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Sample records for control analysis mca

  1. Development of the Taiwanese Mandarin Main Concept Analysis (TM-MCA: Normative and Preliminary Aphasic Data

    Anthony Pak Hin Kong

    2014-03-01

    Full Text Available Introduction Compared to the English literature, there is a great paucity of studies focusing on quantitative analysis of aphasic oral discourse in Chinese, especially for native speakers of Taiwanese-Mandarin residing in Taiwan. Several studies that investigated deficits of aphasic discourse have been conducted in Cantonese Chinese, including the Cantonese Linguistic Communication Measure (CLCM, Kong & Law, 2004, Main Concept Analysis (MCA; Kong, 2009, and Cantonese version of the Quantitative Production Analysis (Law, 2001; Yiu & Worrall, 1996. Clinical or research application of these systems to the Taiwanese population is limited by the differences of phonology, semantics, and grammar between Taiwanese Mandarin and Cantonese. The current study, therefore, aimed to develop a culturally appropriate Taiwan Mandarin Main Concept Analysis (TM-MCA, by translating and adapting the MCA in Cantonese (Kong, 2009, 2011, and then to validate the tool on the basis of normal speakers and people with aphasia in Taiwan. Method Picture stimuli and main concepts for the TM-MCA: Eight certified Taiwanese SLPs participated and listed all main concepts upon presentation of the sequential pictures in Kong (2009. A main concept referred to a statement consisting of only one main verb with two or more pieces of essential information accurately related to the pictures and informative about the content. All main concepts mentioned by six out of eight SLPs were included in a preliminary main concept list. Further validation of the list involved recruiting eight normal speakers to orally describe the same picture sets. Only those scored as Accurate and Complete (AC or Accurate but Incomplete (AI by at least five speakers were put in the final list. Normative and aphasic data collection and analysis: Thirty six native Taiwanese Mandarin speakers and ten individuals with aphasia orally perform the same picture description tasks. Six measures, including Number of Accurate

  2. A Taiwanese Mandarin Main Concept Analysis (TM-MCA) for Quantification of Aphasic Oral Discourse

    Kong, Anthony Pak-Hin; Yeh, Chun-Chih

    2015-01-01

    Background: Various quantitative systems have been proposed to examine aphasic oral narratives in English. A clinical tool for assessing discourse produced by Cantonese-speaking persons with aphasia (PWA), namely Main Concept Analysis (MCA), was developed recently for quantifying the presence, accuracy and completeness of a narrative. Similar…

  3. Use of multiple correspondence analysis (MCA) to identify interactive meteorological conditions affecting relative throughfall

    Van Stan, John T.; Gay, Trent E.; Lewis, Elliott S.

    2016-02-01

    Forest canopies alter rainfall reaching the surface by redistributing it as throughfall. Throughfall supplies water and nutrients to a variety of ecohydrological components (soil microbial communities, stream water discharge/chemistry, and stormflow pathways) and is controlled by canopy structural interactions with meteorological conditions across temporal scales. This work introduces and applies multiple correspondence analyses (MCAs) to a range of meteorological thresholds (median intensity, median absolute deviation (MAD) of intensity, median wind-driven droplet inclination angle, and MAD of wind speed) for an example throughfall problem: identification of interacting storm conditions corresponding to temporal concentration in relative throughfall beyond the median observation (⩾73% of rain). MCA results from the example show that equalling or exceeding rain intensity thresholds (median and MAD) corresponded with temporal concentration of relative throughfall across all storms. Under these intensity conditions, two wind mechanisms produced significant correspondences: (1) high, steady wind-driven droplet inclination angles increased surface wetting; and (2) sporadic winds shook entrained droplets from surfaces. A discussion is provided showing that these example MCA findings agree well with previous work relying on more historically common methods (e.g., multiple regression and analytical models). Meteorological threshold correspondences to temporal concentration of relative throughfall at our site may be a function of heavy Tillandsia usneoides coverage. Applications of MCA within other forests may provide useful insights to how temporal throughfall dynamics are affected for drainage pathways dependent on different structures (leaves, twigs, branches, etc.).

  4. Performance analysis of gamma ray spectrometric parameters on digital signal and analog signal processing based MCA systems using NaI(Tl) detector

    Kukreti, B.M., E-mail: bharatkuk@gmail.com [Atomic Minerals Directorate for Exploration and Research, Physics Laboratory, Department of Atomic Energy, Nongmynsong, AMD Complex, Shillong, Meghalaya 793019 (India); Sharma, G.K. [Atomic Minerals Directorate for Exploration and Research, Physics Laboratory, Department of Atomic Energy, Nongmynsong, AMD Complex, Shillong, Meghalaya 793019 (India)

    2012-05-15

    Accurate and speedy estimations of ppm range uranium and thorium in the geological and rock samples are most useful towards ongoing uranium investigations and identification of favorable radioactive zones in the exploration field areas. In this study with the existing 5 in. Multiplication-Sign 4 in. NaI(Tl) detector setup, prevailing background and time constraints, an enhanced geometrical setup has been worked out to improve the minimum detection limits for primordial radioelements K{sup 40}, U{sup 238} and Th{sup 232}. This geometrical setup has been integrated with the newly introduced, digital signal processing based MCA system for the routine spectrometric analysis of low concentration rock samples. Stability performance, during the long counting hours, for digital signal processing MCA system and its predecessor NIM bin based MCA system has been monitored, using the concept of statistical process control. Monitored results, over a time span of few months, have been quantified in terms of spectrometer's parameters such as Compton striping constants and Channel sensitivities, used for evaluating primordial radio element concentrations (K{sup 40}, U{sup 238} and Th{sup 232}) in geological samples. Results indicate stable dMCA performance, with a tendency of higher relative variance, about mean, particularly for Compton stripping constants. - Highlights: Black-Right-Pointing-Pointer Geometrical enhancement for ppm range primordial radio elemental determination. Black-Right-Pointing-Pointer Experimental constraints include detector setup, background and counting time. Black-Right-Pointing-Pointer Gamma spectrometric performance monitored on digital and analog MCA systems. Black-Right-Pointing-Pointer Study indicates higher variance of Compton stripping constants on digital MCA system.

  5. Project evaluation, sustainability and accountability: combining cost-benefit analysis (CBA) and multi-criteria analysis (MCA)

    Sijtsma, F.J.

    2006-01-01

    General abstract Decision-makers in governments and businesses must choose among different project alternatives which, in varying degrees, contribute to sustainability. Decision-makers also have to account for their choices to a large audience or a broad range of stakeholders. This thesis is about the positive and negative aspects of using the main judgement-oriented evaluation tools of Cost-Benefit Analysis (CBA) and Multi Criteria Analysis (MCA) together in the context of sustainability and...

  6. Development of 8K-MCA Add-on based on FPGA technique with a control of VB6 software application under windows environment

    The multichannel analyzer is the heart of most experimental measurements. Today, it becomes popular and convenient. It can play a role of getting, processing data and easily interfacing to PC. Some standard-alone multichannel analysis systems can be replaced by Add-on MCA card. Especially, MCA card is necessary for application in nuclear physics research. The main aim of this sub-project is to focus on a design and construction of an 8K-MCA Add-on served for studying nuclear structure, for development of Gamma spectroscopy system, and for a production of low-cost electronics instruments as well. Some experimental results were obtained through the aforementioned card combining with other needed functional analog units. A multichannel data processing (MCD) circuit for nuclear spectroscopy application was developed using a field programmable gate arrays (FPGA) as the central processing element. In addition to the first role, A 13-bit analog-to-digital converter (8k ADC) circuit for nuclear spectroscopy application was also developed using a successive approximation ADC with a control of FPGA technology. The FPGA operates a program that builds the distributed functions of data collected by the ADC and then corrects the ADC differential non-linearity (DNL) via the sliding scale method. The acquisition routine runs in 3.7μ s. the conversion time is approximated 2.2μ s, and the integral non-linearity ≤ 0.14%. (author)

  7. Dual function of the McaS small RNA in controlling biofilm formation

    Jørgensen, Mikkel Girke; Thomason, Maureen K.; Havelund, Johannes;

    2013-01-01

    S activates synthesis of the exopolysaccharide beta-1,6 N-acetyl-D-glucosamine (PGA) by binding the global RNA-binding protein CsrA, a negative regulator of pgaA translation. The McaS RNA bears at least two CsrA-binding sequences, and inactivation of these sites compromises CsrA binding, PGA regulation, and......Many bacterial small RNAs (sRNAs) regulate gene expression through base-pairing with mRNAs, and it has been assumed that these sRNAs act solely by this one mechanism. Here we report that the multicellular adhesive (McaS) sRNA of Escherichia coli uniquely acts by two different mechanisms: base......-pairing and protein titration. Previous work established that McaS base pairs with the mRNAs encoding master transcription regulators of curli and flagella synthesis, respectively, resulting in down-regulation and up-regulation of these important cell surface structures. In this study, we demonstrate that Mca...

  8. The use of multi-criteria analysis (MCA) for evaluating feasible countermeasures after an accidental release of radioactivity

    The aim of this study is to establish a system that enables rational decisions to be taken for reducing (if necessary) the radiological risk to a population. These decisions normally concern whether a particular food product will be consumed or not, as well as wether it should be diverted for other uses. To evaluate the consequences of such actions, many different criteria have to be taken into account such as the radiological risk, nutritional and environmental criteria, current technical intervention levels, economic costs and public reaction. Under the guidance of the Institute of Automation and Operations Research at the University of Fribourg a Multi-Criteria-Analysis (MCA) approach, based on the most recent developments in decision theory, is being elaborated. MCA requires input from a suite of sub-models combined with basic input data. For the radiological impact model the German code ECOSYS will be adapted for Swiss conditions. Furthermore, input data on the effect of food processing on radionuclide content of foodstuffs and consumption habits are needed. MCA thus allows the consequences of different countermeasures to be assessed in relation to the different governing criteria. In order to allow efficient use of this technique it shall be implemented as a user friendly computerized decision support system. In this paper, an example of different countermeasures to reduce the dose from milk contaminated with I-131 resulting from a reactor accident is given

  9. System of accounting and control of nuclear materials (MCA) relative to IAEA safeguards and improvement of radioecological situation of the Joint Stock Company ULBA Metallurgical Plant

    Following goals must be accomplished following this Project : - Develop computerized and automated MCA data system; - Provide up-to-date and reliable accounting and control of availability and transfer of nuclear materials, detect loss or theft of nuclear materials; - Improve book keeping of nuclear materials, provide paperwork for raw materials and finished products sales and purchase control, process nuclear materials shipment data; - Reduce sampling error and to obtain precise measure of nuclear materials to obtain ESADRA target values; - Thorium concentrates transfer preliminary released from raw Beryllium to the new storage to prevent environment radiation pollution and obvious fire accidents; - Improve radioecological situation of the territory caused by old storage dismantling and decontamination of site; - Improve accounting, storing and Physical Protection of Thorium Following is the proposal to obtain goals of the Project : - Develop accounting and control systems - Develop basic standards and procedures for MCA system - Develop users specifications of MCA data system - Develop software of MCA data system - Assembly and adjustment of local network at the production facilities - Automated MCA data system personnel training - Develop measurement system - Determination of the mistakes in sampling and measurement of Uranium and isotopes content - Develop the procedures of sampling and measurement of Uranium and isotopes content providing ESADRA target values - Develop measure control program covering scales and analytical equipment and measuring methods - Develop software for measure control program support - Thorium shipment, decontamination and improvement of Physical Protection of Thorium storage - Accounting of Thorium containing materials when transferring to the new storage - Arrange storage decontamination - Develop new systems of Thorium Containment/Surveillance and Physical Protection

  10. Rapid and accurate identification of isolates of Candida species by melting peak and melting curve analysis of the internally transcribed spacer region 2 fragment (ITS2-MCA)

    Decat, E.; van Mechelen, E.; Saerens, B.; Vermeulen, S.J.T.; Boekhout, T.; de Blaiser, S.; Vaneechoutte, M.; Deschaght, P.

    2013-01-01

    Rapid identification of clinically important yeasts can facilitate the initiation of anti-fungal therapy, since susceptibility is largely species-dependent. We evaluated melting peak and melting curve analysis of the internally transcribed spacer region 2 fragment (ITS2-MCA) as an identification too

  11. The hardware design of digital MCA based on FPGA and USB

    An digital MCA (multi-channel analyzer) based on FPGA and USB2.0 technology is introduced. FPGA is the main processor. The nuclear signal through the amplifier circuit and AD converter is processed in FPGA. then the result is transferred to host computer through USB2.0 interface. The design achieves full digital control. Verilog HDL is used for FPGA programming and the interface software on the host computer is written in QT. The software on the host computer accomplishes the acquisition and display of the input signal and the MCA spectrum. The MCA pulse-amplitude analysis is achieved digitally in FPGA. (authors)

  12. Investigating changes in brain network properties in HIV-associated neurocognitive disease (HAND) using mutual connectivity analysis (MCA)

    Abidin, Anas Zainul; D'Souza, Adora M.; Nagarajan, Mahesh B.; Wismüller, Axel

    2016-03-01

    About 50% of subjects infected with HIV present deficits in cognitive domains, which are known collectively as HIV associated neurocognitive disorder (HAND). The underlying synaptodendritic damage can be captured using resting state functional MRI, as has been demonstrated by a few earlier studies. Such damage may induce topological changes of brain connectivity networks. We test this hypothesis by capturing the functional interdependence of 90 brain network nodes using a Mutual Connectivity Analysis (MCA) framework with non-linear time series modeling based on Generalized Radial Basis function (GRBF) neural networks. The network nodes are selected based on the regions defined in the Automated Anatomic Labeling (AAL) atlas. Each node is represented by the average time series of the voxels of that region. The resulting networks are then characterized using graph-theoretic measures that quantify various network topology properties at a global as well as at a local level. We tested for differences in these properties in network graphs obtained for 10 subjects (6 male and 4 female, 5 HIV+ and 5 HIV-). Global network properties captured some differences between these subject cohorts, though significant differences were seen only with the clustering coefficient measure. Local network properties, such as local efficiency and the degree of connections, captured significant differences in regions of the frontal lobe, precentral and cingulate cortex amongst a few others. These results suggest that our method can be used to effectively capture differences occurring in brain network connectivity properties revealed by resting-state functional MRI in neurological disease states, such as HAND.

  13. Assessment of Cerebrovascular Reserve before and after STA-MCA Bypass Surgery by SPECT and SPM Analysis

    The purpose of this study was to objectively assess the efficacy of superficial temporal artery to middle cerebral artery (STA-MCA) bypass surgery using Technetium (Tc)-99m-ethyl cysteinate dimer (ECD) single photon emission computed tomography (SPECT) in patients who underwent STA-MCA bypass surgery. Brain perfusion SPECT images obtained at baseline and after the administration of acetazolamide were reconstructed using statistical parametric mapping in 23 patients, both before and after STA-MCA bypass surgery. The clinical outcomes of the surgery were also recorded and compared with the hemodynamic changes. A voxel with an uncorrected p-value of less than 0.001 was considered to be statistically significant. SPECT images of the territory supplied by the bypass graft showed an increase in both cerebrovascular flow and reserve at baseline, and the increase was significantly higher following the administration of acetazolamide. All patients showed improvement of clinical symptoms and increased blood flow to the left temporal, parietal, and frontal cortices as well as the thalamus. Brain SPECT effectively and objectively demonstrated the improved outcomes of STA-MCA bypass surgery, and thus may be used in postoperative analyses

  14. Mutual connectivity analysis (MCA) using generalized radial basis function neural networks for nonlinear functional connectivity network recovery in resting-state functional MRI

    D'Souza, Adora M.; Abidin, Anas Zainul; Nagarajan, Mahesh B.; Wismüller, Axel

    2016-03-01

    We investigate the applicability of a computational framework, called mutual connectivity analysis (MCA), for directed functional connectivity analysis in both synthetic and resting-state functional MRI data. This framework comprises of first evaluating non-linear cross-predictability between every pair of time series prior to recovering the underlying network structure using community detection algorithms. We obtain the non-linear cross-prediction score between time series using Generalized Radial Basis Functions (GRBF) neural networks. These cross-prediction scores characterize the underlying functionally connected networks within the resting brain, which can be extracted using non-metric clustering approaches, such as the Louvain method. We first test our approach on synthetic models with known directional influence and network structure. Our method is able to capture the directional relationships between time series (with an area under the ROC curve = 0.92 +/- 0.037) as well as the underlying network structure (Rand index = 0.87 +/- 0.063) with high accuracy. Furthermore, we test this method for network recovery on resting-state fMRI data, where results are compared to the motor cortex network recovered from a motor stimulation sequence, resulting in a strong agreement between the two (Dice coefficient = 0.45). We conclude that our MCA approach is effective in analyzing non-linear directed functional connectivity and in revealing underlying functional network structure in complex systems.

  15. Evaluation of effectiveness for MC&A programs

    Wilkey, D. D. (David Dennis); DeMuth, S. F. (Scott F.); Longmire, V. L. (Victoria L.); Sinkule, B. J. (Barbara J.); Strittmatter, R. B. (Richard B.); Stevens, R. S. (Rebecca S.); Dawson, P. (Pamela); Preston, L. (Lynne)

    2004-01-01

    This paper is a progress report on a joint Los Alamos and Sandia National Laboratories effort to develop tools to evaluate MC&A system effectiveness and perform vulnerability assessments based on the system effectiveness metrics. It summarizes the work that the two labs have completed to date and provides an overview of the work remaining. The Department of Energy Office of Technology Development, SO-20.3, is presently considering whether it is possible to model MC&A programs at DOE facilities in order to better determine the need for and prioritize potential technology development projects. The intent is to develop an objective method of evaluating MC&A programs, to model the effect of changes to the systems used by the programs, and to quantify the extent to which these changes improve the effectiveness and efficiency of the programs. Project milestones include a review of the risk analysis tool developed at Sandia, ATLAS, to determine how MC&A system elements could be incorporated, identification of MC&A system elements and activities for which effectiveness metrics can be developed, and developing the metrics for these system elements. In addition, the milestones include validation of the system elements and effectiveness metrics by potential users. Upon completion of the development of MC&A system effectiveness metrics, we will determine the feasibility of integrating the data elements and process required for evaluation of MC&A effectiveness metrics into ATLAS.

  16. A Study of MCA Learning Algorithm for Incident Signals Estimation

    Rashid Ahmed

    2014-12-01

    Full Text Available Many signal subspace-based approaches have already been proposed for determining the fixed Direction of Arrival (DOA of plane waves impinging on an array of sensors. Two procedures for DOA estimation based neural network are presented. Firstly, Principal Component Analysis (PCA is employed to extract the maximum eigenvalue and eigenvector from signal subspace to estimate DOA. Secondly, Minor component analysis (MCA is a statistical method of extracting the eigenvector associated with the smallest eigenvalue of the covariance matrix. In this paper, we will modify a MCA learning algorithm to enhance the Convergence, where a Convergence is essential for MCA algorithm towards practical applications. The learning rate parameter is also presented, which ensures fast convergence of the algorithm, because it has direct effect on the convergence of the weight vector and the error level is affected by this value. MCA is performed to determine the estimated DOA. Simulation results will be furnished to illustrate the theoretical results achieved.

  17. Improved MCA-TV algorithm for interference hyperspectral image decomposition

    Wen, Jia; Zhao, Junsuo; Cailing, Wang

    2015-12-01

    The technology of interference hyperspectral imaging, which can get the spectral and spatial information of the observed targets, is a very powerful technology in the field of remote sensing. Due to the special imaging principle, there are many position-fixed interference fringes in each frame of the interference hyperspectral image (IHI) data. This characteristic will affect the result of compressed sensing theory and traditional compression algorithms used on IHI data. According to this characteristic of the IHI data, morphological component analysis (MCA) is adopted to separate the interference fringes layers and the background layers of the LSMIS (Large Spatially Modulated Interference Spectral Image) data, and an improved MCA and Total Variation (TV) combined algorithm is proposed in this paper. An update mode of the threshold in traditional MCA is proposed, and the traditional TV algorithm is also improved according to the unidirectional characteristic of the interference fringes in IHI data. The experimental results prove that the proposed improved MCA-TV (IMT) algorithm can get better results than the traditional MCA, and also can meet the convergence conditions much faster than the traditional MCA.

  18. Mini-MCA: an intelligent inspection instrument

    The small portable multichannel analyzer (Mini-MCA) designed at Los Alamos National Laboratory is an intelligent safeguards instrument developed for the IAEA under the United States Aid Program. The Mini-MCA is a basic 1-k channel MCA that features a high degree of user friendliness and portability. Its history, use, and future applications are discussed. 5 figures, 3 tables

  19. Metabolic control analysis of xylose catabolism in Aspergillus

    Prathumpai, W.; Gabelgaard, J.B.; Wanchanthuek, P.; Vondervoort, van de P.J.I.; Groot, de M.J.L.; McIntyre, M.; Nielsen, J.

    2003-01-01

    A kinetic model for xylose catabolism in Aspergillus is proposed. From a thermodynamic analysis it was found that the intermediate xylitol will accumulate during xylose catabolism. Use of the kinetic model allowed metabolic control analysis (MCA) of the xylose catabolic pathway to be carried out, an

  20. Structural characterization of the mechanosensitive channel candidate MCA2 from Arabidopsis thaliana.

    Hideki Shigematsu

    Full Text Available Mechanosensing in plants is thought to be governed by sensory complexes containing a Ca²⁺-permeable, mechanosensitive channel. The plasma membrane protein MCA1 and its paralog MCA2 from Arabidopsis thaliana are involved in mechanical stress-induced Ca²⁺ influx and are thus considered as candidates for such channels or their regulators. Both MCA1 and MCA2 were functionally expressed in Sf9 cells using a baculovirus system in order to elucidate their molecular natures. Because of the abundance of protein in these cells, MCA2 was chosen for purification. Purified MCA2 in a detergent-solubilized state formed a tetramer, which was confirmed by chemical cross-linking. Single-particle analysis of cryo-electron microscope images was performed to depict the overall shape of the purified protein. The three-dimensional structure of MCA2 was reconstructed at a resolution of 26 Å from 5,500 particles and appears to comprise a small transmembrane region and large cytoplasmic region.

  1. The development of a portable MCA

    The paper describes the Multichannel Analyzer (MCA) based on digital peak searching technology. The peak-searching function is implemented in the complex programmable logic devices (CPLD) and is designed using the hardware description language which is quite flexible and convenient. After completion of peak searching, the MCU takes the responsibility of data acquisition, and management. The data are transported to the host computer by the USB port. Compared with the traditional MCA, our design has advantages such as small size, low power consumption, easy to operate and so on. (authors)

  2. Band-to-band registration and ortho-rectification of multilens/multispectral imagery: A case study of MiniMCA-12 acquired by a fixed-wing UAS

    Jhan, Jyun-Ping; Rau, Jiann-Yeou; Huang, Cho-Ying

    2016-04-01

    MiniMCA (Miniature Multiple Camera Array) is a lightweight, frame-based, and multilens composed multispectral sensor, which is suitable to mount on an unmanned aerial systems (UAS) to acquire high spatial and temporal resolution imagery for various remote sensing applications. Since MiniMCA has significant band misregistration effect, an automatic and precise band-to-band registration (BBR) method is proposed in this study. Based on the principle of sensor plane-to-plane projection, a modified projective transformation (MPT) model is developed. It is to estimate all coefficients of MPT from indoor camera calibration, together with two systematic errors correction. Therefore, we can transfer all bands into the same image space. Quantitative error analysis shows that the proposed BBR scheme is scene independent and can achieve 0.33 pixels of accuracy, which demonstrating the proposed method is accurate and reliable. Meanwhile, it is difficult to mark ground control points (GCPs) on the MiniMCA images, as its spatial resolution is low when the flight height is higher than 400 m. In this study, a higher resolution RGB camera is adopted to produce digital surface model (DSM) and assist MiniMCA ortho-image generation. After precise BBR, only one reference band of MiniMCA image is necessary for aerial triangulation because all bands have same exterior and interior orientation parameters. It means that all the MiniMCA imagery can be ortho-rectified through the same exterior and interior orientation parameters of the reference band. The result of the proposed ortho-rectification procedure shows the co-registration errors between MiniMCA reference band and the RGB ortho-images is less than 0.6 pixels.

  3. Improved MCA programmed by LabVIEW language

    PC based Multichannel analyser (MCA) is a popular instrument in the nuclear physics experiment. The authors introduce one kind of improved MCA which is programmed by LabVIEW language. This MCA has many advantages such as powerful data processing capability, more friendly interface and is easy to use. The basic principle of this MCA and the core technology of its software are described. Some results of experiment are presented too

  4. [A Case of ECA-MCA Double Anastomoses for Hemorrhagic Type of Twig-Like MCA].

    Inoue, Akihiro; Kohno, Kanehisa; Fukumoto, Shinya; Ichikawa, Haruhisa; Onoue, Shinji; Miyazaki, Hajime; Ozaki, Saya; Iwata, Shinji

    2016-06-01

    Herein, we describe the case of a superficial temporal artery(STA)- and occipital artery(OA)-middle cerebral artery(MCA)double anastomoses that we performed to treat a hemorrhagic twig-like MCA. A 55-year-old man presented to our hospital for investigation of an incidentally identified left MCA occlusion. Left cerebral angiography revealed a twig-like MCA. The 123I-IMP-single photon emission computed tomography(SPECT)demonstrated no reduction in the cerebral blood flow(CBF), so the patient was initially observed with no treatment. Three months later, he was readmitted with a disturbance of consciousness. The cranial computed tomography revealed a subcortical hemorrhage in the left frontotemporal region and a subdural hematoma. The hematoma was removed via emergency craniotomy. The abnormal vessels were identified and resected, but the parietal branch of the STA was damaged during the skin incision. The histological examination did not reveal the marked fibrous thickening of the intima or wavy internal elastic lamina typically seen with Moyamoya disease. Six months after the initial surgery, a STA-MCA bypass surgery was planned to prevent a future hemorrhage by reducing the hemodynamic overload of the twig-like MCA and improving the cerebral ischemia in the MCA territory that was detected on the preoperative SPECT. However, the parietal branch of the left STA had been injured during the first operation, so we performed a double anastomoses to the MCA using the frontal branch of the STA and the OA. The patient's postoperative course was uneventful and he was discharged 2 weeks after surgery. The follow-up study performed 1 year postoperatively demonstrated no evidence of cerebral infarction and revealed an improvement in the resting CBF and vascular reactivity in the left cerebral hemisphere. No subsequent cerebrovascular events have occurred in this patient during the 7 years since the double anastomoses surgery. Direct bypass for flow conversion from the internal

  5. Metabolic Control Analysis: A Tool for Designing Strategies to Manipulate Metabolic Pathways

    Emma Saavedra

    2008-07-01

    Full Text Available The traditional experimental approaches used for changing the flux or the concentration of a particular metabolite of a metabolic pathway have been mostly based on the inhibition or over-expression of the presumed rate-limiting step. However, the attempts to manipulate a metabolic pathway by following such approach have proved to be unsuccessful. Metabolic Control Analysis (MCA establishes how to determine, quantitatively, the degree of control that a given enzyme exerts on flux and on the concentration of metabolites, thus substituting the intuitive, qualitative concept of rate limiting step. Moreover, MCA helps to understand (i the underlying mechanisms by which a given enzyme exerts high or low control and (ii why the control of the pathway is shared by several pathway enzymes and transporters. By applying MCA it is possible to identify the steps that should be modified to achieve a successful alteration of flux or metabolite concentration in pathways of biotechnological (e.g., large scale metabolite production or clinical relevance (e.g., drug therapy. The different MCA experimental approaches developed for the determination of the flux-control distribution in several pathways are described. Full understanding of the pathway properties when working under a variety of conditions can help to attain a successful manipulation of flux and metabolite concentration.

