Elective treatment is chemotherapy (CHOP).

J.R., Torrecilla García-Ripoll; M., Pascual Samaniego; S., Martín Blanco; J., Rivera Ferro; J.I., Peral Martínez; E., Fernández del Busto.

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LINFOMA PULMONAR PRIMARI0  

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Full Text Available Se presentó el caso de un paciente con enfermedad de Hodgkin aquejado de linfoma pulmonar primario; se revisaron los diversos métodos diagnósticos empleados, así como el diferencial. El diagnóstico radiológico fue el más utilizado. Se discutieron los criterios anatomopatológicos de extensión y cronológicos necesarios para la confirmación. Se destacó que la quimioterapia es útil en la evolución de estos enfermos.

Rafael Pila P\\u00E9rez

2004-01-01

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Estudo prospectivo e randomizado de pacientes tratados com e sem stents revestidos com carbeto de silício amorfo para a prevenção da reestenose coronariana. Avaliação ultra-sonográfica Randomized intravascular ultrasound comparison between endoprostheses with and without amorphous silicon-carbide  

Digital Repository Infrastructure Vision for European Research (DRIVER)

OBJETIVO: A reestenose intra-stent é a maior limitação das intervenções coronárias percutâneas. O carbeto de silício amorfo (SiC-a), substância antitrombótica e antiinflamatória capaz de reduzir a deposição de fibrina, plaquetas e leucócitos sobre o stent, apresenta potencial de prevenir a hiperplasia neo-intimal e a reestenose. MÉTODOS: Estudo prospectivo, randomizado e tipo rótulo aberto comparando pacientes com doença coronariana tratados com e sem stents revestidos com o ...

Luiz Fernando Leite Tanajura; Sousa, J. Eduardo M. R.; Sousa, Amanda G. M. R.; Alexandre Abizaid; Paula, Joa?o Eduardo T.; Mariano Albertal; Fausto Feres; Mattos, Luiz Alberto P.; Rodolfo Staico; Pinto, Ibraim M. F.

2004-01-01

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Linfomas orbitarios: Presentación de nueve casos Orbital lymphomas: Presentation of nine cases  

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Full Text Available Objetivo: Describir nueve casos de linfomas orbitarios. Métodos: Revisión de historias clínicas de nueve pacientes diagnosticados de linfoma orbitario y consulta de la bibliografía relacionada con esta patología. Resultados: Se presenta una serie compuesta por cinco mujeres y cuatro varones con linfoma en la región orbitaria. En nuestros casos, la mayoría de los pacientes presentaron linfoma extraorbitario concurrente en el momento en el que el proceso orbitario fue detectado por primera vez (siete de los nueve pacientes. Tres de los pacientes presentaron linfoma MALT, dos linfomas foliculares, dos linfomas no Hodgkin de células B grandes, un linfoma de células B de bajo grado y un linfoma de células del manto. Ocho pacientes se mantienen vivos y uno ha fallecido a consecuencia de su linfoma en el momento de escribir este artículo. Conclusiones: Se ha observado un incremento de la incidencia de los linfomas no Hodgkin orbitarios durante las últimas tres décadas. El tipo más común en la región orbitaria es el linfoma MALT. La forma de presentación clínica que encontramos en nuestra serie es similar a la que se presenta en otros estudios. Dado que los linfomas son los tumores malignos más frecuentes en la órbita, habitualmente tienen también localización extraorbitaria, y pueden ser tratados con éxito en muchos casos, es importante que el oftalmólogo tenga presente esta patología.Purpose: To report nine cases of orbital lymphomas. Methods: We reviewed the clinical records of nine patients diagnosed with orbital lymphoma and performed a literature search related to this condition. Results: We present a series of five women and four males with orbital lymphoma involving the orbital region. In our cases, most patients presented concurrent extraorbital lymphoma when the orbital disease was first noticed (seven out of nine patients. We found three MALT lymphomas, two follicular lymphomas, two non-Hodgkin large B cell lymphomas, one low grade B cell lymphoma, and one mantle cell lymphoma. Eight patients were alive and one had died as a consequence of his lymphoma at the time this report was written. Conclusions: An increase in the incidence of non-Hodgkin orbital lymphomas has been observed over the last three decades. The most common type in the orbital region is the MALT lymphoma. The clinical features observed in our series are similar to those reported in the literature. Since lymphomas are the most frequent malignant tumours in the orbit, usually with extraorbital involvement, and can be successfully treated in many cases, it is important for the ophthalmologist to be aware of this condition.

C. Rey-Porca

2008-02-01

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Linfomas orbitarios: Presentación de nueve casos / Orbital lymphomas: Presentation of nine cases  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish Objetivo: Describir nueve casos de linfomas orbitarios. Métodos: Revisión de historias clínicas de nueve pacientes diagnosticados de linfoma orbitario y consulta de la bibliografía relacionada con esta patología. Resultados: Se presenta una serie compuesta por cinco mujeres y cuatro varones con linf [...] oma en la región orbitaria. En nuestros casos, la mayoría de los pacientes presentaron linfoma extraorbitario concurrente en el momento en el que el proceso orbitario fue detectado por primera vez (siete de los nueve pacientes). Tres de los pacientes presentaron linfoma MALT, dos linfomas foliculares, dos linfomas no Hodgkin de células B grandes, un linfoma de células B de bajo grado y un linfoma de células del manto. Ocho pacientes se mantienen vivos y uno ha fallecido a consecuencia de su linfoma en el momento de escribir este artículo. Conclusiones: Se ha observado un incremento de la incidencia de los linfomas no Hodgkin orbitarios durante las últimas tres décadas. El tipo más común en la región orbitaria es el linfoma MALT. La forma de presentación clínica que encontramos en nuestra serie es similar a la que se presenta en otros estudios. Dado que los linfomas son los tumores malignos más frecuentes en la órbita, habitualmente tienen también localización extraorbitaria, y pueden ser tratados con éxito en muchos casos, es importante que el oftalmólogo tenga presente esta patología. Abstract in english Purpose: To report nine cases of orbital lymphomas. Methods: We reviewed the clinical records of nine patients diagnosed with orbital lymphoma and performed a literature search related to this condition. Results: We present a series of five women and four males with orbital lymphoma involving the or [...] bital region. In our cases, most patients presented concurrent extraorbital lymphoma when the orbital disease was first noticed (seven out of nine patients). We found three MALT lymphomas, two follicular lymphomas, two non-Hodgkin large B cell lymphomas, one low grade B cell lymphoma, and one mantle cell lymphoma. Eight patients were alive and one had died as a consequence of his lymphoma at the time this report was written. Conclusions: An increase in the incidence of non-Hodgkin orbital lymphomas has been observed over the last three decades. The most common type in the orbital region is the MALT lymphoma. The clinical features observed in our series are similar to those reported in the literature. Since lymphomas are the most frequent malignant tumours in the orbit, usually with extraorbital involvement, and can be successfully treated in many cases, it is important for the ophthalmologist to be aware of this condition.

C., Rey-Porca; M., Pérez-Encinas; F., González.

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Linfoma de Burkitt Burkitt lymphoma  

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Full Text Available El linfoma de Burkitt es un tipo de linfoma no Hodgkin, no frecuente en Cuba, pues es endémico de África Central. Diagnosticar uno en nuestro país siempre es significativo, por lo que conocerlo es importante.The Burkitt lymphoma is a type of non-Hodgkin lymphoma infrequent in Cuba since it is endemic of Central Africa. The diagnosis of one in our country always is significant, thus it is important to know it.

Fernando Sierra Arego

2012-03-01

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Disseminated intravascular coagulation (DIC)  

Science.gov (United States)

... Jr, Silberstein LE, et al., eds. Hematology: Basic Principles and Practice . 6th ed. Philadelphia, Pa: Elsevier Saunders; 2012:chap 141. Thachil J, Toh CH. Current concepts in the management of disseminated intravascular coagulation. Thromb Res . 2012;129 ...

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Intravascular malignant lymphomatosis  

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Intravascular malignant lymphomatosis is a rare and probably often overlooked disease characterised by massive intravascular proliferation of lymphoid cells, usually with a poor prognosis. CT and MRI appearances are nonspecific; the most suggestive finding being both asymmetrical, bilateral, contrast enhancing high-signal areas on T2 weighting and infarct-like lesions of the cortex and basal ganglia. We report two patients with previously unreported dural and spinal cord involvement. (orig.)

Martin-Duverneuil, N.; Lafitte, F.; Chiras, J. [Service de Neuroradiologie Charcot, Batiment Babinski, Hopital de la Salpetriere, 75013 Paris (France); Mokhtari, K. [Service de Neuropathologie, Hopital de la Salpetriere, 75013 Paris (France); Behin, A.; Hoang-Xuan, K. [Departement de Neurologie, Hopital de la Salpetriere, 75013 Paris (France)

2002-09-01

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Intravascular malignant lymphomatosis  

International Nuclear Information System (INIS)

Intravascular malignant lymphomatosis is a rare and probably often overlooked disease characterised by massive intravascular proliferation of lymphoid cells, usually with a poor prognosis. CT and MRI appearances are nonspecific; the most suggestive finding being both asymmetrical, bilateral, contrast enhancing high-signal areas on T2 weighting and infarct-like lesions of the cortex and basal ganglia. We report two patients with previously unreported dural and spinal cord involvement. (orig.)

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Linfoma de Burkitt / Burkitt lymphoma  

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Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish El linfoma de Burkitt es un tipo de linfoma no Hodgkin, no frecuente en Cuba, pues es endémico de África Central. Diagnosticar uno en nuestro país siempre es significativo, por lo que conocerlo es importante. [...] Abstract in english The Burkitt lymphoma is a type of non-Hodgkin lymphoma infrequent in Cuba since it is endemic of Central Africa. The diagnosis of one in our country always is significant, thus it is important to know it. [...

Fernando, Sierra Arego; Carlos Michel, López Rodríguez.

20

Disseminated intravascular coagulation.  

Science.gov (United States)

Healthy pregnancy is accompanied by changes in the haemostatic system which convert it into a hypercoagulable state vulnerable to a spectrum of disorders ranging from venous thromboembolism to disseminated intravascular coagulation (DIC). This latter is always a secondary phenomenon triggered by specific disorders such as abruptio placentae and amniotic fluid embolism due to release of thromboplastin intravascularly or endothelial damage resulting from pre-eclampsia and sepsis. In modern obstetric practice the most common cause is haemorrhagic shock with delay in resuscitation leading to endothelial damage. The initial management of massive obstetric haemorrhage is the same whether associated with coagulopathy initially or not. Low-grade DIC, associated with pre-eclampsia, is monitored haematologically by serial platelet counts and serum fibrin degradation products (FDPs). Supportive measures and removal of the triggering mechanism are the key to successful management. Outcome depends primarily on our ability to deal with the trigger and not on direct attempts to correct the coagulation deficit. PMID:11478819

Letsky, E A

2001-08-01

 
 
 
 
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Coagulación intravascular diseminada / Disseminated intravascular coagulation  

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Full Text Available SciELO Colombia | Language: Spanish Abstract in spanish La coagulación intravascular diseminada (CID) es una entidad clínica frecuente que se presenta como fenómeno secundario a diversas enfermedades entre las cuales se destacan las infecciones graves, las neoplasias y las catástrofes obstétricas. Se caracteriza por una activación difusa y simultánea de [...] los sistemas endógenos de la coagulación y la fibrinólisis. El depósito de pequeños trombos en la circulación conduce finalmente a disfunción orgánica múltiple y en algunos casos a la muerte. Las manifestaciones clínicas pueden incluir fenómenos trombóticos y hemorrágicos. Se ha propuesto un puntaje de fácil aplicación para simplificar el diagnóstico de la entidad. El tratamiento incluye el control específico de la causa subyacente que favorece la aparición de la CID, el soporte con hemoderivados en pacientes con manifestaciones de sangrado y la anticoagulación terapéutica en pacientes con trombosis mayores. El desarrollo de CID es un factor pronóstico adverso que aumenta significativamente la tasa de mortalidad. En este artículo de revisión se incluyen los siguientes aspectos de la CID: historia, epidemiología, clasificación, entidades asociadas, fisiopatología, clínica, diagnóstico, tratamiento y pronóstico. Abstract in english Disseminated intravascular coagulation (DIC) is a frequent clinical entity that presents as a secondary phenomenon associated with some diseases, including, among others, severe infections, neoplastic disorders and obstetric catastrophes. It is characterized by a diffuse and simultaneous activation [...] of the clotting and fibrinolytic systems. The deposit of small thrombi in the circulation eventually leads to dysfunction of multiple organs, and in some cases to death. Clinical findings include thrombotic as well as hemorrhagic manifestations. A simple scoring system has been proposed to aid in the diagnosis of this entity. Treatment includes the specific management of the underlying cause that triggered the DIC, support with blood products in patients with bleeding manifestations and therapeutic anticoagulation in patients with thrombotic events. The development of DIC is an adverse prognostic factor that significantly increases mortality. In this review article the following aspects of CID are included: history, epidemiology, classification, associated diseases, physiopathology, clinical presentation, diagnosis, treatment and prognosis.

Marcos, Arango Barrientos.

2010-12-01

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Coagulación intravascular diseminada = Disseminated intravascular coagulation  

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Full Text Available La coagulación intravascular diseminada (CID es una entidad clínica frecuente que se presenta como fenómeno secundario a diversas enfermedades entre las cuales se destacan las infecciones graves, las neoplasias y las catástrofes obstétricas. Se caracteriza por una activación difusa y simultánea de los sistemas endógenos de la coagulación y la fibrinólisis. El depósito de pequeños trombos en la circulación conduce finalmente a disfunción orgánica múltiple y en algunos casos a la muerte. Las manifestaciones clínicas pueden incluir fenómenos trombóticos y hemorrágicos. Se ha propuesto un puntaje de fácil aplicación para simplificar el diagnóstico de la entidad. El tratamiento incluye el control específico de la causa subyacente que favorece la aparición de la CID, el soporte con hemoderivados en pacientes con manifestaciones de sangrado y la anticoagulación terapéutica en pacientes con trombosis mayores. El desarrollo de CID es un factor pronóstico adverso que aumenta significativamente la tasa de mortalidad. En este artículo de revisión se incluyen los siguientes aspectos de la CID: historia, epidemiología, clasificación, entidades asociadas, fisiopatología, clínica, diagnóstico, tratamiento y pronóstico.

Arango Barrientos, Marcos

2010-12-01

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Linfoma Primario de Páncreas / Primary Lymphoma of Pancreas  

Scientific Electronic Library Online (English)

Full Text Available SciELO Peru | Language: Spanish Abstract in spanish Los linfomas de páncreas primarios son muy raros, reportamos un caso de un varón de 29 años tratado y diagnosticado en el hospital Daniel A. Carrión. Presentó como síntomas iniciales ictericia marcada y dolor abdominal. Las imágenes ecográficas y tomográficas muestran masa en cabeza de páncreas por [...] lo que se realizo procedimiento quirúrgico ( duodenopancreatectomía). Macroscópicamente presentaba masa bien delimitada de 5 cm de diámetro de color blanquecino. Microscópicamente se evidenció linfocitos atípicos correspondiente a Linfoma difuso de células B grandes, CD20 +, CD3 -, ACE -, CD45 + sin enfermedad extrapancreatica. Se presenta el caso y revisión de la literatura Abstract in english Páncreas lymphoma is very rare, we report a 29 years old man, treated at Daniel A. Carrion Hospital. He presented jaudince and abdominal pain . Ecography and tomography showed a mass in páncreas head . the patient underwent pancreaticoduodenectomy. The final diagnosis was Large B cell diffuse lympho [...] ma. CD 20 +, CD3 -, CD45 + without extrapancreatic disease, ACE -. We report the case and literature review.

Violeta, Aragón Carrasco; Luís, Rivas Miñope; Dina, Carayhua Pérez; Gabriela, Vegas Navarro.

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Linfomatosis intravascular de presentación pulmonar / Intravascular lymphomatosis presenting in the lung  

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Full Text Available SciELO Spain | Language: Spanish Abstract in spanish Se presenta un caso de linfomatosis intravascular cuyas primeras manifestaciones clínicas fueron síntomas pulmonares (tos no productiva, hipoxia y patrón radiológico reticulointersticial), seguidas de fiebre de origen desconocido y síndrome confusional. El diagnóstico se obtuvo mediante estudio hist [...] ológico e inmunohistoquímico postmortem, observándose en el pulmón tabiques alveolares engrosados por la presencia de células atípicas en el interior de los capilares que también ocupaban las luces de pequeños vasos, evidenciándose de forma aislada salida de las mismas al estroma fibroso perivascular y peribronquial. Las técnicas inmunohistoquímicas sobre cortes en parafina revelaron en las células tumorales positividad para CD45 (Antígeno Leucocitario Común) y para CD20 (Marcador Pan-B), siendo negativas para CD45-Ro (Marcador Pan-T) y para el marcador endotelial CD34, inmunofenotipo de Linfoma Difuso Angiotropo de Células Grandes B, confirmándose por reordenación de cadenas pesadas de inmunoglobulinas (IgH). Se revisan las características principales de esta entidad, en especial sus manifestaciones pulmonares y la necesidad de incluirla en el diagnóstico diferencial procesos de apariencia clínica sistémica. Abstract in english A case of intravascular lymphomatosis with predominant symptoms in the lung (cough and interstitial pulmonary infiltrates) is presented. Fever and confusion were lateness symptoms. Examination postmortem established the diagnosis. In the lung alveolar walls, small arterioles and the capillaries were [...] occupied by atypical cells positives for CD45 and CD20, leukocyte and pan-B markers, and negatives for CD45-Ro and CD34, pan-T and endothelial markers. The main characteristics and the lung participation of this entity were reviewed.

J.M., Sastre; R., Folgado; O., Burges; Mª.D., Zaragoza; V., Oliver.

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Linfoma primario de pulmón: Serie de casos / Primary pulmonary lymphoma: A case serie  

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Full Text Available SciELO Chile | Language: Spanish Abstract in spanish Los linfomas primarios de pulmón (LPP) son infrecuentes. Sus manifestaciones clínicas y las imágenes son inespecíficas. El retraso diagnóstico puede ser considerable. Objetivo: Analizar los LPP durante el período 2003-2013 en nuestra institución. Sobre 1892 linfomas, 4 fueron LPP (0,21%): 1) linfoma [...] no Hodgkin (n = 2); 2) linfoma Hodgkin (n= 1); 3) linfoma intravascular pulmonar (n = 1). Las manifestaciones clínicas y radiológicas fueron inespecíficas (masa pulmonar y derrame pleural, consolidación con broncograma aéreo y cavitación o bien ausencia de lesiones). Los métodos diagnósticos fueron: 1) punción guiada bajo TAC; 2) videotoracoscopía (VATS) y 3) VATS orientada por PET (tomografia por emisión de positrones) y 4) toracotomía. El tiempo entre la consulta inicial hasta el diagnóstico fue de 45 a 90 días. Este reporte confirma la baja incidencia de LPP, y sus manifestaciones clínicas y radiologías poco específicas. Esto puede contribuir a las demoras en el diagnóstico. El PETpuede mejorar el rendimiento diagnóstico, en especial en ausencia de compromiso pulmonar radiológico evidente. Abstract in english Primary Pulmonary Lymphomas (LPP) are infrequent and their clinical manifestations and images are usually nonspecific. Diagnostic delay may be important. The objective of this study was to analyze the LLP in our institution. Between 2003 and 2013, over 1,892 lymphomas were analyzed in our institutio [...] n. Only 4 of them (0.21% incidence) were detected as LPP: Non Hodgkin's Lymphoma (n = 2), Hodgkin's Lymphoma (n = 1), and Intravascular Pulmonary Lymphoma (n = 1). Clinical manifestations of the 4 cases presented were unspecific: 1) pulmonary mass and pleural effusion; 2) consolidation with air bronchogram and cavitations; 3) normal images and 4) pulmonary mass. Given these clinical settings, 4 diagnostic methods were used: 1) Computed Tomography-Guided Puncture, 2) Video-Assisted Thoracoscopic Surgery (VATS); 3) VATS guided by positron emission tomography (PET) and 4) thoracotomy. Hence, diagnosis was successfully made between 45 to 90 days from the initial consultation. This report confirms the low incidence of LPP, and its unspecific clinical and radiographic manifestations that may cause delay in diagnosis. PET can contribute to improve diagnostic performance, especially in patients without apparent lung involvement.

JULIO C, VILLARROEL S; MÁXIMO, ROMANCZUK; ESTEBAN J, WAINSTEIN; MARCOS, LAS HERAS; EDUARDO L, DE VITO; GRACIELA, SVETLIZA; JUAN A, PRECERUTTI.

2014-03-01

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Linfoma primario de pulmón: Serie de casos / Primary pulmonary lymphoma: A case serie  

Scientific Electronic Library Online (English)

Full Text Available SciELO Chile | Language: Spanish Abstract in spanish Los linfomas primarios de pulmón (LPP) son infrecuentes. Sus manifestaciones clínicas y las imágenes son inespecíficas. El retraso diagnóstico puede ser considerable. Objetivo: Analizar los LPP durante el período 2003-2013 en nuestra institución. Sobre 1892 linfomas, 4 fueron LPP (0,21%): 1) linfoma [...] no Hodgkin (n = 2); 2) linfoma Hodgkin (n= 1); 3) linfoma intravascular pulmonar (n = 1). Las manifestaciones clínicas y radiológicas fueron inespecíficas (masa pulmonar y derrame pleural, consolidación con broncograma aéreo y cavitación o bien ausencia de lesiones). Los métodos diagnósticos fueron: 1) punción guiada bajo TAC; 2) videotoracoscopía (VATS) y 3) VATS orientada por PET (tomografia por emisión de positrones) y 4) toracotomía. El tiempo entre la consulta inicial hasta el diagnóstico fue de 45 a 90 días. Este reporte confirma la baja incidencia de LPP, y sus manifestaciones clínicas y radiologías poco específicas. Esto puede contribuir a las demoras en el diagnóstico. El PETpuede mejorar el rendimiento diagnóstico, en especial en ausencia de compromiso pulmonar radiológico evidente. Abstract in english Primary Pulmonary Lymphomas (LPP) are infrequent and their clinical manifestations and images are usually nonspecific. Diagnostic delay may be important. The objective of this study was to analyze the LLP in our institution. Between 2003 and 2013, over 1,892 lymphomas were analyzed in our institutio [...] n. Only 4 of them (0.21% incidence) were detected as LPP: Non Hodgkin's Lymphoma (n = 2), Hodgkin's Lymphoma (n = 1), and Intravascular Pulmonary Lymphoma (n = 1). Clinical manifestations of the 4 cases presented were unspecific: 1) pulmonary mass and pleural effusion; 2) consolidation with air bronchogram and cavitations; 3) normal images and 4) pulmonary mass. Given these clinical settings, 4 diagnostic methods were used: 1) Computed Tomography-Guided Puncture, 2) Video-Assisted Thoracoscopic Surgery (VATS); 3) VATS guided by positron emission tomography (PET) and 4) thoracotomy. Hence, diagnosis was successfully made between 45 to 90 days from the initial consultation. This report confirms the low incidence of LPP, and its unspecific clinical and radiographic manifestations that may cause delay in diagnosis. PET can contribute to improve diagnostic performance, especially in patients without apparent lung involvement.

JULIO C, VILLARROEL S; MÁXIMO, ROMANCZUK; ESTEBAN J, WAINSTEIN; MARCOS, LAS HERAS; EDUARDO L, DE VITO; GRACIELA, SVETLIZA; JUAN A, PRECERUTTI.

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QUIMIOTERAPIA COMBINADA NEOADYUVANTE SEGUIDA DE RADIOTERAPIA EXTERNA EN EL TRATAMIENTO DE DOS CASOS DE LINFOMA PRIMARIO DEL CUELLO UTERINO  

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Los linfomas primarios del cuello uterino son poco frecuentes. Dado que no hay esquemas de manejo definido, presentamos 2 nuevos casos tratados y controlados desde 1999 a la fecha en la Fundación Arturo López Pérez. El tratamiento consistió en quimioterapia combinada neoadyuvante seguida de radioterapia externa. Se verificó respuesta clínica y radiológica completa en ambos casos. Conclusión: Se puede lograr respuesta completa de estas neoplasias linfoides con esta modalidad de tratami...

Marco Bravo S.; Fernando Heredia M; Mateo Pierotic C.

2005-01-01

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Transfusión intrauterina intravascular  

Scientific Electronic Library Online (English)

Full Text Available SciELO Venezuela | Language: Spanish Abstract in spanish Objetivo: Evaluar los resultados de 90 transfusiones intrauterinas intravasculares realizadas en 45 fetos afectados por aloinmunización Rh. Método: Descripción del procedimiento de transfusiones intrauterinas intravasculares y presentación de la evaluación y seguimiento prospectivo de 90 transfusion [...] es llevadas a cabo entre el período 1995- 2002. Ambiente: Unidad de Alto Riesgo del Servicio de Prenatal de la Maternidad “Concepción Palacios”. Caracas. Resultados: La edad promedio de las pacientes fue 25,8 años; se realizaron en promedio 2 transfusiones por paciente, con un mínimo de 1 y un máximo de 4; la mayoría de las pacientes tenían antecedentes de importancia como mortinato anterior e historia de enfermedad hemolítica; la principal indicación para realizar la el procedimiento fue la lectura de densidad óptica seguida por el hidrops fetal; la edad promedio para realizar la primera transfusión fue de 25,6 semanas con un mínimo de 20 semanas; los valores de hemoglobina fetal previa a la primera oscilaron entre 2 y 11,3 g/dL ascendiendo posterior a la transfusión a valores entre 5 y 15,3 g/dL; la sobrevida total fue de 69 % y al analizar sólo los fetos sin hidrops la sobrevida ascendió a 84,37 %. Conclusiones: La prevención con el uso de inmunoglobulina anti Rh D es definitivamente el mejor protocolo para evitar la anemia fetal por aloinmunización Rh, cuando se produce la enfermedad hemolítica intrauterina el mejor tratamiento es la reposición de sangre a través del cordón umbilical. En nuestro trabajo confirmamos que se debe adquirir una amplia experiencia en el manejo de las transfusiones intrauterinas para de esta forma prolongar la vida intrauterina y así alcanzar mayor madurez y probabilidad de sobrevida neonatal con menores riesgos y complicaciones. Abstract in english Objective: To present the results of 90 intrauterine intravascular transfusions performed in 45 Rh isoinmunized fetuses. Method: Description of the intrauterine intravascular transfusion´s procedure and presentation of evaluation and prospective floow up of 90 transfusions practiced from 1995 to 200 [...] 2. Setting: High Risk Unit of Prenatal Service at Maternidad Concepción Palacios. Caracas. Results: The mean age of patients was 25.8 years; the number of transfusions ranged from one to tour (the mean was two); most patients had important records of fetal death and hemolytic disease; transfusion was mainly prescribed after optical density values followed by fetal hydrops. Gestational age for the first procedure was 25.6 weeks with a minimum of 20 weeks; fetal haemoglobin values prior to the first transfusion ranged between 2-11.3 g/dL increasing to 5-15.3 g/dL post transfusion. Total survival was 69 % and increased to 84.37 % in the nonhydropic group. Conclusion: Prevention using antiRhD inmunoglobulin is definitively the best protocol when avoiding fetal anaemia due to Rh isoimmunization. When intrauterine hemolytic disease occurs, blood transfusion through umbilical cord seems to be the best option. In our experience, we confirmed that the accumulation of experience in intrauterine intravascular transfusion is needed in order to extend intrauterine life and so achieve a higher neonatal outcome along with less risk and complications.

Freddy, González Arias; Iván, Paravisini; Jazmín, Morales; Nelly, Vásquez de Martínez.

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Primary Non-Hodgkins lymphoma of the parotid gland Linfomas malignos primários nas glandulas salivares  

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Full Text Available Primary malignant lymphomas in the salivary glands are relatively rare. Clinical presentation is not characteristic and the disease is often overlooked resulting in diagnosis and treatment delays. AIM: To stress the importance of the diagnostic process and combined management, we present a series of eight patients with malignant lymphoma of the parotid who were diagnosed only after surgery and managed with radiation and chemotherapy. METHODS: Retrospective series of patients with primary malignant lymphoma of the parotid gland managed with radiotherapy and diagnostic surgical partial resection. RESULTS: After treatment completion we achieved a loco-regional control rate of 87.5%. Toxicity was charted according to the Common Toxicity Criteria and it was seen in six patients (75%. Six patients are still alive without evidence of recurrent disease in their last follow-up. CONCLUSION: Our study confirms that primary early stage Non-Hodgkin Lymphoma of the parotid gland is a disease with an excellent prognosis and a good local control rate, with minimal morbidity.Linfomas primários das glândulas salivares são relativamente raros. Sua apresentação clínica não écaracterística e, frequentemente, a doença passa despercebida, resultando em atrasos no diagnóstico e tratamento. OBJETIVO: Enfatizar a importância do diagnóstico e tratamento combinado. Apresentamos uma casuística de oito pacientes com linfoma maligno da parótida, que foram diagnosticados somente após a cirurgia e tratados com radio e quimioterapia. MÉTODOS: Estudo retrospectivo de pacientes com linfoma maligno primário da glândula parótida, tratados com radioterapia e ressecção cirúrgica parcial diagnóstica. RESULTADOS: Após a conclusão do tratamento, atingimos uma taxa de controle loco-regional de 87,5%. A toxicidade foi classificada de acordo com os Critérios Comuns de Toxicidade e afetou seis pacientes (75%. Seis pacientes ainda estão vivos, sem evidência de doença na mais recente consulta de acompanhamento. CONCLUSÃO: Nosso estudo confirma que o Linfoma primário Não-Hodgkin em estágios iniciais da glândula parótida é uma doença com excelente prognóstico e boa taxa de controle local, com mínima morbidade.

Francesco Dispenza

2011-10-01

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21 CFR 870.3375 - Cardiovascular intravascular filter.  

Science.gov (United States)

... false Cardiovascular intravascular filter. 870.3375 Section 870.3375 ...3375 Cardiovascular intravascular filter. (a) Identification. A cardiovascular intravascular filter is an implant that is placed in...

2010-04-01

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Linfoma de ovario Ovarian lymphoma  

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Full Text Available Introducción: el 50 % de la patología oncológica en pediatría corresponde a masas o tumores sólidos, alrededor del 20 % del total se ubica en abdomen. Los tumores que se presentan con mayor frecuencia en el abdomen son el nefroblastoma o tumor de Wilms, el linfoma tipo Burkitt, el neuroblastoma y los tumores germinales de ovario. Objetivo: presentar un caso pediátrico con tumor abdominal. Caso clínico: se presenta un caso de una niña de 8 años de edad con antecedentes de salud aparente, atendida en el Hospital Público de la Universidad de Mbarara, Uganda. Resultado: paciente pediátrica que fue ingresada con una historia de 3 meses de dolor abdominal, pérdida ligera de peso y masa abdominal de crecimiento rápido, fue sometida a una laparotomía exploradora donde se resecó la masa tumoral, la que histológicamente arrojó ser un linfoma ovárico, como hallazgo durante la intervención quirúrgica se diagnosticó una agenesia de útero. Conclusión: la paciente se encuentra después del tratamiento con quimioterapia en seguimiento, lleva aparentemente hace 5 meses una vida normal (noviembre 2011.Introduction: 50 % of pediatric oncologic pathology corresponds to mass or solid tumors, reaching about 20 % of total abdomen. The tumors that most frequently occur in the abdomen are nephroblastoma or Wilms tumor, Burkitt's lymphoma, neuroblastoma, and ovarian germ cell tumors. Objective: to present a pediatric case with abdominal tumor. Case report: we report a case of an 8 year old girl with a history of apparent good health. This patient was assisted the Public Hospital of Mbarara University, Uganda. Result: a female pediatric patient was admitted with a 3-month history of abdominal pain, mild weight loss, and rapid growth of an abdominal mass. This patient underwent an exploratory laparotomy where the tumor mass was removed. It was histologically confirmed as an ovarian lymphoma. It was diagnosed uterus agenesis. Conclusion: after chemotherapy, the patient is controlled, and she has an apparently normal life for already 5 months (November 2011.

Iván Bonet Fonseca

2012-09-01

32

Linfomatosis intravascular cerebral como causa de demencia rápidamente progresiva: Reporte de un caso / Cerebral intravascular lymphomatosis as cause of subacute dementia: Report of a case  

Scientific Electronic Library Online (English)

Full Text Available SciELO Chile | Language: Spanish Abstract in spanish La linfomatosis intravascular cerebral es un tipo de Linfoma no Hodgkin generalmente de células B, de presentación infrecuente, curso clínico progresivo y fatal. El daño vascular es producto de oclusión de vasos de pequeño calibre por infiltración tumoral, con resultado de múltiples infartos. Las ma [...] nifestaciones neurológicas suelen ser la forma de presentación clínica inicial, caracterizadas por un amplio espectro que incluye encefalopatía subaguda, deterioro cognitivo, delirio, afasia, hemiparesia, trastornos visuales, paraplejia, parestesias y compromiso de pares craneanos. Los estudios de RNM evidencian alteraciones indistinguibles de las vasculitis del SNC. La linfomatosis intravascular debe considerarse en el diagnóstico diferencial de las demencias rápidamente progresivas y en los cuadros de multi infarto cerebral de pequeño vaso de etiología inusual y recurrente. Se presenta el caso de un paciente con demencia rápidamente progresiva, con manifestaciones neurológicas de deterioro cognitivo y enfermedad sistémica. El compromiso del SNC se expresó como encefalopatía subaguda con confusión, agitación, y crisis convulsivas, trastornos motores con reflejo cutáneo plantar extensor bilateral y compromiso cerebeloso, de curso clínico sintomático progresivo, con baja de peso y fiebre fluctuante. El paciente fue sometido a tratamiento con metilprednisolona a pesar del cual falleció. El estudio necrópsico demostró alteraciones por Linfoma no Hodgkin difuso de células B, variante intra vascular, con compromiso del cerebro, cerebelo, glándulas suprarrenales, páncreas, miocardio, tiroides, pulmón riñón e hígado. Abstract in english Cerebral Intravascular Lymphomatosis is a type of non Hodgkin Lymphoma, generally composed with B cells, its ocurrence is infrequent, clinically progressive and has a fatal course. Vascular damage is related with tumoral infiltration and small caliber occlusion, with results in multi infarcts. Neuro [...] logical symptoms and signs are frequently the first clinical manifestation, which include sub acute encephalopathy, cognitive impairment, delirium, aphasia, hemipharesis, visual disturbances, paraplegia, paresthesia and cranial nerves involvement. MRI shows images of vasculitis from CNS. Cerebral Intravascular Lymphomatosis must be considered in differential diagnosis of rapid and subacute dementias, and clinical cases with small vessel recurrent multi infarct of unusual etiology. We present the clinical case of a patient with rapid progressive dementia and systemic disease manifestation. The CNS involvement was characterized as a subacute encephalopathy, with confusion and agitation, seizures, motor disturbances, bilateral plantar extensor reflexes and cerebellar signs. The clinical symptomatic course was progressive, with weight loss and fluctuant fever. The patient had a fatal course after he was treated with Methylprednisolone. Postmortem pathologic examination revealed a diffuse non Hodgkin lymphoma of B cells, intravascular variant, with brain compromise, cerebellum, suprarenal glands, pancreas, myocardium, thyroid gland, lung kidney and the lever.

Paula, Jiménez P; Oscar, Jiménez L; Pía, García F.

2013-03-01

33

Intravascular coagulation and osteonecrosis.  

Science.gov (United States)

Current evidence suggests that intravascular coagulation (IC), an intermediary mechanism, is the most likely final common pathway by which intraosseous fat embolism causes nontraumatic osteonecrosis (ON). Stage 1A lesions (fatty osteocytic necrosis) appear to progress to classic Stage 1B lesions (ischemic degeneration of necrotic osteocytes and adipocytes) when the ischemic threshold is exceeded by absolute subchondral fat overload with insufficient local clearance of procoagulants, especially tissue thromboplastin. The result is vascular stasis, hypercoagulability, endothelial damage (by free fatty acids) and IC, especially if there is coexistent subchondral vasoconstriction and impaired secondary fibrinolysis. Osteonecrosis can be produced in animals by IC, which begins in the vulnerable subchondral microcirculation (Arthus phenomenon). Cartography (embolic scintimetry with superselective angiography) indicates early complete devascularization of the femoral head, suggesting progressive venous and retrograde arterial thrombosis. Increased plasma fibrinopeptide A and direct histologic evidence of intraosseous thromboses and peripheral hemorrhages further indicate that IC is the final pathway. Best evidence are 51 ON lesions complicating disseminated IC in eight children (Shwartzman phenomenon), with collateral histologic evidence of intraosseous thrombosis and ON. PMID:1532547

Jones, J P

1992-04-01

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Quilotórax bilateral y linfoma simultáneo en dos varones: presentación de dos casos  

Directory of Open Access Journals (Sweden)

Full Text Available Fundamento: el quilotórax es una enfermedad grave, más aún si es bilateral y de causa maligna, pero tiene tratamiento y el enfermo puede estabilizarse. Objetivo: presentar dos pacientes de interés médico y demostrar que puede esperarse buena respuesta al tratamiento . Casos Clínicos: se presentaron dos enfermos portadores de quilotórax bilateral y linfoma, ambos varones, atendidos en el hospital de forma simultánea; se realizaron los exámenes complementarios diagnósticos. El diagnóstico en ambos resultó linfoma no Ho dgkin y Hodgkin respectivamente, fueron tratados con dieta, se restringieron las grasas; tratamiento oncoespecÍfico y toracocentésis repetidas en ambos hemitórax. El primero, mejorado del derrame bilateral y síntomas inicialmente, fallece a los 11 meses po r no control de su enfermedad base. El segundo, estable de ambas afecciones a los 18 meses, en ambos casos el quilotórax se compensó y no fue necesario repetir drenaje. Se hacen análisis comparativo con otros reportes sobre todo cuando el linfoma es la cau sa etiológica, la conducta adoptada concuerda con otros estudios actualesConclusiones: los enfermos mejoraron del quilotórax bilateral, uno no estabilizó su enfermedad de base y murió, mientras el otro está asintomático. Puede obtenerse buena respuesta terapéutica.

Karina Armas Moredo

2014-01-01

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Linfoma de Hodgkin con afectación ósea: comunicación de un caso y revisión de la literatura  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish Existen pocas comunicaciones en la literatura acerca de la afectación ósea primaria por linfoma de Hodgkin. El linfoma de Hodgkin representa menos del 0'15% de los tumores malignos primarios del hueso, aunque por radiología es frecuente detectar lesiones óseas en pacientes con enfermedad de Hodgkin. [...] Comunicamos el caso de un paciente inicialmente diagnosticado de linfoma de Hodgkin en fémur izquierdo, tratado con un régimen combinado de quimioradioterapia secuencial, que permanece libre de recaída a cuatro años después, aprovechando para revisar la literatura respecto a su diagnóstico y tratamiento. Abstract in english There are few literature reports about bone primary Hodgkin's lymphoma. Hodgkin's lymphoma represents less than 0.15 % of the primary malignant bone tumors, although radiology studies frequently detect bone lesions in patients with Hodgkin's disease. We report the case of a patient that was initiall [...] y diagnosed of bone Hodgkin's lymphoma with left femur involvement. The patient was treated by a combined regime of sequential chemo-radiotherapy in our Oncology Unit. He remains relapse-free three years after diagnosis. Taking advantage of our report we reviewed the literature looking for diagnostic and treatment strategies for the process.

D., Márquez Medina; B., Márquez Lobo; M. C., Talavera Hernández; I., Blancas López-Barajas; I., Sáez Medina; J. L., García Puche.

2004-03-01

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Linfoma de Burkitt oral: relato de caso Oral Burkitt's lymphoma: case report  

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Full Text Available O linfoma de Burkitt é um raro e agressivo tipo de linfoma não-Hodgkin pobremente diferenciado. O presente relato trata de uma criança do sexo masculino, com sete anos de idade, que foi examinada na Clínica de Odontopediatria do Departamento de Odontologia da UFRN, exibindo uma massa tumoral na região de pré-molares mandibulares com mobilidade dentária. O exame radiográfico revelou uma área radiolúcida difusa e o diagnóstico histopatológico foi de linfoma de Burkitt. O paciente foi tratado por poliquimioterapia e obteve completa remissão da patologia.Burkitt's lymphoma is a poorly differentiated rare and aggressive type of non-Hodgkin's lymphoma. This article reports the case of a male child aged seven years, who was examined at the Odontopediatric Clinic of the UFRN Dentistry Department. The patient presented a tumor in the premolar region of the mandible; teeth were mobile in this region. Radiology revealed a diffuse radioluscent area which was diagnosed histopathologically as Burkitt's lymphoma. The patient was treated with polychemotherapy; complete remission of the disease was attained.

Roseana de Almeida Freitas

2008-06-01

37

Linfoma de Burkitt oral: relato de caso / Oral Burkitt's lymphoma: case report  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese O linfoma de Burkitt é um raro e agressivo tipo de linfoma não-Hodgkin pobremente diferenciado. O presente relato trata de uma criança do sexo masculino, com sete anos de idade, que foi examinada na Clínica de Odontopediatria do Departamento de Odontologia da UFRN, exibindo uma massa tumoral na regi [...] ão de pré-molares mandibulares com mobilidade dentária. O exame radiográfico revelou uma área radiolúcida difusa e o diagnóstico histopatológico foi de linfoma de Burkitt. O paciente foi tratado por poliquimioterapia e obteve completa remissão da patologia. Abstract in english Burkitt's lymphoma is a poorly differentiated rare and aggressive type of non-Hodgkin's lymphoma. This article reports the case of a male child aged seven years, who was examined at the Odontopediatric Clinic of the UFRN Dentistry Department. The patient presented a tumor in the premolar region of t [...] he mandible; teeth were mobile in this region. Radiology revealed a diffuse radioluscent area which was diagnosed histopathologically as Burkitt's lymphoma. The patient was treated with polychemotherapy; complete remission of the disease was attained.

Roseana de Almeida, Freitas; Simone Souza Lobão Veras, Barros; Lêda Bezerra, Quinderé.

38

Dosimetry in intravascular brachytherapy  

International Nuclear Information System (INIS)

Among the cardiovascular diseases responsible for deaths in the adult population in almost all countries of the world, the most common is acute myocardial infarction, which generally occurs because of the occlusion of one or more coronary arteries. Several diagnostic techniques and therapies are being tested for the treatment of coronary artery disease. Balloon angioplasty has been a popular treatment which is less invasive than traditional surgeries involving revascularization of the myocardium, thus promising a better quality of life for patients. Unfortunately, the rate of restenosis (re-closing of the vessel) after balloon angioplasty is high (approximately 30-50% within the first year after treatment).Recently, the idea of delivering high radiation doses to coronary arteries to avoid or delay restenosis has been suggested. Known as intravascular brachytherapy, the technique has been used with several radiation sources, and researchers have obtained success in decreasing the rate of restenosis in some patient populations. In order to study the radiation dosimetry in the patient and radiological protection for the attending staff for this therapy, radiation dose distributions for monoenergetic electrons and photons (at nine discrete energies) were calculated for blood vessels of diameter 0.15, o,30 and 0.45 cm with balloon and wire sources using the radiation transport code MCNP4B. Specific calculations were carried out for several candidate radionuclides as well. Two s tent sources (metallic prosthesis that put inside of patient's artery through angioplasty) employing 32 P are also simulated. Advantages and disadvantages of the various radionuclides and source geometries are discussed. The dosimetry developed here will aid in the realization of the benefits obtained in patients for this promising new technology. (author)

39

Linfoma de ovario / Ovarian lymphoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Introducción: el 50 % de la patología oncológica en pediatría corresponde a masas o tumores sólidos, alrededor del 20 % del total se ubica en abdomen. Los tumores que se presentan con mayor frecuencia en el abdomen son el nefroblastoma o tumor de Wilms, el linfoma tipo Burkitt, el neuroblastoma y lo [...] s tumores germinales de ovario. Objetivo: presentar un caso pediátrico con tumor abdominal. Caso clínico: se presenta un caso de una niña de 8 años de edad con antecedentes de salud aparente, atendida en el Hospital Público de la Universidad de Mbarara, Uganda. Resultado: paciente pediátrica que fue ingresada con una historia de 3 meses de dolor abdominal, pérdida ligera de peso y masa abdominal de crecimiento rápido, fue sometida a una laparotomía exploradora donde se resecó la masa tumoral, la que histológicamente arrojó ser un linfoma ovárico, como hallazgo durante la intervención quirúrgica se diagnosticó una agenesia de útero. Conclusión: la paciente se encuentra después del tratamiento con quimioterapia en seguimiento, lleva aparentemente hace 5 meses una vida normal (noviembre 2011). Abstract in english Introduction: 50 % of pediatric oncologic pathology corresponds to mass or solid tumors, reaching about 20 % of total abdomen. The tumors that most frequently occur in the abdomen are nephroblastoma or Wilms tumor, Burkitt's lymphoma, neuroblastoma, and ovarian germ cell tumors. Objective: to presen [...] t a pediatric case with abdominal tumor. Case report: we report a case of an 8 year old girl with a history of apparent good health. This patient was assisted the Public Hospital of Mbarara University, Uganda. Result: a female pediatric patient was admitted with a 3-month history of abdominal pain, mild weight loss, and rapid growth of an abdominal mass. This patient underwent an exploratory laparotomy where the tumor mass was removed. It was histologically confirmed as an ovarian lymphoma. It was diagnosed uterus agenesis. Conclusion: after chemotherapy, the patient is controlled, and she has an apparently normal life for already 5 months (November 2011).

Iván, Bonet Fonseca; Amnia, Díaz Anaya; Tabu, Francis; Yarine Leonell, Fajardo Tornés.

2012-09-01

40

Linfoma de ovario / Ovarian lymphoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Introducción: el 50 % de la patología oncológica en pediatría corresponde a masas o tumores sólidos, alrededor del 20 % del total se ubica en abdomen. Los tumores que se presentan con mayor frecuencia en el abdomen son el nefroblastoma o tumor de Wilms, el linfoma tipo Burkitt, el neuroblastoma y lo [...] s tumores germinales de ovario. Objetivo: presentar un caso pediátrico con tumor abdominal. Caso clínico: se presenta un caso de una niña de 8 años de edad con antecedentes de salud aparente, atendida en el Hospital Público de la Universidad de Mbarara, Uganda. Resultado: paciente pediátrica que fue ingresada con una historia de 3 meses de dolor abdominal, pérdida ligera de peso y masa abdominal de crecimiento rápido, fue sometida a una laparotomía exploradora donde se resecó la masa tumoral, la que histológicamente arrojó ser un linfoma ovárico, como hallazgo durante la intervención quirúrgica se diagnosticó una agenesia de útero. Conclusión: la paciente se encuentra después del tratamiento con quimioterapia en seguimiento, lleva aparentemente hace 5 meses una vida normal (noviembre 2011). Abstract in english Introduction: 50 % of pediatric oncologic pathology corresponds to mass or solid tumors, reaching about 20 % of total abdomen. The tumors that most frequently occur in the abdomen are nephroblastoma or Wilms tumor, Burkitt's lymphoma, neuroblastoma, and ovarian germ cell tumors. Objective: to presen [...] t a pediatric case with abdominal tumor. Case report: we report a case of an 8 year old girl with a history of apparent good health. This patient was assisted the Public Hospital of Mbarara University, Uganda. Result: a female pediatric patient was admitted with a 3-month history of abdominal pain, mild weight loss, and rapid growth of an abdominal mass. This patient underwent an exploratory laparotomy where the tumor mass was removed. It was histologically confirmed as an ovarian lymphoma. It was diagnosed uterus agenesis. Conclusion: after chemotherapy, the patient is controlled, and she has an apparently normal life for already 5 months (November 2011).

Iván, Bonet Fonseca; Amnia, Díaz Anaya; Tabu, Francis; Yarine Leonell, Fajardo Tornés.

 
 
 
 
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Primary Non-Hodgkins lymphoma of the parotid gland / Linfomas malignos primários nas glandulas salivares  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese Linfomas primários das glândulas salivares são relativamente raros. Sua apresentação clínica não écaracterística e, frequentemente, a doença passa despercebida, resultando em atrasos no diagnóstico e tratamento. OBJETIVO: Enfatizar a importância do diagnóstico e tratamento combinado. Apresentamos um [...] a casuística de oito pacientes com linfoma maligno da parótida, que foram diagnosticados somente após a cirurgia e tratados com radio e quimioterapia. MÉTODOS: Estudo retrospectivo de pacientes com linfoma maligno primário da glândula parótida, tratados com radioterapia e ressecção cirúrgica parcial diagnóstica. RESULTADOS: Após a conclusão do tratamento, atingimos uma taxa de controle loco-regional de 87,5%. A toxicidade foi classificada de acordo com os Critérios Comuns de Toxicidade e afetou seis pacientes (75%). Seis pacientes ainda estão vivos, sem evidência de doença na mais recente consulta de acompanhamento. CONCLUSÃO: Nosso estudo confirma que o Linfoma primário Não-Hodgkin em estágios iniciais da glândula parótida é uma doença com excelente prognóstico e boa taxa de controle local, com mínima morbidade. Abstract in english Primary malignant lymphomas in the salivary glands are relatively rare. Clinical presentation is not characteristic and the disease is often overlooked resulting in diagnosis and treatment delays. AIM: To stress the importance of the diagnostic process and combined management, we present a series of [...] eight patients with malignant lymphoma of the parotid who were diagnosed only after surgery and managed with radiation and chemotherapy. METHODS: Retrospective series of patients with primary malignant lymphoma of the parotid gland managed with radiotherapy and diagnostic surgical partial resection. RESULTS: After treatment completion we achieved a loco-regional control rate of 87.5%. Toxicity was charted according to the Common Toxicity Criteria and it was seen in six patients (75%). Six patients are still alive without evidence of recurrent disease in their last follow-up. CONCLUSION: Our study confirms that primary early stage Non-Hodgkin Lymphoma of the parotid gland is a disease with an excellent prognosis and a good local control rate, with minimal morbidity.

Francesco, Dispenza; Giuseppe, Cicero; Gianluca, Mortellaro; Donatella, Marchese; Gautham, Kulamarva; Carlo, Dispenza.

2011-10-01

42

Hiperplasia papilar endotelial intravascular Intravascular papillary endothelial hyperplasia  

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Full Text Available La hiperplasia endotelial papilar intravascular (PEH, también conocida como hemangioendotelioma vegetante intravascular o pseudoangiosarcoma de Masson, es una lesión vascular benigna inusual, no neoplásica, que consiste en una rara proliferación endotelial reactiva, comúnmente localizada en la piel y en los tejidos subcutáneos. Es importante remarcar los aspectos que distinguen esta entidad de otras lesiones neoplásicas para evitar tratamientos inapropiados: se diferencia del angiosarcoma por su circunscripción, la localización en un vaso, su asociación con trombosis y su arquitectura papilar sin atipia citológica significativa o áreas de crecimiento sólido. El tratamiento consiste en la completa resección de la lesión incluyendo amplios márgenes para evitar la recurrencia.The intravascular papillary endothelial hyperplasia (PEH, also known as hémangioendothéliome végétant intra-vasculaire or Masson's pseudoangiosarcoma, is an unusual benign, non-neoplastic, vascular lesion, with rare non-neoplasic reactive endothelial proliferation most commonly located in the skin or subcutaneous tissues. It is important to remark the features that can distinguish this entity from other neoplasms to avoid inappropriate treatment. Pathological characteristics that distinguish PEH from angiosarcoma could be reduced to circumscription of the lesion, location in a vessel or association with thrombus and papillary architecture without significant cytologic atypia or areas of solid growth. Treatment consists of complete resection of the tumor, including wide enough margins to avoid recurrence.

R. Fernández García-Guilarte

2009-06-01

43

Linfoma hepático primario: Evolución favorable con quimioterapia combinada con rituximab Primary hepatic lymphoma: favorable outcome with chemotherapy plus rituximab  

Directory of Open Access Journals (Sweden)

Full Text Available Comunicamos el caso de una paciente con un linfoma hepático primario tratado con éxito con quimioterapia combinada con rituximab. Utilizando los "encabezamientos estándar para búsquedas bibliográficas informatizadas" (Medical Subject Heading revisamos los casos publicados hasta la fecha de esta infrecuente entidad.This article describes the case of a patient with a non-Hodgkin primary hepatic lymphoma who was successfully treated with chemotherapy combined with rituximab. Using the Medical Subject Headings the published reports of this rare entity were reviewed.

I. Serrano-Navarro

2008-11-01

44

Linfoma hepático primario: Evolución favorable con quimioterapia combinada con rituximab / Primary hepatic lymphoma: favorable outcome with chemotherapy plus rituximab  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish Comunicamos el caso de una paciente con un linfoma hepático primario tratado con éxito con quimioterapia combinada con rituximab. Utilizando los "encabezamientos estándar para búsquedas bibliográficas informatizadas" (Medical Subject Heading) revisamos los casos publicados hasta la fecha de esta inf [...] recuente entidad. Abstract in english This article describes the case of a patient with a non-Hodgkin primary hepatic lymphoma who was successfully treated with chemotherapy combined with rituximab. Using the Medical Subject Headings the published reports of this rare entity were reviewed. [...

I., Serrano-Navarro; J. F., Rodríguez-López; R., Navas-Espejo; M. A., Pérez-Jacoiste; M. A., Martínez-González; C., Grande; S., Prieto.

2008-11-01

45

21 CFR 880.5440 - Intravascular administration set.  

Science.gov (United States)

...2010-04-01 false Intravascular administration set. 880.5440 Section 880.5440 Food...880.5440 Intravascular administration set. (a) Identification. An intravascular administration set is a device used to administer...

2010-04-01

46

Actinomicosis vs Linfoma: presentación de un caso  

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Full Text Available Fundamento: el linfoma es la proliferación monoclonal neoplásica de células linfoides en localizaciones del sistema inmunitario, que incluyen ganglios linfáticos, médula ósea, bazo, hígado y tracto gastrointestinal. Caso Clínico: se presentó el caso de Linfoma no Hodgkin linfoblástico de alto grado de malignidad, en una paciente de 36 años de edad con antecedentes de hepatitis viral, giardiasis y aborto provocado con implantación de dispositivo intrauterino, que ingresa en el servicio de terapia intensiva del Hospital Universitario Manuel Ascunce Domenech por ausencia de apetito, decaimiento y pérdida de peso de 30 libras aproximadamente en tres meses; en la exploración física inicial se encuentran grandes edemas blandos en miembros inferiores y caquexia, además de distensión abdominal. Después de una estadía prolongada y tórpida evolución, la paciente fallece.

Manuel M. Basulto Barroso

2011-01-01

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Linfoma primario de cavidades / Primary effusion lymphoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish El linfoma primario de cavidades es un linfoma no Hodgkin de fenotipo B raro, de alto grado, asociado con el virus herpes humano 8 (VHH-8), y la mayoría de los casos se dan en el seno de una infección por VIH (SIDA). El pronóstico es pobre, con una mediana de supervivencia menor a los 6 meses. Prese [...] ntamos el caso de un varón de 65 años, con una hepatopatía crónica de origen incierto, anemia hemolítica crónica y ascitis. La biopsia del peritoneo evidenció un linfoma primario de cavidades. El paciente falleció dos meses después. Abstract in english Primary effusion lymphoma is a rare high-grade B-cell non-Hodgkin's lymphoma associated with human herpesvirus 8 (HHV-8) infection, and is mostly observed in the course of HIV infection (AIDS). The prognosis is poor, with reported median survival time shorter than 6 months. We present a case of a 65 [...] -year-old man, with prior unknown origin chronic hepatopathy, chronic hemolytic anaemia, and ascitis. El biopsy of peritoneum showed a primary effusion lymphoma. The patient died two month later.

P., Khosravi Shahi; P., Sabin Domínguez; G., Pérez Manga.

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Linfoma não-Hodgkin de órbita: relato de caso / Non-Hodgkin orbital lymphoma: case report  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese O objetivo é relatar manifestação incomum de linfoma não-Hodgkin de órbita. Paciente masculino, de 75 anos, se apresentou com queixa de lacrimejamento crônico bilateral. Havia feito dacriocistorrinostomia endonasal à direita e à esquerda por duas vezes, sem sucesso. Ao exame, massas de consistência [...] fibroelástica, em topografia das "bolsas" de gordura das pálpebras inferiores e proptose axial. O paciente negava outros sintomas ou sinais sistêmicos. Hemograma sem alteração, hormônios tireoidianos normais. A tomografia computadorizada mostrava infiltrado difuso na órbita e proptose axial. Biópsia de gordura orbitária e de medula óssea diagnosticaram linfoma não-Hodgkin. O paciente foi tratado com quimioterapia, sendo em seguida submetido à cirurgia da via lacrimal bilateral, com resolução do quadro. A doença sistêmica que exigia diagnóstico e tratamento adequados para que se tivesse bom prognóstico estava mascarada pelo quadro de epífora bilateral. Abstract in english The purpose is to report an unusual case of orbital non-Hodgkin lymphoma. A 75-year-old man presented with bilateral chronic epiphora complaint and inferior eyelid tumors, axial proptosis, without previous systemic manifestation. The patient was submitted to bilateral endonasal dacryocystorhinostomy [...] twice and the epiphora complaint persisted. The inferior eyelid and bone marrow biopsy revealed non-Hodgkin lymphoma. The patient was treated with systemic chemotherapy and dacryocystorhinostomy with good resolution. The precise diagnosis and the treatment were very important to reach a good resolution of the bilateral epiphora complaint.

Cristiane do Prado, Silva; Maria Aparecida, Domingues; Silvana Artioli, Schellini; Ligia, Niero.

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Radiation nephritis and intravascular coagulation  

Energy Technology Data Exchange (ETDEWEB)

A 23 year old male with embryonal cell carcinoma of the testicle was treated with radiation, receiving 2250 rads to his abdomen twice, only once with kidney shielding. He developed acute renal failure approximately eleven months later. Associated with the renal failure were hemolytic anemia, thrombocytopenia, hypofibrinogenemia, and other evidence for intravascular coagulation. The kidney biopsy showed fibrinoid necrosis of arteries and arterioles. By electron microscopy, there was seen extensive endothelial cell damage and subendothelial electron lucent material compatible with radiation nephritis. Prednisone appeared to accelerate the renal and hematologic dysfunction and heparin is proposed as a more promising therapy.

Cogan, M.G.; Arieff, A.I.

1978-08-01

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Linfoma no Hodgkin fulminante presentándose con acidosis láctica e insuficiencia hepática aguda: reporte de caso y revisión de la literatura  

Directory of Open Access Journals (Sweden)

Full Text Available La falla hepática causada por neoplasias malignas es rara. Puede ser secundaria a cáncer hepatocelular, metástasis hepáticas, neoplasias secundarias o como complicación de agentes quimioterapéuticos. Las neoplasias hematológicas, como la leucemia, linfoma no Hodgkin y linfoma Hodgkin generalmente no causan falla hepática y más raramente aún producen falla hepática aguda fulminante. Caso clínico: se presenta un hombre de 43 años de edad con diarrea, náuseas y dolor abdominal leve de dos semanas de evolución. Fue tratado con antibióticos orales sin mejoría. Ingresó con falla hepática al departamento de urgencias en donde se lo encontró ictérico, agitado, taquicárdico e hipotenso. Tenía equimosis alrededor de los ojos y tórax, sangrado activo en sitios de venopunción y hematuria macroscópica. El abdomen estaba doloroso con hepatomegalia. Los estudios de laboratorio tenían hallazgos que correspondían a falla hepatorrenal aguda, serología para hepatitis viral negativa, anticuerpos antinucleares negativos y el panel de hierro normal. El ultrasonido abdominal mostró hepatoesplenomegalia. El paciente desarrolló hipoglucemia refractaria y mayor aumento de ácido láctico sérico. Falleció a los cinco días de su admisión. Conclusiones: la falla hepática aguda como presentación inicial de linfoma es rara. Esto puede retrasar el diagnóstico, contribuyendo al mal pronóstico de esta entidad. Establecer el diagnóstico de malignidad como causa de falla hepática aguda es difícil y requiere un alto índice de sospecha. Dado el mal pronóstico asociado con el diagnóstico tardío y los potenciales beneficios de la quimioterapia, se debe considerar al linfoma como causa de falla hepática aguda sin una etiología evidente y asociado a acidosis láctica y hepatomegalia.

Guillermo Flores Padilla

2009-01-01

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Linfoma MALT en diferentes localizaciones / MALT lymphoma in different locations  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Se describen 3 casos de pacientes con linfoma MALT, diagnosticados, tratados y seguidos en la consulta de hematología del Hospital Provincial Docente Clinicoquirúrgico "Saturnino Lora" de Santiago de Cuba, a la cual fueron remitidos por gastroenterólogos, otorrinolaringólogos y maxilofaciales de la [...] mencionada institución. Uno de los afectados presentaba una masa tumoral gástrica y en nasofaringe, aparecida en diferentes momentos; otro un tumor linfoide en el paladar duro, que recurrió en ganglios infradiafragmáticos; y un tercero un nódulo linfoide en la glándula salival parótida unilateral, con recidiva en ganglios regionales después de haber sido extirpado. Todos experimentaron una buena respuesta clínica al inicio del tratamiento convencional, pero en 2 de ellos se confirmaron reapariciones no locales del proceso morboso. Abstract in english Three cases of patients with MALT lymphoma are described, who were diagnosed, treated and followed up at the hematology department of "Saturnino Lora" Teaching Provincial Hospital in Santiago de Cuba, to which they were referred by gastroenterologists, otolaryngologists and maxillofacial specialists [...] of that institution. One of those patients presented with a nasopharyngeal and gastric mass, which appeared at different times; another patient had lymphoid tumor of the hard palate, which recurred in infradiaphragmatic lymph nodes; and a third one had a lymphoid node in the unilateral salivary parotid gland with recurrence in regional nodes after having been removed. All experienced a good clinical response at the beginning of conventional treatment, but in 2 of them non-local recurrences of the disease process were confirmed.

Ana Dolores, Izquierdo Calzado; Juan Carlos, Espinosa Expósito; José, Jardón Caballero; Jesús, Díaz Fondén; Frida Yarina, González Núñez.

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Disseminated intravascular coagulation in cats.  

