Gold nanoparticle-assisted primer walking for closing the human chromosomal gap
Li, H; Shi, B; Li, X;
2013-01-01
NPs) to improve the efficiency in primer walking amplification. We used this strategy to close a gap in human chromosome 5 containing a DNA stretch composed of the 12SAT repeat. The obtained gap sequence is highly conserved among several mammalian genomes. The demonstrated AuNP-assisted primer walking strategy...
Single nucleotide polymorphism discovery of Pinus radiata with chromosome walking PCR method
Wei LI; Hui LI; Xiaoyang CHEN; Harry WU
2008-01-01
In this paper, the basic principle of chromosome walking is presented and we used an actin gene of radiata pine (Pinus radiata) as an example to conduct upstream and downstream chromosome walking for EST sequences. The full genomic sequence (2154 bp) of the actin gene, including promoters 5' UTR, CDS and 3' UTR, was identified by chromosome walking. PCR amplification and DNA band sequencing from 200 unrelated radiata pine trees revealed a total of 21 SNPs for the actin gene, three in the promoter region, 15 in CDS and 4 in 3' UTR. The results of this experiment provide a technical framework for SNPs dis-covery in none coding regions of candidate genes.
Yuanxin, Yan; Chengcai, An; Li, Li; Jiayu, Gu; Guihong, Tan; Zhangliang, Chen
2003-01-01
Dozens of PCR-based methods are available for chromosome walking from a known sequence to an unknown region. These methods are of three types: inverse PCR, ligation-mediated PCR and randomly primed PCR. However, none of them has been generally applied for this purpose, because they are either difficult or inefficient. Here we describe a simple and efficient PCR strategy—T-linker-specific ligation PCR (T-linker PCR) for gene or chromosome walking. The strategy amplifies the template molecules ...
Tracembler – software for in-silico chromosome walking in unassembled genomes
Wilkerson Matthew D
2007-05-01
Full Text Available Abstract Background Whole genome shotgun sequencing produces increasingly higher coverage of a genome with random sequence reads. Progressive whole genome assembly and eventual finishing sequencing is a process that typically takes several years for large eukaryotic genomes. In the interim, all sequence reads of public sequencing projects are made available in repositories such as the NCBI Trace Archive. For a particular locus, sequencing coverage may be high enough early on to produce a reliable local genome assembly. We have developed software, Tracembler, that facilitates in silico chromosome walking by recursively assembling reads of a selected species from the NCBI Trace Archive starting with reads that significantly match sequence seeds supplied by the user. Results Tracembler takes one or multiple DNA or protein sequence(s as input to the NCBI Trace Archive BLAST engine to identify matching sequence reads from a species of interest. The BLAST searches are carried out recursively such that BLAST matching sequences identified in previous rounds of searches are used as new queries in subsequent rounds of BLAST searches. The recursive BLAST search stops when either no more new matching sequences are found, a given maximal number of queries is exhausted, or a specified maximum number of rounds of recursion is reached. All the BLAST matching sequences are then assembled into contigs based on significant sequence overlaps using the CAP3 program. We demonstrate the validity of the concept and software implementation with an example of successfully recovering a full-length Chrm2 gene as well as its upstream and downstream genomic regions from Rattus norvegicus reads. In a second example, a query with two adjacent Medicago truncatula genes as seeds resulted in a contig that likely identifies the microsyntenic homologous soybean locus. Conclusion Tracembler streamlines the process of recursive database searches, sequence assembly, and gene
2007-01-01
Long terminal repeat (LTR) retrotransposons are powerful tools for studying genetic biodiversity,genome evolution, gene mutation, gene cloning and gene expression. The scarcity of retrotransposon sequence information restricts the development of these studies in higher plants. In the present study, 31 reverse transcriptase (RT) genes of Tyl-copia-like retrotransposons were identified from the apple genome by amplifying the RT coding region using degenerate primers. Nineteen RT genes showed extreme heterogeneity in terms of fragment size, base pair composition and open reading frame integrality. Originating from one 266 bp cloned RT gene, a 1966 bp Ty1-copia-like retrotransposon (named Tcrm1), including RT-ribonuclease H-LTR domain sequences, was achieved by chromosome walking based on modified SiteFinding-polymerase chain reaction. The comparison between Tcrm1 and other LTR retrotransposons in gene structure and sequence homology shows that Tcrm1 is the first Ty1-copia-like retrotransposon including an LTR domain in the apple genome. Dot blot analysis revealed that Tcrm1 copy number in the apple was approximately 1×103 copies per haploid genome.
A gene bank of Agrobacterium tumefaciens D286 wt has been constructed by cloning D286 wt DNA partially digested with EcoRI in the cosmid vector pLAFRI. The library; composed of 1750 members with a 27.7 kb average insert size was probed with pCDTn5-3, a cosmid vector carrying a D286:: Tn5 insert from the strain D286:: Tn5 Ag-. One recombinant cosmid of the library, pCDO932, was detected. The insert DNA of pCDO932 has sequences homologous to the D286:: Tn5 insert of pCDTn5-3, therefore it carries putative wt agrocin D286 genes. The insert DNA of pCDO932 was isolated and used to probe the D286 wt gene library. Chromosome walking resulted in the detection of pCD2375. EcoRI restriction digestions and DNA homology studies of pCDO932 and pCD2375 showed that their D286 wt inserts are both composed of 4 EcoRI DNA sub-fragments totalling 21.8 and 24.8 kb respectively, with an overlapping sequence extending 3.5 kb. In order to overcome the failure to detect A. tumefaciens cells transformed with pCDO932. Vectors pSUP204-1 was constructed. Such vector has been derived from pSUP204 which were slightly altered by cloning into it a 700 bp λ DNA SalI fragmet. This resulted in insertion inactivation of the Tcr gene, allows the use of pSUP204-1 as a subcloning vector in conjugations and transformations involving pCDO932 or pCD2375 and strains D286:: Tn5 Ag- and C58 C1G. Two recombinant cosmids bearing D286 wt DNA inserts, at least one of which (pCDO932) contains DNA sequences putatively affecting agrocin D286 production, are now available for further genetic manipulations. pSUP204-1 should prove useful as a subcloning vector for transformations and conjugations involving recombinant cosmids from the D286 wt gene bank and Agrobacterium strains. Future work on the molecular biology of agrocin D286 production is discussed. The DNA probe used in this study was labelled with phosphorus 32
... safety reasons, especially on uneven ground. See a physical therapist for exercise therapy and walking retraining. For a ... the right position for standing and walking. A physical therapist can supply these and provide exercise therapy, if ...
Complementarity and quantum walks
We show that quantum walks interpolate between a coherent 'wave walk' and a random walk depending on how strongly the walker's coin state is measured; i.e., the quantum walk exhibits the quintessentially quantum property of complementarity, which is manifested as a tradeoff between knowledge of which path the walker takes vs the sharpness of the interference pattern. A physical implementation of a quantum walk (the quantum quincunx) should thus have an identifiable walker and the capacity to demonstrate the interpolation between wave walk and random walk depending on the strength of measurement
Willey, David
2010-01-01
This article gives a brief history of fire-walking and then deals with the physics behind fire-walking. The author has performed approximately 50 fire-walks, took the data for the world's hottest fire-walk and was, at one time, a world record holder for the longest fire-walk (www.dwilley.com/HDATLTW/Record_Making_Firewalks.html). He currently…
Randomized random walk on a random walk
This paper discusses generalizations of the model introduced by Kehr and Kunter of the random walk of a particle on a one-dimensional chain which in turn has been constructed by a random walk procedure. The superimposed random walk is randomised in time according to the occurrences of a stochastic point process. The probability of finding the particle in a particular position at a certain instant is obtained explicitly in the transform domain. It is found that the asymptotic behaviour for large time of the mean-square displacement of the particle depends critically on the assumed structure of the basic random walk, giving a diffusion-like term for an asymmetric walk or a square root law if the walk is symmetric. Many results are obtained in closed form for the Poisson process case, and these agree with those given previously by Kehr and Kunter. (author)
Kendon, Viv
2011-01-01
Quantum versions of random walks have diverse applications that are motivating experimental implementations as well as theoretical studies. However, the main impetus behind this interest is their use in quantum algorithms, which have always employed the quantum walk in the form of a program running on a quantum computer. Recent results showing that quantum walks are "universal for quantum computation" relate entirely to algorithms, and do not imply that a physical quantum walk could provide a...
Mason, Nick
2007-01-01
A generation ago, it was part of growing up for all kids when they biked or walked to school. But in the last 30 years, heavier traffic, wider roads and more dangerous intersections have made it riskier for students walking or pedaling. Today, fewer than 15 percent of kids bike or walk to school compared with more than 50 percent in 1969. In the…
Kendon, Viv [School of Physics and Astronomy, University of Leeds, LS2 9JT (United Kingdom)
2014-12-04
Quantum versions of random walks have diverse applications that are motivating experimental implementations as well as theoretical studies. Recent results showing quantum walks are “universal for quantum computation” relate to algorithms, to be run on quantum computers. We consider whether an experimental implementation of a quantum walk could provide useful computation before we have a universal quantum computer.
WU An-Cai; XU Xin-Jian; WU Zhi-Xi; WANG Ying-Hai
2007-01-01
We investigate the dynamics of random walks on weighted networks. Assuming that the edge weight and the node strength are used as local information by a random walker. Two kinds of walks, weight-dependent walk and strength-dependent walk, are studied. Exact expressions for stationary distribution and average return time are derived and confirmed by computer simulations. The distribution of average return time and the mean-square that a weight-dependent walker can arrive at a new territory more easily than a strength-dependent one.
2012-07-31
This podcast is based on the August 2012 CDC Vital Signs report. While more adults are walking, only half get the recommended amount of physical activity. Listen to learn how communities, employers, and individuals may help increase walking. Created: 7/31/2012 by Centers for Disease Control and Prevention (CDC). Date Released: 8/7/2012.
Dertien, Edwin
2006-01-01
This paper describes the design and construction of Dribbel, a passivity-based walking robot. Dribbel has been designed and built at the Control Engineering group of the University of Twente. This paper focuses on the practical side: the design approach, construction, electronics, and software design. After a short introduction of dynamic walking, the design process, starting with simulation, is discussed.
Camilleri, Elizabeth; Rohde, Peter P.; Twamley, Jason
2014-01-01
Quantum walks exhibit many unique characteristics compared to classical random walks. In the classical setting, self-avoiding random walks have been studied as a variation on the usual classical random walk. Classical self-avoiding random walks have found numerous applications, most notably in the modeling of protein folding. We consider the analogous problem in the quantum setting. We complement a quantum walk with a memory register that records where the walker has previously resided. The w...
Kokshenev, V B
2004-01-01
The problem of biped locomotion at steady speeds is discussed through the Lagrangian formulation developed for velocity-dependent, body driving forces. Human walking on a level surface is analyzed in terms of the data on the resultant ground-reaction force and the external work. It is shown that the trajectory of the human center of mass is due to a superposition of its rectilinear motion with a given speed V and a backward rotation along a shortened hypocycloid. A stiff-to-compliant crossover between walking gaits is established at mid speeds, which separate slow walking from fast walking, limited by V_{\\max}=3.4 m/s. Key words: locomotion, bipedalism, human, biomechanics, walking.
Cavagna, G. A.; Willems, P. A.; Heglund, N. C.
1998-06-01
Sometime in the near future humans may walk in the reduced gravity of Mars. Gravity plays an essential role in walking. On Earth, the body uses gravity to `fall forwards' at each step and then the forward speed is used to restore the initial height in a pendulum-like mechanism. When gravity is reduced, as on the Moon or Mars, the mechanism of walking must change. Here we investigate the mechanics of walking on Mars onboard an aircraft undergoing gravity-reducing flight profiles. The optimal walking speed on Mars will be 3.4 km h-1 (down from 5.5 km h-1 on Earth) and the work done per unit distance to move the centre of mass will be half that on Earth.
Quantum walks on simplicial complexes
Matsue, Kaname; Ogurisu, Osamu; Segawa, Etsuo
2016-05-01
We construct a new type of quantum walks on simplicial complexes as a natural extension of the well-known Szegedy walk on graphs. One can numerically observe that our proposing quantum walks possess linear spreading and localization as in the case of the Grover walk on lattices. Moreover, our numerical simulation suggests that localization of our quantum walks reflects not only topological but also geometric structures. On the other hand, our proposing quantum walk contains an intrinsic problem concerning exhibition of non-trivial behavior, which is not seen in typical quantum walks such as Grover walks on graphs.
Biomechanical analysis of rollator walking
Alkjaer, T; Larsen, Peter K; Pedersen, Gitte;
2006-01-01
The rollator is a very popular walking aid. However, knowledge about how a rollator affects the walking patterns is limited. Thus, the purpose of the study was to investigate the biomechanical effects of walking with and without a rollator on the walking pattern in healthy subjects.......The rollator is a very popular walking aid. However, knowledge about how a rollator affects the walking patterns is limited. Thus, the purpose of the study was to investigate the biomechanical effects of walking with and without a rollator on the walking pattern in healthy subjects....
Durhuus, B; Wheater, J; Durhuus, Bergfinnur; Jonsson, Thordur; Wheater, John
2006-01-01
We develop techniques to obtain rigorous bounds on the behaviour of random walks on combs. Using these bounds we calculate exactly the spectral dimension of random combs with infinite teeth at random positions or teeth with random but finite length. We also calculate exactly the spectral dimension of some fixed non-translationally invariant combs. We relate the spectral dimension to the critical exponent of the mass of the two-point function for random walks on random combs, and compute mean displacements as a function of walk duration. We prove that the mean first passage time is generally infinite for combs with anomalous spectral dimension.
Quantum graph walks I: mapping to quantum walks
Higuchi, Yusuke; Konno, Norio; Sato, Iwao; Segawa, Etsuo
2012-01-01
We clarify that coined quantum walk is determined by only the choice of local quantum coins. To do so, we characterize coined quantum walks on graph by disjoint Euler circles with respect to symmetric arcs. In this paper, we introduce a new class of coined quantum walk by a special choice of quantum coins determined by corresponding quantum graph, called quantum graph walk. We show that a stationary state of quantum graph walk describes the eigenfunction of the quantum graph.
Chromosomal aberrations are classified into two types, chromosome-type and chromatid-type. Chromosom-type aberrations include terminal deletion, dicentric, ring and interstitial deletion, and chromatid-type aberrations include achromatic lesion, chromatid deletion, isochromatid deletion and chromatid exchange. Clastogens which induce chromosomal aberration are divided into ''S-dependent'' agents and ''S-independent''. It might mean whether they can induce double strand breaks independent of the S phase or not. Double strand breaks may be the ultimate lesions to induce chromosomal aberrations. Caffeine added even in the G2 phase appeared to modify the frequency of chromatid aberrations induced by X-rays and mitomycin C. Those might suggest that the G2 phase involves in the chromatid aberration formation. The double strand breaks might be repaired by ''G2 repair system'', the error of which might yield breakage types of chromatid aberrations and the by-pass of which might yield chromatid exchanges. Chromosome-type aberrations might be formed in the G1 phase. (author)
Usherwood, James Richard
2005-01-01
Bipedal walking following inverted pendulum mechanics is constrained by two requirements: sufficient kinetic energy for the vault over midstance and sufficient gravity to provide the centripetal acceleration required for the arc of the body about the stance foot. While the acceleration condition identifies a maximum walking speed at a Froude number of 1, empirical observation indicates favoured walk–run transition speeds at a Froude number around 0.5 for birds, humans and humans under manipul...
Schindler, Daniel; Waldminghaus, Torsten
2015-11-01
What a living organism looks like and how it works and what are its components-all this is encoded on DNA, the genetic blueprint. Consequently, the way to change an organism is to change its genetic information. Since the first pieces of recombinant DNA have been used to transform cells in the 1970s, this approach has been enormously extended. Bigger and bigger parts of the genetic information have been exchanged or added over the years. Now we are at a point where the construction of entire chromosomes becomes a reachable goal and first examples appear. This development leads to fundamental new questions, for example, about what is possible and desirable to build or what construction rules one needs to follow when building synthetic chromosomes. Here we review the recent progress in the field, discuss current challenges and speculate on the appearance of future synthetic chromosomes. PMID:26111960
Unitary equivalence of quantum walks
Highlights: • We have found unitary equivalent classes in coined quantum walks. • A single parameter family of coin operators is sufficient to realize all simple one-dimensional quantum walks. • Electric quantum walks are unitarily equivalent to time dependent quantum walks. - Abstract: A simple coined quantum walk in one dimension can be characterized by a SU(2) operator with three parameters which represents the coin toss. However, different such coin toss operators lead to equivalent dynamics of the quantum walker. In this manuscript we present the unitary equivalence classes of quantum walks and show that all the nonequivalent quantum walks can be distinguished by a single parameter. Moreover, we argue that the electric quantum walks are equivalent to quantum walks with time dependent coin toss operator
Biomechanical conditions of walking
Fan, Y F; Luo, L P; Li, Z Y; Han, S Y; Lv, C S; Zhang, B
2015-01-01
The development of rehabilitation training program for lower limb injury does not usually include gait pattern design. This paper introduced a gait pattern design by using equations (conditions of walking). Following the requirements of reducing force to the injured side to avoid further injury, we developed a lower limb gait pattern to shorten the stride length so as to reduce walking speed, to delay the stance phase of the uninjured side and to reduce step length of the uninjured side. This gait pattern was then verified by the practice of a rehabilitation training of an Achilles tendon rupture patient, whose two-year rehabilitation training (with 24 tests) has proven that this pattern worked as intended. This indicates that rehabilitation training program for lower limb injury can rest on biomechanical conditions of walking based on experimental evidence.
Vestergaard, Maria Quvang Harck; Olesen, Mette; Helmer, Pernille Falborg
2014-01-01
’ of mobility (Jensen 2013:111) such as the urban environment, and the infrastructures. Walking has indeed also a ‘software dimension’ as an embodied performance that trigger the human senses (Jensen 2013) and which is closely related to the habitus and identity of the individual (Halprin 1963). The...... individual perception of ‘walkability’ is based upon a subjective judgement of different physical factors, such as sidewalk width, traffic volumes and building height (Ewing and Handy 2009:67). And iIn order to understand the act of walking it is therefore necessary to create a vocabulary to understand how...... and why the individuals evaluate, interpret and act (Bourdieu 1984), and how this affects their choice to walk. Therefore it could be questioned if whether an assessment of the physical environment is sufficient to identify all the factors that influence the individual perception of ‘walkability’, or...
Clisby, Nathan
2013-01-01
We introduce a self-avoiding walk model for which end-effects are completely eliminated. We enumerate the number of these walks for various lattices in dimensions two and three, and use these enumerations to study the properties of this model. We find that endless self-avoiding walks have the same connective constant as self-avoiding walks, and the same Flory exponent $\
Walking and Sensing Mobile Lives
Bødker, Mads; Meinhardt, Nina Dam
In this position paper, we discuss how mindful walking with people allow us to explore sensory aspects of mobile lives that are typically absent from research. We present an app that aids researchers collect impressions from a walk.......In this position paper, we discuss how mindful walking with people allow us to explore sensory aspects of mobile lives that are typically absent from research. We present an app that aids researchers collect impressions from a walk....
Walking - Sensing - Participation
Bødker, Mads; Meinhardt, Nina Dam; Browning, David
Building on ethnographic research and social theory in the field of ‘mobilities’, this workshop paper suggests that field work based on simply walking with people entails a form of embodied participation that informs technological interventions by creating a space within which to address a wider...
Rasmussen, Mattias Borg
2014-01-01
Steep slopes, white peaks and deep valleys make up the Andes. As phenomenologists of landscape have told us, different people have different landscapes. By moving across the terrain, walking along, we might get a sense of how this has been carved out by the movement of wind and water, tectonics...
Bødker, Mads; Browning, David; Meinhardt, Nina Dam
We suggest that ‘walking’ in ethnographic work sensitizes researchers to a particular means of making sense of place. Following a brief conceptual exposition, we present our research tool iMaCam) that supports capturing and representing activities such as walking....
Frandsen, Mads Toudal
2007-01-01
I report on our construction and analysis of the effective low energy Lagrangian for the Minimal Walking Technicolor (MWT) model. The parameters of the effective Lagrangian are constrained by imposing modified Weinberg sum rules and by imposing a value for the S parameter estimated from the...
Cooper, Colin; Frieze, Alan
The aim of this article is to discuss some of the notions and applications of random walks on finite graphs, especially as they apply to random graphs. In this section we give some basic definitions, in Section 2 we review applications of random walks in computer science, and in Section 3 we focus on walks in random graphs.
Anthony J. Guttmann
2008-09-01
Full Text Available We have produced extended series for prudent self-avoiding walks on the square lattice. These are subsets of self-avoiding walks. We conjecture the exact growth constant and critical exponent for the walks, and show that the (anisotropic generating function is almost certainly not differentiably-finite.
Guttmann, Anthony J.; Dethridge, John C.
2008-01-01
We have produced extended series for prudent self-avoiding walks on the square lattice. These are subsets of self-avoiding walks. We conjecture the exact growth constant and critical exponent for the walks, and show that the (anisotropic) generating function is almost certainly not differentiably-finite.