  6. Evaluating and prioritizing technologies for adaptation to climate change. A hands on guidance to multi criteria analysis (MCA) and the identification and assessment of related criteria

    Trærup, Sara Lærke Meltofte; Bakkegaard, Riyong Kim

    2015-01-01

    The objective of this guidance is to guide consultants, decision makers and technical experts on how to facilitate discussions for prioritizing adaptation technologies, and to support the stakeholders in identifying appropriate criteria for this analysis.

  7. Evaluating and prioritizing technologies for adaptation to climate change. A hands on guidance to multi criteria analysis (MCA) and the identification and assessment of related criteria

    Trærup, Sara Lærke Meltofte; Bakkegaard, Riyong Kim

    The objective of this guidance is to guide consultants, decision makers and technical experts on how to facilitate discussions for prioritizing adaptation technologies, and to support the stakeholders in identifying appropriate criteria for this analysis.......The objective of this guidance is to guide consultants, decision makers and technical experts on how to facilitate discussions for prioritizing adaptation technologies, and to support the stakeholders in identifying appropriate criteria for this analysis....

  8. A Simulation of Energy Storage System for Improving the Power System Stability with Grid-Connected PV using MCA Analysis and LabVIEW Tool

    Jindrich Stuchly

    2015-01-01

    Full Text Available The large-scale penetration of distributed, Renewable power plants require transfers of large amounts of energy. This, in turn, puts a high strain on the energy delivery infrastructure. In particular, photovoltaic power plants supply energy with high intermittency, possibly affecting the stability of the grid by changing the voltage at the plant connection point. In this contribution, we summarize the main negative effects of selected and real-operated grid connected photovoltaic plant. Thereafter a review of suitable Energy storage systems to mitigate the negative effects has been carried out, compared and evaluated using Multi-criterion analysis. Based on this analysis, data collected at the plant and the grid, are used to design the energy storage systems to support connection of the plant to the grid. The cooperation of these systems is then analysed and evaluated using simulation tools created in LabVIEW for this purpose. The simulation results demonstrate the capability of energy storage system solutions to significantly reduce the negative feedback effects of Photovoltaic Power Plan to the low voltage grid.

  9. Cortical Reorganization of Language Functioning Following Perinatal Left MCA Stroke

    Tillema, Jan-Mendelt; Byars, Anna W.; Jacola, Lisa M.; Schapiro, Mark B.; Schmithorst, Vince J.; Szaflarski, Jerzy P.; Holland, Scott K.

    2008-01-01

    Objective: Functional MRI was used to determine differences in patterns of cortical activation between children who suffered perinatal left middle cerebral artery (MCA) stroke and healthy children performing a silent verb generation task. Methods: Ten children with prior perinatal left MCA stroke (age 6-16 years) and ten healthy age matched…

  10. Linear analysis near a steady-state of biochemical networks: control analysis, correlation metrics and circuit theory

    Qian Hong

    2008-05-01

    Full Text Available Abstract Background: Several approaches, including metabolic control analysis (MCA, flux balance analysis (FBA, correlation metric construction (CMC, and biochemical circuit theory (BCT, have been developed for the quantitative analysis of complex biochemical networks. Here, we present a comprehensive theory of linear analysis for nonequilibrium steady-state (NESS biochemical reaction networks that unites these disparate approaches in a common mathematical framework and thermodynamic basis. Results: In this theory a number of relationships between key matrices are introduced: the matrix A obtained in the standard, linear-dynamic-stability analysis of the steady-state can be decomposed as A = SRT where R and S are directly related to the elasticity-coefficient matrix for the fluxes and chemical potentials in MCA, respectively; the control-coefficients for the fluxes and chemical potentials can be written in terms of RT BS and ST BS respectively where matrix B is the inverse of A; the matrix S is precisely the stoichiometric matrix in FBA; and the matrix eAt plays a central role in CMC. Conclusion: One key finding that emerges from this analysis is that the well-known summation theorems in MCA take different forms depending on whether metabolic steady-state is maintained by flux injection or concentration clamping. We demonstrate that if rate-limiting steps exist in a biochemical pathway, they are the steps with smallest biochemical conductances and largest flux control-coefficients. We hypothesize that biochemical networks for cellular signaling have a different strategy for minimizing energy waste and being efficient than do biochemical networks for biosynthesis. We also discuss the intimate relationship between MCA and biochemical systems analysis (BSA.

  11. MCA Vmean and the arterial lactate-to-pyruvate ratio correlate during rhythmic handgrip

    Rasmussen, Peter; Plomgaard, Peter; Krogh-Madsen, Rikke; Kim, Yu-Sok; van Lieshout, Johannes J; Secher, Niels H; Quistorff, Bjørn

    2006-01-01

    Regulation of cerebral blood flow during physiological activation including exercise remains unknown but may be related to the arterial lactate-to-pyruvate (L/P) ratio. We evaluated whether an exercise-induced increase in middle cerebral artery mean velocity (MCA Vmean) relates to the arterial L....../P ratio at two plasma lactate levels. MCA Vmean was determined by ultrasound Doppler sonography at rest, during 10 min of rhythmic handgrip exercise at approximately 65% of maximal voluntary contraction force, and during 20 min of recovery in seven healthy male volunteers during control and a.......0) with a corresponding MCA Vmean of 46.7 +/- 4.5 cm/s. During rhythmic handgrip the increase in MCA Vmean to 51.2 +/- 4.6 cm/s was related to the increased L/P ratio (23.8 +/- 2.5; r2 = 0.79; P < 0.01). Hyperglycemia increased arterial lactate and pyruvate to 1.9 +/- 0.2 mmol/l and 115 +/- 4 micromol...

  12. The metacaspase (Mca1p) has a dual role in farnesol-induced apoptosis in Candida albicans.

    Léger, Thibaut; Garcia, Camille; Ounissi, Marwa; Lelandais, Gaëlle; Camadro, Jean-Michel

    2015-01-01

    Manipulating the apoptotic response of Candida albicans may help in the control of this opportunistic pathogen. The metacaspase Mca1p has been described as a key protease for apoptosis in C. albicans but little is known about its cleavage specificity and substrates. We therefore initiated a series of studies to describe its function. We used a strain disrupted for the MCA1 gene (mca1Δ/Δ) and compared its proteome to that of a wild-type isogenic strain, in the presence and absence of a known inducer of apoptosis, the quorum-sensing molecule farnesol. Label-free and TMT labeling quantitative proteomic analyses showed that both mca1 disruption and farnesol treatment significantly affected the proteome of the cells. The combination of both conditions led to an unexpected biological response: the strong overexpression of proteins implicated in the general stress. We studied sites cleaved by Mca1p using native peptidomic techniques, and a bottom-up approach involving GluC endoprotease: there appeared to be a "K/R" substrate specificity in P1 and a "D/E" specificity in P2. We also found 77 potential substrates of Mca1p, 13 of which validated using the most stringent filters, implicated in protein folding, protein aggregate resolubilization, glycolysis, and a number of mitochondrial functions. An immunoblot assay confirmed the cleavage of Ssb1p, a member of the HSP70 family of heat-shock proteins, in conditions where the metacaspase is activated. These various results indicate that Mca1p is involved in a limited and specific proteolysis program triggered by apoptosis. One of the main functions of Mca1p appears to be the degradation of several major heat-shock proteins, thereby contributing to weakening cellular defenses and amplifying the cell death process. Finally, Mca1p appears to contribute significantly to the control of mitochondria biogenesis and degradation. Consequently, Mca1p may be a link between the extrinsic and the intrinsic programmed cell death pathways

  13. Metabolic control analysis of xylose catabolism in Aspergillus

    Prathumpai, Wai; Gabelgaard, J.B.; Wanchanthuek, P.; van de Vondervoort, P.J.I.; de Groot, M.J.L.; Mcintyre, Mhairi; Nielsen, Jens

    2003-01-01

    A kinetic model for xylose catabolism in Aspergillus is proposed. From a thermodynamic analysis it was found that the intermediate xylitol will accumulate during xylose catabolism. Use of the kinetic model allowed metabolic control analysis (MCA) of the xylose catabolic pathway to be carried out......, and flux control was shown to be dependent on the metabolite levels. Due to thermodynamic constraints, flux control may reside at the first step in the pathway, i.e., at the xylose reductase, even when the intracellular xylitol concentration is high. On the basis of the kinetic analysis, the general...... dogma specifying that flux control often resides at the step following an intermediate present at high concentrations was, therefore, shown not to hold. The intracellular xylitol concentration was measured in batch cultivations of two different strains of Aspergillus niger and two different strains of...

  14. Status of Activities to Implement a Sustainable System of MC&A Equipment and Methodological Support at Rosatom Facilities

    J.D. Sanders

    2010-07-01

    Under the U.S.-Russian Material Protection, Control and Accounting (MPC&A) Program, the Material Control and Accounting Measurements (MCAM) Project has supported a joint U.S.-Russian effort to coordinate improvements of the Russian MC&A measurement system. These efforts have resulted in the development of a MC&A Equipment and Methodological Support (MEMS) Strategic Plan (SP), developed by the Russian MEM Working Group. The MEMS SP covers implementation of MC&A measurement equipment, as well as the development, attestation and implementation of measurement methodologies and reference materials at the facility and industry levels. This paper provides an overview of the activities conducted under the MEMS SP, as well as a status on current efforts to develop reference materials, implement destructive and nondestructive assay measurement methodologies, and implement sample exchange, scrap and holdup measurement programs across Russian nuclear facilities.

  15. 32 CFR 644.417 - For MCA family housing.

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true For MCA family housing. 644.417 Section 644.417... family housing. The Act of 1 September 1954, Pub. L. 765, 83rd Congress (68 Stat. 1119), as amended by... Construction-Army Family Housing at Military Installations and Facilities.”...

  16. Comparative study of Energy Dispersive X-ray Spectrum Deconvolution: PyMCA and WinAxil

    A comparative study of spectrum deconvolution and quantitative analysis between PyMCA & WinAxil has been undertaken. Standard spectra of X-ray Kα lines (Ti, Fe, Co, Ni, Cu, Zn, As, Sr & Y) & Lα lines (Ce, Sm, Dy, Ta, W, Hg & U) were fitted with both software; also spectra of three soil samples were fitted with both software. Intensities of the elements of the standard spectra were obtained from the results of the fitting using both software and comparisons were made separately for both Kα & Lα lines between the two software. Sensitivity calibrations were done for both Kα & Lα lines and comparisons between the two software were also made. The intensities of the spectra of the three soil samples obtained from fitting using both software were also compared. Quantitative analysis of the spectra of the three soil samples was performed and the concentrations of the elements obtained using both software were compared. A simple manual for spectrum fitting and quantitative analysis using PyMCA has been written for first-time users of the software (PyMCA); a flowchart for the manual has also been prepared. Comparison of intensities for Kα elements showed excellent agreement between the two software. The intensities of Lα elements obtained also compared favourably. Comparison of the concentrations of the elements in the spectra of the three soil samples showed excellent agreement. The X-ray spectrum fitting capabilities of PyMCA compare favourably with those of WinAxil. The development of WinAxil has been discontinued; therefore, PyMCA when appropriately adapted can be used in place of WinAxil for qualitative and quantitative analysis for spectra from X-ray tube excitation sources. (au)

  17. MCA Based Performance Evaluation of Project Selection

    Bakshi, Tuli

    2011-01-01

    Multi-criteria decision support systems are used in various fields of human activities. In every alternative multi-criteria decision making problem can be represented by a set of properties or constraints. The properties can be qualitative & quantitative. For measurement of these properties, there are different unit, as well as there are different optimization techniques. Depending upon the desired goal, the normalization aims for obtaining reference scales of values of these properties. This paper deals with a new additive ratio assessment method. In order to make the appropriate decision and to make a proper comparison among the available alternatives Analytic Hierarchy Process (AHP) and ARAS have been used. The uses of AHP is for analysis the structure of the project selection problem and to assign the weights of the properties and the ARAS method is used to obtain the final ranking and select the best one among the projects. To illustrate the above mention methods survey data on the expansion of optic...

  18. Estimating the robustness of composite CBA & MCA assessments by variation of criteria importance order

    Jensen, Anders Vestergaard; Barfod, Michael Bruhn; Leleur, Steen

    , the proposed method uses surrogate weights based on rankings of the criteria, by the use of Rank Order Distribution (ROD) weights [3]. This reduces the problem to assigning a rank order value for each criterion. A method for combining the MCA with the cost-benefit analysis (CBA) is applied as...... the outcome of the method is a subset of the total solution space. The paper finishes up with a discussion and considerations about how to present the results. The question whether to present a single decision criterion, such as the benefit-cost rate or the net present value, or instead to present...

  19. MCA Based Performance Evaluation of Project Selection

    Tuli Bakshi

    2011-04-01

    Full Text Available Multi-criteria decision support systems are used in various fields of human activities. In every alternativemulti-criteria decision making problem can be represented by a set of properties or constraints. Theproperties can be qualitative & quantitative. For measurement of these properties, there are differentunit, as well as there are different optimization techniques. Depending upon the desired goal, thenormalization aims for obtaining reference scales of values of these properties. This paper deals with anew additive ratio assessment method. In order to make the appropriate decision and to make a propercomparison among the available alternatives Analytic Hierarchy Process (AHP and ARAS have beenused. The uses of AHP is for analysis the structure of the project selection problem and to assign theweights of the properties and the ARAS method is used to obtain the final ranking and select the best oneamong the projects. To illustrate the above mention methods survey data on the expansion of optical fibrefor a telecommunication sector is used. The decision maker can also used different weight combination inthe decision making process according to the demand of the system.

  20. A 256 channel portable MCA for field application [Paper No.:I3

    In-situ gamma-spectrometry is a very important tool to characterise the contamination resulting due to radioactive fall out. Even in reactor environment this technique is helpful in analysing contaminations and the leakages on the spot. A battery powered 256 channel portable pulse height analyser has been developed to meet this requirement. The analyser consists of a single card Wilkinson type 8 bit ADC cum linear amplifier interfaced to an 8085 based micro computer. The MCA uses 2x2 inch NaI(Tl) detector and provides minimal necessary front panel controls for field use. A built-in DC to DC converter generates EHT for detector system and all the necessary DC voltages (+5V, ± 12V) from a 6V (7AH) battery. The MCA is capable of storing around 60 spectrums sequentially which can be down-loaded into a PC for further processing through built in serial RS-232 port. The paper describes the hardware and software developed for the system, and its performance evaluations. (author). 3 figs

  1. Interactive Controls Analysis (INCA)

    Bauer, Frank H.

    1989-01-01

    Version 3.12 of INCA provides user-friendly environment for design and analysis of linear control systems. System configuration and parameters easily adjusted, enabling INCA user to create compensation networks and perform sensitivity analysis in convenient manner. Full complement of graphical routines makes output easy to understand. Written in Pascal and FORTRAN.

  2. MCaVoH: A toolkit for mining, classification and visualization of human microbiota.

    Nisar, Maryum; Noureen, Nighat; Fazal, Sahar; Qadir, Muhammad Abdul

    2015-10-01

    Human body is the home for a large number of microbes. The complexity of enterotype depends on the body site. Microbial communities in various samples from different regions are being classified on the basis of 16S rRNA gene sequences. With the improvement in sequencing technologies various computational methods have been used for the analysis of microbiome data. Despite several available machine learning techniques there is no single platform available which could provide several techniques for clustering, multiclass classification, comparative analysis and the most significantly the identification of the subgroups present within larger groups of human microbial communities. We present a tool named MCaVoH for this purpose which performs clustering and classification of 16S rRNA sequence data and highlight various groups. Our tool has an added facility of biclustering which produces local group of communities present within larger groups (clusters). The core objective of our work was to identify the interaction between various bacterial species along with monitoring the composition and variations in microbial communities. MCaVoH also evaluates the performance and efficiency of different techniques using comparative analysis. The results are visualized through different plots and graphs. We implemented our tool in MATLAB. We tested our tool on several real and simulated 16S rRNA data sets and it outperforms several existing methods. Our tool provides a single platform for using multiple clustering, classification algorithms, local community identification along with their comparison which has not been done so far. Tool is available at https://sourceforge.net/projects/mcavoh/. PMID:26193336

  3. Collapse of the western North America climate dipole during the MCA and LIA

    Asmerom, Y.; Polyak, V. J.; Rasmussen, J.; Burns, S. J.; Lachniet, M. S.

    2011-12-01

    Understanding of the teleconnections between regional climate regimes and the time-scale of the stability of these teleconnections is crucial for building predictive models of climate change. Using annually-resolved speleothem physical (band thickness, hiatus and mineralogy) and oxygen and carbon isotopic effective moisture proxy data, we show climate variability in the southwestern United States (SW) during the critical Medieval Climate Anomaly and Little Ice Age (LIA) intervals. Although the MCA overall was not markedly drier than the wet latter half of the LIA, it was punctuated by multiple megadroughts. The driest interval was the early LIA, during which we identify an extended multi-century drought, which we will refer to as a Super Drought (SD), occurring during the early LIA ca. AD 1350 to AD 1650. There is a well-established dipole response to Pacific Decadal Oscillation (PDO) and El Nino-Southern Oscillation (ENSO) variability between the SW and northwestern United States (NW), and the SW and the Asian monsoon during the modern and overall Holocene climate regime. Our data indicate that this climate dipole apparently collapsed during the MCA-LIA, extending back to about 300 AD, such that pluvial and drought intervals in the SW and NW, and SW and Asian monsoon occur contemporaneously over this period. The modern positive relationship between moisture and the PDO observed in the SW is also reversed. During this interval the PDO is negatively correlated with SW moisture amount. In addition, the strong solar control of Holocene climate observed previously in western North America and the Asian monsoon is weakened during parts of this interval, such that solar maxima and minima do not correlate coherently with precipitation variability both in North America and the Asian monsoon. The MCA-early LIA period in which the megadroughts dominate occurs within the prominently positive phase of the North Atlantic Oscillation (NAO). One potential mechanism of propagating

  4. J-ACT II. Differences in rate of valid recanalization and of a favorable outcome by site of MCA occlusion

    The background and purpose of this study was to elucidate whether the effects of alteplase differ with occlusion site of the middle cerebral artery (MCA). An exploratory analysis was made of 57 patients enrolled on the Japan Alteplase Clinical Trial II (J-ACT II). The residual vessel length (mm), determined on pretreatment MR angiography (MRA), was used to reflect the occluded site. The proportions of patients with valid recanalization (modified Mori grade 2-3) at 6 and 24 hours, and a favorable outcome (modified Rankin scale 0-1 at 3 months) were compared between the groups dichotomized according to their lengths of residual vessel. Multiple logistic regression models were generated to elucidate the predictors of valid recanalization and a favorable outcome. Receiver operating characteristic (ROC) analysis revealed that 5 mm was the practical cutoff length for the dichotomization. In patients with M1 length <5 mm (n=12), the frequencies of valid recanalization at 6/24 hours (16.6%/25.0%) were significantly low compared with those (62.2%/82.2%) of 45 patients with a residual M1 length of ≥5 mm and M2 occlusions (p=0.008 for 6 hours, p<0.001 for 24 hours). The proportion of a favorable outcome was also small in patients with M1 length <5 mm (8.3%), as compared to the others (57.8%, p=0.004). In logistic regression models, the site of MCA occlusion (<5 mm) was the significant predictor of valid recanalization at 6/24 hours and of a favorable outcome. In patients with acute MCA occlusion, residual vessel length <5 mm on MRA can identify poor responders. (author)

  5. INCA- INTERACTIVE CONTROLS ANALYSIS

    Bauer, F. H.

    1994-01-01

    The Interactive Controls Analysis (INCA) program was developed to provide a user friendly environment for the design and analysis of linear control systems, primarily feedback control systems. INCA is designed for use with both small and large order systems. Using the interactive graphics capability, the INCA user can quickly plot a root locus, frequency response, or time response of either a continuous time system or a sampled data system. The system configuration and parameters can be easily changed, allowing the INCA user to design compensation networks and perform sensitivity analysis in a very convenient manner. A journal file capability is included. This stores an entire sequence of commands, generated during an INCA session into a file which can be accessed later. Also included in INCA are a context-sensitive help library, a screen editor, and plot windows. INCA is robust to VAX-specific overflow problems. The transfer function is the basic unit of INCA. Transfer functions are automatically saved and are available to the INCA user at any time. A powerful, user friendly transfer function manipulation and editing capability is built into the INCA program. The user can do all transfer function manipulations and plotting without leaving INCA, although provisions are made to input transfer functions from data files. By using a small set of commands, the user may compute and edit transfer functions, and then examine these functions by using the ROOT_LOCUS, FREQUENCY_RESPONSE, and TIME_RESPONSE capabilities. Basic input data, including gains, are handled as single-input single-output transfer functions. These functions can be developed using the function editor or by using FORTRAN- like arithmetic expressions. In addition to the arithmetic functions, special functions are available to 1) compute step, ramp, and sinusoid functions, 2) compute closed loop transfer functions, 3) convert from S plane to Z plane with optional advanced Z transform, and 4) convert from Z

  6. Hydrographic changes in the subpolar North Atlantic at the MCA to LIA transition

    Divine, Dmitry; Miettinen, Arto; Husum, Katrine; Koc, Nalan

    2016-04-01

    A network of four marine sediment cores from the northern North Atlantic is used to study hydrographic changes in surface water masses during the last 2000 years with a special focus on the Medieval Climate Anomaly (MCA) to the Little Ice Age (LIA) transition. Three of the cores are recovered from the sites located on main pathways of warm Atlantic water to the Arctic: M95-2011 (Vøring plateau, Norwegian Sea), Rapid-21 COM and LO-14 (Reykjanes Ridge, south of Iceland). The fourth core MD99-2322 is from the SE Greenland shelf (Denmark Strait), and it is influenced by the cold water outflow from the Arctic. The cores were analyzed continuously for planktonic diatoms with a high decadal to subdecadal temporal resolution. Past changes in the spatial distribution of surface water masses have been studied identifying factors, or typical species compositions, in downcore diatom assemblages. To derive the factors a Q-mode factor analysis has been applied to the extended modern calibration data set of 184 surface sediment samples from the North Atlantic, the Labrador Sea, the Nordic Seas, and Baffin Bay. SSTs have also been reconstructed using transfer functions. Variations of the reconstructed SSTs and loadings of major contributing factors reveal a complex regional pattern of changes in the structure of circulation during the MCA/LIA transition (1200-1400 AD). In the Norwegian Sea, the factors associated with assemblages typical for warmer and saline North Atlantic waters are partly displaced by colder and fresher water dwelling diatoms suggesting an eastward migration of mixed Arctic/Atlantic water masses into the Norwegian Sea. The two cores south of Iceland show a westward propagation of a warm water pulse as evidenced by the dominance of assemblages, which today are typical for the waters ca 5° further south than the current study sites. At the SE Greenland shelf an abrupt shift (ca. 50 years) in factors associated with different sea ice zone dwelling diatoms

  7. Process analysis and optimal control

    The presented publication should considered to be an introduction into some problems of process analysis and optimal control with respect to complex systems. An essential aspect of the work is to present this matter with the view of using microcomputers. The publication contains chapters on some mathematical and theoretical terms, real time regime, process analysis, optimal control, and control of complex systems. (author)

  8. Construction of a reasonable multi channel analyzer (MCA) with an educational FPGA board

    In resent years, the performances of new electronic devices, for example FPGA or so on, have been improved, and these devices become more cost-effective ones year by year. Moreover, prices of personal computers have become less expensive, and the programming environment on PC becomes much user-friendly and easy to operate in this decimal year. These advancements have possibilities to provide a great help for self-constructions of radiation measurement equipments, which needed huge cost and work to construct in the past. Then, I tried to construct a reasonable Mulch Channel Analyzer (MCA) with an educational FPGA board named EDX-005 (HuMANDATA ltd.), and conduct test measurements of the MCA. The MCA was constructed in a short period, and its cost was just under 50 thousands yen. The MCA normally works at 200 [cps/ch] count rate with a NaI(Tl) scintillation counter. The description of the MCA and some points of self-constructions of radiation measurement equipments are provided in this paper. (author)

  9. Dual Phases of Respiration Chain Defect-Augmented mROS-Mediated mCa2+ Stress during Oxidative Insult in Normal and ρ0 RBA1 Astrocytes

    Tsung-I Peng

    2013-01-01

    Full Text Available Mitochondrial respiratory chain (RC deficits, resulting in augmented mitochondrial ROS (mROS generation, underlie pathogenesis of astrocytes. However, mtDNA-depleted cells (ρ0 lacking RC have been reported to be either sensitive or resistant to apoptosis. In this study, we sought to determine the effects of RC-enhanced mitochondrial stress following oxidative insult. Using noninvasive fluorescence probe-coupled laser scanning imaging microscopy, the ability to resist oxidative stress and levels of mROS formation and mitochondrial calcium (mCa2+ were compared between two different astrocyte cell lines, control and ρ0 astrocytes, over time upon oxidative stress. Our results showed that the cytoplasmic membrane becomes permeated with YO-PRO-1 dye at 150 and 130 minutes in RBA-1 and ρ0 astrocytes, respectively. In contrast to RBA-1, 30 minutes after 20 mM H2O2 exposure, ρ0 astrocytes formed marked plasma membrane blebs, lost the ability to retain Mito-R, and showed condensation of nuclei. Importantly, H2O2-induced ROS and accompanied mCa2+ elevation in control showed higher levels than ρ0 at early time point but vice versa at late time point. Our findings underscore dual phase of RC-defective cells harboring less mitochondrial stress due to low RC activity during short-term oxidative stress but augmented mROS-mediated mCa2+ stress during severe oxidative insult.

  10. TaMCA1, a regulator of cell death, is important for the interaction between wheat and Puccinia striiformis.

    Hao, Yingbin; Wang, Xiaojie; Wang, Kang; Li, Huayi; Duan, Xiaoyuan; Tang, Chunlei; Kang, Zhensheng

    2016-01-01

    Metacaspase orthologs are conserved in fungi, protozoa and plants, however, their roles in plant disease resistance are largely unknown. In this study, we identified a Triticum aestivum metacaspase gene, TaMCA1, with three copies located on chromosomes 1A, 1B and 1D. The TaMCA1 protein contained typical structural features of type I metacaspases domains, including an N-terminal pro-domain. Transient expression analyses indicated that TaMCA1 was localized in cytosol and mitochondria. TaMCA1 exhibited no caspase-1 activity in vitro, but was able to inhibit cell death in tobacco and wheat leaves induced by the mouse Bax gene. In addition, the expression level of TaMCA1 was up-regulated following challenge with the Puccinia striiformis f. sp. tritici (Pst). Knockdown of TaMCA1 via virus-induced gene silencing (VIGS) enhanced plant disease resistance to Pst, and the accumulation of hydrogen peroxide (H2O2). Further study showed that TaMCA1 decreased yeast cell resistance similar to the function of yeast metacaspase, and there was no interaction between TaMCA1 and TaLSD1. Based on these combined results, we speculate that TaMCA1, a regulator of cell death, is important during the compatible interaction of wheat and Pst. PMID:27230563

  11. CONCEPT ANALYSIS OF PERCEIVED CONTROL

    Mardiyono Mardiyono

    2011-07-01

    Full Text Available Background. Perceived control is a personality characteristic that contributes psychological adjustment. It was derived from various theories, so that definitions of perceived control were ambiguous meaning. Disclosing concept of perceived control is required.Objective. The analysis aims to identify definition and use of perceived control, examine the basic attributes of perceived control, and the measurements of perceived control.Method. Databases searched for electronic journals and books that were published from 1994 to 2010 were analyzed.Result. Perceived control is personal belief that refers to controllability on behalf of one’s self and ability to control threats or events. The use of perceived control includes maternal, pediatric, medical, surgical, psychiatric, community nursing, and pain management. Perceived control was composed of two dimensions: belief about controllability and belief about ability to control to threats.Conclusion. Instrument of Anxiety Control Questionnaire most closely corresponds to two dimensions: belief about controllability and ability to control. Defining attributes and dimensions of perceived control are useful for developing tool.Keywords: perceived control, controllability, ability to control, and agency

  12. Submarine hydraulic control analysis

    Bower, Michael J.