Science.gov (United States)

The purpose of this study was to describe the clinical characteristics of cats with disseminated intravascular coagulation (DIC), including associated diseases and hemostatic abnormalities, and to identify risk factors for death and treatments that potentially altered outcome. Medical records for cats with DIC from 1990-2004 were evaluated retrospectively. Inclusion criteria were the presence of an underlying disorder associated with DIC and either postmortem examination findings of intravascular fibrin deposition or thrombosis, or both of 2 or more organs or coagulation profiles that meet 3 of 5 criteria: prolonged prothrombin time (PT), activated partial thromboplastin time (aPTT), presence of fibrin degradation products (FDP), low plasma fibrinogen (FIB) concentration, and thrombocytopenia (cats fulfilled the criteria for DIC. Cats ranged in age from 7 weeks to 17 years (median, 9 years). Hemorrhage was noted in 7 of 46 cats (15%). Three of 46 cats (7%) survived, whereas 43 of 46 (93%) died or were euthanized. The most common underlying disorders were lymphoma, other forms of neoplasia, pancreatitis, and sepsis. There was no association detected between outcome and signalment; underlying disease; hemorrhage; abnormalities in aPTT, FIB, FDPs, platelet count; transfusion of blood products; and heparin therapy. However, the median PT of nonsurvivors was more prolonged than in survivors (P cats can result from a variety of neoplastic, infectious, and inflammatory disorders, and is associated with a high case fatality rate. PMID:17186846

Estrin, Michael A; Wehausen, Conni E; Jessen, Carl R; Lee, Justine A

2006-01-01

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Linfoma de Burkitt abdominal / Abdominal Burkitt lymphoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish El linfoma de Burkitt es un tipo de linfoma no Hodgkin, infrecuente, que afecta principalmente a niños y adolescentes. Se presenta un adolescente masculino, blanco, de 12 años de edad y antecedentes de salud anterior, con un dolor en epigastrio, tipo cólico de pocos días de evolución, que fue increm [...] entándose, sin modificaciones con la tos, estornudos o cambios de posición ni preferencia de horario, irradiado a fosa ilíaca derecha, sin vómitos, fiebre u otra sintomatología. Se realizan estudios imagenológicos, endoscópicos e histológicos, diagnosticándole un tumor de colon, es intervenido quirúrgicamente. El linfoma de Burkitt es una rara entidad que necesita de la clínica y la combinación de varios métodos de imagen para aproximarse a la sospecha diagnóstica y representa un gran desafío, por lo que alertamos a los pediatras a sospecharlo ante los dolores abdominales y tumoraciones de abdomen. Abstract in english Burkitt's lymphoma is a type of uncommon non-Hodgkin lymphoma, affecting mainly children and adolescents. A white male teen, 12 years of age, presents with previous health record, epigastric pain, cramping of some days of length, which was increasing, unchanged coughing, sneezing or changes in posit [...] ion, irradiated to the right iliac fossa, without vomiting, fever or other symptoms. Imaging, endoscopic and histological studies were performed. He was diagnosed with a colon tumor, removed later on. Burkitt lymphoma is a rare entity that requires clinical observation and combining several imaging methods to come close to the suspected diagnosis, and represents a big challenge, so we alert pediatricians to suspect of abdominal pain and abdominal tumors.

José Ridal, González Álvarez; Miguel Ángel, Rodríguez Hernández; Alfredo, Cruz Cordero; Zenia, Rodríguez Hernández; Emilio Andrés, Rodríguez Ramirez.

2014-04-01

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Linfoma de Burkitt abdominal / Abdominal Burkitt lymphoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish El linfoma de Burkitt es un tipo de linfoma no Hodgkin, infrecuente, que afecta principalmente a niños y adolescentes. Se presenta un adolescente masculino, blanco, de 12 años de edad y antecedentes de salud anterior, con un dolor en epigastrio, tipo cólico de pocos días de evolución, que fue increm [...] entándose, sin modificaciones con la tos, estornudos o cambios de posición ni preferencia de horario, irradiado a fosa ilíaca derecha, sin vómitos, fiebre u otra sintomatología. Se realizan estudios imagenológicos, endoscópicos e histológicos, diagnosticándole un tumor de colon, es intervenido quirúrgicamente. El linfoma de Burkitt es una rara entidad que necesita de la clínica y la combinación de varios métodos de imagen para aproximarse a la sospecha diagnóstica y representa un gran desafío, por lo que alertamos a los pediatras a sospecharlo ante los dolores abdominales y tumoraciones de abdomen. Abstract in english Burkitt's lymphoma is a type of uncommon non-Hodgkin lymphoma, affecting mainly children and adolescents. A white male teen, 12 years of age, presents with previous health record, epigastric pain, cramping of some days of length, which was increasing, unchanged coughing, sneezing or changes in posit [...] ion, irradiated to the right iliac fossa, without vomiting, fever or other symptoms. Imaging, endoscopic and histological studies were performed. He was diagnosed with a colon tumor, removed later on. Burkitt lymphoma is a rare entity that requires clinical observation and combining several imaging methods to come close to the suspected diagnosis, and represents a big challenge, so we alert pediatricians to suspect of abdominal pain and abdominal tumors.

José Ridal, González Álvarez; Miguel Ángel, Rodríguez Hernández; Alfredo, Cruz Cordero; Zenia, Rodríguez Hernández; Emilio Andrés, Rodríguez Ramirez.

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Linfoma del manto / Mantle cell lymphoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish El linfoma del manto representa el 7% de los linfomas no Hodgkin del adulto. Se trata de una neoplasia de células B monomorfas de talla pequeña o mediana con núcleo irregular. Las células tumorales expresan fuertemente IgM e IgD, así como los antígenos de clase B. La proteína nuclear ciclina D1 está [...] presente en todos los casos, y es el "gold estándar" para el diagnóstico. La traslocación t(11;14) (q13;q32) en la mayoría de los casos da lugar a un reordenamiento del locus BCL-1 y una sobreexpresión del gen de ciclina D1. La mayoría de los pacientes presentan estadios avanzados. El linfoma del manto es una neoplasia incurable, pero puede ser tratada con diferentes esquemas de quimioterapia (R-Hyper-CVAD, R-CHOP, bortezomib) y los pacientes jóvenes podrían ser sometidos a quimioterapia de alta dosis y trasplante de médula ósea autólogo o alogénico. Abstract in english Mantle cell lymphoma accounts for approximately 7% of adult Non-Hodgkin Lymphomas. It is a neoplasm of monomorphous small to medium-sized B cells with irregular nuclei. The tumor cells express strong IgM and IgD, and B-cell-associated antigens. Nuclear cyclin D1 protein is present in all cases and i [...] s the gold standard for the diagnosis. The t(11;14) (q13;q32) in the majority of the cases results in rearrangement of the BCL-1 locus and overexpression of the cyclin D1 gene. Most patients present with disseminated disease. Mantle cell lymphoma is an incurable neoplasm, but it may be treated with different chemotherapy regimen (R-Hyper-CVAD, R-CHOP, bortezomib) and young patients should be considered for high-dose therapy and autologous or allogeneic bone marrow transplantation.

P., Khosravi Shahi; A., del Castillo Rueda; G., Pérez Manga.

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Linfoma angiocéntrico centrofacial / Centrofacial angiocentric lymphoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish El linfoma angiocéntrico centrofacial es una neoplasia linfoide rara, con un diagnóstico a menudo difícil, debido al cuadro clínico inespecífico y a que muchas veces son necesarias varias biopsias para llegar a un diagnóstico correcto. Se trata de un linfoma no Hodgkin(LNH) agresivo, de localización [...] preferente en el tracto respiratorio superior (sobre todo en cavidad nasal), y con un pronóstico ominoso, ya que la supervivencia media es de 12-18 meses aproximadamente(1). Predomina en orientales y sudamericanos, entre los 50-60 años de edad, y con ligera preferencia por el sexo masculino (2:1). Se presenta el caso de una paciente ecuatoriana que acude a nuestro servicio con edema hemifacial, rinorrea achocolatada y obstrucción respiratoria nasal de 1 mes de evolución, sin respuesta al tratamiento antibiótico y antiinflamatorio, que tras realizar varias pruebas diagnósticas se evidenció histológicamente la presencia de un linfoma T extranodal de tipo nasal (también llamado linfoma de células T angiocéntrico). Abstract in english The centrofacial angiocentric lymphoma is a rare lymphoid neoplasm, with an often-difficult diagnosis due to the non-specific clinical picture. On many occasions it is necessary to perform various biopsies to reach the correct diagnosis. This lymphoma is an aggressive Non-Hodgkin’s (NHL) type, which [...] is normally found in the upper respiratory tract (predominantly in the nasal cavity), and has an ominous prognosis, as the average survival rate is between 12 and 18 months (1). It is predominantly found in subjects of oriental and South American extraction, who are between the ages of 50 and 60 years and with a slight tendency towards males (2:1). This is the case study of a female Ecuadorian patient who was referred to our department with a hemifacial edema, chocolate-like rhinorrhea and nasal respiratory obstruction, which had been treated with antibiotics and anti-inflammatories for a month without success. After performing a number of diagnostic tests, it was found histologically that the patient had an extranodal T-cell lymphoma of the nasal type (also known as T-cell angiocentric lymphoma).Key words: Centrofacial angiocentric lymphoma, T-cell nasal lymphoma, lethal midline granuloma.

Beatriz, Peral Cagigal; María, Galdeano Arenas; Juan Ignacio, Crespo Pinilla; José Miguel, García Cantera; Luis Antonio, Sánchez Cuéllar; Alberto, Verrier Hernández.

2005-02-01

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Manifestaciones pulmonares en pacientes con linfomas  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Se realizó un estudio descriptivo en 88 pacientes con linfomas (25 con enfermedad de Hodgkin y 63 con linfoma no Hodgkin) atendidos en el Hospital Clinicoquirúrgico "Hermanos Ameijeiras" desde abril de 1997 hasta diciembre de 1998, para identificar las manifestaciones pulmonares. Se estudiaron los s [...] íntomas y signos del aparato respiratorio y los resultados de la radiografía del tórax en todos los pacientes. En 79 de ellos se realizaron pruebas funcionales respiratorias. Predominaron los pacientes asintomáticos (69/88; 78,4 %) (p Abstract in english A descriptive study was conducted in 88 patients with lymphomas (25 Hodgkin’s disease and 63 non-Hodgkin’s lymphoma) seen at "Hermanos Ameijeiras" Clinical and Surgical Hospital from April 1997 to December 1998. Its objective was to identify the pulmonary manifestations. Symptoms and signs of the re [...] spiratory system and chest Rx results were analyzed in all the patients. Seventy-nine of them underwent respiratory function testing. Asymptomatic patients prevailed (69/88 for 78,4 %) (p

Jesús Diego, de la Campa; José, Carnot Uría; Jorge, Muñío Perurena; Raúl, de Castro Arenas; Guillermo, Pérez Román; Lisbett, Suárez González.

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Tejido linfoide y linfomas gástricos Lymphoid tissue and gastric lymphomas  

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Full Text Available En este artículo hemos realizado una amplia revisión de los linfomas primarios gástricos, su clasificación y aspectos clínico-patológicos más importantes, haciendo énfasis especial en los linfomas MALT o asociados a las mucosas y su relación con la infección por Helicobacter pylori.In this review we describe various aspects of the primary gastric lymphomas, the classification, and the most important clinico-pathological aspects, with emphasis in mucosa associated lymphoma (MALT and the Helicobacter pylori infection.

Rocío del Pilar López P

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Interventional and intravascular MR angiography  

International Nuclear Information System (INIS)

Magnetic resonance imaging (MRI) has a number of characteristics which make it attractive for guidance of intravascular therapeutic procedures, including high soft tissue contrast, imaging in any arbitrary oblique plane, lack of ionizing radiation, and the ability to provide functional information, such as flow velocity and volume per unit time. For MR guidance of vascular interventions to be safe, catheters and guidewires must be visualized relative to the vascular system and surrounding tissues. A number of approaches for making instruments visible in an MR environment are presented, including both passive and active techniques. Passive techniques depend on contrast agents or susceptibility artifacts, whereas active techniques, including MR tracking, MR profiling, and active field inhomogeneity, use some form of electrical coil built into the instrument. The potential for obtaining high-resolution images of the vessel wall using coils built into a catheter is also discussed. These images provide the capability to distinguish and identify various plaque components. The additional capabilities of MRI could potentially open up new applications beyond those currently performed under X-ray fluoroscopic guidance. (orig.)

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Periprostatic subendothelial intravascular granulomatosis: a mimic of high-grade intravascular prostatic adenocarcinoma.  

Science.gov (United States)

A rare case of intravascular granulomatous inflammation mimicking intravascular prostatic adenocarcinoma is reported. To the author's knowledge, there have been no previous reports of prostatic or periprostatic intravascular granulomatous inflammation. A 67-year-old man presented with elevated serum prostate specific antigen (PSA) and was found to have a high-grade adenocarcinoma of the prostate. A radical prostatectomy revealed intravascular subendothelial granulomatous inflammation mimicking vascular invasion of a high-grade adenocarcinoma found elsewhere in the prostate. Immunoperoxidase stains confirmed that the subendothelial infiltrate was composed of histiocytes and not tumor cells. Periprostatic subendothelial intravascular granulomatosis is a rare event, which may mimic vascular involvement of high-grade prostatic adenocarcinoma and may result from a previous needle biopsy of the prostate. Possible mechanisms for this finding are discussed. It is important to distinguish this process from high-grade prostatic adenocarcinoma involving blood vessels for obvious clinical reasons. PMID:14765279

Crawford, Byron E; Daroca, Philip J; Davis, Rodney

2004-01-01

 
 
 
 
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Dosimetry in intravascular brachytherapy; Calculos dosimetricos em braquiterapia intravascular  

Energy Technology Data Exchange (ETDEWEB)

Among the cardiovascular diseases responsible for deaths in the adult population in almost all countries of the world, the most common is acute myocardial infarction, which generally occurs because of the occlusion of one or more coronary arteries. Several diagnostic techniques and therapies are being tested for the treatment of coronary artery disease. Balloon angioplasty has been a popular treatment which is less invasive than traditional surgeries involving revascularization of the myocardium, thus promising a better quality of life for patients. Unfortunately, the rate of restenosis (re-closing of the vessel) after balloon angioplasty is high (approximately 30-50% within the first year after treatment).Recently, the idea of delivering high radiation doses to coronary arteries to avoid or delay restenosis has been suggested. Known as intravascular brachytherapy, the technique has been used with several radiation sources, and researchers have obtained success in decreasing the rate of restenosis in some patient populations. In order to study the radiation dosimetry in the patient and radiological protection for the attending staff for this therapy, radiation dose distributions for monoenergetic electrons and photons (at nine discrete energies) were calculated for blood vessels of diameter 0.15, o,30 and 0.45 cm with balloon and wire sources using the radiation transport code MCNP4B. Specific calculations were carried out for several candidate radionuclides as well. Two s tent sources (metallic prosthesis that put inside of patient's artery through angioplasty) employing {sup 32} P are also simulated. Advantages and disadvantages of the various radionuclides and source geometries are discussed. The dosimetry developed here will aid in the realization of the benefits obtained in patients for this promising new technology. (author)

Campos, Laelia Pumilla Botelho

2000-03-01

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Linfoma metastásico cardíaco / Metastatic Cardiac Lymphoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Argentina | Language: Spanish Abstract in spanish Los tumores cardíacos secundarios o metastásicos son unas 20-40 veces más comunes que los primitivos benignos y malignos. Las neoplasias que con más frecuencia producen metástasis en el corazón son los carcinomas pulmonares, los de mama, los melanomas malignos y, en una proporción menor, las leucosi [...] s y los linfomas. En esta presentación se describe el caso de una paciente femenina, de 36 años, con síntomas cardiovasculares de arritmia y síncope y evidencia ecocardiográfica de tumor cardíaco de crecimiento acelerado. Debido al agravamiento de las manifestaciones clínicas, se inició tratamiento con esteroides sistémicos, con el que experimentó mejoría clínica en las primeras 72 horas. Esto llevó a enfocar el diagnóstico en una causa secundaria de invasión cardíaca. Los hallazgos histopatológicos de una biopsia gástrica evidenciaron la presencia de un linfoma no Hogdkin. Se inició el tratamiento citostático específico; la paciente se encuentra en remisión y con regresión total de sus síntomas cardiovasculares. En nuestra paciente llama la atención la forma de presentación de los síntomas, que estuvieron limitados a la esfera cardiovascular pese a la localización en el sistema digestivo del tumor primario. Abstract in english Secondary or metastatic cardiac tumors are 20 to 40 times more common than primary benign or malignant neoplasms. Lung and breast carcinoma, malignant melanoma, and, to a lesser degree, leukemia and lymphoma, often metastasize to the heart. We describe the case of a 36-year old female patient with a [...] rrhythmia and echocardiographic evidence of a rapidly growing heart tumor. Treatment with systemic corticosteroids was initiated due to symptoms aggravation and the patient improved within 72 hours. A metastatic tumor was then suspected. A gastric biopsy confirmed the presence of a non-Hodgkin lymphoma. Specific cytostatic treatment was started; the patient remains in remission with complete regression of cardiovascular symptoms. Interestingly, our patient presented only cardiovascular symptoms despite the primary tumor was located in the digestive system.

Sheila, Hechavarría Pouymiró; Roberto, Marrero Mederos; Juan, Valiente Mustelier; Francisco, Cabrera.

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Uropatía obstructiva bilateral como forma de presentación de linfoma vesical primario / Bilateral obstructive uropathy as clinical presentation of primary bladder lymphoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish Objetivo: Dar a conocer un caso de presentación atípica de linfoma vesical primario tratado en nuestro hospital, así como revisar la bibliografía de este tipo de tumores, que representan el 0.2% de los tumores vesicales, siendo su forma de presentación más frecuente la hematuria macroscópica con coá [...] gulos. Métodos: Presentamos el caso de un varón de 83 años, que acudió a Urgencias por oligoanuria de 48h de evolución, en el que se diagnosticó un tumor vesical. Resultados: La anatomía patológica resulto ser un linfoma vesical primario de células B. Conclusiones: El linfoma vesical primario es una entidad poco frecuente, que cursa de forma indistinguible a otros tumores vesicales, presentando una buena respuesta al tratamiento con quimioterapia. Abstract in english Objective: We report the event of an atypical presentation of primary bladder lymphoma, treated in our hospital, and review the literature of such tumors, representing 0,2% of bladder tumors, being macroscopic hematuria with clots the most frequent reason for patient consultation. Methods: We report [...] the case of an 83 years old man who went to the emergency room because of oligoanuria of 48 hours of evolution. He was diagnosed of bladder tumor. Results: The pathology turned out to be a primary bladder lymphoma cell B. Conclusions: Primary bladder lymphoma is a rare entity that presents a similar behaviour to other bladder tumors, having a good response to treatment with chemotherapy.

David, Hernández Alcaraz; José A., Gómez Pascual; Jorge, Soler Martínez; Raúl, Vozmediano Chicharro; Pedro, Morales Jiménez; Eloy, Vivas Vargas; Víctor, Baena González.

2009-04-01

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Uropatía obstructiva bilateral como forma de presentación de linfoma vesical primario / Bilateral obstructive uropathy as clinical presentation of primary bladder lymphoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish Objetivo: Dar a conocer un caso de presentación atípica de linfoma vesical primario tratado en nuestro hospital, así como revisar la bibliografía de este tipo de tumores, que representan el 0.2% de los tumores vesicales, siendo su forma de presentación más frecuente la hematuria macroscópica con coá [...] gulos. Métodos: Presentamos el caso de un varón de 83 años, que acudió a Urgencias por oligoanuria de 48h de evolución, en el que se diagnosticó un tumor vesical. Resultados: La anatomía patológica resulto ser un linfoma vesical primario de células B. Conclusiones: El linfoma vesical primario es una entidad poco frecuente, que cursa de forma indistinguible a otros tumores vesicales, presentando una buena respuesta al tratamiento con quimioterapia. Abstract in english Objective: We report the event of an atypical presentation of primary bladder lymphoma, treated in our hospital, and review the literature of such tumors, representing 0,2% of bladder tumors, being macroscopic hematuria with clots the most frequent reason for patient consultation. Methods: We report [...] the case of an 83 years old man who went to the emergency room because of oligoanuria of 48 hours of evolution. He was diagnosed of bladder tumor. Results: The pathology turned out to be a primary bladder lymphoma cell B. Conclusions: Primary bladder lymphoma is a rare entity that presents a similar behaviour to other bladder tumors, having a good response to treatment with chemotherapy.

David, Hernández Alcaraz; José A., Gómez Pascual; Jorge, Soler Martínez; Raúl, Vozmediano Chicharro; Pedro, Morales Jiménez; Eloy, Vivas Vargas; Víctor, Baena González.

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Fluorescent Method for Observing Intravascular Bonghan Duct  

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Full Text Available Observation of intra-vascular threadlike structures in the blood vessels of rats is reported with the images by differential interference contrast microscope, and fluorescence inverted microscope of the acridine-orange stained samples. The confocal microscope image and the hematoxylin-eosin staining revealed the distinctive pattern of nuclei distribution that clearly discerned the threadlike structure from fibrin, capillary, small venule, arteriole, or lymph vessel. Physiological function of the intra-vascular thread in connection with acupuncture is discussed. Especially, this threadlike duct can be a circulation path for herb-liquid flow, which may provide the scientific mechanism for therapeutic effect of herbal acupuncture.

Byung-Cheon Lee

2005-12-01

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QUIMIOTERAPIA COMBINADA NEOADYUVANTE SEGUIDA DE RADIOTERAPIA EXTERNA EN EL TRATAMIENTO DE DOS CASOS DE LINFOMA PRIMARIO DEL CUELLO UTERINO  

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Full Text Available Los linfomas primarios del cuello uterino son poco frecuentes. Dado que no hay esquemas de manejo definido, presentamos 2 nuevos casos tratados y controlados desde 1999 a la fecha en la Fundación Arturo López Pérez. El tratamiento consistió en quimioterapia combinada neoadyuvante seguida de radioterapia externa. Se verificó respuesta clínica y radiológica completa en ambos casos. Conclusión: Se puede lograr respuesta completa de estas neoplasias linfoides con esta modalidad de tratamientoBackground: Primary extranodal lymphomas of the genital tract are rare. Cases: As there is no current consensus in its management, we present two further cases and their treatment with neoadyuvant chemotherapy, followed by radiation therapy. A radical hysterectomy with bilateral pelvic lymphadenectomy was performed after primary treatment in one case. Clinical response was complete in both cases and pathological response was documented in one. Conclusions: Complete response of these lymphoid neoplasms can be achieved by neoadyuvant chemotherapy followed by external irradiation

Marco Bravo S.

2005-01-01

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Linfoma de celulas B de la zona marginal extraganglionar del tejido linfoide asociado a mucosa (linfoma MALT de pulmón  

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Full Text Available Los Linfomas Pulmonares Primarios son extremadamente raros (0,4% de los linfomas extraganglionares, y generalmente son de tejido linfoide asociado a mucosas (tipo MALT, con ocasionales linfomas de células grandes difusos. Los síntomas son inespecíficos, y casi la mitad de los pacientes son asintomáticos. Se presenta el caso de un paciente masculino de 56 años de edad, quien presentó durante 7 meses accesos diarios de tos seca, de predominio nocturno, asociados en el último mes a fiebre de 39ºC, disnea a medianos esfuerzos y expectoración verduzca. Los exámenes de laboratorio fueron normales. La radiografía de tórax mostró el mediastino ensanchado, un proceso en lóbulo medio con efecto atelectásico, y un nódulo en hemitórax izquierdo. La tomografía computarizada (TC torácica de alta resolución evidenció proceso alveolar derecho en lóbulo medio y un nódulo pulmonar izquierdo calcificado de tipo inespecífico. El estudio inmunohistoquímico de la biopsia pulmonar fue compatible con Linfoma de Células B de la zona marginal extraganglionar del tejido linfoide asociado a mucosa (Linfoma MALT de pulmón. La TC corporal y la Tomografía por Emisión de Positrones (PET evidenciaron importantes hallazgos complementarios para determinar la extensión de la enfermedad. El paciente se trato con quimioterapia y actualmente se encuentra en buenas condiciones, sin recidiva de la sintomatología. Dado lo infrecuente de la patología se presenta este caso y se hace una revisión de la literatura

Carlos Vergara-Uzcategui

2014-09-01

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Linfoma no Hodgkin de células T: una nueva visión  

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Full Text Available Los linfomas no Hodgkin de células T, son enfermedades malignas poco comunes. La clasificación actual WHO/EORTC, reconoce 10 entidades clínico patológicas diferentes, estas entidades tiene una única característica y requieren individualizar el diagnóstico y el tratamiento de los mismos. En años recientes se han hecho grandes progresos en el conocimiento de la patogenia de estas enfermedades. La traslocación cromosomal especifica, y las infecciones virales son asociadas actualmente a ciertos linfomas. En esta revisión se describen la presentación clínico patológica, y además se discuten los estudios moleculares en diagnóstico de de los linfomas de células T, debido a la rareza de estas entidades y la escasez de investigaciones a gran escala acerca de las mismas su tratamiento aun es un reto, basado en bases anecdóticas, requiriéndose aun estudios mas extensos acerca de las bases biológicas de estas enfermedades para poder obtener terapias mas satisfactorias.

Alfredo Arredondo Bruce

2009-01-01

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Amputation neuroma growing intravascularly into a thrombus.  

Science.gov (United States)

An adult man underwent arm amputation for a sarcoma. Pain and three masses observed radiologically prompted surgical exploration five years later. Microscopically, the masses represented amputation neuromas. One of them was located in the lumen of an artery, in a remote organized thrombus. Intravascular growth of an amputation neuroma has not been described previously. PMID:24477938

Schulz, Wade L; Manivel, J Carlos

2014-10-01

70

Primary testicular non-Hodgkin's lymphoma: a review article / Linfoma primário do testículo: um artigo de revisão  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese O linfoma primário do testículo (LPT) foi descrito como uma entidade clínica pela primeira vez em 1866. É uma doença rara e corresponde a 1% de todos os linfomas não-Hodgkin, 2% de todos os linfomas extranodais e 5% de todos as neoplasias testiculares. É o tumor testicular mais comum em homens entre [...] 60 e 80 anos de idade. LPT é único em sua elevada incidência de envolvimento bilateral (8-38%), sendo o tumor testicular bilateral mais comum. Tem uma predileção por disseminação para regiões extranodais não-contíguas, especialmente para o sistema nervoso central (SNC). Estágios avançados da doença são usualmente tratados com quimioterapia à base de doxorubicina. Para os estágios mais precoces, as opiniões são divergentes quanto à quimioterapia associada à orquiectomia. A alta prevalência de disseminação, especialmente para o SNC, sugere o uso de quimioterapia intratecal como profilaxia. Estudos prospectivos multicêntricos incluindo um grande número de pacientes poderiam resolver a questão com relação ao manejo deste subtipo de linfoma não-Hodgkin. Abstract in english Primary testicular non-Hodgkin's lymphoma was first described as a clinical entity in 1866. It is a rare disease and accounts for 1% of all non-Hodgkin's lymphoma, 2% of all extranodal lymphomas and 5% of all testicular neoplasms. It is the most common testicular tumor in males between sixty and eig [...] hty years of age. Testicular non-Hodgkin's lymphoma is unique in its high incidence of bilateral involvement (8-38%), and it is also the most common bilateral testicular tumor. Testicular non-Hodgkin's lymphoma has a predilection for spreading to non-contiguous extranodal sites, especially the central nervous system. Advanced-stage disease is usually managed with doxorubicin-based chemotherapy. For early-stage disease, opinion is divided regarding systemic chemotherapy following orchidectomy. The high incidence of spreading, especially to the central nervous system, leads to advocacy of the use of central nervous system prophylaxis with intrathecal chemotherapy. Prospective multicenter trials incorporating a large number of patients may lead to better guidelines for optimal management of this subtype of non-Hodgkin's lymphoma.

Komal, Bhatia; Ashok Kumar, Vaid; Sachin, Gupta; Dinesh Chandra, Doval; Vineet, Talwar.

71

Primary testicular non-Hodgkin's lymphoma: a review article / Linfoma primário do testículo: um artigo de revisão  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese O linfoma primário do testículo (LPT) foi descrito como uma entidade clínica pela primeira vez em 1866. É uma doença rara e corresponde a 1% de todos os linfomas não-Hodgkin, 2% de todos os linfomas extranodais e 5% de todos as neoplasias testiculares. É o tumor testicular mais comum em homens entre [...] 60 e 80 anos de idade. LPT é único em sua elevada incidência de envolvimento bilateral (8-38%), sendo o tumor testicular bilateral mais comum. Tem uma predileção por disseminação para regiões extranodais não-contíguas, especialmente para o sistema nervoso central (SNC). Estágios avançados da doença são usualmente tratados com quimioterapia à base de doxorubicina. Para os estágios mais precoces, as opiniões são divergentes quanto à quimioterapia associada à orquiectomia. A alta prevalência de disseminação, especialmente para o SNC, sugere o uso de quimioterapia intratecal como profilaxia. Estudos prospectivos multicêntricos incluindo um grande número de pacientes poderiam resolver a questão com relação ao manejo deste subtipo de linfoma não-Hodgkin. Abstract in english Primary testicular non-Hodgkin's lymphoma was first described as a clinical entity in 1866. It is a rare disease and accounts for 1% of all non-Hodgkin's lymphoma, 2% of all extranodal lymphomas and 5% of all testicular neoplasms. It is the most common testicular tumor in males between sixty and eig [...] hty years of age. Testicular non-Hodgkin's lymphoma is unique in its high incidence of bilateral involvement (8-38%), and it is also the most common bilateral testicular tumor. Testicular non-Hodgkin's lymphoma has a predilection for spreading to non-contiguous extranodal sites, especially the central nervous system. Advanced-stage disease is usually managed with doxorubicin-based chemotherapy. For early-stage disease, opinion is divided regarding systemic chemotherapy following orchidectomy. The high incidence of spreading, especially to the central nervous system, leads to advocacy of the use of central nervous system prophylaxis with intrathecal chemotherapy. Prospective multicenter trials incorporating a large number of patients may lead to better guidelines for optimal management of this subtype of non-Hodgkin's lymphoma.

Komal, Bhatia; Ashok Kumar, Vaid; Sachin, Gupta; Dinesh Chandra, Doval; Vineet, Talwar.

2007-09-01

72

Mapping intravascular ultrasound controversies in interventional cardiology practice.  

Science.gov (United States)

Intravascular ultrasound is a catheter-based imaging modality that was developed to investigate the condition of coronary arteries and assess the vulnerability of coronary atherosclerotic plaques in particular. Since its introduction in the clinic 20 years ago, use of intravascular ultrasound innovation has been relatively limited. Intravascular ultrasound remains a niche technology; its clinical practice did not vastly expand, except in Japan, where intravascular ultrasound is an appraised tool for guiding percutaneous coronary interventions. In this qualitative research study, we follow scholarship on the sociology of innovation in exploring both the current adoption practices and perspectives on the future of intravascular ultrasound. We conducted a survey of biomedical experts with experience in the technology, the practice, and the commercialization of intravascular ultrasound. The collected information enabled us to map intravascular ultrasound controversies as well as to outline the dynamics of the international network of experts that generates intravascular ultrasound innovations and uses intravascular ultrasound technologies. While the technology is praised for its capacity to measure coronary atherosclerotic plaque morphology and is steadily used in clinical research, the lack of demonstrated benefits of intravascular ultrasound guided coronary interventions emerges as the strongest factor that prevents its expansion. Furthermore, most of the controversies identified were external to intravascular ultrasound technology itself, meaning that decision making at the industrial, financial and regulatory levels are likely to determine the future of intravascular ultrasound. In light of opinions from the responding experts', a wider adoption of intravascular ultrasound as a stand-alone imaging modality seems rather uncertain, but the appeal for this technology may be renewed by improving image quality and through combination with complementary imaging modalities. PMID:24816741

Maresca, David; Adams, Samantha; Maresca, Bruno; van der Steen, Antonius F W

2014-01-01

73

Techniques for Intravascular Foreign Body Retrieval  

International Nuclear Information System (INIS)

As endovascular therapies increase in frequency, the incidence of lost or embolized foreign bodies is increasing. The presence of an intravascular foreign body (IFB) is well recognized to have the potential to cause serious complications. IFB can embolize and impact critical sites such as the heart, with subsequent significant morbidity or mortality. Intravascular foreign bodies most commonly result from embolized central line fragments, but they can originate from many sources, both iatrogenic and noniatrogenic. The percutaneous approach in removing an IFB is widely perceived as the best way to retrieve endovascular foreign bodies. This minimally invasive approach has a high success rate with a low associated morbidity, and it avoids the complications related to open surgical approaches. We examined the characteristics, causes, and incidence of endovascular embolizations and reviewed the various described techniques that have been used to facilitate subsequent explantation of such materials

74

Techniques for Intravascular Foreign Body Retrieval  

Energy Technology Data Exchange (ETDEWEB)

As endovascular therapies increase in frequency, the incidence of lost or embolized foreign bodies is increasing. The presence of an intravascular foreign body (IFB) is well recognized to have the potential to cause serious complications. IFB can embolize and impact critical sites such as the heart, with subsequent significant morbidity or mortality. Intravascular foreign bodies most commonly result from embolized central line fragments, but they can originate from many sources, both iatrogenic and noniatrogenic. The percutaneous approach in removing an IFB is widely perceived as the best way to retrieve endovascular foreign bodies. This minimally invasive approach has a high success rate with a low associated morbidity, and it avoids the complications related to open surgical approaches. We examined the characteristics, causes, and incidence of endovascular embolizations and reviewed the various described techniques that have been used to facilitate subsequent explantation of such materials.

Woodhouse, Joe B.; Uberoi, Raman, E-mail: raman.uberoi@orh.nhs.uk [Oxford University Hospitals (United Kingdom)

2013-08-01

75

Temporary intravascular shunts for peripheral vascular trauma.  

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Full Text Available Polyvinylchloride (PVC disposable endotracheal suction catheters were successfully used as temporary intravascular shunts in 5 patients of popliteal artery trauma. These simple shunts should be used routinely in such conditions to immediately re-establish blood supply to the ischaemic limb particularly in patients of polytrauma where systemic anticoagulation is contraindicated. This avoids the inherent delay prior to vascular repair and reduces the incidence of irreversible ischemia.

Husain A

1992-04-01

76

Contrast enhanced intravascular ultrasound chirp imaging  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Intravascular ultrasound (IVUS) imaging in combination with a microbubble ultrasound contrast agent (UCA) has the potential to image microvascular networks within the coronary artery wall, also referred to as vasa vasorum (VV). We report the relative performance of three chirp-based UCA detection methods at IVUS frequencies (30 to 60 MHz) for VV imaging: pulse inversion, subharmonic emission and chirp reversal. The contrast to tissue ratio, the contrast to noise ratio and the artifacts of eac...

Maresca, David; Renaud, Guillaume; Jong, Nico; Steen, Ton

2012-01-01

77

LINFOMA T DE TIPO ANGIOINMUNOBLASTICO: ESTUDIO CLÍNICO-PATOLÓGICO DEL GRUPO DE ESTUDIO DE LINFOMAS DE JUJUY (GELJ  

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Full Text Available ABSTRACTJujuy have a high incidence of lymphomas and among these a high number of T-cell lymphomas is observed. However the Angioimmunoblastic T-cell Lymphoma once a best characterized T-cell lymphomas, was not studied in Jujuy in both, incidence and clinicopathologic features. These lymphoma present a characteristic clinical findings and a distinctive histopathological picture with T-cell immunophenotype that permit a clear differentiation from other peripheral T-cell lymphomas.Angioimmunoblastic Peripheral T-cell lymphoma represent the 9,1% of our cases of lymphomas, registered between 1985 and July 2004, when we consider nodal and extranodal cases, but represent 18% among the nodal lymphomas. All the cases studied presenting the distinctive histopathologic picture, with effacement of the lymph node architecture, absence of germinal centers, polymorphic cytology, marked increase of arborizing vessel PAS-positive and accumulations of Follicular Dendritic Reticular Cells, CD21+. Clinically we observed generalized lymphadenopaty, skin lesions, pulmonary manifestations, systemic symptoms and aggressive behavior.RESUMEN:Jujuy es una zona de alta incidencia de linfomas y entre ellos se registra un elevado número de linfomas de células T. Pese a esto el linfoma T tipo linfadenopatía Angioinmunoblastica, uno de los mejor caracterizados linfomas de células T, no ha sido estudiado, tanto en su incidencia, como en sus caracteres clínico-patológicos. Estos linfomas presentan un cuadro clínico característico y un distintivo cuadro histopatológico e inmunofenotípico, que permiten su diferenciación de otros tipos de linfomas T.Este linfoma representa el 9,1% de los casos registrados en nuestro hospital entre 1985 y julio de 2004, cuando se consideran casos ganglionares y extraganglionres y el 18% de los casos ganglionares. Presentan el característico cuadro histopatológico con borramiento de la histoarquitectura ganglionar linfática, citología polimorfa, marcado incremento de vénulas postcapilares y mantos de células reticulares dendríticas positivas para CD21. Clínicamente se observó poliadenopatía generalizada, lesiones cutáneas, manifestaciones pulmonares, fenómenos alérgicos, síntomas sistémicos, estadio avanzado de enfermedad y una agresiva evolución clínica

Ana Carolina Ituarte

2005-01-01

78

Primary lymphoma of the colon / Linfoma primario de colon  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: English Abstract in spanish Introducción: el linfoma primario de colon y recto es una patología poco prevalente, representa tan solo el 0,5 % de todas las neoplasias primarias de colon y recto. El tracto gastrointestinal es el lugar donde asientan la gran mayoría de los linfomas extranodales, siendo el más frecuente el tipo li [...] nfoma no-Hodking. El diagnóstico precoz es siempre difícil debido a que la sintomatología es muy poco específica. Los algoritmos terapéuticos han incluido clásicamente la resección radical, el tratamiento con quimioterapia y con radioterapia. Materiales y métodos: presentamos nuestra experiencia en el manejo de los linfomas primarios de colon en un periodo de 17 años (1994-2011). Resultados: en dicho periodo en nuestro centro fueron diagnosticaron 7 casos de linfoma primario de colon. El dolor abdominal y los cambios en el ritmo deposicional fueron los síntomas más frecuentes. Cinco pacientes requirieron tratamiento quirúrgico urgente debido a hemorragia digestiva u obstrucción intestinal. El estudio anatomopatológico reveló que todos los linfomas tenían el fenotipo de tipo B. Los pacientes tuvieron un seguimiento medio de 59 meses (rango 1-180). Tres de ellos siguen vivos sin evidencia de recidiva. Conclusión: el tratamiento combinado con quimioterapia y cirugía puede obtener buenos resultados de remisión. La cirugía puede resolver complicaciones como la hemorragia o la perforación intestinal, ambas directamente relacionadas con la mortalidad por linfoma. Abstract in english Background: primary colorectal lymphoma is a very rare disease, representing less than 0.5 % of all primary colorectal neoplasms. The gastrointestinal tract is the most frequently involved site of all extranodal lymphomas, the most common type of that is non-Hodgkin's lymphoma. Early diagnosis is of [...] ten difficult because of unspecific symptoms. Therapeutic approaches have classically included radical resection, chemotherapy and radiotherapy. Materials and methods: we present our experience in the management of primary colorectal lymphomas over a 17-year period (1994-20011). Results: in this period 7 cases of primary colorectal lymphoma were diagnosed in our institution. Abdominal pain and change in bowel habit were the most frequent symptoms. Five patients underwent emergency surgery because of bleeding or bowel obstruction. All primary intestinal lymphomas studied were of the B-cell phenotype. Patients were followed up for a median of 59 months (range 1-180). Three of them are alive with no evidence of recurrence. Conclusion: combination treatment with chemotherapy and surgery can obtain good remission rate. Surgery can resolve complications such bleeding or intestinal perforation that are implicated in lymphoma mortality.

Marta, Pascual; Blanca, Sánchez-González; Mar, García; Miguel, Pera; Luis, Grande.

2013-02-01

79

Primary lymphoma of the colon / Linfoma primario de colon  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: English Abstract in spanish Introducción: el linfoma primario de colon y recto es una patología poco prevalente, representa tan solo el 0,5 % de todas las neoplasias primarias de colon y recto. El tracto gastrointestinal es el lugar donde asientan la gran mayoría de los linfomas extranodales, siendo el más frecuente el tipo li [...] nfoma no-Hodking. El diagnóstico precoz es siempre difícil debido a que la sintomatología es muy poco específica. Los algoritmos terapéuticos han incluido clásicamente la resección radical, el tratamiento con quimioterapia y con radioterapia. Materiales y métodos: presentamos nuestra experiencia en el manejo de los linfomas primarios de colon en un periodo de 17 años (1994-2011). Resultados: en dicho periodo en nuestro centro fueron diagnosticaron 7 casos de linfoma primario de colon. El dolor abdominal y los cambios en el ritmo deposicional fueron los síntomas más frecuentes. Cinco pacientes requirieron tratamiento quirúrgico urgente debido a hemorragia digestiva u obstrucción intestinal. El estudio anatomopatológico reveló que todos los linfomas tenían el fenotipo de tipo B. Los pacientes tuvieron un seguimiento medio de 59 meses (rango 1-180). Tres de ellos siguen vivos sin evidencia de recidiva. Conclusión: el tratamiento combinado con quimioterapia y cirugía puede obtener buenos resultados de remisión. La cirugía puede resolver complicaciones como la hemorragia o la perforación intestinal, ambas directamente relacionadas con la mortalidad por linfoma. Abstract in english Background: primary colorectal lymphoma is a very rare disease, representing less than 0.5 % of all primary colorectal neoplasms. The gastrointestinal tract is the most frequently involved site of all extranodal lymphomas, the most common type of that is non-Hodgkin's lymphoma. Early diagnosis is of [...] ten difficult because of unspecific symptoms. Therapeutic approaches have classically included radical resection, chemotherapy and radiotherapy. Materials and methods: we present our experience in the management of primary colorectal lymphomas over a 17-year period (1994-20011). Results: in this period 7 cases of primary colorectal lymphoma were diagnosed in our institution. Abdominal pain and change in bowel habit were the most frequent symptoms. Five patients underwent emergency surgery because of bleeding or bowel obstruction. All primary intestinal lymphomas studied were of the B-cell phenotype. Patients were followed up for a median of 59 months (range 1-180). Three of them are alive with no evidence of recurrence. Conclusion: combination treatment with chemotherapy and surgery can obtain good remission rate. Surgery can resolve complications such bleeding or intestinal perforation that are implicated in lymphoma mortality.

Marta, Pascual; Blanca, Sánchez-González; Mar, García; Miguel, Pera; Luis, Grande.

80

Intravascular Ultrasound Image Segmentation Using Morphological Snakes  

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Full Text Available From the first use of the technics of intravascular ultrasound (IVUS as an imaging technique for the coronary artery system at the 70th century until now , the segmentation of the arterial wall boundaries still an important problem . Much research has been done to give better segmentation result for better diagnostics , evaluation and therapy planning. In this paper we present a new segmentation technics based on Morphological Snakes which developed by Luis Álvarez used for the first time for IVUS segmentation. It is a simple , fast and stable approach of snakes evolution algorithm. Results are presented and discussed in order to demonstrate the effectiveness of this approach in IVUS segmentation.

Hamdi Mohamed Ali

2012-06-01

 
 
 
 
81

Pulmonary intravascular hemangiosarcoma in a cat  

International Nuclear Information System (INIS)

A 9-year-old, castrated male Japanese domestic cat presented with a complaint of exertional dyspnea. Based on the radiographic findings, presumptive diagnosis of aspiration pneumonia or primary diffuse pulmonary neoplasia in the right middle lobe was made. Histologically, the pulmonary lesion was characterized by diffuse thickening of alveolar wall with the proliferation of apparently atypical irregular-shaped cells. Immunohistochemical staining using anti-human factor VIII-related antigen antiserum showed positive reaction in the cytoplasm of the atypical cells. According to the findings, the lesion was diagnosed as pulmonary intravascular hemangiosarcoma

82

Linfoma de Hodgkin: aspectos atuais Hodgkin lymphoma: current issues  

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Full Text Available A par dos extraordinários avanços obtidos no tratamento do linfoma de Hodgkin, diversos desafios persistem na compreensão da biologia da doença, e na determinação de alternativas que maximizem a eficácia terapêutica e minimizem as toxicidades imediatas e tardias. O objetivo deste artigo é apresentar informações recentes que têm relevância imediata para aqueles que cuidam de pacientes com linfoma de Hodgkin (LH.Knowing the extraordinary advances obtained in the treatment of Hodgkin's lymphoma, several challenges persist related to the biology of the disease and to the determination of alternatives that maximize the therapeutic efficacy and minimize immediate and long-term toxicity. The aim of this article is to present recent information that has immediate relevance for those who care for patients with Hodgkin's lymphoma.

Nelson Spector

2009-08-01

83

Asociación de linfomas malignos con herpes virus I y II  

Scientific Electronic Library Online (English)

Full Text Available SciELO Peru | Language: Spanish Abstract in spanish Objetivos: Conocer la prevalencia de la seropositividad para herpes virus I y II en pacientes con linfomas non Hodgkin y su asociación con el linaje celular (B ó T). Pacientes y métodos: Se tomó una muestra de 60 pacientes en el Hospital Almenara de agosto de 1999 a diciembre del 2000 todos ellos pa [...] cientes con diagnostico establecido de linfoma non Hodgkin nuevos o en primera recaída, el análisis se realizó mediante bioestadística descriptiva. Resultados: La mediana de la edad fue de 59 años, 2/3 fueron varones, 65% pacientes nuevos y el linfoma primario fue extraganglionar en un 58% de los casos. El 80% de los linfomas fueron a células B y mas del 90% en estadios avanzados (III y IV), ningún caso fue positivo para IgM herpes I o II y 25% tuvieron serología positiva IgG para herpes I o II (2/3 positivos para IgG I) de los cuales el 93% fueron a células B. Conclusiones: La prevalencia de seropositividad para herpes virus I y II en pacientes con linfoma non Hodgkin es del 25%, mayormente asociado a células B, además de tener un porcentaje considerable de linfomas a células T (25%) y linfomas extranodales (58%); para evaluar la posibilidad de asociación entre este virus y los linfomas requerimos de un estudio caso-control. Abstract in english Objectives: To know the prevalence of seropositivity for herpes virus I and II in patients with malignant non Hodgkin lymphoma (NHL), and the association with the cell lineage (B or T). Patients and Methods: We considered 60 new or in first recurrence patients with NHL at the Hospital Nacional Guill [...] ermo Almenara from August 1999 to December 2000. We analyzed the data by descriptive biostatistics in Epi-Info program. Results: Median age was 59 years, two thirds were men, 65% were new patients and the primary site was extranodular in 58% of the cases. 80% were NHL to B cells, and more than 90% in advance stage (III and IV), none of them were positive for IgM herpes virus I or II and 25% were positive for IgG I or II (2/3 positive for IgG I) and more than 90% of them were for B cell. Conclusion: The prevalence of seropositivity for herpes I or II in patients with NHL was 25%, usually associated to B cells, on the other hand we have an elevated percentage of T cell NHL (25%) as well as extranodular NHL (58%). We need more studies specially a case-control study to define the association of herpes virus I or II with NHL.

Ashley Efraín, Alarcon-Rozas; Fernando, Salas Sánchez; Karina, Villacres Vela; Julio, Guevara Guevara.

84

Asociación de linfomas malignos con herpes virus I y II  

Scientific Electronic Library Online (English)

Full Text Available SciELO Peru | Language: Spanish Abstract in spanish Objetivos: Conocer la prevalencia de la seropositividad para herpes virus I y II en pacientes con linfomas non Hodgkin y su asociación con el linaje celular (B ó T). Pacientes y métodos: Se tomó una muestra de 60 pacientes en el Hospital Almenara de agosto de 1999 a diciembre del 2000 todos ellos pa [...] cientes con diagnostico establecido de linfoma non Hodgkin nuevos o en primera recaída, el análisis se realizó mediante bioestadística descriptiva. Resultados: La mediana de la edad fue de 59 años, 2/3 fueron varones, 65% pacientes nuevos y el linfoma primario fue extraganglionar en un 58% de los casos. El 80% de los linfomas fueron a células B y mas del 90% en estadios avanzados (III y IV), ningún caso fue positivo para IgM herpes I o II y 25% tuvieron serología positiva IgG para herpes I o II (2/3 positivos para IgG I) de los cuales el 93% fueron a células B. Conclusiones: La prevalencia de seropositividad para herpes virus I y II en pacientes con linfoma non Hodgkin es del 25%, mayormente asociado a células B, además de tener un porcentaje considerable de linfomas a células T (25%) y linfomas extranodales (58%); para evaluar la posibilidad de asociación entre este virus y los linfomas requerimos de un estudio caso-control. Abstract in english Objectives: To know the prevalence of seropositivity for herpes virus I and II in patients with malignant non Hodgkin lymphoma (NHL), and the association with the cell lineage (B or T). Patients and Methods: We considered 60 new or in first recurrence patients with NHL at the Hospital Nacional Guill [...] ermo Almenara from August 1999 to December 2000. We analyzed the data by descriptive biostatistics in Epi-Info program. Results: Median age was 59 years, two thirds were men, 65% were new patients and the primary site was extranodular in 58% of the cases. 80% were NHL to B cells, and more than 90% in advance stage (III and IV), none of them were positive for IgM herpes virus I or II and 25% were positive for IgG I or II (2/3 positive for IgG I) and more than 90% of them were for B cell. Conclusion: The prevalence of seropositivity for herpes I or II in patients with NHL was 25%, usually associated to B cells, on the other hand we have an elevated percentage of T cell NHL (25%) as well as extranodular NHL (58%). We need more studies specially a case-control study to define the association of herpes virus I or II with NHL.

Ashley Efraín, Alarcon-Rozas; Fernando, Salas Sánchez; Karina, Villacres Vela; Julio, Guevara Guevara.

2002-04-01

85

Linfoma de Hodgkin: aspectos atuais / Hodgkin lymphoma: current issues  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese A par dos extraordinários avanços obtidos no tratamento do linfoma de Hodgkin, diversos desafios persistem na compreensão da biologia da doença, e na determinação de alternativas que maximizem a eficácia terapêutica e minimizem as toxicidades imediatas e tardias. O objetivo deste artigo é apresentar [...] informações recentes que têm relevância imediata para aqueles que cuidam de pacientes com linfoma de Hodgkin (LH). Abstract in english Knowing the extraordinary advances obtained in the treatment of Hodgkin's lymphoma, several challenges persist related to the biology of the disease and to the determination of alternatives that maximize the therapeutic efficacy and minimize immediate and long-term toxicity. The aim of this article [...] is to present recent information that has immediate relevance for those who care for patients with Hodgkin's lymphoma.

Nelson, Spector.

86

Disseminated Intravascular Coagulation and Death Due to Snake Bites  

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Full Text Available Disseminated intravascular coagulation is a serious and life threatening systemic complication of snake bites that can cause death if the treatment is delayed. Herein we present a 57-year-old female patient with no prior systemic disease who died because of disseminated intravascular coagulation that developed in 6 hours due to a snake bite.

Yavuz Orak

2012-04-01

87

Contribuição da medicina nuclear para a avaliação dos linfomas  

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A medicina nuclear permite a caracterização funcional de tecidos, acrescentando dados à avaliação anatômica realizada por outros métodos de imagem, como a tomografia computadorizada, ressonância magnética ou ultra-som. Além do diagnóstico e estadiamento, as informações funcionais fornecidas pela medicina nuclear são particularmente úteis no seguimento e avaliação de resposta terapêutica dos pacientes com linfoma. A presença de massa residual após quimioterapia ou a infiltr...

Sapienza Marcelo T.; Marone Marília M. S.; Chiattone Carlos S

2001-01-01

88

Linfoma de Burkitt en un portador de granulomatosis de Wegener  

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Full Text Available Se reporta el caso de un paciente costarricense portador de granulomatosis de Wegener, en tratamiento con ciclofosfamida y prednisona, quien desarrolla un linfoma de Burkitt que lo lleva a la muerte. Se menciona la posible relación entre estas dos patologías.This is a report of a costarrican male with Wegener' s granulomatosis undergoing treatment with prednisone and cyclophosphamide, he developed a fatal Burkitt' s lymphoma. The possible relationship between these two disorders is addressed.

Kryssia Rodríguez-Castro

2005-10-01

89

Role of informed consent for intravascular contrast media  

International Nuclear Information System (INIS)

To evaluate the usefulness of different degrees of informed consent for intravascular contrast media, the authors divided 100 patients into four groups: (1) informed consent with no information on intravascular contrast media, (2) simple written informed consent that detailed common risks, (3) detailed written informed consent that detailed all known risks, and (4) MD informed consent, during which a radiologist discussed all known risks of intravascular contrast media. Physician counseling time for group 4 averaged 11.4 minutes. On a postprocedure test about the common complications and risk factors of intravascular contrast media, the average scores were: group 1, 38.4%; group 2, 68.2%; group 3, 63.2%; and group 4, 69.8%. There was no statistical difference between groups 2-4 on the postprocedure test. If informed consent is to be used prior to intravascular contrast media administration, a simple written consent detailing the common risks and risk factors appears to be the best method

90

Acantosis nigricans y linfoma no Hodgkin: presentación de un caso  

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Full Text Available Fundamento: la acantosis nigricans fue la primera dermatosis en la que se reconoció un carácter paraneoplásico. La característica sobresaliente es la hiperpigmentación simétrica y el engrosamiento aterciopelado de la piel. Se sugiere que algún factor producido por el tumor estimula el crecimiento epidérmico. Objetivo: presentar un caso poco frecuente de un paciente con el diagnóstico de linfoma no Hodgkin y acantosis nigricans. Caso clínico: se presenta el caso de un paciente masculino de 62 años de edad con antecedentes de hipertensión arterial que un año previo a su ingreso manifestó cambios en la coloración de la piel, dermatosis generalizada, hiperpigmentación e hiperqueratosis en las palmas de las manos y el cuello. Conclusiones: el tumor más frecuente asociado con acantosis es el adenocarcinoma abdominal en 90 % de los casos, entre los cuales 64 a 69 % son de origen gástrico; el resto (10 % se asocian con cáncer no digestivo; linfoma de Hodgkin, micosis fungoide, cáncer de esófago, próstata y tiroides. En el linfoma no Hodgkin su asociación es considerada muy rara y son pocos los casos reportados en la bibliografía.

Miguel Dami\\u00E1n Junco Bonet

2014-01-01

91

Actualidad clínica-biológica de los linfomas T cutáneos  

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Full Text Available Los linfomas cutáneos resultan modelos útiles para el estudio de los mecanismos patogénicos de las enfermedades linfoproliferativas dado que para el diagnóstico y el seguimiento, las muestras de tejido se obtienen a través de métodos no invasivos. Aunque los linfomas T cutáneos se desarrollan a partir de los linfocitos T residentes en la piel, otras células y diversos factores asociados al tejido linfoide participan en la linfomagénesis. La aparición de estos linfomas en la piel no excluye la presencia de células malignas en la circulación y su desarrollo en otros órganos. Actualmente, la posibilidad de detectar las lesiones en estadios tempranos y la precisión de alteraciones en el receptor de células T permite ampliar el estudio de esta enfermedad.The cutaneous lymphomas are useful models for studying the etiopathogenic mechanisms of the lymphoproliferative diseases, since the samples of tissue are obtained through non invasive methods for the diagnosis and follow-up. Although the cutaneous T-cell lymphomas are developed from the T lymphocytes existing in the skin, other cells and diverse factors associated with the lymphoid tissues take part in the lymphomagenesis. The appearance of these lymphomas in the skin does not exclude the presence of malignant cells in the circulation and their development in other organs. Nowadays, the possibility of detecting the injuries in early stages and the accuracy of alterations in the T-cell receptor allows to extend the study of this disease.

María E. Faxas García

2003-03-01

92

Aneurismas saculares: avaliação experimental de procedimento terapeutico por via intravascular / Saccular aneurysms: experimental evaluation of the efficacy of an intra-vascular therapeutic procedure  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Visando à avaliar a possibilidade de ocluir aneurismas saculares através da injeção intra-vascular por cateterismo super-seletivo de um adesivo tecidual, os autores injetaram Bucrylat (isobutil-2-cianoacrilato) no interior de quatorze aneurismas produzidos artificialmente em artérias carótidas de cã [...] es. Estudos angiográficos realizados imediatamente antes e depois da injeção e 1 mês após o tratamento revelaram uma oclusão progressiva e persistente dos aneurismas. Os exemplares examinados histologicamente 1 mês após a injeção demonstraram a presença de uma faixa fibrosa endotelializada cruzando o colo do aneurisma, o que parece indicar o caráter permanente da oclusão dos aneurismas tratados. Em nosso estudo, a reação tecidual ao adesivo foi discreta e restrita à íntima das artérias. A aplicação clínica deste método dependerá dos avanços nas técnicas de cateterização intracraniana super-seletiva, que irão permitir um cateterismo preciso e seguro da câmara aneurismática. Abstract in english Studies were performed on adult mongrel dogs to evaluate the possibility of occluding saccular aneurysms with an intravascular injection of the tissue adhesive Bucrylat (isobutyl-2-cyanoacrylate). Fourteen surgically constructed carotid aneurysms were occluded by the injection of Bucrylat through a [...] fluoroscopically positioned intra-arterial catheter. Angiography performed immediately before and after injection and up to 1 month following treatment revealed progressive and persistent occlusion of the aneurysms. The specimens examined histologically 1 month after the injection showed an endothelialized fibrous tissue bridge crossing the neck of the aneurysm what appear to indicate a permanent occlusion of the structures treated. A similar approach to treat intracranial aneurysms will depend on advances in the field of selective intracranial catheterization that will permit safe and accurate catheterization of the aneurysm sac.

Mario G., Siqueira; Ivoney A., Vieira; Elizeu A., Cilião; Dora M. G., Guerra.

93

Aneurismas saculares: avaliação experimental de procedimento terapeutico por via intravascular Saccular aneurysms: experimental evaluation of the efficacy of an intra-vascular therapeutic procedure  

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Full Text Available Visando à avaliar a possibilidade de ocluir aneurismas saculares através da injeção intra-vascular por cateterismo super-seletivo de um adesivo tecidual, os autores injetaram Bucrylat (isobutil-2-cianoacrilato no interior de quatorze aneurismas produzidos artificialmente em artérias carótidas de cães. Estudos angiográficos realizados imediatamente antes e depois da injeção e 1 mês após o tratamento revelaram uma oclusão progressiva e persistente dos aneurismas. Os exemplares examinados histologicamente 1 mês após a injeção demonstraram a presença de uma faixa fibrosa endotelializada cruzando o colo do aneurisma, o que parece indicar o caráter permanente da oclusão dos aneurismas tratados. Em nosso estudo, a reação tecidual ao adesivo foi discreta e restrita à íntima das artérias. A aplicação clínica deste método dependerá dos avanços nas técnicas de cateterização intracraniana super-seletiva, que irão permitir um cateterismo preciso e seguro da câmara aneurismática.Studies were performed on adult mongrel dogs to evaluate the possibility of occluding saccular aneurysms with an intravascular injection of the tissue adhesive Bucrylat (isobutyl-2-cyanoacrylate. Fourteen surgically constructed carotid aneurysms were occluded by the injection of Bucrylat through a fluoroscopically positioned intra-arterial catheter. Angiography performed immediately before and after injection and up to 1 month following treatment revealed progressive and persistent occlusion of the aneurysms. The specimens examined histologically 1 month after the injection showed an endothelialized fibrous tissue bridge crossing the neck of the aneurysm what appear to indicate a permanent occlusion of the structures treated. A similar approach to treat intracranial aneurysms will depend on advances in the field of selective intracranial catheterization that will permit safe and accurate catheterization of the aneurysm sac.

Mario G. Siqueira

1980-03-01

94

Wilms' tumor with intravascular extension: A review article.  

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Intravascular extension of Wilms' tumor is a well-recognized phenomenon. Intravascular extension into the vena cava occurs in only 4-8% of patients with Wilms' tumors and intraatrial extension occurs in around 1-3% of patients. This review of the published literature in this cohort aims to summarize the findings of different case series to provide an optimum management plan. A literature search was performed and index papers were retrieved for review. The search included the following terms: Intracaval, intravascular, intraatrial and intracardiac extension of Wilms' tumor or nephroblastoma. The management of patients with intravascular tumor thrombus in Wilms' tumor is complex. A skilled multi-disciplinary team at a tertiary referral center with cardiothoracic surgery available should manage these patients. Multi-modal diagnostic and preoperative imaging are required to confirm and define the extent of the extension. Preoperative chemotherapy is advocated for all but exceptional circumstances and must be followed closely. Surgical resection should be planned according to the stage of intravascular extension with possible need for cardiopulmonary bypass and deep hypothermia with cardiac arrest if required. Surgical complications are more common in this group of patients, but outcome is comparable to those without intravascular extension, and is more closely correlated with the histological subtype then stage of intravascular extension. Operative imaging are required to confirm and define the extent of the extension. PMID:25336800

McMahon, Suzanne; Carachi, Robert

2014-10-01

95

Síndrome de vena cava superior: Una emergencia oncológica en niños con linfoma. Revisión de 5 casos Superior Vena Cava Syndrome: an oncologic emergency in children with lymphoma  

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Full Text Available Introducción: Un niño con cáncer puede presentar durante su enfermedad una emergencia, ya sea como manifestación inicial, en la fase de diagnóstico, durante la evolución o en el periodo terminal. Objetivo: Presentar nuestra experiencia en el manejo del síndrome de Vena Cava Superior en niños con linfoma. Pacientes y Método: Revisión retrospectiva de 44 fichas clínicas de menores de 15 años con linfoma tratados entre enero de 1989 y diciembre de 1999 en la Unidad de Hematología/Oncología Infantil del Hospital Clínico Regional de Valdivia. Resultados: 5 casos presentaron síndrome de Vena Cava Superior: Linfoma de Hodgkin 2. Linfoma no Hodgkin 3. El síndrome de Vena Cava Superior fue la manifestación inicial en 4. En la emergencia todos los pacientes recibieron corticoides y radioterapia. Tres pacientes se encuentran vivos y en remisión completa. Conclusiones: El síndrome de Vena Cava Superior, es poco frecuente en niños con patología tumoral, sin embargo, por constituir una emergencia médica requiere tratamiento inmediato, necesitándose claras pautas de manejoIntroduction: A child with cancer may have an oncologic emergency during one of the following situations: A Primary manifestation of the disease. B Diagnostic phase. C During clinical evolution of the disease. D Terminal stage. Objective: To review our experience in the management of patients with lymphoma presenting with Superior Vena Cava Syndrome (SVCS. Method: Retrospective analysis of clinical data of 44 patients younger than 15 years-old affected with lymphoma and treated at the Hemathology/Oncology Unit of the Clinical Hospital from Valdivia, between 1989 and 1999. Results: 5 patients presented SVCS; 2 of them had Hodgkin lymphoma and 3 had no-Hodgkin lymphoma. The SVCS was the first clinical manifestation in 4 of them. During the emergency, all patients were treated with steroids and radiotherapy, observing 3 of them still alive and free of disease. Conclusions: The SVCS is a rare complication in pediatric tumoral disease. It constitutes an oncologic emergency that we ought to know in terms of diagnosis and treatment

Miriam Davis G.

2005-10-01

96

Placental intravascular organisms: a case report.  