Anderson, Sharon
2016-01-01
Over the last half century, knowledge about genetics, genetic testing, and its complexity has flourished. Completion of the Human Genome Project provided a foundation upon which the accuracy of genetics, genomics, and integration of bioinformatics knowledge and testing has grown exponentially. What is lagging, however, are efforts to reach and engage nurses about this rapidly changing field. The purpose of this article is to familiarize nurses with several frequently ordered genetic tests including chromosomes and fluorescence in situ hybridization followed by a comprehensive review of chromosome microarray. It shares the complexity of microarray including how testing is performed and results analyzed. A case report demonstrates how this technology is applied in clinical practice and reveals benefits and limitations of this scientific and bioinformatics genetic technology. Clinical implications for maternal-child nurses across practice levels are discussed. PMID:27276104
[Walking abnormalities in children].
Segawa, Masaya
2010-11-01
Walking is a spontaneous movement termed locomotion that is promoted by activation of antigravity muscles by serotonergic (5HT) neurons. Development of antigravity activity follows 3 developmental epochs of the sleep-wake (S-W) cycle and is modulated by particular 5HT neurons in each epoch. Activation of antigravity activities occurs in the first epoch (around the age of 3 to 4 months) as restriction of atonia in rapid eye movement (REM) stage and development of circadian S-W cycle. These activities strengthen in the second epoch, with modulation of day-time sleep and induction of crawling around the age of 8 months and induction of walking by 1 year. Around the age of 1 year 6 months, absence of guarded walking and interlimb cordination is observed along with modulation of day-time sleep to once in the afternoon. Bipedal walking in upright position occurs in the third epoch, with development of a biphasic S-W cycle by the age of 4-5 years. Patients with infantile autism (IA), Rett syndrome (RTT), or Tourette syndrome (TS) show failure in the development of the first, second, or third epoch, respectively. Patients with IA fail to develop interlimb coordination; those with RTT, crawling and walking; and those with TS, walking in upright posture. Basic pathophysiology underlying these condition is failure in restricting atonia in REM stage; this induces dysfunction of the pedunculopontine nucleus and consequently dys- or hypofunction of the dopamine (DA) neurons. DA hypofunction in the developing brain, associated with compensatory upward regulation of the DA receptors causes psychobehavioral disorders in infancy (IA), failure in synaptogenesis in the frontal cortex and functional development of the motor and associate cortexes in late infancy through the basal ganglia (RTT), and failure in functional development of the prefrontal cortex through the basal ganglia (TS). Further, locomotion failure in early childhood causes failure in development of functional
Fractional random walk lattice dynamics
Michelitsch, Thomas; Riascos, Alejandro Perez; Nowakowski, Andrzeij; Nicolleau, Franck
2016-01-01
We analyze time-discrete and continuous `fractional' random walks on undirected regular networks with special focus on cubic periodic lattices in $n=1,2,3,..$ dimensions.The fractional random walk dynamics is governed by a master equation involving {\\it fractional powers of Laplacian matrices $L^{\\frac{\\alpha}{2}}$}where $\\alpha=2$ recovers the normal walk.First we demonstrate thatthe interval $0\\textless{}\\alpha\\leq 2$ is admissible for the fractional random walk. We derive analytical expressions for fractional transition matrix and closely related the average return probabilities. We further obtain thefundamental matrix $Z^{(\\alpha)}$, and the mean relaxation time (Kemeny constant) for the fractional random walk.The representation for the fundamental matrix $Z^{(\\alpha)}$ relates fractional random walks with normal random walks.We show that the fractional transition matrix elements exihibit for large cubic $n$-dimensional lattices a power law decay of an $n$-dimensional infinite spaceRiesz fractional deriva...
Böttcher, S
1997-01-01
Aging refers to the property of two-time correlation functions to decay very slowly on (at least) two time scales. This phenomenon has gained recent attention due to experimental observations of the history dependent relaxation behavior in amorphous materials (``Glasses'') which pose a challenge to theorist. Aging signals the breaking of time-translational invariance and the violation of the fluctuation dissipation theorem during the relaxation process. But while the origin of aging in disordered media is profound, and the discussion is clad in the language of a well-developed theory, systems as simple as a random walk near a wall can exhibit aging. Such a simple walk serves well to illustrate the phenomenon and some of the physics behind it.
Fujie, Futaba
2014-01-01
Covering Walks in Graphs is aimed at researchers and graduate students in the graph theory community and provides a comprehensive treatment on measures of two well studied graphical properties, namely Hamiltonicity and traversability in graphs. This text looks into the famous Kӧnigsberg Bridge Problem, the Chinese Postman Problem, the Icosian Game and the Traveling Salesman Problem as well as well-known mathematicians who were involved in these problems. The concepts of different spanning walks with examples and present classical results on Hamiltonian numbers and upper Hamiltonian numbers of graphs are described; in some cases, the authors provide proofs of these results to illustrate the beauty and complexity of this area of research. Two new concepts of traceable numbers of graphs and traceable numbers of vertices of a graph which were inspired by and closely related to Hamiltonian numbers are introduced. Results are illustrated on these two concepts and the relationship between traceable concepts and...
Fitness Club
2015-01-01
Four classes of one hour each are held on Tuesdays. RDV barracks parking at Entrance A, 10 minutes before class time. Spring Course 2015: 05.05/12.05/19.05/26.05 Prices 40 CHF per session + 10 CHF club membership 5 CHF/hour pole rental Check out our schedule and enroll at: https://espace.cern.ch/club-fitness/Lists/Nordic%20Walking/NewForm.aspx? Hope to see you among us! fitness.club@cern.ch
Banderier, Cyril; Nicodeme, Pierre
2010-01-01
This article tackles the enumeration and asymptotics of directed lattice paths (that are isomorphic to unidimensional paths) of bounded height (walks below one wall, or between two walls, for \\emphany finite set of jumps). Thus, for any lattice paths, we give the generating functions of bridges (``discrete'' Brownian bridges) and reflected bridges (``discrete'' reflected Brownian bridges) of a given height. It is a new success of the ``kernel method'' that the generating functions of such wal...
Sugar, Thomas G.; Hollander, Kevin W.; Hitt, Joseph K.
2011-04-01
Developing bionic ankles poses great challenges due to the large moment, power, and energy that are required at the ankle. Researchers have added springs in series with a motor to reduce the peak power and energy requirements of a robotic ankle. We developed a "robotic tendon" that reduces the peak power by altering the required motor speed. By changing the required speed, the spring acts as a "load variable transmission." If a simple motor/gearbox solution is used, one walking step would require 38.8J and a peak motor power of 257 W. Using an optimized robotic tendon, the energy required is 21.2 J and the peak motor power is reduced to 96.6 W. We show that adding a passive spring in parallel with the robotic tendon reduces peak loads but the power and energy increase. Adding a passive spring in series with the robotic tendon reduces the energy requirements. We have built a prosthetic ankle SPARKy, Spring Ankle with Regenerative Kinetics, that allows a user to walk forwards, backwards, ascend and descend stairs, walk up and down slopes as well as jog.
Extendable self-avoiding walks
Grimmett, Geoffrey R.; Holroyd, Alexander E; Peres, Yuval
2013-01-01
The connective constant mu of a graph is the exponential growth rate of the number of n-step self-avoiding walks starting at a given vertex. A self-avoiding walk is said to be forward (respectively, backward) extendable if it may be extended forwards (respectively, backwards) to a singly infinite self-avoiding walk. It is called doubly extendable if it may be extended in both directions simultaneously to a doubly infinite self-avoiding walk. We prove that the connective constants for forward,...
Physical implementation of quantum walks
Manouchehri, Kia
2013-01-01
Given the extensive application of random walks in virtually every science related discipline, we may be at the threshold of yet another problem solving paradigm with the advent of quantum walks. Over the past decade, quantum walks have been explored for their non-intuitive dynamics, which may hold the key to radically new quantum algorithms. This growing interest has been paralleled by a flurry of research into how one can implement quantum walks in laboratories. This book presents numerous proposals as well as actual experiments for such a physical realization, underpinned by a wide range of
Persistence of random walk records
We study records generated by Brownian particles in one dimension. Specifically, we investigate an ordinary random walk and define the record as the maximal position of the walk. We compare the record of an individual random walk with the mean record, obtained as an average over infinitely many realizations. We term the walk ‘superior’ if the record is always above average, and conversely, the walk is said to be ‘inferior’ if the record is always below average. We find that the fraction of superior walks, S, decays algebraically with time, S ∼ t−β, in the limit t → ∞, and that the persistence exponent is nontrivial, β = 0.382 258…. The fraction of inferior walks, I, also decays as a power law, I ∼ t−α, but the persistence exponent is smaller, α = 0.241 608…. Both exponents are roots of transcendental equations involving the parabolic cylinder function. To obtain these theoretical results, we analyze the joint density of superior walks with a given record and position, while for inferior walks it suffices to study the density as a function of position. (paper)
Physical Map and Organization of Chromosome 7 in the Rice Blast Fungus, Magnaporthe grisea
Zhu, Heng; Blackmon, Barbara P.; Sasinowski, Maciek; Dean, Ralph A.
1999-01-01
The rice blast fungus Magnaporthe grisea is a highly destructive plant pathogen and one of the most important for studying various aspects of host-plant interactions. It has been widely adopted as a model organism because it is ideally suited for genetic and biological studies. To facilitate map-based cloning, chromosome walking, and genome organization studies of M. grisea, a complete physical map of chromosome 7 was constructed using a large-insert (130 kb) bacterial artificial chromosome (...
Walking. Sensing. Participation
Bødker, Mads
2014-01-01
This paper uses three meditations to contemplate walking, sensing and participation as three ways with which we can extend the notion of ‘experiential computing’ proposed by Yoo (2010). By using the form of meditations, loosely associated concepts that are part introspective and part ‘causative’, i...... intended to also inform the design of technologies for the future. By emphasizing the senses and the body and their importance to an extended notion of sensory apprenticeship (Pink, 2009), the paper suggests alternative routes to knowing and representation in IS related fieldwork....
Lawler, Gregory F.; Ferreras, José A. Trujillo
2004-01-01
The Brownian loop soup introduced in Lawler and Werner (2004) is a Poissonian realization from a sigma-finite measure on unrooted loops. This measure satisfies both conformal invariance and a restriction property. In this paper, we define a random walk loop soup and show that it converges to the Brownian loop soup. In fact, we give a strong approximation result making use of the strong approximation result of Koml\\'os, Major, and Tusn\\'ady. To make the paper self-contained, we include a proof...
Romanelli, Alejandro
2011-01-01
A thermodynamic theory is developed to describe the behavior of the entanglement between the coin and position degrees of freedom of the quantum walk on the line. This theory shows that, in spite of the unitary evolution, a steady state is established after a Markovian transient stage. This study suggests that if a quantum dynamics is developed in a composite Hilbert space (i.e. the tensor product of several sub-spaces) then the behavior of an operator that only belongs to one of the sub-spaces may camouflage the unitary character of the global evolution.
Woof, M.
2002-09-01
The article reports on the activity in the dragline sector which has been greater in the past 18 months than in previous years. One notable event is the recent order by BNI Coal in the USA of a large walking dragline, the Marion 8200 model from Bucyrus, for removal of overburden at the Center Mine in North Dakota. The Marison draglines have an oval rigid structure which provides an effective load and boom support. The article reports uses of other Bucyrus draglines in Canada and Australia. 2 figs.
Clisby, Nathan
2013-06-01
We introduce a self-avoiding walk model for which end-effects are completely eliminated. We enumerate the number of these walks for various lattices in dimensions two and three, and use these enumerations to study the properties of this model. We find that endless self-avoiding walks have the same connective constant as self-avoiding walks, and the same Flory exponent ν. However, there is no power law correction to the exponential number growth for this new model, i.e. the critical exponent γ = 1 exactly in any dimension. In addition, the number growth has no analytic corrections to scaling, and we have convincing numerical evidence to support the conjecture that the amplitude for the number growth is a universal quantity. The technique by which end-effects are eliminated may be generalized to other models of polymers such as interacting self-avoiding walks.
We introduce a self-avoiding walk model for which end-effects are completely eliminated. We enumerate the number of these walks for various lattices in dimensions two and three, and use these enumerations to study the properties of this model. We find that endless self-avoiding walks have the same connective constant as self-avoiding walks, and the same Flory exponent ν. However, there is no power law correction to the exponential number growth for this new model, i.e. the critical exponent γ = 1 exactly in any dimension. In addition, the number growth has no analytic corrections to scaling, and we have convincing numerical evidence to support the conjecture that the amplitude for the number growth is a universal quantity. The technique by which end-effects are eliminated may be generalized to other models of polymers such as interacting self-avoiding walks. (paper)
Quantum walks and search algorithms
Portugal, Renato
2013-01-01
This book addresses an interesting area of quantum computation called quantum walks, which play an important role in building quantum algorithms, in particular search algorithms. Quantum walks are the quantum analogue of classical random walks. It is known that quantum computers have great power for searching unsorted databases. This power extends to many kinds of searches, particularly to the problem of finding a specific location in a spatial layout, which can be modeled by a graph. The goal is to find a specific node knowing that the particle uses the edges to jump from one node to the next. This book is self-contained with main topics that include: Grover's algorithm, describing its geometrical interpretation and evolution by means of the spectral decomposition of the evolution operater Analytical solutions of quantum walks on important graphs like line, cycles, two-dimensional lattices, and hypercubes using Fourier transforms Quantum walks on generic graphs, describing methods to calculate the limiting d...
Mounting evidence is compiling linking the physical organizational structure of chromosomes and the nuclear structure to biological function. At the base of the physical organizational structure of both is the concept of loop formation. This implies that physical proximity within chromosomes is provided for otherwise distal genomic regions and thus hierarchically organizing the chromosomes. Together with entropy many experimental observations can be explained with these two concepts. Among the observations that can be explained are the measured physical extent of the chromosomes, their shape, mechanical behavior, the segregation into territories (chromosomal and territories within chromosomes), the results from chromosome conformation capture experiments, as well as linking gene expression to structural organization.
Comparison of heart rate responses. Water walking versus treadmill walking.
Whitley, J D; Schoene, L L
1987-10-01
The purpose of this study was to compare heart rate responses to water walking versus treadmill walking to determine whether the responses were of sufficient magnitude to elicit cardiorespiratory training effects. The heart rates of 12 healthy, female college students were measured immediately after walking in waist-deep water and on a treadmill at the same distance, durations, and speeds (2.55, 2.77, 3.02, and 3.31 km/hr). A significant increase in heart rate with increased speeds resulted from water walking (p less than .05); from rest to the fastest speed, it was 135% (96 bpm). For treadmill walking, the increase of 19% (13 bpm) was not significant. The heart rates for the water condition were significantly higher (p less than .05) at each speed. These findings indicate that water walking could serve as an effective exercise mode, for example, for cardiorespiratory fitness for individuals who are unable to perform such weight-bearing activities as jogging, fast walking, cycling, and dancing. PMID:3659133
Elena Grigoryeva
2011-08-01
Full Text Available It is noteworthy that this country develops through two types of events: either through a jubilee or through a catastrophe.It seems that Irkutsk Airport will be built only after the next crash. At least the interest to this problem returns regularly after sad events, and this occurs almost half a century (a jubilee, too! – the Council of Ministers decided to relocate the Airport away from the city as long ago as 1962. The Airport does not relate to the topic of this issue, but an attentive reader understands that it is our Carthage, and that the Airport should be relocated. The Romans coped with it faster and more effectively.Back to Irkutsk’s jubilee, we should say that we will do without blare of trumpets. We will just make an unpretentious walk around the city in its summer 350. Each our route covers new (some of them have been completed by the jubilee and old buildings, some of them real monuments. All these buildings are integrated into public spaces of different quality and age.We will also touch on the problems, for old houses, especially the wooden ones often provoke a greedy developer to demolish or to burn them down. Thus a primitive thrift estimates an output of additional square meters. Not to mention how attractive it is to seize public spaces without demolition or without reallocation of the dwellers. Or, rather, the one who is to preserve, to cherish and to improve such houses for the good of the citizens never speaks about this sensitive issue. So we have to do it.Walking is a no-hurry genre, unlike the preparation for the celebration. Walking around the city you like is a pleasant and cognitive process. It will acquaint the architects with the works of their predecessors and colleagues. We hope that such a walk may be interesting for Irkutsk citizens and visitors, too. Isn’t it interesting to learn “at first hand” the intimate details of the restoration of the Trubetskoys’ estate
2005-01-01
The man who compared himself to a proton ! On 20 May, Gianni Motti went down into the LHC tunnel and walked around the 27 kilometres of the underground ring at an average, unaccelerated pace of 5 kph. This was an artistic rather than an athletic performance, aimed at drawing a parallel between the fantastic speed of the beams produced by the future accelerator and the leisurely stroll of a human. The artist, who hails from Lombardy, was accompanied by cameraman Ivo Zanetti, who filmed the event from start to finish, and physicist Jean-Pierre Merlo. The first part of the film can be seen at the Villa Bernasconi, 8 route du Grand-Lancy, Grand Lancy, until 26 June.
2005-01-01
The man who compared himself to a proton ! On 20 May, Gianni Motti went down into the LHC tunnel and walked around the 27 kilometres of the underground ring at an average, unaccelerated pace of 5 kph. This was an artistic rather than an athletic performance, aimed at drawing a parallel between the fantastic speed of the beams produced by the future accelerator and the leisurely stroll of a human. The artist, who hails from Lombardy, was accompanied by cameraman Ivo Zanetti, who filmed the event from start to finish, and physicist Jean-Pierre Merlo. The first part of the film can be seen at the Villa Bernasconi, 8 route du Grand-Lancy, Grand Lancy, until 26 June.
Fetal chromosome analysis: screening for chromosome disease?
Philip, J; Tabor, Ann; Bang, J;
1983-01-01
A + B). Pregnant women 35 years of age, women who previously had a chromosomally abnormal child, families with translocation carriers or other heritable chromosomal disease, families where the father was 50 years or more and women in families with a history of Down's syndrome (group A), were...... unbalanced chromosome abnormality in group A (women with elevated risk) is significantly higher than in group B + C (women without elevated risk) (relative risk 2.4). Women with a known familial translocation and women 40 years or more have a relative risk of 5.7 of having an unbalanced chromosome......The aim of the study was to investigate the rationale of the current indications for fetal chromosome analysis. 5372 women had 5423 amniocentesis performed, this group constituting a consecutive sample at the chromosome laboratory, Rigshospitalet, Copenhagen from March 1973 to September 1980 (Group...
Walking Robot Locomotion System Conception
Ignatova D.
2014-09-01
Full Text Available This work is a brief analysis on the application and perspective of using the walking robots in different areas in practice. The most common characteristics of walking four legs robots are presented here. The specific features of the applied actuators in walking mechanisms are also shown in the article. The experience of Institute of Mechanics - BAS is illustrated in creation of Spiroid and Helicon1 gears and their assembly in actuation of studied robots. Loading on joints reductors of robot legs is modelled, when the geometrical and the walking parameters of the studied robot are preliminary defined. The obtained results are purposed for designing the control of the loading of reductor type Helicon in the legs of the robot, when it is experimentally tested.
Bill Phillips
2014-01-01
Full Text Available Monsters have always enjoyed a significant presence in the human imagination, and religion was instrumental in replacing the physical horror they engendered with that of a moral threat. Zombies, however, are amoral – their motivation purely instinctive and arbitrary, yet they are, perhaps, the most loathed of all contemporary monsters. One explanation for this lies in the theory of the uncanny valley, proposed by robotics engineer Masahiro Mori. According to the theory, we r eserve our greatest fears for those things which seem most human, yet are not – such as dead bodies. Such a reaction is most likely a survival mechanism to protect us from danger and disease – a mechanism even more essential when the dead rise up and walk. From their beginnings zombies have reflected western societies’ greatest fears – be they of revolutionary Haitians, women, or communists. In recent years the rise in the popularity of the zombie in films, books and television series reflects our fears for the planet, the economy, and of death itself.
Bill Phillips
2014-02-01
Full Text Available Monsters have always enjoyed a significant presence in the human imagination, and religion was instrumental in replacing the physical horror they engendered with that of a moral threat. Zombies, however, are amoral – their motivation purely instinctive and arbitrary, yet they are, perhaps, the most loathed of all contemporary monsters. One explanation for this lies in the theory of the uncanny valley, proposed by robotics engineer Masahiro Mori. According to the theory, we reserve our greatest fears for those things which seem most human, yet are not – such as dead bodies. Such a reaction is most likely a survival mechanism to protect us from danger and disease – a mechanism even more essential when the dead rise up and walk. From their beginnings zombies have reflected western societies’ greatest fears – be they of revolutionary Haitians, women, or communists. In recent years the rise in the popularity of the zombie in films, books and television series reflects our fears for the planet, the economy, and of death itself
Walking Behavior in Technicolored GUTs
Doff, A.(Universidade Tecnológica Federal do Paraná – UTFPR – DAFIS, Av. Monteiro Lobato Km 04, 84016-210 Ponta Grossa, PR, Brazil)
2009-01-01
There exist two ways to obtain walk behavior: assuming a large number of technifermions in the fundamental representation of the technicolor (TC) gauge group, or a small number of technifermions, assuming that these fermions are in higher-dimensional representations of the TC group. We propose a scheme to obtain the walking behavior based on technicolored GUTs (TGUTs), where elementary scalars with the TC degree of freedom may remain in the theory after the GUT symmetry breaking.