    1980-01-01

    Approved for public release; distribution unlimited A mathematical model was developed to include line effects in the submarine hydraulic system dynamic performance analysis. The project was undertaken in an effort to demonstrate the necessity of coupling the entire hydraulic power network for an accurate analysis of any of the subsystems rather than the current practice of treating a component loop as an isolated system. It was intended that the line model could be co...

  13. Norms and Standards for Computer Education (MCA, BCA) through Distance Mode.

    Rausaria, R.R., Ed.; Lele, Nalini A., Ed.; Bhushan, Bharat, Ed.

    This document presents the norms and standards for computer education in India through distance mode, including the Masters in Computer Applications (MCA) and Bachelor in Computer Applications (BCA) programs. These norms and standards were considered and approved by the Distance Education Council, Indira Gandhi National Open University (India), at…

  14. Serodiagnosis of leptospirosis in China by the one-point MCA method.

    Arimitsu, Y; Matuhasi, T.; Kobayashi, S; Sato, T; Cui, J.J.

    1987-01-01

    The one-point MCA method is very simple to perform and useful as a screening test in diagnosing leptospirosis in routine clinical laboratories. The kit, sensitized with six serovars occurring in Japan, was also useful in detecting serum antibodies of patients with leptospirosis in China.

  15. Simultaneous detection and differentiation of Entamoeba histolytica, E. dispar, E. moshkovskii, Giardia lamblia and Cryptosporidium spp. in human fecal samples using multiplex PCR and qPCR-MCA.

    Zebardast, Nozhat; Yeganeh, Farshid; Gharavi, Mohammad Javad; Abadi, Alireza; Seyyed Tabaei, Seyyed Javad; Haghighi, Ali

    2016-10-01

    Entamoeba histolytica, Giardia lamblia and Cryptosporidium spp. are common causes of diarrheal and intestinal diseases all over the world. Microscopic methods are useful in the diagnosis of intestinal parasites (IPs), but their sensitivity was assessed approximately 60 percent. Recently, molecular techniques have been used increasingly for the identification and characterization of the parasites. Among those, in this study we have used multiplex PCR and Real-time PCR with melting curve analysis (qPCR-MCA) for simultaneous detection and differentiation of E. histolytica, E. dispar, E. moshkovskii, G. lamblia and Cryptosporidium spp. in human fecal samples. Twenty DNA samples from 12 E. histolytica and 8 E. dispar samples and twenty stool samples confirmed positive for G. lamblia and Cryptosporidium spp. were analyzed. After DNA extraction from the samples, multiplex PCR was done for detection and differentiation of above mentioned parasites. QPCR-MCA was also performed for the detection and differentiation of 11 isolates of above mentioned parasite in a cycle with a time and temperature. Multiplex PCR was able to simultaneous detect and differentiate of above mentioned parasite in a single reaction. QPCR-MCA was able to differentiate genus and species those five protozoa using melting temperature simultaneously at the same time and temperature programs. In total, qPCR-MCA diagnosed 7/11 isolation of E. histolytica, 6/8 isolation of E. dispar, 1/1 E. moshkovskii Laredo, 10/11 G. Lamblia and 6/11 Cryptosporidium spp. Application of multiplex PCR for detection of more than one species in a test in developing countries, at least in reference laboratories has accurate diagnosis and plays a critical role in differentiation of protozoan species. Multiplex PCR assay with a template and multi template had different results and it seems that using a set of primers with one template has higher diagnostic capability in compare with multi template. The results of this study

  16. An unexpected evolution of symptomatic mild middle cerebral artery (MCA stenosis: asymptomatic occlusion

    Malferrari Giovanni

    2011-12-01

    Full Text Available Abstract Background The intracranial localization of large artery disease is recognized as the main cause of ischemic stroke in the world, considering all countries, although its global burden is widely underestimated. Indeed it has been reported more frequently in Asians and African-American people, but the finding of intracranial stenosis as a cause of ischemic stroke is relatively common also in Caucasians. The prognosis of patients with stroke due to intracranial steno-occlusion is strictly dependent on the time of recanalization. Moreover, the course of the vessel involvement is highly dynamic in both directions, improvement or worsening, although several data are derived from the atherosclerotic subtype, compared to other causes. Case description We report the clinical, neurosonological and neuroradiological findings of a young woman, who came to our Stroke Unit because of the abrupt onset of aphasia during her work. An urgent neurosonological examination showed a left M1 MCA stenosis, congruent with the presenting symptoms; magnetic resonance imaging confirmed this finding and identified an acute ischemic lesion on the left MCA territory. The past history of the patient was significant only for a hyperinsulinemic condition, treated with metformine, and a mild overweight. At this time a selective cerebral angiography was not performed because of the patient refusal and she was discharged on antiplatelet and lipid-lowering therapy, having failed to identify autoimmune or inflammatory diseases. Within 1 month, she went back to our attention because of the recurrence of aphasia, lasting about ten minutes. Neuroimaging findings were unchanged, but the patient accepted to undergo a selective cerebral angiography, which showed a mild left distal M1 MCA stenosis. During the follow-up the patient did not experienced any recurrence, but a routine neurosonological examination found an unexpected evolution of the known MCA stenosis, i.e. left M1 MCA

  17. Subcubic Control Flow Analysis Algorithms

    Midtgaard, Jan; Van Horn, David

    We give the first direct subcubic algorithm for performing control flow analysis of higher-order functional programs. Despite the long held belief that inclusion-based flow analysis could not surpass the ``cubic bottleneck, '' we apply known set compression techniques to obtain an algorithm...... that runs in time O(n^3/log n) on a unit cost random-access memory model machine. Moreover, we refine the initial flow analysis into two more precise analyses incorporating notions of reachability. We give subcubic algorithms for these more precise analyses and relate them to an existing analysis from...

  18. An Auto sequence Code to Integrate a Neutron Unfolding Code with thePC-MCA Accuspec

    In a neutron spectrometry using proton recoil method, the neutronunfolding code is needed to unfold the measured proton spectrum to become theneutron spectrum. The process of the unfolding neutron in the existingneutron spectrometry which was successfully installed last year was doneseparately. This manuscript reports that the auto sequence code to integratethe neutron unfolding code UNFSPEC.EXE with the software facility of thePC-MCA Accuspec has been made and run successfully so that the new neutronspectrometry become compact. The auto sequence code was written based on therules in application program facility of PC-MCA Accuspec and then it wascompiled using AC-EXE. Result of the test of the auto sequence code showedthat for binning width 20, 30, and 40 giving a little different spectrumshape. The binning width around 30 gives a better spectrum in mean of givingsmall error compared to the others. (author)

  19. Hemodynamic effects of decompressive craniotomy in MCA infarction: evaluation with perfusion CT

    Decompressive craniotomy in hemispheric infarction has been reported to reduce mortality and improve outcome. Identifying tissue at risk and monitoring the benefit of craniotomy is hardly practical and has not been reported thus far. Perfusion CT was applied before and immediately after decompressive craniotomy in a patient with space-occupying middle cerebral artery (MCA) infarction. Before surgery, perfusion CT revealed malperfused but still vital tissue in the vicinity of the infarction core which returned to normal after decompressive surgery. The final infarct size did not exceed the area of the initial hypodensity on unenhanced CT scan. In critically ill patients, the practicability of perfusion CT allows for demonstration of tissue at risk around the infarct core in space-occupying MCA infarction. Moreover, it may be used to monitor the effect of decompressive craniotomy. (orig.)

  20. NuSTAR ground calibration: The Rainwater Memorial Calibration Facility (RaMCaF)

    Brejnholt, Nicolai; Christensen, Finn Erland; Jakobsen, Anders Clemen;

    2011-01-01

    The Nuclear Spectroscopic Telescope Array (NuSTAR) is a NASA Small Explorer mission that will carry the first focusing hard X-ray (5-80 keV ) telescope to orbit. The ground calibration of the three flight optics was carried out at the Rainwater Memorial Calibration Facility (RaMCaF) built for this...... purpose. In this article we present the facility and its use for the ground calibration of the three optics....

  1. Treatment of a pediatric recurrent fusiform middle cerebral artery (MCA) aneurysm with a flow diverter

    Burrows, Anthony M.; Zipfel, Gregory; Lanzino, Giuseppe

    2012-01-01

    Pediatric patients with aneurysm often have different localizations and morphologies from adults and recurrences are not uncommon after successful clip reconstruction/obliteration. Treatment of a recurrent pediatric aneurysm after clip ligation is a technical challenge. We present the case of an adolescent with a middle cerebral artery (MCA) fusiform aneurysm which recurred following clip reconstruction and bypass. The aneurysm was successfully treated with endovascular flow diversion.

  2. NuSTAR ground calibration: The Rainwater Memorial Calibration Facility (RaMCaF)

    Brejnholt, Nicolai; Christensen, Finn Erland; Jakobsen, Anders Clemen; Hailey, Charles J.; Koglin, Jason E.; Blaedel, Kenneth L.; Stern, Marcela; Thornhill, Doug; Sleator, Clio; Zhang, Shuo; Craig, William W.; Madsen, Kristin K.; Decker, Todd; Pivovaroff, Michael J.; Vogel, Julia K.

    2011-01-01

    The Nuclear Spectroscopic Telescope Array (NuSTAR) is a NASA Small Explorer mission that will carry the first focusing hard X-ray (5-80 keV ) telescope to orbit. The ground calibration of the three flight optics was carried out at the Rainwater Memorial Calibration Facility (RaMCaF) built for this purpose. In this article we present the facility and its use for the ground calibration of the three optics.

  3. NATO-ASTEC-matrix-research environment, information sharing and MCA

    The successful implementations of the NATO-ASTECMATRIX project in Armenia are essential contribution into security, stability and solidarity among regional nations, by applying the best technical expertise to problem solving. Collaboration, networking and capacity-building are means used to accomplish these goals. A further aim is to promote the co-operation with new partners and the ASTEC are creating links between scientists and organizations in formerly separated communities, developing new strategy concentrating support on security related collaborative projects and finding answers to critical questions and a way of connecting nations. The NATO-ASTECMATRIX within Armenia leads to a network of high standards laboratories that will drastically improve the overview and the technical infrastructure for monitoring, accounting and control of CBRN materials in the Armenia. This new infrastructure will enhance the exchange of information on this vital issue via the IRIS. In follow-up phases, it will also help to better define the needs and requirements for a policy to enhance legal tools for the management of these materials, and for the creation of one or several agencies aiming at dealing with wastes or no longer useful materials containing CBRN components in Armenia

  4. Endovascular Mechanical Thrombectomy of an Occluded Superior Division Branch of the Left MCA for Acute Cardioembolic Stroke

    Cardiac embolism accounts for a large proportion of ischemic stroke. Revascularization using systemic or intra-arterial thrombolysis is associated with increasing risks of cerebral hemorrhageas time passes from stroke onset. We report successful mechanicalthrombectomy from a distal branch of the middle cerebral artery (MCA)using a novel technique. A 72-year old man suffered an acute ischemic stroke from an echocardiographically proven ventricular thrombus due toa recent myocardial infarction. Intra-arterial administration of 4 mgrt-PA initiated at 5.7 hours post-ictus failed to recanalize an occluded superior division branch of the left MCA. At 6 hours,symptomatic embolic occlusion persisted. Mechanical extraction of the clot using an Attracter-18 device (Target Therapeutics, Freemont, CA) resulted in immediate recanalization of the MCA branch. Attracter-18 for acute occlusion of MCA branches may be considered in selected patients who fail conventional thrombolysis or are nearing closure of the therapeutic window for use of thrombolytic agents

  5. Effects of some ruthenium chelates on MCa mammary carcinoma and on TLX5 lymphoma in mice.

    Bregant, F; Pacor, S; Ghosh, S; Chattopadhyay, S K; Sava, G

    1993-01-01

    A group of four Ruthenium chelates of the mixed hard/soft N-S donor ligands 2-formylpyridine (4-H/4-phenyl)thiosemicarbazone has been studied in the experimental models of MCa mammary carcinoma and TLX5 lymphoma in the CBA mouse. Although all the four tested complexes, bis-[2-formylpyridine(4- phenyl)thiosemicarbazone]ruthenium(II)chloride]Ru(L1)(L1H)Cl, 1], [2-formylpyridine(4-phenyl)thiosemicarbazone]ruthenium(II)-mu- trichloro chloro(imidazole)ruthenium(III)monomethanolate [Ru2(L1)(imz)Cl4.CH3OH, 9]. [2-formylpyridine(4-phenyl)thiosemicarbazone]dichloroimidazoler uthenium(II) [Ru(L1H)(imz)Cl2,10] and bis[2- formylpyridinethiosemicarbazone]ruthenium(II) perchlorate, dihydrate [Ru(L)(LH)ClO4.2H2O, 16], reduced the formation of lung metastases at the same extent only compound 1 caused parallel inhibition of the growth of the primary tumor. The chemical nature of the tested compounds seems to determine the nature of the antitumor effects and the bis-chelates are found to be endowed with greater cytotoxic properties towards primary tumor than the monochelates. This opens up a very interesting point, whether it is the presence of two chelate rings around the Ruthenium(II)/(III) acceptor centre or the increase in the number of the soft (S) donor centers that generates greater cytotoxic properties in the corresponding ruthenium complexes. As far as the reduction of the metastasis formation is concerned, it appears that among the four Ruthenium chelates tested, it is possible to identify structures capable of controlling the spread of tumor to the lungs in the absence of significant cytotoxicity for tumor cells. This finding appears of importance in that it indicates the possibility of a specific mechanism of interaction with cells of the metastatic tumor. In this context it appears necessary to investigate other congeners of this "family" with more sulfur donor sites and particularly those with better water solubility. PMID:8352519

  6. Best interests in the MCA 2005--what can healthcare law learn from family law?

    Choudhry, Shazia

    2008-09-01

    The 'best interests' standard is a highly seductive standard in English law. Not only does it appear to be fairly uncontroversial but it also presents as the most sensible, objective and 'fair' method of dealing with decision making on behalf of those who are perceived to be the most vulnerable within society. This article aims to provide a critical appraisal of how the standard has been applied within family law, to outline how the standard is to be applied within healthcare law and, finally, to assess the relevance of the family law experience of the best interests standard to the operation of the standards as envisaged by the MCA. PMID:18677570

  7. Isomorphous miscibility in MEO4 (scheelite) - LnVO4 (zircon) systems, where M=Ca, Sr, Ba, Cd, Pb; E=Mo, W; Ln=Y and lanthanides

    Method of X-ray phase analysis was used to study phase relations in MEO4 (scheelite) - LnVO4 (zircon) systems, where M=Ca, Sr, Ba, Cd, Pb; E=Mo, W; Ln=Y, Ce, Nd, Eu. Formation of limited solid solutions M1-xVxO4 was established. Evaluation of isomorphous miscibility in scheelite-zircon systems according to the statements of energy theory of isomorphous miscibility was conducted

  8. Detection of methylation in promoter sequences by melting curve analysis-based semiquantitative real time PCR

    Lázcoz Paula

    2008-02-01

    Full Text Available Abstract Background We present two melting curve analysis (MCA-based semiquantitative real time PCR techniques to detect the promoter methylation status of genes. The first, MCA-MSP, follows the same principle as standard MSP but it is performed in a real time thermalcycler with results being visualized in a melting curve. The second, MCA-Meth, uses a single pair of primers designed with no CpGs in its sequence. These primers amplify both unmethylated and methylated sequences. In clinical applications the MSP technique has revolutionized methylation detection by simplifying the analysis to a PCR-based protocol. MCA-analysis based techniques may be able to further improve and simplify methylation analyses by reducing starting DNA amounts, by introducing an all-in-one tube reaction and by eliminating a final gel stage for visualization of the result. The current study aimed at investigating the feasibility of both MCA-MSP and MCA-Meth in the analysis of promoter methylation, and at defining potential advantages and shortcomings in comparison to currently implemented techniques, i.e. bisulfite sequencing and standard MSP. Methods The promoters of the RASSF1A (3p21.3, BLU (3p21.3 and MGMT (10q26 genes were analyzed by MCA-MSP and MCA-Meth in 13 astrocytoma samples, 6 high grade glioma cell lines and 4 neuroblastoma cell lines. The data were compared with standard MSP and validated by bisulfite sequencing. Results Both, MCA-MSP and MCA-Meth, successfully determined promoter methylation. MCA-MSP provided information similar to standard MSP analyses. However the analysis was possible in a single tube and avoided the gel stage. MCA-Meth proved to be useful in samples with intermediate methylation status, reflected by a melting curve position shift in dependence on methylation extent. Conclusion We propose MCA-MSP and MCA-Meth as alternative or supplementary techniques to MSP or bisulfite sequencing.

  9. The Foetal ′Mind′ as a Reflection of its Inner Self: Evidence from Colour Doppler Ultrasound of Foetal MCA

    Sushil Ghanshyam Kachewar

    2012-01-01

    Full Text Available The unborn healthy foetus is looked upon as a blessing by one and all. A plethora of thoughts arise in the brains of expectant parents. But what goes on in the brain of the yet unborn still remains a mystery. ′Foetal mind′ is a reflection of functions of its organs of sense, an instrument of knowledge that may even be reduced to machine to demonstrate the effect of sense organs and brain contact. Testimony to this fact are the various waveform patterns obtained non-invasively from the foetal Middle Cerebral Artery (MCA by using Colour Doppler Ultrasound. Our study, conducted for evaluating the foetal MCA in a rural obstetric population in Maharashtra, India, explains how the MCA - a major artery supplying foetal brain, can give abundant information about foetal heart and foetal stress. When only the foetal heart is stressed by the presence of arrhythmias or ectopic beats, these changes are manifest in the foetal MCA velocity waveform pattern as seen on Colour Doppler study. When the entire foetus is under stress, as in cases of intra uterine growth retardation (IUGR, changes again manifest in the foetal MCA velocity waveform pattern and are designated as the foetal Brain Sparing Effect. Thus scientific evaluation of foetal MCA waveform can objectively demonstrate that the overtly non-communicating foetal brain indeed remains an internal organ of sense and a vital instrument of knowledge to clarify the various effects of sense organs and brain contact. Although the brain parenchyma or cerebral metabolism has not been studied here, cerebral vessels serve as a window to cerebral metabolism, as auto regulatory function of brain leads to changes in haemodynamics of cerebral vessels. Also, like other vessels, MCA mirrors foetal distress and IUGR; but unlike other vessels, e.g. the umbilical or uterine artery, which show these changes in the form of reduction or even reversal of diastolic flow, MCA shows an increase in diastolic component due to

  10. Detection of focal hypoxic-ischemic injury and neuronal stress in a rodent model of unilateral MCA occlusion/reperfusion using radiolabeled annexin V

    In this study we wished to determine whether technetium-99m annexin V, an in vivo marker of cellular injury and death, could be used to noninvasively monitor neuronal injury following focal middle cerebral artery (MCA) occlusion/reperfusion injury. Sixteen adult male Sprague-Dawley rats (along with four controls) underwent left (unilateral) MCA intraluminal beaded thread occlusion for 2 h followed by reperfusion. One hour following tail vein injection of 5-10 mCi of 99mTc-annexin V, animals underwent either single-photon emission computerized tomography (SPECT) or autoradiography followed by immunohistochemical analyses. There was abnormal, bilateral, multifocal uptake of 99mTc-annexin V in each cerebral hemisphere as seen by both SPECT and autoradiography at 4 h and 1, 3, and 7 days after initiation of occlusion. The average maximal annexin V uptake at 4 h was 310%±85% and 365%±151% above control values (P<0.006) within the right and left hemispheres, respectively, peaking on day 3 with values of 925%±734% and 1,194%±643% (P<0.03) that decreased by day 7 to 489%±233% and 785%±225% (P<0.01). Total lesional volume of the left hemisphere was 226%, 261%, and 451% (P<0.03) larger than the right at 4, 24, and 72 h after injury, respectively. Annexin V localized to the cytoplasm of injured neurons ipsilateral to the site of injury as well as to otherwise normal-appearing neurons of the contralateral hemisphere as confirmed by dual fluorescent microscopy. It is concluded that there is abnormal bilateral, multifocal annexin V uptake, greater on the left than on the right side, within 4 h of unilateral left MCA ischemic injury and that the uptake peaks at 3 days and decreases by 7 days after injury. This pattern suggests that neuronal stress may play a role in the response of the brain to focal injury and be responsible for annexin V uptake outside the region of ischemic insult. (orig.)

  11. Controllability analysis of decentralised linear controllers for polymeric fuel cells

    Serra, Maria; Aguado, Joaquin; Ansede, Xavier; Riera, Jordi [Institut de Robotica i Informatica Industrial, Universitat Politecnica de Catalunya - Consejo Superior de Investigaciones Cientificas, C. Llorens i Artigas 4, 08028 Barcelona (Spain)

    2005-10-10

    This work deals with the control of polymeric fuel cells. It includes a linear analysis of the system at different operating points, the comparison and selection of different control structures, and the validation of the controlled system by simulation. The work is based on a complex non linear model which has been linearised at several operating points. The linear analysis tools used are the Morari resiliency index, the condition number, and the relative gain array. These techniques are employed to compare the controllability of the system with different control structures and at different operating conditions. According to the results, the most promising control structures are selected and their performance with PI based diagonal controllers is evaluated through simulations with the complete non linear model. The range of operability of the examined control structures is compared. Conclusions indicate good performance of several diagonal linear controllers. However, very few have a wide operability range. (author)

  12. RENT CONTROL: A COMPARATIVE ANALYSIS

    Sue-Mari Maass

    2012-11-01

    Full Text Available Recent case law shows that vulnerable, previously disadvantaged private sector tenants are currently facing eviction orders – and consequential homelessness – on the basis that their leases have expired. In terms of the case law it is evident that once their leases have expired, these households do not have access to alternative accommodation. In terms of the Constitution, this group of marginalised tenants have a constitutional right of access to adequate housing and a right to occupy land with legally secure tenure. The purpose of this article is to critically analyse a number of legislative interventions, and specifically rent control, that were imposed in various jurisdictions in order to provide strengthened tenure protection for tenants. The rationale for this analysis is to determine whether the current South African landlord-tenant regime is able to provide adequate tenure protection for vulnerable tenants and therefore in the process of transforming in line with the Constitution. The legal construction of rent control was adopted in pre-1994 South Africa, England and New York City to provide substantive tenure protection for tenants during housing shortages. These statutory interventions in the different private rental markets were justified on the basis that there was a general need to protect tenants against exploitation by landlords. However, the justification for the persistent imposition of rent control in New York City is different since it protects a minority group of financially weak tenants against homelessness. The English landlord-tenant regime highlights the importance of a well-structured social sector that can provide secure, long-term housing options for low-income households who are struggling to access the private rental sector. Additionally, the English rental housing framework shows that if the social sector is functioning as a "safety net" for low-income households, the private sector would be able to uphold

  13. Measurement Control Workshop Instructional Materials

    Gibbs, Philip [Brookhaven National Lab. (BNL), Upton, NY (United States); Crawford, Cary [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); McGinnis, Brent [Pacific Northwest National Lab. (PNNL), Richland, WA (United States) and Insolves LLC

    2014-04-01

    A workshop to teach the essential elements of an effective nuclear materials control and accountability (MC&A) programs are outlined, along with the modes of Instruction, and the roles and responsibilities of participants in the workshop.

  14. Video Game Control Dimensionality Analysis

    Mustaquim, Moyen; Nyström, Tobias

    2014-01-01

    In this paper we have studied the video games control dimensionality and its effects on the traditional way of interpreting difficulty and familiarity in games. This paper presents the findings in which we have studied the Xbox 360 console’s games control dimensionality. Multivariate statistical operations were performed on the collected data from 83 different games of Xbox 360. It was found that the player’s perceived level of familiarity and difficulty can be influenced by the game control ...

  15. Modular Control Flow Analysis for Libraries

    Probst, Christian W.

    2002-01-01

    One problem in analyzing object oriented languages is that the exact control flow graph is not known statically due to dynamic dispatching. However, this is needed in order to apply the large class of known interprocedural analysis. Control Flow Analysis in the object oriented setting aims at...... determining run-time types of variables, thus allowing to possibly targeted method implementations. We present a flow sensitive analysis that allows separate handling of libraries and thereby efficient analysis of whole programs....

  16. Iterative Learning Controller - Rate of Convergence Analysis

    Shaikh, I. U. H., Khalili, H. H., Brown, M.

    2010-01-01

    Iterative Learning Control (ILC) is one of the Intelligent Control Systems which improves the transient performance of systems operating in a repetitive manner. After each repetition or batch, the controller learns to produce the best possible control input signal. Convergence analysis of the first order D - type ILC algorithm has been investigated. It generates the control input update for the next batch based on the derivative of the error between the desired and actual outputs during the c...

  17. Selecting supplier combination based on fuzzy multicriteria analysis

    Han, Zhi-Qiu; Luo, Xin-Xing; Chen, Xiao-Hong; Yang, Wu-E.

    2015-07-01

    Existing multicriteria analysis (MCA) methods are probably ineffective in selecting a supplier combination. Thus, an MCA-based fuzzy 0-1 programming method is introduced. The programming relates to a simple MCA matrix that is used to select a single supplier. By solving the programming, the most feasible combination of suppliers is selected. Importantly, this result differs from selecting suppliers one by one according to a single-selection order, which is used to rank sole suppliers in existing MCA methods. An example highlights such difference and illustrates the proposed method.

  18. Control rod drive mechanisms seismic analysis

    In the Taishan joint-design, in order to finish Control Rod Drive Mechanism (CRDM) seismic analysis, a response spectrum analysis in combination with quasi-static analysis and a time history analysis are performed according to the different design stages and inputs. The simulated and simplified model of nonlinear structure is studied in the basic design stage; the translation of seismic input data and the use of nonlinear elements are studied in the detailed design stage. (authors)

  19. Stray light analysis and control

    Fest, Eric

    2013-01-01

    Stray light is defined as unwanted light in an optical system, a familiar concept for anyone who has taken a photograph with the sun in or near their camera's field of view. This book addresses stray light terminology, radiometry, and the physics of stray light mechanisms, such as surface roughness scatter and ghost reflections. The most-efficient ways of using stray light analysis software packages are included. The book also demonstrates how the basic principles are applied in the design, fabrication, and testing phases of optical system development.