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Ascending amniotic fluid bacterial infection is a cause of perinatal morbidity and mortality. A diagnosis of amniotic cavity infection can be inferred by documenting maternal (acute chorioamnionitis) and/or fetal (chorionic plate vasculitis; umbilical vasculitis/funisitis) inflammatory response. A definitive diagnosis of intrauterine/neonatal sepsis as a cause of stillbirth requires positive blood cultures obtained at postmortem examination. However, if postmortem examination is not performed, acute chorioamnionitis with/without fetal inflammatory response cannot be classified as a cause of demise. We present a case of intrauterine demise associated with acute chorioamnionitis, villitis, and intervillositis of the placenta. Although postmortem examination was denied, a conclusive diagnosis of intrauterine sepsis could be rendered by demonstration of gram-positive cocci within fetal vessels of umbilical cord, chorionic plate, and stem villi. This report highlights the importance of identification of placental intravascular organisms as unequivocal evidence of fetal sepsis, especially in cases where cultures cannot be obtained. PMID:20877362

Matoso, A; Shapiro, S; De Paepe, M E; Gundogan, F

2010-10-01

97

Ventricular metastasis resulting in disseminated intravascular coagulation  

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Background Disseminated Intravascular Coagulation (DIC) complicates up to 7% of malignancies, the commonest solid organ association being adenocarcinoma. Transitional Cell Carcinoma (TCC) has rarely been associated with DIC. Case presentation A 74-year-old woman with TCC bladder and DIC was found to have a cardiac lesion suspicious for metastatic disease. The DIC improved with infusion of plasma and administration of Vitamin K, however the cardiac lesion was deemed inoperable and chemotherapy inappropriate; given the patients functional status. We postulate that direct activation of the coagulation cascade by the intraventricular metastasis probably triggered the coagulopathy in this patient. Conclusion Cardiac metastases should be considered in cancer patients with otherwise unexplained DIC. This may influence treatment choices. PMID:15913454

John, Thomas; Davis, Ian D

2005-01-01

98

[Angiotropic lymphoma (intravascular lymphomatosis)--2 case reports].  

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Described are two cases of angiotropic lymphoma where eventually autopsy elucidated nonspecific neurologic symptoms. One patient suffering ambiguous encephalitic syndrome died three months later, the second one passed away after an unusually long three-year period of progressive dementia and cumulative motoric dysfunction. The autopsy disclosed pure intravascular malignant lymphoid aggregates (LCA, CD 20, Bcl 2-positive) in the brain and kidney of both patients. In the patients with the longer disease period, a dissemination to lung was also found. Definitive diagnosis was issued as a B cell type of angiotropic lymphoma. Skin, lymph nodes, spleen, and bone marrow were not affected in any case. The clinical differential diagnosis algorithm did not involve this rare etiology in these particular uncommon neurologic cases and even brain biopsy performed in both women did not recognize the substantiality of the disease. PMID:12673939

Kinkor, Z; Svitáková, I; Hadravská, S; Hejda, V; Mat?jovic, M

2003-01-01

99

Ventricular metastasis resulting in disseminated intravascular coagulation  

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Full Text Available Abstract Background Disseminated Intravascular Coagulation (DIC complicates up to 7% of malignancies, the commonest solid organ association being adenocarcinoma. Transitional Cell Carcinoma (TCC has rarely been associated with DIC. Case presentation A 74-year-old woman with TCC bladder and DIC was found to have a cardiac lesion suspicious for metastatic disease. The DIC improved with infusion of plasma and administration of Vitamin K, however the cardiac lesion was deemed inoperable and chemotherapy inappropriate; given the patients functional status. We postulate that direct activation of the coagulation cascade by the intraventricular metastasis probably triggered the coagulopathy in this patient. Conclusion Cardiac metastases should be considered in cancer patients with otherwise unexplained DIC. This may influence treatment choices.

Davis Ian D

2005-05-01

100

Death following intravascular administration of contrast media  

International Nuclear Information System (INIS)

Adverse reactions to intravascularly administered contrast media preceding death and the autopsy findings in 44 patients are presented. There is a wide scatter of the age distribution of fatal reactions. The highest incidence is in the 50-70 year age group. Similar observations were obtained from the 405 deaths due to contrast media reported to the Food and Drug Administration of the United States. In the same age group the number of reactions is highest, likewise the autopsy findings. The predominant autopsy findings are pulmonary edema, congestion and hemorrhage; arteriosclerosis, both general and coronary. In the younger age group the autopsy findings are limited mostly to the respiratory tract. Fatal reactions to contrast media occur often without warning and most deaths occur within 15 min to 6 hours. Reactions to contrast media occur without relation to sex or age. (orig.)

 
 
 
 
101

Intravascular embolization treatment of cerebral arteriovenous malformations  

International Nuclear Information System (INIS)

Objective: To find out the method and effects of intravascular treatment of cerebral arteriovenous malformations (AVM). Methods: A group of 82 patients were analysed. 20 cases of the group with symptom of epilepsy, 51 with intra-cranial haemorrhage, 18 with complaint of headache, and 8 with other symptoms. Based on the locations of the lesions, lesions of 66 cases located in cerebral hemisphere, 6 in basal ganglia area, 7 in cerebella, and 3 in brain stem. Based on the size of malformations, 23 cases were classified as huge type, 50 as medium type and 9 as the small type. Embolization materials NBCA were used in 64 cases IBCA in 12 cases, surgical threads in 4 cases and silk surgical threads with IBCA in 2 cases. Results: 27 cases of the group were anatomically cured, 15 caes showed 80% shrinkage of the malformations in size, 28 cases with 50%-80% shrinkage, 12 cases less than 50% shrinkage and 5 patients with resection of malformations after the embolization. 52 cases of the group were totally recovered to normal life, 20 cases with marked improvement of symptoms and signs, 8 cases with no remarkable improvement of signs and 2 cases were aggravated, but without any mortality. Complications of spasm occurred in 7 patients, cerebral over-infusion in 3 patients, broken of catheter in 3 and mal-embolization in one. Conclusions: Intravascular interventional embolization is a safe and effective method for treating AVMs, with complete cure in some patients anatomically. It could be a method of first choice in treating some operationally difficult cases

102

Leucemia / linfoma T del adulto: Primer caso en Cuba  

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Full Text Available Se presentó el caso de una paciente con diagnóstico de linfoma no Hodgkin de histología agresiva, en el año 1990, que por los hallazgos clínicos y resultados de los exámenes complementarios realizados se sospechó la posibilidad de una leucemia / linfoma tipo T del adulto (LLTA relacionada con la infección por el virus linfotrópico de células T humanas tipo I (conocido como HTLV-I, lo cual fue confirmado por los resultados de los estudios virológicos. Se observó comportamiento evolutivo y respuesta terapéutica tórpidos. Falleció en los primeros 4 meses de efectuado el diagnóstico, lo que corroboró lo publicado en la literatura médica sobre este tema. Este es el primer caso diagnosticado en Cuba de una leucemia / linfoma tipo T del adulto (LLTA relacionada con la infección por el virus linfotrópico de células T humanas tipo I (HTLV-IThe case of a female patient with diagnosis of non Hodgkin lymphoma of aggressive histology in 1990 was presented .According to the clinical findings and to the results of the complementary tests made, it was suspected the possibility of adult T-cell leukemia/lymphoma (ATLL related to human T lymphotropic virus type I (HTLV-1 infection, which was confirmed by the results of the virological studies. It was observed a torpid evolutive behavior and therapeutic response. The patient died during the first 4 months of the diagnosis, which corroborated what is published in medical literature on this topic.This is the first case diagnosed in Cuba of an adult T-cell leukemia/lymphoma associated with HTLV-1.

Jorge E. Muñío Perurena

2003-06-01

103

Leucemia / linfoma T del adulto: Primer caso en Cuba  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Se presentó el caso de una paciente con diagnóstico de linfoma no Hodgkin de histología agresiva, en el año 1990, que por los hallazgos clínicos y resultados de los exámenes complementarios realizados se sospechó la posibilidad de una leucemia / linfoma tipo T del adulto (LLTA) relacionada con la in [...] fección por el virus linfotrópico de células T humanas tipo I (conocido como HTLV-I), lo cual fue confirmado por los resultados de los estudios virológicos. Se observó comportamiento evolutivo y respuesta terapéutica tórpidos. Falleció en los primeros 4 meses de efectuado el diagnóstico, lo que corroboró lo publicado en la literatura médica sobre este tema. Este es el primer caso diagnosticado en Cuba de una leucemia / linfoma tipo T del adulto (LLTA) relacionada con la infección por el virus linfotrópico de células T humanas tipo I (HTLV-I) Abstract in english The case of a female patient with diagnosis of non Hodgkin lymphoma of aggressive histology in 1990 was presented .According to the clinical findings and to the results of the complementary tests made, it was suspected the possibility of adult T-cell leukemia/lymphoma (ATLL) related to human T lymph [...] otropic virus type I (HTLV-1) infection, which was confirmed by the results of the virological studies. It was observed a torpid evolutive behavior and therapeutic response. The patient died during the first 4 months of the diagnosis, which corroborated what is published in medical literature on this topic.This is the first case diagnosed in Cuba of an adult T-cell leukemia/lymphoma associated with HTLV-1.

Jorge E., Muñío Perurena; Héctor M., Díaz Torres; José, Carnot Uria; Raúl, de Castro Arenas; Leonor, Navea Leyva; Inocente, Rodríguez Reyes.

104

Recurrent disseminated intravascular coagulation caused by intermittent dosing of rifampin.  

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Daily rifampin therapy is associated with minimal adverse effects, but administration on an intermittent or interrupted basis has been associated with severe immunoallergic reactions such as hemolytic anemia, acute renal failure, and disseminated intravascular coagulation. We describe a patient with Mycobacterium leprae infection who experienced recurrent episodes of disseminated intravascular coagulation after intermittent exposures to rifampin, and review eight previously reported cases of rifampin-associated disseminated intravascular coagulation. In six (75%) cases, previous exposure to rifampin was reported and seven (87.5%) patients were receiving the medication on an intermittent or interrupted basis. Clinical features of rifampin-associated disseminated intravascular coagulation included fever, hypotension, abdominal pain, and vomiting within hours of ingestion. Average time to reaction was 3-6 doses if rifampin was being administered on a monthly schedule. Three (37.5%) of eight reported cases were fatal. A complete history of previous exposure to rifampin is recommended before intermittent therapy with this medication. PMID:22302861

Havey, Thomas C; Cserti-Gazdewich, Christine; Sholzberg, Michelle; Keystone, Jay S; Gold, Wayne L

2012-02-01

105

21 CFR 880.5210 - Intravascular catheter securement device.  

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...ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL HOSPITAL AND PERSONAL USE DEVICES General...intravascular catheter securement device is a device with an adhesive backing that is placed over a needle or catheter and is...

2010-04-01

106

Apresentação cutânea inicial de linfomas na infância Initial cutaneous manifestation of lymphomas in children  

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Full Text Available Os linfomas cutâneos compreendem um grupo heterogêneo de desordens linfoproliferativas que envolvem a pele e são classificados como um subgrupo dos linfomas não Hodgkin. No período de 1981 a 2007, 100 casos de linfomas em crianças foram admitidos no Serviço de Hematologia, do Hospital das Clínicas da Universidade Federal de Minas Gerais, sendo que nove apresentaram manifestação cutânea inicial. Três pacientes foram classificados como linfoma cutâneo primário e seis como sistêmicos. Sete pacientes apresentaram linfoma de células T, um, linfoma linfoblástico B e um, imunofenótipo indefinido. Nenhum óbito ocorreu nos pacientes com linfoma cutâneo primárioCutaneous lymphomas comprise a heterogeneous group of lymphoproliferative disorders with skin involvement and are classified as a subgroup of non-Hodgkin lymphomas. From 1981 to 2007, 100 children with non-Hodgkin lymphomas were admitted to the Hematology Unit of the Federal University of Minas Gerais Teaching Hospital. In nine of these children, the skin was involved at the onset of the disease. Three patients were classified as having primary cutaneous lymphoma, while in six the disease was systemic with cutaneous involvement. In seven patients, the immunophenotype was T-cell, in one it was B-cell, and in the remaining case the immunophenotype was indefinable. No deaths occurred in any of the children with primary cutaneous lymphoma

Maria Christina Lopes Araujo de Oliveira

2011-08-01

107

Apresentação cutânea inicial de linfomas na infância / Initial cutaneous manifestation of lymphomas in children  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Os linfomas cutâneos compreendem um grupo heterogêneo de desordens linfoproliferativas que envolvem a pele e são classificados como um subgrupo dos linfomas não Hodgkin. No período de 1981 a 2007, 100 casos de linfomas em crianças foram admitidos no Serviço de Hematologia, do Hospital das Clínicas d [...] a Universidade Federal de Minas Gerais, sendo que nove apresentaram manifestação cutânea inicial. Três pacientes foram classificados como linfoma cutâneo primário e seis como sistêmicos. Sete pacientes apresentaram linfoma de células T, um, linfoma linfoblástico B e um, imunofenótipo indefinido. Nenhum óbito ocorreu nos pacientes com linfoma cutâneo primário Abstract in english Cutaneous lymphomas comprise a heterogeneous group of lymphoproliferative disorders with skin involvement and are classified as a subgroup of non-Hodgkin lymphomas. From 1981 to 2007, 100 children with non-Hodgkin lymphomas were admitted to the Hematology Unit of the Federal University of Minas Gera [...] is Teaching Hospital. In nine of these children, the skin was involved at the onset of the disease. Three patients were classified as having primary cutaneous lymphoma, while in six the disease was systemic with cutaneous involvement. In seven patients, the immunophenotype was T-cell, in one it was B-cell, and in the remaining case the immunophenotype was indefinable. No deaths occurred in any of the children with primary cutaneous lymphoma

Maria Christina Lopes Araujo de, Oliveira; Luciana Baptista, Pereira; Priscila Cezarino, Rodrigues; Keyla Cunha, Sampaio; Benigna Maria de, Oliveira; Marcos Borato, Viana.

108

Linfoma de Burkitt en un portador de granulomatosis de Wegener  

Scientific Electronic Library Online (English)

Full Text Available SciELO Costa Rica | Language: Spanish Abstract in spanish Se reporta el caso de un paciente costarricense portador de granulomatosis de Wegener, en tratamiento con ciclofosfamida y prednisona, quien desarrolla un linfoma de Burkitt que lo lleva a la muerte. Se menciona la posible relación entre estas dos patologías. [...] Abstract in english This is a report of a costarrican male with Wegener' s granulomatosis undergoing treatment with prednisone and cyclophosphamide, he developed a fatal Burkitt' s lymphoma. The possible relationship between these two disorders is addressed. [...

Kryssia, Rodríguez-Castro; Henry, Zamora-Barquero.

109

Intravascular Brachytherapy. A model for the calculation of the dose.  

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In this study we present the radiation dose distribution for a theoretical model with Montecarlo simulation, and based on an experimental model developed for the study of the prevention of restenosis post-angioplasty employing intravascular brachytherapy. In the experimental in vivo model, the atherosclerotic plaques were induced in femoral arteries of male New Zealand rabbits through surgical intervention and later administration of cholesterol enriched diet. For the intravascular irradiatio...

Pirchio, Rosana; Marti?n, Gabriela; Rivera, Elena; Cricco, Graciela; Cocca, Claudia; Gutie?rrez, Alicia; Nu?n?ez, Mariel; Bergoc, Rosa; Guzma?n, Luis; Belardi, Diego

2002-01-01

110

Unrecognized stenosis by angiography documented by intravascular ultrasound imaging.  

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This report documents how intravascular ultrasound imaging was used to diagnose a short "napkin-ring" stenosis that was missed by coronary angiography. Intravascular ultrasound revealed a lumen of 2.6 x 2.5 mm in diameter and 5.0 mm2 in cross-sectional area, with a residual atheroma that occluded 63% of available cross-sectional area at the stenosis. PMID:1868534

Ehrlich, S; Honye, J; Mahon, D; Bernstein, R; Tobis, J

1991-07-01

111

UV-Irradiation affects antioxidants in the intravascular compartment  

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UV-IRRADIATION AFFECTS ANTIOXIDANTS IN THE INTRAVASCULAR COMPARTMENT. Roeckl, T., Hutler, M., Beneke, R., Boning, D., Krause, R., Buehring, M. Depts of Sports Medicine and Natural Medicine, Univ. Hosp. Benjamin Franklin, Free University Berlin, Germany. UV-radiation can provoke oxidative stress in human skin. The possible involvement of the intravascular compartment was investigated. 16 subjects (sex; 7f, 9m; age 47 + 13; bmi 27 + 3.6) were irradiated increasingly for a period of 6 weeks, ...

Roeckl, Tobias

2010-01-01

112

Pain in an osseous lymphoma. A case presentation. Dolor en el linfoma oseo. Presentación de un caso.  

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Full Text Available This is a 79 year-old, white, male patient suffering from osseous lymphoma, a less frequent illness, came to the university Hospital Dr. Gustavo Aldereguía Lima¨ in Cienfuegos city, Cuba complaining of intercostal pain in the left hemithorax. This pain was not relieved with the regular medical treatment, that´s why the anesthesia service doctors gave assistance. Costal osteolysis at level D7, D8 and D9 were shown in a thorax X ray. He was treated with analgesic through peridural via such as morphine, local anesthetic. Betametasone was used as anti-inflammatory having positive results. The use of ethylic alcohol as agents contributed to the patient´s improvement and to get back to his normal life. 

Se presenta el caso de un paciente del hospital provincial clínico quirúrgico universitario ¨Dr. Gustavo Aldereguía Lima¨ de Cienfuegos, portador de una enfermedad muy poco frecuente (linfoma óseo, de 79 años de edad, masculino, de raza blanca, que refería dolor intercostal en hemitórax izquierdo, el cual no cedía ante el tratamiento médico habitual, por lo que es atendido por anestesiología. En el rayos X de tórax se apreció osteolisis costal a nivel de D7, D8 y D9. En forma frecuente fue tratado con analgésicos por vía peridural: morfina, anestésicos locales y como antiinflamatorio la betametasona con resultados satisfactorios. El uso de agentes como el alcohol etílico, contribuyó a mejorar su cuadro y a que se incorporara a sus labores habituales.

Alexis Guillén Sánchez

2003-05-01

113

Diffuse large B-cell lymphoma of the oral cavity / Linfoma difuso de células B grandes de la cavidad bucal  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: English Abstract in spanish Se reporta un caso de linfoma difuso de células B grandes (DLBL) de la cavidad bucal. Se trata de un paciente masculino, blanco, de 73 años de edad, que se presentó a la División de Estomatología, con una masa nodular difusa en el paladar duro y una lesión nodular en el labio superior, diagnosticada [...] s como DLBL. El paciente fue tratado con ocho ciclos de quimioterapia CHOP (ciclofosfamida, doxorrubicina, vincristina, prednisona), pero se constató recidiva de la enfermedad en ambos sitios primarios, en el paladar duro y en el labio superior a los 22 meses después del término de la terapia. El paciente fue sometido de nuevo a la quimioterapia. Abstract in english The authors report a case of diffuse large B-cell lymphoma (DLBL) of the oral cavity. The patient was a 73-year-old white man who first presented at the Division of Stomatology with a large nodular mass in the hard palate and a nodular lesion in the upper lip, which were diagnosed as DLBL. The patie [...] nt was treated with eight cycles of CHOP chemotherapy (cyclophosphamide, doxorubicin, vincristine and prednisone), but the disease recurred 22 months after the end of the therapy. Both primary sites hard palate and upper lip were involved again and the patient was resubmitted to chemotherapy.

Marcelo, Carlos Bortoluzzi; Jonas, Dantas Batista; Karen, Cherubini; Fernanda, Gonçalves Salum; Maria Antonia, Figueiredo.

114

Diffuse large B-cell lymphoma of the oral cavity Linfoma difuso de células B grandes de la cavidad bucal  

Directory of Open Access Journals (Sweden)

Full Text Available The authors report a case of diffuse large B-cell lymphoma (DLBL of the oral cavity. The patient was a 73-year-old white man who first presented at the Division of Stomatology with a large nodular mass in the hard palate and a nodular lesion in the upper lip, which were diagnosed as DLBL. The patient was treated with eight cycles of CHOP chemotherapy (cyclophosphamide, doxorubicin, vincristine and prednisone, but the disease recurred 22 months after the end of the therapy. Both primary sites hard palate and upper lip were involved again and the patient was resubmitted to chemotherapy.Se reporta un caso de linfoma difuso de células B grandes (DLBL de la cavidad bucal. Se trata de un paciente masculino, blanco, de 73 años de edad, que se presentó a la División de Estomatología, con una masa nodular difusa en el paladar duro y una lesión nodular en el labio superior, diagnosticadas como DLBL. El paciente fue tratado con ocho ciclos de quimioterapia CHOP (ciclofosfamida, doxorrubicina, vincristina, prednisona, pero se constató recidiva de la enfermedad en ambos sitios primarios, en el paladar duro y en el labio superior a los 22 meses después del término de la terapia. El paciente fue sometido de nuevo a la quimioterapia.

Marcelo Carlos Bortoluzzi

2010-09-01

115

Diagnóstico de Linfoma no Hodgkin con infiltración intra-auricular / No Hodgkin Linfoma diagnosis with intra-atrial infiltration  

Scientific Electronic Library Online (English)

Full Text Available SciELO Venezuela | Language: Spanish Abstract in spanish Los tumores cardíacos, son entidades raras en la práctica médica, tienen una incidencia del 0,05%, aproximadamente el 75% es benigno y un 25% maligno. De estos el linfoma es infrecuente representando alrededor del 0,25%. Los linfomas no Hodgkin pueden ser extranodales en el 20% de los casos, así mis [...] mo el 80% de los linfomas no Hodgkin son de células B difusos, que es la forma más frecuente de presentación en adultos jóvenes; corresponden a alto grado de malignidad y crecimiento rápido, pueden presentarse con infiltración primaria a diferentes órganos, con afectación cardiaca en 20 a 28% de los casos y suelen localizarse en las cavidades derechas. Los síntomas son inespecíficos, dependientes de la localización y extensión del tumor y la prueba diagnóstica en estos casos es indudablemente la biopsia ya sea del ganglio linfático o del tejido afectado. Se presenta un caso de linfoma no Hodgkin difuso, de células grandes con afectación intra-auricular derecha, en una paciente de 23 años que debutó con disnea progresiva. Se realizó un ecocardiograma transesofágico que detectó una masa tumoral intra-auricular derecha, por lo que se realizó biopsia por cateterismo venoso por vía femoral, que permitió hacer el diagnóstico histopatológico y establecer el tratamiento, con lo cual se encuentra en primera remisión completa a un año del evento Abstract in english Cardiac tumors are rare entities in clinical practice, with an incidence of 0.05%. Approximately 75% are benign and 25% malignant. Among these, Lymphomas are uncommon, representing about 0.25%. The non-Hodgkin lymphomas can occur in extranodal tissues in 20% of the cases and 80% of these non-Hodgkin [...] lymphomas are composed of diffuse B cells. The extranodal presentation is most frequent in young adults, with a high degree of malignancy and rapid growth. It can present with primary infiltration of various organs; cardiac involvement occurs in 20 to 28% of cases, usually located in the right chambers and with nonspecific symptoms, depending on the location and extent of the tumor. The diagnostic test in these cases is undoubtedly the biopsy of the lymph node or the affected tissue. We present the case of non-Hodgkin disease of diffuse large cells, with right intra-atrial involvement in a 23-year-old-female patient, who presented with progressive dyspnea. A transesophageal echocardiography was performed and an intra-atrial tumor mass was detected. A biopsy was performed, by femoral venous catheterization, allowing the establishment of the histopathological diagnosis and treatment. At a one year follow up, the patient shows complete remission

Marco Antonio, Alcocer Gamba; Salvador León, González; Eliodoro, Castro Montes; Luis Martín, Loarca Piña; Leslie Marisol, Lugo Gavidia; Enrique, García Hernández; Ulises, González Galindo; Miguel Isaías, Paredes Serrano.

116

Diagnóstico de Linfoma no Hodgkin con infiltración intra-auricular / No Hodgkin Linfoma diagnosis with intra-atrial infiltration  

Scientific Electronic Library Online (English)

Full Text Available SciELO Venezuela | Language: Spanish Abstract in spanish Los tumores cardíacos, son entidades raras en la práctica médica, tienen una incidencia del 0,05%, aproximadamente el 75% es benigno y un 25% maligno. De estos el linfoma es infrecuente representando alrededor del 0,25%. Los linfomas no Hodgkin pueden ser extranodales en el 20% de los casos, así mis [...] mo el 80% de los linfomas no Hodgkin son de células B difusos, que es la forma más frecuente de presentación en adultos jóvenes; corresponden a alto grado de malignidad y crecimiento rápido, pueden presentarse con infiltración primaria a diferentes órganos, con afectación cardiaca en 20 a 28% de los casos y suelen localizarse en las cavidades derechas. Los síntomas son inespecíficos, dependientes de la localización y extensión del tumor y la prueba diagnóstica en estos casos es indudablemente la biopsia ya sea del ganglio linfático o del tejido afectado. Se presenta un caso de linfoma no Hodgkin difuso, de células grandes con afectación intra-auricular derecha, en una paciente de 23 años que debutó con disnea progresiva. Se realizó un ecocardiograma transesofágico que detectó una masa tumoral intra-auricular derecha, por lo que se realizó biopsia por cateterismo venoso por vía femoral, que permitió hacer el diagnóstico histopatológico y establecer el tratamiento, con lo cual se encuentra en primera remisión completa a un año del evento Abstract in english Cardiac tumors are rare entities in clinical practice, with an incidence of 0.05%. Approximately 75% are benign and 25% malignant. Among these, Lymphomas are uncommon, representing about 0.25%. The non-Hodgkin lymphomas can occur in extranodal tissues in 20% of the cases and 80% of these non-Hodgkin [...] lymphomas are composed of diffuse B cells. The extranodal presentation is most frequent in young adults, with a high degree of malignancy and rapid growth. It can present with primary infiltration of various organs; cardiac involvement occurs in 20 to 28% of cases, usually located in the right chambers and with nonspecific symptoms, depending on the location and extent of the tumor. The diagnostic test in these cases is undoubtedly the biopsy of the lymph node or the affected tissue. We present the case of non-Hodgkin disease of diffuse large cells, with right intra-atrial involvement in a 23-year-old-female patient, who presented with progressive dyspnea. A transesophageal echocardiography was performed and an intra-atrial tumor mass was detected. A biopsy was performed, by femoral venous catheterization, allowing the establishment of the histopathological diagnosis and treatment. At a one year follow up, the patient shows complete remission

Marco Antonio, Alcocer Gamba; Salvador León, González; Eliodoro, Castro Montes; Luis Martín, Loarca Piña; Leslie Marisol, Lugo Gavidia; Enrique, García Hernández; Ulises, González Galindo; Miguel Isaías, Paredes Serrano.

2012-09-01

117

Las Historias de un Tratado Comercial  

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RESUMEN: ¿Cuáles son las razones que han favorecido un tratado de libre comercio en América del Norte? El artículo sugiere algunos de los intereses políticos y económicos inmersos en la negociacián. Como Canadá ya tiene su propio acuerdo con los Estados Unidos, su objetivo fundamental será evitar que México logre beneficios que pudieran perjudicarle. Para México, por su parte, el tratado puede ser la alternativa para recuperar el crecimiento económico, mientras que para Estados...

2009-01-01

118

Intravascular probe for detection of vulnerable plaque  

Science.gov (United States)

Coronary angiography is unable to define the status of the atheroma, and only measures the luminal dimensions of the blood vessel, without providing information about plaque content. Up to 70% of heart attacks are caused by minimally obstructive vulnerable plaques, which are too small to be detected adequately by angiography. We have developed an intravascular imaging detector to identify vulnerable coronary artery plaques. The detector works by sensing beta or conversion electron radiotracer emissions from plaque-binding radiotracers. The device overcomes the technical constraints of size, sensitivity and conformance to the intravascular environment. The detector at the distal end of the catheter uses six 7mm long by 0.5mm diameter scintillation fibers coupled to 1.5m long plastic fibers. The fibers are offset from each other longitudinally by 6mm and arranged spirally around a guide wire in the catheter. At the proximal end of the catheter the optical fibers are coupled to an interface box with a snap on connector. The interface box contains a position sensitive photomultiplier tube (PSPMT) to decode the individual fibers. The whole detector assembly fits into an 8-French (2.7 mm in diameter) catheter. The PSPMT image is further decoded with software to give a linear image, the total instantaneous count rate and an audio output whose tone corresponds to the count rate. The device was tested with F-18 and Tl-204 sources. Spectrometric response, spatial resolution, sensitivity and beta to background ratio were measured. System resolution is 6 mm and the sensitivity is >500 cps / micrometers Ci when the source is 1 mm from the detector. The beta to background ratio was 11.2 for F-18 measured on a single fiber. The current device will lead to a system allowing imaging of labeled vulnerable plaque in coronary arteries. This type of signature is expected to enable targeted and cost effective therapies to prevent acute coronary artery diseases such as: unstable angina, acute myocardial infarction, and sudden cardiac death.

Patt, Bradley E.; Iwanczyk, Jan S.; MacDonald, Lawrence R.; Yamaguchi, Yuko; Tull, Carolyn R.; Janecek, Martin; Hoffman, Edward J.; Strauss, H. William; Tsugita, Ross; Ghazarossian, Vartan

2001-12-01

119

Linfoma primario de pene / Primary lymphoma of penis  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish Se describe un caso de linfoma primario de pene en un paciente de 71 años. Se revisa la bibliografía destacando su extrema rareza y las diferentes formas clínicas de presentación. La clínica fue insidiosa, y los datos de la exploración física y los hallazgos ecográficos la hicieron indistinguible de [...] otras neoplasias. La resonancia magnética confirmó la existencia de un proceso neoformativo de densidad homogénea en la parte distal del pene, cuya toma biópsica junto con las técnicas de inmunohistoquímica confirmó el diagnóstico de linfoma de pene. El tratamiento combinado de quimio y radioterapia permitió conservar el órgano, encontrándose el paciente a los 48 meses libre de enfermedad. Abstract in english We describe a case of primary penis lymphoma in a 71yr old man. We review the bibliography and we emphasize the peculiarity and different sorts of clinical presentation. The initial symptoms were insidious. Physical examination and ultrasound findings made it indistinguishable from other tumors. A M [...] RI confirmed the presence of a tumoral process with a homogeneous density in the distal part of the penis whose biopsy with immune histological processing confirme us the diagnosis of primary penis lymphoma. The combined treatment with chemotherapy and radiotherapy allowed preserving the sexual organ and being without disease at 48 month of follow up.

Lluis, Ibarz Servio; Montserrat, Arzoz Fábregas; José M., Ruiz Domínguez; Montserrat, Batlle Massana; José L., Mate Sanz; José M., Saladié Roig.

2009-08-01

120

Toward a Continuous Intravascular Glucose Monitoring System  

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Full Text Available Proof-of-concept studies that display the potential of using a glucose-sensitive hydrogel as a continuous glucose sensor are presented. The swelling ratio, porosity, and diffusivity of the hydrogel increased with glucose concentration. In glucose solutions of 50, 100, 200, and 300 mg/dL, the hydrogel swelling ratios were 4.9, 12.3, 15.9, and 21.7, respectively, and the swelling was reversible. The impedance across the hydrogel depended solely on the thickness and had an average increase of 47 W/mm. The hydrogels exposed to a hyperglycemic solution were more porous than the hydrogels exposed to a normal glycemic solution. The diffusivity of 390 Da MW fluorescein isothiocyanate in hydrogels exposed to normal and hyperglycemic solutions was examined using fluorescence recovery after photobleaching and was found to be 9.3 × 10?14 and 41.4 × 10?14 m2/s, respectively, compared to 6.2 × 10?10 m2/s in glucose solution. There was no significant difference between the permeability of hydrogels in normal and hyperglycemic glucose solutions with averages being 5.26 × 10?17 m2 and 5.80 × 10?17 m2, respectively, which resembles 2–4% agarose gels. A prototype design is presented for continuous intravascular glucose monitoring by attaching a glucose sensor to an FDA-approved stent.

Pedro Irazoqui

2010-12-01

 
 
 
 
121

The issue of refractory disease in follicular and other lymphoma subtypes / A refratariedade no linfoma folicular e em outros linfomas  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese A evolução dos linfomas tem sido definitivamente melhorada ao longo das últimas décadas. Isto se deve principalmente devido à introdução e desenvolvimento de novas e efetivas abordagens terapêuticas. Apesar disto, uma pequena parcela deste notável grupo de pacientes pode apresentar uma pobre respost [...] a aos tratamentos, com uma verdadeira refratariedade, ou com resposta transitória e precocemente uma recidiva. A presente revisão aborda este assunto da doença refratária nos pacientes com linfoma, enfocando sua incidência global e os principais aspectos clínicos associados à refratariedade. Abstract in english The outcome of lymphoma has definitely improved over the last few decades which is mainly due to the introduction and development of novel and effective therapeutic approaches. Nevertheless, a small though notable group of patients may display a poor response to treatments, with a true refractorines [...] s or a transient response followed by early relapse. The present review addresses the issue of refractory disease among patients with lymphoma, focusing on the overall incidence and the main clinical aspects associated with refractoriness.

Marco, Ruella; Angela, Gueli; Alessandra, Risso; Irene, Ricca; Daniela, Gottardi; Alberto, De Crescenzo; Roberto, Passera; Marco, Ladeto; Corrado, Tarella.

122

The issue of refractory disease in follicular and other lymphoma subtypes A refratariedade no linfoma folicular e em outros linfomas  

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Full Text Available The outcome of lymphoma has definitely improved over the last few decades which is mainly due to the introduction and development of novel and effective therapeutic approaches. Nevertheless, a small though notable group of patients may display a poor response to treatments, with a true refractoriness or a transient response followed by early relapse. The present review addresses the issue of refractory disease among patients with lymphoma, focusing on the overall incidence and the main clinical aspects associated with refractoriness.A evolução dos linfomas tem sido definitivamente melhorada ao longo das últimas décadas. Isto se deve principalmente devido à introdução e desenvolvimento de novas e efetivas abordagens terapêuticas. Apesar disto, uma pequena parcela deste notável grupo de pacientes pode apresentar uma pobre resposta aos tratamentos, com uma verdadeira refratariedade, ou com resposta transitória e precocemente uma recidiva. A presente revisão aborda este assunto da doença refratária nos pacientes com linfoma, enfocando sua incidência global e os principais aspectos clínicos associados à refratariedade.

Marco Ruella

2009-08-01

123

Rotational multispectral fluorescence lifetime imaging and intravascular ultrasound: bimodal system for intravascular applications  

Science.gov (United States)

We report the development and validation of a hybrid intravascular diagnostic system combining multispectral fluorescence lifetime imaging (FLIm) and intravascular ultrasound (IVUS) for cardiovascular imaging applications. A prototype FLIm system based on fluorescence pulse sampling technique providing information on artery biochemical composition was integrated with a commercial IVUS system providing information on artery morphology. A customized 3-Fr bimodal catheter combining a rotational side-view fiberoptic and a 40-MHz IVUS transducer was constructed for sequential helical scanning (rotation and pullback) of tubular structures. Validation of this bimodal approach was conducted in pig heart coronary arteries. Spatial resolution, fluorescence detection efficiency, pulse broadening effect, and lifetime measurement variability of the FLIm system were systematically evaluated. Current results show that this system is capable of temporarily resolving the fluorescence emission simultaneously in multiple spectral channels in a single pullback sequence. Accurate measurements of fluorescence decay characteristics from arterial segments can be obtained rapidly (e.g., 20 mm in 5 s), and accurate co-registration of fluorescence and ultrasound features can be achieved. The current finding demonstrates the compatibility of FLIm instrumentation with in vivo clinical investigations and its potential to complement conventional IVUS during catheterization procedures.

Ma, Dinglong; Bec, Julien; Yankelevich, Diego R.; Gorpas, Dimitris; Fatakdawala, Hussain; Marcu, Laura

2014-06-01

124

Hemostasia normal y coagulación intravascular diseminada en obstetricia / Normal hemostasis and disseminated intravascular clotting in Obstetrics  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish En el período gravido - puerperal, la coagulación sanguínea sufre cambios que se impone conocer para interpretar correctamente esos trastornos cuando se presentan en esta etapa, teniendo en cuenta las posibles complicaciones y el peligro para la vida que pueden presentarse. El objetivo del presente [...] artículo es proporcionar a los obstetras una revisión bibliográfica que les permita actualizarse acerca del tema y facilite su modo de actuación ante pacientes con coagulación intravascular diseminada. Se concluye que es preciso diagnosticar tempranamente el proceso en la fase bioquímica de bajo grado y aplicar en las féminas el tratamiento expedito de la enfermedad de base para eliminar las complicaciones o disminuir su ocurrencia Abstract in english In the period from pregnancy to puerperium, blood clotting suffers changes which are important to be known in order to interpret correctly those dysfunctions when they appear in this stage, keeping in mind the possible complications and the danger for life which can take place. The objective of the [...] present work is to provide the obstetricians a literature review that allows them to be updated about the topic and facilitate their performance in case of patients with disseminated intravascular clotting. It is concluded that it is necessary to have an early diagnosis on the process during the low grade biochemical phase and to apply in these women the expedite treatment of the base disease to eliminate complications or to decrease their occurrence.

Danilo, Nápoles Méndez; Dianela, Nápoles García.

125

Use of intravascular imaging in managing coronary artery disease  

Science.gov (United States)

For many years, coronary angiography has been considered “the gold standard” for evaluating patients with coronary artery disease. However, angiography only provides a planar two-dimensional silhouette of the lumen and is unsuitable for the precise assessment of atherosclerosis. With the introduction of intravascular imaging, direct visualization of the arterial wall is now feasible. Intravascular imaging modalities extend diagnostic information, thereby enabling more precise evaluation of plaque burden and vessel remodeling. Of all technologies, intravascular ultrasound (IVUS) is the most mature and widely used intravascular imaging technique. Optical coherence tomography (OCT) is an evolving technology that has the highest spatial resolution of existing imaging methods, and it is becoming increasingly widespread. These methods are useful tools for planning interventional strategies and optimizing stent deployment, particularly when stenting complex lesions. We strongly support the mandatory use of IVUS for left main percutaneous coronary intervention (PCI). In addition, it can be used to evaluate vascular responses, including neointimal growth and strut apposition, during follow-ups. Adequately powered randomized trials are needed to support IVUS or OCT use in routine clinical practice and to answer whether OCT is superior to IVUS in reducing adverse events when used to guide PCI. The current perception and adoption of innovative interventional devices, such as bioabsorbable scaffolds, will increase the need for intravascular imaging in the future. PMID:24976911

Jegere, Sanda; Narbute, Inga; Erglis, Andrejs

2014-01-01

126

Intravascular brachytherapy for peripheral vascular disease  

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Full Text Available Scientific background: Percutaneous transluminal angioplasties (PTA through balloon dilatation with or without stenting, i.e. vessel expansion through balloons with or without of implantation of small tubes, called stents, are used in the treatment of peripheral artery occlusive disease (PAOD. The intravascular vessel irradiation, called intravascular brachytherapy, promises a reduction in the rate of repeated stenosis (rate of restenosis after PTA. Research questions: The evaluation addresses questions on medical efficacy, cost-effectiveness as well as ethic, social and legal implications in the use of brachytherapy in PAOD patients. Methods: A systematic literature search was conducted in August 2007 in the most important medical electronic databases for publications beginning from 2002. The medical evaluation included randomized controlled trials (RCT. The information synthesis was performed using meta-analysis. Health economic modeling was performed with clinical assumptions derived from the meta-analysis and economical assumptions derived from the German Diagnosis Related Groups (G-DRG-2007. Results: Medical evaluation: Twelve publications about seven RCT on brachytherapy vs. no brachytherapy were included in the medical evaluation. Two RCT showed a significant reduction in the rate of restenosis at six and/or twelve months for brachytherapy vs. no brachytherapy after successful balloon dilatation, the relative risk in the meta-analysis was 0.62 (95% CI: 0.46 to 0.84. At five years, time to recurrence of restenosis was significantly delayed after brachytherapy. One RCT showed a significant reduction in the rate of restenosis at six months for brachytherapy vs. no brachytherapy after PTA with optional stenting, the relative risk in the meta-analysis was 0.76 (95% CI: 0.61 to 0.95. One RCT observed a significantly higher rate of late thrombotic occlusions after brachytherapy in the subgroup of stented patients. A single RCT for brachytherapy vs. no brachytherapy after stenting did not show significant results for the rate of restenosis at six months. Both, early and late thrombotic occlusions appeared more frequently in the brachytherapy group. Health economic evaluation: Additional costs of brachytherapy were estimated to be 1,655 or 1,767 Euro according to the used G-DRG. The incremental cost-effectiveness ratio per avoided restenosis was calculated to be 8,484 Euro or 9,058 Euro for brachytherapy use after successful balloon dilatation, 19,027 Euro or 20,314 Euro for brachytherapy after PTA with optional stenting and -39,646 Euro or -48,330 Euro for brachytherapy after stenting. Discussion: Partially poor performing and reporting quality of the RCT exacerbate the interpretation and the transferability of the study results. The used methodical approach enables the highest evidence level for the determined results and presents a good approximation of the current brachytherapy related costs for the German health care system. Conclusions: Brachytherapy after successful balloon dilatation in PAOD can be recommended from a medical point of view for the reduction of the rate of restenosis at one year. However from a health economic view the answer is not yet clear. Based on the current data the use of brachytherapy after stenting in PAOD cannot be recommended neither from a medical nor from a health economic point of view. The informed consent of the patients is an important ethical aspect in the use of brachytherapy.

Hagen, Anja

2008-09-01

127

The natural history of intravascular lymphomatosis.  

Science.gov (United States)

Intravascular lymphomatosis (IVL) is a rare and clinically devastating form of extranodal B-cell non-Hodgkin's lymphoma. We performed a comprehensive analysis of the literature on IVL's published between 1959 and 2011 and evaluated the natural history as well as identified prognostic and predictive factors in patients. Nonparametric two-tailed Mann-Whitney U-test and Mantel-Cox log rank test were used to evaluate the survival intervals and prognostic factors. Multivariate analysis of variance (MANOVA) and chi-squared statistics were carried out to examine treatment-related predictive factors. Of the 740 patients with IVL, 651 (88%) had a diagnosis of B-cell lymphoma, 45 (6%) with T-cell lymphoma, and 12 patients (2%) with NK cell lymphoma. Central nervous system (CNS) IVL had the highest proportion of postmortem diagnosis, 250 (60%) compared to 21 (8%) of skin, 28 (11%) of bone marrow (BM) and spleen, and 17 (7%) of lung IVL's. Age 71 and LDH >577 compared to nonrituximab, nondoxorubicin regimens (MANOVA 2 degrees of freedom, P = 0.0345), with a median time from treatment to death of 20.0 (95% confidence interval [CI] 14.0-N/A, n = 14) months versus 2.0 (95%CI 0.5-N/A, n = 5) (?(2) = 4.7, P = 0.0304). Patients with CNS IVL relapsed primarily in the CNS (88%) while same-organ relapse occurred less frequently in skin (23%), BM and spleen (50%) and lung (20%) IVL's. Our results indicate that IVL is primarily a disease of B-lymphoma cells. Timely diagnosis and treatment with rituximab-based chemotherapy improve patient survival. The pattern of recurrence is different between CNS IVL and IVL's in other organs. PMID:24931821

Fonkem, Ekokobe; Lok, Edwin; Robison, David; Gautam, Shiva; Wong, Eric T

2014-08-01

128

Linfoma primario del sistema nervioso central en pacientes inmunocompetentes / Primary central nervous system lymphoma in immunocompetent patients  

Scientific Electronic Library Online (English)

Full Text Available SciELO Mexico | Language: Spanish Abstract in spanish El linfoma primario del sistema nervioso central ha sido informado con frecuencia en pacientes que padecen síndromes de inmuno deficiencia. Sin embargo ésta no es una condición necesaria para su presentación, dado que existen informes de la enfermedad en sujetos inmunológicamente competentes. En el [...] presente trabajo se analizaron en forma retrospectiva, los expedientes de 22 pacientes inmunocompetentes con diagnóstico confirmado de linfoma primario encefálico, se revisó la literatura mundial, con el fin de analizar objetivamente las manifestaciones clínicas, comportamiento radiológico, aspecto histopatológico, dificul tades diagnósticas y terapéuticas, así como las consideraciones pro nósticas. El promedio de edad fue de 65 años y con una relación equitativa hombre/mujer. El tiempo de evolución del cuadro clínico fue de 80.4 días y estuvo dominado por cefalea y déficit neurológico focal. En cuatro pacientes se encontraron lesiones múltiples, mientras que en el resto se trataba de lesiones únicas con localización predominante en la región periventricular de los hemisferios cerebrales. Todos los pacientes fueron manejados inicialmente con esteroides y sometidos a toma de biopsia por estereotaxia. La variedad histológica más frecuente fue la de células grandes difusas y la totalidad de los casos reaccionaron positivamente a antígenos de células B en la inmunohistoquímica. Los 22 pacientes fueron tratados con radio terapia y 10 de ellos además con quimioterapia con metotrexato. La supervivencia promedio fue de 11 meses en los pacientes radiados y de 36 meses en los que se agregó quimioterapia. Abstract in english Primary central nervous system lymphoma has been traditionally described in patients with immunodeficiency syndromes; however, there is an increasing number of immunocompetent patients with this type of tumor that have been reported recently. In this paper we have retrospectively analyzed 22 immunoc [...] ompetent patients with a confirmed diagnosis of primary lymphoma of the brain. The mean age in this group was 65 years with a similar male/female ratio. The time of evolution of the clinical course was 80.4 days and it was mainly characterized by headache and focal neurological deficit. In four patients multiple lesions were observed, while the remaining presented single lesions mainly located in the periventricular area of the cerebral hemispheres. All patients were initially administered steroids and a stereotactic biopsy was performed. The majority of tumors were histologically classified as diffuse large cells and all of them showed a positive reaction to B cells antigens on immunohistochemistry. All patients were treated with radiotherapy and in 10 of them, chemotherapy with methotrexate was also indicated. The mean survival rate was 11 months among patients treated with radiotherapy alone and increased to 36 months when chemotherapy was added.

Gerardo, Guinto-Balanzar; Ignacio, Félix-Espinoza; Salvador, De Anda Ponce-de -León; Norma C, Aréchiga-Ramos; Víctor, Arteaga-Larios; Kalman, Kovacs.

2005-12-01

129

Linfoma primario del sistema nervioso central en pacientes inmunocompetentes / Primary central nervous system lymphoma in immunocompetent patients  

Scientific Electronic Library Online (English)

Full Text Available SciELO Mexico | Language: Spanish Abstract in spanish El linfoma primario del sistema nervioso central ha sido informado con frecuencia en pacientes que padecen síndromes de inmuno deficiencia. Sin embargo ésta no es una condición necesaria para su presentación, dado que existen informes de la enfermedad en sujetos inmunológicamente competentes. En el [...] presente trabajo se analizaron en forma retrospectiva, los expedientes de 22 pacientes inmunocompetentes con diagnóstico confirmado de linfoma primario encefálico, se revisó la literatura mundial, con el fin de analizar objetivamente las manifestaciones clínicas, comportamiento radiológico, aspecto histopatológico, dificul tades diagnósticas y terapéuticas, así como las consideraciones pro nósticas. El promedio de edad fue de 65 años y con una relación equitativa hombre/mujer. El tiempo de evolución del cuadro clínico fue de 80.4 días y estuvo dominado por cefalea y déficit neurológico focal. En cuatro pacientes se encontraron lesiones múltiples, mientras que en el resto se trataba de lesiones únicas con localización predominante en la región periventricular de los hemisferios cerebrales. Todos los pacientes fueron manejados inicialmente con esteroides y sometidos a toma de biopsia por estereotaxia. La variedad histológica más frecuente fue la de células grandes difusas y la totalidad de los casos reaccionaron positivamente a antígenos de células B en la inmunohistoquímica. Los 22 pacientes fueron tratados con radio terapia y 10 de ellos además con quimioterapia con metotrexato. La supervivencia promedio fue de 11 meses en los pacientes radiados y de 36 meses en los que se agregó quimioterapia. Abstract in english Primary central nervous system lymphoma has been traditionally described in patients with immunodeficiency syndromes; however, there is an increasing number of immunocompetent patients with this type of tumor that have been reported recently. In this paper we have retrospectively analyzed 22 immunoc [...] ompetent patients with a confirmed diagnosis of primary lymphoma of the brain. The mean age in this group was 65 years with a similar male/female ratio. The time of evolution of the clinical course was 80.4 days and it was mainly characterized by headache and focal neurological deficit. In four patients multiple lesions were observed, while the remaining presented single lesions mainly located in the periventricular area of the cerebral hemispheres. All patients were initially administered steroids and a stereotactic biopsy was performed. The majority of tumors were histologically classified as diffuse large cells and all of them showed a positive reaction to B cells antigens on immunohistochemistry. All patients were treated with radiotherapy and in 10 of them, chemotherapy with methotrexate was also indicated. The mean survival rate was 11 months among patients treated with radiotherapy alone and increased to 36 months when chemotherapy was added.

Gerardo, Guinto-Balanzar; Ignacio, Félix-Espinoza; Salvador, De Anda Ponce-de -León; Norma C, Aréchiga-Ramos; Víctor, Arteaga-Larios; Kalman, Kovacs.

130

Emergency treatment by intravascular embolization in traumatic carotid cavernous fistula  

International Nuclear Information System (INIS)

Objective: To discuss the method of intervenfional intravascular treatment in traumatic carotid cavernous fistula (TCCF) and the significance of clinical application in emergency. Methods: In 297 eases of TCCF, 36 cases were treated by interventional intravascular embolization by detachable balloon, embolization orificium or occlusion in one side of carotid artery. In the 36 cases, serious epistaxis occurred in 22 eases, cortical vein inflow in 9 cases, intracranial hemorrhage in 3 cases, aggravation of eyesight in 3 cases, and limb dysfunction in 2 cases. Results: Fistula was successfully embolized and internal carotid artery remained patent in 19 cases. Complete embolization of orificium or internal carotid artery was achieved in 17 eases. The serious epistaxias in 22 cases and intracranial hemorrhage in 3 cases stopped. Eyesight recovered in 2 eases and improved in 1 case. Limb dysfunction improved evidently in 2 cases. Conclusion: Intravascular embolization treatment is the first therapeutic choice for TCCF, especially in emergency. It is necessary, safe and effective. (authors)

131

Chronic disseminated intravascular coagulation presenting as renal mass  

Directory of Open Access Journals (Sweden)

Full Text Available Disseminated intravascular coagulation (DIC is a complex clinical syndrome, described as a sequential activation of the coagulation and fibrinolytic system. Trauma and sepsis are some of the known precipitating factors. We report a case of nonovert disseminated intravascular coagulation presenting as a huge renal mass in a 3-year-old child, suspected to be a Wilms? tumor. On imaging studies, it was found to be a renal hematoma. Laboratory investigations revealed an underlying chronic disseminated intravascular coagulation caused by sepsis. The child recovered with conservative treatment; follow up investigations showed resolution of renal hematoma with renal function returning to base line. Clinical presentation of Chronic DIC is variable. Laboratory investigations usually help to diagnose the condition and also to monitor the progress of the treatment. The treatment of the triggering cause is the cornerstone of the management of this condition.

Somashekhar Manjiri

2008-01-01

132

Linfomas no hodgkinianos agresivos: ¿Después del CHOP sólo el CHOP?  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Los lactatos de deshidrogenasa agresivos incluyen a estos linfomas no hodgkianos difusos de células grandes B (incluida la variante del linfoma B primario del mediastino), los de células grandes anaplásicos T y nulos y los T periféricos. Un índice pronóstico internacional fue creado e incluye la eda [...] d, sus niveles séricos de lactato de deshidrogenasa performance status y la afectación extranodal. El esquema CHOP se considera la regla de oro de los LNH agresivos, tanto esta patología limitada como avanzada. Los pacientes con patología diseminada tienen índices de curabilidad menor de un 40 % por lo que se ensayan múltiples estrategias terapéuticas para mejorar estos resultados, dentro de éstas se ha demostrado que es posible escalar la dosis de los fármacos pilares en el esquema CHOP, hasta aproximadamente el doble del estándar con una toxicidad aceptada y mejores respuestas. Abstract in english The aggressive NHLs (non-Hodgkin lymphomas) comprise the diffuse large B-cell NHLs (including the variant of primary mediastinal B-cell lymphoma), the anaplastic and null large T-cell lymphomas and the peripheral T-cell lymphomas. An international prognostic index was created taking into account age [...] , serum levels of LDH, Performance Status and extranodal affection. The CHOP scheme is considered as the gold standard of those non-Hodgkin’s lymphoma of aggressive histology, both in limited and advanced disease. Patients with disseminated disease have curability indexes under 40 %, so multiple therapeutic strategies are being tested to improve these results. It has been found that it is possible to increase the dose of the main drugs in the CHOP schemes up to approximately the double of the standard with an accepted toxicity and better responses.

Fernando, Areces Delgado; Delvys, Rodríguez Abreu.

133

A study of intravascular brachytherapy treatment planning in peripheral arteries  

Science.gov (United States)

A two-step method to determine the seed parameters for the planning of peripheral intravascular brachytherapy, which took the actual vessel geometry into consideration, was developed. Firstly, the characteristics of the vessel geometry was obtained by using active navigation; Then a method combined genetic algorithm with BFGS algorithm was applied to optimize the number of seeds, and the parameters associated with each seed such as the position, and the dwell time. Application of the method to a phantom model and three animal models of stenosis shows that promising result could be obtained, and the planning of peripheral intravascular brachytherapy should take actual vessel geometry into consideration. PMID:17282698

Zhou, Zhengdong; Haigron, Pascal; Shu, Huazhong; Yu, Wenxue; Acosta, Oscar; Manens, Jean-Pierre; Lucas, Antoine; Luo, Liming

2005-01-01

134

A study of intravascular brachytherapy treatment planning in peripheral arteries.  

Science.gov (United States)

A two-step method to determine the seed parameters for the planning of peripheral intravascular brachytherapy, which took the actual vessel geometry into consideration, was developed. Firstly, the characteristics of the vessel geometry was obtained by using active navigation; Then a method combined genetic algorithm with BFGS algorithm was applied to optimize the number of seeds, and the parameters associated with each seed such as the position, and the dwell time. Application of the method to a phantom model and three animal models of stenosis shows that promising result could be obtained, and the planning of peripheral intravascular brachytherapy should take actual vessel geometry into consideration. PMID:17282698

Zhou, Zhengdong; Haigron, Pascal; Acosta, Oscar; Shu, Huazhong; Yu, Wenxue; Luo, Liming; Manens, Jean-Pierre; Lucas, Antoine

2005-01-01

135

Hiperplasia endotelial papilar intravascular oral: uma entidade rara Intravascular papillary endothelial hyperplasia: a rare entity  

Directory of Open Access Journals (Sweden)

Full Text Available A hiperplasia endotelial papilar intravascular (HEPI é uma lesão vascular reativa caracterizada pela proliferação endotelial excessiva localizada no interior de vasos sangüíneos comumente dilatados, associada a trombos em organização, ou secundária a outras lesões vasculares, como hemangiomas e granulomas piogênicos. A HEPI é um achado incomum na cavidade oral, onde os lábios são o principal sítio de acometimento, e surge clinicamente sob a forma de nódulos azulados de aspecto clínico semelhante ao de lesões como hemangioma, mucocele e varicosidades. Sob o aspecto histopatológico, observam-se projeções papilares de tecido conjuntivo fibroso revestidas por uma ou duas camadas de células endoteliais no interior de um lúmen vascular. A principal peculiaridade da HEPI reside em sua semelhança histológica com o angiossarcoma e na possível interpretação errônea como neoplasia maligna. Neste artigo, os autores descrevem um caso de HEPI oral e realizam uma breve revisão da literatura, enfatizando suas características histopatológicas e o diagnóstico diferencial.Intravascular papillary endothelial hyperplasia (IPEH is a reactive vascular lesion characterized by excessive endothelial proliferation within a vascular lumen of commonly dilated vessels, associated to organizing thrombi or even secondary to other vascular lesions, such as hemagiomas and pyogenic granulomas. Oral lesions of IPEH are uncommon, being lips the most frequent site, followed by, in decreasing frequency, tongue and buccal mucosa. Clinically, IPEH appears as bluish nodules that resembles clinical features of lesions as hemangioma, mucocele and varice. On histopathological examination, IPEH presents as papillary projections composed by a fibrous core lined by one or two layers of plump endothelial cells, without evidence of celullar pleomorphism, mitotic activity or necrosis. The mean peculiarity of IPEH is its histologic similarity to angiosarcoma and possible misinterpretation with malignant neoplasm. In this article, the author describe a rare case of oral IPEH and review of literature, emphasizing its histopathologic features and diferencial diagnosis.

João Augusto Vianna Goulart Filho

2006-02-01

136

Linfoma B difuso de células grandes: factores pronósticos en la era del rituximab / Diffuse large B cell lymphoma: prognostic factors in the rituximab era  

Scientific Electronic Library Online (English)

Full Text Available SciELO Colombia | Language: Spanish Abstract in spanish Introducción: la inclusión del rituximab para el tratamiento del linfoma B difuso de células grandes generó la necesidad de reevaluar los factores pronósticos que se empleaban convencionalmente, y la de explorar otros que podrían resultar útiles para establecer el pronóstico. Objetivo: describir los [...] principales factores clínicos, hematológicos, bioquímicos e inmunohistoquímicos que han sido útiles para el pronóstico en estudios de seguimiento de pacientes con linfoma B difuso de células grandes tratados con esquemas de quimioterapia que contenían rituximab. Resultados: entre los factores con significancia para el pronóstico se encontraron el Índice Pronóstico Internacional (IPI) revisado, la infiltración de la médula ósea, la presencia de masa voluminosa, la expresión de CD5 y el porcentaje de expresión de Ki-67; en contraste, es controversial la aplicación de otros factores como el IPI convencional, la expresión de Bcl-2, Bcl-6 y el perfil inmunohistoquímico. Abstract in english Introduction: The inclusion of rituximab for treatment of diffuse large B cell lymphoma (DLBCL) generated the need to re-assess the conventionally employed prognostic factors and to explore others that could be useful for prognostic purposes. Objective: To describe the most important clinical, hemat [...] ological, biochemical and immunohistochemical factors that have been useful for prognostic purposes in follow-up studies of patients with DLBCL treated with chemotherapy plus rituximab. Results: The following factors were found to have prognostic significance: the revised International Prognostic Index, bone marrow infiltration, the presence of a bulky mass, CD5 expression and the percentage of Ki-67 expression. Contrariwise, the application of other factors remains controversial: conventional IPI, Bcl-2 and Bcl-6 expression, and the immunohistochemical profile.

Natalia María, Guevara Arismendy; Patricia Elena, Jaramillo Arbeláez; Lina María, Gaviria Jaramillo.

2013-07-01

137

Linfoma B difuso de células grandes: factores pronósticos en la era del rituximab / Diffuse large B cell lymphoma: prognostic factors in the rituximab era  

Scientific Electronic Library Online (English)

Full Text Available SciELO Colombia | Language: Spanish Abstract in spanish Introducción: la inclusión del rituximab para el tratamiento del linfoma B difuso de células grandes generó la necesidad de reevaluar los factores pronósticos que se empleaban convencionalmente, y la de explorar otros que podrían resultar útiles para establecer el pronóstico. Objetivo: describir los [...] principales factores clínicos, hematológicos, bioquímicos e inmunohistoquímicos que han sido útiles para el pronóstico en estudios de seguimiento de pacientes con linfoma B difuso de células grandes tratados con esquemas de quimioterapia que contenían rituximab. Resultados: entre los factores con significancia para el pronóstico se encontraron el Índice Pronóstico Internacional (IPI) revisado, la infiltración de la médula ósea, la presencia de masa voluminosa, la expresión de CD5 y el porcentaje de expresión de Ki-67; en contraste, es controversial la aplicación de otros factores como el IPI convencional, la expresión de Bcl-2, Bcl-6 y el perfil inmunohistoquímico. Abstract in english Introduction: The inclusion of rituximab for treatment of diffuse large B cell lymphoma (DLBCL) generated the need to re-assess the conventionally employed prognostic factors and to explore others that could be useful for prognostic purposes. Objective: To describe the most important clinical, hemat [...] ological, biochemical and immunohistochemical factors that have been useful for prognostic purposes in follow-up studies of patients with DLBCL treated with chemotherapy plus rituximab. Results: The following factors were found to have prognostic significance: the revised International Prognostic Index, bone marrow infiltration, the presence of a bulky mass, CD5 expression and the percentage of Ki-67 expression. Contrariwise, the application of other factors remains controversial: conventional IPI, Bcl-2 and Bcl-6 expression, and the immunohistochemical profile.

Natalia María, Guevara Arismendy; Patricia Elena, Jaramillo Arbeláez; Lina María, Gaviria Jaramillo.

138

Quilotórax bilateral y linfoma simultáneo en dos varones: presentación de dos casos / Bilateral chylothorax and simultaneous lymphoma in two male patients: report of two cases  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Fundamento: el quilotórax es una enfermedad grave, más aún si es bilateral y de causa maligna, pero tiene tratamiento y el enfermo puede estabilizarse. Objetivo: presentar dos pacientes de interés médico y demostrar que puede esperarse buena respuesta al tratamiento. Casos Clínicos: se presentaron d [...] os enfermos portadores de quilotórax bilateral y linfoma, ambos varones, atendidos en el hospital de forma simultánea; se realizaron los exámenes complementarios diagnósticos. El diagnóstico en ambos resultó linfoma no Hodgkin y Hodgkin respectivamente, fueron tratados con dieta, se restringieron las grasas; tratamiento oncoespecÍfico y toracocentésis repetidas en ambos hemitórax. El primero, mejorado del derrame bilateral y síntomas inicialmente, fallece a los 11 meses por no control de su enfermedad base. El segundo, estable de ambas afecciones a los 18 meses, en ambos casos el quilotórax se compensó y no fue necesario repetir drenaje. Se hacen análisis comparativo con otros reportes sobre todo cuando el linfoma es la causa etiológica, la conducta adoptada concuerda con otros estudios actuales. Conclusiones: los enfermos mejoraron del quilotórax bilateral, uno no estabilizó su enfermedad de base y murió, mientras el otro está asintomático. Puede obtenerse buena respuesta terapéutica. Abstract in english Background: chylothorax is a serious disease, even more if it is bilateral and of a malignant cause; but it has treatment and the patient’s condition may be stable. Objective: to present two patients of medical interest and prove that a good response from the treatment may be expected. Clinical case [...] s: two male patients with bilateral chylothorax and lymphoma were simultaneously attended at the hospital. Complementary diagnostic tests were made. The diagnosis of both patients turned out to be non-Hodgkin’s and Hodgkin’s lymphomas respectively. They were put on a diet in which fat was cut; the oncospecific treatment and repeated thoracocentesis were applied in both hemithoraxes. The first patient, after getting better from the bilateral effusion and initial symptoms, passed away 11 months later for not controlling the base disease. The second patient presented a stable condition of both complaints 18 months later. In both cases chylotorax was eased and it was not necessary to repeat the drainage. Analyses compared to other reports are made mainly when the lymphoma is the etiological cause; the adopted conduct coincides with other current studies. Conclusions: the patients got better from bilateral chylothorax; one of them did not get a stable condition of his base disease and died and the second one is asymptomatic. A good therapeutic response may be obtained.

Karina, Armas Moredo; Yamilet, Santos Herrera; Orlando E., Olivera Morán; Miguel Emilio, García Rodríguez; Bárbaro Agustín, Armas Pérez.