Identifying Emotion from Natural Walking
Cui, Liqing; Li, Shun; Zhang, Wan; Zhang, Zhan; Zhu, Tingshao
2015-01-01
Emotion identification from gait aims to automatically determine persons affective state, it has attracted a great deal of interests and offered immense potential value in action tendency, health care, psychological detection and human-computer(robot) interaction.In this paper, we propose a new method of identifying emotion from natural walking, and analyze the relevance between the traits of walking and affective states. After obtaining the pure acceleration data of wrist and ankle, we set a...
Chromosome painting in plants.
Schubert, I.; Fransz, P.F.; Fuchs, J.; Jong, de J.H.
2001-01-01
The current 'state-of-art' as to chromosome painting in plants is reviewed. We define different situations described as painting so far: i) Genomic in situ hybridisation (GISH) with total genomic DNA to distinguish alien chromosomes on the basis of divergent dispersed repeats, ii) 'Chromosomal in si
Plante, Ianik; Ponomarev, Artem L.; Wu, Honglu; Blattnig, Steve; George, Kerry
2014-01-01
The formation of DNA double-strand breaks (DSBs) and chromosome aberrations is an important consequence of ionizing radiation. To simulate DNA double-strand breaks and the formation of chromosome aberrations, we have recently merged the codes RITRACKS (Relativistic Ion Tracks) and NASARTI (NASA Radiation Track Image). The program RITRACKS is a stochastic code developed to simulate detailed event-by-event radiation track structure: [1] This code is used to calculate the dose in voxels of 20 nm, in a volume containing simulated chromosomes, [2] The number of tracks in the volume is calculated for each simulation by sampling a Poisson distribution, with the distribution parameter obtained from the irradiation dose, ion type and energy. The program NASARTI generates the chromosomes present in a cell nucleus by random walks of 20 nm, corresponding to the size of the dose voxels, [3] The generated chromosomes are located within domains which may intertwine, and [4] Each segment of the random walks corresponds to approx. 2,000 DNA base pairs. NASARTI uses pre-calculated dose at each voxel to calculate the probability of DNA damage at each random walk segment. Using the location of double-strand breaks, possible rejoining between damaged segments is evaluated. This yields various types of chromosomes aberrations, including deletions, inversions, exchanges, etc. By performing the calculations using various types of radiations, it will be possible to obtain relative biological effectiveness (RBE) values for several types of chromosome aberrations.
Chimpanzee chromosome 12 is homologous to human chromosome 2q
Sun, N. C.; Sun, C. R.Y.; Ho, T.
1977-01-01
Most of the 46 human chromosomes find their counterparts in the 48 chimpanzee chromosomes except for chromosome 2 which has been hypothesized to have been derived from a centric fusion of two chimpanzee acrocentric chromosomes. These two chromosomes correspond to the human chromosomes 2p and 2g. This conclusion is based primarily on chromosome banding techniques, and the somatic cell hybridization technique has also been used. (HLW)
Loci impacting polymorphic gait in the Tennessee Walking Horse.
Staiger, E A; Abri, M A; Silva, C A S; Brooks, S A
2016-04-01
Following domestication, man selected the horse primarily for the purpose of transportation rather than consumption; this selective strategy created divergent traits for locomotion. At intermediate speeds, beyond the flat walk, the horse can perform a range of diagonal and lateral 2-beat or 4-beat gait patterns. The Tennessee Walking Horse (TWH) is the only U.S. breed able to perform an even-timed 4-beat gait (the "running-walk") at intermediate speeds; however, within the breed, there is remaining variation in gait type. To investigate the contribution of genetics to this unique trait, blood or hair samples for DNA and gait information were collected from 129 TWH and genotyping was performed at approximately 60,000 loci using the Illumina Equine SNP70 beadchip at GeneSeek Inc. (Lincoln, NE). Case-control association tests identified suggestive regions for gait type on equine chromosome (ECA) 19 (-value of 1.50 × 10 after 1 million permutations; PLINK version 1.07). Haplotype analysis identified 2 significant haplotypes on ECA19 and ECA11 (-values of 3.7 × 10 and 3.92 × 10, respectively). Genes within these suggestive regions play roles in developmental processes and biological regulation, indicating there may be variant differences in the neurobiology and regulation of horses with a polymorphic gait. PMID:27135997
Minnesota Walk-In Access Sites
Minnesota Department of Natural Resources — The Minnesota Walk-In Access site (WIA) GIS data represents areas of private land that have been made open to the public for the purpose of walk-in (foot travel)...
Dissipative quantum computing with open quantum walks
Sinayskiy, Ilya; Petruccione, Francesco [National Institute for Theoretical Physics and Quantum Research Group, School of Chemistry and Physics, University of KwaZulu-Natal, Durban (South Africa)
2014-12-04
An open quantum walk approach to the implementation of a dissipative quantum computing scheme is presented. The formalism is demonstrated for the example of an open quantum walk implementation of a 3 qubit quantum circuit consisting of 10 gates.
Efficient quantum walk on a quantum processor
Qiang, Xiaogang; Loke, Thomas; Montanaro, Ashley; Aungskunsiri, Kanin; Zhou, Xiaoqi; O'Brien, Jeremy L.; Wang, Jingbo B.; Jonathan C. F. Matthews
2016-01-01
The random walk formalism is used across a wide range of applications, from modelling share prices to predicting population genetics. Likewise, quantum walks have shown much potential as a framework for developing new quantum algorithms. Here we present explicit efficient quantum circuits for implementing continuous-time quantum walks on the circulant class of graphs. These circuits allow us to sample from the output probability distributions of quantum walks on circulant graphs efficiently. ...
Common muscle synergies for balance and walking
Chvatal, Stacie A.; Ting, Lena H.
2013-01-01
Little is known about the integration of neural mechanisms for balance and locomotion. Muscle synergies have been studied independently in standing balance and walking, but not compared. Here, we hypothesized that reactive balance and walking are mediated by a common set of lower-limb muscle synergies. In humans, we examined muscle activity during multidirectional support-surface perturbations during standing and walking, as well as unperturbed walking at two speeds. We show that most muscle ...
Closed walks for community detection
Yang, Yang; Sun, Peng Gang; Hu, Xia; Li, Zhou Jun
2014-03-01
In this paper, we propose a novel measure that integrates both the concept of closed walks and clustering coefficients to replace the edge betweenness in the well-known divisive hierarchical clustering algorithm, the Girvan and Newman method (GN). The edges with the lowest value are removed iteratively until the network is degenerated into isolated nodes. The experimental results on computer generated networks and real-world networks showed that our method makes a better tradeoff of accuracy and runtime. Based on the analysis of the results, we observe that the nontrivial closed walks of order three and four can be considered as the basic elements in constructing community structures. Meanwhile, we discover that those nontrivial closed walks outperform trivial closed walks in the task of analyzing the structure of networks. The double peak structure problem is mentioned in the last part of the article. We find that our proposed method is a novel way to solve the double peak structure problem. Our work can provide us with a new perspective for understanding community structure in complex networks.
Amaral, M M; Irwin, Klee
2016-01-01
We apply a discrete quantum walk from a quantum particle on a discrete quantum spacetime from loop quantum gravity and show that the related Entanglement Entropy can drive a entropic force. We apply this concepts to propose a model of a walker position topologically encoded on a spin network.
Walking around to grasp interaction
Lykke, Marianne; Jantzen, Christian
2013-01-01
-alongs the research-ers acted as facilitators and partners in the engagement with the sound installa-tions. The study provided good insight into advantages and challenges with the walk-along method, for instance the importance of shared, embodied sensing of space for the understanding of the experience. The common...
Successful Statewide Walking Program Websites
Teran, Bianca Maria; Hongu, Nobuko
2012-01-01
Statewide Extension walking programs are making an effort to increase physical activity levels in America. An investigation of all 20 of these programs revealed that 14 use websites as marketing and educational tools, which could prove useful as the popularity of Internet communities continues to grow. Website usability information and an analysis…
Weir, Phil
1994-01-01
During a walk, an outdoor education teacher reflects on the status of outdoor education in Ottawa (Canada) and importance of maintaining a close relationship with nature. He looks for signs of an old log home site, observes a hawk's flight, discovers remains of a plastic bag in an owl pellet, and realizes that everyone is working on survival. (LP)
Adams, Luise; Weinzierl, Stefan
2016-01-01
A walk on sunset boulevard can teach us about transcendental functions associated to Feynman diagrams. On this guided tour we will see multiple polylogarithms, differential equations and elliptic curves. A highlight of the tour will be the generalisation of the polylogarithms to the elliptic setting and the all-order solution for the sunset integral in the equal mass case.
Physical map and organization of chromosome 7 in the rice blast fungus, Magnaporthe grisea.
Zhu, H; Blackmon, B P; Sasinowski, M; Dean, R A
1999-08-01
The rice blast fungus Magnaporthe grisea is a highly destructive plant pathogen and one of the most important for studying various aspects of host-plant interactions. It has been widely adopted as a model organism because it is ideally suited for genetic and biological studies. To facilitate map-based cloning, chromosome walking, and genome organization studies of M. grisea, a complete physical map of chromosome 7 was constructed using a large-insert (130 kb) bacterial artificial chromosome (BAC) library. Using 147 chromosome 7-specific single-copy BAC clones and 20 RFLP markers on chromosome 7, 625 BAC clones were identified by hybridization. BAC clones were digested with HindIII, and fragments were size separated on analytical agarose gels to create DNA fingerprints. Hybridization contigs were constructed using a random cost algorithm, whereas fingerprinting contigs were constructed using the software package FPC. Results from both methods were generally in agreement, but numerous anomalies were observed. The combined data produced five robust anchored contigs after gap closure by chromosomal walking. The genetic and physical maps agreed closely. The final physical map was estimated to cover >95% of the 4.2 Mb of chromosome 7. Based on the contig maps, a minimum BAC tile containing 42 BAC clones was created, and organization of repetitive elements and expressed genes of the chromosome was investigated. PMID:10447509
Numerical studies of planar closed random walks
Lattice numerical simulations for planar closed random walks and their winding sectors are presented. The frontiers of the random walks and of their winding sectors have a Hausdorff dimension dH = 4/3. However, when properly defined by taking into account the inner 0-winding sectors, the frontiers of the random walks have a Hausdorff dimension dH≈1.77
Plant sex chromosome evolution.
Charlesworth, Deborah
2013-01-01
It is now well established that plants have an important place in studies of sex chromosome evolution because of the repeated independent evolution of separate sexes and sex chromosomes. There has been considerable recent progress in studying plant sex chromosomes. In this review, I focus on how these recent studies have helped clarify or answer several important questions about sex chromosome evolution, and I shall also try to clarify some common misconceptions. I also outline future work that will be needed to make further progress, including testing some important ideas by genetic, molecular, and developmental approaches. Systems with different ages can clearly help show the time course of events during changes from an ancestral co-sexual state (hermaphroditism or monoecy), and I will also explain how different questions can be studied in lineages whose dioecy or sex chromosomes evolved at different times in the past. PMID:23125359
Vibrio chromosomes share common history
Gevers Dirk; Chang Sarah; Chang LeeAnn; Kirkup Benjamin C; Polz Martin F
2010-01-01
Abstract Background While most gamma proteobacteria have a single circular chromosome, Vibrionales have two circular chromosomes. Horizontal gene transfer is common among Vibrios, and in light of this genetic mobility, it is an open question to what extent the two chromosomes themselves share a common history since their formation. Results Single copy genes from each chromosome (142 genes from chromosome I and 42 genes from chromosome II) were identified from 19 sequenced Vibrionales genomes ...
Bru, Luis A; Di Molfetta, Giuseppe; Pérez, Armando; Roldán, Eugenio; Silva, Fernando
2016-01-01
We consider the 2D alternate quantum walk on a cylinder. We concentrate on the study of the motion along the open dimension, in the spirit of looking at the closed coordinate as a small or "hidden" extra dimension. If one starts from localized initial conditions on the lattice, the dynamics of the quantum walk that is obtained after tracing out the small dimension shows the contribution of several components, which can be understood from the study of the dispersion relations for this problem. In fact, these components originate from the contribution of the possible values of the quasi-momentum in the closed dimension. In the continuous space-time limit, the different components manifest as a set of Dirac equations, with each quasi-momentum providing the value of the corresponding mass. We briefly discuss the possible link of these ideas to the simulation of high energy physical theories that include extra dimensions.
Stable walking with asymmetric legs
Asymmetric leg function is often an undesired side-effect in artificial legged systems and may reflect functional deficits or variations in the mechanical construction. It can also be found in legged locomotion in humans and animals such as after an accident or in specific gait patterns. So far, it is not clear to what extent differences in the leg function of contralateral limbs can be tolerated during walking or running. Here, we address this issue using a bipedal spring-mass model for simulating walking with compliant legs. With the help of the model, we show that considerable differences between contralateral legs can be tolerated and may even provide advantages to the robustness of the system dynamics. A better understanding of the mechanisms and potential benefits of asymmetric leg operation may help to guide the development of artificial limbs or the design novel therapeutic concepts and rehabilitation strategies.
City Walks and Tactile Experience
Mădălina Diaconu
2011-01-01
Full Text Available This paper is an attempt to develop categories of the pedestrian’s tactile and kinaesthetic experience of the city. The beginning emphasizes the haptic qualities of surfaces and textures, which can be “palpated” visually or experienced by walking. Also the lived city is three-dimensional; its corporeal depth is discussed here in relation to the invisible sewers, protuberant profiles, and the formal diversity of roofscapes. A central role is ascribed in the present analysis to the formal similarities between the representation of the city by walking through it and the representation of the tactile form of objects. Additional aspects of the “tactile” experience of the city in a broad sense concern the feeling of their rhythms and the exposure to weather conditions. Finally, several aspects of contingency converge in the visible age of architectural works, which record traces of individual and collective histories.
Does walking in nature restore directed attention?
2015-09-01
Full Text Available Aims: Mental fatigue is commonly understood and experienced as mental exhaustion, irritability and foggy thinking. Research indicates mental fatigue is indicative of depleted directed attention resources. Thus, restoration of directed attention is thought to alleviate mental fatigue. This research sought to determine if walking in nature compared to walking on a treadmill provided enhanced performance on tasks of directed attention. Method: Twenty-two participants completed a 30-min walk on a treadmill and a walk in the local Botanic Garden on separate days. Two directed attention tasks (Rapid Visual Information Processing (RVIP and Necker Cube reversal task were conducted both before and after each walk as well as a Perceived Arousal Scale and a Positive and Negative Affect Schedule. Results: Total hits and sensitivity to a target on a RVIP task improved significantly in both locations F(1, 20 = 11.892, p = .003, F(1, 20 = 12.364, p = .002 respectively. However, there was no significant difference between the nature walk and the treadmill walk. Significant order effects were found for sensitivity to targets pre/post walks, F(1, 19 = 10.309, p = .005 and F(1, 19 = 8.578, p = .009 respectively. Necker cube baseline scores indicated a significant reduction in reversals after 30 minutes of walking in both locations. Arousal was higher overall in the nature walk compared to the treadmill walk, F(1, 20 = 11.626, p = .003. Conclusions: No evidence was obtained to suggest that walking in nature leads to improved directed attention compared to walking on a treadmill. Results indicate that improvements were due to significant learning affects. The significantly higher overall score on the arousal scale in the natural environment suggests that participants were more alert in this environment.
Sequential cloning of chromosomes
Lacks, S.A.
1991-12-31
A method for sequential cloning of chromosomal DNA and chromosomal DNA cloned by this method are disclosed. The method includes the selection of a target organism having a segment of chromosomal DNA to be sequentially cloned. A first DNA segment, having a first restriction enzyme site on either side. homologous to the chromosomal DNA to be sequentially cloned is isolated. A first vector product is formed by ligating the homologous segment into a suitably designed vector. The first vector product is circularly integrated into the target organism`s chromosomal DNA. The resulting integrated chromosomal DNA segment includes the homologous DNA segment at either end of the integrated vector segment. The integrated chromosomal DNA is cleaved with a second restriction enzyme and ligated to form a vector-containing plasmid, which is replicated in a host organism. The replicated plasmid is then cleaved with the first restriction enzyme. Next, a DNA segment containing the vector and a segment of DNA homologous to a distal portion of the previously isolated DNA segment is isolated. This segment is then ligated to form a plasmid which is replicated within a suitable host. This plasmid is then circularly integrated into the target chromosomal DNA. The chromosomal DNA containing the circularly integrated vector is treated with a third, retrorestriction enzyme. The cleaved DNA is ligated to give a plasmid that is used to transform a host permissive for replication of its vector. The sequential cloning process continues by repeated cycles of circular integration and excision. The excision is carried out alternately with the second and third enzymes.
A new chromosome was born: comparative chromosome painting in Boechera.
Koch, Marcus A
2015-09-01
Comparative chromosome painting is a powerful tool to study the evolution of chromosomes and genomes. Analyzing karyotype evolution in cruciferous plants highlights the origin of aberrant chromosomes in apomictic Boechera and further establishes the cruciferous plants as important model system for our understanding of plant chromosome and genome evolution. PMID:26228436
A bidirectional YAC walk from the Norrie disease (NDP) locus
Black, G.C.; Zheng-Yi Chen; Craig, I.W. [Institute of Molecular Medicine, Oxford (United Kingdom)] [and others
1995-02-10
The region of Xp between DXS7 and the centromere contains the gene for Norrie disease in addition to the genes for several other ophthalmic disorders. A 650-kb YAC containing the loci MAOA, MAOB, and NDP has been used as the starting point for a bidirectional chromosomal walk. A contig of 16 YACs covering between 2 and 3 Mb has been developed in which the following markers/genes are located (in physical order): Xpter - DXS1201 (256ze5) - DXS6668 - DXS228 - DXS77 - DXS7 - MAOA - MAOB - FR12 (pseudogene) - NDP - DXS6670 - RRM2P3 - DXS6671 - DXS742 - Xcen. Seven new STSs are described both for end clones and for internal Alu PCR products from the contig. The contig contains the breakpoint of the t75-2ma-1b (t75) translocation, close to the 5{prime} end of the MAOB gene. 31 refs., 3 figs., 3 tabs.
Chimpanzee chromosome 13 is homologous to human chromosome 2p
Sun, N. C.; Sun, C. R.Y.; Ho, T.
1977-01-01
Similarities between human and chimpanzee chromosomes are shown by chromosome banding techniques and somatic cell hybridization techniques. Cell hybrids were obtained from the chimpanzee lymphocyte LE-7, and the Chinese hamster mutant cell, Gal-2. Experiments showed that the ACPL, MDHs, and Gal-Act genes could be assigned to chimpanzee chromosome 13, and since these genes have been assigned to human chromosme 2p, it is suggested that chimpanzee chromosome 13 is homologous to human chromosome 2p. (HLW)
Chromosome condensation and segmentation
Some aspects of chromosome condensation in mammalians -humans especially- were studied by means of cytogenetic techniques of chromosome banding. Two further approaches were adopted: a study of normal condensation as early as prophase, and an analysis of chromosome segmentation induced by physical (temperature and γ-rays) or chemical agents (base analogues, antibiotics, ...) in order to show out the factors liable to affect condensation. Here 'segmentation' means an abnormal chromosome condensation appearing systematically and being reproducible. The study of normal condensation was made possible by the development of a technique based on cell synchronization by thymidine and giving prophasic and prometaphasic cells. Besides, the possibility of inducing R-banding segmentations on these cells by BrdU (5-bromodeoxyuridine) allowed a much finer analysis of karyotypes. Another technique was developed using 5-ACR (5-azacytidine), it allowed to induce a segmentation similar to the one obtained using BrdU and identify heterochromatic areas rich in G-C bases pairs
Chromosomal abnormalities and autism
Farida El-Baz
2016-01-01
Conclusion: Chromosomal abnormalities were not detected in the studied autistic children, and so the relation between the genetics and autism still needs further work up with different study methods and techniques.
Factors Influencing Whether Children Walk to School
Su, Jason G.; Jerrett, Michael; McCONNELL, ROB; Berhane, Kiros; Dunton, Genevieve; Shankardass, Ketan; reynolds, Kim; Chang, Roger; Wolch, Jennifer
2013-01-01
Few studies have evaluated multiple levels of influence simultaneously on whether children walk to school. A large cohort of 4,338 subjects from ten communities was used to identify the determinants of walking through (1) a one-level logistic regression model for individual-level variables and (2) a two-level mixed regression model for individual and school-level variables. Walking rates were positively associated with home-to-school proximity, greater age, and living in neighborhoods charact...
Fluctuations of Quantum Random Walks on Circles
Inui, Norio; Konishi, Yoshinao; Konno, Norio; Soshi, Takahiro
2003-01-01
Temporal fluctuations in the Hadamard walk on circles are studied. A temporal standard deviation of probability that a quantum random walker is positive at a given site is introduced to manifest striking differences between quantum and classical random walks. An analytical expression of the temporal standard deviation on a circle with odd sites is shown and its asymptotic behavior is considered for large system size. In contrast with classical random walks, the temporal fluctuation of quantum...
Positive messaging promotes walking in older adults
Notthoff, Nanna; Carstensen, Laura L.
2014-01-01
Walking is among the most cost-effective and accessible means of exercise. Mounting evidence suggests that walking may help to maintain physical and cognitive independence in old age by preventing a variety of health problems. However, older Americans fall far short of meeting the daily recommendations for walking. In two studies, we examined whether considering older adults’ preferential attention to positive information may effectively enhance interventions aimed at promot...