  20. Quality control in radiochemical analysis

    Whenever analytical data are to be used as a basis for a scientific study or even for monitoring purposes it is necessary to have information on the quality of the analyses. It is much better if this quality can be expressed in numerical form rather than subjectively and it is also better if the data are part of a continuing programme. All laboratories are involved in this question of analytical quality but the degree to which they develop the required information is highly variable. The present paper attempts to describe an ideal system and to present some data relating to analysis of seawater

  1. LANMAS Gap Analysis Report

    Parrish, C.; Yee, W.; Okuda, V.; Watson, B.; Storch, N

    2000-08-25

    In July, 2000, the Controlled Materials Accountability and Tracking System (COMATS) Team, with the assistance of a representative of the Local Area Network Materials Accountability System (LANMAS) development team from Savannah River, performed an evaluation to enumerate and qualify differences between the current LANMAS functionality and LLNL requirements as implemented by COMATS. The differences found range from minor to serious deficiencies of LANMAS in relation to current LLNL MC&A practice. Therefore, we recommend a gradual integration of LANMAS into a hybrid system which uses LANMAS to satisfy DOE/NNSA MC&A and reporting requirements and uses COMATS to satisfy LLNL-specific MC&A and operational requirements.

  2. Roles of Edc3 in the oxidative stress response and CaMCA1-encoded metacaspase expression in Candida albicans.

    Jung, Jong-Hwan; Kim, Jinmi

    2014-11-01

    The Edc3 protein is an enhancer of mRNA decapping, and acts as a scaffold protein for the mRNA granules that are known as processing bodies in yeast. In the pathogenic yeast Candida albicans, various stresses, such as glucose depletion, oxidative stress, and filamentation defects, induce the accumulation of processing bodies. Here, we report that the edc3/edc3 deletion strain showed increased resistance to various stresses, including hydrogen peroxide, acetic acid, and high temperature. Oxidative stress is known to induce the intracellular accumulation of reactive oxygen species (ROS) and apoptotic cell death in C. albicans. We found that the ROS level was lower in edc3/edc3 cells than in wild-type cells following oxidative stress. We also observed that expression of the metacaspase gene CaMCA1 was decreased in edc3/edc3 cells. Overexpression of CaMCA1 suppressed the decreased accumulation of ROS and the increased resistance to hydrogen peroxide in edc3/edc3 cells. The catalase Cat1 and the superoxide dismutase Sod1 were upregulated in edc3/edc3 cells as compared with wild-type cells. On the basis of these findings, we suggest that EDC3 plays a critical role in the expression of CaMCA1 and the oxidative stress response in C. albicans. PMID:25158786

  3. Thermal and stress analysis of control rod

    In order to survey the mechanical integrity of a control rod in the high temperature core of the VHTR, thermal analysis and thermal stress analysis were carried out by means of calculus of finite differentials and finite element methods for the plant under the normal operating condition as well as under several abnormal conditions. The results of the analyses have been applied to refine the mechanical design of the control rod

  4. Development of a robotized sample changing system for activation analysis

    An automatic sample changing system with a small robot has been developed and constructed for instrumental neutron activation analysis (INAA). The developed system composed of a model A151 small robot (CRS Plus Inc., Canada), a NEC PC-980m2 personal computer having two of 1 Mbyte floppy-disk drivers, a NAIG NLAB-MCA multichannel analyzer (Toshiba), Ge detector settled in a low background shield and a tray stored 20 dishes containing a sample. The robot has a five-axis articulated arm (reach: 560 mm, payload: 2 kg, speed: 17 m/s, repeatability: 0.13 mm, weight: 17 kg). The robot and the multichannel analyzer (MCA) are controlled by the personal computer via RS-232C or GP-IB interface. (author)

  5. Control Flow Analysis for BioAmbients

    Nielson, Flemming; Nielson, Hanne Riis; Priami, C.; Rosa, D. Schuch da

    2007-01-01

    This paper presents a static analysis for investigating properties of biological systems specified in BioAmbients. We exploit the control flow analysis to decode the bindings of variables induced by communications and to build a relation of the ambients that can interact with each other. We...

  6. Reconfigurability Analysis Method for Spacecraft Autonomous Control

    Dayi Wang; Chengrui Liu

    2014-01-01

    As a critical requirement for spacecraft autonomous control, reconfigurability should be considered in design stage of spacecrafts by involving effective reconfigurability analysis method in guiding system designs. In this paper, a novel reconfigurability analysis method is proposed for spacecraft design. First, some basic definitions regarding spacecraft reconfigurability are given. Then, based on function tree theory, a reconfigurability modeling approach is established to properly describe...

  7. The vestibular control of balance after stroke

    Marsden, J. F.; Playford, E. D.; Day, B. L.

    2005-01-01

    Objectives: To examine vestibular control of balance in those who recovered the ability to stand after middle cerebral artery (MCA) stroke.Methods: Sixteen patients with MCA stroke were compared with 10 age matched controls. Two additional patients were studied with isolated corticospinal tract lesions, one each at the level of the pons and medulla. Vestibular evoked postural responses were obtained using galvanic vestibular stimulation (GVS) while patients stood with their eyes closed and he...

  8. Aircraft Loss-of-Control Accident Analysis

    Belcastro, Christine M.; Foster, John V.

    2010-01-01

    Loss of control remains one of the largest contributors to fatal aircraft accidents worldwide. Aircraft loss-of-control accidents are complex in that they can result from numerous causal and contributing factors acting alone or (more often) in combination. Hence, there is no single intervention strategy to prevent these accidents. To gain a better understanding into aircraft loss-of-control events and possible intervention strategies, this paper presents a detailed analysis of loss-of-control accident data (predominantly from Part 121), including worst case combinations of causal and contributing factors and their sequencing. Future potential risks are also considered.

  9. Integrated tools for control-system analysis

    Ostroff, Aaron J.; Proffitt, Melissa S.; Clark, David R.

    1989-01-01

    The basic functions embedded within a user friendly software package (MATRIXx) are used to provide a high level systems approach to the analysis of linear control systems. Various control system analysis configurations are assembled automatically to minimize the amount of work by the user. Interactive decision making is incorporated via menu options and at selected points, such as in the plotting section, by inputting data. There are five evaluations such as the singular value robustness test, singular value loop transfer frequency response, Bode frequency response, steady-state covariance analysis, and closed-loop eigenvalues. Another section describes time response simulations. A time response for random white noise disturbance is available. The configurations and key equations used for each type of analysis, the restrictions that apply, the type of data required, and an example problem are described. One approach for integrating the design and analysis tools is also presented.

  10. Analysis and design of hybrid control systems

    Malmborg, J.

    1998-05-01

    Different aspects of hybrid control systems are treated: analysis, simulation, design and implementation. A systematic methodology using extended Lyapunov theory for design of hybrid systems is developed. The methodology is based on conventional control designs in separate regions together with a switching strategy. Dynamics are not well defined if the control design methods lead to fast mode switching. The dynamics depend on the salient features of the implementation of the mode switches. A theorem for the stability of second order switching together with the resulting dynamics is derived. The dynamics on an intersection of two sliding sets are defined for two relays working on different time scales. The current simulation packages have problems modeling and simulating hybrid systems. It is shown how fast mode switches can be found before or during simulation. The necessary analysis work is a very small overhead for a modern simulation tool. To get some experience from practical problems with hybrid control the switching strategy is implemented in two different software environments. In one of them a time-optimal controller is added to an existing PID controller on a commercial control system. Successful experiments with this hybrid controller shows the practical use of the method 78 refs, 51 figs, 2 tabs

  11. The Mechanical Control Absorber reactivity dependence on the enrichment and burn-up in Candu-SEU super-cells

    Balaceanu, Victoria; Constantin, Marin [Institute for Nuclear research, Pitesti (Romania)

    2008-07-01

    The objective of this work is to highlight some aspects of the local neutronic behaviour of the Candu SEU-43 fuel bundles (Slightly Enriched Uranium fuel bundles with 43 fuel elements). More exactly, the study refers to the dependence of some local neutronic parameters, mainly the reactivity, on the enrichment and the burn-up of the fuel. It was taken in consideration two types of super-cells: reference supercell (containing only fuel bundle and moderator) and perturbed supercell (containing fuel bundle, moderator and additionally a strong reactivity device). The considered reactivity device is the Mechanical Control Absorber (MCA). The performed parameters are: k{sub eff}. values, MCA reactivities and flux distributions. For reaching this objective, it is used a local neutronic calculation methodology based on WIMS and PIJXYZ codes. The paper ends with an analysis of the obtained results. (authors)

  12. Importance of criteria weights in composite appraisal of transport projects – a robustness analysis

    Jensen, Anders Vestergaard

    2010-01-01

    This paper presents a framework for estimating the robustness of appraisal of transport projects using composite appraisal methodology which makes use of both cost benefit analysis (CBA) and multi criteria analysis (MCA). The setting of criteria weights in MCA is often seen as the most subjective...

  13. Applied behavior analysis and statistical process control?

    Hopkins, B. L.

    1995-01-01

    This paper examines Pfadt and Wheeler's (1995) suggestions that the methods of statistical process control (SPC) be incorporated into applied behavior analysis. The research strategies of SPC are examined and compared to those of applied behavior analysis. I argue that the statistical methods that are a part of SPC would likely reduce applied behavior analysts' intimate contacts with the problems with which they deal and would, therefore, likely yield poor treatment and research decisions. Ex...

  14. Adult Moyamoya disease: 320-Multidetector row CT for evaluation of revascularization in STA–MCA bypasses surgery

    Tian, Bing; Xu, Bing; Liu, Qi; Hao, Qiang; Lu, Jianping, E-mail: cjr.lujianping@vip.163.com

    2013-12-01

    Purpose: To evaluate the utility of 320-multidetector row whole-brain computed tomography perfusion (WBCTP) and whole-head subtracted dynamic angiography (WHSDCTA) for assessing the revascularization of blood flow after superficial temporal artery (STA) to middle cerebral artery (MCA) bypass surgery in adults with Moyamoya disease (MD) in the short and long term. Patients and methods: 320-multidetector row WBCTP and WHSDCTA were applied in 20 patients with MD before and after surgery (for an average of 3 days and 3 months). The bypass arteries were investigated using WHSDCTA and compared with DSA. The regions of interests (ROIs) in the surgical and mirror sides of the cerebral cortex were drawn on a Vitrea Workstation. Cerebral blood volume (CBV), time to peak (TTP), cerebral blood flow (CBF), mean transit time (MTT), and delay time were recorded. Preoperative and postoperative perfusion parameters in the MCA distribution were compared using the paired t-test. Results: WHSDCTA could clearly demonstrate 24 bypass arteries in 26 arteries for 20 patients, results which were in accordance with the results of digital subtraction angiography (DSA). When comparing preoperative values to those within 3 days after surgery, only TTP and delay time were significantly different (P < 0.05). Values of CBV, TTP, CBF, delay time, and MTT 3 months after surgery were significantly different (P < 0.05) from those of preoperative perfusion. Conclusion: These data suggest that 320-multidetector row WBCTP and WHSDCTA can be used to evaluate the revascularization of blood flow after STA–MCA bypass surgery in patients with MD in the short and long term.

  15. Adult Moyamoya disease: 320-Multidetector row CT for evaluation of revascularization in STA–MCA bypasses surgery

    Purpose: To evaluate the utility of 320-multidetector row whole-brain computed tomography perfusion (WBCTP) and whole-head subtracted dynamic angiography (WHSDCTA) for assessing the revascularization of blood flow after superficial temporal artery (STA) to middle cerebral artery (MCA) bypass surgery in adults with Moyamoya disease (MD) in the short and long term. Patients and methods: 320-multidetector row WBCTP and WHSDCTA were applied in 20 patients with MD before and after surgery (for an average of 3 days and 3 months). The bypass arteries were investigated using WHSDCTA and compared with DSA. The regions of interests (ROIs) in the surgical and mirror sides of the cerebral cortex were drawn on a Vitrea Workstation. Cerebral blood volume (CBV), time to peak (TTP), cerebral blood flow (CBF), mean transit time (MTT), and delay time were recorded. Preoperative and postoperative perfusion parameters in the MCA distribution were compared using the paired t-test. Results: WHSDCTA could clearly demonstrate 24 bypass arteries in 26 arteries for 20 patients, results which were in accordance with the results of digital subtraction angiography (DSA). When comparing preoperative values to those within 3 days after surgery, only TTP and delay time were significantly different (P < 0.05). Values of CBV, TTP, CBF, delay time, and MTT 3 months after surgery were significantly different (P < 0.05) from those of preoperative perfusion. Conclusion: These data suggest that 320-multidetector row WBCTP and WHSDCTA can be used to evaluate the revascularization of blood flow after STA–MCA bypass surgery in patients with MD in the short and long term

  16. Applied Behavior Analysis and Statistical Process Control?

    Hopkins, B. L.

    1995-01-01

    Incorporating statistical process control (SPC) methods into applied behavior analysis is discussed. It is claimed that SPC methods would likely reduce applied behavior analysts' intimate contacts with problems and would likely yield poor treatment and research decisions. Cases and data presented by Pfadt and Wheeler (1995) are cited as examples.…

  17. Power system stability modelling, analysis and control

    Sallam, Abdelhay A

    2015-01-01

    This book provides a comprehensive treatment of the subject from both a physical and mathematical perspective and covers a range of topics including modelling, computation of load flow in the transmission grid, stability analysis under both steady-state and disturbed conditions, and appropriate controls to enhance stability.

  18. SURFACE TEXTURE ANALYSIS FOR FUNCTIONALITY CONTROL

    De Chiffre, Leonardo; Andreasen, Jan Lasson; Tosello, Guido

    This document is used in connection with three exercises of 3 hours duration as a part of the course VISION ONLINE – One week course on Precision & Nanometrology. The exercises concern surface texture analysis for functionality control, in connection with three different case stories. This document...

  19. Safety analysis of control rod drive computers

    The analysis of the most significant user programmes revealed no errors in these programmes. The evaluation of approximately 82 cumulated years of operation demonstrated that the operating system of the control rod positioning processor has a reliability that is sufficiently good for the tasks this computer has to fulfil. Computers can be used for safety relevant tasks. The experience gained with the control rod positioning processor confirms that computers are not less reliable than conventional instrumentation and control system for comparable tasks. The examination and evaluation of computers for safety relevant tasks can be done with programme analysis or statistical evaluation of the operating experience. Programme analysis is recommended for seldom used and well structured programmes. For programmes with a long, cumulated operating time a statistical evaluation is more advisable. The effort for examination and evaluation is not greater than the corresponding effort for conventional instrumentation and control systems. This project has also revealed that, where it is technologically sensible, process controlling computers or microprocessors can be qualified for safety relevant tasks without undue effort. (orig./HP)

  20. Financial Analysis, Budgeting, Decision and Control

    Mariana Rodica TIRLEA

    2013-12-01

    Full Text Available The economic processes taking place in the economic environment are stochastic processes that involve and imply risks, arising from product diversification, competition, financial derivatives transactions: swaps, futures, options and from the large number of actors involved in the stock market with a higher or a smaller uncertainty degree. Competition and competitiveness, led to major and rapid change in the business environment, they determined actors participating in the economy to find solutions and methods of collecting and processing data, in such a way that, after being transformed into information they quickly help based on their analysis in decision making, planning and financial forecasting, having an effect on increasing their economic efficiency. In these circumstances the financial analysis, decision, forecasting and control, should be based on quality information that should be a value creation source. The active nature of the financial function implies the existence of a substantially large share of financial analysis, financial decision, forecasting and control.

  1. Evaluating control displays with the Engineering Control Analysis Tool (ECAT)

    In the Nuclear Power Industry increased use of automated sensors and advanced control systems is expected to reduce and/or change manning requirements. However, critical questions remain regarding the extent to which safety will be compromised if the cognitive workload associated with monitoring multiple automated systems is increased. Can operators/engineers maintain an acceptable level of performance if they are required to supervise multiple automated systems and respond appropriately to off-normal conditions? The interface to/from the automated systems must provide the information necessary for making appropriate decisions regarding intervention in the automated process, but be designed so that the cognitive load is neither too high nor too low for the operator who is responsible for the monitoring and decision making. This paper will describe a new tool that was developed to enhance the ability of human systems integration (HSI) professionals and systems engineers to identify operational tasks in which a high potential for human overload and error can be expected. The tool is entitled the Engineering Control Analysis Tool (ECAT). ECAT was designed and developed to assist in the analysis of: Reliability Centered Maintenance (RCM), operator task requirements, human error probabilities, workload prediction, potential control and display problems, and potential panel layout problems. (authors)

  2. Induction motors. Analysis and torque control

    Amin, B. [INRETS, Arcueil (France)

    2002-07-01

    This book provides a thorough approach for mastering the behavior and operation of induction motors, an essential device in the modern industrial world. Its way of presentation renders this book suitable for selfteaching by students, engineers, and researchers in the field of electrical engineering. It covers the modern theory of induction motor applications and control methods. The transient analysis of both three-phase and single-phase induction motors as well as that of the double-cage motors are developed. The principles of such modern control methods as Field-Oriented Control, Direct Torque Control and Computed Charges Acceleration Method are clearly treated in this monograph. Numerous equations, simulations, and figures are presented. (orig.)

  3. Modeling Controller Tasks for Safety Analysis

    Brown, Molly; Leveson, Nancy G.

    1998-01-01

    As control systems become more complex, the use of automated control has increased. At the same time, the role of the human operator has changed from primary system controller to supervisor or monitor. Safe design of the human computer interaction becomes more difficult. In this paper, we present a visual task modeling language that can be used by system designers to model human-computer interactions. The visual models can be translated into SpecTRM-RL, a blackbox specification language for modeling the automated portion of the control system. The SpecTRM-RL suite of analysis tools allow the designer to perform formal and informal safety analyses on the task model in isolation or integrated with the rest of the modeled system.

  4. Analysis and control of distributed cooperative systems.

    Feddema, John Todd; Parker, Eric Paul; Wagner, John S.; Schoenwald, David Alan

    2004-09-01

    As part of DARPA Information Processing Technology Office (IPTO) Software for Distributed Robotics (SDR) Program, Sandia National Laboratories has developed analysis and control software for coordinating tens to thousands of autonomous cooperative robotic agents (primarily unmanned ground vehicles) performing military operations such as reconnaissance, surveillance and target acquisition; countermine and explosive ordnance disposal; force protection and physical security; and logistics support. Due to the nature of these applications, the control techniques must be distributed, and they must not rely on high bandwidth communication between agents. At the same time, a single soldier must easily direct these large-scale systems. Finally, the control techniques must be provably convergent so as not to cause undo harm to civilians. In this project, provably convergent, moderate communication bandwidth, distributed control algorithms have been developed that can be regulated by a single soldier. We have simulated in great detail the control of low numbers of vehicles (up to 20) navigating throughout a building, and we have simulated in lesser detail the control of larger numbers of vehicles (up to 1000) trying to locate several targets in a large outdoor facility. Finally, we have experimentally validated the resulting control algorithms on smaller numbers of autonomous vehicles.

  5. Statistical quality control through overall vibration analysis

    Carnero, M. a. Carmen; González-Palma, Rafael; Almorza, David; Mayorga, Pedro; López-Escobar, Carlos

    2010-05-01

    The present study introduces the concept of statistical quality control in automotive wheel bearings manufacturing processes. Defects on products under analysis can have a direct influence on passengers' safety and comfort. At present, the use of vibration analysis on machine tools for quality control purposes is not very extensive in manufacturing facilities. Noise and vibration are common quality problems in bearings. These failure modes likely occur under certain operating conditions and do not require high vibration amplitudes but relate to certain vibration frequencies. The vibration frequencies are affected by the type of surface problems (chattering) of ball races that are generated through grinding processes. The purpose of this paper is to identify grinding process variables that affect the quality of bearings by using statistical principles in the field of machine tools. In addition, an evaluation of the quality results of the finished parts under different combinations of process variables is assessed. This paper intends to establish the foundations to predict the quality of the products through the analysis of self-induced vibrations during the contact between the grinding wheel and the parts. To achieve this goal, the overall self-induced vibration readings under different combinations of process variables are analysed using statistical tools. The analysis of data and design of experiments follows a classical approach, considering all potential interactions between variables. The analysis of data is conducted through analysis of variance (ANOVA) for data sets that meet normality and homoscedasticity criteria. This paper utilizes different statistical tools to support the conclusions such as chi squared, Shapiro-Wilks, symmetry, Kurtosis, Cochran, Hartlett, and Hartley and Krushal-Wallis. The analysis presented is the starting point to extend the use of predictive techniques (vibration analysis) for quality control. This paper demonstrates the existence

  6. Control system design and analysis using the INteractive Controls Analysis (INCA) program

    Bauer, Frank H.; Downing, John P.

    1987-01-01

    The INteractive Controls Analysis (INCA) program was developed at the Goddard Space Flight Center to provide a user friendly efficient environment for the design and analysis of linear control systems. Since its inception, INCA has found extensive use in the design, development, and analysis of control systems for spacecraft, instruments, robotics, and pointing systems. Moreover, the results of the analytic tools imbedded in INCA have been flight proven with at least three currently orbiting spacecraft. This paper describes the INCA program and illustrates, using a flight proven example, how the package can perform complex design analyses with relative ease.

  7. Ivy signs on FLAIR images before and after STA-MCA anastomosis in patients with Moyamoya disease

    Ideguchi, Reiko; Enokizono, Mikako; Uetani, Masataka (Dept. of Radiological Sciences, Nagasaki Univ. Graduate School of Biomedical Sciences, Nagasaki (Japan)), e-mail: qqtt37gd9@forest.ocn.ne.jp; Morikawa, Minoru (Dept. of Radiology, Nagasaki Univ. School of Medicine, Nagasaki (Japan)); Ogawa, Yoji (Dept. of Radiology, Hanwa Daini Senboku Hospital, Osaka (Japan)); Nagata, Izumi (Dept. of Neurosurgery, Nagasaki Univ. School of Medicine, Nagasaki (Japan))

    2011-04-15

    Background: Leptomeningeal high signal intensity (ivy sign) on fluid-attenuated inversion-recovery (FLAIR) MR imaging is one of the features of Moyamoya disease. However, the correlation between ivy sign and cerebral perfusion status has not been fully evaluated. Purpose: To characterize ivy sign on FLAIR images in Moyamoya disease and compare this finding with hemodynamic alterations on perfusion single-photon emission CT (SPECT) obtained before and after bypass surgery. Material and Methods: Sixteen patients with angiographically confirmed Moyamoya disease who underwent superficial temporal artery-middle cerebral artery (STA-MCA) anastomosis were included in the study. The presence of ivy sign on FLAIR images was classified as 'negative', 'minimal' and 'positive'. We evaluated the relationship between ivy sign and findings of SPECT, including cerebral vascular reserve (CVR) before and after surgery. Results: Minimal or positive ivy sign was seen in 13 (81%) of 16 patients, and 21 (66%) of 32 hemispheres. CVR in the areas with positive or minimal ivy sign was lower than that in the areas with negative ivy sign. After STA-MCA anastomosis, ivy sign disappeared or decreased in all 21 hemispheres demonstrating ivy sign. SPECT demonstrated apparent hemodynamic improvement in areas demonstrating disappearance or decrease of ivy sign. Conclusion: Ivy sign on FLAIR image is seen in areas with decreased cerebral perfusion. The sign is useful for non-invasive assessment of cerebral hemodynamic status before and after surgery

  8. Ivy signs on FLAIR images before and after STA-MCA anastomosis in patients with Moyamoya disease

    Background: Leptomeningeal high signal intensity (ivy sign) on fluid-attenuated inversion-recovery (FLAIR) MR imaging is one of the features of Moyamoya disease. However, the correlation between ivy sign and cerebral perfusion status has not been fully evaluated. Purpose: To characterize ivy sign on FLAIR images in Moyamoya disease and compare this finding with hemodynamic alterations on perfusion single-photon emission CT (SPECT) obtained before and after bypass surgery. Material and Methods: Sixteen patients with angiographically confirmed Moyamoya disease who underwent superficial temporal artery-middle cerebral artery (STA-MCA) anastomosis were included in the study. The presence of ivy sign on FLAIR images was classified as 'negative', 'minimal' and 'positive'. We evaluated the relationship between ivy sign and findings of SPECT, including cerebral vascular reserve (CVR) before and after surgery. Results: Minimal or positive ivy sign was seen in 13 (81%) of 16 patients, and 21 (66%) of 32 hemispheres. CVR in the areas with positive or minimal ivy sign was lower than that in the areas with negative ivy sign. After STA-MCA anastomosis, ivy sign disappeared or decreased in all 21 hemispheres demonstrating ivy sign. SPECT demonstrated apparent hemodynamic improvement in areas demonstrating disappearance or decrease of ivy sign. Conclusion: Ivy sign on FLAIR image is seen in areas with decreased cerebral perfusion. The sign is useful for non-invasive assessment of cerebral hemodynamic status before and after surgery

  9. Reconfigurability Analysis Method for Spacecraft Autonomous Control

    Dayi Wang

    2014-01-01

    Full Text Available As a critical requirement for spacecraft autonomous control, reconfigurability should be considered in design stage of spacecrafts by involving effective reconfigurability analysis method in guiding system designs. In this paper, a novel reconfigurability analysis method is proposed for spacecraft design. First, some basic definitions regarding spacecraft reconfigurability are given. Then, based on function tree theory, a reconfigurability modeling approach is established to properly describe system’s reconfigurability characteristics, and corresponding analysis procedure based on minimal cut set and minimal path set is further presented. In addition, indexes of fault reconfigurable degree and system reconfigurable rate for evaluating reconfigurability are defined, and the methodology for analyzing system’s week links is also constructed. Finally, the method is verified by a spacecraft attitude measuring system, and the results show that the presented method cannot only implement the quantitative reconfigurability evaluations but also find the weak links, and therefore provides significant improvements for spacecraft reconfigurability design.

  10. Application of dimensional analysis in systems modeling and control design

    Balaguer, Pedro

    2013-01-01

    Dimensional analysis is an engineering tool that is widely applied to numerous engineering problems, but has only recently been applied to control theory and problems such as identification and model reduction, robust control, adaptive control, and PID control. Application of Dimensional Analysis in Systems Modeling and Control Design provides an introduction to the fundamentals of dimensional analysis for control engineers, and shows how they can exploit the benefits of the technique to theoretical and practical control problems.