2014-02-01

139

Síndrome de vena cava superior: Una emergencia oncológica en niños con linfoma. Revisión de 5 casos / Superior Vena Cava Syndrome: an oncologic emergency in children with lymphoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Chile | Language: Spanish Abstract in spanish Introducción: Un niño con cáncer puede presentar durante su enfermedad una emergencia, ya sea como manifestación inicial, en la fase de diagnóstico, durante la evolución o en el periodo terminal. Objetivo: Presentar nuestra experiencia en el manejo del síndrome de Vena Cava Superior en niños con lin [...] foma. Pacientes y Método: Revisión retrospectiva de 44 fichas clínicas de menores de 15 años con linfoma tratados entre enero de 1989 y diciembre de 1999 en la Unidad de Hematología/Oncología Infantil del Hospital Clínico Regional de Valdivia. Resultados: 5 casos presentaron síndrome de Vena Cava Superior: Linfoma de Hodgkin 2. Linfoma no Hodgkin 3. El síndrome de Vena Cava Superior fue la manifestación inicial en 4. En la emergencia todos los pacientes recibieron corticoides y radioterapia. Tres pacientes se encuentran vivos y en remisión completa. Conclusiones: El síndrome de Vena Cava Superior, es poco frecuente en niños con patología tumoral, sin embargo, por constituir una emergencia médica requiere tratamiento inmediato, necesitándose claras pautas de manejo Abstract in english Introduction: A child with cancer may have an oncologic emergency during one of the following situations: A) Primary manifestation of the disease. B) Diagnostic phase. C) During clinical evolution of the disease. D) Terminal stage. Objective: To review our experience in the management of patients wi [...] th lymphoma presenting with Superior Vena Cava Syndrome (SVCS). Method: Retrospective analysis of clinical data of 44 patients younger than 15 years-old affected with lymphoma and treated at the Hemathology/Oncology Unit of the Clinical Hospital from Valdivia, between 1989 and 1999. Results: 5 patients presented SVCS; 2 of them had Hodgkin lymphoma and 3 had no-Hodgkin lymphoma. The SVCS was the first clinical manifestation in 4 of them. During the emergency, all patients were treated with steroids and radiotherapy, observing 3 of them still alive and free of disease. Conclusions: The SVCS is a rare complication in pediatric tumoral disease. It constitutes an oncologic emergency that we ought to know in terms of diagnosis and treatment

Miriam, Davis G.; Paola, Zolezzi R.; Nilda, Zumelzu D..

2005-10-01

140

Síndrome de vena cava superior: Una emergencia oncológica en niños con linfoma. Revisión de 5 casos / Superior Vena Cava Syndrome: an oncologic emergency in children with lymphoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Chile | Language: Spanish Abstract in spanish Introducción: Un niño con cáncer puede presentar durante su enfermedad una emergencia, ya sea como manifestación inicial, en la fase de diagnóstico, durante la evolución o en el periodo terminal. Objetivo: Presentar nuestra experiencia en el manejo del síndrome de Vena Cava Superior en niños con lin [...] foma. Pacientes y Método: Revisión retrospectiva de 44 fichas clínicas de menores de 15 años con linfoma tratados entre enero de 1989 y diciembre de 1999 en la Unidad de Hematología/Oncología Infantil del Hospital Clínico Regional de Valdivia. Resultados: 5 casos presentaron síndrome de Vena Cava Superior: Linfoma de Hodgkin 2. Linfoma no Hodgkin 3. El síndrome de Vena Cava Superior fue la manifestación inicial en 4. En la emergencia todos los pacientes recibieron corticoides y radioterapia. Tres pacientes se encuentran vivos y en remisión completa. Conclusiones: El síndrome de Vena Cava Superior, es poco frecuente en niños con patología tumoral, sin embargo, por constituir una emergencia médica requiere tratamiento inmediato, necesitándose claras pautas de manejo Abstract in english Introduction: A child with cancer may have an oncologic emergency during one of the following situations: A) Primary manifestation of the disease. B) Diagnostic phase. C) During clinical evolution of the disease. D) Terminal stage. Objective: To review our experience in the management of patients wi [...] th lymphoma presenting with Superior Vena Cava Syndrome (SVCS). Method: Retrospective analysis of clinical data of 44 patients younger than 15 years-old affected with lymphoma and treated at the Hemathology/Oncology Unit of the Clinical Hospital from Valdivia, between 1989 and 1999. Results: 5 patients presented SVCS; 2 of them had Hodgkin lymphoma and 3 had no-Hodgkin lymphoma. The SVCS was the first clinical manifestation in 4 of them. During the emergency, all patients were treated with steroids and radiotherapy, observing 3 of them still alive and free of disease. Conclusions: The SVCS is a rare complication in pediatric tumoral disease. It constitutes an oncologic emergency that we ought to know in terms of diagnosis and treatment

Miriam, Davis G.; Paola, Zolezzi R.; Nilda, Zumelzu D..

 
 
 
 
141

Quilotórax bilateral y linfoma simultáneo en dos varones: presentación de dos casos / Bilateral chylothorax and simultaneous lymphoma in two male patients: report of two cases  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Fundamento: el quilotórax es una enfermedad grave, más aún si es bilateral y de causa maligna, pero tiene tratamiento y el enfermo puede estabilizarse. Objetivo: presentar dos pacientes de interés médico y demostrar que puede esperarse buena respuesta al tratamiento. Casos Clínicos: se presentaron d [...] os enfermos portadores de quilotórax bilateral y linfoma, ambos varones, atendidos en el hospital de forma simultánea; se realizaron los exámenes complementarios diagnósticos. El diagnóstico en ambos resultó linfoma no Hodgkin y Hodgkin respectivamente, fueron tratados con dieta, se restringieron las grasas; tratamiento oncoespecÍfico y toracocentésis repetidas en ambos hemitórax. El primero, mejorado del derrame bilateral y síntomas inicialmente, fallece a los 11 meses por no control de su enfermedad base. El segundo, estable de ambas afecciones a los 18 meses, en ambos casos el quilotórax se compensó y no fue necesario repetir drenaje. Se hacen análisis comparativo con otros reportes sobre todo cuando el linfoma es la causa etiológica, la conducta adoptada concuerda con otros estudios actuales. Conclusiones: los enfermos mejoraron del quilotórax bilateral, uno no estabilizó su enfermedad de base y murió, mientras el otro está asintomático. Puede obtenerse buena respuesta terapéutica. Abstract in english Background: chylothorax is a serious disease, even more if it is bilateral and of a malignant cause; but it has treatment and the patient’s condition may be stable. Objective: to present two patients of medical interest and prove that a good response from the treatment may be expected. Clinical case [...] s: two male patients with bilateral chylothorax and lymphoma were simultaneously attended at the hospital. Complementary diagnostic tests were made. The diagnosis of both patients turned out to be non-Hodgkin’s and Hodgkin’s lymphomas respectively. They were put on a diet in which fat was cut; the oncospecific treatment and repeated thoracocentesis were applied in both hemithoraxes. The first patient, after getting better from the bilateral effusion and initial symptoms, passed away 11 months later for not controlling the base disease. The second patient presented a stable condition of both complaints 18 months later. In both cases chylotorax was eased and it was not necessary to repeat the drainage. Analyses compared to other reports are made mainly when the lymphoma is the etiological cause; the adopted conduct coincides with other current studies. Conclusions: the patients got better from bilateral chylothorax; one of them did not get a stable condition of his base disease and died and the second one is asymptomatic. A good therapeutic response may be obtained.

Karina, Armas Moredo; Yamilet, Santos Herrera; Orlando E., Olivera Morán; Miguel Emilio, García Rodríguez; Bárbaro Agustín, Armas Pérez.

142

Linfomas asociados a infección por VIH en pacientes del Hospital Clínico San Borja Arriarán / Fundación Arriarán2001-2008 / Lymphomas associated with HIV infection in patients at the Hospital San Borja Arriarán /Fundación Arriarán 2001-2008, Santiago, Chile  

Scientific Electronic Library Online (English)

Full Text Available SciELO Chile | Language: Spanish Abstract in spanish Introducción: Los linfomas de Hodgkin (LH) y no Hodgkin (LNH) se asocian con alta frecuencia al síndrome de inmunodeficiencia humana en adultos. Objetivo: Sistematizar los aspectos clínicos e histológicos de los linfoma que afectan a pacientes con SIDA, su tratamiento y resultados globales en nuestr [...] a institución. Pacientes y Métodos: Análisis retrospectivo de pacientes con linfoma asociado a VIH entre enero de 2001 y diciembre de 2008 en el complejo hospitalario San Borja Arriarán. Resultados: Se obtuvo información de 30 pacientes con LNH y 7 LH, con una mediana de 40 años. Los tipos histológicos predominantes fueron linfoma de Burkitt (47 %), linfoma difuso de células grandes de estirpe B (37 %) y LNH de estirpe T (10%). No se diagnosticaron LNH del SNC ni linfoma de cavidades. Casi la totalidad de los pacientes (86,7%) con LNH se trataron con esquema CHOP, 57% de quienes recibieron tratamiento presentaron progresión o recaída desde remisión completa, ofreciéndoles una quimioterapia de rescate a cuatro pacientes. El 73% de los pacientes que recibieron CHOP lograron completar entre cinco y seis ciclos de quimioterapia. El uso de quimioterapia CHOP para el subgrupo de pacientes con linfoma de Burkitt alcanzó bajos porcentajes de remisión completa y mayoritariamente progresó la enfermedad, siendo esta quimioterapia, inefectiva para mejorar la sobrevida, especialmente en los pacientes de riesgo alto. Se encontraron diferencias estadísticamente significativas en sobrevida según el IPIae (índice internacional pronóstico ajustado por edad) al ingreso. Conclusión: El LNH en los pacientes con VIH tratados con los protocolos de quimioterapia PANDA persiste en nuestro medio como una enfermedad de muy mal pronóstico comparado con los resultados en la literatura internacional. La incorporación de nuevos fármacos de demostrada utilidad como rituximab y esquemas específicos de quimioterapia podrían mejorar estos resultados. El establecimiento de grupos pronósticos establecidos por IPIae puede orientar el trabajo clínico para el uso de quimioterapia ajustada a su riesgo específico y optimizado según tipo histológico. Abstract in english Introduction: Hodgkin lymphomas (HL) and non Hodgkin lymphomas (NHL) are frequently associated to acquired immunodeficiency syndrome in adults. Objective: To systematize the clinical features and histological characteristics of lymphomas in AIDS patients, its treatment and outcomes in our institutio [...] n. Patients and Methods: Retrospective analysis of patients with HIV-associated lymphoma between January 2001 and December 2008 at the San Borja Arriarán Hospital complex. Results: Information was obtained from 30 patients with NHL and 7 with HL, with a median of 40 years. The majority of tumors were Burkitt lymphoma (47%), diffuse large cell lymphoma B-cell (37%) and NHL of T lineage (10%). There was no CNS or cavities lymphoma. Almost all patients (86.7%) with NHL were treated with CHOP chemotherapy, 57% of those receiving treatment had progression or relapse from complete remission. A rescue chemotherapy was indicated in 4 patients. 73% of patients receiving CHOP, complete 5 to 6 cycles of chemotherapy. The use of CHOP chemotherapy for the subgroup of patients with Burkitt lymphoma achieved low rates of complete remission and frequent relapse and disease progression, showing that CHOP was ineffective in improving survival, especially in high risk patients. We found statistically significant differences in survival according to IPIae (International prognostic Index age-adjusted). Conclusion: Non-Hodgkin lymphoma in HIV patients treated with chemotherapy protocols PAlNDA persists in our environment as a disease with a poor prognosis compared with findings in the international literature. The incorporation of new drugs of proven utility as rituximab and specific schemes chemotherapy could improve these results. The establishment of prognostic groups established by IPIae can guide clinical

Álvaro, Pizarro; Hernán, García; Ana, Riquelme; Javiera, Carmona; Claudia, Cortés.

2013-02-01

143

Linfomas asociados a infección por VIH en pacientes del Hospital Clínico San Borja Arriarán / Fundación Arriarán2001-2008 / Lymphomas associated with HIV infection in patients at the Hospital San Borja Arriarán /Fundación Arriarán 2001-2008, Santiago, Chile  

Scientific Electronic Library Online (English)

Full Text Available SciELO Chile | Language: Spanish Abstract in spanish Introducción: Los linfomas de Hodgkin (LH) y no Hodgkin (LNH) se asocian con alta frecuencia al síndrome de inmunodeficiencia humana en adultos. Objetivo: Sistematizar los aspectos clínicos e histológicos de los linfoma que afectan a pacientes con SIDA, su tratamiento y resultados globales en nuestr [...] a institución. Pacientes y Métodos: Análisis retrospectivo de pacientes con linfoma asociado a VIH entre enero de 2001 y diciembre de 2008 en el complejo hospitalario San Borja Arriarán. Resultados: Se obtuvo información de 30 pacientes con LNH y 7 LH, con una mediana de 40 años. Los tipos histológicos predominantes fueron linfoma de Burkitt (47 %), linfoma difuso de células grandes de estirpe B (37 %) y LNH de estirpe T (10%). No se diagnosticaron LNH del SNC ni linfoma de cavidades. Casi la totalidad de los pacientes (86,7%) con LNH se trataron con esquema CHOP, 57% de quienes recibieron tratamiento presentaron progresión o recaída desde remisión completa, ofreciéndoles una quimioterapia de rescate a cuatro pacientes. El 73% de los pacientes que recibieron CHOP lograron completar entre cinco y seis ciclos de quimioterapia. El uso de quimioterapia CHOP para el subgrupo de pacientes con linfoma de Burkitt alcanzó bajos porcentajes de remisión completa y mayoritariamente progresó la enfermedad, siendo esta quimioterapia, inefectiva para mejorar la sobrevida, especialmente en los pacientes de riesgo alto. Se encontraron diferencias estadísticamente significativas en sobrevida según el IPIae (índice internacional pronóstico ajustado por edad) al ingreso. Conclusión: El LNH en los pacientes con VIH tratados con los protocolos de quimioterapia PANDA persiste en nuestro medio como una enfermedad de muy mal pronóstico comparado con los resultados en la literatura internacional. La incorporación de nuevos fármacos de demostrada utilidad como rituximab y esquemas específicos de quimioterapia podrían mejorar estos resultados. El establecimiento de grupos pronósticos establecidos por IPIae puede orientar el trabajo clínico para el uso de quimioterapia ajustada a su riesgo específico y optimizado según tipo histológico. Abstract in english Introduction: Hodgkin lymphomas (HL) and non Hodgkin lymphomas (NHL) are frequently associated to acquired immunodeficiency syndrome in adults. Objective: To systematize the clinical features and histological characteristics of lymphomas in AIDS patients, its treatment and outcomes in our institutio [...] n. Patients and Methods: Retrospective analysis of patients with HIV-associated lymphoma between January 2001 and December 2008 at the San Borja Arriarán Hospital complex. Results: Information was obtained from 30 patients with NHL and 7 with HL, with a median of 40 years. The majority of tumors were Burkitt lymphoma (47%), diffuse large cell lymphoma B-cell (37%) and NHL of T lineage (10%). There was no CNS or cavities lymphoma. Almost all patients (86.7%) with NHL were treated with CHOP chemotherapy, 57% of those receiving treatment had progression or relapse from complete remission. A rescue chemotherapy was indicated in 4 patients. 73% of patients receiving CHOP, complete 5 to 6 cycles of chemotherapy. The use of CHOP chemotherapy for the subgroup of patients with Burkitt lymphoma achieved low rates of complete remission and frequent relapse and disease progression, showing that CHOP was ineffective in improving survival, especially in high risk patients. We found statistically significant differences in survival according to IPIae (International prognostic Index age-adjusted). Conclusion: Non-Hodgkin lymphoma in HIV patients treated with chemotherapy protocols PAlNDA persists in our environment as a disease with a poor prognosis compared with findings in the international literature. The incorporation of new drugs of proven utility as rituximab and specific schemes chemotherapy could improve these results. The establishment of prognostic groups established by IPIae can guide clinical

Álvaro, Pizarro; Hernán, García; Ana, Riquelme; Javiera, Carmona; Claudia, Cortés.

144

Linfomas asociados a infección por VIH en pacientes del Hospital Clínico San Borja Arriarán / Fundación Arriarán2001-2008 Lymphomas associated with HIV infection in patients at the Hospital San Borja Arriarán /Fundación Arriarán 2001-2008, Santiago, Chile  

Directory of Open Access Journals (Sweden)

Full Text Available Introducción: Los linfomas de Hodgkin (LH y no Hodgkin (LNH se asocian con alta frecuencia al síndrome de inmunodeficiencia humana en adultos. Objetivo: Sistematizar los aspectos clínicos e histológicos de los linfoma que afectan a pacientes con SIDA, su tratamiento y resultados globales en nuestra institución. Pacientes y Métodos: Análisis retrospectivo de pacientes con linfoma asociado a VIH entre enero de 2001 y diciembre de 2008 en el complejo hospitalario San Borja Arriarán. Resultados: Se obtuvo información de 30 pacientes con LNH y 7 LH, con una mediana de 40 años. Los tipos histológicos predominantes fueron linfoma de Burkitt (47 %, linfoma difuso de células grandes de estirpe B (37 % y LNH de estirpe T (10%. No se diagnosticaron LNH del SNC ni linfoma de cavidades. Casi la totalidad de los pacientes (86,7% con LNH se trataron con esquema CHOP, 57% de quienes recibieron tratamiento presentaron progresión o recaída desde remisión completa, ofreciéndoles una quimioterapia de rescate a cuatro pacientes. El 73% de los pacientes que recibieron CHOP lograron completar entre cinco y seis ciclos de quimioterapia. El uso de quimioterapia CHOP para el subgrupo de pacientes con linfoma de Burkitt alcanzó bajos porcentajes de remisión completa y mayoritariamente progresó la enfermedad, siendo esta quimioterapia, inefectiva para mejorar la sobrevida, especialmente en los pacientes de riesgo alto. Se encontraron diferencias estadísticamente significativas en sobrevida según el IPIae (índice internacional pronóstico ajustado por edad al ingreso. Conclusión: El LNH en los pacientes con VIH tratados con los protocolos de quimioterapia PANDA persiste en nuestro medio como una enfermedad de muy mal pronóstico comparado con los resultados en la literatura internacional. La incorporación de nuevos fármacos de demostrada utilidad como rituximab y esquemas específicos de quimioterapia podrían mejorar estos resultados. El establecimiento de grupos pronósticos establecidos por IPIae puede orientar el trabajo clínico para el uso de quimioterapia ajustada a su riesgo específico y optimizado según tipo histológico.Introduction: Hodgkin lymphomas (HL and non Hodgkin lymphomas (NHL are frequently associated to acquired immunodeficiency syndrome in adults. Objective: To systematize the clinical features and histological characteristics of lymphomas in AIDS patients, its treatment and outcomes in our institution. Patients and Methods: Retrospective analysis of patients with HIV-associated lymphoma between January 2001 and December 2008 at the San Borja Arriarán Hospital complex. Results: Information was obtained from 30 patients with NHL and 7 with HL, with a median of 40 years. The majority of tumors were Burkitt lymphoma (47%, diffuse large cell lymphoma B-cell (37% and NHL of T lineage (10%. There was no CNS or cavities lymphoma. Almost all patients (86.7% with NHL were treated with CHOP chemotherapy, 57% of those receiving treatment had progression or relapse from complete remission. A rescue chemotherapy was indicated in 4 patients. 73% of patients receiving CHOP, complete 5 to 6 cycles of chemotherapy. The use of CHOP chemotherapy for the subgroup of patients with Burkitt lymphoma achieved low rates of complete remission and frequent relapse and disease progression, showing that CHOP was ineffective in improving survival, especially in high risk patients. We found statistically significant differences in survival according to IPIae (International prognostic Index age-adjusted. Conclusion: Non-Hodgkin lymphoma in HIV patients treated with chemotherapy protocols PAlNDA persists in our environment as a disease with a poor prognosis compared with findings in the international literature. The incorporation of new drugs of proven utility as rituximab and specific schemes chemotherapy could improve these results. The establishment of prognostic groups established by IPIae can guide clinical work for the use of chemotherapy tailored to their specific risk and optimized according to histologic

Álvaro Pizarro

2013-02-01

145

Tratamiento del linfoma cutáneo de células T con ligandos selectivos del receptor retinoide X: alteraciones endocrinológicas y metabólicas / Treatment of cutaneous T-cell lymphoma with retinoid receptor X-selective ligands: endocrine and metabolic disorders  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish Los ligandos selectivos del receptor retinoide X se utilizan actualmente en el tratamiento de estadios avanzados del linfoma cutáneo de células T resistentes a otros tratamientos sistémicos, siendo el bexaroteno el primer fármaco de este grupo aprobado en Europa. Se han descrito numerosos efectos ad [...] versos asociados a su utilización, entre los que destacan las alteraciones endocrino-metabólicas. Presentamos a 2 pacientes con linfoma cutáneo de células T, tratados con bexaroteno, que desarrollaron hipotiroidismo central y dislipemia de forma precoz tras su inicio. Se describen también la respuesta de estas alteraciones al tratamiento y su remisión completa tras suspender el bexaroteno. Abstract in english The retinoid X receptor-selective ligands has been used for advanced stages of cutaneous T-cell lymphoma refractory to previous systemic therapy, being bexarotene the first drug in this group approved in Europe. Multiple drug-related adverse events has been reported such as endocrine-metabolic disor [...] ders. We report 2 patients with cutaneous T-cell lymphoma, treated with bexarotene, that developed central hypothyroidism and dislipidaemia inmediately after the begining of this treatment. We also showed the successfully treatment response of these alterations and the total clinical remission after discontinuing the drug.

M. D., Avilés Pérez; V., Luna López; I., Rodríguez Nevado; D. de, Argila Fernández-Durán; J., Díaz Pérez de Madrid.

2007-12-01

146

Low-grade intravascular coagulation and reticuloendothelial function.  

Science.gov (United States)

The present study evaluated the influence of experimentally produced intravascular coagulation on reticuloendothelial (RE) stability. Intravascular coagulation was initiated by the intraperitoneal injection of bovine thrombin (500 U/100 g body wt) into male rats. RE function was evaluated by the vascular clearance of an 131I-labeled RE test colloid. Thrombin injection resulted in a transient (0.5-2 h) (P less than .05) depression of the phagocytic index (K) with maximal depression at 1 h postthrombin challenge. The phagocytic index was unaltered after injection of saline or heat-inactivated thrombin. Vascular clearance depression was primarily due to a 37% decrease (P less than .001) in hepatic Kupffer cell colloid clearance and was associated with increments in lung (82%) and marrow (100%) colloid localization with no splenic alterations. While intravascular coagulation was associated with decreased hepatic blood flow at 30 min and 120 min, sinusoidal flow was normal during maximum RE impairment at 60 min. The in vivo clearance depression was not reflected as an intrinsic Kupffer cellular deficit when evaluated in an in vitro system. The results indicate a transient RE dysfunction during intravascular coagulation, the mechanism of which remains to be elucidated. PMID:645871

Kaplan, J E; Saba, T M

1978-04-01

147

Intravascular large B-cell lymphoma of the breast.  

Science.gov (United States)

The case of an 80-year-old woman with symmetrical breast engorgement and nonspecific systemic symptoms progressively developing over 3 months and confirmed on surgical biopsy to be due to an intravascular large B-cell lymphoma (ILBCL) is presented. To our knowledge, ILBCL has never been reported in the breast before and its mammography and ultrasound appearances are described. PMID:15695087

Monteiro, M; Duarte, I; Cabeçadas, J; Orvalho, M L

2005-02-01

148

Linfoma pulmonar primario de bajo grado no BALT / Non-BALT low grade primary lung lymphomas  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish El linfoma pulmonar primario (LPP) es una patología infrecuente que engloba un amplio espectro de entidades clínico-patológicas, la gran mayoría de las cuales corresponde a linfomas de baja malignidad tipo BALT (linfoma asociado al tejido linfoide bronquial). Presentamos el caso de una paciente con [...] un linfoma linfocítico B de células pequeñas, primario de pulmón, de bajo grado de malignidad, con la excepcionalidad de no ser encuadrable dentro del subtipo BALT. Discutimos aquí el diagnóstico diferencial histológico entre ambos tipos de linfomas, así como los hallazgos clínico-radiológicos, el pronóstico y la respuesta al tratamiento. Abstract in english Primary lung lymphomas show a broad clinical and cytological spectrum. The most common histological subtypes are low-grade lymphomas from bronchus-associated lymphoid tissue (BALT). We report a case of non-BALT low-grade lung lymphoma: a primary small B-cell lymphocytic lymphoma. We discuss the hist [...] ological differential diagnosis, the clinical and radiological findings, prognosis and response to treatment.

F., Ferrer Marín; M. J., Avilés Inglés.

149

Linfoma renal: espectro de imagens na tomografia computadorizada Renal lymphoma: spectrum of computed tomography findings  

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Full Text Available O acometimento renal no linfoma é raro, uma vez que o rim não possui tecido linfóide. O envolvimento secundário é mais freqüente, ocorrendo em até um terço das autópsias dos portadores de linfoma. Alguns autores acreditam que esta seja a única forma de acometimento renal, questionando a existência do linfoma primário. O linfoma renal representaria metástases hematogênicas ou invasão direta do tumor ocorrendo no espaço perirrenal. A partir destes tipos de envolvimento decorrem as formas de apresentação do linfoma renal: múltiplos nódulos, massa solitária, invasão renal por doença retroperitoneal contígua, doença perirrenal e infiltração difusa. Neste trabalho são discutidas e apresentadas imagens destas diferentes formas de acometimento.Isolated renal lymphoma is rare due to the absence of lymphoid tissue in kidneys. Secondary involvement occurs more frequently and is reported in up to 1/3 of the autopsies of patients who died from lymphoma. Some authors believe this is actually the only existing form of renal lymphoma. The involvement of the kidney by lymphoma would occur through hematogenic metastasis or direct tumor invasion of the perirenal space. These different types of involvement determine the several forms of renal lymphoma presentation: multiple nodules, solitary mass, renal invasion from contiguous retroperitoneal disease, perirenal disease and diffuse infiltration. In this study the imaging findings features of the different forms of involvement are presented and discussed.

Carol Pontes de Miranda Maranhão

2005-04-01

150

Linfoma renal: espectro de imagens na tomografia computadorizada / Renal lymphoma: spectrum of computed tomography findings  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese O acometimento renal no linfoma é raro, uma vez que o rim não possui tecido linfóide. O envolvimento secundário é mais freqüente, ocorrendo em até um terço das autópsias dos portadores de linfoma. Alguns autores acreditam que esta seja a única forma de acometimento renal, questionando a existência d [...] o linfoma primário. O linfoma renal representaria metástases hematogênicas ou invasão direta do tumor ocorrendo no espaço perirrenal. A partir destes tipos de envolvimento decorrem as formas de apresentação do linfoma renal: múltiplos nódulos, massa solitária, invasão renal por doença retroperitoneal contígua, doença perirrenal e infiltração difusa. Neste trabalho são discutidas e apresentadas imagens destas diferentes formas de acometimento. Abstract in english Isolated renal lymphoma is rare due to the absence of lymphoid tissue in kidneys. Secondary involvement occurs more frequently and is reported in up to 1/3 of the autopsies of patients who died from lymphoma. Some authors believe this is actually the only existing form of renal lymphoma. The involve [...] ment of the kidney by lymphoma would occur through hematogenic metastasis or direct tumor invasion of the perirenal space. These different types of involvement determine the several forms of renal lymphoma presentation: multiple nodules, solitary mass, renal invasion from contiguous retroperitoneal disease, perirenal disease and diffuse infiltration. In this study the imaging findings features of the different forms of involvement are presented and discussed.

Carol Pontes de Miranda, Maranhão; Tufik, Bauab Jr.

2005-04-01

151

Linfomatosis intravascular: Descripción de tres casos / Intravascular lymphomatosis: A report of three cases  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish La linfomatosis intravascular (LIV) es una neoplasia poco frecuente caracterizada por la proliferación de células linfoides atípicas en la luz de pequeños vasos (vénulas, capilares y arteriolas). La sintomatología está causada por fénomenos trombóticos debido a la oclusión de los vasos por células t [...] umorales. Los órganos más afectados son el sistema nervioso y la piel, aunque puede estar involucrado cualquier otro sistema, sin afectación de los tejidos linfoides. Presentamos tres casos de LIV: el primero se trata de un varón de 57 años que debuta con demencia y síntomas neurológicos; un segundo caso en un paciente de 69 años con manifestaciones predominantemente pulmonares (tos, disnea y fiebre) y una mujer con fiebre de origen desconocido (FOD) y síndrome inflamatorio sistémico. Dada la ausencia de signos específicos de esta entidad multiorgánica con evolución rápidamente progresiva, su diagnóstico es postmorten en todos nuestros casos. Para su confirmación se precisó de biopsia de uno de los órganos afectados. En conclusión, consideramos la necesidad de plantear el diagnóstico diferencial con el síndrome confusional agudo, demencia o síndromes neurológicos de etiología no filiada, vasculitis, neoplasias ocultas, fiebre de origen desconocido o infecciones con afectación multiorgánica y valores muy elevados de LDH. Abstract in english Intravascular lymphomatosis (IVL) is a rare malignancy characterized by a proliferation of atypical lymphoid cells occluding small blood vessels (venules, capillaries and small arteries). The symptoms are caused by embolims due to massive proliferation. Nervous system and skin are the most common si [...] tes of involvement but all organs may be involved, although it is typified by the absence of malignant cells in lymphoid tissues. We describe three cases of IVL: first patient was a 57 years old man with rapidly progressive dementia and neurological involvements and second case of a 69 years old man hospitalised with predominant symptoms in the lung (cough, dyspnea and fever), and a woman presenting as fever of unknown origin (FUO) with systemic inflammatory response syndrome. In all cases that we reported have been diagnosed post-morten because of rapid progression of a multisystem disease and the absence of pathognomonic clinical manifestations. Diagnosis can be made using biopsy of one of the involved organs. In conclusion, we propose that IVL should be inclucled in the differential diagnosis of acute confusional state, dementia or other unexplained neurological manifestations, fever of unknown origin, vasculitis, occult neoplasia or infections with signs of a systemic disease and marked elevation of serum lactate dehydrogenase (LDH).

M. J., Menéndez Calderón; M. E., Seguí Riesco; M., Argüelles; J., Nuño Mateo.

2005-01-01

152

Características imaginológicas del linfoma primario de recto: reporte de un caso y revisión de la literatura  

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Full Text Available El linfoma primario de recto es un tumor intestinal, poco frecuente, que está constituido, principalmente, por el tipo no Hodgkin extraganglionar y corresponde de 0,2% a 0,6% de todos los tumores de colon y recto. Se presenta el caso de una mujer de 79 años que consultó por una masa en recto de varios meses de evolución y rectorragia crónica. Se le tomó una biopsia, cuyo reporte histopatológico fue indicativo de linfoma no Hodgkin. El linfoma no Hodgkin de recto es un tumor raro, con pobre pronóstico, cuyo pilar de tratamiento es la cirugía. A continuación, se presenta el caso y una breve revisión de las características clínicas e imaginológicas de esta neoplasia poco frecuente.

LIDA MILENA APONTE

2010-01-01

153

Linfoma do sistema nervoso central: ensaio iconográfico / Central nervous system lymphoma: iconographic essay  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Ilustramos este ensaio iconográfico de linfoma do sistema nervoso central com imagens de ressonância magnética obtidas em nosso serviço nos últimos 13 anos e discutimos algumas das principais características radiológicas deste tipo de linfoma, primário e secundário. O linfoma sistema nervoso central [...] é um tumor relativamente infrequente, mas alguns achados na ressonância magnética podem sugerir este diagnóstico. Abstract in english The authors illustrate the present pictorial essay about central nervous system lymphoma with magnetic resonance images obtained in their institution over the past 13 years. Some of the main radiological findings in primary and secondary presentations of this type of lymphoma are discussed. Central [...] nervous system lymphoma is a relatively uncommon tumor, but magnetic resonance imaging findings may suggest the diagnosis.

Fabiano, Reis; Ricardo, Schwingel; Felipe Barjud Pereira do, Nascimento.

2013-04-01

154

Linfoma do sistema nervoso central: ensaio iconográfico / Central nervous system lymphoma: iconographic essay  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Ilustramos este ensaio iconográfico de linfoma do sistema nervoso central com imagens de ressonância magnética obtidas em nosso serviço nos últimos 13 anos e discutimos algumas das principais características radiológicas deste tipo de linfoma, primário e secundário. O linfoma sistema nervoso central [...] é um tumor relativamente infrequente, mas alguns achados na ressonância magnética podem sugerir este diagnóstico. Abstract in english The authors illustrate the present pictorial essay about central nervous system lymphoma with magnetic resonance images obtained in their institution over the past 13 years. Some of the main radiological findings in primary and secondary presentations of this type of lymphoma are discussed. Central [...] nervous system lymphoma is a relatively uncommon tumor, but magnetic resonance imaging findings may suggest the diagnosis.

Fabiano, Reis; Ricardo, Schwingel; Felipe Barjud Pereira do, Nascimento.

155

Herpes hipertrófico perianal tratado eficazmente com imiquimod  

Digital Repository Infrastructure Vision for European Research (DRIVER)

A infecção pelo vírus herpes simples tipo 2 (HSV-2) é frequente em pacientes infetados pelo vírus de imunodeficiência adquirida (VIH). Nestes casos, o herpes genital pode ter uma apresentação clínica atípica. As variantes hipertróficas e vegetantes são pouco habituais. Os autores relatam um caso de herpes hipertrófico perianal em paciente infetada pelo VIH, com resposta insatisfatória ao aciclovir e valaciclovir, tratado eficazmente com imiquimod tópico. O herpes genital ...

Lestre, S.; Joa?o, A.; Carvalho, C.; Serra?o, W.

2011-01-01

156

Classificação dos linfomas não-Hodgkin: estudo morfológico e imunoistoquímico de 145 casos  

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Full Text Available A classificação dos linfomas não-Hodgkin tem sido, ao longo dos últimos trinta anos, motivo de controvérsia. Várias classificações têm sido propostas em busca de um consenso entre patologistas e clínicos. Este trabalho teve como objetivo analisar criticamente três destas classificações através do estudo retrospectivo de 145 casos de linfomas primários de gânglio linfático selecionados do Serviço de Anatomia Patológica do Hospital Universitário Clementino Fraga Filho, entre 1979 e 1995. Os casos revistos foram classificados pelas propostas da Working Formulation, de Kiel e da Real. Testes imunoistoquímicos com os anticorpos anti-CD45, anti-CD20, anti-CD45RO e anti-CD30 foram realizados. Cento e sete casos (73,7% apresentaram fenótipo B; 33 casos (22,7%, fenótipo T; e quatro casos foram nulos (linfoma anaplásico de grandes células. Foi possível prever o fenótipo pela morfologia em 89,4% dos casos. Os linfomas de alto grau predominaram (59,2%, sendo o linfoma centroblástico o de maior freqüência (31,7% . Os linfomas foliculares representaram 29 casos (20%, com maior incidência dos de grandes células (31% do que dos de pequenas células (27,5%. Quando comparadas as três classificações, observamos que determinados grupos da Working Formulation abrigam múltiplas entidades. Isto se deve ao fato de a classificação da Working Formulation ser baseada somente em achados morfológicos e, por isso, deve ter seu uso desaconselhado. Já a classificação de Kiel e a da Real devem ter o seu emprego estimulado, pois apresentam, além de uma boa análise histopatológica, um estudo imunológico que define entidades biológicas correlacionando-se, quando possível, com a célula de origem.

Milito Cristiane Bedran

2002-01-01

157

Reuso do efluente tratado na indústria curtidora  

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Full Text Available Com o objetivo de avaliar a possibilidade de reúso do efluente líquido tratado de uma indústria curtidora, foi realizada esta pesquisa. O procedimento experimental comparou a produção de couros confeccionados com água potável, extraída de poçosartesianos, com couros produzidos a partir do efluente líquido final tratado. Para alcançar este objetivo, foram realizados testes físicose químicos através de análises em laboratório (análises químicas e de resistências físicas e avaliações organolépticas executadas porprofissionais do setor de couro (quanto a cor, firmeza de flor, enchimento e toque. A avaliação analítica e a das característicasorganolépticas não indicam diferenças representativas quando comparadas aos padrões de referência da ABNT de couros produzidos,permitindo, assim, concluir que o reúso de efluente tratado não altera a aparência dos artigos de couro.Abstract This research was carried out to evaluate the possibility of reuse of a tannery treated effluent. The experimental procedure compared the production of leather made by the use of drinking water, extracted from artesian wells, to leather produced by the use of the final treated liquid effluent. In order to achieve this goal, physic-chemical tests were carried out in laboratory (chemical and physical resistance analysis and leather industry professionals performed organoleptic evaluations (for color, grain firmness, filling and touch. The analytical evaluation and the organoleptic properties evaluation do not indicate a statistically significant difference when compared to ABNT reference standards of produced leathers, what allows the researchers to conclude that the reuse of treated effluent does not change the appearance of leather goods.

Karl Heinz Luersen

2012-01-01

158

Linfoma mediastinal en una lactante / Mediastinal lymphoma in an infant  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Se presenta el caso clínico de una lactante de 17 meses, remitida al Hospital Infantil Sur de Santiago de Cuba, en fase terminal, desde el Hospital Pediátrico de Palma Soriano, donde había permanecido ingresada durante 14 días por neumonía grave. Inicialmente se planteó la posibilidad de un proceso [...] séptico de origen tuberculoso o tumoral. En todo momento, la niña evolucionó desfavorablemente hasta fallecer. Los hallazgos anatomopatológicos confirmaron la presencia de un linfoma linfoblástico agudo del mediastino, con infiltración linfomatosa del saco pericardio, ambas pleuras, parénquima pulmonar, ganglios aorticoabdominales y ambos riñones. Abstract in english The clinical case of a 17-months infant is reported, who was referred to the Southern Children Hospital of Santiago de Cuba, in terminal period, from Palma Soriano Children Hospital, where she was hospitalized during 14 days due to severe pneumonia. Initially it was raised the possibility of a tumor [...] or tuberculous septic process. All the time she made a poor progress until death. Pathological findings confirmed the presence of acute lymphoblastic lymphoma of the mediastinum with lymphomatous infiltration of the pericardial sac, pleurae, lung parenchyma, aorticoabdominal lymph nodes and kidneys.

Delfín, Chaveco Bautista; Belkis E, Babié Reyes; Flora I, Frómeta Luna; Mercedes F, Ronda León; Alina, Rodríguez Griñán.

2010-07-19

159

Linfoma mediastinal en una lactante Mediastinal lymphoma in an infant  

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Full Text Available Se presenta el caso clínico de una lactante de 17 meses, remitida al Hospital Infantil Sur de Santiago de Cuba, en fase terminal, desde el Hospital Pediátrico de Palma Soriano, donde había permanecido ingresada durante 14 días por neumonía grave. Inicialmente se planteó la posibilidad de un proceso séptico de origen tuberculoso o tumoral. En todo momento, la niña evolucionó desfavorablemente hasta fallecer. Los hallazgos anatomopatológicos confirmaron la presencia de un linfoma linfoblástico agudo del mediastino, con infiltración linfomatosa del saco pericardio, ambas pleuras, parénquima pulmonar, ganglios aorticoabdominales y ambos riñones.The clinical case of a 17-months infant is reported, who was referred to the Southern Children Hospital of Santiago de Cuba, in terminal period, from Palma Soriano Children Hospital, where she was hospitalized during 14 days due to severe pneumonia. Initially it was raised the possibility of a tumor or tuberculous septic process. All the time she made a poor progress until death. Pathological findings confirmed the presence of acute lymphoblastic lymphoma of the mediastinum with lymphomatous infiltration of the pericardial sac, pleurae, lung parenchyma, aorticoabdominal lymph nodes and kidneys.

Delfín Chaveco Bautista

160

Recidiva tardia de linfoma da zona marginal Late relapse of marginal zone lymphoma  

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Full Text Available O linfoma de zona marginal é um linfoma de baixo grau com curso clínico indolente e potencial de recidiva.1,2 Apresentamos um caso de recidiva tardia após 25 anos de aparente remissão completa, levantando a possibilidade de recidiva de doença preexistente ou desenvolvimento de novo clone neoplásico.Marginal zone lymphoma is a low grade lymphoma with an indolent course and chance to relapse. We present a case of a patient who suffered relapse after 25 years of apparently complete remission of a low-grade non-Hodgkin lymphoma.

Talita M. B.S. Rocha

2009-01-01

 
 
 
 
161

Search of intravascular hemolysis in patients with the cutaneous form of loxoscelism Pesquisa de hemólise intravascular na forma cutânea de loxoscelismo  

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Full Text Available Haptoglobin assay, a highly sensitive method to detect intravascular hemolysis was carried out in the sera of 19 patients referred to Hospital Vital Brazil with the cutaneous form of loxoscelism in order to investigate the occurrence of mild intravascular hemolysis. Data from this series did not show decreased levels haptoglobin, ruling out intravascular hemolysis in these patients with cutaneous form of loxoscelism.Dezenove pacientes que apresentaram a forma clínica cutânea do loxoscelismo foram investigados com o propósito de pesquisar hemólise intravascular sub-clínica, lançando mão da dosagem de haptoglobina, um método altamente sensível que permite detectar discreta presença de hemólise intravascular. Não foi encontrada diminuição de haptoglobina, o que descarta uma ação hemolítica do veneno da Loxosceles nestes pacientes.

Pasquale Morena

1994-04-01

162

Intravascular ultrasound of the portal vein--normal anatomy.  

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The purpose of this study was to evaluate the appearance of the normal portal vein with intravascular ultrasound. The portal vein was studied in 10 patients with colorectal carcinoma without known liver or pancreatic disease. For the intravascular portovenous examination, a 2.0-mm, 20-MHz ultrasound catheter was used. The field of view was 30 mm. The wall of the portal vein appeared as a single hyperechoic layer 0.5 to 0.8 mm in thickness. Normal structures adjacent to the portal vein, such as the common bile duct, the hepatic artery or small lymph nodes, were clearly separated from the lumen of the portal vein by the wall of the vein together with some periportal fat. In most cases the parenchyma of the pancreas could be separated from the wall of the vein. PMID:7619617

Hannesson, P H; Stridbeck, H; Lundstedt, C; Andrén-Sandberg, A; Ihse, I

1995-07-01

163

Nosocomial blood-borne infection secondary to intravascular devices.  

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A total of 143 patients with 159 episodes of intravascular device, blood-borne infection were studied. All infections were confirmed by the same organism being recovered from blood culture and by semiquantitative culture of the catheter tip. Sites of infection included the peripheral venous line (n = 72), central catheter (n = 49), arterial line (n = 18), subclavian dialysis catheter (n = 12), Swan-Ganz catheter (n = 4), Broviac catheter (n = 3), and transvenous pacemaker wires (n = 1). Staphylococcus aureus (n = 78) and Staphylococcus epidermidis (n = 33) predominated as pathogens. Excessive length of catheterization was implicated as directly responsible for this complication in patients with peripheral intravenous and arterial lines. Nosocomial staphylococcal bacteremia must be considered secondary to an indwelling intravascular device until proven otherwise. Appropriate therapy requires removal of the catheters, excision of the vein if suppuration or persistent bacteremia is identified, and specific antibiotic therapy. PMID:8135318

Fry, D E; Fry, R V; Borzotta, A P

1994-02-01

164

Intravascular Brachytherapy. A model for the calculation of the dose.  

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Full Text Available In this study we present the radiation dose distribution for a theoretical model with Montecarlo simulation, and based on an experimental model developed for the study of the prevention of restenosis post-angioplasty employing intravascular brachytherapy. In the experimental in vivo model, the atherosclerotic plaques were induced in femoral arteries of male New Zealand rabbits through surgical intervention and later administration of cholesterol enriched diet. For the intravascular irradiation we employed a 32P source contained within the balloon used for the angioplasty. The radiation dose distributions were calculated using the Monte Carlo code MCNP4B according to a segment of a simulated artery. We studied the radiation dose distribution in the axial and radial directions for different thickness of the atherosclerotic plaques. The results will be correlated with the biologic effects observed by means of histological analysis of the irradiated arteries.

Pirchio, Rosana.

2002-01-01

165

Integrated intravascular optical coherence tomography ultrasound imaging system  

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We report on a dual-modality optical coherence tomography (OCT) ultrasound (US) system for intravascular imaging. To the best of our knowledge, we have developed the first integrated OCT-US probe that combines OCT optical components with an US transducer. The OCT optical components mainly consist of a single-mode fiber, a gradient index lens for light-beam focusing, and a right-angled prism for reflecting light into biological tissue. A 40-MHz piezoelectric transducer (PZT-5H) side-viewing US transducer was fabricated to obtain the US image. These components were integrated into a single probe, enabling both OCT and US imaging at the same time. In vitro OCT and ultrasound images of a rabbit aorta were obtained using this dual-modality imaging system. This study demonstrates the feasibility of an OCT-US system for intravascular imaging, which is expected to have a prominent impact on early detection and characterization of atherosclerosis. PMID:20210424

Yin, Jiechen; Yang, Hao-Chung; Li, Xiang; Zhang, Jun; Zhou, Qifa; Hu, Changhong; Shung, K. Kirk; Chen, Zhongping

2010-01-01

166

Intravascular photoacoustic tomography for characterization of atherosclerotic lipid and inflammation  

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Photoacoustic imaging is a fast growing imaging technology depending on its high optical resolution of optics while taking the advantage of the high penetration depth of ultrasound. In this paper, we demonstrate the new progress in the photoacoustic imaging. Atherosclerosis is characterized by a progressive build-up of lipid in the arterial wall, which is known as plaque. Histological studies demonstrate that the primary cause of acute cardiovascular events is the rupture of atherosclerotic plaques. Lipid and inflammation within the plaque are related to influence the propensity of plaques to disrupt. Photoacoustic intravascular tomography (IVPAT) holds a great advantage in providing comprehensive morphological and functional information of plaques. Lipid relative concentration maps of atherosclerotic aorta were obtained and compared with histology. Furthermore, by selectively targeting the intravascular inflammatory cytokines, IVPAT is also capable of mapping the inflamed area and determining the degree of inflammation.

Zhang, Jian; Qin, Huan; Shi, Yujiao; Yang, Sihua; Xing, Da

2014-09-01

167

Intravascular magnetic resonance imaging using a loopless catheter antenna.  

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Recently, intravascular catheter probes have been developed to increase signal-to-noise ratio (SNR) for MR imaging of blood vessels. Miniaturization of these catheter probes without degrading their performances is very critical in imaging small vessels such as coronary arteries. Catheter coils have a loop incorporated in their structure and have limitations in physical dimensions and electromagnetic properties. The use of a loopless intravascular catheter antenna is proposed to overcome these problems. The catheter antenna is essentially a dipole, which makes a very thin diameter possible, and its electronic circuitry can be placed outside the blood vessels without performance degradation. The theoretical foundation for the design and operation of the catheter antenna is presented. Several catheter antennae, as small as 1.5 French, were constructed and tested on phantoms and rabbits with great success. The catheter antenna has a simple structure and is easy to design, implement, and operate. PMID:8978639

Ocali, O; Atalar, E

1997-01-01

168

SEPSIS-ASSOCIATED DISSEMINATED INTRAVASCULAR COAGULATION AND THROMBOEMBOLIC DISEASE  

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Sepsis is almost invariably associated with haemostatic abnormalities ranging from subclinical activation of blood coagulation (hypercoagulability), which may contribute to localized venous thromboembolism, to acute disseminated intravascular coagulation (DIC), characterized by massive thrombin format...

2010-01-01

169

Renal denervation by intravascular ultrasound: Preliminary in vivo study  

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Ultrasound denervation has recently become a subject of intense research in connection with the treatment of complex medical conditions including neurological conditions, development of pain management, reproduction of skin sensation, neuropathic pain and spasticity. The objective of this study is to investigate the use of intravascular ultrasound to produce nerve damage in renal sympathetic nerves without significant injury to the renal artery. This technique may potentially be used to treat various medical conditions, such as hypertension. The study was approved by the Institutional Animal Care and Use Committee. Ultrasound was applied to renal nerves of the swine model for histopathological evaluation. Therapeutic ultrasound energy was delivered circumferentially by an intravascular catheter maneuvered into the renal arteries. Fluoroscopic imaging was conducted pre-and post-ultrasound treatment. Animals were recovered and euthanized up to 30 hours post procedure, followed by necropsy and tissue sample collection. Histopathological examination showed evidence of extensive damage to renal nerves, characterized by nuclear pyknosis, hyalinization of stroma and multifocal hemorrhages, with little or no damage to renal arteries. This study demonstrates the feasibility of intravascular ultrasound as a minimally invasive renal denervation technique. Further studies are necessary to evaluate the long-term safety and efficacy of this technique and its related clinical significance.

Sinelnikov, Yegor; McClain, Steve; Zou, Yong; Smith, David; Warnking, Reinhard

2012-10-01

170

Asian-variant intravascular lymphoma in the African race  

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Full Text Available Intravascular large B-cell lymphoma (IVLBCL is an exceptionally rare form of non- Hodgkin lymphoma (NHL distinguished by the preferential growth of neoplastic cells within blood vessel lumen. Challenging to detect and deemed disseminated at diagnosis, this condition is characterized by a highly aggressive, inconspicuous course with a high mortality rate. We describe the case of a 48 year-old African-American female presenting with a two month history of low-grade fevers and malaise. Laboratory data was notable for anemia, thrombocytopenia, elevated liver function tests, and hematuria. An extensive workup for infectious, rheumatologic and malignant causes was negative. Her symptoms progressed and within two weeks, she was admitted for disseminated intravascular coagulation (DIC. Her course was complicated by diffuse pulmonary hemorrhage and ultimately, care was withdrawn. Autopsy identified widespread CD-20 positive intravascular large B-cell lymphoma with significant hepatosplenic involvement, characteristic of the Asian variant IVLBCL. This case uniquely highlights development of the Asian variant IVLBVL in a previously undescribed race. Identified by its intraluminal vascular growth pattern, IVLBCL generally spares lymphatic channels. Diagnosis and differentiation of this condition from other hematological malignancies via skin, visceral and bone marrow biopsy is imperative as anthracycline-containing chemotherapies may significantly improve clinical outcomes. This article outlines the common presentation, natural course, and treatment options of IVLBCL, along with the histopathology, immunohistochemistry, and chromosomal aberrations common to this condition.

Brian Palen

2012-01-01

171

Cutaneous collagenous vasculopathy associated with intravascular occlusive fibrin thrombi.  

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Cutaneous collagenous vasculopathy (CCV) is a rare cutaneous microangiopathy that clinically resembles generalized essential telangiectasia with only 12 cases reported to date. The perivascular fibrosis is thought to be due to production of abnormal collagen by veil cells in the outer vessel walls as a result of unknown factors. This report is of an 84-year-old male with progressive telangiectasia. Biopsies showed characteristic features of CCV. In addition, there were multiple intravascular fibrin thrombi, some organizing and associated with endothelial cell hyperplasia with recanalization reminiscent of glomeruloid bodies and simulating reactive angioendotheliomatosis (RAE). Histochemically and ultrastructurally fibrin was noted within the vessel walls integrating into the fibrous tissue around the vessels; however, the patient had no evidence of coagulation disorder, cryoglobulinemia or cold agglutinemia. Immunofluorescence showed fibrinogen within the vessel walls but no immunoglobulins or C3. As well, there were minimal inflammatory cells. This suggests pauci-inflammatory injury to the endothelial cells by unknown angiogenic factors causing local intravascular fibrin thrombi with fibrin leaking and incorporating into the vessel walls, eventually leading to reparative perivascular fibrosis. This case suggests that some cases of CCV are related to a primary local intravascular occlusive thrombotic microangiopathy. However, the primary triggering factor causing the endothelial cell damage has yet to be elucidated. PMID:24350781

Salama, Samih; Chorneyko, Kathy; Belovic, Brian

2014-04-01

172

Linfoma tonsilar em crianças com assimetria tonsilar / Tonsillar lymphoma in children with unilateral tonsillar enlargement / Linfoma tonsilar en niños con asimetría tonsilar  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese OBJETIVO: Demonstrar a importância do exame físico com ênfase nas alterações das tonsilas palatinas (TP) e na anamnese direcionada para a identificação precoce de pacientes com linfoma de TP. DESCRIÇÃO DO CASO: Caso 1 - Menina de cinco anos com voz abafada, observada pela mãe, e "sensação de algo es [...] tranho na garganta" há duas semanas. Foi atendida em outro serviço no início do quadro, sendo medicada com amoxicilina, sem melhora. Apresentava aumento importante da TP direita com superfície lisa e ausência de criptas. Após cirurgia, foi confirmado o diagnóstico de linfoma não Hodgkin (LNH). Na investigação também foi identificado acometimento dos linfonodos mesentéricos pelo linfoma. Caso 2 - Menina de 11 anos procurou o pronto-socorro para investigar nódulo em TP esquerda, indolor, de crescimento progressivo há um ano, sem outras queixas. Já havia passado por consultas médicas anteriores, não tendo sido valorizada a queixa da paciente. A TP esquerda encontrava-se aumentada, ultrapassando a linha média e com nódulo no polo superior. Também foi diagnosticado LNH após exame anatomopatológico. COMENTÁRIOS: Um exame minucioso da cavidade oral e do pescoço é essencial para identificar alterações suspeitas de linfoma tonsilar. Pacientes com assimetria tonsilar e outros achados sugestivos de malignidade devem ser submetidos à tonsilectomia. Abstract in spanish OBJETIVO: Demostrar la importancia de un examen físico con énfasis en las alteraciones de las tonsilas palatinas (TP) y en la anamnesis dirigida a la identificación temprana de pacientes con linfoma de TP. DESCRIPCIÓN DEL CASO: Caso 1 - Niña de cinco años, con voz velada, observada por la madre, y « [...] sensación de algo extraño en la garganta» hace dos semanas. Fue atendida en otro servicio en el inicio del cuadro, siendo medicada con amoxicilina, sin mejora. Presentaba aumento importante de la TP derecha con superficie lisa y ausencia de criptas. Después de la cirugía, se confirmó el diagnóstico de linfoma no Hodgkin (LNH). En la investigación también se identificó acometimiento de los nodos linfáticos mesentéricos por el linfoma. Caso 2 - Muchacha de 11 años buscó al servicio de urgencia para investigar nódulo en TP izquierda, indolora, de crecimiento progresivo hace un año, sin otras quejas. Ya había pasado por consultas médicas anteriores, no habiendo sido valorizada la queja de la paciente. La TP izquierda se encontraba aumentada, sobrepasando la línea media y con nódulo en el polo superior de esa. También se diagnosticó LNH después de examen anatomopatológico. COMENTARIOS: Un examen minucioso de la cavidad oral y del cuello es esencial para identificar alteraciones sospechosas de linfoma tonsilar. Pacientes con asimetría tonsilar y otros hallazgos sugestivos de malignidad deben ser sometidos a tonsilectomía. Abstract in english OBJECTIVE: To demonstrate the importance of a medical examination with emphasis on changes of the palatine tonsils (PT) and proper anamnesis to early identify patients with tonsillar lymphoma. CASE DESCRIPTION: Case 1 - 5-year-old girl with a muffled voice noted by her mother and a report of "feelin [...] g a strange sensation in the throat" for two weeks. She was previously treated in another service at the beginning of the symptoms with amoxicillin without improvement. An important increase in the right PT was noted, with smooth surface and absence of crypts. The diagnosis of non-Hodgkin lymphoma (NHL) was confirmed after surgery. On further investigation, positive mesenteric lymph nodes were noted. Case 2 - 11-year-old girl came to the emergency service to investigate a painless nodule in the left palatine tonsil with progressive growth for one year, without other complaints. She had previously undergone other medical consultations, but no importance was given to the patient's complaint. Oroscopy showed that the left PT was increased crossing the midline and with a nodule in the upp

Alexandre Caixeta, Guimarães; Guilherme Machado de, Carvalho; Reinaldo Jordão, Gusmão.

2012-06-01

173

Linfoma tonsilar em crianças com assimetria tonsilar / Tonsillar lymphoma in children with unilateral tonsillar enlargement / Linfoma tonsilar en niños con asimetría tonsilar  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese OBJETIVO: Demonstrar a importância do exame físico com ênfase nas alterações das tonsilas palatinas (TP) e na anamnese direcionada para a identificação precoce de pacientes com linfoma de TP. DESCRIÇÃO DO CASO: Caso 1 - Menina de cinco anos com voz abafada, observada pela mãe, e "sensação de algo es [...] tranho na garganta" há duas semanas. Foi atendida em outro serviço no início do quadro, sendo medicada com amoxicilina, sem melhora. Apresentava aumento importante da TP direita com superfície lisa e ausência de criptas. Após cirurgia, foi confirmado o diagnóstico de linfoma não Hodgkin (LNH). Na investigação também foi identificado acometimento dos linfonodos mesentéricos pelo linfoma. Caso 2 - Menina de 11 anos procurou o pronto-socorro para investigar nódulo em TP esquerda, indolor, de crescimento progressivo há um ano, sem outras queixas. Já havia passado por consultas médicas anteriores, não tendo sido valorizada a queixa da paciente. A TP esquerda encontrava-se aumentada, ultrapassando a linha média e com nódulo no polo superior. Também foi diagnosticado LNH após exame anatomopatológico. COMENTÁRIOS: Um exame minucioso da cavidade oral e do pescoço é essencial para identificar alterações suspeitas de linfoma tonsilar. Pacientes com assimetria tonsilar e outros achados sugestivos de malignidade devem ser submetidos à tonsilectomia. Abstract in spanish OBJETIVO: Demostrar la importancia de un examen físico con énfasis en las alteraciones de las tonsilas palatinas (TP) y en la anamnesis dirigida a la identificación temprana de pacientes con linfoma de TP. DESCRIPCIÓN DEL CASO: Caso 1 - Niña de cinco años, con voz velada, observada por la madre, y « [...] sensación de algo extraño en la garganta» hace dos semanas. Fue atendida en otro servicio en el inicio del cuadro, siendo medicada con amoxicilina, sin mejora. Presentaba aumento importante de la TP derecha con superficie lisa y ausencia de criptas. Después de la cirugía, se confirmó el diagnóstico de linfoma no Hodgkin (LNH). En la investigación también se identificó acometimiento de los nodos linfáticos mesentéricos por el linfoma. Caso 2 - Muchacha de 11 años buscó al servicio de urgencia para investigar nódulo en TP izquierda, indolora, de crecimiento progresivo hace un año, sin otras quejas. Ya había pasado por consultas médicas anteriores, no habiendo sido valorizada la queja de la paciente. La TP izquierda se encontraba aumentada, sobrepasando la línea media y con nódulo en el polo superior de esa. También se diagnosticó LNH después de examen anatomopatológico. COMENTARIOS: Un examen minucioso de la cavidad oral y del cuello es esencial para identificar alteraciones sospechosas de linfoma tonsilar. Pacientes con asimetría tonsilar y otros hallazgos sugestivos de malignidad deben ser sometidos a tonsilectomía. Abstract in english OBJECTIVE: To demonstrate the importance of a medical examination with emphasis on changes of the palatine tonsils (PT) and proper anamnesis to early identify patients with tonsillar lymphoma. CASE DESCRIPTION: Case 1 - 5-year-old girl with a muffled voice noted by her mother and a report of "feelin [...] g a strange sensation in the throat" for two weeks. She was previously treated in another service at the beginning of the symptoms with amoxicillin without improvement. An important increase in the right PT was noted, with smooth surface and absence of crypts. The diagnosis of non-Hodgkin lymphoma (NHL) was confirmed after surgery. On further investigation, positive mesenteric lymph nodes were noted. Case 2 - 11-year-old girl came to the emergency service to investigate a painless nodule in the left palatine tonsil with progressive growth for one year, without other complaints. She had previously undergone other medical consultations, but no importance was given to the patient's complaint. Oroscopy showed that the left PT was increased crossing the midline and with a nodule in the upp

Alexandre Caixeta, Guimarães; Guilherme Machado de, Carvalho; Reinaldo Jordão, Gusmão.

174

Taquicardia ventricular associada com linfoma não-Hodgkin Taquicardia ventricular asociada con linfoma no Hodgkin Ventricular tachycardia associated with non-Hodgkin's lymphoma  

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Full Text Available Linfoma não-Hodgkin sistêmico pode afetar o miocárdio, particularmente em pacientes imunocomprometidos. Quando presentes, sinais e sintomas são geralmente inespecíficos, tornando o diagnóstico de envolvimento cardíaco muito difícil antes da autópsia. Arritmias ventriculares também são pouco usuais nesse cenário. Descrevemos um caso de linfoma não-Hodgkin miocárdico secundário, que se apresentou com taquicardia ventricular monomórfica sustentada e espessamento do septo interventricular basal. Completa remissão das lesões miocárdicas foi observada após o término da quimioterapia de segunda linha, sem recorrências posteriores de arritmias em oito meses.Linfoma no Hodgkin sistémico puede afectar el miocardio, particularmente en pacientes inmunocomprometidos. Cuando están presentes, señales y síntomas son generalmente inespecíficos, volviendo el diagnóstico de compromiso cardíaco muy difícil antes de la autopsia. Arritmias ventriculares también son poco usuales en ese escenario. Describimos un caso de linfoma no Hodgkin miocárdico secundario, que se presentó con taquicardia ventricular monomórfica sustentada y engrosamiento del septo interventricular basal. Completa remisión de las lesiones miocárdicas fue observada después del término de la quimioterapia de segunda línea, sin recurrencias posteriores de arritmias en ocho meses.Systemic non-Hodgkin's lymphoma can affect the myocardium, particularly in immunocompromised patients. When present, symptoms and signs are usually nonspecific, making the diagnosis of cardiac involvement very difficult before an autopsy. Ventricular arrhythmias are also unusual in this setting. We describe a case of secondary myocardial non-Hodgkin's lymphoma presenting with sustained monomorphic ventricular tachycardia and thickening of the basal interventricular septum. Complete remission of myocardial lesions was observed after completion of second-line chemotherapy treatment, without further recurrences of arrhythmias in eight months.

Diego Chemello

2011-12-01

175

Linfoma gástrico tipo malt presentación de un caso  

Scientific Electronic Library Online (English)

Full Text Available SciELO Venezuela | Language: Spanish Abstract in spanish Paciente femenina, raza blanca, de 50 años de edad, que acudió a consulta de gastroenterología de la clínica Popular „Simón Bolívar‰ remitida de su área de salud, por presentar dolor abdominal de tipo epigastralgias, de moderada intensidad, de 2 meses de evolución, con sensación de ardor, además de [...] aparecer más recientemente náuseas y vómitos post-prandiales. La endoscopia superior evidenció lesiones nodulares del fondo y ulcerada del cardias, el estudio histopatológico con inmunohistoquímica reveló linfoma no Hodgkin de células B extranodal, del tejido linfoide asociado a mucosa (MALTOMA). Cumplió tratamiento erradicador para el Helicobacter pylori. Las endoscopias evolutivas mostraron evidente mejoría. Catorce meses después, la evaluación histopatológica reportó gastritis crónica atrófica sin atipias, ausencia de infección por Helicobacter pylori. Actualmente está asintomática y tiene seguimiento semestral. Abstract in english Female patient, Caucasian, 50 years old, who turned up for Gastroenterology consult of the „Simon Bolivar‰Popular Clinic, remitted from their health area , because of epigastric abdominal pain of moderate intensity with two months of evolution, with burning sensation, besides nauseas and vomiting. T [...] he upper digestive endoscopy showed a big ulceration in the cardial portion and granulate mucosa in the bottom of stomach. The histological study with inmunohistochemistry revealed a B extranodal cell non Hodgkin lymphoma of mucosa-associated lymphoid tissue (MALT). She completed treatment for eradication of Helicobacter pylori . Fourteen months later, the histopathologic evaluation reported a chronic atrophic gastritis without atypical cells and an absence of infection for Helicobacter pylori. At the moment she is asymptomatic and has a biannual follow-up.