Numerical studies of planar closed random walks
Desbois, Jean; Ouvry, Stephane
2008-01-01
Lattice numerical simulations for planar closed random walks and their winding sectors are presented. The frontiers of the random walks and of their winding sectors have a Hausdorff dimension $d_H=4/3$. However, when properly defined by taking into account the inner 0-winding sectors, the frontiers of the random walks have a Hausdorff dimension $d_H\\approx 1.77$.
Chromosome numbers in Bromeliaceae
2000-01-01
The present study reports chromosome numbers of 17 species of Bromeliaceae, belonging to the genera Encholirium, Bromelia, Orthophytum, Hohenbergia, Billbergia, Neoglaziovia, Aechmea, Cryptanthus and Ananas. Most species present 2n = 50, however, Bromelia laciniosa, Orthophytum burle-marxii and O. maracasense are polyploids with 2n = 150, 2n = 100 and 2n = 150, respectively, while for Cryptanthus bahianus, 2n = 34 + 1-4B. B chromosomes were observed in Bromelia plumieri and Hohenbergia aff. u...
Sensitivity Study of Stochastic Walking Load Models
Pedersen, Lars; Frier, Christian
2010-01-01
serviceability limit state is assessed using a walking load model in which the walking parameters are modelled deterministically. However, the walking parameters are stochastic (for instance the weight of the pedestrian is not likely to be the same for every footbridge crossing), and a natural way forward is to...... employ a stochastic load model accounting for mean values and standard deviations for the walking load parameters, and to use this as a basis for estimation of structural response. This, however, requires decisions to be made in terms of statistical istributions and their parameters, and the paper...
Walking in Place Through Virtual Worlds
Nilsson, Niels Chr.; Serafin, Stefania; Nordahl, Rolf
2016-01-01
Immersive virtual reality (IVR) is seemingly on the verge of entering the homes of consumers. Enabling users to walk through virtual worlds in a limited physical space presents a challenge. With an outset in a taxonomy of virtual travel techniques, we argue that Walking-in-Place (WIP) techniques...... constitute a promising approach to virtual walking in relation to consumer IVR. Subsequently we review existing approaches to WIP locomotion and highlight the need for a more explicit focus on the perceived naturalness of WIP techniques; i.e., the degree to which WIP locomotion feels like real walking...
Quantum Walks for Computer Scientists
Venegas-Andraca, Salvador
2008-01-01
Quantum computation, one of the latest joint ventures between physics and the theory of computation, is a scientific field whose main goals include the development of hardware and algorithms based on the quantum mechanical properties of those physical systems used to implement such algorithms. Solving difficult tasks (for example, the Satisfiability Problem and other NP-complete problems) requires the development of sophisticated algorithms, many of which employ stochastic processes as their mathematical basis. Discrete random walks are a popular choice among those stochastic processes. Inspir
Quantum Walks with Encrypted Data
Rohde, Peter P.; Fitzsimons, Joseph F.; Gilchrist, Alexei
2012-10-01
In the setting of networked computation, data security can be a significant concern. Here we consider the problem of allowing a server to remotely manipulate client supplied data, in such a way that both the information obtained by the client about the server’s operation and the information obtained by the server about the client’s data are significantly limited. We present a protocol for achieving such functionality in two closely related models of restricted quantum computation—the boson sampling and quantum walk models. Because of the limited technological requirements of the boson scattering model, small scale implementations of this technique are feasible with present-day technology.
Random Walks Estimate Land Value
Blanchard, Ph
2010-01-01
Expected urban population doubling calls for a compelling theory of the city. Random walks and diffusions defined on spatial city graphs spot hidden areas of geographical isolation in the urban landscape going downhill. First--passage time to a place correlates with assessed value of land in that. The method accounting the average number of random turns at junctions on the way to reach any particular place in the city from various starting points could be used to identify isolated neighborhoods in big cities with a complex web of roads, walkways and public transport systems.
Topology of Minimal Walking Technicolor
We perform a lattice study of the topological susceptibility and instanton size distribution of the SU(2) gauge theory with two adjoint Dirac fermions (also known as Minimal Walking Technicolor), which is known to be in the conformal window. In the theory deformed with a small mass term, by drawing a comparison with the pure gauge theory, we find that topological observables are decoupled from the fermion dynamics. This provides further evidence for the infrared conformality of the theory. A study of the instanton size distribution shows that this quantity can be used to detect the onset of finite size effects. (orig.)
Orbiting pairs of walking droplets
Siefert, Emmanuel; Bush, John W. M.; Oza, Anand
2015-11-01
Droplets may self-propel on the surface of a vibrating fluid bath, pushed forward by their own Faraday pilot-wave field. We present the results of a combined experimental and theoretical investigation of the interaction of pairs of such droplets. Particular attention is given to characterizing the system's dependence on the vibrational forcing of the bath and the impact parameter of the walking droplets. Observed criteria for the capture and stability of orbital pairs are rationalized by accompanying theoretical developments. Thanks to the NSF.
Micromechanics of human mitotic chromosomes
Eukaryote cells dramatically reorganize their long chromosomal DNAs to facilitate their physical segregation during mitosis. The internal organization of folded mitotic chromosomes remains a basic mystery of cell biology; its understanding would likely shed light on how chromosomes are separated from one another as well as into chromosome structure between cell divisions. We report biophysical experiments on single mitotic chromosomes from human cells, where we combine micromanipulation, nano-Newton-scale force measurement and biochemical treatments to study chromosome connectivity and topology. Results are in accord with previous experiments on amphibian chromosomes and support the 'chromatin network' model of mitotic chromosome structure. Prospects for studies of chromosome-organizing proteins using siRNA expression knockdowns, as well as for differential studies of chromosomes with and without mutations associated with genetic diseases, are also discussed
Vibrio chromosomes share common history
Gevers Dirk
2010-05-01
Full Text Available Abstract Background While most gamma proteobacteria have a single circular chromosome, Vibrionales have two circular chromosomes. Horizontal gene transfer is common among Vibrios, and in light of this genetic mobility, it is an open question to what extent the two chromosomes themselves share a common history since their formation. Results Single copy genes from each chromosome (142 genes from chromosome I and 42 genes from chromosome II were identified from 19 sequenced Vibrionales genomes and their phylogenetic comparison suggests consistent phylogenies for each chromosome. Additionally, study of the gene organization and phylogeny of the respective origins of replication confirmed the shared history. Conclusions Thus, while elements within the chromosomes may have experienced significant genetic mobility, the backbones share a common history. This allows conclusions based on multilocus sequence analysis (MLSA for one chromosome to be applied equally to both chromosomes.
Row Lazzarini, Brandi S; Kataras, Theodore J
2016-05-01
Treadmills are appealing for gait studies, but some gait mechanics are disrupted during treadmill walking. The purpose of this study was to examine the effects of speed and treadmill walking on walking smoothness and rhythmicity of 40 men and women between the ages of 70-96 years. Gait smoothness was examined during overground (OG) and treadmill (TM) walking by calculating the harmonic ratio from linear accelerations measured at the level of the lumbar spine. Rhythmicity was quantified as the stride time standard deviation. TM walking was performed at two speeds: a speed matching the natural OG walk speed (TM-OG), and a preferred TM speed (PTM). A dual-task OG condition (OG-DT) was evaluated to determine if TM walking posed a similar cognitive challenge. Statistical analysis included a one-way Analysis of Variance with Bonferroni corrected post hoc comparisons and the Wilcoxon signed rank test for non-normally distributed variables. Average PTM speed was slower than OG. Compared to OG, those who could reach the TM-OG speed (74.3% of sample) exhibited improved ML smoothness and rhythmicity, and the slower PTM caused worsened vertical and AP smoothness, but did not affect rhythmicity. PTM disrupted smoothness and rhythmicity differently than the OG-DT condition, likely due to reduced speed. The use of treadmills for gait smoothness and rhythmicity studies in older adults is problematic; some participants will not achieve OG speed during TM walking, walking at the TM-OG speed artificially improves rhythmicity and ML smoothness, and walking at the slower PTM speed worsens vertical and AP gait smoothness. PMID:27131175
Cellular telephone use during free-living walking significantly reduces average walking speed
Jacob E. Barkley; Lepp, Andrew
2016-01-01
Background Cellular telephone (cell phone) use decreases walking speed in controlled laboratory experiments and there is an inverse relationship between free-living walking speed and heart failure risk. The purpose of this study was to examine the impact of cell phone use on walking speed in a free-living environment. Methods Subjects (n = 1142) were randomly observed walking on a 50 m University campus walkway. The time it took each subject to walk 50 m was recorded and subjects were coded i...
Walking on high heels changes muscle activity and the dynamics of human walking significantly
Simonsen, Erik Bruun; Svendsen, Morten B; Nørreslet, Andreas;
2012-01-01
The aim of the study was to investigate the distribution of net joint moments in the lower extremities during walking on high-heeled shoes compared with barefooted walking at identical speed. Fourteen female subjects walked at 4 km/h across three force platforms while they were filmed by five...... joint abductor moment. Several EMG parameters increased significantly when walking on high-heels. The results indicate a large increase in bone-on-bone forces in the knee joint directly caused by the increased knee joint extensor moment during high-heeled walking, which may explain the observed higher...
Transition matrix from a random walk
Schulman, Lawrence S
2016-01-01
Given a random walk a method is presented to produce a matrix of transition probabilities that is consistent with that random walk. The method is tested by using a transition matrix to produce a path and then using that path to create the estimate. The two matrices are then compared.
Rhythmic walking interactions with auditory feedback
Jylhä, Antti; Serafin, Stefania; Erkut, Cumhur
2012-01-01
Walking is a natural rhythmic activity that has become of interest as a means of interacting with software systems such as computer games. Therefore, designing multimodal walking interactions calls for further examination. This exploratory study presents a system capable of different kinds of...
Non-Markovian decoherent quantum walks
Xue Peng; Zhang Yong-Sheng
2013-01-01
Quantum walks act in obviously different ways from their classical counterparts,but decoherence will lessen and close this gap between them.To understand this process,it is necessary to investigate the evolution of quantum walks under different decoherence situations.In this article,we study a non-Markovian decoherent quantum walk on a line.In a short time regime,the behavior of the walk deviates from both ideal quantum walks and classical random walks.The position variance as a measure of the quantum walk collapses and revives for a short time,and tends to have a linear relation with time.That is,the walker's behavior shows a diffusive spread over a long time limit,which is caused by non-Markovian dephasing affecting the quantum correlations between the quantum walker and his coin.We also study both quantum discord and measurement-induced disturbance as measures of the quantum correlations,and observe both collapse and revival in the short time regime,and the tendency to be zero in the long time limit.Therefore,quantum walks with non-Markovian decoherence tend to have diffusive spreading behavior over long time limits,while in the short time regime they oscillate between ballistic and diffusive spreading behavior,and the quantum correlation collapses and revives due to the memory effect.
Walking in circles: a modelling approach.
Maus, Horst-Moritz; Seyfarth, Andre
2014-10-01
Blindfolded or disoriented people have the tendency to walk in circles rather than on a straight line even if they wanted to. Here, we use a minimalistic walking model to examine this phenomenon. The bipedal spring-loaded inverted pendulum exhibits asymptotically stable gaits with centre of mass (CoM) dynamics and ground reaction forces similar to human walking in the sagittal plane. We extend this model into three dimensions, and show that stable walking patterns persist if the leg is aligned with respect to the body (here: CoM velocity) instead of a world reference frame. Further, we demonstrate that asymmetric leg configurations, which are common in humans, will typically lead to walking in circles. The diameter of these circles depends strongly on parameter configuration, but is in line with empirical data from human walkers. Simulation results suggest that walking radius and especially direction of rotation are highly dependent on leg configuration and walking velocity, which explains inconsistent veering behaviour in repeated trials in human data. Finally, we discuss the relation between findings in the model and implications for human walking. PMID:25056215
Exact enumeration of self-avoiding walks
Schram, Raoul D.; Barkema, Gerard T.; Bisseling, Rob H.
2011-01-01
A prototypical problem on which techniques for exact enumeration are tested and compared is the enumeration of self-avoiding walks. Here, we show an advance in the methodology of enumeration, making the process thousands or millions of times faster. This allowed us to enumerate self-avoiding walks on the simple cubic lattice up to a length of 36 steps.
Walking on high heels changes muscle activity and the dynamics of human walking significantly
Simonsen, Erik B; Svendsen, Morten Bo Søndergaard; Nørreslet, Andreas;
2012-01-01
The aim of the study was to investigate the distribution of net joint moments in the lower extremities during walking on high-heeled shoes compared with barefooted walking at identical speed. Fourteen female subjects walked at 4 km/h across three force platforms while they were filmed by five...... digital video cameras operating at 50 frames/second. Both barefooted walking and walking on high-heeled shoes (heel height: 9 cm) were recorded. Net joint moments were calculated by 3D inverse dynamics. EMG was recorded from eight leg muscles. The knee extensor moment peak in the first half of the stance...... joint abductor moment. Several EMG parameters increased significantly when walking on high-heels. The results indicate a large increase in bone-on-bone forces in the knee joint directly caused by the increased knee joint extensor moment during high-heeled walking, which may explain the observed higher...
Walk modularity and community structure in networks
Mehrle, David; Harkin, Anthony
2014-01-01
Modularity maximization has been one of the most widely used approaches in the last decade for discovering community structure in networks of practical interest in biology, computing, social science, statistical mechanics, and more. Modularity is a quality function that measures the difference between the number of edges found within clusters minus the number of edges one would statistically expect to find based on random chance. We present a natural generalization of modularity based on the difference between the actual and expected number of walks within clusters, which we call walk-modularity. Walk-modularity can be expressed in matrix form, and community detection can be performed by finding leading eigenvectors of the walk-modularity matrix. We demonstrate community detection on both synthetic and real-world networks and find that walk-modularity maximization returns significantly improved results compared to traditional modularity maximization.
Efficient quantum walk on a quantum processor.
Qiang, Xiaogang; Loke, Thomas; Montanaro, Ashley; Aungskunsiri, Kanin; Zhou, Xiaoqi; O'Brien, Jeremy L; Wang, Jingbo B; Matthews, Jonathan C F
2016-01-01
The random walk formalism is used across a wide range of applications, from modelling share prices to predicting population genetics. Likewise, quantum walks have shown much potential as a framework for developing new quantum algorithms. Here we present explicit efficient quantum circuits for implementing continuous-time quantum walks on the circulant class of graphs. These circuits allow us to sample from the output probability distributions of quantum walks on circulant graphs efficiently. We also show that solving the same sampling problem for arbitrary circulant quantum circuits is intractable for a classical computer, assuming conjectures from computational complexity theory. This is a new link between continuous-time quantum walks and computational complexity theory and it indicates a family of tasks that could ultimately demonstrate quantum supremacy over classical computers. As a proof of principle, we experimentally implement the proposed quantum circuit on an example circulant graph using a two-qubit photonics quantum processor. PMID:27146471
One dimensional quantum walk with unitary noise
Shapira, D; Bracken, A J; Hackett, M; Shapira, Daniel; Biham, Ofer; Hackett, Michelle
2003-01-01
The effect of unitary noise on the discrete one-dimensional quantum walk is studied using computer simulations. For the noiseless quantum walk, starting at the origin (n=0) at time t=0, the position distribution Pt(n) at time t is very different from the Gaussian distribution obtained for the classical random walk. Furthermore, its standard deviation, sigma(t) scales as sigma(t) ~ t, unlike the classical random walk for which sigma(t) ~ sqrt{t}. It is shown that when the quantum walk is exposed to unitary noise, it exhibits a crossover from quantum behavior for short times to classical-like behavior for long times. The crossover time is found to be T ~ alpha^(-2) where alpha is the standard deviation of the noise.
Locomotor sequence learning in visually guided walking
Choi, Julia T; Jensen, Peter; Nielsen, Jens Bo
2016-01-01
Voluntary limb modifications must be integrated with basic walking patterns during visually guided walking. Here we tested whether voluntary gait modifications can become more automatic with practice. We challenged walking control by presenting visual stepping targets that instructed subjects to...... modify step length from one trial to the next. Our sequence learning paradigm is derived from the serial reaction-time (SRT) task that has been used in upper limb studies. Both random and ordered sequences of step lengths were used to measure sequence-specific and sequence non-specific learning during...... walking. In addition, we determined how age (i.e., healthy young adults vs. children) and biomechanical factors (i.e., walking speed) affected the rate and magnitude of locomotor sequence learning. The results showed that healthy young adults (age 24 ± 5 years, N = 20) could learn a specific sequence of...
Efficient quantum walk on a quantum processor
Qiang, Xiaogang; Loke, Thomas; Montanaro, Ashley; Aungskunsiri, Kanin; Zhou, Xiaoqi; O'Brien, Jeremy L.; Wang, Jingbo B.; Matthews, Jonathan C. F.
2016-05-01
The random walk formalism is used across a wide range of applications, from modelling share prices to predicting population genetics. Likewise, quantum walks have shown much potential as a framework for developing new quantum algorithms. Here we present explicit efficient quantum circuits for implementing continuous-time quantum walks on the circulant class of graphs. These circuits allow us to sample from the output probability distributions of quantum walks on circulant graphs efficiently. We also show that solving the same sampling problem for arbitrary circulant quantum circuits is intractable for a classical computer, assuming conjectures from computational complexity theory. This is a new link between continuous-time quantum walks and computational complexity theory and it indicates a family of tasks that could ultimately demonstrate quantum supremacy over classical computers. As a proof of principle, we experimentally implement the proposed quantum circuit on an example circulant graph using a two-qubit photonics quantum processor.
Chromosome numbers in Bromeliaceae
Cotias-de-Oliveira Ana Lúcia Pires
2000-01-01
Full Text Available The present study reports chromosome numbers of 17 species of Bromeliaceae, belonging to the genera Encholirium, Bromelia, Orthophytum, Hohenbergia, Billbergia, Neoglaziovia, Aechmea, Cryptanthus and Ananas. Most species present 2n = 50, however, Bromelia laciniosa, Orthophytum burle-marxii and O. maracasense are polyploids with 2n = 150, 2n = 100 and 2n = 150, respectively, while for Cryptanthus bahianus, 2n = 34 + 1-4B. B chromosomes were observed in Bromelia plumieri and Hohenbergia aff. utriculosa. The chromosome number of all species was determined for the first time, except for Billbergia chlorosticta and Cryptanthus bahianus. Our data supports the hypothesis of a basic number of x = 25 for the Bromeliaceae family and decreasing aneuploidy in the genus Cryptanthus.
Those amazing dinoflagellate chromosomes
PETER J RIZZO
2003-01-01
Dinoflagellates are a very large and diverse group of eukaryotic algae that play a major role in aquatic food webs of both fresh water and marine habitats. Moreover, the toxic members of this group pose a health threat in the form of red tides. Finally, dinoflagellates are of great evolutionary importance,because of their taxonomic position, and their unusual chromosome structure and composition. While the cytoplasm of dinoflagellates is typically eukaryotic, the nucleus is unique when compared to the nucleus of other eukaryotes. More specifically, while the chromosomes of all other eukaryotes contain histones,dinoflagellate chromosomes lack histones completely. There are no known exceptions to this observation: all dinoflagellates lack histones, and all other eukaryotes contain histones. Nevertheless, dinoflagellates remain a relatively unstudied group of eukaryotes.
Chromosome evolution with naked eye: Palindromic context of the life origin
Larionov, Sergei; Loskutov, Alexander; Ryadchenko, Eugeny
2008-03-01
Based on the representation of the DNA sequence as a two-dimensional (2D) plane walk, we consider the problem of identification and comparison of functional and structural organizations of chromosomes of different organisms. According to the characteristic design of 2D walks we identify telomere sites, palindromes of various sizes and complexity, areas of ribosomal RNA, transposons, as well as diverse satellite sequences. As an interesting result of the application of the 2D walk method, a new duplicated gigantic palindrome in the X human chromosome is detected. A schematic mechanism leading to the formation of such a duplicated palindrome is proposed. Analysis of a large number of the different genomes shows that some chromosomes (or their fragments) of various species appear as imperfect gigantic palindromes, which are disintegrated by many inversions and the mutation drift on different scales. A spread occurrence of these types of sequences in the numerous chromosomes allows us to develop a new insight of some accepted points of the genome evolution in the prebiotic phase.
Quantum walking in curved spacetime
Arrighi, Pablo; Facchini, Stefano; Forets, Marcelo
2016-08-01
A discrete-time quantum walk (QW) is essentially a unitary operator driving the evolution of a single particle on the lattice. Some QWs admit a continuum limit, leading to familiar PDEs (e.g., the Dirac equation). In this paper, we study the continuum limit of a wide class of QWs and show that it leads to an entire class of PDEs, encompassing the Hamiltonian form of the massive Dirac equation in (1+1) curved spacetime. Therefore, a certain QW, which we make explicit, provides us with a unitary discrete toy model of a test particle in curved spacetime, in spite of the fixed background lattice. Mathematically, we have introduced two novel ingredients for taking the continuum limit of a QW, but which apply to any quantum cellular automata: encoding and grouping.