  11. Human reliability analysis of control room operators

    Santos, Isaac J.A.L.; Carvalho, Paulo Victor R.; Grecco, Claudio H.S. [Instituto de Engenharia Nuclear (IEN), Rio de Janeiro, RJ (Brazil)

    2005-07-01

    Human reliability is the probability that a person correctly performs some system required action in a required time period and performs no extraneous action that can degrade the system Human reliability analysis (HRA) is the analysis, prediction and evaluation of work-oriented human performance using some indices as human error likelihood and probability of task accomplishment. Significant progress has been made in the HRA field during the last years, mainly in nuclear area. Some first-generation HRA methods were developed, as THERP (Technique for human error rate prediction). Now, an array of called second-generation methods are emerging as alternatives, for instance ATHEANA (A Technique for human event analysis). The ergonomics approach has as tool the ergonomic work analysis. It focus on the study of operator's activities in physical and mental form, considering at the same time the observed characteristics of operator and the elements of the work environment as they are presented to and perceived by the operators. The aim of this paper is to propose a methodology to analyze the human reliability of the operators of industrial plant control room, using a framework that includes the approach used by ATHEANA, THERP and the work ergonomics analysis. (author)

  12. Large scale systems approximation: Analysis and control

    This work concerns the study of the approximation of high dimensional systems by low order models. This approximation is defined by aggregation methods, the method based on singular perturbations and a relatively recent method. This later one is formulated in a particular representation of the system and is called balanced realisation method. The application of the approximation is then studied in the case of suboptimal control theory for the several defined models. The results of numerical simulation for the analysis and control are carried on two examples defined by a model of a nuclear reactor core of order nine and a steam generator of a fuel station of order twenty and permitted to develop a comparative study of the performances of the different methods analysed in the case of open loop and closed loop models

  13. Controlling the accuracy of chemical analysis

    Most of the IAEA reference materials are certified in intercomparisons by calculation of the overall mean of reported laboratory mean values. IAEA certification is provided at ''A level'' (satisfactory, or high degree of confidence), or at ''B level'' (acceptable, or reasonable degree of confidence) sampling , storage and preliminary processing, use of reliable analytical methods, internal and external control of accuracy and reliability result in excellent certified reference materials for inorganic, geologic, environmental, biological and other quantitative analysis by means of conventional and nuclear methods. 34 refs, 4 figs, 3 tabs

  14. Coupling between the blood lactate-to-pyruvate ratio and MCA Vmean at the onset of exercise in humans

    Rasmussen, Peter; Madsen, Camilla A; Nielsen, Henning B; Zaar, Morten; Gjedde, Albert; Secher, Niels H; Quistorff, Bjørn

    2009-01-01

    Activation-induced increase in cerebral blood flow is coupled to enhanced metabolic activity, maybe with brain tissue redox state and oxygen tension as key modulators. To evaluate this hypothesis at the onset of exercise in humans, blood was sampled at 0.1 to 0.2 Hz from the radial artery and right...... oxygen tension decreased by 2.7 mmHg after 5 s (P < 0.05), while MCA V(mean) increased only after 30 s. Furthermore, there was an unaccounted cerebral carbohydrate uptake relative to the uptake of oxygen that became significant 50 s after the onset of exercise. These findings support brain tissue redox...... state and oxygenation as potential modulators of an increase in cerebral blood flow at the onset of exercise....

  15. Radioactivity analysis of food and accuracy control

    From the fact that radioactive substances have been detected from the foods such as agricultural and livestock products and marine products due to the accident of the Fukushima Daiichi Nuclear Power Station of Tokyo Electric Power Company, the Ministry of Health, Labour and Welfare stipulated new standards geared to general foods on radioactive cesium by replacing the interim standards up to now. Various institutions began to measure radioactivity on the basis of this instruction, but as a new challenge, a problem of the reliability of the data occurred. Therefore, accuracy control to indicate the proof that the quality of the data can be retained at an appropriate level judging from an objective manner is important. In order to consecutively implement quality management activities, it is necessary for each inspection agency to build an accuracy control system. This paper introduces support service, as a new attempt, for establishing the accuracy control system. This service is offered jointly by three organizations, such as TUV Rheinland Japan Ltd., Japan Frozen Foods Inspection Corporation, and Japan Chemical Analysis Center. This service consists of the training of radioactivity measurement practitioners, proficiency test for radioactive substance measurement, and personal authentication. (O.A.)

  16. Analysis and Design of Conventional Controller for Speed Control of DC Motor -A MATLAB Approach

    C. S. Linda; K. K.

    2015-01-01

    The objective of this paper is to control the speed of the motor using conventional controller; compensator is used to improve the steady state error. To evaluate the performance of the controller, time response analysis is carried out. The time response analysis consists of two type of analysis. One is unit step response analysis and other is performance indices analysis. The paper describes the designing of a closed loop model of the dc motor drive for controlling speed. Accurac...

  17. Improving Software Systems By Flow Control Analysis

    Piotr Poznanski

    2012-01-01

    Full Text Available Using agile methods during the implementation of the system that meets mission critical requirements can be a real challenge. The change in the system built of dozens or even hundreds of specialized devices with embedded software requires the cooperation of a large group of engineers. This article presents a solution that supports parallel work of groups of system analysts and software developers. Deployment of formal rules to the requirements written in natural language enables using formal analysis of artifacts being a bridge between software and system requirements. Formalism and textual form of requirements allowed the automatic generation of message flow graph for the (sub system, called the “big-picture-model”. Flow diagram analysis helped to avoid a large number of defects whose repair cost in extreme cases could undermine the legitimacy of agile methods in projects of this scale. Retrospectively, a reduction of technical debt was observed. Continuous analysis of the “big picture model” improves the control of the quality parameters of the software architecture. The article also tries to explain why the commercial platform based on UML modeling language may not be sufficient in projects of this complexity.

  18. An informal analysis of flight control tasks

    Andersen, George J.

    1991-01-01

    Issues important in rotorcraft flight control are discussed. A perceptual description is suggested of what is believed to be the major issues in flight control. When the task is considered of a pilot controlling a helicopter in flight, the task is decomposed in several subtasks. These subtasks include: (1) the control of altitude, (2) the control of speed, (3) the control of heading, (4) the control of orientation, (5) the control of flight over obstacles, and (6) the control of flight to specified positions in the world. The first four subtasks can be considered to be primary control tasks as they are not dependent on any other subtasks. However, the latter two subtasks can be considered hierarchical tasks as they are dependent on other subtasks. For example, the task of flight control over obstacles can be decomposed as a task requiring the control of speed, altitude, and heading. Thus, incorrect control of altitude should result in poor control of flight over an obstacle.

  19. Project evaluation, sustainability and accountability : combining cost-benefit analysis (CBA) and multi-criteria analysis (MCA)

    Sijtsma, F.J.

    2006-01-01

    General abstract Decision-makers in governments and businesses must choose among different project alternatives which, in varying degrees, contribute to sustainability. Decision-makers also have to account for their choices to a large audience or a broad range of stakeholders. This thesis is about t

  20. User controlled analysis of gamma ray spectra

    The program 'ANGES' was designed as a general purpose high-resolution γ ray spectrometry program. It offers all main features as commercial software packages except control of acquisition process. The program is able to perform automatic analysis of spectra but it is announced as 'user controlled' because it supplies all intermediate results and gives the opportunity these results to be analyzed and corrected by the user. ANGES offers: multi document Windows interface; detailed visualization of spectra; nuclide library based on another contribution to CRP; energy and FWHM calibrations calculated by means of orthonormal polynomial fitting; peak processing engine based on a non-linear LSQ method for fitting peaks; peak location engine, based on first derivative method is provided to ease the preparation of a spectrum for processing; two methods for efficiency calibration (an efficiency calibration curve and reference table); peak identification and activity calculation procedure; a number of corrections (true coincidence summing, background correction, pile up rejection and so on); an option for processing series of similar spectra. The fitting procedure can be applied to the whole spectrum or to a single Region-of-Interest (ROI). The assumed peak shape is pure Gaussian. All peaks in single ROI are assumed to have the same FWHM. The maximum number of peaks in a single ROI is restricted to 25, the maximum ROI length is 512 channels, and the baseline is described with a polynomial of a degree up to 4. As a result of the identification procedure a report file is issued containing spectrum processing results, list of identified and not identified peaks, list of identified nuclides and background nuclides. (author)

  1. Robustness analysis applied to substructure controller synthesis

    Gonzalez-Oberdoerffer, Marcelo F.; Craig, Roy R., Jr.

    1993-01-01

    The stability and robustness of the controlled system obtained via the substructure control synthesis (SCS) method of Su et al. (1990) were examined using a six-bay truss model, and employing an LQG control design method to obtain controllers for two separate structures. It is found that the assembled controller provides a stability in this instance. A qualitative assessment of the stability robustness of the system with controller designed with the SCS method is provided by obtaining a controller using the complete truss model and comparing the robustness of the corresponding closed-loop systems.

  2. Some chaotic behaviors in a MCA learning algorithm with a constant learning rate

    Douglas's minor component analysis algorithm with a constant learning rate has both stability and chaotic dynamical behavior under some conditions. The paper explores such dynamical behavior of this algorithm. Certain stability and chaos of this algorithm are derived. Waveform plots, Lyapunov exponents and bifurcation diagrams are presented to illustrate the existence of chaotic behavior

  3. Risk Analysis of Safety-Critical Control Systems

    Karol Rastocny

    2008-01-01

    This paper deals with problems associated with risks analysis of a safety-critical control system. In the paper there are introduced recommendations enabling practical enforceability of risk analysis by the assurance of sufficient objectivity level. In the initial phases of the system lifecycle risk analysis serves for a tolerable hazard rate definition for individual safety relevant functions. In the end of the control system development process the risk analysis (an analysis of failures con...

  4. Design and Simulation of Seido Buffer for Analog to Digital Converter (ADC) on Multichannel Analyzer (MCA) Application

    Most of our electronic equipment has buffer, thus this make buffer as one of importance in electronic gadget. This paper introduced Single Ended Input Differential Output (SEIDO) buffer to predict the bias at approximately 2.5 V. For this purpose, the input range between -1 mV to 4 V was implemented. The software used to cascade SEIDO buffer is called LTspice IV; an open source software developed by Linear Technology Incorporation. The component involve in this development was Operational Amplifier (OP AMP) AD826 from Analog Devices Incorporation, capacitor and resistor. Kirchhoffs Current Law and Kirchhoffs Voltage Law was applied to calculated voltage gain and biasing voltage. All design has been verified by LTspice IV. The result produced from simulation was between -0.3 V to 6.3 V with bias roughly at 2.5 V. These results prove that it was capable to drive Analog Digital Converter (ADC) that can subsequently apply for Multichannel Analyzer (MCA). (author)

  5. Sub-7-second genotyping of single-nucleotide polymorphism by high-resolution melting curve analysis on a thermal digital microfluidic device.

    Chen, Tianlan; Jia, Yanwei; Dong, Cheng; Gao, Jie; Mak, Pui-In; Martins, Rui P

    2016-02-21

    We developed a thermal digital microfluidic (T-DMF) device enabling ultrafast DNA melting curve analysis (MCA). Within 7 seconds, the T-DMF device succeeded in differentiating a melting point difference down to 1.6 °C with a variation of 0.3 °C in a tiny droplet sample (1.2 μL), which was 300 times faster and with 20 times less sample spending than the standard MCA (35 minutes, 25 μL) run in a commercial qPCR machine. Such a performance makes it possible for a rapid discrimination of single-nucleotide mutation relevant to prompt clinical decision-making. Also, aided by electronic intelligent control, the T-DMF device facilitates sample handling and pipelining in an automatic serial manner. An optimized oval-shaped thermal electrode is introduced to achieve high thermal uniformity. A device-sealing technique averts sample contamination and permits uninterrupted chemical/biological reactions. Simple fabrication using a single chromium layer fulfills both the thermal and typical transport electrode requirements. Capable of thermally modulating DNA samples with ultrafast MCA, this T-DMF device has the potential for a wide variety of life science analyses, especially for disease diagnosis and prognosis. PMID:26781669

  6. Logic reliability analysis of adaptive control strategies

    An approach is developed for the evaluation of the reliability of logic of adaptive control strategies, taking into account logic structural complexity and potential failure of programming modules. Flaws in the control system algorithm may not be discovered during debugging or initial testing and may only affect the performance under abnormal situations although the system may appear reliable in normal operations. Considering an adaptive control system designed for use in control of equipment employed in nuclear power stations, logic reliability evaluation is demonstrated. The approach given is applicable to any other designs and may be used to compare different control system logic structures from the reliability viewpoint. Evaluation of the reliability of control systems is essential to automated operation of equipment used in nuclear power plants. (author)

  7. Manufacturing control: A basis for analysis

    Bugg, N.

    1989-11-01

    The application of elementary control theory to manufacturing systems demonstrating how the organization of basic shop-floor logistics can be optimized prior to the introduction of computer technology is explored. A control structure is introduced and applied to manufacturing systems, breaking the problem into its constituent parts in such a way that the advantages of improved control technology become more apparent and more readily implementable.

  8. Explicit model predictive control accuracy analysis

    Knyazev, Andrew; Zhu, Peizhen; Di Cairano, Stefano

    2015-01-01

    Model Predictive Control (MPC) can efficiently control constrained systems in real-time applications. MPC feedback law for a linear system with linear inequality constraints can be explicitly computed off-line, which results in an off-line partition of the state space into non-overlapped convex regions, with affine control laws associated to each region of the partition. An actual implementation of this explicit MPC in low cost micro-controllers requires the data to be "quantized", i.e. repre...

  9. Technical specification for the vacuum chamber assemblies comprising flexible metal bellows, transition pieces, flanges and vacuum tubes for the magnets MCA/MCB in the experimental areas of the 450 GeV proton synchrotron

    CERN. Geneva

    1988-01-01

    Technical specification for the vacuum chamber assemblies comprising flexible metal bellows, transition pieces, flanges and vacuum tubes for the magnets MCA/MCB in the experimental areas of the 450 GeV proton synchrotron

  10. Flexible manipulator control experiments and analysis

    Yurkovich, S.; Ozguner, U.; Tzes, A.; Kotnik, P. T.

    1987-01-01

    Modeling and control design for flexible manipulators, both from an experimental and analytical viewpoint, are described. From the application perspective, an ongoing effort within the laboratory environment at the Ohio State University, where experimentation on a single link flexible arm is underway is described. Several unique features of this study are described here. First, the manipulator arm is slewed by a direct drive dc motor and has a rigid counterbalance appendage. Current experimentation is from two viewpoints: (1) rigid body slewing and vibration control via actuation with the hub motor, and (2) vibration suppression through the use of structure-mounted proof-mass actuation at the tip. Such an application to manipulator control is of interest particularly in design of space-based telerobotic control systems, but has received little attention to date. From an analytical viewpoint, parameter estimation techniques within the closed-loop for self-tuning adaptive control approaches are discussed. Also introduced is a control approach based on output feedback and frequency weighting to counteract effects of spillover in reduced-order model design. A model of the flexible manipulator based on experimental measurements is evaluated for such estimation and control approaches.

  11. Plasma membrane protein OsMCA1 is involved in regulation of hypo-osmotic shock-induced Ca2+ influx and modulates generation of reactive oxygen species in cultured rice cells

    Kurusu Takamitsu

    2012-01-01

    Full Text Available Abstract Background Mechanosensing and its downstream responses are speculated to involve sensory complexes containing Ca2+-permeable mechanosensitive channels. On recognizing osmotic signals, plant cells initiate activation of a widespread signal transduction network that induces second messengers and triggers inducible defense responses. Characteristic early signaling events include Ca2+ influx, protein phosphorylation and generation of reactive oxygen species (ROS. Pharmacological analyses show Ca2+ influx mediated by mechanosensitive Ca2+ channels to influence induction of osmotic signals, including ROS generation. However, molecular bases and regulatory mechanisms for early osmotic signaling events remain poorly elucidated. Results We here identified and investigated OsMCA1, the sole rice homolog of putative Ca2+-permeable mechanosensitive channels in Arabidopsis (MCAs. OsMCA1 was specifically localized at the plasma membrane. A promoter-reporter assay suggested that OsMCA1 mRNA is widely expressed in seed embryos, proximal and apical regions of shoots, and mesophyll cells of leaves and roots in rice. Ca2+ uptake was enhanced in OsMCA1-overexpressing suspension-cultured cells, suggesting that OsMCA1 is involved in Ca2+ influx across the plasma membrane. Hypo-osmotic shock-induced ROS generation mediated by NADPH oxidases was also enhanced in OsMCA1-overexpressing cells. We also generated and characterized OsMCA1-RNAi transgenic plants and cultured cells; OsMCA1-suppressed plants showed retarded growth and shortened rachises, while OsMCA1-suppressed cells carrying Ca2+-sensitive photoprotein aequorin showed partially impaired changes in cytosolic free Ca2+ concentration ([Ca2+]cyt induced by hypo-osmotic shock and trinitrophenol, an activator of mechanosensitive channels. Conclusions We have identified a sole MCA ortholog in the rice genome and developed both overexpression and suppression lines. Analyses of cultured cells with altered

  12. Control Engineering Analysis of Mechanical Pitch Systems

    With the help of a local stability analysis the coefficient range of a discrete damper, used for centrifugal forced, mechanical pitch system of small wind turbines (SWT), is gained for equilibrium points. – By a global stability analysis the gained coefficient range can be validated. An appropriate approach by Takagi-Sugeno is presented in the paper

  13. Set-Up of Digital MCA with HPGE Detector in High Gamma Fields

    The processing time adjustability of a commercial portable spectroscopy workstation based on Digital Signal Processing technology was investigated in areas from highly contaminated (mSv/h dose rate) to high energies (up to 8 MeV) to throughput and resolution performance coaxial Germanium detector. Altering the rise/fall and flat top times of the trapezoidal filter, it was estimated the full width at half maximum at the following peaks: 54Mn 834.8 keV, 60Co 1332.5 keV, 16O(n, p)16N 6129.9 keV, 56Fe(n, γ) 7631.1 keV and 56Fe(n, γ) 7645.5 keV. First type measurement for ultra-high counting and throughput rates was performed at ionex filter which capture activation products (54Mn, 60Co) from primary cooling medium and second type measurement for highest resolution was carried out at pressure water reactor platform during nominal power level giving high energy gamma 6129.9 keV from interaction fast neutrons 16O(n, p)16N and 7631.1 keV, 7645.5 keV from radiation capturing thermal neutrons by 56Fe(n, γ). To measure through energy range up to 8 MeV was reached setting coarse and fine gain to lower range and measuring at contaminated ionex filter by GBq activity was allowed using 50 mm cylindrical collimator by 30 mm diameter, without using this collimator was destroyed whole gamma spectrum despite altering rise/flat times. The results, which are presented, provide optimum performance for high throughput: FWHM 1.71 keV/834.8 keV (54Mn) and 2.00 keV/1332.5 keV (60Co) and best resolution: FWHM 4.49 keV/6129.9 keV (16N), 4.97 keV/7631.1 keV/7645.5 keV (prompt gamma iron) setting 2.8 μs rise time and 0.6 μs flat top time. For 0.8/1.2 μs rise time and 0.2 μs flat top time occurred results with destroyed resolution broadening and peak shift at 6129.9 keV and 7631.1/7645.5 keV. For rise time above 8.8 μs and flat time above 0.8 μs were peaks at 834.8 keV and 1332.5 keV unusable for purpose peak analysis process. (author)

  14. Analysis of inventory difference using fuzzy controllers

    The principal objectives of an accounting system for safeguarding nuclear materials are as follows: (a) to provide assurance that all material quantities are present in the correct amount; (b) to provide timely detection of material loss; and (c) to estimate the amount of any loss and its location. In fuzzy control, expert knowledge is encoded in the form of fuzzy rules, which describe recommended actions for different classes of situations represented by fuzzy sets. The concept of a fuzzy controller is applied to the forecasting problem in a time series, specifically, to forecasting and detecting anomalies in inventory differences. This paper reviews the basic notion underlying the fuzzy control systems and provides examples of application. The well-known material-unaccounted-for diffusion plant data of Jaech are analyzed using both feedforward neural networks and fuzzy controllers. By forming a deference between the forecasted and observed signals, an efficient method to detect small signals in background noise is implemented

  15. Adaptive Control Algorithms, Analysis and Applications

    Landau, Ioan; Lozano, Rogelio; M'Saad, Mohammed; Karimi, Alireza

    2011-01-01

    Adaptive Control (second edition) shows how a desired level of system performance can be maintained automatically and in real time, even when process or disturbance parameters are unknown and variable. It is a coherent exposition of the many aspects of this field, setting out the problems to be addressed and moving on to solutions, their practical significance and their application. Discrete-time aspects of adaptive control are emphasized to reflect the importance of digital computers in the ...

  16. Multichannel spectrum analysis for a gamma-ray imaging camera

    The US Department of Energy's robotics for nuclear reactors programs include the development of a gamma-ray imaging camera to locate and identify radiation fields typical of commercial reactor environments. The raster scanning camera is a lead-shielded bismuth germanate scintillator coupled to a photomultiplier tube operated in pulse mode. The camera is mounted on a rotating, tilting platform to allow two-dimensional scanning and requires a movable shutter to subtract background radiation. While previous work produced monochromatic images, this paper discusses colored images now available through a multichannel spectrum analysis at each pixel location, and typical images are shown. Scanning operation is controlled by a personal computer-based system with an independent multichannel analyzer (MCA) board that allows for near-real-time spectrum analysis of a pixel position while the following position is being measured. The controlling routine operates the camera tilt, rotation, and shutter movement; acquires data from the MCA; and calls the peak search analysis routine

  17. Controllability Analysis for Multirotor Helicopter Rotor Degradation and Failure

    Du, Guang-Xun; Quan, Quan; Yang, Binxian; Cai, Kai-Yuan

    2015-05-01

    This paper considers the controllability analysis problem for a class of multirotor systems subject to rotor failure/wear. It is shown that classical controllability theories of linear systems are not sufficient to test the controllability of the considered multirotors. Owing to this, an easy-to-use measurement index is introduced to assess the available control authority. Based on it, a new necessary and sufficient condition for the controllability of multirotors is derived. Furthermore, a controllability test procedure is approached. The proposed controllability test method is applied to a class of hexacopters with different rotor configurations and different rotor efficiency parameters to show its effectiveness. The analysis results show that hexacopters with different rotor configurations have different fault-tolerant capabilities. It is therefore necessary to test the controllability of the multirotors before any fault-tolerant control strategies are employed.

  18. Nonlinear analysis and control of a continuous fermentation process

    Szederkényi, G.; Kristensen, Niels Rode; Hangos, K.M;

    2002-01-01

    Different types of nonlinear controllers are designed and compared for a simple continuous bioreactor operating near optimal productivity. This operating point is located close to a fold bifurcation point. Nonlinear analysis of stability, controllability and zero dynamics is used to investigate...... open-loop system properties, to explore the possible control difficulties and to select the system output to be used in the control structure. A wide range of controllers are tested including pole placement and LQ controllers, feedback and input–output linearization controllers and a nonlinear...

  19. A new microcomputer-controlled neutron activation and analysis system

    A microcomputer-controlled irradiation and measurement system and a microprocessor-controlled sample changer have been installed at the SLOWPOKE-2 Facility at the Royal Military College of Canada (RMC). These systems can provide the gamut of instrumental neutron activation analysis (INAA) techniques for the analyst. Custom software has been created for system control, data acquisition, and off-line spectral analysis using programs that incorporate Gaussian peak-fitting methods of analysis. The design and use of the equipment is discussed, and the performance is illustrated with results obtained from the analysis of marine sediment and biological reference materials

  20. 21 CFR 123.6 - Hazard analysis and Hazard Analysis Critical Control Point (HACCP) plan.

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Hazard analysis and Hazard Analysis Critical... Provisions § 123.6 Hazard analysis and Hazard Analysis Critical Control Point (HACCP) plan. (a) Hazard analysis. Every processor shall conduct, or have conducted for it, a hazard analysis to determine...

  1. CSADP, a classical control system analysis and design package

    Couture, Scott A.

    1985-01-01

    The Control System Analysis and Design Package (CSADP) is a computer-aided design package for applying classical control system analysis and design tools to experimental frequency response measurements. CSADP allows the user to analyze and manipulate measured frequency response data, design control systems using these measurements, and determine the operational amplifier hardware required to implement the design. To perform these tasks, CSADP provides tools that allow the us...

  2. Damping torque analysis for DC bus implemented damping control

    W. Du; WANG, HAIFENG; Ju, P.; Dunn, R

    2010-01-01

    Damping torque analysis is a well-developed technique for understanding and studying power system oscillations. This paper presents the applications of damping torque analysis for DC bus implemented damping control in power transmission networks in two examples. The first example is the investigation of damping effect of shunt VSC (Voltage Source Converter) based FACTS voltage control, i.e., STATCOM (Static Synchronous Compensator) voltage control. It is shown in the paper that STATCOM voltag...

  3. INTERNAL AUDIT COMPARATIVE ANALYSIS - MANAGEMENT CONTROL CONCEPTS

    MIHAI-DOREL JURCHESCU

    2010-01-01

    Full Text Available Given Romania's integration into the European Union we consider it appropriate to clarify some terms used in auditing activities of both public funds and European funds. International practice requires a clear separation of internal audit activities from other management control concepts and recommend to establish an internal controlling system as well as an internal audit structure under the coordination of the manager as being the only ways cap able to respond to current risks faced by public entities. Internal Audit, along its evolution - characterized by complex dynamics and adaptability - created confusion regarding the concept of control. The research presented in this paper is based on works published to date regarding the conceptual boundaries of this notion.

  4. An analysis of safety control effectiveness

    The cost of injuries and 'accidents' to an organisation is very important in establishing how much it should spend on safety control. Despite the usefulness of information about the cost of a company's accidents, it is not customary accounting practice to make these data available. Of the two kinds of costs incurred by a company through occupational injuries and accidents, direct costs and indirect costs; the direct costs are much easier to estimate. However, the uninsured costs are usually more critical and should be estimated by each company. The authors investigate a general model to estimate the above costs and hence to establish efficient safety control. One construction company has been a pilot for this study. By analysing actual company data for three years, it is found that the efficient safety control cost should be 1.2-1.3% of total contract costs

  5. Solar Dynamic Power System Stability Analysis and Control

    Momoh, James A.; Wang, Yanchun

    1996-01-01

    The objective of this research is to conduct dynamic analysis, control design, and control performance test of solar power system. Solar power system consists of generation system and distribution network system. A bench mark system is used in this research, which includes a generator with excitation system and governor, an ac/dc converter, six DDCU's and forty-eight loads. A detailed model is used for modeling generator. Excitation system is represented by a third order model. DDCU is represented by a seventh order system. The load is modeled by the combination of constant power and constant impedance. Eigen-analysis and eigen-sensitivity analysis are used for system dynamic analysis. The effects of excitation system, governor, ac/dc converter control, and the type of load on system stability are discussed. In order to improve system transient stability, nonlinear ac/dc converter control is introduced. The direct linearization method is used for control design. The dynamic analysis results show that these controls affect system stability in different ways. The parameter coordination of controllers are recommended based on the dynamic analysis. It is concluded from the present studies that system stability is improved by the coordination of control parameters and the nonlinear ac/dc converter control stabilize system oscillation caused by the load change and system fault efficiently.

  6. HIV control in vivo: Dynamical analysis

    Gumel, A. B.; Moghadas, S. M.

    2004-10-01

    A deterministic model for the immunological and therapeutic control of human immunodeficiency virus (HIV) in vivo is studied qualitatively. In addition to analyzing the local stability of the equilibria, the global stability of the infection-free equilibrium is established. The optimal efficacy level of anti-retroviral therapy needed to eradicate HIV from the body of an HIV-infected individual is obtained.

  7. Analysis of Reconfigured Control Loop with a Virtual Actuator

    Anna Filasova

    2011-01-01

    Full Text Available Control reconfiguration changes the control structure in response to a fault detected in the plant. This becomes necessary, because a major fault like loss of an actuator breaks the corresponding control loop and therefore renders the whole system inoperable.  An important aim of control reconfiguration is to change the control structure as little as possible, since every change bears the potential of practical problems. The proposed solution is to keep the original controller in the loop and to add an extension called virtual actuator that implements the necessary changes of the control structure. The virtual actuator translates between the signals of the nominal controller and the signal of the faulty plants. This paper is concerned with the analysis of reconfigured loop with a virtual actuator for the system with the faulty actuator. The proposed analysis is illustrated on numerical example.

  8. Time Series Analysis Forecasting and Control

    Box, George E P; Reinsel, Gregory C

    2011-01-01

    A modernized new edition of one of the most trusted books on time series analysis. Since publication of the first edition in 1970, Time Series Analysis has served as one of the most influential and prominent works on the subject. This new edition maintains its balanced presentation of the tools for modeling and analyzing time series and also introduces the latest developments that have occurred n the field over the past decade through applications from areas such as business, finance, and engineering. The Fourth Edition provides a clearly written exploration of the key methods for building, cl

  9. Space Station Environment Control and Life Support System Pressure Control Pump Assembly Modeling and Analysis

    Schunk, R. Gregory

    2002-01-01

    This paper presents the Modeling and Analysis of the Space Station Environment Control and Life Support System Pressure Control Pump Assembly (PCPA). The contents include: 1) Integrated PCPA/Manifold Analyses; 2) Manifold Performance Analysis; 3) PCPA Motor Heat Leak Study; and 4) Future Plans. This paper is presented in viewgraph form.