Alfonso, Norlan de la Cruz; Zuleyma Carolina, De Jesús; Caridad, Kindelán Medina.

176

Anemia hemolítica autoinmune como manifestación inicial de linfoma hodgkin  

Scientific Electronic Library Online (English)

Full Text Available SciELO Venezuela | Language: Spanish Abstract in spanish Se presenta el caso de una paciente de 66 años de edad, a la que se le diagnostica anemia hemolítica, la cual fue refractaria al tratamiento y requirió esplenectomía. Además presenta adenomegalias inguinales, cuya biopsia determina infiltración parcial por células linfoides B CD20+, con atipia, y CD [...] 30+, con factor de proliferación alto; en médula ósea se constata incremento de linfocitos T. Cuatro meses después, consulta por la aparición de adenopatías inguinales y axilares, de las cuales la biopsia reveló enfermedad de Hodgkin variante esclerosis nodular, y en médula ósea se evidenció infiltración por la enfermedad linfoproliferativa. Si bien es infrecuente la asociación entre anemia hemolítica y linfoma Hodgkin, debe tenerse en cuenta para llegar a la búsqueda oportuna de su causa y al diagnóstico de un probable proceso linfoproliferativo subyacente. Abstract in english In this work we report and study a case of 66 year old woman, whit diagnosis of hemolytic anemia, which was refractory to treatment and she required splenectomy. The patient presented inguinal lymphadenopathy which biopsy has determined a partial infiltration of B-cells CD20 + and CD30 + with atypia [...] and high growth factor. The bone marrow biopsy informed an increased number of T lymphocytes. Four month later, the patient complained due to the appearance of inguinal and axillaries lymph nodes, which biopsy revealed a nodular sclerosis Hodgkin lymphoma. The bone marrow biopsy showed infiltration by lymphoproliferative disease. Although the association between hemolytic anemia and Hodgkin lymphoma is less frequent, this fact should be taken into account in searching its cause and reaching the diagnosis of a probable underlying lymphoproliferative process.

María Virginia, Bürgesser; Diego, Camps; Ana, Diller; Gastón, Caeiro.

177

Granuloma anular asociado a linfoma no Hodgkim difuso de células B grandes  

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Full Text Available Se presenta el caso de un paciente de 55 años con antecedentes de ser hipertenso controlado, atendido en servicio de hematología por adenopatías de características linfomatosas distribuidas en cadenas ganglionares, axilares, inguinales y epitrocleares distribuidas de forma bilateral. Los exámenes permitieron arribar al diagnóstico de un linfoma no Hogdkin difuso de células B grandes y de un granuloma anular.

Rafael Alejandro Gómez Baute

2011-08-01

178

Linfoma primario de hueso con afectación multicéntrica / Primary bone lymphoma with multicentric involvement  

Scientific Electronic Library Online (English)

Full Text Available SciELO Argentina | Language: Spanish Abstract in spanish El linfoma primario de hueso es una enfermedad infrecuente, que tiene una presentación y evolución diferente a los linfomas de otras localizaciones. Se presenta un caso de linfoma primario de hueso de localización craneana y esternal de rápido crecimiento. En su evolución, realizada la exéresis de l [...] a lesión primaria de calota, presentó aparición de nuevas lesiones de rápido crecimiento a nivel craneano y fémur y progresión de lesión preesternal que, con anatomía patológica de linfoma no Hodgkin difuso de células grandes B, inició R-CHOPP (ciclofosfamida, doxorrubicina, vincristina, prednisona y rituximab) con rápida disminución de todas las lesiones sin evidencia de progresión al cabo de los seis ciclos. Abstract in english Primary bone lymphoma is a rare disease, which usually has a different presentation and evolution than lymphomas of other locations. We are presenting a case of primary bone lymphoma of rapid growth, in cranial and sternal locations. In its evolution, once the excision of the primary lesion of the s [...] kull was performed, the patient presented new lesions of rapid growth at the skull and femur level, and progression of pre-sternal lesion. With large B-cell diffuse non-Hodgkin lymphoma pathology, the patient initiated R-CHOPP (cyclophosphamide, doxorubicin, vincristine, prednisone and rituximab) with rapid reduction of all lesions without evidence of progression after the six cycles.

Marcelo, Graziadio; Natalia, Medina; Marcelo, Amato; María del Carmen, Ardaiz; Santiago, Ilutovich; Marcelo, Torino.

2012-10-01

179

Linfoma primario de hueso con afectación multicéntrica Primary bone lymphoma with multicentric involvement  

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Full Text Available El linfoma primario de hueso es una enfermedad infrecuente, que tiene una presentación y evolución diferente a los linfomas de otras localizaciones. Se presenta un caso de linfoma primario de hueso de localización craneana y esternal de rápido crecimiento. En su evolución, realizada la exéresis de la lesión primaria de calota, presentó aparición de nuevas lesiones de rápido crecimiento a nivel craneano y fémur y progresión de lesión preesternal que, con anatomía patológica de linfoma no Hodgkin difuso de células grandes B, inició R-CHOPP (ciclofosfamida, doxorrubicina, vincristina, prednisona y rituximab con rápida disminución de todas las lesiones sin evidencia de progresión al cabo de los seis ciclos.Primary bone lymphoma is a rare disease, which usually has a different presentation and evolution than lymphomas of other locations. We are presenting a case of primary bone lymphoma of rapid growth, in cranial and sternal locations. In its evolution, once the excision of the primary lesion of the skull was performed, the patient presented new lesions of rapid growth at the skull and femur level, and progression of pre-sternal lesion. With large B-cell diffuse non-Hodgkin lymphoma pathology, the patient initiated R-CHOPP (cyclophosphamide, doxorubicin, vincristine, prednisone and rituximab with rapid reduction of all lesions without evidence of progression after the six cycles.

Marcelo Graziadio

2012-10-01

180

Linfoma primario de hueso con afectación multicéntrica / Primary bone lymphoma with multicentric involvement  

Scientific Electronic Library Online (English)

Full Text Available SciELO Argentina | Language: Spanish Abstract in spanish El linfoma primario de hueso es una enfermedad infrecuente, que tiene una presentación y evolución diferente a los linfomas de otras localizaciones. Se presenta un caso de linfoma primario de hueso de localización craneana y esternal de rápido crecimiento. En su evolución, realizada la exéresis de l [...] a lesión primaria de calota, presentó aparición de nuevas lesiones de rápido crecimiento a nivel craneano y fémur y progresión de lesión preesternal que, con anatomía patológica de linfoma no Hodgkin difuso de células grandes B, inició R-CHOPP (ciclofosfamida, doxorrubicina, vincristina, prednisona y rituximab) con rápida disminución de todas las lesiones sin evidencia de progresión al cabo de los seis ciclos. Abstract in english Primary bone lymphoma is a rare disease, which usually has a different presentation and evolution than lymphomas of other locations. We are presenting a case of primary bone lymphoma of rapid growth, in cranial and sternal locations. In its evolution, once the excision of the primary lesion of the s [...] kull was performed, the patient presented new lesions of rapid growth at the skull and femur level, and progression of pre-sternal lesion. With large B-cell diffuse non-Hodgkin lymphoma pathology, the patient initiated R-CHOPP (cyclophosphamide, doxorubicin, vincristine, prednisone and rituximab) with rapid reduction of all lesions without evidence of progression after the six cycles.

Marcelo, Graziadio; Natalia, Medina; Marcelo, Amato; María del Carmen, Ardaiz; Santiago, Ilutovich; Marcelo, Torino.

 
 
 
 
181

Design, construction, and validation of a rotary multifunctional intravascular diagnostic catheter combining multispectral fluorescence lifetime imaging and intravascular ultrasound  

Science.gov (United States)

We report the development and validation of an intravascular rotary catheter for bimodal interrogation of arterial pathologies. This is based on a point-spectroscopy scanning time-resolved fluorescence spectroscopy technique enabling reconstruction of fluorescence lifetime images (FLIm) and providing information on arterial intima composition and intravascular ultrasound (IVUS) providing information on arterial wall morphology. The catheter design allows for independent rotation of the ultrasonic and optical channels within an 8 Fr outer diameter catheter sheath and integrates a low volume flushing channel for blood removal in the optical pathways. In the current configuration, the two channels consist of (a) a standard 3 Fr IVUS catheter with single element transducer (40 MHz) and (b) a side-viewing fiber optic (400 ?m core). Experiments conducted in tissue phantoms showed the ability of the catheter to operate in an intraluminal setting and to generate coregistered FLIm and IVUS in one pull-back scan. Current results demonstrate the feasibility of the catheter for simultaneous bimodal interrogation of arterial lumen and for generation of robust fluorescence lifetime data under IVUS guidance. These results facilitate further development of a FLIm-IVUS technique for intravascular diagnosis of atherosclerotic cardiovascular diseases including vulnerable plaques.

Bec, Julien; Xie, Hongtao; Yankelevich, Diego R.; Zhou, Feifei; Sun, Yang; Ghata, Narugopal; Aldredge, Ralph; Marcu, Laura

2012-10-01

182

Las Historias de un Tratado Comercial  

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Full Text Available RESUMEN: ¿Cuáles son las razones que han favorecido un tratado de libre comercio en América del Norte? El artículo sugiere algunos de los intereses políticos y económicos inmersos en la negociacián. Como Canadá ya tiene su propio acuerdo con los Estados Unidos, su objetivo fundamental será evitar que México logre beneficios que pudieran perjudicarle. Para México, por su parte, el tratado puede ser la alternativa para recuperar el crecimiento económico, mientras que para Estados Unidos es una opción para mantener su competitividad frente a Europa y el Sudeste Asiático, y para reorientar sus relaciones con América Latina.ABSTRACT: Which are the reasons that are leading to a free-trade treaty in North America? The article suggests some economical and political interests involved in the negociation. As Canada has it's own agreement with the US, it would try to be ahead of Mexican benefits in the dkaL From Mexico's viewpoint, the treaty may be the alternative to restore economical growth, and for the US, it could be an option to mantain it's competitiveness against Europe and Southern Asia, and to reorientate it's relations with Latin America.

Sofía JASO GARCÍA

2009-11-01

183

Linfoma B difuso de células grandes en ovario: presentación de un caso  

Scientific Electronic Library Online (English)

Full Text Available SciELO Chile | Language: Spanish Abstract in spanish El linfoma B difuso de células grandes es un linfoma no Hodgkin de fenotipo B y gran agresividad, con una diseminación a ovario del 7%. Su presentación de forma primaria en ovario es muy poco común, representando el 0,5% de todos los linfomas no Hodgkin y el 1,5% de todos los tumores de ovario. En e [...] ste caso se presenta una paciente con clínica de dolor y distensión abdominal con una masa pélvica palpable, estableciéndose posteriormente el diagnóstico de linfoma B difuso de células grandes bilateral de ovario. En determinadas situaciones resulta complicado diferenciar el origen primario o secundario de la neoplasia. Los linfomas primarios localizados en ovario tienen un mejor pronóstico que los secundarios diseminados a ovario cuyo pronóstico es más sombrío. Sin embargo la mayoría de los casos publicados están basados en tratamiento quimioterápico previo a la era de rituximab. Abstract in english The diffuse large B-cell lymphoma is a highly aggressive phenotype B non-Hodgkin lymphoma which is characterized by 7% dissemination in the ovary. Its presentation in primary form in the ovary is very uncommon and accounts for 0.5% of all lymphomas. In this case, the patient presents symptoms of pai [...] n and abdominal strain with a palpable pelvic mass and a post-diagnosis of bilateral diffuse large B-cell lymphoma in the ovary. In certain situations, it is complicated to differentiate between the primary and secondary origin of the neoplasia. The primary lymphomas located in the ovary have a better prognosis than secondary lymphomas whose prognosis is more uncertain. However, the majority of published cases are subjected to chemothe-rapeutic treatment prior to rituximab.

Mariam, Abulhaj Martínez; Nicolás, Alayón Hernández; Rafael, Sotelo Avilés; Encarnación, Arévalo Reyes; Mercedes, Caba Molina; Mercedes, Gómez Morales.

184

Simultaneous occurrence of follicular lymphoma and mixed-cellularity Hodgkin's lymphoma: lymph node and extranodal involvement Ocorrência simultânea de linfoma folicular e linfoma de Hodgkin celularidade mista: envolvimento nodal e extranodal  

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Full Text Available An unusual and well-characterised case of composite lymphoma in the spleen and lymph node is presented. The simultaneous occurrence of mixed-cellularity Hodgkin's lymphoma (HL and follicular non-Hodgkin's lymphoma (NHL was demonstrated in a 66-year-old man admitted in our Service with anaemia, hepatosplenomegaly and multiple abdominal lymph nodes. The morphological study of the spleen and lymph node of the splenic hilum showed an infiltrate composed of two distinct neoplasias. The liver was involved by NHL infiltrate and the peripancreatic lymph node exhibited HL. The Reed-Sternberg (RS cells expressed CD 15 and CD 30, whereas the NHL cells presented standard immunohistochemical features of follicular lymphoma. To our knowledge, this is the fifth case report of concurrent spleen involvement by composite lymphoma. The incidence, clinicopathological and immunohistochemical features of this rare association are discussed.Os autores apresentam um caso raro e bem caracterizado de linfoma composto no baço e linfonodos. A ocorrência simultânea de um linfoma de Hodgkin e um linfoma não-Hodgkin foi demonstrada em um homem de 66 anos admitido com anemia, hepatosplenomegalia e múltiplos linfonodos abdominais. O estudo morfológico do baço e linfonodo do hilo esplênico mostrou infiltração por duas neoplasias distintas. O fígado estava envolvido por linfoma não-Hodgkin e o linfonodo peripancreático mostrava um linfoma de Hodgkin. As células de Reed-Sternberg (RS expressaram CD 15 e CD 30, enquanto as células do linfoma não-Hodgkin apresentaram os aspectos imunoistoquímicos clássicos do linfoma folicular. Na literatura médica, este é o quinto caso descrito de envolvimento do baço por linfoma composto. A incidência, aspectos clínicos e imunoistoquímicos desta rara associação são discutidos.

Maria do Patrocínio F. Grangeiro

2004-02-01

185

Simultaneous occurrence of follicular lymphoma and mixed-cellularity Hodgkin's lymphoma: lymph node and extranodal involvement / Ocorrência simultânea de linfoma folicular e linfoma de Hodgkin celularidade mista: envolvimento nodal e extranodal  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese Os autores apresentam um caso raro e bem caracterizado de linfoma composto no baço e linfonodos. A ocorrência simultânea de um linfoma de Hodgkin e um linfoma não-Hodgkin foi demonstrada em um homem de 66 anos admitido com anemia, hepatosplenomegalia e múltiplos linfonodos abdominais. O estudo morfo [...] lógico do baço e linfonodo do hilo esplênico mostrou infiltração por duas neoplasias distintas. O fígado estava envolvido por linfoma não-Hodgkin e o linfonodo peripancreático mostrava um linfoma de Hodgkin. As células de Reed-Sternberg (RS) expressaram CD 15 e CD 30, enquanto as células do linfoma não-Hodgkin apresentaram os aspectos imunoistoquímicos clássicos do linfoma folicular. Na literatura médica, este é o quinto caso descrito de envolvimento do baço por linfoma composto. A incidência, aspectos clínicos e imunoistoquímicos desta rara associação são discutidos. Abstract in english An unusual and well-characterised case of composite lymphoma in the spleen and lymph node is presented. The simultaneous occurrence of mixed-cellularity Hodgkin's lymphoma (HL) and follicular non-Hodgkin's lymphoma (NHL) was demonstrated in a 66-year-old man admitted in our Service with anaemia, hep [...] atosplenomegaly and multiple abdominal lymph nodes. The morphological study of the spleen and lymph node of the splenic hilum showed an infiltrate composed of two distinct neoplasias. The liver was involved by NHL infiltrate and the peripancreatic lymph node exhibited HL. The Reed-Sternberg (RS) cells expressed CD 15 and CD 30, whereas the NHL cells presented standard immunohistochemical features of follicular lymphoma. To our knowledge, this is the fifth case report of concurrent spleen involvement by composite lymphoma. The incidence, clinicopathological and immunohistochemical features of this rare association are discussed.

Maria do Patrocínio F., Grangeiro; Sílvia Maria M., Magalhães; Francisco Valdeci A., Ferreira; Francisco Dário, Rocha Filho.

186

Simultaneous occurrence of follicular lymphoma and mixed-cellularity Hodgkin's lymphoma: lymph node and extranodal involvement / Ocorrência simultânea de linfoma folicular e linfoma de Hodgkin celularidade mista: envolvimento nodal e extranodal  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese Os autores apresentam um caso raro e bem caracterizado de linfoma composto no baço e linfonodos. A ocorrência simultânea de um linfoma de Hodgkin e um linfoma não-Hodgkin foi demonstrada em um homem de 66 anos admitido com anemia, hepatosplenomegalia e múltiplos linfonodos abdominais. O estudo morfo [...] lógico do baço e linfonodo do hilo esplênico mostrou infiltração por duas neoplasias distintas. O fígado estava envolvido por linfoma não-Hodgkin e o linfonodo peripancreático mostrava um linfoma de Hodgkin. As células de Reed-Sternberg (RS) expressaram CD 15 e CD 30, enquanto as células do linfoma não-Hodgkin apresentaram os aspectos imunoistoquímicos clássicos do linfoma folicular. Na literatura médica, este é o quinto caso descrito de envolvimento do baço por linfoma composto. A incidência, aspectos clínicos e imunoistoquímicos desta rara associação são discutidos. Abstract in english An unusual and well-characterised case of composite lymphoma in the spleen and lymph node is presented. The simultaneous occurrence of mixed-cellularity Hodgkin's lymphoma (HL) and follicular non-Hodgkin's lymphoma (NHL) was demonstrated in a 66-year-old man admitted in our Service with anaemia, hep [...] atosplenomegaly and multiple abdominal lymph nodes. The morphological study of the spleen and lymph node of the splenic hilum showed an infiltrate composed of two distinct neoplasias. The liver was involved by NHL infiltrate and the peripancreatic lymph node exhibited HL. The Reed-Sternberg (RS) cells expressed CD 15 and CD 30, whereas the NHL cells presented standard immunohistochemical features of follicular lymphoma. To our knowledge, this is the fifth case report of concurrent spleen involvement by composite lymphoma. The incidence, clinicopathological and immunohistochemical features of this rare association are discussed.

Maria do Patrocínio F., Grangeiro; Sílvia Maria M., Magalhães; Francisco Valdeci A., Ferreira; Francisco Dário, Rocha Filho.

2004-02-01

187

Primary diffuse large B-cell lymphoma of the oral cavity / Linfoma difuso de grandes células B primário de boca  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese Linfomas correspondem a 3,5% de todos os casos de lesões malignas de boca. O linfoma difuso de grandes células B é um subtipo de linfoma não-Hodgkin caracterizado pela proliferação difusa de células linfóides B. Este artigo relata um caso de linfoma difuso de grandes células B localizado na cavidade [...] bucal de uma mulher brasileira, incluindo os achados clínicos, microscópicos, imuno-histoquímicos e moleculares. Abstract in english Lymphomas arising within the oral cavity account for only 3.5% of all oral malignancies. Diffuse large B-cell lymphoma is a non-Hodgkin lymphoma subtype characterized by diffuse proliferation of large neoplastic B lymphoid cells. This paper reports a case of diffuse large B-cell lymphoma affecting t [...] he oral cavity of a Brazilian woman, along with its clinical, microscopical, immunohistochemical, and molecular features.

Bruno Correia, Jham; Eliza Carla Barroso, Duarte; Anacélia Mendes, Fernandes; Aline Cristina Batista Rodrigues, Johann; Maria Cássia Ferreira, Aguiar; Ricardo Santiago, Gomez; Ricardo Alves, Mesquita.

188

Primary central nervous system lymphomas in immunocompetent patients / Linfomas primarios del sistema nervioso central en pacientes immunocompetentes  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: English Abstract in spanish Objetivos. En este trabajo presentamos nuestra casuística de linfomas cerebrales primarios en pacientes immunocompetentes comparandolo con los datos previos de la literatura, con especial enfoque en los recientes avaces, investigaciones, y controversias acerca del diagnóstico y manejo terapéutico de [...] estas patologías. Material y método. Nueve pacientes operados el año pasado en nuestra clínica con diagnóstico de PCNLS son analizados en relación al sexo, edad, tiempo de sintomatología, procedimientos y tratamiento. Posteriormente, los resultados son comparados con los de la literatura. Resultados. La edad varió entre 44-68 años (media de 60,6 años); 62,5% de los pacientes fueron del sexo femenino; el tiempo medio de duración de los síntomas antes del diagnóstico de la enfermedad varió de 1-6 meses, con un rango medio de 3,2 meses. Los síntomas clínicos más frecuentes fueron : hemiparesia (75%), cefalea (37,5), crisis convulsivas (25%) y ataxia (25%). Las localizaciones predominaron en las superficies de los lóbulos parietal, temporal y frontal con un 25% para cada una de las localizaciones citadas. Cinco pacientes (50%) fueron tratados con biopsia estereotáxica, tres con cirugía (37.5%) y uno (12.5%) con ambas. Cinco pacientes (62,5%) fueron sometidos a radioterapia postoperatoria como tratamiento adyuvante. En relación con el tipo histológico predominó el linfoma de células difusas tipo B. Conclusiones. Este estudio demostró que la resección quirúrgica, combinada con biopsia por esterotaxia y la radioterapia dan buenos resultados. Los autores recomiendan la quimioterapia solamente como segunda línea de tratamiento, en pacientes seleccionados. Abstract in english Objectives. Primary central nervous system lymphoma (PCNSL) is a rare pathology and is most often seen in immunodeficient patients. This article presents our casuistic of PCNSL in immunocompetent patients and make a literature review on this issue with focus on recent advances, investigations, and c [...] ontroversies in diagnosis and management of this pathology. Matherial and methods. Nine patients operated in the last years in our clinics are analysed in relation to sex, age, time of symptoms, procedures and adjuvant treatment. Posteriorly the results are compared with those in the preview literature. Results. The age ranged from 44-68 years (middle of 66 years); 62,5% of the patients were female. The mean time of symptoms, when the diagnostic was made, was 3.2 months (range 1-6 months). The most common symptoms were hemiparesis (present in 75% of the patients) headache (37.5%) seizures (25%) and ataxia (25%). The most common localization was the parietal, frontal and temporal lobe surface with 25% of the patients for each localization. Five patients (50%) were treated with stereotactic biopsy, three with surgery (37.5%) and one (12.5%) with both of them. Five patients (62,5%) were submitted to pos-operative radiotherapy as adjuvant treatment. In relation to the hystology, the most common cell type was Difuse B Cells. Conclusions. This study demonstrated that complete surgical ressection followed by radiotherapy have shown good results. In opposition to the literature, the authors regard chemotherapy as a secondary line treatment and recommend its use only in some selected cases.

T., Alécio-Mattei; J., Alécio-Mattei; P.H., Aguiar; R., Ramina.

2006-02-01

189

Primary central nervous system lymphomas in immunocompetent patients / Linfomas primarios del sistema nervioso central en pacientes immunocompetentes  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: English Abstract in spanish Objetivos. En este trabajo presentamos nuestra casuística de linfomas cerebrales primarios en pacientes immunocompetentes comparandolo con los datos previos de la literatura, con especial enfoque en los recientes avaces, investigaciones, y controversias acerca del diagnóstico y manejo terapéutico de [...] estas patologías. Material y método. Nueve pacientes operados el año pasado en nuestra clínica con diagnóstico de PCNLS son analizados en relación al sexo, edad, tiempo de sintomatología, procedimientos y tratamiento. Posteriormente, los resultados son comparados con los de la literatura. Resultados. La edad varió entre 44-68 años (media de 60,6 años); 62,5% de los pacientes fueron del sexo femenino; el tiempo medio de duración de los síntomas antes del diagnóstico de la enfermedad varió de 1-6 meses, con un rango medio de 3,2 meses. Los síntomas clínicos más frecuentes fueron : hemiparesia (75%), cefalea (37,5), crisis convulsivas (25%) y ataxia (25%). Las localizaciones predominaron en las superficies de los lóbulos parietal, temporal y frontal con un 25% para cada una de las localizaciones citadas. Cinco pacientes (50%) fueron tratados con biopsia estereotáxica, tres con cirugía (37.5%) y uno (12.5%) con ambas. Cinco pacientes (62,5%) fueron sometidos a radioterapia postoperatoria como tratamiento adyuvante. En relación con el tipo histológico predominó el linfoma de células difusas tipo B. Conclusiones. Este estudio demostró que la resección quirúrgica, combinada con biopsia por esterotaxia y la radioterapia dan buenos resultados. Los autores recomiendan la quimioterapia solamente como segunda línea de tratamiento, en pacientes seleccionados. Abstract in english Objectives. Primary central nervous system lymphoma (PCNSL) is a rare pathology and is most often seen in immunodeficient patients. This article presents our casuistic of PCNSL in immunocompetent patients and make a literature review on this issue with focus on recent advances, investigations, and c [...] ontroversies in diagnosis and management of this pathology. Matherial and methods. Nine patients operated in the last years in our clinics are analysed in relation to sex, age, time of symptoms, procedures and adjuvant treatment. Posteriorly the results are compared with those in the preview literature. Results. The age ranged from 44-68 years (middle of 66 years); 62,5% of the patients were female. The mean time of symptoms, when the diagnostic was made, was 3.2 months (range 1-6 months). The most common symptoms were hemiparesis (present in 75% of the patients) headache (37.5%) seizures (25%) and ataxia (25%). The most common localization was the parietal, frontal and temporal lobe surface with 25% of the patients for each localization. Five patients (50%) were treated with stereotactic biopsy, three with surgery (37.5%) and one (12.5%) with both of them. Five patients (62,5%) were submitted to pos-operative radiotherapy as adjuvant treatment. In relation to the hystology, the most common cell type was Difuse B Cells. Conclusions. This study demonstrated that complete surgical ressection followed by radiotherapy have shown good results. In opposition to the literature, the authors regard chemotherapy as a secondary line treatment and recommend its use only in some selected cases.

T., Alécio-Mattei; J., Alécio-Mattei; P.H., Aguiar; R., Ramina.

190

Percutaneous intravascular metallic stent placement in chronic iliac artery stenoses  

International Nuclear Information System (INIS)

To determine the long-term patency of percutaneous intravascular metallic stent placement in patients with chronic iliac artery stenosis. Intravascular metallic stents were placed percutaneously in 41 limbs of 38 patients with chronic iliac artery stenosis who presented with intermittent claudication in 40 limbs and gangrene in the other. Preoperative angiography showed that complete occlusion occurred in one limb, and luminal stenosis of over 50% in 34 and of less than 50% in six. The mean length of stenoses was 3.1 (range, 1-8) cm, and in all cases the systolic pressure gradient was over 10 (range, 12-100, mean, 43) mmHg. Stent placement was indicated by failed balloon angioplasty in 35 limbs, primary stenting in five, and restenosis after balloon angioplasty in one. Technical and clinical success were evaluated in terms of immediate results and stent patency over a period of 1-49 (mean, 19) months (Kaplan-Meier method). Stent placement was successful in all cases in which residual stenosis was less than 10% and systolic pressure gradient less than 2 mmHg. One to three days after the procedure, clinical symptoms had improved in 40 limbs and ABI (n=23) had increased from 0.64±0.20 to 0.92±0.17. Follow-up studies demonstrated patency rates of 94.1% at 6 months, 90.7% at 1 year, 86.6% at 2 years, and 86.6% at 4 years. Our results showed that in patients with chronic iliac artery stenosis, percutaneous intravascular metallic stent placement led to patency rates which nt placement led to patency rates which were similar over a period of between six months and four years

191

Prevention of adverse reactions to intravascular contrast media  

International Nuclear Information System (INIS)

The exact mechanisms of adverse reactions to contrast media are still imperfectly known. However, these reactions may be classified as idiosyncratic. Non-idiosyncratic reactions can be prevented by using new, non-ionic contrast agents. Idiosyncratic reactions can be prevented by specific premedication. Patients with a history of idiosyncratic reaction may benefit from corticosteroids and antihistamines administered prophylactically. Patients who seem to be more likely than others to react to contrast media must be premedicated, the risk of reaction being identified and evaluated by questioning. It has recently been suggested that all patients about to receive an intravascular injection of contrast medium should also be premedicated

192

Intravascular Papillary Endothelial Hyperplasia(Masson's Tumor) of the Chest Wall: A Case Report  

International Nuclear Information System (INIS)

Intravascular papillary endothelial hyperplasia is a rare tumor-like lesion caused by hyperplastic proliferation of endothlial cells that is usually an incidental findings within thrombosed dilated blood vessels or vascular tumor. We report the sonographic appearance and pathological correlation of intravascular papillary endothelial hyperplasia that presented as an intramuscular solitary mass in chest wall

193

Intravascular papillary endothelial hyperplasia (Masson's tumor) presenting as a triceps mass  

International Nuclear Information System (INIS)

Intravascular papillary endothelial hyperplasia (IPEH) is a nonneoplastic reactive endothelial proliferation most commonly located in the skin or subcutaneous tissues although it has been reported in multiple locations throughout the body. We present a case of intravascular papillary endothelial hyperplasia presenting as a soft tissue mass in the triceps muscle. IPEH is not well-described in the radiologic literature. (orig.)

194

Remoção percutânea de fragmento de cateter intravascular: uma adaptação da caixa de ferramentas / Percutaneous removal of intravascular catheter fragment: an adaptation of the toolbox  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese A fragmentação de um cateter intravascular foi primeiramente publicada em 1954 e, desde então, observamos notável evolução das técnicas de retirada de corpo estranho intravascular. A descrição pioneira de remoção não cirúrgica de corpo estranho data de 1964, com o relato da retirada de fragmento de [...] fio-guia com auxílio de um fórceps de biópsia para broncoscópio. Apesar da disponibilidade de variados dispositivos dedicados, por vezes, para se ter sucesso, é necessária a adaptação de materiais. Relatamos aqui o caso de uma portadora de cateter Port-a-Cath em veia subclávia esquerda, implantado 5 anos antes, que rompeu a porção intravascular durante sua retirada, tendo sido removido com sucesso por via percutânea. Abstract in english The first report of an intravascular catheter fragmentation was published in 1954 and ever since we have observed a remarkable evolution in the techniques of intravascular foreign body removal. The pioneer description of non-surgical foreign body removal dates back to 1964, with the report of a guid [...] ewire fragment withdrawal using a bronchoscopy biopsy forceps. Despite the availability of several dedicated devices, materials may have to be adapted at times to achieve technical success. We report the case of a patient with a Port-a-Cath catheter in the left subclavian vein, which had been placed 5 years before and whose intravascular portion was broken during withdrawal. It was successfully removed using the percutaneous approach.

Igor Ribeiro de Castro, Bienert; Rodolfo L. L. A. F., Chiozzi; Carlos E. C., Mota; João Saes, Braga; Rubio, Bombonato; Luís Junya, Kajita.

195

Retinal and choroidal intravascular spectral-domain optical coherence tomography  

DEFF Research Database (Denmark)

Purpose:? To examine retinal and choroidal blood vessels using spectral-domain optical coherence tomography (SD-OCT). Methods:? Retrospective case series. Results:? Scans through retinal blood vessels in healthy subjects demonstrated vessel wall reflexes and a tri-layer profile of the blood column on longitudinal scans and a figure-of-eight configuration on cross-sectional scans. Intravascular reflectivity decreased with increasingly oblique angles of observation and was absent when blood flow was parallel to the line of sight. The high blood flow in the choroidal vessels in healthy subjects and the low flow in the retinal vessels in patients with ocular ischaemic syndrome and central retinal artery occlusion were both associated with lower reflectivity of the blood and an unstructured intravascular SD-OCT profile. Discussion:? This qualitative in vivo study found a characteristically structured SD-OCT profile of the blood column in retinal vessels with normal blood flow. Both structure and total reflectivityfaded when blood flow was lower or higher than normal or at oblique angles to the line of sight. In conclusion, SD-OCT scans of the vessels in the posterior pole of the eye may assist the clinical assessment of gross abnormalities of ocular blood flow, e.g. in carotid artery stenosis.

Willerslev, Anne; Li, Xiao Q

2013-01-01

196

Experience With Intravascular Ultrasound Imaging Of Human Atherosclerotic Arteries  

Science.gov (United States)

Normal human arteries have a well-defined structure on intravascular images. The intima appears very thin and is most likely represented by a bright reflection arising from the internal elastic lamina. The smooth muscle tunica media is echo-lucent on the ultrasound image and appears as a dark band separating the intima from the adventitia. The adventitia is a brightly reflective layer of variable thickness. The thickness of the intima, and therefore of the atherosclerotic plaque can be accurately measured from the ultrasound images and correlates well with histology. Calcification within the wall of arteries is seen as bright echo reflection with shadowing of the peripheral wall. Fibrotic regions are highly reflective but do not shadow. Necrotic liquid regions within advanced atherosclerotic plaques are seen on ultrasound images as large lucent zones surrounded by echogenic tissue. Imaging can be performed before and after interventional procedures, such as laser angioplasty, balloon angioplasty and atherectomy. Intravascular ultrasound appears to provide an imaging modality for identifying the histologic characteristics of diseased arteries and for quantifying plaque thickness. It might be possible to perform such quantification to evaluate the results of interventional procedures.

Mallery, John A.; Gessert, James M.; Maciel, Mario; Tobis, John M.; Griffith, James M.; Berns, Michael W.; Henry, Walter L.

1989-08-01

197

Thyroid Storm Complicated by Bicytopenia and Disseminated Intravascular Coagulation  

Science.gov (United States)

Patient: Male, 23 Final Diagnosis: Thyroid storm Symptoms: Delirium • diarrhea • fever • hypertension • hyperventilation • tachycardia • weight loss Medication: — Clinical Procedure: — Specialty: Endocrinology and Metabolic Objective: Unusual clinical course Background: The clinical presentation of thyroid storm includes fever, tachycardia, hypertension, and neurological abnormalities. It is a serious condition with a high mortality rate. Furthermore, some other complications affect the clinical course of thyroid storm. Although it is reported that prognosis is poor when thyroid storm is complicated by disseminated intravascular coagulation syndrome (DIC) and leukopenia, reports of such cases are rare. Case Report: A 23-year-old man presented with delirium, high pyrexia, diarrhea, and weight loss of 18 kg over 2 months. According to the criteria of Burch and Wartofsky, he was diagnosed with thyroid storm on the basis of his symptom-complex and laboratory data that confirmed the presence of hyperthyroidism. Investigations also found leukopenia, thrombocytopenia, and disseminated intravascular coagulation, all of which are very rare complications of thyroid storm. We successfully treated him with combined therapy including anti-thyroid medication, despite leukopenia. Conclusions: Early diagnosis and treatment are essential in ensuring a good outcome for patients with this rare combination of medical problems. PMID:25072662

Tokushima, Yoshinori; Sakanishi, Yuta; Nagae, Kou; Tokushima, Midori; Tago, Masaki; Tomonaga, Motosuke; Yoshioka, Tsuneaki; Hyakutake, Masaki; Sugioka, Takashi; Yamashita, Shu-ichi

2014-01-01

198

Development of {sup 192}Ir radiation sources for intravascular irradiation  

Energy Technology Data Exchange (ETDEWEB)

Intravascular brachytherapy is a novel therapy for preventing the restenosis of coronary artery by use of low-dose irradiation. JAERI and Kyoto University have been developing {sup 192}Ir radiation sources by the cooperative research project entitled as 'The research on safety and effectiveness of the intravascular brachytherapy for preventing restenosis of the coronary artery disease' since 1998. The radiation source was introduced into the stenosis through a catheter (a guide-tube to insert directly into vascular) to irradiate the diseased part. Ten {sup 192}Ir seed sources ({phi}0.4 mm x 2.5 mm) were positioned between nylon spacers ({phi}0.3 mm x 1.0 mm) in a flexible covering tube and the tube was plugged with a core-wire; the tube was shrunk to fix the inside materials and the size is 0.46 mm in diameter and 3 m in length. The physically optimal design was determined to insert the radiation source easily into vascular and to get the dose uniformity in the diseased part. The production method of the radiation source, which is practical to use in the clinics was also established. (author)

Kogure, Hiroto; Sorita, Takami; Iwamoto, Seikichi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Nagata, Yasushi; Hiraoka, Masahiro [Kyoto Univ., Kyoto (Japan); Iwata, Kazuro [Nara Medical Univ., Nara (Japan); Kawauchi, Yukimasa; Suzuki, Kazutoshi [Chiyoda Technol Corp., Tokyo (Japan)

2003-03-01

199

Improving quantification of intravascular fluorescence imaging using structural information  

International Nuclear Information System (INIS)

Intravascular near-infrared fluorescence (iNIRF) imaging can enable the in vivo visualization of biomarkers of vascular pathology, including high-risk plaques. The technique resolves the bio-distribution of systemically administered fluorescent probes with molecular specificity in the vessel wall. However, the geometrical variations that may occur in the distance between fibre-tip and vessel wall can lead to signal intensity variations and challenge quantification. Herein we examined whether the use of anatomical information of the cross-section vessel morphology, obtained from co-registered intravascular ultrasound (IVUS), can lead to quantification improvements when fibre-tip and vessel wall distance variations are present. The algorithm developed employs a photon propagation model derived from phantom experiments that is used to calculate the relative attenuation of fluorescence signals as they are collected over 360° along the vessel wall, and utilizes it to restore accurate fluorescence readings. The findings herein point to quantification improvements when employing hybrid iNIRF, with possible implications to the clinical detection of high-risk plaques or blood vessel theranostics. (paper)

200

Improving quantification of intravascular fluorescence imaging using structural information  

Science.gov (United States)

Intravascular near-infrared fluorescence (iNIRF) imaging can enable the in vivo visualization of biomarkers of vascular pathology, including high-risk plaques. The technique resolves the bio-distribution of systemically administered fluorescent probes with molecular specificity in the vessel wall. However, the geometrical variations that may occur in the distance between fibre-tip and vessel wall can lead to signal intensity variations and challenge quantification. Herein we examined whether the use of anatomical information of the cross-section vessel morphology, obtained from co-registered intravascular ultrasound (IVUS), can lead to quantification improvements when fibre-tip and vessel wall distance variations are present. The algorithm developed employs a photon propagation model derived from phantom experiments that is used to calculate the relative attenuation of fluorescence signals as they are collected over 360° along the vessel wall, and utilizes it to restore accurate fluorescence readings. The findings herein point to quantification improvements when employing hybrid iNIRF, with possible implications to the clinical detection of high-risk plaques or blood vessel theranostics.

Mallas, Georgios; Brooks, Dana H.; Rosenthal, Amir; Nika Nudelman, R.; Mauskapf, Adam; Jaffer, Farouc A.; Ntziachristos, Vasilis

2012-10-01

 
 
 
 
201

Causas de mortalidad en pacientes con linfoma de Hodgkin / Causes of mortality in patients with Hodgkin lymphoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Se realizó un estudio retrospectivo-descriptivo en el Servicio de Hematología del Hospital Clinicoquirúrgico "Hermanos Ameijeiras" para conocer las causas de muerte en pacientes con diagnóstico de linfoma de Hodgkin tratados desde enero de 1983 hasta diciembre de 2008. De los 619 pacientes diagnosti [...] cados en ese período, la muestra quedó constituida por 443, de los cuales 287 (64,8 %) se encontraban vivos al final del estudio y 156 (35,2 %) habían fallecido. La recaída/progresión de la enfermedad fue la causa más importante de muerte, independientemente de la edad de presentación, la modalidad de tratamiento empleada y el tiempo de evolución (125 pacientes, 80 %). El 20 % restante de las muertes ocurrió por segundas neoplasias en 10 pacientes (6,4 %), complicaciones del tratamiento en 8 (5,1 %), complicaciones infecciosas fatales en 2 (1,2 %) y enfermedad cardiovascular en 3 (1,9 %). En 8 pacientes (5,1 %) no se precisó la causa de muerte. Las segundas neoplasias predominaron en pacientes de 40-59 años, que recibieron la modalidad de tratamiento combinada y con menos de 10 años de evolución. Abstract in english A retrospective descriptive study was conducted in the Hematology Service at Hermanos Ameijeriras Hospital to know the causes of death in patients with Hodgkin lymphoma, who were treated from January 1983 to December 2008. Out of 619 patients diagnosed in that period, the total sample was formed by [...] 443 patients. 287 (64.8 %) of them were alive at the end of the study, and 156 (35.2%) had died. This disease relapse/progression were the leading cause of death, regardless age of its presentation, treatment used, and the time of progression (125 patients, 80 %). The remaining 20 % of deaths occurred from secondary malignancies in 10 patients (6.4 %), complications of treatment in 8 (5.1 %), fatal infectious complications in 2 (1.2 %), and cardiovascular disease in 3 (1.9 %). In 8 patients (5.1 %) the cause of death was not stated. Secondary malignancies were predominant in patients aged 40-59, who received combined treatment with less than 10 years of evolution.

Tamara, Delgado Vargas; José, Carnot Uria; Raúl, de Castro Arenas; Jorge, Muñío Perurena; Calixto, Hernández Cruz; Aramís, Núñez Quintana; Guillermo, Pérez Román; Yusaima, Rodríguez Fraga.

2013-12-01

202

Causas de mortalidad en pacientes con linfoma de Hodgkin / Causes of mortality in patients with Hodgkin lymphoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Se realizó un estudio retrospectivo-descriptivo en el Servicio de Hematología del Hospital Clinicoquirúrgico "Hermanos Ameijeiras" para conocer las causas de muerte en pacientes con diagnóstico de linfoma de Hodgkin tratados desde enero de 1983 hasta diciembre de 2008. De los 619 pacientes diagnosti [...] cados en ese período, la muestra quedó constituida por 443, de los cuales 287 (64,8 %) se encontraban vivos al final del estudio y 156 (35,2 %) habían fallecido. La recaída/progresión de la enfermedad fue la causa más importante de muerte, independientemente de la edad de presentación, la modalidad de tratamiento empleada y el tiempo de evolución (125 pacientes, 80 %). El 20 % restante de las muertes ocurrió por segundas neoplasias en 10 pacientes (6,4 %), complicaciones del tratamiento en 8 (5,1 %), complicaciones infecciosas fatales en 2 (1,2 %) y enfermedad cardiovascular en 3 (1,9 %). En 8 pacientes (5,1 %) no se precisó la causa de muerte. Las segundas neoplasias predominaron en pacientes de 40-59 años, que recibieron la modalidad de tratamiento combinada y con menos de 10 años de evolución. Abstract in english A retrospective descriptive study was conducted in the Hematology Service at Hermanos Ameijeriras Hospital to know the causes of death in patients with Hodgkin lymphoma, who were treated from January 1983 to December 2008. Out of 619 patients diagnosed in that period, the total sample was formed by [...] 443 patients. 287 (64.8 %) of them were alive at the end of the study, and 156 (35.2%) had died. This disease relapse/progression were the leading cause of death, regardless age of its presentation, treatment used, and the time of progression (125 patients, 80 %). The remaining 20 % of deaths occurred from secondary malignancies in 10 patients (6.4 %), complications of treatment in 8 (5.1 %), fatal infectious complications in 2 (1.2 %), and cardiovascular disease in 3 (1.9 %). In 8 patients (5.1 %) the cause of death was not stated. Secondary malignancies were predominant in patients aged 40-59, who received combined treatment with less than 10 years of evolution.

Tamara, Delgado Vargas; José, Carnot Uria; Raúl, de Castro Arenas; Jorge, Muñío Perurena; Calixto, Hernández Cruz; Aramís, Núñez Quintana; Guillermo, Pérez Román; Yusaima, Rodríguez Fraga.

203

Linfoma não-Hodgkin endobrônquico / Endobronchial involvement in non-Hodgkin’s lymphoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Os linfomas não-Hodgkin fazem parte de um grupo de doenças malignas linfoproliferativas com diferentes padrões de comportamento, de tratamento e de prognóstico. Eles podem comprometer as estruturas intratorácicas, particularmente o mediastino e o parênquima pulmonar, em alguma fase do curso da doenç [...] a. Entretanto, o envolvimento endobrônquico é extremamente raro, mesmo na presença de doença avançada. Os autores relatam um caso de linfoma não-Hodgkin endobrônquico e fazem revisão da literatura. Abstract in english Non-Hodgkin’s lymphomas belong to a group of lymphoproliferative malignancies with different behavior, treatment and prognostic patterns. During the course of the disease, they may affect the thoracic structures - especially the mediastinum and the pulmonary parenchyma. However endobronchial involve [...] ment is extremely uncommon, even in presence of advanced disease. Here, we report a case of non-Hodgkin’s endobronchial lymphoma and make a review of the literature.

Mauro, Zamboni; Aureliano Mota Cavalcanti de, Sousa; Deborah Cordeiro, Lannes; Cristina Maria Cantarino, Gonçalves; Edson Toscano, Cunha; Samuel Zwinglio de Biasi, Cordeiro; Paulo de Biasi, Cordeiro.

204

Linfoma não-Hodgkin endobrônquico Endobronchial involvement in non-Hodgkin’s lymphoma  

Directory of Open Access Journals (Sweden)

Full Text Available Os linfomas não-Hodgkin fazem parte de um grupo de doenças malignas linfoproliferativas com diferentes padrões de comportamento, de tratamento e de prognóstico. Eles podem comprometer as estruturas intratorácicas, particularmente o mediastino e o parênquima pulmonar, em alguma fase do curso da doença. Entretanto, o envolvimento endobrônquico é extremamente raro, mesmo na presença de doença avançada. Os autores relatam um caso de linfoma não-Hodgkin endobrônquico e fazem revisão da literatura.Non-Hodgkin’s lymphomas belong to a group of lymphoproliferative malignancies with different behavior, treatment and prognostic patterns. During the course of the disease, they may affect the thoracic structures - especially the mediastinum and the pulmonary parenchyma. However endobronchial involvement is extremely uncommon, even in presence of advanced disease. Here, we report a case of non-Hodgkin’s endobronchial lymphoma and make a review of the literature.

Mauro Zamboni

2004-02-01

205

Primary pulmonary AIDS-related lymphoma Linfoma primario de pulmón en un paciente con sida  

Directory of Open Access Journals (Sweden)

Full Text Available Extranodal involvement is common in lymphomas associated with human immunodeficiency virus infection (HIV and acquired immunodeficiency syndrome (AIDS. However, primary pulmonary AIDS-related non-Hodgkin's lymphoma is very rare and only few reports were published in the medical literature. Clinical presentation is nonspecific, with "B" and respiratory symptoms. Also, patients were with advanced immunodeficiency at the time of diagnosis. Generally, chest radiography showed peripheral nodules or cavitary masses. Primary pulmonary lymphoma associated with AIDS is generally a high-grade B-cell non-Hodgkin lymphoma and Epstein-Barr virus is strongly associated with the pathogenesis of these tumors. We report a patient with AIDS and primary pulmonary lymphoma which clinical presentation was a total atelectasis of the left lung.El compromiso extranodal es frecuente en los linfomas asociados con la enfermedad debida al virus de la inmunodeficiencia humana y su consecuencia, el síndrome de inmunodeficiencia adquirida. Sin embargo, el linfoma pulmonar primario es muy raro y solo existen pocos casos publicados en la literatura. La presentación clínica de esta complicación es inespecífica, con síntomas "B" y manifestaciones respiratorias. Generalmente, la radiografía de tórax muestra nódulos periféricos o masas que pueden cavitarse y los pacientes presentan inmunodeficiencia severa al momento del diagnóstico. El linfoma pulmonar primario asociado con el sida es un tumor de alto grado, de células B y asociado en su patogenia con el virus de Epstein-Barr. Se relata un caso de linfoma primario de pulmón que se presentó bajo la forma radiológica de una atelectasia global del pulmón izquierdo.

Marcelo Corti

2005-08-01

206

Primary pulmonary AIDS-related lymphoma / Linfoma primario de pulmón en un paciente con sida  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in spanish El compromiso extranodal es frecuente en los linfomas asociados con la enfermedad debida al virus de la inmunodeficiencia humana y su consecuencia, el síndrome de inmunodeficiencia adquirida. Sin embargo, el linfoma pulmonar primario es muy raro y solo existen pocos casos publicados en la literatura [...] . La presentación clínica de esta complicación es inespecífica, con síntomas "B" y manifestaciones respiratorias. Generalmente, la radiografía de tórax muestra nódulos periféricos o masas que pueden cavitarse y los pacientes presentan inmunodeficiencia severa al momento del diagnóstico. El linfoma pulmonar primario asociado con el sida es un tumor de alto grado, de células B y asociado en su patogenia con el virus de Epstein-Barr. Se relata un caso de linfoma primario de pulmón que se presentó bajo la forma radiológica de una atelectasia global del pulmón izquierdo. Abstract in english Extranodal involvement is common in lymphomas associated with human immunodeficiency virus infection (HIV) and acquired immunodeficiency syndrome (AIDS). However, primary pulmonary AIDS-related non-Hodgkin's lymphoma is very rare and only few reports were published in the medical literature. Clinica [...] l presentation is nonspecific, with "B" and respiratory symptoms. Also, patients were with advanced immunodeficiency at the time of diagnosis. Generally, chest radiography showed peripheral nodules or cavitary masses. Primary pulmonary lymphoma associated with AIDS is generally a high-grade B-cell non-Hodgkin lymphoma and Epstein-Barr virus is strongly associated with the pathogenesis of these tumors. We report a patient with AIDS and primary pulmonary lymphoma which clinical presentation was a total atelectasis of the left lung.

Marcelo, Corti; María F., Villafañe; Norberto, Trione; Ricardo, Schtirbu; Marina, Narbaitz.

207

Nuevos marcadores pronósticos derivados de las signaturas del microambiente tumoral en linfoma difuso de células grandes  

Digital Repository Infrastructure Vision for European Research (DRIVER)

La presente tesis incluye dos trabajos: PRIMER TRABAJO High microvessel density determines a poor outcome in patients with diffuse large B-cell lymphoma treated with rituximab plus chemotherapy Cardesa-Salzmann et al. Haematologica. 2011; 96(7):996-1001. RESUMEN: Introducción: El linfoma difuso de células grandes (LDCG) es una enfermedad heterogénea a nivel clínico y a nivel molecular. Estudios de expresión génica han demostrado que el microambiente tumoral afec...

Cardesa Salzmann, Teresa

2014-01-01

208

Linfoma tipo MALT de la glándula parótida / Lymphoma type MALT of the parotid gland  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Los linfomas tipo MALT (tejido linfoideo asociado a mucosa), constituyen la variedad más recientemente descubierta de los linfomas no Hodgkin, tienen lugar fundamentalmente en la mucosa gástrica asociados a infección por Helycobacter pylori, y en la glándula tiroides en relación con la tiroiditis de [...] Hashimoto. Sin embargo, internacionalmente se han descrito casos en glándulas salivales asociados a linfoadenitis. La naturaleza de la lesión a menudo no puede ser determinada solo por el estudio citológico; se hace necesario el análisis histopatológico para el diagnóstico definitivo en la mayoría de los casos. El presente estudio muestra un paciente masculino con aumento de volumen bilateral de ambas glándulas parótidas y diagnóstico citohistopatológico de un proceso linfoepitelial benigno, el cual desarrolló un linfoma tipo MALT en relación con la glándula parótida derecha. Abstract in english The lymphomas type MALT or the mucosa-associated lymphoid tissue, are the most recent variety of non-Hodgkin lymphomas present mainly in the gastric mucosa associated with Helycobacter pylori infection and in the thyroid gland in relation to Hashimoto's thyroiditis. Frequently the origin of this les [...] ion can't be determined only by cytology study, thus it is necessary the histopathology analysis for a definitive diagnosis in most cases. Present paper includes the case of male patient with bilateral volume increase of both parotid glands and a diagnosis cytopathological of a benign lymphoepithelial process and the development of a type MALT lymphoma in relation to the right parotid gland.

Carlos, Frómeta Neira; Juan Manuel, González Gómez; Miguel, Arredondo López.

2010-09-01

209

Linfoma cutâneo de células B: relato de caso / Cutaneous B-cell lymphoma: a case report  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Os linfomas cutâneos são classificados em linfomas de células B ou de células T, sendo os primeiros menos freqüentes. O linfoma cutâneo de células B (LCCB) pode ser primário ou secundário, tendo o último história natural mais agressiva, com pior prognóstico. Os autores apresentam um caso de LCCB sec [...] undário com três anos de evolução, curso indolente, sem envolvimento de outros órgãos além da pele, com ótima resposta ao tratamento quimioterápico. A distinção entre LCCB primário e secundário é muito difícil de ser realizada, uma vez que eles são clínica e histopatologicamente indistinguíveis. Deve-se sempre pesquisar o acometimento de órgãos internos para então definir o prognóstico. Abstract in english Cutaneous lymphomas are classified as either type B cell or T cell lymphoma, the former type being less frequent. Cutaneous B cell lymphoma (CBCL) may be primary or secondary. The latter has a more aggressive natural history with a worse prognostic. In this paper, the authors present a secondary CBC [...] L case with a three-year evolution, indolent course, without involvement of other organs beside the skin and with optimal response to chemotherapeutic treatment. The distinction between primary and secondary CBCL is very difficult to determine insofar as they are clinically and histopathologically indistinguishable. It is always necessary to investigate whether internal organs have been affected prior to defining the prognosis.

Mariana de Gusmão, Nunes; Ana Paula Soares de Moura, Pierro; Maria Fernanda Villela, Coutinho; José Carlos Oliveira de, Morais; Sueli Coelho da Silva, Carneiro; David Rubem, Azulay.

210

Linfoma malt primario de la lengua / Primary malt limphoma of the tongue  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish Los linfomas derivados de los tejidos linfoides asociados a las mucosas (MALT) primarios de la lengua son infrecuentes. Se documenta el caso de una paciente de 80 años de edad, con un tumor en el dorso de la lengua filiado histológicamente como linfoma extranodal de células B. Se sugiere como posibl [...] e origen del linfoma un proceso reactivo de origen desconocido, al presentar las glándulas salivales menores adyacentes al tumor un cuadro compatible con una sialadenitis mioepitelial. Abstract in english Primitive malignant lymphoma mucosa associated lymphoid tissue (MALT) on the tongue are rare entities. We report here a case of an old woman (80 years old) with a tumor in the dorsum of the tongue, which was histologically diagnosed as an extra-nodal marginal B cell lymphoma. An inflammatory reactio [...] n resembling myoepithelial sialoadenitis was observed in the minor salivary glands adjacent at the tumour, suggesting a possible derivation of the lymphoma from a previous reactive process of unknown origin.

Gaia, Goteri; Giuliano, Ascani; Alessandra, Filosa; C, Corrado Rubini; Sonsoles, Olay; Paolo, Balercia.

2004-12-01

211

Linfoma cutâneo de células B: relato de caso Cutaneous B-cell lymphoma: a case report  

Directory of Open Access Journals (Sweden)

Full Text Available Os linfomas cutâneos são classificados em linfomas de células B ou de células T, sendo os primeiros menos freqüentes. O linfoma cutâneo de células B (LCCB pode ser primário ou secundário, tendo o último história natural mais agressiva, com pior prognóstico. Os autores apresentam um caso de LCCB secundário com três anos de evolução, curso indolente, sem envolvimento de outros órgãos além da pele, com ótima resposta ao tratamento quimioterápico. A distinção entre LCCB primário e secundário é muito difícil de ser realizada, uma vez que eles são clínica e histopatologicamente indistinguíveis. Deve-se sempre pesquisar o acometimento de órgãos internos para então definir o prognóstico.Cutaneous lymphomas are classified as either type B cell or T cell lymphoma, the former type being less frequent. Cutaneous B cell lymphoma (CBCL may be primary or secondary. The latter has a more aggressive natural history with a worse prognostic. In this paper, the authors present a secondary CBCL case with a three-year evolution, indolent course, without involvement of other organs beside the skin and with optimal response to chemotherapeutic treatment. The distinction between primary and secondary CBCL is very difficult to determine insofar as they are clinically and histopathologically indistinguishable. It is always necessary to investigate whether internal organs have been affected prior to defining the prognosis.

Mariana de Gusmão Nunes

2004-12-01

212

Interacción de los efectos del policosanol y el aceite de pescado sobre el tiempo de sangrado y la agregación plaquetaria intravascular en ratas  

Directory of Open Access Journals (Sweden)

Full Text Available El consumo de aceite de pescado ha mostrado reducir los eventos cardiovasculares por lo cual investigar si su administración con terapias concomitantes aporta beneficios adicionales resulta de interés. Estudios experimentales y clínicos han mostrado que la administración conjunta de aceite de pescado y policosanol muestra beneficios añadidos sobre el perfil lipídico y la agregación plaquetaria inducida ex vivo. Este trabajo investigó si la terapia combinada aceite de pescado + policosanol mostraba evidencias de interacción farmacológica sobre el tiempo de sangrado (TS y la agregación plaquetaria intravascular inducida in vivo en ratas. Las ratas se distribuyeron en siete grupos: uno control negativo tratado con vehículo al que no se le inyectó colágeno y seis grupos con agregación inducida por colágeno, uno tratado con vehículo (control positivo, uno con aceite de pescado (1 g/kg, dos tratados con policosanol (5 ó 25 mg/kg y dos con aceite de pescado (1 g/kg + policosanol (5 ó 25 mg/kg. Los tratamientos se administraron por vía oral durante cuatro semanas, al término de las cuales se determinó el TS y la agregación plaquetaria in vivo. El policosanol, el aceite de pescado y la terapia combinada inhibieron la agregación plaquetaria por colágeno, pero la terapia combinada no produjo efectos mayores que las monoterapias. Ninguna monoterapia modificó significativamente el TS, si bien la terapia combinada aumentó esta variable en una magnitud sugestiva de interacción aditiva. No se observaron manifestaciones hemorrágicas en las ratas tratadas con la terapia combinada, lo que sugiere un bajo riesgo potencial en este sentido.

Vivian Molina

2009-01-01

213

Role of intravascular ultrasound (IVUS) in determining the therapeutic strategy for the patients with intermediate coronary lesions.  

Science.gov (United States)

Background: Coronarography presents some limits in assessing intermediate stenosis. Intravascular ultrasound provides tridimensional measurements of the artery, with more reliable data guiding revascularization decision. aims: to evaluate the impact of intravascular ultrasound measurements on revascularization decision of intermediate and ambiguous coronary lesions. methods: We prospectively analysed 40 patients' coronary arteries from March 2009 to November 2011 by both quantitative coronary angiography (QCA) then intravascular ultrasound, and compared our decision before and after intravascular ultrasound. results: in the final revascularization decision after intravascular ultrasound, medical treatment rate raised from 22% to 25%, percutaneous coronary intervention dropped from 55% to 50%, and coronary artery bypass graft slightly raised from 23% to 25%. Therapeutic decision changed after intravascular ultrasound in 47% of patients (p=0,01), which reflects an important impact of this technique in management of intermediate coronary lesions. Conclusion : Intravascular ultrasound provided more accurate measurements which permitted a better detection of ischemia and influenced notably our therapeutic strategies. PMID:24955970

Ben Ahmed, H; Bouzouita, K; Boussaid, H; Hamdi, I; Aida, M; Ben Youssef, A; Boujnah, M R

2014-03-01

214

Risk stratification for indolent lymphomas Estratificação de risco dos linfomas indolentes  

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Full Text Available Indolent B-cell lymphomas account for approximately 40% of all non-Hodgkin lymphomas (NHLs. Advances in technology have contributed to improvements in the diagnosis and classification of indolent non-Hodgkin lymphomas. Follicular Lymphomas are the most common although the frequency varies significantly throughout the world. The description of the Follicular Lymphoma International Prognostic Index (FLIPI was an important step in identifying patient subgroups, but its use in the clinical practice has not been established yet. The use of a larger number of paraffin active monoclonal antibodies for immunohistochemistry, molecular cytogenetic studies including standard cytogenetics, multi-color fluorescence in-situ hybridization (FISH, polymerase chain reaction and locus-specific fluorescence insitu hybridization as well as developments in high-resolution techniquesincluding microarray gene expression profiling allow more accurate diagnosis andprecise definition of biomarkers of value in risk stratification. The identification ofdiseasespecific gene lists resulting from expression profiling provides a number ofpotential protein targets that can be validated using immunohistochemistry. Analysesof gene expression profiles or constitutive gene variations may also provide additional insight for prognostication in the near future. A comprehensive understanding of the biology of these distinct lymphoid tumors will allow us to identify novel diseaserelated genes and should facilitate the development of improved diagnosis, outcome prediction, and personalized approaches to treatment.Os linfomas de células B indolentes representam aproximadamente 40% do total de linfomas não Hodgkin (LNHs. O avanço das tecnologias novas tem contribuído para a melhora no diagnóstico e classificação dos LNH indolentes. O linfoma folicular é o mais comum e sua frequência varia significantemente pelo mundo. Adescrição do Índice Internacional de Prognóstico dos linfomas folicular (FLIPI representa um passo importante na identificação de subgrupos de pacientes, mas seu uso na prática clínica ainda necessita ser estabelecido. O uso de um número maior de anticorpos monoclonais para imunoistoquímica, estudo citogenético incluindo citogenética convencional ou hibridização in-situ por fluorescência (FISH, bem como o desenvolvimento de técnicas de alta resolução incluindo a expressão por microarray possibilita maior acurácia no diagnóstico e definição precisa dos biomarcadores com valor na estratificação de risco. A identificação de genes específicos para os diversos tipos de linfomas permite o reconhecimento de potenciais proteínas alvo que podem ser validadas usando imunoistoquímica. Análises da expressão do perfil de genes ou variações genéticas constitutivas pode também prover conhecimentos adicionais para o prognóstico em um futuro próximo. Um entendimento da biologia desses distintos tumores linfoides permite-nos identificar novos grupos de genes relacionados à doença e deve facilitar o desenvolvimento diagnóstico, predizendo a evolução e permitindo tratamentos personalizados.