Deterministic Walks in Random Media
Deterministic walks over a random set of N points in one and two dimensions (d=1,2 ) are considered. Points ('cities') are randomly scattered in Rd following a uniform distribution. A walker ('tourist'), at each time step, goes to the nearest neighbor city that has not been visited in the past τ steps. Each initial city leads to a different trajectory composed of a transient part and a final p -cycle attractor. Transient times (for d=1,2 ) follow an exponential law with a τ -dependent decay time but the density of p cycles can be approximately described by D(p)∝p-α (τ) . For τmuchgt1 and τ/Nmuchlt1 , the exponent is independent of τ . Some analytical results are given for the d=1 case
Yerle Martine
2003-11-01
Full Text Available Abstract A pericentric inversion of chromosome 4 in a boar, as well as a case of (2q-;5p+ translocation mosaicism in a bull were analysed by chromosome painting using probes generated by conventional microdissection. For the porcine inversion, probes specific for p arms and q arms were produced and hybridised simultaneously on metaphases of a heterozygote carrier. In the case of the bovine translocation, two whole chromosome probes (chromosome 5, and derived chromosome 5 were elaborated and hybridised independently on chromosomal preparations of the bull who was a carrier of the mosaic translocation. The impossibility of differentiating chromosomes 2 and der(2 from other chromosomes of the metaphases did not allow the production of painting probes for these chromosomes. For all experiments, the quality of painting was comparable to that usually observed with probes obtained from flow-sorted chromosomes. The results obtained allowed confirmation of the interpretations proposed with G-banding karyotype analyses. In the bovine case, however, the reciprocity of the translocation could not be proven. The results presented in this paper show the usefulness of the microdissection technique for characterising chromosomal rearrangements in species for which commercial probes are not available. They also confirmed that the main limiting factor of the technique is the quality of the chromosomal preparations, which does not allow the identification of target chromosomes or chromosome fragments in all cases.
Blindman-Walking Optimization Method
Chunming Li
2010-12-01
Full Text Available Optimization methods are all implemented with the hypothesis of unknowing the mathematic express of objective objection. Using the human analogy innovative method, the one-dimension blind-walking optimal method is proposed in this paper. The theory and the algorithm of this method includes halving, doubling, reversing probing step and verifying the applicability condition. Double-step is available to make current point moving to the extremum point. Half-step is available to accelerate convergence. In order to improve the optimization, the applicability condition decides whether update current point or not. The operation process, algorithmic flow chart and characteristic analysis of the method were given. Two optimization problems with unimodal or multimodal objective function were solved by the proposed method respectively. The simulation result shows that the proposed method is better than the ordinary method. The proposed method has the merit of rapid convergence, little calculation capacity, wide applicable range, etc. Taking the method as innovative kernel, the random research method, feasible direction method and complex shape method were improved. Taking the innovative content of this paper as innovative kernel, a monograph was published. The other innovations of the monograph are listed, such as applied algorithm of Karush-Kuhn-Tucker (KKT qualifications on judging the restriction extremum point, the design step of computing software, the complementarity and derivation of Powell criterion, the method of keeping the complex shape not to deduce dimension and the analysis of gradual optimization characteristic, the reinforced wall of inner point punish function method, the analysis of problem with constrained monstrosity extremum point, the improvement of Newton method and the validation of optimization idea of blind walking repeatedly, the explanation of later-day optimization method, the conformity of seeking algorithm needing the
The Q locus played a major role in the domestication of wheat because it confers the free-threshing character and influences many other agronomically important traits. We constructed a physical contig spanning the Q locus using a Triticum monococcum BAC library. Four chromosome walking steps were ...
Kenneth Joh
2015-07-01
Full Text Available Promoting walking travel is considered important for reducing automobile use and improving public health. Recent U.S. transportation policy has incentivized investments in alternative, more sustainable transportation modes such as walking, bicycling and transit in auto-oriented cities such as Los Angeles. Although many past studies have analyzed changes in walking travel across the U.S., there is little clarity on the drivers of change. We address this gap by conducting a longitudinal analysis of walking travel in the greater Los Angeles area from 2001 to 2009. We use travel diary and household data from regional and national surveys to analyze changes in walking trip shares and rates across our study area. Results show that walking has significantly increased across most of Los Angeles, and that increases in walking trips generally correspond with increases in population, employment, and transit service densities. Estimates from fixed-effects regression analysis generally suggest a positive association between population density and walking, and that higher increases in transit stop density are correlated with increased walking trips to and from transit stops. These findings illustrate how regional planning efforts to pursue a coordinated land use-transit planning strategy can help promote walking in auto-oriented or vehicle adopting cities.
Brandt, C A; Hertz, Jens Michael; Petersen, M B; Vogel, F; Noer, H; Mikkelsen, M
1992-01-01
A stillborn male child with anencephaly and multiple malformations was found to have the karyotype 46,XY,r(13) (p11q21.1). The breakpoint at 13q21.1, determined by high resolution banding, is the most proximal breakpoint ever reported in patients with ring chromosome 13. In situ hybridisation with...
Offner, Susan
2010-01-01
The Y chromosome is of great interest to students and can be used to teach about many important biological concepts in addition to sex determination. This paper discusses mutation, recombination, mammalian sex determination, sex determination in general, and the evolution of sex determination in mammals. It includes a student activity that…
Chromosomes, cancer and radiosensitivity
Samouhos, E.
1983-08-01
Some specific chromosomal abnormalities are associated with certain cancers. The earliest description of such a specific association is the one of the Philadelphia chromosome and myelogenous leukemia (1960). Other congenital karyotype abnormalities are associated with specific cancers. Examples of these are Down's syndrome with leukemia and Klinefelter's syndrome with male breast cancer. Genetic diseases of increased chromosome breakage, or of defective chromosome repair, are associated with greatly increased cancer incidence. Three such diseases have been recognized: 1) Fanconi's anemia, associated with leukemias and lymphomas, 2) Bloom's syndrome, associated with acute leukemias and lymphosarcoma, and 3) ataxia telangiectasia, associated with Hodgkin's disease, leukemia, and lymphosarcomas. Ten percent of individuals with ataxia telangiectasia will develop one of these neoplasms. Individuals with certain of these syndromes display an unusually high radiosensitivity. Radiation therapy for cancers has been fatal in patients who received as low as 3000 rad. This remarkable radiosensitivity has been quantitated in cell cultures from such cases. Evidence suggests that the apparent sensitivity may reflect subnormal ability to repair radiation damage. The rapid proliferation of information in this field stems from the interdigitation of many disciplines and specialties, including cytogenetics, cell biology, molecular biology, epidemiology, radiobiology, and several others. This paper is intended for clinicians; it presents a structured analytic scheme for correlating and classifying this multidisciplinary information as it becomes available.
Chromosomes, cancer and radiosensitivity
Some specific chromosomal abnormalities are associated with certain cancers. The earliest description of such a specific association is the one of the Philadelphia chromosome and myelogenous leukemia (1960). Other congenital karyotype abnormalities are associated with specific cancers. Examples of these are Down's syndrome with leukemia and Klinefelter's syndrome with male breast cancer. Genetic diseases of increased chromosome breakage, or of defective chromosome repair, are associated with greatly increased cancer incidence. Three such diseases have been recognized: 1) Fanconi's anemia, associated with leukemias and lymphomas, 2) Bloom's syndrome, associated with acute leukemias and lymphosarcoma, and 3) ataxia telangiectasia, associated with Hodgkin's disease, leukemia, and lymphosarcomas. Ten percent of individuals with ataxia telangiectasia will develop one of these neoplasms. Individuals with certain of these syndromes display an unusually high radiosensitivity. Radiation therapy for cancers has been fatal in patients who received as low as 3000 rad. This remarkable radiosensitivity has been quantitated in cell cultures from such cases. Evidence suggests that the apparent sensitivity may reflect subnormal ability to repair radiation damage. The rapid proliferation of information in this field stems from the interdigitation of many disciplines and specialties, including cytogenetics, cell biology, molecular biology, epidemiology, radiobiology, and several others. This paper is intended for clinicians; it presents a structured analytic scheme for correlating and classifying this multidisciplinary information as it becomes available
Chromosome Morphology in Kniphofia.
J. M. J de Wet
1960-12-01
Full Text Available A number of species and varieties of the genus Kniphofia (Liliaceae were studied cytologically. The somatic chromosome number is 2n = 12 in all the species. This is also true in Notosceptrum natalense Baker.
Telomere dysfunction and chromosome instability
Murnane, John P., E-mail: jmurnane@radonc.ucsf.edu [Department of Radiation Oncology, University of California San Francisco, 2340 Sutter Street, San Francisco, CA 94143-1331 (United States)
2012-02-01
The ends of chromosomes are composed of a short repeat sequence and associated proteins that together form a cap, called a telomere, that keeps the ends from appearing as double-strand breaks (DSBs) and prevents chromosome fusion. The loss of telomeric repeat sequences or deficiencies in telomeric proteins can result in chromosome fusion and lead to chromosome instability. The similarity between chromosome rearrangements resulting from telomere loss and those found in cancer cells implicates telomere loss as an important mechanism for the chromosome instability contributing to human cancer. Telomere loss in cancer cells can occur through gradual shortening due to insufficient telomerase, the protein that maintains telomeres. However, cancer cells often have a high rate of spontaneous telomere loss despite the expression of telomerase, which has been proposed to result from a combination of oncogene-mediated replication stress and a deficiency in DSB repair in telomeric regions. Chromosome fusion in mammalian cells primarily involves nonhomologous end joining (NHEJ), which is the major form of DSB repair. Chromosome fusion initiates chromosome instability involving breakage-fusion-bridge (B/F/B) cycles, in which dicentric chromosomes form bridges and break as the cell attempts to divide, repeating the process in subsequent cell cycles. Fusion between sister chromatids results in large inverted repeats on the end of the chromosome, which amplify further following additional B/F/B cycles. B/F/B cycles continue until the chromosome acquires a new telomere, most often by translocation of the end of another chromosome. The instability is not confined to a chromosome that loses its telomere, because the instability is transferred to the chromosome donating a translocation. Moreover, the amplified regions are unstable and form extrachromosomal DNA that can reintegrate at new locations. Knowledge concerning the factors promoting telomere loss and its consequences is
Organization of the bacterial chromosome.
Krawiec, S.; Riley, M
1990-01-01
Recent progress in studies on the bacterial chromosome is summarized. Although the greatest amount of information comes from studies on Escherichia coli, reports on studies of many other bacteria are also included. A compilation of the sizes of chromosomal DNAs as determined by pulsed-field electrophoresis is given, as well as a discussion of factors that affect gene dosage, including redundancy of chromosomes on the one hand and inactivation of chromosomes on the other hand. The distinction ...
Nordic walking and chronic low back pain
Morsø, Lars; Hartvigsen, Jan; Puggaard, Lis;
2006-01-01
Low Back Pain is a major public health problem all over the western world. Active approaches including exercise in the treatment of low back pain results in better outcomes for patients, but it is not known exactly which types of back exercises are most beneficial or whether general physical...... activity provide similar benefits. Nordic Walking is a popular and fast growing type of exercise in Northern Europe. Initial studies have demonstrated that persons performing Nordic Walking are able to exercise longer and harder compared to normal walking thereby increasing their cardiovascular metabolism...
Elements of random walk and diffusion processes
Ibe, Oliver C
2013-01-01
Presents an important and unique introduction to random walk theory Random walk is a stochastic process that has proven to be a useful model in understanding discrete-state discrete-time processes across a wide spectrum of scientific disciplines. Elements of Random Walk and Diffusion Processes provides an interdisciplinary approach by including numerous practical examples and exercises with real-world applications in operations research, economics, engineering, and physics. Featuring an introduction to powerful and general techniques that are used in the application of physical and dynamic
Florescu, Laura; Levine, Lionel; Peres, Yuval
2014-01-01
In a \\emph{rotor walk} the exits from each vertex follow a prescribed periodic sequence. On an infinite Eulerian graph embedded periodically in $\\R^d$, we show that any simple rotor walk, regardless of rotor mechanism or initial rotor configuration, visits at least on the order of $t^{d/(d+1)}$ distinct sites in $t$ steps. We prove a shape theorem for the rotor walk on the comb graph with i.i.d.\\ uniform initial rotors, showing that the range is of order $t^{2/3}$ and the asymptotic shape of ...
Scaling of random walk betweenness in networks
Narayan, O
2016-01-01
The betweenness centrality of graphs using random walk paths instead of geodesics is studied. A scaling collapse with no adjustable parameters is obtained as the graph size $N$ is varied; the scaling curve depends on the graph model. A normalized random betweenness, that counts each walk passing through a node only once, is also defined. It is argued to be more useful and seen to have simpler scaling behavior. In particular, the probability for a random walk on a preferential attachment graph to pass through the root node is found to tend to unity as $N\\rightarrow\\infty.$
End patterns of self-avoiding walks
Consider a fixed end pattern (a short self-avoiding walk) that can occur as the first few steps of an arbitrarily long self-avoiding walk on Z/sup d/. It is a difficult open problem to show that as N → ∞, the fraction of N-step self-avoiding walks beginning with this pattern converges. It is shown that as N → ∞, this fraction is bounded away from zero, and that the ratio of the fractions for N and N + 2 converges to one. Similar results are obtained when patterns are specified at both ends, and also when the endpoints are fixed
Families of prudent self-avoiding walks
Bousquet-Mélou, Mireille
2010-01-01
A self-avoiding walk (SAW) on the square lattice is prudent if it never takes a step towards a vertex it has already visited. Prudent walks differ from most classes of SAW that have been counted so far in that they can wind around their starting point. Their enumeration was first addressed by Préa in 1997. He defined 4 classes of prudent walks, of increasing generality, and wrote a system of recurrence relations for each of them . However, these relations involve more and more parameters as t...
Quantum walk public-key cryptographic system
Vlachou, C.; Rodrigues, J.; Mateus, P.; Paunković, N.; Souto, A.
2015-12-01
Quantum Cryptography is a rapidly developing field of research that benefits from the properties of Quantum Mechanics in performing cryptographic tasks. Quantum walks are a powerful model for quantum computation and very promising for quantum information processing. In this paper, we present a quantum public-key cryptographic system based on quantum walks. In particular, in the proposed protocol the public-key is given by a quantum state generated by performing a quantum walk. We show that the protocol is secure and analyze the complexity of public key generation and encryption/decryption procedures.
How do environmental factors influence walking in groups? A walk-along study.
Kassavou, Aikaterini; French, David P; Chamberlain, Kerry
2015-10-01
Insufficient attention has been given to the influence of context on health-related behaviour change. This article reports on walk-along interviews conducted with 10 leaders of walking groups while leading their groups to investigate the influence of contextual factors on walking behaviours in groups. Data analysis used ideas from thematic analysis and grounded theory, approaching the data inductively. We identified that characteristics of place influenced the type of walking that people do in groups and the processes used by walkers to make sense of their behaviours in the places they walk. This research provides insight into how place influences walking in groups. It also suggests recommendations for co-ordinators and policymakers that could be used to facilitate behaviour change, when designing interventions targeting public health within the community. PMID:24296734
Quantum Ultra-Walks: Walks on a Line with Spatial Disorder
Boettcher, Stefan; Falkner, Stefan
We discuss the model of a heterogeneous discrete-time walk on a line with spatial disorder in the form of a set of ultrametric barriers. Simulations show that such an quantum ultra-walk spreads with a walk exponent dw that ranges from ballistic (dw = 1) to complete confinement (dw = ∞) for increasing separation 1 internal degrees of freedom. For the random walk, this amounts to a 2nd -order Markov process with a stochastic coin, better know as an (anti-)persistent walk. The exact analysis, based on the real-space renormalization group (RG), reproduces the results of the well-known model of ``ultradiffusion,'' dw = 1 -log2 ɛ for 0 < ɛ <= 1 / 2 . However, while the evaluation of the RG fixed-points proceeds virtually identical, for the corresponding quantum walk with a unitary coin it fails to reproduce the numerical results. A new way to analyze the RG is indicated. Supported by NSF-DMR 1207431.
[Chromosomal organization of the genomes of small-chromosome plants].
Muravenko, O V; Zelenin, A V
2009-11-01
An effective approach to study the chromosome organization in genomes of plants with small chromosomes and/or with low-informative C-banding patterns was developed in the course of investigation of the karyotypes of cotton plant, camomile, flax, and pea. To increase the resolving power of chromosome analysis, methods were worked out for revealing early replication patterns on chromosomes and for artificial impairment of mitotic chromosome condensation with the use of a DNA intercalator, 9-aminoacridine (9-AMA). To estimate polymorphism of the patterns of C-banding of small chromosomes on preparations obtained with the use of 9-AMA, it is necessary to choose a length interval that must not exceed three average sizes of metaphase chromosomes without the intercalator. The use of 9-AMA increases the resolution of differential C- and OR-banding and the precision of physical chromosome mapping by the FISH method. Of particular importance in studying small chromosomes is optimization of the computer-aided methods used to obtain and process chromosome images. The complex approach developed for analysis of the chromosome organization in plant genomes was used to study the karyotypes of 24 species of the genus Linum L. It permitted their chromosomes to be identified for the first time, and, in addition, B chromosomes were discovered and studied in the karyotypes of the species of the section Syllinum. By similarity of the karyotypes, the studied flax species were distributed in eight groups in agreement with the clusterization of these species according to the results of RAPD analysis performed in parallel. Systematic positions and phylogenetic relationships of the studied flax species were verified. Out results can serve as an important argument in favour of the proposal to develop a special program for sequencing the genome of cultivated flax (L. usitatissimum L.), which is a major representative of small-chromosome species. PMID:20058798
Walking and Eating Behavior of Toddlers at 12 Months Old
Koda, Naoko; Akimoto, Yuko; Hirose, Toshiya; Hinobayashi, Toshihiko; Minami, Tetsuhiro
2004-01-01
Locomotive and eating behavior of 52 toddlers was observed at 12 months old in a nursery school and investigated in relation to the acquisition of independent walking. The toddlers who acquired walking ate more by themselves using the hands than the toddlers who did not start walking. This suggested that acquisition of walking was associated with…
Quantum random walks with decoherent coins
The quantum random walk has been much studied recently, largely due to its highly nonclassical behavior. In this paper, we study one possible route to classical behavior for the discrete quantum walk on the line: the presence of decoherence in the quantum ''coin'' which drives the walk. We find exact analytical expressions for the time dependence of the first two moments of position, and show that in the long-time limit the variance grows linearly with time, unlike the unitary walk. We compare this to the results of direct numerical simulation, and see how the form of the position distribution changes from the unitary to the usual classical result as we increase the strength of the decoherence
Real time visualization of quantum walk
Miyazaki, Akihide; Hamada, Shinji; Sekino, Hideo [Department of Computer Science and Engineering, Toyohashi University of Technology, 1-1 Hibarigaoka Tenpaku-cho, Toyohashi, 441-8580 Aichi (Japan)
2014-02-20
Time evolution of quantum particles like electrons is described by time-dependent Schrödinger equation (TDSE). The TDSE is regarded as the diffusion equation of electrons with imaginary diffusion coefficients. And the TDSE is solved by quantum walk (QW) which is regarded as a quantum version of a classical random walk. The diffusion equation is solved in discretized space/time as in the case of classical random walk with additional unitary transformation of internal degree of freedom typical for quantum particles. We call the QW for solution of the TDSE a Schrödinger walk (SW). For observation of one quantum particle evolution under a given potential in atto-second scale, we attempt a successive computation and visualization of the SW. Using Pure Data programming, we observe the correct behavior of a probability distribution under the given potential in real time for observers of atto-second scale.
Non symmetric random walk on infinite graph
Marcin J. Zygmunt
2011-01-01
We investigate properties of a non symmetric Markov's chain on an infinite graph. We show the connection with matrix valued random walk polynomials which satisfy the orthogonality formula with respect to non a symmetric matrix valued measure.
Energy Expenditure During Walking with Hand Weights.
Makalous, Susan L.; And Others
1988-01-01
A study of 11 obese adults who exercised with hand weights concludes that using the weights increases the energy demands of walking but only slightly. Research and results are presented and analyzed. (JL)
Weakly directed self-avoiding walks
Bacher, Axel
2010-01-01
We define a new family of self-avoiding walks (SAW) on the square lattice, called weakly directed walks. These walks have a simple characterization in terms of the irreducible bridges that compose them. We determine their generating function. This series has a complex singularity structure and in particular, is not D-finite. The growth constant is approximately 2.54 and is thus larger than that of all natural families of SAW enumerated so far (but smaller than that of general SAW, which is about 2.64). We also prove that the end-to-end distance of weakly directed walks grows linearly. Finally, we study a diagonal variant of this model.
Growing partially directed self-avoiding walks
Privman, V.
1985-01-01
A partially directed self-avoiding walk model with the 'kinetic growth' weighting is solved exactly, on the square lattice and for two restricted, strip geometries. Some finite-size effects are examined.
Non symmetric random walk on infinite graph
Marcin J. Zygmunt
2011-01-01
Full Text Available We investigate properties of a non symmetric Markov's chain on an infinite graph. We show the connection with matrix valued random walk polynomials which satisfy the orthogonality formula with respect to non a symmetric matrix valued measure.