  10. Welfare Analysis of Pollution Control With Spatial Alternatives

    Vinod Thomas

    1983-01-01

    This paper deals with the welfare losses resulting from emission control policies which do not take into account differences in control costs among firms and in benefits across regions. In contrast, an optimal policy considers these differences, and on their basis, requires differential controls among regions, presumably encouraging spatial adaptation of production. Drawing on an empirical analysis of welfare benefits and welfare costs of controlling particulate emissions from the iron and st...

  11. Analysis and Comparison of Access Control Policies Validation Mechanisms

    Muhammad Aqib; Riaz Ahmed Shaikh

    2014-01-01

    Validation and verification of security policies is a critical and important task to ensure that access control policies are error free. The two most common problems present in access control policies are: inconsistencies and incompleteness. In order to detect such problems, various access control policy validation mechanisms are proposed by the researchers. However, comprehensive analysis and evaluation of the existing access control policy validation techniques is missing in the literature....

  12. Analysis of the Body Control System Related to Mental Workload

    Seiji Naito; Youngwoo Kim; Goro Obinata

    2012-01-01

    In this paper, we present a model‐based analysis of the standing posture control mechanism with consideration to mental workload and the physiological features of sensory feedback. It has been known that standing posture control is not performed autonomously or unconsciously but is affected by “working memory” [1]. In order to investigate how mental workload in working memory influences standing posture control, we consider the feedback groups in the standing posture control mechanism which i...

  13. Spacecraft attitude control momentum requirements analysis

    Robertson, Brent P.; Heck, Michael L.

    1987-01-01

    The relationship between attitude and angular momentum control requirements is derived for a fixed attitude, Earth orbiting spacecraft with large area articulating appendages. Environmental effects such as gravity gradient, solar radiation pressure, and aerodynamic forces arising from a dynamic, rotating atmosphere are examined. It is shown that, in general, each environmental effect contributes to both cyclic and secular momentum requirements both within and perpendicular to the orbit plane. The gyroscopic contribution to the angular momentum control requirements resulting from a rotating, Earth oriented spacecraft is also discussed. Special conditions are described where one or more components of the angular momentum can be made to vanish, or become purely cyclical. Computer generated plots for a candidate space station configuration are presented to supplement the analytically derived results.

  14. Pushdown Control-Flow Analysis of Higher-Order Programs

    Earl, Christopher; Van Horn, David

    2010-01-01

    Context-free approaches to static analysis gain precision over classical approaches by perfectly matching returns to call sites---a property that eliminates spurious interprocedural paths. Vardoulakis and Shivers's recent formulation of CFA2 showed that it is possible (if expensive) to apply context-free methods to higher-order languages and gain the same boost in precision achieved over first-order programs. To this young body of work on context-free analysis of higher-order programs, we contribute a pushdown control-flow analysis framework, which we derive as an abstract interpretation of a CESK machine with an unbounded stack. One instantiation of this framework marks the first polyvariant pushdown analysis of higher-order programs; another marks the first polynomial-time analysis. In the end, we arrive at a framework for control-flow analysis that can efficiently compute pushdown generalizations of classical control-flow analyses.

  15. The Importance of Variance Analysis for Costs Control in Organizations

    Okoh, L. O.; Uzoka, P.

    2012-01-01

    This review aimed at examining the importance of variance analysis for cost control in organizations. The study x-rayed the concept of variance analysis, types, sources, objectives and its significance. The study reported that variance analysis has significant influence in evaluating individual performance in organizations, assignment of responsibilities to individuals and assisting management to rely on the principle of management by exception and recommended among others, variances analysis...

  16. Analysis and decoupling control of a permanent magnet spherical actuator

    Zhang, Liang; Chen, Weihai; Liu, Jingmeng; Wu, Xingming

    2013-12-01

    This paper presents the analysis and decoupling control of a spherical actuator, which is capable of performing three degree-of-freedom motion in one joint. The proposed actuator consists of a rotor with multiple PM (Permanent Magnet) poles in a circle and a stator with circumferential coils in three layers. Based on this actuator design, a decoupling control approach is developed. Unlike existing control methods that each coil is responsible for both the spinning and tilting motion, the proposed control strategy specifies the function of each coil. Specifically, the spinning motion is governed by the middle layer coils with a step control approach; while the tilting motion is regulated by upper and lower coils with a computed torque control method. Experiments have been conducted on the prototype to verify the validity of the design procedure, and the experimental results demonstrate the effectiveness of the analysis and control strategy.

  17. Complexity, Analysis and Control of Singular Biological Systems

    Zhang, Qingling; Zhang, Xue

    2012-01-01

    Complexity, Analysis and Control of Singular Biological Systems follows the control of real-world biological systems at both ecological and phyisological levels concentrating on the application of now-extensively-investigated singular system theory. Much effort has recently been dedicated to the modelling and analysis of developing bioeconomic systems and the text establishes singular examples of these, showing how proper control can help to maintain sustainable economic development of biological resources. The book begins from the essentials of singular systems theory and bifurcations before tackling  the use of various forms of control in singular biological systems using examples including predator-prey relationships and viral vaccination and quarantine control. Researchers and graduate students studying the control of complex biological systems are shown how a variety of methods can be brought to bear and practitioners working with the economics of biological systems and their control will also find the ...

  18. Controllability analysis of modified Petlyuk structures

    Tamayo-Galvan, V.E.; Segovia-Hernandez, J.G.; Hernandez, S.; Hernandez, H. [Guanajuato Univ. (Mexico). Faculty of Chemistry

    2008-02-15

    Distillation columns can consume a large portion of energy in chemical industry processes. Integrated Petlyuk columns have been shown to improve energy efficiencies by between 20 and 40 per cent, and thermally coupled distillation columns can serve as an alternative to conventional distillation sequences in multicomponent mixture separation processes. Until recently, operational difficulties have limited the wider introduction of Petlyuk columns in industrial applications. Alternative Petlyuk-type schemes have now been developed to provide improved operation properties. This paper discussed, evaluated, and compared the theoretical control properties of 6 different Petlyuk schemes. Computations were performed using a singular value decomposition (SVD) technique in the frequency domain. Dynamic closed-loop responses for set point tracking, and disturbance rejections were derived in order to support each scheme's theoretical control properties. Results of the comparative evaluation demonstrated that reductions in the number of interconnections and the use of unidirectional flows impacted the dynamic properties of the schemes, and led to operational improvements in thermally coupled distillation sequences. It was concluded that Petyluk properties can be improved through the correction of the bidirectionality of interconnecting streams. 30 refs., 10 tabs., 9 figs.

  19. Analysis and design of networked control systems

    You, Keyou; Xie, Lihua

    2015-01-01

    This monograph focuses on characterizing the stability and performance consequences of inserting limited-capacity communication networks within a control loop. The text shows how integration of the ideas of control and estimation with those of communication and information theory can be used to provide important insights concerning several fundamental problems such as: ·         minimum data rate for stabilization of linear systems over noisy channels; ·         minimum network requirement for stabilization of linear systems over fading channels; and ·         stability of Kalman filtering with intermittent observations. A fundamental link is revealed between the topological entropy of linear dynamical systems and the capacities of communication channels. The design of a logarithmic quantizer for the stabilization of linear systems under various network environments is also extensively discussed and solutions to many problems of Kalman filtering with intermittent observations are de...

  20. Discrete Mechanics and Optimal Control: an Analysis

    Ober-Bloebaum, S; Marsden, J E

    2008-01-01

    The optimal control of a mechanical system is of crucial importance in many realms. Typical examples are the determination of a time-minimal path in vehicle dynamics, a minimal energy trajectory in space mission design, or optimal motion sequences in robotics and biomechanics. In most cases, some sort of discretization of the original, infinite-dimensional optimization problem has to be performed in order to make the problem amenable to computations. The approach proposed in this paper is to directly discretize the variational description of the system's motion. The resulting optimization algorithm lets the discrete solution directly inherit characteristic structural properties from the continuous one like symmetries and integrals of the motion. We show that the DMOC approach is equivalent to a finite difference discretization of Hamilton's equations by a symplectic partitioned Runge-Kutta scheme and employ this fact in order to give a proof of convergence. The numerical performance of DMOC and its relationsh...

  1. Modeling and Analysis of PI Controller Based Speed Control of Brushless DC Motor Drive.

    Mr.P.Nagasekhar Reddy

    2013-09-01

    Full Text Available The Brushless DC motors (BLDC find widespread applications in domestic and industries due to their low and high power density and ease of speed control. To accomplish desired level of performance the motor requires suitable speed controllers. In case of permanent magnet Brushless DC motors, usually control of speed is reached by using proportional integral (PI controller. Although the conventional PI controllers are widely used in the industry due to their simple control structure and ease of implementation, these controllers pose difficulties where there are some control complexity such as nonlinearity, load disturbances and parametric variations. Moreover PI controllers require precise linear mathematical models. In this paper, the analysis and mathematical modeling of BLDC motor is implemented. Also, speed control of three phase BLDC motor drive using power electronic device is projected by using matlab/Simulink. The simulation result shows the improved performance of developed Brushless DC motor drive.

  2. Effects of chemical carcinogens on hemopoiesis, immunopoiesis and viral oncogenesis. Three year technical progress report, February 1, 1977-September 30, 1979. [MMS; BP; DMBA; propane sultone; MCA; mice

    OKunewick, J.P.; Raikow, R.B.; Meredith, R.F.

    1979-09-01

    Studies were initiated to evaluate in an in vitro system selected chemical carcinogens derived from energy producing hydrocarbons for their effect on the hematopoietic and immune systems. Studies were also conducted to determine whether the selected carcinogens could interact with leukemogenic virus to produce leukemia in mice. Five compounds have been investigated thus far: (1) methylmethane sulfonate (MMS); (2) benzo(a)pyrene (BP); (3) 7,12 dimethylbenz(a)anthracene (DMBA); (4) propane sultone (PS); and (5) 20-methylcholanthrene (MCA). MMS inhibited both the colony forming ability of CFU-S and the immune response of PFC. MMS also potentiated the development of Friend viral leukemia when given to mice before the virus. The observed potentiation did not appear to correlate with the suppressed antibody formation response of the PFC. Good temporal correlation was found between leukemia potentiation and suppression of the colony forming ability of the CFU-S. DNA synthetic activity was also increased without a substantial increase in the number of CFU-S over that found for normal mice. BP also inhibited colony forming by the CFU-S. Effects of BP on PFC response were of a mixed nature, varying as a function of time. When given in conjunction with Friend leukemia virus, a potentiation of leukemia development was observed. To date no suppressive effect of DMBA on PFC response has been observed. The results on potentiation of viral leukemogenesis are also varied. With a high virus dose, DMBA inhibited leukemia development. However, when a subthreshold dose of virus was employed, injections of DMBA resulted in potentiation. Studies with MCA and PS were only recently begun. The effects of PS on PFC response were measured at selected dates. Suppression was found only at one time. Initial data suggests that MCA may potentiate the development of viral leukemogenesis when given before the virus. (ERB)

  3. Proposed design for a high quality PC-MCA add on card with reduced electronic hardware [Paper No.: I4

    This paper describes the design and construction of an 8 k personal computer analyser (PCA), used for nuclear pulse height analysis. The complete PCA uses a single card that can be mounted in a slot of personal computer. The PCA circuit consists of an interface memory circuit and an 8-K nuclear ADC along with its associated controls giving differential non-linearity (DNL) of ≤ ± 1% with conversion time of nearly 15 micro sec. All standard facilities like selection of conversion gain, digital offset etc. are provided. (author). 3 refs., 2 figs

  4. Analysis and Design of Conventional Controller for Speed Control of DC Motor -A MATLAB Approach

    C. S. Linda

    2015-02-01

    Full Text Available The objective of this paper is to control the speed of the motor using conventional controller; compensator is used to improve the steady state error. To evaluate the performance of the controller, time response analysis is carried out. The time response analysis consists of two type of analysis. One is unit step response analysis and other is performance indices analysis. The paper describes the designing of a closed loop model of the dc motor drive for controlling speed. Accuracy and the dynamic responses are better in a closed loop system. The compensator is used to compensate the parameter of the system in such a way to meet the specification, so that it improves the steady state response of the system and get desired response.

  5. Supercritical carbon dioxide cycle control analysis.

    Moisseytsev, A.; Sienicki, J. J. (Nuclear Engineering Division)

    2011-04-11

    This report documents work carried out during FY 2008 on further investigation of control strategies for supercritical carbon dioxide (S-CO{sub 2}) Brayton cycle energy converters. The main focus of the present work has been on investigation of the S-CO{sub 2} cycle control and behavior under conditions not covered by previous work. An important scenario which has not been previously calculated involves cycle operation for a Sodium-Cooled Fast Reactor (SFR) following a reactor scram event and the transition to the primary coolant natural circulation and decay heat removal. The Argonne National Laboratory (ANL) Plant Dynamics Code has been applied to investigate the dynamic behavior of the 96 MWe (250 MWt) Advanced Burner Test Reactor (ABTR) S-CO{sub 2} Brayton cycle following scram. The timescale for the primary sodium flowrate to coast down and the transition to natural circulation to occur was calculated with the SAS4A/SASSYS-1 computer code and found to be about 400 seconds. It is assumed that after this time, decay heat is removed by the normal ABTR shutdown heat removal system incorporating a dedicated shutdown heat removal S-CO{sub 2} pump and cooler. The ANL Plant Dynamics Code configured for the Small Secure Transportable Autonomous Reactor (SSTAR) Lead-Cooled Fast Reactor (LFR) was utilized to model the S-CO{sub 2} Brayton cycle with a decaying liquid metal coolant flow to the Pb-to-CO{sub 2} heat exchangers and temperatures reflecting the decaying core power and heat removal by the cycle. The results obtained in this manner are approximate but indicative of the cycle transient performance. The ANL Plant Dynamics Code calculations show that the S-CO{sub 2} cycle can operate for about 400 seconds following the reactor scram driven by the thermal energy stored in the reactor structures and coolant such that heat removal from the reactor exceeds the decay heat generation. Based on the results, requirements for the shutdown heat removal system may be defined

  6. Supercritical carbon dioxide cycle control analysis

    This report documents work carried out during FY 2008 on further investigation of control strategies for supercritical carbon dioxide (S-CO2) Brayton cycle energy converters. The main focus of the present work has been on investigation of the S-CO2 cycle control and behavior under conditions not covered by previous work. An important scenario which has not been previously calculated involves cycle operation for a Sodium-Cooled Fast Reactor (SFR) following a reactor scram event and the transition to the primary coolant natural circulation and decay heat removal. The Argonne National Laboratory (ANL) Plant Dynamics Code has been applied to investigate the dynamic behavior of the 96 MWe (250 MWt) Advanced Burner Test Reactor (ABTR) S-CO2 Brayton cycle following scram. The timescale for the primary sodium flowrate to coast down and the transition to natural circulation to occur was calculated with the SAS4A/SASSYS-1 computer code and found to be about 400 seconds. It is assumed that after this time, decay heat is removed by the normal ABTR shutdown heat removal system incorporating a dedicated shutdown heat removal S-CO2 pump and cooler. The ANL Plant Dynamics Code configured for the Small Secure Transportable Autonomous Reactor (SSTAR) Lead-Cooled Fast Reactor (LFR) was utilized to model the S-CO2 Brayton cycle with a decaying liquid metal coolant flow to the Pb-to-CO2 heat exchangers and temperatures reflecting the decaying core power and heat removal by the cycle. The results obtained in this manner are approximate but indicative of the cycle transient performance. The ANL Plant Dynamics Code calculations show that the S-CO2 cycle can operate for about 400 seconds following the reactor scram driven by the thermal energy stored in the reactor structures and coolant such that heat removal from the reactor exceeds the decay heat generation. Based on the results, requirements for the shutdown heat removal system may be defined. In particular, the peak heat removal

  7. Radial Clearance Control and Internal Leakage Analysis of a Tri-Proportion Controller

    LI Dai-jin; ZHANG Yu-wen; TANG Hao; DANG Jian-jun; LUO Kai

    2009-01-01

    The tri-propellant thermal propulsion system is one of the hottest subjects in the.field of underwater vehicles recently. To improve efficiency of underwater vehicles, a method of radial clearance control of the tri-proportion has been proposed. Based on analyzing the factors which influence the pressure decrease and leakage of the tri-proportion controller, a method is used for precision analysis and proportion adjustment by using the median optimizing theory. Analysis results show that accuracy of the proportion controller is dependent on all the leakage, while the leakage is decided by radial clearance and pressure; the leakage can be controlled effectively and the accuracy of the proportion can be improved with the radial clearance control method. The method of accuracy analysis and clearance control has value on the design of various hydraulic motors.

  8. Analysis and Design of PLL Motor Speed Control System

    Qi Chao Zhang

    2013-10-01

    Full Text Available Phase-locked technology in motor speed control system has a wide range of applications, Especially for high accuracy in the motor steady speed operation situation, more and more use of phase-locked servo control system. This paper describes the block diagram and mathematical model of phase-locked control system, Shows the circuit parameter calculation method This and combined with design example analysis of phase-locked control system, Indicated through the theory and practice, using PLL can obtain good speed control precision.

  9. Team One (GA/MCA) effort of the DOE 12 Tesla Coil Development Program. Progress report for the two quarters ending March 31, 1981

    This report covers progress by Team One of the DOE/OFE/D and T 12 Tesla Coil Development Program during the first and second quarters of fiscal 1981. General Atomic Company is the Team One leader, with Magnetic Corporation of America (MCA) as industrial subcontractor. The basic mission of this effort is to demonstrate the feasibility of, and establish an engineering data base for utilizing bath cooled NbTi alloy to generate a peak toroidal field of 12 tesla in a tokamak reactor

  10. Power flow analysis for DC voltage droop controlled DC microgrids

    Li, Chendan; Chaudhary, Sanjay; Dragicevic, Tomislav;

    2014-01-01

    carried out by comparing the calculation results with detailed time domain simulation results. With the droop parameters as variables in the power flow analysis, their effects on power sharing and secondary voltage regulation can now be analytically studied, and specialized optimization in the upper level......This paper proposes a new algorithm for power flow analysis in droop controlled DC microgrids. By considering the droop control in the power flow analysis for the DC microgrid, when compared with traditional methods, more accurate analysis results can be obtained. The algorithm verification is...... control can also be made accordingly. Case studies on power sharing and secondary voltage regulation are carried out using proposed power flow analysis....

  11. Aircraft Accident Prevention: Loss-of-Control Analysis

    Kwatny, Harry G.; Dongmo, Jean-Etienne T.; Chang, Bor-Chin; Bajpai, Guarav; Yasar, Murat; Belcastro, Christine M.

    2009-01-01

    The majority of fatal aircraft accidents are associated with loss-of-control . Yet the notion of loss-of-control is not well-defined in terms suitable for rigorous control systems analysis. Loss-of-control is generally associated with flight outside of the normal flight envelope, with nonlinear influences, and with an inability of the pilot to control the aircraft. The two primary sources of nonlinearity are the intrinsic nonlinear dynamics of the aircraft and the state and control constraints within which the aircraft must operate. In this paper we examine how these nonlinearities affect the ability to control the aircraft and how they may contribute to loss-of-control. Examples are provided using NASA s Generic Transport Model.

  12. Regulatory control analysis and design for sewer systems

    Mollerup, Ane Loft; Mikkelsen, Peter Steen; Thornberg, Dines;

    2015-01-01

    case study area of Copenhagen. The analysis effectively reduces the number of potential controlled variables, by considering the sensitivity of the measurements towards changes in the manipulated variables. Several potential pairings are generated and the best alternative is chosen for closed......-loop testing. The methodology is a promising tool for systematic generation of solutions for sewer system control....

  13. Updated Meta-Analysis of Learner Control within Educational Technology

    Karich, Abbey C.; Burns, Matthew K.; Maki, Kathrin E.

    2014-01-01

    Giving a student control over their learning has theoretical and intuitive appeal, but its effects are neither powerful nor consistent in the empirical literature base. This meta-analysis updated previous meta-analytic research by Niemiec, Sikorski, and Walberg by studying the overall effectiveness of providing learner control within educational…

  14. Analysis of design control values for TEP

    The Tokamak Exhaust Processing (TEP) Performance Requirements Report (USITER-13201-TD0005-R00), date May 29, 2007 defined feed sources for TEP quantities and approximate flow rate of gases from these individual sources. In addition, the report identified the approximate periods of time (during Burn and Dwell, 'Silent Shift', etc.) that these gases would be transferred to TEP. This report did not take into account the detailed, time dependent, sequencing options for receiving gases from these feed sources. Sequencing is critical in defining the actual design basis values (flow rates, etc.) for TEP. This report analyzes the time dependent sequencing of feed flows to TEP and defines the ,design basis values. This analysis is based on the values presented in the TEP Performance Requirements Report (TEP PRR), and indicates that the ITER Burn and Dwell, Silent Shift Following 16 hours of Burn and Dwell, Glow Discharge Cleaning (GDC), and Silent Shift following 100 hours of GDC scenarios are the limiting scenarios from which the design basis values will be defined.

  15. Manual-control Analysis Applied to the Money-supply Control Task

    Wingrove, R. C.

    1984-01-01

    The recent procedure implemented by the Federal Reserve Board to control the money supply is formulated in the form of a tracking model as used in the study of manual-control tasks. Using this model, an analysis is made to determine the effect of monetary control on the fluctuations in economic output. The results indicate that monetary control can reduce the amplitude of fluctuations at frequencies near the region of historic business cycles. However, with significant time lags in the control loop, monetary control tends to increase the amplitude of the fluctuations at the higher frequencies. How the investigator or student can use the tools developed in the field of manual-control analysis to study the nature of economic fluctuations and to examine different strategies for stabilization is examined.

  16. Analysis of supplementary controls in damping subsynchronous oscillations

    Balasubramanyam, P.V.; Murty, A.S.R.; Sarkar, B.N. [Central Power Research Inst., Bangalore (India). Central Research and Testing Lab.

    1995-12-31

    Analysis and damping of torsional oscillations through thyristor control reactor (TCR) is presented in this paper. The reactive power control is achieved through TCR at the machine terminals. Generator speed deviation signal is used as auxiliary signal and terminal voltage feed back signal as main control signal for TCR. The following control strategies for auxiliary control to TCR have been analyzed. Case 1: Analysis of basic system without damping controls. Case 2: Proportional control (P). Case 3: Proportional control with filter (P+filter). Case 4: Proportional plus derivative control with filter (P+D+filter). Case 5: Proportional plus integral plus derivative control with filter (P+I+D+filter). The main objective of this paper is to discuss the performance of different control strategies for damping torsional oscillations when a generator is connected to an infinite bus via double circuit 400kV transmission line, in which one circuit is series compensated. This configuration is similar to IEEE benchmark two model.

  17. Power system small signal stability analysis and control

    Mondal, Debasish; Sengupta, Aparajita

    2014-01-01

    Power System Small Signal Stability Analysis and Control presents a detailed analysis of the problem of severe outages due to the sustained growth of small signal oscillations in modern interconnected power systems. The ever-expanding nature of power systems and the rapid upgrade to smart grid technologies call for the implementation of robust and optimal controls. Power systems that are forced to operate close to their stability limit have resulted in the use of control devices by utility companies to improve the performance of the transmission system against commonly occurring power system

  18. Integration of Design and Control through Model Analysis

    Russel, Boris Mariboe; Henriksen, Jens Peter; Jørgensen, Sten Bay;

    2002-01-01

    and design (manipulative) variables that may be employed with different objectives in design and control for the integrated problem. The computer aided model analysis is highlighted through illustrative examples, involving processes with mass and/or energy recycle, where the important design and...... representing the constitutive equations identify the relationships between the important process and design variables, which help to understand, define and address some of the issues related to integration of design and control. Furthermore, the analysis is able to identify a set of process (control) variables...

  19. Certification, accreditation, and quality control in behavior analysis

    Moore, J.; Shook, G L

    2001-01-01

    Implementing quality control measures in the discipline and professional practice of behavior analysis is a challenging, but nevertheless important, step in the evolution of our field. The Association for Behavior Analysis currently seeks to ensure quality in behavior analysis by sponsoring an accreditation program for graduate academic programs and by promoting certification of individual practitioners. The accreditation reviews are conducted by ABA, whereas certification status is awarded b...

  20. Stability Analysis for Car Following Model Based on Control Theory

    Stability analysis is one of the key issues in car-following theory. The stability analysis with Lyapunov function for the two velocity difference car-following model (for short, TVDM) is conducted and the control method to suppress traffic congestion is introduced. Numerical simulations are given and results are consistent with the theoretical analysis. (electromagnetism, optics, acoustics, heat transfer, classical mechanics, and fluid dynamics)

  1. Ribonucleoprotein particles of bacterial small non-coding RNA IsrA (IS61 or McaS) and its interaction with RNA polymerase core may link transcription to mRNA fate.

    van Nues, Rob W; Castro-Roa, Daniel; Yuzenkova, Yulia; Zenkin, Nikolay

    2016-04-01

    Coupled transcription and translation in bacteria are tightly regulated. Some small RNAs (sRNAs) control aspects of this coupling by modifying ribosome access or inducing degradation of the message. Here, we show that sRNA IsrA (IS61 or McaS) specifically associates with core enzyme of RNAPin vivoandin vitro, independently of σ factor and away from the main nucleic-acids-binding channel of RNAP. We also show that, in the cells, IsrA exists as ribonucleoprotein particles (sRNPs), which involve a defined set of proteins including Hfq, S1, CsrA, ProQ and PNPase. Our findings suggest that IsrA might be directly involved in transcription or can participate in regulation of gene expression by delivering proteins associated with it to target mRNAs through its interactions with transcribing RNAP and through regions of sequence-complementarity with the target. In this eukaryotic-like model only in the context of a complex with its target, IsrA and its associated proteins become active. In this manner, in the form of sRNPs, bacterial sRNAs could regulate a number of targets with various outcomes, depending on the set of associated proteins. PMID:26609136

  2. Control design and analysis for underactuated robotic systems

    Xin, Xin

    2014-01-01

    The last two decades have witnessed considerable progress in the study of underactuated robotic systems (URSs). Control Design and Analysis for Underactuated Robotic Systems presents a unified treatment of control design and analysis for a class of URSs, which include systems with multiple-degree-of-freedom and/or with underactuation degree two. It presents novel notions, features, design techniques, and strictly global motion analysis results for these systems. These new materials are shown to be vital in studying the control design and stability analysis of URSs. Control Design and Analysis for Underactuated Robotic Systems includes the modelling, control design, and analysis presented in a systematic way particularly for the following examples: l  directly and remotely driven  Acrobots l  Pendubot l  rotational pendulum l  counter-weighted Acrobot 2-link underactuated robot with flexible elbow joint l  variable-length pendulum l  3-link gymnastic robot with passive first joint l  n-link planar robo...