Abrahão Elias Hallack Neto

2010-01-01

215

Linfoma conjuntival tipo MALT bilateral en adolescente / Bilateral Conjunctival MALT Lymphoma in an Adolescent  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Los linfomas tipo MALT primarios de conjuntiva son infrecuentes y es mucho menor la afectación conjuntival exclusiva, su bilateralidad es poco común, representan el 5% del total de los linfomas no Hodgkin extranodales; son linfomas B de bajo grado derivados de linfocitos de la zona marginal con alte [...] raciones moleculares que han bloqueado su apoptosis. Se presentó un caso de linfoma tipo MALT primario de la conjuntiva tarsal inferior de ambos ojos, en un niño de 12 años de edad, que acudió por enrojecimiento y molestias en ambos ojos de un año de evolución. Al realizar el examen físico presentó discreta ptosis del ojo izquierdo de un milímetro, masa de color anaranjada-salmón en fondo saco conjuntival inferior en ambos ojos, no adherida a planos profundos. El rayo x de órbita y la tomografía axial de cráneo no arrojó alteraciones. Se realizó hematología completa, pruebas de coagulación, bioquímica elemental y toda la analítica fue normal. El estudio anatomopatológico reportó: infiltrado linfoide denso y extenso constituido por linfocitos pequeños, algunos de aspecto plasmocitoide, sin nucléolo y sin indentación, dichos datos sugieren proliferacion linfoide maligna. Se confirmó el diagnóstico de linfoma B de bajo grado de tipo MALT. Abstract in english The primary MALT lymphomas of the conjunctiva are uncommon, the conjunctival affection is less frequent, and its bilaterality is uncommon, representing 5% of all extranodal non- Hodgkin lymphomas. Low-grade B lymphomas derived from marginal zone lymphocytes with molecular alterations are those that [...] have blocked its apoptosis. A 12 -year- old patient with primary MALT type lymphoma of the lower tarsal conjunctiva of both eyes was presented in this paper. The patient was healthy and presented redness and discomfort in both eyes in a year of evolution. The physical examination showed discrete ptosis of the left eye of a millimeter. Mass of orange - salmon color in lower conjunctival sac of both eyes, not adhered to deep planes was observed. Orbital X-ray and cranial CT were unaltered. Complete hematology, coagulation tests, and all elemental analytical biochemistry were performed, the results were normal. The pathological study reported: dense and extensive infiltrate lymphoid, composed of small lymphocytes, some without nucleolus plasmacytoid appearance without indentation, these data suggested a malignant lymphoid proliferation. The diagnosis of low-grade B-cell lymphoma of MALT type was confirmed.

Hiram Luis, Mena Estévez; Mabel Marilín, Calderín López; Deysi Mayle, Oquendo Calderín; Hiram Alejandro, Mena Calderín; Diagnis, Rodriguez Verdecia.

2014-03-01

216

Risk stratification for indolent lymphomas / Estratificação de risco dos linfomas indolentes  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese Os linfomas de células B indolentes representam aproximadamente 40% do total de linfomas não Hodgkin (LNHs). O avanço das tecnologias novas tem contribuído para a melhora no diagnóstico e classificação dos LNH indolentes. O linfoma folicular é o mais comum e sua frequência varia significantemente pe [...] lo mundo. Adescrição do Índice Internacional de Prognóstico dos linfomas folicular (FLIPI) representa um passo importante na identificação de subgrupos de pacientes, mas seu uso na prática clínica ainda necessita ser estabelecido. O uso de um número maior de anticorpos monoclonais para imunoistoquímica, estudo citogenético incluindo citogenética convencional ou hibridização in-situ por fluorescência (FISH), bem como o desenvolvimento de técnicas de alta resolução incluindo a expressão por microarray possibilita maior acurácia no diagnóstico e definição precisa dos biomarcadores com valor na estratificação de risco. A identificação de genes específicos para os diversos tipos de linfomas permite o reconhecimento de potenciais proteínas alvo que podem ser validadas usando imunoistoquímica. Análises da expressão do perfil de genes ou variações genéticas constitutivas pode também prover conhecimentos adicionais para o prognóstico em um futuro próximo. Um entendimento da biologia desses distintos tumores linfoides permite-nos identificar novos grupos de genes relacionados à doença e deve facilitar o desenvolvimento diagnóstico, predizendo a evolução e permitindo tratamentos personalizados. Abstract in english Indolent B-cell lymphomas account for approximately 40% of all non-Hodgkin lymphomas (NHLs). Advances in technology have contributed to improvements in the diagnosis and classification of indolent non-Hodgkin lymphomas. Follicular Lymphomas are the most common although the frequency varies significa [...] ntly throughout the world. The description of the Follicular Lymphoma International Prognostic Index (FLIPI) was an important step in identifying patient subgroups, but its use in the clinical practice has not been established yet. The use of a larger number of paraffin active monoclonal antibodies for immunohistochemistry, molecular cytogenetic studies including standard cytogenetics, multi-color fluorescence in-situ hybridization (FISH), polymerase chain reaction and locus-specific fluorescence insitu hybridization as well as developments in high-resolution techniquesincluding microarray gene expression profiling allow more accurate diagnosis andprecise definition of biomarkers of value in risk stratification. The identification ofdiseasespecific gene lists resulting from expression profiling provides a number ofpotential protein targets that can be validated using immunohistochemistry. Analysesof gene expression profiles or constitutive gene variations may also provide additional insight for prognostication in the near future. A comprehensive understanding of the biology of these distinct lymphoid tumors will allow us to identify novel diseaserelated genes and should facilitate the development of improved diagnosis, outcome prediction, and personalized approaches to treatment.

Abrahão Elias, Hallack Neto; Renata Oliveira, Costa; Angelo, Atalla; Frederico Luiz, Dulley; Dalton Alencar Fischer, Chamone; Juliana, Pereira.

217

Linfoma não Hodgkin primário da coluna vertebral / Primary non-Hodgkin's lymphoma of the vertebral column  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese O linfoma primário do osso (LPO) é uma condição extremamente rara, habitualmente confundida com outras lesões ósseas primárias. É responsável por cerca de 3%-5% de todos os tumores malignos no osso e 4%-7% de todos os linfomas nãoHodgkin extranodais. Caracteriza-se pelo envolvimento de um ou vários [...] locais ósseos, com ou sem comprometimento de linfonodos regionais e vísceras. Histopatologicamente, o linfoma non Hodgkin de grandes células B representa a maioria dos casos de LPO. Ossos longos são mais frequentemente comprometidos, e o fêmur é o sítio mais acometido. Osso ilíaco e da coluna vertebral também podem ser atingidos. Relatamos um caso raro de linfoma não Hodgkin da vértebra em mulher de 41 anos. A imuno-histoquímica revelou CD20 e CD45 positivos. Ela foi diagnosticada com linfoma primário difuso de grandes células B da coluna vertebral. O estudo histopatológico da medula óssea não detectou infiltração por hemopatia linfoide. A paciente foi tratada com quimioterapia CHOP juntamente com etoposide, seguida de radioterapia (dose total = 3600cGy) na região tóraco-lombar. Não houve evidência de recidiva em um período de vinte meses de acompanhamento. Abstract in english Primary bone lymphoma (PBL) is an extremely rare condition, commonly confused with other primary bone injuries. It accounts for approximately 3-5% of all malignant bone tumors and 4-7% of all extranodal non-Hodgkin's lymphomas. It is characterized by the involvement of one or multiple bone locations [...] , with or without the involvement of regional lymph nodes and viscera. Histopathologically, diffuse large-B-cell lymphomas account for the majority of cases of PBL. Long bones are usually involved, with the femur being the most commonly affected site. Pelvic bones and the vertebral column can also be involved. We report on a rare case of PLB of the vertebra in a 41-year-old woman. Immunohistochemistry examinations revealed CD20 and CD45 positive cells. She was diagnosed with primary diffuse large B-cell lymphoma presenting as a vertebral column tumor. The histopathologic analysis of the bone marrow did not show lymphoproliferative disorders. The patient was treated with a CHOP plus etoposide regimen. Systemic chemotherapy was followed by radiotherapy (total dose = 3600 cGy) in the thoracolumbar region. There was no evidence of recurrence in the 20-month follow up.

Ronald F., Pinheiro; Francisco D., Rocha Filho; Francisco V. A., Ferreira; Gabrielle G., Lima; Jacqueline H., Souza; Michelle G., Lima.

218

Linfoma conjuntival tipo MALT bilateral en adolescente / Bilateral Conjunctival MALT Lymphoma in an Adolescent  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Los linfomas tipo MALT primarios de conjuntiva son infrecuentes y es mucho menor la afectación conjuntival exclusiva, su bilateralidad es poco común, representan el 5% del total de los linfomas no Hodgkin extranodales; son linfomas B de bajo grado derivados de linfocitos de la zona marginal con alte [...] raciones moleculares que han bloqueado su apoptosis. Se presentó un caso de linfoma tipo MALT primario de la conjuntiva tarsal inferior de ambos ojos, en un niño de 12 años de edad, que acudió por enrojecimiento y molestias en ambos ojos de un año de evolución. Al realizar el examen físico presentó discreta ptosis del ojo izquierdo de un milímetro, masa de color anaranjada-salmón en fondo saco conjuntival inferior en ambos ojos, no adherida a planos profundos. El rayo x de órbita y la tomografía axial de cráneo no arrojó alteraciones. Se realizó hematología completa, pruebas de coagulación, bioquímica elemental y toda la analítica fue normal. El estudio anatomopatológico reportó: infiltrado linfoide denso y extenso constituido por linfocitos pequeños, algunos de aspecto plasmocitoide, sin nucléolo y sin indentación, dichos datos sugieren proliferacion linfoide maligna. Se confirmó el diagnóstico de linfoma B de bajo grado de tipo MALT. Abstract in english The primary MALT lymphomas of the conjunctiva are uncommon, the conjunctival affection is less frequent, and its bilaterality is uncommon, representing 5% of all extranodal non- Hodgkin lymphomas. Low-grade B lymphomas derived from marginal zone lymphocytes with molecular alterations are those that [...] have blocked its apoptosis. A 12 -year- old patient with primary MALT type lymphoma of the lower tarsal conjunctiva of both eyes was presented in this paper. The patient was healthy and presented redness and discomfort in both eyes in a year of evolution. The physical examination showed discrete ptosis of the left eye of a millimeter. Mass of orange - salmon color in lower conjunctival sac of both eyes, not adhered to deep planes was observed. Orbital X-ray and cranial CT were unaltered. Complete hematology, coagulation tests, and all elemental analytical biochemistry were performed, the results were normal. The pathological study reported: dense and extensive infiltrate lymphoid, composed of small lymphocytes, some without nucleolus plasmacytoid appearance without indentation, these data suggested a malignant lymphoid proliferation. The diagnosis of low-grade B-cell lymphoma of MALT type was confirmed.

Hiram Luis, Mena Estévez; Mabel Marilín, Calderín López; Deysi Mayle, Oquendo Calderín; Hiram Alejandro, Mena Calderín; Diagnis, Rodriguez Verdecia.

219

Hepatitis C: crioglobulinemia y linfoma no-Hodgkin / Hepatitis C: cryoglobulinemia and non-Hodgkin lymphoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish La infección por el virus de la hepatitis C juega un papel principal en la patogénesis de la crioglobulinemia mixta, promoviendo la activación y expansión de las células B. Estos reajustes moleculares inducen la síntesis de crioglobulinas y la aparición de la vasculitis crioglobulinémica. El aclaram [...] iento del virus provoca la resolución de las manifestaciones clínicas y de las alteraciones inmunológicas observados en la crioglobulinemia mixta en un alto porcentaje de los pacientes, pero no en todos. En algunos casos, la crioglobulinemia puede aparecer tras la respuesta virológica sostenida. Muchos mecanismos de la patogénesis de la crioglobulinemia mixta están fuertemente relacionados con la infección por VHC y, cuando el virus es eliminado, hay una mejoría en el curso de la enfermedad. Aun así, los pasos independientes relacionados con otros factores no mejoran tras la erradicación del virus. En algunos tipos de linfomas no-Hodgkin de bajo grado (linfoma linfoplasmocítico y linfoma de la zona marginal) la respuesta sostenida tras el aclaramiento viral induce una remisión de la neoplasia. El VHC tiene un papel secundario en los linfomas agresivos y el aclaramiento del virus puede no inducir la remisión, pero puede disminuir la hepatotoxicidad asociada a la quimioterapia. Por tanto, en la hepatitis C crónica, la combinación de interferón pegilado y ribavirina es altamente recomendable en el tratamiento de la crioglobulinemia mixta sintomática y los linfomas no-Hodgkin asociados al VHC. Abstract in english Hepatitis C virus infection plays a major role in the pathogenesis of mixed cryoglobulinemia, promoting activation and expansion of B cells. These molecular rearrangements induce synthesis of cryoglobulins and the appearance of cryoglobulinemic vasculitis. Clearance of the virus promotes resolution [...] of the clinical manifestations and immunological disorders seen in mixed cryoglobulinemia in a large percentage of patients, but not in all. In some cases, cryoglobulinemia could appear after sustained response. Several steps in the pathogenesis of mixed cryoglobulinemia are strongly related to HCV infection and when the virus is eliminated, the disease course improves. However, independent steps related to other factors do not improve following viral clearance. In some types of low-grade non-Hodgkin lymphoma (lymphomoplasmocytic lymphoma, marginal zone lymphoma) sustained response following antiviral treatment induces remission of the neoplasm. HCV has a minor role in aggressive lymphomas and clearance of the virus may not induce remission, but could decrease the hepatotoxicity associated with the chemotherapy. Therefore, in chronic hepatitis C, the combination of peginterferon + ribavirin is strongly recommended in treating symptomatic mixed cryoglobulinemia and HCV-related non-Hodgkin lymphomas.

M., Romero-Gómez; D., García-Romero.

220

Hepatitis C: crioglobulinemia y linfoma no-Hodgkin Hepatitis C: cryoglobulinemia and non-Hodgkin lymphoma  

Directory of Open Access Journals (Sweden)

Full Text Available La infección por el virus de la hepatitis C juega un papel principal en la patogénesis de la crioglobulinemia mixta, promoviendo la activación y expansión de las células B. Estos reajustes moleculares inducen la síntesis de crioglobulinas y la aparición de la vasculitis crioglobulinémica. El aclaramiento del virus provoca la resolución de las manifestaciones clínicas y de las alteraciones inmunológicas observados en la crioglobulinemia mixta en un alto porcentaje de los pacientes, pero no en todos. En algunos casos, la crioglobulinemia puede aparecer tras la respuesta virológica sostenida. Muchos mecanismos de la patogénesis de la crioglobulinemia mixta están fuertemente relacionados con la infección por VHC y, cuando el virus es eliminado, hay una mejoría en el curso de la enfermedad. Aun así, los pasos independientes relacionados con otros factores no mejoran tras la erradicación del virus. En algunos tipos de linfomas no-Hodgkin de bajo grado (linfoma linfoplasmocítico y linfoma de la zona marginal la respuesta sostenida tras el aclaramiento viral induce una remisión de la neoplasia. El VHC tiene un papel secundario en los linfomas agresivos y el aclaramiento del virus puede no inducir la remisión, pero puede disminuir la hepatotoxicidad asociada a la quimioterapia. Por tanto, en la hepatitis C crónica, la combinación de interferón pegilado y ribavirina es altamente recomendable en el tratamiento de la crioglobulinemia mixta sintomática y los linfomas no-Hodgkin asociados al VHC.Hepatitis C virus infection plays a major role in the pathogenesis of mixed cryoglobulinemia, promoting activation and expansion of B cells. These molecular rearrangements induce synthesis of cryoglobulins and the appearance of cryoglobulinemic vasculitis. Clearance of the virus promotes resolution of the clinical manifestations and immunological disorders seen in mixed cryoglobulinemia in a large percentage of patients, but not in all. In some cases, cryoglobulinemia could appear after sustained response. Several steps in the pathogenesis of mixed cryoglobulinemia are strongly related to HCV infection and when the virus is eliminated, the disease course improves. However, independent steps related to other factors do not improve following viral clearance. In some types of low-grade non-Hodgkin lymphoma (lymphomoplasmocytic lymphoma, marginal zone lymphoma sustained response following antiviral treatment induces remission of the neoplasm. HCV has a minor role in aggressive lymphomas and clearance of the virus may not induce remission, but could decrease the hepatotoxicity associated with the chemotherapy. Therefore, in chronic hepatitis C, the combination of peginterferon + ribavirin is strongly recommended in treating symptomatic mixed cryoglobulinemia and HCV-related non-Hodgkin lymphomas.

M. Romero-Gómez

2008-03-01

 
 
 
 
221

Disseminated intravascular coagulation in an ambulatory young woman.  

Science.gov (United States)

We are reporting the case of an ambulatory young woman with a 10-year history of recurrent venous thrombosis who presented to us with diffuse intravascular coagulation (DIC). After excluding the recognized causes of DIC, we examined the possibility that her clinically quiescent ulcerative colitis might be the underlying stimulus. We documented sepsis-range endotoxemia in this patient at a time when she was afebrile and had a normal C-reactive protein level. In vitro her serum upregulated tissue factor in cultured endothelial cells. We postulate that she had become tolerant to the systemic effects of endotoxin leaking from her inflamed colon but that the endotoxin stimulated her endothelium and/or monocytes to produce tissue factor that made her intensely hypercoagulable. Her prothrombotic state may have been compounded by the fact that she was heterozygous for prothrombin G20210A and that her plasma clotting time demonstrated resistance to activated protein C. PMID:16131459

Aue, Georg; Carroll, Nancy; Kressel, Bruce R; Hardi, Robert; Horne, McDonald K

2005-09-01

222

[Kidney donor with severe disseminated intravascular coagulation: transplantation however successful].  

Science.gov (United States)

A 41-year-old male, with no previous medical history, was admitted to our intensive care unit with severe isolated neurotrauma and a Glasgow Coma Scale of E1-M1-V1, mid-dilated unreactive pupils and severe abnormalities on the brain CT-scan. A severe syndrome of disseminated intravascular coagulation (DIC) and non-oliguric renal insufficiency developed. Following clinical and neurophysiological examination the patient was declared brain-dead, and the family gave permission for organ donation. The left kidney was transplanted and functioned well immediately. However, in view of the DIC and renal function disorders the right kidney was not considered usable for transplantation elsewhere. Pathological examination revealed many fibrin thrombi in the glomerular capillaries and acute tubular necrosis. This case supports the view that thrombotic microangiopathy in kidneys of patients with DIS, even with renal function impairment, is not an a priori reason for excluding donation. PMID:19857287

Keeris, Lodewijk M; Bergmans, Dennis C J J; van der Sande, Frank M; Wind, Tineke J; van Suylen, Robert Jan; van Mook, Walther N K A

2009-01-01

223

Evaluation of Disseminated Intravascular Coagulation in the Craniocerebral Traumas  

Directory of Open Access Journals (Sweden)

Full Text Available Traumatic injury is one of the most important cause of disseminated intravascular coagulation (DIC. It occurs because of blood loss and hemodilution due to fluid resuscitation. The incidence of trauma associated DIC is mainly higher in the craniocerebral traumas. Even though craniocerebral trauma related DIC is well defined, the pathophysiology has been poorly characterized in the literature. Due to the fact that brain tissue is highly significant for procoagulant molecules, craniocerebral traumas are closely related to DIC. In the current study, 30 patients admitted to emergency room have been considered on the first and fifth day of admission to the hospital for the coagulation tests to evaluate DIC in both two groups. [Cukurova Med J 2014; 39(3.000: 488-495

Faruk Altinel

2014-06-01

224

Synthetic aperture-based beam compression for intravascular ultrasound imaging.  

Science.gov (United States)

In this paper, intravascular ultrasound (IVUS) images acquired with a 64-element array transducer using a multistatic acquisition scheme are presented. The images are reconstructed from a collection of pulse-echo measurements using a synthetic aperture array imaging technique. The main limitations of IVUS imaging are a poor lateral resolution and elevated grating lobes caused by the imaging geometry. We propose a Synthetic Aperture Focusing Technique (SAFT), which uses a limited number of A-scan signals. The focusing process, which is performed in the Fourier domain, requires far less computation time than conventional delay-and-sum methods. Two different reconstruction kernel functions have been derived and are compared for the processing of experimental data. PMID:11367787

Vray, D; Haas, C; Rastello, T; Krueger, M; Brusseau, E; Schroeder, K; Gimenez, G; Ermert, H

2001-01-01

225

Primary cutaneous centrofollicular lymphoma with a good response to radiotherapy / Linfoma centrofolicular cutâneo primário com boa resposta a radioterapia  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese Os linfomas cutâneos primários têm comportamento clínico e prognóstico diferente dos linfomas sistêmicos de subtipo histológico semelhante. Cerca de 30% dos linfomas não-Hodgkin acometem tecidos extranodais, sendo a pele o segundo órgão mais envolvido após o trato gastrointestinal (aproximadamente 1 [...] 8%). De acordo com a classificação EORTC (European Organization for Research and Treatment of Cancer), o linfoma centrofolicular cutâneo é indolente, uma vez que as lesões aumentam de tamanho lentamente ao longo dos anos e a disseminação para sitios extracutâneos é incomum. Com base nisso, a radioterapia tem sido apontada como o tratamento de primeira escolha por muitos estudos. Apresentamos um caso de paciente com linfoma cutâneo centrofolicular no couro cabeludo há 1 ano e que apresentou boa resposta à radioterapia. Abstract in english Primary cutaneous lymphomas have different clinical behavior and prognosis than systemic lymphomas of similar histological subtype. About 30% of non-Hodgkin lymphomas involve extranodal tissues, the skin being the second most affected body organ after the gastrointestinal tract (approximately 18%). [...] According to the EORTC (European Organization for Research and Treatment of Cancer) classification, the lymphoma centrofollicular is indolent, since the lesions increase in size slowly over the years and spread to extracutaneous sites is uncommon. Based on this, radiotherapy has been considered the treatment of choice by many studies. We present the case of a patient who had cutaneous centrofollicular scalp lymphoma for 1 year and showed good response to radiotherapy.

Cláudia Medeiros dos Santos, Camargo; Lislaine, Bomm; Leonardo Spagnol, Abraham; Rafael, Daher; Maria de Fátima Guimarães, Scotelaro; Luna Azulay, Abulafia.

226

Primary cutaneous centrofollicular lymphoma with a good response to radiotherapy / Linfoma centrofolicular cutâneo primário com boa resposta a radioterapia  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese Os linfomas cutâneos primários têm comportamento clínico e prognóstico diferente dos linfomas sistêmicos de subtipo histológico semelhante. Cerca de 30% dos linfomas não-Hodgkin acometem tecidos extranodais, sendo a pele o segundo órgão mais envolvido após o trato gastrointestinal (aproximadamente 1 [...] 8%). De acordo com a classificação EORTC (European Organization for Research and Treatment of Cancer), o linfoma centrofolicular cutâneo é indolente, uma vez que as lesões aumentam de tamanho lentamente ao longo dos anos e a disseminação para sitios extracutâneos é incomum. Com base nisso, a radioterapia tem sido apontada como o tratamento de primeira escolha por muitos estudos. Apresentamos um caso de paciente com linfoma cutâneo centrofolicular no couro cabeludo há 1 ano e que apresentou boa resposta à radioterapia. Abstract in english Primary cutaneous lymphomas have different clinical behavior and prognosis than systemic lymphomas of similar histological subtype. About 30% of non-Hodgkin lymphomas involve extranodal tissues, the skin being the second most affected body organ after the gastrointestinal tract (approximately 18%). [...] According to the EORTC (European Organization for Research and Treatment of Cancer) classification, the lymphoma centrofollicular is indolent, since the lesions increase in size slowly over the years and spread to extracutaneous sites is uncommon. Based on this, radiotherapy has been considered the treatment of choice by many studies. We present the case of a patient who had cutaneous centrofollicular scalp lymphoma for 1 year and showed good response to radiotherapy.

Cláudia Medeiros dos Santos, Camargo; Lislaine, Bomm; Leonardo Spagnol, Abraham; Rafael, Daher; Maria de Fátima Guimarães, Scotelaro; Luna Azulay, Abulafia.

2013-12-01

227

Burkitt-like lymphoma in an infant: a case report / Linfoma burkitt-like em um lactente: relato de caso  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese Os linfomas não Hodgkin da infância, incluindo os linfomas de Burkitt e Burkitt-like são raros em lactentes. Um caso de linfoma não Hodgkin B em uma lactente de 13 meses de idade é descrito. Ao diagnóstico a paciente apresentava extenso comprometimento abdominal associado à ascite, derrame pleural e [...] síndrome de lise tumoral. A análise imunofenotípica mostrou um fenótipo compatível com células linfóides oriundas do centro germinativo e a origem clonal dessas células foi demonstrada por reação em cadeia da polimerase. Não foi demonstrada associação do linfoma com infecção pelo vírus Epstein-Barr e/ou virus da imunodeficiência adquirida. O caso apresentado enfatiza a necessidade de considerar o diagnóstico de linfoma mesmo em lactentes. Abstract in english Childhood non-Hodgkin's lymphomas, including Burkitt and Burkitt-like, are rarely diagnosed in infants. A case of B-cell lymphoma in a 13-month-old girl with extensive abdominal disease, ascites, pleural effusion, and tumor lysis syndrome is reported. Phenotypic analysis showed a germinal center B-c [...] ell phenotype, and a B-cell clonality was confirmed by polymerase chain reaction. There was no evidence of Epstein-Barr and HIV infection. The case herein reported emphasizes the need for considering the diagnosis of lymphoma even in very young children.

Claudete Esteves, Klumb; Lídia Maria Magalhães de, Resende; Claudio Gustavo, Stefanoff; Carlos Humberto, Vicuña; Ilana Zalcberg, Renault; Raquel Ciuvalschi, Maia.

228

Intravascular Fiberoptic Detection Of D2O Concentration In Blood.  

Science.gov (United States)

The recent development of low-loss infrared zirconium fluoride fibers allows remote sensing of infrared signals. In this paper a detection device for the intravascular measurement of substances absorbing in the infrared wave length range is described. The applicability of the technique is demonstrated by the measurement of small concentrations of heavy water (D20) in blood. The method is based on the well-known fact that D20 strongly absorbes radiation in the 4 ?m range while H2O and blood are comparably well transmitted at that wave length. A catheter was designed that can be inserted in arterial blood vessels. The catheter tip is constructed such that the radiation is guided by the fiber to a gold reflector. Between the reflector and the fiber, blood is withdrawn through a gap of ca. 0.1 mm. The radiation thus passes the medium twice and is guided back to the same fiber. Concentrations below 1 ml D20/1000 ml blood can be determined accurately and indicator kinetics can be recorded with time constants of the entire system below 0.05 s. The advantages of this technique are the low withdrawal rate and neglectable delay of the recorded indicator kinetics and no need for reinfusion of blood. D20 has been used to determine physiological parameters such as extravascular lung water, cardiac output and total body water. The study demonstrates that such measurements are feasable with the described fiberoptic device and that the fiberoptic approach offers distinct advantages over conventional blood withdrawal methods with external analysis. Injectate volumes as small as 0.05 ml/kg body weight are sufficient to obtain indicator kinetics with acceptable signal to noise ratio. By use of appropriate filters concentrations of other substances and their intravascular kinetics can be measured. According to their physicochemical properties a variety of information on physiological parameters appears to be accessible with this approach.

Bock, J.; Gersing, E.; Sundmacher, F.; Hellige, G.

1988-06-01

229

O Tratado de Roma: a "relíquia" da construção europeia  

Digital Repository Infrastructure Vision for European Research (DRIVER)

O Tratado de Roma permitiu alterar de forma duradoura o quadro de relacionamento entre os países da Europa ocidental e, no termo da Guerra-Fria, criar um quadro de referência que orientou a transição para a democracia dos países de leste, bem como a evolução para uma economia de mercado. Tendo em conta a posição única que o Tratado de Roma ocupa no processo de construção europeia, o paper começa por enquadrar os acontecimentos que determinaram a formação das Comunidades Europei...

Soares, Anto?nio Goucha

2009-01-01

230

Radionuclide assessment of peripheral intravascular capacity: a technique to measure intravascular volume changes in the capacitance circulation in man  

International Nuclear Information System (INIS)

Changes in the capacitance vasculature influence venous return and cardiac performance, so an understanding of the effects of pathophysiologic states on the human capacitance vasculature is necessary to understand integrated cardiovascular function in man. Techniques available to assess the capacitance vasculature in man, however, have limitations. We performed radionuclide imaging of the calf or forearm in 51 patients whose erythrocytes had been labeled in vivo with technetium-99m, basing our approach on the principle that counts from the radiolabeled intravascular space are proportional to blood volume. Two-minute or 15-second count acquisitions were obtained from the calf in 42 patients. Counts obtained at rest demonstrated little variation. With veno-occlusion at 15 and 30 mm Hg, counts increased 8 +- 1% (+- SEM) (p < 0.001) and 28 +- 2% (p < 0.001), respectively. After 0.4 mg of sublingual nitroglycerin, counts increased 9 +- 1% (p < 0.001). With leg elevation, counts decreased 34 +- 4% (p < 0.001). Response patterns were similar with 2-minute and 15-second acquisitions. In nine patients who underwent forearm imaging (2-minute acquisitions), counts increased 14 + 2% (p < 0.001) and 26 +- 4% (p < 0.001) at 15- and 30-mm Hg veno-occlusion and 15 +- 3% (p < 0.001) after nitroglycerin. Volume displacements, recorded simultaneously with a fluid-filled plethysmograph about the contralateral forearm, correlated linearly in all nine patients. Thus, gamma camera imaging of the radiolabeled peripheral intravascular space provides a quantitative and reliable assessment of peripheral vascular capacity in man. The technique could be used in conjunction with gated cardiac imaging in order to assess the interactions of peripheral vascular capacity and ventricular performance

231

The use of recombinant factor VIIa in a pediatric septic shock patient with disseminated intravascular coagulation  

Directory of Open Access Journals (Sweden)

Full Text Available This is a report on a pediatric patient with septic shock and disseminated intravascular coagulation, who developed life-threatening bleeding which was successfully treated with recombinant factor VIIa.

Ronaldo Arkader

2008-03-01

232

Linfoma de colo de útero: achados na ressonância magnética / Lymphoma of uterine cervix: magnetic resonance imaging findings  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Linfoma de colo uterino é uma doença rara. Cerca de 1,0% a 1,5% dos linfomas extranodais se origina no trato genital feminino. A apresentação clínica é inespecífica e a ressonância magnética é importante para a suspeita diagnóstica. Neste artigo relatamos o caso de uma paciente de 80 anos de idade c [...] om dor lombar, cuja ressonância mostrou volumosa massa uterina. O diagnóstico final foi de linfoma. Abstract in english Lymphoma of the cervix is a rare disease. About 1.0% to 1.5% of extranodal lymphomas originates in the female genital tract. The clinical presentation of this condition is nonspecific and magnetic resonance imaging is important for diagnostic elucidation. The present report describes the case of a 8 [...] 0-year-old patient with lumbar pain, whose magnetic resonance imaging showed a large uterine mass. The final diagnosis was lymphoma.

Daniel, Kanaan; Daniella Braz, Parente; Carolina Pesce Lamas, Constantino; Rodrigo Canellas de, Souza.

233

The Incidence of Intravascular Needle Entrance during Inferior Alveolar Nerve Block Injection  

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Full Text Available

Background and aims. Dentists administer thousands of local anesthetic injections every day. Injection to a highly vascular area such as pterygomandibular space during an inferior alveolar nerve block has a high risk of intravascular needle entrance. Accidental intravascular injection of local anesthetic agent with vasoconstrictor may result in cardiovascular and central nervous system toxicity, as well as tachycardia and hypertension. There are reports that indicate aspiration is not performed in every injection. The aim of the present study was to assess the incidence of intravascular needle entrance in inferior alveolar nerve block injections.

Materials and methods. Three experienced oral and maxillofacial surgeons performed 359 inferior alveolar nerve block injections using direct or indirect techniques, and reported the results of aspiration. Aspirable syringes and 27 gauge long needles were used, and the method of aspiration was similar in all cases. Data were analyzed using t-test.

Results. 15.3% of inferior alveolar nerve block injections were aspiration positive. Intravascular needle entrance was seen in 14.2% of cases using direct and 23.3% of cases using indirect block injection techniques. Of all injections, 15.8% were intravascular on the right side and 14.8% were intravascular on the left. There were no statistically significant differences between direct or indirect block injection techniques (P = 0.127 and between right and left injection sites (P = 0.778.

Conclusion. According to our findings, the incidence of intravascular needle entrance during inferior alveolar nerve block injection was relatively high. It seems that technique and maneuver of injection have no considerable effect in incidence of intravascular needle entrance.

Sara Pourshahidi

2008-04-01

234

Leucemia/linfoma de células T do adulto Adult T-cell leukemia/lymphoma  

Directory of Open Access Journals (Sweden)

Full Text Available A leucemia/linfoma de células T do adulto (ATL é tipo agressivo de doença linfoproliferativa causada pelo vírus linfotrópico para células T humanas (HTLV-I, geralmente fatal e que não responde a quimioterapia. Classifica-se em formas aguda, crônica, linfomatosa e indolente (smoldering. Outra forma clínica, a tumoral primária de pele, com características diferentes, foi sugerida recentemente. As formas aguda, linfomatosa e tumoral primária de pele são as de pior prognóstico. Os critérios diagnósticos de ATL são: sorologia positiva para o HTLV-I; diagnóstico citológico ou histológico de leucemia/linfoma de células T, CD4+/CD25+; presença de linfócitos T anormais em sangue periférico; confirmação de integração monoclonal do DNA proviral do HTLV-I. Há lesões de pele em cerca de 70% dos casos,que podem ser primários (formas indolente e tumoral primária da pele ou secundários. As lesões cutâneas são múltiplas, sendo as mais freqüentes a eritrodermia, as pápulas e as placas. A ATL não tem aspecto histológico característico, podendo apresentar padrões superponíveis ao linfoma periférico T não especificado, à micose fungóide ou ao linfoma anaplásico de grandes células. O padrão imuno-histoquímico pode também simular o de outros tipos de linfoma T. Por esse motivo, é muito importante que no Brasil seja solicitada sorologia para o HTLV-I em todos os casos de leucemia e/ou linfoma de células T maduras.Adult T cell leukemia/lymphoma (ATL is an aggressive type of lymphoproliferative disease associated with the human T-cell lymphotropic virus type I (HTLV-I that is characterized by a short survival time and absence of response to chemotherapy. ATL is classified into four clinical types: acute, chronic, lymphoma, and smoldering. Another clinical form of ATL, the primary cutaneous tumoral,with diverse characteristics, has been recently suggested. Patients with acute, lymphoma and primary cutaneous tumoral types have a poor prognosis. The diagnostic criteria of ATL consist of: positive serology for HTLV-I; cytologic or histologic confirmation of CD4+/CD25+ T-cell leukemia/lymphoma; abnormal T lymphocytes in peripheral blood; and confirmation of monoclonal integration of HTLV-I proviral DNA. There is skin involvement in around 70% of ATL cases, which could be primary (smoldering and primary cutaneous tumoral or secondary. The skin lesions are multiple, erythroderma, papules and plaques being the most common. ATL has no characteristic histological pattern, and may present patterns that could superimpose nonspecific peripheral T-cell lymphoma, mycosis fungoides or anaplastic large cell lymphoma. The immunohistochemistry pattern may also be similar to that of other T-cell lymphomas. Thus, it is very important that in Brazil HTLV-I infection be investigated in all mature T-cell leukemias/lymphomas.

Achiléa L. Bittencourt

2008-08-01

235

Leucemia/linfoma de células T do adulto / Adult T-cell leukemia/lymphoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese A leucemia/linfoma de células T do adulto (ATL) é tipo agressivo de doença linfoproliferativa causada pelo vírus linfotrópico para células T humanas (HTLV-I), geralmente fatal e que não responde a quimioterapia. Classifica-se em formas aguda, crônica, linfomatosa e indolente (smoldering). Outra form [...] a clínica, a tumoral primária de pele, com características diferentes, foi sugerida recentemente. As formas aguda, linfomatosa e tumoral primária de pele são as de pior prognóstico. Os critérios diagnósticos de ATL são: sorologia positiva para o HTLV-I; diagnóstico citológico ou histológico de leucemia/linfoma de células T, CD4+/CD25+; presença de linfócitos T anormais em sangue periférico; confirmação de integração monoclonal do DNA proviral do HTLV-I. Há lesões de pele em cerca de 70% dos casos,que podem ser primários (formas indolente e tumoral primária da pele) ou secundários. As lesões cutâneas são múltiplas, sendo as mais freqüentes a eritrodermia, as pápulas e as placas. A ATL não tem aspecto histológico característico, podendo apresentar padrões superponíveis ao linfoma periférico T não especificado, à micose fungóide ou ao linfoma anaplásico de grandes células. O padrão imuno-histoquímico pode também simular o de outros tipos de linfoma T. Por esse motivo, é muito importante que no Brasil seja solicitada sorologia para o HTLV-I em todos os casos de leucemia e/ou linfoma de células T maduras. Abstract in english Adult T cell leukemia/lymphoma (ATL) is an aggressive type of lymphoproliferative disease associated with the human T-cell lymphotropic virus type I (HTLV-I) that is characterized by a short survival time and absence of response to chemotherapy. ATL is classified into four clinical types: acute, chr [...] onic, lymphoma, and smoldering. Another clinical form of ATL, the primary cutaneous tumoral,with diverse characteristics, has been recently suggested. Patients with acute, lymphoma and primary cutaneous tumoral types have a poor prognosis. The diagnostic criteria of ATL consist of: positive serology for HTLV-I; cytologic or histologic confirmation of CD4+/CD25+ T-cell leukemia/lymphoma; abnormal T lymphocytes in peripheral blood; and confirmation of monoclonal integration of HTLV-I proviral DNA. There is skin involvement in around 70% of ATL cases, which could be primary (smoldering and primary cutaneous tumoral) or secondary. The skin lesions are multiple, erythroderma, papules and plaques being the most common. ATL has no characteristic histological pattern, and may present patterns that could superimpose nonspecific peripheral T-cell lymphoma, mycosis fungoides or anaplastic large cell lymphoma. The immunohistochemistry pattern may also be similar to that of other T-cell lymphomas. Thus, it is very important that in Brazil HTLV-I infection be investigated in all mature T-cell leukemias/lymphomas.

Achiléa L., Bittencourt; Lourdes, Farré.

236

Linfoma leptomeníngeo en un niño con infección por el virus de la inmunodeficiencia humana  

Scientific Electronic Library Online (English)

Full Text Available SciELO Argentina | Language: Spanish Abstract in spanish El linfoma primario del sistema nervioso central en pacientes pediátricos VIH positivos es poco frecuente. Se presenta un paciente, de siete años de edad, de sexo masculino, con síndrome de inmunodeficiencia adquirida, que desarrolló un linfoma de células B con localización leptomeníngea. El niño in [...] ició el cuadro con síntomas de alteración del sensorio, hipertensión endocraneana y amaurosis bilateral. El diagnóstico se efectuó por biopsia cerebral, inmunofenotipo de las células B del líquido cefalorraquídeo, además de PCR positiva para virus de Epstein Barr en el líquido. Realizó tratamiento con quimioterapia intratecal y sistémica. Mejoraron los síntomas durante quince meses y luego recidivó en la región talámica. Cumplió radioterapia craneoespinal y falleció cuatro meses después de la recidiva. En este artículo se realiza una revisión de la bibliografía sobre esta enfermedad, señalando el carácter excepcional de este paciente por tratarse de un linfoma localizado en forma exclusiva en el sistema nervioso central y, más precisamente, en la leptomeninges. Abstract in english Primary non-Hodgkin lymphoma in the central nervous system is rare in children and in AIDS pediatric patients. We report a seven years old boy, HIV-positive, C3 stage, who developed a non- Hodgkin lymphoma in the central nervous system, with leptomeningeal location. The patient started with signs an [...] d symptoms related to increased intracranial pressure, his conscience worsened and he became blind. The diagnosis was made through brain biopsy, immunophenotype of B cells in cerebrospinal fluid, and PCR for Epstein Barr virus in the fluid. The boy was treated with intrathecal and systemic chemotherapy. His condition improved during fifteen months, and then he presented a talamic relapse. He was treated with radiotherapy and finally died four months later. In this article we review the literature about this disease, pointing to the exceptional nature of this patient because of his lymphoma exclusively located in the central nervous system, specifically leptomeningeal.

Adriana, Scrigni; Mariana, Nastri; Susana, Rodríguez de Schiavi; Liliana, Czornyj; María, Felice; Beatriz, Mantese.

237

Linfoma cerebral en paciente postrasplante renal / Primary brain lymphoma in a patient after renal transplantation  

Scientific Electronic Library Online (English)

Full Text Available SciELO Colombia | Language: Spanish Abstract in spanish El linfoma primario del sistema nervioso central (LPSNC) ha tenido un aumento en la incidencia en los últimos 40 años asociado con estados de inmunosupresión, principalmente en pacientes infectados con el virus de inmunodeficiencia humana (VIH) y con trasplante de órganos. La tumorogénesis se relaci [...] ona con el virus de Epstein Barr (VEB). El inmunofenotipo más frecuente es el linfoma de células B. Las manifestaciones clínicas son dependientes de la localización de la masa tumoral, principalmente trastornos del comportamiento y síndrome de hipertensión endocraneana. El diagnóstico diferencial etiológico se hace con procesos infecciosos, enfermedad cerebrovascular (ECV), tumores primarios gliales del sistema nervioso central y metástasis cerebrales. Al diagnóstico se llega a través de imágenes diagnósticas principalmente resonancia magnética (RM ) cerebral y con estudio histopatológico. Es importante descartar infección por VIH al hacerse diagnóstico de LPSNC. En esta revisión reportamos un linfoma primario del SNC en una paciente con antecedente de trasplante renal por enfermedad poliquística ocho años antes. Abstract in english The incidence of primary central nervous system lymphoma (PCNSL) has increased during the past 40 years. This has been associated with immunodeficiency, mainly in patients infected with the human immunodeficiency virus (HIV) and in transplant patients. Tumor genesis is related with the Epstein-Barr [...] virus (EBV). The most frequent PCNSL immunophenotype is B-cell lymphoma. Clinical manifestations depend on tumor localization, and are usually behavior dysfunctions and intracranial hypertension syndrome. Differential diagnosis must take into consideration infectious processes, stroke, primary brain tumors, and metastases. The diagnosis of PCNSL requires brain MRI and brain biopsy. It is important to assess HIV infection when diagnosing PCNSL. This review reports a case of primary brain lymphoma in a patient who underwent renal transplantation due to polycystic kidney disease 8 years before.

Carlos, Arteaga; Mónica, Duarte; Hernán, Bayona; Rafael, Andrade; Rocío, López; Sonia, Bermúdez.

2009-03-01

238

Linfoma leptomeníngeo en un niño con infección por el virus de la inmunodeficiencia humana  

Scientific Electronic Library Online (English)

Full Text Available SciELO Argentina | Language: Spanish Abstract in spanish El linfoma primario del sistema nervioso central en pacientes pediátricos VIH positivos es poco frecuente. Se presenta un paciente, de siete años de edad, de sexo masculino, con síndrome de inmunodeficiencia adquirida, que desarrolló un linfoma de células B con localización leptomeníngea. El niño in [...] ició el cuadro con síntomas de alteración del sensorio, hipertensión endocraneana y amaurosis bilateral. El diagnóstico se efectuó por biopsia cerebral, inmunofenotipo de las células B del líquido cefalorraquídeo, además de PCR positiva para virus de Epstein Barr en el líquido. Realizó tratamiento con quimioterapia intratecal y sistémica. Mejoraron los síntomas durante quince meses y luego recidivó en la región talámica. Cumplió radioterapia craneoespinal y falleció cuatro meses después de la recidiva. En este artículo se realiza una revisión de la bibliografía sobre esta enfermedad, señalando el carácter excepcional de este paciente por tratarse de un linfoma localizado en forma exclusiva en el sistema nervioso central y, más precisamente, en la leptomeninges. Abstract in english Primary non-Hodgkin lymphoma in the central nervous system is rare in children and in AIDS pediatric patients. We report a seven years old boy, HIV-positive, C3 stage, who developed a non- Hodgkin lymphoma in the central nervous system, with leptomeningeal location. The patient started with signs an [...] d symptoms related to increased intracranial pressure, his conscience worsened and he became blind. The diagnosis was made through brain biopsy, immunophenotype of B cells in cerebrospinal fluid, and PCR for Epstein Barr virus in the fluid. The boy was treated with intrathecal and systemic chemotherapy. His condition improved during fifteen months, and then he presented a talamic relapse. He was treated with radiotherapy and finally died four months later. In this article we review the literature about this disease, pointing to the exceptional nature of this patient because of his lymphoma exclusively located in the central nervous system, specifically leptomeningeal.

Adriana, Scrigni; Mariana, Nastri; Susana, Rodríguez de Schiavi; Liliana, Czornyj; María, Felice; Beatriz, Mantese.

2004-10-01

239

Linfoma cerebral en paciente postrasplante renal / Primary brain lymphoma in a patient after renal transplantation  

Scientific Electronic Library Online (English)

Full Text Available SciELO Colombia | Language: Spanish Abstract in spanish El linfoma primario del sistema nervioso central (LPSNC) ha tenido un aumento en la incidencia en los últimos 40 años asociado con estados de inmunosupresión, principalmente en pacientes infectados con el virus de inmunodeficiencia humana (VIH) y con trasplante de órganos. La tumorogénesis se relaci [...] ona con el virus de Epstein Barr (VEB). El inmunofenotipo más frecuente es el linfoma de células B. Las manifestaciones clínicas son dependientes de la localización de la masa tumoral, principalmente trastornos del comportamiento y síndrome de hipertensión endocraneana. El diagnóstico diferencial etiológico se hace con procesos infecciosos, enfermedad cerebrovascular (ECV), tumores primarios gliales del sistema nervioso central y metástasis cerebrales. Al diagnóstico se llega a través de imágenes diagnósticas principalmente resonancia magnética (RM ) cerebral y con estudio histopatológico. Es importante descartar infección por VIH al hacerse diagnóstico de LPSNC. En esta revisión reportamos un linfoma primario del SNC en una paciente con antecedente de trasplante renal por enfermedad poliquística ocho años antes. Abstract in english The incidence of primary central nervous system lymphoma (PCNSL) has increased during the past 40 years. This has been associated with immunodeficiency, mainly in patients infected with the human immunodeficiency virus (HIV) and in transplant patients. Tumor genesis is related with the Epstein-Barr [...] virus (EBV). The most frequent PCNSL immunophenotype is B-cell lymphoma. Clinical manifestations depend on tumor localization, and are usually behavior dysfunctions and intracranial hypertension syndrome. Differential diagnosis must take into consideration infectious processes, stroke, primary brain tumors, and metastases. The diagnosis of PCNSL requires brain MRI and brain biopsy. It is important to assess HIV infection when diagnosing PCNSL. This review reports a case of primary brain lymphoma in a patient who underwent renal transplantation due to polycystic kidney disease 8 years before.

Carlos, Arteaga; Mónica, Duarte; Hernán, Bayona; Rafael, Andrade; Rocío, López; Sonia, Bermúdez.

240

Linfoma difuso primario de hígado: Presentación de un caso / Diffuse primary hepatic lymphoma: Case report  

Scientific Electronic Library Online (English)

Full Text Available SciELO Argentina | Language: Spanish Abstract in spanish El linfoma primario de hígado (LPH) es un tumor raro y representa menos del 1% de los linfomas no Hodgkin extranodales de células B. Se reporta un caso de LPH en un paciente de sexo masculino de 32 años de edad, sin enfermedad hepática crónica, que ingresa a nuestra institución por sospecha de síndr [...] ome mononucleósico. La serología para Virus Epstein Barr fue positiva. Se observó mediante ecografía hepatoesplenomegalia con parénquima hepático heterogéneo en forma difusa. La RM demostró hepatoesplenomegalia y alteraciones en lóbulo derecho hepático, compatibles con infiltración linfoproliferativa. Se realizó biopsia hepática con guía ecográfica y el estudio histopatológico reveló un linfoma no Hodgkin difuso de células grandes con inmunofenotipo B. Se presentan las características clínicas y patológicas del caso, así como una revisión de los aspectos clínicos, hallazgos patológicos y radiológicos. Abstract in english Primary hepatic lymphoma (PHL) is a rare tumor that represents less than 1% of extranodal non-Hodgkin B-cell lymphoma. We report a case of PHL in a 32 year-old male patient without chronic liver disease, who was admitted into our institution for suspected mononucleosis syndrome. Serology for Epstein [...] -Barr virus was positive. Ultrasound revealed hepatosplenomegaly with diffuse heterogeneous liver parenchyma. The MRI showed hepatosplenomegaly and alterations in the right lobe of the liver compatible with lymphoproliferative infiltration. Liver biopsy was performed under ultrasound guidance, and histopathologic examination revealed a diffuse non-Hodgkin lymphoma of large cells with immunophenotype B. A clinical and a pathological case as well as a review of the clinical, pathological and radiological findings of this disease are presented.

Silvana I., Romero Vidomlansky; Ana Julia, Nielsen; Juan Cruz, Gallo; Shigeru, Kozima.

 
 
 
 
241

Linfoma difuso primario de hígado: Presentación de un caso Diffuse primary hepatic lymphoma: Case report  

Directory of Open Access Journals (Sweden)

Full Text Available El linfoma primario de hígado (LPH es un tumor raro y representa menos del 1% de los linfomas no Hodgkin extranodales de células B. Se reporta un caso de LPH en un paciente de sexo masculino de 32 años de edad, sin enfermedad hepática crónica, que ingresa a nuestra institución por sospecha de síndrome mononucleósico. La serología para Virus Epstein Barr fue positiva. Se observó mediante ecografía hepatoesplenomegalia con parénquima hepático heterogéneo en forma difusa. La RM demostró hepatoesplenomegalia y alteraciones en lóbulo derecho hepático, compatibles con infiltración linfoproliferativa. Se realizó biopsia hepática con guía ecográfica y el estudio histopatológico reveló un linfoma no Hodgkin difuso de células grandes con inmunofenotipo B. Se presentan las características clínicas y patológicas del caso, así como una revisión de los aspectos clínicos, hallazgos patológicos y radiológicos.Primary hepatic lymphoma (PHL is a rare tumor that represents less than 1% of extranodal non-Hodgkin B-cell lymphoma. We report a case of PHL in a 32 year-old male patient without chronic liver disease, who was admitted into our institution for suspected mononucleosis syndrome. Serology for Epstein-Barr virus was positive. Ultrasound revealed hepatosplenomegaly with diffuse heterogeneous liver parenchyma. The MRI showed hepatosplenomegaly and alterations in the right lobe of the liver compatible with lymphoproliferative infiltration. Liver biopsy was performed under ultrasound guidance, and histopathologic examination revealed a diffuse non-Hodgkin lymphoma of large cells with immunophenotype B. A clinical and a pathological case as well as a review of the clinical, pathological and radiological findings of this disease are presented.

Silvana I. Romero Vidomlansky

2011-06-01

242

Quimioterapia associada à terapia anti-retroviral de alta eficácia no tratamento dos linfomas não-Hodgkin agressivos relacionados à Síndrome da Imunodeficiência Adquirida / Chemotherapy combined with highly active antiretroviral therapy for the treatment of aggressive AIDS related lymphomas  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Linfoma não-Hodgkin é uma das complicações oncológicas mais freqüentes em portadores da Síndrome da Imunodeficiência Adquirida (AIDS). Em outros países, após a introdução da terapia anti-retroviral de alta atividade (HAART), a queda na incidência dos linfomas agressivos sistêmicos ficou aquém das ex [...] pectativas, embora a sobrevida destes pacientes tenha triplicado. No Brasil, pouco se conhece a respeito do comportamento clínico e da sobrevida dos pacientes com linfoma e AIDS na era pós-HAART. O objetivo deste estudo foi avaliar retrospectivamente 25 pacientes com linfoma e AIDS, tratados com a associação de quimioterapia e HAART. Em concordância com a literatura, a maior parte dos pacientes era do sexo masculino - 20 (80%), com mediana de idade de 39 anos. Houve predomínio do subtipo histológico Difuso de Grandes Células B - 13 (52%), de pacientes em estádios avançados - 15 (60%), com envolvimento extranodal - 22 (88%) e com sintomas B - 18 (72%). O diagnóstico prévio de AIDS observado em 14 (56%) foi superior em nossa casuística em relação ao descrito por outros autores. Cinqüenta e dois por cento dos pacientes obtiveram RC, com SLD e SG em três anos de 54% e 42%, respectivamente e mediana de SG de 15 meses. Toxicidade hematológica e infecções foram freqüentes, porém nenhum óbito foi relacionado à sua ocorrência. Concluímos que o tratamento combinado com quimioterapia e HAART é factível em pacientes brasileiros, podendo propiciar uma sobrevida global similar à descrita por alguns grupos internacionais, com um perfil aceitável de toxicidade. Abstract in english Non-Hodgkin lymphoma is one of the most frequent oncological complications in patients with the Acquired Immune-Deficiency Syndrome (AIDS). In other countries, after the introduction of the Highly Active Antiretroviral Therapy (HAART), the drop in the incidence of systemic aggressive lymphomas was b [...] elow expectations, although the survival of these patients rose. In Brazil, little is known about the clinical behavior and survival of the patients with lymphoma and AIDS in the post-HAART era. The aim of this study was to retrospectively evaluate 25 patients with lymphomas and AIDS, treated with the combination of chemotherapy and HAART. In agreement with the literature most of the patients were male (20 patients - 80%) with a median age of 39 years. We observed a predominance of the Diffuse Large B Cell Lymphoma subtype (13 patients - 52%), advanced stage (15 patients - 60%), with extra-nodal disease (22 patients - 88%) and B symptoms (18 patients - 72%). Previous AIDS diagnosis was present in 14 patients (56%), higher than that reported in other series. Fifty-two percent achieved CR, the estimated probability of overall survival and disease-free survival at 3 years were 54% e 42%, respectively. The median overall survival time was 15 months. Hematological toxicity and infections were frequently observed, but no toxicity-related deaths were seen. Therefore we conclude that the combined chemotherapy-HAART treatment is feasible in Brazilian patients and can provide similar overall survival than that described for some international groups, with an acceptable toxicity profile.

Juliana, Pereira; Abrahão E, Hallack Neto; Luís F., Pracchia; Andréa, Alcântara; Beatriz B., Maurino; Pedro E., Dorliac-Llacer; Dalton A. F., Chamone.

243

Quimioterapia associada à terapia anti-retroviral de alta eficácia no tratamento dos linfomas não-Hodgkin agressivos relacionados à Síndrome da Imunodeficiência Adquirida Chemotherapy combined with highly active antiretroviral therapy for the treatment of aggressive AIDS related lymphomas  

Directory of Open Access Journals (Sweden)

Full Text Available Linfoma não-Hodgkin é uma das complicações oncológicas mais freqüentes em portadores da Síndrome da Imunodeficiência Adquirida (AIDS. Em outros países, após a introdução da terapia anti-retroviral de alta atividade (HAART, a queda na incidência dos linfomas agressivos sistêmicos ficou aquém das expectativas, embora a sobrevida destes pacientes tenha triplicado. No Brasil, pouco se conhece a respeito do comportamento clínico e da sobrevida dos pacientes com linfoma e AIDS na era pós-HAART. O objetivo deste estudo foi avaliar retrospectivamente 25 pacientes com linfoma e AIDS, tratados com a associação de quimioterapia e HAART. Em concordância com a literatura, a maior parte dos pacientes era do sexo masculino - 20 (80%, com mediana de idade de 39 anos. Houve predomínio do subtipo histológico Difuso de Grandes Células B - 13 (52%, de pacientes em estádios avançados - 15 (60%, com envolvimento extranodal - 22 (88% e com sintomas B - 18 (72%. O diagnóstico prévio de AIDS observado em 14 (56% foi superior em nossa casuística em relação ao descrito por outros autores. Cinqüenta e dois por cento dos pacientes obtiveram RC, com SLD e SG em três anos de 54% e 42%, respectivamente e mediana de SG de 15 meses. Toxicidade hematológica e infecções foram freqüentes, porém nenhum óbito foi relacionado à sua ocorrência. Concluímos que o tratamento combinado com quimioterapia e HAART é factível em pacientes brasileiros, podendo propiciar uma sobrevida global similar à descrita por alguns grupos internacionais, com um perfil aceitável de toxicidade.Non-Hodgkin lymphoma is one of the most frequent oncological complications in patients with the Acquired Immune-Deficiency Syndrome (AIDS. In other countries, after the introduction of the Highly Active Antiretroviral Therapy (HAART, the drop in the incidence of systemic aggressive lymphomas was below expectations, although the survival of these patients rose. In Brazil, little is known about the clinical behavior and survival of the patients with lymphoma and AIDS in the post-HAART era. The aim of this study was to retrospectively evaluate 25 patients with lymphomas and AIDS, treated with the combination of chemotherapy and HAART. In agreement with the literature most of the patients were male (20 patients - 80% with a median age of 39 years. We observed a predominance of the Diffuse Large B Cell Lymphoma subtype (13 patients - 52%, advanced stage (15 patients - 60%, with extra-nodal disease (22 patients - 88% and B symptoms (18 patients - 72%. Previous AIDS diagnosis was present in 14 patients (56%, higher than that reported in other series. Fifty-two percent achieved CR, the estimated probability of overall survival and disease-free survival at 3 years were 54% e 42%, respectively. The median overall survival time was 15 months. Hematological toxicity and infections were frequently observed, but no toxicity-related deaths were seen. Therefore we conclude that the combined chemotherapy-HAART treatment is feasible in Brazilian patients and can provide similar overall survival than that described for some international groups, with an acceptable toxicity profile.

Juliana Pereira

2004-01-01

244

Linfoma testicular primario con afectación extranodal / Primary testicular lymphoma with extranodal involvement  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish Objetivos: Presentamos un caso de masa testicular derecha en varón de 65 años con afectación sincrónica de piel y anillo de Waldeyer, datos que nos orientan a que se trate de un linfoma testicular maligno por lo característico de la presentación del cuadro clínico. Material/Resultados: Se realiza un [...] a presentación y comentarios de las características del caso clínico, así como una revisión de la literatura. Conclusiones: El linfoma testicular primario es un tumor testicular infrecuente, suponiendo no más del 9% de los tumores testiculares en las series con mayor incidencia; a su vez el linfoma testicular como tumor hematopoyético es infrecuente, con una incidencia del 1% de los linfomas, pero debido a su histopatología en la mayoría de los casos de alta malignidad, les hace ser de los tumores testiculares más agresivos. La edad de aparición es por encima de los 60 años, convirtiéndose en el tumor más frecuente para este grupo de edad. En el momento del diagnóstico el 70% de los pacientes presentan estadios I y II de Ann Arbor. Cuando el debut es en forma de estadio avanzado, las localizaciones extranodales más frecuentes son el sistema nervioso central, la piel, el anillo de Waldeyer y el pulmón. Abstract in english We report the case of a 65-year-old man who presented with a right testicular mass and synchronous involvement of skin and Waldeyer's ring. These facts led us to the working diagnosis of malignant primary testicular lymphoma. Material/Results: We present the case with comments and make a bibliograph [...] ic review of the disease. Conclusions: Primary testicular lymphoma is an uncommon testicular tumour that accounts for not more that 9% of all testicular tumours in the series with higher incidence. Testicular lymphomas are also rare among haematopoietic tumours, accounting for just 1% of all lymphomas, but due to their highly malignant histopathology they may become highly aggressive tumours. Patient age at presentation is over 60 years which makes it the most frequent tumour for this age group. 70% of recently diagnosed patients show Ann Arbor stages I and II. Tumours in advanced-stage have a predilection for spreading to extranodal sites such as central nervous system, skin, Waldeyer's ring and lungs.

Cristóbal, García Peñalver; Andrés, Lecki; Carlota, Sevilla Cecilia; Mario, Díaz Delgado; Juan Luis, Parra Escobar; Eloy, Sánchez Blasco.

2009-08-01

245

Linfoma no Hodgkin laríngeo: Reporte de un caso / Laryngeal non Hodgkin Lymphoma: Case Report  

Scientific Electronic Library Online (English)

Full Text Available SciELO Chile | Language: Spanish Abstract in spanish Los linfomas de la laringe son infrecuentes, correspondiendo a menos del 1% de las neoplasias de esta ubicación. La detección temprana puede permitir una mejor atención y eventualmente un mejor pronóstico. Se presenta un caso de linfoma no Hodgkin supraglótico derecho, correspondiente a una paciente [...] de sexo femenino de 68 años, que consulta por disfonía progresiva de varios meses de evolución que se intensifica durante el último mes. La nasofibroscopía mostró una lesión tumoral que comprometía el repliegue aritenoepiglótico derecho, con mucosa sana. La tomografía axial computarizada objetivó un tumor de hemilaringe derecha de aspecto sólido que se extendía desde la base de la epiglotis hasta la glotis. La resonancia magnética informó un proceso expansivo que comprometía la región supraglótica derecha, de aspecto benigno, sin infiltración. Se extirpó un tumor submucoso en su totalidad por tirotomía media. En el examen histopatológico se observaron elementos compatibles con linfoma no Hodgkin difuso, lo que fue confirmado por técnica de inmunohistoquímica. Se trató con esquema CHOP de quimioterapia. No ha habido recidiva tumoral al 3° año de seguimiento. Los linfomas no Hodgkin de laringe son poco frecuentes. Se describen las características y manejo de este tipo de tumores. Abstract in english Lymphomas of the larynx are rare, accounting for less than 1%% of neoplasms in this location. Early detection can allow better care, and possibly a better prognosis. We present a case of a right supraglottic Non-Hodgkin Lymphoma, corresponding to a female patient of 68 years who consulted for hoarse [...] ness of several months that progressed during the last month. Fibroscopic evaluation showed a tumor involving the right aryepiglottic fold, without mucosal lesion. Computed tomography showed a solid tumor of the right hemilarynx, that extends from base of epiglottis to glottis. Magnetic resonance showed tumor expansion process that involves the right epiglottic region, of benign appearence, without infiltration. We perform a complete removal of the submucosal tumor externally by a medial laryngeal thyroidotomy. Histopathological examination showed elements compatible with diffuse Non-Hodgkin Lymphoma, which was confirmed by immunohistochemestry. CHOP chemotherapy was indicated. Currently, patient followed up for 3 years, with no signs of tumor recurrence. Non-Hodgkin Lymphomas of the larynx are rare. We describe the characteristics and management of these tumors.

Jaime, Osorio M; Marcelo, Faraggi A; Felipe, Cardemil M.

2013-04-01

246

Linfomas primarios de testículo: Análisis clínicopatológico de 10 casos. Experiencia en el Instituto Nacional de Cancerología  

Scientific Electronic Library Online (English)

Full Text Available SciELO Mexico | Language: Spanish Abstract in spanish El linfoma no-Hodgkin (LNH) es la neoplasia testicular más común en hombres viejos y rara en hombres jóvenes. La gran mayoría de los linfomas primarios de testículo (LPT) es clasificada como linfomas de grado intermedio o alto. Objetivo: describir las características clínicas, morfológicas e inmunof [...] enotípicas de los LPT atendidos en un hospital de referencia. Material y métodos: de 1986 a 1999 se revisaron los casos de LPT. Se analizaron los datos clínicos, estudios de laboratorio, evolución, tratamiento y se realizaron cortes en blanco para estudios de inmunohistoquímica (IH). Resultados: se incluyeron 10 pacientes con diagnóstico de LPT. El promedio de edad fue de 62.3 años (margen 42-81), en nueve pacientes se realizó orquiectomía como modalidad terapéutica inicial. Otros tratamientos posteriores al diagnóstico fueron; quimioterapia (60%) y radioterapia (20%). Histológicamente, los testículos mostraron infiltración difusa por células grandes de estirpe linfoide. Basados en la clasificación de la REAL, todos los casos fueron clasificados como linfomas difusos de células grandes. En ocho casos se realizó estudio de IH; 7/8 tumores expresaron inmunofenotipo B y sólo un caso inmunofenotipo T. Abstract in english Non-Hodgkin lymphoma is the most common primary testicular neoplasm of older men but is rare in young men. The vast majority of primary testicular lymphomas (PTL) are intermediate- to high-grade lymphomas. Objective: to describe the clinical, morphologic, and immunophenotypic characteristics of PTL [...] seen in a referral center. Material and Methods: we reviewed the cases of PTL seen from 1986 to 1999. We obtained data of laboratory tests, clinical course, treatment, and immunohistochemical studies. Results: 10 patients with diagnosis of PTL were identified. Median age was 62.3 years (range 42-81 years), and nine patients underwent orchiectomy as initial therapeutic procedure. Other treatment modalities after diagnosis included combination chemotherapy (60%) and combination radiotherapy (20%). Histologically, testes showed diffuse dense infiltration of large lymphoma cells. All cases were classified as diffuse large cell lymphoma according to REAL classification. Eight cases were studied with use of paraffin-section immunoperoxidase, 7/8 tumors were B-lineage lymphomas, and one was a T-lineage lymphoma.