Levy random walks on multiplex networks
Guo, Quantong; Zheng, Zhiming; Moreno, Yamir
2016-01-01
Random walks constitute a fundamental mechanism for many dynamics taking place on complex networks. Besides, as a more realistic description of our society, multiplex networks have been receiving a growing interest, as well as the dynamical processes that occur on top of them. Here, inspired by one specific model of random walks that seems to be ubiquitous across many scientific fields, the Levy flight, we study a new navigation strategy on top of multiplex networks. Capitalizing on spectral graph and stochastic matrix theories, we derive analytical expressions for the mean first passage time and the average time to reach a node on these networks. Moreover, we also explore the efficiency of Levy random walks, which we found to be very different as compared to the single layer scenario, accounting for the structure and dynamics inherent to the multiplex network. Finally, by comparing with some other important random walk processes defined on multiplex networks, we find that in some region of the parameters, a ...
Simple expressions for the long walk distance
Chebotarev, Pavel; Balaji, R
2011-01-01
The walk distances in graphs are defined as the result of appropriate transformations of the $\\sum_{k=0}^\\infty(tA)^k$ proximity measures, where $A$ is the weighted adjacency matrix of a connected weighted graph and $t$ is a sufficiently small positive parameter. The walk distances are graph-geodetic, moreover, they converge to the shortest path distance and to the so-called long walk distance as the parameter $t$ approaches its limiting values. In this paper, simple expressions for the long walk distance are obtained. They involve the generalized inverse, minors, and inverses of submatrices of the symmetric irreducible singular M-matrix ${\\cal L}=\\rho I-A,$ where $\\rho$ is the Perron root of $A.$
Walking (Gait), Balance, and Coordination Problems
... and include: poor balance and slowed walking reduced proprioception (the sensation of where your body parts are ... MS Connection Visit MSConnection.org symptoms of ms proprioception" the 6th sense of ms..please learn!! general ...
Database of Standardized Questionnaires About Walking & Bicycling
This database contains questionnaire items and a list of validation studies for standardized items related to walking and biking. The items come from multiple national and international physical activity questionnaires.
Whittaker, William; Dowling, Kevin
1994-03-01
Carnegie Mellon University's Autonomous Planetary Exploration Program (APEX) is currently building the Daedalus robot; a system capable of performing extended autonomous planetary exploration missions. Extended autonomy is an important capability because the continued exploration of the Moon, Mars and other solid bodies within the solar system will probably be carried out by autonomous robotic systems. There are a number of reasons for this - the most important of which are the high cost of placing a man in space, the high risk associated with human exploration and communication delays that make teleoperation infeasible. The Daedalus robot represents an evolutionary approach to robot mechanism design and software system architecture. Daedalus incorporates key features from a number of predecessor systems. Using previously proven technologies, the Apex project endeavors to encompass all of the capabilities necessary for robust planetary exploration. The Ambler, a six-legged walking machine was developed by CMU for demonstration of technologies required for planetary exploration. In its five years of life, the Ambler project brought major breakthroughs in various areas of robotic technology. Significant progress was made in: mechanism and control, by introducing a novel gait pattern (circulating gait) and use of orthogonal legs; perception, by developing sophisticated algorithms for map building; and planning, by developing and implementing the Task Control Architecture to coordinate tasks and control complex system functions. The APEX project is the successor of the Ambler project.
Intra-limb coordination while walking is affected by cognitive load and walking speed.
Ghanavati, Tabassom; Salavati, Mahyar; Karimi, Noureddin; Negahban, Hossein; Ebrahimi Takamjani, Ismail; Mehravar, Mohammad; Hessam, Masumeh
2014-07-18
Knowledge about intra-limb coordination (ILC) during challenging walking conditions provides insight into the adaptability of central nervous system (CNS) for controlling human gait. We assessed the effects of cognitive load and speed on the pattern and variability of the ILC in young people during walking. Thirty healthy young people (19 female and 11 male) participated in this study. They were asked to perform 9 walking trials on a treadmill, including walking at three paces (preferred, slower and faster) either without a cognitive task (single-task walking) or while subtracting 1׳s or 3׳s from a random three-digit number (simple and complex dual-task walking, respectively). Deviation phase (DP) and mean absolute relative phase (MARP) values-indicators of variability and phase dynamic of ILC, respectively-were calculated using the data collected by a motion capture system. We used a two-way repeated measure analysis of variance for statistical analysis. The results showed that cognitive load had a significant main effect on DP of right shank-foot and thigh-shank, left shank-foot and pelvis-thigh (peffect of walking speed was significant on DP of all segments in each side and MARP of both thigh-shank and pelvis-thigh segments (pcognitive load and walking speed was only significant for MARP values of left shank-foot and right pelvis-thigh (pcognitive load and speed could significantly affect the ILC and variability and phase dynamic during walking. PMID:24861632
Walking as a social practice: dispersed walking and the organisation of everyday practices.
Harries, Tim; Rettie, Ruth
2016-07-01
This paper uses social practice theory to study the interweaving of walking into everyday practices and considers how greater awareness of everyday walking can influence its position within the organisation and scheduling of everyday life. Walking is of policy interest because of its perceived benefits for health. This paper asserts that increased awareness of everyday walking allows users to become more active without having to reschedule existing activities. Using Schatzki's distinction between dispersed and integrative practices, it argues that increasing awareness of dispersed walking can enlist walking into the teleoaffective organisation of some social practices and prompt the performance of new 'health practices' within everyday domains of life such as shopping and employment. While this analysis offers useful insights for the design of behaviour change strategies, it also points to some unintended consequences of using digital feedback to increase walking awareness. In directing the gaze of participants at one particular element of their daily practices, the paper suggests, digital walking feedback provides a 'partial' view of practices: by highlighting the exercise value of walking at the expense of other values it can prompt feedback recipients to pass moral judgements on themselves based on this partial view. A Virtual Abstract of this paper can be found at: https://youtu.be/WV7DUnKD5Mw. PMID:26853086
Does getting a dog increase recreational walking?
Knuiman Matthew W
2008-03-01
Full Text Available Abstract Background This study examines changes in socio-demographic, environmental and intrapersonal factors associated with dog acquisition in non-dog owners at baseline to 12-months follow-up and the effect of dog acquisition on minutes per week of recreational walking. Methods RESIDE study participants completed self-administered questionnaires (baseline and 12-months follow-up measuring physical activity, dog ownership, dog walking behavior as well as environmental, intrapersonal and socio-demographic factors. Analysis was restricted to 'Continuing non-owners' (i.e., non-owners at both baseline and follow-up; n = 681 and 'New dog owners' (i.e., non-owners who acquired a dog by follow-up; n = 92. Results Overall, 12% of baseline non-owners had acquired a dog at follow-up. Dog acquisition was associated with working and having children at home. Those who changed from single to couple marital status were also more likely to acquire a dog. The increase in minutes of walking for recreation within the neighborhood from baseline to follow-up was 48 minutes/week for new dog owners compared with 12 minutes/week for continuing non-owners (p p p > 0.05 after further adjustment for change in baseline to follow-up variables. Increase in intention to walk was the main factor contributing to attenuation of the effect of dog acquisition on recreational walking. Conclusion This study used a large representative sample of non-owners to examine the relationship between dog acquisition and recreational walking and provides evidence to suggest that dog acquisition leads to an increase in walking. The most likely mechanism through which dog acquisition facilitates increased physical activity is through behavioral intention via the dog's positive effect on owner's cognitive beliefs about walking, and through the provision of motivation and social support for walking. The results suggest that behavioral intention mediates the relationship between dog acquisition
Hattori, Kumiko; Ogo, Noriaki; Otsuka, Takafumi
2015-01-01
We show that the `erasing-larger-loops-first' (ELLF) method, which was first introduced for erasing loops from the simple random walk on the Sierpinski gasket, does work also for non-Markov random walks, in particular, self-repelling walks to construct a new family of self-avoiding walks on the Sierpinski gasket. The one-parameter family constructed in this method continuously connects the loop-erased random walk and a self-avoiding walk which has the same asymptotic behavior as the `standard...
Walking Out of the Family Towards Rights
1999-01-01
WALKING in any city or ruralarea in China today, one will seewomen with confidence andpride, with their own work and lives.There is not much difference between theurban and rural women in dress. Theirfaces portray contentment and happiness.These are significant changes which havebeen brought about by women walking outof the family over the past near 50 years,and getting involved in society, alteringtheir dependence on men and making thempeople of dignity. The government knew clearly that to
Tempered stable laws as random walk limits
Chakrabarty, Arijit; Meerschaert, Mark M.
2010-01-01
Stable laws can be tempered by modifying the L\\'evy measure to cool the probability of large jumps. Tempered stable laws retain their signature power law behavior at infinity, and infinite divisibility. This paper develops random walk models that converge to a tempered stable law under a triangular array scheme. Since tempered stable laws and processes are useful in statistical physics, these random walk models can provide a basic physical model for the underlying physical phenomena.
Balancing of the anthropomorphous robot walking
Devaev, V. M.; Nikitina, D. V.; Fadeev, A. Y.
2016-06-01
Anthropomorphic robots are designed a human environment operates: buildings and structures, cabs and etc. The movement of these robots is carried out by walking which provides high throughput to overcome natural and manmade obstacles. The article presents some algorithm results for dynamic walking on the anthropomorphic robot AR601 example. The work is performed according to the Russian Government Program of Competitive Growth of Kazan Federal University.
Propagation in quantum walks and relativistic diffusions
Debbasch, Fabrice; Di Molfetta, Giuseppe; Espaze, David; Foulonneau, Vincent
2013-01-01
Propagation in quantum walks is revisited by showing that very general 1D discrete-time quantum walks with time- and space-dependent coefficients can be described, at the continuous limit, by Dirac fermions coupled to electromagnetic fields. Short-time propagation is also established for relativistic diffusions by presenting new numerical simulations of the Relativistic Ornstein-Uhlenbeck Process. A geometrical generalization of Fick's law is also obtained for this process. The results sugges...
An Efficient Implementation for WalkSAT
Liu, Sixue
2015-01-01
Stochastic local search (SLS) algorithms have exhibited great effectiveness in finding models of random instances of the Boolean satisfiability problem (SAT). As one of the most widely known and used SLS algorithm, WalkSAT plays a key role in the evolutions of SLS for SAT, and also hold state-of-the-art performance on random instances. This work proposes a novel implementation for WalkSAT which decreases the redundant calculations leading to a dramatically speeding up, thus dominates the late...
Danvy, Olivier; Johannsen, Jacob; Zerny, Ian
To celebrate the 20th anniversary of PEPM, we are inviting you to a walk in the semantic park and to inter-derive reduction-based and reduction-free negational normalization functions.......To celebrate the 20th anniversary of PEPM, we are inviting you to a walk in the semantic park and to inter-derive reduction-based and reduction-free negational normalization functions....
More Adults Are Walking PSA (:60)
2012-07-31
This 60 second PSA is based on the August 2012 CDC Vital Signs report. While more adults are walking, only half get the recommended amount of physical activity. Listen to learn how communities, employers, and individuals may help increase walking. Created: 7/31/2012 by Centers for Disease Control and Prevention (CDC). Date Released: 8/7/2012.
Equal Superposition Transformations and Quantum Random Walks
Parashar, Preeti
2007-01-01
The largest ensemble of qubits which satisfy the general transformation of equal superposition is obtained by different methods, namely, linearity, no-superluminal signalling and non-increase of entanglement under LOCC. We also consider the associated quantum random walk and show that all unitary balanced coins give the same asymmetric spatial probability distribution. It is further illustrated that unbalanced coins, upon appropriate superposition, lead to new unbiased walks which have no cla...
The Snail Takes a Walk with Me
王宜鸣; 乐伟国
2008-01-01
@@ 一、故事内容 I'm a snake. Today God gives me a job-I should take a walk with the snail. The snail moves too slowly. I have to scare him. He looks at me, full of shame. I am very angry. I pull him, and even kick.The snail cries, so he stops walking. I feel quite helpless.
Developmental Continuity? Crawling, Cruising, and Walking
Adolph, Karen E.; Berger, Sarah E.; Leo, Andrew J.
2010-01-01
This research examined developmental continuity between “cruising” (moving sideways holding onto furniture for support) and walking. Because cruising and walking involve locomotion in an upright posture, researchers have assumed that cruising is functionally related to walking. Study 1 showed that most infants crawl and cruise concurrently prior to walking, amassing several weeks of experience with both skills. Study 2 showed that cruising infants perceive affordances for locomotion over an adjustable gap in a handrail used for manual support, but despite weeks of cruising experience, cruisers are largely oblivious to the dangers of gaps in the floor beneath their feet. Study 3 replicated the floor-gap findings for infants taking their first independent walking steps, and showed that new walkers also misperceive affordances for locomoting between gaps in a handrail. The findings suggest that weeks of cruising do not teach infants a basic fact about walking: the necessity of a floor to support their body. Moreover, this research demonstrated that developmental milestones that are temporally contiguous and structurally similar might have important functional discontinuities. PMID:21399716
Self-avoiding walks crossing a square
We study a restricted class of self-avoiding walks (SAWs) which start at the origin (0, 0), end at (L, L), and are entirely contained in the square [0, L] x [0, L] on the square lattice Z2. The number of distinct walks is known to grow as λL2+o(L2). We estimate λ = 1.744 550 ± 0.000 005 as well as obtaining strict upper and lower bounds, 1.628 1/3). We also consider the model in which a weight or fugacity x is associated with each step of the walk. This gives rise to a canonical model of a phase transition. For x 1/μ it grows as L2. Here μ is the growth constant of unconstrained SAWs in Z2. For x = 1/μ we provide numerical evidence, but no proof, that the average walk length grows as L4/3. Another problem we study is that of SAWs, as described above, that pass through the central vertex of the square. We estimate the proportion of such walks as a fraction of the total, and find it to be just below 80% of the total number of SAWs. We also consider Hamiltonian walks under the same restriction. They are known to grow as τL2+o(L2) on the same L x L lattice. We give precise estimates for τ as well as upper and lower bounds, and prove that τ < λ
Goals and Social Comparisons Promote Walking Behavior.
Chapman, Gretchen B; Colby, Helen; Convery, Kimberly; Coups, Elliot J
2016-05-01
The effectiveness of a pedometer intervention was affected by manipulating the goals given to participants and by providing social comparison feedback about how participants' performance compared with others. In study 1 (n= 148), university staff members received a low, medium, or high walking goal (10%, 50%, or 100% increase over baseline walking). Participants walked 1358 more steps per day (95% confidence interval [CI], 729, 1985), when receiving a high goal than when receiving a medium goal, but a medium goal did not increase walking relative to a low goal (554 more steps; 95% CI, -71,1179). In study 2 (n= 64), participants received individual feedback only or individual plus social comparison feedback. Participants walked 1120 more steps per day (95% CI, 538, 1703) when receiving social comparison feedback than when receiving only individual feedback. Goals and the performance of others act as reference points and influence the effect that pedometer feedback has on walking behavior, illustrating the applicability of the principles of behavioral economics and social psychology to the design of health behavior interventions. PMID:26139447
Chromosome 19 International Workshop
Pericak-Vance, M.A. (Duke Univ., Durham, NC (United States). Medical Center); Ropers, H.H. (Univ. Hospital Nijmegen, (The Netherlands). Dept. of Human Genetics); Carrano, A.J. (Lawrence Livermore National Lab., CA (United States))
1993-01-04
The Second International Workshop on Human Chromosome 19 was hosted on January 25 and 26, 1992, by the Department of Human Genetics, University Hospital Nijmegen, The Netherlands, at the 'Meerdal Conference Center'. The workshop was supported by a grant from the European Community obtained through HUGO, the Dutch Research Organization (NWO) and the Muscular Dystrophy Association (MDA). Travel support for American participants was provided by the Department of Energy. The goals of this workshop were to produce genetic, physical and integrated maps of chromosome 19, to identify inconsistencies and gaps, and to discuss and exchange resources and techniques available for the completion of these maps. The second day of the meeting was largely devoted to region or disease specific efforts. In particular, the meeting served as a platform for assessing and discussing the recent progress made into the molecular elucidation of myotonic dystrophy.
Quantum walks with tuneable self-avoidance in one dimension
Elizabeth Camilleri; Rohde, Peter P.; Jason Twamley
2014-01-01
Quantum walks exhibit many unique characteristics compared to classical random walks. In the classical setting, self-avoiding random walks have been studied as a variation on the usual classical random walk. Here the walker has memory of its previous locations and preferentially avoids stepping back to locations where it has previously resided. Classical self-avoiding random walks have found numerous algorithmic applications, most notably in the modelling of protein folding. We consider the a...
Tolley, R.; Lumsdon, L.; Bickerstaff, K. [CAST - The Centre for Alternative and Sustainable Transport, Staffordshire University, Stoke on Trent (United Kingdom)
2001-07-01
There is increasing recognition of the importance of walking to the sustainability of cities, set against a continuing decline in everyday walking. This paper reports on a research project, which predicts trends in walking in Europe by 2010 by seeking opinion of experts who are knowledgeable about non-motorised transport. There is a consensus that there will be more walking for leisure and health, but less everyday walking. This will happen despite walking being seen as more important and there being more facilities, infrastructure, information and funding for walking. (author)
Talk the Walk: Does Socio-Cognitive Resource Reallocation Facilitate the Development of Walking?
Geva, Ronny; Orr, Edna
2016-01-01
Walking is of interest to psychology, robotics, zoology, neuroscience and medicine. Human's ability to walk on two feet is considered to be one of the defining characteristics of hominoid evolution. Evolutionary science propses that it emerged in response to limited environmental resources; yet the processes supporting its emergence are not fully understood. Developmental psychology research suggests that walking elicits cognitive advancements. We postulate that the relationship between cognitive development and walking is a bi-directional one; and further suggest that the initiation of novel capacities, such as walking, is related to internal socio-cognitive resource reallocation. We shed light on these notions by exploring infants' cognitive and socio-communicative outputs prospectively from 6-18 months of age. Structured bi/tri weekly evaluations of symbolic and verbal development were employed in an urban cohort (N = 9) for 12 months, during the transition from crawling to walking. Results show links between preemptive cognitive changes in socio-communicative output, symbolic-cognitive tool-use processes, and the age of emergence of walking. Plots of use rates of lower symbolic play levels before and after emergence of new skills illustrate reductions in use of previously attained key behaviors prior to emergence of higher symbolic play, language and walking. Further, individual differences in age of walking initiation were strongly related to the degree of reductions in complexity of object-use (r = .832, p skills that serve recruitment of external resources [socio-communication bids before speech (r = -.696, p computational approach yielded an even stronger link, underscoring internal resource reallocation as a facilitator of walking initiation (r = .901, p<0.001). These preliminary data suggest that representational capacities, symbolic object use, language and social developments, form an integrated adaptable composite, which possibly enables proactive
Quantum walks with tuneable self-avoidance in one dimension
Camilleri, Elizabeth; Rohde, Peter P.; Twamley, Jason
2014-04-01
Quantum walks exhibit many unique characteristics compared to classical random walks. In the classical setting, self-avoiding random walks have been studied as a variation on the usual classical random walk. Here the walker has memory of its previous locations and preferentially avoids stepping back to locations where it has previously resided. Classical self-avoiding random walks have found numerous algorithmic applications, most notably in the modelling of protein folding. We consider the analogous problem in the quantum setting - a quantum walk in one dimension with tunable levels of self-avoidance. We complement a quantum walk with a memory register that records where the walker has previously resided. The walker is then able to avoid returning back to previously visited sites or apply more general memory conditioned operations to control the walk. We characterise this walk by examining the variance of the walker's distribution against time, the standard metric for quantifying how quantum or classical a walk is. We parameterise the strength of the memory recording and the strength of the memory back-action on the walker, and investigate their effect on the dynamics of the walk. We find that by manipulating these parameters, which dictate the degree of self-avoidance, the walk can be made to reproduce ideal quantum or classical random walk statistics, or a plethora of more elaborate diffusive phenomena. In some parameter regimes we observe a close correspondence between classical self-avoiding random walks and the quantum self-avoiding walk.
Michiel P. M. van Nunen, MSc
2013-01-01
Full Text Available It has been suggested that aerobic training should be considered in stroke rehabilitation programs to counteract detrimental health effects and decrease cardiovascular risk caused by inactivity. Robot-assisted treadmill exercise (using a Lokomat device has the potential to increase the duration of walking therapy relative to conventional overground therapy. We investigated whether exercise intensity during Lokomat therapy is adequate to elicit a training effect and how assistance during walking in the Lokomat affects this exercise intensity. Ten patients with stroke (age 54 +/– 9 yr walked in both the Lokomat and in a hallway. Furthermore, 10 nondisabled subjects (age 43 +/– 14 yr walked in the Lokomat at various settings and on a treadmill at various speeds. During walking, oxygen consumption and heart rate were monitored. Results showed that for patients with stroke, exercise intensity did not reach recommended levels (30% heart rate reserve for aerobic training during Lokomat walking. Furthermore, exercise intensity during walking in the Lokomat (9.3 +/– 1.6 mL/min/kg was lower than during overground walking (10.4 +/– 1.3 mL/min/kg. Also, different settings of the Lokomat only had small effects on exercise intensity in nondisabled subjects.
Walking on fractals: diffusion and self-avoiding walks on percolation clusters
We consider random walks (RWs) and self-avoiding walks (SAWs) on disordered lattices directly at the percolation threshold. Applying numerical simulations, we study the scaling behavior of the models on the incipient percolation cluster in space dimensions d = 2, 3, 4. Our analysis yields estimates of universal exponents, governing the scaling laws for configurational properties of RWs and SAWs
Walking on fractals: diffusion and self-avoiding walks on percolation clusters
Blavatska, Viktoria; Janke, Wolfhard
2008-01-01
We consider random walks (RWs) and self-avoiding walks (SAWs) on disordered lattices directly at the percolation threshold. Applying numerical simulations, we study the scaling behavior of the models on the incipient percolation cluster in space dimensions d=2, 3, 4. Our analysis yields estimates of universal exponents, governing the scaling laws for configurational properties of RWs and SAWs.