  3. Analysis and experimental study of MIMO control in refrigeration system

    For various operating conditions and loads of refrigeration systems, converters are used to change the compressor's speed, and electronic expansion valves are adopted to regulate refrigerant flow rates. The refrigeration system, as a process under control, is a multi-input multi-output (MIMO) and nonlinear complex system. Based on the analysis of fuzzy and neural networks control, a self organized fuzzy neural network controller with the capacity of construction and parameter learning is proposed according to the simplified fuzzy control algorithm and the similarity between structure and function of a counter propagation network (CPN). This controller is easily structured with the feature of fuzzy control, and it also possesses the learning ability of neutral networks. The air cooled refrigeration experimental results show that the present controller can modulate the evaporation pressure and the superheating

  4. MULTI-CRITERIA ANALYSIS AS A TOOL FOR MUNICIPAL PROPERTY MANAGEMENT

    2011-01-01

    In most decision making situations more than one criterion is involved and, as a consequence, confusion can arise if there is no logical and well structured decision-making process in place. The multi-criteria analysis (MCA) constitutes a tool that can help evaluate the relative importance of all criteria involved and reflect on their importance during project management and decision making. MCA is a management tool aiming at supporting decision makers faced with making numerous and conflicti...

  5. Coarse-grained Dynamic Taint Analysis for Defeating Control and Non-control Data Attacks

    Kohli, Pankaj

    2009-01-01

    Memory corruption attacks remain the primary threat for computer security. Information flow tracking or taint analysis has been proven to be effective against most memory corruption attacks. However, there are two shortcomings with current taint analysis based techniques. First, these techniques cause application slowdown by about 76% thereby limiting their practicality. Second, these techniques cannot handle non-control data attacks i.e., attacks that do not overwrite control data such as re...

  6. Analysis and Comparison of Access Control Policies Validation Mechanisms

    Muhammad Aqib

    2014-12-01

    Full Text Available Validation and verification of security policies is a critical and important task to ensure that access control policies are error free. The two most common problems present in access control policies are: inconsistencies and incompleteness. In order to detect such problems, various access control policy validation mechanisms are proposed by the researchers. However, comprehensive analysis and evaluation of the existing access control policy validation techniques is missing in the literature. In this paper, we have provided a first detailed survey of this domain and presented the taxonomy of the access control policy validation mechanisms. Furthermore, we have provided a qualitative comparison and trend analysis of the existing schemes. From this survey, we found that only few validation mechanisms exist that can handle both inconsistency and incompleteness problem. Also, most of the policy validation techniques are inefficient in handling continuous values and Boolean expressions.

  7. Hybrid Formulations of Liposomes and Bioadhesive Polymers Improve the Hypotensive Effect of the Melatonin Analogue 5-MCA-NAT in Rabbit Eyes

    Palma, Santiago; Allemandi, Daniel; Herrero-Vanrell, Rocío; Molina-Martínez, Irene T.

    2014-01-01

    For the treatment of chronic ocular diseases such as glaucoma, continuous instillations of eye drops are needed. However, frequent administrations of hypotensive topical formulations can produce adverse ocular surface effects due to the active substance or other components of the formulation, such as preservatives or other excipients. Thus the development of unpreserved formulations that are well tolerated after frequent instillations is an important challenge to improve ophthalmic chronic topical therapies. Furthermore, several components can improve the properties of the formulation in terms of efficacy. In order to achieve the mentioned objectives, we have developed formulations of liposomes (150–200 nm) containing components similar to those in the tear film and loaded with the hypotensive melatonin analog 5-methoxycarbonylamino-N-acetyltryptamine (5-MCA-NAT, 100 µM). These formulations were combined with mucoadhesive (sodium hyaluronate or carboxymethylcellulose) or amphiphilic block thermosensitive (poloxamer) polymers to prolong the hypotensive efficacy of the drug. In rabbit eyes, the decrease of intraocular pressure with 5-MCA-NAT-loaded liposomes that were dispersed with 0.2% sodium hyaluronate, 39.1±2.2%, was remarkably higher compared to other liposomes formulated without or with other bioadhesive polymers, and the effect lasted more than 8 hours. According to the results obtained in the present work, these technological strategies could provide an improved modality for delivering therapeutic agents in patients with glaucoma. PMID:25329636

  8. T Cell Intrinsic USP15 Deficiency Promotes Excessive IFN-γ Production and an Immunosuppressive Tumor Microenvironment in MCA-Induced Fibrosarcoma

    Qiang Zou

    2015-12-01

    Full Text Available USP15 is a deubiquitinase that negatively regulates activation of naive CD4+ T cells and generation of IFN-γ-producing T helper 1 (Th1 cells. USP15 deficiency in mice promotes antitumor T cell responses in a transplantable cancer model; however, it has remained unclear how deregulated T cell activation impacts primary tumor development during the prolonged interplay between tumors and the immune system. Here, we find that the USP15-deficient mice are hypersensitive to methylcholantrene (MCA-induced fibrosarcomas. Excessive IFN-γ production in USP15-deficient mice promotes expression of the immunosuppressive molecule PD-L1 and the chemokine CXCL12, causing accumulation of T-bet+ regulatory T cells and CD11b+Gr-1+ myeloid-derived suppressor cells at tumor site. Mixed bone marrow adoptive transfer studies further reveals a T cell-intrinsic role for USP15 in regulating IFN-γ production and tumor development. These findings suggest that T cell intrinsic USP15 deficiency causes excessive production of IFN-γ, which promotes an immunosuppressive tumor microenvironment during MCA-induced primary tumorigenesis.

  9. Analysis and design of robust decentralized controllers for nonlinear systems

    Schoenwald, D.A.

    1993-07-01

    Decentralized control strategies for nonlinear systems are achieved via feedback linearization techniques. New results on optimization and parameter robustness of non-linear systems are also developed. In addition, parametric uncertainty in large-scale systems is handled by sensitivity analysis and optimal control methods in a completely decentralized framework. This idea is applied to alleviate uncertainty in friction parameters for the gimbal joints on Space Station Freedom. As an example of decentralized nonlinear control, singular perturbation methods and distributed vibration damping are merged into a control strategy for a two-link flexible manipulator.

  10. Using bioluminescent biosensors for hazard analysis and critical control point (HACCP) in wastewater control.

    Valat, C; Champiat, D; Degorce-Dumas, J R; Thomas, O

    2004-01-01

    Starting from a new approach for water pollution control and wastewater treatment plant management, the hazard analysis and critical control point (HACCP) quality concept, the interest for the development of new rapid and sensitive methods such as bioluminescence-based methods is evident. After an introduction of the HACCP procedure, a bibliographic study of the bioluminescence potentiality is presented and discussed. PMID:14979548

  11. Task analysis methods applicable to control room design review (CDR)

    This report presents the results of a research study conducted in support of the human factors engineering program of the Atomic Energy Control Board in Canada. It contains five products which may be used by the Atomic Enegy Control Board in relation to Task Analysis of jobs in CANDU nuclear power plants: 1. a detailed method for preparing for a task analysis; 2. a Task Data Form for recording task analysis data; 3. a detailed method for carrying out task analyses; 4. a guide to assessing alternative methods for performing task analyses, if such are proposed by utilities or consultants; and 5. an annotated bibliography on task analysis. In addition, a short explanation of the origins, nature and uses of task analysis is provided, with some examples of its cost effectiveness. 35 refs

  12. REVIEW OF NRC APPROVED DIGITAL CONTROL SYSTEMS ANALYSIS

    Preliminary design concepts for the proposed Subsurface Repository at Yucca Mountain indicate extensive reliance on modern, computer-based, digital control technologies. The purpose of this analysis is to investigate the degree to which the U. S. Nuclear Regulatory Commission (NRC) has accepted and approved the use of digital control technology for safety-related applications within the nuclear power industry. This analysis reviews cases of existing digitally-based control systems that have been approved by the NRC. These cases can serve as precedence for using similar types of digitally-based control technologies within the Subsurface Repository. While it is anticipated that the Yucca Mountain Project (YMP) will not contain control systems as complex as those required for a nuclear power plant, the review of these existing NRC approved applications will provide the YMP with valuable insight into the NRCs review process and design expectations for safety-related digital control systems. According to the YMP Compliance Program Guidance, portions of various NUREGS, Regulatory Guidelines, and nuclear IEEE standards the nuclear power plant safety related concept would be applied to some of the designs on a case-by-case basis. This analysis will consider key design methods, capabilities, successes, and important limitations or problems of selected control systems that have been approved for use in the Nuclear Power industry. An additional purpose of this analysis is to provide background information in support of further development of design criteria for the YMP. The scope and primary objectives of this analysis are to: (1) Identify and research the extent and precedence of digital control and remotely operated systems approved by the NRC for the nuclear power industry. Help provide a basis for using and relying on digital technologies for nuclear related safety critical applications. (2) Identify the basic control architecture and methods of key digital control

  13. REVIEW OF NRC APPROVED DIGITAL CONTROL SYSTEMS ANALYSIS

    D.W. Markman

    1999-09-17

    Preliminary design concepts for the proposed Subsurface Repository at Yucca Mountain indicate extensive reliance on modern, computer-based, digital control technologies. The purpose of this analysis is to investigate the degree to which the U. S. Nuclear Regulatory Commission (NRC) has accepted and approved the use of digital control technology for safety-related applications within the nuclear power industry. This analysis reviews cases of existing digitally-based control systems that have been approved by the NRC. These cases can serve as precedence for using similar types of digitally-based control technologies within the Subsurface Repository. While it is anticipated that the Yucca Mountain Project (YMP) will not contain control systems as complex as those required for a nuclear power plant, the review of these existing NRC approved applications will provide the YMP with valuable insight into the NRCs review process and design expectations for safety-related digital control systems. According to the YMP Compliance Program Guidance, portions of various NUREGS, Regulatory Guidelines, and nuclear IEEE standards the nuclear power plant safety related concept would be applied to some of the designs on a case-by-case basis. This analysis will consider key design methods, capabilities, successes, and important limitations or problems of selected control systems that have been approved for use in the Nuclear Power industry. An additional purpose of this analysis is to provide background information in support of further development of design criteria for the YMP. The scope and primary objectives of this analysis are to: (1) Identify and research the extent and precedence of digital control and remotely operated systems approved by the NRC for the nuclear power industry. Help provide a basis for using and relying on digital technologies for nuclear related safety critical applications. (2) Identify the basic control architecture and methods of key digital control

  14. Control Flow Analysis for the Pi-calculus

    Bodei, C.; Degano, P.; Nielson, Flemming; Nielson, Hanne Riis

    Control Flow Analysis is a static technique for predicting safe and computable approximations to the set of values that the objects of a program may assume during its execution. We present an analysis for the pi-calculus that shows how names will be bound to actual channels at run time. The...... formulation of the analysis requires no extensions to the pi-calculus, except for assigning ``channels'' to the occurrences of names within restrictions, and assigning ``binders'' to the occurrences of names within input prefixes. The result of our analysis establishes a super-set of the set of names to which...

  15. Control Flow Analysis for the Pi-calculus

    Bodei, C.; Degano, P.; Nielson, Flemming;

    1998-01-01

    Control Flow Analysis is a static technique for predicting safe and computable approximations to the set of values that the objects of a program may assume during its execution. We present an analysis for the pi-calculus that shows how names will be bound to actual channels at run time. The...... formulation of the analysis requires no extensions to the pi-calculus, except for assigning ``channels'' to the occurrences of names within restrictions, and assigning ``binders'' to the occurrences of names within input prefixes. The result of our analysis establishes a super-set of the set of names to which...

  16. Stability and Sensitivity Analysis of Fuzzy Control Systems. Mechatronics Applications

    Radu-Emil Precup

    2006-01-01

    Full Text Available The development of fuzzy control systems is usually performed by heuristicmeans, incorporating human skills, the drawback being in the lack of general-purposedevelopment methods. A major problem, which follows from this development, is theanalysis of the structural properties of the control system, such as stability, controllabilityand robustness. Here comes the first goal of the paper, to present a stability analysismethod dedicated to fuzzy control systems with mechatronics applications based on the useof Popov’s hyperstability theory. The second goal of this paper is to perform the sensitivityanalysis of fuzzy control systems with respect to the parametric variations of the controlledplant for a class of servo-systems used in mechatronics applications based on theconstruction of sensitivity models. The stability and sensitivity analysis methods provideuseful information to the development of fuzzy control systems. The case studies concerningfuzzy controlled servo-systems, accompanied by digital simulation results and real-timeexperimental results, validate the presented methods.

  17. Pressure Control in Distillation Columns: A Model-Based Analysis

    Mauricio Iglesias, Miguel; Bisgaard, Thomas; Kristensen, Henrik;

    2014-01-01

    A comprehensive assessment of pressure control in distillation columns is presented, including the consequences for composition control and energy consumption. Two types of representative control structures are modeled, analyzed, and benchmarked. A detailed simulation test, based on a real...... industrial distillation column, is used to assess the differences between the two control structures and to demonstrate the benefits of pressure control in the operation. In the second part of the article, a thermodynamic analysis is carried out to establish the influence of pressure on relative volatility...... differences. Depending on the sensitivity of relative volatility to pressure, it is shown that controlling the bottom-tray pressure instead of the top-tray pressure leads to operation at the minimum possible average column pressure, so that significant energy savings can be achieved....

  18. REACTOR ANALYSIS AND VIRTUAL CONTROL ENVIRONMENT (RAVEN) FY12 REPORT

    Cristian Rabiti; Andrea Alfonsi; Joshua Cogliati; Diego Mandelli; Robert Kinoshita

    2012-09-01

    RAVEN is a complex software tool that will have tasks spanning from being the RELAP-7 user interface, to using RELAP-7 to perform Risk Informed Safety Characterization (RISMC), and to controlling RELAP-7 calculation execution. The goal of this document is to: 1. Highlight the functional requirements of the different tasks of RAVEN 2. Identify shared functions that could be aggregate in modules so to obtain a minimal software redundancy and maximize software utilization. RAVEN is in fact a software framework that will allow exploiting the following functionalities: • Derive and actuate the control logic required to: o Simulate the plant control system o Simulate the operator (procedure guided) actions o Perform Monte Carlo sampling of random distributed events o Perform event three based analysis • Provide a GUI to: o Input a plant description to RELAP-7 (component, control variable, control parameters) o Concurrent monitoring of Control Parameters o Concurrent alteration of control parameters • Provide Post Processing data mining capability based on o Dimensionality reduction o Cardinality reduction In this document it will be shown how an appropriate mathematical formulation of the control logic and probabilistic analysis leads to have most of the software infrastructure leveraged between the two main tasks. Further, this document will go through the development accomplished this year, including simulation results, and priorities for the next years development

  19. Sensitivity Analysis and Optimal Control of Anthroponotic Cutaneous Leishmania

    Zamir, Muhammad; Zaman, Gul; Alshomrani, Ali Saleh

    2016-01-01

    This paper is focused on the transmission dynamics and optimal control of Anthroponotic Cutaneous Leishmania. The threshold condition R0 for initial transmission of infection is obtained by next generation method. Biological sense of the threshold condition is investigated and discussed in detail. The sensitivity analysis of the reproduction number is presented and the most sensitive parameters are high lighted. On the basis of sensitivity analysis, some control strategies are introduced in the model. These strategies positively reduce the effect of the parameters with high sensitivity indices, on the initial transmission. Finally, an optimal control strategy is presented by taking into account the cost associated with control strategies. It is also shown that an optimal control exists for the proposed control problem. The goal of optimal control problem is to minimize, the cost associated with control strategies and the chances of infectious humans, exposed humans and vector population to become infected. Numerical simulations are carried out with the help of Runge-Kutta fourth order procedure. PMID:27505634

  20. Facilitator control as automatic behavior: A verbal behavior analysis

    Hall, Genae A.

    1993-01-01

    Several studies of facilitated communication have demonstrated that the facilitators were controlling and directing the typing, although they appeared to be unaware of doing so. Such results shift the focus of analysis to the facilitator's behavior and raise questions regarding the controlling variables for that behavior. This paper analyzes facilitator behavior as an instance of automatic verbal behavior, from the perspective of Skinner's (1957) book Verbal Behavior. Verbal behavior is autom...

  1. Tobacco control in the Russian Federation- a policy analysis

    Lunze, Karsten; Migliorini, Luigi

    2013-01-01

    Background The Russian Federation (Russia) has one of the highest smoking rates in the world. The purpose of this study is to analyze past and current trends of the tobacco epidemic in the Russian Federation, review current tobacco control policy responses, and identify areas of opportunity for policy priorities. Methods We used a policy triangle as analytical framework to examine content, context, and processes of Russian tobacco control policy. The analysis was based on secondary data on su...

  2. Analysis of Dynamic Road Traffic Congestion Control (DRTCC) Techniques

    Pardeep Mittal; Yashpal Singh,; Yogesh Sharma

    2015-01-01

    : Dynamic traffic light control at intersection has become one of the most active research areas to develop the Dynamic transportation systems (ITS). Due to the consistent growth in urbanization and traffic congestion, such a system was required which can control the timings of traffic lights dynamically with accurate measurement of traffic on the road. In this paper, analysis of all the techniques that has been developed to automate the traffic lights has been done.. The efficacy...

  3. catmap: Case-control And TDT Meta-Analysis Package

    Nicodemus, Kristin K.

    2008-01-01

    Background Risk for complex disease is thought to be controlled by multiple genetic risk factors, each with small individual effects. Meta-analyses of several independent studies may be helpful to increase the ability to detect association when effect sizes are modest. Although many software options are available for meta-analysis of genetic case-control data, no currently available software implements the method described by Kazeem and Farrall (2005), which combines data from independent fam...

  4. Dynamics and control: energy conversion, delivery, and demand analysis

    Hoffman, K.C.

    1979-04-01

    Techniques of mathematical modeling and modern control theory, using microprocessors and advanced measurement and control devices, are extensively applied to components and systems for the conversion and delivery of energy. The projection of energy demands, as a function of economic growth and energy price, is also the subject of active research and analysis. This position paper reviews the current state-of-the-art of analysis in these areas dealing with the planning and operation of energy systems that deliver fuels and electric power. Future research directions are also discussed. 25 references.

  5. Analysis and control of an anaerobic upflow Fixed bed bioreactor

    This paper presents the bifurcation analysis in an anaerobic upflow fixed bed bioreactor, which is an anaerobic digestion system useful for wastewater treatment. In the dynamic analysis part, the equilibrium points, linear stability and bifurcation curves are studied, focusing in the washout condition. For the self tuning regulator the parameter estimation and control law are designed, and an integral action is introduced in order to address the disturbances. The simulation studies show the improvement of the performance when a disturbance appears.

  6. STANDARDIZATION FOR SUBGROUP ANALYSIS IN RANDOMIZED CONTROLLED TRIALS

    Varadhan, Ravi; Wang, Sue-Jane

    2014-01-01

    Randomized controlled trials (RCTs) emphasize the average or overall effect of a treatment (ATE) on the primary endpoint. Even though the ATE provides the best summary of treatment efficacy, it is of critical importance to know whether the treatment is similarly efficacious in important, predefined subgroups. This is why the RCTs, in addition to the ATE, also present the results of subgroup analysis for preestablished subgroups. Typically, these are marginal subgroup analysis in the sense tha...

  7. Motion analysis and remote control system using pyroelectric infrared sensors

    Fuksis, R.; Greitans, M.; Hermanis, E.

    2008-01-01

    The paper discusses the possibilities of exploiting infrared radiation for motion analysis and remote control. The human body is considered as the information source and dual-element pyroelectric infrared (PIR) detectors as the sensor system. A dual-element sensor allows the analysis of the motion of objects in one-dimension, therefore it is proposed to place two sensors perpendicularly. Such a method provides the capability of distinguishing eight different commands. An experimental set-up h...

  8. Control capability analysis for complex spacecraft thruster configurations

    2010-01-01

    The set of forces and moments that can be generated by thrusters of a spacecraft is called the"control capability"with respect to the thruster configuration.If the control capability of a thruster configuration is adequate to fulfill a given space mission,we say this configuration is a feasible one with respect to the task.This study proposed a new way to analyze the control capability of the complex thruster configuration.Precise mathematical definitions of feasibility were proposed,based on which a criterion to judge the feasibility of the thruster configuration was presented through calculating the shortest distance to the boundary of the controllable region as a function of the thruster configuration.Finally,control capability analysis for the complex thruster configuration based on its feasibility with respect to the space mission was given followed by a 2-D thruster configuration example to demonstrate its validity.

  9. Stability Analysis on Speed Control System of Autonomous Underwater Vehicle

    LI Ye; PANG Yong-jie; WAN Lei; WANG Fang; LIAO Yu-lei

    2009-01-01

    The stability of the motion control system is one of the decisive factors of the control quality for Autonomous Underwater Vehicle (AUV).The divergence of control,which the unstable system may be brought about,is fatal to the operation of AUV.The stability analysis of the PD and S-surface speed controllers based on the Lyapunov' s direct method is proposed in this paper.After decoupling the six degree-of-freedom (DOF) motions of the AUV,the axial dynamic behavior is discussed and the condition is deduced,in which the parameters selection within stability domain can guarantee the system asymptotically stable.The experimental results in a tank and on the sea have successfully verified the algorithm reliability,which can be served as a good reference for analyzing other AUV nonlinear control systems.

  10. Quantitative cerebral perfusion assessment using microscope-integrated analysis of intraoperative indocyanine green fluorescence angiography versus positron emission tomography in superficial temporal artery to middle cerebral artery anastomosis

    Shinya Kobayashi

    2014-01-01

    Full Text Available Background: Intraoperative qualitative indocyanine green (ICG angiography has been used in cerebrovascular surgery. Hyperperfusion may lead to neurological complications after superficial temporal artery to middle cerebral artery (STA-MCA anastomosis. The purpose of this study is to quantitatively evaluate intraoperative cerebral perfusion using microscope-integrated dynamic ICG fluorescence analysis, and to assess whether this value predicts hyperperfusion syndrome (HPS after STA-MCA anastomosis. Methods: Ten patients undergoing STA-MCA anastomosis due to unilateral major cerebral artery occlusive disease were included. Ten patients with normal cerebral perfusion served as controls. The ICG transit curve from six regions of interest (ROIs on the cortex, corresponding to ROIs on positron emission tomography (PET study, was recorded. Maximum intensity (I MAX , cerebral blood flow index (CBFi, rise time (RT, and time to peak (TTP were evaluated. Results: RT/TTP, but not I MAX or CBFi, could differentiate between control and study subjects. RT/TTP correlated (|r| = 0.534-0.807; P < 0.01 with mean transit time (MTT/MTT ratio in the ipsilateral to contralateral hemisphere by PET study. Bland-Altman analysis showed a wide limit of agreement between RT and MTT and between TTP and MTT. The ratio of RT before and after bypass procedures was significantly lower in patients with postoperative HPS than in patients without postoperative HPS (0.60 ± 0.032 and 0.80 ± 0.056, respectively; P = 0.017. The ratio of TTP was also significantly lower in patients with postoperative HPS than in patients without postoperative HPS (0.64 ± 0.081 and 0.85 ± 0.095, respectively; P = 0.017. Conclusions: Time-dependent intraoperative parameters from the ICG transit curve provide quantitative information regarding cerebral circulation time with quality and utility comparable to information obtained by PET. These parameters may help predict the occurrence of postoperative

  11. A new TXRF vacuum chamber with sample changer for chemical analysis using silicon drift chamber detector

    Full text: Several TXRF spectrometers for chemical analysis as well as for wafer surface analysis are commercially available. But there is no one available for chemical analysis offering the possibility to measure the samples in vacuum conditions. Vacuum of 10-2 mbar in the sample environment helps to reduce the background due to scattering from air, thus to improve the detection limits as well as to reduce the absorption of low energy fluorescence radiation from low Z elements and extend the elemental range to be measured and removes the Ar lines from the spectrum. The x-ray group of the Atominstitut designed and fabricated a new vacuum chamber for TXRF equipped with a 12 position sample changer from Italstructures, Riva, Italy. The detector used was a 10 mm2 silicon drift detector (KETEK, Munich, Germany), offering the advantage of electrically cooling, so no LN2 is required. The chamber was designed to be attached to a diffraction tube housing, e.g. with a fine focus Mo-x-ray tube and uses a multilayer monochromator. Spectra are stored by a small AMTEK MCA and control between sample changer and MCA communication is done by a modified AMPTEK software. The performance is expressed in detection limits of 1 pg Rb for Mo Ka excitation with 50 kV, 40 mA excitation conditions, 1000 s lifetime, obtained from a sample containing 600 pg Rb as single element standard. Details on performance, reproducibility and light element excitation and detection are presented. (author)

  12. Analysis of junction-barrier-controlled Schottky (JBS) rectifier characteristics

    Baliga, B. Jayant

    1985-11-01

    This paper provides analytical solutions for the forward conduction and reverse leakage characteristics of junction-barrier-controlled Schottky (JBS) rectifiers. Good agreement between the calculated output characteristics using these solutions and experimental measurements on devices fabricated with different junction depths and Schottky barrier heights is observed. These equations are valuable for the analysis and design of JBS power rectifiers.

  13. Integration of Design and Control Through Model Analysis

    Russel, Boris Mariboe; Henriksen, Jens Peter; Jørgensen, Sten Bay;

    2000-01-01

    phenomena models representing the process model identify the relationships between the important process and design variables, which help to understand, define and address some of the issues related to integration of design and control issues. The model analysis is highlighted through examples involving...... processes with mass and/or energy recycle. (C) 2000 Elsevier Science Ltd. All rights reserved....

  14. Harmoniousness analysis of total amount control of water use

    Qian-qi YIN; Guo-hua FANG

    2014-01-01

    Based on the fundamental principles of total amount control of water use, the harmony theory was used in this study to develop a concept of the degree of harmony of total amount control of water use. Based on this concept, the harmoniousness of total amount control of water use was analyzed in terms of the supply and demand of water resources, water resources management, water use benefits, and water-saving level. An evaluation index system of the degree of harmony of total amount control of water use was established, and a method for calculation of the degree of harmony of total amount control of water use was developed based on the analytic hierarchy process (AHP) and fuzzy comprehensive analysis (FCA) methods. The new evaluation index system was applied to a certain area in Jiangsu Province, China. The degree of harmony of total amount control of water use over this area was calculated for different years. Results indicate that the evaluation index system and calculation method proposed in this study are feasible, and such a harmoniousness analysis can provide scientific references for the strict water resources management system that will be implemented in China in the near future.

  15. Harmoniousness analysis of total amount control of water use

    Qian-qi YIN

    2014-01-01

    Full Text Available Based on the fundamental principles of total amount control of water use, the harmony theory was used in this study to develop a concept of the degree of harmony of total amount control of water use. Based on this concept, the harmoniousness of total amount control of water use was analyzed in terms of the supply and demand of water resources, water resources management, water use benefits, and water-saving level. An evaluation index system of the degree of harmony of total amount control of water use was established, and a method for calculation of the degree of harmony of total amount control of water use was developed based on the analytic hierarchy process (AHP and fuzzy comprehensive analysis (FCA methods. The new evaluation index system was applied to a certain area in Jiangsu Province, China. The degree of harmony of total amount control of water use over this area was calculated for different years. Results indicate that the evaluation index system and calculation method proposed in this study are feasible, and such a harmoniousness analysis can provide scientific references for the strict water resources management system that will be implemented in China in the near future.