Alejandro, Avilés Salas; Julia, Turbiner Miasnikova; Juan R., Labardini Méndez; Pedro de J., Sobrevilla Calvo.

2004-04-01

247

Linfomas primarios de testículo: Análisis clínicopatológico de 10 casos. Experiencia en el Instituto Nacional de Cancerología  

Scientific Electronic Library Online (English)

Full Text Available SciELO Mexico | Language: Spanish Abstract in spanish El linfoma no-Hodgkin (LNH) es la neoplasia testicular más común en hombres viejos y rara en hombres jóvenes. La gran mayoría de los linfomas primarios de testículo (LPT) es clasificada como linfomas de grado intermedio o alto. Objetivo: describir las características clínicas, morfológicas e inmunof [...] enotípicas de los LPT atendidos en un hospital de referencia. Material y métodos: de 1986 a 1999 se revisaron los casos de LPT. Se analizaron los datos clínicos, estudios de laboratorio, evolución, tratamiento y se realizaron cortes en blanco para estudios de inmunohistoquímica (IH). Resultados: se incluyeron 10 pacientes con diagnóstico de LPT. El promedio de edad fue de 62.3 años (margen 42-81), en nueve pacientes se realizó orquiectomía como modalidad terapéutica inicial. Otros tratamientos posteriores al diagnóstico fueron; quimioterapia (60%) y radioterapia (20%). Histológicamente, los testículos mostraron infiltración difusa por células grandes de estirpe linfoide. Basados en la clasificación de la REAL, todos los casos fueron clasificados como linfomas difusos de células grandes. En ocho casos se realizó estudio de IH; 7/8 tumores expresaron inmunofenotipo B y sólo un caso inmunofenotipo T. Abstract in english Non-Hodgkin lymphoma is the most common primary testicular neoplasm of older men but is rare in young men. The vast majority of primary testicular lymphomas (PTL) are intermediate- to high-grade lymphomas. Objective: to describe the clinical, morphologic, and immunophenotypic characteristics of PTL [...] seen in a referral center. Material and Methods: we reviewed the cases of PTL seen from 1986 to 1999. We obtained data of laboratory tests, clinical course, treatment, and immunohistochemical studies. Results: 10 patients with diagnosis of PTL were identified. Median age was 62.3 years (range 42-81 years), and nine patients underwent orchiectomy as initial therapeutic procedure. Other treatment modalities after diagnosis included combination chemotherapy (60%) and combination radiotherapy (20%). Histologically, testes showed diffuse dense infiltration of large lymphoma cells. All cases were classified as diffuse large cell lymphoma according to REAL classification. Eight cases were studied with use of paraffin-section immunoperoxidase, 7/8 tumors were B-lineage lymphomas, and one was a T-lineage lymphoma.

Alejandro, Avilés Salas; Julia, Turbiner Miasnikova; Juan R., Labardini Méndez; Pedro de J., Sobrevilla Calvo.

248

Linfoma no Hodgkin laríngeo: Reporte de un caso / Laryngeal non Hodgkin Lymphoma: Case Report  

Scientific Electronic Library Online (English)

Full Text Available SciELO Chile | Language: Spanish Abstract in spanish Los linfomas de la laringe son infrecuentes, correspondiendo a menos del 1% de las neoplasias de esta ubicación. La detección temprana puede permitir una mejor atención y eventualmente un mejor pronóstico. Se presenta un caso de linfoma no Hodgkin supraglótico derecho, correspondiente a una paciente [...] de sexo femenino de 68 años, que consulta por disfonía progresiva de varios meses de evolución que se intensifica durante el último mes. La nasofibroscopía mostró una lesión tumoral que comprometía el repliegue aritenoepiglótico derecho, con mucosa sana. La tomografía axial computarizada objetivó un tumor de hemilaringe derecha de aspecto sólido que se extendía desde la base de la epiglotis hasta la glotis. La resonancia magnética informó un proceso expansivo que comprometía la región supraglótica derecha, de aspecto benigno, sin infiltración. Se extirpó un tumor submucoso en su totalidad por tirotomía media. En el examen histopatológico se observaron elementos compatibles con linfoma no Hodgkin difuso, lo que fue confirmado por técnica de inmunohistoquímica. Se trató con esquema CHOP de quimioterapia. No ha habido recidiva tumoral al 3° año de seguimiento. Los linfomas no Hodgkin de laringe son poco frecuentes. Se describen las características y manejo de este tipo de tumores. Abstract in english Lymphomas of the larynx are rare, accounting for less than 1%% of neoplasms in this location. Early detection can allow better care, and possibly a better prognosis. We present a case of a right supraglottic Non-Hodgkin Lymphoma, corresponding to a female patient of 68 years who consulted for hoarse [...] ness of several months that progressed during the last month. Fibroscopic evaluation showed a tumor involving the right aryepiglottic fold, without mucosal lesion. Computed tomography showed a solid tumor of the right hemilarynx, that extends from base of epiglottis to glottis. Magnetic resonance showed tumor expansion process that involves the right epiglottic region, of benign appearence, without infiltration. We perform a complete removal of the submucosal tumor externally by a medial laryngeal thyroidotomy. Histopathological examination showed elements compatible with diffuse Non-Hodgkin Lymphoma, which was confirmed by immunohistochemestry. CHOP chemotherapy was indicated. Currently, patient followed up for 3 years, with no signs of tumor recurrence. Non-Hodgkin Lymphomas of the larynx are rare. We describe the characteristics and management of these tumors.

Jaime, Osorio M; Marcelo, Faraggi A; Felipe, Cardemil M.

249

O tratado de Lisboa e o Sermão de Santo António aos Peixes  

Digital Repository Infrastructure Vision for European Research (DRIVER)

O artigo passa em revista o fracasso do Tratado Constitucional, indagando sobre os elementos de continuidade e ruptura entre este tratado e o Tratado de Lisboa. Como pouco mudou de um tratado para o outro, e como os líderes europeus subtrairam o Tratado de Lisboa à ratificação através de referendos nacionais, somos levados a uma improvável semelhança com o Sermão de Santo António aos Peixes: a integração europeia continua a avançar divorciada dos cidadãos. The p...

Vila Maior, Paulo

2008-01-01

250

Segmentation method of intravascular ultrasound images of human coronary arteries.  

Science.gov (United States)

The goal of this study was to show the feasibility of a 2D segmentation fast-marching method (FMM) in the context of intravascular ultrasound (IVUS) imaging of coronary arteries. The original FMM speed function combines gradient-based contour information and region information, that is the gray level probability density functions of the vessel structures, that takes into account the variability in appearance of the tissues and the lumen in IVUS images acquired at 40 MHz. Experimental results on 38 in vivo IVUS sequences yielded mean point-to-point distances between detected vessel wall boundaries and manual validation contours below 0.11 mm, and Hausdorff distances below 0.33 mm, as evaluated on 3207 images. The proposed method proved to be robust in taking into account various artifacts in ultrasound images: partial shadowing due to calcium inclusions within the plaque, side branches adjacent to the main artery to segment, the presence of a stent, injection of contrast agent or dissection, as tested on 209 images presenting such artifacts. PMID:24119335

Destrempes, François; Roy Cardinal, Marie-Hélène; Allard, Louise; Tardif, Jean-Claude; Cloutier, Guy

2014-03-01

251

Disseminated intravascular coagulation complicating HELLP syndrome: perioperative management.  

Science.gov (United States)

HELLP syndrome may lead to disseminated intravascular coagulation (DIC) which can make emergency surgery a serious challenge. A 29-year-old female presented with haematuria, epistaxis and hypertension in the emergency ward and a diagnosis of DIC complicating HELLP in preeclampsia was made. She had continuous epistaxis and elective tracheal intubation was carried out. During emergency caesarean section the patient was managed with blood products, antihypertensive drugs and general anaesthesia together with invasive monitoring. She required postoperative ventilatory support. HELLP syndrome may progress to DIC in 15-38% of patients. The prothrombin time, activated partial thromboplastin time and serum fibrinogen levels are normal in HELLP syndrome but are prolonged in DIC. Evaluation of more sensitive markers of DIC, such as antithrombin III, ?-2 antiplasmin, plasminogens, fibrin monomer and D-dimers, differentiates DIC from HELLP syndrome. Aggressive treatment is indicated and delivery should be expedited, by caesarean section if necessary although vaginal delivery is not contraindicated, along with control of blood pressure and coagulation abnormality. We conclude that patients with DIC complicating HELLP syndrome and preeclampsia require great vigilance and multimodal management in the perioperative period for uneventful outcome. PMID:21686497

Garg, Rakesh; Nath, M P; Bhalla, A P; Kumar, Ashwani

2009-01-01

252

Intravascular embolization of radiculomedullary and intramedullary spinal arteriovenous malformations  

International Nuclear Information System (INIS)

Treatment of spinal arteriovenous malformations (AVMs) by intravascular embolization techniques is being performed with increasing frequency. Thus far, the authors treated 21 patients with spinal AVMs of the radiculomedullary and intramedullary type. Clinically, patients presented with repetitive subarachnoid hemorrhages, progressive neurologic dysfunction, or acute deterioration due to large hemorrhage or acute thrombosis of venous outflow. Patients ranged in age from 18 to 76 years, and in all but two cases, embolization was successful in completely obliterating the nidus of the malformation. Superselective catheterization of the feeding pedicles was performed using real-time digital subtraction angiography, and embolization performed with a variety of embolic materials including isobutyl cyanoacrylate, barium-impregnated spheres and polyvinyl alcohol particles. In 16 of 19 patients (84%) there has been improvement of neurologic symptoms following embolization therapy. The other three demonstrated no further progression, but little return of function due to long-standing cord atrophy. Complications from treatment included two patients with transient deteriorating neurologic dysfunction following embolization and one patient with quadripresis following treatment of a high cervical cord AVM. The indications, treatment techniques, and therapeutic results from embolization therapy for spinal AVMs are presented

253

Optimization of intravascular brachytherapy treatment planning in peripheral arteries.  

Science.gov (United States)

This work deals with the treatment planning optimization for intravascular brachytherapy (IVB) in peripheral arteries. The objective is both to quantitatively study the validity of different hypotheses required for a reliable application of the treatment with current techniques, and to contribute to the definition and the specification of a new optimized procedure taking into account the actual patient's vessel geometry. The detection of vascular luminal surface was performed by an image analysis process, i.e., virtual active navigation, applied to standard CT data. Dose distribution was calculated according to the formalism proposed and recommended by the AAPM in TG43 and TG60. A method combining simulated annealing and BFGS algorithms was applied to optimize the parameters associated with the dwell points such as their number, positions, and dwell times. Dose-surface histogram (DSH) was used to evaluate the dose distribution results. Four levels of accuracy in target surface description were tested. The application of this optimization method to four different CT data sets including patient data, phantom and animal models showed that the treatment plan can be improved when the actual vessel geometry has been taken into account. PMID:17574815

Zhou, Zhengdong; Haigron, Pascal; Shu, Huazhong; Yu, Wenxue; Moisan, Cécile; Manens, Jean-Pierre; Lucas, Antoine; Luo, Limin

2007-09-01

254

Mapping of arterial transit time by intravascular signal selection.  

Science.gov (United States)

The arterial transit time (?a ) is a potentially important physiological parameter which may provide valuable information for the characterization of cerebrovascular diseases. The present study shows that ?a can be measured by arterial spin labeling (ASL) applied quasi-continuously in an amplitude-modulated fashion at the human neck. Imaging was performed using short repetition times and excitation flip angles of 90°, which resulted in the selection of an ASL signal of mostly intravascular origin. Model-independent estimates of ?a were obtained directly from the temporal shift of the ASL time series. An extended two-compartment perfusion model was developed in order to simulate the basic features of the proposed method and to validate the evaluation procedure. Vascular structures found in human ?a maps, such as the circle of Willis or cerebral border zones, hint at the sensitivity of the method to most sizes of arterial vessels. Group-averaged values of ?a measured from the carotid bifurcation to the tissue of interest in selected regions of the human brain ranged from 925?ms in the insular cortex to 2000?ms in the thalamic region. PMID:24610794

Mildner, Toralf; Müller, Karsten; Hetzer, Stefan; Trampel, Robert; Driesel, Wolfgang; Möller, Harald E

2014-05-01

255

Effects of intravascular contrast media on blood-brain barrier  

International Nuclear Information System (INIS)

The effects upon the rabbit blood-brain barrier after intracarotid injection of two non-ionic contrast media, iopentol (a monomer) and iodixanol (a dimer) were compared. Iothalamate and iohexol were used as reference substances. 99Tcm-DTPA, 125I-HSA and Trypsin blue were used as tracers in order to demonstrate various degrees of damage to the barrier. Injection of iothalamate led to large extravasation of 99Tcm-DTPA, 125I-HSA and Trypan blue which means severe damage of the blood-brain barrier. Injection of iopentol and iohexol resulted in some extravasation of all three tracers used, whereas injection of iodixanol only led to extravasation of the small molecule tracer 99Tcm-DTPA demonstrating minor changes of the barrier. At computed tomography of the brain with intravascular contrast medium enhancement it is safer to use iodixanol than iothalamate. Iodixanol is expected to cause even less adverse effects to the brain after intraarterial injection than iopentol and iohexol. (orig.)

256

Intravascular ultrasound based dose assessment in endovascular brachytherapy  

International Nuclear Information System (INIS)

Background: the role of endovascular brachytherapy in restenosis prevention is well documented. Dose is usually prescribed at a fixed distance from the source axis by angiographic quantification of vessel diameter. Recently, intravascular ultrasound (IVUS) was introduced in dose prescription, allowing a better evaluation of the vessel anatomy. This study retrospectively explores the difference between prescription following angiographic vessel sizing and delivered dose calculated with IVUS. Methods and results: Seventeen lesions were studied with IVUS, identifying on irradiated segment, three sections on which measuring minimal and maximal distance from the centre of IVUS catheter to the adventitia; using dedicated software, corresponding doses were calculated. The dose ranged widely, with maximal and minimal values of 71.6 and 4.9 Gy; furthermore, heterogeneity in dose among different sections was observed. In the central section, the maximal dose was 206% of the one prescribed with the QCA model at 2 mm from the source axis, while the minimal dose was 96%. In proximal and distal sections, respective values were 182, 45, 243, and 122%. Conclusions: Our analysis confirmed the dose inhomogeneity delivered with an angiographic fixed-dose prescription strategy. A dose variation was found along the irradiated segment due to the differences in vessel thickness. IVUS emerged as an important tool in endovascular brachytherapy, especially for irregular-shaped vesselsally for irregular-shaped vessels

257

Consensus standards for acquisition, measurement, and reporting of intravascular optical coherence tomography studies : a report from the international working group for intravascular optical coherence tomography standardization and validation  

DEFF Research Database (Denmark)

The purpose of this document is to make the output of the International Working Group for Intravascular Optical Coherence Tomography (IWG-IVOCT) Standardization and Validation available to medical and scientific communities, through a peer-reviewed publication, in the interest of improving the diagnosis and treatment of patients with atherosclerosis, including coronary artery disease.

Tearney, Guillermo J; Regar, Evelyn

2012-01-01

258

Primary MALT lymphomas of the stomach: A pathological study of 18 cases / Linfomas gástricos primarios tipo MALT: un estudio patológico de 18 casos  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: English Abstract in spanish Objetivo: es difícil que alguien que padezca un linfoma gástrico de tipo MALT pueda librarse de la enfermedad,... a menos que se le trate con medicación para Helicobacter pylori. Material y métodos: se analizó una cohorte de 18 pacientes. Diez huéspedes tenían linfoma gástrico de tipo MALT y se trat [...] aron con resección gástrica como tratamiento inicial. Ocho recibieron antibióticos frente a Helicobacter pylori como tratamiento inicial. En los 18 pacientes se evaluaron la presencia de Helicobacter pylori, los hallazgos endoscópicos y los rasgos patológicos. Se realizó una inmunohistoquímica para valorar el bcl-2 y el p53. Resultados: los pacientes con linfoma MALT de grado bajo: a) dieron positivo a Helicobacter pylori (5 de 5); b) tenían una lesión superficial (5 de 5); c) no tenían afectados los ganglios linfáticos (5 de 5); y d) se estadificaron a la baja por comparación con los pacientes con tumores de grado alto. El bcl-2 fue positivo en 4 de los 5 tumores de grado bajo y el p53 fue positivo en 12 de 13 de los de grado alto. El estudio de los pacientes durante un seguimiento de 5 años (n = 18) reveló que todos los tumores menos uno de grado bajo siguieron siendo superficiales sin progresión. Estos tumores eran bcl-2+/p53-, mientras que el único con inmunofenotipo bcl-2+/p53+ progresó hasta convertirse en un tumor de bajo grado ulcerado tras la desaparición de Helicobacter pylori. Se observó una regresión completa en 6 de los 8 pacientes del grupo no tratado con cirugía (n = 8) tras la erradicación de Helicobacter pylori. Estos tumores eran superficiales, de bajo grado, con ganglios negativos y bcl-2+/p53 no concluyente (n = 2); superficiales, de bajo grado, con ganglios negativos y bcl-2+/p53- (n = 2), y ulcerativos, de grado alto, con ganglios negativos y bcl-2+/p53- (n = 2). Los dos tumores persistentes eran ulcerativos, de grado alto con ganglios negativos y bcl-2+/p53+. Conclusión: el linfoma gástrico de tipo MALT, Helicobacter pylori-positivo, superficial, de grado bajo y bcl-2+/p53- desaparece tras la erradicación de Helicobacter pylori. Abstract in english Aim: it is doubtful that whoever is suffering from gastric malt lymphoma will escape from the disease, if treated with medication against helicobacter pylori. Material and methods: a cohort of 18 patients was analysed. Ten hosts had primary gastric malt lymphoma and were treated with gastric resecti [...] on as the initial therapy. Eight hosts received antibiotics against Helicobacter pylori as the initial treatment. In all 18 patients Helicobacter pylori status, endoscopic findings and pathology features were evaluated. Immunohistochemistry was performed to assess the bcl-2 and p53 status. Results: patients with low grade malt lymphoma: a) were Helicobacter pylori positive (5 of 5); b) had a superficial lesion (5 of 5); c) had no lymph node involvement (5 of 5); and d) were downstaged by comparison to patients with high grade tumor. Bcl-2 was positive in 4 of 5 low grade tumors, and p53 was positive in 12 of 13 high grade ones. Investigation of patients with 5-year follow up (n = 18) revealed that all but one low-grade tumors remained superficial with no progression. These tumors were bcl-2+/p53-, and the one with a bcl-2+/p53+ immunophenotype progressed to an ulcerated low-grade tumor after disappearance of Helicobacter pylori. Complete regression was found in 6 of 8 patients from the non surgically treated group (n = 8) after Helicobacter pylori eradication. These tumors were superficial/low grade/node negative/bcl-2+/p53 inconclusive (n = 2), superficial/low grade/node negative/bcl-2+/p53- (n = 2), and ulcerative/high grade/node negative/bcl-2+/p53- (n = 2). The two persistent tumors were ulcerative/high grade/node negative/bcl-2+/p53+. Conclusion: gastric malt lymphoma Helicobacter pylori+/superficial/low grade/bcl-2+/p53- will disappear after Helicobacter pylori eradication.

I., Venizelos; D., Tamiolakis; M., Lambropoulou; S., Bolioti; S., Nikolaidou; G., Alexiadis; N., Papadopoulos.

259

Primary MALT lymphomas of the stomach: A pathological study of 18 cases Linfomas gástricos primarios tipo MALT: un estudio patológico de 18 casos  

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Full Text Available Aim: it is doubtful that whoever is suffering from gastric malt lymphoma will escape from the disease, if treated with medication against helicobacter pylori. Material and methods: a cohort of 18 patients was analysed. Ten hosts had primary gastric malt lymphoma and were treated with gastric resection as the initial therapy. Eight hosts received antibiotics against Helicobacter pylori as the initial treatment. In all 18 patients Helicobacter pylori status, endoscopic findings and pathology features were evaluated. Immunohistochemistry was performed to assess the bcl-2 and p53 status. Results: patients with low grade malt lymphoma: a were Helicobacter pylori positive (5 of 5; b had a superficial lesion (5 of 5; c had no lymph node involvement (5 of 5; and d were downstaged by comparison to patients with high grade tumor. Bcl-2 was positive in 4 of 5 low grade tumors, and p53 was positive in 12 of 13 high grade ones. Investigation of patients with 5-year follow up (n = 18 revealed that all but one low-grade tumors remained superficial with no progression. These tumors were bcl-2+/p53-, and the one with a bcl-2+/p53+ immunophenotype progressed to an ulcerated low-grade tumor after disappearance of Helicobacter pylori. Complete regression was found in 6 of 8 patients from the non surgically treated group (n = 8 after Helicobacter pylori eradication. These tumors were superficial/low grade/node negative/bcl-2+/p53 inconclusive (n = 2, superficial/low grade/node negative/bcl-2+/p53- (n = 2, and ulcerative/high grade/node negative/bcl-2+/p53- (n = 2. The two persistent tumors were ulcerative/high grade/node negative/bcl-2+/p53+. Conclusion: gastric malt lymphoma Helicobacter pylori+/superficial/low grade/bcl-2+/p53- will disappear after Helicobacter pylori eradication.Objetivo: es difícil que alguien que padezca un linfoma gástrico de tipo MALT pueda librarse de la enfermedad,... a menos que se le trate con medicación para Helicobacter pylori. Material y métodos: se analizó una cohorte de 18 pacientes. Diez huéspedes tenían linfoma gástrico de tipo MALT y se trataron con resección gástrica como tratamiento inicial. Ocho recibieron antibióticos frente a Helicobacter pylori como tratamiento inicial. En los 18 pacientes se evaluaron la presencia de Helicobacter pylori, los hallazgos endoscópicos y los rasgos patológicos. Se realizó una inmunohistoquímica para valorar el bcl-2 y el p53. Resultados: los pacientes con linfoma MALT de grado bajo: a dieron positivo a Helicobacter pylori (5 de 5; b tenían una lesión superficial (5 de 5; c no tenían afectados los ganglios linfáticos (5 de 5; y d se estadificaron a la baja por comparación con los pacientes con tumores de grado alto. El bcl-2 fue positivo en 4 de los 5 tumores de grado bajo y el p53 fue positivo en 12 de 13 de los de grado alto. El estudio de los pacientes durante un seguimiento de 5 años (n = 18 reveló que todos los tumores menos uno de grado bajo siguieron siendo superficiales sin progresión. Estos tumores eran bcl-2+/p53-, mientras que el único con inmunofenotipo bcl-2+/p53+ progresó hasta convertirse en un tumor de bajo grado ulcerado tras la desaparición de Helicobacter pylori. Se observó una regresión completa en 6 de los 8 pacientes del grupo no tratado con cirugía (n = 8 tras la erradicación de Helicobacter pylori. Estos tumores eran superficiales, de bajo grado, con ganglios negativos y bcl-2+/p53 no concluyente (n = 2; superficiales, de bajo grado, con ganglios negativos y bcl-2+/p53- (n = 2, y ulcerativos, de grado alto, con ganglios negativos y bcl-2+/p53- (n = 2. Los dos tumores persistentes eran ulcerativos, de grado alto con ganglios negativos y bcl-2+/p53+. Conclusión: el linfoma gástrico de tipo MALT, Helicobacter pylori-positivo, superficial, de grado bajo y bcl-2+/p53- desaparece tras la erradicación de Helicobacter pylori.

I. Venizelos

2007-05-01

260

Linfoma do tecido linfóide associado ao brônquio com evolução fatal / Fatal outcome in bronchus-associated lymphoid tissue lymphoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Linfomas primários do pulmão são raros. O tipo histológico mais freqüente é o linfoma do tecido linfóide associado ao brônquio. Este tipo de linfoma tem curso indolente e excelente resposta à terapia. Um terço dos casos é descoberto incidentalmente. Devido à raridade desta doença, no entanto, pouco [...] se conhece sobre sua história natural em termos de disseminação e evolução. Neste relato, descrevemos o caso incomum de um homem de 61 anos que recusou o tratamento após diagnóstico de linfoma do tecido linfóide associado ao brônquio e, 2 anos após o diagnóstico, morreu por infiltração pulmonar maciça sem disseminação para outros órgãos. Abstract in english Primary pulmonary lymphoma is rare. The most common histological type is the bronchus-associated lymphoid tissue lymphoma. This type of lymphoma has an indolent course and excellent response to therapy. One-third of all cases are diagnosed incidentally. However, due to the rarity of this disease, li [...] ttle is known about its natural history in terms of dissemination and evolution. Herein, we report the unusual case of a 61-year-old man who refused treatment after being diagnosed with bronchus-associated lymphoid tissue lymphoma and died 2 years later from massive lung infiltration without dissemination to other organs.

Romulo Loss, Mattedi; Fabiola del Carlo, Bernardi; Carlos Eduardo, Bacchi; Sheila Aparecida Coelho, Siqueira; Thais, Mauad.

 
 
 
 
261

Linfoma do tecido linfóide associado ao brônquio com evolução fatal Fatal outcome in bronchus-associated lymphoid tissue lymphoma  

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Full Text Available Linfomas primários do pulmão são raros. O tipo histológico mais freqüente é o linfoma do tecido linfóide associado ao brônquio. Este tipo de linfoma tem curso indolente e excelente resposta à terapia. Um terço dos casos é descoberto incidentalmente. Devido à raridade desta doença, no entanto, pouco se conhece sobre sua história natural em termos de disseminação e evolução. Neste relato, descrevemos o caso incomum de um homem de 61 anos que recusou o tratamento após diagnóstico de linfoma do tecido linfóide associado ao brônquio e, 2 anos após o diagnóstico, morreu por infiltração pulmonar maciça sem disseminação para outros órgãos.Primary pulmonary lymphoma is rare. The most common histological type is the bronchus-associated lymphoid tissue lymphoma. This type of lymphoma has an indolent course and excellent response to therapy. One-third of all cases are diagnosed incidentally. However, due to the rarity of this disease, little is known about its natural history in terms of dissemination and evolution. Herein, we report the unusual case of a 61-year-old man who refused treatment after being diagnosed with bronchus-associated lymphoid tissue lymphoma and died 2 years later from massive lung infiltration without dissemination to other organs.

Romulo Loss Mattedi

2007-08-01

262

Bronquiolite obliterante com pneumonia em organização e aspergiloma em paciente com linfoma-leucemia de células T  

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Full Text Available Há poucos relatos na literatura médica referentes à associação de bronquiolite obliterante com pneumonia em organização (BOPO e aspergiloma. Apresenta-se uma associação de BOPO e aspergiloma pulmonar em uma paciente com linfoma-leucemia de células T do adulto. Sugere-se que os achados deste caso representam uma associação fortuita e não a expressão de unidade nosológica.

JHAYYA TERESA S.

2000-01-01

263

Burkitt's lymphoma of the duodenum in a patient with AIDS Linfoma de Burkitt do duodeno em um paciente com AIDS  

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Full Text Available Non-Hodgkin's lymphoma of B-cell type is the second most common neoplasm after Kaposi's sarcoma, among patients with human immunodeficiency virus infection. Most non-Hodgkin's lymphoma cases that are associated with acquired immunodeficiency syndrome involve extranodal sites, especially the digestive tract and the central nervous system. We report a case of primary lymphoma of the duodenum in a patient with AIDS. Upper gastrointestinal endoscopy revealed pseudopolypoid masses found in the second portion of the duodenum. A complete diagnostic study including histological, immunohistochemical and virological analyses showed high-grade B-cell Burkitt's lymphoma. The Epstein-Barr virus genome was detected in biopsies by immunohistochemical and in situ hybridization.O linfoma não-Hodgkin de células B é a segunda neoplasia mais comum em pacientes com infecção pelo vírus da imunodeficiência humana depois do sarcoma de Kaposi. A maioria dos casos de linfoma não-Hodgkin associados com a síndrome da imunodeficiência adquirida envolve locais extraganglionares, especialmente o trato digestivo e o sistema nervoso central. Nós relatamos um caso de linfoma primário do duodeno em um paciente com AIDS. Uma endoscopia digestiva alta mostrou massas pseudopolipóides encontradas na segunda porção do duodeno. Um estudo diagnóstico completo incluindo exames histológicos, imunohistoquímicos e virológicos mostrou um linfoma de células B tipo Burkitt. Detectou-se genoma do vírus Epstein-Barr em biópsias por hibridização in situ e imuno-histoquímica.

Marcelo Corti

2007-06-01

264

Burkitt's lymphoma of the duodenum in a patient with AIDS / Linfoma de Burkitt do duodeno em um paciente com AIDS  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese O linfoma não-Hodgkin de células B é a segunda neoplasia mais comum em pacientes com infecção pelo vírus da imunodeficiência humana depois do sarcoma de Kaposi. A maioria dos casos de linfoma não-Hodgkin associados com a síndrome da imunodeficiência adquirida envolve locais extraganglionares, especi [...] almente o trato digestivo e o sistema nervoso central. Nós relatamos um caso de linfoma primário do duodeno em um paciente com AIDS. Uma endoscopia digestiva alta mostrou massas pseudopolipóides encontradas na segunda porção do duodeno. Um estudo diagnóstico completo incluindo exames histológicos, imunohistoquímicos e virológicos mostrou um linfoma de células B tipo Burkitt. Detectou-se genoma do vírus Epstein-Barr em biópsias por hibridização in situ e imuno-histoquímica. Abstract in english Non-Hodgkin's lymphoma of B-cell type is the second most common neoplasm after Kaposi's sarcoma, among patients with human immunodeficiency virus infection. Most non-Hodgkin's lymphoma cases that are associated with acquired immunodeficiency syndrome involve extranodal sites, especially the digestiv [...] e tract and the central nervous system. We report a case of primary lymphoma of the duodenum in a patient with AIDS. Upper gastrointestinal endoscopy revealed pseudopolypoid masses found in the second portion of the duodenum. A complete diagnostic study including histological, immunohistochemical and virological analyses showed high-grade B-cell Burkitt's lymphoma. The Epstein-Barr virus genome was detected in biopsies by immunohistochemical and in situ hybridization.

Marcelo, Corti; María Florencia, Villafañe; Liliana, Souto; Ricardo, Schtirbu; Marina, Narbaitz; Marcela de Dios, Soler.

265

TRATADOS INTERNACIONALES DE DERECHOS HUMANOS BAJO EL ORDENAMIENTO JURÍDICO ALEMÁN  

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Full Text Available En el presente artículo el autor analiza la posición de los tratados internacionales en general, como asimismo, los tratados de derechos humanos y de integración en el sistema jurídico alemán, considerando la posición de la doctrina y la jurisprudencia emanada de la Corte Constitucional Alemana.The article analyzes the status in the German legal system of international treaties in general, and treaties on human rights and integration in particular, from the point of view of legal scholarship and the decisions of the German Constitutional Court.

Roland Bank

2003-01-01

266

The Role of Rituximab in Lymphomas O papel do Rituximab nos linfomas  

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Full Text Available Over the last years the treatment of non-Hodgkin's lymphoma underwent a great advance in relation to the diagnosis, classification, high-dose chemotherapy, and hematopoietic stem cell transplantation. Simultaneously with this, there was the development of new drugs and support therapy which enabled an improvement in the evolution and survival of the patients. The use of monoclonal antibodies against cancer cells is an old idea and in this report the results of the role of the anti-CD20-Rituximab in lymphomas is discussed.Nos últimos anos o tratamento do linfomas não Hodgkin apresentou um grande avanço no diagnóstico, classificação, quimioterapia com altas doses e o transplante de células percursoras hematopoiéticas. Simultaneamente houve o desenvolvimento de novas drogas e no tratamento de suporte o que possibilita um avanço na evolução e sobrevida dos pacientes. A idéia do emprego de anticorpos monoclonais no tratamento do câncer é antiga e neste relato são apresentados os resultados e o papel do anti-CD20-Rituximab nos linfomas.

Bertrand Coiffier

2002-01-01

267

Linfoma não Hodgkin primário do fígado em doente com hepatite crónica a VHC  

Scientific Electronic Library Online (English)

Full Text Available SciELO Portugal | Language: Portuguese Abstract in portuguese Os autores apresentam o caso de um homem de 43 anos, com dor abdominal e sintomas constitucionais com 3 semanas de evolução, a quem se diagnosticou tumor solido do fígado e infecção crónica a Virus da Hepatite C (VHC). O tumor era um Linfoma não Hodgkin ( LNH) tipo B, primário. O doente foi submetid [...] o a quimioterapia e a tratamento para a hepatite crónica C, com boa resposta. Os autores discutem o caso e apresentam uma revisão da litera-tura sobre a associação VHC e LNH, em particular o LNH primário do fígado, e o eventual papel do virus na génese de linfomas. Abstract in english The authors present the case of a 43 year old man, with abdominal pain and constitutional symptoms during 3 weeks, in whom was diagnosed a solid liver tumor and chronic hepatitis C. The tumor was a primary cell B non-Hodgkin Lymphoma (LNH). The patient was submitted to chemotherapy and treatment for [...] hepatitis C with a favourable response. The authors discuss the case and present a review on the VHC and LNH association, the primary hepatic lymphoma in particular, and the possible role of the virus in lymphomagenesis.

M. L., Gonçalves; I., Rosa; I., Medeiros; C., Viveiros; A., Talhinhas; J. Fernândez, Mera; F., Pina; A., Queiroz.

268

The Role of Rituximab in Lymphomas / O papel do Rituximab nos linfomas  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese Nos últimos anos o tratamento do linfomas não Hodgkin apresentou um grande avanço no diagnóstico, classificação, quimioterapia com altas doses e o transplante de células percursoras hematopoiéticas. Simultaneamente houve o desenvolvimento de novas drogas e no tratamento de suporte o que possibilita [...] um avanço na evolução e sobrevida dos pacientes. A idéia do emprego de anticorpos monoclonais no tratamento do câncer é antiga e neste relato são apresentados os resultados e o papel do anti-CD20-Rituximab nos linfomas. Abstract in english Over the last years the treatment of non-Hodgkin's lymphoma underwent a great advance in relation to the diagnosis, classification, high-dose chemotherapy, and hematopoietic stem cell transplantation. Simultaneously with this, there was the development of new drugs and support therapy which enabled [...] an improvement in the evolution and survival of the patients. The use of monoclonal antibodies against cancer cells is an old idea and in this report the results of the role of the anti-CD20-Rituximab in lymphomas is discussed.

Bertrand, Coiffier.

269

Síndrome de enmascaramiento en un paciente con un linfoma primario del sistema nervioso central  

Scientific Electronic Library Online (English)

Full Text Available SciELO Argentina | Language: Spanish Abstract in spanish Se describe el caso de un varón de 37 años con un linfoma primario del sistema nervioso central y con múltiples localizaciones supra e infratentoriales. El paciente presentaba manifestaciones de inflamación intraocular como expresión de su neoplasia intracraneana (síndrome de enmascaramiento) y linf [...] ocitopenia con un recuento disminuido de CD4- como representación de una inmunodeficiencia cuya etiología no logramos identificar. El diagnóstico de linfoma se confirmó a través del estudio citológico del humor vítreo. El paciente falleció 10 meses después del comienzo de los síntomas. Abstract in english We report the case of a 37-year-old, white male with a primary central nervous system lymphoma with multiple supra and infratentorial locations. The patient developed manifestations of intraocular inflammation secondary to the intracranial neoplasm (masquerade syndrome) and lymphocytopenia -with a l [...] ow CD4 cell count- representing an immunodeficiency state which etiology was undiagnosed. The diagnosis of lymphoma was established by vitreous cytology. The patient died 10 months after the beginning of the symptoms.

J. A., Mazzei; A. L., Campos; M. J., Melero; A., Schlaen; C., Argento; J. O., Zarate.

270

Síndrome de enmascaramiento en un paciente con un linfoma primario del sistema nervioso central  

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Full Text Available Se describe el caso de un varón de 37 años con un linfoma primario del sistema nervioso central y con múltiples localizaciones supra e infratentoriales. El paciente presentaba manifestaciones de inflamación intraocular como expresión de su neoplasia intracraneana (síndrome de enmascaramiento y linfocitopenia con un recuento disminuido de CD4- como representación de una inmunodeficiencia cuya etiología no logramos identificar. El diagnóstico de linfoma se confirmó a través del estudio citológico del humor vítreo. El paciente falleció 10 meses después del comienzo de los síntomas.We report the case of a 37-year-old, white male with a primary central nervous system lymphoma with multiple supra and infratentorial locations. The patient developed manifestations of intraocular inflammation secondary to the intracranial neoplasm (masquerade syndrome and lymphocytopenia -with a low CD4 cell count- representing an immunodeficiency state which etiology was undiagnosed. The diagnosis of lymphoma was established by vitreous cytology. The patient died 10 months after the beginning of the symptoms.

J. A. Mazzei

2003-12-01

271

Linfoma primario del sistema nervioso central en una paciente con lupus eritematoso sistémico  

Scientific Electronic Library Online (English)

Full Text Available SciELO Argentina | Language: Spanish Abstract in spanish Se presenta una paciente de 36 años con diagnóstico de lupus eritematoso sistémico tratada con prednisona y ciclofosfamida que se internó por cefalea, hemiparesia y hemianestesia braquiocrural derecha de dos semanas de evolución. Se realizó una tomografía computada y una resonancia magnética nuclear [...] de cerebro que mostraron una lesión nodular frontal izquierda. Se efectuó una biopsia a cielo abierto de la lesión cerebral cuyo diagnóstico histopatológico fue linfoma B de celulas grandes, difuso. Se inició radioterapia, no completó el tratamiento por complicaciones y falleció. Son muy pocos los casos publicados de linfoma primario del sistema nervioso central asociado a lupus eritematoso sistémico. Abstract in english A 36 year-old woman with systemic lupus erythematosus was admitted to our hospital with headache, brachiocrural hemiparesis and hemianesthesia. She had been treated with prednisone and cyclophosphamide. CT scan and MRI revealed a 15 mm nodular mass enhanced with gadolinium in left frontal convexity. [...] CNS biopsy was performed and a diffuse large B-cell lymphoma was diagnosed. She was treated with radiation therapy without response and died. There are few reports of erythematosus systemic lupus associated with primary central nervous system lymphoma.

C. N., Pisoni; A. R., Grinberg; J. L., Plana; R. D., Freue; J. A., Manni; L., Paz.

272

Linfoma primario del sistema nervioso central en una paciente con lupus eritematoso sistémico  

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Full Text Available Se presenta una paciente de 36 años con diagnóstico de lupus eritematoso sistémico tratada con prednisona y ciclofosfamida que se internó por cefalea, hemiparesia y hemianestesia braquiocrural derecha de dos semanas de evolución. Se realizó una tomografía computada y una resonancia magnética nuclear de cerebro que mostraron una lesión nodular frontal izquierda. Se efectuó una biopsia a cielo abierto de la lesión cerebral cuyo diagnóstico histopatológico fue linfoma B de celulas grandes, difuso. Se inició radioterapia, no completó el tratamiento por complicaciones y falleció. Son muy pocos los casos publicados de linfoma primario del sistema nervioso central asociado a lupus eritematoso sistémico.A 36 year-old woman with systemic lupus erythematosus was admitted to our hospital with headache, brachiocrural hemiparesis and hemianesthesia. She had been treated with prednisone and cyclophosphamide. CT scan and MRI revealed a 15 mm nodular mass enhanced with gadolinium in left frontal convexity. CNS biopsy was performed and a diffuse large B-cell lymphoma was diagnosed. She was treated with radiation therapy without response and died. There are few reports of erythematosus systemic lupus associated with primary central nervous system lymphoma.

C. N. Pisoni

2003-06-01

273

Linfoma primario del sistema nervioso central en una paciente con lupus eritematoso sistémico  

Scientific Electronic Library Online (English)

Full Text Available SciELO Argentina | Language: Spanish Abstract in spanish Se presenta una paciente de 36 años con diagnóstico de lupus eritematoso sistémico tratada con prednisona y ciclofosfamida que se internó por cefalea, hemiparesia y hemianestesia braquiocrural derecha de dos semanas de evolución. Se realizó una tomografía computada y una resonancia magnética nuclear [...] de cerebro que mostraron una lesión nodular frontal izquierda. Se efectuó una biopsia a cielo abierto de la lesión cerebral cuyo diagnóstico histopatológico fue linfoma B de celulas grandes, difuso. Se inició radioterapia, no completó el tratamiento por complicaciones y falleció. Son muy pocos los casos publicados de linfoma primario del sistema nervioso central asociado a lupus eritematoso sistémico. Abstract in english A 36 year-old woman with systemic lupus erythematosus was admitted to our hospital with headache, brachiocrural hemiparesis and hemianesthesia. She had been treated with prednisone and cyclophosphamide. CT scan and MRI revealed a 15 mm nodular mass enhanced with gadolinium in left frontal convexity. [...] CNS biopsy was performed and a diffuse large B-cell lymphoma was diagnosed. She was treated with radiation therapy without response and died. There are few reports of erythematosus systemic lupus associated with primary central nervous system lymphoma.

C. N., Pisoni; A. R., Grinberg; J. L., Plana; R. D., Freue; J. A., Manni; L., Paz.

2003-06-01

274

Do current indications for surgery of primary gastric lymphoma exist? / ¿Existen indicaciones actuales para la cirugía en el linfoma gástrico?  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: English Abstract in spanish Objetivo: analizar los resultados de nuestra serie a fin de establecer si la extirpación quirúrgica continúa siendo una opción terapéutica válida para las situaciones en las que pudiera precisarse cirugía. Como objetivo secundario, analizar la prevalencia de infección por Helicobacter pylori. Pacien [...] tes y método: estudio retrospectivo de 69 pacientes consecutivos diagnosticados de linfoma gástrico primario, en estadio I E y II E de Ann Arbor, 65 de los cuales fueron tratados mediante gastrectomía entre 1974 y 1999. Edad media: 62,6 años (28-85). En 60 casos se revisó la histología de la pieza de resección con nuevas tinciones (hematoxilina-eosina, Giemsa), y estudio inmunohistoquímico de los bloques de parafina. La clasificación histológica se realizó de acuerdo con la clasificación de Isaacson. El análisis estadístico se realizó mediante las pruebas de Chi cuadrado y prueba exacta de Fisher y Kaplan-Meier y Log-Rank para el análisis de supervivencia. Resultados: la mortalidad fue de 9,2%. Se produjeron complicaciones no mortales en 10,8%. Se identificó Helicobacter pylori en 62,7%. Se produjo recaída en 7 pacientes (11,9%). La probabilidad de supervivencia fue de 87% a 5 años. El análisis estadístico no demostró influencia del estadio de Ann Arbor, invasión en la pared gástrica, infección por Helicobacter pylori, tipo histológico, ni afectación de bordes sobre la supervivencia. Conclusiones: la extirpación quirúrgica posibilita un alto grado de remisión completa y una excelente supervivencia a largo plazo, con mortalidad aceptable, por lo que es un tratamiento válido en caso de ausencia de diagnóstico histológico, hallazgo incidental o urgencia. Abstract in english Objective: to analyze the results of our series in order to assess whether surgical excision is still a valid therapeutic option in case the patient needs surgery. Secondarily, to analyze Helicobacter pylori infection rate. Patients and method: a retrospective study of 69 consecutive patients having [...] stage IE-IIE primary gastric lymphoma; of these, 65 were treated by gastrectomy between 1974 and 1999. Mean age: 62.6 years (28-85). New staining of paraffin-embedded samples from the surgical specimen were carried out (hematoxiline-eosine, Giemsa, immunohistochemistry) and reviewed. The histological classification was performed according to Isaacson's criteria. The statistical analysis was done by Chi-squared and Fisher's exact tests, as well as Kaplan-Meier and Log-Rank tests. Results: mortality was 9.2%. There were non-fatal complications in 10.8%. Helicobacter pylori was identified in 62.7%. Seven patients (11.9%) suffered a relapse. The 5-year survival probability was 87%. The statistical analysis did not show any influences of Ann Arbor stage, gastric wall invasion, Helicobacter pylori infection, histological type, or margin resection involvement on survival. Conclusions: surgical excision provides a high rate of complete remissions and excellent long-term survival with acceptable mortality. Therefore it appears to be a valid treatment in case of emergency surgery, incidental finding, or lack of histological diagnosis.

J. C., Rodríguez-Sanjuán; R. A., García; S., Trugeda; F. de la, Torre; J., Llorca; M., Gómez-Fleitas.

275

Calculation of intravascular signal in dynamic contrast enhanced-MRI using adaptive complex independent component analysis.  

Science.gov (United States)

Assessing tumor response to therapy is a crucial step in personalized treatments. Pharmacokinetic (PK) modeling provides quantitative information about tumor perfusion and vascular permeability that are associated with prognostic factors. A fundamental step in most PK analyses is calculating the signal that is generated in the tumor vasculature. This signal is usually inseparable from the extravascular extracellular signal. It was shown previously using in vivo and phantom experiments that independent component analysis (ICA) is capable of calculating the intravascular time-intensity curve in dynamic contrast enhanced (DCE)-MRI. A novel adaptive complex independent component analysis (AC-ICA) technique is developed in this study to calculate the intravascular time-intensity curve and separate this signal from the DCE-MR images of tumors. The use of the complex-valued DCE-MRI images rather than the commonly used magnitude images satisfied the fundamental assumption of ICA, i.e., linear mixing of the sources. Using an adaptive cost function in ICA through estimating the probability distribution of the tumor vasculature at each iteration resulted in a more robust and accurate separation algorithm. The AC-ICA algorithm provided a better estimate for the intravascular time-intensity curve than the previous ICA-based method. A simulation study was also developed in this study to realistically simulate DCE-MRI data of a leaky tissue mimicking phantom. The passage of the MR contrast agent through the leaky phantom was modeled with finite element analysis using a diffusion model. Once the distribution of the contrast agent in the imaging field of view was calculated, DCE-MRI data was generated by solving the Bloch equation for each voxel at each time point. The intravascular time-intensity curve calculation results were compared to the previously proposed ICA-based intravascular time-intensity curve calculation method that applied ICA to the magnitude of the DCE-MRI data (Mag-ICA) using both simulated and experimental tissue mimicking phantoms. The AC-ICA demonstrated superior performance compared to the Mag-ICA method. AC-ICA provided more accurate estimate of intravascular time-intensity curve, having smaller error between the calculated and actual intravascular time-intensity curves compared to the Mag-ICA. Furthermore, it showed higher robustness in dealing with datasets with different resolution by providing smaller variation between the results of each datasets and having smaller difference between the intravascular time-intensity curves of various resolutions. Thus, AC-ICA has the potential to be used as the intravascular time-intensity curve calculation method in PK analysis and could lead to more accurate PK analysis for tumors. PMID:23247848

Mehrabian, Hatef; Chopra, Rajiv; Martel, Anne L

2013-04-01

276

Estratificação de risco em linfoma difuso de grandes células B Risk stratification of large B-cell lymphomas  

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Full Text Available O linfoma difuso de grandes células B (LDGCB é uma entidade clínico-patológica heterogênea que corresponde de 30% a 35% dos casos de linfoma não-Hodgkin (LNH. É considerado como agressivo porque a sobrevida é curta na ausência de tratamento adequado. Desde 1993 o tratamento deste linfoma passou a ser direcionado pelo índice internacional de prognóstico (IPI validado em vários estudos. Entretanto, diante das diferentes respostas à mesma terapêutica para pacientes de mesmo IPI houve necessidade de se instituírem novos marcadores de prognóstico para pacientes com LDGCB. Com os avanços do conhecimento biológico destes linfomas, outras variáveis começam a ser utilizadas na estratificação de risco destes linfomas. Nesta revisão abordamos os principais marcadores biológicos utilizados como fatores de prognóstico para o tratamento de pacientes com LDGCB.Diffuse large B-cell lymphoma is a heterogeneous clinical pathological entity which accounts for about 30% to 35% of all non-Hodgkin's lymphoma cases. It is considered to be aggressive due to the patient's short survival time when incorrect treatment is provided. Since 1993, treatment has been carried out according to IPI, which has been validated in several studies. However, since there are different responses from patients with the same IPI submitted to similar therapies, new prognostic markers are needed for these patients. As the biological nature of such lymphomas is becoming better known, other variables are starting to be used in order to stratify risk. In this review we will approach the key biological markers used as prognostic factors to treat diffuse Large B-Cell Lymphoma patients.

Abrahão E. Hallack Neto

2006-12-01

277

Estratificação de risco em linfoma difuso de grandes células B / Risk stratification of large B-cell lymphomas  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese O linfoma difuso de grandes células B (LDGCB) é uma entidade clínico-patológica heterogênea que corresponde de 30% a 35% dos casos de linfoma não-Hodgkin (LNH). É considerado como agressivo porque a sobrevida é curta na ausência de tratamento adequado. Desde 1993 o tratamento deste linfoma passou a [...] ser direcionado pelo índice internacional de prognóstico (IPI) validado em vários estudos. Entretanto, diante das diferentes respostas à mesma terapêutica para pacientes de mesmo IPI houve necessidade de se instituírem novos marcadores de prognóstico para pacientes com LDGCB. Com os avanços do conhecimento biológico destes linfomas, outras variáveis começam a ser utilizadas na estratificação de risco destes linfomas. Nesta revisão abordamos os principais marcadores biológicos utilizados como fatores de prognóstico para o tratamento de pacientes com LDGCB. Abstract in english Diffuse large B-cell lymphoma is a heterogeneous clinical pathological entity which accounts for about 30% to 35% of all non-Hodgkin's lymphoma cases. It is considered to be aggressive due to the patient's short survival time when incorrect treatment is provided. Since 1993, treatment has been carri [...] ed out according to IPI, which has been validated in several studies. However, since there are different responses from patients with the same IPI submitted to similar therapies, new prognostic markers are needed for these patients. As the biological nature of such lymphomas is becoming better known, other variables are starting to be used in order to stratify risk. In this review we will approach the key biological markers used as prognostic factors to treat diffuse Large B-Cell Lymphoma patients.

Abrahão E., Hallack Neto; Juliana, Pereira; Rosaura, Saboya; Beatriz, Beitler; Luis Fernando, Pracchia; Frederico L., Dulley; Dalton A. F., Chamone.

278

Imminent Cardiac Risk Assessment via Optical Intravascular Biochemical Analysis  

Energy Technology Data Exchange (ETDEWEB)

Heart disease is by far the biggest killer in the United States, and type II diabetes, which affects 8% of the U.S. population, is on the rise. In many cases, the acute coronary syndrome and/or sudden cardiac death occurs without warning. Atherosclerosis has known behavioral, genetic and dietary risk factors. However, our laboratory studies with animal models and human post-mortem tissue using FT-IR microspectroscopy reveal the chemical microstructure within arteries and in the arterial walls themselves. These include spectra obtained from the aortas of ApoE-/- knockout mice on sucrose and normal diets showing lipid deposition in the former case. Also pre-aneurysm chemical images of knockout mouse aorta walls, and spectra of plaque excised from a living human patient are shown for comparison. In keeping with the theme of the SPEC 2008 conference Spectroscopic Diagnosis of Disease this paper describes the background and potential value of a new catheter-based system to provide in vivo biochemical analysis of plaque in human coronary arteries. We report the following: (1) results of FT-IR microspectroscopy on animal models of vascular disease to illustrate the localized chemical distinctions between pathological and normal tissue, (2) current diagnostic techniques used for risk assessment of patients with potential unstable coronary syndromes, and (3) the advantages and limitations of each of these techniques illustrated with patent care histories, related in the first person, by the physician coauthors. Note that the physician comments clarify the contribution of each diagnostic technique to imminent cardiac risk assessment in a clinical setting, leading to the appreciation of what localized intravascular chemical analysis can contribute as an add-on diagnostic tool. The quality of medical imaging has improved dramatically since the turn of the century. Among clinical non-invasive diagnostic tools, laboratory tests of body fluids, EKG, and physical examination are still the first line of defense. However, with the fidelity of 64-slice CT imaging, this technique has recently become an option when the patient presents with symptoms of reduced arterial flow. Single photon emission computerized tomography (SPECT) treadmill exercise testing is a standard non-invasive test for decreased perfusion of heart muscle, but is time consuming and not suited for emergent evaluation. Once the invasive clinical option of catherization is chosen, this provides the opportunity for intravascular ultrasound (IVUS) imaging. As the probe is pulled through the artery, the diameter at different parts is measurable, and monochrome contrast in the constricted area reveals the presence of tissue with a different ultrasonic response. Also, via an optical catheter with a fiber-optic conductor, the possibly of spectroscopic analysis of arterial walls is now a reality. In this case, the optical transducer is coupled to a near-infrared spectrometer. Revealing the arterial chemical health means that plaque vulnerability and imminent risk could be assessed by the physician. The classical emergency use of catherization involves a contrast agent and dynamic X-ray imaging to locate the constriction, determine its severity, and possibly perform angioplasty, and stent placement.

Wetzel, D.; Wetzel, L; Wetzel, M; Lodder, R

2009-01-01

279

Protection against high intravascular pressure in giraffe legs  

DEFF Research Database (Denmark)

The high blood pressure in giraffe leg arteries renders giraffes vulnerable to edema. We investigated in 11 giraffes whether large and small arteries in the legs and the tight fascia protect leg capillaries. Ultrasound imaging of foreleg arteries in anesthetized giraffes and ex vivo examination revealed abrupt thickening of the arterial wall and a reduction of its internal diameter just below the elbow. At and distal to this narrowing, the artery constricted spontaneously and in response to norepinephrine and intravascular pressure recordings revealed a dynamic, viscous pressure drop along the artery. Histology of the isolated median artery confirmed dense sympathetic innervation at the narrowing. Structure and contractility of small arteries from muscular beds in the leg and neck were compared. The arteries from the legs demonstrated an increased media thickness-to-lumen diameter ratio, increased media volume, and increased numbers of smooth muscle cells per segment length and furthermore, they contracted more strongly than arteries from the neck (500 ± 49 vs. 318 ± 43 mmHg; n = 6 legs and neck, respectively). Finally, the transient increase in interstitial fluid pressure following injection of saline was 5.5 ± 1.7 times larger (n = 8) in the leg than in the neck. We conclude that 1) tissue compliance in the legs is low; 2) large arteries of the legs function as resistance arteries; and 3) structural adaptation of small muscle arteries allows them to develop an extraordinary tension. All three findings can contribute to protection of the capillaries in giraffe legs from a high arterial pressure.

Petersen, Karin K; HØrlyck, Arne

2013-01-01

280

Fibronectin: blood turnover in normal animals and during intravascular coagulation  

International Nuclear Information System (INIS)

Plasma fibronectin (FN) binds fibrin in vitro by both noncovalent and covalent bonds and is decreased in DIC. In rabbits, conventionally purified 125I-FN had a complex blood clearance with a late t1/2 of 71 hr. A large portion was apparently altered, as evinced by rapid clearance and an intravascular/total body ratio (C1) of 0.28-0.51. 3H-labeled FN, made in vivo by injection of 3H amino acids, had a t1/2 of 73 hr. Crosstransfusion of 131I-FN and 3H-FN into a second set of animals gave similar t1/2s and C1s of 0.74-0.82, indicating the altered 125-FN was biologically screened in the first animals. Other animals were given 125I-fibrinogen and screened 131I-FN. Intravenous thrombin (50-60 U/kg/1 hr) caused a 25%-50% decrease in both 125I-fibrinogen and 131I-FN. Ancrod injection reduced fibrinogen by greater than 90% but had no effect on 131I-FN. 131I-FN levels did not change when thrombin was given after ancrod. No cross-linked FN-fibrinogen alpha-chain was found in the plasma, nor was the thrombin-induced fall in FN affected by spermidine blockade. These experiments demonstrate that FN and fibrin bind in vivo during defibrination and are rapidly cleared from the blood. The abnormal fibrin resulting from ancrod either does not bind FN in vivo or does so reversibly

 
 
 
 
281

Possible role of intravascular coagulation in radiation nephritis  

International Nuclear Information System (INIS)

Thrombosis contributes to pathogenic mechanisms of such late effects as organ fibrosis and premature atherosclerosis. Recently deposition of fibrin in kidney glomeruli was postulated to be of possible significance for radiation nephritis. Results of the following studies support this view. A generalized Schwartzman reaction was provoked in 24 rabbits by a single dose of 50 ?g of endotoxin (Salmonella enteritidis, Lipopolysaccharide B, Difco) administered 24 h after whole-body exposure to 850 R of X-rays. This procedure induced similar laboratory signs of intravascular coagulation and somewhat more pronounced fibrin deposition in kidneys compared with a group (28 rabbits) treated in a classical manner, i.e. with two doses of endotoxin spaced by a 24 h interval. In about two-thirds of 29 patients with uterine carcinoma, fibrin degradation products (FDP) appeared in urine during treatment with radium and 60Co. Since kidneys were exposed to only negligible doses of radiation under the applied conditions of therapy, experiments in dogs were performed aimed at elucidating the significance of direct renal exposure. Fractionated doses (19 x 400 R, 5 weeks) of X-rays were given to either the kidney or mediastinum region. Irradiation resulted in a pronounced increase in serum FDP and the appearance of FDP in the urine. The character and dynamics of changes were similar in both groups regardless of whether kidneys or mediastinum were exposed. Results of other coagulaum were exposed. Results of other coagulation tests and histological examinations indicate that radiation induces systemic activation of blood coagulation and renal deposition of fibrin. Kidneys can be involved in this process in an indirect way. (author)

282

La crítica de Hicks al Tratado del Dinero de Keynes  

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Full Text Available El objetivo de este artículo es mostrar que la crítica que hace Hicks al Tratado del Dinero de Keynes es incorrecta. Para ello, presentamos el modelo de Keynes, mostrando que la igualdad entre la inversión y el ahorro es una condición de equilibrio monetario y no una identidad. Este resultado no puede ser obtenido en el análisis de Hicks.

Alexander Tobón

2004-12-01

283

El sistema del Tratado Antártico en sus bodas de oro  

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Full Text Available Del pasado al presente ... y hacia el futuro. Una inédita maquinaria provocadora y desafiante. Las partes como protagonistas. Las reuniones consultivas del Tratado Antártico como eje del sistema. Propósitos y principios. Las forzosas nueva convenciones. Los órganos complementarios. Conclusiones

Roberto Puceiro Ripol

2014-03-01

284

Medio ambiente en el Tratado de Libre Comercio  

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Full Text Available Se muestran las relaciones entre la dinámica del medio ambiente y el libre comercio con ocasión de la entrada del Tratado de Libre Comercio TLC de Colombia con los Estados Unidos. Se presentan las dos posturas tanto ambientalista como comercialista y escenarios de conciliación de las mismas.

Juan Pablo Galeano Rey

2006-01-01

285

Nonlinear dynamic characteristics of SMA intravascular stent under radial stochastic loads.  

Science.gov (United States)

Nonlinear dynamic characteristics of shape memory alloy (SMA) intravascular stent under radial stochastic loads were studied in this paper. Von de Pol item was improved to interpret the hysteretic phenomena of SMA, and the nonlinear dynamic model of SMA intravascular stent under radial stochastic loads was developed. The conditions of stochastic stability of the system were obtained in singular boundary theory. The steady-state probability density function of the dynamic response of the system was given, and the stochastic Hopf bifurcation characteristics of the system were analyzed. Theoretical analysis and numerical simulation show that the stability of the trivial solution varies with bifurcation parameters, and stochastic Hopf bifurcation appears in the process, which can cause stent fracture or loss. The results of this paper are helpful to application of SMA intravascular stent in biomedical engineering fields. PMID:24211931

Zhu, Zhiwen; Zhang, Qingxin; Xu, Jia

2014-01-01

286

Research of epidermal cellular vegetal cycle of intravascular low level laser irradiation in treatment of psoriasis  

Science.gov (United States)

Objective: To research epidermal cellular vegetal cycle and the difference of DNA content between pre and post Intravascular Low Level Laser Irradiation treatment of psoriasis. Method: 15 patients suffered from psoriasis were treated by intravascular low level laser irradiation (output power: 4-5mw, 1 hour per day, a course of treatment is 10 days). We checked the different DNA content of epidermal cell between pre and post treatment of psoriasis and 8 natural human. Then the percentage of each phase among the whole cellular cycle was calculated and the statistical analysis was made. Results: The mean value of G1/S phase is obviously down while G2+M phase increased obviously. T test Ppsoriasis is effective according to the research of epidermal cellular vegetal cycle and the difference DNA content of Intravascular Low Level Laser Irradiation between pre and post treatment of psoriasis

Zhu, Jing; Bao, Xiaoqing; Zhang, Mei-Jue

2005-07-01

287

Intravascular lymphoma presenting as a specific pulmonary embolism and acute respiratory failure: a case report  

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Full Text Available Abstract Introduction The occurrence of an intravascular lymphoma with severe pulmonary involvement mimicking pulmonary embolism is described. Case presentation A 38-year-old man was referred to our intensive care unit with acute respiratory failure and long lasting fever. Appropriate investigations failed to demonstrate any bacterial, viral, parasitic or mycobacterial infection. A chest computed tomography scan ruled out any proximal or sub-segmental pulmonary embolism but the ventilation/perfusion lung scan concluded that there was a high probability of pulmonary embolism. The cutaneous biopsy pathology diagnosed intravascular lymphoma. Conclusion Intravascular lymphoma is a rare disease characterized by exclusive or predominant growth of neoplastic cells within the lumina of small blood vessels. Lung involvement seems to be common, but predominant lung presentation of this disease is rare. In our patient, urgent chemotherapy, along with adequate supportive care allowed complete recovery.

Georgin-Lavialle Sophie

2009-05-01

288

Accumulation of /sup 99m/Tc-sulfur colloid by the lung and kidney following disseminated intravascular coagulation  

International Nuclear Information System (INIS)

A patient is described who demonstrated accumulation of /sup 99m/Tc-sulfur colloid in both the lung and kidney following treatment for disseminated intravascular coagulation. This phenomenon has been demonstrated experimentally in animals following the induction of disseminated intravascular coagulation, but to our knowledge has not been previously described in humans

289

Accumulation of /sup 99m/Tc-sulfur colloid by the lung and kidney following disseminated intravascular coagulation  

Energy Technology Data Exchange (ETDEWEB)

A patient is described who demonstrated accumulation of /sup 99m/Tc-sulfur colloid in both the lung and kidney following treatment for disseminated intravascular coagulation. This phenomenon has been demonstrated experimentally in animals following the induction of disseminated intravascular coagulation, but to our knowledge has not been previously described in humans.