Walking on fractals: diffusion and self-avoiding walks on percolation clusters
Blavatska, V; Janke, W [Institut fuer Theoretische Physik and Centre for Theoretical Sciences (NTZ), Universitaet Leipzig, Postfach 100 920, D-04009 Leipzig (Germany)], E-mail: Viktoria.Blavatska@itp.uni-leipzig.de, E-mail: viktoria@icmp.lviv.ua, E-mail: Wolfhard.Janke@itp.uni-leipzig.de
2009-01-09
We consider random walks (RWs) and self-avoiding walks (SAWs) on disordered lattices directly at the percolation threshold. Applying numerical simulations, we study the scaling behavior of the models on the incipient percolation cluster in space dimensions d = 2, 3, 4. Our analysis yields estimates of universal exponents, governing the scaling laws for configurational properties of RWs and SAWs.
The associated random walk and martingales in random walks with stationary increments
Grey, D R
2010-01-01
We extend the notion of the associated random walk and the Wald martingale in random walks where the increments are independent and identically distributed to the more general case of stationary ergodic increments. Examples are given where the increments are Markovian or Gaussian, and an application in queueing is considered.
Molecular fundamentals of chromosomal mutagenesis
Precise quantitative correlation between the yield of chromosome structure damages and the yield of DNA damages is shown when comparing data on molecular and cytogenetic investigations carried out in cultural Mammalia cells. As the chromosome structure damage is to be connected with the damage of its carcass structure, then it is natural that DNA damage in loop regions is not to affect considerably the structure, while DNA damage lying on the loop base and connected with the chromosome carcass is to play a determining role in chromosomal mutagenesis. This DNA constitutes 1-2% from the total quantity of nuclear DNA. If one accepts that damages of these regions of DNA are ''hot'' points of chromosomal mutagenesis, then it becomes clear why 1-2% of preparation damages in a cell are realized in chromosome structural damages
Electochemical detection of chromosome translocation
Kwasny, Dorota; Dimaki, Maria; Silahtaroglu, Asli;
2014-01-01
Cytogenetics is a study of the cell structure with a main focus on chromosomes content and their structure. Chromosome abnormalities, such as translocations may cause various genetic disorders and heametological malignancies. Chromosome translocations are structural rearrangements of two...... hybridization approach developed for label-free detection of the chromosome translocations. For specific translocation detection it is necessary to determine that the two DNA sequences forming a derivative chromosome are connected, which is achieved by two subsequent hybridization steps. The electrochemical...... impedance spectroscopy was selected as the sensing method on a microfabricated chip with array of 12 electrode sets. Two independent chips (Chip1 and Chip2) were used for targeting the chromosomal fragments involved in the translocation. Each chip was differentially functionalized with DNA probes matching...
Nilsson, Niels Christian; Serafin, Stefania; Nordahl, Rolf
2014-04-01
Walking-In-Place (WIP) techniques make it possible to facilitate relatively natural locomotion within immersive virtual environments that are larger than the physical interaction space. However, in order to facilitate natural walking experiences one needs to know how to map steps in place to virtual motion. This paper describes two within-subjects studies performed with the intention of establishing the range of perceptually natural walking speeds for WIP locomotion. In both studies, subjects performed a series of virtual walks while exposed to visual gains (optic flow multipliers) ranging from 1.0 to 3.0. Thus, the slowest speed was equal to an estimate of the subjects normal walking speed, while the highest speed was three times greater. The perceived naturalness of the visual speed was assessed using self-reports. The first study compared four different types of movement, namely, no leg movement, walking on a treadmill, and two forms of gestural input for WIP locomotion. The results suggest that WIP locomotion is accompanied by a perceptual distortion of the speed of optic flow. The second study was performed using a 4×2 factorial design and compared four different display field-of-views (FOVs) and two types of movement, walking on a treadmill and WIP locomotion. The results revealed significant main effects of both movement type and field of view, but no significant interaction between the two variables. Particularly, they suggest that the size of the display FOV is inversely proportional to the degree of underestimation of the virtual speeds for both treadmill-mediated virtual walking and WIP locomotion. Combined, the results constitute a first attempt at establishing a set of guidelines specifying what virtual walking speeds WIP gestures should produce in order to facilitate a natural walking experience. PMID:24650984
Intraspecific chromosome variability
N Dubinin
2010-12-01
Full Text Available (Editorial preface. The publication is presented in order to remind us of one of dramatic pages of the history of genetics. It re-opens for the contemporary reader a comprehensive work marking the priority change from plant cytogenetics to animal cytogenetics led by wide population studies which were conducted on Drosophila polytene chromosomes. The year of the publication (1937 became the point of irretrievable branching between the directions of Old World and New World genetics connected with the problems of chromosome variability and its significance for the evolution of the species. The famous book of T. Dobzhansky (1937 was published by Columbia University in the US under the title “Genetics and the origin of species”, and in the shadow of this American ‘skybuilding’ all other works grew dim. It is remarkable that both Dobzhansky and Dubinin come to similar conclusions about the role of chromosomes in speciation. This is not surprising given that they both might be considered as representatives of the Russian genetic school, by their birth and education. Interestingly, Dobzhansky had never referred to the full paper of Dubinin et al. (1937, though a previous short communication in Nature (1936 was included together with all former papers on the related subject. In full, the volume of the original publication printed in the Biological Journal in Moscow comprised 47 pages, in that number 41 pages of the Russian text accompanied by 16 Figs, a table and reference list, and, above all, 6 pages of the English summary. This final part in English is now reproduced in the authors’ version with the only addition being the reference list in the originally printed form.
Reference-assisted chromosome assembly
Kim, Jaebum; Larkin, Denis M; Cai, Qingle; Asan,; Zhang, Yongfen; Ge, Ri-Li; Auvil, Loretta; Capitanu, Boris; Zhang, Guojie; Lewin, Harris A.; Ma, Jian
2013-01-01
One of the most difficult problems in modern genomics is the assembly of full-length chromosomes using next generation sequencing (NGS) data. To address this problem, we developed “reference-assisted chromosome assembly” (RACA), an algorithm to reliably order and orient sequence scaffolds generated by NGS and assemblers into longer chromosomal fragments using comparative genome information and paired-end reads. Evaluation of results using simulated and real genome assemblies indicates that ou...
The discrete-time quaternionic quantum walk on a graph
Konno, Norio; Mitsuhashi, Hideo; Sato, Iwao
2016-02-01
Recently, the quaternionic quantum walk was formulated by the first author as a generalization of discrete-time quantum walks. We deal with the right eigenvalue problem of quaternionic matrices in order to study spectra of the transition matrix of a quaternionic quantum walk. The way to obtain all the right eigenvalues of a quaternionic matrix is given. From the unitary condition on the transition matrix of a quaternionic quantum walk, we deduce some remarkable properties of it. Our main results determine all the right eigenvalues of the quaternionic quantum walk by using those of the corresponding weighted matrix. In addition, we give some examples of quaternionic quantum walks and their right eigenvalues.
Chromosome Connections: Compelling Clues to Common Ancestry
Flammer, Larry
2013-01-01
Students compare banding patterns on hominid chromosomes and see striking evidence of their common ancestry. To test this, human chromosome no. 2 is matched with two shorter chimpanzee chromosomes, leading to the hypothesis that human chromosome 2 resulted from the fusion of the two shorter chromosomes. Students test that hypothesis by looking for…
The variability problem of normal human walking
Simonsen, Erik B; Alkjær, Tine
2012-01-01
Previous investigations have suggested considerable inter-individual variability in the time course pattern of net joint moments during normal human walking, although the limited sample sizes precluded statistical analyses. The purpose of the present study was to obtain joint moment patterns from a...... group of normal subjects and to test whether or not the expected differences would prove to be statistically significant. Fifteen healthy male subjects were recorded on video while they walked across two force platforms. Ten kinematic and kinetic parameters were selected and input to a statistical...... cluster analysis to determine whether or not the 15 subjects could be divided into different 'families' (clusters) of walking strategy. The net joint moments showed a variability corroborating earlier reports. The cluster analysis showed that the 15 subjects could be grouped into two clusters of 5 and 10...
Modeling, simulation and optimization of bipedal walking
Berns, Karsten
2013-01-01
The model-based investigation of motions of anthropomorphic systems is an important interdisciplinary research topic involving specialists from many fields such as Robotics, Biomechanics, Physiology, Orthopedics, Psychology, Neurosciences, Sports, Computer Graphics and Applied Mathematics. This book presents a study of basic locomotion forms such as walking and running is of particular interest due to the high demand on dynamic coordination, actuator efficiency and balance control. Mathematical models and numerical simulation and optimization techniques are explained, in combination with experimental data, which can help to better understand the basic underlying mechanisms of these motions and to improve them. Example topics treated in this book are Modeling techniques for anthropomorphic bipedal walking systems Optimized walking motions for different objective functions Identification of objective functions from measurements Simulation and optimization approaches for humanoid robots Biologically inspired con...
Humanoid robot Lola: design and walking control.
Buschmann, Thomas; Lohmeier, Sebastian; Ulbrich, Heinz
2009-01-01
In this paper we present the humanoid robot LOLA, its mechatronic hardware design, simulation and real-time walking control. The goal of the LOLA-project is to build a machine capable of stable, autonomous, fast and human-like walking. LOLA is characterized by a redundant kinematic configuration with 7-DoF legs, an extremely lightweight design, joint actuators with brushless motors and an electronics architecture using decentralized joint control. Special emphasis was put on an improved mass distribution of the legs to achieve good dynamic performance. Trajectory generation and control aim at faster, more flexible and robust walking. Center of mass trajectories are calculated in real-time from footstep locations using quadratic programming and spline collocation methods. Stabilizing control uses hybrid position/force control in task space with an inner joint position control loop. Inertial stabilization is achieved by modifying the contact force trajectories. PMID:19665558
Getting mobile with a walking-help
Krummheuer, Antonia Lina; Raudaskoski, Pirkko Liisa
in Symbolic Interaction 33: 443-457. Latour, B. (2005).Reassembeling the social. An Introduction to Actor-Network-Theory. Oxford University Press. Ryave, A. L. and J. N. Schenkein. (1974). Not es on the Art of Walking. In Turner, R. (ed.) Ethnomethodology. Selected Readings. Middlesex: Penguin, 265......Ethnomethodology has been one of the few fields were mundane experiences and social ordering such as walking have been a focus of interest (e.g. Ryave and Schenkein 1974). In the present paper we want to discuss how this mundane practice sometimes needs to be achieved through the help of technology...... are understood as a Latourian socio-material networks or assemblages that perform an action, rather than depicting the walking help as an object of human actions (Latour 2005). From that constellation a publicly observable ‘mobile with’ (Goffman 1971) can sometimes emerge (when the support is mostly linguistic...
Fast Scramblers, Democratic Walks and Information Fields
Magan, Javier M
2015-01-01
We study a family of weighted random walks on complete graphs. These `democratic walks' turn out to be explicitly solvable, and we find the hierarchy window for which the characteristic time scale saturates the so-called fast scrambling conjecture. We show that these democratic walks describe well the properties of information spreading in systems in which every degree of freedom interacts with every other degree of freedom, such as Matrix or infinite range models. The argument is based on the analysis of suitably defined `Information fields' ($\\mathcal{I}$), which are shown to evolve stochastically towards stationarity due to unitarity of the microscopic model. The model implies that in democratic systems, stabilization of one subsystem is equivalent to global scrambling. We use these results to study scrambling of infalling perturbations in black hole backgrounds, and argue that the near horizon running coupling constants are connected to entanglement evolution of single particle perturbations in democratic...
Paterson, A D
1998-01-01
Researchers presented results of ongoing research to the X-chromosome workshop of the Fifth World Congress on Psychiatric Genetics, covering a wide range of disorders: X-linked infantile spasms; a complex phenotype associated with deletions of Xp11; male homosexuality; degree of handedness; bipolar affective disorder; schizophrenia; childhood onset psychosis; and autism. This report summarizes the presentations, as well as reviewing previous studies. The focus of this report is on linkage findings for schizophrenia and bipolar disorder from a number of groups. For schizophrenia, low positive lod scores were obtained for markers DXS991 and DXS993 from two studies, although the sharing of alleles was greatest from brother-brother pairs in one study, and sister-sister in the other. Data from the Irish schizophrenia study was also submitted, with no strong evidence for linkage on the X chromosome. For bipolar disease, following the report of a Finnish family linked to Xq24-q27, the Columbia group reported some positive results for this region from 57 families, however, another group found no evidence for linkage to this region. Of interest, is the clustering of low positive linkage results that point to regions for possible further study. PMID:9686435
Chromosome analysis and sorting
Doležel, Jaroslav; Kubaláková, Marie; Suchánková, Pavla; Kovářová, Pavlína; Bartoš, Jan; Šimková, Hana
Weinheim : Wiley-VCH, 2007 - (Doležel, J.; Greilhuber, J.; Suda, J.), s. 373-403 ISBN 978-3-527-31487-4 R&D Projects: GA ČR GA521/04/0607; GA ČR GP521/05/P257; GA ČR GD521/05/H013; GA MŠk(CZ) LC06004 Grant ostatní: Mendelova zemědělská a lesnická univerzita v Brně / Agronomická fakulta(CZ) ME 844 Institutional research plan: CEZ:AV0Z5038910 Source of funding: V - iné verejné zdroje ; V - iné verejné zdroje ; V - iné verejné zdroje ; V - iné verejné zdroje ; V - iné verejné zdroje Keywords : Plant flow cytometry * chromosome sorting * flow cytogenetics Subject RIV: EB - Genetics ; Molecular Biology http://books. google .com/books?id=3cwakORieqUC&pg=PA373&lpg=PA373&dq=Chromosome+analysis+and+sorting&source=web&ots=8IyvJlBQyq&sig=_NlXyQQgBCwpj1pTC9YITvvVZqU
Comprehend DeepWalk as Matrix Factorization
Yang, Cheng; Liu, Zhiyuan
2015-01-01
Word2vec, as an efficient tool for learning vector representation of words has shown its effectiveness in many natural language processing tasks. Mikolov et al. issued Skip-Gram and Negative Sampling model for developing this toolbox. Perozzi et al. introduced the Skip-Gram model into the study of social network for the first time, and designed an algorithm named DeepWalk for learning node embedding on a graph. We prove that the DeepWalk algorithm is actually factoring a matrix M where each e...
Lectures on Self-Avoiding Walks
Bauerschmidt, Roland; Duminil-Copin, Hugo; Goodman, Jesse; Slade, Gordon
2012-01-01
These lecture notes provide a rapid introduction to a number of rigorous results on self-avoiding walks, with emphasis on the critical behaviour. Following an introductory overview of the central problems, an account is given of the Hammersley--Welsh bound on the number of self-avoiding walks and its consequences for the growth rates of bridges and self-avoiding polygons. A detailed proof that the connective constant on the hexagonal lattice equals $\\sqrt{2+\\sqrt{2}}$ is then provided. The la...
Self-Avoiding Walks with Writhe
Moroz, J. David; Kamien, Randall D.
1997-01-01
We map self-avoiding random walks with a chemical potential for writhe to the three-dimensional complex O(N) Chern-Simons theory as N -> 0. We argue that at the Wilson-Fisher fixed point which characterizes normal self-avoiding walks (with radius of gyration exponent nu = 0.588) a small chemical potential for writhe is irrelevant and the Chern-Simons field does not modify the monomer- monomer correlation function. For a large chemical potential the polymer collapses.
Self-avoiding walks with writhe
We map self-avoiding random walks with a chemical potential for writhe to the three-dimensional complex O(N) Chern-Simons theory as N→0. We argue that at the Wilson-Fisher fixed point which characterizes normal self-avoiding walks (with radius of gyration exponent ν∼0.588) a small chemical potential for writhe is irrelevant and the Chern-Simons field does not modify the monomer-monomer correlation function. For a large chemical potential the polymer collapses. (orig.)
Topics in random walks in random environment
Over the last twenty-five years random motions in random media have been intensively investigated and some new general methods and paradigms have by now emerged. Random walks in random environment constitute one of the canonical models of the field. However in dimension bigger than one they are still poorly understood and many of the basic issues remain to this day unresolved. The present series of lectures attempt to give an account of the progresses which have been made over the last few years, especially in the study of multi-dimensional random walks in random environment with ballistic behavior. (author)
Van Cauwenberg Jelle
2012-07-01
Full Text Available Abstract Background Current knowledge on the relationship between the physical environment and walking for transportation among older adults (≥ 65 years is limited. Qualitative research can provide valuable information and inform further research. However, qualitative studies are scarce and fail to include neighborhood outings necessary to study participants’ experiences and perceptions while interacting with and interpreting the local social and physical environment. The current study sought to uncover the perceived environmental influences on Flemish older adults’ walking for transportation. To get detailed and context-sensitive environmental information, it used walk-along interviews. Methods Purposeful convenience sampling was used to recruit 57 older adults residing in urban or semi-urban areas. Walk-along interviews to and from a destination (e.g. a shop located within a 15 minutes’ walk from the participants’ home were conducted. Content analysis was performed using NVivo 9 software (QSR International. An inductive approach was used to derive categories and subcategories from the data. Results Data were categorized in the following categories and subcategories: access to facilities (shops & services, public transit, connectivity, walking facilities (sidewalk quality, crossings, legibility, benches, traffic safety (busy traffic, behavior of other road users, familiarity, safety from crime (physical factors, other persons, social contacts, aesthetics (buildings, natural elements, noise & smell, openness, decay and weather. Conclusions The findings indicate that to promote walking for transportation a neighborhood should provide good access to shops and services, well-maintained walking facilities, aesthetically appealing places, streets with little traffic and places for social interaction. In addition, the neighborhood environment should evoke feelings of familiarity and safety from crime. Future quantitative studies should
Talk the Walk: Does Socio-Cognitive Resource Reallocation Facilitate the Development of Walking?
Orr, Edna
2016-01-01
Walking is of interest to psychology, robotics, zoology, neuroscience and medicine. Human’s ability to walk on two feet is considered to be one of the defining characteristics of hominoid evolution. Evolutionary science propses that it emerged in response to limited environmental resources; yet the processes supporting its emergence are not fully understood. Developmental psychology research suggests that walking elicits cognitive advancements. We postulate that the relationship between cognitive development and walking is a bi-directional one; and further suggest that the initiation of novel capacities, such as walking, is related to internal socio-cognitive resource reallocation. We shed light on these notions by exploring infants’ cognitive and socio-communicative outputs prospectively from 6–18 months of age. Structured bi/tri weekly evaluations of symbolic and verbal development were employed in an urban cohort (N = 9) for 12 months, during the transition from crawling to walking. Results show links between preemptive cognitive changes in socio-communicative output, symbolic-cognitive tool-use processes, and the age of emergence of walking. Plots of use rates of lower symbolic play levels before and after emergence of new skills illustrate reductions in use of previously attained key behaviors prior to emergence of higher symbolic play, language and walking. Further, individual differences in age of walking initiation were strongly related to the degree of reductions in complexity of object-use (r = .832, p < .005), along with increases, counter to the general reduction trend, in skills that serve recruitment of external resources [socio-communication bids before speech (r = -.696, p < .01), and speech bids before walking; r = .729, p < .01)]. Integration of these proactive changes using a computational approach yielded an even stronger link, underscoring internal resource reallocation as a facilitator of walking initiation (r = .901, p<0.001). These
Zoellner Jamie
2012-01-01
Full Text Available Abstract Background Given the documented physical activity disparities that exist among low-income minority communities and the increased focused on socio-ecological approaches to address physical inactivity, efforts aimed at understanding the built environment to support physical activity are needed. This community-based participatory research (CBPR project investigates walking trails perceptions in a high minority southern community and objectively examines walking trails. The primary aim is to explore if perceived and objective audit variables predict meeting recommendations for walking and physical activity, MET/minutes/week of physical activity, and frequency of trail use. Methods A proportional sampling plan was used to survey community residents in this cross-sectional study. Previously validated instruments were pilot tested and appropriately adapted and included the short version of the validated International Physical Activity Questionnaire, trail use, and perceptions of walking trails. Walking trails were assessed using the valid and reliable Path Environmental Audit Tool which assesses four content areas including: design features, amenities, maintenance, and pedestrian safety from traffic. Analyses included Chi-square, one-way ANOVA's, multiple linear regression, and multiple logistic models. Results Numerous (n = 21 high quality walking trails were available. Across trails, there were very few indicators of incivilities and safety features rated relatively high. Among the 372 respondents, trail use significantly predicted meeting recommendations for walking and physical activity, and MET/minutes/week. While controlling for other variables, significant predictors of trail use included proximity to trails, as well as perceptions of walking trail safety, trail amenities, and neighborhood pedestrian safety. Furthermore, while controlling for education, gender, and income; for every one time per week increase in using walking trails
Cohesin in determining chromosome architecture
Haering, Christian H., E-mail: christian.haering@embl.de [Cell Biology and Biophysics Unit, European Molecular Biology Laboratory (EMBL), Heidelberg (Germany); Jessberger, Rolf, E-mail: rolf.jessberger@tu-dresden.de [Institute of Physiological Chemistry, Dresden University of Technology, Dresden (Germany)
2012-07-15
Cells use ring-like structured protein complexes for various tasks in DNA dynamics. The tripartite cohesin ring is particularly suited to determine chromosome architecture, for it is large and dynamic, may acquire different forms, and is involved in several distinct nuclear processes. This review focuses on cohesin's role in structuring chromosomes during mitotic and meiotic cell divisions and during interphase.