  16. Cost/benefit analysis of eliminating poison control in LWRs

    Since the economics of power generation determines, to a large extent,a utility's choice of reactor systems, the cost of electricity from a spectral shift control (SSC) reactor is a crucial measure of the SSC reactor's competitiveness. Thus, a preliminary cost analysis is an important part of our overall assessment. The economic comparisons in this work focus on the cost differences between a standard pressurized water reactor (PWR) and the breeder/moderator controlled/burner light water reactor (BMB-LWR) design concept. The BMB-LWR is a typical large current design PWR with a minimum of changes. The BMB-LWR does not use any poison for reactivity control in the cycle length range of interest (1 to 2 yr) and uses soluble poison only for refueling purposes, to provide a sufficient additional negative reactivity margin to supplement the water displacement system. However, the water displacement system is very similar to the control rod system from a mechanical design point of view, differing mainly in the characteristics of the in-core control pins. Mixing both poison and displacer pins in the same core introduces added complexity, but not necessarily at a large cost impact; e.g., the advanced PWR has substantial water displacement control components, whereas the BMB-LWR primarily increases the displacer-to-poison ratio. The annual credits and penalties of replacing the standard PWR with the BMB-LWR concept are covered in the analysis

  17. Chaos in electric drive systems analysis control and application

    Chau, K T

    2011-01-01

    In Chaos in Electric Drive Systems: Analysis, Control and Application authors Chau and Wang systematically introduce an emerging technology of electrical engineering that bridges abstract chaos theory and practical electric drives. The authors consolidate all important information in this interdisciplinary technology, including the fundamental concepts, mathematical modeling, theoretical analysis, computer simulation, and hardware implementation. The book provides comprehensive coverage of chaos in electric drive systems with three main parts: analysis, control and application. Corresponding drive systems range from the simplest to the latest types: DC, induction, synchronous reluctance, switched reluctance, and permanent magnet brushless drives.The first book to comprehensively treat chaos in electric drive systemsReviews chaos in various electrical engineering technologies and drive systemsPresents innovative approaches to stabilize and stimulate chaos in typical drivesDiscusses practical application of cha...

  18. A Calculus for Control Flow Analysis of Security Protocols

    Buchholtz, Mikael; Nielson, Hanne Riis; Nielson, Flemming

    2004-01-01

    The design of a process calculus for anaysing security protocols is governed by three factors: how to express the security protocol in a precise and faithful manner, how to accommodate the variety of attack scenarios, and how to utilise the strengths (and limit the weaknesses) of the underlying...... analysis methodology. We pursue an analysis methodology based on control flow analysis in flow logic style and we have previously shown its ability to analyse a variety of security protocols. This paper develops a calculus, LysaNS that allows for much greater control and clarity in the description of...... attack scenarios, that gives a more flexible format for expressing protocols, and that at the same time allows to circumvent some of the ``false positives'' arising in previous work....

  19. Page: a program for gamma spectra analysis in PC microcomputers

    PAGE is a software package, written in BASIC language, to perform gamma spectra analysis. It was developed to be used in a high-purity intrinsic germanium detector-multichannel analyser-PC microcomputer system. The analysis program of PAGE package accomplishes functions as follows: peak location; gamma nuclides identification; activity determination. Standard nuclides sources were used to calibrate the system. To perform the efficiency x energy calibration a logarithmic fit was applied. Analysis of nuclides with overlapping peaks is allowed by PAGE program. PAGE has additional auxiliary programs for: building and list of isotopic nuclear data libraries; data acquisition from multichannel analyser; spectrum display with automatic area and FWHM determinations. This software is to be applied in analytical process control where time response is a very important parameter. PAGE takes ca. 1.5 minutes to analyse a complex spectrum from a 4096 channels MCA. (author)

  20. Multi Criteria Analysis for bioenergy systems assessments

    Sustainable bioenergy systems are, by definition, embedded in social, economic, and environmental contexts and depend on support of many stakeholders with different perspectives. The resulting complexity constitutes a major barrier to the implementation of bioenergy projects. The goal of this paper is to evaluate the potential of Multi Criteria Analysis (MCA) to facilitate the design and implementation of sustainable bioenergy projects. Four MCA tools (Super Decisions, DecideIT, Decision Lab, NAIADE) are reviewed for their suitability to assess sustainability of bioenergy systems with a special focus on multi-stakeholder inclusion. The MCA tools are applied using data from a multi-stakeholder bioenergy case study in Uganda. Although contributing to only a part of a comprehensive decision process, MCA can assist in overcoming implementation barriers by (i) structuring the problem, (ii) assisting in the identification of the least robust and/or most uncertain components in bioenergy systems and (iii) integrating stakeholders into the decision process. Applying the four MCA tools to a Ugandan case study resulted in a large variability in outcomes. However, social criteria were consistently identified by all tools as being decisive in making a bioelectricity project viable

  1. Preliminary control system design and analysis for the Space Station Furnace Facility thermal control system

    Jackson, M. E.

    1995-01-01

    This report presents the Space Station Furnace Facility (SSFF) thermal control system (TCS) preliminary control system design and analysis. The SSFF provides the necessary core systems to operate various materials processing furnaces. The TCS is defined as one of the core systems, and its function is to collect excess heat from furnaces and to provide precise cold temperature control of components and of certain furnace zones. Physical interconnection of parallel thermal control subsystems through a common pump implies the description of the TCS by coupled nonlinear differential equations in pressure and flow. This report formulates the system equations and develops the controllers that cause the interconnected subsystems to satisfy flow rate tracking requirements. Extensive digital simulation results are presented to show the flow rate tracking performance.

  2. Stability Analysis and Design of Impulsive Control Lorenz Systems Family

    YU Yong-Bin; ZHANG Hong-Bin; ZHANG Feng-Li; YU Jue-Bang; LIAO Xiao-Feng

    2009-01-01

    Lorenz systems family unifying Lorenz system, Chen system and Lu system is a typical chaotic family.In this paper, we consider impulsive control Lorenz chaotic systems family with time-varying impulse intervals. By establishing an effective tool of a set of inequalities, we analyze the asymptotic stability of impulsive control Lorenz systems family and obtain some new less conservative conditions. Based on the stability analysis, we design a novel impulsive controller with time-varying impulse intervals. Illustrative examples are provided to show the feasibility and effectiveness of our method. The obtained results not only can be used to design impulsive control for Lorenz systems family, but also can be extended to other chaotic systems.

  3. Stability Analysis and Design of Impulsive Control Lorenz Systems Family

    Lorenz systems family unifying Lorenz system, Chen system and Lue system is a typical chaotic family. In this paper, we consider impulsive control Lorenz chaotic systems family with time-varying impulse intervals. By establishing an effective tool of a set of inequalities, we analyze the asymptotic stability of impulsive control Lorenz systems family and obtain some new less conservative conditions. Based on the stability analysis, we design a novel impulsive controller with time-varying impulse intervals. Illustrative examples are provided to show the feasibility and effectiveness of our method. The obtained results not only can be used to design impulsive control for Lorenz systems family, but also can be extended to other chaotic systems. (general)

  4. Analysis of Dynamic Road Traffic Congestion Control (DRTCC Techniques

    Pardeep Mittal

    2015-10-01

    Full Text Available : Dynamic traffic light control at intersection has become one of the most active research areas to develop the Dynamic transportation systems (ITS. Due to the consistent growth in urbanization and traffic congestion, such a system was required which can control the timings of traffic lights dynamically with accurate measurement of traffic on the road. In this paper, analysis of all the techniques that has been developed to automate the traffic lights has been done.. The efficacy of all the techniques has been evaluated, using MATLAB software. After comparison of artificial intelligent techniques , it is found that image mosaicking technique is quite effective (in terms of improving moving time and reducing waiting time for the control of the traffic signals to control congestion on the road.

  5. Rotor-Flying Manipulator: Modeling, Analysis, and Control

    Bin Yang

    2014-01-01

    Full Text Available Equipping multijoint manipulators on a mobile robot is a typical redesign scheme to make the latter be able to actively influence the surroundings and has been extensively used for many ground robots, underwater robots, and space robotic systems. However, the rotor-flying robot (RFR is difficult to be made such redesign. This is mainly because the motion of the manipulator will bring heavy coupling between itself and the RFR system, which makes the system model highly complicated and the controller design difficult. Thus, in this paper, the modeling, analysis, and control of the combined system, called rotor-flying multijoint manipulator (RF-MJM, are conducted. Firstly, the detailed dynamics model is constructed and analyzed. Subsequently, a full-state feedback linear quadratic regulator (LQR controller is designed through obtaining linearized model near steady state. Finally, simulations are conducted and the results are analyzed to show the basic control performance.

  6. Application of maximin correlation analysis to classifying protein environments for function prediction.

    Lee, Taehoon; Min, Hyeyoung; Kim, Seung Jean; Yoon, Sungroh

    2010-09-17

    More and more protein structures are being discovered, but most of these still have little functional information. Based on the assumption that structural resemblance would lead to functional similarity, researchers computationally compare a new structure with functionally annotated structures, for high-throughput function prediction. The effectiveness of this approach depends critically upon the quality of comparison. In particular, robust classification often becomes difficult when a function class is an aggregate of multiple subclasses, as is the case with protein annotations. For such multiple-subclass classification problems, an optimal method termed the maximin correlation analysis (MCA) was proposed. However, MCA has never been applied to automated protein function prediction although MCA can minimize the misclassification risk in the correlation-based nearest neighbor classification, thus increasing classification accuracy. In this article, we apply MCA to classifying three-dimensional protein local environment data derived from a subset of the protein data bank (PDB). In our framework, the MCA-based classifier outperformed the compared alternatives by 7-19% and 6-27% in terms of average sensitivity and specificity, respectively. Given that correlation-based similarity measures have been widely used for mining protein data, we expect that MCA would be employed to enhance other types of automated function prediction methods. PMID:20719237

  7. Multihop Medium Access Control for WSNs: An Energy Analysis Model

    Haapola Jussi

    2005-01-01

    Full Text Available We present an energy analysis technique applicable to medium access control (MAC and multihop communications. Furthermore, the technique's application gives insight on using multihop forwarding instead of single-hop communications. Using the technique, we perform an energy analysis of carrier-sense-multiple-access (CSMA- based MAC protocols with sleeping schemes. Power constraints set by battery operation raise energy efficiency as the prime factor for wireless sensor networks. A detailed energy expenditure analysis of the physical, the link, and the network layers together can provide a basis for developing new energy-efficient wireless sensor networks. The presented technique provides a set of analytical tools for accomplishing this. With those tools, the energy impact of radio, MAC, and topology parameters on the network can be investigated. From the analysis, we extract key parameters of selected MAC protocols and show that some traditional mechanisms, such as binary exponential backoff, have inherent problems.

  8. Analysis of Droop Controlled Parallel Inverters in Islanded Microgrids

    Mariani, Valerio; Vasca, Francesco; Guerrero, Josep M.

    paper shows a systematic approach to derive a closed loop model of the microgrid and then to perform an eigenvalues analysis that highlights how the system’s parameters affect the stability of the network. It is also shown that by means of a singular perturbation approach the resulting reduced order......Three-phase droop controlled inverters are widely used in islanded microgrids to interface distributed energy resources and to provide for the loads active and reactive powers demand. The assessment of microgrids stability, affected by the control and line parameters, is a stringent issue. This...

  9. Applications of damping torque analysis to STATCOM control

    Wang, H.F. [University of Bath (United Kingdom). Dept. of Electronic and Electrical Engineering

    2000-03-01

    By applying the conventional technique of damping torque analysis, this paper investigates the effect of STATCOM AC and DC voltage regulator on power system oscillation damping and demonstrates the design of STATCOM damping controller by using the phase compensation method. The investigation reveals the negative influence of STATCOM AC and DC voltage regulator on power system oscillation damping which is confirmed by the results of eigenvalue computation and non-linear simulation of an example power system. The effectiveness of STATCOM damping controller designed by the phase compensation method to damp power system oscillations is also illustrated by the example power system. (author)

  10. Hydrothermal analysis in engineering using control volume finite element method

    Sheikholeslami, Mohsen

    2015-01-01

    Control volume finite element methods (CVFEM) bridge the gap between finite difference and finite element methods, using the advantages of both methods for simulation of multi-physics problems in complex geometries. In Hydrothermal Analysis in Engineering Using Control Volume Finite Element Method, CVFEM is covered in detail and applied to key areas of thermal engineering. Examples, exercises, and extensive references are used to show the use of the technique to model key engineering problems such as heat transfer in nanofluids (to enhance performance and compactness of energy systems),

  11. Analysis on Single Point Vulnerabilities of Plant Control System

    The Plant Control System (PCS) is a system that controls pumps, valves, dampers, etc. in nuclear power plants with an OPR-1000 design. When there is a failure or spurious actuation of the critical components in the PCS, it can result in unexpected plant trips or transients. From this viewpoint, single point vulnerabilities are evaluated in detail using failure mode effect analyses (FMEA) and fault tree analyses (FTA). This evaluation demonstrates that the PCS has many vulnerable components and the analysis results are provided for OPR-1000 plants for reliability improvements that can reduce their vulnerabilities

  12. A computer program for the algebraic determination of control coefficients in Metabolic Control Analysis.

    Thomas, S; Fell, D A

    1993-06-01

    A computer program (MetaCon) is described for the evaluation of flux control, concentration control and branch-point distribution control coefficients of a metabolic pathway. Requiring only the reaction scheme as input, the program produces algebraic expressions for the control coefficients in terms of elasticity coefficients, metabolite concentrations and pathway fluxes. Any of these variables can be substituted by numeric or simple algebraic expressions; the expressions will then be automatically rearranged in terms of the remaining unknown variables. When all variables have been substituted, numeric values will be obtained for the control coefficients. The program is a computerized implementation of the matrix method for the determination of control coefficients. The features of MetaCon are compared with those of other programs available to workers in Metabolic Control Analysis. Potential benefits of, and methods of using, MetaCon are discussed. The mathematical background and validity of the matrix method rules are discussed, and the algorithm used by MetaCon is described. The matrix method is shown to be a specific case of a previously described general formalism for calculating control coefficients. PMID:8503870

  13. Coarse-grained Dynamic Taint Analysis for Defeating Control and Non-control Data Attacks

    Kohli, Pankaj

    2009-01-01

    Memory corruption attacks remain the primary threat for computer security. Information flow tracking or taint analysis has been proven to be effective against most memory corruption attacks. However, there are two shortcomings with current taint analysis based techniques. First, these techniques cause application slowdown by about 76% thereby limiting their practicality. Second, these techniques cannot handle non-control data attacks i.e., attacks that do not overwrite control data such as return address, but instead overwrite critical application configuration data or user identity data. In this work, to address these problems, we describe a coarse-grained taint analysis technique that uses information flow tracking at the level of application data objects. We propagate a one-bit taint over each application object that is modified by untrusted data thereby reducing the taint management overhead considerably. We performed extensive experimental evaluation of our approach and show that it can detect all critic...

  14. Value-impact analysis for material control and accounting alternatives

    This paper describes the results of Value-Impact analysis for the proposed material control and accounting upgrade rule for Category I fuel facilities. The analysis uses the Aggregated Systems Model (ASM), one of several assessment methodologies developed at Lawrence Livermore National Laboratory (LLNL) under the auspices of the NRC's Office of Nuclear Regulatory Research, to evaluate safeguards decisions. The evaluations are based on data gathered from representative facilities processing special nuclear material (SNM). The paper focuses on an objective of the MCandA upgrade rule of having a 90 percent probability of detecting within 24 hours any large discrepancy of SNM. 3 refs

  15. Control of separation and quantitative analysis by GC-FTIR

    Semmoud, A.; Huvenne, Jean P.; Legrand, P.

    1992-03-01

    Software for 3-D representations of the 'Absorbance-Wavenumber-Retention time' is used to control the quality of the GC separation. Spectral information given by the FTIR detection allows the user to be sure that a chromatographic peak is 'pure.' The analysis of peppermint essential oil is presented as an example. This assurance is absolutely required for quantitative applications. In these conditions, we have worked out a quantitative analysis of caffeine. Correlation coefficients between integrated absorbance measurements and concentration of caffeine are discussed at two steps of the data treatment.

  16. Structural mode significance using INCA. [Interactive Controls Analysis computer program

    Bauer, Frank H.; Downing, John P.; Thorpe, Christopher J.

    1990-01-01

    Structural finite element models are often too large to be used in the design and analysis of control systems. Model reduction techniques must be applied to reduce the structural model to manageable size. In the past, engineers either performed the model order reduction by hand or used distinct computer programs to retrieve the data, to perform the significance analysis and to reduce the order of the model. To expedite this process, the latest version of INCA has been expanded to include an interactive graphical structural mode significance and model order reduction capability.

  17. Analysis of GPS Abnormal Conditions within Fault Tolerant Control Laws

    Al-Sinbol, Gahssan

    The Global Position System (GPS) is a critical element for the functionality of autonomous flying vehicles. The GPS operation at normal and abnormal conditions directly impacts the trajectory tracking performance of the autonomous Unmanned Aerial Vehicles (UAVs) controllers. The effects of GPS parameter variation must be well understood and user-friendly computational tools must be developed to facilitate the design and evaluation of fault tolerant control laws. This thesis presents the development of a simplified GPS error model in Matlab/Simulink and its use performing a sensitivity analysis of GPS parameters effect under system normal and abnormal operation on different UAV trajectory tracking controllers. The model statistically generates position and velocity errors, simulates the effect of GPS satellite configuration on the position and velocity measurement accuracy, and implements a set of failures to the GPS readings. The model and its graphical user interface was integrated within the WVU UAV simulation environment as a masked Simulink block. The effects on the controllers' trajectory tracking performance of the following GPS parameters were investigated within normal operation ranges and outside: time delay, update rate, error standard deviation, bias, and major position and velocity failures. Several sets of control laws with fixed and adaptive parameters and of different levels of complexity have been used in this investigation. A complex performance index formulated in terms of tracking errors and control activity was used for control laws performance evaluation. The composition of various metrics within the performance index was performed using fixed and variable weights depending on the local characteristics of the commanded trajectory. This study has revealed that GPS error parameters have a significant impact on control laws performance. The proposed GPS model has proved to be a valuable, flexible tool for testing and evaluation of the fault

  18. Statistical analysis of the blast furnace process output parameter using arima control chart with proposed methodology of control limits setting

    Noskievičová, Darja

    2009-01-01

    The paper deals with the statistical analysis of the selected parameter of the blast furnace process. It was proved that analyzed measurements have been autocorrelated. ARIMA control chart was selected for their analysis as a very useful statistical process control (SPC) method. At first the methodology for control limits setting in ARIMA control charts considering the time series outlier analysis as an integral part of the ARIMA model building was designed. Then this proposal was...

  19. Statistical analysis of the blast furnace process output parameter using arima control chart with proposed methodology of control limits setting

    D. Noskievičová

    2009-01-01

    The paper deals with the statistical analysis of the selected parameter of the blast furnace process. It was proved that analyzed measurements have been autocorrelated. ARIMA control chart was selected for their analysis as a very useful statistical process control (SPC) method. At first the methodology for control limits setting in ARIMA control charts considering the time series outlier analysis as an integral part of the ARIMA model building was designed. Then this proposal was applied to ...

  20. Control and analysis software for a laser scanning microdensitometer

    H R Bundel; C P Navathe; P A Naik; P D Gupta

    2006-02-01

    A PC-based control software and data acquisition system is developed for an existing commercial microdensitometer (Biomed make model No. SL-2D/1D UV/VIS) to facilitate scanning and analysis of X-ray films. The software is developed in Labview, which includes operation of the microdensitometer in 1D and 2D scans and analysis of spatial or spectral data on X-ray films, such as optical density, intensity and wavelength. It provides a user-friendly Graphical User Interface (GUI) to analyse the scanned data and also store the analysed data/image in popular formats like data in Excel and images in jpeg. It has also on-line calibration facility with standard optical density tablets. The control software and data acquisition system is simple, inexpensive and versatile.

  1. Analysis and test verification of control rod buffer in HTR

    The thin-walled shell buffer in high temperature gas-cooled reactor (HTR) was designed for absorbing the kinetic energy of the control rod drop in the drive line fracture accident. The thin-walled cylinder structure satisfying the requirements of actual working condition was design by using the energy absorption model of the classical cylinder shell under axial pressure. By using ABAQUS/explicit with J-C constitutive model, the finite element models of both the real reactor condition and the test condition were built to simulate the collision. Based on the analysis results, the control rod fall- down test was designed and implemented. The test results demonstrate that stable pro gressive buckling occurs when the full size buffer is impacted by equiponderance test bar, and the buffer can reduce the crush force effectively and protect the graphite from being destroyed. The analysis results show that the test model can represent and envelope the real condition in reactor. (authors)

  2. Development, analysis, and control of the inductor-converter bridge

    The inductor-converter bridge (ICB) is a solid state dc-ac-dc power converter system for bidirectional, controllable, energy transfer between two high Q magnet coils. The ICB is suitable for supplying large pulsed power to such magnets as the superconducting equilibrium field (EF) coil of the proposed tokamak power reactors, from another superconducting energy storage coil. This report presents work on the analysis and control of the ICB system. The process of energy transfer between the coils is explained on the basis of a simple one line equivalent circuit. This circuit is the topological dual of the one line diagram of the nonsalient pole synchoronous generator, connected to the infinite bus through its synchronous reactance. The changes in the average power, average coil currents, and voltages, as functions of time, are calculated by the conventional Fourier method of analysis

  3. Control room habitability Analysis and Testing for Wolsong Unit 1

    In response to this recommendation, KHNP has established CRH program and performed tracer gas in leakage tests. These activities are described herein including the emergency ventilation system analysis, acceptance criteria calculation for the test and Control Room Envelope (CRE) discrimination, and the results of the tracer gas tests are presented. CRH analysis including unfiltered in leakage tests according to the methodology in ASTM E741 was performed for Wolsong Unit 1. The results show that the integrity of the control room of Wolsong Unit 1 is in good condition to maintain the reactor in a safe condition under accident conditions, which complies with the US NRC regulatory guides 1.78, 1.196 and 1.197

  4. Control System Dynamics Analysis Of TRIGA Mark II Bandung

    The root locus analysis of TRIGA MARK II reactor was performed. The parameters were calculated based from the experimental data. The experiment was performed between 100 kW to 1 MW of power, average fuel temperature was 189oC and water average temperature was 37.3oC to measure temperature and xenon poisoning feedback. On the design analysis of PID system the characteristic of the controller are gain K=2.72, tp=13.65 seconds, Mp=0.0075%, Ti=4.1 seconds and Td=0.24 seconds. The controller transient time is less than 30 seconds and the settling time is less than 2% as well

  5. An analysis of neural models for walking control.

    Reeve, Richard; Hallam, John

    2005-05-01

    A large space of different neural models exists from simple mathematical abstractions to detailed biophysical representations with strongly differing levels of complexity and biological relevance. Previous comparisons between models have looked at biological realism or mathematical tractability rather than expressive power. This paper, however, investigates whether more sophisticated models are better suited to a complex sensorimotor control task than simpler ones, or whether the more general nature of groups of the simpler neurons allows them to collectively solve complex tasks better despite their individual simplicity. Many models have been proposed or used for sensorimotor control tasks such as the control of locomotion. Four such neural models with varying levels of complexity were chosen. Controllers made of networks of each neural type were evolved to generate locomotion in a simulated dynamically stable four-legged robot using a genetic algorithm. The problem domain was chosen as one for which no simple solution could be hand crafted and which, with its tight sensorimotor coupling, had strongly time-dependent properties as is common in many biological control tasks. Analysis of the results shows that the most complex and biologically based model is significantly better at walking control, even producing recognizable gaits. PMID:15941000

  6. Multilayer FeRh/MgO: controllable magnetocrystalline anisotropy for an antiferromagnetic system

    Zheng, Guohui; Dorj, Odkhuu; Ke, Sanhuang; Ramesh, Rammoorthy; Miao, Maosheng; Kioussis, Nickolas

    2015-03-01

    Controlling the magnetocrystalline anisotropy (MCA) of ferromagnetic (FM) thin films by tunable strain and electric field has been pursued as an effective method of achieving low-power and highly scalable memory. Comparing with FM materials, AFM are much less sensitive to external magnetic field, a substantial advantage for memory devices. Inspired by recent work on AFM memory resistors based on FeRh, we carried out a systematic first principles study of the MCA of multi-layer FeRh, either stand alone, or combined with MgO layers. FeRh is a unique material that undergoes a transition from AFM (type-II) to FM at elevated temperature of 370 K. Our calculations for thin films of FeRh from 5-15 atomic layers reveal that AFM is always the most stable configuration for Fe terminated films; while for Rh terminated films, there is a transition from FM to a configuration featured AFM at the center layers and FM at the surface layers (reconstructed). While applying the spin-orbit interactions (SOI) for the valence electrons, we found Fe-terminated films exhibit a relatively small MCA that varies and may change sign with film thickness, substrate and strain, providing a possibility of spin reorientation via the control of strain and electric field. The k-resolved MCA values reveals that the region around Gamma point adds the major contribution to the MCA.

  7. Model analysis and nonlinear control of air compressors

    Sari, Gholam-Reza

    For decades, gas turbines have been important, widespread, and reliable devices in the field of power generation, petrochemical industry, and aeronautics. They employ centrifugal and axial compressors which suffer from aerodynamic instabilities, namely, surge and rotating stall. These performance limiting instabilities can cause component stress, lifespan reduction, noise, and vibration. Furthermore, in variable speed axial compressors (VSACs), speed variations affect the system stability and can lead to surge and rotating stall. This limits the rate of speed variations and results in important performance penalties. The present work firstly addresses the bifurcation analysis of VSACs' model to investigate the impact of speed dynamics on the stability of efficient operating points. Here, the rate of speed variations (acceleration rate) is defined as a new parameter of the model and a detailed numerical bifurcation analysis is provided. The results of time-domain simulations not only validate the results of bifurcation analysis, but also broaden our knowledge about the transient response of the model, which is a matter of importance as well. The analysis reveals that speed variations can lead to a fully developed rotating stall as well as the previously reported temporary stall developments. The results show that the developed instabilities depend to a great extent on the acceleration rate. The impact of other key issues such as throttle gain, viscosity factor, initial speed, final speed, and the contribution of stall modes are also explored. From the control point of view, despite reported achievements, robust control design for compression systems remains a challenging problem. In this work, at first, two nonlinear approaches are proposed to tackle the stability problem of constant-speed axial compressors (CSACs). The first approach is a robust passivity-based control and the second one is a second order sliding mode control. The approaches tackle the challenging

  8. A Complete Analysis for Pump Controlled Single Rod Actuators

    Çalışkan,Hakan; Balkan, Tuna; Platin, Bülent E.

    2016-01-01

    In the current study a variable speed pump controlled hydrostatic circuit where an underlapped shuttle valve is utilized to compensate the unequal flow rate of a single rod actuator is analyzed. Parameters of the shuttle valve are included in the system analysis, rather than treating it as an ideal switching element as handled in literature. A linearized model of the system is obtained. An inverse kinematic model, which calculates the required pump drive speed for a desired actuator speed and...

  9. Interference control in low-level analysis of iodine 129

    This work analyses the integration of several steps applied to control potentials sources of error in the determination of 129I and prevent spurious results in order to achieve the minimum detection limit. The procedure of pre and post-irradiation purification, neutron irradiation, radioactive counting and data analysis are needed. High resolution gamma spectrometry was used for detection and measurement of low level interferences. (author)

  10. Electrical Power Distribution and Control Modeling and Analysis

    Fu, Johnny S.; Liffring, Mark; Mehdi, Ishaque S.

    2001-01-01

    This slide presentation reviews the use of Electrical Power Distribution and Control (EPD&C) Modeling and how modeling can support analysis. The presentation discusses using the EASY5 model to simulate and analyze the Space Shuttle Electric Auxiliary Power Unit. Diagrams of the model schematics are included, as well as graphs of the battery cell impedance, hydraulic load dynamics, and EPD&C response to hydraulic load variations.