Smith, F.W.; Brown, R.G.; Ash, J.M.; Gilday, D.L.

1980-06-01

290

Linfoma primario cutáneo difuso de células B grandes, tipo pierna (LPCDCBG-TP, localizado en cuero cabelludo Diffuse primary large B-Cell cutaneous lymphoma  

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Full Text Available Los linfomas primarios cutáneos de células B se consideran actualmente como categoría distintiva de los linfomas primarios cutáneos y se reconocen subtipos característicos dentro de ellos. Se presenta un caso de linfoma primario cutáneo difuso de células B grandes, tipo pierna, con localización en el cuero cabelludo, donde se pudo disponer de estudios inmunohistoquímicos para su tipificación, que mostraron positividad para los marcadores CD20, bcl-2 y MUM-1, y negatividad para CD3 y bcl-6. Estos resultados, unidos a las características de las lesiones y el estudio histológico condujeron al diagnóstico final.Los linfomas primarios cutáneos de células B se consideran actualmente como categoría distintiva de los linfomas primarios cutáneos y se reconocen subtipos característicos dentro de ellos. Se presenta un caso de linfoma primario cutáneo difuso de células B grandes, tipo pierna, con localización en el cuero cabelludo, donde se pudo disponer de estudios inmunohistoquímicos para su tipificación, que mostraron positividad para los marcadores CD20, bcl-2 y MUM-1, y negatividad para CD3 y bcl-6. Estos resultados, unidos a las características de las lesiones y el estudio histológico condujeron al diagnóstico final.

Oristel I Felipe Fereira

2010-06-01

291

Recent acquisitions in the pathophysiology, diagnosis and treatment of disseminated intravascular coagulation  

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Full Text Available Abstract Disseminated intravascular coagulation (DIC is a disorder characterized by both acute generalized, widespread activation of coagulation, which results in thrombotic complications due to the intravascular formation of fibrin, and diffuse hemorrhages, due to the consumption of platelets and coagulation factors. Systemic activation of coagulation may occur in a variety of disorders, including sepsis, severe infections, malignancies, obstetric or vascular disorders, and severe toxic or immunological reactions. In this review, we briefly report the present knowledge about the pathophysiology and diagnosis of DIC. Particular attention is also given to the current standard and experimental therapies of overt DIC.

Lippi Giuseppe

2006-02-01

292

High frequency intravascular photoacoustic (IVPA) imaging for differentiating arterial wall layered structures  

Science.gov (United States)

Arterial wall is composed of three layers: intima, media and adventitia. Intima-media thickness (IMT) is an important prognostic indicator of atherosclerotic diseases. Although intravascular ultrasound (IVUS) imaging is a commonly used method for delineation of the layered structures, it is inferior to the optical absorption contrast offered by intravascular photoacoustic (IVPA) imaging. We introduce an integrated miniature probe that combines the capabilities of IVUS and IVPA imaging for the evaluation of arterial wall layered structures. Healthy rabbit aorta was imaged ex vivo. IVPA results showed superior contrast over IVUS in identifying the layered structures of arterial wall.

Li, Xiang; Wei, Wei; Zhou, Qifa; Shung, K. Kirk; Chen, Zhongping

2012-02-01

293

Image segmentation and tissue characterization in three-dimensional intravascular ultrasound images  

Science.gov (United States)

In this paper, we report an automated approach to plaque tissue characterization in three-dimensional intravascular ultrasound images. Our previously reported automated method for coronary wall and plaque segmentation in intravascular ultrasound pullback sequences represent the first step of the method. Tissue characterization into two classes of soft and hard plaque is based on texture analysis and pattern recognition. Texture description features included gray- level-based measures, co-occurrence matrices, run length measures, and fractal-based measures. Performance of the method was assessed in cadaveric coronary arteries by comparison to the observer-defined plaque composition. Overall classification correctness of 90% was achieved.

Zhang, Xiangmin; DeJong, Steven C.; McKay, Charles R.; Sonka, Milan

1997-04-01

294

Endoscopic intravascular esophageal pressure measurements in cirrhotic patients: response to metoclopramide.  

Science.gov (United States)

This study reports the effects of metoclopramide (10 mg i.v.) on intravascular esophageal variceal pressure in 12 patients with alcoholic cirrhosis. The esophageal variceal pressure was measured by the direct variceal puncture technique. Metoclopramide caused a reduction in the variceal pressure in 10 out of 12 patients; overall, there was a decrease from 21.5 +/- 5.0 mmHg to 14.0 +/- 3.4 mmHg (p < 0.001). In conclusion, intravenous metoclopramide, which increases lower esophageal sphincter pressure, significantly decreases intravascular variceal pressure in cirrhotic patients. PMID:8509050

Stanciu, C; Cijevschi, C; Stan, M; Sandulescu, E

1993-04-01

295

[Asphyxial shock and disseminated intravascular coagulation (DIC) in animal experiments. 1. Histological picture (author's transl)].  

Science.gov (United States)

The effects of subacute intra-uterine hypoxia on the haemostatic system of 205 foetuses from 49 pregnant rabbits were studied by a standardised experimental arrangement, with particular reference being made to intravascular precipitation of fibrin. The asphyxial shock thus induced was accompanied by almost all the rabbit foetuses by disseminated intravascular coagulation by which the central organs were more strongly affected, as compared to peripheral organs also restricted by the shock. The pathophysiological processes which were found to take place in the lungs and placentas of the experimental animals proved different from those in man, which was attributable to species-related differences. PMID:7456878

Niedner, W; Schmidt, D; Genzel, U; Laube, R; Hofmann, K D

1980-01-01

296

Intravascular brachytherapy in prevention of the secondary restenosis angioplasty transluminal coronaries  

International Nuclear Information System (INIS)

The radiotherapy coronary intravascular has demonstrated in a convincing way in clinical and experimental studies that produces a favorable decrease of the restenosis process. There is enough evidence to define this technique as the main current therapeutic option in the handling of the reestenosis intra stent. Accumulated experience exists of up to 3 years in patient's treaties with radiation gamma and multiple studies in several centers that demonstrate similar benefits with issuing beta. The present articulates it revises a series of radiotherapy systems and makes a setting a day on the employment of the brachytherapy intravascular in cardiologic patient

297

Coagulación intravascular diseminada fulminante en una paciente con leucemia promielocítica aguda  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Se comunicó el caso de una paciente con diagnóstico de coagulación intravascular diseminada, de tipo fulminante, cuya causa resultó ser una leucemia promielocítica aguda, de la variedad hipergranular. Se observó, clínicamente, un comportamiento agresivo de la enfermedad que ocasionó la muerte del pa [...] ciente, en 72 h, por hemorragias viscerales masivas. Abstract in english The case of a patient with diagnosis of fulminant disseminated intravascular coagulation caused by a hypergranular acute promyelocytic leukaemia was reported. An aggressive behavior of the disease that caused the death of the patient in 72 hours due to visceral massive hemorrhages was clinically obs [...] erved.

Ivette, Martínez López; Jorge, Jiménez Armada; Martha, Ballmajó Real; Reynaldo William, Sánchez García; Manuel, Solano Rolando.

2002-10-01

298

Coagulación intravascular diseminada fulminante en una paciente con leucemia promielocítica aguda  

Directory of Open Access Journals (Sweden)

Full Text Available Se comunicó el caso de una paciente con diagnóstico de coagulación intravascular diseminada, de tipo fulminante, cuya causa resultó ser una leucemia promielocítica aguda, de la variedad hipergranular. Se observó, clínicamente, un comportamiento agresivo de la enfermedad que ocasionó la muerte del paciente, en 72 h, por hemorragias viscerales masivas.The case of a patient with diagnosis of fulminant disseminated intravascular coagulation caused by a hypergranular acute promyelocytic leukaemia was reported. An aggressive behavior of the disease that caused the death of the patient in 72 hours due to visceral massive hemorrhages was clinically observed.

Ivette Martínez López

2002-10-01

299

Síndrome hemofagocítico y linfoma cutáneo de células T / Haemophagocytic syndrome and cutaneous T-cell lymphoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish El síndrome hemofagocítico (SHF) es un trastorno infrecuente de la inmunorregulación, cuyas manifestaciones clínicas son fiebre, hemofagocitosis, hepatoesplenomegalia, pancitopenia, linfadenopatías, hipertrigliceridemia y coagulopatía. Puede cursar también con afectación pulmonar, fracaso renal agud [...] o o síndrome de secreción inadecuada de ADH (SIADH). Se ha descrito asociado a múltiples enfermedades, destacando los linfomas, sobre todo de células T, infecciones y enfermedades sistémicas, entre otras entidades. Las células hematopoyéticas son fagocitadas por monocitos y macrófagos en los ganglios linfáticos, médula ósea, hígado y bazo, lo que constituye un criterio diagnóstico del SHF. El tratamiento es difícil e incluye medidas de soporte y de las alteraciones de coagulación así como corticoides sistémicos a altas dosis e inmunosupresores, aunque en la mayoría de ocasiones no hay respuesta al tratamiento y la evolución es fatal. Los linfomas T que afectan al tejido celular subcutáneo y simulan una paniculitis han sido clasificados recientemente como linfomas cutáneos de células T (LCCT), siendo infrecuente su presentación como nódulos inflamatorios en extremidades inferiores. Abstract in english Haemophagocytic syndrome is a rare disorder of immune regulation. Clinical features are fever, haemophagocytosis, hepatosplenomegaly, pancitopenia, lymph nodes enlargement, hypertriglyceridaemia and coagulopaty. Systemic findings may also include pulmonary infiltrates, renal failure and an inappropr [...] iate antidiuretic state. It has been described associated to many diseases, like lymphomas, most of them T-cell lymphomas, infections and systemic diseases, among other entities. Haemopoietic cells are actively ingested by monocites and macro-phages in lymph nodes, bone marrow, liver and spleen. This is a diagnostic criteria for haemophagocytic syndrome. The treatment of Haemophagocytic syndrome is difficult and requires intensive supportive therapy, treatment of coagulopaty disorders, high-dose corticosteroids and immunosuppressive treatment, although in most cases there is no response to treatment and the evolution is fatal. The T-cell lymphomas that involve subcutaneous tissue and simulate panniculitis are classified recently as primary cutaneous T-cell lymphomas, and their presentation as inflammatory nodules of the legs are uncommon.

A., Artigues Barceló; M., Ferragut Reus; C., Sánchez; I., Amengual; I., Matanza; M. S., Sanz Parras.

300

Linfoma primario de bazo. Presentación de un caso / Primary lymphoma of the spleen. Case presentation  

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Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Fundamento: en el bazo se pueden observar diferentes tipos de tumores, dentro de los cuales están los linfomas primarios del mismo, enfermedad infrecuente, de ahí la importancia de su presentación. Presentación de caso: paciente femenina de 66 años, raza blanca, con antecedentes de hipertensión arte [...] rial, lobectomía derecha del tiroides, que refiere venía presentando desde hacía más de un año dolor abdominal alto izquierdo que se hacía más intenso tras el esfuerzo físico, tos, presentando toma del estado general por lo que se ingresa en el servicio de cirugía. Se toman muestras para biopsia, después de ser intervenido quirúrgicamente de una esplenectomía, dando como resultado un Linfoma no Hodgkin de células grandes CD20 positivo, sin infiltración hepática, ganglionar ni epiplóica. Se realizó esplenectomía y quimioterapia. La paciente ha evolucionado favorablemente. Conclusiones: el linfoma primario de bazo es una entidad infrecuente y su diagnóstico es aún más raro en pacientes por encima de los 60 años, como ocurrió en el caso presentado. A medida que casos como este se divulguen entre los profesionales de la salud permitirán una aproximación diagnóstica más precisa a esta enfermedad poco común. Abstract in english Background: in the spleen you can see different types of tumors; primary lymphomas are an example of them. This is an infrequent disease, hence the importance of its presentation. Case presentation: 66 year old white female patient with history of hypertension, thyroid right lobectomy that refers to [...] have been suffering from high left abdominal pain for a year that became more intense after physical exertion, cough, presenting general malaise by what is admitted to the surgical service. Some samples for biopsy are taken, after being surgically operated of a splenectomy, showing as a result a non-Hodkin lymphoma of big cells resulting cell non-Hodgkin lymphoma CD20 Positive, without hepatic, ganglionic or epiploic infiltration. Splenectomy and chemotherapy were made. The patient has improved favorably. Conclusions: primary lymphoma of the spleen is a rare entity and its diagnosis is still rarer in patients over 60 years, as it happened in the case presented. As cases like these are disseminated among health professionals will allow a more accurate diagnostic approach to this rare disease.

Vicente Joaquín, Más Medina; Mirelquis, Rodríguez Rodríguez; Ania Inés, Cuellar Armas; Ariana Ofelia, Gómez Mutis; Ramsés Manuel, Más Herrera.

2013-12-01

 
 
 
 
301

Linfoma primario de bazo. Presentación de un caso / Primary lymphoma of the spleen. Case presentation  

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Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Fundamento: en el bazo se pueden observar diferentes tipos de tumores, dentro de los cuales están los linfomas primarios del mismo, enfermedad infrecuente, de ahí la importancia de su presentación. Presentación de caso: paciente femenina de 66 años, raza blanca, con antecedentes de hipertensión arte [...] rial, lobectomía derecha del tiroides, que refiere venía presentando desde hacía más de un año dolor abdominal alto izquierdo que se hacía más intenso tras el esfuerzo físico, tos, presentando toma del estado general por lo que se ingresa en el servicio de cirugía. Se toman muestras para biopsia, después de ser intervenido quirúrgicamente de una esplenectomía, dando como resultado un Linfoma no Hodgkin de células grandes CD20 positivo, sin infiltración hepática, ganglionar ni epiplóica. Se realizó esplenectomía y quimioterapia. La paciente ha evolucionado favorablemente. Conclusiones: el linfoma primario de bazo es una entidad infrecuente y su diagnóstico es aún más raro en pacientes por encima de los 60 años, como ocurrió en el caso presentado. A medida que casos como este se divulguen entre los profesionales de la salud permitirán una aproximación diagnóstica más precisa a esta enfermedad poco común. Abstract in english Background: in the spleen you can see different types of tumors; primary lymphomas are an example of them. This is an infrequent disease, hence the importance of its presentation. Case presentation: 66 year old white female patient with history of hypertension, thyroid right lobectomy that refers to [...] have been suffering from high left abdominal pain for a year that became more intense after physical exertion, cough, presenting general malaise by what is admitted to the surgical service. Some samples for biopsy are taken, after being surgically operated of a splenectomy, showing as a result a non-Hodkin lymphoma of big cells resulting cell non-Hodgkin lymphoma CD20 Positive, without hepatic, ganglionic or epiploic infiltration. Splenectomy and chemotherapy were made. The patient has improved favorably. Conclusions: primary lymphoma of the spleen is a rare entity and its diagnosis is still rarer in patients over 60 years, as it happened in the case presented. As cases like these are disseminated among health professionals will allow a more accurate diagnostic approach to this rare disease.

Vicente Joaquín, Más Medina; Mirelquis, Rodríguez Rodríguez; Ania Inés, Cuellar Armas; Ariana Ofelia, Gómez Mutis; Ramsés Manuel, Más Herrera.

302

Características clínicas y resultados terapéuticos de linfomas no Hodgkin de células grandes B mediastinal primarios Clinical features and therapeutic results of primary mediastinal large B- cells non-Hodgkin's lymphomas  

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Full Text Available Se realizó un estudio observacional, descriptivo y retrospectivo para evaluar las características clinicobiológicas y los resultados terapéuticos del linfoma de células grandes B mediastinal primario, en 34 pacientes atendidos en el Hospital Clinicoquirúrgico "Hermanos Ameijeiras" desde junio de 1989 a febrero de 2009. Se halló predominio del sexo femenino (61,8 %, edad promedio de 31,5 años (19 a 61 años y de la raza blanca (70,6 %. Fueron más frecuentes los estadios localizados (67,7 %, sin síntomas B (64,7 % y con gran masa tumoral (70,6 %. La supervivencia global y la supervivencia libre de progresión a los 5 años fueron 53,4 y 43,4 %, respectivamente. La supervivencia global a los 3 años de los pacientes tratados con MACOPB/VACOPB, CHOP y R-CHOP fue de 77,7; 30,4 y 100 %, respectivamente. Se comprobó que los pacientes tratados con MACOPB/VACOPB tuvieron mejores resultados que los tratados con CHOP. El índice pronóstico internacional ajustado a la edad no fue predictor de supervivencia. En el análisis multivariable, el único predictor de supervivencia fue el tratamiento utilizado (CHOP contra MACOPB. El uso rutinario de la radioterapia no tuvo impacto significativo en la supervivencia global ni en la supervivencia libre de progresión a los 5 años.A retrospective, descriptive and observational study was conducted to assess the clinical-biological features and the therapeutic results of the primary mediastinal of large B cells lymphoma in 34 patients seen in the "Hermanos Ameijeiras" Clinical Surgical Hospital from June, 1989 to February, 2009. There was predominance of female sex (61.8 %, mean age of 31.5 years (19 to 61 years and of white race (70.6 %. The localized stages were more frequent (67.7 %, without B symptoms (64.7 % and with a large tumor mass (70.6 %. Global survival and the free of progression survival at five years were of 53.4 and 43.4 %, respectively. The global survival at three years of the patients treated with MACOPB/VACOPB, CHOP and R-CHOP was of 77.7; 30.4 and 100 %, respectively. It was proved that patients treated with MACOPB/VACOPB had better results than those treated with CHOP. Age-adjusted international prognostic rate was not a survival predictor. In multivariable analysis, the only survival predictor was the applied (CHOP versus MACOPB. The routine use of radiotherapy has neither a significant impact on the global survival nor on the free of progression survival at five years.

Reysel Chávez Medina

2011-06-01

303

Características clínicas y resultados terapéuticos de linfomas no Hodgkin de células grandes B mediastinal primarios / Clinical features and therapeutic results of primary mediastinal large B- cells non-Hodgkin's lymphomas  

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Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Se realizó un estudio observacional, descriptivo y retrospectivo para evaluar las características clinicobiológicas y los resultados terapéuticos del linfoma de células grandes B mediastinal primario, en 34 pacientes atendidos en el Hospital Clinicoquirúrgico "Hermanos Ameijeiras" desde junio de 198 [...] 9 a febrero de 2009. Se halló predominio del sexo femenino (61,8 %), edad promedio de 31,5 años (19 a 61 años) y de la raza blanca (70,6 %). Fueron más frecuentes los estadios localizados (67,7 %), sin síntomas B (64,7 %) y con gran masa tumoral (70,6 %). La supervivencia global y la supervivencia libre de progresión a los 5 años fueron 53,4 y 43,4 %, respectivamente. La supervivencia global a los 3 años de los pacientes tratados con MACOPB/VACOPB, CHOP y R-CHOP fue de 77,7; 30,4 y 100 %, respectivamente. Se comprobó que los pacientes tratados con MACOPB/VACOPB tuvieron mejores resultados que los tratados con CHOP. El índice pronóstico internacional ajustado a la edad no fue predictor de supervivencia. En el análisis multivariable, el único predictor de supervivencia fue el tratamiento utilizado (CHOP contra MACOPB). El uso rutinario de la radioterapia no tuvo impacto significativo en la supervivencia global ni en la supervivencia libre de progresión a los 5 años. Abstract in english A retrospective, descriptive and observational study was conducted to assess the clinical-biological features and the therapeutic results of the primary mediastinal of large B cells lymphoma in 34 patients seen in the "Hermanos Ameijeiras" Clinical Surgical Hospital from June, 1989 to February, 2009 [...] . There was predominance of female sex (61.8 %), mean age of 31.5 years (19 to 61 years) and of white race (70.6 %). The localized stages were more frequent (67.7 %), without B symptoms (64.7 %) and with a large tumor mass (70.6 %). Global survival and the free of progression survival at five years were of 53.4 and 43.4 %, respectively. The global survival at three years of the patients treated with MACOPB/VACOPB, CHOP and R-CHOP was of 77.7; 30.4 and 100 %, respectively. It was proved that patients treated with MACOPB/VACOPB had better results than those treated with CHOP. Age-adjusted international prognostic rate was not a survival predictor. In multivariable analysis, the only survival predictor was the applied (CHOP versus MACOPB). The routine use of radiotherapy has neither a significant impact on the global survival nor on the free of progression survival at five years.

Reysel, Chávez Medina; José, Carnot Uria; Raúl, de Castro Arenas; Jorge, Muñío Perurena; Guillermo, Pérez Román; Aramís, Núñez Quintana.

304

Aplicação do índice prognóstico internacional em pacientes com linfoma difuso de grandes células B em uma instituição brasileira / The use of the international prognostic index in a Brazilian institution for patients suffering from diffuse large B-cell lymphoma  

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Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese O linfoma difuso de grandes células B (LDGCB) corresponde a 50% dos casos de linfoma não-Hodgkin (LNH). A partir de 1993, o tratamento destes pacientes passou a ser direcionado pelo Índice Internacional de Prognóstico (IPI) validado em vários estudos. Entretanto a aplicação do IPI ainda não foi aval [...] iada em nossa população e em nossas condições socioeconômicas. Neste estudo avaliamos o impacto do IPI ajustado para a idade (IPIa) na remissão completa (RC), sobrevida global (SG) e sobrevida livre de doença (SLD) dos portadores de LDGCB com idade inferior a 60 anos, tratados no Serviço de Hematologia do HCFMUSP. Dos 111 pacientes avaliados, 60 foram classificados com IPIa de risco baixo e intermediário e 51 IPIa de risco intermediário alto e alto. Os pacientes de risco baixo e intermediário foram analisados em conjunto no grupo de baixo risco adaptado e os de risco intermediário alto e alto no grupo de alto risco adaptado. Verificamos que a SG e a SLD foram influenciadas pelo estádio clínico, DHL e o estado funcional dos pacientes. Recomendamos o uso sistemático do IPI no tratamento dos nossos pacientes com LDGCB em nossa instituição. Abstract in english Diffuse Large B-Cell Lymphomas (DLBCL) correspond to 50% of non-Hodgkin's lymphomas. Since 1993 the treatment of these patients has been directed by the International Prognostic Index (IPI), validated in several studies. However, the use of the IPI has not been evaluated in our population and social [...] -economical conditions. In this study, we evaluate the impact of the age-adapted IPI (aIPI) in the complete response, overall survival and disease-free survival in under 60-year-old DLBCL sufferers treated in the Hematology Service of HCFMUSP. Of the 111 evaluated patients, 60 were classified as aIPI low and intermediate risk and 51 as aIPI intermediate-high and high risk. The patients with low and intermediate risk were analyzed as a whole with adapted low risk and patients with intermediate-high and high risk with the adapted high risk. We verified that the overall survival and disease-free survival were influenced by the clinic stage, LDH value and patients performance status. We recommend the regular use of IPI in the treatment of the patients with DLBCL in our institution.

Abrahão E., Hallack Neto; Juliana, Pereira; Pedro, Dorlhiac-Llacer; Beatriz, Beitler; Dalton A. F., Chamone.

305

SEPSIS-ASSOCIATED DISSEMINATED INTRAVASCULAR COAGULATION AND THROMBOEMBOLIC DISEASE  

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Sepsis is almost invariably associated with haemostatic abnormalities ranging from subclinical activation of blood coagulation (hypercoagulability, which may contribute to localized venous thromboembolism, to acute disseminated intravascular coagulation (DIC, characterized by massive thrombin formation and widespread microvascular thrombosis, partly responsible of the multiple organ dysfunction syndrome (MODS, and subsequent consumption of platelets and coagulation proteins causing, in most severe cases, bleeding manifestations. There is general agreement that the key event underlying this life-threatening sepsis complication is the overwhelming inflammatory host response to the infectious agent leading to the overexpression of inflammatory mediators. Mechanistically, the latter, together with the micro-organism and its derivatives, causes DIC by 1 up-regulation of procoagulant molecules, primarily tissue factor (TF, which is produced mainly by stimulated monocytes-macrophages and by specific cells in target tissues; 2 impairment of physiological anticoagulant pathways (antithrombin, protein C pathway, tissue factor pathway inhibitor, which is orchestrated mainly by dysfunctional endothelial cells (ECs; and 3 suppression of fibrinolysis due to increased plasminogen activator inhibitor-1 (PAI-1 by ECs and likely also to thrombin-mediated  activation of thrombin-activatable fibrinolysis inhibitor (TAFI. Notably, clotting enzymes non only lead to microvascular thrombosis but can also elicit cellular responses that amplify the inflammatory reactions. Inflammatory mediators can also cause, directly or indirectly, cell apoptosis or necrosis and recent evidence indicates that products released from dead cells, such as nuclear proteins (particularly extracellular histones, are able to propagate further inflammation, coagulation, cell death and MODS. These insights into the pathogenetic mechanisms of DIC and MODS may have important implications for the development of new therapeutic agents that could be potentially useful particularly for the management of severe sepsis.

Concetta T. Ammollo

2010-08-01

306

Linfoma não-Hodgkin envolvendo tonsila palatina: relato de 3 casos  

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Full Text Available O objetivo deste trabalho consiste em relatar três casos de linfoma não-Hodgkin (LNH com acometimento de tonsilas palatinas acompanhados no Hospital Universitário Clementino Fraga Filho (HUCFF da Universidade Federal do Rio de Janeiro (UFRJ, com pequena revisão de literatura. Os LNH acometem sítios extra-nodais em 25-30% dos casos. Dos casos extra-nodais, 10-30% acometem cabeça e pescoço. Destes casos de LNH em cabeça e pescoço, 60-70% estão presentes no anel de Waldeyer, e deste grupo, algumas séries relatam que 80% encontram-se na tonsila palatina. Concluímos, portanto, que o acometimento das tonsilas pelo LNH constitui uma apresentação incomum desta malignidade hematológica, que merece atenção e destaque para que seja feito diagnóstico precoce, seguido de tratamento e acompanhamento corretos.

Pinto Patrícia Ciminelli Linhares

2004-01-01

307

Psoriasis, lymphoma and etanercept: is there a correlation? / Psoríase, linfoma e etanercepte: existe correlação?  

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Full Text Available SciELO Brazil | Language: English Abstract in portuguese A psoríase é uma doença inflamatória crônica que pode afetar a pele e as articulações. Seu tratamento varia conforme a gravidade e inclui medicamentos tópicos e sistêmicos. Dentre os últimos estão os imunobiológicos, que têm como alvo a célula T. Relatamos um caso que demonstra a estreita relação en [...] tre a psoríase, o linfoma e os imunobiológicos. Abstract in english Psoriasis is a chronic inflammatory disease that can affect skin and joints. Their treatment varies depending on the severity and includes topical and systemic. Among the latter are the immunobiological that target the T cell We report a case that demonstrates the close relationship between psoriasi [...] s, lymphoma and biologic therapies.

Ludmilla Queirós, Miranda; Aline Lopes, Bressan; Fernanda Valente da Silva, Rehfeldt; Bárbara Nader, Vasconcelos; Alexandre Carlos, Gripp.

308

Linfoma T primario colónico: Reporte de un caso y revisión de la literatura  

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Full Text Available SciELO Venezuela | Language: Spanish Abstract in spanish Los linfomas del tracto gastrointestinal son el tipo más frecuente de linfomas extraganglionares y de estos el 15 % a 20 % son de localización intestinal. Los linfomas colónicos primarios son extremadamente raros, comprenden 0,2 % a 0,6 % de todas las neoplasias malignas de colon. Pueden ser B o T. [...] Los tipo T son menos comunes y pueden estar o no asociados a enteropatía celiaca, enfermedad de Crohn y/o SIDA, siendo más frecuente en hombres adultos en una proporción de 2:1. Son de evolución lenta, clínicamente debutan con dolor abdominal asociado a cuadros obstructivos, seguidos de diarrea, hemorragia, perforación, o masa abdominal. El tratamiento es controvertido, en vista de que solamente el 30 % de los pacientes que van a cirugía tienen la firme presunción de linfoma. Presentamos el caso de un paciente masculino de 62 años, quien consultó por dolor abdominal en hipocondrio izquierdo de 30 días de evolución asociado a anorexia, náuseas, vómitos y melena. Los estudios de extensión gastrointestinales reportaron dentro de lo normal, en la tomografía axial computarizada abdominal se evidenció tumoración en hipocondrio izquierdo que comprimía extrínsecamente al colon descendente; siendo intervenido quirúrgicamente hallándose una gran adherencia entre epiplón mayor, peritoneo, mesocolon, ángulo esplénico, yeyuno y mesenterio, en el cual, se evidenció tumoración de 15 cm de diámetro. Se realizó una colectomía parcial y resección intestinal más anastomosis T-T, con buena evolución posoperatoria. Abstract in english Lymphomas of the gastrointestinal tract are the most frequent type of primary extranodal lymphomas and of these, the 15 % to 20 % are of intestinal location. The primary colonic lymphomas is extremely rare, they include 0.2 % to 0.6 % of all the colonic malignant neoplasm. They can be B or T. Intest [...] inal T-cell lymphomas are much less common and can be or no associate to enteropathy celiac, Crohn’s disease and/or AIDS. They are more frequent in adult men in a proportion of 2:1. They are of slow evolution, clinically they make debut with abdominal pain associate to obstructive squares, followed by diarrhea, hemorrhages, perforation or abdominal mass. The treatment is controverted, in view of which only 30 % of the patients who go to surgery have the firm presumption of lymphoma. We present the case of a 62 year-old male patient who consulted by abdominal pain in left hypochondriac of 30 days of evolution associated to anorexia, sick feeling, vomits and manes. The gastrointestinal extension studies reported normal; the Computerized Axial Tomography showed a tumor in left hypochondriac that compressed extrinsically the descending colon. The patient was under surgery finding in a great adherence among great omentun, peritoneum, mesocolon, splenic flexure, jejunum and mesentery surgically, a 15 cm diameter tumor in jejune and great omentun. We realized a partial colectomy and small intestine resection with a T-T anastomosis with a well post-operative evolution.

Gabriela, González Paredes; Estrella C, Uzcátegui Paz; Carlos E, Quintero R.

309

Psoriasis, lymphoma and etanercept: is there a correlation? / Psoríase, linfoma e etanercepte: existe correlação?  

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Full Text Available SciELO Brazil | Language: English Abstract in portuguese A psoríase é uma doença inflamatória crônica que pode afetar a pele e as articulações. Seu tratamento varia conforme a gravidade e inclui medicamentos tópicos e sistêmicos. Dentre os últimos estão os imunobiológicos, que têm como alvo a célula T. Relatamos um caso que demonstra a estreita relação en [...] tre a psoríase, o linfoma e os imunobiológicos. Abstract in english Psoriasis is a chronic inflammatory disease that can affect skin and joints. Their treatment varies depending on the severity and includes topical and systemic. Among the latter are the immunobiological that target the T cell We report a case that demonstrates the close relationship between psoriasi [...] s, lymphoma and biologic therapies.

Ludmilla Queirós, Miranda; Aline Lopes, Bressan; Fernanda Valente da Silva, Rehfeldt; Bárbara Nader, Vasconcelos; Alexandre Carlos, Gripp.

2012-02-01

310

Linfoma de Burkitt abdominal en un adolescente / Abdominal Burkitt lymphoma in an adolescent  

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Full Text Available SciELO Spain | Language: Spanish Abstract in spanish Se describe el caso clínico de un adolescente con un linfoma de Burkitt que debutó con dolor abdominal agudo. El tumor aumentó de tamaño rápidamente, se localizó mediante tomografía computarizada y se confirmó mediante estudio de la médula ósea. Se aplicaron dos protocolos quimioterápicos distintos, [...] debido a la mala evolución, pero sin resultado satisfactorio. Se hacen unas consideraciones sobre el diagnóstico diferencial, especialmente con otros tumores primarios infantiles y procesos no neoplásicos. Abstract in english We report the case of a male adolescent affected by Burkitt Lymphoma which presented as acute abdominal pain and rapid growth mass. It was characterized by computed tomography and diagnose was confirmed by bone marrow study. Two different chemotherapic regimens were used because of unfavourable evol [...] ution, but they were not successful. We consider some other causes of abdominal bulky in childhood, especially primary tumours and non tumoural diseases.

B., Fleta Asín; M. C., Gonzalvo Liarte; L., Palomera Bernal.

311

Contribuição da medicina nuclear para a avaliação dos linfomas Contribution of nuclear medicine in lymphomas approach  

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Full Text Available A medicina nuclear permite a caracterização funcional de tecidos, acrescentando dados à avaliação anatômica realizada por outros métodos de imagem, como a tomografia computadorizada, ressonância magnética ou ultra-som. Além do diagnóstico e estadiamento, as informações funcionais fornecidas pela medicina nuclear são particularmente úteis no seguimento e avaliação de resposta terapêutica dos pacientes com linfoma. A presença de massa residual após quimioterapia ou a infiltração de linfonodos de pequenas dimensões são exemplos de situações nas quais a avaliação isolada de características anatômicas é insuficiente. Os principais métodos utilizados são a cintilografia com gálio-67, traçador com alta afinidade por transferrina e receptores de ferro, e os estudos com flúor-deoxiglicose, emissor de pósitron que permite a caracterização do metabolismo de glicose nos tecidos. Outros traçadores, como o tálio-201, sestamibi-Tc99m e octreotide-In111, também são utilizados em menor escala na avaliação dos pacientes com linfoma. Os mecanismos de captação, principais indicações dos estudos, limitações e resultados de literatura serão revistos.Nuclear medicine procedures allow functional characterization of organs and tissues, that can be compared to the anatomical evaluation provided by computed tomography, magnetic resonance imaging and ultrasonography. Functional information are usefull not only in diagnosis and staging, but mainly in the follow-up and evaluation of the therapeutic response of lymphoma patients. Persistent or residual mediastinal mass and and infiltration of small nodes are some examples of situations in which purely anatomical evaluation is insufficient. The main methods in use are scintigraphy with galium-67, a transferrin avid tracer, and PET with fluoro-desoxyglucose, indicated for the metabolic evaluation of tissues. Other tracers are also described, as thallium-201, 99mTc-sestamibi, and 111In-octreotide. Mechanisms of uptake, indications, limitations and results of the literature are and discussed in this review.

Marcelo T. Sapienza

2001-08-01

312

Contribuição da medicina nuclear para a avaliação dos linfomas / Contribution of nuclear medicine in lymphomas approach  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese A medicina nuclear permite a caracterização funcional de tecidos, acrescentando dados à avaliação anatômica realizada por outros métodos de imagem, como a tomografia computadorizada, ressonância magnética ou ultra-som. Além do diagnóstico e estadiamento, as informações funcionais fornecidas pela med [...] icina nuclear são particularmente úteis no seguimento e avaliação de resposta terapêutica dos pacientes com linfoma. A presença de massa residual após quimioterapia ou a infiltração de linfonodos de pequenas dimensões são exemplos de situações nas quais a avaliação isolada de características anatômicas é insuficiente. Os principais métodos utilizados são a cintilografia com gálio-67, traçador com alta afinidade por transferrina e receptores de ferro, e os estudos com flúor-deoxiglicose, emissor de pósitron que permite a caracterização do metabolismo de glicose nos tecidos. Outros traçadores, como o tálio-201, sestamibi-Tc99m e octreotide-In111, também são utilizados em menor escala na avaliação dos pacientes com linfoma. Os mecanismos de captação, principais indicações dos estudos, limitações e resultados de literatura serão revistos. Abstract in english Nuclear medicine procedures allow functional characterization of organs and tissues, that can be compared to the anatomical evaluation provided by computed tomography, magnetic resonance imaging and ultrasonography. Functional information are usefull not only in diagnosis and staging, but mainly in [...] the follow-up and evaluation of the therapeutic response of lymphoma patients. Persistent or residual mediastinal mass and and infiltration of small nodes are some examples of situations in which purely anatomical evaluation is insufficient. The main methods in use are scintigraphy with galium-67, a transferrin avid tracer, and PET with fluoro-desoxyglucose, indicated for the metabolic evaluation of tissues. Other tracers are also described, as thallium-201, 99mTc-sestamibi, and 111In-octreotide. Mechanisms of uptake, indications, limitations and results of the literature are and discussed in this review.

Marcelo T., Sapienza; Marília M. S., Marone; Carlos S., Chiattone.

2001-08-01

313

Actinomicosis vs Linfoma: presentación de un caso / Actinomycosis vs. lymphoma: a case presentation  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Fundamento: el linfoma es la proliferación monoclonal neoplásica de células linfoides en localizaciones del sistema inmunitario, que incluyen ganglios linfáticos, médula ósea, bazo, hígado y tracto gastrointestinal. Caso Clínico: se presentó el caso de Linfoma no Hodgkin linfoblástico de alto grado [...] de malignidad, en una paciente de 36 años de edad con antecedentes de hepatitis viral, giardiasis y aborto provocado con implantación de dispositivo intrauterino, que ingresa en el servicio de terapia intensiva del Hospital Universitario Manuel Ascunce Domenech por ausencia de apetito, decaimiento y pérdida de peso de 30 libras aproximadamente en tres meses; en la exploración física inicial se encuentran grandes edemas blandos en miembros inferiores y caquexia, además de distensión abdominal. Después de una estadía prolongada y tórpida evolución, la paciente fallece. Abstract in english Background: lymphoma is the proliferation of neoplastic monoclonal of lymphoid cells in locations of the immune system, including lymph nodes, bone marrow, spleen, liver and gastrointestinal tract. Clinical case: is presented a case of a lymphoblastic non-Hodgkin´s lymphoma´s of high-grade of malign [...] ancy in a 36-year-old patient with a history of viral hepatitis, giardiasis and abortion caused by implantation of intra-uterine device, admitted in the intensive care unit service at Manuel Ascunce Domenech University Hospital by lack of appetite, dwindles, weight loss of 30 pounds approximately in three months, and in the initial physical examination are found large soft edema in lower limbs and cachexia and abdominal distention. After a long stay and torpid evolution, the patient died.

Manuel M, Basulto Barroso; Zaily, Fuentes Díaz; María del Carmen, Galdós Sánchez; Raúl A, Pérez Sarmiento; René, Rabasa Pérez.

314

Tratado hispano-mapuche de Negrete de 1803  

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Full Text Available Se exponen las circunstancias que rodearon la firma de un tratado en el parlamento que tuvo lugar en los días 3 a 5 de marzo de 1803, en que por la parte española actuó don Pedro Quijada, comandante general de la región del río Bío-Bío en representación del gobernador Luis Muñoz de Guzmán, y por la parte indígena un número de doscientos treinta y nueve caciques principales. Se presentan las cláusulas más importantes del tratado.This article describes the circumstances surrounding the signature of the Treaty in Parliament, which took place on March 3-5, 1803, when don Pedro Quijada, commander in chief to the River Bío-Bío Region, acted as representative of Governor Luis Muñoz Guzmán on behalf of the Spanish party, and two hundred and thirty-nine chief caciques acted on behalf of the indigenous party. The most important clauses of the treaty are presented.

Abelardo Levaggi

2004-01-01

315

Comparison of external and intravascular cooling to induce hypothermia in patients after CPR  

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Full Text Available Objective: Hypothermia has been shown to reduce neurologic deficits in patients after cardiopulmonary resuscitation (CPR. It was not clear if intravascular cooling is superior to standard external cooling in inducing hypothermia. Goal of this study was to compare intravascular cooling with an automated cooling device with external cooling in everyday practice on a cardiac-care ICU (intensive care unit. Methods: Patients after successful CPR for unwitnessed cardiac arrest were subjected to cooling with an automated cooling system (CoolGard, Alsius after initial hemodynamic stabilization. Goal was to achieve a core temperature of 33°C. Monitored were the time intervals from admission to begin of cooling and from begin of cooling to target temperature. Data were compared retrospectively with those from patients subjected to external cooling. Results: 31 consecutive patients treated with intravascular cooling were analyzed. Cooling was initiated at a mean time of 58 min after admission, and the target temperature of 33°C was achieved after a mean of 3.48 hours after the begin of cooling. In contrast, 49 patients treated with external cooling achieved a minimum temperature of 34.8°C only 9.2 hours after admission. Conclusion: In everyday practice, intravascular cooling using an automated cooling system is superior for a rapid induction of hypothermia after cardiac arrest.

Strasser, Ruth H.

2006-06-01

316

Low-level He-Ne laser in intravascular irradiation treatment of schizophrenia  

Science.gov (United States)

Intravascular low level He-Ne laser irradiation is a new therapy developed in recent years. In our hospital it was applied in the treatment and observation of 220 cases of schizophrenia, among which certain effect was achieved and about which the detail was collated and elaborated.

Zhou, Yu-Xue; Fu, Zheng-Hua

1998-11-01

317

Lung and renal uptake of techneticum Tc 99m sulphur colloid related to disseminated intravascular coagulation  

Energy Technology Data Exchange (ETDEWEB)

In addition to a recently published case study, we present another three cases in which we observed both lung and renal uptake of technetium Tc 99m sulphur colloid which was related to a period of disseminated intravascular coagulation. Being familiar with this relationship may influence the diagnosis and course of the illness in certain patients.

Jelle Teertstra, H.; Verdegaal, W.P.; Ras, G.J.

1985-01-01

318

MANAGEMENT OF DISSEMINATED INTRAVASCULAR COAGULATION BY AGGRESSIVE COMPONENT THERAPY: A CASE REPORT  

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Disseminated intravascular coagulation is a life threatening complication of severe postpartum hemorrhage. It results from washing out of all important procoagulants. A case of hemorrhagic shock following atonic postpartum hemorrhage is reported. She was treated by emergency obstetric hysterectomy and aggressive blood and blood component therapy.

Bangal, V.; Kwatra A; Gulati P

2010-01-01

319

MANAGEMENT OF DISSEMINATED INTRAVASCULAR COAGULATION BY AGGRESSIVE COMPONENT THERAPY: A CASE REPORT  

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Full Text Available Disseminated intravascular coagulation is a life threatening complication of severe postpartum hemorrhage. It results from washing out of all important procoagulants. A case of hemorrhagic shock following atonic postpartum hemorrhage is reported. She was treated by emergency obstetric hysterectomy and aggressive blood and blood component therapy.

V. Bangal

2010-03-01

320

Avaliação morfológica e imuno-histoquímica de linfomas gástricos primários / Morphologic and immunohistochemical evaluation of primary gastric lymphomas  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese INTRODUÇÃO: Os linfomas gástricos primários representam cerca de 50% dos linfomas não-Hodgkin extranodais e de 2% a 8% das neoplasias malignas do estômago. A maioria é formada pela proliferação de linfócitos B, que ocorre a partir do tecido linfóide associado à mucosa. Esse tecido, inexistente no es [...] tômago em condições normais, surge como conseqüência de gastrite crônica, na maioria das vezes associada à bactéria Helicobacter pylori. A inflamação crônica provocada pela infecção bacteriana parece sensibilizar linfócitos T, levando a estímulo constante de linfócitos B, que passam a proliferar inicialmente em padrão reacional. Posteriormente surgem alterações genômicas nessas células, que provocam ganho proliferativo, seleção clonal e transformação neoplásica, dando origem a linfoma de baixo grau. Alterações genéticas adicionais, como mutações em p53, podem induzir transformação para alto grau. MATERIAL E MÉTODOS: Foram estudados 32 casos de linfomas gástricos: 15 de baixo e 17 de alto grau. Foram investigados sexo e idade dos pacientes, características morfológicas das lesões,índice de proliferação celular e colonização pelo Helicobacter pylori. Verificou-se a expressão de CD20, Ki-67, p53, BCL-2 e BCL-6 por imuno-histoquímica. RESULTADOS: Os linfomas gástricos ocorreram mais freqüentemente em homens, e a faixa etária mais elevada foi observada no grupo de baixo grau. Lesões linfoepiteliais foram observadas em 93% dos linfomas desse grupo. O índice de proliferação celular e a expressão do p53 foram mais elevados no grupo de alto grau. A expressão do BCL-2 foi mais elevada nos linfomas de baixo grau. Não houve diferença significante quanto à expressão do BCL-6 nos dois grupos. CONCLUSÃO: Os resultados sugerem a participação dos genes p53 e BCL-2 na patogênese e na evolução dos linfomas gástricos. Abstract in english INTRODUCTION: Primary gastric lymphomas account for 50% of the extranodal non-Hodgkin lymphoma and for 2% to 8% of the malignant gastric neoplasms. Most of them arise from B lymphocytes proliferation of the mucosaassociated lymphoid tissue. This tissue is not present in stomach in normal conditions; [...] it arises secondarily to chronic gastritis, frequently associated to the bacterium Helicobacter pylori. Chronic inflammation of the bacterium infection seems to induce T lymphocytes, leading to persistent stimulation of B lymphocytes that initially proliferate in a reactive fashion. After that, there are some genomic changes in the lymphoid cells, including BCL-2 and BCL-6 mutation inducing some proliferating gain, clonal selection and neoplastic transformation, originating the lowgrade gastric lymphoma. Additional genetic changes, like p53 mutation, can induce high-grade transformation. MATERIAL AND METHODS: We revised 32 cases of gastric lymphomas: 15 low and 17 high-grade. The age and the gender of those patients were investigated. The morphological characteristics of the lesions and Helicobacter pylori colonization were assessed. Immunohistochemistry to CD20, Ki-67, p53, BCL-2 and BCL-6 was performed. RESULTS: Gastric lymphomas occur more frequently in males and patients' age is more advanced in the low grade group. Lymphoepithelial lesions were observed in 93% of this lymphoma group. The proliferative rate and p53 expression were greater in the high grade group. The BCL-2 expression was higher in the low grade lymphoma group. There were no significant differences in BCL-6 expression in both groups. CONCLUSION: The results suggest that genes P53 and BCL-2 play a role in the pathogenesis and evolution of gastric lymphomas.

Jorge Alberto, Thomé; Agnes Cristina, Fett-Conte; José Antonio, Cordeiro.

 
 
 
 
321

El Tratado de Lisboa (Un juego de espejos rotos  

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Full Text Available El fracaso del Tratado por el que se establece una Constitución para Europa produjo un periodo de incertidumbre y perplejidad del que ha costado mucho sobreponerse. Por un momento, todo parecía resquebrajarse y se tuvo la sensación de que la imagen de unidad en la diversidad, que con tanta dificultad se había forjado, se partía hecha añicoscomo un espejo roto. No obstante, como en un “juego de espejos rotos”, el ideal europeísta se ha ido recomponiendo con un gran esfuerzo, dando lugar a un texto, el Tratado de Lisboa, que encierra una solución de compromiso con el fin de saldar la crisis cuando el futuro de la Unión Europea parecía oscurecerse. Como en los poemas de Alejandra Pizarnik, “cuando el palacio de la noche encierra su hermosura, pulsaremos los espejos hasta que nuestros rostros canten como ídolos” y, así fue como con un esfuerzo milimetrado se ha ido recomponiendo este rompecabezas de cristales con el fin de que en él se refleje, otra vez, la ansiada imagen global. Como se señala enPreámbulo del Tratado de Lisboa, deberemos estar resueltos a salvar una nueva etapa en proceso de integración europea y habrá que recordar “la importancia histórica de que la división del continente europeo haya tocado a su fin y la necesidad de sentar unas bases firmes para la construcción de la futura Europa”.

Juan Manuel de Faramiñán Gilbert

2009-01-01

322

ENFERMEDAD RENAL POLIQUISTICA ASOCIADA A LINFOMA EXTRANODAL EN UN CANINO / RENAL POLICYST DISEASE ASSOCIATED TO LYMPHOMA EXTRANODAL IN A CANINE  

Scientific Electronic Library Online (English)

Full Text Available SciELO Colombia | Language: Spanish Abstract in spanish Objetivo: Presentar el caso de un paciente canino, con enfermedad renal poliquística, asociada a linfoma extranodal. Materiales y métodos: Se estudió el caso de un paciente canino de raza Siberian Husky de 7 años de edad, al que se le encontraron múltiples nódulos renales bilaterales, con diagnóstic [...] o histopatológico de linfoma extranodal. Resultados: Se expone el caso clínico de un paciente canino de raza Siberian Husky, que es presentado a consulta dermatológica por exhibir lesiones alopécicas multifocales. Una vez realizado el examen físico sistemático se evidenció de manera incidental nefromegalia. Los exámenes paraclínicos e histopatológicos aplicados demostraron la presencia de enfermedad renal poliquística asociada a linfoma extranodal, como consecuencia se presento falla renal crónica. Conclusiones: El linfoma extranodal renal es una entidad patológica de rara presentación, clínicamente cursa con signos muy similares a otras alteraciones tumorales, su diagnóstico suele ser histopatológico. Abstract in english Objective: To present the case of a canine patient, with renal policyst disease, associated to extranodal lymphoma. Materials and methods: The case of a canine patient Siberian Husky, of 7 years old was studied to which multiple bilateral renal nodules were found, with histopathological diagnostic o [...] f extranodal lymphoma. Results: The clinical case of a canine patient of race Siberian Husky is exposed and presented to dermatological consultation to exhibit alopecia multifocal lesions. Once made the systematic physical exam was evidenced nephromegaly in incidental way. The paraclinical and applied histopathological exams demonstrated the presence of renal policyst disease associated to extranodal lymphoma, as consequence renal chronicle alteration was presented. Conclusions: The renal extranodal lymphoma is a pathological entity of strange presentation, clinically frequent with very similar signs to other tumoral alterations, its diagnosis is usually histopathological.

Diego, Echeverry B; Ximena, Barbosa S; Edwin, Buriticá G.

323

Linfoma de células fusiformes: relato anatomopatológico de um caso com apresentação pulmonar / Spindle cell lymphoma: a case with pulmonary presentation  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese São raros os linfomas que se apresentam com padrão histológico de células fusiformes. Relatamos um caso de tumor pulmonar isolado em homem de 74 anos, diagnosticado em biópsia de agulha como neoplasia maligna de células fusiformes. Na ocasião, o estudo imuno-histoquímico favoreceu pseudotumor inflam [...] atório. Sete meses após, o paciente foi laparotomizado devido a tumor perfurado intestinal. Os estudos anatomopatológico e imuno-histoquímico estabeleceram o diagnóstico de linfoma B difuso de grandes células. A revisão do tumor pulmonar revelou positividade franca para CD45 e CD20, confirmando o diagnóstico de Linfoma B de células fusiformes. Esta publicação visa a alertar para essa incomum apresentação dos linfomas, que necessita ser considerada, no diagnóstico diferencial de neoplasias de células fusiformes. Abstract in english This paper reports a rare malignant lymphoma with histological spindle-cell pattern. Seventy four year-old man presented with lung tumor. A diagnostic of spindle-cell malignant neoplasia was made and immunohistochemical studies were suggestive of inflammatory pseudotumor. Three months later, the pat [...] ient returned to our service with acute abdomen. The surgery showed small Intestinal perforation associated with tumor. Microscopic examination and immunohistochemical studies revealed Diffuse B-large cell lymphoma. After the diagnostic of the intestinal tumor, the lung tumor was reviewed, showing positivity for CD45 and CD20 antibodies. This result supports the diagnostic of Spindle B-cell lymphoma, in the lung tumor. The aim of this report is to alert pathologists about this rare spindle cell pattern presentation of lymphomas, that must be differentiated from true sarcomas and others spindle-cell neoplasias.

Túlio Geraldo de Souza e, Souza; Luciana de Oliveira, Leandro; Maria Betânia Souza da, Silva; Venâncio Avancini Ferreira, Alves; Celso Rubens Vieira e, Silva.

324

Linfoma de células fusiformes: relato anatomopatológico de um caso com apresentação pulmonar Spindle cell lymphoma: a case with pulmonary presentation  

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Full Text Available São raros os linfomas que se apresentam com padrão histológico de células fusiformes. Relatamos um caso de tumor pulmonar isolado em homem de 74 anos, diagnosticado em biópsia de agulha como neoplasia maligna de células fusiformes. Na ocasião, o estudo imuno-histoquímico favoreceu pseudotumor inflamatório. Sete meses após, o paciente foi laparotomizado devido a tumor perfurado intestinal. Os estudos anatomopatológico e imuno-histoquímico estabeleceram o diagnóstico de linfoma B difuso de grandes células. A revisão do tumor pulmonar revelou positividade franca para CD45 e CD20, confirmando o diagnóstico de Linfoma B de células fusiformes. Esta publicação visa a alertar para essa incomum apresentação dos linfomas, que necessita ser considerada, no diagnóstico diferencial de neoplasias de células fusiformes.This paper reports a rare malignant lymphoma with histological spindle-cell pattern. Seventy four year-old man presented with lung tumor. A diagnostic of spindle-cell malignant neoplasia was made and immunohistochemical studies were suggestive of inflammatory pseudotumor. Three months later, the patient returned to our service with acute abdomen. The surgery showed small Intestinal perforation associated with tumor. Microscopic examination and immunohistochemical studies revealed Diffuse B-large cell lymphoma. After the diagnostic of the intestinal tumor, the lung tumor was reviewed, showing positivity for CD45 and CD20 antibodies. This result supports the diagnostic of Spindle B-cell lymphoma, in the lung tumor. The aim of this report is to alert pathologists about this rare spindle cell pattern presentation of lymphomas, that must be differentiated from true sarcomas and others spindle-cell neoplasias.

Túlio Geraldo de Souza e Souza

2006-02-01

325

Primary liver AIDS-related lympoma / Linfoma não-Hodgkin primário do fígado em paciente com SIDA  

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Full Text Available SciELO Brazil | Language: English Abstract in portuguese Os linfomas não-Hodgkin (LNH) são as segundas neoplasias mais freqüentes nos pacientes com síndrome da imunodeficiência adquirida (SIDA). A maioria dos LNH associados à AIDS envolvem locais extra-ganglionares, especialmente o trato digestivo e o sistema nervoso central. O linfoma não-Hodgkin primári [...] o do fígado (LPF) é uma neoplasia incomum nestes pacientes. A ultrassonografia (US) e a tomografia computadorizada (TC) podem ser úteis no diagnóstico de linfoma não-Hodgkin hepático apresentando-se como lesões multifocais. A biópsia com agulha fina guiada por imagens (US, TC) juntamente com a histopatologia das lesões do fígado constitui o padrão-ouro para o diagnóstico de linfoma hepático. Este trabalho relata um caso de LPF como manifestação inicial de AIDS em um paciente sem infecção prévia pelo vírus da hepatite C e B, que se apresentou como massas hepáticas múltiplas e de grandes dimensões. Abstract in english Non-Hodgkin's lymphomas (NHL) are the second most frequent malignancies in AIDS patients. The majority of NHL associated with AIDS involves extranodal sites, especially the digestive tract and the central nervous system. Primary liver lymphoma (PLL) is an uncommon neoplasm among these patients. Ultr [...] asonography and computed tomography scans may be helpful in the diagnosis of focal hepatic lymphoma. Image-guided fine-needle biopsy with histopathology of the liver lesions is the gold standard for the diagnosis of hepatic lymphoma. We report a case of PLL as the initial manifestation of AIDS in a patient without any previous infection by hepatitis C or B virus, presented as multiple and large hepatic masses.

María Florencia, Villafañe; Norberto, Trione; Marcelo, Corti; Nora, Mendez; Elisa, Gancedo; Norberto, Zamora; Marta, Levin.

326

Primary liver AIDS-related lympoma Linfoma não-Hodgkin primário do fígado em paciente com SIDA  

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Full Text Available Non-Hodgkin's lymphomas (NHL are the second most frequent malignancies in AIDS patients. The majority of NHL associated with AIDS involves extranodal sites, especially the digestive tract and the central nervous system. Primary liver lymphoma (PLL is an uncommon neoplasm among these patients. Ultrasonography and computed tomography scans may be helpful in the diagnosis of focal hepatic lymphoma. Image-guided fine-needle biopsy with histopathology of the liver lesions is the gold standard for the diagnosis of hepatic lymphoma. We report a case of PLL as the initial manifestation of AIDS in a patient without any previous infection by hepatitis C or B virus, presented as multiple and large hepatic masses.Os linfomas não-Hodgkin (LNH são as segundas neoplasias mais freqüentes nos pacientes com síndrome da imunodeficiência adquirida (SIDA. A maioria dos LNH associados à AIDS envolvem locais extra-ganglionares, especialmente o trato digestivo e o sistema nervoso central. O linfoma não-Hodgkin primário do fígado (LPF é uma neoplasia incomum nestes pacientes. A ultrassonografia (US e a tomografia computadorizada (TC podem ser úteis no diagnóstico de linfoma não-Hodgkin hepático apresentando-se como lesões multifocais. A biópsia com agulha fina guiada por imagens (US, TC juntamente com a histopatologia das lesões do fígado constitui o padrão-ouro para o diagnóstico de linfoma hepático. Este trabalho relata um caso de LPF como manifestação inicial de AIDS em um paciente sem infecção prévia pelo vírus da hepatite C e B, que se apresentou como massas hepáticas múltiplas e de grandes dimensões.

María Florencia Villafañe

2006-08-01

327

Linfoma não-Hodgkin em tireóide: relato de caso Non-Hodgkin's lymphoma in the thyroid: case report  

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Os autores relatam o caso de uma paciente do sexo feminino, 33 anos de idade, branca, sem evidência clínico-laboratorial de tireoidite ou hipotireoidismo clínico, que apresentou uma massa cervical de crescimento rápido. Através de exames histopatológico e imuno-histoquímico, foi realizado o diagnóstico de linfoma não-Hodgkin folicular em tireóide.The authors describe the case of a 33 year-old white female, without any clinical or laboratorial evidence of thyroiditis or clinical ...

Evandro de Azambuja; Sérgio Jobim de Azevedo; Roger Moreira; Leite Castro, Rodrigo C.

2004-01-01

328

Manifestações de linfoma na síndrome de Sjögren: existe relação? Lymphoma's manifestations in Sjögren's syndrome: is there a relation?  

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A Síndrome de Sjögren (SS) é considerada uma afecção multissistêmica, crônica, que se caracteriza pela infiltração linfocítica nas glândulas exócrinas e a produção de auto-anticorpos. OBJETIVO: Vários estudos têm notado um aumento na incidência de linfomas malignos em pacientes com SS. Em nosso estudo tentamos descrever esta relação. FORMA DE ESTUDO: Coorte transversal. MATERIAL E MÉTODO: Pacientes com Síndrome Sicca acompanhados no ambulatório de Estomatologia do Depart...

Fabrícia Dias Colombano Limares; Rita De Cássia Soler; Ivo Bussoloti Filho

2005-01-01

329

Non Hodgkin T cell lymphoma: an atypical clinical presentation / Linfoma não Hodgkin de células T citotóxico: uma apresentação clínica atípica  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese Os linfomas citotóxicos compreendem um espectro de linfomas de células T periféricos e linfomas Natural Killer que podem ter expressão cutânea primária ou secundária. Descrevemos o caso de um homem com 46 anos de idade, natural de Cabo Verde,com dermatose envolvendo a face e tronco constituída por p [...] ápulas monomorfas superfície lisa e polineuropatia sensitivo motora.A hipótese de Hanseníase foi colocada suportada por achados histopatológicos sugestivos sendo o doente referenciado à consulta de Doença de Hansen do nosso hospital. Em biopsia de pele e de gânglio identificou-se proliferação linfocitária cujo estudo imunohistoquímico permitiu o diagnóstico de linfoma T com expressão de marcadores citotóxicos. Iniciou quimioterapia verificando-se inicialmente remissão parcial das lesões cutâneas mas posteriormente a progressão da doença sistémica. Abstract in english Cytotoxic lymphomas comprise a spectrum of peripheral T-cell lymphomas that can have a initial or late cutaneous presentation. We describe a 46-year-old man from Cape Verde, with a dermatosis involving his face and trunk, consisting of monomorphic papules with a smooth surface and both motor and sen [...] sory polyneuropathy.The hypothesis of leprosy was supported by the clinical and initial hystopathological findings and the patient was referred to our hospital with suspected Hansen's disease. In the new skin and lymph node biopsies a lymphocyte population was identified whose immunohystochemistry study allowed the diagnosis of T-cell lymphoma with expression of cytotoxic markers. The patient was started on chemotherapy with initial remission of the skin lesions but, subsequently, progression of systemic disease.

Paula, Maio; Diogo, Bento; Raquel, Vieira; Ana, Afonso; Fernanda, Sachse; Heinz, Kutzner.

330

Linfoma Linfocítico, bien diferenciado de la próstata: Presentación de un caso y breve revisión de la literatura / Well-differentiated lymphocytic lymphoma of the prostate: Case report and bibliographic review  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish Objetivo: Presentar un caso portador de un linfoma de próstata, en un paciente de 70 años de edad y hacer una breve revisión de la literatura. Método/resultados: Se trata de un paciente varón de 70 años de edad, que es visto en consulta de Urología por presentar un cuadro de prostatismo, llegando a [...] la retención aguda de orina (RAO). Es intervenido quirúrgicamente realizándosele una prostatectomía retropúbica, obteniéndose como resultado anatomopatológico un linfoma primario de próstata, el paciente fue remitido a Oncología, siendo tratado con radioterapia, llevando actualmente seguimiento en consulta de Urología. Se hace una breve revisión bibliográfica, donde analizamos las manifestaciones clínicas de esta entidad, las pruebas complementarias que nos ayudan a hacer el diagnóstico (exámenes de laboratorio, biopsia prostática transrectal, resección transuretral, ecografía, tomografía axial computarizada), los tratamientos que se aplican (cirugía, radioterapia, poliquimioterapia) así como la supervivencia de estos pacientes. Conclusiones: La edad promedio de diagnóstico en la casuística revisada por nosotros fue de 57 años. La forma clínica de debut son síntomas de prostatismo, pudiendo estar presente la RAO y en algunos casos manifestaciones de insuficiencia renal por uropatía obstructiva, así como manifestaciones generales (astenia, anorexia, pérdida de peso). Las cifras de antígeno específico prostático (PSA) no sufren alteraciones en los linfomas prostáticos. El diagnóstico histológico se puede realizar a través de la biopsia de próstata transrectal, aunque puede ser necesario la resección transuretral (RTU) de próstata para una mejor confirmación. La ultrasonografía y la tomografía axial computarizada (TAC) son de gran utilidad para el diagnóstico tanto local como de extensión de estos tumores. Desde el punto de vista del tratamiento puede ser necesario la cirugía desobstructiva (RTU, prostatectomía a cielo abierto), asociación con corticoides y otros citostáticos, la radioterapia y también se ha utilizado la quimioterapia intratecal, el transplante autólogo de médula ósea como complemento. Abstract in english Objective: To report a case of prostate lymphoma and a brief review of the literature. Methods/results: A 70 year-old mele patient was referred to the Urology departament with a clinical picture of prostatism, with acute urinary retention (AUR). Surgery with retropubic prostatectomy was performed, a [...] nd pathology revealed a primary prostate lymphoma. The patient was referred to the departament of Oncology where he received polychemotherapy and radiotherapy. The patient is currently followed by regular visits to Urology outpatients service.The case study is followed by a brief bibliographic review, where we analyse clinical menifestations of this entity, complementary studies useful for diagnosis (laboratory test, trasrectal prostate biopsy, transuretral resection, ultrasound and computerised axial tomography), treatment options (surgery, polychemotherapy, radiotherapy) as well as survival in these patients. Conclusions: Of the cases reviewed, mean age at diagnosis was 57 years. Clinical debut was with prostate symptoms, with or without AUR and sometimes manifestations of renal f