Causes of oncogenic chromosomal translocation
Aplan, Peter D.
2005-01-01
Non-random chromosomal translocations are frequently associated with a variety of cancers, especially hematologic malignancies and childhood sarcomas In addition to their diagnostic utility, chromosomal translocations are increasingly being used in the clinic to guide therapeutic decisions. However, the mechanisms which cause these translocations remain poorly understood. Illegit...
Genetics Home Reference: ring chromosome 20 syndrome
... 3 links) Encyclopedia: Chromosome Encyclopedia: Epilepsy Health Topic: Epilepsy Genetic and Rare Diseases Information Center (1 link) Ring chromosome 20 Additional NIH Resources (2 links) National Human Genome Research Institute: Chromosome Abnormalities National Institute of ...
Genetics Home Reference: ring chromosome 14 syndrome
... Encyclopedia: Chromosome Health Topic: Developmental Disabilities Health Topic: Epilepsy Genetic and Rare Diseases Information Center (1 link) Ring chromosome 14 Additional NIH Resources (2 links) National Human Genome Research Institute: Chromosome Abnormalities National Institute of ...
Loop-Erased Walks Intersect Infinitely Often in Four Dimensions
Lawler, Gregory
1998-01-01
In this short note we show that the paths two independent loop-erased random walks in four dimensions intersect infinitely often. We actually prove the stronger result that the cut-points of the two walks intersect infinitely often.
Bacterial chromosome organization and segregation.
Badrinarayanan, Anjana; Le, Tung B K; Laub, Michael T
2015-01-01
If fully stretched out, a typical bacterial chromosome would be nearly 1 mm long, approximately 1,000 times the length of a cell. Not only must cells massively compact their genetic material, but they must also organize their DNA in a manner that is compatible with a range of cellular processes, including DNA replication, DNA repair, homologous recombination, and horizontal gene transfer. Recent work, driven in part by technological advances, has begun to reveal the general principles of chromosome organization in bacteria. Here, drawing on studies of many different organisms, we review the emerging picture of how bacterial chromosomes are structured at multiple length scales, highlighting the functions of various DNA-binding proteins and the impact of physical forces. Additionally, we discuss the spatial dynamics of chromosomes, particularly during their segregation to daughter cells. Although there has been tremendous progress, we also highlight gaps that remain in understanding chromosome organization and segregation. PMID:26566111
Hayes, Hélène
2000-01-01
Chaque chromosome contient une seule molécule d’ADN. L’ADN déroulé d’un noyau de cellule humaine mesurerait environ 1,8 m : chaque molécule d’ADN est enroulée et compactée en plusieurs étapes, grâce à l’association de différentes protéines, et loge dans le noyau de 6 µm de diamètre. Le degré de condensation de l’ADN est variable selon les régions chromosomiques et les régions les moins condensées sont les plus riches en gènes. L’ADN est composé d’une variété de séquences codantes ou non et ré...
X-Chromosome dosage compensation.
Meyer, Barbara J
2005-01-01
In mammals, flies, and worms, sex is determined by distinctive regulatory mechanisms that cause males (XO or XY) and females (XX) to differ in their dose of X chromosomes. In each species, an essential X chromosome-wide process called dosage compensation ensures that somatic cells of either sex express equal levels of X-linked gene products. The strategies used to achieve dosage compensation are diverse, but in all cases, specialized complexes are targeted specifically to the X chromosome(s) of only one sex to regulate transcript levels. In C. elegans, this sex-specific targeting of the dosage compensation complex (DCC) is controlled by the same developmental signal that establishes sex, the ratio of X chromosomes to sets of autosomes (X:A signal). Molecular components of this chromosome counting process have been defined. Following a common step of regulation, sex determination and dosage compensation are controlled by distinct genetic pathways. C. elegans dosage compensation is implemented by a protein complex that binds both X chromosomes of hermaphrodites to reduce transcript levels by one-half. The dosage compensation complex resembles the conserved 13S condensin complex required for both mitotic and meiotic chromosome resolution and condensation, implying the recruitment of ancient proteins to the new task of regulating gene expression. Within each C. elegans somatic cell, one of the DCC components also participates in the separate mitotic/meiotic condensin complex. Other DCC components play pivotal roles in regulating the number and distribution of crossovers during meiosis. The strategy by which C. elegans X chromosomes attract the condensin-like DCC is known. Small, well-dispersed X-recognition elements act as entry sites to recruit the dosage compensation complex and to nucleate spreading of the complex to X regions that lack recruitment sites. In this manner, a repressed chromatin state is spread in cis over short or long distances, thus establishing the
Cardiovascular Responses Associated with Daily Walking in Subacute Stroke
Prajapati, Sanjay K.; Avril Mansfield; Gage, William H; Dina Brooks; McIlroy, William E.
2013-01-01
Despite the importance of regaining independent ambulation after stroke, the amount of daily walking completed during in-patient rehabilitation is low. The purpose of this study is to determine if (1) walking-related heart rate responses reached the minimum intensity necessary for therapeutic aerobic exercise (40%–60% heart rate reserve) or (2) heart rate responses during bouts of walking revealed excessive workload that may limit walking (>80% heart rate reserve). Eight individuals with suba...
Tempo and walking speed with music in the urban context
Marek eFranek; Leon eVan Noorden; Lukas eRezny
2014-01-01
The study explored the effect of music on the temporal aspects of walking behavior in a real outdoor urban setting. First, spontaneous synchronization between the beat of the music and step tempo was explored. The effect of motivational and non-motivational music (Karageorghis et al. 1999) on the walking speed was also studied. Finally, we investigated whether music can mask the effects of visual aspects of the walking route environment, which involve fluctuation of walking speed as a respons...
Tempo and walking speed with music in the urban
Franěk, Marek; Noorden, Leon van, LPAS; Režný, Lukáš
2014-01-01
The study explored the effect of music on the temporal aspects of walking behavior in a real outdoor urban setting. First, spontaneous synchronization between the beat of the music and step tempo was explored. The effect of motivational and non-motivational music (Karageorghis et al., 1999) on the walking speed was also studied. Finally, we investigated whether music can mask the effects of visual aspects of the walking route environment, which involve fluctuation of walking speed as a respon...
Self-Attractive Random Walks: The Case of Critical Drifts
Ioffe, Dmitry; Velenik, Yvan
2012-07-01
Self-attractive random walks (polymers) undergo a phase transition in terms of the applied drift (force): If the drift is strong enough, then the walk is ballistic, whereas in the case of small drifts self-attraction wins and the walk is sub-ballistic. We show that, in any dimension d ≥ 2, this transition is of first order. In fact, we prove that the walk is already ballistic at critical drifts, and establish the corresponding LLN and CLT.
Self-Attractive Random Walks: The Case of Critical Drifts
Ioffe, Dmitry
2011-01-01
Self-attractive random walks undergo a phase transition in terms of the applied drift: If the drift is strong enough, then the walk is ballistic, whereas in the case of small drifts self-attraction wins and the walk is sub-ballistic. We show that, in any dimension at least 2, this transition is of first order. In fact, we prove that the walk is already ballistic at critical drifts, and establish the corresponding LLN and CLT.
DeepWalk: Online Learning of Social Representations
Perozzi, Bryan; Al-Rfou, Rami; Skiena, Steven
2014-01-01
We present DeepWalk, a novel approach for learning latent representations of vertices in a network. These latent representations encode social relations in a continuous vector space, which is easily exploited by statistical models. DeepWalk generalizes recent advancements in language modeling and unsupervised feature learning (or deep learning) from sequences of words to graphs. DeepWalk uses local information obtained from truncated random walks to learn latent representations by treating wa...
Instruction sets for walks and the quantile path transformation
Forman, Noah Mills
2013-01-01
This thesis examines two objects: the stacked-instructions representation of a walk on a general state space, and the novel quantile path transformation for real-valued walks.Instead of representing a walk by a chronological sequence of states visited, we may represent the walk by a collection of lists of instructions located at each state. On successive visits to a state, the walker reads and follows successive instructions from the list. However, there are some collections of finite lists f...
Movement Behavior of High-Heeled Walking
Alkjær, Tine; Raffalt, Peter Christian; Petersen, Nicolas Caesar;
2012-01-01
behavior of high-heeled and barefooted walking in eleven female subjects. The movement variability was quantified by calculation of approximate entropy (ApEn) in the ankle joint angle and the standard deviation (SD) of the stride time intervals. Electromyography (EMG) of the soleus (SO) and tibialis...
Assessment of a Solar System Walk
LoPresto, Michael C.; Murrell, Steven R.; Kirchner, Brian
2010-01-01
The idea of sending students and the general public on a walk through a scale model of the solar system in an attempt to instill an appreciation of the relative scales of the sizes of the objects compared to the immense distances between them is certainly not new. A good number of such models exist, including one on the National Mall in…
Grunbaum, F A
2011-01-01
We exhibit a way to associate a quantum walk (QW) on the non-negative integers to any probability measure on the unit circle. This forces us to consider one step transitions that are not traditionally allowed. We illustrate this in the case of a very interesting measure, originally proposed by F. Riesz for a different purpose.
Myths about the Country Walk Case
Cheit, Ross E.; Mervis, David
2007-01-01
The Country Walk case in Dade County, Florida was long considered a model for how to prosecute a multi-victim child sexual abuse case involving young children. In the past 10 years, however, a contrary view has emerged that the case was tainted by improper interviewing and was likely a false conviction. This is the first scholarly effort to assess…
Localization of M-Particle Quantum Walks
Ampadu, Clement
2011-01-01
We study the motion of M particles performing a quantum walk on the line. Under various conditions on the initial coin states for quantum walkers controlled by the Hadamard operator, we give theoretical criterion to observe the quantum walkers at an initial location with high probability.
A three-dimensional human walking model
Yang, Q. S.; Qin, J. W.; Law, S. S.
2015-11-01
A three-dimensional human bipedal walking model with compliant legs is presented in this paper. The legs are modeled with time-variant dampers, and the model is able to characterize the gait pattern of an individual using a minimal set of parameters. Feedback control, for both the forward and lateral movements, is implemented to regulate the walking performance of the pedestrian. The model provides an improvement over classic invert pendulum models. Numerical studies were undertaken to investigate the effects of leg stiffness and attack angle. Simulation results show that when walking at a given speed, increasing the leg stiffness with a constant attack angle results in a longer step length, a higher step frequency, a faster walking speed and an increase in both the peak vertical and lateral ground reaction forces. Increasing the attack angle with a constant leg stiffness results in a higher step frequency, a decrease in the step length, an increase in the total energy of the system and a decrease in both the peak vertical and lateral ground reaction forces.
Bilocal Dynamics for Self-Avoiding Walks
Caracciolo, Sergio; Ferraro, G; Papinutto, Mauro; Pelissetto, A; Caracciolo, Sergio; Causo, Maria Serena; Ferraro, Giovanni; Papinutto, Mauro; Pelissetto, Andrea
2000-01-01
We introduce several bilocal algorithms for lattice self-avoiding walks that provide reasonable models for the physical kinetics of polymers in the absence of hydrodynamic effects. We discuss their ergodicity in different confined geometries, for instance in strips and in slabs. A short discussion of the dynamical properties in the absence of interactions is given.
Self-avoiding random walk in superspace
The model is presented, where all the critical exponents are calculated exactly. It corresponds to a self-avoiding random walk in superspace of dimension D≤4. For the correlation length the validity of Flory's conjecture (ν=3/(D+2)) is confirmed. (orig.)
Kinetic growth walks on complex networks
Kinetically grown self-avoiding walks on various types of generalized random networks have been studied. Networks with short- and long-tailed degree distributions P(k) were considered (k, degree or connectivity), including scale-free networks with P(k) ∼ k-γ. The long-range behaviour of self-avoiding walks on random networks is found to be determined by finite-size effects. The mean self-intersection length of non-reversal random walks, (l), scales as a power of the system size N: (l) ∼ Nβ, with an exponent β = 0.5 for short-tailed degree distributions and β α, with an exponent α which depends on the lowest degree in the network. Results of approximate probabilistic calculations are supported by those derived from simulations of various kinds of networks. The efficiency of kinetic growth walks to explore networks is largely reduced by inhomogeneity in the degree distribution, as happens for scale-free networks
Bilocal Dynamics for Self-Avoiding Walks
Caracciolo, Sergio; Causo, Maria Serena; Ferraro, Giovanni; Papinutto, Mauro; Pelissetto, Andrea
1999-01-01
We introduce several bilocal algorithms for lattice self-avoiding walks that provide reasonable models for the physical kinetics of polymers in the absence of hydrodynamic effects. We discuss their ergodicity in different confined geometries, for instance in strips and in slabs. A short discussion of the dynamical properties in the absence of interactions is given.
Random walk centrality for temporal networks
Rocha, Luis Enrique Correa
2014-01-01
Nodes can be ranked according to their relative importance within the network. Ranking algorithms based on random walks are particularly useful because they connect topological and diffusive properties of the network. Previous methods based on random walks, as for example the PageRank, have focused on static structures. However, several realistic networks are indeed dynamic, meaning that their structure changes in time. In this paper, we propose a centrality measure for temporal networks based on random walks which we call TempoRank. While in a static network, the stationary density of the random walk is proportional to the degree or the strength of a node, we find that in temporal networks, the stationary density is proportional to the in-strength of the so-called effective network. The stationary density also depends on the sojourn probability q which regulates the tendency of the walker to stay in the node. We apply our method to human interaction networks and show that although it is important for a node ...
Saccadic Body Turns in walking Drosophila
Bart R.H. Geurten
2014-10-01
Full Text Available Drosophila melanogaster structures its optic flow during flight by interspersing translational movements with abrupt body rotations. Whether these ‘body saccades’ are accompanied by steering movements of the head is a matter of debate. By tracking single flies moving freely in an arena, we now discovered that walking Drosophila also perform saccades. Movement analysis revealed that the flies separate rotational from translational movements by quickly turning their bodies by 15 degrees within a tenth of a second. Although walking flies moved their heads by up to 20 degrees about their bodies, their heads moved with the bodies during saccadic turns. This saccadic strategy contrasts with the head saccades reported for e.g. blowflies and honeybees, presumably reflecting optical constraints: modelling revealed that head saccades as described for these latter insects would hardly affect the retinal input in Drosophila because of the lower acuity of its compound eye. The absence of head saccades in Drosophila was associated with the absence of haltere oscillations, which seem to guide head movements in other flies. In addition to adding new twists to Drosophila walking behavior, our analysis shows that Drosophila does not turn its head relative to its body when turning during walking.
Grover search with lackadaisical quantum walks
The lazy random walk, where the walker has some probability of staying put, is a useful tool in classical algorithms. We propose a quantum analogue, the lackadaisical quantum walk, where each vertex is given l self-loops, and we investigate its effects on Grover’s algorithm when formulated as search for a marked vertex on the complete graph of N vertices. For the discrete-time quantum walk using the phase flip coin, adding a self-loop to each vertex boosts the success probability from 1/2 to 1. Additional self-loops, however, decrease the success probability. Using instead the Shenvi, Kempe, and Whaley (2003) coin, adding self-loops simply slows down the search. These coins also differ in that the first is faster than classical when l scales less than N, while the second requires that l scale less than N 2. Finally, continuous-time quantum walks differ from both of these discrete-time examples—the self-loops make no difference at all. These behaviors generalize to multiple marked vertices. (paper)
The Physics of a Walking Robot
Guemez, J.; Fiolhais, M.
2013-01-01
The physics of walking is explored, using a toy as a concrete example and a "toy model" applied to it. Besides using Newton's second law, the problem is also discussed from the thermodynamical perspective. Once the steady state (constant velocity) is achieved, we show that the internal energy of the toy is dissipated as heat in the…
The physics of a walking robot
Güémez, Julio
2014-01-01
The physics of walking is explored, using a toy as a concrete example and a 'toy' model applied to it. Besides the Newton's second law, the problem is also discussed from the thermodynamical perspective. Once the steady state (constant velocity) is achieved, we show that the internal energy of the toy is dissipated as heat in the surroundings.
Go Naked: Diapers Affect Infant Walking
Cole, Whitney G.; Lingeman, Jesse M.; Adolph, Karen E.
2012-01-01
In light of cross-cultural and experimental research highlighting effects of childrearing practices on infant motor skill, we asked whether wearing diapers, a seemingly innocuous childrearing practice, affects infant walking. Diapers introduce bulk between the legs, potentially exacerbating infants' poor balance and wide stance. We show that…
Mesonic spectroscopy of Minimal Walking Technicolor
Del Debbio, Luigi; Lucini, Biagio; Patella, Agostino; Pica, Claudio; Rago, Antonio
2010-01-01
We investigate the structure and the novel emerging features of the mesonic non-singlet spectrum of the Minimal Walking Technicolor (MWT) theory. Precision measurements in the nonsinglet pseudoscalar and vector channels are compared to the expectations for an IR-conformal field theory and a QCD...
Healthy Living Initiative: Running/Walking Club
Stylianou, Michalis; Kulinna, Pamela Hodges; Kloeppel, Tiffany
2014-01-01
This study was grounded in the public health literature and the call for schools to serve as physical activity intervention sites. Its purpose was twofold: (a) to examine the daily distance covered by students in a before-school running/walking club throughout 1 school year and (b) to gain insights on the teachers perspectives of the club.…
Approximation of walking robot stability model
Krejsa, Jiří; Grepl, Robert; Věchet, S.
Praha: Ústav termomechaniky AV ČR, 2004 - (Zolotarev, I.; Poživilova, A.), s. 159-160 ISBN 80-85918-88-9. [Engineering mechanics 2004. Svratka (CZ), 10.05.2004-13.05.2004] Institutional research plan: CEZ:AV0Z2076919 Keywords : approximation * walking robot * stability Subject RIV: JD - Computer Applications, Robot ics
Random walk term weighting for information retrieval
Blanco, R.; Lioma, Christina
2007-01-01
We present a way of estimating term weights for Information Retrieval (IR), using term co-occurrence as a measure of dependency between terms.We use the random walk graph-based ranking algorithm on a graph that encodes terms and co-occurrence dependencies in text, from which we derive term weight...
Underactuated Walking Control via the Kinetic Symmetry
Čelikovský, Sergej
Yakutsk : North-Eastern Federal University named after H.K. Ammosov, Sobolev Institute of Mathematics SB RAS, Lavrentiev Institute of Hydrodinamics SB RAS Novosibirsk State University, 2014. s. 6-7. [International Conference on Mathematical Modeling /7./. 30.06.2014-04.07.2014, Yakutsk] Institutional support: RVO:67985556 Keywords : Kinetic symmetry * virtual constraint * underactuated walking Subject RIV: BC - Control Systems Theory
Sunspot random walk and 22-year variation
Love, Jeffrey J.; Rigler, E. Joshua
2012-01-01
We examine two stochastic models for consistency with observed long-term secular trends in sunspot number and a faint, but semi-persistent, 22-yr signal: (1) a null hypothesis, a simple one-parameter random-walk model of sunspot-number cycle-to-cycle change, and, (2) an alternative hypothesis, a two-parameter random-walk model with an imposed 22-yr alternating amplitude. The observed secular trend in sunspots, seen from solar cycle 5 to 23, would not be an unlikely result of the accumulation of multiple random-walk steps. Statistical tests show that a 22-yr signal can be resolved in historical sunspot data; that is, the probability is low that it would be realized from random data. On the other hand, the 22-yr signal has a small amplitude compared to random variation, and so it has a relatively small effect on sunspot predictions. Many published predictions for cycle 24 sunspots fall within the dispersion of previous cycle-to-cycle sunspot differences. The probability is low that the Sun will, with the accumulation of random steps over the next few cycles, walk down to a Dalton-like minimum. Our models support published interpretations of sunspot secular variation and 22-yr variation resulting from cycle-to-cycle accumulation of dynamo-generated magnetic energy.
Adaptive Nonlinear Tracking for Robotic Walking
Dolinský, Kamil; Čelikovský, Sergej
2012-01-01
Roč. 1, č. 1 (2012), s. 28-35. ISSN 2223-7038 Institutional research plan: CEZ:AV0Z10750506 Keywords : Adaptive control * Kalman filter * walking robot s Subject RIV: BC - Control Systems Theory http://lib.physcon.ru/doc?id=9e51935aa5bc
LMI based design for the Acrobot walking
Anderle, Milan; Čelikovský, Sergej; Henrion, D.; Zikmund, Jiří
Gifu: IFAC, 2009, s. 595-600. [SYROCO'09. Gifu (JP), 09.09.2009-12.09.2009] R&D Projects: GA ČR(CZ) GA102/08/0186; GA MŠk LA09026 Institutional research plan: CEZ:AV0Z10750506 Keywords : Linear matrix inequalities (LMI) * underactuated mechanical systems * walking robot s Subject RIV: BC - Control Systems Theory